← Back to topics

Monoclonal Antibody Production Optimization In Cho

test

1. Documents

1177

237 papers 431 patents 509 theses

Full text available

Paper ALiCE®: A versatile, high yielding and scalable eukaryotic cell-free protein synthesis (CFPS) system

Mainak das Gupta; Yannick Flaskamp; Robin Roentgen et al. · 2022 · bioRxiv · DOI

Full title: ALiCE®: A versatile, high yielding and scalable eukaryotic cell-free protein synthesis (CFPS) system

Authors: Mainak das Gupta; Yannick Flaskamp; Robin Roentgen; Hannes Juergens; Jorge Armero Gimenez; F. Albrecht; Johannes Hemmerich; Zulfaquar Ahmad Arfi; Jakob Neuser; H. Spiegel; A. Yeliseev; Lusheng Song; J. Qiu; C. Williams; R. Finnern

Year: 2022

Venue: bioRxiv

DOI: https://doi.org/10.1101/2022.11.10.515920

Paper pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis

Adams, Richard R.; Tavares, Álvaro A.; Salzberg, Adi et al. · 1998 · Genes & Development · DOI

Full title: pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis

Authors: Adams, Richard R.; Tavares, Álvaro A.; Salzberg, Adi; Bellen, Hugo J.; Glover, David M.

Year: 1998

Venue: Genes & Development

DOI: https://doi.org/10.1101/gad.12.10.1483

Paper Efficient and reproducible generation of high-expressing, stable human cell lines without need for antibiotic selection

Schiedner, Gudrun; Hertel, Sabine; Bialek, Corinna et al. · 2008 · BMC Biotechnology · DOI

Full title: Efficient and reproducible generation of high-expressing, stable human cell lines without need for antibiotic selection

Authors: Schiedner, Gudrun; Hertel, Sabine; Bialek, Corinna; Kewes, Helmut; Waschütza, Gero; Volpers, Christoph

Year: 2008

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-8-13

Paper Establishment and mitotic stability of an extra-chromosomal mammalian replicon

Stehle, Isa M.; Postberg, Jan; Rupprecht, Sina et al. · 2007 · BMC Cell Biology · DOI

Full title: Establishment and mitotic stability of an extra-chromosomal mammalian replicon

Authors: Stehle, Isa M.; Postberg, Jan; Rupprecht, Sina; Cremer, Thomas; Jackson, Dean A.; Lipps, Hans J.

Year: 2007

Venue: BMC Cell Biology

DOI: https://doi.org/10.1186/1471-2121-8-33

Paper Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0

Teylaert, Béatrice; Meurice, Edwige; Bobowski, Marie et al. · 2011 · BMC Biotechnology · DOI

Full title: Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0

Authors: Teylaert, Béatrice; Meurice, Edwige; Bobowski, Marie; Harduin‐Lepers, Anne; Gaucher, Christine; Fontayne, Alexandre; Jorieux, Sylvie; Delannoy, Philippe

Year: 2011

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-11-1

Paper Fluorescent labeling in semi-solid medium for selection of mammalian cells secreting high-levels of recombinant proteins

Caron, Antoine W.; Nicolas, Claire; Gaillet, Bruno et al. · 2009 · BMC Biotechnology · DOI

Full title: Fluorescent labeling in semi-solid medium for selection of mammalian cells secreting high-levels of recombinant proteins

Authors: Caron, Antoine W.; Nicolas, Claire; Gaillet, Bruno; Ba, Ismaïla; Pinard, Maxime; Garnier, Alain; Massie, Bernard; Gilbert, Rénald

Year: 2009

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-9-42

Paper Generation and characterization of a new mammalian cell line continuously expressing virus-like particles of Japanese encephalitis virus for a subunit vaccine candidate

Hua, Rong-Hong; Li, Yenan; Chen, Zhenshi et al. · 2014 · BMC Biotechnology · DOI

Full title: Generation and characterization of a new mammalian cell line continuously expressing virus-like particles of Japanese encephalitis virus for a subunit vaccine candidate

Authors: Hua, Rong-Hong; Li, Yenan; Chen, Zhenshi; Liu, Like; Huo, Hong; Wang, Xiaolei; Guo, Liping; Shen, Nan; Wang, Jingfei; Bu, Zhigao

Year: 2014

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-14-62

Paper Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

Imai-Nishiya, Harue; Mori, Katsuhiro; Inoue, Miho et al. · 2007 · BMC Biotechnology · DOI

Full title: Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

Authors: Imai-Nishiya, Harue; Mori, Katsuhiro; Inoue, Miho; Wakitani, Masako; Iida, Shigeru; Shitara, Kenya; Satoh, Mitsuo

Year: 2007

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-7-84

Paper Generation of diploid Pichia pastoris strains by mating and their application for recombinant protein production

Chen, Ming‐Tang; Lin, Song; Shandil, Ishaan et al. · 2012 · Microbial Cell Factories · DOI

Full title: Generation of diploid Pichia pastoris strains by mating and their application for recombinant protein production

Authors: Chen, Ming‐Tang; Lin, Song; Shandil, Ishaan; Andrews, Dewan; Stadheim, Terrance A.; Choi, Byung‐Kwon

Year: 2012

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-11-91

Paper Applications of cell sorting in biotechnology

Mattanovich, Diethard; Borth, Nicole · 2006 · Microbial Cell Factories · DOI

Full title: Applications of cell sorting in biotechnology

Authors: Mattanovich, Diethard; Borth, Nicole

Year: 2006

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-5-12

Paper Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies

Chung, Nancy PY; Matthews, Katie; Kim, Helen J. et al. · 2014 · Retrovirology · DOI

Full title: Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies

Authors: Chung, Nancy PY; Matthews, Katie; Kim, Helen J.; Ketas, Thomas J.; Golabek, Michael; Reyes, Kevin de los; Korzun, Jacob; Yasmeen, Anila; Sanders, Rogier W.; Klasse, Per Johan; Wilson, Ian A.; Ward, Andrew B.; Marozsan, Andre J.; Moore, John P.; Cupo, Albert

Year: 2014

Venue: Retrovirology

DOI: https://doi.org/10.1186/1742-4690-11-33

Paper Recombinant protein expression by targeting pre-selected chromosomal loci

Nehlsen, Kristina; Schucht, Roland; Gama-Norton, Leonor et al. · 2009 · BMC Biotechnology · DOI

Full title: Recombinant protein expression by targeting pre-selected chromosomal loci

Authors: Nehlsen, Kristina; Schucht, Roland; Gama-Norton, Leonor; Krömer, W.; Baer, Alexandra; Cayli, Aziz; Häuser, H.; Wirth, Dagmar

Year: 2009

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-9-100

Paper Production and characterization of specific monoclonal antibodies binding the Plasmodium falciparum diagnostic biomarker, histidine-rich protein 2

Leow, Chiuan Yee; Jones, Martina L.; Cheng, Qin et al. · 2014 · Malaria Journal · DOI

Full title: Production and characterization of specific monoclonal antibodies binding the Plasmodium falciparum diagnostic biomarker, histidine-rich protein 2

Authors: Leow, Chiuan Yee; Jones, Martina L.; Cheng, Qin; Mahler, Stephen M.; McCarthy, James

Year: 2014

Venue: Malaria Journal

DOI: https://doi.org/10.1186/1475-2875-13-277

Paper Novel cell engineering of the Unfolded Protein Response to achieve efficient therapeutic protein production cell line

Michael Song; J. Hou; L. Nielsen et al. · 2015 · BMC Proceedings · DOI

Full title: Novel cell engineering of the Unfolded Protein Response to achieve efficient therapeutic protein production cell line

Authors: Michael Song; J. Hou; L. Nielsen; P. Gray

Year: 2015

Venue: BMC Proceedings

DOI: https://doi.org/10.1186/1753-6561-9-s9-p14

Paper Evaluating the expression profile and stability of different UCOE containing vector combinations in mAb-producing CHO cells

Nematpour, Fatemeh Saeid; Mahboudi, Fereidoun; Vaziri, Behrouz et al. · 2017 · BMC Biotechnology · DOI

Full title: Evaluating the expression profile and stability of different UCOE containing vector combinations in mAb-producing CHO cells

Authors: Nematpour, Fatemeh Saeid; Mahboudi, Fereidoun; Vaziri, Behrouz; Khalaj, Vahid; Ahmadi, Samira; Ahmadi, Maryam; Ebadat, Saedeh; Davami, Fatemeh

Year: 2017

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/s12896-017-0330-0

Paper High level transient production of recombinant antibodies and antibody fusion proteins in HEK293 cells

Jäger, Volker; Büssow, Konrad; Wagner, Andreas et al. · 2013 · BMC Biotechnology · DOI

Full title: High level transient production of recombinant antibodies and antibody fusion proteins in HEK293 cells

Authors: Jäger, Volker; Büssow, Konrad; Wagner, Andreas; Weber, Susanne; Hust, Michael; Frenzel, André; Schirrmann, Thomas

Year: 2013

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-13-52

Paper Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell lines

Veith, Nathalie; Ziehr, Holger; MacLeod, Roderick A.F. et al. · 2016 · BMC Biotechnology · DOI

Full title: Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell lines

Authors: Veith, Nathalie; Ziehr, Holger; MacLeod, Roderick A.F.; Reamon-Buettner, Stella Marie

Year: 2016

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/s12896-016-0238-0

Paper Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up

Madhavan, Aravind; Arun, K. B.; Sindhu, Raveendran et al. · 2021 · Microbial Cell Factories · DOI

Full title: Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up

Authors: Madhavan, Aravind; Arun, K. B.; Sindhu, Raveendran; Krishnamoorthy, Jayaram; Reshmy, R.; Sirohi, Ranjna; Pugazhendi, Arivalagan; Awasthi, Mukesh Kumar; Szakács, George; Binod, Parameswaran

Year: 2021

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-021-01617-z

Paper Preclinical development of a novel CD47 nanobody with less toxicity and enhanced anti-cancer therapeutic potential

Ma, Linlin; Zhu, Minmin; Gai, Junwei et al. · 2020 · Journal of Nanobiotechnology · DOI

Full title: Preclinical development of a novel CD47 nanobody with less toxicity and enhanced anti-cancer therapeutic potential

Authors: Ma, Linlin; Zhu, Minmin; Gai, Junwei; Li, Guanghui; Chang, Qing; Peng, Qiao; Cao, Long‐Long; Chen, Wanqing; Zhang, Siyuan; Wan, Yakun

Year: 2020

Venue: Journal of Nanobiotechnology

DOI: https://doi.org/10.1186/s12951-020-0571-2

Paper Screening and selection strategy for the establishment of biosimilar to trastuzumab-expressing CHO-K1 cell lines

Lao, Thailin; Bueno-Soler, Alexi; Durán‐Hernández, Arnelys et al. · 2021 · AMB Express · DOI

Full title: Screening and selection strategy for the establishment of biosimilar to trastuzumab-expressing CHO-K1 cell lines

Authors: Lao, Thailin; Bueno-Soler, Alexi; Durán‐Hernández, Arnelys; Sosa-Aguiar, Katya; Hinojosa-Puerta, Luis Eduardo; Hernández-García, Tays; Luz-Hernández, K.R. de la; Palacios-Oliva, Julio; Boggiano-Ayo, Tammy

Year: 2021

Venue: AMB Express

DOI: https://doi.org/10.1186/s13568-020-01157-6

Paper Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease?

Laustsen, Andreas H.; Johansen, K.; Engmark, Mikael et al. · 2017 · PLoS neglected tropical diseases · DOI

Full title: Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease?

Authors: Laustsen, Andreas H.; Johansen, K.; Engmark, Mikael; Andersen, Mikael Rørdam

Year: 2017

Venue: PLoS neglected tropical diseases

DOI: https://doi.org/10.1371/journal.pntd.0005361

Paper Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G

Miyakawa, Shin; Nomura, Yusuke; Sakamoto, Taiichi et al. · 2008 · RNA · DOI

Full title: Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G

Authors: Miyakawa, Shin; Nomura, Yusuke; Sakamoto, Taiichi; Yamaguchi, Yoshiki; Kato, Koichi; Yamazaki, Satoko; Nakamura, Yoshikazu

Year: 2008

Venue: RNA

DOI: https://doi.org/10.1261/rna.1005808

Paper Intraclonal Protein Expression Heterogeneity in Recombinant CHO Cells

Pilbrough, Warren; Munro, Trent P.; Gray, Peter P. · 2009 · PLoS ONE · DOI

Full title: Intraclonal Protein Expression Heterogeneity in Recombinant CHO Cells

Authors: Pilbrough, Warren; Munro, Trent P.; Gray, Peter P.

Year: 2009

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0008432

Paper SweetBac: A New Approach for the Production of Mammalianised Glycoproteins in Insect Cells

Palmberger, Dieter; Wilson, Iain B. H.; Berger, Imre et al. · 2012 · PLoS ONE · DOI

Full title: SweetBac: A New Approach for the Production of Mammalianised Glycoproteins in Insect Cells

Authors: Palmberger, Dieter; Wilson, Iain B. H.; Berger, Imre; Grabherr, Reingard; Rendić, Dubravko

Year: 2012

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0034226

Paper Efficient Recombinant Production in Mammalian Cells Using a Novel IR/MAR Gene Amplification Method

Araki, Yoshio; Hamafuji, Tetsuro; Noguchi, Chiemi et al. · 2012 · PLoS ONE · DOI

Full title: Efficient Recombinant Production in Mammalian Cells Using a Novel IR/MAR Gene Amplification Method

Authors: Araki, Yoshio; Hamafuji, Tetsuro; Noguchi, Chiemi; Shimizu, Noriaki

Year: 2012

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0041787

Paper Systematic Single-Cell Analysis of Pichia pastoris Reveals Secretory Capacity Limits Productivity

Love, Kerry R.; Politano, Timothy J.; Panagiotou, Vasiliki et al. · 2012 · PLoS ONE · DOI

Full title: Systematic Single-Cell Analysis of Pichia pastoris Reveals Secretory Capacity Limits Productivity

Authors: Love, Kerry R.; Politano, Timothy J.; Panagiotou, Vasiliki; Jiang, Bo; Stadheim, Terrance A.; Love, J. Christopher

Year: 2012

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0037915

Paper Rapid Transient Production in Plants by Replicating and Non-Replicating Vectors Yields High Quality Functional Anti-HIV Antibody

Sainsbury, Frank; Sack, M.; Stadlmann, Johannes et al. · 2010 · PLoS ONE · DOI

Full title: Rapid Transient Production in Plants by Replicating and Non-Replicating Vectors Yields High Quality Functional Anti-HIV Antibody

Authors: Sainsbury, Frank; Sack, M.; Stadlmann, Johannes; Quendler, Heribert; Fischer, Rainer; Lomonossoff, George P.

Year: 2010

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0013976

Paper An Internal Ribosome Entry Site (IRES) Mutant Library for Tuning Expression Level of Multiple Genes in Mammalian Cells

Koh, Esther Y. C.; Ho, Steven C. L.; Mariati et al. · 2013 · PLoS ONE · DOI

Full title: An Internal Ribosome Entry Site (IRES) Mutant Library for Tuning Expression Level of Multiple Genes in Mammalian Cells

Authors: Koh, Esther Y. C.; Ho, Steven C. L.; Mariati; Song, Zhiwei; Bi, Xuezhi; Bardor, Muriel; Yang, Yuansheng

Year: 2013

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0082100

Paper A Multi-Omics Analysis of Recombinant Protein Production in Hek293 Cells

Dietmair, Stefanie; Hodson, Mark P.; Quek, Lake‐Ee et al. · 2012 · PLoS ONE · DOI

Full title: A Multi-Omics Analysis of Recombinant Protein Production in Hek293 Cells

Authors: Dietmair, Stefanie; Hodson, Mark P.; Quek, Lake‐Ee; Timmins, Nicholas; Gray, Peter P.; Nielsen, Lars K.

Year: 2012

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0043394

Paper Fusion of the Dhfr/Mtx and IR/MAR Gene Amplification Methods Produces a Rapid and Efficient Method for Stable Recombinant Protein Production

Noguchi, Chiemi; Araki, Yoshio; Miki, Daisuke et al. · 2012 · PLoS ONE · DOI

Full title: Fusion of the Dhfr/Mtx and IR/MAR Gene Amplification Methods Produces a Rapid and Efficient Method for Stable Recombinant Protein Production

Authors: Noguchi, Chiemi; Araki, Yoshio; Miki, Daisuke; Shimizu, Noriaki

Year: 2012

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0052990

Paper Multiparameter RNA and Codon Optimization: A Standardized Tool to Assess and Enhance Autologous Mammalian Gene Expression

Fath, Stephan; Bauer, Asli; Liss, Michael A. et al. · 2011 · PLoS ONE · DOI

Full title: Multiparameter RNA and Codon Optimization: A Standardized Tool to Assess and Enhance Autologous Mammalian Gene Expression

Authors: Fath, Stephan; Bauer, Asli; Liss, Michael A.; Spriestersbach, Anne; Maertens, Barbara; Hahn, Peter F.; Ludwig, Christine; Schäfer, Frank; Graf, Marcus; Wagner, Ralf

Year: 2011

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0017596

Paper Biochemical Characterization of Human Anti-Hepatitis B Monoclonal Antibody Produced in the Microalgae Phaeodactylum tricornutum

Vanier, Gaëtan; Hempel, Franziska; Chan, Philippe et al. · 2015 · PLoS ONE · DOI

Full title: Biochemical Characterization of Human Anti-Hepatitis B Monoclonal Antibody Produced in the Microalgae Phaeodactylum tricornutum

Authors: Vanier, Gaëtan; Hempel, Franziska; Chan, Philippe; Rodamer, Michael; Vaudry, David; Maier, Uwe G.; Lerouge, Patrice; Bardor, Muriel

Year: 2015

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0139282

Paper Generation of Biologically Active Multi-Sialylated Recombinant Human EPOFc in Plants

Castilho, Alexandra; Neumann, Laura; Gattinger, Pia et al. · 2013 · PLoS ONE · DOI

Full title: Generation of Biologically Active Multi-Sialylated Recombinant Human EPOFc in Plants

Authors: Castilho, Alexandra; Neumann, Laura; Gattinger, Pia; Strasser, Richard; Vorauer‐Uhl, Karola; Sterovsky, Thomas; Altmann, Friedrich; Steinkellner, Herta

Year: 2013

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0054836

Paper Comparison of Internal Ribosome Entry Site (IRES) and Furin-2A (F2A) for Monoclonal Antibody Expression Level and Quality in CHO Cells

Ho, Steven C. L.; Bardor, Muriel; Li, Bin et al. · 2013 · PLoS ONE · DOI

Full title: Comparison of Internal Ribosome Entry Site (IRES) and Furin-2A (F2A) for Monoclonal Antibody Expression Level and Quality in CHO Cells

Authors: Ho, Steven C. L.; Bardor, Muriel; Li, Bin; Lee, Jia Juan; Song, Zhiwei; Tong, Yen Wah; Goh, Lin‐Tang; Yang, Yuansheng

Year: 2013

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0063247

Paper Transgenic Production of an Anti HIV Antibody in the Barley Endosperm

Hensel, Göetz; Floß, Doreen M.; Arcalís, Elsa et al. · 2015 · PLoS ONE · DOI

Full title: Transgenic Production of an Anti HIV Antibody in the Barley Endosperm

Authors: Hensel, Göetz; Floß, Doreen M.; Arcalís, Elsa; Sack, M.; Melnik, Stanislav; Altmann, Friedrich; Rutten, Twan; Kumlehn, Jochen; Stöger, Eva; Conrad, Udo

Year: 2015

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0140476

Paper Optimization of Heavy Chain and Light Chain Signal Peptides for High Level Expression of Therapeutic Antibodies in CHO Cells

Haryadi, Ryan; Ho, Steven C. L.; Kok, Yee Jiun et al. · 2015 · PLoS ONE · DOI

Full title: Optimization of Heavy Chain and Light Chain Signal Peptides for High Level Expression of Therapeutic Antibodies in CHO Cells

Authors: Haryadi, Ryan; Ho, Steven C. L.; Kok, Yee Jiun; Pu, Helen X.; Zheng, Lu; Pereira, Natasha Ann; Li, Bin; Bi, Xuezhi; Goh, Lin-Tang; Yang, Yuansheng; Song, Zhiwei

Year: 2015

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0116878

Paper Analyzing Clonal Variation of Monoclonal Antibody-Producing CHO Cell Lines Using an In Silico Metabolomic Platform

Ghorbaniaghdam, Atefeh; Chen, Jingkui; Henry, Olivier et al. · 2014 · PLoS ONE · DOI

Full title: Analyzing Clonal Variation of Monoclonal Antibody-Producing CHO Cell Lines Using an In Silico Metabolomic Platform

Authors: Ghorbaniaghdam, Atefeh; Chen, Jingkui; Henry, Olivier; Jolicœur, Mario

Year: 2014

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0090832

Paper The Development of a Recombinant scFv Monoclonal Antibody Targeting Canine CD20 for Use in Comparative Medicine

Jain, Saurabh; Aresu, Luca; Comazzi, S. et al. · 2016 · PLoS ONE · DOI

Full title: The Development of a Recombinant scFv Monoclonal Antibody Targeting Canine CD20 for Use in Comparative Medicine

Authors: Jain, Saurabh; Aresu, Luca; Comazzi, S.; Shi, Jianguo; Worrall, Erin G.; Clayton, John; Humphries, W. R.; Hemmington, Sandra; Davis, Paul J.; Murray, Euan; Limeneh, Asmare A.; Ball, Kathryn L.; Růčková, Eva; Müller, Petr; Vojtěšek, Bořivoj; Fåhræus, Robin; Argyle, David J.; Hupp, Ted R.

