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Optimal Conditions For Aav Vector Production In He

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Paper Recombinant AAV Vectors for Enhanced Expression of Authentic IgG.

Fuchs, Sebastian P, Martinez-Navio, José M, Gao, Guangping, Desrosiers, Ronald C · 2016 · PloS one · DOI

Full title: Recombinant AAV Vectors for Enhanced Expression of Authentic IgG.

Authors: Fuchs, Sebastian P, Martinez-Navio, José M, Gao, Guangping, Desrosiers, Ronald C

Year: 2016

Venue: PloS one

DOI: https://doi.org/10.1371/journal.pone.0158009

Paper Platforms, advances, and technical challenges in virus-like particles-based vaccines

Gupta, Reeshu, Arora, Kajal, Roy, Sourav Singha, Joseph, Abyson, Rastogi, Ruchir, Arora, Nupur Mehrotra, Kundu, Prabuddha K. · 2023 · Frontiers in Immunology · DOI

Full title: Platforms, advances, and technical challenges in virus-like particles-based vaccines

Authors: Gupta, Reeshu, Arora, Kajal, Roy, Sourav Singha, Joseph, Abyson, Rastogi, Ruchir, Arora, Nupur Mehrotra, Kundu, Prabuddha K.

Year: 2023

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2023.1123805

Paper Construction of PR39 recombinant AAV under control of the HRE promoter and the effect of recombinant AAV on gene therapy of ischemic heart disease.

Sun, Lijun, Hao, Yuewen, Nie, Xiaowei, Zhang, Xuexin, Yang, Guangxiao, Wang, Quanying · 2012 · Experimental and therapeutic medicine · DOI

Full title: Construction of PR39 recombinant AAV under control of the HRE promoter and the effect of recombinant AAV on gene therapy of ischemic heart disease.

Authors: Sun, Lijun, Hao, Yuewen, Nie, Xiaowei, Zhang, Xuexin, Yang, Guangxiao, Wang, Quanying

Year: 2012

Venue: Experimental and therapeutic medicine

DOI: https://doi.org/10.3892/etm.2012.674

Paper Transgene Expression in Cultured Cells Using Unpurified Recombinant Adeno-Associated Viral Vectors

Benyamini, Brian, Esbin, Meagan N., Whitney, Oscar N., Walther, Nike, Maurer, Anna C. · 2023 · DOI

Full title: Transgene Expression in Cultured Cells Using Unpurified Recombinant Adeno-Associated Viral Vectors

Authors: Benyamini, Brian, Esbin, Meagan N., Whitney, Oscar N., Walther, Nike, Maurer, Anna C.

Year: 2023

DOI: https://doi.org/10.1101/2023.03.20.533580

Paper Development of AAV-mediated gene therapy for autosomal recessive bestrophinopathy

Wood, Shaun · 2017 · DOI

Full title: Development of AAV-mediated gene therapy for autosomal recessive bestrophinopathy

Authors: Wood, Shaun

Year: 2017

DOI: https://doi.org/10.5287/ora-1475jodo5

Paper Engineered CHO cells as a novel AAV production platform for gene therapy delivery

Nagy, Abdou, Chakrabarti, Lina, Kurasawa, James, Mulagapati, Sri Hari Raju, Devine, Paul N., Therres, Jamy, Chen, Yuyan, Schmelzer, Albert E. · 2023 · Scientific Reports · DOI

Full title: Engineered CHO cells as a novel AAV production platform for gene therapy delivery

Authors: Nagy, Abdou, Chakrabarti, Lina, Kurasawa, James, Mulagapati, Sri Hari Raju, Devine, Paul N., Therres, Jamy, Chen, Yuyan, Schmelzer, Albert E.

Year: 2023

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-023-46298-3

Paper CRISPR/Cas9 as an antiviral against Orthopoxviruses using an AAV vector.

Siegrist, Cathryn M, Kinahan, Sean M, Settecerri, Taylor, Greene, Adrienne C, Santarpia, Joshua L · 2020 · Scientific reports · DOI

Full title: CRISPR/Cas9 as an antiviral against Orthopoxviruses using an AAV vector.

Authors: Siegrist, Cathryn M, Kinahan, Sean M, Settecerri, Taylor, Greene, Adrienne C, Santarpia, Joshua L

Year: 2020

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-020-76449-9

Paper High-purity AAV vector production utilizing recombination-dependent minicircle formation and genetic coupling.

Liu, Hao, Liu, Nan, Zhou, Chen, Du, Ailing, Kapadia, Mayank, Tai, Phillip W L, Barton, Erik, Gao, Guangping, Wang, Dan · 2025 · EMBO molecular medicine · DOI

Full title: High-purity AAV vector production utilizing recombination-dependent minicircle formation and genetic coupling.

Authors: Liu, Hao, Liu, Nan, Zhou, Chen, Du, Ailing, Kapadia, Mayank, Tai, Phillip W L, Barton, Erik, Gao, Guangping, Wang, Dan

Year: 2025

Venue: EMBO molecular medicine

DOI: https://doi.org/10.1038/s44321-025-00248-w

Paper Nano-vesicles for gene delivery

Tan, Karen Li Ping · 2006 · DOI

Full title: Nano-vesicles for gene delivery

Authors: Tan, Karen Li Ping

Year: 2006

DOI: https://doi.org/10.32657/10356/2194

Paper An Overview of Methods and Tools for Transfection of Eukaryotic Cells in vitro

Fus-Kujawa, Agnieszka, Pruś, Paweł, Bajdak-Rusinek, Karolina, Teper, Paulina, Gawron, Katarzyna, Kowalczuk, Agnieszka, Sieroń, Aleksander L. · 2021 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: An Overview of Methods and Tools for Transfection of Eukaryotic Cells in vitro

Authors: Fus-Kujawa, Agnieszka, Pruś, Paweł, Bajdak-Rusinek, Karolina, Teper, Paulina, Gawron, Katarzyna, Kowalczuk, Agnieszka, Sieroń, Aleksander L.

Year: 2021

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2021.701031

Paper Targeted knockdown of ATM, ATR, and PDEδ increases Gag HIV-1 VLP production in HEK293 cells

Díaz‐Maneh, Andy, Pérez‐Rubio, Pol, Granés, Cristina Rigau, Bosch-Molist, Laia, Lavado‐García, Jesús, Gòdia, Francesc, Cervera, Laura · 2025 · Applied Microbiology and Biotechnology · DOI

Full title: Targeted knockdown of ATM, ATR, and PDEδ increases Gag HIV-1 VLP production in HEK293 cells

Authors: Díaz‐Maneh, Andy, Pérez‐Rubio, Pol, Granés, Cristina Rigau, Bosch-Molist, Laia, Lavado‐García, Jesús, Gòdia, Francesc, Cervera, Laura

Year: 2025

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-024-13389-8

Paper Targeted UDP-glucose ceramide glucosyltransferase stable overexpression induces a metabolic switch improving cell performance at high cell density.

Rahimi, Marzia, Nielsen, Lars K, Lavado-García, Jesús · 2025 · Frontiers in bioengineering and biotechnology · DOI

Full title: Targeted UDP-glucose ceramide glucosyltransferase stable overexpression induces a metabolic switch improving cell performance at high cell density.

Authors: Rahimi, Marzia, Nielsen, Lars K, Lavado-García, Jesús

Year: 2025

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2025.1690203

Paper AAV process intensification by perfusion bioreaction and integrated clarification

Mendes, João P., Fernandes, Bárbara, Pineda, Earl, Kudugunti, Shashi, Bransby, Mike, Gantier, René, Peixoto, Cristina, Alves, Paula M., Roldão, António, Silva, Ricardo J. S. · 2022 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: AAV process intensification by perfusion bioreaction and integrated clarification

Authors: Mendes, João P., Fernandes, Bárbara, Pineda, Earl, Kudugunti, Shashi, Bransby, Mike, Gantier, René, Peixoto, Cristina, Alves, Paula M., Roldão, António, Silva, Ricardo J. S.

Year: 2022

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2022.1020174

Paper AAV Gene Therapy for MPS1-associated Corneal Blindness.

Vance, Melisa, Llanga, Telmo, Bennett, Will, Woodard, Kenton, Murlidharan, Giridhar, Chungfat, Neil, Asokan, Aravind, Gilger, Brian, Kurtzberg, Joanne, Samulski, R Jude, Hirsch, Matthew L · 2016 · Scientific reports · DOI

Full title: AAV Gene Therapy for MPS1-associated Corneal Blindness.

Authors: Vance, Melisa, Llanga, Telmo, Bennett, Will, Woodard, Kenton, Murlidharan, Giridhar, Chungfat, Neil, Asokan, Aravind, Gilger, Brian, Kurtzberg, Joanne, Samulski, R Jude, Hirsch, Matthew L

Year: 2016

Venue: Scientific reports

DOI: https://doi.org/10.1038/srep22131

Paper Optimization of lentiviral vector production for scale-up in fixed-bed bioreactor

Valkama, Anniina J., Leinonen, Hanna, Lipponen, Eevi M., Turkki, Vesa, Malinen, Jukka, Heikura, Tommi, Ylä‐Herttuala, Seppo, Lesch, Hanna P. · 2017 · Gene Therapy · DOI

Full title: Optimization of lentiviral vector production for scale-up in fixed-bed bioreactor

Authors: Valkama, Anniina J., Leinonen, Hanna, Lipponen, Eevi M., Turkki, Vesa, Malinen, Jukka, Heikura, Tommi, Ylä‐Herttuala, Seppo, Lesch, Hanna P.

Year: 2017

Venue: Gene Therapy

DOI: https://doi.org/10.1038/gt.2017.91

Paper Comparative transcriptomic and proteomic kinetic analysis of adeno-associated virus production systems.

Lin, Yu-Chieh, Lu, Min, Cai, Wen, Hu, Wei-Shou · 2024 · Applied microbiology and biotechnology · DOI

Full title: Comparative transcriptomic and proteomic kinetic analysis of adeno-associated virus production systems.

Authors: Lin, Yu-Chieh, Lu, Min, Cai, Wen, Hu, Wei-Shou

Year: 2024

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-024-13203-5

Paper Proton-transfer-reaction mass spectrometry (PTR-MS) for online monitoring of glucose depletion and cell concentrations in HEK 293 gene therapy processes.

Bayer, Benjamin, Maccani, Andreas, Jahn, Johanna, Duerkop, Mark, Kapeller, Ewald, Pletzenauer, Robert, Kraus, Barbara, Striedner, Gerald, Hernandez Bort, Juan A · 2022 · Biotechnology letters · DOI

Full title: Proton-transfer-reaction mass spectrometry (PTR-MS) for online monitoring of glucose depletion and cell concentrations in HEK 293 gene therapy processes.

Authors: Bayer, Benjamin, Maccani, Andreas, Jahn, Johanna, Duerkop, Mark, Kapeller, Ewald, Pletzenauer, Robert, Kraus, Barbara, Striedner, Gerald, Hernandez Bort, Juan A

Year: 2022

Venue: Biotechnology letters

DOI: https://doi.org/10.1007/s10529-021-03205-y

Paper Fast, efficient and virus-free generation of TRAC -replaced CAR T cells

Kath, Jonas, Du, Weijie, Thommandru, Bernice, Turk, Rolf, Amini, Leila, Stein, Maik, Zittel, Tatiana, Martini, Stefania, Ostendorf, Lennard, Wilhelm, Andreas, Akyüz, Levent, Rehm, Armin, Höpken, Uta E., Prüß, Axel, Künkele, Annette, Jacobi, Ashley M., Volk, Hans‐Dieter, Schmueck‐Henneresse, Michael, Reinke, Petra, Wagner, Dimitrios L. · 2021 · DOI

Full title: Fast, efficient and virus-free generation of TRAC -replaced CAR T cells

Authors: Kath, Jonas, Du, Weijie, Thommandru, Bernice, Turk, Rolf, Amini, Leila, Stein, Maik, Zittel, Tatiana, Martini, Stefania, Ostendorf, Lennard, Wilhelm, Andreas, Akyüz, Levent, Rehm, Armin, Höpken, Uta E., Prüß, Axel, Künkele, Annette, Jacobi, Ashley M., Volk, Hans‐Dieter, Schmueck‐Henneresse, Michael, Reinke, Petra, Wagner, Dimitrios L.

Year: 2021

DOI: https://doi.org/10.1101/2021.02.14.431017

Paper With small viruses come giant responsibilities - Next-generation parvoviral vectors for human gene therapy with extended packaging capacity and enhanced safety profile

Fakhiri, Julia · 2019 · heiDOK (Heidelberg University) · DOI

Full title: With small viruses come giant responsibilities - Next-generation parvoviral vectors for human gene therapy with extended packaging capacity and enhanced safety profile

Authors: Fakhiri, Julia

Year: 2019

Venue: heiDOK (Heidelberg University)

DOI: https://doi.org/10.11588/heidok.00027326

Paper Potent immunogenicity and neutralization of recombinant adeno-associated virus expressing the glycoprotein of severe fever with thrombocytopenia virus.

Shimoyama, Toshiaki, Oba, Mami, Takemae, Hitoshi, Omatsu, Tsutomu, Tani, Hideki, Mizutani, Tetsuya · 2024 · The Journal of veterinary medical science · DOI

Full title: Potent immunogenicity and neutralization of recombinant adeno-associated virus expressing the glycoprotein of severe fever with thrombocytopenia virus.

Authors: Shimoyama, Toshiaki, Oba, Mami, Takemae, Hitoshi, Omatsu, Tsutomu, Tani, Hideki, Mizutani, Tetsuya

Year: 2024

Venue: The Journal of veterinary medical science

DOI: https://doi.org/10.1292/jvms.23-0375

Paper Adeno-Associated Viruses Serotype 2-Mediated RNA Interference Efficiently Inhibits Rabies Virus Replication In Vitro and In Vivo

Wu, Hongxia, Wang, Hualei, Guo, Xiaofeng, Yang, Yujiao, Ma, Jinzhu, Wang, Tiecheng, Gao, Yuwei, Zhao, Yongkun, Yang, Songtao, Xia, Xianzhu · 2013 · Journal of Veterinary Medical Science · DOI

Full title: Adeno-Associated Viruses Serotype 2-Mediated RNA Interference Efficiently Inhibits Rabies Virus Replication In Vitro and In Vivo

Authors: Wu, Hongxia, Wang, Hualei, Guo, Xiaofeng, Yang, Yujiao, Ma, Jinzhu, Wang, Tiecheng, Gao, Yuwei, Zhao, Yongkun, Yang, Songtao, Xia, Xianzhu

Year: 2013

Venue: Journal of Veterinary Medical Science

DOI: https://doi.org/10.1292/jvms.13-0127

Paper Development of a CENH3-based and non-viral vector system

Fueloep, Stefanie · 2014 · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · DOI

Full title: Development of a CENH3-based and non-viral vector system

Authors: Fueloep, Stefanie

Year: 2014

Venue: Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München)

DOI: https://doi.org/10.5282/edoc.16537

Paper The membrane associated accessory protein is an adeno-associated viral egress factor

Elmore, Zachary C., Havlik, L. Patrick, Oh, Daniel K., Anderson, Leif, Daaboul, George G., Devlin, Garth, Vincent, Heather A., Asokan, Aravind · 2021 · Nature Communications · DOI

Full title: The membrane associated accessory protein is an adeno-associated viral egress factor

Authors: Elmore, Zachary C., Havlik, L. Patrick, Oh, Daniel K., Anderson, Leif, Daaboul, George G., Devlin, Garth, Vincent, Heather A., Asokan, Aravind

Year: 2021

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-021-26485-4

Paper Improving HEK293-based AAV-production using GSMMs, and a multi-omics approach

L. Zehetner, D. Széliová, B. Kraus, J. A. H. Bort, J. Zanghellini, Team, Manfred Ostermann, Katharina Portner, Ronald Leitner, Sonja Muellner, Robert Pachlinger, Susanne Heider, Carolin-Isabel Kahlig, Lucia Micutkova, Peter Andorfer, Bernd Eisenhut, Felix Innthaler, Fuchsberger, Fabian Knofl, Andrea Seybel, Sabine Unterthurner · 2024 · bioRxiv · DOI

Full title: Improving HEK293-based AAV-production using GSMMs, and a multi-omics approach

Authors: L. Zehetner, D. Széliová, B. Kraus, J. A. H. Bort, J. Zanghellini, Team, Manfred Ostermann, Katharina Portner, Ronald Leitner, Sonja Muellner, Robert Pachlinger, Susanne Heider, Carolin-Isabel Kahlig, Lucia Micutkova, Peter Andorfer, Bernd Eisenhut, Felix Innthaler, Fuchsberger, Fabian Knofl, Andrea Seybel, Sabine Unterthurner

Year: 2024

Venue: bioRxiv

DOI: https://doi.org/10.1101/2024.10.10.617556

Paper Production of adeno-associated virus vectors for in vitro and in vivo applications

Kimura, Toyokazu, Ferrán, Beatriz, Tsukahara, Yuko, Shang, Qifan, Desai, Suveer, Fedoce, Alessandra, Pimentel, David R., Luptak, Ivan, Adachi, Takeshi, Ido, Yasuo, Matsui, Reiko, Bachschmid, Markus · 2019 · Scientific Reports · DOI

Full title: Production of adeno-associated virus vectors for in vitro and in vivo applications

Authors: Kimura, Toyokazu, Ferrán, Beatriz, Tsukahara, Yuko, Shang, Qifan, Desai, Suveer, Fedoce, Alessandra, Pimentel, David R., Luptak, Ivan, Adachi, Takeshi, Ido, Yasuo, Matsui, Reiko, Bachschmid, Markus

Year: 2019

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-019-49624-w

Paper A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis

Prakash, Satya, Shao, M., Paul, Arghya, Abbasi, Sana, Chahal, Parminder S., Mena, Jimmy A., Montes, Johnny, Kamen, Amine · 2012 · International Journal of Nanomedicine · DOI

Full title: A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis

Authors: Prakash, Satya, Shao, M., Paul, Arghya, Abbasi, Sana, Chahal, Parminder S., Mena, Jimmy A., Montes, Johnny, Kamen, Amine

Year: 2012

Venue: International Journal of Nanomedicine

DOI: https://doi.org/10.2147/ijn.s26891

Paper Bioprocess Development and Bioreactor Scale-Up for the Production of Recombinant Lentiviral Viral Vectors in HEK293 Suspension Cell Culture

Robitaille, Julien, Manceur, Aziza, Rodenbrock, Anja, Loignon, Martin · 2024 · Biochemistry · DOI

Full title: Bioprocess Development and Bioreactor Scale-Up for the Production of Recombinant Lentiviral Viral Vectors in HEK293 Suspension Cell Culture

Authors: Robitaille, Julien, Manceur, Aziza, Rodenbrock, Anja, Loignon, Martin

Year: 2024

Venue: Biochemistry

DOI: https://doi.org/10.5772/intechopen.114000

Paper Synergistic Effect of Cationic Lipids with Different Polarheads, Central Core Structures and Hydrophobic Tails on Gene Transfection Efficiency

Niyomtham, Nattisa, Apiratikul, Nuttapon, Chanchang, Kanyarat, Opanasopit, Praneet, Yingyongnarongkul, Boon‐ek · 2014 · Biological and Pharmaceutical Bulletin · DOI

Full title: Synergistic Effect of Cationic Lipids with Different Polarheads, Central Core Structures and Hydrophobic Tails on Gene Transfection Efficiency

Authors: Niyomtham, Nattisa, Apiratikul, Nuttapon, Chanchang, Kanyarat, Opanasopit, Praneet, Yingyongnarongkul, Boon‐ek

Year: 2014

Venue: Biological and Pharmaceutical Bulletin

DOI: https://doi.org/10.1248/bpb.b14-00349

Paper Factors affecting rAAV titers during triple-plasmid transient transfection in HEK-293 cells.

Pistek, Martina, Andorfer, Peter, Grabherr, Reingard, Kraus, Barbara, Hernandez Bort, Juan A · 2024 · Biotechnology letters · DOI

Full title: Factors affecting rAAV titers during triple-plasmid transient transfection in HEK-293 cells.

Authors: Pistek, Martina, Andorfer, Peter, Grabherr, Reingard, Kraus, Barbara, Hernandez Bort, Juan A

Year: 2024

Venue: Biotechnology letters

DOI: https://doi.org/10.1007/s10529-024-03520-0

Paper Analysis of the impact of pluronic acid on the thermal stability and infectivity of AAV6.2FF.

Thomas, Sylvia P, Spinelli, Marcus M, Rghei, Amira D, Lopes, Jordyn A, Zielinska, Nicole, McLeod, Benjamin M, Pei, Yanlong, Zhang, Wei, Thebaud, Bernard, Karimi, Khalil, Wootton, Sarah K · 2024 · BMC biotechnology · DOI

Full title: Analysis of the impact of pluronic acid on the thermal stability and infectivity of AAV6.2FF.

Authors: Thomas, Sylvia P, Spinelli, Marcus M, Rghei, Amira D, Lopes, Jordyn A, Zielinska, Nicole, McLeod, Benjamin M, Pei, Yanlong, Zhang, Wei, Thebaud, Bernard, Karimi, Khalil, Wootton, Sarah K

Year: 2024

Venue: BMC biotechnology

DOI: https://doi.org/10.1186/s12896-024-00853-6

Paper Viral vector production in the integrity® iCELLis® single-use fixed-bed bioreactor, from bench-scale to industrial scale

Lennaertz, Alexandre, Knowles, Shane, Drugmand, Jean‐Christophe, Castillo, José · 2013 · BMC Proceedings · DOI

Full title: Viral vector production in the integrity® iCELLis® single-use fixed-bed bioreactor, from bench-scale to industrial scale

Authors: Lennaertz, Alexandre, Knowles, Shane, Drugmand, Jean‐Christophe, Castillo, José

Year: 2013

Venue: BMC Proceedings

DOI: https://doi.org/10.1186/1753-6561-7-s6-p59

Paper A comparison of synthetic oligodeoxynucleotides, DNA fragments and AAV-1 for targeted episomal and chromosomal gene repair

Leclerc, X., Danos, Olivier, Scherman, Daniel, Kichler, Antoine · 2009 · BMC Biotechnology · DOI

Full title: A comparison of synthetic oligodeoxynucleotides, DNA fragments and AAV-1 for targeted episomal and chromosomal gene repair

Authors: Leclerc, X., Danos, Olivier, Scherman, Daniel, Kichler, Antoine

Year: 2009

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-9-35

Paper Profiling the impact of the promoters on CRISPR-Cas12a system in human cells

Li, Jinhe, Liang, Qinchun, Zhou, Huaping, Zhou, Ming, Huang, Hongxin · 2023 · Cellular & Molecular Biology Letters · DOI

Full title: Profiling the impact of the promoters on CRISPR-Cas12a system in human cells

Authors: Li, Jinhe, Liang, Qinchun, Zhou, Huaping, Zhou, Ming, Huang, Hongxin

Year: 2023

Venue: Cellular & Molecular Biology Letters

DOI: https://doi.org/10.1186/s11658-023-00454-9

Paper Analytical characterization of full, intermediate, and empty AAV capsids.

McColl-Carboni, Aisleen, Dollive, Serena, Laughlin, Sarah, Lushi, Rudenc, MacArthur, Michael, Zhou, Shanshan, Gagnon, Jeffrey, Smith, Christopher A, Burnham, Brenda, Horton, Robert, Lata, Dimpal, Uga, Brianna, Natu, Kalyani, Michel, Emmanuela, Slater, Celia, DaSilva, Evan, Bruccoleri, Robert, Kelly, Tim, McGivney, James B · 2024 · Gene therapy · DOI

Full title: Analytical characterization of full, intermediate, and empty AAV capsids.

Authors: McColl-Carboni, Aisleen, Dollive, Serena, Laughlin, Sarah, Lushi, Rudenc, MacArthur, Michael, Zhou, Shanshan, Gagnon, Jeffrey, Smith, Christopher A, Burnham, Brenda, Horton, Robert, Lata, Dimpal, Uga, Brianna, Natu, Kalyani, Michel, Emmanuela, Slater, Celia, DaSilva, Evan, Bruccoleri, Robert, Kelly, Tim, McGivney, James B

Year: 2024

Venue: Gene therapy

DOI: https://doi.org/10.1038/s41434-024-00444-2

Paper Self-attenuating adenovirus enables production of recombinant adeno-associated virus for high manufacturing yield without contamination

Su, Weiheng, Patrício, Maria I., Duffy, Margaret R., Krakowiak, Jakub M., Seymour, Leonard W., Cawood, Ryan · 2022 · Nature Communications · DOI

Full title: Self-attenuating adenovirus enables production of recombinant adeno-associated virus for high manufacturing yield without contamination

Authors: Su, Weiheng, Patrício, Maria I., Duffy, Margaret R., Krakowiak, Jakub M., Seymour, Leonard W., Cawood, Ryan

Year: 2022

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-022-28738-2

Paper Non-viral Gene Delivery Methods for Bone and Joints

Gantenbein, Benjamin, Tang, Shirley, Guerrero, Julien, Higuita‐Castro, Natalia, Salazar‐Puerta, Ana I., Croft, Andreas S., Gazdhar, Amiq, Purmessur, Devina · 2020 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Non-viral Gene Delivery Methods for Bone and Joints

Authors: Gantenbein, Benjamin, Tang, Shirley, Guerrero, Julien, Higuita‐Castro, Natalia, Salazar‐Puerta, Ana I., Croft, Andreas S., Gazdhar, Amiq, Purmessur, Devina

Year: 2020

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2020.598466

Paper Eukaryotic-driven directed evolution of Cas9 nucleases

Ruta, Giulia Vittoria, Ciciani, Matteo, Kheir, Eyemen, Gentile, Michele Domenico, Amistadi, Simone, Casini, Antonio, Cereseto, Anna · 2024 · Genome biology · DOI

Full title: Eukaryotic-driven directed evolution of Cas9 nucleases

Authors: Ruta, Giulia Vittoria, Ciciani, Matteo, Kheir, Eyemen, Gentile, Michele Domenico, Amistadi, Simone, Casini, Antonio, Cereseto, Anna

Year: 2024

Venue: Genome biology

DOI: https://doi.org/10.1186/s13059-024-03215-9

Paper Enhancer viruses and a transgenic platform for combinatorial cell subclass-specific labeling

Graybuck, Lucas T., Daigle, Tanya L., Sedeño-Cortés, Adriana E., Walker, Miranda, Kalmbach, Brian, Lenz, Garreck, Nguyen, Thuc Nghi, Garren, Emma, Kim, Tae Kyung, Siverts, La’Akea, Bendrick, Jacqueline L., Zhou, Thomas, Mortrud, Marty, Yao, Shenqin, Çetin, Ali, Larsen, Rachael, Esposito, Luke, Gore, Bryan B., Szelenyi, Eric R, Morin, Elyse L., Mich, John K., Dee, Nick, Goldy, Jeff, Smith, Kimberly A., Yao, Zizhen, Gradinaru, Viviana, Sunkin, Susan M., Lein, Ed S., Levi, Boaz P., Ting, Jonathan T., Zeng, Hongkui, Tasic, Bosiljka · 2019 · DOI

Full title: Enhancer viruses and a transgenic platform for combinatorial cell subclass-specific labeling

Authors: Graybuck, Lucas T., Daigle, Tanya L., Sedeño-Cortés, Adriana E., Walker, Miranda, Kalmbach, Brian, Lenz, Garreck, Nguyen, Thuc Nghi, Garren, Emma, Kim, Tae Kyung, Siverts, La’Akea, Bendrick, Jacqueline L., Zhou, Thomas, Mortrud, Marty, Yao, Shenqin, Çetin, Ali, Larsen, Rachael, Esposito, Luke, Gore, Bryan B., Szelenyi, Eric R, Morin, Elyse L., Mich, John K., Dee, Nick, Goldy, Jeff, Smith, Kimberly A., Yao, Zizhen, Gradinaru, Viviana, Sunkin, Susan M., Lein, Ed S., Levi, Boaz P., Ting, Jonathan T., Zeng, Hongkui, Tasic, Bosiljka

Year: 2019

DOI: https://doi.org/10.1101/525014

Paper The Role of the Adeno-Associated Virus Capsid in Gene Transfer

Vliet, Kim Van, Blouin, Véronique, Brument, Nicole, Agbandje‐McKenna, Mavis, Snyder, Richard O. · 2008 · Methods in molecular biology · DOI

Full title: The Role of the Adeno-Associated Virus Capsid in Gene Transfer

Authors: Vliet, Kim Van, Blouin, Véronique, Brument, Nicole, Agbandje‐McKenna, Mavis, Snyder, Richard O.

Year: 2008

Venue: Methods in molecular biology

DOI: https://doi.org/10.1007/978-1-59745-210-6_2

Paper Production of recombinant vesicular stomatitis virus-based vectors by tangential flow depth filtration

Göbel, Sven, Pelz, Lars, Silva, Cristina A. T., Brühlmann, Béla, Hill, Charles E., Altomonte, Jennifer, Kamen, Amine, Reichl, Udo, Genzel, Yvonne · 2024 · Applied Microbiology and Biotechnology · DOI

Full title: Production of recombinant vesicular stomatitis virus-based vectors by tangential flow depth filtration

Authors: Göbel, Sven, Pelz, Lars, Silva, Cristina A. T., Brühlmann, Béla, Hill, Charles E., Altomonte, Jennifer, Kamen, Amine, Reichl, Udo, Genzel, Yvonne

Year: 2024

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-024-13078-6

Paper Capsid protein expression and adeno-associated virus like particles assembly in Saccharomyces cerevisiae.

Backovic, Ana, Cervelli, Tiziana, Salvetti, Alessandra, Zentilin, Lorena, Giacca, Mauro, Galli, Alvaro · 2012 · Microbial cell factories · DOI

Full title: Capsid protein expression and adeno-associated virus like particles assembly in Saccharomyces cerevisiae.

Authors: Backovic, Ana, Cervelli, Tiziana, Salvetti, Alessandra, Zentilin, Lorena, Giacca, Mauro, Galli, Alvaro

Year: 2012

Venue: Microbial cell factories

DOI: https://doi.org/10.1186/1475-2859-11-124

Paper AAVvector-mediated in vivo reprogramming into pluripotency.

Senís, Elena, Mosteiro, Lluc, Wilkening, Stefan, Wiedtke, Ellen, Nowrouzi, Ali, Afzal, Saira, Fronza, Raffaele, Landerer, Henrik, Abad, Maria, Niopek, Dominik, Schmidt, Manfred, Serrano, Manuel, Grimm, Dirk · 2018 · Nature communications · DOI

Full title: AAVvector-mediated in vivo reprogramming into pluripotency.

Authors: Senís, Elena, Mosteiro, Lluc, Wilkening, Stefan, Wiedtke, Ellen, Nowrouzi, Ali, Afzal, Saira, Fronza, Raffaele, Landerer, Henrik, Abad, Maria, Niopek, Dominik, Schmidt, Manfred, Serrano, Manuel, Grimm, Dirk

Year: 2018

Venue: Nature communications

DOI: https://doi.org/10.1038/s41467-018-05059-x

Paper Engineered retrovirus-like nanocarriers for messenger RNA delivery into neurons

Gu, Wenchao, Luozhong, Sijin, Cai, Simian, Londhe, Ketaki, Elkasri, Nadine, Hawkins, Robert D., Yuan, Zhefan, Su-Greene, Kai, Cruz, Mache, Chang, Yu‐Wei, McMullen, Patrick, Wu, Chunyan, Seo, Changwoo, Guru, Akash, Gao, Wenting, Sarmiento, Tara, Schaffer, Chris B., Nishimura, Nozomi, Cerione, Richard A., Warden, Melissa R., Langer, Robert, Jiang, Shaoyi · 2022 · DOI

Full title: Engineered retrovirus-like nanocarriers for messenger RNA delivery into neurons

Authors: Gu, Wenchao, Luozhong, Sijin, Cai, Simian, Londhe, Ketaki, Elkasri, Nadine, Hawkins, Robert D., Yuan, Zhefan, Su-Greene, Kai, Cruz, Mache, Chang, Yu‐Wei, McMullen, Patrick, Wu, Chunyan, Seo, Changwoo, Guru, Akash, Gao, Wenting, Sarmiento, Tara, Schaffer, Chris B., Nishimura, Nozomi, Cerione, Richard A., Warden, Melissa R., Langer, Robert, Jiang, Shaoyi

Year: 2022

DOI: https://doi.org/10.1101/2022.12.07.518870

Paper Receptor-targeted liposome-peptide-siRNA nanoparticles represent an efficient delivery system for MRTF silencing in conjunctival fibrosis

Yu‐Wai‐Man, Cynthia, Tagalakis, Aristides D., Manunta, Maria, Hart, Stephen L., Khaw, Peng T. · 2016 · Scientific Reports · DOI

Full title: Receptor-targeted liposome-peptide-siRNA nanoparticles represent an efficient delivery system for MRTF silencing in conjunctival fibrosis

Authors: Yu‐Wai‐Man, Cynthia, Tagalakis, Aristides D., Manunta, Maria, Hart, Stephen L., Khaw, Peng T.

Year: 2016

Venue: Scientific Reports

DOI: https://doi.org/10.1038/srep21881

Paper The membrane associated accessory protein is an adeno-associated viral egress factor

Elmore, Zachary C., Havlik, L. Patrick, Oh, Daniel K., Vincent, Heather A., Asokan, Aravind · 2021 · DOI

Full title: The membrane associated accessory protein is an adeno-associated viral egress factor

Authors: Elmore, Zachary C., Havlik, L. Patrick, Oh, Daniel K., Vincent, Heather A., Asokan, Aravind

Year: 2021

DOI: https://doi.org/10.1101/2021.06.17.448857

Paper Heterogeneity in an adeno-associated virus transfection-based production process limits the production efficiency.

Ladd, Brian, Tunmats, Sofia, Gräslund, Torbjörn, Daramola, Olalekan, Rockberg, Johan, Chotteau, Véronique · 2025 · Scientific reports · DOI

Full title: Heterogeneity in an adeno-associated virus transfection-based production process limits the production efficiency.

Authors: Ladd, Brian, Tunmats, Sofia, Gräslund, Torbjörn, Daramola, Olalekan, Rockberg, Johan, Chotteau, Véronique

Year: 2025

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-025-26261-0

Paper Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington's disease.

Wu, Zheng, Parry, Matthew, Hou, Xiao-Yi, Liu, Min-Hui, Wang, Hui, Cain, Rachel, Pei, Zi-Fei, Chen, Yu-Chen, Guo, Zi-Yuan, Abhijeet, Sambangi, Chen, Gong · 2020 · Nature communications · DOI

Full title: Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington's disease.

Authors: Wu, Zheng, Parry, Matthew, Hou, Xiao-Yi, Liu, Min-Hui, Wang, Hui, Cain, Rachel, Pei, Zi-Fei, Chen, Yu-Chen, Guo, Zi-Yuan, Abhijeet, Sambangi, Chen, Gong

Year: 2020

Venue: Nature communications

DOI: https://doi.org/10.1038/s41467-020-14855-3

Paper Utilizing minimally purified secreted rAAV for rapid and cost-effective manipulation of gene expression in the CNS.

Goodwin, Marshall S, Croft, Cara L, Futch, Hunter S, Ryu, Daniel, Ceballos-Diaz, Carolina, Liu, Xuefei, Paterno, Giavanna, Mejia, Catalina, Deng, Doris, Menezes, Kimberly, Londono, Laura, Arjona, Kefren, Parianos, Mary, Truong, Van, Rostonics, Eva, Hernandez, Amanda, Boye, Sanford L, Boye, Shannon E, Levites, Yona, Cruz, Pedro E, Golde, Todd E · 2020 · Molecular neurodegeneration · DOI

Full title: Utilizing minimally purified secreted rAAV for rapid and cost-effective manipulation of gene expression in the CNS.

Authors: Goodwin, Marshall S, Croft, Cara L, Futch, Hunter S, Ryu, Daniel, Ceballos-Diaz, Carolina, Liu, Xuefei, Paterno, Giavanna, Mejia, Catalina, Deng, Doris, Menezes, Kimberly, Londono, Laura, Arjona, Kefren, Parianos, Mary, Truong, Van, Rostonics, Eva, Hernandez, Amanda, Boye, Sanford L, Boye, Shannon E, Levites, Yona, Cruz, Pedro E, Golde, Todd E

Year: 2020

Venue: Molecular neurodegeneration

DOI: https://doi.org/10.1186/s13024-020-00361-z

Paper Advanced biomanufacturing and evaluation of adeno-associated virus

Chen, Kai, Kim, Seulhee, Yang, Siying, Varadkar, Tanvi, Zhou, Zhuoxin “Zora”, Zhang, Jiashuai, Zhou, Lufang, Liu, Margaret · 2024 · Journal of Biological Engineering · DOI

Full title: Advanced biomanufacturing and evaluation of adeno-associated virus

Authors: Chen, Kai, Kim, Seulhee, Yang, Siying, Varadkar, Tanvi, Zhou, Zhuoxin “Zora”, Zhang, Jiashuai, Zhou, Lufang, Liu, Margaret

Year: 2024

Venue: Journal of Biological Engineering

DOI: https://doi.org/10.1186/s13036-024-00409-4

Paper Characterization of Extracellular Vesicles Secreted in Lentiviral Producing HEK293SF Cell Cultures

Minh, Aline Do, Star, Alexandra T., Stupak, Jacek, Gélinas, Jean‐François, Li, Jianjun, Twine, Susan M., Kamen, Amine · 2021 · Preprints.org · DOI

Full title: Characterization of Extracellular Vesicles Secreted in Lentiviral Producing HEK293SF Cell Cultures

Authors: Minh, Aline Do, Star, Alexandra T., Stupak, Jacek, Gélinas, Jean‐François, Li, Jianjun, Twine, Susan M., Kamen, Amine

Year: 2021

Venue: Preprints.org

DOI: https://doi.org/10.20944/preprints202103.0696.v1

Paper AAV8 vector induced gliosis following neuronal transgene expression.

McLeod, Faye, McDermott, Elaine, Mak, Shermin, Walsh, Darren, Turnbull, Mark, LeBeau, Fiona E N, Jackson, Andrew, Trevelyan, Andrew J, Clowry, Gavin J · 2024 · Frontiers in neuroscience · DOI

Full title: AAV8 vector induced gliosis following neuronal transgene expression.

Authors: McLeod, Faye, McDermott, Elaine, Mak, Shermin, Walsh, Darren, Turnbull, Mark, LeBeau, Fiona E N, Jackson, Andrew, Trevelyan, Andrew J, Clowry, Gavin J

Year: 2024

Venue: Frontiers in neuroscience

DOI: https://doi.org/10.3389/fnins.2024.1287228

Paper A single dose recombinant AAV based CHIKV vaccine elicits robust and durable protective antibody responses in mice.

Zhu, Qin-Xuan, Zhang, Ya-Nan, Zhang, Hong-Qing, Leng, Chao, Deng, Cheng-Lin, Wang, Xin, Li, Jia-Jia, Ye, Xiang-Li, Zhang, Bo, Li, Xiao-Dan · 2024 · PLoS neglected tropical diseases · DOI

Full title: A single dose recombinant AAV based CHIKV vaccine elicits robust and durable protective antibody responses in mice.

Authors: Zhu, Qin-Xuan, Zhang, Ya-Nan, Zhang, Hong-Qing, Leng, Chao, Deng, Cheng-Lin, Wang, Xin, Li, Jia-Jia, Ye, Xiang-Li, Zhang, Bo, Li, Xiao-Dan

Year: 2024

Venue: PLoS neglected tropical diseases

DOI: https://doi.org/10.1371/journal.pntd.0012604

Paper Engineering a synthetic gene circuit for high-performance inducible expression in mammalian systems

Carluccio, Giuliano De, Fusco, Virginia, Bernardo, Diego di · 2024 · Nature Communications · DOI

Full title: Engineering a synthetic gene circuit for high-performance inducible expression in mammalian systems

Authors: Carluccio, Giuliano De, Fusco, Virginia, Bernardo, Diego di

Year: 2024

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-024-47592-y

Paper Enhanced ER protein processing gene expression increases rAAV yield and full capsid ratio in HEK293 cells.

Fu, Qiang, Wang, Yongdan, Qin, Jiansong, Xie, Dongming, McNally, David, Yoon, Seongkyu · 2024 · Applied microbiology and biotechnology · DOI

Full title: Enhanced ER protein processing gene expression increases rAAV yield and full capsid ratio in HEK293 cells.

Authors: Fu, Qiang, Wang, Yongdan, Qin, Jiansong, Xie, Dongming, McNally, David, Yoon, Seongkyu

Year: 2024

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-024-13281-5

Paper Adenoviral vectors for cardiovascular gene therapy applications: a clinical and industry perspective

Schwartze, Julian Tristan, Havenga, Menzo, Bakker, Wilfried A.M., Bradshaw, Angela C., Nicklin, Stuart A. · 2022 · Journal of Molecular Medicine · DOI

Full title: Adenoviral vectors for cardiovascular gene therapy applications: a clinical and industry perspective

Authors: Schwartze, Julian Tristan, Havenga, Menzo, Bakker, Wilfried A.M., Bradshaw, Angela C., Nicklin, Stuart A.

Year: 2022

Venue: Journal of Molecular Medicine

DOI: https://doi.org/10.1007/s00109-022-02208-0

Paper Production of Adeno-Associated Virus Vector Serotype rh.10 and Optimization of Its Purification via Chloroform Extraction.

Tamura, Naoki, Suzuki, Kanzo, Shiraki, Hirono, Waguri, Issei, Segi-Nishida, Eri · 2025 · Biological & pharmaceutical bulletin · DOI

Full title: Production of Adeno-Associated Virus Vector Serotype rh.10 and Optimization of Its Purification via Chloroform Extraction.

Authors: Tamura, Naoki, Suzuki, Kanzo, Shiraki, Hirono, Waguri, Issei, Segi-Nishida, Eri

Year: 2025

Venue: Biological & pharmaceutical bulletin

DOI: https://doi.org/10.1248/bpb.b24-00850

Paper Chitosan-DNA/siRNA Nanoparticles for Gene Therapy

Shi, Qin, Marcio, J., Zhang, Xiaoling, Dai, Kerong, Benderdour, Mohamed, Polonio, Júlio César · 2011 · InTech eBooks · DOI

Full title: Chitosan-DNA/siRNA Nanoparticles for Gene Therapy

Authors: Shi, Qin, Marcio, J., Zhang, Xiaoling, Dai, Kerong, Benderdour, Mohamed, Polonio, Júlio César

Year: 2011

Venue: InTech eBooks

DOI: https://doi.org/10.5772/21903

Paper LentiPro26: novel stable cell lines for constitutive lentiviral vector production

Tomás, Hélio A., Rodrigues, Ana F., Carrondo, Manuel J.T., Coroadinha, Ana S. · 2018 · Scientific Reports · DOI

Full title: LentiPro26: novel stable cell lines for constitutive lentiviral vector production

Authors: Tomás, Hélio A., Rodrigues, Ana F., Carrondo, Manuel J.T., Coroadinha, Ana S.

Year: 2018

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-018-23593-y

Paper Production of retroviral vectors in continuous high cell density culture

Hein, Marc D., Kazenmaier, Daniel, Heuvel, Yasemin van, Dogra, Tanya, Cattaneo, Maurizio, Kupke, Sascha Young, Stitz, Jörn, Genzel, Yvonne, Reichl, Udo · 2023 · Applied Microbiology and Biotechnology · DOI

Full title: Production of retroviral vectors in continuous high cell density culture

Authors: Hein, Marc D., Kazenmaier, Daniel, Heuvel, Yasemin van, Dogra, Tanya, Cattaneo, Maurizio, Kupke, Sascha Young, Stitz, Jörn, Genzel, Yvonne, Reichl, Udo

Year: 2023

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-023-12689-9

Paper AAV9-mediated gene delivery to liver grafts during static cold storage in a rat liver transplant model.

Gao, Qimeng, Kesseli, Samuel J, Gonzalez, Trevor, Zhang, Min, Kahan, Riley, Krischak, Madison, Halpern, Samantha E, Song, Mingqing, Xu, Hongzhi, Abraham, Nader, Anwar, Imran J, Alderete, Isaac, Asokan, Aravind, Hartwig, Matthew G, Barbas, Andrew S · 2023 · Frontiers in transplantation · DOI

Full title: AAV9-mediated gene delivery to liver grafts during static cold storage in a rat liver transplant model.

Authors: Gao, Qimeng, Kesseli, Samuel J, Gonzalez, Trevor, Zhang, Min, Kahan, Riley, Krischak, Madison, Halpern, Samantha E, Song, Mingqing, Xu, Hongzhi, Abraham, Nader, Anwar, Imran J, Alderete, Isaac, Asokan, Aravind, Hartwig, Matthew G, Barbas, Andrew S

Year: 2023

Venue: Frontiers in transplantation

DOI: https://doi.org/10.3389/frtra.2023.1171272

Paper Polyethylenimine based magnetic nanoparticles mediated non-viral CRISPR/Cas9 system for genome editing

Rohiwal, Sonali S., Dvořáková, Nikola, Klı́ma, Jiřı́, Vaškovičová, Michaela, Šenigl, Filip, Šlouf, Miroslav, Pavlová, Ewa, Štěpánek, Petr, Babuka, David, Beneš, Hynek, Ellederová, Zdeňka, Stieger, Knut · 2020 · Scientific Reports · DOI

Full title: Polyethylenimine based magnetic nanoparticles mediated non-viral CRISPR/Cas9 system for genome editing

Authors: Rohiwal, Sonali S., Dvořáková, Nikola, Klı́ma, Jiřı́, Vaškovičová, Michaela, Šenigl, Filip, Šlouf, Miroslav, Pavlová, Ewa, Štěpánek, Petr, Babuka, David, Beneš, Hynek, Ellederová, Zdeňka, Stieger, Knut

Year: 2020

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-020-61465-6

Paper Enhanced Transgene Expression from Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell Lines In Vitro and in Murine Hepatocytes In Vivo

Chen, Ling, Wang, Yuan, Yuan, Lu, Wang, Lina, Jayandharan, Giridhara R., Aslanidi, George, Li, Baozheng, Cheng, Binbin, Ma, Wenqin, Lentz, Thomas, Ling, Changquan, Xiao, Xiao, Samulski, R. Jude, Muzyczka, Nicholas, Srivastava, Arun · 2020 · UNC Libraries · DOI

Full title: Enhanced Transgene Expression from Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell Lines In Vitro and in Murine Hepatocytes In Vivo

Authors: Chen, Ling, Wang, Yuan, Yuan, Lu, Wang, Lina, Jayandharan, Giridhara R., Aslanidi, George, Li, Baozheng, Cheng, Binbin, Ma, Wenqin, Lentz, Thomas, Ling, Changquan, Xiao, Xiao, Samulski, R. Jude, Muzyczka, Nicholas, Srivastava, Arun

Year: 2020

Venue: UNC Libraries

DOI: https://doi.org/10.17615/7w6y-pk12

Paper The CASwitch: a synthetic biology solution for high-performance inducible gene expression systems in biotechnology

Carluccio, Giuliano De, Fusco, Virginia, Bernardo, Diego di · 2023 · DOI

Full title: The CASwitch: a synthetic biology solution for high-performance inducible gene expression systems in biotechnology

Authors: Carluccio, Giuliano De, Fusco, Virginia, Bernardo, Diego di

Year: 2023

DOI: https://doi.org/10.1101/2023.09.20.558637

Paper Rapid establishment of a HEK 293 cell line expressing FVIII-BDD using AAV site-specific integration plasmids.

Liu, Xiaomei, Ping, Han, Zhang, Chun · 2014 · BMC research notes · DOI

Full title: Rapid establishment of a HEK 293 cell line expressing FVIII-BDD using AAV site-specific integration plasmids.

Authors: Liu, Xiaomei, Ping, Han, Zhang, Chun

Year: 2014

Venue: BMC research notes

DOI: https://doi.org/10.1186/1756-0500-7-626

Paper Untitled

Ornek, Dogan, Sayed, Nida, Sousa, Matthew, Crue, Connor, Chari, Ravi, Delzell, Stephanie, Cardoso, Adalia, Lin, Roy, Ramsey, Philip, Erler, A, Mas, N De, Ramsey, P, Henderson, G, Ramsey, P, Lemkus, T, Ramsey, P, Gotwalt, C, Weese, M, Gotwalt, C, Xu, L, Hong, Y, Meeker, W, Zhao, H, Lee, K, Daris, M, Lin, Y, Wolfe, T, Sheng, J, Plewa, C, Wang, S, Meisen, W, Moo, P, Xu, X, Silva, C, Kamen, A, Guan, J, Chen, K, Si, Y, Kim, Zhou, Z, Kim, S, Zhou, L, Liu, X, Kontogiannis, T, Braybrook, J, Mcelroy, C, Foy, C, Whale, A, Quaglia, M, Smales, C, Grieger, J, Soltys, S, Samulski, R, Fu, Q, Lee, Y, Green, E, Wang, Y, Park, S, Polanco, A, Lee, K, Betenbaugh, M, Mcnally, D, Yoon, S, Philip, J · 2025 · BioProcessing Journal · DOI

Full title: Untitled

Authors: Ornek, Dogan, Sayed, Nida, Sousa, Matthew, Crue, Connor, Chari, Ravi, Delzell, Stephanie, Cardoso, Adalia, Lin, Roy, Ramsey, Philip, Erler, A, Mas, N De, Ramsey, P, Henderson, G, Ramsey, P, Lemkus, T, Ramsey, P, Gotwalt, C, Weese, M, Gotwalt, C, Xu, L, Hong, Y, Meeker, W, Zhao, H, Lee, K, Daris, M, Lin, Y, Wolfe, T, Sheng, J, Plewa, C, Wang, S, Meisen, W, Moo, P, Xu, X, Silva, C, Kamen, A, Guan, J, Chen, K, Si, Y, Kim, Zhou, Z, Kim, S, Zhou, L, Liu, X, Kontogiannis, T, Braybrook, J, Mcelroy, C, Foy, C, Whale, A, Quaglia, M, Smales, C, Grieger, J, Soltys, S, Samulski, R, Fu, Q, Lee, Y, Green, E, Wang, Y, Park, S, Polanco, A, Lee, K, Betenbaugh, M, Mcnally, D, Yoon, S, Philip, J

Year: 2025

Venue: BioProcessing Journal

DOI: https://doi.org/10.12665/j24oa-ornek

Paper Molecular design for recombinant adeno-associated virus (rAAV) vector production

Aponte, Juan José, Barajas, Daniel, Peltier, Joseph, Bardliving, Cameron, Shamlou, P. Ayazi, Gold, Daniel · 2017 · Applied Microbiology and Biotechnology · DOI

Full title: Molecular design for recombinant adeno-associated virus (rAAV) vector production

Authors: Aponte, Juan José, Barajas, Daniel, Peltier, Joseph, Bardliving, Cameron, Shamlou, P. Ayazi, Gold, Daniel

Year: 2017

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-017-8670-1

Paper Peer Review #1 of "Transfection types, methods and strategies: a technical review (v0.3)"

Chong, Zhi Xiong, Keong, Swee, Yong, Wan, Corresp, Ho, Ho, Wan Yong, Ahmadzada, T, Reid, G, Mckenzie, D, Al-Dosari, M, Gao, X, Alabdullah, A, Al-Abdulaziz, B, Alsalem, H, Magrashi, A, Pulicat, S, Almzroua, A, Almohanna, F, Assiri, A, Tassan, N Al, Al-Mubarak, B, Aldred, S, Collins, P, Trinklein, N, Allison, S, Milner, J, Arnold, A, Laporte, V, Dumont, S, Appert-Collin, A, Erbacher, P, Coupin, G, Levy, R, Poindron, P, Gies, J, Ayub, S, Ling, F, Too, See, Cun, W, Balak, J, Graaf, N De, Zaldumbide, A, Rabelink, T, Hoeben, R, Koning, E De, Carlotti, F, Balazs, D, Godbey, W, Basiouni, S, Fuhrmann, H, Schumann, J, Bauler, M, Roberts, J, Wu, C.-C, Fan, B, Ferrara, F, Yip, B, Diao, S, Kim, Y.-I, Moore, J, Zhou, S, Wielgosz, M, Ryu, B, Throm, R, Bell, N, Micklefield, J, Borawski, J, Lindeman, A, Buxton, F, Labow, M, Gaither, L, Brunner, S, Sauer, T, Carotta, S, Cotten, M, Saltik, M, Wagner, E, Canoy, R, Andr, F, Shmakova, A, Wiels, J, Lipinski, M, Vassetzky, Y, Germini, D, Cao, E, Chen, Y, Cui, Z, Foster, P, Chan, J, Krichevsky, A, Kosik, K, Chen, X, Gu, S, Chen, B.-F, Shen, W.-L, Yin, Z, Xu, G.-W, Hu, J.-J, Zhu, T, Li, G, Wan, C · 2021 · DOI

Full title: Peer Review #1 of "Transfection types, methods and strategies: a technical review (v0.3)"

Authors: Chong, Zhi Xiong, Keong, Swee, Yong, Wan, Corresp, Ho, Ho, Wan Yong, Ahmadzada, T, Reid, G, Mckenzie, D, Al-Dosari, M, Gao, X, Alabdullah, A, Al-Abdulaziz, B, Alsalem, H, Magrashi, A, Pulicat, S, Almzroua, A, Almohanna, F, Assiri, A, Tassan, N Al, Al-Mubarak, B, Aldred, S, Collins, P, Trinklein, N, Allison, S, Milner, J, Arnold, A, Laporte, V, Dumont, S, Appert-Collin, A, Erbacher, P, Coupin, G, Levy, R, Poindron, P, Gies, J, Ayub, S, Ling, F, Too, See, Cun, W, Balak, J, Graaf, N De, Zaldumbide, A, Rabelink, T, Hoeben, R, Koning, E De, Carlotti, F, Balazs, D, Godbey, W, Basiouni, S, Fuhrmann, H, Schumann, J, Bauler, M, Roberts, J, Wu, C.-C, Fan, B, Ferrara, F, Yip, B, Diao, S, Kim, Y.-I, Moore, J, Zhou, S, Wielgosz, M, Ryu, B, Throm, R, Bell, N, Micklefield, J, Borawski, J, Lindeman, A, Buxton, F, Labow, M, Gaither, L, Brunner, S, Sauer, T, Carotta, S, Cotten, M, Saltik, M, Wagner, E, Canoy, R, Andr, F, Shmakova, A, Wiels, J, Lipinski, M, Vassetzky, Y, Germini, D, Cao, E, Chen, Y, Cui, Z, Foster, P, Chan, J, Krichevsky, A, Kosik, K, Chen, X, Gu, S, Chen, B.-F, Shen, W.-L, Yin, Z, Xu, G.-W, Hu, J.-J, Zhu, T, Li, G, Wan, C

Year: 2021

DOI: https://doi.org/10.7287/peerj.11165v0.3/reviews/1

Paper Evolving Membrane-Associated Accessory Protein Variants for Improved Adeno-associated Virus Production

Schieferecke, Adam J., Lee, Hyun‐Cheol, Chen, Aleysha T., Kilaru, Vindhya, Williams, Justin Krish, Schaffer, David V. · 2023 · DOI

Full title: Evolving Membrane-Associated Accessory Protein Variants for Improved Adeno-associated Virus Production

Authors: Schieferecke, Adam J., Lee, Hyun‐Cheol, Chen, Aleysha T., Kilaru, Vindhya, Williams, Justin Krish, Schaffer, David V.

Year: 2023

DOI: https://doi.org/10.1101/2023.07.18.549400

Paper Adeno-associated virus capsid assembly is divergent and stochastic

Wörner, Tobias P., Bennett, Antonette, Habka, Sana, Snijder, Joost, Friese, Olga, Powers, Thomas W., Agbandje‐McKenna, Mavis, Heck, Albert J. R. · 2021 · Nature Communications · DOI

Full title: Adeno-associated virus capsid assembly is divergent and stochastic

Authors: Wörner, Tobias P., Bennett, Antonette, Habka, Sana, Snijder, Joost, Friese, Olga, Powers, Thomas W., Agbandje‐McKenna, Mavis, Heck, Albert J. R.

Year: 2021

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-021-21935-5

Paper Intranasal gene therapy to prevent infection by SARS-CoV-2 variants

Sims, Joshua J., Greig, Jenny A., Michalson, Kristofer T., Lian, Sharon, Martino, Recchia, Meggersee, Rosemary, Turner, Kevin B., Nambiar, Kalyani, Dyer, Cecilia, Hinderer, Christian, Horiuchi, Makoto, Yan, Hanying, Huang, Xin, Chen, Shu‐Jen, Wilson, James M. · 2021 · DOI

Full title: Intranasal gene therapy to prevent infection by SARS-CoV-2 variants

Authors: Sims, Joshua J., Greig, Jenny A., Michalson, Kristofer T., Lian, Sharon, Martino, Recchia, Meggersee, Rosemary, Turner, Kevin B., Nambiar, Kalyani, Dyer, Cecilia, Hinderer, Christian, Horiuchi, Makoto, Yan, Hanying, Huang, Xin, Chen, Shu‐Jen, Wilson, James M.

Year: 2021

DOI: https://doi.org/10.1101/2021.04.09.439149

Paper Targeted overexpression of relaxin receptor 1 (RXFP1) with chronic administration of relaxin as a novel inotropic approach for heart failure treatment

Sasipong, Nuttarak · 2020 · heiDOK (Heidelberg University) · DOI

Full title: Targeted overexpression of relaxin receptor 1 (RXFP1) with chronic administration of relaxin as a novel inotropic approach for heart failure treatment

Authors: Sasipong, Nuttarak

Year: 2020

Venue: heiDOK (Heidelberg University)

DOI: https://doi.org/10.11588/heidok.00027301

Paper Quantitative analysis of preferential utilization of AAV ITR as the packaging terminal signal.

Li, Xin, Miller, Lohra Mickelle, Chrzanowski, Matthew, Tian, Jiahe, Jarrold, Martin F, Herzog, Roland W, Xiao, Weidong, Draper, Benjamin, Zhang, Junping · 2023 · Frontiers in bioengineering and biotechnology · DOI

Full title: Quantitative analysis of preferential utilization of AAV ITR as the packaging terminal signal.

Authors: Li, Xin, Miller, Lohra Mickelle, Chrzanowski, Matthew, Tian, Jiahe, Jarrold, Martin F, Herzog, Roland W, Xiao, Weidong, Draper, Benjamin, Zhang, Junping

Year: 2023

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2023.1327433

Paper Rational design of a compact CRISPR-Cas9 activator for AAV-mediated delivery

Vora, Suhani, Cheng, Jenny, Xiao, Ru, VanDusen, Nathan J., Quintino, Luís, Pu, William T., Vandenberghe, Luk H., Chavez, Alejandro, Church, George M. · 2018 · DOI

Full title: Rational design of a compact CRISPR-Cas9 activator for AAV-mediated delivery

Authors: Vora, Suhani, Cheng, Jenny, Xiao, Ru, VanDusen, Nathan J., Quintino, Luís, Pu, William T., Vandenberghe, Luk H., Chavez, Alejandro, Church, George M.

Year: 2018

DOI: https://doi.org/10.1101/298620

Paper Directed evolution of AAV capsids for improved efficacy and specificity of delivery to preclinical models of human liver

Kwiatek, Magdalena, Michalski, Aleksander, Abramowicz, Karolina, Rutyna, Paweł, Wasiak, Magdalena, Reichert, M., Lisowski, Leszek · 2023 · Lekarz Wojskowy · DOI

Full title: Directed evolution of AAV capsids for improved efficacy and specificity of delivery to preclinical models of human liver

Authors: Kwiatek, Magdalena, Michalski, Aleksander, Abramowicz, Karolina, Rutyna, Paweł, Wasiak, Magdalena, Reichert, M., Lisowski, Leszek

Year: 2023

Venue: Lekarz Wojskowy

DOI: https://doi.org/10.53301/lw/156374

Paper Abstracts from the 25th European Society for Animal Cell Technology Meeting: Cell Technologies for Innovative Therapies

Andréa, Mc Cann,, Grégory, Mathy,, Laetitia, Malphettes, · 2018 · BMC Proceedings · DOI

Full title: Abstracts from the 25th European Society for Animal Cell Technology Meeting: Cell Technologies for Innovative Therapies

Authors: Andréa, Mc Cann,, Grégory, Mathy,, Laetitia, Malphettes,

Year: 2018

Venue: BMC Proceedings

DOI: https://doi.org/10.1186/s12919-018-0097-x

Paper Adeno-associated virus capsid assembly is divergent and stochastic

Wörner, Tobias P., Bennett, Antonette, Habka, Sana, Snijder, Joost, Friese, Olga, Powers, Thomas W., Agbandje‐McKenna, Mavis, Heck, Albert J. R. · 2020 · DOI

Full title: Adeno-associated virus capsid assembly is divergent and stochastic

Authors: Wörner, Tobias P., Bennett, Antonette, Habka, Sana, Snijder, Joost, Friese, Olga, Powers, Thomas W., Agbandje‐McKenna, Mavis, Heck, Albert J. R.

Year: 2020

DOI: https://doi.org/10.1101/2020.10.09.332619

Paper Development of a perfusion process for serum-free adenovirus vector herpes zoster vaccine production

Sun, Yang, Huang, Lingling, Nie, Jianqi, Feng, Kai, Liu, Yupeng, Bai, Zhonghu · 2022 · AMB Express · DOI

Full title: Development of a perfusion process for serum-free adenovirus vector herpes zoster vaccine production

Authors: Sun, Yang, Huang, Lingling, Nie, Jianqi, Feng, Kai, Liu, Yupeng, Bai, Zhonghu

Year: 2022

Venue: AMB Express

DOI: https://doi.org/10.1186/s13568-022-01398-7

Paper Production of Lentiviral Vectors Encoding Recombinant Factor VIII Expression in Serum-Free Suspension Cultures

Caron, Angelo Luis, Picanço‐Castro, Virgínia, Ansorge, Sven, Covas, Dimas Tadeu, Kamen, Amine, Swiech, Kamilla · 2015 · Brazilian Archives of Biology and Technology · DOI

Full title: Production of Lentiviral Vectors Encoding Recombinant Factor VIII Expression in Serum-Free Suspension Cultures

Authors: Caron, Angelo Luis, Picanço‐Castro, Virgínia, Ansorge, Sven, Covas, Dimas Tadeu, Kamen, Amine, Swiech, Kamilla

Year: 2015

Venue: Brazilian Archives of Biology and Technology

DOI: https://doi.org/10.1590/s1516-89132015060367

Paper Molecular barcoding of viral vectors enables mapping and optimization of mRNAtrans-splicing

Davidsson, Marcus, Díaz-Fernández, Paula, Torroba, Marcos, Schwich, Oliver Daniel, Aldrin-Kirk, Patrick, Quintino, Luís, Heuer, Andreas, Wang, Gang, Lundberg, Cecilia, Björklund, Tomas · 2018 · RNA · DOI

Full title: Molecular barcoding of viral vectors enables mapping and optimization of mRNAtrans-splicing

Authors: Davidsson, Marcus, Díaz-Fernández, Paula, Torroba, Marcos, Schwich, Oliver Daniel, Aldrin-Kirk, Patrick, Quintino, Luís, Heuer, Andreas, Wang, Gang, Lundberg, Cecilia, Björklund, Tomas

Year: 2018

Venue: RNA

DOI: https://doi.org/10.1261/rna.063925.117

Paper Pharmaceutical Development of AAV-Based Gene Therapy Products for the Eye

Rodrigues, Gerard A., Shalaev, Evgenyi, Karami, Thomas K., Cunningham, James M., Slater, Nigel K.H., Rivers, Hongwen M. · 2018 · Pharmaceutical Research · DOI

Full title: Pharmaceutical Development of AAV-Based Gene Therapy Products for the Eye

Authors: Rodrigues, Gerard A., Shalaev, Evgenyi, Karami, Thomas K., Cunningham, James M., Slater, Nigel K.H., Rivers, Hongwen M.

Year: 2018

Venue: Pharmaceutical Research

DOI: https://doi.org/10.1007/s11095-018-2554-7

Paper Efficacy and Safety of rAAV2-ND4 Treatment for Leber's Hereditary Optic Neuropathy.

Wan, Xing, Pei, Han, Zhao, Min-jian, Yang, Shuo, Hu, Wei-kun, He, Heng, Ma, Si-qi, Zhang, Ge, Dong, Xiao-yan, Chen, Chen, Wang, Dao-wen, Li, Bin · 2016 · Scientific reports · DOI

Full title: Efficacy and Safety of rAAV2-ND4 Treatment for Leber's Hereditary Optic Neuropathy.

Authors: Wan, Xing, Pei, Han, Zhao, Min-jian, Yang, Shuo, Hu, Wei-kun, He, Heng, Ma, Si-qi, Zhang, Ge, Dong, Xiao-yan, Chen, Chen, Wang, Dao-wen, Li, Bin

Year: 2016

Venue: Scientific reports

DOI: https://doi.org/10.1038/srep21587

Paper Two-Step Small Scale Purification of Recombinant Adeno-Associated Viruses

Chen, Shih‐Heng, Papaneri, Amy B., Walker, Mitzie, Scappini, Erica, Keys, Robert D., Martin, Negin P. · 2019 · PLOS ONE · DOI

Full title: Two-Step Small Scale Purification of Recombinant Adeno-Associated Viruses

Authors: Chen, Shih‐Heng, Papaneri, Amy B., Walker, Mitzie, Scappini, Erica, Keys, Robert D., Martin, Negin P.

Year: 2019

Venue: PLOS ONE

DOI: https://doi.org/10.1101/715029

Paper Culture media selection and feeding strategy for high titer production of a lentiviral vector by stable producer clones cultivated at high cell density

Shen, Chun Fang, Tremblay, Sonia, Sabourin-Poirier, Catherine, Burney, Elodie, Broussau, Sophie, Manceur, Aziza, Rodenbrock, Anja, Voyer, Robert, Loignon, Martin, Ansorge, Sven, Gilbert, Rénald · 2022 · Bioprocess and Biosystems Engineering · DOI

Full title: Culture media selection and feeding strategy for high titer production of a lentiviral vector by stable producer clones cultivated at high cell density

Authors: Shen, Chun Fang, Tremblay, Sonia, Sabourin-Poirier, Catherine, Burney, Elodie, Broussau, Sophie, Manceur, Aziza, Rodenbrock, Anja, Voyer, Robert, Loignon, Martin, Ansorge, Sven, Gilbert, Rénald

Year: 2022

Venue: Bioprocess and Biosystems Engineering

DOI: https://doi.org/10.1007/s00449-022-02737-5

Paper Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer's disease neuropathology.

Chen, Fading, Swartzlander, Dan B, Ghosh, Anamitra, Fryer, John D, Wang, Baiping, Zheng, Hui · 2021 · Molecular neurodegeneration · DOI

Full title: Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer's disease neuropathology.

Authors: Chen, Fading, Swartzlander, Dan B, Ghosh, Anamitra, Fryer, John D, Wang, Baiping, Zheng, Hui

Year: 2021

Venue: Molecular neurodegeneration

DOI: https://doi.org/10.1186/s13024-021-00426-7

Thesis Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation

Jordan, M.; Schallhorn, A.; Wurm, F. M. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation

Authors: Jordan, M.; Schallhorn, A.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7661

Thesis Highly efficient Cas9 mediated transcriptional programming and delivery via Adeno-Associated Virus

Vora, Suhani · 2017 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Highly efficient Cas9 mediated transcriptional programming and delivery via Adeno-Associated Virus

Authors: Vora, Suhani

Year: 2017

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/112508

Thesis AAV-Vectored Immunoprophylaxis for the Prevention and Treatment of Infectious Diseases

Rghei, Amira · 2022 · University of Guelph · DOI

Full title: AAV-Vectored Immunoprophylaxis for the Prevention and Treatment of Infectious Diseases

Authors: Rghei, Amira

Year: 2022

Venue: University of Guelph

DOI: https://hdl.handle.net/10214/27116

Thesis Alleviation of shRNA off-target effects via rAAV vector-encoded sense strand decoys

Mockenhaupt, Stefan · 2012 · Heidelberg University · DOI

Full title: Alleviation of shRNA off-target effects via rAAV vector-encoded sense strand decoys

Authors: Mockenhaupt, Stefan

Year: 2012

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/13390/1/Mockenhaupt_PhD_thesis_final.pdf

Thesis Development and characterization of an improved formulation of cholesteryl oleate-loaded cationic solid-lipid nanoparticles as an efficient non-viral gene delivery system

Limeres, María José; Suñé-Pou, Marc; Prieto-Sánchez, Silvia et al. · 2019 · National University of La Plata – SeDiCI · DOI

Full title: Development and characterization of an improved formulation of cholesteryl oleate-loaded cationic solid-lipid nanoparticles as an efficient non-viral gene delivery system

Authors: Limeres, María José; Suñé-Pou, Marc; Prieto-Sánchez, Silvia; Moreno-Castro, Cristina; Nusblat, Alejandro D.; Hernández-Munain, Cristina; Castro, Guillermo Raúl; Suñé, Carlos; Suñé-Negre, Josep M.; Cuestas, María Luján

Year: 2019

Venue: National University of La Plata – SeDiCI

DOI: http://sedici.unlp.edu.ar/handle/10915/139683

Thesis Efficacy and toxicity of linear polyamidoamine polymers used in gene delivery

Almulathanon, Ammar · 2018 · University of Nottingham · DOI

Full title: Efficacy and toxicity of linear polyamidoamine polymers used in gene delivery

Authors: Almulathanon, Ammar

Year: 2018

Venue: University of Nottingham

DOI: https://eprints.nottingham.ac.uk/49894/1/Ammar%20thesis.pdf

Thesis In vitro and ex vivo strategies for intracellular delivery

Sahay, Gaurav; Stewart, Martin P; Sharei, Armon Reza et al. · 2017 · Massachusetts Institute of Technology (MIT) · DOI

Full title: In vitro and ex vivo strategies for intracellular delivery

Authors: Sahay, Gaurav; Stewart, Martin P; Sharei, Armon Reza; Ding, Xiaoyun Sean; Langer, Robert S; Jensen, Klavs F

Year: 2017

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/110923

Thesis Endogenous UMIs as quantifiable reporter elements – validation studies & applications in rAAV vectorology

Wilmott, Patrick Gurney · 2023 · University of Sydney · DOI

Full title: Endogenous UMIs as quantifiable reporter elements – validation studies & applications in rAAV vectorology

Authors: Wilmott, Patrick Gurney

Year: 2023

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/31622

Thesis Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022 · KTH Royal Institute of Technology · DOI

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

Year: 2022

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis Vergleich dreier Vektorsysteme für den koronaren Gentransfer

Sack, Philipp Andreas · 2010 · Technical University of Munich · DOI

Full title: Vergleich dreier Vektorsysteme für den koronaren Gentransfer

Authors: Sack, Philipp Andreas

Year: 2010

Venue: Technical University of Munich

DOI: https://mediatum.ub.tum.de/602308

Thesis Improving AAV Retinal Gene Therapy for Batten Disease

Schwartz, Maura Katherine · 2022 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Improving AAV Retinal Gene Therapy for Batten Disease

Authors: Schwartz, Maura Katherine

Year: 2022

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1669911156168454

Thesis Rekombinante Hepatitis B Viren-Vektoren als Werkzeuge für Molekularbiologie und Therapie : Optimierung eines Systems

Untergasser, Andreas · 2003 · Heidelberg University · DOI

Full title: Rekombinante Hepatitis B Viren-Vektoren als Werkzeuge für Molekularbiologie und Therapie : Optimierung eines Systems

Authors: Untergasser, Andreas

Year: 2003

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/3121/1/Promotion.pdf

Thesis LARGE GENE DELIVERY TO THE RETINA BY MULTIPLE AAV VECTORS

TORNABENE, PATRIZIA · 2019 · Università degli Studi di Milano (AIR) · DOI

Full title: LARGE GENE DELIVERY TO THE RETINA BY MULTIPLE AAV VECTORS

Authors: TORNABENE, PATRIZIA

Year: 2019

Venue: Università degli Studi di Milano (AIR)

DOI: http://hdl.handle.net/2434/608611

Thesis Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Murayyan, Abdulmonem · 2013 · University of Guelph · DOI

Full title: Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Authors: Murayyan, Abdulmonem

Year: 2013

Venue: University of Guelph

DOI: http://hdl.handle.net/10214/6604

Thesis Bioprocess Engineering for HIV-1 Gag VLP Production in HEK293 Cells

Lavado García, Jesús · 2022 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Bioprocess Engineering for HIV-1 Gag VLP Production in HEK293 Cells

Authors: Lavado García, Jesús

Year: 2022

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/674392

Thesis Development and optimization of the attB system to produce Helper-dependent Adenovirus vectors of different species

Cots i Rabella, Dan · 2014 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Development and optimization of the attB system to produce Helper-dependent Adenovirus vectors of different species

Authors: Cots i Rabella, Dan

Year: 2014

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/283431

Thesis One for all, all for one: Combining and improving AAV, RNAi and CRISPR technologies to combat HBV infection and HBV/HDV co-infections

Schmelas, Carolin · 2020 · Heidelberg University · DOI

Full title: One for all, all for one: Combining and improving AAV, RNAi and CRISPR technologies to combat HBV infection and HBV/HDV co-infections

Authors: Schmelas, Carolin

Year: 2020

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/28513/1/Schmelas_Dissertation.pdf

Thesis With small viruses come giant responsibilities - Next-generation parvoviral vectors for human gene therapy with extended packaging capacity and enhanced safety profile

Fakhiri, Julia · 2019 · Heidelberg University · DOI

Full title: With small viruses come giant responsibilities - Next-generation parvoviral vectors for human gene therapy with extended packaging capacity and enhanced safety profile

Authors: Fakhiri, Julia

Year: 2019

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/27326/1/PhD%20thesis%20Julia%20Fakhiri.pdf

Thesis Transient transfection of serum-free suspension HEK 293 cell culture for efficient production of human rFVIII

Covas, Dimas Tadeu · 2011 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Transient transfection of serum-free suspension HEK 293 cell culture for efficient production of human rFVIII

Authors: Covas, Dimas Tadeu

Year: 2011

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.1186/1472-6750-11-114

Thesis Optimalizace rekombinantní exprese proteinů v HEK293 buněčné linii

Bláha, Jan · 2017 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Optimalizace rekombinantní exprese proteinů v HEK293 buněčné linii

Authors: Bláha, Jan

Year: 2017

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/29866

Thesis Adeno-associated virus (AAV) transduction of primary human CD4+T lymphocytes

Kamel, Sahar Hussein · 2014 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Adeno-associated virus (AAV) transduction of primary human CD4+T lymphocytes

Authors: Kamel, Sahar Hussein

Year: 2014

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=wright1409957026

Thesis A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing

Woodruff, Kristina; Maerkl, Sebastian J. · 2016 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing

Authors: Woodruff, Kristina; Maerkl, Sebastian J.

Year: 2016

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/127380

Thesis Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses

Fakhiri, Julia; Schneider, Marc A.; Puschhof, Jens et al. · 2019 · Utrecht University · DOI

Full title: Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses

Authors: Fakhiri, Julia; Schneider, Marc A.; Puschhof, Jens; Stanifer, Megan; Schildgen, Verena; Holderbach, Stefan; Voss, Yannik; El Andari, Jihad; Schildgen, Oliver; Boulant, Steeve; Meister, Michael; Clevers, Hans; Yan, Ziying; Qiu, Jianming; Grimm, Dirk

Year: 2019

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/439383

Thesis Development of an Improved Transient Triple Transfection System with Focus on Engineering the Helper Plasmid for Enhanced rAAV Production

Pohle, Thilo · 2023 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Development of an Improved Transient Triple Transfection System with Focus on Engineering the Helper Plasmid for Enhanced rAAV Production

Authors: Pohle, Thilo

Year: 2023

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/35606/1/PhDThesis_THP_final.pdf

Thesis Herstellung optimierter Sf9-Zelllinien für die Baculovirus-basierte Produktion rekombinanter AAV5-Vektoren mit hoher Infektiosität

Casteleyn, Vincent · 2022 · Freie Universität Berlin (Refubium) · DOI

Full title: Herstellung optimierter Sf9-Zelllinien für die Baculovirus-basierte Produktion rekombinanter AAV5-Vektoren mit hoher Infektiosität

Authors: Casteleyn, Vincent

Year: 2022

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/33543

Thesis CELL ENGINEERING AND CULTURE MEDIA MODIFICATION STUDIES TO IMPROVE THE CELL CULTURE PERFORMANCE

Dhara, Venkata Gayatri · 2019 · Johns Hopkins University · DOI

Full title: CELL ENGINEERING AND CULTURE MEDIA MODIFICATION STUDIES TO IMPROVE THE CELL CULTURE PERFORMANCE

Authors: Dhara, Venkata Gayatri

Year: 2019

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/60428

Thesis Preparation and functionalization of magnetic iron oxide nanoparticles for application in gene delivery

Arsianti, Maria · 2010 · UNSW Sydney · DOI

Full title: Preparation and functionalization of magnetic iron oxide nanoparticles for application in gene delivery

Authors: Arsianti, Maria

Year: 2010

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/50261

Thesis Development of new strategies for efficient production and purification of recombinant adeno-associated virus (rAAV) vector /

Liu, Xingluo · 1999 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Development of new strategies for efficient production and purification of recombinant adeno-associated virus (rAAV) vector /

Authors: Liu, Xingluo

Year: 1999

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1488187049541563

Thesis Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Blessing, Daniel; Vachey, Gabriel; Pythoud, Catherine et al. · 2019 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Authors: Blessing, Daniel; Vachey, Gabriel; Pythoud, Catherine; Rey, Maria; Padrun, Vivianne; Wurm, Florian M.; Schneider, Bernard L.; Deglon, Nicole

Year: 2019

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/158621

Thesis Transient recombinant protein expression in mammalian cells : the role of mRNA level and stability

Wulhfard, Sarah · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transient recombinant protein expression in mammalian cells : the role of mRNA level and stability

Authors: Wulhfard, Sarah

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/36998

Thesis Recombinant protein production by large-scale transient gene expression in mammalian cells : state of the art and future perspectives

Baldi, L; Hacker, DL; Adam, M et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Recombinant protein production by large-scale transient gene expression in mammalian cells : state of the art and future perspectives

Authors: Baldi, L; Hacker, DL; Adam, M; Wurm, FM

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/8764

Thesis Production de vecteurs viraux efficaces pour la transduction de cellules transformées et de cellules primaires

Pilotte, Amélie · 2016 · Université de Montréal (Papyrus) · DOI

Full title: Production de vecteurs viraux efficaces pour la transduction de cellules transformées et de cellules primaires

Authors: Pilotte, Amélie

Year: 2016

Venue: Université de Montréal (Papyrus)

DOI: http://hdl.handle.net/1866/15572

Thesis Optimisation and Application of Nanoelectroporation for Clonal β-Cell Transfection

Ekstrand, Frida · 2025 · Lund University (LUP) · DOI

Full title: Optimisation and Application of Nanoelectroporation for Clonal β-Cell Transfection

Authors: Ekstrand, Frida

Year: 2025

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/097ab391-be95-4cc3-b370-b1ea33b8a03d

Thesis Geração de clones de células HEK293 superprodutores de isoformas recombinantes de VEGF-A (Fator de Crescimento Endotelial Vascular A) humano visando à produção de biofármacos para terapia molecular e engenharia tecidual

Sogayar, Mari Cleide · 2014 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Geração de clones de células HEK293 superprodutores de isoformas recombinantes de VEGF-A (Fator de Crescimento Endotelial Vascular A) humano visando à produção de biofármacos para terapia molecular e engenharia tecidual

Authors: Sogayar, Mari Cleide

Year: 2014

Venue: Universidade de São Paulo – USP Digital Library

DOI: http://www.teses.usp.br/teses/disponiveis/46/46131/tde-01102014-145602/

Thesis Retroviral transduction of hematopoietic stem cells : optimisation of parameters for transduction

Wotherspoon, Simon Lance · 2005 · UNSW Sydney · DOI

Full title: Retroviral transduction of hematopoietic stem cells : optimisation of parameters for transduction

Authors: Wotherspoon, Simon Lance

Year: 2005

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/66240

Thesis Targeted lentiviral vectors pseudotyped with the Tupaia paramyxovirus glycoproteins

Enkirch, Theresa · 2011 · Heidelberg University · DOI

Full title: Targeted lentiviral vectors pseudotyped with the Tupaia paramyxovirus glycoproteins

Authors: Enkirch, Theresa

Year: 2011

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/12946/1/DrArbeit_FINAL_Theresa.pdf

Thesis Lipid nanoparticle-mediated messenger RNA delivery for ex vivo engineering of natural killer cells

Douka, Stefania; Brandenburg, Lisa E; Casadidio, Cristina et al. · 2023 · Utrecht University · DOI

Full title: Lipid nanoparticle-mediated messenger RNA delivery for ex vivo engineering of natural killer cells

Authors: Douka, Stefania; Brandenburg, Lisa E; Casadidio, Cristina; Walther, Johanna; Garcia, Bianca Bonetto Moreno; Spanholtz, Jan; Raimo, Monica; Hennink, Wim E; Mastrobattista, Enrico; Caiazzo, Massimiliano

Year: 2023

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/432851

Thesis Vývoj techniky pro transfer genů do T-lymfocytů pomocí polyomavirových struktur a peptidu LAH4

Schreiberová, Lucie · 2020 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Vývoj techniky pro transfer genů do T-lymfocytů pomocí polyomavirových struktur a peptidu LAH4

Authors: Schreiberová, Lucie

Year: 2020

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/122022

Thesis Strategies for improving production levels of HIV-1 VLPs by transient transfection of HEK 293 suspension cultures

Cervera Garcia, Laura · 2015 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Strategies for improving production levels of HIV-1 VLPs by transient transfection of HEK 293 suspension cultures

Authors: Cervera Garcia, Laura

Year: 2015

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/289626

Thesis Scalable Production of Genome-Edited Livestock Embryos

Lin, Jason Chen · 2022 · University of California, Davis · DOI

Full title: Scalable Production of Genome-Edited Livestock Embryos

Authors: Lin, Jason Chen

Year: 2022

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/8hs7x39z

Thesis Characterisation of cellular responses and gene delivery capabilities within porous agarose scaffolds

Sullivan, Matthew Scott · 2024 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Characterisation of cellular responses and gene delivery capabilities within porous agarose scaffolds

Authors: Sullivan, Matthew Scott

Year: 2024

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/35132/1/M%20S%20Sullivan%202024.pdf

Thesis Optimising adeno associated virus mediated gene therapy

Mallik, Shreyashee · 2023 · University of Sydney · DOI

Full title: Optimising adeno associated virus mediated gene therapy

Authors: Mallik, Shreyashee

Year: 2023

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/31477

Thesis Factors affecting AAV production: Mutagenesis of AAV2 rep and AAV transgenes

Jain, Nina Kumari · 2024 · Harvard University - DASH · DOI

Full title: Factors affecting AAV production: Mutagenesis of AAV2 rep and AAV transgenes

Authors: Jain, Nina Kumari

Year: 2024

Venue: Harvard University - DASH

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37377871

Thesis Alternative Produktion rekombinanter Adeno-assoziierter Viren für die Gentherapie

Kuhrs, Annette · 2006 · Freie Universität Berlin (Refubium) · DOI

Full title: Alternative Produktion rekombinanter Adeno-assoziierter Viren für die Gentherapie

Authors: Kuhrs, Annette

Year: 2006

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/12369

Thesis High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells

Hildinger, Markus; Baldi, Lucia; Stettler, Matthieu et al. · 2019 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells

Authors: Hildinger, Markus; Baldi, Lucia; Stettler, Matthieu; Wurm, Florian M.

Year: 2019

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/160357

Thesis Genome engineering in vivo for modeling of human diseases enhanced by AVV technology

Nickl, Petr · 2025 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Genome engineering in vivo for modeling of human diseases enhanced by AVV technology

Authors: Nickl, Petr

Year: 2025

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/196257

Thesis The kinetics of polyethylenimine-mediated transfection in suspension cultures of Chinese hamster ovary cells

Bertschinger, Martin; Schertenleib, Arnaud; Cevey, Jean et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: The kinetics of polyethylenimine-mediated transfection in suspension cultures of Chinese hamster ovary cells

Authors: Bertschinger, Martin; Schertenleib, Arnaud; Cevey, Jean; Hacker, David L.; Wurm, Florian M.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/58359

Thesis Epi-CHO, an episomal expression system for recombinant protein production in CHO cells

Kunaparaju, Raj Kumar · 2008 · UNSW Sydney · DOI

Full title: Epi-CHO, an episomal expression system for recombinant protein production in CHO cells

Authors: Kunaparaju, Raj Kumar

Year: 2008

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/41499

Thesis Systems Engineering for Viral Vector Manufacturing

Nguyen, Tam Ngoc Thanh · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Systems Engineering for Viral Vector Manufacturing

Authors: Nguyen, Tam Ngoc Thanh

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/150243

Thesis Optimalizace expresního systému HEK293 buněčné linie pomocí regulace buněčného cyklu a apoptózy

Poláchová, Edita · 2017 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Optimalizace expresního systému HEK293 buněčné linie pomocí regulace buněčného cyklu a apoptózy

Authors: Poláchová, Edita

Year: 2017

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/68567

Thesis Weighing the DNA Content of Adeno-Associated Virus Vectors with Zeptogram Precision Using Nanomechanical Resonators

Katsikis, Georgios; Hwang, Iris E; Wang, Wade et al. · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Weighing the DNA Content of Adeno-Associated Virus Vectors with Zeptogram Precision Using Nanomechanical Resonators

Authors: Katsikis, Georgios; Hwang, Iris E; Wang, Wade; Bhat, Vikas S; McIntosh, Nicole L; Karim, Omair A; Blus, Bartlomiej J; Sha, Sha; Agache, Vincent; Wolfrum, Jacqueline M; Springs, Stacy L; Sinskey, Anthony J; Barone, Paul W; Braatz, Richard D; Manalis, Scott R

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/146983

Thesis AAV capsid bioengineering in primary human retina models

Westhaus, A; Eamegdool, SS; Fernando, M et al. · 2024 · University of Melbourne · DOI

Full title: AAV capsid bioengineering in primary human retina models

Authors: Westhaus, A; Eamegdool, SS; Fernando, M; Fuller-Carter, P; Brunet, AA; Miller, AL; Rashwan, R; Knight, M; Daniszewski, M; Lidgerwood, GE; Pébay, A; Hewitt, A; Santilli, G; Thrasher, AJ; Carvalho, LS; Gonzalez-Cordero, A; Jamieson, RV; Lisowski, L

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/344430

Thesis Multidose transient transfection of human embryonic kidney 293 cells modulates recombinant adeno‐associated virus2/5 Rep protein expression and influences the enrichment fraction of filled capsids

Srinivasan, Prasanna; Canova, Christopher T; Sha, Sha et al. · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Multidose transient transfection of human embryonic kidney 293 cells modulates recombinant adeno‐associated virus2/5 Rep protein expression and influences the enrichment fraction of filled capsids

Authors: Srinivasan, Prasanna; Canova, Christopher T; Sha, Sha; Nguyen, Tam NT; Joseph, John; Sangerman, Jose; Maloney, Andrew J; Katsikis, Georgios; Ou, Rui Wen; Hong, Moo Sun; Ng, Jaclyn; Yuan, Arella; Antov, Daniel; Song, Sally; Chen, Wenyu; Neufeld, Caleb; Wolfrum, Jacqueline M; Barone, Paul W; Sinskey, Anthony J; Springs, Stacy L; Braatz, Richard D

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/157695

Thesis Analysis of Infection Relevant Protein Domains of the Adeno-Associated Virus Serotype 8 in Comparison to Serotype 2

Raupp, Christina · 2010 · Heidelberg University · DOI

Full title: Analysis of Infection Relevant Protein Domains of the Adeno-Associated Virus Serotype 8 in Comparison to Serotype 2

Authors: Raupp, Christina

Year: 2010

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/10925/1/complete_CRAUPPdiss.pdf

Thesis The design, development and characterization of a self-replicating DNA expression technology

de Moor, Warren Ralph Josephus · 2022 · University of Cape Town · DOI

Full title: The design, development and characterization of a self-replicating DNA expression technology

Authors: de Moor, Warren Ralph Josephus

Year: 2022

Venue: University of Cape Town

DOI: http://hdl.handle.net/11427/36847

Thesis Production and pharmaceutical formulation of plasmid DNA vaccines

van der Heijden, I. · 2013 · Utrecht University · DOI

Full title: Production and pharmaceutical formulation of plasmid DNA vaccines

Authors: van der Heijden, I.

Year: 2013

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/283165

Thesis The effect of cell penetrating peptides on transfection activity and cytotoxicity of polyallylamine

Sabouri-Rad, S; Oskuee, RK; Mahmoodi, A et al. · 2021 · University of Melbourne · DOI

Full title: The effect of cell penetrating peptides on transfection activity and cytotoxicity of polyallylamine

Authors: Sabouri-Rad, S; Oskuee, RK; Mahmoodi, A; Gholami, L; Malaekeh-Nikouei, B

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/277463

Thesis Study of transposon-mediated cell pool and cell line generation in CHO cells

Balasubramanian, Sowmya · 2015 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Study of transposon-mediated cell pool and cell line generation in CHO cells

Authors: Balasubramanian, Sowmya

Year: 2015

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/113896

Thesis Correcting CPS1 Deficiency in Primary Human Hepatocytes In Vivo Using AAV Delivered Cell-Cycle Independent Targeted Genome Editing

Christina, Sharntie · 2024 · University of Sydney · DOI

Full title: Correcting CPS1 Deficiency in Primary Human Hepatocytes In Vivo Using AAV Delivered Cell-Cycle Independent Targeted Genome Editing

Authors: Christina, Sharntie

Year: 2024

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/32857

Thesis Study and characterisation of human HEK293 cell line as a platform for recombinant protein production

Liste Calleja, Leticia · 2015 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Study and characterisation of human HEK293 cell line as a platform for recombinant protein production

Authors: Liste Calleja, Leticia

Year: 2015

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/308324

Thesis Development of an efficient, non-viral transfection method for studying gene function and bone growth in human primary cranial suture mesenchymal cells reveals that the cells respond to BMP2 and BMP3

Dwivedi, PP; Anderson, PJ; Powell, BC · 2022 · University of Melbourne · DOI

Full title: Development of an efficient, non-viral transfection method for studying gene function and bone growth in human primary cranial suture mesenchymal cells reveals that the cells respond to BMP2 and BMP3

Authors: Dwivedi, PP; Anderson, PJ; Powell, BC

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/304511

Thesis Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Cosenza, Zachary Anthony · 2022 · University of California, Davis · DOI

Full title: Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Authors: Cosenza, Zachary Anthony

Year: 2022

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/119489fc

Thesis Producing and Concentrating Lenti-Cre for Mouse Infections

Gierut, J. J.; Haigis, K. M.; Jacks, Tyler E. · 2018 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Producing and Concentrating Lenti-Cre for Mouse Infections

Authors: Gierut, J. J.; Haigis, K. M.; Jacks, Tyler E.

Year: 2018

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/116575

Thesis Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions

Backliwal, G; Hildinger, M; Chenuet, S et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions

Authors: Backliwal, G; Hildinger, M; Chenuet, S; Wulhfard, S; De Jesus, M; Wurm, FM

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41410

Thesis Comparison of CRISPR/Cas Endonucleases for in vivo Retinal Gene Editing

Li, F; Wing, K; Wang, JH et al. · 2020 · University of Melbourne · DOI

Full title: Comparison of CRISPR/Cas Endonucleases for in vivo Retinal Gene Editing

Authors: Li, F; Wing, K; Wang, JH; Luu, CD; Bender, JA; Chen, J; Wang, Q; Lu, Q; Nguyen Tran, MT; Young, KM; Wong, RCB; Pébay, A; Cook, AL; Hung, SSC; Liu, GS; Hewitt, AW

Year: 2020

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/251585

Thesis Adeno-Associated Virus Vectors for Gene Therapy

Mietzsch, Mario · 2014 · Freie Universität Berlin (Refubium) · DOI

Full title: Adeno-Associated Virus Vectors for Gene Therapy

Authors: Mietzsch, Mario

Year: 2014

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/6047

Thesis Improving the immunogenicity of recombinant adeno-associated virus

Ussher, James Edgeworth · 2010 · University of Auckland · DOI

Full title: Improving the immunogenicity of recombinant adeno-associated virus

Authors: Ussher, James Edgeworth

Year: 2010

Venue: University of Auckland

DOI: https://hdl.handle.net/2292/6030

Thesis Optimizing an Adeno-Associated Virus Vector System for Monogenic Diseases: Promoter Discovery and In Vivo Dosing Insights from a Neonatal Pig Model

Zielinska, Nicole · 2025 · University of Guelph · DOI

Full title: Optimizing an Adeno-Associated Virus Vector System for Monogenic Diseases: Promoter Discovery and In Vivo Dosing Insights from a Neonatal Pig Model

Authors: Zielinska, Nicole

Year: 2025

Venue: University of Guelph

DOI: https://hdl.handle.net/10214/29254

Thesis Optmierung des Gentransfers in humane Keratinozyten mittels rekombinanter Adeno-assoziierter Virus Vektoren

Eisenried, Angelika · 2007 · Technical University of Munich · DOI

Full title: Optmierung des Gentransfers in humane Keratinozyten mittels rekombinanter Adeno-assoziierter Virus Vektoren

Authors: Eisenried, Angelika

Year: 2007

Venue: Technical University of Munich

DOI: https://mediatum.ub.tum.de/620611

Thesis Identification and Validation of Target Receptors/Transporters for AAV9

Roach, Matthew · 2023 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Identification and Validation of Target Receptors/Transporters for AAV9

Authors: Roach, Matthew

Year: 2023

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/33782/1/MatthewRoach_PhD_Thesis_with_corrections_MR%20edit.pdf

Thesis Genetic Modification of Adeno-Associated Virus Capsid for Enhanced Motor Neuron Delivery and Retrograde Transport

Davis, Adam Scott · 2012 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Genetic Modification of Adeno-Associated Virus Capsid for Enhanced Motor Neuron Delivery and Retrograde Transport

Authors: Davis, Adam Scott

Year: 2012

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1351693788

Thesis A study of apoptosis and cell cycle to augment transfection efficiency in CHO cell lines

Wanandy, Nico Stanislaus · 2007 · UNSW Sydney · DOI

Full title: A study of apoptosis and cell cycle to augment transfection efficiency in CHO cell lines

Authors: Wanandy, Nico Stanislaus

Year: 2007

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/40868

Thesis Expressão gênica empregando pseudopartículas em células de mamíferos (HEK 293T e Huh 7.0) cultivadas em diferentes meios de cultura livres de soro

Jorge, Soraia Attie Calil · 2016 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Expressão gênica empregando pseudopartículas em células de mamíferos (HEK 293T e Huh 7.0) cultivadas em diferentes meios de cultura livres de soro

Authors: Jorge, Soraia Attie Calil

Year: 2016

Venue: Universidade de São Paulo – USP Digital Library

DOI: http://www.teses.usp.br/teses/disponiveis/87/87131/tde-24082016-113658/

Thesis Adeno-associated virus rep78 expression in Arabidopsis thaliana

Sisco, Daniel · 2011 · Virginia Tech - VTechWorks · DOI

Full title: Adeno-associated virus rep78 expression in Arabidopsis thaliana

Authors: Sisco, Daniel

Year: 2011

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/9706

Thesis Evaluation of safety and methods for production of retroviral vectors for use in gene therapy

Kewney, Caroline · 1998 · University of Glasgow · DOI

Full title: Evaluation of safety and methods for production of retroviral vectors for use in gene therapy

Authors: Kewney, Caroline

Year: 1998

Venue: University of Glasgow

DOI: https://theses.gla.ac.uk/71502/7/10391130.pdf

Thesis Adeno-Associated Virus Gene Therapy For Maple Syrup Urine Disease

Mullany, Kathryn Louise · 2025 · University of Sydney · DOI

Full title: Adeno-Associated Virus Gene Therapy For Maple Syrup Urine Disease

Authors: Mullany, Kathryn Louise

Year: 2025

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/34263

Thesis Enhancement of virus-like particle production in HEK293 cell cultures

Fuenmayor Garcés, Javier · 2018 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Enhancement of virus-like particle production in HEK293 cell cultures

Authors: Fuenmayor Garcés, Javier

Year: 2018

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/650410

Thesis Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76323

Thesis Charakterisierung eines parvoviralen Hybridvektors hinsichtlich der Transduktion und präferentiellen Expression in transformierten Zellen

Krüger, Lars · 2005 · Heidelberg University · DOI

Full title: Charakterisierung eines parvoviralen Hybridvektors hinsichtlich der Transduktion und präferentiellen Expression in transformierten Zellen

Authors: Krüger, Lars

Year: 2005

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/5635/1/Dissertation_LK.pdf

Thesis Untersuchungen zum Gentransfer in die Lunge mittels nicht-viraler Pulveraerosole und viraler Vektoren basierend auf dem Adeno-assoziierten Virus (AAV) 2/9

Pfeifer, Corinna · 2011 · Freie Universität Berlin (Refubium) · DOI

Full title: Untersuchungen zum Gentransfer in die Lunge mittels nicht-viraler Pulveraerosole und viraler Vektoren basierend auf dem Adeno-assoziierten Virus (AAV) 2/9

Authors: Pfeifer, Corinna

Year: 2011

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/6992

Thesis Identifizierung und Optimierung kritischer Schritte bei der Transfektion eukaryontischer Zellen

Schurig, Michael · 2009 · Technical University of Munich · DOI

Full title: Identifizierung und Optimierung kritischer Schritte bei der Transfektion eukaryontischer Zellen

Authors: Schurig, Michael

Year: 2009

Venue: Technical University of Munich

DOI: https://mediatum.ub.tum.de/667447

Thesis Efficiency of transgene expression in bovine cells varies according to cell type and gene transfer method

Dias, Angelo José Burla · 2019 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Efficiency of transgene expression in bovine cells varies according to cell type and gene transfer method

Authors: Dias, Angelo José Burla

Year: 2019

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.17533/udea.rccp.v32n1a04

Thesis Production of AAV vectors for gene therapy : a cost-effectiveness and risk assessment

Rodríguez Pinhao Miessner, Diego · 2016 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Production of AAV vectors for gene therapy : a cost-effectiveness and risk assessment

Authors: Rodríguez Pinhao Miessner, Diego

Year: 2016

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/104215

Thesis Correlation between cell cycle and calcium phosphate transient transfection of CHO cells

Grosjean, Frédéric · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Correlation between cell cycle and calcium phosphate transient transfection of CHO cells

Authors: Grosjean, Frédéric

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/211990

Thesis Produção de vetores lentivirais baseados em HIV-1 em linhagem de célula tronco mesenquimal murina

Silva, Flávia Helena da · 2007 · Universidade Federal do Rio Grande do Sul – LUME · DOI

Full title: Produção de vetores lentivirais baseados em HIV-1 em linhagem de célula tronco mesenquimal murina

Authors: Silva, Flávia Helena da

Year: 2007

Venue: Universidade Federal do Rio Grande do Sul – LUME

DOI: http://hdl.handle.net/10183/8134

Thesis Design of a Novel Gene Therapy Construct to Achieve Sustained Brain-Derived Neurotrophic Factor Signaling in Neurons.

Osborne, Andrew; Wang, Aiden XZ; Tassoni, Alessia et al. · 2018 · University of Cambridge · DOI

Full title: Design of a Novel Gene Therapy Construct to Achieve Sustained Brain-Derived Neurotrophic Factor Signaling in Neurons.

Authors: Osborne, Andrew; Wang, Aiden XZ; Tassoni, Alessia; Widdowson, Peter S; Martin, Keith R

Year: 2018

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/274008

Thesis Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

Muller, N.; Derouazi, M.; Van Tilborgh, F. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

Authors: Muller, N.; Derouazi, M.; Van Tilborgh, F.; Wulhfard, S.; Hacker, D. L.; Jordan, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9754

Thesis Generation of recombinant Chinese hamster ovary cell lines by microinjection

Derouazi, M.; Flaction, R.; Girard, P. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Generation of recombinant Chinese hamster ovary cell lines by microinjection

Authors: Derouazi, M.; Flaction, R.; Girard, P.; de Jesus, M.; Jordan, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7686

Thesis Quantitative analysis of non-viral gene therapy in primary liver culture systems

Tedford, Nathan C · 2008 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Quantitative analysis of non-viral gene therapy in primary liver culture systems

Authors: Tedford, Nathan C

Year: 2008

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/39914

Thesis Développement de procédés efficaces pour la construction et la production de vecteurs adénoviraux

Gagnon, David · 2010 · Université de Montréal (Papyrus) · DOI

Full title: Développement de procédés efficaces pour la construction et la production de vecteurs adénoviraux

Authors: Gagnon, David

Year: 2010

Venue: Université de Montréal (Papyrus)

DOI: http://hdl.handle.net/1866/4462

Thesis Impact of Formulation Conditions on Lipid Nanoparticle Characteristics and Functional Delivery of CRISPR RNP for Gene Knock-Out and Correction

Walther, Johanna; Wilbie, Danny; Tissingh, Vincent S.J. et al. · 2022 · Utrecht University · DOI

Full title: Impact of Formulation Conditions on Lipid Nanoparticle Characteristics and Functional Delivery of CRISPR RNP for Gene Knock-Out and Correction

Authors: Walther, Johanna; Wilbie, Danny; Tissingh, Vincent S.J.; Öktem, Mert; Van Der Veen, Heleen; Lou, Bo; Mastrobattista, Enrico

Year: 2022

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/422276

Thesis Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency

Sork, Helena; Nordin, Joel Z; Turunen, Janne J et al. · 2016 · Utrecht University · DOI

Full title: Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency

Authors: Sork, Helena; Nordin, Joel Z; Turunen, Janne J; Wiklander, Oscar Pb; Bestas, Burcu; Zaghloul, Eman M; Margus, Helerin; Padari, Kärt; Duru, Adil D; Corso, Giulia; Bost, Jeremy; Vader, Pieter; Pooga, Margus; Smith, Ci Edvard; Wood, Matthew Ja; Schiffelers, Raymond M; Hällbrink, Mattias; Andaloussi, Samir El

Year: 2016

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/336850

Thesis DEAE-Dextran Enhances the Lentiviral Transduction of Primary Human Mesenchymal Stromal Cells from All Major Tissue Sources Without Affecting Their Proliferation and Phenotype

Amadeo, Francesco; Hanson, Vivien; Murray, Patricia et al. · 2023 · University of Liverpool · DOI

Full title: DEAE-Dextran Enhances the Lentiviral Transduction of Primary Human Mesenchymal Stromal Cells from All Major Tissue Sources Without Affecting Their Proliferation and Phenotype

Authors: Amadeo, Francesco; Hanson, Vivien; Murray, Patricia; Taylor, Arthur

Year: 2023

Venue: University of Liverpool

DOI: https://livrepository.liverpool.ac.uk/3162174/1/library.pdf

Thesis RECOMBINANT AAV6 GENE THERAPY VECTORS: PROCESS OPTIMIZATION AND SCALE UP INTO THE iCELLis NANO BIOREACTOR

Borges, Gwynneth · 2021 · Johns Hopkins University · DOI

Full title: RECOMBINANT AAV6 GENE THERAPY VECTORS: PROCESS OPTIMIZATION AND SCALE UP INTO THE iCELLis NANO BIOREACTOR

Authors: Borges, Gwynneth

Year: 2021

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/63567

Thesis Transient transfection induces different intracellular calcium signaling in CHO K1 versus HEK 293 cells

Preuss, A. K.; Connor, J. A.; Vogel, H. · 2019 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transient transfection induces different intracellular calcium signaling in CHO K1 versus HEK 293 cells

Authors: Preuss, A. K.; Connor, J. A.; Vogel, H.

Year: 2019

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/160503

Thesis Možné přístupy k terapii cystické fibrosy

Král, Jan · 2019 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Možné přístupy k terapii cystické fibrosy

Authors: Král, Jan

Year: 2019

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/97888

Thesis A Mechanistic Dissection of Polyethylenimine Mediated Transfection of Chinese Hamster Ovary Cells

Mozley, O L · 2013 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: A Mechanistic Dissection of Polyethylenimine Mediated Transfection of Chinese Hamster Ovary Cells

Authors: Mozley, O L

Year: 2013

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/5593/1/A%20mechanistic%20dissection%20of%20polyethylenimine%20mediated%20transfection%20of%20chinese%20hamster%20ovary%20cells.pdf

Thesis Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel et al. · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Authors: Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel; Dang, Brendan; Wolffe, Lenna A; Atari, Adel; Tseng, Yuen-Yi; Love, J Christopher

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/163220

Thesis Gene modification and biotechnological applications of mesenchymal stem cells

Bosch, Pablo · 2024 · University of Georgia - UGA Open Scholar · DOI

Full title: Gene modification and biotechnological applications of mesenchymal stem cells

Authors: Bosch, Pablo

Year: 2024

Venue: University of Georgia - UGA Open Scholar

DOI: https://openscholar.uga.edu/record/20238/files/bosch_pablo_200508_phd.pdf

Thesis Use of Transient Transfection for cGMP Manufacturing of eOD-GT8 60mer, a Self-Assembling Nanoparticle Germline-Targeting HIV-1 Vaccine Candidate

Sharma, Vaneet K.; Menis, Sergey; Brower, Evan T. et al. · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Use of Transient Transfection for cGMP Manufacturing of eOD-GT8 60mer, a Self-Assembling Nanoparticle Germline-Targeting HIV-1 Vaccine Candidate

Authors: Sharma, Vaneet K.; Menis, Sergey; Brower, Evan T.; Sayeed, Eddy; Ackland, Jim; Lombardo, Angela; Cottrell, Christopher A.; Torres, Jonathan L.; Hassell, Thomas; Ward, Andrew B.; Tsvetnitsky, Vadim; Schief, William R.

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/155438

Thesis Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse

Kauffman, Kevin John; Oberli, Matthias; Dorkin, Joseph Robert et al. · 2019 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse

Authors: Kauffman, Kevin John; Oberli, Matthias; Dorkin, Joseph Robert; Hurtado, Juan E.; Kaczmarek, James Cliff; Bhadani, Shivani; Wyckoff, Jeffrey; Langer, Robert S; Jaklenec, Ana; Anderson, Daniel Griffith

Year: 2019

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/122015

Thesis Understanding the cell density effect upon transient transfection in HEK293 cell culture during HIV-1 VLP production

Pérez Rubio, Pol · 2024 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Understanding the cell density effect upon transient transfection in HEK293 cell culture during HIV-1 VLP production

Authors: Pérez Rubio, Pol

Year: 2024

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/693156

Thesis Modified cell penetrating peptides for efficient gene transfer in vitro and in vivo

Osman, Gizem · 2017 · University of Nottingham · DOI

Full title: Modified cell penetrating peptides for efficient gene transfer in vitro and in vivo

Authors: Osman, Gizem

Year: 2017

Venue: University of Nottingham

DOI: https://eprints.nottingham.ac.uk/41863/1/00%20MASTER%20-%20G.Osman.pdf

Thesis Transient gene expression for rapid protein production : studies & optimizations under serum-free conditions

Muller, Natalie · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transient gene expression for rapid protein production : studies & optimizations under serum-free conditions

Authors: Muller, Natalie

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/214287

Thesis Structural, Viral, and Host Factors of Adeno-Associated Virus Assembly

Maurer, Anna · 2019 · Harvard University - DASH · DOI

Full title: Structural, Viral, and Host Factors of Adeno-Associated Virus Assembly

Authors: Maurer, Anna

Year: 2019

Venue: Harvard University - DASH

DOI: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42029713

Thesis Desarrollo de procesos de producción de proteínas bioterapéuticas: Aumento de la productividad especifica en células HEK293

Román Roldán, Ramón · 2018 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Desarrollo de procesos de producción de proteínas bioterapéuticas: Aumento de la productividad especifica en células HEK293

Authors: Román Roldán, Ramón

Year: 2018

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/650828

Thesis A novel AAV9 random peptide library to select for endothelial cell – directed gene transfer vectors

Varadi, Karl · 2011 · Heidelberg University · DOI

Full title: A novel AAV9 random peptide library to select for endothelial cell – directed gene transfer vectors

Authors: Varadi, Karl

Year: 2011

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/12542/1/Dissertation_Karl_Varadi.pdf

Thesis Adeno-associated virus capsid assembly is divergent and stochastic

Wörner, Tobias P; Bennett, Antonette; Habka, Sana et al. · 2021 · Utrecht University · DOI

Full title: Adeno-associated virus capsid assembly is divergent and stochastic

Authors: Wörner, Tobias P; Bennett, Antonette; Habka, Sana; Snijder, Joost; Friese, Olga; Powers, Thomas; Agbandje-McKenna, Mavis; Heck, Albert J R

Year: 2021

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/411860

Thesis A comparison of intravenous and indirect intracoronary delivery of AAV5, AAV6 and AAV9 for cardiac gene transfer in mice

Fang, Hongfei · 2011 · University of California, San Diego (UCSD) · DOI

Full title: A comparison of intravenous and indirect intracoronary delivery of AAV5, AAV6 and AAV9 for cardiac gene transfer in mice

Authors: Fang, Hongfei

Year: 2011

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/1024d4fh

Thesis Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Lee, John; Nist-Lund, Carl; Solanes, Paola et al. · 2020 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Authors: Lee, John; Nist-Lund, Carl; Solanes, Paola; Goldberg, Hannah; Wu, Jason; Pan, Bifeng; Schneider, Bernard L.; Holt, Jeffrey R.

Year: 2020

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/171017

Thesis Optimalizace kultivačního média HEK293 buněčné linie

Čuperková, Romana · 2017 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Optimalizace kultivačního média HEK293 buněčné linie

Authors: Čuperková, Romana

Year: 2017

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/45606

Thesis Production of Virus-Like Particles in HEK 293 cells and functionalization with SARS-CoV-2

Boix i Besora, Arnau · 2022 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Production of Virus-Like Particles in HEK 293 cells and functionalization with SARS-CoV-2

Authors: Boix i Besora, Arnau

Year: 2022

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/675518

Thesis A synthetic approach to produce recombinant adeno-associated virus (rAAV) in Chinese hamster ovary (CHO) cells

Cai, Wen · 2024 · University of Minnesota - Digital Conservancy · DOI

Full title: A synthetic approach to produce recombinant adeno-associated virus (rAAV) in Chinese hamster ovary (CHO) cells

Authors: Cai, Wen

Year: 2024

Venue: University of Minnesota - Digital Conservancy

DOI: https://hdl.handle.net/11299/259525

Thesis Novel High-Throughput Methods to Study AAV Immunity Using Combinatorial Capsid Libraries

Schmit, Pauline Frances · 2021 · Harvard University - DASH · DOI

Full title: Novel High-Throughput Methods to Study AAV Immunity Using Combinatorial Capsid Libraries

Authors: Schmit, Pauline Frances

Year: 2021

Venue: Harvard University - DASH

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369455

Thesis Utilização de shRNA anti-hexon, anti-IVa2 e anti-pol durante a produção de vírus adeno-associado como estratégia de eliminar Adenovírus helper:: prova de princípio

Strauss, Bryan Eric · 2016 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Utilização de shRNA anti-hexon, anti-IVa2 e anti-pol durante a produção de vírus adeno-associado como estratégia de eliminar Adenovírus helper:: prova de princípio

Authors: Strauss, Bryan Eric

Year: 2016

Venue: Universidade de São Paulo – USP Digital Library

DOI: http://www.teses.usp.br/teses/disponiveis/5/5155/tde-13032017-101533/

Thesis Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells

Nguyen, Tam N.T.; Sha, Sha; Hong, Moo Sun et al. · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells

Authors: Nguyen, Tam N.T.; Sha, Sha; Hong, Moo Sun; Maloney, Andrew J.; Barone, Paul W.; Neufeld, Caleb; Wolfrum, Jacqueline; Springs, Stacy L.; Sinskey, Anthony J.; Braatz, Richard D.

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/135559.2

Thesis Derivation of rep-positive adeno-associated virus vectors and analysis of site-specific integration /

Philpott, Jessica R. · 2000 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Derivation of rep-positive adeno-associated virus vectors and analysis of site-specific integration /

Authors: Philpott, Jessica R.

Year: 2000

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1488192119261715

Thesis Untersuchung der zellspezifischen In-situ-Effizienz des Nukleinsäuretransfers in das Herzgewebe

Liu, Zihou · 2021 · Freie Universität Berlin (Refubium) · DOI

Full title: Untersuchung der zellspezifischen In-situ-Effizienz des Nukleinsäuretransfers in das Herzgewebe

Authors: Liu, Zihou

Year: 2021

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/31132

Thesis Study of the improved Sf9 transient gene expression process

Shen, Xiao; Hacker, David L.; Baldi, Lucia et al. · 2014 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Study of the improved Sf9 transient gene expression process

Authors: Shen, Xiao; Hacker, David L.; Baldi, Lucia; Wurm, Florian M.