Year: 2016

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0148366

Paper Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells

Torres, Mauro; Zúñiga, Roberto Ariel Abeldaño; Gutiérrez-González, Matías et al. · 2018 · PLoS ONE · DOI

Full title: Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells

Authors: Torres, Mauro; Zúñiga, Roberto Ariel Abeldaño; Gutiérrez-González, Matías; Vergara, Mauricio; Collazo, Norberto; Reyes, Juan G.; Berríos, Julio; Aguillón, Juan Carlos; Molina, Marı́a Carmen; Altamirano, Claudia

Year: 2018

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0194510

Paper Evaluating the efficiency of CHEF and CMV promoter with IRES and Furin/2A linker sequences for monoclonal antibody expression in CHO cells

Ebadat, Saeedeh; Ahmadi, Samira; Ahmadi, Maryam et al. · 2017 · PLoS ONE · DOI

Full title: Evaluating the efficiency of CHEF and CMV promoter with IRES and Furin/2A linker sequences for monoclonal antibody expression in CHO cells

Authors: Ebadat, Saeedeh; Ahmadi, Samira; Ahmadi, Maryam; Nematpour, Fatemeh Saeid; Barkhordari, Farzaneh; Mahdian, Reza; Davami, Fatemeh; Mahboudi, Fereidoun

Year: 2017

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0185967

Paper Comparison of secretory signal peptides for heterologous protein expression in microalgae: Expanding the secretion portfolio for Chlamydomonas reinhardtii

Molino, João Vitor Dutra; Carvalho, João Carlos Monteiro de; Mayfield, Stephen P. · 2018 · PLoS ONE · DOI

Full title: Comparison of secretory signal peptides for heterologous protein expression in microalgae: Expanding the secretion portfolio for Chlamydomonas reinhardtii

Authors: Molino, João Vitor Dutra; Carvalho, João Carlos Monteiro de; Mayfield, Stephen P.

Year: 2018

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0192433

Paper Metabolic engineering of CHO cells for the development of a robust protein production platform

Gupta, Sanjeev Kumar; Srivastava, S. K.; Sharma, Ankit et al. · 2017 · PLoS ONE · DOI

Full title: Metabolic engineering of CHO cells for the development of a robust protein production platform

Authors: Gupta, Sanjeev Kumar; Srivastava, S. K.; Sharma, Ankit; Nalage, Vaibhav H. H.; Salvi, Darshita; Kushwaha, Hiralal; Chitnis, Nikhil B.; Shukla, Pratyoosh

Year: 2017

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0181455

Paper REAL-Select: Full-Length Antibody Display and Library Screening by Surface Capture on Yeast Cells

Rhiel, Laura; Krah, Simon; Günther, Ralf et al. · 2014 · PLoS ONE · DOI

Full title: REAL-Select: Full-Length Antibody Display and Library Screening by Surface Capture on Yeast Cells

Authors: Rhiel, Laura; Krah, Simon; Günther, Ralf; Becker, Stefan; Kolmar, Harald; Hock, Björn

Year: 2014

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0114887

Paper Monoclonal antibodies expression improvement in CHO cells by PiggyBac transposition regarding vectors ratios and design

Ahmadi, Samira; Davami, Fatemeh; Davoudi, Noushin et al. · 2017 · PLoS ONE · DOI

Full title: Monoclonal antibodies expression improvement in CHO cells by PiggyBac transposition regarding vectors ratios and design

Authors: Ahmadi, Samira; Davami, Fatemeh; Davoudi, Noushin; Nematpour, Fatemeh Saeid; Ahmadi, Maryam; Ebadat, Saeedeh; Azadmanesh, Kayhan; Barkhordari, Farzaneh; Mahboudi, Fereidoun

Year: 2017

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0179902

Paper Chromatin Function Modifying Elements in an Industrial Antibody Production Platform - Comparison of UCOE, MAR, STAR and cHS4 Elements

Saunders, Fay Louise; Sweeney, Berni; Antoniou, Michael et al. · 2015 · PLoS ONE · DOI

Full title: Chromatin Function Modifying Elements in an Industrial Antibody Production Platform - Comparison of UCOE, MAR, STAR and cHS4 Elements

Authors: Saunders, Fay Louise; Sweeney, Berni; Antoniou, Michael; Stephens, Paul E.; Cain, Katharine

Year: 2015

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0120096

Paper Monoclonal antibodies for the prevention of rabies: theory and clinical practice

Nagarajan, Thirumeni; Marissen, Wilfred E.; Rupprecht, Charles E. · 2014 · Antibody Technology Journal · DOI

Full title: Monoclonal antibodies for the prevention of rabies: theory and clinical practice

Authors: Nagarajan, Thirumeni; Marissen, Wilfred E.; Rupprecht, Charles E.

Year: 2014

Venue: Antibody Technology Journal

DOI: https://doi.org/10.2147/anti.s33533

Paper A system for site-specific integration of transgenes in mammalian cells

Chi, Xiuling; Zheng, Qi; Jiang, Ruhong et al. · 2019 · PLoS ONE · DOI

Full title: A system for site-specific integration of transgenes in mammalian cells

Authors: Chi, Xiuling; Zheng, Qi; Jiang, Ruhong; Chen-Tsai, Ruby Yanru; Kong, Ling-Jie

Year: 2019

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0219842

Paper Advances in improving mammalian cells metabolism for recombinant protein production

Altamirano, Claudia; Berríos, Julio; Vergara, Mauricio et al. · 2013 · Electronic Journal of Biotechnology · DOI

Full title: Advances in improving mammalian cells metabolism for recombinant protein production

Authors: Altamirano, Claudia; Berríos, Julio; Vergara, Mauricio; Becerra, Silvana

Year: 2013

Venue: Electronic Journal of Biotechnology

DOI: https://doi.org/10.2225/vol16-issue3-fulltext-2

Paper Factors Affecting the Expression of Recombinant Protein and Improvement Strategies in Chinese Hamster Ovary Cells

Li, Zhengmei; Fan, Zhenlin; Wang, Xiao-Yin et al. · 2022 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Factors Affecting the Expression of Recombinant Protein and Improvement Strategies in Chinese Hamster Ovary Cells

Authors: Li, Zhengmei; Fan, Zhenlin; Wang, Xiao-Yin; Wang, Tianyun

Year: 2022

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2022.880155

Paper Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry

Sumit Kumar Singh; Kelvin H. Lee · 2022 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry

Authors: Sumit Kumar Singh; Kelvin H. Lee

Year: 2022

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2021.805788

Paper Screening Strategies for High-Yield Chinese Hamster Ovary Cell Clones

Yang, Wenwen; Zhang, Junhe; Xiao, Yunxi et al. · 2022 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Screening Strategies for High-Yield Chinese Hamster Ovary Cell Clones

Authors: Yang, Wenwen; Zhang, Junhe; Xiao, Yunxi; Li, Wenqing; Wang, Tianyun

Year: 2022

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2022.858478

Paper Crystallizable Fragment Glycoengineering for Therapeutic Antibodies Development

Li, Wei; Zhu, Zhongyu; Chen, Weizao et al. · 2017 · Frontiers in Immunology · DOI

Full title: Crystallizable Fragment Glycoengineering for Therapeutic Antibodies Development

Authors: Li, Wei; Zhu, Zhongyu; Chen, Weizao; Feng, Yang; Dimitrov, Dimiter S.

Year: 2017

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2017.01554

Paper Engineering protein glycosylation in CHO cells to be highly similar to murine host cells

Gupta, Shivani; Shah, Bhavana; Fung, Coral Shek et al. · 2023 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Engineering protein glycosylation in CHO cells to be highly similar to murine host cells

Authors: Gupta, Shivani; Shah, Bhavana; Fung, Coral Shek; Chan, Pik K.; Wakefield, Devin L.; Kuhns, Scott; Goudar, Chetan T.; Piret, James M.

Year: 2023

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2023.1113994

Paper Strategies and Considerations for Improving Recombinant Antibody Production and Quality in Chinese Hamster Ovary Cells

Zhang, Junhe; Shan, Linlin; Liang, Fan et al. · 2022 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Strategies and Considerations for Improving Recombinant Antibody Production and Quality in Chinese Hamster Ovary Cells

Authors: Zhang, Junhe; Shan, Linlin; Liang, Fan; Du, Chenyang; Li, Jinɡjinɡ

Year: 2022

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2022.856049

Paper Role of Fc Core Fucosylation in the Effector Function of IgG1 Antibodies

Golay, Josée; Andrea, Alain E.; Cattaneo, Irene · 2022 · Frontiers in Immunology · DOI

Full title: Role of Fc Core Fucosylation in the Effector Function of IgG1 Antibodies

Authors: Golay, Josée; Andrea, Alain E.; Cattaneo, Irene

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.929895

Paper Risk-Based Control Strategies of Recombinant Monoclonal Antibody Charge Variants

Beck, Alain; Nowak, Christine; Meshulam, Deborah et al. · 2022 · Antibodies · DOI

Full title: Risk-Based Control Strategies of Recombinant Monoclonal Antibody Charge Variants

Authors: Beck, Alain; Nowak, Christine; Meshulam, Deborah; Reynolds, Kristina; Chen, David; Pacardo, Dennis B.; Nicholls, Samantha B.; Carven, Gregory J.; Gu, Zhenyu; Fang, Jing; Wang, Dongdong; Katiyar, Amit; Tao, Xiang; Liu, Hongcheng

Year: 2022

Venue: Antibodies

DOI: https://doi.org/10.3390/antib11040073

Paper Protein N-glycosylation in eukaryotic microalgae and its impact on the production of nuclear expressed biopharmaceuticals

Mathieu‐Rivet, Elodie; Kiefer‐Meyer, Marie‐Christine; Vanier, Gaëtan et al. · 2014 · Frontiers in Plant Science · DOI

Full title: Protein N-glycosylation in eukaryotic microalgae and its impact on the production of nuclear expressed biopharmaceuticals

Authors: Mathieu‐Rivet, Elodie; Kiefer‐Meyer, Marie‐Christine; Vanier, Gaëtan; Ovide, ClÃ©ment; Burel, Carole; Lerouge, Patrice; Bardor, Muriel

Year: 2014

Venue: Frontiers in Plant Science

DOI: https://doi.org/10.3389/fpls.2014.00359

Paper Sophisticated Cloning, Fermentation, and Purification Technologies for an Enhanced Therapeutic Protein Production: A Review

Gupta, Sanjeev Kumar; Shukla, Pratyoosh · 2017 · Frontiers in Pharmacology · DOI

Full title: Sophisticated Cloning, Fermentation, and Purification Technologies for an Enhanced Therapeutic Protein Production: A Review

Authors: Gupta, Sanjeev Kumar; Shukla, Pratyoosh

Year: 2017

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2017.00419

Paper Development of a Novel Anti-EpCAM Monoclonal Antibody for Various Applications

Guanjie Li; Hiroyuki Suzuki; Teizo Asano et al. · 2022 · Antibodies · DOI

Full title: Development of a Novel Anti-EpCAM Monoclonal Antibody for Various Applications

Authors: Guanjie Li; Hiroyuki Suzuki; Teizo Asano; Tomohiro Tanaka; Hiroyoshi Suzuki; M. Kaneko; Y. Kato

Year: 2022

Venue: Antibodies

DOI: https://doi.org/10.3390/antib11020041

Paper Putting the Spotlight Back on Plant Suspension Cultures

Santos, Rita B.; Abranches, Rita; Fischer, Rainer et al. · 2016 · Frontiers in Plant Science · DOI

Full title: Putting the Spotlight Back on Plant Suspension Cultures

Authors: Santos, Rita B.; Abranches, Rita; Fischer, Rainer; Sack, M.; Holland, Tanja

Year: 2016

Venue: Frontiers in Plant Science

DOI: https://doi.org/10.3389/fpls.2016.00297

Paper NanoLuc Luciferase – A Multifunctional Tool for High Throughput Antibody Screening

Boute, Nicolas; Lowe, Peter; Berger, Sven et al. · 2016 · Frontiers in Pharmacology · DOI

Full title: NanoLuc Luciferase – A Multifunctional Tool for High Throughput Antibody Screening

Authors: Boute, Nicolas; Lowe, Peter; Berger, Sven; Malissard, Martine; Robert, Alain; Tesar, Michael

Year: 2016

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2016.00027

Paper Improved Titer in Late-Stage Mammalian Cell Culture Manufacturing by Re-Cloning.

He, Qin; Rehmann, Matthew S; Tian, Jun et al. · 2022 · Bioengineering (Basel, Switzerland) · DOI

Full title: Improved Titer in Late-Stage Mammalian Cell Culture Manufacturing by Re-Cloning.

Authors: He, Qin; Rehmann, Matthew S; Tian, Jun; Xu, Jianlin; Sabino, Luzmary; Vandermark, Erik; Basson, Ziev; Po, Iris; Bierilo, Kathleen; Tremml, Gabi; Rizzi, Giovanni; Langsdorf, Erik F; Qian, Nan-Xin; Borys, Michael C; Khetan, Anurag; Li, Zheng-Jian

Year: 2022

Venue: Bioengineering (Basel, Switzerland)

DOI: https://doi.org/10.3390/bioengineering9040173

Paper Current Advancements in Addressing Key Challenges of Therapeutic Antibody Design, Manufacture, and Formulation

Sifniotis, Vicki; Cruz, Esteban; Eroglu, Barbaros et al. · 2019 · Antibodies · DOI

Full title: Current Advancements in Addressing Key Challenges of Therapeutic Antibody Design, Manufacture, and Formulation

Authors: Sifniotis, Vicki; Cruz, Esteban; Eroglu, Barbaros; Kayser, Veysel

Year: 2019

Venue: Antibodies

DOI: https://doi.org/10.3390/antib8020036

Paper Affecting HEK293 Cell Growth and Production Performance by Modifying the Expression of Specific Genes

Abaandou, Laura; Quan, David N.; Shiloach, Joseph · 2021 · Cells · DOI

Full title: Affecting HEK293 Cell Growth and Production Performance by Modifying the Expression of Specific Genes

Authors: Abaandou, Laura; Quan, David N.; Shiloach, Joseph

Year: 2021

Venue: Cells

DOI: https://doi.org/10.3390/cells10071667

Paper Industrial Production of Proteins with Pichia pastoris—Komagataella phaffii

Barone, Giovanni Davide; Emmerstorfer‐Augustin, Anita; Biundo, Antonino et al. · 2023 · Biomolecules · DOI

Full title: Industrial Production of Proteins with Pichia pastoris—Komagataella phaffii

Authors: Barone, Giovanni Davide; Emmerstorfer‐Augustin, Anita; Biundo, Antonino; Pisano, Isabella; Coccetti, Paola; Mapelli, Valeria; Camattari, Andrea

Year: 2023

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom13030441

Paper Function and 3D Structure of the N-Glycans on Glycoproteins

Nagae, Masamichi; Yamaguchi, Yoshiki · 2012 · International Journal of Molecular Sciences · DOI

Full title: Function and 3D Structure of the N-Glycans on Glycoproteins

Authors: Nagae, Masamichi; Yamaguchi, Yoshiki

Year: 2012

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms13078398

Paper Trends in Upstream and Downstream Process Development for Antibody Manufacturing

Gronemeyer, Petra; Ditz, Reinhard; Strube, Jochen · 2014 · Bioengineering · DOI

Full title: Trends in Upstream and Downstream Process Development for Antibody Manufacturing

Authors: Gronemeyer, Petra; Ditz, Reinhard; Strube, Jochen

Year: 2014

Venue: Bioengineering

DOI: https://doi.org/10.3390/bioengineering1040188

Paper A Bench-Top Approach for Isolation of Single Antibody Producing Chinese Hamster Ovary (CHO) Cells Using a Microwell-Based Microfluidic Device.

Fuadiyah, Salma; Chotchindakun, Kittipat; Phatthanakun, Rungrueang et al. · 2022 · Micromachines · DOI

Full title: A Bench-Top Approach for Isolation of Single Antibody Producing Chinese Hamster Ovary (CHO) Cells Using a Microwell-Based Microfluidic Device.

Authors: Fuadiyah, Salma; Chotchindakun, Kittipat; Phatthanakun, Rungrueang; Kuntanawat, Panwong; Yamabhai, Montarop

Year: 2022

Venue: Micromachines

DOI: https://doi.org/10.3390/mi13111939

Paper A Simple Method to Reduce both Lactic Acid and Ammonium Production in Industrial Animal Cell Culture

Freund, N; Croughan, Matthew S. · 2018 · International Journal of Molecular Sciences · DOI

Full title: A Simple Method to Reduce both Lactic Acid and Ammonium Production in Industrial Animal Cell Culture

Authors: Freund, N; Croughan, Matthew S.

Year: 2018

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms19020385

Paper Advances in Mammalian Cell Line Development Technologies for Recombinant Protein Production

Lai, Tingfeng; Yang, Yuansheng; Ng, Say Kong · 2013 · Pharmaceuticals · DOI

Full title: Advances in Mammalian Cell Line Development Technologies for Recombinant Protein Production

Authors: Lai, Tingfeng; Yang, Yuansheng; Ng, Say Kong

Year: 2013

Venue: Pharmaceuticals

DOI: https://doi.org/10.3390/ph6050579

Paper CRISPR Technologies in Chinese Hamster Ovary Cell Line Engineering

Glinšek, Katja; Bozovičar, Krištof; Bratkovič, Tomaž · 2023 · International Journal of Molecular Sciences · DOI

Full title: CRISPR Technologies in Chinese Hamster Ovary Cell Line Engineering

Authors: Glinšek, Katja; Bozovičar, Krištof; Bratkovič, Tomaž

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms24098144

Paper Photopolymer Flexographic Printing Plate Mold for PDMS Microfluidic Manufacture

Ana Belén Peñaherrera‐Pazmiño; Gustavo Rosero; Maximiliano S. Perez et al. · 2025 · Polymers · DOI

Full title: Photopolymer Flexographic Printing Plate Mold for PDMS Microfluidic Manufacture

Authors: Ana Belén Peñaherrera‐Pazmiño; Gustavo Rosero; Maximiliano S. Perez; B. Lerner

Year: 2025

Venue: Polymers

DOI: https://doi.org/10.3390/polym17131723

Paper Identification of Cystatin SN as a novel tumor marker for colorectal cancer.

K. Yoneda; Hiroshi Iida; Hiroki Endo et al. · 2009 · International Journal of Oncology · DOI

Full title: Identification of Cystatin SN as a novel tumor marker for colorectal cancer.

Authors: K. Yoneda; Hiroshi Iida; Hiroki Endo; K. Hosono; Tomoyuki Akiyama; Hirokazu Takahashi; M. Inamori; Y. Abe; M. Yoneda; K. Fujita; S. Kato; Y. Nozaki; Y. Ichikawa; H. Uozaki; M. Fukayama; T. Shimamura; T. Kodama; H. Aburatani; Chihiro Miyazawa; Keisuke Ishii; N. Hosomi; M. Sagara; Masazumi Takahashi; H. Ike; H. Saito; Akihiko Kusakabe; A. Nakajima

Year: 2009

Venue: International Journal of Oncology

DOI: https://doi.org/10.3892/ijo_00000310

Paper Monoclonal antibodies to human interferon‐gamma: production, affinity purification and radioimmunoassay.

D. Novick; Zelig Eshhar; D. Fischer et al. · 1983 · EMBO Journal · DOI

Full title: Monoclonal antibodies to human interferon‐gamma: production, affinity purification and radioimmunoassay.

Authors: D. Novick; Zelig Eshhar; D. Fischer; J. Friedlander; Menachem Rubinstein

Year: 1983

Venue: EMBO Journal

DOI: https://doi.org/10.1002/j.1460-2075.1983.tb01618.x

Paper Amino acids in the cultivation of mammalian cells

Salazar, Andrew; Keusgen, Michael; Hagen, Jörg von · 2016 · Amino Acids · DOI

Full title: Amino acids in the cultivation of mammalian cells

Authors: Salazar, Andrew; Keusgen, Michael; Hagen, Jörg von

Year: 2016

Venue: Amino Acids

DOI: https://doi.org/10.1007/s00726-016-2181-8

Paper Effects of process intensification on homogeneity of an IgG1:κ monoclonal antibody during perfusion culture

Liang, George H.; Madhavarao, Chikkathur N.; Morris, Caitlin et al. · 2024 · Applied Microbiology and Biotechnology · DOI

Full title: Effects of process intensification on homogeneity of an IgG1:κ monoclonal antibody during perfusion culture

Authors: Liang, George H.; Madhavarao, Chikkathur N.; Morris, Caitlin; O'Connor, T; Ashraf, Muhammad; Yoon, Seongkyu

Year: 2024

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-024-13110-9

Paper Transposon vector-mediated stable gene transfer for the accelerated establishment of recombinant mammalian cell pools allowing for high-yield production of biologics

Natalie Tschorn; K. Berg; J. Stitz · 2020 · Biotechnology Letters · DOI

Full title: Transposon vector-mediated stable gene transfer for the accelerated establishment of recombinant mammalian cell pools allowing for high-yield production of biologics

Authors: Natalie Tschorn; K. Berg; J. Stitz

Year: 2020

Venue: Biotechnology Letters

DOI: https://doi.org/10.1007/s10529-020-02889-y

Paper The role of Raman spectroscopy in biopharmaceuticals from development to manufacturing

Esmonde‐White, Karen A.; Cuellar, Maryann; Lewis, Ian R. · 2021 · Analytical and Bioanalytical Chemistry · DOI

Full title: The role of Raman spectroscopy in biopharmaceuticals from development to manufacturing

Authors: Esmonde‐White, Karen A.; Cuellar, Maryann; Lewis, Ian R.

Year: 2021

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-021-03727-4

Paper Recombinant therapeutic proteins degradation and overcoming strategies in CHO cells

Geng, Shao‐Lei; Zhao, Xiaojie; Zhang, Xi et al. · 2024 · Applied Microbiology and Biotechnology · DOI

Full title: Recombinant therapeutic proteins degradation and overcoming strategies in CHO cells

Authors: Geng, Shao‐Lei; Zhao, Xiaojie; Zhang, Xi; Zhang, Jihong; Mi, Chunliu; Wang, Tianyun

Year: 2024

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-024-13008-6

Paper Albumin and mammalian cell culture: implications for biotechnology applications

Francis, Geoffrey L. · 2010 · Cytotechnology · DOI

Full title: Albumin and mammalian cell culture: implications for biotechnology applications

Authors: Francis, Geoffrey L.

Year: 2010

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-010-9263-3

Paper Developing the Totality of Evidence for Biosimilars: Regulatory Considerations and Building Confidence for the Healthcare Community

Márkus, Richárd; Liu, Jennifer; Ramchandani, Monica et al. · 2017 · BioDrugs · DOI

Full title: Developing the Totality of Evidence for Biosimilars: Regulatory Considerations and Building Confidence for the Healthcare Community

Authors: Márkus, Richárd; Liu, Jennifer; Ramchandani, Monica; Landa, Diana; Born, Teresa L.; Kaur, Primal

Year: 2017

Venue: BioDrugs

DOI: https://doi.org/10.1007/s40259-017-0218-5

Paper Single-Batch Production of Recombinant Human Polyclonal Antibodies

Nielsen, Lars S.; Baer, Alexandra; Müller, Christian et al. · 2010 · Molecular Biotechnology · DOI

Full title: Single-Batch Production of Recombinant Human Polyclonal Antibodies

Authors: Nielsen, Lars S.; Baer, Alexandra; Müller, Christian; Gregersen, Kristian; Mønster, Nina T.; Rasmussen, Søren K.; Weilguny, Dietmar; Tolstrup, Anne B.

Year: 2010

Venue: Molecular Biotechnology

DOI: https://doi.org/10.1007/s12033-010-9270-9

Paper Physicochemical and Functional Comparability Between the Proposed Biosimilar Rituximab GP2013 and Originator Rituximab

Visser, Jan Marinus; Feuerstein, Isabel; Stangler, Thomas et al. · 2013 · BioDrugs · DOI

Full title: Physicochemical and Functional Comparability Between the Proposed Biosimilar Rituximab GP2013 and Originator Rituximab

Authors: Visser, Jan Marinus; Feuerstein, Isabel; Stangler, Thomas; Schmiederer, Timo; Fritsch, Cornelius; Schiestl, Martin

Year: 2013

Venue: BioDrugs

DOI: https://doi.org/10.1007/s40259-013-0036-3

Paper The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

Xu, Xun; Nagarajan, Harish; Lewis, Nathan E. et al. · 2011 · Nature Biotechnology · DOI

Full title: The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

Authors: Xu, Xun; Nagarajan, Harish; Lewis, Nathan E.; Pan, Shengkai; Cai, Zhiming; Liu, Xin; Chen, Wenbin; Xie, Min; Wang, Wenliang; Hammond, Stephanie; Andersen, Mikael Rørdam; Neff, Norma; Passarelli, Benedetto; Koh, Winston; Fan, H. Christina; Wang, Jianbin; Gui, Yaoting; Lee, Kelvin H.; Betenbaugh, Michael J.; Quake, Stephen R.; Famili, Iman; Palsson, Bernhard Ø.; Wang, Jun

Year: 2011

Venue: Nature Biotechnology

DOI: https://doi.org/10.1038/nbt.1932

Paper A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency

Chodorge, Matthieu; Züger, Sara; Stirnimann, Christian U. et al. · 2012 · Cell Death and Differentiation · DOI

Full title: A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency

Authors: Chodorge, Matthieu; Züger, Sara; Stirnimann, Christian U.; Briand, Christophe; Jermutus, Lutz; Grütter, Markus G.; Minter, Ralph

Year: 2012

Venue: Cell Death and Differentiation

DOI: https://doi.org/10.1038/cdd.2011.208

Paper MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP

Yan, Yahui; Rato, Cláudia; Rohland, Lukas et al. · 2019 · Nature Communications · DOI

Full title: MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP

Authors: Yan, Yahui; Rato, Cláudia; Rohland, Lukas; Preißler, Steffen; Ron, David

Year: 2019

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-019-08450-4

Paper The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells

Tian, Weihua; Ye, Zilu; Wang, Shengjun et al. · 2019 · Nature Communications · DOI

Full title: The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells

Authors: Tian, Weihua; Ye, Zilu; Wang, Shengjun; Schulz, Morten Alder; Coillie, Julie Van; Sun, Lingbo; Chen, Yen‐Hsi; Narimatsu, Yoshiki; Hansen, Lars Hestbjerg; Kristensen, Claus; Mandel, Ulla; Bennett, Eric; Jabbarzadeh‐Tabrizi, Siamak; Schiffmann, Raphael; Shen, Jin‐Song; Vakhrushev, Sergey Y.; Clausen, Henrik; Yang, Zhang

Year: 2019

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-019-09809-3

Paper S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

Liang, Joshua G.; Su, Danmei; Song, Tian‐Zhang et al. · 2021 · Nature Communications · DOI

Full title: S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

Authors: Liang, Joshua G.; Su, Danmei; Song, Tian‐Zhang; Zeng, Yilan; Huang, Weijin; Wu, Jinhua; Xu, Rong; Luo, Peiwen; Yang, Xiaofang; Zhang, Xiaodong; Luo, Shuangru; Liang, Ying; Li, Xinglin; Huang, Jiaju; Wang, Qiang; Huang, Xueqin; Xu, Qingsong; Luo, Mei; Huang, Anliang; Luo, Dongxia; Zhao, Chenyan; Yang, Fan; Han, Jian-Bao; Zheng, Yong‐Tang; Liang, Peng

Year: 2021

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-021-21634-1

Paper Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG

Fischer, Nicolas; Elson, Greg; Magistrelli, Giovanni et al. · 2015 · Nature Communications · DOI

Full title: Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG

Authors: Fischer, Nicolas; Elson, Greg; Magistrelli, Giovanni; Dheilly, Elie; Fouque, Nicolas; Laurendon, Amélie; Gueneau, Franck; Ravn, Ulla; Depoisier, Jean-François; Moine, Valéry; Raimondi, Sylvain; Malinge, Pauline; Grazia, Laura Di; Rousseau, François; Poitevin, Yves; Calloud, Sébastien; Cayatte, Pierre-Alexis; Alcoz, Mathias; Pontini, Guillemette; Fagète, Séverine; Broyer, Lucile; Corbier, Marie; Schrag, Delphine; Didelot, Gérard; Bosson, Nicolas; Costes, Nicolas; Cons, Laura; Buatois, Vanessa; Johnson, Zoë; Ferlin, Walter; Masternak, Krzysztof; Kosco‐Vilbois, Marie

Year: 2015

Venue: Nature Communications

DOI: https://doi.org/10.1038/ncomms7113

Paper Multiplex secretome engineering enhances recombinant protein production and purity

Kol, Stefan; Ley, Daniel; Wulff, Tune et al. · 2020 · Nature Communications · DOI

Full title: Multiplex secretome engineering enhances recombinant protein production and purity

Authors: Kol, Stefan; Ley, Daniel; Wulff, Tune; Decker, Marianne; Arnsdorf, Johnny; Schoffelen, Sanne; Hansen, Anders Holmgaard; Jensen, Tanja Lyholm; Gutierrez, Jahir M.; Chiang, Austin W.T.; Masson, Helen O.; Palsson, Bernhard Ø.; Voldborg, Björn G.; Pedersen, Lasse Ebdrup; Kildegaard, Helene Faustrup; Lee, Gyun Min; Lewis, Nathan E.

Year: 2020

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-020-15866-w

Paper Developing therapeutic monoclonal antibodies at pandemic pace

Kelley, Brian D. · 2020 · Nature Biotechnology · DOI

Full title: Developing therapeutic monoclonal antibodies at pandemic pace

Authors: Kelley, Brian D.

Year: 2020

Venue: Nature Biotechnology

DOI: https://doi.org/10.1038/s41587-020-0512-5

Paper Single-cell sorting based on secreted products for functionally defined cell therapies

Miwa, Hiromi; Dimatteo, Robert; Rutte, Joseph de et al. · 2022 · Microsystems & Nanoengineering · DOI

Full title: Single-cell sorting based on secreted products for functionally defined cell therapies

Authors: Miwa, Hiromi; Dimatteo, Robert; Rutte, Joseph de; Ghosh, Rajesh; Carlo, Dino Di

Year: 2022

Venue: Microsystems & Nanoengineering

DOI: https://doi.org/10.1038/s41378-022-00422-x

Paper Protein design and variant prediction using autoregressive generative models

Shin, Jung-Eun; Riesselman, Adam J.; Kollasch, Aaron W. et al. · 2021 · Nature Communications · DOI

Full title: Protein design and variant prediction using autoregressive generative models

Authors: Shin, Jung-Eun; Riesselman, Adam J.; Kollasch, Aaron W.; McMahon, Conor; Simon, Elana P.; Sander, Chris; Manglik, Aashish; Kruse, Andrew C.; Marks, Debora S.

Year: 2021

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-021-22732-w

Paper A human expression system based on HEK293 for the stable production of recombinant erythropoietin

Chin, Christine Lin; Goh, Justin B.; Srinivasan, Harini et al. · 2019 · Scientific Reports · DOI

Full title: A human expression system based on HEK293 for the stable production of recombinant erythropoietin

Authors: Chin, Christine Lin; Goh, Justin B.; Srinivasan, Harini; Liu, Kaiwen Ivy; Ali, Gowher; Shanmugam, Raghuvaran; Lim, Hsueh Lee; Choo, Matthew S.; Tang, Wen Qin; Tan, Andy Hee‐Meng; Nguyen‐Khuong, Terry; Tan, Meng How; Ng, Say Kong

Year: 2019

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-019-53391-z

Paper High-yield production of “difficult-to-express” proteins in a continuous exchange cell-free system based on CHO cell lysates

Thoring, Lena; Dondapati, Srujan Kumar; Stech, Marlitt et al. · 2017 · Scientific Reports · DOI

Full title: High-yield production of “difficult-to-express” proteins in a continuous exchange cell-free system based on CHO cell lysates

Authors: Thoring, Lena; Dondapati, Srujan Kumar; Stech, Marlitt; Wüstenhagen, Doreen A.; Kubick, Stefan

Year: 2017

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-017-12188-8

Paper Next generation of anti-PD-L1 Atezolizumab with enhanced anti-tumor efficacy in vivo

Li, Maohua; Zhao, Rongqing; Chen, Jianxin et al. · 2021 · Scientific Reports · DOI

Full title: Next generation of anti-PD-L1 Atezolizumab with enhanced anti-tumor efficacy in vivo

Authors: Li, Maohua; Zhao, Rongqing; Chen, Jianxin; Tian, Wenzhi; Xia, Chenxi; Liu, Xudong; Li, Yingzi; Li, Song; Sun, Hunter; Shen, Tong; Ren, Wenlin; Sun, Le

Year: 2021

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-021-85329-9

Paper Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

Noh, Soo Min; Shin, Seunghyeon; Lee, Gyun Min · 2018 · Scientific Reports · DOI

Full title: Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

Authors: Noh, Soo Min; Shin, Seunghyeon; Lee, Gyun Min

Year: 2018

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-018-23720-9

Paper Selection and characterization of DNA aptamer against glucagon receptor by cell-SELEX

Wang, Guodong; Liu, Jun; Chen, Ke et al. · 2017 · Scientific Reports · DOI

Full title: Selection and characterization of DNA aptamer against glucagon receptor by cell-SELEX

Authors: Wang, Guodong; Liu, Jun; Chen, Ke; Xu, Yiling; Liu, Bo; Liao, Jie; Zhu, Lei; Hu, Xiaoxiao; Li, Jianglin; Pu, Ying; Zhong, Wen; Fu, Ting; Liu, Huixia; Tan, Weihong

Year: 2017

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-017-05840-w

Paper Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system

S. Murakami; R. Matsumoto; T. Kanamori · 2019 · Scientific Reports · DOI

Full title: Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system

Authors: S. Murakami; R. Matsumoto; T. Kanamori

Year: 2019

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-018-36691-8

Paper Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

H. Hansen; Claes Nymand Nilsson; A. Lund et al. · 2015 · Scientific Reports · DOI

Full title: Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Authors: H. Hansen; Claes Nymand Nilsson; A. Lund; S. Kol; L. M. Grav; Magnus Lundqvist; Johan Rockberg; G. Lee; M. Andersen; H. F. Kildegaard

Year: 2015

Venue: Scientific Reports

DOI: https://doi.org/10.1038/srep18016

Paper Identification of a monoclonal antibody that targets PD-1 in a manner requiring PD-1 Asn58 glycosylation

Wang, Mingzhu; Wang, Junchao; Wang, Rongjuan et al. · 2019 · Communications Biology · DOI

Full title: Identification of a monoclonal antibody that targets PD-1 in a manner requiring PD-1 Asn58 glycosylation

Authors: Wang, Mingzhu; Wang, Junchao; Wang, Rongjuan; Jiao, Shasha; Wang, Shuang; Zhang, Jinchao; Zhang, Min

Year: 2019

Venue: Communications Biology

DOI: https://doi.org/10.1038/s42003-019-0642-9

Paper Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR

Panousis, Con; Rayzman, Veronika; Johns, Terrance G. et al. · 2005 · British Journal of Cancer · DOI

Full title: Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR

Authors: Panousis, Con; Rayzman, Veronika; Johns, Terrance G.; Renner, Christoph; Liu, Zhong; Cartwright, Gary A.; Lee, F-T; Wang, D; Gan, Hui; Cao, Di; Kypridis, A; Smyth, Fiona E.; Brechbiel, Martin W.; Burgess, Antony W.; Old, Lloyd J.; Scott, Andrew M.