Year: 2014

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/100125

Thesis Non-viral gene delivery with pH-sensitive gemini nanoparticles : synthesis of gemini surfactant building blocks, characterization and in vitro screening of transfection efficiency and toxicity

Donkuru, McDonald · 2009 · University of Saskatchewan - HARVEST · DOI

Full title: Non-viral gene delivery with pH-sensitive gemini nanoparticles : synthesis of gemini surfactant building blocks, characterization and in vitro screening of transfection efficiency and toxicity

Authors: Donkuru, McDonald

Year: 2009

Venue: University of Saskatchewan - HARVEST

DOI: http://hdl.handle.net/10388/etd-01132009-131423

Thesis Enhancing Production of Recombinant Proteins from Mammalian Cells

Wong, Victor V.T.; Wong, Niki S.C.; Tan, Hong-Kiat et al. · 2003 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Enhancing Production of Recombinant Proteins from Mammalian Cells

Authors: Wong, Victor V.T.; Wong, Niki S.C.; Tan, Hong-Kiat; Wang, Daniel I.C.; Yap, Miranda G.S.

Year: 2003

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/3782

Thesis Optimalizace rekombinantní exprese proteinů v lidské buněčné linii HEK293

Murajdová, Viktória · 2024 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Optimalizace rekombinantní exprese proteinů v lidské buněčné linii HEK293

Authors: Murajdová, Viktória

Year: 2024

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/194250

Thesis Quantitative correlation between transcriptional levels of ER chaperone, peroximal protein and FVIII productivity in human Hek-293 cell line

Covas, Dimas Tadeu · 2013 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Quantitative correlation between transcriptional levels of ER chaperone, peroximal protein and FVIII productivity in human Hek-293 cell line

Authors: Covas, Dimas Tadeu

Year: 2013

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.1186/2193-1801-2-328

Thesis Evaluierung von Nukleoprotein-kodierenden AAV Vektoren als breitenwirksame Influenza-Impfstoffe

Fiddeke, Katharina · 2017 · Freie Universität Berlin (Refubium) · DOI

Full title: Evaluierung von Nukleoprotein-kodierenden AAV Vektoren als breitenwirksame Influenza-Impfstoffe

Authors: Fiddeke, Katharina

Year: 2017

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/8958

Thesis Adeno-Associated Virus Vector Development for Monoclonal Antibody Expression to Prevent Ebola Virus Infection

van Lieshout, Laura · 2018 · University of Guelph · DOI

Full title: Adeno-Associated Virus Vector Development for Monoclonal Antibody Expression to Prevent Ebola Virus Infection

Authors: van Lieshout, Laura

Year: 2018

Venue: University of Guelph

DOI: http://hdl.handle.net/10214/14680

Thesis White-Box Approaches to Cell Culture Media Optimization for Cultivated Meat

O'Neill, Edward N · 2024 · University of California, Davis · DOI

Full title: White-Box Approaches to Cell Culture Media Optimization for Cultivated Meat

Authors: O'Neill, Edward N

Year: 2024

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/9920t5d7

Thesis In Vivo Delivery and Therapeutic Applications of Base Editors

Yeh, Ariel (Wei-Hsi) · 2020 · Harvard University - DASH · DOI

Full title: In Vivo Delivery and Therapeutic Applications of Base Editors

Authors: Yeh, Ariel (Wei-Hsi)

Year: 2020

Venue: Harvard University - DASH

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37365751

Thesis Optimisation of Delivery of the Ataxia Telangiectasia Mutated Transgene to HeLa Cells Using Glycosaminoglycan Enhanced Transduction

Siam, Ala'a · 2021 · University of Nottingham · DOI

Full title: Optimisation of Delivery of the Ataxia Telangiectasia Mutated Transgene to HeLa Cells Using Glycosaminoglycan Enhanced Transduction

Authors: Siam, Ala'a

Year: 2021

Venue: University of Nottingham

DOI: https://eprints.nottingham.ac.uk/66891/1/Ala%27a%20Siam%20-%20MRes%20Thesis.pdf

Thesis Advanced Process Development in Gene and Cell Therapies

Ladd, Brian · 2025 · KTH Royal Institute of Technology · DOI

Full title: Advanced Process Development in Gene and Cell Therapies

Authors: Ladd, Brian

Year: 2025

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-360154

Thesis Development of a Novel Dual AAV System for Therapeutic Delivery of BDNF

Cheng, Yuhsiang · 2018 · University of California, San Diego (UCSD) · DOI

Full title: Development of a Novel Dual AAV System for Therapeutic Delivery of BDNF

Authors: Cheng, Yuhsiang

Year: 2018

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/3v16w70m

Thesis Advances in crustacean cell culture

Claydon, Kerry · 2009 · James Cook University · DOI

Full title: Advances in crustacean cell culture

Authors: Claydon, Kerry

Year: 2009

Venue: James Cook University

DOI: https://researchonline.jcu.edu.au/11946/11/JCU_11946_Claydon_2009_thesis.pdf

Thesis Semliki Forest Virus as a Vector: Pros and Cons for Its Use in Biopharmaceuticals Production

Fernández Núñez, Eutimio Gustavo [UNESP]; Calil Jorge, Soraia Attie; Astray, Renato Mancini et al. · 2014 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Semliki Forest Virus as a Vector: Pros and Cons for Its Use in Biopharmaceuticals Production

Authors: Fernández Núñez, Eutimio Gustavo [UNESP]; Calil Jorge, Soraia Attie; Astray, Renato Mancini; Rezende, Alexandre Goncalves de; Vale da Costa, Bruno Labate; Ventini Monteiro, Daniella Cristina; Pereira, Carlos Augusto; Tonso, Aldo

Year: 2014

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1590/S1516-89132013000500018

Thesis Enhanced efficiency of lactosylated poly-L-lysine-mediated gene transfer into cystic fibrosis airway epithelial cells

Vliegenthart, J.F.G.; Knollen, W.J.W.; Schembri, F.M. et al. · 1999 · Utrecht University · DOI

Full title: Enhanced efficiency of lactosylated poly-L-lysine-mediated gene transfer into cystic fibrosis airway epithelial cells

Authors: Vliegenthart, J.F.G.; Knollen, W.J.W.; Schembri, F.M.; Gerwig, G.J.; Glick, M.C.; Scanlin, T.F.

Year: 1999

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/5327

Thesis Perfusion‐Based Production of rAAV via an Intensified Transient Transfection Process

Nguyen, Tam NT; Park, Damdae; Canova, Christopher T et al. · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Perfusion‐Based Production of rAAV via an Intensified Transient Transfection Process

Authors: Nguyen, Tam NT; Park, Damdae; Canova, Christopher T; Sangerman, Jose; Srinivasan, Prasanna; Ou, Rui Wen; Barone, Paul W; Neufeld, Caleb; Wolfrum, Jacqueline M; Springs, Stacy L; Sinskey, Anthony J; Braatz, Richard D

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/162858

Thesis Development of a Lentiviral Vector for High-Yield Production of Synthetic and Recombinant GCase for Gaucher Disease Therapy

Coelho, Ana Carolina; Wiezel, Claudia Emília Vieira; de Campos, Alline Cristina et al. · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Development of a Lentiviral Vector for High-Yield Production of Synthetic and Recombinant GCase for Gaucher Disease Therapy

Authors: Coelho, Ana Carolina; Wiezel, Claudia Emília Vieira; de Campos, Alline Cristina; Figueiredo, Lílian Louise Souza; Suardi, Gabriela Aparecida Marcondes; de Paula Bernardes, Juliana; da Cunha Tirapelli, Daniela Pretti; Faça, Vitor Marcel; Abraham, Kuruvilla Joseph; Carlotti-Júnior, Carlos Gilberto; Siciliano, Velia; Weiss, Ron; Gerson, Stanton; Fontes, Aparecida Maria

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/162371

Thesis Establishment of recombinant mammalian cell lines : new approaches

Derouazi, Madiha · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Establishment of recombinant mammalian cell lines : new approaches

Authors: Derouazi, Madiha

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/212504

Thesis Transduktion av plasmid-komplex genom cellmembran med hjälp av akustofluidisk infångning

Eriksson, John · 2024 · Lund University Student Papers · DOI

Full title: Transduktion av plasmid-komplex genom cellmembran med hjälp av akustofluidisk infångning

Authors: Eriksson, John

Year: 2024

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9162786

Thesis Analysis of the Effects of RAS-MAPK Pathway Modulatory Adeno-associated Viral Vectors

Volz, Avery · 2024 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Analysis of the Effects of RAS-MAPK Pathway Modulatory Adeno-associated Viral Vectors

Authors: Volz, Avery

Year: 2024

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1721145531361946

Thesis Construction and characterization of stable cell lines that generate recombinant adeno-associated virus (rAAV) /

Voulgaropoulou, Frosso · 1996 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Construction and characterization of stable cell lines that generate recombinant adeno-associated virus (rAAV) /

Authors: Voulgaropoulou, Frosso

Year: 1996

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1487942476408687

Thesis The development of viral vectors for targeted gene delivery to atherosclerotic plaques

White, Katie · 2007 · University of Glasgow · DOI

Full title: The development of viral vectors for targeted gene delivery to atherosclerotic plaques

Authors: White, Katie

Year: 2007

Venue: University of Glasgow

DOI: https://theses.gla.ac.uk/30729/1/2007WhitePhD.pdf

Thesis Formulation and delivery of dermal DNA vaccines

van den Berg, J.H. · 2009 · Utrecht University · DOI

Full title: Formulation and delivery of dermal DNA vaccines

Authors: van den Berg, J.H.

Year: 2009

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/36212

Thesis Molecular characterization of the avian adeno-associated virus and its use for the development of a viral vector system

Estevez, Carlos · 2024 · University of Georgia - UGA Open Scholar · DOI

Full title: Molecular characterization of the avian adeno-associated virus and its use for the development of a viral vector system

Authors: Estevez, Carlos

Year: 2024

Venue: University of Georgia - UGA Open Scholar

DOI: https://openscholar.uga.edu/record/9951/files/estevez_carlos_n_200405_phd.pdf

Thesis Evaluating Lung Gene Therapy Viral Vector Platforms using Precision-cut Lung Slices as an ex vivo Model

Stevens, Brenna · 2025 · University of Guelph · DOI

Full title: Evaluating Lung Gene Therapy Viral Vector Platforms using Precision-cut Lung Slices as an ex vivo Model

Authors: Stevens, Brenna

Year: 2025

Venue: University of Guelph

DOI: https://hdl.handle.net/10214/29367

Thesis Novel Extracellular Vesicle Modalities for Delivery of Genome Editor Ribonucleoprotein Complexes

Cabeceiras, Peter Keith · 2022 · Harvard University - DASH · DOI

Full title: Novel Extracellular Vesicle Modalities for Delivery of Genome Editor Ribonucleoprotein Complexes

Authors: Cabeceiras, Peter Keith

Year: 2022

Venue: Harvard University - DASH

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372269

Thesis Conception et évaluation d’un nouveau système de transfection ciblée, basé sur l’utilisation du système E/Kcoil

Louvier, Elodie · 2016 · Université de Montréal (Papyrus) · DOI

Full title: Conception et évaluation d’un nouveau système de transfection ciblée, basé sur l’utilisation du système E/Kcoil

Authors: Louvier, Elodie

Year: 2016

Venue: Université de Montréal (Papyrus)

DOI: http://hdl.handle.net/1866/13031

Thesis Generation of stable suspension producer cell lines for serum-free lentivirus production

Klimpel, M; Terrao, M; Bräuer, M et al. · 2024 · University of Melbourne · DOI

Full title: Generation of stable suspension producer cell lines for serum-free lentivirus production

Authors: Klimpel, M; Terrao, M; Bräuer, M; Dersch, H; Biserni, M; Melo Do Nascimento, L; Schwingal, S; Vogel, JE; Ferlemann, C; Brandt, T; Lal, NI; Bridgeman, K; Petzke, A; McDwyer, E; Lim, JL; Oh, S; Brumatti, G; Garcia Minambres, A; Otte, E; Noll, T; Pirzas, V; Laux, H

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/351064

Thesis Magnetofection Potentiates Gene Delivery to Cultured Endothelial Cells

Krötz, Florian; Sohn, Hae-Young; Gloe, Torsten et al. · 2003 · Technical University of Munich (TUM) · DOI

Full title: Magnetofection Potentiates Gene Delivery to Cultured Endothelial Cells

Authors: Krötz, Florian;Sohn, Hae-Young;Gloe, Torsten;Plank, Christian;Pohl, Ulrich

Year: 2003

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1218851

Thesis Glyco-engineered HEK 293-F cell lines to produce therapeutic glycoproteins with human N-glycosylation and improved pharmacokinetics

Uhler, Rico · 2022 · Heidelberg University · DOI

Full title: Glyco-engineered HEK 293-F cell lines to produce therapeutic glycoproteins with human N-glycosylation and improved pharmacokinetics

Authors: Uhler, Rico

Year: 2022

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/31087/1/PhD%20Thesis%20Rico%20Uhler.pdf

Thesis Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

Zhang, Xiaowei; Garcia, Isabel Fernandez; Baldi, Lucia et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

Authors: Zhang, Xiaowei; Garcia, Isabel Fernandez; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/52051

Thesis Engineering inducible cell lines for recombinant Adeno-Associated Virus production

Lee, Zion · 2021 · University of Minnesota - Digital Conservancy · DOI

Full title: Engineering inducible cell lines for recombinant Adeno-Associated Virus production

Authors: Lee, Zion

Year: 2021

Venue: University of Minnesota - Digital Conservancy

DOI: https://hdl.handle.net/11299/225020

Thesis Serum-free suspension adaptation of HEK-293T cells: basis for large-scale biopharmaceutical production

Mizukami, Amanda · 2021 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Serum-free suspension adaptation of HEK-293T cells: basis for large-scale biopharmaceutical production

Authors: Mizukami, Amanda

Year: 2021

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.1590/1678-4324-2021200817

Thesis Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand

Chua, Gek Kee · 2011 · Massey University · DOI

Full title: Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand

Authors: Chua, Gek Kee

Year: 2011

Venue: Massey University

DOI: http://hdl.handle.net/10179/2832

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Metadata only

Paper Enhancement of chitosan-mediated gene delivery through combination with phiC31 integrase.

Oliveira, Ana Vanessa Vieira, Silva, Gabriela Araújo, Chung, Daniel C · 2015 · Acta biomaterialia · DOI

Full title: Enhancement of chitosan-mediated gene delivery through combination with phiC31 integrase.

Authors: Oliveira, Ana Vanessa Vieira, Silva, Gabriela Araújo, Chung, Daniel C

Year: 2015

Venue: Acta biomaterialia

DOI: https://doi.org/10.1016/j.actbio.2015.01.013

Paper Interplay between Triadin and Calsequestrin in the Pathogenesis of CPVT in the Mouse.

Cacheux, Marine, Fauconnier, Jérémy, Thireau, Jérôme, Osseni, Alexis, Brocard, Jacques, Roux-Buisson, Nathalie, Brocard, Julie, Fauré, Julien, Lacampagne, Alain, Marty, Isabelle · 2020 · Molecular therapy : the journal of the American Society of Gene Therapy · DOI

Full title: Interplay between Triadin and Calsequestrin in the Pathogenesis of CPVT in the Mouse.

Authors: Cacheux, Marine, Fauconnier, Jérémy, Thireau, Jérôme, Osseni, Alexis, Brocard, Jacques, Roux-Buisson, Nathalie, Brocard, Julie, Fauré, Julien, Lacampagne, Alain, Marty, Isabelle

Year: 2020

Venue: Molecular therapy : the journal of the American Society of Gene Therapy

DOI: https://doi.org/10.1016/j.ymthe.2019.09.012

Paper Transfection of mammalian cells using linear polyethylenimine is a simple and effective means of producing recombinant adeno-associated virus vectors.

Reed, Sharon E, Staley, Elizabeth M, Mayginnes, John P, Pintel, David J, Tullis, Gregory E · 2006 · Journal of virological methods · DOI

Full title: Transfection of mammalian cells using linear polyethylenimine is a simple and effective means of producing recombinant adeno-associated virus vectors.

Authors: Reed, Sharon E, Staley, Elizabeth M, Mayginnes, John P, Pintel, David J, Tullis, Gregory E

Year: 2006

Venue: Journal of virological methods

DOI: https://doi.org/10.1016/j.jviromet.2006.07.024

Paper Production of an Oncolytic Adeno-Associated Virus Containing the Pro-Apoptotic TRAIL Gene Can Be Improved by shRNA Interference

Donohue, Nicholas, Li, Simeng, Boi, Stefano, Rainbow-Fletcher, Alana, Barron, Niall · 2025 · International Journal of Molecular Sciences · DOI

Full title: Production of an Oncolytic Adeno-Associated Virus Containing the Pro-Apoptotic TRAIL Gene Can Be Improved by shRNA Interference

Authors: Donohue, Nicholas, Li, Simeng, Boi, Stefano, Rainbow-Fletcher, Alana, Barron, Niall

Year: 2025

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms26020567

Paper Advancements in molecular design and bioprocessing of recombinant adeno‐associated virus gene delivery vectors using the insect‐cell baculovirus expression platform

Joshi, Pranav R.H., Venereo-Sánchez, Alina, Chahal, Parminder S., Kamen, Amine · 2020 · Biotechnology Journal · DOI

Full title: Advancements in molecular design and bioprocessing of recombinant adeno‐associated virus gene delivery vectors using the insect‐cell baculovirus expression platform

Authors: Joshi, Pranav R.H., Venereo-Sánchez, Alina, Chahal, Parminder S., Kamen, Amine

Year: 2020

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202000021

Paper Viral gene transfer to developing mouse salivary glands.

Hsu, J C, Di Pasquale, G, Harunaga, J S, Onodera, T, Hoffman, M P, Chiorini, J A, Yamada, K M · 2012 · Journal of dental research · DOI

Full title: Viral gene transfer to developing mouse salivary glands.

Authors: Hsu, J C, Di Pasquale, G, Harunaga, J S, Onodera, T, Hoffman, M P, Chiorini, J A, Yamada, K M

Year: 2012

Venue: Journal of dental research

DOI: https://doi.org/10.1177/0022034511429346

Paper [Construction of adeno-associated virus vector containing human papilloma virus 16 E7 gene and its expression in eukaryotic cells].

Zhang, Juan, Lin, Zhong-qiu, Peng, Yong-pai, Zhang, Bing-zhong, Zhou, Hui, Yang, Qing-yuan · 2005 · Zhonghua fu chan ke za zhi

Full title: [Construction of adeno-associated virus vector containing human papilloma virus 16 E7 gene and its expression in eukaryotic cells].

Authors: Zhang, Juan, Lin, Zhong-qiu, Peng, Yong-pai, Zhang, Bing-zhong, Zhou, Hui, Yang, Qing-yuan

Year: 2005

Venue: Zhonghua fu chan ke za zhi

Paper Significant Differences in Capsid Properties and Potency Between Adeno-Associated Virus Vectors Produced in Sf9 and HEK293 Cells.

Giles, April, Lock, Martin, Chen, Shu-Jen, Turner, Kevin, Wesolowski, Gregg, Prongay, Andrew, Petkov, Boris N, Olagbegi, Kanyin, Yan, Hanying, Wilson, James M · 2023 · Human gene therapy · DOI

Full title: Significant Differences in Capsid Properties and Potency Between Adeno-Associated Virus Vectors Produced in Sf9 and HEK293 Cells.

Authors: Giles, April, Lock, Martin, Chen, Shu-Jen, Turner, Kevin, Wesolowski, Gregg, Prongay, Andrew, Petkov, Boris N, Olagbegi, Kanyin, Yan, Hanying, Wilson, James M

Year: 2023

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2022.116

Paper Accelerated Adeno Associated Virus Upstream Process Development From High‐Throughput Systems to Clinical Scale

Andaluz, Anna, Monteverde, Brittany, Vera, Kevin, Tse, Brian WC, Gajic, Ivan, Forelich, Clifford, Motevalian, Seyed Pouria · 2025 · Biotechnology and Bioengineering · DOI

Full title: Accelerated Adeno Associated Virus Upstream Process Development From High‐Throughput Systems to Clinical Scale

Authors: Andaluz, Anna, Monteverde, Brittany, Vera, Kevin, Tse, Brian WC, Gajic, Ivan, Forelich, Clifford, Motevalian, Seyed Pouria

Year: 2025

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.70052

Paper Production of High-Yield Adeno Associated Vector Batches Using HEK293 Suspension Cells.

Pietersz, Kimberly L, Nijhuis, Paul J H, Klunder, Matthijs H M, van den Herik, Joëlle, Hobo, Barbara, de Winter, Fred, Verhaagen, Joost · 2024 · Journal of visualized experiments : JoVE · DOI

Full title: Production of High-Yield Adeno Associated Vector Batches Using HEK293 Suspension Cells.

Authors: Pietersz, Kimberly L, Nijhuis, Paul J H, Klunder, Matthijs H M, van den Herik, Joëlle, Hobo, Barbara, de Winter, Fred, Verhaagen, Joost

Year: 2024

Venue: Journal of visualized experiments : JoVE

DOI: https://doi.org/10.3791/66532

Paper Establishment of a novel human amniotic epithelial-derived cell line, HAT, for high-yield AAV vector production.

Hirai, Yugo, Chang, Yu-Hsin, Yamamoto, Arisa, Asahina, Ryo, Moromizato, Rena, Kinoshita, Mawo, Aizawa, Kazuko, Miyai, Manami, Kubota, Michi, Horiuchi, Takayuki, Nakamura, Kazuaki · 2025 · Molecular therapy. Methods & clinical development · DOI

Full title: Establishment of a novel human amniotic epithelial-derived cell line, HAT, for high-yield AAV vector production.

Authors: Hirai, Yugo, Chang, Yu-Hsin, Yamamoto, Arisa, Asahina, Ryo, Moromizato, Rena, Kinoshita, Mawo, Aizawa, Kazuko, Miyai, Manami, Kubota, Michi, Horiuchi, Takayuki, Nakamura, Kazuaki

Year: 2025

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2025.101594

Paper Vector systems for prenatal gene therapy: principles of adeno-associated virus vector design and production.

Binny, Christopher J, Nathwani, Amit C · 2012 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Vector systems for prenatal gene therapy: principles of adeno-associated virus vector design and production.

Authors: Binny, Christopher J, Nathwani, Amit C

Year: 2012

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-61779-873-3_6

Paper A synthetic platform for developing recombinant adeno-associated virus type 8 producer cell lines.

Lin, Yu-Chieh, Kuo, Han-Jung, Lu, Min, Mahl, Thomas, Aslanidi, George, Hu, Wei-Shou · 2025 · Biotechnology progress · DOI

Full title: A synthetic platform for developing recombinant adeno-associated virus type 8 producer cell lines.

Authors: Lin, Yu-Chieh, Kuo, Han-Jung, Lu, Min, Mahl, Thomas, Aslanidi, George, Hu, Wei-Shou

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.70009

Paper Magnetic Field-Assisted Gene Delivery: Achievements and Therapeutic Potential

Schwerdt, José I., Goya, Gerardo F., Calatayud, M. Pilar, Hereñú, Claudia Beatriz, Reggiani, Paula C., Goya, Rodolfo G. · 2012 · Current Gene Therapy · DOI

Full title: Magnetic Field-Assisted Gene Delivery: Achievements and Therapeutic Potential

Authors: Schwerdt, José I., Goya, Gerardo F., Calatayud, M. Pilar, Hereñú, Claudia Beatriz, Reggiani, Paula C., Goya, Rodolfo G.

Year: 2012

Venue: Current Gene Therapy

DOI: https://doi.org/10.2174/156652312800099616

Paper Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing

O’Flaherty, Róisín, Bergin, Adam, Flampouri, Evangelia, Mota, Letícia Martins, Obaidi, Ismael, Quigley, Andrew, Xie, Yongjing, Butler, Michael · 2020 · Biotechnology Advances · DOI

Full title: Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing

Authors: O’Flaherty, Róisín, Bergin, Adam, Flampouri, Evangelia, Mota, Letícia Martins, Obaidi, Ismael, Quigley, Andrew, Xie, Yongjing, Butler, Michael

Year: 2020

Venue: Biotechnology Advances

DOI: https://doi.org/10.1016/j.biotechadv.2020.107552

Paper Enhancing the production of adeno-associated virus (AAV)2 and AAV9 with high full capsid ratio in HEK293 cells through design-of-experiment optimization of triple plasmid ratio.

Park, Sungje, Shin, Seunghyeon, Lee, Haeshin, Jang, Jae-Hyung, Lee, Gyun Min · 2024 · Biotechnology journal · DOI

Full title: Enhancing the production of adeno-associated virus (AAV)2 and AAV9 with high full capsid ratio in HEK293 cells through design-of-experiment optimization of triple plasmid ratio.

Authors: Park, Sungje, Shin, Seunghyeon, Lee, Haeshin, Jang, Jae-Hyung, Lee, Gyun Min

Year: 2024

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202300667

Paper Optimized production of high-titer recombinant adeno-associated virus in roller bottles.

Liu, Y L, Wagner, K, Robinson, N, Sabatino, D, Margaritis, P, Xiao, W, Herzog, R W · 2003 · BioTechniques · DOI

Full title: Optimized production of high-titer recombinant adeno-associated virus in roller bottles.

Authors: Liu, Y L, Wagner, K, Robinson, N, Sabatino, D, Margaritis, P, Xiao, W, Herzog, R W

Year: 2003

Venue: BioTechniques

DOI: https://doi.org/10.2144/03341dd07

Paper Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells.

Nguyen, Tam N T, Sha, Sha, Hong, Moo Sun, Maloney, Andrew J, Barone, Paul W, Neufeld, Caleb, Wolfrum, Jacqueline, Springs, Stacy L, Sinskey, Anthony J, Braatz, Richard D · 2021 · Molecular therapy. Methods & clinical development · DOI

Full title: Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells.

Authors: Nguyen, Tam N T, Sha, Sha, Hong, Moo Sun, Maloney, Andrew J, Barone, Paul W, Neufeld, Caleb, Wolfrum, Jacqueline, Springs, Stacy L, Sinskey, Anthony J, Braatz, Richard D

Year: 2021

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2021.04.006

Paper Rapid and simplified purification of recombinant adeno-associated virus.

Guo, Ping, El-Gohary, Yousef, Prasadan, Krishna, Shiota, Chiyo, Xiao, Xiangwei, Wiersch, John, Paredes, Jose, Tulachan, Sidhartha, Gittes, George K · 2012 · Journal of virological methods · DOI

Full title: Rapid and simplified purification of recombinant adeno-associated virus.

Authors: Guo, Ping, El-Gohary, Yousef, Prasadan, Krishna, Shiota, Chiyo, Xiao, Xiangwei, Wiersch, John, Paredes, Jose, Tulachan, Sidhartha, Gittes, George K

Year: 2012

Venue: Journal of virological methods

DOI: https://doi.org/10.1016/j.jviromet.2012.04.004

Paper Comparative Analysis of HEK293 Genomic Variability.

Smesnik, Georg, Virgolini, Nikolaus, Toth, Maria, Dürauer, Astrid, Borth, Nicole · 2026 · Biotechnology and bioengineering · DOI

Full title: Comparative Analysis of HEK293 Genomic Variability.

Authors: Smesnik, Georg, Virgolini, Nikolaus, Toth, Maria, Dürauer, Astrid, Borth, Nicole

Year: 2026

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.70105

Paper Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection.

Liu, Hao, Zhang, Yue, Yip, Mitchell, Ren, Lingzhi, Liang, Jialing, Chen, Xiupeng, Liu, Nan, Du, Ailing, Wang, Jiaming, Chang, Hao, Oh, Hyejin, Zhou, Chen, Xing, Ruxiao, Xu, Mengyao, Guo, Peiyi, Gessler, Dominic, Xie, Jun, Tai, Phillip W L, Gao, Guangping, Wang, Dan · 2024 · Molecular therapy. Methods & clinical development · DOI

Full title: Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection.

Authors: Liu, Hao, Zhang, Yue, Yip, Mitchell, Ren, Lingzhi, Liang, Jialing, Chen, Xiupeng, Liu, Nan, Du, Ailing, Wang, Jiaming, Chang, Hao, Oh, Hyejin, Zhou, Chen, Xing, Ruxiao, Xu, Mengyao, Guo, Peiyi, Gessler, Dominic, Xie, Jun, Tai, Phillip W L, Gao, Guangping, Wang, Dan

Year: 2024

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2024.101230

Paper Insect cells as a factory to produce adeno-associated virus type 2 vectors.

Urabe, Masashi, Ding, Chuantian, Kotin, Robert M · 2002 · Human gene therapy · DOI

Full title: Insect cells as a factory to produce adeno-associated virus type 2 vectors.

Authors: Urabe, Masashi, Ding, Chuantian, Kotin, Robert M

Year: 2002

Venue: Human gene therapy

DOI: https://doi.org/10.1089/10430340260355347

Paper JoVE Video Dataset

Benyamini, Brian, Esbin, Meagan N., Whitney, Oscar N., Walther, Nike, Maurer, Anna C. · 2023 · DOI

Full title: JoVE Video Dataset

Authors: Benyamini, Brian, Esbin, Meagan N., Whitney, Oscar N., Walther, Nike, Maurer, Anna C.

Year: 2023

DOI: https://doi.org/10.3791/65572-v

Paper A DNA vaccine containing inverted terminal repeats from adeno-associated virus increases immunity to HIV.

Xin, Ke-Qin, Ooki, Takaaki, Jounai, Nao, Mizukami, Hiroaki, Hamajima, Kenji, Kojima, Yoshitsugu, Ohba, Kenji, Toda, Yoshihiko, Hirai, Syu-Ichi, Klinman, Dennis M, Ozawa, Keiya, Okuda, Kenji · 2003 · The journal of gene medicine · DOI

Full title: A DNA vaccine containing inverted terminal repeats from adeno-associated virus increases immunity to HIV.

Authors: Xin, Ke-Qin, Ooki, Takaaki, Jounai, Nao, Mizukami, Hiroaki, Hamajima, Kenji, Kojima, Yoshitsugu, Ohba, Kenji, Toda, Yoshihiko, Hirai, Syu-Ichi, Klinman, Dennis M, Ozawa, Keiya, Okuda, Kenji

Year: 2003

Venue: The journal of gene medicine

DOI: https://doi.org/10.1002/jgm.356

Paper Standardized, Scalable, and Timely Flexible Adeno-Associated Virus Vector Production Using Frozen High-Density HEK-293 Cell Stocks and CELLdiscs.

Strobel, Benjamin, Zuckschwerdt, Kai, Zimmermann, Gudrun, Mayer, Christine, Eytner, Ruth, Rechtsteiner, Philipp, Kreuz, Sebastian, Lamla, Thorsten · 2019 · Human gene therapy methods · DOI

Full title: Standardized, Scalable, and Timely Flexible Adeno-Associated Virus Vector Production Using Frozen High-Density HEK-293 Cell Stocks and CELLdiscs.

Authors: Strobel, Benjamin, Zuckschwerdt, Kai, Zimmermann, Gudrun, Mayer, Christine, Eytner, Ruth, Rechtsteiner, Philipp, Kreuz, Sebastian, Lamla, Thorsten

Year: 2019

Venue: Human gene therapy methods

DOI: https://doi.org/10.1089/hgtb.2018.228

Paper Harnessing cell aggregates for enhanced adeno-associated virus manufacturing: Cultivation strategies and scale-up considerations.

Ladd, Brian, Gräslund, Torbjörn, Chotteau, Véronique · 2025 · Biotechnology progress · DOI

Full title: Harnessing cell aggregates for enhanced adeno-associated virus manufacturing: Cultivation strategies and scale-up considerations.

Authors: Ladd, Brian, Gräslund, Torbjörn, Chotteau, Véronique

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3522

Paper Process Improvement of Adeno-Associated Virus Production

Guan, Jia-Shiung, Chen, Kai, Si, Yingnan, Kim, Tae Hyun, Zhou, Zhuoxin “Zora”, Kim, Seulhee, Zhou, Lufang, Liu, Xiaoguang · 2022 · Frontiers in Chemical Engineering · DOI

Full title: Process Improvement of Adeno-Associated Virus Production

Authors: Guan, Jia-Shiung, Chen, Kai, Si, Yingnan, Kim, Tae Hyun, Zhou, Zhuoxin “Zora”, Kim, Seulhee, Zhou, Lufang, Liu, Xiaoguang

Year: 2022

Venue: Frontiers in Chemical Engineering

DOI: https://doi.org/10.3389/fceng.2022.830421

Paper Comprehensive Comparison of Baculoviral and Plasmid Gene Delivery in Mammalian Cells

Tóth, Mária, Reithofer, Manuel, Dutra, Gregory, Aguilar, Patrícia Pereira, Dürauer, Astrid, Grabherr, Reingard · 2024 · Viruses · DOI

Full title: Comprehensive Comparison of Baculoviral and Plasmid Gene Delivery in Mammalian Cells

Authors: Tóth, Mária, Reithofer, Manuel, Dutra, Gregory, Aguilar, Patrícia Pereira, Dürauer, Astrid, Grabherr, Reingard

Year: 2024

Venue: Viruses

DOI: https://doi.org/10.3390/v16030426

Paper Efficient production of recombinant adeno-associated viral vector, serotype DJ/8, carrying the GFP gene.

Hashimoto, Haruo, Mizushima, Tomoko, Chijiwa, Tsuyoshi, Nakamura, Masato, Suemizu, Hiroshi · 2017 · Virus research · DOI

Full title: Efficient production of recombinant adeno-associated viral vector, serotype DJ/8, carrying the GFP gene.

Authors: Hashimoto, Haruo, Mizushima, Tomoko, Chijiwa, Tsuyoshi, Nakamura, Masato, Suemizu, Hiroshi

Year: 2017

Venue: Virus research

DOI: https://doi.org/10.1016/j.virusres.2017.05.017

Paper In Vivo Delivery of Cassettes Encoding Anti-HBV Primary MicroRNAs Using an Ancestral Adeno-Associated Viral Vector.

Mnyandu, Njabulo, Arbuthnot, Patrick, Maepa, Mohube Betty · 2020 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: In Vivo Delivery of Cassettes Encoding Anti-HBV Primary MicroRNAs Using an Ancestral Adeno-Associated Viral Vector.

Authors: Mnyandu, Njabulo, Arbuthnot, Patrick, Maepa, Mohube Betty

Year: 2020

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-0716-0290-4_10

Paper Delivering multiple gene products in the brain from a single adeno-associated virus vector.

Foti, S B, Samulski, R J, McCown, T J · 2009 · Gene therapy · DOI

Full title: Delivering multiple gene products in the brain from a single adeno-associated virus vector.

Authors: Foti, S B, Samulski, R J, McCown, T J

Year: 2009

Venue: Gene therapy

DOI: https://doi.org/10.1038/gt.2009.106

Paper Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale.

Lock, Martin, Alvira, Mauricio, Vandenberghe, Luk H, Samanta, Arabinda, Toelen, Jaan, Debyser, Zeger, Wilson, James M · 2010 · Human gene therapy · DOI

Full title: Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale.

Authors: Lock, Martin, Alvira, Mauricio, Vandenberghe, Luk H, Samanta, Arabinda, Toelen, Jaan, Debyser, Zeger, Wilson, James M

Year: 2010

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2010.055

Paper Production and titering of recombinant adeno-associated viral vectors.

McClure, Christina, Cole, Katy L H, Wulff, Peer, Klugmann, Matthias, Murray, Andrew J · 2011 · Journal of visualized experiments : JoVE · DOI

Full title: Production and titering of recombinant adeno-associated viral vectors.

Authors: McClure, Christina, Cole, Katy L H, Wulff, Peer, Klugmann, Matthias, Murray, Andrew J

Year: 2011

Venue: Journal of visualized experiments : JoVE

DOI: https://doi.org/10.3791/3348

Paper Characterization of Extracellular Vesicles Secreted in Lentiviral Producing HEK293SF Cell Cultures

Minh, Aline Do, Star, Alexandra T., Stupak, Jacek, Fulton, Kelly M., Haqqani, Arsalan S., Gélinas, Jean‐François, Li, Jianjun, Twine, Susan M., Kamen, Amine · 2021 · Viruses · DOI

Full title: Characterization of Extracellular Vesicles Secreted in Lentiviral Producing HEK293SF Cell Cultures

Authors: Minh, Aline Do, Star, Alexandra T., Stupak, Jacek, Fulton, Kelly M., Haqqani, Arsalan S., Gélinas, Jean‐François, Li, Jianjun, Twine, Susan M., Kamen, Amine

Year: 2021

Venue: Viruses

DOI: https://doi.org/10.3390/v13050797

Paper Characterizing the Biopotency of Truncated Transgene Variants in rAAV8 viral vectors: Essential Considerations for Gene Therapy Applications

Fiedler, Christian, Lengler, Johannes, Gruber, Bernadette, Scheindel, Marcus, Büngener, Carsten, Mittergradnegger, Dominik, Bendik, Marian, Kraus, Barbara, Bort, Juan A. Hernández · 2024 · Research Square (Research Square) · DOI

Full title: Characterizing the Biopotency of Truncated Transgene Variants in rAAV8 viral vectors: Essential Considerations for Gene Therapy Applications

Authors: Fiedler, Christian, Lengler, Johannes, Gruber, Bernadette, Scheindel, Marcus, Büngener, Carsten, Mittergradnegger, Dominik, Bendik, Marian, Kraus, Barbara, Bort, Juan A. Hernández

Year: 2024

Venue: Research Square (Research Square)

DOI: https://doi.org/10.21203/rs.3.rs-4043201/v1

Paper [Establishment and Application of a Model of Well-differentiated Porcine Airway Epithelial Cells in Vitro].

Zhang, Shaodan, Liu, Hongmei, Liu, Zhong, Li, Wuping · 2015 · Bing du xue bao = Chinese journal of virology

Full title: [Establishment and Application of a Model of Well-differentiated Porcine Airway Epithelial Cells in Vitro].

Authors: Zhang, Shaodan, Liu, Hongmei, Liu, Zhong, Li, Wuping

Year: 2015

Venue: Bing du xue bao = Chinese journal of virology

Paper Improving the expression yield of recombinant adeno-associated virus serotype 2 using dimethyl sulfoxide DMSO as an additive to the triple transient transfection process of HEK293 cells.

Burns, Alexander, Ramos-Sono, Daniel, Datta, Saurav · 2025 · Biotechnology progress · DOI

Full title: Improving the expression yield of recombinant adeno-associated virus serotype 2 using dimethyl sulfoxide DMSO as an additive to the triple transient transfection process of HEK293 cells.

Authors: Burns, Alexander, Ramos-Sono, Daniel, Datta, Saurav

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.70017

Paper Rescue of avian adeno-associated virus from a recombinant plasmid containing deletions in the viral inverted terminal repeats.

Wang, Jianye, Zhu, Liqian, Zhu, Jun, Zhang, Xinjun, Tao, Jie, Duan, Qiangde, Zhu, Guoqiang · 2012 · Archives of virology · DOI

Full title: Rescue of avian adeno-associated virus from a recombinant plasmid containing deletions in the viral inverted terminal repeats.

Authors: Wang, Jianye, Zhu, Liqian, Zhu, Jun, Zhang, Xinjun, Tao, Jie, Duan, Qiangde, Zhu, Guoqiang

Year: 2012

Venue: Archives of virology

DOI: https://doi.org/10.1007/s00705-011-1121-x

Paper Development of a Therapeutic CRISPR/Cas9 Platform for Duchenne Muscular Dystrophy

Young, Courtney S. · 2018 · eScholarship (California Digital Library)

Full title: Development of a Therapeutic CRISPR/Cas9 Platform for Duchenne Muscular Dystrophy

Authors: Young, Courtney S.

Year: 2018

Venue: eScholarship (California Digital Library)

Paper Production and Purification of Adeno-Associated Viral Vectors (AAVs) Using Orbitally Shaken HEK293 Cells.

Gaudry, Jean-Philippe, Aebi, Aline, Valdés, Pamela, Schneider, Bernard L · 2024 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Production and Purification of Adeno-Associated Viral Vectors (AAVs) Using Orbitally Shaken HEK293 Cells.

Authors: Gaudry, Jean-Philippe, Aebi, Aline, Valdés, Pamela, Schneider, Bernard L

Year: 2024

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-0716-3878-1_4

Paper Establishment of a Recombinant AAV2/HBoV1 Vector Production System in Insect Cells.

Deng, Xuefeng, Zou, Wei, Yan, Ziying, Qiu, Jianming · 2020 · Genes · DOI

Full title: Establishment of a Recombinant AAV2/HBoV1 Vector Production System in Insect Cells.

Authors: Deng, Xuefeng, Zou, Wei, Yan, Ziying, Qiu, Jianming

Year: 2020

Venue: Genes

DOI: https://doi.org/10.3390/genes11040439

Paper Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays

Buck, Thilo M., Wijnholds, Jan · 2020 · International Journal of Molecular Sciences · DOI

Full title: Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays

Authors: Buck, Thilo M., Wijnholds, Jan

Year: 2020

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms21124197

Paper Biodegradable Polymers for Gene Delivery

Thomas, Thresia, Tajmir‐Riahi, Heidar‐Ali, Pillai, C. K. S. · 2019 · Molecules · DOI

Full title: Biodegradable Polymers for Gene Delivery

Authors: Thomas, Thresia, Tajmir‐Riahi, Heidar‐Ali, Pillai, C. K. S.

Year: 2019

Venue: Molecules

DOI: https://doi.org/10.3390/molecules24203744

Paper Manufacturing Cell and Gene Therapies: Challenges in Clinical Translation

Lee, Na Kyung, Chang, Jong Wook · 2024 · Annals of Laboratory Medicine · DOI

Full title: Manufacturing Cell and Gene Therapies: Challenges in Clinical Translation

Authors: Lee, Na Kyung, Chang, Jong Wook

Year: 2024

Venue: Annals of Laboratory Medicine

DOI: https://doi.org/10.3343/alm.2023.0382

Paper rAAV Production and Titration at the Microscale for High-Throughput Screening.

Quan, David Nathan, Shiloach, Joseph · 2022 · Human gene therapy · DOI

Full title: rAAV Production and Titration at the Microscale for High-Throughput Screening.

Authors: Quan, David Nathan, Shiloach, Joseph

Year: 2022

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2021.080

Paper Development of carbamate modified PEI for delivery of a granzyme B inhibitor gene to protect against cytotoxic lymphocyte killing

Cheng, Wei · 2013 · Spiral (Imperial College London) · DOI

Full title: Development of carbamate modified PEI for delivery of a granzyme B inhibitor gene to protect against cytotoxic lymphocyte killing

Authors: Cheng, Wei

Year: 2013

Venue: Spiral (Imperial College London)

DOI: https://doi.org/10.25560/23983

Paper Sodium Chloride Enhances Recombinant Adeno-Associated Virus Production in a Serum-Free Suspension Manufacturing Platform Using the Herpes Simplex Virus System.

Adamson-Small, Laura, Potter, Mark, Byrne, Barry J, Clément, Nathalie · 2017 · Human gene therapy methods · DOI

Full title: Sodium Chloride Enhances Recombinant Adeno-Associated Virus Production in a Serum-Free Suspension Manufacturing Platform Using the Herpes Simplex Virus System.

Authors: Adamson-Small, Laura, Potter, Mark, Byrne, Barry J, Clément, Nathalie

Year: 2017

Venue: Human gene therapy methods

DOI: https://doi.org/10.1089/hgtb.2016.151

Paper [A recombinant adeno-associated virus expressing secretory TGF-β type Ⅱ receptor inhibits triple-negative murine breast cancer 4T1 cell proliferation and lung metastasis in mice].

Cui, Z, Ma, C, Wang, Q, Chen, J, Yan, Z, Yang, J, Lü, Y, Cao, C · 2024 · Nan fang yi ke da xue xue bao = Journal of Southern Medical University · DOI

Full title: [A recombinant adeno-associated virus expressing secretory TGF-β type Ⅱ receptor inhibits triple-negative murine breast cancer 4T1 cell proliferation and lung metastasis in mice].

Authors: Cui, Z, Ma, C, Wang, Q, Chen, J, Yan, Z, Yang, J, Lü, Y, Cao, C

Year: 2024

Venue: Nan fang yi ke da xue xue bao = Journal of Southern Medical University

DOI: https://doi.org/10.12122/j.issn.1673-4254.2024.05.03

Paper Perfusion-Based Production of rAAV via an Intensified Transient Transfection Process.

Nguyen, Tam N T, Park, Damdae, Canova, Christopher T, Sangerman, Jose, Srinivasan, Prasanna, Ou, Rui Wen, Barone, Paul W, Neufeld, Caleb, Wolfrum, Jacqueline M, Springs, Stacy L, Sinskey, Anthony J, Braatz, Richard D · 2025 · Biotechnology and bioengineering · DOI

Full title: Perfusion-Based Production of rAAV via an Intensified Transient Transfection Process.

Authors: Nguyen, Tam N T, Park, Damdae, Canova, Christopher T, Sangerman, Jose, Srinivasan, Prasanna, Ou, Rui Wen, Barone, Paul W, Neufeld, Caleb, Wolfrum, Jacqueline M, Springs, Stacy L, Sinskey, Anthony J, Braatz, Richard D

Year: 2025

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28967

Paper Rational plasmid design and bioprocess optimization to enhance recombinant adeno-associated virus (AAV) productivity in mammalian cells.

Emmerling, Verena V, Pegel, Antje, Milian, Ernest G, Venereo-Sanchez, Alina, Kunz, Marion, Wegele, Jessica, Kamen, Amine A, Kochanek, Stefan, Hoerer, Markus · 2016 · Biotechnology journal · DOI

Full title: Rational plasmid design and bioprocess optimization to enhance recombinant adeno-associated virus (AAV) productivity in mammalian cells.

Authors: Emmerling, Verena V, Pegel, Antje, Milian, Ernest G, Venereo-Sanchez, Alina, Kunz, Marion, Wegele, Jessica, Kamen, Amine A, Kochanek, Stefan, Hoerer, Markus

Year: 2016

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201500176

Paper Continuous Collection of Adeno-Associated Virus from Producer Cell Medium Significantly Increases Total Viral Yield.

Benskey, Matthew J, Sandoval, Ivette M, Manfredsson, Fredric P · 2016 · Human gene therapy methods · DOI

Full title: Continuous Collection of Adeno-Associated Virus from Producer Cell Medium Significantly Increases Total Viral Yield.

Authors: Benskey, Matthew J, Sandoval, Ivette M, Manfredsson, Fredric P

Year: 2016

Venue: Human gene therapy methods

DOI: https://doi.org/10.1089/hgtb.2015.117

Paper Construction and optimization of novel recombinant Adeno-Associated Virus rAAV2/5 for targeting microglia to regulate immune responses during neuroinflammation

Belhoul‐Fakir, Hanane · 2014 · DOI

Full title: Construction and optimization of novel recombinant Adeno-Associated Virus rAAV2/5 for targeting microglia to regulate immune responses during neuroinflammation

Authors: Belhoul‐Fakir, Hanane

Year: 2014

DOI: https://doi.org/10.26686/wgtn.17008231.v1

Paper [Expression and Regulatory Effect of miR-30b on Dynamin in Cochlear Hair Cells].

Li, Yang, Tang, Xiao-Lin, Yu, Fei, Li, Hua-Jun, Yuan, Wei · 2018 · Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

Full title: [Expression and Regulatory Effect of miR-30b on Dynamin in Cochlear Hair Cells].

Authors: Li, Yang, Tang, Xiao-Lin, Yu, Fei, Li, Hua-Jun, Yuan, Wei

Year: 2018

Venue: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

Paper Design space determination to optimize DNA complexation and full capsid formation in transient rAAV manufacturing

Fu, Qiang, Lee, Yong Suk, Green, Erica A., Wang, Yongdan, Park, So Young, Polanco, Ashli, Lee, Kelvin H., Betenbaugh, Michael J., McNally, David, Yoon, Seongkyu · 2023 · Biotechnology and Bioengineering · DOI

Full title: Design space determination to optimize DNA complexation and full capsid formation in transient rAAV manufacturing

Authors: Fu, Qiang, Lee, Yong Suk, Green, Erica A., Wang, Yongdan, Park, So Young, Polanco, Ashli, Lee, Kelvin H., Betenbaugh, Michael J., McNally, David, Yoon, Seongkyu

Year: 2023

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28508

Paper MUTAGENESIS OF AAV CAPSID PROTEINS FOR ENHANCED TRANSDUCTION OF CARDIAC CELL TYPES

Latricia, Bowman, · 2015

Full title: MUTAGENESIS OF AAV CAPSID PROTEINS FOR ENHANCED TRANSDUCTION OF CARDIAC CELL TYPES

Authors: Latricia, Bowman,

Year: 2015

Paper Improved productivity of recombinant adeno-associated virus (rAAV) via triple transfection of HEK293 cells using perfusion cultivation.

Nie, Jianqi, Xu, Zhaojing, Sun, Yang, Ren, He, Song, Zichuan, Zhang, Yan, Bai, Zhonghu · 2025 · Bioprocess and biosystems engineering · DOI

Full title: Improved productivity of recombinant adeno-associated virus (rAAV) via triple transfection of HEK293 cells using perfusion cultivation.

Authors: Nie, Jianqi, Xu, Zhaojing, Sun, Yang, Ren, He, Song, Zichuan, Zhang, Yan, Bai, Zhonghu

Year: 2025

Venue: Bioprocess and biosystems engineering

DOI: https://doi.org/10.1007/s00449-025-03167-9

Paper [The construction of recombinant AAV vector expressing HSVtk gene controlled by Tet-On and the detection of its activity].

Chen, Qian, Li, Zi-Bo, Zeng, Zhao-Jun, Luo, Sai-Qun, Hu, Wei-Xin · 2005 · Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Full title: [The construction of recombinant AAV vector expressing HSVtk gene controlled by Tet-On and the detection of its activity].

Authors: Chen, Qian, Li, Zi-Bo, Zeng, Zhao-Jun, Luo, Sai-Qun, Hu, Wei-Xin

Year: 2005

Venue: Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Paper Silencing Genes in the Heart.

Fechner, Henry, Vetter, Roland, Kurreck, Jens, Poller, Wolfgang · 2017 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Silencing Genes in the Heart.

Authors: Fechner, Henry, Vetter, Roland, Kurreck, Jens, Poller, Wolfgang

Year: 2017

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-4939-6588-5_2

Paper Production of rAAV by plasmid transfection induces antiviral and inflammatory responses in suspension HEK293 cells.

Chung, Cheng-Han, Murphy, Christopher M, Wingate, Vincent P, Pavlicek, Jeffrey W, Nakashima, Reiko, Wei, Wei, McCarty, Douglas, Rabinowitz, Joseph, Barton, Erik · 2023 · Molecular therapy. Methods & clinical development · DOI

Full title: Production of rAAV by plasmid transfection induces antiviral and inflammatory responses in suspension HEK293 cells.

Authors: Chung, Cheng-Han, Murphy, Christopher M, Wingate, Vincent P, Pavlicek, Jeffrey W, Nakashima, Reiko, Wei, Wei, McCarty, Douglas, Rabinowitz, Joseph, Barton, Erik

Year: 2023

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2023.01.002

Paper Large-Scale Production of Lentiviral Vectors: Current Perspectives and Challenges

Martínez-Molina, Eduardo, Chocarro‐Wrona, Carlos, Martínez‐Moreno, Daniel, Marchal, Juan Antonio, Boulaiz, Houría · 2020 · Pharmaceutics · DOI

Full title: Large-Scale Production of Lentiviral Vectors: Current Perspectives and Challenges

Authors: Martínez-Molina, Eduardo, Chocarro‐Wrona, Carlos, Martínez‐Moreno, Daniel, Marchal, Juan Antonio, Boulaiz, Houría

Year: 2020

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics12111051

Paper Extracellular vesicles enhance pulmonary transduction of stably associated adeno‐associated virus following intratracheal administration

Kwak, Gijung, Гололобова, Олеся, Sharma, Neeraj, Caine, Colin, Mazur, Marina, Mulka, Kathleen R., West, Natalie E., Solomon, George M., Cutting, Garry R., Witwer, Kenneth W., Rowe, Steven M., Paulaitis, Michael E., Aslanidi, George, Suk, Jung Soo · 2023 · Journal of Extracellular Vesicles · DOI

Full title: Extracellular vesicles enhance pulmonary transduction of stably associated adeno‐associated virus following intratracheal administration

Authors: Kwak, Gijung, Гололобова, Олеся, Sharma, Neeraj, Caine, Colin, Mazur, Marina, Mulka, Kathleen R., West, Natalie E., Solomon, George M., Cutting, Garry R., Witwer, Kenneth W., Rowe, Steven M., Paulaitis, Michael E., Aslanidi, George, Suk, Jung Soo

Year: 2023

Venue: Journal of Extracellular Vesicles

DOI: https://doi.org/10.1002/jev2.12324

Paper High-yield recombinant adeno-associated viral vector production by multivariate optimization of bioprocess and transfection conditions.

Coplan, Louis, Zhang, Zhe, Ragone, Nicole, Reeves, John, Rodriguez, Audrey, Shevade, Aishwarya, Bak, Hanne, Tustian, Andrew D · 2024 · Biotechnology progress · DOI

Full title: High-yield recombinant adeno-associated viral vector production by multivariate optimization of bioprocess and transfection conditions.

Authors: Coplan, Louis, Zhang, Zhe, Ragone, Nicole, Reeves, John, Rodriguez, Audrey, Shevade, Aishwarya, Bak, Hanne, Tustian, Andrew D

Year: 2024

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3445

Paper Efficient production of dual recombinant adeno-associated viral vectors for factor VIII delivery.

Wang, Qizhao, Dong, Biao, Firrman, Jenni, Roberts, Sean, Moore, Andrea Rossi, Cao, Wenjing, Diao, Yong, Kapranov, Philipp, Xu, Ruian, Xiao, Weidong · 2014 · Human gene therapy methods · DOI

Full title: Efficient production of dual recombinant adeno-associated viral vectors for factor VIII delivery.

Authors: Wang, Qizhao, Dong, Biao, Firrman, Jenni, Roberts, Sean, Moore, Andrea Rossi, Cao, Wenjing, Diao, Yong, Kapranov, Philipp, Xu, Ruian, Xiao, Weidong

Year: 2014

Venue: Human gene therapy methods

DOI: https://doi.org/10.1089/hgtb.2014.093

Paper Methods Matter: Standard Production Platforms for Recombinant AAV Produce Chemically and Functionally Distinct Vectors.

Rumachik, Neil G, Malaker, Stacy A, Poweleit, Nicole, Maynard, Lucy H, Adams, Christopher M, Leib, Ryan D, Cirolia, Giana, Thomas, Dennis, Stamnes, Susan, Holt, Kathleen, Sinn, Patrick, May, Andrew P, Paulk, Nicole K · 2020 · Molecular therapy. Methods & clinical development · DOI

Full title: Methods Matter: Standard Production Platforms for Recombinant AAV Produce Chemically and Functionally Distinct Vectors.

Authors: Rumachik, Neil G, Malaker, Stacy A, Poweleit, Nicole, Maynard, Lucy H, Adams, Christopher M, Leib, Ryan D, Cirolia, Giana, Thomas, Dennis, Stamnes, Susan, Holt, Kathleen, Sinn, Patrick, May, Andrew P, Paulk, Nicole K

Year: 2020

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2020.05.018

Paper Downregulation of α-Synuclein Protein Levels by an Intracellular Single-Chain Antibody.

Chen, Yun-Hsiang, Yu, Seong-Jin, Wu, Kuo-Jen, Wang, Yu-Syuan, Tsai, Ho-Min, Liao, Li-Wen, Chen, Shuchun, Hsieh, Wei, Chen, Hsi, Hsu, Shu-Ching, Chen, Mao-Liang, Hoffer, Barry J, Wang, Yun · 2020 · Journal of Parkinson's disease · DOI

Full title: Downregulation of α-Synuclein Protein Levels by an Intracellular Single-Chain Antibody.