Year: 2005

Venue: British Journal of Cancer

DOI: https://doi.org/10.1038/sj.bjc.6602470

Paper The ENGases: versatile biocatalysts for the production of homogeneous N-linked glycopeptides and glycoproteins

Fairbanks, Antony J. · 2017 · Chemical Society Reviews · DOI

Full title: The ENGases: versatile biocatalysts for the production of homogeneous N-linked glycopeptides and glycoproteins

Authors: Fairbanks, Antony J.

Year: 2017

Venue: Chemical Society Reviews

DOI: https://doi.org/10.1039/c6cs00897f

Paper CMV promoter mutants with a reduced propensity to productivity loss in CHO cells

Moritz, Benjamin; Becker, Peter B.; Göpfert, Ulrich · 2015 · Scientific Reports · DOI

Full title: CMV promoter mutants with a reduced propensity to productivity loss in CHO cells

Authors: Moritz, Benjamin; Becker, Peter B.; Göpfert, Ulrich

Year: 2015

Venue: Scientific Reports

DOI: https://doi.org/10.1038/srep16952

Paper Impact of Different Promoters on Episomal Vectors Harbouring Characteristic Motifs of Matrix Attachment Regions

Wang, Xiao-Yin; Zhang, Jun‐He; Zhang, Xi et al. · 2016 · Scientific Reports · DOI

Full title: Impact of Different Promoters on Episomal Vectors Harbouring Characteristic Motifs of Matrix Attachment Regions

Authors: Wang, Xiao-Yin; Zhang, Jun‐He; Zhang, Xi; Sun, Qiu‐li; Zhao, Chun-Peng; Wang, Tianyun

Year: 2016

Venue: Scientific Reports

DOI: https://doi.org/10.1038/srep26446

Paper Matrix attachment region combinations increase transgene expression in transfected Chinese hamster ovary cells

Zhao, Chun‐Peng; Guo, Xiao; Chen, Si‐Jia et al. · 2017 · Scientific Reports · DOI

Full title: Matrix attachment region combinations increase transgene expression in transfected Chinese hamster ovary cells

Authors: Zhao, Chun‐Peng; Guo, Xiao; Chen, Si‐Jia; Li, Changzheng; Yang, Yun; Zhang, Junhe; Chen, Shao-nan; Jia, Yan‐Long; Wang, Tianyun

Year: 2017

Venue: Scientific Reports

DOI: https://doi.org/10.1038/srep42805

Paper Analytical Characterization of Monoclonal Antibodies with Novel Fc Receptor-Based Chromatography Technique

A. Chakrabarti; J. Kervinen; E. Müller et al. · 2020 · Monoclonal Antibodies [Working Title] · DOI

Full title: Analytical Characterization of Monoclonal Antibodies with Novel Fc Receptor-Based Chromatography Technique

Authors: A. Chakrabarti; J. Kervinen; E. Müller; Toru Tanaka; Kazuaki Muranaka

Year: 2020

Venue: Monoclonal Antibodies [Working Title]

DOI: https://doi.org/10.5772/intechopen.95356

Paper The impact of cell culture on medicine

Ying Chun Lu; Taohsueh Liao · 2024 · ASEAN Journal of Psychiatry · DOI

Full title: The impact of cell culture on medicine

Authors: Ying Chun Lu; Taohsueh Liao

Year: 2024

Venue: ASEAN Journal of Psychiatry

DOI: https://doi.org/10.54615/2231-7805.20169

Paper Strategies for Glycoengineering Therapeutic Proteins

Dammen‐Brower, Kris; Epler, Paige; Zhu, Stanley et al. · 2022 · Frontiers in Chemistry · DOI

Full title: Strategies for Glycoengineering Therapeutic Proteins

Authors: Dammen‐Brower, Kris; Epler, Paige; Zhu, Stanley; Bernstein, Zachary J.; Stabach, Paul R.; Braddock, Demetrios T.; Spangler, Jamie B.; Yarema, Kevin J.

Year: 2022

Venue: Frontiers in Chemistry

DOI: https://doi.org/10.3389/fchem.2022.863118

Paper Recent Developments in Bioprocessing of Recombinant Proteins: Expression Hosts and Process Development

Tripathi, Nagesh K.; Shrivastava, Ambuj · 2019 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Recent Developments in Bioprocessing of Recombinant Proteins: Expression Hosts and Process Development

Authors: Tripathi, Nagesh K.; Shrivastava, Ambuj

Year: 2019

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2019.00420

Paper Expression of Recombinant Antibodies

Frenzel, André; Hust, Michael; Schirrmann, Thomas · 2013 · Frontiers in Immunology · DOI

Full title: Expression of Recombinant Antibodies

Authors: Frenzel, André; Hust, Michael; Schirrmann, Thomas

Year: 2013

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2013.00217

Paper Improving Immunotherapy Through Glycodesign

Buettner, Matthew J.; Shah, Sagar; Saeui, Christopher T. et al. · 2018 · Frontiers in Immunology · DOI

Full title: Improving Immunotherapy Through Glycodesign

Authors: Buettner, Matthew J.; Shah, Sagar; Saeui, Christopher T.; Ariss, Ryan; Yarema, Kevin J.

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.02485

Thesis Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing

Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP] et al. · 2019 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing

Authors: Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP]; Deffune, Elenice; Suazo, Cláudio Alberto Torres

Year: 2019

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1590/0104-6632.20180352s20160463

Thesis Model comparison to describe BHK-21 cell growth and metabolism in stirred tank bioreactors operated in batch mode

Fernández Núñez, Eutimio Gustavo · 2018 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Model comparison to describe BHK-21 cell growth and metabolism in stirred tank bioreactors operated in batch mode

Authors: Fernández Núñez, Eutimio Gustavo

Year: 2018

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.1590/0104-6632.20180352s20160592

Thesis NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods

De Leoz, Maria Lorna A; Duewer, David L; Fung, Adam et al. · 2020 · Utrecht University · DOI

Full title: NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods

Authors: De Leoz, Maria Lorna A; Duewer, David L; Fung, Adam; Liu, Lily; Yau, Hoi Kei; Potter, Oscar; Staples, Gregory O; Furuki, Kenichiro; Frenkel, Ruth; Hu, Yunli; Sosic, Zoran; Zhang, Peiqing; Altmann, Friedrich; Gru Nwald-Grube, Clemens; Shao, Chun; Zaia, Joseph; Evers, Waltraud; Pengelley, Stuart; Suckau, Detlev; Wiechmann, Anja; Resemann, Anja; Jabs, Wolfgang; Beck, Alain; Froehlich, John W; Huang, Chuncui; Li, Yan; Liu, Yaming; Sun, Shiwei; Wang, Yaojun; Seo, Youngsuk; An, Hyun Joo; Reichardt, Niels-Christian; Ruiz, Juan Echevarria; Archer-Hartmann, Stephanie; Azadi, Parastoo; Bell, Len; Lakos, Zsuzsanna; An, Yanming; Cipollo, John F; Pucic-Bakovic, Maja; Štambuk, Jerko; Lauc, Gordan; Li, Xu; Wang, Peng George; Bock, Andreas; Yang, Shuang; Lee, Ju Yeon; Heck, Albert J R; Yang, Yang; Haselberg, Rob

Year: 2020

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/394141

Thesis Automated pipeline for rapid production and screening of HIV-specific monoclonal antibodies using pichia pastoris

Shah, Kartik A; Clark, John J; Goods, Brittany A. et al. · 2017 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Automated pipeline for rapid production and screening of HIV-specific monoclonal antibodies using pichia pastoris

Authors: Shah, Kartik A; Clark, John J; Goods, Brittany A.; Politano, Timothy James; Mozdzierz, Nicholas Joseph; Zimnisky, Ross; Leeson, Rachel; Love, John C; Love, Kerry R.

Year: 2017

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/109438

Thesis Effect of adenosine and cordycepin on recombinant antibody production yields in two different Chinease hamster ovary cell lines

Jarusintanakorn, Salinthip; Rangnoi, Kuntalee; Yamabhai, Montarop et al. · 2024 · Utrecht University · DOI

Full title: Effect of adenosine and cordycepin on recombinant antibody production yields in two different Chinease hamster ovary cell lines

Authors: Jarusintanakorn, Salinthip; Rangnoi, Kuntalee; Yamabhai, Montarop; Mastrobattista, Enrico

Year: 2024

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/438035

Thesis Microfluidic Cell Retention Device for Perfusion of Mammalian Suspension Culture

Prentice, Holly; Warkiani, Majid Ebrahimi; Kwon, Taehong et al. · 2017 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Microfluidic Cell Retention Device for Perfusion of Mammalian Suspension Culture

Authors: Prentice, Holly; Warkiani, Majid Ebrahimi; Kwon, Taehong; De Oliveira, Jonas; Madziva, Nyasha; Hamel, Jean-Francois P; Han, Jongyoon

Year: 2017

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/112686

Thesis Small-molecule control of antibody N-glycosylation in engineered mammalian cells

Chang, Michelle; Gaidukov, Leonid; Jung, Giyoung et al. · 2020 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Small-molecule control of antibody N-glycosylation in engineered mammalian cells

Authors: Chang, Michelle; Gaidukov, Leonid; Jung, Giyoung; Tseng, Wen Allen; Scarcelli, John J.; Cornell, Richard; Marshall, Jeffrey K.; Lyles, Jonathan L; Sakorafas, Paul; Chu, An-Hsiang Adam; Cote, Kaffa; Tzvetkova, Boriana; Dolatshahi, Sepideh; Sumit, Madhuresh; Mulukutla, Bhanu Chandra; Lauffenburger, Douglas A; Figueroa, Bruno; Summers, Nevin M; Lu, Timothy K; Weiss, Ron

Year: 2020

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/125977

Thesis Investigating the influence of physiologically relevant hydrostatic pressure on CHO cell batch culture

Shang, Menglin; Kwon, Taehong; Hamel, Jean-Francois P et al. · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Investigating the influence of physiologically relevant hydrostatic pressure on CHO cell batch culture

Authors: Shang, Menglin; Kwon, Taehong; Hamel, Jean-Francois P; Lim, Chwee Teck; Khoo, Bee Luan; Han, Jongyoon

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/143608

Thesis Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe et al. · 2016 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

Authors: López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe; Carrillo-Cocom, Leydi Maribel; Rocha-Pizaña, María del Refugio; Alvarez, Mario Moises

Year: 2016

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/105504

Thesis Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

Sumit, Madhuresh; Dolatshahi, Sepideh; Chu, An-Hsiang Adam et al. · 2020 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

Authors: Sumit, Madhuresh; Dolatshahi, Sepideh; Chu, An-Hsiang Adam; Cote, Kaffa; Scarcelli, John J.; Marshall, Jeffrey K.; Cornell, Richard J.; Weiss, Ron; Lauffenburger, Douglas A.; Mulukutla, Bhanu Chandra; Figueroa, Bruno

Year: 2020

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/125974

Thesis A multi-landing pad DNA integration platform for mammalian cell engineering

Wroblewska, Liliana; Nelson, Tom; Zhang, Xin et al. · 2018 · Massachusetts Institute of Technology (MIT) · DOI

Full title: A multi-landing pad DNA integration platform for mammalian cell engineering

Authors: Wroblewska, Liliana; Nelson, Tom; Zhang, Xin; Liu, Yan; Lowe, Alexis; Bandara, Kalpanie; Baijuraj, Swetha; Zhang, Lin; Gaydukov, Leonid A.; Teague, Brian Paul; Jagtap, Kalpana P; Mamo, Selamawit W; Tseng, Wen Allen; Das, Jishnu; Summers, Nevin M; Lu, Timothy K; Weiss, Ron

Year: 2018

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/115278

Thesis Preemptive variation reduction in biologic drug substance manufacturing

Güereca Valdivia, Ismael · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Preemptive variation reduction in biologic drug substance manufacturing

Authors: Güereca Valdivia, Ismael

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/155982

Thesis Industry 4.0 in Biomanufacturing: Predictive Real-Time Models Using Process Analytical Technology

Murr, Michaela · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Industry 4.0 in Biomanufacturing: Predictive Real-Time Models Using Process Analytical Technology

Authors: Murr, Michaela

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/151710

Thesis Continuous Online Protein Quality Monitoring during Perfusion Culture Production Using an Integrated Micro/Nanofluidic System

Kwon, Taehong; Ko, Sung Hee; Hamel, Jean-Francois P et al. · 2020 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Continuous Online Protein Quality Monitoring during Perfusion Culture Production Using an Integrated Micro/Nanofluidic System

Authors: Kwon, Taehong; Ko, Sung Hee; Hamel, Jean-Francois P; Han, Jongyoon

Year: 2020

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/125538

Thesis An Investigation of Multivariate Process Control for Biomanufacturing

Lui, Christopher A. · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: An Investigation of Multivariate Process Control for Biomanufacturing

Authors: Lui, Christopher A.

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/139505

Thesis Challenging the workhorse: Comparative analysis of eukaryotic micro‐organisms for expressing monoclonal antibodies

Jiang, Hanxiao; Horwitz, Andrew A; Wright, Chapman et al. · 2021 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Challenging the workhorse: Comparative analysis of eukaryotic micro‐organisms for expressing monoclonal antibodies

Authors: Jiang, Hanxiao; Horwitz, Andrew A; Wright, Chapman; Tai, Anna; Znameroski, Elizabeth A; Tsegaye, Yoseph; Warbington, Hailley; Bower, Benjamin S; Alves, Christina; Co, Carl; Jonnalagadda, Kanvasri; Platt, Darren; Walter, Jessica M; Natarajan, Venkatesh; Ubersax, Jeffrey A; Cherry, Joel R; Love, J Christopher

Year: 2021

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/134784

Thesis Enhancing Production of Recombinant Proteins from Mammalian Cells

Wong, Victor V.T.; Wong, Niki S.C.; Tan, Hong-Kiat et al. · 2003 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Enhancing Production of Recombinant Proteins from Mammalian Cells

Authors: Wong, Victor V.T.; Wong, Niki S.C.; Tan, Hong-Kiat; Wang, Daniel I.C.; Yap, Miranda G.S.

Year: 2003

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/3782

Thesis Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in Komagataella phaffii

Yang, Yuchen; Dalvie, Neil C; Brady, Joseph R et al. · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in Komagataella phaffii

Authors: Yang, Yuchen; Dalvie, Neil C; Brady, Joseph R; Naranjo, Christopher A; Lorgeree, Timothy; Rodriguez‐Aponte, Sergio A; Johnston, Ryan S; Tracey, Mary K; Elenberger, Carmen M; Lee, Eric; Tié, Mark; Love, Kerry R; Love, J Christopher

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/163225

Thesis Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool

Puarattana-aroonkorn, Sitthiphol; Tharakaraman, Kannan; Suriyawipada, Disapan et al. · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool

Authors: Puarattana-aroonkorn, Sitthiphol; Tharakaraman, Kannan; Suriyawipada, Disapan; Ruchirawat, Mathuros; Fuangthong, Mayuree; Sasisekharan, Ram; Artpradit, Charlermchai

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/155543

Thesis Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel et al. · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Authors: Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel; Dang, Brendan; Wolffe, Lenna A; Atari, Adel; Tseng, Yuen-Yi; Love, J Christopher

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/163220

Thesis Active Hypothermic Growth: A Novel Means For Increasing Total Interferon-γ Production by Chinese Hamster Ovary Cells

Stephen R., Fox; Yap, Mei Xia; Yap, Miranda G.S. et al. · 2005 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Active Hypothermic Growth: A Novel Means For Increasing Total Interferon-γ Production by Chinese Hamster Ovary Cells

Authors: Stephen R., Fox; Yap, Mei Xia; Yap, Miranda G.S.; Wang, Daniel I.C.

Year: 2005

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/30379

Thesis The Effect of Culture Temperature on Recombinant IFN-γ Production and Quality

Fox, Steven R.; Yap, Miranda G.S.; Wang, Daniel I.C. · 2003 · Massachusetts Institute of Technology (MIT) · DOI

Full title: The Effect of Culture Temperature on Recombinant IFN-γ Production and Quality

Authors: Fox, Steven R.; Yap, Miranda G.S.; Wang, Daniel I.C.

Year: 2003

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/3928

Thesis CIRP Expression on Growth and Productivity of CHO Cells

Tan, Hong-Kiat; Yap, Miranda G.S.; Wang, Daniel I.C. · 2005 · Massachusetts Institute of Technology (MIT) · DOI

Full title: CIRP Expression on Growth and Productivity of CHO Cells

Authors: Tan, Hong-Kiat; Yap, Miranda G.S.; Wang, Daniel I.C.

Year: 2005

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/30382

Thesis Reduced Temperature Production of Recombinant Proteins to Increase Productivity in Mammalian Cell Culture

Fox, Steven R.; Wang, Daniel I.C.; Yap, Miranda G.S. · 2003 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Reduced Temperature Production of Recombinant Proteins to Increase Productivity in Mammalian Cell Culture

Authors: Fox, Steven R.; Wang, Daniel I.C.; Yap, Miranda G.S.

Year: 2003

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/3946

Thesis Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins

Bosques, Carlos J.; Collins, Brian E.; Meador, James W. et al. · 2014 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins

Authors: Bosques, Carlos J.; Collins, Brian E.; Meador, James W.; Sarvaiya, Hetal; Murphy, Jennifer L.; DelloRusso, Guy; Bulik, Dorota A.; Hsu, I-Hsuan; Washburn, Nathaniel; Sipsey, Sandra F.; Myette, James R.; Raman, Rahul; Sasisekharan, Ram; Venkataraman, Ganesh; Shriver, Zachary H.

Year: 2014

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/89032

Thesis Variability in the Stability and Productivity of Transfected Genes in Chinese Hamster Ovary (CHO) cells

Ng, Say Kong; Yap, Miranda G.S.; Wang, Daniel I.C. · 2004 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Variability in the Stability and Productivity of Transfected Genes in Chinese Hamster Ovary (CHO) cells

Authors: Ng, Say Kong; Yap, Miranda G.S.; Wang, Daniel I.C.

Year: 2004

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/7504

Thesis Naming CHO cells for bio-manufacturing: Genome plasticity and variant phenotypes of cell populations in bioreactors question the relevance of old names

Wurm, Maria J.; Wurm, Florian M. · 2021 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Naming CHO cells for bio-manufacturing: Genome plasticity and variant phenotypes of cell populations in bioreactors question the relevance of old names

Authors: Wurm, Maria J.; Wurm, Florian M.

Year: 2021

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/179941

Thesis Trimeric SARS-CoV-2 Spike Proteins Produced from CHO Cells in Bioreactors Are High-Quality Antigens

Pino, Paco; Kint, Joeri; Kiseljak, Divor et al. · 2021 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Trimeric SARS-CoV-2 Spike Proteins Produced from CHO Cells in Bioreactors Are High-Quality Antigens

Authors: Pino, Paco; Kint, Joeri; Kiseljak, Divor; Agnolon, Valentina; Corradin, Giampietro; Kajava, Andrey V.; Rovero, Paolo; Dijkman, Ronald; den Hartog, Gerco; McLellan, Jason S.; Byrne, Patrick O.; Wurm, Maria J.; Wurm, Florian M.

Year: 2021

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/174671

Thesis Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection-A Simulation Study

Hernandez Rodriguez, Tanja; Morerod, Sophie; Poertner, Ralf et al. · 2021 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection-A Simulation Study

Authors: Hernandez Rodriguez, Tanja; Morerod, Sophie; Poertner, Ralf; Wurm, Florian M.; Frahm, Bjorn

Year: 2021

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/180009

Thesis A Robust, High-Titer, Semi-Automated, and In-Culture Antibody-Capturing Transient CHO Platform Technology

Gebhardt, L. P.; Abel, Molica; Zhou, Jing et al. · 2025 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A Robust, High-Titer, Semi-Automated, and In-Culture Antibody-Capturing Transient CHO Platform Technology

Authors: Gebhardt, L. P.; Abel, Molica; Zhou, Jing; Vogt, A; Shin, Bo Hee; Wagman, Sarah L. Herrick; Santos, Ana Luísa; Puginier, Jerome; Wurm, Florian Μ.; Wurm, Florian Μ.; Yan, Guoying; Adeniyi, Ade Fatai; Lim, Sean K. H.; Somers, Will; Lin, Laura; D’Antona, Aaron M.; Zhong, Xiaotian

Year: 2025

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/255058

Thesis Cloning of CHO Cells, Productivity and Genetic Stability—A Discussion

Wurm, Florian · 2020 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Cloning of CHO Cells, Productivity and Genetic Stability—A Discussion

Authors: Wurm, Florian

Year: 2020

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/169672

Thesis Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

Muller, N.; Derouazi, M.; Van Tilborgh, F. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

Authors: Muller, N.; Derouazi, M.; Van Tilborgh, F.; Wulhfard, S.; Hacker, D. L.; Jordan, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9754

Thesis A new approach for identifying positional isomers of glycans cleaved from monoclonal antibodies

Dyukova, Irina; Ben Faleh, Ahmed; Warnke, Stephan et al. · 2021 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A new approach for identifying positional isomers of glycans cleaved from monoclonal antibodies

Authors: Dyukova, Irina; Ben Faleh, Ahmed; Warnke, Stephan; Yalovenko, Natalia; Yatsyna, Vasyl; Bansal, Priyanka; Rizzo, Thomas R.

Year: 2021

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/179989

Thesis Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

Zhang, Xiaowei; Garcia, Isabel Fernandez; Baldi, Lucia et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

Authors: Zhang, Xiaowei; Garcia, Isabel Fernandez; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/52051

Thesis Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells

Davami, Fatemeh; Baldi, Lucia; Rajendra, Yashas et al. · 2014 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells

Authors: Davami, Fatemeh; Baldi, Lucia; Rajendra, Yashas; M Wurm, Florian

Year: 2014

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/108905

Thesis Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells

Meuwly, F.; von Stockar, U.; Kadouri, A. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells

Authors: Meuwly, F.; von Stockar, U.; Kadouri, A.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226104

Thesis OVEREXPRESSION OF SLC15A1 GENE IN CHO-S CELLS TO INCREASE DIPEPTIDE UPTAKE RATE

Liu, Shuman · 2021 · Johns Hopkins University · DOI

Full title: OVEREXPRESSION OF SLC15A1 GENE IN CHO-S CELLS TO INCREASE DIPEPTIDE UPTAKE RATE

Authors: Liu, Shuman

Year: 2021

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/64522

Thesis HIGH EFFICIENCY AFFINITY CAPTURE AND PURIFICATION OF IMMUNOGLOBULIN G USING MAGNETIC PARTICLES WITH BIOINSPIRIED PEPTIDE LIGANDS

Ou, Shih-Hao · 2019 · Johns Hopkins University · DOI

Full title: HIGH EFFICIENCY AFFINITY CAPTURE AND PURIFICATION OF IMMUNOGLOBULIN G USING MAGNETIC PARTICLES WITH BIOINSPIRIED PEPTIDE LIGANDS

Authors: Ou, Shih-Hao

Year: 2019

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/61606

Thesis Optimization of Recombinant Protein Production in Different Cell Lines

Ouyang, Chu · 2024 · Johns Hopkins University · DOI

Full title: Optimization of Recombinant Protein Production in Different Cell Lines

Authors: Ouyang, Chu

Year: 2024

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/69633

Thesis Improvement of Erythropoietin N-glycan Branching and Sialylation by Overexpression of Glycosyltransferases

Gao, Yuan · 2016 · Johns Hopkins University · DOI

Full title: Improvement of Erythropoietin N-glycan Branching and Sialylation by Overexpression of Glycosyltransferases

Authors: Gao, Yuan

Year: 2016

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/39421

Thesis Screening for Antibody Reduction at the Clone Selection Stage to Prevent Reduction During Manufacturing

Lakhani, Aliya Abdulaziz · 2019 · Johns Hopkins University · DOI

Full title: Screening for Antibody Reduction at the Clone Selection Stage to Prevent Reduction During Manufacturing

Authors: Lakhani, Aliya Abdulaziz

Year: 2019

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/60150

Thesis Protocol for production and expression of chimeric bovine-human monoclonal antibodies

Heydarchi, B; Purcell, DFJ · 2023 · University of Melbourne · DOI

Full title: Protocol for production and expression of chimeric bovine-human monoclonal antibodies

Authors: Heydarchi, B; Purcell, DFJ

Year: 2023

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/334751

Thesis Production and characterization of specific monoclonal antibodies binding the Plasmodium falciparum diagnostic biomarker, histidine-rich protein 2

Leow, CH; Jones, M; Cheng, Q et al. · 2021 · University of Melbourne · DOI

Full title: Production and characterization of specific monoclonal antibodies binding the Plasmodium falciparum diagnostic biomarker, histidine-rich protein 2

Authors: Leow, CH; Jones, M; Cheng, Q; Mahler, S; McCarthy, J

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/277268

Thesis Impact on product quality of high productive GS-CHO cell lines.

Perani, A; Gloria, B; Wang, D et al. · 2022 · University of Melbourne · DOI

Full title: Impact on product quality of high productive GS-CHO cell lines.

Authors: Perani, A; Gloria, B; Wang, D; Murphy, R; Singh, HK; Smyth, FE; Scott, AM

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/303930

Thesis A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments

Karimi Alavijeh, M; Lee, YY; Gras, SL · 2024 · University of Melbourne · DOI

Full title: A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments

Authors: Karimi Alavijeh, M; Lee, YY; Gras, SL

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/351093

Thesis Variations in critical quality attributes (CQAs) on therapeutic monoclonal antibodies (mAbs) due to cultivation conditions, storage conditions and external stress-factors

Nash, Felicia; Sannum, Emma · 2024 · Lund University Student Papers · DOI

Full title: Variations in critical quality attributes (CQAs) on therapeutic monoclonal antibodies (mAbs) due to cultivation conditions, storage conditions and external stress-factors

Authors: Nash, Felicia; Sannum, Emma

Year: 2024

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9170581

Thesis Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand

Chua, Gek Kee · 2011 · Massey University · DOI

Full title: Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand

Authors: Chua, Gek Kee

Year: 2011

Venue: Massey University

DOI: http://hdl.handle.net/10179/2832

Thesis FIA-Based Process Monitoring in Simulated Bioreactor for Monoclonal Antibody Production

Fernandez Alcantara, Leonardo Renzo · 2025 · Lund University Student Papers · DOI

Full title: FIA-Based Process Monitoring in Simulated Bioreactor for Monoclonal Antibody Production

Authors: Fernandez Alcantara, Leonardo Renzo

Year: 2025

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9188201

Thesis Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening

Kim, Su Hyun; Shin, Seunghyeon; Baek, Minhye et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening

Authors: Kim, Su Hyun; Shin, Seunghyeon; Baek, Minhye; Xiong, Kai; Karottki, Karen Julie la Cour; Hefzi, Hooman; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Kildegaard, Helene Faustrup; Lewis, Nathan E.; Lee, Jae Seong; Lee, Gyun Min

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/6d4a73c5-e3ad-45bb-bdcf-fcad2d316ad4

Thesis High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

Zhang, Ye · 2017 · KTH Royal Institute of Technology · DOI

Full title: High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

Authors: Zhang, Ye

Year: 2017

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-207600

Thesis Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium

Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Òdena, Andreu et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium

Authors: Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Òdena, Andreu; Karottki, Karen Julie la Cour; Kim, Che Lin; Hefzi, Hooman; Lee, Gyun Min; Faustrup Kildegaard, Helene; Nielsen, Lars K.; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lewis, Nathan E.

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9841cea8-7f15-4ec0-9c98-bc7dea65684a

Thesis Optimization of serum free medium for the production of humanized anti-cea monoclonal antibody.

Ab Latif, Nurzila · 2011 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Optimization of serum free medium for the production of humanized anti-cea monoclonal antibody.

Authors: Ab Latif, Nurzila

Year: 2011

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/26510/2/IB%202011%2030R.pdf

Thesis A versatile genomic transgenesis platform with enhanced λ integrase for human Expi293F cells

Siddiqui, Asim Azhar (Nanyang Technological University); Dröge, Peter (Nanyang Technological University); Günzburg, Walter H. (University of Veterinary Medicine Vienna / Austrianova Singapore Pte. Ltd.) et al. · 2023 · University of Veterinary Medicine Vienna (Vetmeduni Vienna) · DOI

Full title: A versatile genomic transgenesis platform with enhanced λ integrase for human Expi293F cells

Authors: Siddiqui, Asim Azhar (Nanyang Technological University); Dröge, Peter (Nanyang Technological University); Günzburg, Walter H. (University of Veterinary Medicine Vienna / Austrianova Singapore Pte. Ltd.); Dangerfield, John A. (Austrianova Singapore Pte. Ltd.); Ng, Shirelle (Austrianova Singapore Pte. Ltd.); Wang, Cheng-I (Agency for Science, Technology and Research (A*STAR)); Peter, Sabrina (Nanyang Technological University); Ngoh, Eve Zi Xian (Agency for Science, Technology and Research (A*STAR))

Year: 2023

Venue: University of Veterinary Medicine Vienna (Vetmeduni Vienna)

DOI: https://phaidra.vetmeduni.ac.at/o:2395

Thesis Development of a novel bioreactor and systems for suspension cell culture in biopharmaceutical production

Sharma, Rajesh · 2022 · University of Cape Town · DOI

Full title: Development of a novel bioreactor and systems for suspension cell culture in biopharmaceutical production

Authors: Sharma, Rajesh

Year: 2022

Venue: University of Cape Town

DOI: http://hdl.handle.net/11427/36112

Thesis Sobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes

Bulté Ocaña, Dubhe Beatriz · 2021 · Universidad Nacional Autónoma de México (UNAM) · DOI

Full title: Sobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes

Authors: Bulté Ocaña, Dubhe Beatriz

Year: 2021

Venue: Universidad Nacional Autónoma de México (UNAM)

DOI: https://hdl.handle.net/20.500.14330/TES01000806237

Thesis Improving protein yield from mammalian cells by manipulation of stress response pathways

Chalmers, Fiona · 2016 · University of Glasgow · DOI

Full title: Improving protein yield from mammalian cells by manipulation of stress response pathways

Authors: Chalmers, Fiona

Year: 2016

Venue: University of Glasgow

DOI: https://theses.gla.ac.uk/7666/7/2016ChalmersPhD.pdf

Thesis Impact de la modification du métabolisme primaire des cellules CHO sur leur productivité

Toussaint, Cecile · 2017 · Université de Montréal (Papyrus) · DOI

Full title: Impact de la modification du métabolisme primaire des cellules CHO sur leur productivité

Authors: Toussaint, Cecile

Year: 2017

Venue: Université de Montréal (Papyrus)

DOI: http://hdl.handle.net/1866/18549

Thesis Recombinant protein production utilising a metallothionein expression system and a Super-CHO cell line

Huang, Edwin P.C. · 2006 · UNSW Sydney · DOI

Full title: Recombinant protein production utilising a metallothionein expression system and a Super-CHO cell line

Authors: Huang, Edwin P.C.

Year: 2006

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/24940

Thesis Transient production of biopharmaceutical proteins

Wei, Tzu-Hsiang · 2009 · UNSW Sydney · DOI

Full title: Transient production of biopharmaceutical proteins

Authors: Wei, Tzu-Hsiang

Year: 2009

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/43708

Thesis Effects of imperfect mixing in suspended plant and animal cell cultures

Cheung, Caleb Kin Lok · 2006 · UNSW Sydney · DOI

Full title: Effects of imperfect mixing in suspended plant and animal cell cultures

Authors: Cheung, Caleb Kin Lok

Year: 2006

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/25200

Thesis The Biological Impact of High Throughput Continuous Bioprocessing

Sewell, David John · 2020 · University of Cambridge · DOI

Full title: The Biological Impact of High Throughput Continuous Bioprocessing

Authors: Sewell, David John

Year: 2020

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/311711

Thesis Appendix for: "Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch"

Gangadharan, Nishanthi · 2023 · University of Cambridge · DOI

Full title: Appendix for: "Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch"

Authors: Gangadharan, Nishanthi

Year: 2023

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/347248

Thesis A study of apoptosis and cell cycle to augment transfection efficiency in CHO cell lines

Wanandy, Nico Stanislaus · 2007 · UNSW Sydney · DOI

Full title: A study of apoptosis and cell cycle to augment transfection efficiency in CHO cell lines

Authors: Wanandy, Nico Stanislaus

Year: 2007

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/40868

Thesis Construction, expression and characterisation of a human anti-CD48 monoclonal antibody

Wei, Jiewei · 2006 · UNSW Sydney · DOI

Full title: Construction, expression and characterisation of a human anti-CD48 monoclonal antibody

Authors: Wei, Jiewei

Year: 2006

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/27413

Thesis Investigation of the factors affecting serum-free growth of the animal cell line CHO K1

Bridges, Michael · 1995 · UNSW Sydney · DOI

Full title: Investigation of the factors affecting serum-free growth of the animal cell line CHO K1

Authors: Bridges, Michael

Year: 1995

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/57409

Thesis Increasing biomass production in bioreactors applying metabolic analysis and engineering tools

Comas Sanchez, Pere · 2021 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Increasing biomass production in bioreactors applying metabolic analysis and engineering tools

Authors: Comas Sanchez, Pere

Year: 2021

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/671074

Thesis Development of tools for monitoring and controlling cell cultures through the metabolic analysis

Martínez Monge, Iván · 2018 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Development of tools for monitoring and controlling cell cultures through the metabolic analysis

Authors: Martínez Monge, Iván

Year: 2018

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/664350

Thesis Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.

Kumpel, Belinda M; Saldova, Radka; Koeleman, Carolien AM et al. · 2021 · University of Cambridge · DOI

Full title: Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.

Authors: Kumpel, Belinda M; Saldova, Radka; Koeleman, Carolien AM; Abrahams, Jodie L; Ederveen, Agnes Hipgrave; Armour, Kathryn L; Olovnikova, Natalia I; Vidarsson, Gestur; Kapur, Rick; Rudd, Pauline M; Wuhrer, Manfred

Year: 2021

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/316867

Thesis Enhancing the Functionality of a Microscale Bioreactor System as an Industrial Process Development Tool for Mammalian Perfusion Culture

Sewell, David J; Turner, Richard; Field, Ray et al. · 2019 · University of Cambridge · DOI

Full title: Enhancing the Functionality of a Microscale Bioreactor System as an Industrial Process Development Tool for Mammalian Perfusion Culture

Authors: Sewell, David J; Turner, Richard; Field, Ray; Holmes, William; Pradhan, Rahul; Spencer, Christopher; Oliver, Stephen; Slater, Nigel; Dikicioglu, Duygu

Year: 2019

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/289313

Thesis Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.

Traustason, Bergthor; Cheeks, Matthew; Dikicioglu, Duygu · 2020 · University of Cambridge · DOI

Full title: Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.

Authors: Traustason, Bergthor; Cheeks, Matthew; Dikicioglu, Duygu

Year: 2020

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/301284

Thesis Challenges and Opportunities for the Large-Scale Chemoenzymatic Glycoengineering of Therapeutic N-Glycosylated Monoclonal Antibodies

Ivanova, Adelina; Falcioni, Francesco · 2022 · University of Cambridge · DOI

Full title: Challenges and Opportunities for the Large-Scale Chemoenzymatic Glycoengineering of Therapeutic N-Glycosylated Monoclonal Antibodies

Authors: Ivanova, Adelina; Falcioni, Francesco

Year: 2022

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/334145

Thesis Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Murayyan, Abdulmonem · 2013 · University of Guelph · DOI

Full title: Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Authors: Murayyan, Abdulmonem

Year: 2013

Venue: University of Guelph

DOI: http://hdl.handle.net/10214/6604

Thesis The Assessment of MAb Quality and Quantity

Drouillard, Gerald · 2015 · University of Guelph · DOI

Full title: The Assessment of MAb Quality and Quantity

Authors: Drouillard, Gerald

Year: 2015

Venue: University of Guelph

DOI: http://hdl.handle.net/10214/8743

Thesis Genomic and transcriptomic approaches for the advancement of CHO cell bioprocessing

Vishwanathan, Nandita · 2014 · University of Minnesota - Digital Conservancy · DOI

Full title: Genomic and transcriptomic approaches for the advancement of CHO cell bioprocessing

Authors: Vishwanathan, Nandita

Year: 2014

Venue: University of Minnesota - Digital Conservancy

DOI: http://hdl.handle.net/11299/165110

Thesis Computational Fluid Dynamics Simulations of Single-Use Bioreactors for the Scale-Up of Cell Culture Processes

Kreitmayer, Diana · 2022 · Heidelberg University · DOI

Full title: Computational Fluid Dynamics Simulations of Single-Use Bioreactors for the Scale-Up of Cell Culture Processes

Authors: Kreitmayer, Diana

Year: 2022

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/32116/1/DissertationDianaKreitmayer.pdf

Thesis Methods for cell line and protein engineering

Lundqvist, Magnus · 2018 · KTH Royal Institute of Technology · DOI

Full title: Methods for cell line and protein engineering

Authors: Lundqvist, Magnus

Year: 2018

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-227195

Thesis Macroscopic models of Chinese hamster ovary cell cultures

Hagrot, Erika · 2019 · KTH Royal Institute of Technology · DOI

Full title: Macroscopic models of Chinese hamster ovary cell cultures

Authors: Hagrot, Erika

Year: 2019

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-262850

Thesis Cell line and protein engineering tools for production and characterization of biologics

Volk, Anna-Luisa · 2017 · KTH Royal Institute of Technology · DOI

Full title: Cell line and protein engineering tools for production and characterization of biologics

Authors: Volk, Anna-Luisa

Year: 2017

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-212931

Thesis Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022 · KTH Royal Institute of Technology · DOI

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

Year: 2022

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis Magnetic bead-based isolation of biological therapeutic modalities

Brechmann, Nils A. · 2022 · KTH Royal Institute of Technology · DOI

Full title: Magnetic bead-based isolation of biological therapeutic modalities

Authors: Brechmann, Nils A.

Year: 2022

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-321336

Thesis A computational framework for predicting CHO cell culture performance in bioreactors

Cárcamo Behrens, Martín. · 2019 · Massachusetts Institute of Technology (MIT) · DOI

Full title: A computational framework for predicting CHO cell culture performance in bioreactors

Authors: Cárcamo Behrens, Martín.