Authors: Chen, Yun-Hsiang, Yu, Seong-Jin, Wu, Kuo-Jen, Wang, Yu-Syuan, Tsai, Ho-Min, Liao, Li-Wen, Chen, Shuchun, Hsieh, Wei, Chen, Hsi, Hsu, Shu-Ching, Chen, Mao-Liang, Hoffer, Barry J, Wang, Yun

Year: 2020

Venue: Journal of Parkinson's disease

DOI: https://doi.org/10.3233/JPD-191787

Paper Advancements in Insect-Cell Baculovirus Expression Vector Platform for Production of Recombinant Adeno-Associated Virus-Based Gene Delivery Vectors

Joshi, Pranav R.H., Sanchez, Alina Venereo, Chahal, Parminder S., Kamen, Amine · 2020 · Authorea · DOI

Full title: Advancements in Insect-Cell Baculovirus Expression Vector Platform for Production of Recombinant Adeno-Associated Virus-Based Gene Delivery Vectors

Authors: Joshi, Pranav R.H., Sanchez, Alina Venereo, Chahal, Parminder S., Kamen, Amine

Year: 2020

Venue: Authorea

DOI: https://doi.org/10.22541/au.158750380.04327747

Paper Unraveling Cytotoxicity in HEK293 Cells During Recombinant AAV Production for Gene Therapy Applications.

Ladiwala, Pranay, Ndahiro, Nelson, Hauk, Pricila, Wen, Junneng, Sargunas, Justin, Chen, Yu-Ju, Barton, Erik, Betenbaugh, Michael J · 2025 · Biotechnology journal · DOI

Full title: Unraveling Cytotoxicity in HEK293 Cells During Recombinant AAV Production for Gene Therapy Applications.

Authors: Ladiwala, Pranay, Ndahiro, Nelson, Hauk, Pricila, Wen, Junneng, Sargunas, Justin, Chen, Yu-Ju, Barton, Erik, Betenbaugh, Michael J

Year: 2025

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202400501

Paper Towards a scalable bioprocess for rAAV production using a HeLa stable cell line.

Escandell, José, Moura, Filipa, Carvalho, Sofia B, Silva, Ricardo J S, Correia, Ricardo, Roldão, Antonio, Gomes-Alves, Patrícia, Alves, Paula M · 2023 · Biotechnology and bioengineering · DOI

Full title: Towards a scalable bioprocess for rAAV production using a HeLa stable cell line.

Authors: Escandell, José, Moura, Filipa, Carvalho, Sofia B, Silva, Ricardo J S, Correia, Ricardo, Roldão, Antonio, Gomes-Alves, Patrícia, Alves, Paula M

Year: 2023

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28394

Paper Scalable Production and Purification of Adeno-Associated Viral Vectors (AAV).

Blessing, Daniel, Déglon, Nicole, Schneider, Bernard L · 2018 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Scalable Production and Purification of Adeno-Associated Viral Vectors (AAV).

Authors: Blessing, Daniel, Déglon, Nicole, Schneider, Bernard L

Year: 2018

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-4939-8730-6_17

Paper Cas-CLOVER-mediated knockout of STAT1: A novel approach to engineer packaging HEK-293 cell lines used for rAAV production.

Andorfer, Peter, Kahlig, Carolin-Isabel, Pakusic, Doris, Pachlinger, Robert, John, Christiane, Schrenk, Irene, Eisenhut, Peter, Lengler, Johannes, Innthaler, Bernd, Micutkova, Lucia, Kraus, Barbara, Brizzee, Corey, Crawford, Jack, Hernandez Bort, Juan A · 2024 · Biotechnology journal · DOI

Full title: Cas-CLOVER-mediated knockout of STAT1: A novel approach to engineer packaging HEK-293 cell lines used for rAAV production.

Authors: Andorfer, Peter, Kahlig, Carolin-Isabel, Pakusic, Doris, Pachlinger, Robert, John, Christiane, Schrenk, Irene, Eisenhut, Peter, Lengler, Johannes, Innthaler, Bernd, Micutkova, Lucia, Kraus, Barbara, Brizzee, Corey, Crawford, Jack, Hernandez Bort, Juan A

Year: 2024

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202400415

Paper DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease.

Arkan, Sertan, Ljungberg, Mårten, Kirik, Deniz, Hansen, Christian · 2021 · Neurobiology of disease · DOI

Full title: DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease.

Authors: Arkan, Sertan, Ljungberg, Mårten, Kirik, Deniz, Hansen, Christian

Year: 2021

Venue: Neurobiology of disease

DOI: https://doi.org/10.1016/j.nbd.2021.105477

Paper Development of an HEK293 Suspension Cell Culture Medium, Transient Transfection Optimization Workflow, and Analytics for Batch rAAV Manufacturing.

Green, Erica A, Fu, Qiang, Ndahiro, Nelson, Leibiger, Thomas M, Wang, Yongdan, Lee, Yongsuk, Lee, Kelvin H, Betenbaugh, Michael, Yoon, Seongkyu, McNally, David J · 2025 · Biotechnology and bioengineering · DOI

Full title: Development of an HEK293 Suspension Cell Culture Medium, Transient Transfection Optimization Workflow, and Analytics for Batch rAAV Manufacturing.

Authors: Green, Erica A, Fu, Qiang, Ndahiro, Nelson, Leibiger, Thomas M, Wang, Yongdan, Lee, Yongsuk, Lee, Kelvin H, Betenbaugh, Michael, Yoon, Seongkyu, McNally, David J

Year: 2025

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28980

Paper Production of adeno-associated virus (AAV) serotypes by transient transfection of HEK293 cell suspension cultures for gene delivery.

Chahal, Parminder Singh, Schulze, Erica, Tran, Rosa, Montes, Johnny, Kamen, Amine A · 2014 · Journal of virological methods · DOI

Full title: Production of adeno-associated virus (AAV) serotypes by transient transfection of HEK293 cell suspension cultures for gene delivery.

Authors: Chahal, Parminder Singh, Schulze, Erica, Tran, Rosa, Montes, Johnny, Kamen, Amine A

Year: 2014

Venue: Journal of virological methods

DOI: https://doi.org/10.1016/j.jviromet.2013.10.038

Paper Construction of adeno-associated virus system for human bone morphogenetic protein 7 gene.

Song, Ke, Rao, Nianjing, Chen, Meiling, Cao, Yingguang · 2008 · Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · DOI

Full title: Construction of adeno-associated virus system for human bone morphogenetic protein 7 gene.

Authors: Song, Ke, Rao, Nianjing, Chen, Meiling, Cao, Yingguang

Year: 2008

Venue: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban

DOI: https://doi.org/10.1007/s11596-008-0105-x

Paper Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences.

Trivedi, Prasad D, Yu, Chenghui, Chaudhuri, Payel, Johnson, Evan J, Caton, Tina, Adamson, Laura, Byrne, Barry J, Paulk, Nicole K, Clément, Nathalie · 2022 · Molecular therapy. Methods & clinical development · DOI

Full title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences.

Authors: Trivedi, Prasad D, Yu, Chenghui, Chaudhuri, Payel, Johnson, Evan J, Caton, Tina, Adamson, Laura, Byrne, Barry J, Paulk, Nicole K, Clément, Nathalie

Year: 2022

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2021.12.006

Paper [Construction and expression of adeno-associated virus vectors of Smad 6 and Smad 7 genes in human renal tubule epithelial cells].

Huang, Yun-Jian, Zhao, Jing-Hong, Yang, Tang-Jun, Zhang, Jin-Hai, Cai, Wen-Qin · 2004 · Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

Full title: [Construction and expression of adeno-associated virus vectors of Smad 6 and Smad 7 genes in human renal tubule epithelial cells].

Authors: Huang, Yun-Jian, Zhao, Jing-Hong, Yang, Tang-Jun, Zhang, Jin-Hai, Cai, Wen-Qin

Year: 2004

Venue: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

Paper High-cell-density production of adeno-associated viral vector serotype 6 by triple transfection in suspension HEK293 cell cultures

Moço, Pablo Diego, Xu, Xingge, Kamen, Amine · 2023 · DOI

Full title: High-cell-density production of adeno-associated viral vector serotype 6 by triple transfection in suspension HEK293 cell cultures

Authors: Moço, Pablo Diego, Xu, Xingge, Kamen, Amine

Year: 2023

DOI: https://doi.org/10.22541/au.167535214.41739207/v1

Paper Therapeutic potential of AAV8-mediated IL-17RA extracellular domain gene delivery in an imiquimod-induced mouse model of psoriasis.

Xie, Huibin, Li, Danping, Cao, Yu, Lv, Yafeng, Cao, Chunyu, Wu, Hongyan · 2025 · Molecular immunology · DOI

Full title: Therapeutic potential of AAV8-mediated IL-17RA extracellular domain gene delivery in an imiquimod-induced mouse model of psoriasis.

Authors: Xie, Huibin, Li, Danping, Cao, Yu, Lv, Yafeng, Cao, Chunyu, Wu, Hongyan

Year: 2025

Venue: Molecular immunology

DOI: https://doi.org/10.1016/j.molimm.2025.11.001

Paper Potency by design: Novel insights in transfection and purification for manufacturing of rAAV gene therapy vectors.

Maccani, Andreas, Pachlinger, Robert, Eisenhut, Peter, Unterthurner, Sabine, Heider, Susanne, Repik, Christoph, Reuberger, Stefan, Andorfer, Peter, Lengler, Johannes, Kinastberger, Bernhard, Seczer, Dieter, Gruber, Petra, Apschner, Alexander, Micutkova, Lucia · 2025 · Journal of biotechnology · DOI

Full title: Potency by design: Novel insights in transfection and purification for manufacturing of rAAV gene therapy vectors.

Authors: Maccani, Andreas, Pachlinger, Robert, Eisenhut, Peter, Unterthurner, Sabine, Heider, Susanne, Repik, Christoph, Reuberger, Stefan, Andorfer, Peter, Lengler, Johannes, Kinastberger, Bernhard, Seczer, Dieter, Gruber, Petra, Apschner, Alexander, Micutkova, Lucia

Year: 2025

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2024.12.007

Paper Transduction efficiency of AAV 2/6, 2/8 and 2/9 vectors for delivering genes in human corneal fibroblasts.

Sharma, Ajay, Ghosh, Arkasubhra, Hansen, Eric T, Newman, Jason M, Mohan, Rajiv R · 2010 · Brain research bulletin · DOI

Full title: Transduction efficiency of AAV 2/6, 2/8 and 2/9 vectors for delivering genes in human corneal fibroblasts.

Authors: Sharma, Ajay, Ghosh, Arkasubhra, Hansen, Eric T, Newman, Jason M, Mohan, Rajiv R

Year: 2010

Venue: Brain research bulletin

DOI: https://doi.org/10.1016/j.brainresbull.2009.07.005

Paper Human and Insect Cell-Produced Recombinant Adeno-Associated Viruses Show Differences in Genome Heterogeneity.

Tran, Ngoc Tam, Lecomte, Emilie, Saleun, Sylvie, Namkung, Suk, Robin, Cécile, Weber, Kristina, Devine, Eric, Blouin, Veronique, Adjali, Oumeya, Ayuso, Eduard, Gao, Guangping, Penaud-Budloo, Magalie, Tai, Phillip W L · 2022 · Human gene therapy · DOI

Full title: Human and Insect Cell-Produced Recombinant Adeno-Associated Viruses Show Differences in Genome Heterogeneity.

Authors: Tran, Ngoc Tam, Lecomte, Emilie, Saleun, Sylvie, Namkung, Suk, Robin, Cécile, Weber, Kristina, Devine, Eric, Blouin, Veronique, Adjali, Oumeya, Ayuso, Eduard, Gao, Guangping, Penaud-Budloo, Magalie, Tai, Phillip W L

Year: 2022

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2022.050

Paper Deciphering Key Adenoviral Elements in the Production of Recombinant Adeno-Associated Virus Vectors.

Fernandes, Sofia, Guerra, Júlia, Ferreira, Mariana V, Coroadinha, Ana Sofia · 2025 · Human gene therapy · DOI

Full title: Deciphering Key Adenoviral Elements in the Production of Recombinant Adeno-Associated Virus Vectors.

Authors: Fernandes, Sofia, Guerra, Júlia, Ferreira, Mariana V, Coroadinha, Ana Sofia

Year: 2025

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2024.265

Paper Engineering pseudovirions for large-scale targeted gene transfer and recombinant adeno-associated virus production

Asavarut, Paladd · 2018 · Spiral (Imperial College London) · DOI

Full title: Engineering pseudovirions for large-scale targeted gene transfer and recombinant adeno-associated virus production

Authors: Asavarut, Paladd

Year: 2018

Venue: Spiral (Imperial College London)

DOI: https://doi.org/10.25560/86379

Paper Preclinical evaluation of a recombinant adeno-associated virus vector expressing human alpha-1 antitrypsin made using a recombinant herpes simplex virus production method.

Chulay, Jeffrey D, Ye, Guo-Jie, Thomas, Darby L, Knop, David R, Benson, Janet M, Hutt, Julie A, Wang, Gensheng, Humphries, Margaret, Flotte, Terence R · 2011 · Human gene therapy · DOI

Full title: Preclinical evaluation of a recombinant adeno-associated virus vector expressing human alpha-1 antitrypsin made using a recombinant herpes simplex virus production method.

Authors: Chulay, Jeffrey D, Ye, Guo-Jie, Thomas, Darby L, Knop, David R, Benson, Janet M, Hutt, Julie A, Wang, Gensheng, Humphries, Margaret, Flotte, Terence R

Year: 2011

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2010.118

Paper Progress and challenges in viral vector manufacturing

Loo, Johannes C.M. van der, Wright, J. Fraser · 2015 · Human Molecular Genetics · DOI

Full title: Progress and challenges in viral vector manufacturing

Authors: Loo, Johannes C.M. van der, Wright, J. Fraser

Year: 2015

Venue: Human Molecular Genetics

DOI: https://doi.org/10.1093/hmg/ddv451

Paper Ultracentrifugation-free chromatography-mediated large-scale purification of recombinant adeno-associated virus serotype 1 (rAAV1).

Tomono, Taro, Hirai, Yukihiko, Okada, Hironori, Adachi, Kumi, Ishii, Akiko, Shimada, Takashi, Onodera, Masafumi, Tamaoka, Akira, Okada, Takashi · 2016 · Molecular therapy. Methods & clinical development · DOI

Full title: Ultracentrifugation-free chromatography-mediated large-scale purification of recombinant adeno-associated virus serotype 1 (rAAV1).

Authors: Tomono, Taro, Hirai, Yukihiko, Okada, Hironori, Adachi, Kumi, Ishii, Akiko, Shimada, Takashi, Onodera, Masafumi, Tamaoka, Akira, Okada, Takashi

Year: 2016

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1038/mtm.2015.58

Paper In-Depth Comparison of Adeno-Associated Virus Containing Fractions after CsCl Ultracentrifugation Gradient Separation

Janc, M., Zevnik, Kaja, Dolinar, Ana, Jakomin, Tjaša, Štalekar, Maja, Bačnik, Katarina, Kutnjak, Denis, Žnidarič, Magda Tušek, Zentilin, Lorena, Fedorov, D. L., Dobnik, David · 2024 · Viruses · DOI

Full title: In-Depth Comparison of Adeno-Associated Virus Containing Fractions after CsCl Ultracentrifugation Gradient Separation

Authors: Janc, M., Zevnik, Kaja, Dolinar, Ana, Jakomin, Tjaša, Štalekar, Maja, Bačnik, Katarina, Kutnjak, Denis, Žnidarič, Magda Tušek, Zentilin, Lorena, Fedorov, D. L., Dobnik, David

Year: 2024

Venue: Viruses

DOI: https://doi.org/10.3390/v16081235

Paper Human Bocavirus 1 Is a Novel Helper for Adeno-associated Virus Replication.

Wang, Zekun, Deng, Xuefeng, Zou, Wei, Engelhardt, John F, Yan, Ziying, Qiu, Jianming · 2017 · Journal of virology · DOI

Full title: Human Bocavirus 1 Is a Novel Helper for Adeno-associated Virus Replication.

Authors: Wang, Zekun, Deng, Xuefeng, Zou, Wei, Engelhardt, John F, Yan, Ziying, Qiu, Jianming

Year: 2017

Venue: Journal of virology

DOI: https://doi.org/10.1128/JVI.00710-17

Paper Production, Purification, and Quality Control for Adeno-associated Virus-based Vectors

Fripont, Shelly, Marneffe, Catherine, Marino, Marika, Rincón, Melvin Y., Holt, Matthew G. · 2019 · Journal of Visualized Experiments · DOI

Full title: Production, Purification, and Quality Control for Adeno-associated Virus-based Vectors

Authors: Fripont, Shelly, Marneffe, Catherine, Marino, Marika, Rincón, Melvin Y., Holt, Matthew G.

Year: 2019

Venue: Journal of Visualized Experiments

DOI: https://doi.org/10.3791/58960

Paper Intensification of rAAV Production Based on HEK293 Cell Transient Transfection.

Zhang, Ye, Peters, Emil Sundäng, Daramola, Olalekan, Tucker, Trudy Ann, Rockberg, Johan, Hatton, Diane, Chotteau, Véronique · 2025 · Biotechnology journal · DOI

Full title: Intensification of rAAV Production Based on HEK293 Cell Transient Transfection.

Authors: Zhang, Ye, Peters, Emil Sundäng, Daramola, Olalekan, Tucker, Trudy Ann, Rockberg, Johan, Hatton, Diane, Chotteau, Véronique

Year: 2025

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.70020

Paper Enhanced cellular transfection by ternary non-viral gene vectors coupled with adeno-associated virus-derived peptides.

Oh, Ji-Seon, Park, Minah, Kim, Jung-Suk, Jang, Jae-Hyung · 2014 · Macromolecular bioscience · DOI

Full title: Enhanced cellular transfection by ternary non-viral gene vectors coupled with adeno-associated virus-derived peptides.

Authors: Oh, Ji-Seon, Park, Minah, Kim, Jung-Suk, Jang, Jae-Hyung

Year: 2014

Venue: Macromolecular bioscience

DOI: https://doi.org/10.1002/mabi.201300296

Paper AAV2-mediated ABD-FGF21 gene delivery produces a sustained anti-hyperglycemic effect in type 2 diabetic mouse.

Lu, Sen-Lin, Pan, Zhi-Hao, Cui, Zhi, Wang, Ji-Li, Yang, Jian-Lin, Lv, Ya-Feng, Cao, Chun-Yu, Huang, Xiao-Fei · 2025 · Life sciences · DOI

Full title: AAV2-mediated ABD-FGF21 gene delivery produces a sustained anti-hyperglycemic effect in type 2 diabetic mouse.

Authors: Lu, Sen-Lin, Pan, Zhi-Hao, Cui, Zhi, Wang, Ji-Li, Yang, Jian-Lin, Lv, Ya-Feng, Cao, Chun-Yu, Huang, Xiao-Fei

Year: 2025

Venue: Life sciences

DOI: https://doi.org/10.1016/j.lfs.2024.123344

Paper Critical challenges and advances in recombinant adeno‐associated virus (rAAV) biomanufacturing

Fu, Qiang, Polanco, Ashli, Lee, Yong Suk, Yoon, Seongkyu · 2023 · Biotechnology and Bioengineering · DOI

Full title: Critical challenges and advances in recombinant adeno‐associated virus (rAAV) biomanufacturing

Authors: Fu, Qiang, Polanco, Ashli, Lee, Yong Suk, Yoon, Seongkyu

Year: 2023

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28412

Paper How will the field of gene therapy survive its success?

Kaemmerer, William F. · 2018 · Bioengineering & Translational Medicine · DOI

Full title: How will the field of gene therapy survive its success?

Authors: Kaemmerer, William F.

Year: 2018

Venue: Bioengineering & Translational Medicine

DOI: https://doi.org/10.1002/btm2.10090

Paper Factors affecting recombinant Adeno-Associated Virus titers during triple-plasmid transient transfection in HEK-293 cells

Pistek, Martina, Andorfer, Peter, Grabherr, Reingard, Kraus, Barbara, Bort, Juan A. Hernández · 2024 · Research Square (Research Square) · DOI

Full title: Factors affecting recombinant Adeno-Associated Virus titers during triple-plasmid transient transfection in HEK-293 cells

Authors: Pistek, Martina, Andorfer, Peter, Grabherr, Reingard, Kraus, Barbara, Bort, Juan A. Hernández

Year: 2024

Venue: Research Square (Research Square)

DOI: https://doi.org/10.21203/rs.3.rs-4252754/v1

Paper A concept of eliminating nonhomologous recombination for scalable and safe AAV vector generation for human gene therapy.

Dong, Biao, Moore, Andrea R, Dai, Jihong, Roberts, Sean, Chu, Kirk, Kapranov, Philipp, Moss, Bernard, Xiao, Weidong · 2013 · Nucleic acids research · DOI

Full title: A concept of eliminating nonhomologous recombination for scalable and safe AAV vector generation for human gene therapy.

Authors: Dong, Biao, Moore, Andrea R, Dai, Jihong, Roberts, Sean, Chu, Kirk, Kapranov, Philipp, Moss, Bernard, Xiao, Weidong

Year: 2013

Venue: Nucleic acids research

DOI: https://doi.org/10.1093/nar/gkt404

Paper Bioluminescence-based monitoring of virus vector-mediated gene transfer in mice.

Maguire, Casey A · 2014 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Bioluminescence-based monitoring of virus vector-mediated gene transfer in mice.

Authors: Maguire, Casey A

Year: 2014

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-62703-718-1_16

Paper A Rapid, Cost-Effective Method to Prepare Recombinant Adeno-Associated Virus for Efficient Gene Transfer to the Developing Mouse Inner Ear.

Gomes, Michelle M, Wang, Lingyan, Jiang, Han, Kahl, Christoph A, Brigande, John V · 2016 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: A Rapid, Cost-Effective Method to Prepare Recombinant Adeno-Associated Virus for Efficient Gene Transfer to the Developing Mouse Inner Ear.

Authors: Gomes, Michelle M, Wang, Lingyan, Jiang, Han, Kahl, Christoph A, Brigande, John V

Year: 2016

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-4939-3615-1_3

Paper Transcriptomic functional characterization of recombinant adeno-associated virus producing cell line adapted to suspension-growth.

Kuo, Han-Jung, Srinivasan, Prahalad, Lin, Yu-Chieh, Lu, Min, Rungkittikhun, Carissa, Zhang, Qi, Hu, Wei-Shou · 2025 · Biotechnology progress · DOI

Full title: Transcriptomic functional characterization of recombinant adeno-associated virus producing cell line adapted to suspension-growth.

Authors: Kuo, Han-Jung, Srinivasan, Prahalad, Lin, Yu-Chieh, Lu, Min, Rungkittikhun, Carissa, Zhang, Qi, Hu, Wei-Shou

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.70042

Paper Improved Genome Packaging Efficiency of Adeno-associated Virus Vectors Using Rep Hybrids.

Mietzsch, Mario, Eddington, Courtnee, Jose, Ariana, Hsi, Jane, Chipman, Paul, Henley, Tom, Choudhry, Modassir, McKenna, Robert, Agbandje-McKenna, Mavis · 2021 · Journal of virology · DOI

Full title: Improved Genome Packaging Efficiency of Adeno-associated Virus Vectors Using Rep Hybrids.

Authors: Mietzsch, Mario, Eddington, Courtnee, Jose, Ariana, Hsi, Jane, Chipman, Paul, Henley, Tom, Choudhry, Modassir, McKenna, Robert, Agbandje-McKenna, Mavis

Year: 2021

Venue: Journal of virology

DOI: https://doi.org/10.1128/JVI.00773-21

Paper [Expression of human tumor necrosis factor receptor-Fc fusion protein and characterization of its biological activity].

Du, Zhiyan, Wang, Fang, Zhu, Jingying, Yu, Jiyun, Wang, Yu, Zhu, Xiaoming, Zhang, Wei · 2014 · Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

Full title: [Expression of human tumor necrosis factor receptor-Fc fusion protein and characterization of its biological activity].

Authors: Du, Zhiyan, Wang, Fang, Zhu, Jingying, Yu, Jiyun, Wang, Yu, Zhu, Xiaoming, Zhang, Wei

Year: 2014

Venue: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

Paper AAV Vectors for Efficient Gene Delivery to Rodent Hearts.

Lopez-Gordo, Estrella, Kohlbrenner, Erik, Katz, Michael G, Weber, Thomas · 2019 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: AAV Vectors for Efficient Gene Delivery to Rodent Hearts.

Authors: Lopez-Gordo, Estrella, Kohlbrenner, Erik, Katz, Michael G, Weber, Thomas

Year: 2019

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-4939-9139-6_19

Paper Preclinical Development of an AAV8-hUGT1A1 Vector for the Treatment of Crigler-Najjar Syndrome.

Collaud, Fanny, Bortolussi, Giulia, Guianvarc'h, Laurence, Aronson, Sem J, Bordet, Thierry, Veron, Philippe, Charles, Severine, Vidal, Patrice, Sola, Marcelo Simon, Rundwasser, Stephanie, Dufour, Delphine G, Lacoste, Florence, Luc, Cyril, Wittenberghe, Laetitia V, Martin, Samia, Le Bec, Christine, Bosma, Piter J, Muro, Andres F, Ronzitti, Giuseppe, Hebben, Matthias, Mingozzi, Federico · 2019 · Molecular therapy. Methods & clinical development · DOI

Full title: Preclinical Development of an AAV8-hUGT1A1 Vector for the Treatment of Crigler-Najjar Syndrome.

Authors: Collaud, Fanny, Bortolussi, Giulia, Guianvarc'h, Laurence, Aronson, Sem J, Bordet, Thierry, Veron, Philippe, Charles, Severine, Vidal, Patrice, Sola, Marcelo Simon, Rundwasser, Stephanie, Dufour, Delphine G, Lacoste, Florence, Luc, Cyril, Wittenberghe, Laetitia V, Martin, Samia, Le Bec, Christine, Bosma, Piter J, Muro, Andres F, Ronzitti, Giuseppe, Hebben, Matthias, Mingozzi, Federico

Year: 2019

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2018.12.011

Paper Manufacturing of recombinant adeno-associated viruses using mammalian expression platforms.

Robert, Marc-André, Chahal, Parminder S, Audy, Alexandre, Kamen, Amine, Gilbert, Rénald, Gaillet, Bruno · 2017 · Biotechnology journal · DOI

Full title: Manufacturing of recombinant adeno-associated viruses using mammalian expression platforms.

Authors: Robert, Marc-André, Chahal, Parminder S, Audy, Alexandre, Kamen, Amine, Gilbert, Rénald, Gaillet, Bruno

Year: 2017

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201600193

Paper [A novel packaging system of recombinant AAV5/5 vector].

Dong, Xiaoyan, Tian, Wenhong, Yuan, Zhenhua, Tan, Shuping, Wu, Xiaobing · 2010 · Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Full title: [A novel packaging system of recombinant AAV5/5 vector].

Authors: Dong, Xiaoyan, Tian, Wenhong, Yuan, Zhenhua, Tan, Shuping, Wu, Xiaobing

Year: 2010

Venue: Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Paper ONLY A SMALL FRACTION OF CELLS PRODUCE ASSEMBLED CAPSIDS DURING TRANSFECTION-BASED MANUFACTURING OF ADENO-ASSOCIATED VIRUS VECTORS

Dash, Shantoshini, Sharon, David, Mullick, Alaka, Kamen, Amine · 2021 · DOI

Full title: ONLY A SMALL FRACTION OF CELLS PRODUCE ASSEMBLED CAPSIDS DURING TRANSFECTION-BASED MANUFACTURING OF ADENO-ASSOCIATED VIRUS VECTORS

Authors: Dash, Shantoshini, Sharon, David, Mullick, Alaka, Kamen, Amine

Year: 2021

DOI: https://doi.org/10.22541/au.163687913.34133715/v1

Paper Recombinant AAV genome size effect on viral vector production, purification, and thermostability.

Ibreljic, Nermin, Draper, Benjamin E, Lawton, Carl W · 2024 · Molecular therapy. Methods & clinical development · DOI

Full title: Recombinant AAV genome size effect on viral vector production, purification, and thermostability.

Authors: Ibreljic, Nermin, Draper, Benjamin E, Lawton, Carl W

Year: 2024

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2024.101188

Paper The Unveiled Novel regulator of Adeno-associated virus production in HEK293 cells.

Yan, Junyu, Li, Ziqian, Shu, Yue, Chen, Hui, Wang, Tianxingzi, Li, Xin, Zhang, Yuhang, Li, LiLi, Zhang, Yuntao · 2025 · Gene · DOI

Full title: The Unveiled Novel regulator of Adeno-associated virus production in HEK293 cells.

Authors: Yan, Junyu, Li, Ziqian, Shu, Yue, Chen, Hui, Wang, Tianxingzi, Li, Xin, Zhang, Yuhang, Li, LiLi, Zhang, Yuntao

Year: 2025

Venue: Gene

DOI: https://doi.org/10.1016/j.gene.2024.149122

Paper Gene Transfer of ZMapp Antibodies Mediated by Recombinant Adeno-Associated Virus Protects Against Ebola Infections.

Robert, Marc-André, Nassoury, Nasha, Chahal, Parminder S, Venne, Marie-Hélène, Racine, Trina, Qiu, Xiangguo, Kobinger, Gary, Kamen, Amine, Gilbert, Rénald, Gaillet, Bruno · 2018 · Human gene therapy · DOI

Full title: Gene Transfer of ZMapp Antibodies Mediated by Recombinant Adeno-Associated Virus Protects Against Ebola Infections.

Authors: Robert, Marc-André, Nassoury, Nasha, Chahal, Parminder S, Venne, Marie-Hélène, Racine, Trina, Qiu, Xiangguo, Kobinger, Gary, Kamen, Amine, Gilbert, Rénald, Gaillet, Bruno

Year: 2018

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2017.101

Paper Detailed Protocol for the Novel and Scalable Viral Vector Upstream Process for AAV Gene Therapy Manufacturing.

Selvaraj, Nagarathinam, Wang, Chao-Kuei, Bowser, Brian, Broadt, Trevor, Shaban, Samir, Burns, Jenna, Saptharishi, Nirmala, Pechan, Peter, Golebiowski, Diane, Alimardanov, Asaf, Yang, Nora, Mitra, George, Vepachedu, Ramarao · 2021 · Human gene therapy · DOI

Full title: Detailed Protocol for the Novel and Scalable Viral Vector Upstream Process for AAV Gene Therapy Manufacturing.

Authors: Selvaraj, Nagarathinam, Wang, Chao-Kuei, Bowser, Brian, Broadt, Trevor, Shaban, Samir, Burns, Jenna, Saptharishi, Nirmala, Pechan, Peter, Golebiowski, Diane, Alimardanov, Asaf, Yang, Nora, Mitra, George, Vepachedu, Ramarao

Year: 2021

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2020.054

Paper [Specific antitumor effect of adeno-associated virus vector carrying TRAIL gene under the control of hTERT promoter].

Qi, Rong, Cai, Ying, Li, Bing-Hua, Lin, Zhi-Xin, Gu, Jin-Fa · 2008 · Ai zheng = Aizheng = Chinese journal of cancer

Full title: [Specific antitumor effect of adeno-associated virus vector carrying TRAIL gene under the control of hTERT promoter].

Authors: Qi, Rong, Cai, Ying, Li, Bing-Hua, Lin, Zhi-Xin, Gu, Jin-Fa

Year: 2008

Venue: Ai zheng = Aizheng = Chinese journal of cancer

Paper Exploring the design space of AAV transient-transfection in suspension cell lines.

Meade, Oliver, Clark, Jeffrey, McCutchen, Michael, Kerwin, John · 2021 · Methods in enzymology · DOI

Full title: Exploring the design space of AAV transient-transfection in suspension cell lines.

Authors: Meade, Oliver, Clark, Jeffrey, McCutchen, Michael, Kerwin, John

Year: 2021

Venue: Methods in enzymology

DOI: https://doi.org/10.1016/bs.mie.2021.08.003

Paper Suppression of CNS APOE4 Expression by miRNAs Delivered by the S2 AAVrh.10 Capsid-Modified AAV Vector.

Karan, Kalpita R, Andrzejewski, Slawomir, Stiles, Katie M, Hackett, Neil R, Crystal, Ronald G · 2024 · Human gene therapy · DOI

Full title: Suppression of CNS APOE4 Expression by miRNAs Delivered by the S2 AAVrh.10 Capsid-Modified AAV Vector.

Authors: Karan, Kalpita R, Andrzejewski, Slawomir, Stiles, Katie M, Hackett, Neil R, Crystal, Ronald G

Year: 2024

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2024.112

Paper Engineering of High-Yield Recombinant Adeno-Associated Virus Producer Plasmids.

Radukic, Marco T, Le, Dinh To, Freudenberg, Robert, Hammann, Anne, Hamdan, Omar, Rothschild-Gronau, Claire, Hoffrogge, Raimund, Golm, Susanne K, Feiner, Rebecca C, Teschner, Kathrin E, Müller, Kristian M · 2026 · Biotechnology journal · DOI

Full title: Engineering of High-Yield Recombinant Adeno-Associated Virus Producer Plasmids.

Authors: Radukic, Marco T, Le, Dinh To, Freudenberg, Robert, Hammann, Anne, Hamdan, Omar, Rothschild-Gronau, Claire, Hoffrogge, Raimund, Golm, Susanne K, Feiner, Rebecca C, Teschner, Kathrin E, Müller, Kristian M

Year: 2026

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.70179

Paper Production of adeno-associated viral vector serotype 6 by triple transfection of suspension HEK293 cells at higher cell densities.

Moço, Pablo D, Xu, Xingge, Silva, Cristina A T, Kamen, Amine A · 2023 · Biotechnology journal · DOI

Full title: Production of adeno-associated viral vector serotype 6 by triple transfection of suspension HEK293 cells at higher cell densities.

Authors: Moço, Pablo D, Xu, Xingge, Silva, Cristina A T, Kamen, Amine A

Year: 2023

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202300051

Paper Small interfering RNA-mediated knockdown of chicken interferon-γ expression.

Haq, Kamran, Wootton, Sarah K, Barjesteh, Neda, St Paul, Michael, Golovan, Serguei, Bendall, Andrew J, Sharif, Shayan · 2013 · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · DOI

Full title: Small interfering RNA-mediated knockdown of chicken interferon-γ expression.

Authors: Haq, Kamran, Wootton, Sarah K, Barjesteh, Neda, St Paul, Michael, Golovan, Serguei, Bendall, Andrew J, Sharif, Shayan

Year: 2013

Venue: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

DOI: https://doi.org/10.1089/jir.2012.0141

Paper Production of Recombinant Adeno-associated Virus Vectors Using Suspension HEK293 Cells and Continuous Harvest of Vector From the Culture Media for GMP FIX and FLT1 Clinical Vector.

Grieger, Joshua C, Soltys, Stephen M, Samulski, Richard Jude · 2016 · Molecular therapy : the journal of the American Society of Gene Therapy · DOI

Full title: Production of Recombinant Adeno-associated Virus Vectors Using Suspension HEK293 Cells and Continuous Harvest of Vector From the Culture Media for GMP FIX and FLT1 Clinical Vector.

Authors: Grieger, Joshua C, Soltys, Stephen M, Samulski, Richard Jude

Year: 2016

Venue: Molecular therapy : the journal of the American Society of Gene Therapy

DOI: https://doi.org/10.1038/mt.2015.187

Paper A feasibility study of different commercially available serum-free mediums to enhance lentivirus and adeno-associated virus production in HEK 293 suspension cells.

Celebi Torabfam, Gizem, Yetisgin, Abuzer Alp, Erdem, Cem, Cayli, Aziz, Kutlu, Ozlem, Cetinel, Sibel · 2022 · Cytotechnology · DOI

Full title: A feasibility study of different commercially available serum-free mediums to enhance lentivirus and adeno-associated virus production in HEK 293 suspension cells.

Authors: Celebi Torabfam, Gizem, Yetisgin, Abuzer Alp, Erdem, Cem, Cayli, Aziz, Kutlu, Ozlem, Cetinel, Sibel

Year: 2022

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-022-00551-1

Paper Transfection and DNA-mediated gene transfer.

Zecchin, Davide, Di Nicolantonio, Federica · 2011 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Transfection and DNA-mediated gene transfer.

Authors: Zecchin, Davide, Di Nicolantonio, Federica

Year: 2011

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-61779-080-5_35

Paper Expression of Viral DNA Polymerase in Synthetic Recombinant Adeno-Associated Virus Producer Cell Line Enhances Full Particle Productivity.

Lin, Yu-Chieh, Kuo, Han-Jung, Lu, Min, Rungkittikhun, Carissa, Hu, Wei-Shou · 2025 · Biotechnology and bioengineering · DOI

Full title: Expression of Viral DNA Polymerase in Synthetic Recombinant Adeno-Associated Virus Producer Cell Line Enhances Full Particle Productivity.

Authors: Lin, Yu-Chieh, Kuo, Han-Jung, Lu, Min, Rungkittikhun, Carissa, Hu, Wei-Shou

Year: 2025

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28885

Paper Affecting HEK293 Cell Growth and Production Performance by Modifying the Expression of Specific Genes

Abaandou, Laura, Quan, David N., Shiloach, Joseph · 2021 · Cells · DOI

Full title: Affecting HEK293 Cell Growth and Production Performance by Modifying the Expression of Specific Genes

Authors: Abaandou, Laura, Quan, David N., Shiloach, Joseph

Year: 2021

Venue: Cells

DOI: https://doi.org/10.3390/cells10071667

Paper Host cells and cell banking.

Stacey, Glyn N, Merten, Otto-Wilhelm · 2011 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Host cells and cell banking.

Authors: Stacey, Glyn N, Merten, Otto-Wilhelm

Year: 2011

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-61779-095-9_3

Paper AAV Production Everywhere: A Simple, Fast, and Reliable Protocol for In-house AAV Vector Production Based on Chloroform Extraction.

Negrini, Matilde, Wang, Gang, Heuer, Andreas, Björklund, Tomas, Davidsson, Marcus · 2020 · Current protocols in neuroscience · DOI

Full title: AAV Production Everywhere: A Simple, Fast, and Reliable Protocol for In-house AAV Vector Production Based on Chloroform Extraction.

Authors: Negrini, Matilde, Wang, Gang, Heuer, Andreas, Björklund, Tomas, Davidsson, Marcus

Year: 2020

Venue: Current protocols in neuroscience

DOI: https://doi.org/10.1002/cpns.103

Paper Noninvasive focused ultrasound-mediated delivery of rAAV9-EGFP vectors for neuronal targeting in rats.

Wang, Rui, Li, Jiayi · 2024 · NeuroImage · DOI

Full title: Noninvasive focused ultrasound-mediated delivery of rAAV9-EGFP vectors for neuronal targeting in rats.

Authors: Wang, Rui, Li, Jiayi

Year: 2024

Venue: NeuroImage

DOI: https://doi.org/10.1016/j.neuroimage.2024.120630

Paper A Direct Comparison of rAAV5 Variants Derived from the Baculovirus Expression System Using LC-MS Workflows Demonstrates Key Differences in Overall Production Yield, Product Quality and Vector Efficiency

Guapo, Felipe, Donohue, Nicholas, Strasser, Lisa, Boi, Stefano, Füssl, Florian, Rainbow-Fletcher, Alana, Getty, Paul M., Anderson, Ian, Barron, Niall, Bones, Jonathan · 2024 · International Journal of Molecular Sciences · DOI

Full title: A Direct Comparison of rAAV5 Variants Derived from the Baculovirus Expression System Using LC-MS Workflows Demonstrates Key Differences in Overall Production Yield, Product Quality and Vector Efficiency

Authors: Guapo, Felipe, Donohue, Nicholas, Strasser, Lisa, Boi, Stefano, Füssl, Florian, Rainbow-Fletcher, Alana, Getty, Paul M., Anderson, Ian, Barron, Niall, Bones, Jonathan

Year: 2024

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms25052785

Paper Different protein composition and functional properties of adeno-associated virus-6 vector manufactured from the culture medium and cell lysates.

Denard, Jerome, Jenny, Christine, Blouin, Véronique, Moullier, Philippe, Svinartchouk, Fedor · 2014 · Molecular therapy. Methods & clinical development · DOI

Full title: Different protein composition and functional properties of adeno-associated virus-6 vector manufactured from the culture medium and cell lysates.

Authors: Denard, Jerome, Jenny, Christine, Blouin, Véronique, Moullier, Philippe, Svinartchouk, Fedor

Year: 2014

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1038/mtm.2014.31

Paper Improvement in the suspension-culture production of recombinant adeno-associated virus-LacZ in HEK-293 cells using polyethyleneimine-DNA complexes in combination with hypothermic treatment.

Feng, Lei, Guo, Meijin, Zhang, Shuxiang, Chu, Ju, Zhuang, Yingping, Zhang, Siliang · 2008 · Biotechnology and applied biochemistry · DOI

Full title: Improvement in the suspension-culture production of recombinant adeno-associated virus-LacZ in HEK-293 cells using polyethyleneimine-DNA complexes in combination with hypothermic treatment.

Authors: Feng, Lei, Guo, Meijin, Zhang, Shuxiang, Chu, Ju, Zhuang, Yingping, Zhang, Siliang

Year: 2008

Venue: Biotechnology and applied biochemistry

DOI: https://doi.org/10.1042/BA20070081

Paper Knockout of Pro-Apoptotic BAX and BAK1 Genes in HEK293T Cells Enhances Adeno-Associated Virus (AAV) Production: AAV2 and AAV9.

Park, Sungje, Shin, Seunghyeon, Han, Gyucheol, Lee, Gyun Min · 2025 · Biotechnology journal · DOI

Full title: Knockout of Pro-Apoptotic BAX and BAK1 Genes in HEK293T Cells Enhances Adeno-Associated Virus (AAV) Production: AAV2 and AAV9.

Authors: Park, Sungje, Shin, Seunghyeon, Han, Gyucheol, Lee, Gyun Min

Year: 2025

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202400529

Paper Immunogenicity of an adeno-vector vaccine expressing the F protein of a respiratory syncytial virus manufactured from serum-free suspension culture.

Shao, Hsiao-Yun, Hsu, Huai-Sheng, Yu, Shu-Ling, Wu, Shang-Rung, Hu, Kai-Chieh, Chang, Ching-Kun, Liu, Chia-Chyi, Chow, Yen-Hung · 2016 · Antiviral research · DOI

Full title: Immunogenicity of an adeno-vector vaccine expressing the F protein of a respiratory syncytial virus manufactured from serum-free suspension culture.

Authors: Shao, Hsiao-Yun, Hsu, Huai-Sheng, Yu, Shu-Ling, Wu, Shang-Rung, Hu, Kai-Chieh, Chang, Ching-Kun, Liu, Chia-Chyi, Chow, Yen-Hung

Year: 2016

Venue: Antiviral research

DOI: https://doi.org/10.1016/j.antiviral.2016.03.011

Paper The HPV16 E1 Carboxyl Domain Provides a Helper Function for Adeno-Associated Virus Replication.

Cao, Maohua, Bandyopadhyay, Sarmistha, Zhu, Hongqing, You, Hong, Hermonat, Paul L · 2018 · Intervirology · DOI

Full title: The HPV16 E1 Carboxyl Domain Provides a Helper Function for Adeno-Associated Virus Replication.

Authors: Cao, Maohua, Bandyopadhyay, Sarmistha, Zhu, Hongqing, You, Hong, Hermonat, Paul L

Year: 2018

Venue: Intervirology

DOI: https://doi.org/10.1159/000495137

Paper Can novel bioreactors improve the cost of goods of viral vectors?

Stamatis, Christos, Chatel, Alex, Farid, Suzanne S. · 2023 · Cell and Gene Therapy Insights · DOI

Full title: Can novel bioreactors improve the cost of goods of viral vectors?

Authors: Stamatis, Christos, Chatel, Alex, Farid, Suzanne S.

Year: 2023

Venue: Cell and Gene Therapy Insights

DOI: https://doi.org/10.18609/cgti.2023.087

Paper rAAV Manufacturing: The Challenges of Soft Sensing during Upstream Processing

Iglesias, Cristovão Freitas, Ristovski, Miliça, Bolić, Miodrag, Čuperlović‐Culf, Miroslava · 2023 · Bioengineering · DOI

Full title: rAAV Manufacturing: The Challenges of Soft Sensing during Upstream Processing

Authors: Iglesias, Cristovão Freitas, Ristovski, Miliça, Bolić, Miodrag, Čuperlović‐Culf, Miroslava

Year: 2023

Venue: Bioengineering

DOI: https://doi.org/10.3390/bioengineering10020229

Paper Proteomic Landscape of Adeno-Associated Virus (AAV)-Producing HEK293 Cells.

Strasser, Lisa, Boi, Stefano, Guapo, Felipe, Donohue, Nicholas, Barron, Niall, Rainbow-Fletcher, Alana, Bones, Jonathan · 2021 · International journal of molecular sciences · DOI

Full title: Proteomic Landscape of Adeno-Associated Virus (AAV)-Producing HEK293 Cells.

Authors: Strasser, Lisa, Boi, Stefano, Guapo, Felipe, Donohue, Nicholas, Barron, Niall, Rainbow-Fletcher, Alana, Bones, Jonathan

Year: 2021

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms222111499

Paper Production of Recombinant Adeno-Associated Virus Through High-Cell-Density Transfection of HEK293 Cells Based on Fed-Perfusion Culture.

Deng, Zhe, Lv, Yan-Ling, Wang, Xin-Tao, Yuan, Long-Hui, Zhao, Kai, Du, Zeng-Min, Xiao, Xiao · 2025 · Human gene therapy · DOI

Full title: Production of Recombinant Adeno-Associated Virus Through High-Cell-Density Transfection of HEK293 Cells Based on Fed-Perfusion Culture.

Authors: Deng, Zhe, Lv, Yan-Ling, Wang, Xin-Tao, Yuan, Long-Hui, Zhao, Kai, Du, Zeng-Min, Xiao, Xiao

Year: 2025

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2024.160

Paper Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells.

Blessing, Daniel, Vachey, Gabriel, Pythoud, Catherine, Rey, Maria, Padrun, Vivianne, Wurm, Florian M, Schneider, Bernard L, Déglon, Nicole · 2019 · Molecular therapy. Methods & clinical development · DOI

Full title: Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells.

Authors: Blessing, Daniel, Vachey, Gabriel, Pythoud, Catherine, Rey, Maria, Padrun, Vivianne, Wurm, Florian M, Schneider, Bernard L, Déglon, Nicole

Year: 2019

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2018.11.004

Paper Restoration of cytoskeleton homeostasis after gigaxonin gene transfer for giant axonal neuropathy.

Mussche, Silke, Devreese, Bart, Nagabhushan Kalburgi, Sahana, Bachaboina, Lavanya, Fox, Jonathan C, Shih, Hung-Jui, Van Coster, Rudy, Samulski, R Jude, Gray, Steven J · 2013 · Human gene therapy · DOI

Full title: Restoration of cytoskeleton homeostasis after gigaxonin gene transfer for giant axonal neuropathy.

Authors: Mussche, Silke, Devreese, Bart, Nagabhushan Kalburgi, Sahana, Bachaboina, Lavanya, Fox, Jonathan C, Shih, Hung-Jui, Van Coster, Rudy, Samulski, R Jude, Gray, Steven J

Year: 2013

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2012.107

Paper Iterative hybrid model based optimization of rAAV production.

Müller, Claudio, Siegwart, Gerald, Heider, Susanne, Sokolov, Michael, Botros, Angela, Umprecht, Alexandra, von Stosch, Moritz, Cruz Bournazou, Mariano Nicolas · 2025 · Biotechnology progress · DOI

Full title: Iterative hybrid model based optimization of rAAV production.

Authors: Müller, Claudio, Siegwart, Gerald, Heider, Susanne, Sokolov, Michael, Botros, Angela, Umprecht, Alexandra, von Stosch, Moritz, Cruz Bournazou, Mariano Nicolas

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.70006

Paper Orthogonal characterization of rAAV9 reveals unexpected transgene heterogeneity.

Eisenhut, Peter, Andorfer, Peter, Haid, Andrea, Jokl, Beatrice, Manhartsberger, Raffaela, Fuchsberger, Felix, Innthaler, Bernd, Lengler, Johannes, Kraus, Barbara, Pletzenauer, Robert, Hernandez Bort, Juan A, Unterthurner, Sabine · 2024 · Journal of biotechnology · DOI

Full title: Orthogonal characterization of rAAV9 reveals unexpected transgene heterogeneity.

Authors: Eisenhut, Peter, Andorfer, Peter, Haid, Andrea, Jokl, Beatrice, Manhartsberger, Raffaela, Fuchsberger, Felix, Innthaler, Bernd, Lengler, Johannes, Kraus, Barbara, Pletzenauer, Robert, Hernandez Bort, Juan A, Unterthurner, Sabine

Year: 2024

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2024.07.020

Paper [Construction and expression of non-structural protein gene 3-4b of HCV 1b based on the adenoassociated virus vector].

Chen, Tian, Sun, Hai-Xia, Qin, Wei-Bin, Zhu, Feng-Qin, Li, Xue-Ling, Cao, Hong, Xu, Qi-Huan, Li, Gang · 2013 · Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology

Full title: [Construction and expression of non-structural protein gene 3-4b of HCV 1b based on the adenoassociated virus vector].

Authors: Chen, Tian, Sun, Hai-Xia, Qin, Wei-Bin, Zhu, Feng-Qin, Li, Xue-Ling, Cao, Hong, Xu, Qi-Huan, Li, Gang

Year: 2013

Venue: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology

Paper Faculty Opinions recommendation of Adeno-associated virus vector as a platform for gene therapy delivery.

Fehlings, Michael G. · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · DOI

Full title: Faculty Opinions recommendation of Adeno-associated virus vector as a platform for gene therapy delivery.

Authors: Fehlings, Michael G.

Year: 2020

Venue: Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI: https://doi.org/10.3410/f.734958350.793573257

Paper Multidose transient transfection of human embryonic kidney 293 cells modulates recombinant adeno-associated virus2/5 Rep protein expression and influences the enrichment fraction of filled capsids.

Srinivasan, Prasanna, Canova, Christopher T, Sha, Sha, Nguyen, Tam N T, Joseph, John, Sangerman, Jose, Maloney, Andrew J, Katsikis, Georgios, Ou, Rui Wen, Hong, Moo Sun, Ng, Jaclyn, Yuan, Arella, Antov, Daniel, Song, Sally, Chen, Wenyu, Neufeld, Caleb, Wolfrum, Jacqueline M, Barone, Paul W, Sinskey, Anthony J, Springs, Stacy L, Braatz, Richard D · 2024 · Biotechnology and bioengineering · DOI

Full title: Multidose transient transfection of human embryonic kidney 293 cells modulates recombinant adeno-associated virus2/5 Rep protein expression and influences the enrichment fraction of filled capsids.

Authors: Srinivasan, Prasanna, Canova, Christopher T, Sha, Sha, Nguyen, Tam N T, Joseph, John, Sangerman, Jose, Maloney, Andrew J, Katsikis, Georgios, Ou, Rui Wen, Hong, Moo Sun, Ng, Jaclyn, Yuan, Arella, Antov, Daniel, Song, Sally, Chen, Wenyu, Neufeld, Caleb, Wolfrum, Jacqueline M, Barone, Paul W, Sinskey, Anthony J, Springs, Stacy L, Braatz, Richard D

Year: 2024

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28828

Paper Bioreducible polycationic gene vectors

Gao, Si · 2015 · DOI

Full title: Bioreducible polycationic gene vectors

Authors: Gao, Si

Year: 2015

DOI: https://doi.org/10.3990/1.9789036540407

Paper Production and Characterization of Vectors Based on the Cardiotropic AAV Serotype 9.

Kohlbrenner, Erik, Weber, Thomas · 2017 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Production and Characterization of Vectors Based on the Cardiotropic AAV Serotype 9.

Authors: Kohlbrenner, Erik, Weber, Thomas

Year: 2017

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-4939-6588-5_6

Paper Adeno-Associated Virus Vector Mobilization, Risk Versus Reality

Song, Liujiang, Samulski, R. Jude, Hirsch, Matthew L. · 2020 · Human Gene Therapy · DOI

Full title: Adeno-Associated Virus Vector Mobilization, Risk Versus Reality

Authors: Song, Liujiang, Samulski, R. Jude, Hirsch, Matthew L.

Year: 2020

Venue: Human Gene Therapy

DOI: https://doi.org/10.1089/hum.2020.118

Paper Bacteriophage Mediates Efficient Gene Transfer in Combination with Conventional Transfection Reagents

Donnelly, Amanda, Yata, Teerapong, Bentayebi, Kaoutar, Suwan, Keittisak, Hajitou, Amin · 2015 · Viruses · DOI

Full title: Bacteriophage Mediates Efficient Gene Transfer in Combination with Conventional Transfection Reagents

Authors: Donnelly, Amanda, Yata, Teerapong, Bentayebi, Kaoutar, Suwan, Keittisak, Hajitou, Amin

Year: 2015

Venue: Viruses

DOI: https://doi.org/10.3390/v7122951

Paper Production of rVSV-ZEBOV in serum-free suspension culture of HEK 293SF cells

Gélinas, Jean‐François, Azizi, Hiva, Kießlich, Sascha, Lanthier, Stéphane, Perdersen, Jannie, Chahal, Parminder S., Ansorge, Sven, Kobinger, Gary, Gilbert, Rénald, Kamen, Amine · 2019 · Vaccine · DOI

Full title: Production of rVSV-ZEBOV in serum-free suspension culture of HEK 293SF cells

Authors: Gélinas, Jean‐François, Azizi, Hiva, Kießlich, Sascha, Lanthier, Stéphane, Perdersen, Jannie, Chahal, Parminder S., Ansorge, Sven, Kobinger, Gary, Gilbert, Rénald, Kamen, Amine

Year: 2019

Venue: Vaccine

DOI: https://doi.org/10.1016/j.vaccine.2019.09.044

Paper Systematic comparison of rAAV vectors manufactured using large-scale suspension cultures of Sf9 and HEK293 cells.

Liu, Shengjiang, Li, Jinzhong, Peraramelli, Sameera, Luo, Ningguang, Chen, Alan, Dai, Minghua, Liu, Fang, Yu, Yanbao, Leib, Ryan D, Li, Ying, Lin, Kevin, Huynh, Derrick, Li, Shuyi, Ou, Li · 2024 · Molecular therapy : the journal of the American Society of Gene Therapy · DOI

Full title: Systematic comparison of rAAV vectors manufactured using large-scale suspension cultures of Sf9 and HEK293 cells.

Authors: Liu, Shengjiang, Li, Jinzhong, Peraramelli, Sameera, Luo, Ningguang, Chen, Alan, Dai, Minghua, Liu, Fang, Yu, Yanbao, Leib, Ryan D, Li, Ying, Lin, Kevin, Huynh, Derrick, Li, Shuyi, Ou, Li

Year: 2024

Venue: Molecular therapy : the journal of the American Society of Gene Therapy

DOI: https://doi.org/10.1016/j.ymthe.2023.11.022

Paper Integration of adeno-associated virus-derived peptides into nonviral vectors to synergistically enhance cellular transfection.

Kim, Jung-Suk, Kim, Eunmi, Oh, Ji-Seon, Jang, Jae-Hyung · 2013 · Biomacromolecules · DOI

Full title: Integration of adeno-associated virus-derived peptides into nonviral vectors to synergistically enhance cellular transfection.

Authors: Kim, Jung-Suk, Kim, Eunmi, Oh, Ji-Seon, Jang, Jae-Hyung

Year: 2013

Venue: Biomacromolecules

DOI: https://doi.org/10.1021/bm4005854

Paper [Resistance of rAAV2-MfE77.43-Transferred Mice to Schistosoma japonicum Infection].

Wang, Hong-mei, Xiong, De-hui, Luo, Sai-qun, Yang, Jie, Qian, Yin-jun, Qin, Zhi-qiang · 2016 · Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases

Full title: [Resistance of rAAV2-MfE77.43-Transferred Mice to Schistosoma japonicum Infection].

Authors: Wang, Hong-mei, Xiong, De-hui, Luo, Sai-qun, Yang, Jie, Qian, Yin-jun, Qin, Zhi-qiang

Year: 2016

Venue: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases

Paper Development of Stable Packaging and Producer Cell Lines for the Production of AAV Vectors.

Merten, Otto-Wilhelm · 2024 · Microorganisms · DOI

Full title: Development of Stable Packaging and Producer Cell Lines for the Production of AAV Vectors.

Authors: Merten, Otto-Wilhelm

Year: 2024

Venue: Microorganisms

DOI: https://doi.org/10.3390/microorganisms12020384

Paper Characterization of a spontaneously generated murine retinal pigmented epithelium cell line; a model for in vitro experiments.

Ranaei Pirmardan, Ehsan, Soheili, Zahra-Soheila, Samiei, Shahram, Ahmadieh, Hamid, Mowla, Seyed Javad, Ezzati, Razie, Naseri, Marzieh · 2016 · Experimental cell research · DOI

Full title: Characterization of a spontaneously generated murine retinal pigmented epithelium cell line; a model for in vitro experiments.