Year: 2019

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/123055

Thesis Recycling and Regeneration of Spent Perfusion Media via Ion Concentration Polarization

Wynne, Eric Michael · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Recycling and Regeneration of Spent Perfusion Media via Ion Concentration Polarization

Authors: Wynne, Eric Michael

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/164151

Thesis Glycosylation site occupancy heterogeneity in Chinese hamster ovary cell culture

Nyberg, Gregg B. (Gregg Bartell), 1970- · 2005 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Glycosylation site occupancy heterogeneity in Chinese hamster ovary cell culture

Authors: Nyberg, Gregg B. (Gregg Bartell), 1970-

Year: 2005

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/28190

Thesis Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays

Rohskopf, Zhumei · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays

Authors: Rohskopf, Zhumei

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/152457

Thesis Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Maloney, Andrew John · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Authors: Maloney, Andrew John

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/158315

Thesis Increasing IFN-[gamma] productivity in CHO cells through CDK inhibition

McClain, David Alan · 2010 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Increasing IFN-[gamma] productivity in CHO cells through CDK inhibition

Authors: McClain, David Alan

Year: 2010

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/60138

Thesis Systems Engineering for Viral Vector Manufacturing

Nguyen, Tam Ngoc Thanh · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Systems Engineering for Viral Vector Manufacturing

Authors: Nguyen, Tam Ngoc Thanh

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/150243

Thesis Active hypothermic growth : a novel means for increasing total recombinant protein production by CHO cells

Fox, Stephen Richard · 2008 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Active hypothermic growth : a novel means for increasing total recombinant protein production by CHO cells

Authors: Fox, Stephen Richard

Year: 2008

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://dspace.mit.edu/handle/1721.1/32333

Thesis Comparison of the growth and monoclonal antibody production of suspended mammalian cells in three perfusion systems

Hufford, Kathy (Kathy E.) · 2008 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Comparison of the growth and monoclonal antibody production of suspended mammalian cells in three perfusion systems

Authors: Hufford, Kathy (Kathy E.)

Year: 2008

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/39921

Thesis Molecular, Genetic, and Process Approaches for Improving Secreted Pharmaceutical Protein Quality in Komagataella phaffii

Yang, Yuchen · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Molecular, Genetic, and Process Approaches for Improving Secreted Pharmaceutical Protein Quality in Komagataella phaffii

Authors: Yang, Yuchen

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/157251

Thesis Enhancing mammalian bioprocessing through engineering Chinese hamster ovary cell metabolism

Hefzi, Hooman · 2018 · University of California, San Diego (UCSD) · DOI

Full title: Enhancing mammalian bioprocessing through engineering Chinese hamster ovary cell metabolism

Authors: Hefzi, Hooman

Year: 2018

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/91h2z79t

Thesis Characterization of the down regulation of antibody production in high cell density perfusion culture

Morrill, Joyce Catherine · 2006 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Characterization of the down regulation of antibody production in high cell density perfusion culture

Authors: Morrill, Joyce Catherine

Year: 2006

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/32602

Thesis Strategies to improve protein production of Chinese hamster ovary cell lines and genome annotation under the guidance of high throughput omics technology

Li, Shangzhong · 2019 · University of California, San Diego (UCSD) · DOI

Full title: Strategies to improve protein production of Chinese hamster ovary cell lines and genome annotation under the guidance of high throughput omics technology

Authors: Li, Shangzhong

Year: 2019

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/1d30f4xc

Thesis Molecular dynamics of monoclonal antibody production in high density perfused bioreactors

Buser, Claudia Waltraut · 2008 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Molecular dynamics of monoclonal antibody production in high density perfused bioreactors

Authors: Buser, Claudia Waltraut

Year: 2008

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/43915

Thesis Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Cosenza, Zachary Anthony · 2022 · University of California, Davis · DOI

Full title: Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Authors: Cosenza, Zachary Anthony

Year: 2022

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/119489fc

Thesis Quantitative Analysis of Proteome Dynamics in Chinese Hamster Ovary cells

Florczak, Beata D · 2019 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Quantitative Analysis of Proteome Dynamics in Chinese Hamster Ovary cells

Authors: Florczak, Beata D

Year: 2019

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/25823/1/B.Florczak_thesis.pdf

Thesis Applications of Protein Engineering in Synthetic Biology and Bioproduction

Minami, Shiaki · 2023 · University of California, Davis · DOI

Full title: Applications of Protein Engineering in Synthetic Biology and Bioproduction

Authors: Minami, Shiaki

Year: 2023

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/8p08541h

Thesis Engineering Oxidative Stress Resistance in CHO Cell Factories

Fairbrass, Danielle L · 2016 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Engineering Oxidative Stress Resistance in CHO Cell Factories

Authors: Fairbrass, Danielle L

Year: 2016

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/16227/1/Master_Copy_DLFairbrassThesis.pdf

Thesis High-Throughput Platform Development for Chinese Hamster Ovary (CHO) Cell Culture Performance Enhancement Using Small Molecules.

Kalsi, Devika · 2018 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: High-Throughput Platform Development for Chinese Hamster Ovary (CHO) Cell Culture Performance Enhancement Using Small Molecules.

Authors: Kalsi, Devika

Year: 2018

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/23127/1/Devika%20Kalsi%20PhD%20Thesis_corrected%20copy.pdf

Thesis Multigene engineering of secretion in mammalian cell factories

Barber, Nicholas · 2019 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Multigene engineering of secretion in mammalian cell factories

Authors: Barber, Nicholas

Year: 2019

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/25495/1/FINALPDF%20NB%20Jun19%20corrections%20Multigene%20engineering%20of%20secretion%20in%20mammalian%20cell%20factories.pdf

Thesis Investigating the rules governing N-linked glycosylation of Biologics

Ayre, Josephine · 2023 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Investigating the rules governing N-linked glycosylation of Biologics

Authors: Ayre, Josephine

Year: 2023

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/34913/1/Ayre_204009713_CorrectedThesisClean2.pdf

Thesis Manipulation of Endoplasmic Reticulum Folding and Assembly Machinery for Improved Production of Complex Biotherapeutics

Swindley, Oscar · 2021 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Manipulation of Endoplasmic Reticulum Folding and Assembly Machinery for Improved Production of Complex Biotherapeutics

Authors: Swindley, Oscar

Year: 2021

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/29353/1/Oscar_Swindley_Thesis_Corrected_FinalAmendment_Aug2021.pdf

Thesis Screening and development of natural compounds as tools to improve IgG production and quality in recombinant CHO cell culture

Toronjo Urquiza, Luis · 2018 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Screening and development of natural compounds as tools to improve IgG production and quality in recombinant CHO cell culture

Authors: Toronjo Urquiza, Luis

Year: 2018

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/25707/1/Screening%20and%20development%20of%20natural%20compounds%20as%20tools%20to%20improve%20IgG%20production%20and%20quality%20in%20recombinant%20CHO%20cell%20culture%20final.pdf

Thesis Characterisation of Cell Lines with Engineered Golgi Organisation

Spencer, Hannah · 2022 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Characterisation of Cell Lines with Engineered Golgi Organisation

Authors: Spencer, Hannah

Year: 2022

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/31162/1/HannahSpencerThesis.pdf

Thesis CHO cell multigene engineering by directed evolution

Jawara, Chillel · 2023 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: CHO cell multigene engineering by directed evolution

Authors: Jawara, Chillel

Year: 2023

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/36961/1/Jawara_Chillel_190186993_PhDThesis_Final.pdf

Thesis Using Emerging Next-Generation Sequencing Technologies to Enhance the Lifecycle of Biopharmaceuticals

shamie, isaac · 2022 · University of California, San Diego (UCSD) · DOI

Full title: Using Emerging Next-Generation Sequencing Technologies to Enhance the Lifecycle of Biopharmaceuticals

Authors: shamie, isaac

Year: 2022

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/55x7t985

Thesis Integrated cell and bioprocess engineering for rapid and intensive continuous production of biopharmaceuticals

Morgan-Evans, William · 2020 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Integrated cell and bioprocess engineering for rapid and intensive continuous production of biopharmaceuticals

Authors: Morgan-Evans, William

Year: 2020

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/29148/1/Integrated%20cell%20and%20bioprocess%20engineering%20for%20rapid%20and%20intensive%20continuous%20production%20of%20biopharmaceuticals%2C%20William%20Morgan-Evans%20%282020%29.pdf

Thesis Developing novel biosensors for monitoring antibody production in Chinese Hamster Ovary (CHO) cells

Willmott, Jessica · 2022 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Developing novel biosensors for monitoring antibody production in Chinese Hamster Ovary (CHO) cells

Authors: Willmott, Jessica

Year: 2022

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/32583/1/Willmott%2C%20Jessica%2C%20170246628%20-%20Complete%20with%20Corrections.pdf

Thesis Use of CHO cell synthetic promoters to control transcription of mAb expression vector genes and screening of ER genes for their effect on mAb production

Kerry, William · 2022 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Use of CHO cell synthetic promoters to control transcription of mAb expression vector genes and screening of ER genes for their effect on mAb production

Authors: Kerry, William

Year: 2022

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/32010/2/William%20Kerry%20Corrected%20PhD%20thesis%20November%202022%20minus%20appendix.pdf

Thesis Adaptation to suspension growth: analysing the surface of suspension growth adapted Chinese hamster ovary cells

Walther, Christa G · 2013 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Adaptation to suspension growth: analysing the surface of suspension growth adapted Chinese hamster ovary cells

Authors: Walther, Christa G

Year: 2013

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/4193/1/final_version_-_all_chapters.pdf

Thesis Development of an integrated platform for the production of recombinant biopharmaceuticals

Segarra, Camille · 2013 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Development of an integrated platform for the production of recombinant biopharmaceuticals

Authors: Segarra, Camille

Year: 2013

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/4147/1/Segarra_Thesis_PostCorrections.pdf

Thesis Characterising Chinese Hamster Ovary Cell Extracellular Vesicle Production in Biopharmaceutical Manufacturing

O'Donnell, Fergal · 2022 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Characterising Chinese Hamster Ovary Cell Extracellular Vesicle Production in Biopharmaceutical Manufacturing

Authors: O'Donnell, Fergal

Year: 2022

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/33062/1/Thesis_Corrections.pdf

Thesis The role of intracellular signalling pathways in CHO cell growth in a synthetic environment

Whitfield, Robert · 2014 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: The role of intracellular signalling pathways in CHO cell growth in a synthetic environment

Authors: Whitfield, Robert

Year: 2014

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/6454/1/Rob%20Whitfield%20Final%20Thesis%20Submission.pdf

Thesis Cell Line and Process Development for Improved Transient Production of a "Difficult-to-Express" Fusion Protein by CHO Cells

Johari, YB · 2015 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Cell Line and Process Development for Improved Transient Production of a "Difficult-to-Express" Fusion Protein by CHO Cells

Authors: Johari, YB

Year: 2015

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/9265/1/PhD%20thesis%20-%20YB%20Johari%20%5BFINAL%5D.pdf

Thesis Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

Zagari, Francesca · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

Authors: Zagari, Francesca

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/84627

Thesis OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up

Tissot, Stéphanie · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up

Authors: Tissot, Stéphanie

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/68752

Thesis Study of transposon-mediated cell pool and cell line generation in CHO cells

Balasubramanian, Sowmya · 2015 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Study of transposon-mediated cell pool and cell line generation in CHO cells

Authors: Balasubramanian, Sowmya

Year: 2015

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/113896

Thesis Influence of cell-line and process conditions on the glycosylation of recombinant proteins

Nahrgang, Stefan · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Influence of cell-line and process conditions on the glycosylation of recombinant proteins

Authors: Nahrgang, Stefan

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/211632

Thesis Transient gene expression for rapid protein production : studies & optimizations under serum-free conditions

Muller, Natalie · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transient gene expression for rapid protein production : studies & optimizations under serum-free conditions

Authors: Muller, Natalie

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/214287

Thesis ELUCIDATING MAMMALIAN CELL METABOLISM USING ‘OMICS TO ENHANCE BIOPROCESS CAPABILITIES

Dhara, Venkata Gayatri · 2022 · Johns Hopkins University · DOI

Full title: ELUCIDATING MAMMALIAN CELL METABOLISM USING ‘OMICS TO ENHANCE BIOPROCESS CAPABILITIES

Authors: Dhara, Venkata Gayatri

Year: 2022

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/66775

Thesis CELL ENGINEERING AND CULTURE MEDIA MODIFICATION STUDIES TO IMPROVE THE CELL CULTURE PERFORMANCE

Dhara, Venkata Gayatri · 2019 · Johns Hopkins University · DOI

Full title: CELL ENGINEERING AND CULTURE MEDIA MODIFICATION STUDIES TO IMPROVE THE CELL CULTURE PERFORMANCE

Authors: Dhara, Venkata Gayatri

Year: 2019

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/60428

Thesis Glycoengineering of Chinese Hamster Ovary cells for improving biotherapeutics’ efficacies.

Chung, Cheng-yu · 2019 · Johns Hopkins University · DOI

Full title: Glycoengineering of Chinese Hamster Ovary cells for improving biotherapeutics’ efficacies.

Authors: Chung, Cheng-yu

Year: 2019

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/60731

Thesis Predictive models for upstream mammalian cell culture development: a review

Yatipanthalawa, BS; Gras, SL · 2023 · University of Melbourne · DOI

Full title: Predictive models for upstream mammalian cell culture development: a review

Authors: Yatipanthalawa, BS; Gras, SL

Year: 2023

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/339523

Thesis Probing Control : Analysis and Design with Application to Fed-Batch Bioreactors

Velut, Stéphane · 2005 · Lund University (LUP) · DOI

Full title: Probing Control : Analysis and Design with Application to Fed-Batch Bioreactors

Authors: Velut, Stéphane

Year: 2005

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/24605

Thesis Rapid Media Transition for Metabolic Control Analysis of Fed-Batch Fermentation Processes

Link, Hannes Peter · 2009 · Technical University of Munich · DOI

Full title: Rapid Media Transition for Metabolic Control Analysis of Fed-Batch Fermentation Processes

Authors: Link, Hannes Peter

Year: 2009

Venue: Technical University of Munich

DOI: https://mediatum.ub.tum.de/796895

Thesis Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Hong, Moo Sun · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Authors: Hong, Moo Sun

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/138943

Patent us-9868940-b2

· 2018

Full title: us-9868940-b2

Year: 2018

Patent us-9650612-b2

· 2017

Full title: us-9650612-b2

Year: 2017

Patent us-re39792-e

· 2007

Full title: us-re39792-e

Year: 2007

Patent us-re41974-e

· 2010

Full title: us-re41974-e

Year: 2010

Patent us-9944968-b2

· 2018

Full title: us-9944968-b2

Year: 2018

Patent us-2017107551-a1

· 2017

Full title: us-2017107551-a1

Year: 2017

Patent us-2017166923-a1

· 2017

Full title: us-2017166923-a1

Year: 2017

Patent us-2017129936-a1

· 2017

Full title: us-2017129936-a1

Year: 2017

Patent us-2017218328-a1

· 2017

Full title: us-2017218328-a1

Year: 2017

Patent us-2017321240-a1

· 2017

Full title: us-2017321240-a1

Year: 2017

Patent us-2017204446-a1

· 2017

Full title: us-2017204446-a1

Year: 2017

Patent us-2017327558-a1

· 2017

Full title: us-2017327558-a1

Year: 2017

Patent us-2018030139-a1

· 2018

Full title: us-2018030139-a1

Year: 2018

Patent us-2018030495-a1

· 2018

Full title: us-2018030495-a1

Year: 2018

Patent us-2018251716-a1

· 2018

Full title: us-2018251716-a1

Year: 2018

Patent us-2018265904-a1

· 2018

Full title: us-2018265904-a1

Year: 2018

Patent us-2018051261-a1

· 2018

Full title: us-2018051261-a1

Year: 2018

Patent us-2019023800-a1

· 2019

Full title: us-2019023800-a1

Year: 2019

Patent us-2018346881-a1

· 2018

Full title: us-2018346881-a1

Year: 2018

Patent us-2018312811-a1

· 2018

Full title: us-2018312811-a1

Year: 2018

Patent us-2019225694-a1

· 2019

Full title: us-2019225694-a1

Year: 2019

Patent us-2019031997-a1

· 2019

Full title: us-2019031997-a1

Year: 2019

Patent us-2019010531-a1

· 2019

Full title: us-2019010531-a1

Year: 2019

Patent us-2019153400-a1

· 2019

Full title: us-2019153400-a1

Year: 2019

Patent us-2019161759-a1

· 2019

Full title: us-2019161759-a1

Year: 2019

Patent us-2019048070-a1

· 2019

Full title: us-2019048070-a1

Year: 2019

Patent us-2019055513-a1

· 2019

Full title: us-2019055513-a1

Year: 2019

Patent us-2019161543-a1

· 2019

Full title: us-2019161543-a1

Year: 2019

Patent us-2019085369-a1

· 2019

Full title: us-2019085369-a1

Year: 2019

Patent us-2019225934-a1

· 2019

Full title: us-2019225934-a1

Year: 2019

Patent us-2019263921-a1

· 2019

Full title: us-2019263921-a1

Year: 2019

Patent us-2019093142-a1

· 2019

Full title: us-2019093142-a1

Year: 2019

Patent us-2019233842-a1

· 2019

Full title: us-2019233842-a1

Year: 2019

Patent us-2019375835-a1

· 2019

Full title: us-2019375835-a1

Year: 2019

Patent us-2020131251-a1

· 2020

Full title: us-2020131251-a1

Year: 2020

Patent us-2020199525-a1

· 2020

Full title: us-2020199525-a1

Year: 2020

Patent us-2020123244-a1

· 2020

Full title: us-2020123244-a1

Year: 2020

Patent us-2019203249-a1

· 2019

Full title: us-2019203249-a1

Year: 2019

Patent us-2019276846-a1

· 2019

Full title: us-2019276846-a1

Year: 2019

Patent us-2020080049-a1

· 2020

Full title: us-2020080049-a1

Year: 2020

Patent us-2020181669-a1

· 2020

Full title: us-2020181669-a1

Year: 2020

Patent us-2020377849-a1

· 2020

Full title: us-2020377849-a1

Year: 2020

Patent us-2020149081-a1

· 2020

Full title: us-2020149081-a1

Year: 2020

Patent us-2020080125-a1

· 2020

Full title: us-2020080125-a1

Year: 2020

Patent us-2021002384-a1

· 2021

Full title: us-2021002384-a1

Year: 2021

Patent us-2020325441-a1

· 2020

Full title: us-2020325441-a1

Year: 2020

Patent us-2020255880-a1

· 2020

Full title: us-2020255880-a1

Year: 2020

Patent us-2020347383-a1

· 2020

Full title: us-2020347383-a1

Year: 2020

Patent us-2020223913-a1

· 2020

Full title: us-2020223913-a1

Year: 2020

Patent us-2021222109-a1

· 2021

Full title: us-2021222109-a1

Year: 2021

Patent us-2021009988-a1

· 2021

Full title: us-2021009988-a1

Year: 2021

Patent us-2021017553-a1

· 2021

Full title: us-2021017553-a1

Year: 2021

Patent us-2021002646-a1

· 2021

Full title: us-2021002646-a1

Year: 2021

Patent us-2021214702-a1

· 2021

Full title: us-2021214702-a1

Year: 2021

Patent us-2021087535-a1

· 2021

Full title: us-2021087535-a1

Year: 2021

Patent us-2021292783-a1

· 2021

Full title: us-2021292783-a1

Year: 2021

Patent us-2021238644-a1

· 2021

Full title: us-2021238644-a1

Year: 2021

Patent us-2021253996-a1

· 2021

Full title: us-2021253996-a1

Year: 2021

Patent us-2021332402-a1

· 2021

Full title: us-2021332402-a1

Year: 2021

Patent us-2021317435-a1

· 2021

Full title: us-2021317435-a1

Year: 2021

Patent us-2021388407-a1

· 2021

Full title: us-2021388407-a1

Year: 2021

Patent us-2021317395-a1

· 2021

Full title: us-2021317395-a1

Year: 2021

Patent us-2021246478-a1

· 2021

Full title: us-2021246478-a1

Year: 2021

Patent us-2021381020-a1

· 2021

Full title: us-2021381020-a1

Year: 2021

Patent us-2021254050-a1

· 2021

Full title: us-2021254050-a1

Year: 2021

Patent us-2021380923-a1

· 2021

Full title: us-2021380923-a1

Year: 2021

Patent us-2022089775-a1

· 2022

Full title: us-2022089775-a1

Year: 2022

Patent us-2021340481-a1

· 2021

Full title: us-2021340481-a1

Year: 2021

Patent us-2022154207-a1

· 2022

Full title: us-2022154207-a1

Year: 2022

Patent us-2021324098-a1

· 2021

Full title: us-2021324098-a1

Year: 2021

Patent us-2022154137-a1

· 2022

Full title: us-2022154137-a1

Year: 2022

Patent us-2022089761-a1

· 2022

Full title: us-2022089761-a1

Year: 2022

Patent us-2022064591-a1

· 2022

Full title: us-2022064591-a1

Year: 2022

Patent us-2022195478-a1

· 2022

Full title: us-2022195478-a1

Year: 2022

Patent us-2022228107-a1

· 2022

Full title: us-2022228107-a1

Year: 2022

Patent us-2022220509-a1

· 2022

Full title: us-2022220509-a1

Year: 2022

Patent us-2022228187-a1

· 2022

Full title: us-2022228187-a1

Year: 2022

Patent us-2022315644-a1

· 2022

Full title: us-2022315644-a1

Year: 2022

Patent us-2022348977-a1

· 2022

Full title: us-2022348977-a1

Year: 2022

Patent us-2022333054-a1

· 2022

Full title: us-2022333054-a1

Year: 2022

Patent us-2022315887-a1

· 2022

Full title: us-2022315887-a1

Year: 2022

Patent us-2022282298-a1

· 2022

Full title: us-2022282298-a1

Year: 2022

Patent us-2022396776-a1

· 2022

Full title: us-2022396776-a1

Year: 2022

Patent us-2023235062-a1

· 2023

Full title: us-2023235062-a1

Year: 2023

Patent us-2022372436-a1

· 2022

Full title: us-2022372436-a1

Year: 2022

Patent us-2023203449-a1

· 2023

Full title: us-2023203449-a1

Year: 2023

Patent us-2023193341-a1

· 2023

Full title: us-2023193341-a1

Year: 2023

Patent us-2022380827-a1

· 2022

Full title: us-2022380827-a1

Year: 2022

Patent us-2023106023-a1

· 2023

Full title: us-2023106023-a1

Year: 2023

Patent us-2023313125-a1

· 2023

Full title: us-2023313125-a1

Year: 2023

Patent us-2023250399-a1

· 2023

Full title: us-2023250399-a1

Year: 2023

Patent us-2023331776-a1

· 2023

Full title: us-2023331776-a1

Year: 2023

Patent us-2023332201-a1

· 2023

Full title: us-2023332201-a1

Year: 2023

Patent us-2023234995-a1

· 2023

Full title: us-2023234995-a1

Year: 2023

Patent us-2023287043-a1

· 2023

Full title: us-2023287043-a1

Year: 2023

Patent us-2023235318-a1

· 2023

Full title: us-2023235318-a1

Year: 2023

Patent us-2023287322-a1

· 2023

Full title: us-2023287322-a1

Year: 2023

Patent us-2023348532-a1

· 2023

Full title: us-2023348532-a1

Year: 2023

Patent us-2024002772-a1

· 2024

Full title: us-2024002772-a1

Year: 2024

Patent us-2023365920-a1

· 2023

Full title: us-2023365920-a1

Year: 2023

Patent us-2023332198-a1

· 2023

Full title: us-2023332198-a1

Year: 2023

Patent us-2024043879-a1

· 2024

Full title: us-2024043879-a1

Year: 2024

Patent us-2023323421-a1

· 2023

Full title: us-2023323421-a1

Year: 2023

Patent us-2023332084-a1

· 2023

Full title: us-2023332084-a1

Year: 2023

Patent us-2024010737-a1

· 2024

Full title: us-2024010737-a1

Year: 2024

Patent us-2024132835-a1

· 2024

Full title: us-2024132835-a1

Year: 2024

Patent us-2023374064-a1

· 2023

Full title: us-2023374064-a1

Year: 2023

Patent us-2024076626-a1

· 2024

Full title: us-2024076626-a1

Year: 2024

Patent us-2024002483-a1

· 2024

Full title: us-2024002483-a1

Year: 2024

Patent us-2024167006-a1

· 2024

Full title: us-2024167006-a1

Year: 2024

Patent us-2024093143-a1

· 2024

Full title: us-2024093143-a1

Year: 2024

Patent us-2024228948-a9

· 2024

Full title: us-2024228948-a9

Year: 2024

Patent us-2024093248-a1

· 2024

Full title: us-2024093248-a1

Year: 2024

Patent us-2024174752-a1

· 2024

Full title: us-2024174752-a1

Year: 2024

Patent us-2024010709-a1

· 2024

Full title: us-2024010709-a1

Year: 2024

Patent us-2024083972-a1

· 2024

Full title: us-2024083972-a1

Year: 2024

Patent us-2024052392-a1

· 2024

Full title: us-2024052392-a1

Year: 2024

Patent us-2024425894-a1

· 2024

Full title: us-2024425894-a1

Year: 2024

Patent us-2024309073-a1

· 2024

Full title: us-2024309073-a1

Year: 2024

Patent us-2024287207-a1

· 2024

Full title: us-2024287207-a1

Year: 2024

Patent us-2024318114-a1

· 2024

Full title: us-2024318114-a1

Year: 2024

Patent us-2024287152-a1

· 2024

Full title: us-2024287152-a1

Year: 2024

Patent us-2025034521-a1

· 2025

Full title: us-2025034521-a1

Year: 2025

Patent us-2024158754-a1

· 2024

Full title: us-2024158754-a1

Year: 2024

Patent us-2025019419-a1

· 2025

Full title: us-2025019419-a1

Year: 2025

Patent us-2024392315-a1

· 2024

Full title: us-2024392315-a1

Year: 2024

Patent us-2025066491-a1

· 2025

Full title: us-2025066491-a1

Year: 2025

Patent us-2025059486-a1

· 2025

Full title: us-2025059486-a1

Year: 2025

Patent us-2025027051-a1

· 2025

Full title: us-2025027051-a1

Year: 2025

Patent us-2025066493-a1

· 2025

Full title: us-2025066493-a1

Year: 2025

Patent us-2024400658-a1

· 2024

Full title: us-2024400658-a1

Year: 2024

Patent us-2025066718-a1

· 2025

Full title: us-2025066718-a1

Year: 2025

Patent us-2025087302-a1

· 2025

Full title: us-2025087302-a1

Year: 2025

Patent us-2025136705-a1

· 2025

Full title: us-2025136705-a1

Year: 2025

Patent us-2025101402-a1

· 2025

Full title: us-2025101402-a1

Year: 2025

Patent us-2025075172-a1

· 2025

Full title: us-2025075172-a1

Year: 2025

Patent us-2025059501-a1

· 2025

Full title: us-2025059501-a1

Year: 2025

Patent us-2025154229-a1

· 2025

Full title: us-2025154229-a1

Year: 2025

Patent us-2025101355-a1

· 2025

Full title: us-2025101355-a1

Year: 2025

Patent us-2025154470-a1

· 2025

Full title: us-2025154470-a1

Year: 2025

Patent us-2025145934-a1

· 2025

Full title: us-2025145934-a1

Year: 2025

Patent us-2025263770-a1

· 2025

Full title: us-2025263770-a1

Year: 2025

Patent us-2025326820-a1

· 2025

Full title: us-2025326820-a1

Year: 2025

Patent us-2025171732-a1

· 2025

Full title: us-2025171732-a1

Year: 2025

Patent us-4724206-a

· 1988

Full title: us-4724206-a

Year: 1988

Patent us-2025283068-a1

· 2025

Full title: us-2025283068-a1

Year: 2025

Patent us-5122469-a

· 1992

Full title: us-5122469-a

Year: 1992

Patent us-2011189734-a1

· 2011

Full title: us-2011189734-a1

Year: 2011

Patent us-2011117087-a1

· 2011

Full title: us-2011117087-a1

Year: 2011

Patent us-2012190068-a1

· 2012

Full title: us-2012190068-a1

Year: 2012

Patent us-2012231500-a1

· 2012

Full title: us-2012231500-a1

Year: 2012

Patent us-2012190061-a1

· 2012

Full title: us-2012190061-a1

Year: 2012

Patent us-2013017577-a1

· 2013

Full title: us-2013017577-a1

Year: 2013

Patent us-2012190005-a1

· 2012

Full title: us-2012190005-a1

Year: 2012

Patent us-2012129727-a1

· 2012

Full title: us-2012129727-a1

Year: 2012

Patent us-2013084593-a1

· 2013

Full title: us-2013084593-a1

Year: 2013

Patent us-2013102032-a1

· 2013

Full title: us-2013102032-a1

Year: 2013

Patent us-2013143238-a1

· 2013

Full title: us-2013143238-a1

Year: 2013

Patent us-2013149300-a1

· 2013

Full title: us-2013149300-a1

Year: 2013

Patent us-2014087424-a1

· 2014

Full title: us-2014087424-a1

Year: 2014

Patent us-2013266985-a1

· 2013

Full title: us-2013266985-a1

Year: 2013

Patent us-2013316434-a1

· 2013

Full title: us-2013316434-a1

Year: 2013

Patent us-2014038264-a1

· 2014

Full title: us-2014038264-a1

Year: 2014

Patent us-2014099711-a1

· 2014

Full title: us-2014099711-a1

Year: 2014

Patent us-2014106405-a1

· 2014

Full title: us-2014106405-a1

Year: 2014

Patent us-2014302581-a1

· 2014

Full title: us-2014302581-a1

Year: 2014

Patent us-2015044719-a1

· 2015

Full title: us-2015044719-a1

Year: 2015

Patent us-2015044769-a1

· 2015

Full title: us-2015044769-a1

Year: 2015

Patent us-2015299638-a1

· 2015

Full title: us-2015299638-a1

Year: 2015

Patent us-2014273095-a1

· 2014

Full title: us-2014273095-a1

Year: 2014

Patent us-2015140607-a1

· 2015

Full title: us-2015140607-a1

Year: 2015

Patent us-2015218509-a1

· 2015

Full title: us-2015218509-a1

Year: 2015

Patent us-2016237399-a1

· 2016

Full title: us-2016237399-a1

Year: 2016

Patent us-2016076002-a1

· 2016

Full title: us-2016076002-a1

Year: 2016

Patent us-2016185847-a1

· 2016

Full title: us-2016185847-a1

Year: 2016

Patent us-2016244726-a1

· 2016

Full title: us-2016244726-a1

Year: 2016

Patent us-2016289633-a1

· 2016

Full title: us-2016289633-a1

Year: 2016

Patent us-2016186228-a1

· 2016

Full title: us-2016186228-a1

Year: 2016

Patent us-2016108357-a1

· 2016

Full title: us-2016108357-a1

Year: 2016

Patent us-2016230204-a1

· 2016

Full title: us-2016230204-a1

Year: 2016

Patent us-2016312179-a1

· 2016

Full title: us-2016312179-a1

Year: 2016

Patent us-2017016043-a1

· 2017

Full title: us-2017016043-a1

Year: 2017

Patent us-2016244725-a1

· 2016

Full title: us-2016244725-a1

Year: 2016

Patent us-2016355572-a1

· 2016

Full title: us-2016355572-a1

Year: 2016

Patent us-2016304928-a1

· 2016

Full title: us-2016304928-a1

Year: 2016

Patent us-2017017891-a1

· 2017

Full title: us-2017017891-a1

Year: 2017

Patent us-2017009269-a1

· 2017

Full title: us-2017009269-a1

Year: 2017

Patent us-2017088873-a1

· 2017

Full title: us-2017088873-a1

Year: 2017

Patent us-2017051309-a1

· 2017

Full title: us-2017051309-a1

Year: 2017

Patent us-2017129937-a1

· 2017

Full title: us-2017129937-a1

Year: 2017

Patent us-10030064-b2

· 2018

Full title: us-10030064-b2

Year: 2018

Patent us-10119118-b2

· 2018

Full title: us-10119118-b2

Year: 2018

Patent us-10059754-b2

· 2018

Full title: us-10059754-b2

Year: 2018

Patent us-10118966-b2

· 2018

Full title: us-10118966-b2

Year: 2018

Patent us-10119117-b2

· 2018

Full title: us-10119117-b2

Year: 2018

Patent us-10233231-b2

· 2019

Full title: us-10233231-b2

Year: 2019

Patent us-10738334-b2

· 2020

Full title: us-10738334-b2

Year: 2020

Patent us-10196665-b2

· 2019

Full title: us-10196665-b2

Year: 2019

Patent us-10435464-b1

· 2019

Full title: us-10435464-b1

Year: 2019

Patent us-10590455-b2

· 2020

Full title: us-10590455-b2

Year: 2020

Patent us-10494421-b2

· 2019

Full title: us-10494421-b2

Year: 2019

Patent us-10676772-b2

· 2020

Full title: us-10676772-b2

Year: 2020

Patent us-10745672-b2

· 2020

Full title: us-10745672-b2

Year: 2020

Patent us-10501769-b2

· 2019

Full title: us-10501769-b2

Year: 2019

Patent us-10982003-b2

· 2021

Full title: us-10982003-b2

Year: 2021

Patent us-11014981-b2

· 2021

Full title: us-11014981-b2

Year: 2021

Patent us-10816477-b2

· 2020

Full title: us-10816477-b2

Year: 2020

Patent us-10961556-b2

· 2021

Full title: us-10961556-b2

Year: 2021

Patent us-10808272-b2

· 2020

Full title: us-10808272-b2

Year: 2020

Patent us-11021728-b2

· 2021

Full title: us-11021728-b2

Year: 2021

Patent us-11136610-b2

· 2021

Full title: us-11136610-b2

Year: 2021

Patent us-11377678-b2

· 2022

Full title: us-11377678-b2

Year: 2022

Patent us-10988761-b2

· 2021

Full title: us-10988761-b2

Year: 2021

Patent us-11377677-b2

· 2022

Full title: us-11377677-b2

Year: 2022

Patent us-11332771-b2

· 2022

Full title: us-11332771-b2

Year: 2022

Patent us-11104875-b2

· 2021

Full title: us-11104875-b2

Year: 2021

Patent us-11390663-b2

· 2022

Full title: us-11390663-b2

Year: 2022

Patent us-11390839-b2

· 2022

Full title: us-11390839-b2

Year: 2022

Patent us-11505784-b2

· 2022

Full title: us-11505784-b2

Year: 2022

Patent us-11292829-b2

· 2022

Full title: us-11292829-b2

Year: 2022

Patent us-11718864-b2

· 2023

Full title: us-11718864-b2

Year: 2023

Patent us-11396540-b1

· 2022

Full title: us-11396540-b1

Year: 2022

Patent us-11401509-b2

· 2022

Full title: us-11401509-b2

Year: 2022

Patent us-11254964-b1

· 2022

Full title: us-11254964-b1

Year: 2022

Patent us-11655457-b2

· 2023

Full title: us-11655457-b2

Year: 2023

Patent us-11702628-b2

· 2023

Full title: us-11702628-b2

Year: 2023

Patent us-11970724-b2

· 2024

Full title: us-11970724-b2

Year: 2024

Patent us-12103975-b2

· 2024

Full title: us-12103975-b2

Year: 2024

Patent us-12031151-b2

· 2024

Full title: us-12031151-b2

Year: 2024

Patent us-12195712-b2

· 2025

Full title: us-12195712-b2

Year: 2025

Patent us-12234483-b2

· 2025

Full title: us-12234483-b2

Year: 2025

Patent us-12331341-b2

· 2025

Full title: us-12331341-b2

Year: 2025

Patent us-12043845-b2

· 2024

Full title: us-12043845-b2

Year: 2024

Patent us-12163122-b2

· 2024

Full title: us-12163122-b2

Year: 2024

Patent us-12202906-b2

· 2025

Full title: us-12202906-b2

Year: 2025