Authors: Ranaei Pirmardan, Ehsan, Soheili, Zahra-Soheila, Samiei, Shahram, Ahmadieh, Hamid, Mowla, Seyed Javad, Ezzati, Razie, Naseri, Marzieh

Year: 2016

Venue: Experimental cell research

DOI: https://doi.org/10.1016/j.yexcr.2016.08.015

Paper Copackaging of multiple adeno-associated viral vectors in a single production step.

Doerfler, Phillip A, Byrne, Barry J, Clément, Nathalie · 2014 · Human gene therapy methods · DOI

Full title: Copackaging of multiple adeno-associated viral vectors in a single production step.

Authors: Doerfler, Phillip A, Byrne, Barry J, Clément, Nathalie

Year: 2014

Venue: Human gene therapy methods

DOI: https://doi.org/10.1089/hgtb.2014.055

Paper Increased recombinant AAV production by HEK293 cells using small molecule chemical additives

Scarrott, Joseph M., Johari, Yusuf B., Pohle, Thilo H., Liu, Ping, Mayer, Ayda, James, David A. · 2022 · DOI

Full title: Increased recombinant AAV production by HEK293 cells using small molecule chemical additives

Authors: Scarrott, Joseph M., Johari, Yusuf B., Pohle, Thilo H., Liu, Ping, Mayer, Ayda, James, David A.

Year: 2022

DOI: https://doi.org/10.22541/au.166051625.50657820/v1

Paper Purification of Adeno-Associated Virus (AAV) Serotype 2 from Spodoptera frugiperda (Sf9) Lysate by Chromatographic Nonwoven Membranes

Fan, Jinxin, Barbieri, Eduardo, Shastry, Shriarjun, Menegatti, Stefano, Boi, Cristiana, Carbonell, Ruben G. · 2022 · Membranes · DOI

Full title: Purification of Adeno-Associated Virus (AAV) Serotype 2 from Spodoptera frugiperda (Sf9) Lysate by Chromatographic Nonwoven Membranes

Authors: Fan, Jinxin, Barbieri, Eduardo, Shastry, Shriarjun, Menegatti, Stefano, Boi, Cristiana, Carbonell, Ruben G.

Year: 2022

Venue: Membranes

DOI: https://doi.org/10.3390/membranes12100944

Paper [Construction and identification of recombinant adeno-associated virus shuttle vector expressing nerve growth factor beta gene].

Li, Ruofei, Gao, Dalong, Dang, Xiaoqian, Wang, Kunzheng, Yang, Leigang, Tu, Zhongmin · 2012 · Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

Full title: [Construction and identification of recombinant adeno-associated virus shuttle vector expressing nerve growth factor beta gene].

Authors: Li, Ruofei, Gao, Dalong, Dang, Xiaoqian, Wang, Kunzheng, Yang, Leigang, Tu, Zhongmin

Year: 2012

Venue: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

Paper Engineered AAV2.7m8 Serotype Shows Significantly Higher Transduction Efficiency of ARPE-19 and HEK293 Cell Lines Compared to AAV5, AAV8 and AAV9 Serotypes

Gurtsieva, Dzerassa, Minskaia, Ekaterina, Zhuravleva, Sofia, Субчева, Е. Н., Sakhibgaraeva, Elena, Brovin, Andrew, Tumaev, Artem, Karabelsky, Alexander · 2024 · Pharmaceutics · DOI

Full title: Engineered AAV2.7m8 Serotype Shows Significantly Higher Transduction Efficiency of ARPE-19 and HEK293 Cell Lines Compared to AAV5, AAV8 and AAV9 Serotypes

Authors: Gurtsieva, Dzerassa, Minskaia, Ekaterina, Zhuravleva, Sofia, Субчева, Е. Н., Sakhibgaraeva, Elena, Brovin, Andrew, Tumaev, Artem, Karabelsky, Alexander

Year: 2024

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics16010138

Paper Efficient production of an avian adeno-associated virus vector using insect cell/baculovirus expression system.

Wang, Anping, Wang, Yongjuan, Wu, Shuang, Zuo, Weiyong, Guo, Changming, Hong, Weiming, Zhu, Shanyuan · 2017 · Journal of virological methods · DOI

Full title: Efficient production of an avian adeno-associated virus vector using insect cell/baculovirus expression system.

Authors: Wang, Anping, Wang, Yongjuan, Wu, Shuang, Zuo, Weiyong, Guo, Changming, Hong, Weiming, Zhu, Shanyuan

Year: 2017

Venue: Journal of virological methods

DOI: https://doi.org/10.1016/j.jviromet.2016.11.005

Paper [Expression of TRAIL(114-281) mediated by adeno-associated virus and its tumoricidal activity].

Ma, Hong, Liu, Yan-Xin, Liu, Shi-Lian, Xu, Rui-An, Zheng, De-Xian · 2004 · Zhonghua yi xue za zhi

Full title: [Expression of TRAIL(114-281) mediated by adeno-associated virus and its tumoricidal activity].

Authors: Ma, Hong, Liu, Yan-Xin, Liu, Shi-Lian, Xu, Rui-An, Zheng, De-Xian

Year: 2004

Venue: Zhonghua yi xue za zhi

Paper Bioengineered Hybrid Rep 2/6 Gene Improves Encapsulation of a Single-Stranded Expression Cassette into AAV6 Vectors

Tejero, Marcos, Duzenli, Ozgun F., Caine, Colin, Kuoch, Hisae, Aslanidi, George · 2023 · Genes · DOI

Full title: Bioengineered Hybrid Rep 2/6 Gene Improves Encapsulation of a Single-Stranded Expression Cassette into AAV6 Vectors

Authors: Tejero, Marcos, Duzenli, Ozgun F., Caine, Colin, Kuoch, Hisae, Aslanidi, George

Year: 2023

Venue: Genes

DOI: https://doi.org/10.3390/genes14101866

Paper Adeno-Associated Virus Production in Serum-Free Suspension Adapted HEK293 Cells for Gene Therapy.

Ijeomah, Brenda Ijeoma · 2019 · NCSU Libraries Repository (North Carolina State University Libraries)

Full title: Adeno-Associated Virus Production in Serum-Free Suspension Adapted HEK293 Cells for Gene Therapy.

Authors: Ijeomah, Brenda Ijeoma

Year: 2019

Venue: NCSU Libraries Repository (North Carolina State University Libraries)

Paper Enhanced AAV production via rational design of a novel pHelper vector integrated with HSV-1 helper genes.

Ren, He, Nie, Jianqi, Song, Zichuan, Mo, Wanting, Yang, Yankun, Bai, Zhonghu · 2026 · Synthetic and systems biotechnology · DOI

Full title: Enhanced AAV production via rational design of a novel pHelper vector integrated with HSV-1 helper genes.

Authors: Ren, He, Nie, Jianqi, Song, Zichuan, Mo, Wanting, Yang, Yankun, Bai, Zhonghu

Year: 2026

Venue: Synthetic and systems biotechnology

DOI: https://doi.org/10.1016/j.synbio.2025.12.018

Paper Optimization of transfection mediated by calcium phosphate for plasmid rAAV-LacZ (recombinant adeno-associated virus-beta-galactosidase reporter gene) production in suspension-cultured HEK-293 (human embryonic kidney 293) cells.

Feng, Lei, Guo, Meijin, Zhang, Shuxiang, Chu, Ju, Zhuang, Yingping, Zhang, Siliang · 2007 · Biotechnology and applied biochemistry · DOI

Full title: Optimization of transfection mediated by calcium phosphate for plasmid rAAV-LacZ (recombinant adeno-associated virus-beta-galactosidase reporter gene) production in suspension-cultured HEK-293 (human embryonic kidney 293) cells.

Authors: Feng, Lei, Guo, Meijin, Zhang, Shuxiang, Chu, Ju, Zhuang, Yingping, Zhang, Siliang

Year: 2007

Venue: Biotechnology and applied biochemistry

DOI: https://doi.org/10.1042/BA20060143

Paper The use of melittin to enhance transgene expression mediated by recombinant adeno-associated virus serotype 2 vectors both in vitro and in vivo.

Xie, Yi-Lin, Wang, Ji-Yao, He, Yun, Yu, Xiao-Min, Zheng, Qing-Yun, Ling, Chen, Feng, Xi-Lin, Zhu, Li-Qing · 2023 · Journal of integrative medicine · DOI

Full title: The use of melittin to enhance transgene expression mediated by recombinant adeno-associated virus serotype 2 vectors both in vitro and in vivo.

Authors: Xie, Yi-Lin, Wang, Ji-Yao, He, Yun, Yu, Xiao-Min, Zheng, Qing-Yun, Ling, Chen, Feng, Xi-Lin, Zhu, Li-Qing

Year: 2023

Venue: Journal of integrative medicine

DOI: https://doi.org/10.1016/j.joim.2022.10.003

Paper Corticospinal tract transduction: a comparison of seven adeno-associated viral vector serotypes and a non-integrating lentiviral vector.

Hutson, T H, Verhaagen, J, Yáñez-Muñoz, R J, Moon, L D F · 2012 · Gene therapy · DOI

Full title: Corticospinal tract transduction: a comparison of seven adeno-associated viral vector serotypes and a non-integrating lentiviral vector.

Authors: Hutson, T H, Verhaagen, J, Yáñez-Muñoz, R J, Moon, L D F

Year: 2012

Venue: Gene therapy

DOI: https://doi.org/10.1038/gt.2011.71

Paper Real-Time VCC Monitoring and Forecasting in HEK-Cell-Based rAAV Vector Production Using Capacitance Spectroscopy.

Machleid, Rafael, Nunna, Suneetha, George, Ajith, Austerjost, Jonas, Tomala, Magda, Surowiec, Izabella · 2025 · Engineering in life sciences · DOI

Full title: Real-Time VCC Monitoring and Forecasting in HEK-Cell-Based rAAV Vector Production Using Capacitance Spectroscopy.

Authors: Machleid, Rafael, Nunna, Suneetha, George, Ajith, Austerjost, Jonas, Tomala, Magda, Surowiec, Izabella

Year: 2025

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.70004

Paper An efficient rHSV-based complementation system for the production of multiple rAAV vector serotypes.

Kang, W, Wang, L, Harrell, H, Liu, J, Thomas, D L, Mayfield, T L, Scotti, M M, Ye, G J, Veres, G, Knop, D R · 2009 · Gene therapy · DOI

Full title: An efficient rHSV-based complementation system for the production of multiple rAAV vector serotypes.

Authors: Kang, W, Wang, L, Harrell, H, Liu, J, Thomas, D L, Mayfield, T L, Scotti, M M, Ye, G J, Veres, G, Knop, D R

Year: 2009

Venue: Gene therapy

DOI: https://doi.org/10.1038/gt.2008.158

Paper Dielectric Spectroscopy to Improve the Production of rAAV Used in Gene Therapy

Pais, Daniel A. M., Brown, Chris W., Neuman, Anastasia, Mathur, Krishanu, Isidro, Inês A., Alves, Paula M., Slade, Peter G. · 2020 · Processes · DOI

Full title: Dielectric Spectroscopy to Improve the Production of rAAV Used in Gene Therapy

Authors: Pais, Daniel A. M., Brown, Chris W., Neuman, Anastasia, Mathur, Krishanu, Isidro, Inês A., Alves, Paula M., Slade, Peter G.

Year: 2020

Venue: Processes

DOI: https://doi.org/10.3390/pr8111456

Paper Improving viral-based gene delivery to mammalian cells through simple co-incubation with transportan peptide in vitro.

Wang, Nianwu, Hu, Xiangxiang, Pang, Hong-Bo · 2025 · Journal of pharmaceutical sciences · DOI

Full title: Improving viral-based gene delivery to mammalian cells through simple co-incubation with transportan peptide in vitro.

Authors: Wang, Nianwu, Hu, Xiangxiang, Pang, Hong-Bo

Year: 2025

Venue: Journal of pharmaceutical sciences

DOI: https://doi.org/10.1016/j.xphs.2025.103920

Paper Dynamic imaging of pancreatic nuclear factor κB (NF-κB) activation in live mice using adeno-associated virus (AAV) infusion and bioluminescence.

Orabi, Abrahim I, Sah, Swati, Javed, Tanveer A, Lemon, Kathryn L, Good, Misty L, Guo, Ping, Xiao, Xiangwei, Prasadan, Krishna, Gittes, George K, Jin, Shunqian, Husain, Sohail Z · 2015 · The Journal of biological chemistry · DOI

Full title: Dynamic imaging of pancreatic nuclear factor κB (NF-κB) activation in live mice using adeno-associated virus (AAV) infusion and bioluminescence.

Authors: Orabi, Abrahim I, Sah, Swati, Javed, Tanveer A, Lemon, Kathryn L, Good, Misty L, Guo, Ping, Xiao, Xiangwei, Prasadan, Krishna, Gittes, George K, Jin, Shunqian, Husain, Sohail Z

Year: 2015

Venue: The Journal of biological chemistry

DOI: https://doi.org/10.1074/jbc.M115.647933

Paper Multi-omics driven genome-scale metabolic modeling improves viral vector yield in HEK293.

Zehetner, L, Széliová, D, Kraus, B, Hernandez Bort, J A, Zanghellini, J · 2025 · Metabolic engineering · DOI

Full title: Multi-omics driven genome-scale metabolic modeling improves viral vector yield in HEK293.

Authors: Zehetner, L, Széliová, D, Kraus, B, Hernandez Bort, J A, Zanghellini, J

Year: 2025

Venue: Metabolic engineering

DOI: https://doi.org/10.1016/j.ymben.2025.03.011

Paper Protocol for Efficient Generation and Characterization of Adeno-Associated Viral Vectors.

Jungmann, Andreas, Leuchs, Barbara, Rommelaere, Jean, Katus, Hugo A, Müller, Oliver J · 2017 · Human gene therapy methods · DOI

Full title: Protocol for Efficient Generation and Characterization of Adeno-Associated Viral Vectors.

Authors: Jungmann, Andreas, Leuchs, Barbara, Rommelaere, Jean, Katus, Hugo A, Müller, Oliver J

Year: 2017

Venue: Human gene therapy methods

DOI: https://doi.org/10.1089/hgtb.2017.192

Paper Using Adeno-associated Virus as a Tool to Study Retinal Barriers in Disease.

Vacca, Ophélie, El Mathari, Brahim, Darche, Marie, Sahel, José-Alain, Rendon, Alvaro, Dalkara, Deniz · 2015 · Journal of visualized experiments : JoVE · DOI

Full title: Using Adeno-associated Virus as a Tool to Study Retinal Barriers in Disease.

Authors: Vacca, Ophélie, El Mathari, Brahim, Darche, Marie, Sahel, José-Alain, Rendon, Alvaro, Dalkara, Deniz

Year: 2015

Venue: Journal of visualized experiments : JoVE

DOI: https://doi.org/10.3791/52451

Paper Development and Optimization of AAV hFIX Particles by Transient Transfection in an iCELLis(®) Fixed-Bed Bioreactor.

Powers, Alicia D, Piras, Bryan A, Clark, Robert K, Lockey, Timothy D, Meagher, Michael M · 2016 · Human gene therapy methods · DOI

Full title: Development and Optimization of AAV hFIX Particles by Transient Transfection in an iCELLis(®) Fixed-Bed Bioreactor.

Authors: Powers, Alicia D, Piras, Bryan A, Clark, Robert K, Lockey, Timothy D, Meagher, Michael M

Year: 2016

Venue: Human gene therapy methods

DOI: https://doi.org/10.1089/hgtb.2016.021

Paper [Optimized AAV package and experimental application of recombinant AAV8/hFⅧ for gene therapy on hemophilia A mice].

Mao, J H, Shen, Y, Wang, Q, Wang, Y, Ruan, Z, Xi, X D · 2020 · Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · DOI

Full title: [Optimized AAV package and experimental application of recombinant AAV8/hFⅧ for gene therapy on hemophilia A mice].

Authors: Mao, J H, Shen, Y, Wang, Q, Wang, Y, Ruan, Z, Xi, X D

Year: 2020

Venue: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

DOI: https://doi.org/10.3760/cma.j.issn.0253-2727.2020.01.007

Paper Clearance and characterization of residual HSV DNA in recombinant adeno-associated virus produced by an HSV complementation system.

Ye, G-J, Scotti, M M, Liu, J, Wang, L, Knop, D R, Veres, G · 2011 · Gene therapy · DOI

Full title: Clearance and characterization of residual HSV DNA in recombinant adeno-associated virus produced by an HSV complementation system.

Authors: Ye, G-J, Scotti, M M, Liu, J, Wang, L, Knop, D R, Veres, G

Year: 2011

Venue: Gene therapy

DOI: https://doi.org/10.1038/gt.2010.102

Paper Establishment of a novel cell line for the enhanced production of recombinant adeno-associated virus vectors for gene therapy.

Satkunanathan, Stifani, Wheeler, Jun, Thorpe, Robin, Zhao, Yuan · 2014 · Human gene therapy · DOI

Full title: Establishment of a novel cell line for the enhanced production of recombinant adeno-associated virus vectors for gene therapy.

Authors: Satkunanathan, Stifani, Wheeler, Jun, Thorpe, Robin, Zhao, Yuan

Year: 2014

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2014.041

Paper Lentiviral Vector Bioprocessing

Perry, Christopher, Rayat, Andrea · 2021 · Viruses · DOI

Full title: Lentiviral Vector Bioprocessing

Authors: Perry, Christopher, Rayat, Andrea

Year: 2021

Venue: Viruses

DOI: https://doi.org/10.3390/v13020268

Paper Construction and gene expression analysis of a single-stranded DNA minivector based on an inverted terminal repeat of adeno-associated virus.

Ping, Han, Liu, Xiaomei, Zhu, Dongqin, Li, Taiming, Zhang, Chun · 2015 · Molecular biotechnology · DOI

Full title: Construction and gene expression analysis of a single-stranded DNA minivector based on an inverted terminal repeat of adeno-associated virus.

Authors: Ping, Han, Liu, Xiaomei, Zhu, Dongqin, Li, Taiming, Zhang, Chun

Year: 2015

Venue: Molecular biotechnology

DOI: https://doi.org/10.1007/s12033-014-9832-3

Paper Scalable serum-free production of recombinant adeno-associated virus type 2 by transfection of 293 suspension cells.

Durocher, Yves, Pham, Phuong Lan, St-Laurent, Gilles, Jacob, Danielle, Cass, Brian, Chahal, Parminder, Lau, Cara J, Nalbantoglu, Joséphine, Kamen, Amine · 2007 · Journal of virological methods · DOI

Full title: Scalable serum-free production of recombinant adeno-associated virus type 2 by transfection of 293 suspension cells.

Authors: Durocher, Yves, Pham, Phuong Lan, St-Laurent, Gilles, Jacob, Danielle, Cass, Brian, Chahal, Parminder, Lau, Cara J, Nalbantoglu, Joséphine, Kamen, Amine

Year: 2007

Venue: Journal of virological methods

DOI: https://doi.org/10.1016/j.jviromet.2007.03.014

Paper Benchmarking of Scale-X Bioreactor System in Lentiviral and Adenoviral Vector Production

Leinonen, Hanna, Lepola, Saana, Lipponen, Eevi M., Heikura, Tommi, Koponen, Tiina, Parker, Nigel, Ylä‐Herttuala, Seppo, Lesch, Hanna P. · 2020 · Human Gene Therapy · DOI

Full title: Benchmarking of Scale-X Bioreactor System in Lentiviral and Adenoviral Vector Production

Authors: Leinonen, Hanna, Lepola, Saana, Lipponen, Eevi M., Heikura, Tommi, Koponen, Tiina, Parker, Nigel, Ylä‐Herttuala, Seppo, Lesch, Hanna P.

Year: 2020

Venue: Human Gene Therapy

DOI: https://doi.org/10.1089/hum.2019.247

Paper Adeno-Associated Virus Production, Purification, and Titering.

Chen, Yong Hong, Keiser, Megan S, Davidson, Beverly L · 2018 · Current protocols in mouse biology · DOI

Full title: Adeno-Associated Virus Production, Purification, and Titering.

Authors: Chen, Yong Hong, Keiser, Megan S, Davidson, Beverly L

Year: 2018

Venue: Current protocols in mouse biology

DOI: https://doi.org/10.1002/cpmo.56

Paper Suppression of toxic transgene expression by optimized artificial miRNAs increases AAV vector yields in HEK-293 cells.

Blahetek, Gina, Mayer, Christine, Zuber, Johannes, Lenter, Martin, Strobel, Benjamin · 2024 · Molecular therapy. Methods & clinical development · DOI

Full title: Suppression of toxic transgene expression by optimized artificial miRNAs increases AAV vector yields in HEK-293 cells.

Authors: Blahetek, Gina, Mayer, Christine, Zuber, Johannes, Lenter, Martin, Strobel, Benjamin

Year: 2024

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2024.101280

Paper [Regulation of AAV-mediated glial cell-line derived neurotrophic factor expression by using improved Tet-on trans-activator].

Chen, Teng, Li, Xin-Gang, Wu, Cheng-Yuan, Takashi, Okada, Keiya, Ozawa · 2005 · Zhonghua yi xue za zhi

Full title: [Regulation of AAV-mediated glial cell-line derived neurotrophic factor expression by using improved Tet-on trans-activator].

Authors: Chen, Teng, Li, Xin-Gang, Wu, Cheng-Yuan, Takashi, Okada, Keiya, Ozawa

Year: 2005

Venue: Zhonghua yi xue za zhi

Paper Development of Versatile and Flexible Sf9 Packaging Cell Line-Dependent OneBac System for Large-Scale Recombinant Adeno-Associated Virus Production

Wu, Yang, Mei, Ting, Jiang, Liangyu, Han, Zengpeng, Dong, Ruping, Yang, Tian, Xu, Fuqiang · 2019 · Human Gene Therapy Methods · DOI

Full title: Development of Versatile and Flexible Sf9 Packaging Cell Line-Dependent OneBac System for Large-Scale Recombinant Adeno-Associated Virus Production

Authors: Wu, Yang, Mei, Ting, Jiang, Liangyu, Han, Zengpeng, Dong, Ruping, Yang, Tian, Xu, Fuqiang

Year: 2019

Venue: Human Gene Therapy Methods

DOI: https://doi.org/10.1089/hgtb.2019.123

Paper Neuro293: A REST-knockout HEK-293 cell line enables the expression of neuron-restricted genes for the high-throughput testing of human neurobiology and the biochemistry of neuronal proteins.

Moses, Joshua T, Shah, Fahad B, McVay, Nicholas M, Capes, Dylan E, Bosse-Joseph, Christopher C, Salazar, Jocelyn, Slone, Victoria K, Eberth, John E, Satin, Jonathan, Stewart, Andrew N · 2025 · Biology methods & protocols · DOI

Full title: Neuro293: A REST-knockout HEK-293 cell line enables the expression of neuron-restricted genes for the high-throughput testing of human neurobiology and the biochemistry of neuronal proteins.

Authors: Moses, Joshua T, Shah, Fahad B, McVay, Nicholas M, Capes, Dylan E, Bosse-Joseph, Christopher C, Salazar, Jocelyn, Slone, Victoria K, Eberth, John E, Satin, Jonathan, Stewart, Andrew N

Year: 2025

Venue: Biology methods & protocols

DOI: https://doi.org/10.1093/biomethods/bpaf036

Paper Nuclear Fraction Proteome Analyses During rAAV Production of AAV2-Plasmid-Transfected HEK-293 Cells.

Golm, Susanne K, Hoffrogge, Raimund, Müller, Kristian M · 2025 · International journal of molecular sciences · DOI

Full title: Nuclear Fraction Proteome Analyses During rAAV Production of AAV2-Plasmid-Transfected HEK-293 Cells.

Authors: Golm, Susanne K, Hoffrogge, Raimund, Müller, Kristian M

Year: 2025

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms26136315

Paper [Construction and identification of the recombination adeno-associated virus carrying murine FoxP3 gene].

Wang, Sheng-jun, Ma, Jie, Ma, Bin, Mao, Chao-ming, Tong, Jia, Yang, Min, Shao, Qi-xiang, Xu, Hua-xi · 2007 · Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

Full title: [Construction and identification of the recombination adeno-associated virus carrying murine FoxP3 gene].

Authors: Wang, Sheng-jun, Ma, Jie, Ma, Bin, Mao, Chao-ming, Tong, Jia, Yang, Min, Shao, Qi-xiang, Xu, Hua-xi

Year: 2007

Venue: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

Paper Development of a multiplexed RNAi-coupled sensor assay to study neuronal function on the large-scale

Herholt, Alexander · 2017 · DOI

Full title: Development of a multiplexed RNAi-coupled sensor assay to study neuronal function on the large-scale

Authors: Herholt, Alexander

Year: 2017

DOI: https://doi.org/10.53846/goediss-6199

Paper Delivery of dCas9 CRISPR System Into the Hard Transfection Cells by Magnetofection Approach

Ghanbarlou, Mahdi Mohammadi, Abdoli, Shahriyar, Bamehr, Hadi, Qazizadeh, Leila, Omid, Hamed, Iranpour, Hamidreza, Shahsavarani, Hosein, Karimipour, Morteza, Shokrgozar, Mohammad Ali · 2021 · Research Square (Research Square) · DOI

Full title: Delivery of dCas9 CRISPR System Into the Hard Transfection Cells by Magnetofection Approach

Authors: Ghanbarlou, Mahdi Mohammadi, Abdoli, Shahriyar, Bamehr, Hadi, Qazizadeh, Leila, Omid, Hamed, Iranpour, Hamidreza, Shahsavarani, Hosein, Karimipour, Morteza, Shokrgozar, Mohammad Ali

Year: 2021

Venue: Research Square (Research Square)

DOI: https://doi.org/10.21203/rs.3.rs-999842/v1

Paper Adeno-Associated Virus Monoinfection Induces a DNA Damage Response and DNA Repair That Contributes to Viral DNA Replication.

Ning, Kang, Kuz, Cagla Aksu, Cheng, Fang, Feng, Zehua, Yan, Ziying, Qiu, Jianming · 2023 · mBio · DOI

Full title: Adeno-Associated Virus Monoinfection Induces a DNA Damage Response and DNA Repair That Contributes to Viral DNA Replication.

Authors: Ning, Kang, Kuz, Cagla Aksu, Cheng, Fang, Feng, Zehua, Yan, Ziying, Qiu, Jianming

Year: 2023

Venue: mBio

DOI: https://doi.org/10.1128/mbio.03528-22

Paper Formation of newly synthesized adeno-associated virus capsids in the cell nucleus.

Bell, Peter, Vandenberghe, Luk H, Wilson, James M · 2014 · Human gene therapy methods · DOI

Full title: Formation of newly synthesized adeno-associated virus capsids in the cell nucleus.

Authors: Bell, Peter, Vandenberghe, Luk H, Wilson, James M

Year: 2014

Venue: Human gene therapy methods

DOI: https://doi.org/10.1089/hgtb.2014.054

Paper Comprehensive mRNA-sequencing-based characterization of three HEK-293 cell lines during an rAAV production process for gene therapy applications.

Pistek, Martina, Kahlig, Carolin-Isabel, Hackl, Matthias, Unterthurner, Sabine, Kraus, Barbara, Grabherr, Reingard, Grillari, Johannes, Hernandez Bort, Juan A · 2023 · Biotechnology journal · DOI

Full title: Comprehensive mRNA-sequencing-based characterization of three HEK-293 cell lines during an rAAV production process for gene therapy applications.

Authors: Pistek, Martina, Kahlig, Carolin-Isabel, Hackl, Matthias, Unterthurner, Sabine, Kraus, Barbara, Grabherr, Reingard, Grillari, Johannes, Hernandez Bort, Juan A

Year: 2023

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202200513

Paper Synthetic Approaches for Nucleic Acid Delivery: Choosing the Right Carriers

Ni, Rong, Feng, Ruilu, Chau, Ying · 2019 · Life · DOI

Full title: Synthetic Approaches for Nucleic Acid Delivery: Choosing the Right Carriers

Authors: Ni, Rong, Feng, Ruilu, Chau, Ying

Year: 2019

Venue: Life

DOI: https://doi.org/10.3390/life9030059

Paper AAV Gene Transfer to the Heart.

Wang, Suya, Guo, Yuxuan, Pu, William T · 2021 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: AAV Gene Transfer to the Heart.

Authors: Wang, Suya, Guo, Yuxuan, Pu, William T

Year: 2021

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-0716-0668-1_20

Paper Modifiers of Adeno-Associated Virus-Mediated Gene Expression in Implication for Serotype-Universal Neutralizing Antibody Assay

Krotova, Karina, Aslanidi, George · 2020 · Human Gene Therapy · DOI

Full title: Modifiers of Adeno-Associated Virus-Mediated Gene Expression in Implication for Serotype-Universal Neutralizing Antibody Assay

Authors: Krotova, Karina, Aslanidi, George

Year: 2020

Venue: Human Gene Therapy

DOI: https://doi.org/10.1089/hum.2020.074

Paper Engineered genetic tools for directed gene regulation

Ferreira, Rafael Rinaldi · 2021 · DOI

Full title: Engineered genetic tools for directed gene regulation

Authors: Ferreira, Rafael Rinaldi

Year: 2021

DOI: https://doi.org/10.53846/goediss-8703

Paper Scalable Lentiviral Vector Production Using Stable HEK293SF Producer Cell Lines

Manceur, Aziza, Kim, Howard S., Misic, Vanja, Andreev, Nadejda, Dorion-Thibaudeau, July, Lanthier, Stéphane, Bernier, Alice, Tremblay, Sonia, Gélinas, Anne-Marie, Broussau, Sophie, Gilbert, Rénald, Ansorge, Sven · 2017 · Human Gene Therapy Methods · DOI

Full title: Scalable Lentiviral Vector Production Using Stable HEK293SF Producer Cell Lines

Authors: Manceur, Aziza, Kim, Howard S., Misic, Vanja, Andreev, Nadejda, Dorion-Thibaudeau, July, Lanthier, Stéphane, Bernier, Alice, Tremblay, Sonia, Gélinas, Anne-Marie, Broussau, Sophie, Gilbert, Rénald, Ansorge, Sven

Year: 2017

Venue: Human Gene Therapy Methods

DOI: https://doi.org/10.1089/hgtb.2017.086

Paper Enhanced Adeno‐Associated Virus Production in HEK293 Cells via Dual Inducible Control of Cap and Rep Proteins

He Ren, Jianqi Nie, Zichuan Song, Yankun Yang, Zhonghu Bai · 2025 · Biotechnology and Bioengineering · DOI

Full title: Enhanced Adeno‐Associated Virus Production in HEK293 Cells via Dual Inducible Control of Cap and Rep Proteins

Authors: He Ren, Jianqi Nie, Zichuan Song, Yankun Yang, Zhonghu Bai

Year: 2025

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.70013

Paper Construction and optimization of novel recombinant Adeno-Associated Virus rAAV2/5 for targeting microglia to regulate immune responses during neuroinflammation

Belhoul‐Fakir, Hanane · 2014 · DOI

Full title: Construction and optimization of novel recombinant Adeno-Associated Virus rAAV2/5 for targeting microglia to regulate immune responses during neuroinflammation

Authors: Belhoul‐Fakir, Hanane

Year: 2014

DOI: https://doi.org/10.26686/wgtn.17008231

Paper Inducible HEK293 AAV packaging cell lines expressing Rep proteins.

Jalšić, Lovro, Lytvyn, Viktoria, Elahi, Seyyed Mehdy, Hrapovic, Sabahudin, Nassoury, Nasha, Chahal, Parminder Singh, Gaillet, Bruno, Gilbert, Rénald · 2023 · Molecular therapy. Methods & clinical development · DOI

Full title: Inducible HEK293 AAV packaging cell lines expressing Rep proteins.

Authors: Jalšić, Lovro, Lytvyn, Viktoria, Elahi, Seyyed Mehdy, Hrapovic, Sabahudin, Nassoury, Nasha, Chahal, Parminder Singh, Gaillet, Bruno, Gilbert, Rénald

Year: 2023

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2023.07.002

Paper Engineering of the CMV promoter for controlled expression of recombinant genes in HEK293 cells

Johari, Yusuf B., Scarrott, Joseph M., Pohle, Thilo H., Liu, Ping, Mayer, Ayda, Brown, Adam, James, David C. · 2022 · Biotechnology Journal · DOI

Full title: Engineering of the CMV promoter for controlled expression of recombinant genes in HEK293 cells

Authors: Johari, Yusuf B., Scarrott, Joseph M., Pohle, Thilo H., Liu, Ping, Mayer, Ayda, Brown, Adam, James, David C.

Year: 2022

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202200062

Paper High-Level rAAV Vector Production by rAdV-Mediated Amplification of Small Amounts of Input Vector

Weger, Stefan · 2022 · Viruses · DOI

Full title: High-Level rAAV Vector Production by rAdV-Mediated Amplification of Small Amounts of Input Vector

Authors: Weger, Stefan

Year: 2022

Venue: Viruses

DOI: https://doi.org/10.3390/v15010064

Paper Recombinant Adeno-Associated Virus-Mediated Gene Therapy for Treatment of Familial Hypercholesterolemia in Rabbits

Atlas, Daniel, Buckshaw, Elizabeth, Hanna, David B., Lannon, Jennifer, Mahmud, Alia, Mirvis, Mary, Pham, Anna C., Ramnarain, Nadira, Randazzo, Paul A., Safferman, Michelle, Zuckerberg, Jeremy · 2013 · University Libraries (University of Maryland)

Full title: Recombinant Adeno-Associated Virus-Mediated Gene Therapy for Treatment of Familial Hypercholesterolemia in Rabbits

Authors: Atlas, Daniel, Buckshaw, Elizabeth, Hanna, David B., Lannon, Jennifer, Mahmud, Alia, Mirvis, Mary, Pham, Anna C., Ramnarain, Nadira, Randazzo, Paul A., Safferman, Michelle, Zuckerberg, Jeremy

Year: 2013

Venue: University Libraries (University of Maryland)

Paper AAV Vectors Pseudotyped with Capsids from Porcine and Bovine Species Mediate In Vitro and In Vivo Gene Delivery

Yu, Darrick L., Lieshout, Laura P. van, Stevens, Brenna A. Y., Near, Kelsie J., Stodola, Jenny K., Stinson, Kevin J., Slavić, Ðurđa, Wootton, Sarah K. · 2023 · Viruses · DOI

Full title: AAV Vectors Pseudotyped with Capsids from Porcine and Bovine Species Mediate In Vitro and In Vivo Gene Delivery

Authors: Yu, Darrick L., Lieshout, Laura P. van, Stevens, Brenna A. Y., Near, Kelsie J., Stodola, Jenny K., Stinson, Kevin J., Slavić, Ðurđa, Wootton, Sarah K.

Year: 2023

Venue: Viruses

DOI: https://doi.org/10.3390/v16010057

Paper Production of Recombinant Adeno-Associated Viruses (rAAVs) by Transient Transfection.

Su, Qin, Sena-Esteves, Miguel, Gao, Guangping · 2020 · Cold Spring Harbor protocols · DOI

Full title: Production of Recombinant Adeno-Associated Viruses (rAAVs) by Transient Transfection.

Authors: Su, Qin, Sena-Esteves, Miguel, Gao, Guangping

Year: 2020

Venue: Cold Spring Harbor protocols

DOI: https://doi.org/10.1101/pdb.prot095596

Paper Chitosan for Gene Delivery and Orthopedic Tissue Engineering Applications

Raftery, Rosanne M., O’Brien, Fergal J., Cryan, Sally‐Ann · 2013 · Molecules · DOI

Full title: Chitosan for Gene Delivery and Orthopedic Tissue Engineering Applications

Authors: Raftery, Rosanne M., O’Brien, Fergal J., Cryan, Sally‐Ann

Year: 2013

Venue: Molecules

DOI: https://doi.org/10.3390/molecules18055611

Paper Tuning capsid formation dynamics in recombinant adeno‐associated virus producing synthetic cell lines to enhance full particle productivity

Lu, Min, Lin, Yu‐Chieh, Kuo, Han‐Jung, Wen, Cai, Ye, Qian, Zhao, Liang, Hu, Wei‐Shou · 2024 · Biotechnology Journal · DOI

Full title: Tuning capsid formation dynamics in recombinant adeno‐associated virus producing synthetic cell lines to enhance full particle productivity

Authors: Lu, Min, Lin, Yu‐Chieh, Kuo, Han‐Jung, Wen, Cai, Ye, Qian, Zhao, Liang, Hu, Wei‐Shou

Year: 2024

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202400051

Paper [Construction of an adenoassociated, viral derived, expression vector to correct the genetic defect in Morquio A disease].

Gutiérrez, Mónica A, García-Vallejo, Felipe, Tomatsu, Shunji, Cerón, Flavio, Alméciga-Díaz, Carlos J, Domínguez, Martha C, Barrera, Luis A · 2008 · Biomedica : revista del Instituto Nacional de Salud

Full title: [Construction of an adenoassociated, viral derived, expression vector to correct the genetic defect in Morquio A disease].

Authors: Gutiérrez, Mónica A, García-Vallejo, Felipe, Tomatsu, Shunji, Cerón, Flavio, Alméciga-Díaz, Carlos J, Domínguez, Martha C, Barrera, Luis A

Year: 2008

Venue: Biomedica : revista del Instituto Nacional de Salud

Paper Molecular design of controllable recombinant adeno-associated virus (AAV) expression systems for enhanced vector production.

Johari, Yusuf B, Pohle, Thilo H, Whitehead, Jared, Scarrott, Joseph M, Liu, Ping, Mayer, Ayda, James, David C · 2024 · Biotechnology journal · DOI

Full title: Molecular design of controllable recombinant adeno-associated virus (AAV) expression systems for enhanced vector production.

Authors: Johari, Yusuf B, Pohle, Thilo H, Whitehead, Jared, Scarrott, Joseph M, Liu, Ping, Mayer, Ayda, James, David C

Year: 2024

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202300685

Paper Regulation of Blood Pressure by Targeting CaV1.2-Galectin-1 Protein Interaction.

Hu, Zhenyu, Li, Guang, Wang, Jiong-Wei, Chong, Suet Yen, Yu, Dejie, Wang, Xiaoyuan, Soon, Jia Lin, Liang, Mui Cheng, Wong, Yuk Peng, Huang, Na, Colecraft, Henry M, Liao, Ping, Soong, Tuck Wah · 2018 · Circulation · DOI

Full title: Regulation of Blood Pressure by Targeting CaV1.2-Galectin-1 Protein Interaction.

Authors: Hu, Zhenyu, Li, Guang, Wang, Jiong-Wei, Chong, Suet Yen, Yu, Dejie, Wang, Xiaoyuan, Soon, Jia Lin, Liang, Mui Cheng, Wong, Yuk Peng, Huang, Na, Colecraft, Henry M, Liao, Ping, Soong, Tuck Wah

Year: 2018

Venue: Circulation

DOI: https://doi.org/10.1161/CIRCULATIONAHA.117.031231

Paper Magnetic resonance imaging of infarct-induced canonical wingless/integrated (Wnt)/β-catenin/T-cell factor pathway activation, in vivo.

Matteucci, Marco, Casieri, Valentina, Gabisonia, Khatia, Aquaro, Giovanni Donato, Agostini, Silvia, Pollio, Giuseppe, Diamanti, Daniela, Rossi, Marco, Travagli, Massimiliano, Porcari, Valentina, Recchia, Fabio A, Lionetti, Vincenzo · 2016 · Cardiovascular research · DOI

Full title: Magnetic resonance imaging of infarct-induced canonical wingless/integrated (Wnt)/β-catenin/T-cell factor pathway activation, in vivo.

Authors: Matteucci, Marco, Casieri, Valentina, Gabisonia, Khatia, Aquaro, Giovanni Donato, Agostini, Silvia, Pollio, Giuseppe, Diamanti, Daniela, Rossi, Marco, Travagli, Massimiliano, Porcari, Valentina, Recchia, Fabio A, Lionetti, Vincenzo

Year: 2016

Venue: Cardiovascular research

DOI: https://doi.org/10.1093/cvr/cvw214

Paper British Society for Gene and Cell Therapy Annual Conference Wednesday 19th June – Friday 21st June 2019 University of Sheffield, Sheffield, UK www.bsgct.org

RV, Bell,, TAJ, McKinnon,, EWFW, Alton,, U, Griesenbach, · 2019 · Human Gene Therapy · DOI

Full title: British Society for Gene and Cell Therapy Annual Conference Wednesday 19th June – Friday 21st June 2019 University of Sheffield, Sheffield, UK www.bsgct.org

Authors: RV, Bell,, TAJ, McKinnon,, EWFW, Alton,, U, Griesenbach,

Year: 2019

Venue: Human Gene Therapy

DOI: https://doi.org/10.1089/hum.2019.29087.abstracts

Thesis High-density transfection with HEK-293 cells allows doubling of transient titers and removes need for a priori DNA complex formation with PEI

Backliwal, Gaurav; Hildinger, Markus; Hasija, Vivek et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: High-density transfection with HEK-293 cells allows doubling of transient titers and removes need for a priori DNA complex formation with PEI

Authors: Backliwal, Gaurav; Hildinger, Markus; Hasija, Vivek; Wurm, Florian M.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/58379

Thesis Serum-free large-scale transient transfection of CHO cells

Derouazi, M.; Girard, P.; Van Tilborgh, F. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Serum-free large-scale transient transfection of CHO cells

Authors: Derouazi, M.; Girard, P.; Van Tilborgh, F.; Iglesias, K.; Muller, N.; Bertschinger, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7662

Thesis Biocompatible Polymer-Peptide Hybrid-Based DNA Nanoparticles for Gene Delivery

Witzigmann, Dominik; Wu, Dalin; Schenk, Susanne H. et al. · 2025 · University of Basel - edoc Repository · DOI

Full title: Biocompatible Polymer-Peptide Hybrid-Based DNA Nanoparticles for Gene Delivery

Authors: Witzigmann, Dominik; Wu, Dalin; Schenk, Susanne H.; Balasubramanian, Vimalkumar; Meier, Wolfgang P.; Huwyler, Jörg

Year: 2025

Venue: University of Basel - edoc Repository

DOI: http://hdl.handle.net/20.500.14716/42305

Thesis Development of pooled perturbation approaches for neurodegenerative phenotypes and therapeutic strategies

O'Driscoll, Emily, Elizabeth · 2025 · University of Pennsylvania · DOI

Full title: Development of pooled perturbation approaches for neurodegenerative phenotypes and therapeutic strategies

Authors: O'Driscoll, Emily, Elizabeth

Year: 2025

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/61270

Thesis Orbital shaker technology for the cultivation of mammalian cells in suspension

Muller, N.; Girard, P.; Hacker, D. L. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Orbital shaker technology for the cultivation of mammalian cells in suspension

Authors: Muller, N.; Girard, P.; Hacker, D. L.; Jordan, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7671

Thesis Desenvolupament i anàlisi d'un bioprocés per a l'obtenció de vectors adenovirals per a teràpia gènica

Gálvez Sánchez, Jordi · 2011 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Desenvolupament i anàlisi d'un bioprocés per a l'obtenció de vectors adenovirals per a teràpia gènica

Authors: Gálvez Sánchez, Jordi

Year: 2011

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://www.tdx.cat/TDX-0214111-150511

Thesis Non-viral Transfection and Direct Reprogramming of Fibroblasts to Neurons and Glia: Importance of Physical and Chemical Microenvironments

Adler, Andrew Frederick · 2014 · Duke University · DOI

Full title: Non-viral Transfection and Direct Reprogramming of Fibroblasts to Neurons and Glia: Importance of Physical and Chemical Microenvironments

Authors: Adler, Andrew Frederick

Year: 2014

Venue: Duke University

DOI: https://hdl.handle.net/10161/9048

Thesis Selective inhibition of histone deacetylation in melanoma increases targeted gene delivery by a bacteriophage viral vector

Hajitou, A; Campbell, Samuel; Suwan, Keittisak et al. · 2018 · Imperial College London · DOI

Full title: Selective inhibition of histone deacetylation in melanoma increases targeted gene delivery by a bacteriophage viral vector

Authors: Hajitou, A; Campbell, Samuel; Suwan, Keittisak; Waramit, Sajee; Aboagye, eric

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/59229

Thesis Application of pulsed-magnetic field enhances non-viral gene delivery in primary cells from different origins

Kamau Chapman, Sarah W.; Hassa, Paul O.; Koch-Schneidemann, Sabine et al. · 2008 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Application of pulsed-magnetic field enhances non-viral gene delivery in primary cells from different origins

Authors: Kamau Chapman, Sarah W.; Hassa, Paul O.; Koch-Schneidemann, Sabine; von Rechenberg, Brigitte; Hofmann-Amtenbrink, Margarethe; Steitz, Benedikt; Petri-Fink, Alke; Hofmann, Heinrich; Hottiger, Michael O.

Year: 2008

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/17215

Thesis Lactate as an indicator of terminating time in insect cell culture baculovirus expression vector systems

Clausen, A.; Svendsen, I.; Emborg, Claus · 1996 · Technical University of Denmark (DTU) · DOI

Full title: Lactate as an indicator of terminating time in insect cell culture baculovirus expression vector systems

Authors: Clausen, A.; Svendsen, I.; Emborg, Claus

Year: 1996

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/14208bd4-3bb6-4bbd-8240-bad3fc16ec3a

Thesis Impact of chemically defined culture media formulations on extracellular vesicle production by amniotic epithelial cells

Zhu, D; Fang, H; Kusuma, GD et al. · 2023 · University of Melbourne · DOI

Full title: Impact of chemically defined culture media formulations on extracellular vesicle production by amniotic epithelial cells

Authors: Zhu, D; Fang, H; Kusuma, GD; Schwab, R; Barabadi, M; Chan, ST; McDonald, H; Leong, CM; Wallace, EM; Greening, DW; Lim, R

Year: 2023

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/338110

Thesis Polyethyleneimine-based transient gene expression processes for suspension-adapted HEK-293E and CHO-DG44 cells

Hacker, David L.; Kiseljak, Divor; Rajendra, Yashas et al. · 2013 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Polyethyleneimine-based transient gene expression processes for suspension-adapted HEK-293E and CHO-DG44 cells

Authors: Hacker, David L.; Kiseljak, Divor; Rajendra, Yashas; Thurnheer, Sarah; Baldi, Lucia; Wurm, Florian M.

Year: 2013

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/97430

Thesis Closing the gap: Nonviral TFAMoplex transfection boosted by bZIP domains compared to AAV-mediated transduction

Honrath, Steffen; id_orcid0009-0003-7513-8872; Heussi, Miguel et al. · 2025 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Closing the gap: Nonviral TFAMoplex transfection boosted by bZIP domains compared to AAV-mediated transduction

Authors: Honrath, Steffen; id_orcid0009-0003-7513-8872; Heussi, Miguel; Beckert, Lukas; Scherer, David; Lim, Roderick Y.H.; Burger, Michael; Leroux, Jean-Christophe; id_orcid0009-0003-7513-8872

Year: 2025

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/731449

Thesis Extracellular vesicles: nature's nanoparticles for improving gene transfer with adeno-associated virus vectors

György, B; Maguire, CA · 2025 · University of Basel - edoc Repository · DOI

Full title: Extracellular vesicles: nature's nanoparticles for improving gene transfer with adeno-associated virus vectors

Authors: György, B; Maguire, CA

Year: 2025

Venue: University of Basel - edoc Repository

DOI: https://hdl.handle.net/20.500.14716/58047

Thesis Minicircle DNA-mediated endothelial nitric oxide synthase gene transfer enhances angiogenic responses of bone marrow-derived mesenchymal stem cells

Bandara, Nadeeka; Gurusinghe, Saliya; id_orcid 0000-0001-5779-3468 et al. · 2016 · Charles Sturt University - Research Output · DOI

Full title: Minicircle DNA-mediated endothelial nitric oxide synthase gene transfer enhances angiogenic responses of bone marrow-derived mesenchymal stem cells

Authors: Bandara, Nadeeka; Gurusinghe, Saliya; id_orcid 0000-0001-5779-3468; Chen, Haiying; Chen, Shuangfeng; Wang, Le-xin; Lim, Shiang Y.; Strappe, Padraig

Year: 2016

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/2145c668-9a85-476f-ad9f-0ad11c4bcb60

Thesis Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool

Puarattana-aroonkorn, Sitthiphol; Tharakaraman, Kannan; Suriyawipada, Disapan et al. · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool

Authors: Puarattana-aroonkorn, Sitthiphol; Tharakaraman, Kannan; Suriyawipada, Disapan; Ruchirawat, Mathuros; Fuangthong, Mayuree; Sasisekharan, Ram; Artpradit, Charlermchai

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/155543

Thesis Minicircle mediated gene delivery to canine and equine mesenchymal stem cells

Tidd, Naomie; Michelsen, Jacob; Hilbert, Bryan et al. · 2017 · Charles Sturt University - Research Output · DOI

Full title: Minicircle mediated gene delivery to canine and equine mesenchymal stem cells

Authors: Tidd, Naomie; Michelsen, Jacob; Hilbert, Bryan; Quinn, Jane C.; id_orcid 0000-0002-9310-0291

Year: 2017

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/90e70eeb-5b16-4ca1-b136-aa86be060343

Thesis Recombinant therapeutic protein production in cultivated mammalian cells: current status and future prospects

Matasci, Mattia; Hacker, David L.; Baldi, Lucia et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Recombinant therapeutic protein production in cultivated mammalian cells: current status and future prospects

Authors: Matasci, Mattia; Hacker, David L.; Baldi, Lucia; Wurm, Florian M.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/48115

Thesis Improved Methods for Anterograde Axonal Tracing by Viral Vectors

Dogra, Sachi · 2025 · University of California, San Diego (UCSD) · DOI

Full title: Improved Methods for Anterograde Axonal Tracing by Viral Vectors

Authors: Dogra, Sachi

Year: 2025

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/4pj7s913

Thesis A systematic study of transfection efficiency and cytotoxicity in HeLa cells using iron oxide nanoparticles prepared with organic and inorganic bases

Calmon, Marilia de Freitas [UNESP]; de Souza, Aryane Tofanello [UNESP]; Candido, Natalia Maria [UNESP] et al. · 2014 · Universidade Estadual Paulista (UNESP) · DOI

Full title: A systematic study of transfection efficiency and cytotoxicity in HeLa cells using iron oxide nanoparticles prepared with organic and inorganic bases

Authors: Calmon, Marilia de Freitas [UNESP]; de Souza, Aryane Tofanello [UNESP]; Candido, Natalia Maria [UNESP]; Bartolomeu Raposo, Maria Irene; Taboga, Sebastiao [UNESP]; Rahal, Paula [UNESP]; Nery, Jose G. [UNESP]

Year: 2014

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1016/j.colsurfb.2012.05.026

Thesis Optogenetic gene therapy for vision restoration

Hickey, D · 2015 · University of Oxford - ORA · DOI

Full title: Optogenetic gene therapy for vision restoration

Authors: Hickey, D

Year: 2015

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:820a45d5-60db-4c01-808a-8a3720c48f2c

Thesis Gene replacement ameliorates deficits in mouse and human models of cyclin-dependent kinase-like 5 disorder

Yunan Gao, Yunan; Irvine, Elaine; Eleftheriadou, Ioanna et al. · 2020 · Imperial College London · DOI

Full title: Gene replacement ameliorates deficits in mouse and human models of cyclin-dependent kinase-like 5 disorder

Authors: Yunan Gao, Yunan; Irvine, Elaine; Eleftheriadou, Ioanna; Naranjo, Carlos Jimenez; Hearn-Yeats, Francesca; Bosch, Leontien; Glegola, Justina; Murdoch, Leah; Czerniak, Aleksandra; Meloni, Ilaria; Renieri, Alessandra; Kinali, Maria; Mazarakis, Nicholas D

Year: 2020

Venue: Imperial College London

DOI: https://academic.oup.com/brain/article/143/3/811/5775569

Thesis High Throughput Screening for the Enhancement of Adeno-Associated Virus Type 2 Transduction

Wallen, Alexis J · 2023 · University of Pennsylvania · DOI

Full title: High Throughput Screening for the Enhancement of Adeno-Associated Virus Type 2 Transduction

Authors: Wallen, Alexis J

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/30848

Thesis Efficient transduction of equine adipose-derived mesenchymal stem cells by VSV-G pseudotyped lentiviral vectors

Petersen, Gayle; Hilbert, Bryan; Trope, Gareth et al. · 2014 · Charles Sturt University - Research Output · DOI

Full title: Efficient transduction of equine adipose-derived mesenchymal stem cells by VSV-G pseudotyped lentiviral vectors

Authors: Petersen, Gayle; Hilbert, Bryan; Trope, Gareth; Kalle, Wouter; Strappe, Padraig

Year: 2014

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/9869d18a-73ab-4ebc-94dc-1a551979ee18

Thesis Epicardial cell transfection with cationic polymeric nanocomplexes

Brito, L; Mylonaki, I; Moroz, E et al. · 2020 · Imperial College London · DOI

Full title: Epicardial cell transfection with cationic polymeric nanocomplexes

Authors: Brito, L; Mylonaki, I; Moroz, E; Grigsby, C; Smart, N; Rosenthal, N; Harding, SE; Stevens, MM

Year: 2020

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000462496800033&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis High Efficiency Low Cost Fibroblast Nucleofection for GMP Compatible Cell-based Gene Therapy.

Zhang, Ziyang; Slobodianski, Alex; Arnold, Astrid et al. · 2017 · Technical University of Munich (TUM) · DOI

Full title: High Efficiency Low Cost Fibroblast Nucleofection for GMP Compatible Cell-based Gene Therapy.

Authors: Zhang, Ziyang;Slobodianski, Alex;Arnold, Astrid;Nehlsen, Jessica;Hopfner, Ursula;Schilling, Arndt F;Perisic, Tatjana;Machens, Hans-Günther

Year: 2017

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1435929

Thesis Targeted Gene Delivery via N-Acetylglucosamine Receptor Mediated Endocytosis

Singh, Bijay; Maharjan, Sushila; Kim, You-Kyoung et al. · 2021 · Seoul National University · DOI

Full title: Targeted Gene Delivery via N-Acetylglucosamine Receptor Mediated Endocytosis

Authors: Singh, Bijay; Maharjan, Sushila; Kim, You-Kyoung; Jiang, Tao; Islam, Mohammad Ariful; Kang, Sang-Kee; Cho, Myung-Haing; Choi, Yun-Jaie; Cho, Chong-Su

Year: 2021

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/172437

Thesis Systematic insights into cell density-dependent transcriptional responses upon medium replacements

Pérez-Rubio, Pol; Romero, Elianet Lorenzo; Cervera, Laura et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Systematic insights into cell density-dependent transcriptional responses upon medium replacements

Authors: Pérez-Rubio, Pol; Romero, Elianet Lorenzo; Cervera, Laura; Gòdia, Francesc; Nielsen, Lars Keld; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2c104764-6292-43ba-8eaf-c03af53bbcf2

Thesis Magnetofection Enhances Adenoviral Vector-based Gene Delivery in Skeletal Muscle Cells.

Pereyra, Andrea Soledad; Mykhaylyk, Olga; Lockhart, Eugenia Falomir et al. · 2016 · Technical University of Munich (TUM) · DOI

Full title: Magnetofection Enhances Adenoviral Vector-based Gene Delivery in Skeletal Muscle Cells.

Authors: Pereyra, Andrea Soledad;Mykhaylyk, Olga;Lockhart, Eugenia Falomir;Taylor, Jackson Richard;Delbono, Osvaldo;Goya, Rodolfo Gustavo;Plank, Christian;Hereñu, Claudia Beatriz

Year: 2016

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1362909

Thesis Internalization of PEI-based complexes in transient transfection of HEK293 cells is triggered by coalescence of membrane heparan sulfate proteoglycans like Glypican-4

Pérez-Rubio, Pol; Vendrell-Flotats, Meritxell; Romero, Elianet Lorenzo et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Internalization of PEI-based complexes in transient transfection of HEK293 cells is triggered by coalescence of membrane heparan sulfate proteoglycans like Glypican-4

Authors: Pérez-Rubio, Pol; Vendrell-Flotats, Meritxell; Romero, Elianet Lorenzo; Enemark-Rasmussen, Kasper; id_orcid 0000-0001-7455-7512; Cervera, Laura; Gòdia, Francesc; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/6367220f-a1a7-48e0-9fec-42d38dbb1694

Thesis Poloxamer synperonic F108 improves cellular transduction with lentiviral vectors.

Höfig, I; Atkinson, MJ; Mall, S et al. · 2012 · Technical University of Munich (TUM) · DOI

Full title: Poloxamer synperonic F108 improves cellular transduction with lentiviral vectors.

Authors: Höfig, I;Atkinson, MJ;Mall, S;Krackhardt, AM;Thirion, C;Anastasov, N

Year: 2012

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1181656

Thesis Chemical modification of chitosan as a gene carrier in vitro and in vivo

Kim, Tae-Hee; Jiang, Hu-Lin; Jere, Dhananjay et al. · 2009 · Seoul National University · DOI

Full title: Chemical modification of chitosan as a gene carrier in vitro and in vivo

Authors: Kim, Tae-Hee; Jiang, Hu-Lin; Jere, Dhananjay; Park, In-Kyu; Cho, Myung-Haing; Nah, Jae-Woon; Choi, Yun-Jale; Akaike, Toshihiro; Cho, Chong-Su

Year: 2009

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/8337

Thesis BRIDGING EXPERIMENTAL AND IN-SILICO METHODS FOR ADVANCED MAMMALIAN BIOMANUFACTURING OPTIMIZATION

Ndahiro, Nelson · 2025 · Johns Hopkins University · DOI

Full title: BRIDGING EXPERIMENTAL AND IN-SILICO METHODS FOR ADVANCED MAMMALIAN BIOMANUFACTURING OPTIMIZATION

Authors: Ndahiro, Nelson

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70287

Thesis Capsule-like safe genetic vectors — cell-penetrating core – shell particles selectively release functional small RNA and entrap its encoding DNA

Yu, Han; Pan, Matthew Houwen; Evalin et al. · 2020 · Nanyang Technological University (NTU) · DOI

Full title: Capsule-like safe genetic vectors — cell-penetrating core – shell particles selectively release functional small RNA and entrap its encoding DNA

Authors: Yu, Han; Pan, Matthew Houwen; Evalin; Trau, Dieter; Patzel, Volker

Year: 2020

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/141342

Thesis Enhanced nanomagnetic gene transfection of human prenatal cardiac progenitor cells and adult cardiomyocytes

Subramanian, Mahendran; Lim, Jenson; Dobson, Jon · 2020 · Imperial College London · DOI

Full title: Enhanced nanomagnetic gene transfection of human prenatal cardiac progenitor cells and adult cardiomyocytes

Authors: Subramanian, Mahendran; Lim, Jenson; Dobson, Jon

Year: 2020

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000322633700046&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Internalization of PEI-based complexes in transient transfection of HEK293 cells is triggered by coalescence of membrane heparan sulfate proteoglycans like Glypican-4

Pérez-Rubio, Pol; Vendrell-Flotats, Meritxell; Romero, Elianet Lorenzo et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Internalization of PEI-based complexes in transient transfection of HEK293 cells is triggered by coalescence of membrane heparan sulfate proteoglycans like Glypican-4

Authors: Pérez-Rubio, Pol; Vendrell-Flotats, Meritxell; Romero, Elianet Lorenzo; Enemark-Rasmussen, Kasper; id_orcid 0000-0001-7455-7512; Cervera, Laura; Gòdia, Francesc; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/6367220f-a1a7-48e0-9fec-42d38dbb1694

Thesis Transcriptional and post-transcriptional limitations of high-yielding, PEI-mediated transient transfection with CHO and HEK-293E cells

Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia et al. · 2015 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transcriptional and post-transcriptional limitations of high-yielding, PEI-mediated transient transfection with CHO and HEK-293E cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia; Wurm, Florian M.; Hacker, David L.

Year: 2015

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/113973

Thesis Optimization of Novel Lipid Nanoparticle Formulations for mRNA Delivery

Bohmer, Margaret · 2022 · The Ohio State University · DOI

Full title: Optimization of Novel Lipid Nanoparticle Formulations for mRNA Delivery

Authors: Bohmer, Margaret

Year: 2022

Venue: The Ohio State University

DOI: http://hdl.handle.net/1811/101272

Thesis Epizone: Interlaboratory Ring Trial to Compare Dna Transfection Efficiencies

Dory, Daniel; Albina, Emmanuel; Kwiatek, Olivier et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: Epizone: Interlaboratory Ring Trial to Compare Dna Transfection Efficiencies

Authors: Dory, Daniel; Albina, Emmanuel; Kwiatek, Olivier; Keil, Guenther; Finke, Stefan; Fuchs, Walter; Kluup, Barbara; König, Patricia; Dixon, Linda; Goatley, Lynnette; Takamatsu, Haru; Borrego, Belen; Brun, Alejandro; Ortego, Javier; Friis, Martin Barfred; Lorenzen, Niels; id_orcid 0000-0002-6946-3252; Rasmussen, Thomas Bruun; Schyth, Brian Dall; Crooke, Helen; Sosan, Olbukola

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/13cec1b4-21dc-400d-8868-fdb9a9a75c2e

Thesis Use of uniform designs in combination with neural networks for viral infection process development

Buenno, Laís Hara; Rocha, José Celso; Leme, Jaci et al. · 2015 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Use of uniform designs in combination with neural networks for viral infection process development

Authors: Buenno, Laís Hara; Rocha, José Celso; Leme, Jaci; Caricati, Celso Pereira; Tonso, Aldo; Nuñez, Eutimio Gustavo Fernández [UNESP]

Year: 2015

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://onlinelibrary.wiley.com/doi/10.1002/btpr.2051/abstract

Thesis Unravelling the essential elements for recombinant adeno-associated virus (rAAV) production in animal cell-based platforms

Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Tzimou, Konstantina et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Unravelling the essential elements for recombinant adeno-associated virus (rAAV) production in animal cell-based platforms

Authors: Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Tzimou, Konstantina; Nielsen, Lars K.; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/00e28410-d986-4a71-bcb4-7e64bcd223a2

Thesis Comparison of Three Transposons for the Generation of Highly Productive Recombinant CHO Cell Pools and Cell Lines

Balasubramanian, Sowmya; Rajendra, Yashas; Baldi, Lucia et al. · 2016 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Comparison of Three Transposons for the Generation of Highly Productive Recombinant CHO Cell Pools and Cell Lines

Authors: Balasubramanian, Sowmya; Rajendra, Yashas; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2016

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/127664

Thesis Development of a self-silencing adenovirus for the efficient manufacture of adeno-associated virus vectors

Su, W · 2021 · University of Oxford - ORA · DOI

Full title: Development of a self-silencing adenovirus for the efficient manufacture of adeno-associated virus vectors

Authors: Su, W

Year: 2021

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:bf702b24-b539-4255-81fa-0b94da36d363

Thesis Engineering pseudovirions for large-scale targeted gene transfer and recombinant adeno-associated virus production

Asavarut, Paladd · 2021 · Imperial College London · DOI

Full title: Engineering pseudovirions for large-scale targeted gene transfer and recombinant adeno-associated virus production

Authors: Asavarut, Paladd

Year: 2021

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/86379

Thesis HIV-1 as a Target for the Cas9 DNA Editing Enzyme and the Development of Novel sgRNA Expression Technology

Mefferd, Adam · 2018 · Duke University · DOI

Full title: HIV-1 as a Target for the Cas9 DNA Editing Enzyme and the Development of Novel sgRNA Expression Technology

Authors: Mefferd, Adam

Year: 2018

Venue: Duke University

DOI: https://hdl.handle.net/10161/16949

Thesis The magnetofection method: using magnetic force to enhance gene delivery.

Plank, C; Schillinger, U; Scherer, F et al. · 2003 · Technical University of Munich (TUM) · DOI

Full title: The magnetofection method: using magnetic force to enhance gene delivery.

Authors: Plank, C;Schillinger, U;Scherer, F;Bergemann, C;Remy, JS;Krötz, F;Anton, M;Lausier, J;Rosenecker, J

Year: 2003

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1330218

Thesis Lentiviral delivery of CRISPR Cas9 prime editing system for cystic fibrosis

Satyapertiwi, D · 2024 · University of Oxford - ORA · DOI

Full title: Lentiviral delivery of CRISPR Cas9 prime editing system for cystic fibrosis

Authors: Satyapertiwi, D

Year: 2024

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:65e46bd6-d43b-440f-b906-1ec4323337ae

Thesis Large-Scale mRNA Transfection of Dendritic Cells by Electroporation in Continuous Flow Systems

Selmeczi, Dávid; Hansen, Thomas Steen; Met, Özcan et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Large-Scale mRNA Transfection of Dendritic Cells by Electroporation in Continuous Flow Systems

Authors: Selmeczi, Dávid; Hansen, Thomas Steen; Met, Özcan; Svane, Inge Marie; Larsen, Niels Bent; id_orcid 0000-0001-6506-3991

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/48539b2c-01af-4cff-baa9-38f7cbdfdf40

Thesis Magselectofection: an integrated method of nanomagnetic separation and genetic modification of target cells.

Sánchez-Antequera, Y; Mykhaylyk, O; van Til, NP et al. · 2011 · Technical University of Munich (TUM) · DOI

Full title: Magselectofection: an integrated method of nanomagnetic separation and genetic modification of target cells.

Authors: Sánchez-Antequera, Y;Mykhaylyk, O;van Til, NP;Cengizeroglu, A;de Jong, JH;Huston, MW;Anton, M;Johnston, IC;Pojda, Z;Wagemaker, G;Plank, C

Year: 2011

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1073080

Thesis Development of plasmid-based expression technology for rapid and sustained production of recombinant proteins in insect cells

Shen, Xiao · 2014 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Development of plasmid-based expression technology for rapid and sustained production of recombinant proteins in insect cells

Authors: Shen, Xiao

Year: 2014

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/109165

Thesis Lentiviral and Adeno-Associated Vector-Based Therapy for Motor Neuron Disease Through RNAi

Towne, C.; Aebischer, P · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Lentiviral and Adeno-Associated Vector-Based Therapy for Motor Neuron Disease Through RNAi

Authors: Towne, C.; Aebischer, P

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/40383

Thesis Systematic insights into cell density-dependent transcriptional responses upon medium replacements

Pérez-Rubio, Pol; Romero, Elianet Lorenzo; Cervera, Laura et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Systematic insights into cell density-dependent transcriptional responses upon medium replacements

Authors: Pérez-Rubio, Pol; Romero, Elianet Lorenzo; Cervera, Laura; Gòdia, Francesc; Nielsen, Lars Keld; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2c104764-6292-43ba-8eaf-c03af53bbcf2

Thesis Optimization of chemically defined cell culture media: Replacing fetal bovine serum in mammalian in vitro methods

van der Valk, J.B.F.; Brunner, D.; De Smet, K. et al. · 2010 · Utrecht University · DOI

Full title: Optimization of chemically defined cell culture media: Replacing fetal bovine serum in mammalian in vitro methods

Authors: van der Valk, J.B.F.; Brunner, D.; De Smet, K.; Fex Svenningsen, Å.; Honegger, P.; Knudsen, L.E.; Lindl, T.; Noraberg, J.; Price, A.; Scarino, M.L.; Gstraunthaler, G.

Year: 2010

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/191398

Thesis Magnetic nanoparticle and magnetic field assisted siRNA delivery in vitro.

Mykhaylyk, Olga; Sanchez-Antequera, Yolanda; Vlaskou, Dialechti et al. · 2015 · Technical University of Munich (TUM) · DOI

Full title: Magnetic nanoparticle and magnetic field assisted siRNA delivery in vitro.

Authors: Mykhaylyk, Olga;Sanchez-Antequera, Yolanda;Vlaskou, Dialechti;Cerda, Maria Belen;Bokharaei, Mehrdad;Hammerschmid, Edelburga;Anton, Martina;Plank, Christian

Year: 2015

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1321594

Thesis Liposomal magnetofection.

Mykhaylyk, O; Sánchez-Antequera, Y; Vlaskou, D et al. · 2010 · Technical University of Munich (TUM) · DOI

Full title: Liposomal magnetofection.

Authors: Mykhaylyk, O;Sánchez-Antequera, Y;Vlaskou, D;Hammerschmid, E;Anton, M;Zelphati, O;Plank, C

Year: 2010

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1073056

Thesis A simple and highly effective method for the stable transduction of uncultured porcine hepatocytes using lentiviral vector

Nguyen, T. H.; Khakhoulina, T.; Simmons, A. et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A simple and highly effective method for the stable transduction of uncultured porcine hepatocytes using lentiviral vector

Authors: Nguyen, T. H.; Khakhoulina, T.; Simmons, A.; Morel, P.; Trono, Didier

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/50927

Thesis Valproic acid enhances recombinant mRNA and protein levels in transiently transfected Chinese hamster ovary cells

Wulhfard, Sarah; Baldi, Lucia; Hacker, David L. et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Valproic acid enhances recombinant mRNA and protein levels in transiently transfected Chinese hamster ovary cells

Authors: Wulhfard, Sarah; Baldi, Lucia; Hacker, David L.; Wurm, Florian

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/52514

Thesis Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector.

Merkl, Claudia; Saalfrank, Anja; Riesen, Nathalie et al. · 2013 · Technical University of Munich (TUM) · DOI

Full title: Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector.

Authors: Merkl, Claudia;Saalfrank, Anja;Riesen, Nathalie;Kühn, Ralf;Pertek, Anna;Eser, Stefan;Hardt, Markus Sebastian;Kind, Alexander;Saur, Dieter;Wurst, Wolfgang;Iglesias, Antonio;Schnieke, Angelika

Year: 2013

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1211164

Thesis A stable system for the high-titer production of multiply attenuated lentiviral vectors

Klages, N; Zufferey, R; Trono, Didier · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A stable system for the high-titer production of multiply attenuated lentiviral vectors

Authors: Klages, N; Zufferey, R; Trono, Didier

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/215862

Thesis ESTABLISHMENT AND UTILIZATION OF DUAL-COLOR REPORTER MODELS FOR IMPROVING GENE THERAPY AND GENE EDITING STRATEGIES

Weber, Jesse, Andrew · 2024 · University of Pennsylvania · DOI

Full title: ESTABLISHMENT AND UTILIZATION OF DUAL-COLOR REPORTER MODELS FOR IMPROVING GENE THERAPY AND GENE EDITING STRATEGIES

Authors: Weber, Jesse, Andrew

Year: 2024

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/60101

Thesis Large-scale transient expression in mammalian cells for recombinant protein production

Wurm, F.; Bernard, A. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Large-scale transient expression in mammalian cells for recombinant protein production

Authors: Wurm, F.; Bernard, A.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7633

Thesis Generation of magnetic nonviral gene transfer agents and magnetofection in vitro.

Mykhaylyk, O; Antequera, YS; Vlaskou, D et al. · 2007 · Technical University of Munich (TUM) · DOI

Full title: Generation of magnetic nonviral gene transfer agents and magnetofection in vitro.

Authors: Mykhaylyk, O;Antequera, YS;Vlaskou, D;Plank, C

Year: 2007

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/674887

Thesis 100-liter transient transfection

Girard, P; Derouazi, M; Baumgartner, G et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: 100-liter transient transfection

Authors: Girard, P; Derouazi, M; Baumgartner, G; Bourgeois, M; Jordan, M; Jacko, B; Wurm, FM

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41396

Thesis Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Hansen, Henning Gram; Nilsson, Claes Nymand; Lund, Anne Mathilde et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Authors: Hansen, Henning Gram; Nilsson, Claes Nymand; Lund, Anne Mathilde; Kol, Stefan; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lundqvist, Magnus; Rockberg, Johan; Min Lee, Gyun; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/41719bc3-f624-40be-ba5e-4449c22aac7f

Thesis Navigating biomanufacturing challenges in the use of CHO cells for recombinant adeno-associated virus production

Tatjer, David Catalán; id_orcid 0000-0002-0900-9912 · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Navigating biomanufacturing challenges in the use of CHO cells for recombinant adeno-associated virus production

Authors: Tatjer, David Catalán; id_orcid 0000-0002-0900-9912

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9209d5ce-66e5-452d-9d20-a94da77a0102

Thesis mRNA Delivery and Storage by Co-Assembling Nanostructures with Designer Oligopeptides

Feng, Ruilu; Chang, Atta Cheuk Yan; Ni, Rong et al. · 2022 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: mRNA Delivery and Storage by Co-Assembling Nanostructures with Designer Oligopeptides

Authors: Feng, Ruilu; Chang, Atta Cheuk Yan; Ni, Rong; Li, Jacky Cheuk Yin; Chau, Ying

Year: 2022

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-119181

Thesis Guide to Electroporation and Electrofusion

Chang, Donald Choy LIFS; Saunders, James A.; Chassy, Bruce M. et al. · 2012 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Guide to Electroporation and Electrofusion

Authors: Chang, Donald Choy LIFS; Saunders, James A.; Chassy, Bruce M.; Sowers, Arthur E.

Year: 2012

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-100345

Thesis Transient expression of rabies virus G-glycoprotein using BHK-21 cells cultured in suspension

Nuñez, Eutimio Gustavo Fernández [UNESP]; De Rezende, Alexandre GonÇalves; Puglia, Ana Lia Pradella et al. · 2015 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Transient expression of rabies virus G-glycoprotein using BHK-21 cells cultured in suspension

Authors: Nuñez, Eutimio Gustavo Fernández [UNESP]; De Rezende, Alexandre GonÇalves; Puglia, Ana Lia Pradella; Leme, Jaci; Boldorini, Vera Lucia Lopes; Caricati, Celso Pereira; Tonso, Aldo

Year: 2015

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://link.springer.com/article/10.1007%2Fs10529-015-1787-3

Thesis Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells.

Rudolph, C; Plank, C; Lausier, J et al. · 2003 · Technical University of Munich (TUM) · DOI

Full title: Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells.

Authors: Rudolph, C;Plank, C;Lausier, J;Schillinger, U;Müller, RH;Rosenecker, J

Year: 2003

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1330223

Thesis S-phase synchronized CHO cells show elevated transfection efficiency and expression using CaPi

Grosjean, F; Batard, P; Jordan, M et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: S-phase synchronized CHO cells show elevated transfection efficiency and expression using CaPi

Authors: Grosjean, F; Batard, P; Jordan, M; Wurm, FM

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41385

Thesis S-phase synchronized CHO cells show elevated transfection efficiency and expression using Ca/PO4

Grosjean, F.; Batard, P; Jordan, M. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: S-phase synchronized CHO cells show elevated transfection efficiency and expression using Ca/PO4

Authors: Grosjean, F.; Batard, P; Jordan, M.; Wurm, F.M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9734

Thesis Uncertainty quantification for gene delivery methods: a roadmap for pDNA manufacturing from phase I clinical trials to commercialization

Triantafyllou, Niki; Sarkis, Miriam; Krassakopoulou, Aikaterina et al. · 2024 · Imperial College London · DOI

Full title: Uncertainty quantification for gene delivery methods: a roadmap for pDNA manufacturing from phase I clinical trials to commercialization

Authors: Triantafyllou, Niki; Sarkis, Miriam; Krassakopoulou, Aikaterina; Shah, Nilay; Papathanasiou, Maria M; Kontoravdi, Cleo

Year: 2024

Venue: Imperial College London

DOI: http://dx.doi.org/10.1002/biot.202300103

Thesis Magnetofection to enhance transfection efficiency of large genomic context vectors in vitro

Xenariou, S; Griesenbach, U; Bowden, R et al. · 2004 · Technical University of Munich (TUM) · DOI

Full title: Magnetofection to enhance transfection efficiency of large genomic context vectors in vitro

Authors: Xenariou, S;Griesenbach, U;Bowden, R;Hillery, E;Doherty, A;Geddes, D;Porteous, D;Plank, C;Alton, E;Boyd, AC

Year: 2004

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1330290

Thesis Unlocking DOE potential by selecting the most appropriate design for rAAV optimization

Tzimou, Konstantina; Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Unlocking DOE potential by selecting the most appropriate design for rAAV optimization

Authors: Tzimou, Konstantina; Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Nielsen, Lars K.; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bcce91f5-d977-47e8-a623-e02bd6425a16

Thesis Calcium phosphate transfection optimization for serum-free suspension culture

Girard, P.; Porte, L.; Berta, T. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Calcium phosphate transfection optimization for serum-free suspension culture

Authors: Girard, P.; Porte, L.; Berta, T.; Jordan, M.; Wurm, F.M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9728

Thesis Polyethylenimine-mediated transient transfectionn of CHO cells in conditioned medium

Duhr, Ralph · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Polyethylenimine-mediated transient transfectionn of CHO cells in conditioned medium

Authors: Duhr, Ralph

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/44140

Thesis Novel Approaches for Pluripotent Reprogramming

Weltner, Jere · 2018 · University of Helsinki (HELDA) · DOI

Full title: Novel Approaches for Pluripotent Reprogramming

Authors: Weltner, Jere

Year: 2018

Venue: University of Helsinki (HELDA)

DOI: http://hdl.handle.net/10138/237188

Thesis A strategy to establish a gene-activated matrix on titanium using gene vectors protected in a polylactide coating.

Kolk, A; Haczek, C; Koch, C et al. · 2011 · Technical University of Munich (TUM) · DOI

Full title: A strategy to establish a gene-activated matrix on titanium using gene vectors protected in a polylactide coating.

Authors: Kolk, A;Haczek, C;Koch, C;Vogt, S;Kullmer, M;Pautke, C;Deppe, H;Plank, C

Year: 2011

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1100141

Thesis A microfluidics-based paradigm for clinical lentivector gene transfer

Tran, Reginald · 2018 · Georgia Institute of Technology · DOI

Full title: A microfluidics-based paradigm for clinical lentivector gene transfer

Authors: Tran, Reginald

Year: 2018

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/59163

Thesis Coexpression of acidic fibroblast growth factor enhances specific productivity and antibody titers in transiently transfected HEK293 cells

Backliwal, G; Hildinger, M; Chenuet, S et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Coexpression of acidic fibroblast growth factor enhances specific productivity and antibody titers in transiently transfected HEK293 cells

Authors: Backliwal, G; Hildinger, M; Chenuet, S; Dejesus, M; Wurm, FM

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41397

Thesis Application of aqueous two-phase micellar system to improve extraction of adenoviral particles from cell lysate

Dutra Molino, Joao Vitor; Lopes, Andre Moreni [UNESP]; Viana Marques, Daniela de Araujo et al. · 2018 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Application of aqueous two-phase micellar system to improve extraction of adenoviral particles from cell lysate

Authors: Dutra Molino, Joao Vitor; Lopes, Andre Moreni [UNESP]; Viana Marques, Daniela de Araujo; Mazzola, Priscila Gava; Silva, Joas Lucas da; Hirata, Mario Hiroyuki; Crespo Hirata, Rosario Dominguez; Viccari Gatti, Maria Silvia; Pessoa, Adalberto

Year: 2018

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1002/bab.1627

Thesis The impact of physical and biological factors on intracellular uptake, trafficking and gene transfection after ultrasound exposure

Liu, Ying · 2012 · Georgia Institute of Technology · DOI

Full title: The impact of physical and biological factors on intracellular uptake, trafficking and gene transfection after ultrasound exposure

Authors: Liu, Ying

Year: 2012

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/43626

Thesis Development of high-titer transient gene expression processes for manufacturing recombinant proteins

Backliwal, Gaurav · 2008 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Development of high-titer transient gene expression processes for manufacturing recombinant proteins

Authors: Backliwal, Gaurav

Year: 2008

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/26414

Thesis Transient gene expression in suspension HEK-293 cells: application to large-scale protein production

Baldi, L.; Muller, N.; Picasso, S. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transient gene expression in suspension HEK-293 cells: application to large-scale protein production

Authors: Baldi, L.; Muller, N.; Picasso, S.; Jacquet, R.; Girard, P.; Thanh, H. P.; Derow, E.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7668

Thesis Nonviral vector loaded collagen sponges for sustained gene delivery in vitro and in vivo.

Scherer, F; Schillinger, U; Putz, U et al. · 2002 · Technical University of Munich (TUM) · DOI

Full title: Nonviral vector loaded collagen sponges for sustained gene delivery in vitro and in vivo.

Authors: Scherer, F;Schillinger, U;Putz, U;Stemberger, A;Plank, C

Year: 2002

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1330194

Thesis Productive replication of adeno-associated virus can occur in human papillomavirus type 16 (HPV-16) episome-containing keratinocytes and is augmented by the HPV-16 E2 protein

Ogston, P.; Raj, K.; Beard, P. · 2008 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Productive replication of adeno-associated virus can occur in human papillomavirus type 16 (HPV-16) episome-containing keratinocytes and is augmented by the HPV-16 E2 protein

Authors: Ogston, P.; Raj, K.; Beard, P.

Year: 2008

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/17444

Thesis Establishing the Proof-of-Concept for Hematopoietic Stem Cell-Directed Gene Therapy via Gene Editing Strategies for the Treatment of Ataxia-Telangiectasia

Sartre, Gilles Marie · 2025 · Vetsuisse Faculty Bern and Zurich · DOI

Full title: Establishing the Proof-of-Concept for Hematopoietic Stem Cell-Directed Gene Therapy via Gene Editing Strategies for the Treatment of Ataxia-Telangiectasia

Authors: Sartre, Gilles Marie

Year: 2025

Venue: Vetsuisse Faculty Bern and Zurich

DOI: oai:www.zora.uzh.ch:20.500.14742/237626

Thesis Unlocking DOE potential by selecting the most appropriate design for rAAV optimization

Tzimou, Konstantina; Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Unlocking DOE potential by selecting the most appropriate design for rAAV optimization

Authors: Tzimou, Konstantina; Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Nielsen, Lars K.; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bcce91f5-d977-47e8-a623-e02bd6425a16

Thesis The Use of Enhanced Green Fluorescent Protein-Expressing Cell-Based Platform for Cancer Drug Screening

Sajid, Sameeha · 2019 · The Ohio State University · DOI

Full title: The Use of Enhanced Green Fluorescent Protein-Expressing Cell-Based Platform for Cancer Drug Screening

Authors: Sajid, Sameeha

Year: 2019

Venue: The Ohio State University

DOI: http://hdl.handle.net/1811/87586

Thesis Optimization of a process for high-yield lentiviral vector production applied to car-t cell generation

Souza, Lucas Eduardo Botelho de · 2020 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Optimization of a process for high-yield lentiviral vector production applied to car-t cell generation

Authors: Souza, Lucas Eduardo Botelho de

Year: 2020

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.1016/j.htct.2020.10.709

Thesis Understanding mammalian cell metabolism and developing cell culture strategies for enhanced manufacturing of biotherapeutics

Ladiwala, Pranay · 2025 · Johns Hopkins University · DOI

Full title: Understanding mammalian cell metabolism and developing cell culture strategies for enhanced manufacturing of biotherapeutics

Authors: Ladiwala, Pranay

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70273

Thesis Successful Transfection of Partially Purified DNA in the HEK293EBNA Cell Line for Transient Expression

Wright, J.L.; Jordan, M.; Wurm, F.M. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Successful Transfection of Partially Purified DNA in the HEK293EBNA Cell Line for Transient Expression

Authors: Wright, J.L.; Jordan, M.; Wurm, F.M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9730

Thesis An Adeno-Associated Virus-Based Intracellular Sensor of Pathological Nuclear Factor-kappa B Activation for Disease-Inducible Gene Transfer

Chtarto, Abdelwahed; Bockstael, Olivier; Gebara, Elias et al. · 2013 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: An Adeno-Associated Virus-Based Intracellular Sensor of Pathological Nuclear Factor-kappa B Activation for Disease-Inducible Gene Transfer

Authors: Chtarto, Abdelwahed; Bockstael, Olivier; Gebara, Elias; Vermoesen, Katia; Melas, Catherine; Pythoud, Catherine; Levivier, Marc; De Witte, Olivier; Luthi-Carter, Ruth; Clinkers, Ralph; Tenenbaum, Liliane

Year: 2013

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/91645

Thesis Application of pulsed magnetic field enhances non-viral gene delivery in primary cells from different origins

Kamau Chapman, S W; Hassa, P O; Koch-Schneidemann, S et al. · 2008 · Vetsuisse Faculty Bern and Zurich · DOI

Full title: Application of pulsed magnetic field enhances non-viral gene delivery in primary cells from different origins

Authors: Kamau Chapman, S W; Hassa, P O; Koch-Schneidemann, S; von Rechenberg, Brigitte; https://orcid.org/0000-0002-3836-6812; Hofmann-Amtenbrink, M; Steitz, B; Petri-Fink, A; Hofmann, H; Hottiger, Michael O; https://orcid.org/0000-0002-7323-2270

Year: 2008

Venue: Vetsuisse Faculty Bern and Zurich

DOI: oai:www.zora.uzh.ch:20.500.14742/40137

Thesis Two strategies to improve transient gene expression in HEK293E and/or CHO-DG44 cells

Lüthi, Guillaume · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Two strategies to improve transient gene expression in HEK293E and/or CHO-DG44 cells

Authors: Lüthi, Guillaume

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76255

Thesis Methods for in vivo CRISPR/cas editing of the adult murine retina

Hung, SS; Li, F; Wang, JH et al. · 2022 · University of Melbourne · DOI

Full title: Methods for in vivo CRISPR/cas editing of the adult murine retina

Authors: Hung, SS; Li, F; Wang, JH; King, AE; Bui, BV; Liu, GS; Hewitt, AW

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/306406

Thesis Self-assembling poly(L-lysine)/DNA complexes capable of integrin- mediated cellular uptake and gene expression

Carlisle, Robert C.; Read, Martin L.; Wolfert, Margreet A. et al. · 1999 · Utrecht University · DOI

Full title: Self-assembling poly(L-lysine)/DNA complexes capable of integrin- mediated cellular uptake and gene expression

Authors: Carlisle, Robert C.; Read, Martin L.; Wolfert, Margreet A.; Seymour, Leonard W.

Year: 1999

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/387153

Thesis MG53 AAV Constructs as a Gene Therapy for Dysferlinopathies

Kern, Benjamen · 2024 · The Ohio State University · DOI

Full title: MG53 AAV Constructs as a Gene Therapy for Dysferlinopathies

Authors: Kern, Benjamen

Year: 2024

Venue: The Ohio State University

DOI: https://kb.osu.edu/handle/1811/104305

Thesis Minicircle mediated gene delivery to canine and equine mesenchymal stem cells

Tidd, Naomie; Michelsen, Jacob; Hilbert, Bryan et al. · 2017 · Charles Sturt University - Research Output · DOI

Full title: Minicircle mediated gene delivery to canine and equine mesenchymal stem cells

Authors: Tidd, Naomie; Michelsen, Jacob; Hilbert, Bryan; Quinn, Jane C.; id_orcid 0000-0002-9310-0291

Year: 2017

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/90e70eeb-5b16-4ca1-b136-aa86be060343

Thesis Designing Targeted Biological Tools to Study Musculoskeletal Diseases

O'Donohue, Alexandra Kathleen · 2023 · University of Sydney · DOI

Full title: Designing Targeted Biological Tools to Study Musculoskeletal Diseases

Authors: O'Donohue, Alexandra Kathleen

Year: 2023

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/30119

Thesis Hurdles to healing: Overcoming cellular barriers for viral and nonviral gene therapy

Honrath, Steffen; id_orcid0009-0003-7513-8872; Burger, Michael et al. · 2025 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Hurdles to healing: Overcoming cellular barriers for viral and nonviral gene therapy

Authors: Honrath, Steffen; id_orcid0009-0003-7513-8872; Burger, Michael; Leroux, Jean-Christophe; id_orcid0009-0003-7513-8872

Year: 2025

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/729457

Thesis Lentiviral-mediated gene transfer to model triplet repeat disorders

Regulier, E.; Zala, D.; Aebischer, P. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Lentiviral-mediated gene transfer to model triplet repeat disorders

Authors: Regulier, E.; Zala, D.; Aebischer, P.; Deglon, N.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/3772

Thesis Innate Immune Suppression Enables Frequent Transfection with RNA Encoding Reprogramming Proteins

Angel, Matthew; Yanik, Mehmet F. · 2010 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Innate Immune Suppression Enables Frequent Transfection with RNA Encoding Reprogramming Proteins

Authors: Angel, Matthew; Yanik, Mehmet F.

Year: 2010

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/107587

Thesis Safe delivery of AAV vectors to the liver of small weaned pigs by ultrasound-guided percutaneous transhepatic portal vein injection

Rothgangl, Tanja; https://orcid.org/0000-0001-7799-2413; Hruzova, Martina et al. · 2023 · Vetsuisse Faculty Bern and Zurich · DOI

Full title: Safe delivery of AAV vectors to the liver of small weaned pigs by ultrasound-guided percutaneous transhepatic portal vein injection

Authors: Rothgangl, Tanja; https://orcid.org/0000-0001-7799-2413; Hruzova, Martina; Gnannt, Ralph; https://orcid.org/0000-0001-8120-6200; Aeberhard, Nadja; Kissling, Lucas; https://orcid.org/0000-0002-4989-0695; Grisch-Chan, Hiu Man; Klassa, Sven; Rimann, Nicole; Marquart, Kim F; https://orcid.org/0000-0001-7393-4398; Ioannidi, Eleonora; https://orcid.org/0000-0001-7964-7744; Wolf, Anja; Kupatt, Christian; Sidler, Xaver; Häberle, Johannes; https://orcid.org/0000-0003-0635-091X; Schwank, Gerald; https://orcid.org/0000-0003-0767-2953; Thöny, Beat; https://orcid.org/0000-0002-5001-086X

Year: 2023

Venue: Vetsuisse Faculty Bern and Zurich

DOI: oai:www.zora.uzh.ch:20.500.14742/214740

Thesis Overexpression of RasV12 and its role in promoting the robustness of HEK293T cells.

Chow, Peiyi Vicki. · 2013 · Nanyang Technological University (NTU) · DOI

Full title: Overexpression of RasV12 and its role in promoting the robustness of HEK293T cells.

Authors: Chow, Peiyi Vicki.

Year: 2013

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/52745

Thesis Rekombinante Adeno-assoziierte Viren zur Expression des µ-Opioid-Rezeptors in neuronalen Zellen

Abbarin, Mehrnousch · 2010 · Freie Universität Berlin (Refubium) · DOI

Full title: Rekombinante Adeno-assoziierte Viren zur Expression des µ-Opioid-Rezeptors in neuronalen Zellen

Authors: Abbarin, Mehrnousch

Year: 2010

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/7311

Thesis Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Hansen, Henning Gram; Nilsson, Claes Nymand; Lund, Anne Mathilde et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/41719bc3-f624-40be-ba5e-4449c22aac7f

Thesis Evolution from adherent to suspension: systems biology of HEK293 cell line development

Malm, Magdalena; Saghaleyni, Rasool; Lundqvist, Magnus et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Evolution from adherent to suspension: systems biology of HEK293 cell line development

Authors: Malm, Magdalena; Saghaleyni, Rasool; Lundqvist, Magnus; Giudici, Marco; Chotteau, Veronique; Field, Ray; Varley, Paul G.; Hatton, Diane; Grassi, Luigi; Svensson, Thomas; Nielsen, Jens; Rockberg, Johan

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ac719809-b95e-40e0-85c8-5c0a28c5bd85

Thesis Gene therapy using viral vector against anxiety

Loo, Sze Jie · 2016 · Nanyang Technological University (NTU) · DOI

Full title: Gene therapy using viral vector against anxiety

Authors: Loo, Sze Jie

Year: 2016

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/67358

Thesis A simple high-yielding process for transient gene expression in CHO cells

Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia et al. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A simple high-yielding process for transient gene expression in CHO cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/70206

Thesis Enhancing recombinant adeno-associated virus (rAAV) production through cell and gene engineering

Bosch Molist, Laia · 2024 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Enhancing recombinant adeno-associated virus (rAAV) production through cell and gene engineering

Authors: Bosch Molist, Laia

Year: 2024

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/692000

Thesis Modified microplex vector enhances transfection of cells in culture while maintaining tumor-selective gene delivery in-vivo

Dass, Crispin; Burton, Mark · 2003 · Charles Sturt University - Research Output · DOI

Full title: Modified microplex vector enhances transfection of cells in culture while maintaining tumor-selective gene delivery in-vivo

Authors: Dass, Crispin; Burton, Mark

Year: 2003

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/5c5a51a3-a5ab-4f96-af54-cc662756e59f

Thesis Enhancement of lentiviral vector production through alteration of virus-cell interactions

Gelinas, J · 2016 · University of Oxford - ORA · DOI

Full title: Enhancement of lentiviral vector production through alteration of virus-cell interactions

Authors: Gelinas, J

Year: 2016

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:9921b8b4-e2b5-4eec-9efc-6036765c8d55

Thesis Lentiviral Vector-Mediated Gene Delivery for the Generation of Chinese Hamster Ovary Cell Lines with Improved Productivity and Stability

Oberbek, Agata · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Lentiviral Vector-Mediated Gene Delivery for the Generation of Chinese Hamster Ovary Cell Lines with Improved Productivity and Stability

Authors: Oberbek, Agata

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/52293

Thesis Calfection: a novel gene transfer method for suspension cells

Lindell, J.; Girard, P.; Muller, N. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Calfection: a novel gene transfer method for suspension cells

Authors: Lindell, J.; Girard, P.; Muller, N.; Jordan, M.; Wurm, F.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7624

Thesis Transfection of primary brain capillary endothelial cells for protein synthesis and secretion of recombinant erythropoietin: a strategy to enable protein delivery to the brain

Burkhart, Annette; Andresen, Thomas Lars; id_orcid 0000-0002-1048-127X et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Transfection of primary brain capillary endothelial cells for protein synthesis and secretion of recombinant erythropoietin: a strategy to enable protein delivery to the brain

Authors: Burkhart, Annette; Andresen, Thomas Lars; id_orcid 0000-0002-1048-127X; Aigner, Achim; Thomsen, Louiza Bohn; Moos, Torben

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ea34253f-c646-4f1a-a9ac-cd8769c8bb27

Thesis Rapid recombinant protein production from piggyBac transposon-mediated stable CHO cell pools

Balasubramanian, Sowmya; Matasci, Mattia; Kadlecova, Zuzana et al. · 2015 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Rapid recombinant protein production from piggyBac transposon-mediated stable CHO cell pools

Authors: Balasubramanian, Sowmya; Matasci, Mattia; Kadlecova, Zuzana; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2015

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/113975

Thesis Recombinant adeno-associated virus type 2-mediated gene transfer into human keratinocytes is influenced by both the ubiquitin/proteasome pathway and epidermal growth factor receptor tyrosine kinase.

Braun-Falco, M; Eisenried, A; Büning, H et al. · 2005 · Technical University of Munich (TUM) · DOI

Full title: Recombinant adeno-associated virus type 2-mediated gene transfer into human keratinocytes is influenced by both the ubiquitin/proteasome pathway and epidermal growth factor receptor tyrosine kinase.

Authors: Braun-Falco, M;Eisenried, A;Büning, H;Ring, J

Year: 2005

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1329981

Thesis Scalable, Serum-free, High Efficiency Transfection of CHO Cells using an Economical DNA Transfer Vehicle

Girard, P.; Derouazi, M.; Wurm, F.M. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Scalable, Serum-free, High Efficiency Transfection of CHO Cells using an Economical DNA Transfer Vehicle

Authors: Girard, P.; Derouazi, M.; Wurm, F.M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7636

Thesis 携带CML28基因的2型重组腺相关病毒的构建及体外转染树突状细胞

解麗華; 冼韻儀; 謝雍 · 2009 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: 携带CML28基因的2型重组腺相关病毒的构建及体外转染树突状细胞

Authors: 解麗華; 冼韻儀; 謝雍

Year: 2009

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-17515

Thesis A novel expression and purification system for the production of enzymatic and biologically active human granzyme B.

Gehrmann, M; Doss, BT; Wagner, M et al. · 2011 · Technical University of Munich (TUM) · DOI

Full title: A novel expression and purification system for the production of enzymatic and biologically active human granzyme B.

Authors: Gehrmann, M;Doss, BT;Wagner, M;Zettlitz, KA;Kontermann, RE;Foulds, G;Pockley, AG;Multhoff, G

Year: 2011

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1100189

Thesis Strategies to facilitate the long-term expression of transgenes for treatment of chronic liver disease

van Haasteren, J · 2019 · University of Oxford - ORA · DOI

Full title: Strategies to facilitate the long-term expression of transgenes for treatment of chronic liver disease

Authors: van Haasteren, J

Year: 2019

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:89545b9b-6ed5-4a78-9232-c0a645d7ee67

Thesis Virus-free transient protein production in Sf9 cells

Shen, Xiao; Hacker, David L.; Baldi, Lucia et al. · 2014 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Virus-free transient protein production in Sf9 cells

Authors: Shen, Xiao; Hacker, David L.; Baldi, Lucia; Wurm, Florian M.

Year: 2014

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/102401

Thesis Optimizing Adenoviral Transduction of Endothelial Cells under Flow Conditions.

Anton, M; Wolf, A; Mykhaylyk, O et al. · 2012 · Technical University of Munich (TUM) · DOI

Full title: Optimizing Adenoviral Transduction of Endothelial Cells under Flow Conditions.

Authors: Anton, M;Wolf, A;Mykhaylyk, O;Koch, C;Gansbacher, B;Plank, C

Year: 2012

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1181340

Thesis Plasmid-based electroporation for efficient genetic engineering in immortalized T lymphocytes

Xie, Yu-Qing; Fussenegger, Martin; id_orcid0000-0001-8545-667X · 2025 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Plasmid-based electroporation for efficient genetic engineering in immortalized T lymphocytes

Authors: Xie, Yu-Qing; Fussenegger, Martin; id_orcid0000-0001-8545-667X

Year: 2025

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/731909

Thesis Accelerating the development time of recombinant mammalian cell lines producing high titers of protein therapeutics

Chenuet, Sébastien · 2008 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Accelerating the development time of recombinant mammalian cell lines producing high titers of protein therapeutics

Authors: Chenuet, Sébastien

Year: 2008

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/25783

Thesis Role of non-specific DNA in reducing coding DNA requirement for transient gene expression with CHO and HEK-293E cells

Rajendra, Yashas; Kiseljak, Divor; Manoli, Sagar et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Role of non-specific DNA in reducing coding DNA requirement for transient gene expression with CHO and HEK-293E cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Manoli, Sagar; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/82394

Thesis Optimized Lentiviral Transduction Protocols by Use of a Poloxamer Enhancer, Spinoculation, and scFv-Antibody Fusions to VSV-G.

Anastasov, Nata?a; Höfig, Ines; Mall, Sabine et al. · 2016 · Technical University of Munich (TUM) · DOI

Full title: Optimized Lentiviral Transduction Protocols by Use of a Poloxamer Enhancer, Spinoculation, and scFv-Antibody Fusions to VSV-G.

Authors: Anastasov, Nata?a;Höfig, Ines;Mall, Sabine;Krackhardt, Angela M;Thirion, Christian

Year: 2016

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1360687

Thesis Mechanistic Model for Production of Recombinant Adeno-associated Virus via Triple Transfection of HEK293 Cells

Nguyen, Tam NT; Sha, Sha; Hong, Moo Sun et al. · 2021 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Mechanistic Model for Production of Recombinant Adeno-associated Virus via Triple Transfection of HEK293 Cells

Authors: Nguyen, Tam NT; Sha, Sha; Hong, Moo Sun; Maloney, Andrew J; Barone, Paul W; Neufeld, Caleb; Wolfrum, Jacqueline; Springs, Stacy L; Sinskey, Anthony J; Braatz, Richard D

Year: 2021

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/135559

Thesis Improved transfection efficiency and metabolic activity in human embryonic stem cell using non-enzymatic method

Kim, C-Yoon; Hwang, In-Kyu; Kang, Changhee et al. · 2023 · Seoul National University · DOI

Full title: Improved transfection efficiency and metabolic activity in human embryonic stem cell using non-enzymatic method

Authors: Kim, C-Yoon; Hwang, In-Kyu; Kang, Changhee; Chung, Eun-Bin; Jung, Cho-Rok; Oh, Hanseul; Jeong, Young-Hoon; Moon, Sung-Hwan; Kim, Jong Soo; Hong, Ki-Sung; Park, Jae-Hak; Chung, Hyung-Min

Year: 2023

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/194756

Thesis Viral Vectors for Gene Therapy, Cancer, and SARS-CoV-2

Dagotto, Gabriel · 2024 · Harvard University - DASH · DOI

Full title: Viral Vectors for Gene Therapy, Cancer, and SARS-CoV-2

Authors: Dagotto, Gabriel

Year: 2024

Venue: Harvard University - DASH

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37378755

Thesis Unravelling the essential elements for recombinant adeno-associated virus (rAAV) production in animal cell-based platforms

Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Tzimou, Konstantina et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Unravelling the essential elements for recombinant adeno-associated virus (rAAV) production in animal cell-based platforms

Authors: Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Tzimou, Konstantina; Nielsen, Lars K.; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/00e28410-d986-4a71-bcb4-7e64bcd223a2

Thesis Poly(ethyleneimine)-Mediated Large-Scale Transient Gene Expression: Influence of Molecular Weight, Polydispersity and N-Propionyl Groups

Kadlecova, Zuzana; Nallet, Sophie; Hacker, David L. et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Poly(ethyleneimine)-Mediated Large-Scale Transient Gene Expression: Influence of Molecular Weight, Polydispersity and N-Propionyl Groups

Authors: Kadlecova, Zuzana; Nallet, Sophie; Hacker, David L.; Baldi, Lucia; Klok, Harm-Anton; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/81225

Thesis Progress in the Use of Adeno-Associated Viral Vectors for Gene Therapy

Büning, Hildegard; Braun-Falco, Markus; Hallek, Michael · 2004 · Technical University of Munich (TUM) · DOI

Full title: Progress in the Use of Adeno-Associated Viral Vectors for Gene Therapy

Authors: Büning, Hildegard;Braun-Falco, Markus;Hallek, Michael

Year: 2004

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1218804

Thesis Evolution from adherent to suspension: systems biology of HEK293 cell line development

Malm, Magdalena; Saghaleyni, Rasool; Lundqvist, Magnus et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Evolution from adherent to suspension: systems biology of HEK293 cell line development

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ac719809-b95e-40e0-85c8-5c0a28c5bd85

Thesis Magnetofection potentiates gene delivery to cultured endothelial cells.

Krötz, F; Sohn, HY; Gloe, T et al. · 2003 · Technical University of Munich (TUM) · DOI

Full title: Magnetofection potentiates gene delivery to cultured endothelial cells.

Authors: Krötz, F;Sohn, HY;Gloe, T;Plank, C;Pohl, U

Year: 2003

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1330225

Thesis Mild hypothermia improves transient gene expression yields several fold in Chinese hamster ovary cells

Wulhfard, S; Tissot, S; Bouchet, S et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Mild hypothermia improves transient gene expression yields several fold in Chinese hamster ovary cells

Authors: Wulhfard, S; Tissot, S; Bouchet, S; Cevey, J; De Jesus, M; Hacker, DL; Wurm, FM

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41413

Thesis BMP2 gene delivery mediated by chitosan-ss-PEI non-viral vector and investigation of BMP2 signaling regulation

Zhao, Xiaoli; 赵晓丽 · 2012 · University of Hong Kong · DOI

Full title: BMP2 gene delivery mediated by chitosan-ss-PEI non-viral vector and investigation of BMP2 signaling regulation

Authors: Zhao, Xiaoli; 赵晓丽

Year: 2012

Venue: University of Hong Kong

DOI: https://hub.hku.hk/handle/10722/146135

Thesis Single-Cell Impedance Cytometry for the Control of Single-Cell Electroporation in a Flow-Through Device

Rudge, Josiah · 2025 · Georgia Institute of Technology · DOI

Full title: Single-Cell Impedance Cytometry for the Control of Single-Cell Electroporation in a Flow-Through Device

Authors: Rudge, Josiah

Year: 2025

Venue: Georgia Institute of Technology

DOI: https://hdl.handle.net/1853/77892

Thesis Low-temperature pausing of cultivated mammalian cells

Hunt, L.; Hacker, D. L.; Grosjean, F. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Low-temperature pausing of cultivated mammalian cells

Authors: Hunt, L.; Hacker, D. L.; Grosjean, F.; De Jesus, M.; Uebersax, L.; Jordan, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9752

Thesis Transfection of adherent and suspended cells by calcium phosphate

Jordan, M.; Wurm, F. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transfection of adherent and suspended cells by calcium phosphate

Authors: Jordan, M.; Wurm, F.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7665

Thesis A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

Lund, Anne Mathilde; Kildegaard, Helene Faustrup; Petersen, Maja Borup Kjær et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

Authors: Lund, Anne Mathilde; Kildegaard, Helene Faustrup; Petersen, Maja Borup Kjær; Rank, Julie; Hansen, Bjarne Gram; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Mortensen, Uffe Hasbro; id_orcid 0000-0002-7794-7273

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1e6b9cdd-536a-420a-b808-622781069950

Thesis Calcium phosphate transfection generates mammalian recombinant cell lines with higher specific productivity than polyfection

Chenuet, S; Martinet, D; Besuchet-Schmutz, N et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Calcium phosphate transfection generates mammalian recombinant cell lines with higher specific productivity than polyfection

Authors: Chenuet, S; Martinet, D; Besuchet-Schmutz, N; Wicht, M; Jaccard, N; Bon, AC; Derouazi, M; Hacker, DL; Beckmann, JS; Wurm, FM

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41402

Thesis Hepatocyte transfection in small pigs after weaning by hydrodynamic intraportal injection of naked DNA/minicircle vectors

Stoller, Fabienne; Schlegel, Andrea; Viecelli, Hiu Man et al. · 2015 · Vetsuisse Faculty Bern and Zurich · DOI

Full title: Hepatocyte transfection in small pigs after weaning by hydrodynamic intraportal injection of naked DNA/minicircle vectors

Authors: Stoller, Fabienne; Schlegel, Andrea; Viecelli, Hiu Man; Rüfenacht, Véronique; Cesarovic, Nikola; https://orcid.org/0000-0001-6744-2928; Viecelli, Claudio; Deplazes, Sereina; Bettschart, Regula; https://orcid.org/0000-0001-6259-9678; Hurter, Karin; Schmierer, Philipp; Sidler, Xaver; Kron, Philipp; https://orcid.org/0000-0002-6074-7072; Dutkowski, Philipp; Graf, Rolf; Thöny, Beat; https://orcid.org/0000-0002-8420-4769; Häberle, Johannes; https://orcid.org/0000-0003-0635-091X

Year: 2015

Venue: Vetsuisse Faculty Bern and Zurich

DOI: oai:www.zora.uzh.ch:20.500.14742/111722

Thesis Next-Generation Percutaneous Catheter–Based Closed-Loop Perfusion Concept Enables High-Precision Organ Delivery of Advanced Therapies

Emmert , Maximilian Y.; Holzmeister , Johannes; Blank , Ole et al. · 2025 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Next-Generation Percutaneous Catheter–Based Closed-Loop Perfusion Concept Enables High-Precision Organ Delivery of Advanced Therapies

Authors: Emmert , Maximilian Y.; Holzmeister , Johannes; Blank , Ole; Meyborg , Heike; Jomard , Anne; Mearini , Giulia; Vono , Maria; Weisskopf, Miriam; Michalski , Marco; Nagaraju , Chandan Kadur; Dehdashtian , Mark; Hollamby , Dominic; Rusconi , Chris; Zelenkofske , Steven; Falk, Volkmar; id_orcid0000-0002-7911-8620; Ayuso , Eduard; El Andari , Josef; Cesarovic , Nikola

Year: 2025

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/788000

Thesis Ex Vivo/In vivo Gene Editing in Hepatocytes Using “All-in-One” CRISPR-Adeno-Associated Virus Vectors with a Self-Linearizing Repair Template

Krooss, Simon Alexander; Dai, Zhen; Schmidt, Florian et al. · 2020 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Ex Vivo/In vivo Gene Editing in Hepatocytes Using “All-in-One” CRISPR-Adeno-Associated Virus Vectors with a Self-Linearizing Repair Template

Authors: Krooss, Simon Alexander; Dai, Zhen; Schmidt, Florian; Rovai, Alice; Fakhiri, Julia; Dhingra, Akshay; Yuan, Qinggong; Yang, Taihua; Balakrishnan, Asha; Steinbrück, Lars; Srivaratharajan, Sangar; Manns, Michael Peter; Schambach, Axel; Grimm, Dirk; Bohne, Jens; Sharma, Amar Deep; Büning, Hildegard; Ott, Michael

Year: 2020

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/401187

Thesis 25 years of recombinant proteins from reactor-grown cells — Where do we go from here?

Hacker, David L.; De Jesus, Maria; Wurm, Florian M. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: 25 years of recombinant proteins from reactor-grown cells — Where do we go from here?

Authors: Hacker, David L.; De Jesus, Maria; Wurm, Florian M.

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41353

Thesis Evaluation of Adeno-Associated Viral Vectors for Liver-Directed Gene Transfer in Dogs

Bell, Peter; Haskins, Mark E; Gao, Guangping et al. · 2023 · University of Pennsylvania · DOI

Full title: Evaluation of Adeno-Associated Viral Vectors for Liver-Directed Gene Transfer in Dogs

Authors: Bell, Peter; Haskins, Mark E; Gao, Guangping; Sleeper, Margaret M; Wang, Lili; Wang, Huan; Calcedo, Roberto; Vandenberghe, Luk H; Chen, Shu-Jen; Weisse, Chick; Withnall, Elanor; Wilson, James M

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/48978

Thesis Transfection using plasmid preparations

Wright, Jason; Wurm, Florian · 2015 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transfection using plasmid preparations

Authors: Wright, Jason; Wurm, Florian

Year: 2015

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/118469

Thesis Minicircle DNA-mediated endothelial nitric oxide synthase gene transfer enhances angiogenic responses of bone marrow-derived mesenchymal stem cells

Bandara, Nadeeka; Gurusinghe, Saliya; id_orcid 0000-0001-5779-3468 et al. · 2016 · Charles Sturt University - Research Output · DOI

Full title: Minicircle DNA-mediated endothelial nitric oxide synthase gene transfer enhances angiogenic responses of bone marrow-derived mesenchymal stem cells

Authors: Bandara, Nadeeka; Gurusinghe, Saliya; id_orcid 0000-0001-5779-3468; Chen, Haiying; Chen, Shuangfeng; Wang, Le-xin; Lim, Shiang Y.; Strappe, Padraig

Year: 2016

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/2145c668-9a85-476f-ad9f-0ad11c4bcb60

Thesis An Investigation into Factors affecting Ultrasound and Microbubble mediated Gene Transfection

Browning, Richard Johannes · 2012 · Imperial College London · DOI

Full title: An Investigation into Factors affecting Ultrasound and Microbubble mediated Gene Transfection

Authors: Browning, Richard Johannes

Year: 2012

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/9815

Thesis Design of a Novel Gene Therapy Construct to Achieve Sustained Brain-Derived Neurotrophic Factor Signaling in Neurons

Osborne, A; Wang, AXZ; Tassoni, A et al. · 2020 · University of Melbourne · DOI

Full title: Design of a Novel Gene Therapy Construct to Achieve Sustained Brain-Derived Neurotrophic Factor Signaling in Neurons

Authors: Osborne, A; Wang, AXZ; Tassoni, A; Widdowson, PS; Martin, KR

Year: 2020

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/250906

Thesis Polymeric Nanoparticles of Chitosan Derivatives as DNA and siRNA Carriers

Kim, Y. K.; Jiang, H. L.; Choi, Y. J. et al. · 2021 · Seoul National University · DOI

Full title: Polymeric Nanoparticles of Chitosan Derivatives as DNA and siRNA Carriers

Authors: Kim, Y. K.; Jiang, H. L.; Choi, Y. J.; Park, I. K.; Cho, M. H.; Cho, C. S.

Year: 2021

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/172291

Thesis A simple plasmid-based transient gene expression method using High Five cells

Shen, Xiao; Pitol, Ana K.; Bachmann, Virginie et al. · 2016 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A simple plasmid-based transient gene expression method using High Five cells

Authors: Shen, Xiao; Pitol, Ana K.; Bachmann, Virginie; Hacker, David L.; Baldi, Lucia; Wurm, Florian M.

Year: 2016

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/123880

Thesis High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells

Hildinger, Markus; Baldi, Lucia; Stettler, Matthieu et al. · 2007 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells

Authors: Hildinger, Markus; Baldi, Lucia; Stettler, Matthieu; Wurm, Florian M.

Year: 2007

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/66202

Thesis Transferinfection - a Highly Efficient Way to Express Gene Constructs in Eukaryotic Cells

Zatloukal, K.; Wagner, E.; Cotten, M. et al. · 1992 · Technical University of Munich (TUM) · DOI

Full title: Transferinfection - a Highly Efficient Way to Express Gene Constructs in Eukaryotic Cells

Authors: Zatloukal, K. ; Wagner, E. ; Cotten, M. ; Phillips, S. ; Plank, C. ; Steinlein, P. ; Curiel, D. T. ; Birnstiel, M. L.

Year: 1992

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/805553

Thesis Cellular transfection of small interfering ribonucleic acids. Electroporation as an alternative to liposome-based delivery transfection methods

Jacot, Guillaume · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Cellular transfection of small interfering ribonucleic acids. Electroporation as an alternative to liposome-based delivery transfection methods

Authors: Jacot, Guillaume

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/57785

Thesis Investigating the Differential Regulation of Cell Surface GAG in Cancer: Using NGPD to Isolate Cancer Cell Specific Peptides

Hardie, Derek T. · 2024 · University of Nottingham · DOI

Full title: Investigating the Differential Regulation of Cell Surface GAG in Cancer: Using NGPD to Isolate Cancer Cell Specific Peptides

Authors: Hardie, Derek T.

Year: 2024

Venue: University of Nottingham

DOI: https://eprints.nottingham.ac.uk/77413/1/Hardie%20Derek%2014342060%20corrections.pdf

Thesis Optimization of artificial neural network by genetic algorithm for describing viral production from uniform design data

Takahashi, Maria Beatriz [UNESP]; Rocha, Jose Celso [UNESP]; Fernandez Nunez, Eutimio Gustavo [UNESP] · 2018 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Optimization of artificial neural network by genetic algorithm for describing viral production from uniform design data

Authors: Takahashi, Maria Beatriz [UNESP]; Rocha, Jose Celso [UNESP]; Fernandez Nunez, Eutimio Gustavo [UNESP]

Year: 2018

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1016/j.procbio.2015.12.005

Thesis Gene transfer into rat mesenchymal stem cells:A comparative study of viral and nonviral vectors

McMahon, J.M.; Conroy, S; Lyons, M et al. · 2006 · Charles Sturt University - Research Output · DOI

Full title: Gene transfer into rat mesenchymal stem cells:A comparative study of viral and nonviral vectors

Authors: McMahon, J.M.; Conroy, S; Lyons, M; Greiser, U; O'Shea, C; Strappe, P; Howard, L; Murphy, M; Barry, F; O'Brien, T

Year: 2006

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/038095fe-fe5d-4031-8977-e555dc3fb424

Thesis High Gene Transfer by the Osmotic Polysorbitol-Mediated Transporter through the Selective Caveolae Endocytic Pathway

Quynh-Phuong Luu; Shin, Ji-Young; Kim, You-Kyoung et al. · 2021 · Seoul National University · DOI

Full title: High Gene Transfer by the Osmotic Polysorbitol-Mediated Transporter through the Selective Caveolae Endocytic Pathway

Authors: Quynh-Phuong Luu; Shin, Ji-Young; Kim, You-Kyoung; Islam, Mohammad Ariful; Kang, Sang-Kee; Cho, Myung-Haing; Choi, Yun-Jaie; Cho, Chong-Su

Year: 2021

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/172474

Thesis Adeno-associated vector-delivered CRISPR/SaCas9 system reduces Feline Leukemia Virus production in vitro

Helfer-Hungerbuehler, A Katrin; https://orcid.org/0000-0001-6954-1815; Shah, Jimit et al. · 2021 · Vetsuisse Faculty Bern and Zurich · DOI

Full title: Adeno-associated vector-delivered CRISPR/SaCas9 system reduces Feline Leukemia Virus production in vitro

Authors: Helfer-Hungerbuehler, A Katrin; https://orcid.org/0000-0001-6954-1815; Shah, Jimit; Meili, Theres; Boenzli, Eva; Li, Pengfei; Hofmann-Lehmann, Regina; https://orcid.org/0000-0001-9750-4296

Year: 2021

Venue: Vetsuisse Faculty Bern and Zurich

DOI: oai:www.zora.uzh.ch:20.500.14742/185882

Thesis Epizone: Interlaboratory Ring Trial to Compare Dna Transfection Efficiencies

Dory, Daniel; Albina, Emmanuel; Kwiatek, Olivier et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: Epizone: Interlaboratory Ring Trial to Compare Dna Transfection Efficiencies

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/13cec1b4-21dc-400d-8868-fdb9a9a75c2e

Thesis The use of filler DNA for improved transfection and reduced DNA needs in transient gene expression with CHO and HEK cells

Kiseljak, Divor; Rajendra, Yashas; Manoli, Sagar S. et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: The use of filler DNA for improved transfection and reduced DNA needs in transient gene expression with CHO and HEK cells

Authors: Kiseljak, Divor; Rajendra, Yashas; Manoli, Sagar S.; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76413

Thesis Glycan variability on a recombinant IgG antibody transiently produced in HEK-293E cells

Nallet, Sophie; Fornelli, Luca; Schmitt, Simone et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Glycan variability on a recombinant IgG antibody transiently produced in HEK-293E cells

Authors: Nallet, Sophie; Fornelli, Luca; Schmitt, Simone; Parra, Julien; Baldi, Lucia; Tsybin, Yury O.; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/79951

Thesis Recent advances in magnetofection and its potential to deliver siRNAs in vitro.

Mykhaylyk, O; Zelphati, O; Hammerschmid, E et al. · 2009 · Technical University of Munich (TUM) · DOI

Full title: Recent advances in magnetofection and its potential to deliver siRNAs in vitro.

Authors: Mykhaylyk, O;Zelphati, O;Hammerschmid, E;Anton, M;Rosenecker, J;Plank, C

Year: 2009

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/824242

Thesis Impact of chemically defined culture media formulations on extracellular vesicle production by amniotic epithelial cells

Zhu, Dandan; Fang, Haoyun; Kusuma, Gina D et al. · 2021 · Charles Sturt University - Research Output · DOI

Full title: Impact of chemically defined culture media formulations on extracellular vesicle production by amniotic epithelial cells

Authors: Zhu, Dandan; Fang, Haoyun; Kusuma, Gina D; Schwab, Renate; id_orcid 0000-0002-5551-1700; Barabadi, Mehri; Chan, Siow Teng; McDonald, Hannah; Leong, Cheng Mee; Wallace, Euan M; Greening, David W; Lim, Rebecca

Year: 2021

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/86052785-ab5c-49b1-8757-2089472b3a36

Thesis Establishing an in-house lentiviral vector platform and associated analytics

Toh, Xavier Yi Quan · 2025 · Nanyang Technological University (NTU) · DOI

Full title: Establishing an in-house lentiviral vector platform and associated analytics

Authors: Toh, Xavier Yi Quan

Year: 2025

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/184350

Thesis Streamlined, single-step non-viral CRISPR-Cas9 knockout strategy enhances gene editing efficiency in primary human chondrocyte populations

Ponta, Simone; Bonato, Angela; id_orcid0000-0001-5991-2483 et al. · 2024 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Streamlined, single-step non-viral CRISPR-Cas9 knockout strategy enhances gene editing efficiency in primary human chondrocyte populations

Authors: Ponta, Simone; Bonato, Angela; id_orcid0000-0001-5991-2483; Neidenbach, Philipp; Bruhin, Valentino F.; Laurent, Alexis; Applegate, Lee Ann; Zenobi-Wong, Marcy; id_orcid0000-0001-5991-2483; Barreto, Goncalo

Year: 2024

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/665564

Thesis Biodegradable poly(ester amine) based on glycerol dimethacrylate and polyethylenimine as a gene carrier

Arote, Rohidas B.; Hwang, Soon-Kyung; Yoo, Mi-Kyong et al. · 2021 · Seoul National University · DOI

Full title: Biodegradable poly(ester amine) based on glycerol dimethacrylate and polyethylenimine as a gene carrier

Authors: Arote, Rohidas B.; Hwang, Soon-Kyung; Yoo, Mi-Kyong; Jere, Dhananjay; Jiang, Hu-Lin; Kim, You-Kyoung; Choi, Yun-Jai; Nah, Jae-Woon; Cho, Myung-Haing; Cho, Chong-Su

Year: 2021

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/172428

Thesis Optimization of Recombinant Protein Production in Different Cell Lines

Ouyang, Chu · 2024 · Johns Hopkins University · DOI

Full title: Optimization of Recombinant Protein Production in Different Cell Lines

Authors: Ouyang, Chu

Year: 2024

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/69633

Thesis Gene transfer and protein dynamics in stem cells using single cell electroporation in a microfluidic device

Valero, A.; Post, J. N.; van Nieuwkasteele, J. W. et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Gene transfer and protein dynamics in stem cells using single cell electroporation in a microfluidic device

Authors: Valero, A.; Post, J. N.; van Nieuwkasteele, J. W.; ter Braak, P. M.; Kruijer, W.; van den Berg, A.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/61671

Thesis The efficiency of nuclear plasmid DNA delivery is a critical determinant of transgene expression at the single cell level

Glover, DJ; Leyton, DL; Moseley, GW et al. · 2015 · University of Melbourne · DOI

Full title: The efficiency of nuclear plasmid DNA delivery is a critical determinant of transgene expression at the single cell level

Authors: Glover, DJ; Leyton, DL; Moseley, GW; Jans, DA

Year: 2015

Venue: University of Melbourne

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000273895600008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c

Thesis Technical challenges in the development of reverse genetics for a viral haemorrhagic septicaemia virus (VHSV) genotype Ib isolate: Alternative cell lines and general troubleshooting

Farias Alencar, Anna Luiza; id_orcid 0000-0002-4864-9111; Cuenca, Argelia et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Technical challenges in the development of reverse genetics for a viral haemorrhagic septicaemia virus (VHSV) genotype Ib isolate: Alternative cell lines and general troubleshooting

Authors: Farias Alencar, Anna Luiza; id_orcid 0000-0002-4864-9111; Cuenca, Argelia; id_orcid 0000-0001-8596-1086; Olesen, Niels Jørgen; id_orcid 0000-0002-0152-4135; Rasmussen, Thomas Bruun

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/6a3771ad-d0db-459b-820a-828e706376b5

Thesis Combinatorial treatment with lithium chloride enhances recombinant antibody production in transiently transfected CHO and HEK293E cells

Kim, Che Lin; Kwang Ha, Tae; Min Lee, Gyun · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Combinatorial treatment with lithium chloride enhances recombinant antibody production in transiently transfected CHO and HEK293E cells

Authors: Kim, Che Lin; Kwang Ha, Tae; Min Lee, Gyun

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/01b5ec11-ab2c-410e-8ab0-629bf31319da

Thesis Optimal delivery of therapeutic genes to pancreatic islets.

Hughes, Amy · 2013 · University of Adelaide · DOI

Full title: Optimal delivery of therapeutic genes to pancreatic islets.

Authors: Hughes, Amy

Year: 2013

Venue: University of Adelaide

DOI: http://hdl.handle.net/2440/81571

Thesis Characterization of key manufacturing uncertainties in next generation therapeutics and vaccines across scales

Sarkis, Miriam; Shah, Nilay; Papathanasiou, Maria M · 2024 · Imperial College London · DOI

Full title: Characterization of key manufacturing uncertainties in next generation therapeutics and vaccines across scales

Authors: Sarkis, Miriam; Shah, Nilay; Papathanasiou, Maria M

Year: 2024

Venue: Imperial College London

DOI: http://dx.doi.org/10.1002/amp2.10158

Thesis Transient Gene Expression in HEK-293E Cells for Recombinant Protein Production : Process Characterization towards GMP Approval

Nallet, Sophie · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transient Gene Expression in HEK-293E Cells for Recombinant Protein Production : Process Characterization towards GMP Approval

Authors: Nallet, Sophie

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/52010

Thesis GENE THERAPY FOR GYRATE ATROPHY OF CHOROID AND RETINA AND FOR USH1B RETINITIS PIGMENTOSA

DELL'AQUILA, FABIO · 2021 · Università degli Studi di Milano (AIR) · DOI

Full title: GENE THERAPY FOR GYRATE ATROPHY OF CHOROID AND RETINA AND FOR USH1B RETINITIS PIGMENTOSA

Authors: DELL'AQUILA, FABIO

Year: 2021

Venue: Università degli Studi di Milano (AIR)

DOI: http://hdl.handle.net/2434/884458

Thesis STRUCTURAL IMPLICATIONS OF GLUCOSE AND COPPER AVAILABILITY ON GLYCATION PROCESSES IN CHINESE HAMSTER OVARIAN (CHO) CELL-DERIVED PROTEINS

Vasamsetti, Sree Lakshmi Harita · 2025 · Johns Hopkins University · DOI

Full title: STRUCTURAL IMPLICATIONS OF GLUCOSE AND COPPER AVAILABILITY ON GLYCATION PROCESSES IN CHINESE HAMSTER OVARIAN (CHO) CELL-DERIVED PROTEINS

Authors: Vasamsetti, Sree Lakshmi Harita

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70784

Thesis Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing

Williams, Thomas; Sanches, Rui; Blanchard-Emmerson, Greg et al. · 2023 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing

Authors: Williams, Thomas; Sanches, Rui; Blanchard-Emmerson, Greg; Watts, Samuel; Davies, Lee; Knevelman, Carol; McCloskey, Laura; Jones, Peter; Mitrophanous, Kyriacos; Miskin, James; Dikicioglu, Duygu

Year: 2023

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/596703

Thesis POLY(BETA-AMINO ESTER)-POLYETHYLENIMINE-BASED NANOPARTICLE TRANSFECTION FOR ADENO-ASSOCIATED VIRUS PRODUCTION

Alla, Sri Sai Vivek · 2023 · Johns Hopkins University · DOI

Full title: POLY(BETA-AMINO ESTER)-POLYETHYLENIMINE-BASED NANOPARTICLE TRANSFECTION FOR ADENO-ASSOCIATED VIRUS PRODUCTION

Authors: Alla, Sri Sai Vivek

Year: 2023

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/68568

Thesis Junk DNA enhances pEI-based non-viral gene delivery

Gaal, E.V.B. van; Oosting, R.S.; Hennink, W.E. et al. · 2010 · Utrecht University · DOI

Full title: Junk DNA enhances pEI-based non-viral gene delivery

Authors: Gaal, E.V.B. van; Oosting, R.S.; Hennink, W.E.; Crommelin, D.J.A.; Mastrobattista, E.

Year: 2010

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/44852

Thesis Hyperbranched Polylysine: A Versatile, Biodegradable Transfection Agent for the Production of Recombinant Proteins by Transient Gene Expression and the Transfection of Primary Cells

Kadlecova, Zuzana; Rajendra, Yashas; Matasci, Mattia et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Hyperbranched Polylysine: A Versatile, Biodegradable Transfection Agent for the Production of Recombinant Proteins by Transient Gene Expression and the Transfection of Primary Cells

Authors: Kadlecova, Zuzana; Rajendra, Yashas; Matasci, Mattia; Hacker, David; Baldi, Lucia; Wurm, Florian Maria; Klok, Harm-Anton

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/82461

Thesis Comparative evaluation of viral, nonviral and physical methods of gene delivery to normal and transformed lung epithelial cells

Gilbert, Jennifer L.; Purcell, James; Strappe, Padraig et al. · 2008 · Charles Sturt University - Research Output · DOI

Full title: Comparative evaluation of viral, nonviral and physical methods of gene delivery to normal and transformed lung epithelial cells

Authors: Gilbert, Jennifer L.; Purcell, James; Strappe, Padraig; McCabe, Matthew; OBrien, Timothy; ODea, Shirley

Year: 2008

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/bbce1bd8-03fe-45db-931f-17a027168735

Thesis Magnetic and acoustically active microbubbles loaded with nucleic acids for gene delivery.

Vlaskou, Dialechti; Plank, Christian; Mykhaylyk, Olga · 2013 · Technical University of Munich (TUM) · DOI

Full title: Magnetic and acoustically active microbubbles loaded with nucleic acids for gene delivery.

Authors: Vlaskou, Dialechti;Plank, Christian;Mykhaylyk, Olga

Year: 2013

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1210936

Thesis A biodegradable poly(ester amine) based on polycaprolactone and polyethylenimine as a gene carrier

Arote, Rohidas; Kim, Tae-Hee; Kim, You-Kyoung et al. · 2021 · Seoul National University · DOI

Full title: A biodegradable poly(ester amine) based on polycaprolactone and polyethylenimine as a gene carrier

Authors: Arote, Rohidas; Kim, Tae-Hee; Kim, You-Kyoung; Hwang, Soon-Kyung; Jiang, Hu-Lin; Song, Ho-Hyun; Nah, Jae-Woon; Cho, Myung-Haing; Cho, Chong-Su

Year: 2021

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/172337

Thesis Caractérisation et optimisation de la production d’adénovirus dans les cellules 293SF en mode perfusion

Dormond, Edwige · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Caractérisation et optimisation de la production d’adénovirus dans les cellules 293SF en mode perfusion

Authors: Dormond, Edwige

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/8587

Thesis Generation of stable, high-producing cho cell lines by lentiviral vector-mediated gene transfer in serum-free suspension culture

Oberbek, Agata; Matasci, Mattia; Hacker, David L. et al. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Generation of stable, high-producing cho cell lines by lentiviral vector-mediated gene transfer in serum-free suspension culture

Authors: Oberbek, Agata; Matasci, Mattia; Hacker, David L.; Wurm, Florian M.

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/64220

Thesis Transient Gene Expression in Mammalian Cells: Promises and Challenges for Medical Biotechnology

Hacker, David L.; Baldi, Lucia; Adam, Myriam et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transient Gene Expression in Mammalian Cells: Promises and Challenges for Medical Biotechnology

Authors: Hacker, David L.; Baldi, Lucia; Adam, Myriam; Wurm, Florian M.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/50531

Thesis Analysis of charged polymer effects on recombinant retrovirus-mediated gene transfer success

Davis, Howard E. (Howard Elliot), 1973- · 2005 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Analysis of charged polymer effects on recombinant retrovirus-mediated gene transfer success

Authors: Davis, Howard E. (Howard Elliot), 1973-

Year: 2005

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/8350

Thesis Etablierung der Isolierung, selektiven Anreicherung und Transfektion adulter Schwann-Zellen der Ratte und des Menschen zur Überexpression von FGF-2-Isoformen

Mauritz, Christina · 2005 · University of Veterinary Medicine Hannover (TiHo) · DOI

Full title: Etablierung der Isolierung, selektiven Anreicherung und Transfektion adulter Schwann-Zellen der Ratte und des Menschen zur Überexpression von FGF-2-Isoformen

Authors: Mauritz, Christina

Year: 2005

Venue: University of Veterinary Medicine Hannover (TiHo)

DOI: https://nbn-resolving.org/urn:nbn:de:gbv:95-90575

Thesis Optimizing hyaluronidase dose and plasmid DNA delivery greatly improves gene electrotransfer efficiency in rat skeletal muscle

Åkerström, Thorbjörn; Vedel, Kenneth; Needham Andersen, Josefine et al. · 2015 · University of Copenhagen · DOI

Full title: Optimizing hyaluronidase dose and plasmid DNA delivery greatly improves gene electrotransfer efficiency in rat skeletal muscle

Authors: Åkerström, Thorbjörn; Vedel, Kenneth; Needham Andersen, Josefine; Hojman, Pernille; Kontou, Eftychia; Hellsten, Ylva; Wojtaszewski, Jørgen

Year: 2015

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/f0d31302-4e31-48c0-88e9-a1143b122486

Thesis Transient gene expression: recombinant protein production with suspension-adapted HEK293-EBNA cells

Meissner, P.; Pick, H.; Kulangara, A. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transient gene expression: recombinant protein production with suspension-adapted HEK293-EBNA cells

Authors: Meissner, P.; Pick, H.; Kulangara, A.; Chatellard, P.; Friedrich, K.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7617

Thesis Gene Delivery with Hyperbranched Polylysine

Kadlecova, Zuzana · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Gene Delivery with Hyperbranched Polylysine

Authors: Kadlecova, Zuzana

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/71146

Thesis Tuning Post-Translational Modifications in Mammalian Cells: Exploring Media Optimization and Gene Editing Strategies

Aliyu, Lateef · 2025 · Johns Hopkins University · DOI

Full title: Tuning Post-Translational Modifications in Mammalian Cells: Exploring Media Optimization and Gene Editing Strategies

Authors: Aliyu, Lateef

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70660

Thesis Efficient Gene Delivery with Osmotically Active and Hyperbranched Poly(ester amine)s

Arote, Rohidas B.; Lee, Eun-Sun; Jiang, Hu-Lin et al. · 2021 · Seoul National University · DOI

Full title: Efficient Gene Delivery with Osmotically Active and Hyperbranched Poly(ester amine)s

Authors: Arote, Rohidas B.; Lee, Eun-Sun; Jiang, Hu-Lin; Kim, You-Kyoung; Choi, Yun-Jaie; Cho, Myung-Haing; Cho, Chong-Su

Year: 2021

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/172328

Thesis HIGH-THROUGHPUT APPROACHES TO PROTEIN ENGINEERING APPLIED TO THE CAS9 AND AAV2 REP GENES

Spisak, Shaun Thomas · 2025 · Johns Hopkins University · DOI

Full title: HIGH-THROUGHPUT APPROACHES TO PROTEIN ENGINEERING APPLIED TO THE CAS9 AND AAV2 REP GENES

Authors: Spisak, Shaun Thomas

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70232

Thesis Transfer of high copy number plasmid into mammalian cells by calcium phosphate transfection

Batard, P.; Jordan, M.; Wurm, F. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transfer of high copy number plasmid into mammalian cells by calcium phosphate transfection

Authors: Batard, P.; Jordan, M.; Wurm, F.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7589

Thesis Living myocardial slices for the study of nucleic acid-based therapies

Nunez-Toldra, Raquel; Del Canizo, A; Secco, I et al. · 2023 · Imperial College London · DOI

Full title: Living myocardial slices for the study of nucleic acid-based therapies

Authors: Nunez-Toldra, Raquel; Del Canizo, A; Secco, I; Nicastro, L; Giacca, M; Terracciano, Cesare

Year: 2023

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/107432

Thesis A fibrin glue composition as carrier for nucleic acid vectors.

Schillinger, U; Wexel, G; Hacker, C et al. · 2008 · Technical University of Munich (TUM) · DOI

Full title: A fibrin glue composition as carrier for nucleic acid vectors.

Authors: Schillinger, U;Wexel, G;Hacker, C;Kullmer, M;Koch, C;Gerg, M;Vogt, S;Ueblacker, P;Tischer, T;Hensler, D;Wilisch, J;Aigner, J;Walch, A;Stemberger, A;Plank, C

Year: 2008

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/693762

Thesis Balancing GFP reporter plasmid quantity in large-scale transient transfections for recombinant anti-human Rhesus-D IgG1 synthesis

Pick, H. M.; Meissner, P.; Preuss, A. K. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Balancing GFP reporter plasmid quantity in large-scale transient transfections for recombinant anti-human Rhesus-D IgG1 synthesis

Authors: Pick, H. M.; Meissner, P.; Preuss, A. K.; Tromba, P.; Vogel, H.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7630

Thesis Engineering whole-body gene therapies for aging

Florea, Michael · 2023 · Harvard University - DASH · DOI

Full title: Engineering whole-body gene therapies for aging

Authors: Florea, Michael

Year: 2023

Venue: Harvard University - DASH

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37375576

Thesis Enhanced Cellular Uptake through Nanotopography-Induced Macropinocytosis

Aramesh, Morteza; id_orcid0000-0003-2071-1929; Yu, Di et al. · 2024 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Enhanced Cellular Uptake through Nanotopography-Induced Macropinocytosis

Authors: Aramesh, Morteza; id_orcid0000-0003-2071-1929; Yu, Di; Essand, Magnus; Persson, Cecilia

Year: 2024

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/665382

Thesis Targeted knockdown of ATM, ATR, and PDEδ increases Gag HIV-1 VLP production in HEK293 cells

Díaz-Maneh, Andy; Pérez-Rubio, Pol; Granes, Cristina Rigau et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Targeted knockdown of ATM, ATR, and PDEδ increases Gag HIV-1 VLP production in HEK293 cells

Authors: Díaz-Maneh, Andy; Pérez-Rubio, Pol; Granes, Cristina Rigau; Bosch-Molist, Laia; Lavado-García, Jesús; Gòdia, Francesc; Cervera, Laura

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/45e24517-ea8b-44f2-a6c2-ae6c443775a8

Thesis A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

Lund, Anne Mathilde; Kildegaard, Helene Faustrup; Petersen, Maja Borup Kjær et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1e6b9cdd-536a-420a-b808-622781069950

Thesis Delivery of a lentiviral vector in a Pluronic F127 gel to cells of the central nervous system

Strappe, Padraig M.; Hampton, David W.; Cachon-Gonzalez, Begona et al. · 2005 · Charles Sturt University - Research Output · DOI

Full title: Delivery of a lentiviral vector in a Pluronic F127 gel to cells of the central nervous system

Authors: Strappe, Padraig M.; Hampton, David W.; Cachon-Gonzalez, Begona; Fawcett, James W.; Lever, Andrew

Year: 2005

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/47fce20e-a1b4-4773-b2da-49fa6d4dc0b0

Thesis Comparison between direct and reverse electroporation of cells in situ: a simulation study

Krams, R; Towhidi, L; Khodadadi, D et al. · 2016 · Imperial College London · DOI

Full title: Comparison between direct and reverse electroporation of cells in situ: a simulation study

Authors: Krams, R; Towhidi, L; Khodadadi, D; Maimari, N; Pedrigi, R; Ip, H; Kis, Z; Kwak, B; Petrova, T; Delorenzi, M

Year: 2016

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/29941

Thesis Nucleic acid based therapeutic approaches

Joacim Elmén (6729) · 2005 · Karolinska Institutet · DOI

Full title: Nucleic acid based therapeutic approaches

Authors: Joacim Elmén (6729)

Year: 2005

Venue: Karolinska Institutet

DOI: oai:figshare.com:article/26898139

Thesis Large-Scale Transfection of Mammalian Cells

Baldi, Lucia; Hacker, David L.; Meerschman, Carine et al. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Large-Scale Transfection of Mammalian Cells

Authors: Baldi, Lucia; Hacker, David L.; Meerschman, Carine; Wurm, Florian M.

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/71799

Thesis Navigating biomanufacturing challenges in the use of CHO cells for recombinant adeno-associated virus production

Tatjer, David Catalán; id_orcid 0000-0002-0900-9912 · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Navigating biomanufacturing challenges in the use of CHO cells for recombinant adeno-associated virus production

Authors: Tatjer, David Catalán; id_orcid 0000-0002-0900-9912

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9209d5ce-66e5-452d-9d20-a94da77a0102

Thesis The development of HIV-1 derived gene transfer technology: optimisation of vector safety, processing and production.

Koldej, Rachel Marie · 2008 · University of Adelaide · DOI

Full title: The development of HIV-1 derived gene transfer technology: optimisation of vector safety, processing and production.

Authors: Koldej, Rachel Marie

Year: 2008

Venue: University of Adelaide

DOI: http://hdl.handle.net/2440/42907

Thesis A novel transfecting peptide comprising a tetrameric nuclear localization sequence.

Ritter, W; Plank, C; Lausier, J et al. · 2003 · Technical University of Munich (TUM) · DOI

Full title: A novel transfecting peptide comprising a tetrameric nuclear localization sequence.

Authors: Ritter, W;Plank, C;Lausier, J;Rudolph, C;Zink, D;Reinhardt, D;Rosenecker, J

Year: 2003

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1330224

Thesis Nanomagnetic activation as a way to control the efficacy of nucleic acid delivery.

Grze?kowiak, Bartosz F; Sanchez-Antequera, Yolanda; Hammerschmid, Edelburga et al. · 2015 · Technical University of Munich (TUM) · DOI

Full title: Nanomagnetic activation as a way to control the efficacy of nucleic acid delivery.

Authors: Grze?kowiak, Bartosz F;Sanchez-Antequera, Yolanda;Hammerschmid, Edelburga;Döblinger, Markus;Eberbeck, Dietmar;Wo?niak, Anna;S?omski, Ryszard;Plank, Christian;Mykhaylyk, Olga

Year: 2015

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1321595

Thesis Cell and Gene Therapy Strategies for Treatment of Bone Fragility Disorders

Lee, Lucinda · 2020 · University of Sydney · DOI

Full title: Cell and Gene Therapy Strategies for Treatment of Bone Fragility Disorders

Authors: Lee, Lucinda

Year: 2020

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/22007

Thesis Novel orbital shake bioreactors for transient production of CHO derived IgGs

Stettler, Matthieu; Zhang, Xiaowei; Hacker, David L. et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Novel orbital shake bioreactors for transient production of CHO derived IgGs

Authors: Stettler, Matthieu; Zhang, Xiaowei; Hacker, David L.; De Jesus, Maria; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/83449

Thesis Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium.

Rudolph, C; Schillinger, U; Ortiz, A et al. · 2005 · Technical University of Munich (TUM) · DOI

Full title: Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium.

Authors: Rudolph, C;Schillinger, U;Ortiz, A;Plank, C;Golas, MM;Sander, B;Stark, H;Rosenecker, J

Year: 2005

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1330338

Thesis The Use of Valproic Acid in Transient Gene Expression with HEK-293E Cells

Kiseljak, Divor · 2013 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: The Use of Valproic Acid in Transient Gene Expression with HEK-293E Cells

Authors: Kiseljak, Divor

Year: 2013

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/87934

Thesis The use of RNA interference to increase PEI-mediated transient gene expression in mammalian cells

Bertschinger, Martin · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: The use of RNA interference to increase PEI-mediated transient gene expression in mammalian cells

Authors: Bertschinger, Martin

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/221656

Thesis Production of recombinant protein therapeutics in cultivated mammalian cells

Wurm, F. M. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Production of recombinant protein therapeutics in cultivated mammalian cells

Authors: Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7667

Thesis Enhanced Plasmid DNA Utilization in Transiently Transfected CHO-DG44 Cells in the Presence of Polar Solvents

Rajendra, Yashas; Balasubramanian, Sowmya; Kiseljak, Divor et al. · 2016 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Enhanced Plasmid DNA Utilization in Transiently Transfected CHO-DG44 Cells in the Presence of Polar Solvents

Authors: Rajendra, Yashas; Balasubramanian, Sowmya; Kiseljak, Divor; Baldi, Lucia; Wurm, Florian M.; Hacker, David L.

Year: 2016

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/124119

Thesis Highly efficient lentiviral vector-mediated transduction of nondividing, fully reimplantable primary hepatocytes

Nguyen, Tuan Huy; Oberholzer, José; Birraux, Jacques et al. · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Highly efficient lentiviral vector-mediated transduction of nondividing, fully reimplantable primary hepatocytes

Authors: Nguyen, Tuan Huy; Oberholzer, José; Birraux, Jacques; Majno, Pietro; Morel, Philippe; Trono, Didier

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/215880

Thesis Targeted knockdown of ATM, ATR, and PDEδ increases Gag HIV-1 VLP production in HEK293 cells

Díaz-Maneh, Andy; Pérez-Rubio, Pol; Granes, Cristina Rigau et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Targeted knockdown of ATM, ATR, and PDEδ increases Gag HIV-1 VLP production in HEK293 cells

Authors: Díaz-Maneh, Andy; Pérez-Rubio, Pol; Granes, Cristina Rigau; Bosch-Molist, Laia; Lavado-García, Jesús; Gòdia, Francesc; Cervera, Laura

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/45e24517-ea8b-44f2-a6c2-ae6c443775a8

Thesis Transfection of partially purified plasmid DNA for high level transient protein expression in HEK293-EBNA cells

Wright, J. L.; Jordan, M.; Wurm, F. M. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transfection of partially purified plasmid DNA for high level transient protein expression in HEK293-EBNA cells

Authors: Wright, J. L.; Jordan, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7657

Thesis Isolation and evaluation of novel adeno-associated virus sequences from porcine tissues

Bello, A.; Tran, K.; Chand, A. et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Isolation and evaluation of novel adeno-associated virus sequences from porcine tissues

Authors: Bello, A.; Tran, K.; Chand, A.; Doria, M.; Allocca, M.; Hildinger, M.; Beniac, D.; Kranendonk, C.; Auricchio, A.; Kobinger, G. P.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/56639

Thesis Influence of glutamine on transient and stable recombinant protein production in CHO and HEK-293 cells

Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Influence of glutamine on transient and stable recombinant protein production in CHO and HEK-293 cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76415

Thesis Integration pattern of HIV-1 based lentiviral vector carrying recombinant coagulation factor VIII in Sk-Hep and 293T cells

Covas, Dimas Tadeu · 2011 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Integration pattern of HIV-1 based lentiviral vector carrying recombinant coagulation factor VIII in Sk-Hep and 293T cells

Authors: Covas, Dimas Tadeu

Year: 2011

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.1007/s10529-010-0387-5

Thesis Development of AAV-mediated gene therapy for autosomal recessive bestrophinopathy

Wood, S · 2017 · University of Oxford - ORA · DOI

Full title: Development of AAV-mediated gene therapy for autosomal recessive bestrophinopathy

Authors: Wood, S

Year: 2017

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:e0925bc0-8f36-4a76-9366-bc7dc316c5af

Thesis Measurable parameters of cells and precipitate predict transfectability with calcium phosphate

Jordan, M.; Wurm, F. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Measurable parameters of cells and precipitate predict transfectability with calcium phosphate

Authors: Jordan, M.; Wurm, F.

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/70789

Thesis Bacteriophage mediates efficient gene transfer in combination with conventional transfection reagents

Donnelly, A; Yata, T; Bentayebi, K et al. · 2015 · Imperial College London · DOI

Full title: Bacteriophage mediates efficient gene transfer in combination with conventional transfection reagents

Authors: Donnelly, A; Yata, T; Bentayebi, K; Suwan, K; Hajitou, A

Year: 2015

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/28249

Thesis One size does not fit all: The effect of chain length and charge density of poly(ethylene imine) based copolymers on delivery of pDNA, mRNA, and repRNA polyplexes.

Blakney, Anna K; Yilmaz, Gokhan; McKay, Paul F et al. · 2018 · Imperial College London · DOI

Full title: One size does not fit all: The effect of chain length and charge density of poly(ethylene imine) based copolymers on delivery of pDNA, mRNA, and repRNA polyplexes.

Authors: Blakney, Anna K; Yilmaz, Gokhan; McKay, Paul F; Becer, C Remzi; Shattock, Robin J

Year: 2018

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/29698602

Thesis Poly (amino ester) composed of poly (ethylene glycol) and aminosilane prepared by combinatorial chemistry as a gene carrier

Jere, Dhananjay; Yoo, Mi-Kyong; Arote, Rohidas et al. · 2021 · Seoul National University · DOI

Full title: Poly (amino ester) composed of poly (ethylene glycol) and aminosilane prepared by combinatorial chemistry as a gene carrier

Authors: Jere, Dhananjay; Yoo, Mi-Kyong; Arote, Rohidas; Kim, Tae-Hee; Cho, Myung-Haing; Nah, Jae-Woon; Choi, Yun-Jaie; Cho, Chong-Su

Year: 2021

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/172496

Thesis Development of an intein-mediated split-Cas9 system for gene therapy.

Truong, Dong-Jiunn Jeffery; Kühner, Karin; Kühn, Ralf et al. · 2015 · Technical University of Munich (TUM) · DOI

Full title: Development of an intein-mediated split-Cas9 system for gene therapy.

Authors: Truong, Dong-Jiunn Jeffery;Kühner, Karin;Kühn, Ralf;Werfel, Stanislas;Engelhardt, Stefan;Wurst, Wolfgang;Ortiz, Oskar

Year: 2015

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1322926

Thesis Purification of adenovirus and adeno-associated virus:Comparison of novel membrane-based technology to conventional techniques

Duffy, A.M.; O'Doherty, A.M.; O'Brien, T. et al. · 2005 · Charles Sturt University - Research Output · DOI

Full title: Purification of adenovirus and adeno-associated virus:Comparison of novel membrane-based technology to conventional techniques

Authors: Duffy, A.M.; O'Doherty, A.M.; O'Brien, T.; Strappe, P.M.

Year: 2005

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/11730150-8234-4f79-8f8d-a76b331551fe

Thesis Expansion, differentiation and transfection of ventral mesencephalic progenitor cells

Cesnulevicius, Konstantin · 2006 · University of Veterinary Medicine Hannover (TiHo) · DOI

Full title: Expansion, differentiation and transfection of ventral mesencephalic progenitor cells

Authors: Cesnulevicius, Konstantin

Year: 2006

Venue: University of Veterinary Medicine Hannover (TiHo)

DOI: https://nbn-resolving.org/urn:nbn:de:gbv:95-93504

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2. Data Extraction

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Paper

Recombinant AAV Vectors for Enhanced Expression of Authentic IgG.

Fuchs, Sebastian P, Martinez-Navio, José M, Gao, Guangping, Desrosiers, Ronald C · 2016

Full title: Recombinant AAV Vectors for Enhanced Expression of Authentic IgG.

Authors: Fuchs, Sebastian P, Martinez-Navio, José M, Gao, Guangping, Desrosiers, Ronald C

DOI: https://doi.org/10.1371/journal.pone.0158009

Paper

Platforms, advances, and technical challenges in virus-like particles-based vaccines

Gupta, Reeshu, Arora, Kajal, Roy, Sourav Singha, Joseph, Abyson, Rastogi, Ruchir, Arora, Nupur Mehrotra, Kundu, Prabuddha K. · 2023

Full title: Platforms, advances, and technical challenges in virus-like particles-based vaccines

Authors: Gupta, Reeshu, Arora, Kajal, Roy, Sourav Singha, Joseph, Abyson, Rastogi, Ruchir, Arora, Nupur Mehrotra, Kundu, Prabuddha K.

DOI: https://doi.org/10.3389/fimmu.2023.1123805

Paper

Construction of PR39 recombinant AAV under control of the HRE promoter and the effect of recombinant AAV on gene therapy of ischemic heart disease.

Sun, Lijun, Hao, Yuewen, Nie, Xiaowei, Zhang, Xuexin, Yang, Guangxiao, Wang, Quanying · 2012

Full title: Construction of PR39 recombinant AAV under control of the HRE promoter and the effect of recombinant AAV on gene therapy of ischemic heart disease.

Authors: Sun, Lijun, Hao, Yuewen, Nie, Xiaowei, Zhang, Xuexin, Yang, Guangxiao, Wang, Quanying

DOI: https://doi.org/10.3892/etm.2012.674

Paper

Transgene Expression in Cultured Cells Using Unpurified Recombinant Adeno-Associated Viral Vectors

Benyamini, Brian, Esbin, Meagan N., Whitney, Oscar N., Walther, Nike, Maurer, Anna C. · 2023

Full title: Transgene Expression in Cultured Cells Using Unpurified Recombinant Adeno-Associated Viral Vectors

Authors: Benyamini, Brian, Esbin, Meagan N., Whitney, Oscar N., Walther, Nike, Maurer, Anna C.

DOI: https://doi.org/10.1101/2023.03.20.533580

Paper

Development of AAV-mediated gene therapy for autosomal recessive bestrophinopathy

Wood, Shaun · 2017

Full title: Development of AAV-mediated gene therapy for autosomal recessive bestrophinopathy

Authors: Wood, Shaun

DOI: https://doi.org/10.5287/ora-1475jodo5

Paper

Engineered CHO cells as a novel AAV production platform for gene therapy delivery

Nagy, Abdou, Chakrabarti, Lina, Kurasawa, James, Mulagapati, Sri Hari Raju, Devine, Paul N., Therres, Jamy, Chen, Yuyan, Schmelzer, Albert E. · 2023

Full title: Engineered CHO cells as a novel AAV production platform for gene therapy delivery

Authors: Nagy, Abdou, Chakrabarti, Lina, Kurasawa, James, Mulagapati, Sri Hari Raju, Devine, Paul N., Therres, Jamy, Chen, Yuyan, Schmelzer, Albert E.

DOI: https://doi.org/10.1038/s41598-023-46298-3

Paper

CRISPR/Cas9 as an antiviral against Orthopoxviruses using an AAV vector.

Siegrist, Cathryn M, Kinahan, Sean M, Settecerri, Taylor, Greene, Adrienne C, Santarpia, Joshua L · 2020

Full title: CRISPR/Cas9 as an antiviral against Orthopoxviruses using an AAV vector.

Authors: Siegrist, Cathryn M, Kinahan, Sean M, Settecerri, Taylor, Greene, Adrienne C, Santarpia, Joshua L

DOI: https://doi.org/10.1038/s41598-020-76449-9

Paper

High-purity AAV vector production utilizing recombination-dependent minicircle formation and genetic coupling.

Liu, Hao, Liu, Nan, Zhou, Chen, Du, Ailing, Kapadia, Mayank, Tai, Phillip W L, Barton, Erik, Gao, Guangping, Wang, Dan · 2025

Full title: High-purity AAV vector production utilizing recombination-dependent minicircle formation and genetic coupling.

Authors: Liu, Hao, Liu, Nan, Zhou, Chen, Du, Ailing, Kapadia, Mayank, Tai, Phillip W L, Barton, Erik, Gao, Guangping, Wang, Dan

DOI: https://doi.org/10.1038/s44321-025-00248-w

Paper

Nano-vesicles for gene delivery

Tan, Karen Li Ping · 2006

Full title: Nano-vesicles for gene delivery

Authors: Tan, Karen Li Ping

DOI: https://doi.org/10.32657/10356/2194

Paper

An Overview of Methods and Tools for Transfection of Eukaryotic Cells in vitro

Fus-Kujawa, Agnieszka, Pruś, Paweł, Bajdak-Rusinek, Karolina, Teper, Paulina, Gawron, Katarzyna, Kowalczuk, Agnieszka, Sieroń, Aleksander L. · 2021

Full title: An Overview of Methods and Tools for Transfection of Eukaryotic Cells in vitro

Authors: Fus-Kujawa, Agnieszka, Pruś, Paweł, Bajdak-Rusinek, Karolina, Teper, Paulina, Gawron, Katarzyna, Kowalczuk, Agnieszka, Sieroń, Aleksander L.

DOI: https://doi.org/10.3389/fbioe.2021.701031

Paper

Targeted knockdown of ATM, ATR, and PDEδ increases Gag HIV-1 VLP production in HEK293 cells

Díaz‐Maneh, Andy, Pérez‐Rubio, Pol, Granés, Cristina Rigau, Bosch-Molist, Laia, Lavado‐García, Jesús, Gòdia, Francesc, Cervera, Laura · 2025

Full title: Targeted knockdown of ATM, ATR, and PDEδ increases Gag HIV-1 VLP production in HEK293 cells

Authors: Díaz‐Maneh, Andy, Pérez‐Rubio, Pol, Granés, Cristina Rigau, Bosch-Molist, Laia, Lavado‐García, Jesús, Gòdia, Francesc, Cervera, Laura

DOI: https://doi.org/10.1007/s00253-024-13389-8

Paper

Targeted UDP-glucose ceramide glucosyltransferase stable overexpression induces a metabolic switch improving cell performance at high cell density.

Rahimi, Marzia, Nielsen, Lars K, Lavado-García, Jesús · 2025

Full title: Targeted UDP-glucose ceramide glucosyltransferase stable overexpression induces a metabolic switch improving cell performance at high cell density.

Authors: Rahimi, Marzia, Nielsen, Lars K, Lavado-García, Jesús

DOI: https://doi.org/10.3389/fbioe.2025.1690203

Paper

AAV process intensification by perfusion bioreaction and integrated clarification

Mendes, João P., Fernandes, Bárbara, Pineda, Earl, Kudugunti, Shashi, Bransby, Mike, Gantier, René, Peixoto, Cristina, Alves, Paula M., Roldão, António, Silva, Ricardo J. S. · 2022

Full title: AAV process intensification by perfusion bioreaction and integrated clarification

Authors: Mendes, João P., Fernandes, Bárbara, Pineda, Earl, Kudugunti, Shashi, Bransby, Mike, Gantier, René, Peixoto, Cristina, Alves, Paula M., Roldão, António, Silva, Ricardo J. S.

DOI: https://doi.org/10.3389/fbioe.2022.1020174

Paper

AAV Gene Therapy for MPS1-associated Corneal Blindness.

Vance, Melisa, Llanga, Telmo, Bennett, Will, Woodard, Kenton, Murlidharan, Giridhar, Chungfat, Neil, Asokan, Aravind, Gilger, Brian, Kurtzberg, Joanne, Samulski, R Jude, Hirsch, Matthew L · 2016

Full title: AAV Gene Therapy for MPS1-associated Corneal Blindness.

Authors: Vance, Melisa, Llanga, Telmo, Bennett, Will, Woodard, Kenton, Murlidharan, Giridhar, Chungfat, Neil, Asokan, Aravind, Gilger, Brian, Kurtzberg, Joanne, Samulski, R Jude, Hirsch, Matthew L

DOI: https://doi.org/10.1038/srep22131

Paper

Optimization of lentiviral vector production for scale-up in fixed-bed bioreactor

Valkama, Anniina J., Leinonen, Hanna, Lipponen, Eevi M., Turkki, Vesa, Malinen, Jukka, Heikura, Tommi, Ylä‐Herttuala, Seppo, Lesch, Hanna P. · 2017

Full title: Optimization of lentiviral vector production for scale-up in fixed-bed bioreactor

Authors: Valkama, Anniina J., Leinonen, Hanna, Lipponen, Eevi M., Turkki, Vesa, Malinen, Jukka, Heikura, Tommi, Ylä‐Herttuala, Seppo, Lesch, Hanna P.

DOI: https://doi.org/10.1038/gt.2017.91

Paper

Comparative transcriptomic and proteomic kinetic analysis of adeno-associated virus production systems.

Lin, Yu-Chieh, Lu, Min, Cai, Wen, Hu, Wei-Shou · 2024

Full title: Comparative transcriptomic and proteomic kinetic analysis of adeno-associated virus production systems.

Authors: Lin, Yu-Chieh, Lu, Min, Cai, Wen, Hu, Wei-Shou

DOI: https://doi.org/10.1007/s00253-024-13203-5

Paper

Proton-transfer-reaction mass spectrometry (PTR-MS) for online monitoring of glucose depletion and cell concentrations in HEK 293 gene therapy processes.

Bayer, Benjamin, Maccani, Andreas, Jahn, Johanna, Duerkop, Mark, Kapeller, Ewald, Pletzenauer, Robert, Kraus, Barbara, Striedner, Gerald, Hernandez Bort, Juan A · 2022

Full title: Proton-transfer-reaction mass spectrometry (PTR-MS) for online monitoring of glucose depletion and cell concentrations in HEK 293 gene therapy processes.

Authors: Bayer, Benjamin, Maccani, Andreas, Jahn, Johanna, Duerkop, Mark, Kapeller, Ewald, Pletzenauer, Robert, Kraus, Barbara, Striedner, Gerald, Hernandez Bort, Juan A

DOI: https://doi.org/10.1007/s10529-021-03205-y

Paper

Fast, efficient and virus-free generation of TRAC -replaced CAR T cells

Full title: Fast, efficient and virus-free generation of TRAC -replaced CAR T cells

DOI: https://doi.org/10.1101/2021.02.14.431017

Paper

With small viruses come giant responsibilities - Next-generation parvoviral vectors for human gene therapy with extended packaging capacity and enhanced safety profile

Fakhiri, Julia · 2019

Full title: With small viruses come giant responsibilities - Next-generation parvoviral vectors for human gene therapy with extended packaging capacity and enhanced safety profile

Authors: Fakhiri, Julia

DOI: https://doi.org/10.11588/heidok.00027326

Paper

Potent immunogenicity and neutralization of recombinant adeno-associated virus expressing the glycoprotein of severe fever with thrombocytopenia virus.

Shimoyama, Toshiaki, Oba, Mami, Takemae, Hitoshi, Omatsu, Tsutomu, Tani, Hideki, Mizutani, Tetsuya · 2024

Full title: Potent immunogenicity and neutralization of recombinant adeno-associated virus expressing the glycoprotein of severe fever with thrombocytopenia virus.

Authors: Shimoyama, Toshiaki, Oba, Mami, Takemae, Hitoshi, Omatsu, Tsutomu, Tani, Hideki, Mizutani, Tetsuya

DOI: https://doi.org/10.1292/jvms.23-0375

Paper

Adeno-Associated Viruses Serotype 2-Mediated RNA Interference Efficiently Inhibits Rabies Virus Replication In Vitro and In Vivo

Wu, Hongxia, Wang, Hualei, Guo, Xiaofeng, Yang, Yujiao, Ma, Jinzhu, Wang, Tiecheng, Gao, Yuwei, Zhao, Yongkun, Yang, Songtao, Xia, Xianzhu · 2013

Full title: Adeno-Associated Viruses Serotype 2-Mediated RNA Interference Efficiently Inhibits Rabies Virus Replication In Vitro and In Vivo

Authors: Wu, Hongxia, Wang, Hualei, Guo, Xiaofeng, Yang, Yujiao, Ma, Jinzhu, Wang, Tiecheng, Gao, Yuwei, Zhao, Yongkun, Yang, Songtao, Xia, Xianzhu

DOI: https://doi.org/10.1292/jvms.13-0127

Paper

Development of a CENH3-based and non-viral vector system

Fueloep, Stefanie · 2014

Full title: Development of a CENH3-based and non-viral vector system

Authors: Fueloep, Stefanie

DOI: https://doi.org/10.5282/edoc.16537

Paper

The membrane associated accessory protein is an adeno-associated viral egress factor

Elmore, Zachary C., Havlik, L. Patrick, Oh, Daniel K., Anderson, Leif, Daaboul, George G., Devlin, Garth, Vincent, Heather A., Asokan, Aravind · 2021

Full title: The membrane associated accessory protein is an adeno-associated viral egress factor

Authors: Elmore, Zachary C., Havlik, L. Patrick, Oh, Daniel K., Anderson, Leif, Daaboul, George G., Devlin, Garth, Vincent, Heather A., Asokan, Aravind

DOI: https://doi.org/10.1038/s41467-021-26485-4

Paper

Improving HEK293-based AAV-production using GSMMs, and a multi-omics approach

Full title: Improving HEK293-based AAV-production using GSMMs, and a multi-omics approach

DOI: https://doi.org/10.1101/2024.10.10.617556

Paper

Production of adeno-associated virus vectors for in vitro and in vivo applications

Full title: Production of adeno-associated virus vectors for in vitro and in vivo applications

DOI: https://doi.org/10.1038/s41598-019-49624-w

Paper

A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis

Prakash, Satya, Shao, M., Paul, Arghya, Abbasi, Sana, Chahal, Parminder S., Mena, Jimmy A., Montes, Johnny, Kamen, Amine · 2012

Full title: A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis

Authors: Prakash, Satya, Shao, M., Paul, Arghya, Abbasi, Sana, Chahal, Parminder S., Mena, Jimmy A., Montes, Johnny, Kamen, Amine

DOI: https://doi.org/10.2147/ijn.s26891

Paper

Bioprocess Development and Bioreactor Scale-Up for the Production of Recombinant Lentiviral Viral Vectors in HEK293 Suspension Cell Culture

Robitaille, Julien, Manceur, Aziza, Rodenbrock, Anja, Loignon, Martin · 2024

Full title: Bioprocess Development and Bioreactor Scale-Up for the Production of Recombinant Lentiviral Viral Vectors in HEK293 Suspension Cell Culture

Authors: Robitaille, Julien, Manceur, Aziza, Rodenbrock, Anja, Loignon, Martin

DOI: https://doi.org/10.5772/intechopen.114000

Paper

Synergistic Effect of Cationic Lipids with Different Polarheads, Central Core Structures and Hydrophobic Tails on Gene Transfection Efficiency

Niyomtham, Nattisa, Apiratikul, Nuttapon, Chanchang, Kanyarat, Opanasopit, Praneet, Yingyongnarongkul, Boon‐ek · 2014

Full title: Synergistic Effect of Cationic Lipids with Different Polarheads, Central Core Structures and Hydrophobic Tails on Gene Transfection Efficiency

Authors: Niyomtham, Nattisa, Apiratikul, Nuttapon, Chanchang, Kanyarat, Opanasopit, Praneet, Yingyongnarongkul, Boon‐ek

DOI: https://doi.org/10.1248/bpb.b14-00349

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Factors affecting rAAV titers during triple-plasmid transient transfection in HEK-293 cells.

Pistek, Martina, Andorfer, Peter, Grabherr, Reingard, Kraus, Barbara, Hernandez Bort, Juan A · 2024

Full title: Factors affecting rAAV titers during triple-plasmid transient transfection in HEK-293 cells.

Authors: Pistek, Martina, Andorfer, Peter, Grabherr, Reingard, Kraus, Barbara, Hernandez Bort, Juan A

DOI: https://doi.org/10.1007/s10529-024-03520-0

Paper

Analysis of the impact of pluronic acid on the thermal stability and infectivity of AAV6.2FF.

Thomas, Sylvia P, Spinelli, Marcus M, Rghei, Amira D, Lopes, Jordyn A, Zielinska, Nicole, McLeod, Benjamin M, Pei, Yanlong, Zhang, Wei, Thebaud, Bernard, Karimi, Khalil, Wootton, Sarah K · 2024

Full title: Analysis of the impact of pluronic acid on the thermal stability and infectivity of AAV6.2FF.

Authors: Thomas, Sylvia P, Spinelli, Marcus M, Rghei, Amira D, Lopes, Jordyn A, Zielinska, Nicole, McLeod, Benjamin M, Pei, Yanlong, Zhang, Wei, Thebaud, Bernard, Karimi, Khalil, Wootton, Sarah K

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Viral vector production in the integrity® iCELLis® single-use fixed-bed bioreactor, from bench-scale to industrial scale

Lennaertz, Alexandre, Knowles, Shane, Drugmand, Jean‐Christophe, Castillo, José · 2013

Full title: Viral vector production in the integrity® iCELLis® single-use fixed-bed bioreactor, from bench-scale to industrial scale

Authors: Lennaertz, Alexandre, Knowles, Shane, Drugmand, Jean‐Christophe, Castillo, José

DOI: https://doi.org/10.1186/1753-6561-7-s6-p59

Paper

A comparison of synthetic oligodeoxynucleotides, DNA fragments and AAV-1 for targeted episomal and chromosomal gene repair

Leclerc, X., Danos, Olivier, Scherman, Daniel, Kichler, Antoine · 2009

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Full title: Adeno-associated virus capsid assembly is divergent and stochastic

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Full title: Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation

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AAV-Vectored Immunoprophylaxis for the Prevention and Treatment of Infectious Diseases

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Development and characterization of an improved formulation of cholesteryl oleate-loaded cationic solid-lipid nanoparticles as an efficient non-viral gene delivery system

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Full title: Development and characterization of an improved formulation of cholesteryl oleate-loaded cationic solid-lipid nanoparticles as an efficient non-viral gene delivery system

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Thesis

In vitro and ex vivo strategies for intracellular delivery

Sahay, Gaurav; Stewart, Martin P; Sharei, Armon Reza et al. · 2017

Full title: In vitro and ex vivo strategies for intracellular delivery

Authors: Sahay, Gaurav; Stewart, Martin P; Sharei, Armon Reza; Ding, Xiaoyun Sean; Langer, Robert S; Jensen, Klavs F

DOI: http://hdl.handle.net/1721.1/110923

Thesis

Endogenous UMIs as quantifiable reporter elements – validation studies & applications in rAAV vectorology

Wilmott, Patrick Gurney · 2023

Full title: Endogenous UMIs as quantifiable reporter elements – validation studies & applications in rAAV vectorology

Authors: Wilmott, Patrick Gurney

DOI: https://hdl.handle.net/2123/31622

Thesis

Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis

Vergleich dreier Vektorsysteme für den koronaren Gentransfer

Sack, Philipp Andreas · 2010

Full title: Vergleich dreier Vektorsysteme für den koronaren Gentransfer

Authors: Sack, Philipp Andreas

DOI: https://mediatum.ub.tum.de/602308

Thesis

Improving AAV Retinal Gene Therapy for Batten Disease

Schwartz, Maura Katherine · 2022

Full title: Improving AAV Retinal Gene Therapy for Batten Disease

Authors: Schwartz, Maura Katherine

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1669911156168454

Thesis

Rekombinante Hepatitis B Viren-Vektoren als Werkzeuge für Molekularbiologie und Therapie : Optimierung eines Systems

Untergasser, Andreas · 2003

Full title: Rekombinante Hepatitis B Viren-Vektoren als Werkzeuge für Molekularbiologie und Therapie : Optimierung eines Systems

Authors: Untergasser, Andreas

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/3121/1/Promotion.pdf

Thesis

LARGE GENE DELIVERY TO THE RETINA BY MULTIPLE AAV VECTORS

TORNABENE, PATRIZIA · 2019

Full title: LARGE GENE DELIVERY TO THE RETINA BY MULTIPLE AAV VECTORS

Authors: TORNABENE, PATRIZIA

DOI: http://hdl.handle.net/2434/608611

Thesis

Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Murayyan, Abdulmonem · 2013

Full title: Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Authors: Murayyan, Abdulmonem

DOI: http://hdl.handle.net/10214/6604

Thesis

Bioprocess Engineering for HIV-1 Gag VLP Production in HEK293 Cells

Lavado García, Jesús · 2022

Full title: Bioprocess Engineering for HIV-1 Gag VLP Production in HEK293 Cells

Authors: Lavado García, Jesús

DOI: http://hdl.handle.net/10803/674392

Thesis

Development and optimization of the attB system to produce Helper-dependent Adenovirus vectors of different species

Cots i Rabella, Dan · 2014

Full title: Development and optimization of the attB system to produce Helper-dependent Adenovirus vectors of different species

Authors: Cots i Rabella, Dan

DOI: http://hdl.handle.net/10803/283431

Thesis

One for all, all for one: Combining and improving AAV, RNAi and CRISPR technologies to combat HBV infection and HBV/HDV co-infections

Schmelas, Carolin · 2020

Full title: One for all, all for one: Combining and improving AAV, RNAi and CRISPR technologies to combat HBV infection and HBV/HDV co-infections

Authors: Schmelas, Carolin

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/28513/1/Schmelas_Dissertation.pdf

Thesis

With small viruses come giant responsibilities - Next-generation parvoviral vectors for human gene therapy with extended packaging capacity and enhanced safety profile

Fakhiri, Julia · 2019

Full title: With small viruses come giant responsibilities - Next-generation parvoviral vectors for human gene therapy with extended packaging capacity and enhanced safety profile

Authors: Fakhiri, Julia

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/27326/1/PhD%20thesis%20Julia%20Fakhiri.pdf

Thesis

Transient transfection of serum-free suspension HEK 293 cell culture for efficient production of human rFVIII

Covas, Dimas Tadeu · 2011

Full title: Transient transfection of serum-free suspension HEK 293 cell culture for efficient production of human rFVIII

Authors: Covas, Dimas Tadeu

DOI: https://doi.org/10.1186/1472-6750-11-114

Thesis

Optimalizace rekombinantní exprese proteinů v HEK293 buněčné linii

Bláha, Jan · 2017

Full title: Optimalizace rekombinantní exprese proteinů v HEK293 buněčné linii

Authors: Bláha, Jan

DOI: http://hdl.handle.net/20.500.11956/29866

Thesis

Adeno-associated virus (AAV) transduction of primary human CD4+T lymphocytes

Kamel, Sahar Hussein · 2014

Full title: Adeno-associated virus (AAV) transduction of primary human CD4+T lymphocytes

Authors: Kamel, Sahar Hussein

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=wright1409957026

Thesis

A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing

Woodruff, Kristina; Maerkl, Sebastian J. · 2016

Full title: A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing

Authors: Woodruff, Kristina; Maerkl, Sebastian J.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/127380

Thesis

Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses

Fakhiri, Julia; Schneider, Marc A.; Puschhof, Jens et al. · 2019

Full title: Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses

DOI: https://dspace.library.uu.nl/handle/1874/439383

Thesis

Development of an Improved Transient Triple Transfection System with Focus on Engineering the Helper Plasmid for Enhanced rAAV Production

Pohle, Thilo · 2023

Full title: Development of an Improved Transient Triple Transfection System with Focus on Engineering the Helper Plasmid for Enhanced rAAV Production

Authors: Pohle, Thilo

DOI: https://etheses.whiterose.ac.uk/id/eprint/35606/1/PhDThesis_THP_final.pdf

Thesis

Herstellung optimierter Sf9-Zelllinien für die Baculovirus-basierte Produktion rekombinanter AAV5-Vektoren mit hoher Infektiosität

Casteleyn, Vincent · 2022

Full title: Herstellung optimierter Sf9-Zelllinien für die Baculovirus-basierte Produktion rekombinanter AAV5-Vektoren mit hoher Infektiosität

Authors: Casteleyn, Vincent

DOI: https://refubium.fu-berlin.de/handle/fub188/33543

Thesis

CELL ENGINEERING AND CULTURE MEDIA MODIFICATION STUDIES TO IMPROVE THE CELL CULTURE PERFORMANCE

Dhara, Venkata Gayatri · 2019

Full title: CELL ENGINEERING AND CULTURE MEDIA MODIFICATION STUDIES TO IMPROVE THE CELL CULTURE PERFORMANCE

Authors: Dhara, Venkata Gayatri

DOI: http://jhir.library.jhu.edu/handle/1774.2/60428

Thesis

Preparation and functionalization of magnetic iron oxide nanoparticles for application in gene delivery

Arsianti, Maria · 2010

Full title: Preparation and functionalization of magnetic iron oxide nanoparticles for application in gene delivery

Authors: Arsianti, Maria

DOI: http://hdl.handle.net/1959.4/50261

Thesis

Development of new strategies for efficient production and purification of recombinant adeno-associated virus (rAAV) vector /

Liu, Xingluo · 1999

Full title: Development of new strategies for efficient production and purification of recombinant adeno-associated virus (rAAV) vector /

Authors: Liu, Xingluo

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1488187049541563

Thesis

Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Blessing, Daniel; Vachey, Gabriel; Pythoud, Catherine et al. · 2019

Full title: Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Authors: Blessing, Daniel; Vachey, Gabriel; Pythoud, Catherine; Rey, Maria; Padrun, Vivianne; Wurm, Florian M.; Schneider, Bernard L.; Deglon, Nicole

DOI: https://infoscience.epfl.ch/handle/20.500.14299/158621

Thesis

Transient recombinant protein expression in mammalian cells : the role of mRNA level and stability

Wulhfard, Sarah · 2009

Full title: Transient recombinant protein expression in mammalian cells : the role of mRNA level and stability

Authors: Wulhfard, Sarah

DOI: https://infoscience.epfl.ch/handle/20.500.14299/36998

Thesis

Recombinant protein production by large-scale transient gene expression in mammalian cells : state of the art and future perspectives

Baldi, L; Hacker, DL; Adam, M et al. · 2007

Full title: Recombinant protein production by large-scale transient gene expression in mammalian cells : state of the art and future perspectives

Authors: Baldi, L; Hacker, DL; Adam, M; Wurm, FM

DOI: https://infoscience.epfl.ch/handle/20.500.14299/8764

Thesis

Production de vecteurs viraux efficaces pour la transduction de cellules transformées et de cellules primaires

Pilotte, Amélie · 2016

Full title: Production de vecteurs viraux efficaces pour la transduction de cellules transformées et de cellules primaires

Authors: Pilotte, Amélie

DOI: http://hdl.handle.net/1866/15572

Thesis

Optimisation and Application of Nanoelectroporation for Clonal β-Cell Transfection

Ekstrand, Frida · 2025

Full title: Optimisation and Application of Nanoelectroporation for Clonal β-Cell Transfection

Authors: Ekstrand, Frida

DOI: https://lup.lub.lu.se/record/097ab391-be95-4cc3-b370-b1ea33b8a03d

Thesis

Geração de clones de células HEK293 superprodutores de isoformas recombinantes de VEGF-A (Fator de Crescimento Endotelial Vascular A) humano visando à produção de biofármacos para terapia molecular e engenharia tecidual

Sogayar, Mari Cleide · 2014

Authors: Sogayar, Mari Cleide

DOI: http://www.teses.usp.br/teses/disponiveis/46/46131/tde-01102014-145602/

Thesis

Retroviral transduction of hematopoietic stem cells : optimisation of parameters for transduction

Wotherspoon, Simon Lance · 2005

Full title: Retroviral transduction of hematopoietic stem cells : optimisation of parameters for transduction

Authors: Wotherspoon, Simon Lance

DOI: http://hdl.handle.net/1959.4/66240

Thesis

Targeted lentiviral vectors pseudotyped with the Tupaia paramyxovirus glycoproteins

Enkirch, Theresa · 2011

Full title: Targeted lentiviral vectors pseudotyped with the Tupaia paramyxovirus glycoproteins

Authors: Enkirch, Theresa

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/12946/1/DrArbeit_FINAL_Theresa.pdf

Thesis

Lipid nanoparticle-mediated messenger RNA delivery for ex vivo engineering of natural killer cells

Douka, Stefania; Brandenburg, Lisa E; Casadidio, Cristina et al. · 2023

Full title: Lipid nanoparticle-mediated messenger RNA delivery for ex vivo engineering of natural killer cells

DOI: https://dspace.library.uu.nl/handle/1874/432851

Thesis

Vývoj techniky pro transfer genů do T-lymfocytů pomocí polyomavirových struktur a peptidu LAH4

Schreiberová, Lucie · 2020

Full title: Vývoj techniky pro transfer genů do T-lymfocytů pomocí polyomavirových struktur a peptidu LAH4

Authors: Schreiberová, Lucie

DOI: http://hdl.handle.net/20.500.11956/122022

Thesis

Strategies for improving production levels of HIV-1 VLPs by transient transfection of HEK 293 suspension cultures

Cervera Garcia, Laura · 2015

Full title: Strategies for improving production levels of HIV-1 VLPs by transient transfection of HEK 293 suspension cultures

Authors: Cervera Garcia, Laura

DOI: http://hdl.handle.net/10803/289626

Thesis

Scalable Production of Genome-Edited Livestock Embryos

Lin, Jason Chen · 2022

Full title: Scalable Production of Genome-Edited Livestock Embryos

Authors: Lin, Jason Chen

DOI: https://escholarship.org/uc/item/8hs7x39z

Thesis

Characterisation of cellular responses and gene delivery capabilities within porous agarose scaffolds

Sullivan, Matthew Scott · 2024

Full title: Characterisation of cellular responses and gene delivery capabilities within porous agarose scaffolds

Authors: Sullivan, Matthew Scott

DOI: https://etheses.whiterose.ac.uk/id/eprint/35132/1/M%20S%20Sullivan%202024.pdf

Thesis

Optimising adeno associated virus mediated gene therapy

Mallik, Shreyashee · 2023

Full title: Optimising adeno associated virus mediated gene therapy

Authors: Mallik, Shreyashee

DOI: https://hdl.handle.net/2123/31477

Thesis

Factors affecting AAV production: Mutagenesis of AAV2 rep and AAV transgenes

Jain, Nina Kumari · 2024

Full title: Factors affecting AAV production: Mutagenesis of AAV2 rep and AAV transgenes

Authors: Jain, Nina Kumari

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37377871

Thesis

Alternative Produktion rekombinanter Adeno-assoziierter Viren für die Gentherapie

Kuhrs, Annette · 2006

Full title: Alternative Produktion rekombinanter Adeno-assoziierter Viren für die Gentherapie

Authors: Kuhrs, Annette

DOI: https://refubium.fu-berlin.de/handle/fub188/12369

Thesis

High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells

Hildinger, Markus; Baldi, Lucia; Stettler, Matthieu et al. · 2019

Full title: High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells

Authors: Hildinger, Markus; Baldi, Lucia; Stettler, Matthieu; Wurm, Florian M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/160357

Thesis

Genome engineering in vivo for modeling of human diseases enhanced by AVV technology

Nickl, Petr · 2025

Full title: Genome engineering in vivo for modeling of human diseases enhanced by AVV technology

Authors: Nickl, Petr

DOI: http://hdl.handle.net/20.500.11956/196257

Thesis

The kinetics of polyethylenimine-mediated transfection in suspension cultures of Chinese hamster ovary cells

Bertschinger, Martin; Schertenleib, Arnaud; Cevey, Jean et al. · 2010

Full title: The kinetics of polyethylenimine-mediated transfection in suspension cultures of Chinese hamster ovary cells

Authors: Bertschinger, Martin; Schertenleib, Arnaud; Cevey, Jean; Hacker, David L.; Wurm, Florian M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/58359

Thesis

Epi-CHO, an episomal expression system for recombinant protein production in CHO cells

Kunaparaju, Raj Kumar · 2008

Full title: Epi-CHO, an episomal expression system for recombinant protein production in CHO cells

Authors: Kunaparaju, Raj Kumar

DOI: http://hdl.handle.net/1959.4/41499

Thesis

Systems Engineering for Viral Vector Manufacturing

Nguyen, Tam Ngoc Thanh · 2023

Full title: Systems Engineering for Viral Vector Manufacturing

Authors: Nguyen, Tam Ngoc Thanh

DOI: https://hdl.handle.net/1721.1/150243

Thesis

Optimalizace expresního systému HEK293 buněčné linie pomocí regulace buněčného cyklu a apoptózy

Poláchová, Edita · 2017

Full title: Optimalizace expresního systému HEK293 buněčné linie pomocí regulace buněčného cyklu a apoptózy

Authors: Poláchová, Edita

DOI: http://hdl.handle.net/20.500.11956/68567

Thesis

Weighing the DNA Content of Adeno-Associated Virus Vectors with Zeptogram Precision Using Nanomechanical Resonators

Katsikis, Georgios; Hwang, Iris E; Wang, Wade et al. · 2023

Full title: Weighing the DNA Content of Adeno-Associated Virus Vectors with Zeptogram Precision Using Nanomechanical Resonators

DOI: https://hdl.handle.net/1721.1/146983

Thesis

AAV capsid bioengineering in primary human retina models

Westhaus, A; Eamegdool, SS; Fernando, M et al. · 2024

Full title: AAV capsid bioengineering in primary human retina models

DOI: https://hdl.handle.net/11343/344430

Thesis

Multidose transient transfection of human embryonic kidney 293 cells modulates recombinant adeno‐associated virus2/5 Rep protein expression and influences the enrichment fraction of filled capsids

Srinivasan, Prasanna; Canova, Christopher T; Sha, Sha et al. · 2024

DOI: https://hdl.handle.net/1721.1/157695

Thesis

Analysis of Infection Relevant Protein Domains of the Adeno-Associated Virus Serotype 8 in Comparison to Serotype 2

Raupp, Christina · 2010

Full title: Analysis of Infection Relevant Protein Domains of the Adeno-Associated Virus Serotype 8 in Comparison to Serotype 2

Authors: Raupp, Christina

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/10925/1/complete_CRAUPPdiss.pdf

Thesis

The design, development and characterization of a self-replicating DNA expression technology

de Moor, Warren Ralph Josephus · 2022

Full title: The design, development and characterization of a self-replicating DNA expression technology

Authors: de Moor, Warren Ralph Josephus

DOI: http://hdl.handle.net/11427/36847

Thesis

Production and pharmaceutical formulation of plasmid DNA vaccines

van der Heijden, I. · 2013

Full title: Production and pharmaceutical formulation of plasmid DNA vaccines

Authors: van der Heijden, I.

DOI: https://dspace.library.uu.nl/handle/1874/283165

Thesis

The effect of cell penetrating peptides on transfection activity and cytotoxicity of polyallylamine

Sabouri-Rad, S; Oskuee, RK; Mahmoodi, A et al. · 2021

Full title: The effect of cell penetrating peptides on transfection activity and cytotoxicity of polyallylamine

Authors: Sabouri-Rad, S; Oskuee, RK; Mahmoodi, A; Gholami, L; Malaekeh-Nikouei, B

DOI: https://hdl.handle.net/11343/277463

Thesis

Study of transposon-mediated cell pool and cell line generation in CHO cells

Balasubramanian, Sowmya · 2015

Full title: Study of transposon-mediated cell pool and cell line generation in CHO cells

Authors: Balasubramanian, Sowmya

DOI: https://infoscience.epfl.ch/handle/20.500.14299/113896

Thesis

Correcting CPS1 Deficiency in Primary Human Hepatocytes In Vivo Using AAV Delivered Cell-Cycle Independent Targeted Genome Editing

Christina, Sharntie · 2024

Full title: Correcting CPS1 Deficiency in Primary Human Hepatocytes In Vivo Using AAV Delivered Cell-Cycle Independent Targeted Genome Editing

Authors: Christina, Sharntie

DOI: https://hdl.handle.net/2123/32857

Thesis

Study and characterisation of human HEK293 cell line as a platform for recombinant protein production

Liste Calleja, Leticia · 2015

Full title: Study and characterisation of human HEK293 cell line as a platform for recombinant protein production

Authors: Liste Calleja, Leticia

DOI: http://hdl.handle.net/10803/308324

Thesis

Development of an efficient, non-viral transfection method for studying gene function and bone growth in human primary cranial suture mesenchymal cells reveals that the cells respond to BMP2 and BMP3

Dwivedi, PP; Anderson, PJ; Powell, BC · 2022

Authors: Dwivedi, PP; Anderson, PJ; Powell, BC

DOI: https://hdl.handle.net/11343/304511

Thesis

Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Cosenza, Zachary Anthony · 2022

Full title: Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Authors: Cosenza, Zachary Anthony

DOI: https://escholarship.org/uc/item/119489fc

Thesis

Producing and Concentrating Lenti-Cre for Mouse Infections

Gierut, J. J.; Haigis, K. M.; Jacks, Tyler E. · 2018

Full title: Producing and Concentrating Lenti-Cre for Mouse Infections

Authors: Gierut, J. J.; Haigis, K. M.; Jacks, Tyler E.

DOI: http://hdl.handle.net/1721.1/116575

Thesis

Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions

Backliwal, G; Hildinger, M; Chenuet, S et al. · 2009

Full title: Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions

Authors: Backliwal, G; Hildinger, M; Chenuet, S; Wulhfard, S; De Jesus, M; Wurm, FM

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41410

Thesis

Comparison of CRISPR/Cas Endonucleases for in vivo Retinal Gene Editing

Li, F; Wing, K; Wang, JH et al. · 2020

Full title: Comparison of CRISPR/Cas Endonucleases for in vivo Retinal Gene Editing

Authors: Li, F; Wing, K; Wang, JH; Luu, CD; Bender, JA; Chen, J; Wang, Q; Lu, Q; Nguyen Tran, MT; Young, KM; Wong, RCB; Pébay, A; Cook, AL; Hung, SSC; Liu, GS; Hewitt, AW

DOI: https://hdl.handle.net/11343/251585

Thesis

Adeno-Associated Virus Vectors for Gene Therapy

Mietzsch, Mario · 2014

Full title: Adeno-Associated Virus Vectors for Gene Therapy

Authors: Mietzsch, Mario

DOI: https://refubium.fu-berlin.de/handle/fub188/6047

Thesis

Improving the immunogenicity of recombinant adeno-associated virus

Ussher, James Edgeworth · 2010

Full title: Improving the immunogenicity of recombinant adeno-associated virus

Authors: Ussher, James Edgeworth

DOI: https://hdl.handle.net/2292/6030

Thesis

Optimizing an Adeno-Associated Virus Vector System for Monogenic Diseases: Promoter Discovery and In Vivo Dosing Insights from a Neonatal Pig Model

Zielinska, Nicole · 2025

Full title: Optimizing an Adeno-Associated Virus Vector System for Monogenic Diseases: Promoter Discovery and In Vivo Dosing Insights from a Neonatal Pig Model

Authors: Zielinska, Nicole

DOI: https://hdl.handle.net/10214/29254

Thesis

Optmierung des Gentransfers in humane Keratinozyten mittels rekombinanter Adeno-assoziierter Virus Vektoren

Eisenried, Angelika · 2007

Full title: Optmierung des Gentransfers in humane Keratinozyten mittels rekombinanter Adeno-assoziierter Virus Vektoren

Authors: Eisenried, Angelika

DOI: https://mediatum.ub.tum.de/620611

Thesis

Identification and Validation of Target Receptors/Transporters for AAV9

Roach, Matthew · 2023

Full title: Identification and Validation of Target Receptors/Transporters for AAV9

Authors: Roach, Matthew

DOI: https://etheses.whiterose.ac.uk/id/eprint/33782/1/MatthewRoach_PhD_Thesis_with_corrections_MR%20edit.pdf

Thesis

Genetic Modification of Adeno-Associated Virus Capsid for Enhanced Motor Neuron Delivery and Retrograde Transport

Davis, Adam Scott · 2012

Full title: Genetic Modification of Adeno-Associated Virus Capsid for Enhanced Motor Neuron Delivery and Retrograde Transport

Authors: Davis, Adam Scott

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1351693788

Thesis

A study of apoptosis and cell cycle to augment transfection efficiency in CHO cell lines

Wanandy, Nico Stanislaus · 2007

Full title: A study of apoptosis and cell cycle to augment transfection efficiency in CHO cell lines

Authors: Wanandy, Nico Stanislaus

DOI: http://hdl.handle.net/1959.4/40868

Thesis

Expressão gênica empregando pseudopartículas em células de mamíferos (HEK 293T e Huh 7.0) cultivadas em diferentes meios de cultura livres de soro

Jorge, Soraia Attie Calil · 2016

Full title: Expressão gênica empregando pseudopartículas em células de mamíferos (HEK 293T e Huh 7.0) cultivadas em diferentes meios de cultura livres de soro

Authors: Jorge, Soraia Attie Calil

DOI: http://www.teses.usp.br/teses/disponiveis/87/87131/tde-24082016-113658/

Thesis

Adeno-associated virus rep78 expression in Arabidopsis thaliana

Sisco, Daniel · 2011

Full title: Adeno-associated virus rep78 expression in Arabidopsis thaliana

Authors: Sisco, Daniel

DOI: http://hdl.handle.net/10919/9706

Thesis

Evaluation of safety and methods for production of retroviral vectors for use in gene therapy

Kewney, Caroline · 1998

Full title: Evaluation of safety and methods for production of retroviral vectors for use in gene therapy

Authors: Kewney, Caroline

DOI: https://theses.gla.ac.uk/71502/7/10391130.pdf

Thesis

Adeno-Associated Virus Gene Therapy For Maple Syrup Urine Disease

Mullany, Kathryn Louise · 2025

Full title: Adeno-Associated Virus Gene Therapy For Maple Syrup Urine Disease

Authors: Mullany, Kathryn Louise

DOI: https://hdl.handle.net/2123/34263

Thesis

Enhancement of virus-like particle production in HEK293 cell cultures

Fuenmayor Garcés, Javier · 2018

Full title: Enhancement of virus-like particle production in HEK293 cell cultures

Authors: Fuenmayor Garcés, Javier

DOI: http://hdl.handle.net/10803/650410

Thesis

Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia et al. · 2012

Full title: Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76323

Thesis

Charakterisierung eines parvoviralen Hybridvektors hinsichtlich der Transduktion und präferentiellen Expression in transformierten Zellen

Krüger, Lars · 2005

Full title: Charakterisierung eines parvoviralen Hybridvektors hinsichtlich der Transduktion und präferentiellen Expression in transformierten Zellen

Authors: Krüger, Lars

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/5635/1/Dissertation_LK.pdf

Thesis

Untersuchungen zum Gentransfer in die Lunge mittels nicht-viraler Pulveraerosole und viraler Vektoren basierend auf dem Adeno-assoziierten Virus (AAV) 2/9

Pfeifer, Corinna · 2011

Full title: Untersuchungen zum Gentransfer in die Lunge mittels nicht-viraler Pulveraerosole und viraler Vektoren basierend auf dem Adeno-assoziierten Virus (AAV) 2/9

Authors: Pfeifer, Corinna

DOI: https://refubium.fu-berlin.de/handle/fub188/6992

Thesis

Identifizierung und Optimierung kritischer Schritte bei der Transfektion eukaryontischer Zellen

Schurig, Michael · 2009

Full title: Identifizierung und Optimierung kritischer Schritte bei der Transfektion eukaryontischer Zellen

Authors: Schurig, Michael

DOI: https://mediatum.ub.tum.de/667447

Thesis

Efficiency of transgene expression in bovine cells varies according to cell type and gene transfer method

Dias, Angelo José Burla · 2019

Full title: Efficiency of transgene expression in bovine cells varies according to cell type and gene transfer method

Authors: Dias, Angelo José Burla

DOI: https://doi.org/10.17533/udea.rccp.v32n1a04

Thesis

Production of AAV vectors for gene therapy : a cost-effectiveness and risk assessment

Rodríguez Pinhao Miessner, Diego · 2016

Full title: Production of AAV vectors for gene therapy : a cost-effectiveness and risk assessment

Authors: Rodríguez Pinhao Miessner, Diego

DOI: http://hdl.handle.net/1721.1/104215

Thesis

Correlation between cell cycle and calcium phosphate transient transfection of CHO cells

Grosjean, Frédéric · 2005

Full title: Correlation between cell cycle and calcium phosphate transient transfection of CHO cells

Authors: Grosjean, Frédéric

DOI: https://infoscience.epfl.ch/handle/20.500.14299/211990

Thesis

Produção de vetores lentivirais baseados em HIV-1 em linhagem de célula tronco mesenquimal murina

Silva, Flávia Helena da · 2007

Full title: Produção de vetores lentivirais baseados em HIV-1 em linhagem de célula tronco mesenquimal murina

Authors: Silva, Flávia Helena da

DOI: http://hdl.handle.net/10183/8134

Thesis

Design of a Novel Gene Therapy Construct to Achieve Sustained Brain-Derived Neurotrophic Factor Signaling in Neurons.

Osborne, Andrew; Wang, Aiden XZ; Tassoni, Alessia et al. · 2018

Full title: Design of a Novel Gene Therapy Construct to Achieve Sustained Brain-Derived Neurotrophic Factor Signaling in Neurons.

Authors: Osborne, Andrew; Wang, Aiden XZ; Tassoni, Alessia; Widdowson, Peter S; Martin, Keith R

DOI: https://www.repository.cam.ac.uk/handle/1810/274008

Thesis

Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

Muller, N.; Derouazi, M.; Van Tilborgh, F. et al. · 2007

Full title: Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

Authors: Muller, N.; Derouazi, M.; Van Tilborgh, F.; Wulhfard, S.; Hacker, D. L.; Jordan, M.; Wurm, F. M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9754

Thesis

Generation of recombinant Chinese hamster ovary cell lines by microinjection

Derouazi, M.; Flaction, R.; Girard, P. et al. · 2007

Full title: Generation of recombinant Chinese hamster ovary cell lines by microinjection

Authors: Derouazi, M.; Flaction, R.; Girard, P.; de Jesus, M.; Jordan, M.; Wurm, F. M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7686

Thesis

Quantitative analysis of non-viral gene therapy in primary liver culture systems

Tedford, Nathan C · 2008

Full title: Quantitative analysis of non-viral gene therapy in primary liver culture systems

Authors: Tedford, Nathan C

DOI: http://hdl.handle.net/1721.1/39914

Thesis

Développement de procédés efficaces pour la construction et la production de vecteurs adénoviraux

Gagnon, David · 2010

Full title: Développement de procédés efficaces pour la construction et la production de vecteurs adénoviraux

Authors: Gagnon, David

DOI: http://hdl.handle.net/1866/4462

Thesis

Impact of Formulation Conditions on Lipid Nanoparticle Characteristics and Functional Delivery of CRISPR RNP for Gene Knock-Out and Correction

Walther, Johanna; Wilbie, Danny; Tissingh, Vincent S.J. et al. · 2022

Full title: Impact of Formulation Conditions on Lipid Nanoparticle Characteristics and Functional Delivery of CRISPR RNP for Gene Knock-Out and Correction

Authors: Walther, Johanna; Wilbie, Danny; Tissingh, Vincent S.J.; Öktem, Mert; Van Der Veen, Heleen; Lou, Bo; Mastrobattista, Enrico

DOI: https://dspace.library.uu.nl/handle/1874/422276

Thesis

Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency

Sork, Helena; Nordin, Joel Z; Turunen, Janne J et al. · 2016

Full title: Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency

DOI: https://dspace.library.uu.nl/handle/1874/336850

Thesis

DEAE-Dextran Enhances the Lentiviral Transduction of Primary Human Mesenchymal Stromal Cells from All Major Tissue Sources Without Affecting Their Proliferation and Phenotype

Amadeo, Francesco; Hanson, Vivien; Murray, Patricia et al. · 2023

Full title: DEAE-Dextran Enhances the Lentiviral Transduction of Primary Human Mesenchymal Stromal Cells from All Major Tissue Sources Without Affecting Their Proliferation and Phenotype

Authors: Amadeo, Francesco; Hanson, Vivien; Murray, Patricia; Taylor, Arthur

DOI: https://livrepository.liverpool.ac.uk/3162174/1/library.pdf

Thesis

RECOMBINANT AAV6 GENE THERAPY VECTORS: PROCESS OPTIMIZATION AND SCALE UP INTO THE iCELLis NANO BIOREACTOR

Borges, Gwynneth · 2021

Full title: RECOMBINANT AAV6 GENE THERAPY VECTORS: PROCESS OPTIMIZATION AND SCALE UP INTO THE iCELLis NANO BIOREACTOR

Authors: Borges, Gwynneth

DOI: http://jhir.library.jhu.edu/handle/1774.2/63567

Thesis

Transient transfection induces different intracellular calcium signaling in CHO K1 versus HEK 293 cells

Preuss, A. K.; Connor, J. A.; Vogel, H. · 2019

Full title: Transient transfection induces different intracellular calcium signaling in CHO K1 versus HEK 293 cells

Authors: Preuss, A. K.; Connor, J. A.; Vogel, H.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/160503

Thesis

Možné přístupy k terapii cystické fibrosy

Král, Jan · 2019

Full title: Možné přístupy k terapii cystické fibrosy

Authors: Král, Jan

DOI: http://hdl.handle.net/20.500.11956/97888

Thesis

A Mechanistic Dissection of Polyethylenimine Mediated Transfection of Chinese Hamster Ovary Cells

Mozley, O L · 2013

Full title: A Mechanistic Dissection of Polyethylenimine Mediated Transfection of Chinese Hamster Ovary Cells

Authors: Mozley, O L

DOI: https://etheses.whiterose.ac.uk/id/eprint/5593/1/A%20mechanistic%20dissection%20of%20polyethylenimine%20mediated%20transfection%20of%20chinese%20hamster%20ovary%20cells.pdf

Thesis

Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel et al. · 2025

Full title: Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Authors: Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel; Dang, Brendan; Wolffe, Lenna A; Atari, Adel; Tseng, Yuen-Yi; Love, J Christopher

DOI: https://hdl.handle.net/1721.1/163220

Thesis

Gene modification and biotechnological applications of mesenchymal stem cells

Bosch, Pablo · 2024

Full title: Gene modification and biotechnological applications of mesenchymal stem cells

Authors: Bosch, Pablo

DOI: https://openscholar.uga.edu/record/20238/files/bosch_pablo_200508_phd.pdf

Thesis

Use of Transient Transfection for cGMP Manufacturing of eOD-GT8 60mer, a Self-Assembling Nanoparticle Germline-Targeting HIV-1 Vaccine Candidate

Sharma, Vaneet K.; Menis, Sergey; Brower, Evan T. et al. · 2024

Full title: Use of Transient Transfection for cGMP Manufacturing of eOD-GT8 60mer, a Self-Assembling Nanoparticle Germline-Targeting HIV-1 Vaccine Candidate

DOI: https://hdl.handle.net/1721.1/155438

Thesis

Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse

Kauffman, Kevin John; Oberli, Matthias; Dorkin, Joseph Robert et al. · 2019

Full title: Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse

DOI: https://hdl.handle.net/1721.1/122015

Thesis

Understanding the cell density effect upon transient transfection in HEK293 cell culture during HIV-1 VLP production

Pérez Rubio, Pol · 2024

Full title: Understanding the cell density effect upon transient transfection in HEK293 cell culture during HIV-1 VLP production

Authors: Pérez Rubio, Pol

DOI: http://hdl.handle.net/10803/693156

Thesis

Modified cell penetrating peptides for efficient gene transfer in vitro and in vivo

Osman, Gizem · 2017

Full title: Modified cell penetrating peptides for efficient gene transfer in vitro and in vivo

Authors: Osman, Gizem

DOI: https://eprints.nottingham.ac.uk/41863/1/00%20MASTER%20-%20G.Osman.pdf

Thesis

Transient gene expression for rapid protein production : studies & optimizations under serum-free conditions

Muller, Natalie · 2005

Full title: Transient gene expression for rapid protein production : studies & optimizations under serum-free conditions

Authors: Muller, Natalie

DOI: https://infoscience.epfl.ch/handle/20.500.14299/214287

Thesis

Structural, Viral, and Host Factors of Adeno-Associated Virus Assembly

Maurer, Anna · 2019

Full title: Structural, Viral, and Host Factors of Adeno-Associated Virus Assembly

Authors: Maurer, Anna

DOI: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42029713

Thesis

Desarrollo de procesos de producción de proteínas bioterapéuticas: Aumento de la productividad especifica en células HEK293

Román Roldán, Ramón · 2018

Full title: Desarrollo de procesos de producción de proteínas bioterapéuticas: Aumento de la productividad especifica en células HEK293

Authors: Román Roldán, Ramón

DOI: http://hdl.handle.net/10803/650828

Thesis

A novel AAV9 random peptide library to select for endothelial cell – directed gene transfer vectors

Varadi, Karl · 2011

Full title: A novel AAV9 random peptide library to select for endothelial cell – directed gene transfer vectors

Authors: Varadi, Karl

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/12542/1/Dissertation_Karl_Varadi.pdf

Thesis

Adeno-associated virus capsid assembly is divergent and stochastic

Wörner, Tobias P; Bennett, Antonette; Habka, Sana et al. · 2021

Full title: Adeno-associated virus capsid assembly is divergent and stochastic

Authors: Wörner, Tobias P; Bennett, Antonette; Habka, Sana; Snijder, Joost; Friese, Olga; Powers, Thomas; Agbandje-McKenna, Mavis; Heck, Albert J R

DOI: https://dspace.library.uu.nl/handle/1874/411860

Thesis

A comparison of intravenous and indirect intracoronary delivery of AAV5, AAV6 and AAV9 for cardiac gene transfer in mice

Fang, Hongfei · 2011

Full title: A comparison of intravenous and indirect intracoronary delivery of AAV5, AAV6 and AAV9 for cardiac gene transfer in mice

Authors: Fang, Hongfei

DOI: https://escholarship.org/uc/item/1024d4fh

Thesis

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Lee, John; Nist-Lund, Carl; Solanes, Paola et al. · 2020

Full title: Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Authors: Lee, John; Nist-Lund, Carl; Solanes, Paola; Goldberg, Hannah; Wu, Jason; Pan, Bifeng; Schneider, Bernard L.; Holt, Jeffrey R.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/171017

Thesis

Optimalizace kultivačního média HEK293 buněčné linie

Čuperková, Romana · 2017

Full title: Optimalizace kultivačního média HEK293 buněčné linie

Authors: Čuperková, Romana

DOI: http://hdl.handle.net/20.500.11956/45606

Thesis

Production of Virus-Like Particles in HEK 293 cells and functionalization with SARS-CoV-2

Boix i Besora, Arnau · 2022

Full title: Production of Virus-Like Particles in HEK 293 cells and functionalization with SARS-CoV-2

Authors: Boix i Besora, Arnau

DOI: http://hdl.handle.net/10803/675518

Thesis

A synthetic approach to produce recombinant adeno-associated virus (rAAV) in Chinese hamster ovary (CHO) cells

Cai, Wen · 2024

Full title: A synthetic approach to produce recombinant adeno-associated virus (rAAV) in Chinese hamster ovary (CHO) cells

Authors: Cai, Wen

DOI: https://hdl.handle.net/11299/259525

Thesis

Novel High-Throughput Methods to Study AAV Immunity Using Combinatorial Capsid Libraries

Schmit, Pauline Frances · 2021

Full title: Novel High-Throughput Methods to Study AAV Immunity Using Combinatorial Capsid Libraries

Authors: Schmit, Pauline Frances

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369455

Thesis

Utilização de shRNA anti-hexon, anti-IVa2 e anti-pol durante a produção de vírus adeno-associado como estratégia de eliminar Adenovírus helper:: prova de princípio

Strauss, Bryan Eric · 2016

Full title: Utilização de shRNA anti-hexon, anti-IVa2 e anti-pol durante a produção de vírus adeno-associado como estratégia de eliminar Adenovírus helper:: prova de princípio

Authors: Strauss, Bryan Eric

DOI: http://www.teses.usp.br/teses/disponiveis/5/5155/tde-13032017-101533/

Thesis

Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells

Nguyen, Tam N.T.; Sha, Sha; Hong, Moo Sun et al. · 2022

Full title: Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells

Authors: Nguyen, Tam N.T.; Sha, Sha; Hong, Moo Sun; Maloney, Andrew J.; Barone, Paul W.; Neufeld, Caleb; Wolfrum, Jacqueline; Springs, Stacy L.; Sinskey, Anthony J.; Braatz, Richard D.

DOI: https://hdl.handle.net/1721.1/135559.2

Thesis

Derivation of rep-positive adeno-associated virus vectors and analysis of site-specific integration /

Philpott, Jessica R. · 2000

Full title: Derivation of rep-positive adeno-associated virus vectors and analysis of site-specific integration /

Authors: Philpott, Jessica R.

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1488192119261715

Thesis

Untersuchung der zellspezifischen In-situ-Effizienz des Nukleinsäuretransfers in das Herzgewebe

Liu, Zihou · 2021

Full title: Untersuchung der zellspezifischen In-situ-Effizienz des Nukleinsäuretransfers in das Herzgewebe

Authors: Liu, Zihou

DOI: https://refubium.fu-berlin.de/handle/fub188/31132

Thesis

Study of the improved Sf9 transient gene expression process

Shen, Xiao; Hacker, David L.; Baldi, Lucia et al. · 2014

Full title: Study of the improved Sf9 transient gene expression process

Authors: Shen, Xiao; Hacker, David L.; Baldi, Lucia; Wurm, Florian M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/100125

Thesis

Non-viral gene delivery with pH-sensitive gemini nanoparticles : synthesis of gemini surfactant building blocks, characterization and in vitro screening of transfection efficiency and toxicity

Donkuru, McDonald · 2009

Authors: Donkuru, McDonald

DOI: http://hdl.handle.net/10388/etd-01132009-131423

Thesis

Enhancing Production of Recombinant Proteins from Mammalian Cells

Wong, Victor V.T.; Wong, Niki S.C.; Tan, Hong-Kiat et al. · 2003

Full title: Enhancing Production of Recombinant Proteins from Mammalian Cells

Authors: Wong, Victor V.T.; Wong, Niki S.C.; Tan, Hong-Kiat; Wang, Daniel I.C.; Yap, Miranda G.S.

DOI: http://hdl.handle.net/1721.1/3782

Thesis

Optimalizace rekombinantní exprese proteinů v lidské buněčné linii HEK293

Murajdová, Viktória · 2024

Full title: Optimalizace rekombinantní exprese proteinů v lidské buněčné linii HEK293

Authors: Murajdová, Viktória

DOI: http://hdl.handle.net/20.500.11956/194250

Thesis

Quantitative correlation between transcriptional levels of ER chaperone, peroximal protein and FVIII productivity in human Hek-293 cell line

Covas, Dimas Tadeu · 2013

Full title: Quantitative correlation between transcriptional levels of ER chaperone, peroximal protein and FVIII productivity in human Hek-293 cell line

Authors: Covas, Dimas Tadeu

DOI: https://doi.org/10.1186/2193-1801-2-328

Thesis

Evaluierung von Nukleoprotein-kodierenden AAV Vektoren als breitenwirksame Influenza-Impfstoffe

Fiddeke, Katharina · 2017

Full title: Evaluierung von Nukleoprotein-kodierenden AAV Vektoren als breitenwirksame Influenza-Impfstoffe

Authors: Fiddeke, Katharina

DOI: https://refubium.fu-berlin.de/handle/fub188/8958

Thesis

Adeno-Associated Virus Vector Development for Monoclonal Antibody Expression to Prevent Ebola Virus Infection

van Lieshout, Laura · 2018

Full title: Adeno-Associated Virus Vector Development for Monoclonal Antibody Expression to Prevent Ebola Virus Infection

Authors: van Lieshout, Laura

DOI: http://hdl.handle.net/10214/14680

Thesis

White-Box Approaches to Cell Culture Media Optimization for Cultivated Meat

O'Neill, Edward N · 2024

Full title: White-Box Approaches to Cell Culture Media Optimization for Cultivated Meat

Authors: O'Neill, Edward N

DOI: https://escholarship.org/uc/item/9920t5d7

Thesis

In Vivo Delivery and Therapeutic Applications of Base Editors

Yeh, Ariel (Wei-Hsi) · 2020

Full title: In Vivo Delivery and Therapeutic Applications of Base Editors

Authors: Yeh, Ariel (Wei-Hsi)

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37365751

Thesis

Optimisation of Delivery of the Ataxia Telangiectasia Mutated Transgene to HeLa Cells Using Glycosaminoglycan Enhanced Transduction

Siam, Ala'a · 2021

Full title: Optimisation of Delivery of the Ataxia Telangiectasia Mutated Transgene to HeLa Cells Using Glycosaminoglycan Enhanced Transduction

Authors: Siam, Ala'a

DOI: https://eprints.nottingham.ac.uk/66891/1/Ala%27a%20Siam%20-%20MRes%20Thesis.pdf

Thesis

Advanced Process Development in Gene and Cell Therapies

Ladd, Brian · 2025

Full title: Advanced Process Development in Gene and Cell Therapies

Authors: Ladd, Brian

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-360154

Thesis

Development of a Novel Dual AAV System for Therapeutic Delivery of BDNF

Cheng, Yuhsiang · 2018

Full title: Development of a Novel Dual AAV System for Therapeutic Delivery of BDNF

Authors: Cheng, Yuhsiang

DOI: https://escholarship.org/uc/item/3v16w70m

Thesis

Advances in crustacean cell culture

Claydon, Kerry · 2009

Full title: Advances in crustacean cell culture

Authors: Claydon, Kerry

DOI: https://researchonline.jcu.edu.au/11946/11/JCU_11946_Claydon_2009_thesis.pdf

Thesis

Semliki Forest Virus as a Vector: Pros and Cons for Its Use in Biopharmaceuticals Production

Fernández Núñez, Eutimio Gustavo [UNESP]; Calil Jorge, Soraia Attie; Astray, Renato Mancini et al. · 2014

Full title: Semliki Forest Virus as a Vector: Pros and Cons for Its Use in Biopharmaceuticals Production

DOI: http://dx.doi.org/10.1590/S1516-89132013000500018

Thesis

Enhanced efficiency of lactosylated poly-L-lysine-mediated gene transfer into cystic fibrosis airway epithelial cells

Vliegenthart, J.F.G.; Knollen, W.J.W.; Schembri, F.M. et al. · 1999

Full title: Enhanced efficiency of lactosylated poly-L-lysine-mediated gene transfer into cystic fibrosis airway epithelial cells

Authors: Vliegenthart, J.F.G.; Knollen, W.J.W.; Schembri, F.M.; Gerwig, G.J.; Glick, M.C.; Scanlin, T.F.

DOI: https://dspace.library.uu.nl/handle/1874/5327

Thesis

Perfusion‐Based Production of rAAV via an Intensified Transient Transfection Process

Nguyen, Tam NT; Park, Damdae; Canova, Christopher T et al. · 2025

Full title: Perfusion‐Based Production of rAAV via an Intensified Transient Transfection Process

DOI: https://hdl.handle.net/1721.1/162858

Thesis

Development of a Lentiviral Vector for High-Yield Production of Synthetic and Recombinant GCase for Gaucher Disease Therapy

Coelho, Ana Carolina; Wiezel, Claudia Emília Vieira; de Campos, Alline Cristina et al. · 2025

Full title: Development of a Lentiviral Vector for High-Yield Production of Synthetic and Recombinant GCase for Gaucher Disease Therapy

DOI: https://hdl.handle.net/1721.1/162371

Thesis

Establishment of recombinant mammalian cell lines : new approaches

Derouazi, Madiha · 2005

Full title: Establishment of recombinant mammalian cell lines : new approaches

Authors: Derouazi, Madiha

DOI: https://infoscience.epfl.ch/handle/20.500.14299/212504

Thesis

Transduktion av plasmid-komplex genom cellmembran med hjälp av akustofluidisk infångning

Eriksson, John · 2024

Full title: Transduktion av plasmid-komplex genom cellmembran med hjälp av akustofluidisk infångning

Authors: Eriksson, John

DOI: http://lup.lub.lu.se/student-papers/record/9162786

Thesis

Analysis of the Effects of RAS-MAPK Pathway Modulatory Adeno-associated Viral Vectors

Volz, Avery · 2024

Full title: Analysis of the Effects of RAS-MAPK Pathway Modulatory Adeno-associated Viral Vectors

Authors: Volz, Avery

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1721145531361946

Thesis

Construction and characterization of stable cell lines that generate recombinant adeno-associated virus (rAAV) /

Voulgaropoulou, Frosso · 1996

Full title: Construction and characterization of stable cell lines that generate recombinant adeno-associated virus (rAAV) /

Authors: Voulgaropoulou, Frosso

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1487942476408687

Thesis

The development of viral vectors for targeted gene delivery to atherosclerotic plaques

White, Katie · 2007

Full title: The development of viral vectors for targeted gene delivery to atherosclerotic plaques

Authors: White, Katie

DOI: https://theses.gla.ac.uk/30729/1/2007WhitePhD.pdf

Thesis

Formulation and delivery of dermal DNA vaccines

van den Berg, J.H. · 2009

Full title: Formulation and delivery of dermal DNA vaccines

Authors: van den Berg, J.H.

DOI: https://dspace.library.uu.nl/handle/1874/36212

Thesis

Molecular characterization of the avian adeno-associated virus and its use for the development of a viral vector system

Estevez, Carlos · 2024

Full title: Molecular characterization of the avian adeno-associated virus and its use for the development of a viral vector system

Authors: Estevez, Carlos

DOI: https://openscholar.uga.edu/record/9951/files/estevez_carlos_n_200405_phd.pdf

Thesis

Evaluating Lung Gene Therapy Viral Vector Platforms using Precision-cut Lung Slices as an ex vivo Model

Stevens, Brenna · 2025

Full title: Evaluating Lung Gene Therapy Viral Vector Platforms using Precision-cut Lung Slices as an ex vivo Model

Authors: Stevens, Brenna

DOI: https://hdl.handle.net/10214/29367

Thesis

Novel Extracellular Vesicle Modalities for Delivery of Genome Editor Ribonucleoprotein Complexes

Cabeceiras, Peter Keith · 2022

Full title: Novel Extracellular Vesicle Modalities for Delivery of Genome Editor Ribonucleoprotein Complexes

Authors: Cabeceiras, Peter Keith

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372269

Thesis

Conception et évaluation d’un nouveau système de transfection ciblée, basé sur l’utilisation du système E/Kcoil

Louvier, Elodie · 2016

Full title: Conception et évaluation d’un nouveau système de transfection ciblée, basé sur l’utilisation du système E/Kcoil

Authors: Louvier, Elodie

DOI: http://hdl.handle.net/1866/13031

Thesis

Generation of stable suspension producer cell lines for serum-free lentivirus production

Klimpel, M; Terrao, M; Bräuer, M et al. · 2024

Full title: Generation of stable suspension producer cell lines for serum-free lentivirus production

DOI: https://hdl.handle.net/11343/351064

Thesis

Magnetofection Potentiates Gene Delivery to Cultured Endothelial Cells

Krötz, Florian; Sohn, Hae-Young; Gloe, Torsten et al. · 2003

Full title: Magnetofection Potentiates Gene Delivery to Cultured Endothelial Cells

Authors: Krötz, Florian;Sohn, Hae-Young;Gloe, Torsten;Plank, Christian;Pohl, Ulrich

DOI: https://mediatum.ub.tum.de/1218851

Thesis

Glyco-engineered HEK 293-F cell lines to produce therapeutic glycoproteins with human N-glycosylation and improved pharmacokinetics

Uhler, Rico · 2022

Full title: Glyco-engineered HEK 293-F cell lines to produce therapeutic glycoproteins with human N-glycosylation and improved pharmacokinetics

Authors: Uhler, Rico

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/31087/1/PhD%20Thesis%20Rico%20Uhler.pdf

Thesis

Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

Zhang, Xiaowei; Garcia, Isabel Fernandez; Baldi, Lucia et al. · 2010

Full title: Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

Authors: Zhang, Xiaowei; Garcia, Isabel Fernandez; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/52051

Thesis

Engineering inducible cell lines for recombinant Adeno-Associated Virus production

Lee, Zion · 2021

Full title: Engineering inducible cell lines for recombinant Adeno-Associated Virus production

Authors: Lee, Zion

DOI: https://hdl.handle.net/11299/225020

Thesis

Serum-free suspension adaptation of HEK-293T cells: basis for large-scale biopharmaceutical production

Mizukami, Amanda · 2021

Full title: Serum-free suspension adaptation of HEK-293T cells: basis for large-scale biopharmaceutical production

Authors: Mizukami, Amanda

DOI: https://doi.org/10.1590/1678-4324-2021200817

Thesis

Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand

Chua, Gek Kee · 2011

Authors: Chua, Gek Kee

DOI: http://hdl.handle.net/10179/2832

Patent

us-2002045250-a1

· 2002

Full title: us-2002045250-a1

Patent

us-2021363498-a1

· 2021

Full title: us-2021363498-a1

Patent

us-12305188-b2

· 2025

Full title: us-12305188-b2

Patent

us-2023348936-a1

· 2023

Full title: us-2023348936-a1

Patent

us-10801042-b1

· 2020

Full title: us-10801042-b1

Patent

us-2024150728-a1

· 2024

Full title: us-2024150728-a1

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us-2023374540-a1

· 2023

Full title: us-2023374540-a1

Patent

us-2021163991-a1

· 2021

Full title: us-2021163991-a1

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us-11396663-b2

· 2022

Full title: us-11396663-b2

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us-6995006-b2

· 2006

Full title: us-6995006-b2

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us-7732129-b1

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Full title: us-7732129-b1

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us-2024101964-a1

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Full title: us-2024101964-a1

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us-2024084329-a1

· 2024

Full title: us-2024084329-a1

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us-2013224836-a1

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Full title: us-2013224836-a1

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us-2025313854-a1

· 2025

Full title: us-2025313854-a1

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us-2024287545-a1

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us-2020325455-a1

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us-2024425880-a1

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us-2011039339-a1

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us-11739347-b2

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us-11674156-b2

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us-11702673-b2

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us-2019017033-a1

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Full title: us-2019017033-a1

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us-2024052341-a1

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Full title: us-2024052341-a1

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us-2021348194-a1

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us-11078464-b2

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us-6086913-a

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us-2007155008-a1

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us-5780280-a

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us-2010248355-a1

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us-2024033345-a1

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us-9879229-b2

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us-2025145969-a1

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us-2021047650-a1

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us-12060569-b2

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us-2005266567-a1

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us-5994134-a

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us-11685932-b2

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us-2003008375-a1

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Full title: us-2003008375-a1

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us-2007065854-a1

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Full title: us-2007065854-a1

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us-2020270583-a1

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us-7271002-b2

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Full title: us-7271002-b2

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us-12234472-b2

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Full title: us-12234472-b2

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us-6696038-b1

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us-11667931-b2

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us-9353382-b2

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Full title: us-9353382-b2

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us-2024350663-a1

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Full title: us-2024350663-a1

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us-2019203184-a1

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Full title: us-2019203184-a1

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us-2022098555-a1

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Full title: us-2022098555-a1

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us-11834683-b2

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us-2020123572-a1

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us-6726907-b1

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us-2023128412-a1

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us-2020032221-a1

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us-2023055381-a1

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us-2025154524-a1

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us-11608491-b2

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us-2025188490-a1

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us-2016168590-a1

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us-2024101972-a1

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us-2011165620-a1

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us-11208630-b2

· 2021

Full title: us-11208630-b2

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us-5681731-a

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Full title: us-5681731-a

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us-2024076627-a1

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us-2002182723-a1

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us-2019290710-a1

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us-2020385689-a1

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us-2021054384-a1

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us-2022290182-a1

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us-2023272418-a1

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us-2024026306-a1

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us-2002160501-a1

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us-12077784-b2

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us-2024263143-a1

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us-2002115189-a1

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us-11780886-b2

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us-2024263149-a1

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us-2024026309-a1

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us-2024247218-a1

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us-2023013253-a1

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us-2025136999-a1

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us-6686200-b1

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us-2024167054-a1

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us-12344856-b2

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us-2025115929-a1

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us-2024327869-a1

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us-2004018627-a1

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us-2021292790-a1

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us-2023087751-a1

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us-2020010808-a1

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us-10858629-b2

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us-12188040-b2

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us-2022243225-a1

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us-10421950-b2

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us-2020048641-a1

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us-2021340503-a1

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us-6943019-b2

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us-2023090178-a1

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us-2023038295-a1

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us-2019055523-a1

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us-11898170-b2

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us-2023323395-a1

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us-2025250549-a1

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us-2021163544-a1

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us-2024002883-a1

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us-2003032176-a1

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us-2020325493-a1

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us-2024271107-a1

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us-12404526-b2

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us-2004121444-a1

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us-12398403-b2

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us-2007154447-a1

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us-2023407329-a1

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us-2020224173-a1

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us-12018288-b2

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us-2025230418-a1

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us-10273462-b2

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us-2002177215-a1

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Full title: us-2002177215-a1

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us-10815497-b2

· 2020

Full title: us-10815497-b2

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us-6027931-a

· 2000

Full title: us-6027931-a

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us-2025066744-a1

· 2025

Full title: us-2025066744-a1

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us-5658776-a

· 1997

Full title: us-5658776-a

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us-2022243224-a1

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us-9102943-b2

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us-2023365990-a1

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us-12104165-b2

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us-11781102-b2

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us-2010055763-a1

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us-2005287662-a1

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us-6566118-b1

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us-11827675-b2

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us-2008206812-a1

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us-2021277416-a1

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us-2024018547-a1

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us-6989264-b2

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us-5498537-a

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us-6365403-b1

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us-2020165632-a1

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us-12180511-b2

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us-8716399-b2

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us-2013171719-a1

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us-2005089999-a1

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us-2003148506-a1

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us-2024011048-a1

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us-8273344-b2

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us-2004248288-a1

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us-2021238632-a1

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us-2024376440-a1

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us-2024101971-a1

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us-2022364114-a1

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us-2008050770-a1

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us-7125706-b2

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us-2024132910-a1

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us-2023116968-a1

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us-2022290108-a1

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us-7579181-b2

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us-2019292561-a1

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us-2023193214-a1

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us-2023056355-a1

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us-2020325181-a1

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us-2024279682-a1

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us-11384364-b2

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us-10738326-b2

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us-2022186255-a1

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us-2023295656-a1

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us-8637315-b2

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us-2024117376-a1

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us-2020277628-a1

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us-2022025399-a1

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us-2019048362-a1

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us-11795473-b2

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us-2006003453-a1

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us-2023279427-a1

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us-12060567-b2

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us-2024093231-a1

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us-11718833-b2

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us-2024263148-a1

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us-6194191-b1

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us-2025320524-a1

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us-7510875-b2

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us-2016272687-a1

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us-12226473-b2

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us-2021395777-a1

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us-2002127582-a1

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us-2021348190-a1

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us-12410436-b2

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us-2025019669-a1

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us-2022154215-a1

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us-2023416307-a1

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us-2020165557-a1

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us-2019284576-a1

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us-6303371-b1

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us-2014004568-a1

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us-2021198695-a1

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Full title: us-2021198695-a1

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us-2018312872-a1

· 2018

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us-2007202587-a1

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us-11827907-b2

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us-2024360422-a1

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us-11884926-b2

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us-12116578-b2

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us-2021032657-a1

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us-2005170450-a1

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us-2016024480-a1

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us-8658150-b2

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us-6140103-a

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us-2023002739-a1

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us-7445930-b2

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us-2024360423-a1

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us-2023193312-a1

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us-2025043251-a1

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us-6168941-b1

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us-2024368564-a1

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us-6146874-a

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us-7183263-b2

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us-6383794-b1

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us-2025283109-a1

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us-6416992-b1

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us-2025084383-a1

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us-2022204945-a1

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us-2024141378-a1

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us-11708585-b2

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us-2023279433-a1

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us-2024141377-a1

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us-2021346493-a1

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us-7863470-b2

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us-12305189-b2

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us-2013095558-a1

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us-2025263746-a1

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us-2004137050-a1

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us-2013183719-a1

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us-2013029379-a1

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us-2008131403-a1

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us-2025207106-a1

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us-2019292563-a1

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us-6677155-b1

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us-2020208121-a1

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us-7485448-b2

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us-2013030119-a1

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us-2017362577-a1

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us-2014051170-a1

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us-2022282277-a1

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us-2019017068-a1

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us-2025034590-a1

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us-2024158759-a1

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us-2023242939-a1

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us-6660514-b1

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us-2025263747-a1

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us-11499141-b2

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