Patent us-12286619-b2

· 2025

Full title: us-12286619-b2

Year: 2025

Patent us-12415980-b2

· 2025

Full title: us-12415980-b2

Year: 2025

Patent us-12351641-b2

· 2025

Full title: us-12351641-b2

Year: 2025

Patent us-12291563-b2

· 2025

Full title: us-12291563-b2

Year: 2025

Patent us-2002182208-a1

· 2002

Full title: us-2002182208-a1

Year: 2002

Patent us-2002019031-a1

· 2002

Full title: us-2002019031-a1

Year: 2002

Patent us-2003035799-a1

· 2003

Full title: us-2003035799-a1

Year: 2003

Patent us-12371656-b2

· 2025

Full title: us-12371656-b2

Year: 2025

Patent us-2002119530-a1

· 2002

Full title: us-2002119530-a1

Year: 2002

Patent us-2003235898-a1

· 2003

Full title: us-2003235898-a1

Year: 2003

Patent us-2004175798-a1

· 2004

Full title: us-2004175798-a1

Year: 2004

Patent us-2004048368-a1

· 2004

Full title: us-2004048368-a1

Year: 2004

Patent us-2003087372-a1

· 2003

Full title: us-2003087372-a1

Year: 2003

Patent us-2005272124-a1

· 2005

Full title: us-2005272124-a1

Year: 2005

Patent us-2005019859-a1

· 2005

Full title: us-2005019859-a1

Year: 2005

Patent us-2004137000-a1

· 2004

Full title: us-2004137000-a1

Year: 2004

Patent us-2005191697-a1

· 2005

Full title: us-2005191697-a1

Year: 2005

Patent us-2004228857-a1

· 2004

Full title: us-2004228857-a1

Year: 2004

Patent us-2004077086-a1

· 2004

Full title: us-2004077086-a1

Year: 2004

Patent us-2005070013-a1

· 2005

Full title: us-2005070013-a1

Year: 2005

Patent us-2006121444-a1

· 2006

Full title: us-2006121444-a1

Year: 2006

Patent us-2005221393-a1

· 2005

Full title: us-2005221393-a1

Year: 2005

Patent us-2005277132-a1

· 2005

Full title: us-2005277132-a1

Year: 2005

Patent us-2006121568-a1

· 2006

Full title: us-2006121568-a1

Year: 2006

Patent us-2006115901-a1

· 2006

Full title: us-2006115901-a1

Year: 2006

Patent us-2006121569-a1

· 2006

Full title: us-2006121569-a1

Year: 2006

Patent us-2006160180-a1

· 2006

Full title: us-2006160180-a1

Year: 2006

Patent us-2008108553-a1

· 2008

Full title: us-2008108553-a1

Year: 2008

Patent us-2008031873-a1

· 2008

Full title: us-2008031873-a1

Year: 2008

Patent us-2008131934-a1

· 2008

Full title: us-2008131934-a1

Year: 2008

Patent us-2008279852-a1

· 2008

Full title: us-2008279852-a1

Year: 2008

Patent us-2009023186-a1

· 2009

Full title: us-2009023186-a1

Year: 2009

Patent us-2009221003-a1

· 2009

Full title: us-2009221003-a1

Year: 2009

Patent us-2009042253-a1

· 2009

Full title: us-2009042253-a1

Year: 2009

Patent us-2010035342-a1

· 2010

Full title: us-2010035342-a1

Year: 2010

Patent us-2010086947-a1

· 2010

Full title: us-2010086947-a1

Year: 2010

Patent us-2010221781-a1

· 2010

Full title: us-2010221781-a1

Year: 2010

Patent us-2011081679-a1

· 2011

Full title: us-2011081679-a1

Year: 2011

Patent us-2011217772-a1

· 2011

Full title: us-2011217772-a1

Year: 2011

Patent us-2011086411-a1

· 2011

Full title: us-2011086411-a1

Year: 2011

Patent us-2011104734-a1

· 2011

Full title: us-2011104734-a1

Year: 2011

Patent us-2011250644-a1

· 2011

Full title: us-2011250644-a1

Year: 2011

Patent us-2012015438-a1

· 2012

Full title: us-2012015438-a1

Year: 2012

Patent us-5545405-a

· 1996

Full title: us-5545405-a

Year: 1996

Patent us-5316938-a

· 1994

Full title: us-5316938-a

Year: 1994

Patent us-5545404-a

· 1996

Full title: us-5545404-a

Year: 1996

Patent us-5633162-a

· 1997

Full title: us-5633162-a

Year: 1997

Patent us-5545403-a

· 1996

Full title: us-5545403-a

Year: 1996

Patent us-5856179-a

· 1999

Full title: us-5856179-a

Year: 1999

Patent us-5911989-a

· 1999

Full title: us-5911989-a

Year: 1999

Patent us-5672502-a

· 1997

Full title: us-5672502-a

Year: 1997

Patent us-6238891-b1

· 2001

Full title: us-6238891-b1

Year: 2001

Patent us-6180401-b1

· 2001

Full title: us-6180401-b1

Year: 2001

Patent us-6268484-b1

· 2001

Full title: us-6268484-b1

Year: 2001

Patent us-6905847-b2

· 2005

Full title: us-6905847-b2

Year: 2005

Patent us-7070960-b2

· 2006

Full title: us-7070960-b2

Year: 2006

Patent us-6458565-b1

· 2002

Full title: us-6458565-b1

Year: 2002

Patent us-7294484-b2

· 2007

Full title: us-7294484-b2

Year: 2007

Patent us-7429491-b2

· 2008

Full title: us-7429491-b2

Year: 2008

Patent us-7291484-b2

· 2007

Full title: us-7291484-b2

Year: 2007

Patent us-7541164-b2

· 2009

Full title: us-7541164-b2

Year: 2009

Patent us-7335491-b2

· 2008

Full title: us-7335491-b2

Year: 2008

Patent us-7569339-b2

· 2009

Full title: us-7569339-b2

Year: 2009

Patent us-7955833-b2

· 2011

Full title: us-7955833-b2

Year: 2011

Patent us-7300773-b2

· 2007

Full title: us-7300773-b2

Year: 2007

Patent us-8580554-b2

· 2013

Full title: us-8580554-b2

Year: 2013

Patent us-8399249-b2

· 2013

Full title: us-8399249-b2

Year: 2013

Patent us-8206981-b2

· 2012

Full title: us-8206981-b2

Year: 2012

Patent us-8232075-b2

· 2012

Full title: us-8232075-b2

Year: 2012

Patent us-8524497-b2

· 2013

Full title: us-8524497-b2

Year: 2013

Patent us-9068970-b2

· 2015

Full title: us-9068970-b2

Year: 2015

Patent us-8765415-b2

· 2014

Full title: us-8765415-b2

Year: 2014

Patent us-8986957-b2

· 2015

Full title: us-8986957-b2

Year: 2015

Patent us-8969043-b2

· 2015

Full title: us-8969043-b2

Year: 2015

Patent us-9163211-b2

· 2015

Full title: us-9163211-b2

Year: 2015

Patent us-9334489-b2

· 2016

Full title: us-9334489-b2

Year: 2016

Patent us-9260695-b2

· 2016

Full title: us-9260695-b2

Year: 2016

Patent us-9469865-b2

· 2016

Full title: us-9469865-b2

Year: 2016

Patent us-9340814-b2

· 2016

Full title: us-9340814-b2

Year: 2016

Patent us-9243224-b2

· 2016

Full title: us-9243224-b2

Year: 2016

Patent us-9540426-b2

· 2017

Full title: us-9540426-b2

Year: 2017

Patent us-2014329277-a1

· 2014

Full title: us-2014329277-a1

Year: 2014

Metadata only

Paper Glycoprotein (GP) Ib-IX-transfected Cells Roll on a von Willebrand Factor Matrix under Flow

Cranmer, Susan L.; Ulsemer, Philippe; Cooke, Brian M. et al. · 1999 · Journal of Biological Chemistry · DOI

Full title: Glycoprotein (GP) Ib-IX-transfected Cells Roll on a von Willebrand Factor Matrix under Flow

Authors: Cranmer, Susan L.; Ulsemer, Philippe; Cooke, Brian M.; Salem, Hatem H.; Salle, C de la; Lanza, François; Jackson, Shaun P.

Year: 1999

Venue: Journal of Biological Chemistry

DOI: https://doi.org/10.1074/jbc.274.10.6097

Paper Development of a novel mammalian display system for selection of antibodies against membrane proteins.

N. Robertson; Nancy López-Antón; S. Gurjar et al. · 2020 · Journal of Biological Chemistry · DOI

Full title: Development of a novel mammalian display system for selection of antibodies against membrane proteins.

Authors: N. Robertson; Nancy López-Antón; S. Gurjar; H. Khalique; Zainab Khalaf; Siobhan Clerkin; Vaughan R. Leydon; R. Parker-Manuel; A. Raeside; T. Payne; T. Jones; L. Seymour; R. Cawood

Year: 2020

Venue: Journal of Biological Chemistry

DOI: https://doi.org/10.1074/jbc.ra120.015053

Paper The use of site-specific recombination and cassette exchange technologies for monoclonal antibody production in Chinese Hamster ovary cells: retrospective analysis and future directions

Srirangan, Kajan; Loignon, Martin; Durocher, Yves · 2020 · Critical Reviews in Biotechnology · DOI

Full title: The use of site-specific recombination and cassette exchange technologies for monoclonal antibody production in Chinese Hamster ovary cells: retrospective analysis and future directions

Authors: Srirangan, Kajan; Loignon, Martin; Durocher, Yves

Year: 2020

Venue: Critical Reviews in Biotechnology

DOI: https://doi.org/10.1080/07388551.2020.1768043

Paper Ultrafast and high-throughput N-glycan analysis for monoclonal antibodies

Xiaoyu Yang; Sunnie Kim; Richard Ruzanski et al. · 2016 · mAbs · DOI

Full title: Ultrafast and high-throughput N-glycan analysis for monoclonal antibodies

Authors: Xiaoyu Yang; Sunnie Kim; Richard Ruzanski; Yuetian Chen; S. Moses; W. L. Ling; Xiaojuan Li; Shaoxiong Wang; Huijuan Li; A. Ambrogelly; Daisy Richardson; M. Shameem

Year: 2016

Venue: mAbs

DOI: https://doi.org/10.1080/19420862.2016.1156828

Paper Process intensification in fed-batch production bioreactors using non-perfusion seed cultures.

Yongky, Andrew; Xu, Jianlin; Tian, Jun et al. · 2019 · mAbs · DOI

Full title: Process intensification in fed-batch production bioreactors using non-perfusion seed cultures.

Authors: Yongky, Andrew; Xu, Jianlin; Tian, Jun; Oliveira, Christopher; Zhao, Jia; McFarland, Kevin; Borys, Michael C; Li, Zheng Jian

Year: 2019

Venue: mAbs

DOI: https://doi.org/10.1080/19420862.2019.1652075

Paper Enabling speed to clinic for monoclonal antibody programs using a pool of clones for IND-enabling toxicity studies.

Bolisetty, Parimala; Tremml, Gabi; Xu, Sen et al. · 2020 · mAbs · DOI

Full title: Enabling speed to clinic for monoclonal antibody programs using a pool of clones for IND-enabling toxicity studies.

Authors: Bolisetty, Parimala; Tremml, Gabi; Xu, Sen; Khetan, Anurag

Year: 2020

Venue: mAbs

DOI: https://doi.org/10.1080/19420862.2020.1763727

Paper A long non-coding SINEUP RNA boosts semi-stable production of fully human monoclonal antibodies in HEK293E cells

E. Sasso; D. Latino; G. Froechlich et al. · 2018 · mAbs · DOI

Full title: A long non-coding SINEUP RNA boosts semi-stable production of fully human monoclonal antibodies in HEK293E cells

Authors: E. Sasso; D. Latino; G. Froechlich; Mariangela Succoio; M. Passariello; C. De Lorenzo; A. Nicosia; N. Zambrano

Year: 2018

Venue: mAbs

DOI: https://doi.org/10.1080/19420862.2018.1463945

Paper High-throughput single-cell screening of viable hybridomas and patient-derived antibody-secreting cells using punchable microwells

Kaat Rubben; Ann-Sophie Vander Plaetsen; Ruben Almey et al. · 2024 · Artificial Cells Nanomedicine and Biotechnology · DOI

Full title: High-throughput single-cell screening of viable hybridomas and patient-derived antibody-secreting cells using punchable microwells

Authors: Kaat Rubben; Ann-Sophie Vander Plaetsen; Ruben Almey; O. Tytgat; Koen Deserranno; Jamie Debaere; Delphine Diana Acar; Philip Meuleman; D. Deforce; F. van Nieuwerburgh

Year: 2024

Venue: Artificial Cells Nanomedicine and Biotechnology

DOI: https://doi.org/10.1080/21691401.2024.2395815

Paper The Augmenting Effects of the tDNA Insulator on Stable Expression of Monoclonal Antibody in Chinese Hamster Ovary Cells.

Naderi, Fatemeh; Hashemi, Mehrdad; Bayat, Hadi et al. · 2018 · Monoclonal antibodies in immunodiagnosis and immunotherapy · DOI

Full title: The Augmenting Effects of the tDNA Insulator on Stable Expression of Monoclonal Antibody in Chinese Hamster Ovary Cells.

Authors: Naderi, Fatemeh; Hashemi, Mehrdad; Bayat, Hadi; Mohammadian, Omid; Pourmaleki, Es'hagh; Etemadzadeh, Mohammad Hossein; Rahimpour, Azam

Year: 2018

Venue: Monoclonal antibodies in immunodiagnosis and immunotherapy

DOI: https://doi.org/10.1089/mab.2018.0015

Paper Aggresomes: A Cellular Response to Misfolded Proteins

Johnston, Jennifer; Ward, Cristina L.; Kopito, Ron R. · 1998 · The Journal of Cell Biology · DOI

Full title: Aggresomes: A Cellular Response to Misfolded Proteins

Authors: Johnston, Jennifer; Ward, Cristina L.; Kopito, Ron R.

Year: 1998

Venue: The Journal of Cell Biology

DOI: https://doi.org/10.1083/jcb.143.7.1883

Paper Development of an Anti-Sheep Podoplanin Monoclonal Antibody PMab-256 for Immunohistochemical Analysis of Lymphatic Endothelial Cells

Y. Kato; Yoshikazu Furusawa; M. Sano et al. · 2020 · Monoclonal antibodies in immunodiagnosis and immunotherapy · DOI

Full title: Development of an Anti-Sheep Podoplanin Monoclonal Antibody PMab-256 for Immunohistochemical Analysis of Lymphatic Endothelial Cells

Authors: Y. Kato; Yoshikazu Furusawa; M. Sano; Junko Takei; Takuro Nakamura; Miyuki Yanaka; Saki Okamoto; Saori Handa; Yu Komatsu; Teizo Asano; Yusuke Sayama; M. Kaneko

Year: 2020

Venue: Monoclonal antibodies in immunodiagnosis and immunotherapy

DOI: https://doi.org/10.1089/mab.2020.0005

Paper Recombinant soluble human Fc gamma RII: production, characterization, and inhibition of the Arthus reaction.

Ierino, Frank; Powell, Maree S.; McKenzie, I F et al. · 1993 · The Journal of Experimental Medicine · DOI

Full title: Recombinant soluble human Fc gamma RII: production, characterization, and inhibition of the Arthus reaction.

Authors: Ierino, Frank; Powell, Maree S.; McKenzie, I F; Hogarth, P. Mark

Year: 1993

Venue: The Journal of Experimental Medicine

DOI: https://doi.org/10.1084/jem.178.5.1617

Paper Development of an Anti-Elephant Podoplanin Monoclonal Antibody PMab-265 for Flow Cytometry

Hideki Hosono; Teizo Asano; Junko Takei et al. · 2021 · Monoclonal antibodies in immunodiagnosis and immunotherapy · DOI

Full title: Development of an Anti-Elephant Podoplanin Monoclonal Antibody PMab-265 for Flow Cytometry

Authors: Hideki Hosono; Teizo Asano; Junko Takei; M. Sano; Tomohiro Tanaka; M. Kaneko; Y. Kato

Year: 2021

Venue: Monoclonal antibodies in immunodiagnosis and immunotherapy

DOI: https://doi.org/10.1089/mab.2021.0015

Paper Development of a Sensitive Anti-Mouse CCR5 Monoclonal Antibody for Flow Cytometry

Hiroyuki Suzuki; Tomohiro Tanaka; Guanjie Li et al. · 2024 · Monoclonal antibodies in immunodiagnosis and immunotherapy · DOI

Full title: Development of a Sensitive Anti-Mouse CCR5 Monoclonal Antibody for Flow Cytometry

Authors: Hiroyuki Suzuki; Tomohiro Tanaka; Guanjie Li; Tsunenori Ouchida; M. Kaneko; Y. Kato

Year: 2024

Venue: Monoclonal antibodies in immunodiagnosis and immunotherapy

DOI: https://doi.org/10.1089/mab.2024.0004

Paper Development of Anti-Mouse CC Chemokine Receptor 8 Monoclonal Antibodies for Flow Cytometry

Tomohiro Tanaka; Ren Nanamiya; Junko Takei et al. · 2021 · Monoclonal antibodies in immunodiagnosis and immunotherapy · DOI

Full title: Development of Anti-Mouse CC Chemokine Receptor 8 Monoclonal Antibodies for Flow Cytometry

Authors: Tomohiro Tanaka; Ren Nanamiya; Junko Takei; Takuro Nakamura; Miyuki Yanaka; Hideki Hosono; M. Sano; Teizo Asano; M. Kaneko; Y. Kato

Year: 2021

Venue: Monoclonal antibodies in immunodiagnosis and immunotherapy

DOI: https://doi.org/10.1089/mab.2021.0005

Paper Development and Characterization of Anti-Sheep Podoplanin Monoclonal Antibodies PMab-253 and PMab-260

M. Kaneko; M. Sano; Junko Takei et al. · 2020 · Monoclonal antibodies in immunodiagnosis and immunotherapy · DOI

Full title: Development and Characterization of Anti-Sheep Podoplanin Monoclonal Antibodies PMab-253 and PMab-260

Authors: M. Kaneko; M. Sano; Junko Takei; Teizo Asano; Yusuke Sayama; Hideki Hosono; Atsushi Kobayashi; S. Konnai; Y. Kato

Year: 2020

Venue: Monoclonal antibodies in immunodiagnosis and immunotherapy

DOI: https://doi.org/10.1089/mab.2020.0018

Paper Establishment of a Novel Anti-Mouse CCR1 Monoclonal Antibody C1Mab-6

Tsunenori Ouchida; Yumi Isoda; Takuro Nakamura et al. · 2024 · Monoclonal antibodies in immunodiagnosis and immunotherapy · DOI

Full title: Establishment of a Novel Anti-Mouse CCR1 Monoclonal Antibody C1Mab-6

Authors: Tsunenori Ouchida; Yumi Isoda; Takuro Nakamura; Miyuki Yanaka; Tomohiro Tanaka; Saori Handa; M. Kaneko; Hiroyuki Suzuki; Y. Kato

Year: 2024

Venue: Monoclonal antibodies in immunodiagnosis and immunotherapy

DOI: https://doi.org/10.1089/mab.2023.0032

Paper On enzymatic remodeling of IgG glycosylation; unique tools with broad applications

Sjögren, Jonathan; Lood, Rolf; Nägeli, Andreas · 2019 · Glycobiology · DOI

Full title: On enzymatic remodeling of IgG glycosylation; unique tools with broad applications

Authors: Sjögren, Jonathan; Lood, Rolf; Nägeli, Andreas

Year: 2019

Venue: Glycobiology

DOI: https://doi.org/10.1093/glycob/cwz085

Paper Understanding the role of antibody glycosylation through the lens of severe viral and bacterial diseases

Irvine, Edward B.; Alter, Galit · 2020 · Glycobiology · DOI

Full title: Understanding the role of antibody glycosylation through the lens of severe viral and bacterial diseases

Authors: Irvine, Edward B.; Alter, Galit

Year: 2020

Venue: Glycobiology

DOI: https://doi.org/10.1093/glycob/cwaa018

Paper Production of non-fucosylated antibodies by co-expression of heterologous GDP-6-deoxy-D-lyxo-4-hexulose reductase

Horsten, Hans Henning von; Ogorek, Christiane; Blanchard, Véronique et al. · 2010 · Glycobiology · DOI

Full title: Production of non-fucosylated antibodies by co-expression of heterologous GDP-6-deoxy-D-lyxo-4-hexulose reductase

Authors: Horsten, Hans Henning von; Ogorek, Christiane; Blanchard, Véronique; Demmler, C.D.; Giese, Christoph; Winkler, Karsten; Kaup, M.; Berger, Markus; Jordan, Ingo; Sandig, Volker

Year: 2010

Venue: Glycobiology

DOI: https://doi.org/10.1093/glycob/cwq109

Paper Identification of high affinity HER2 binding antibodies using CHO Fab surface display

Annalee W. Nguyen; Kevin C. Le; J. Maynard · 2018 · Protein engineering, design & selection : PEDS · DOI

Full title: Identification of high affinity HER2 binding antibodies using CHO Fab surface display

Authors: Annalee W. Nguyen; Kevin C. Le; J. Maynard

Year: 2018

Venue: Protein engineering, design & selection : PEDS

DOI: https://doi.org/10.1093/protein/gzy004

Paper A general method for the selection of high-level scFv and IgG antibody expression by stably transfected mammalian cells

Zuberbühler, Klaus; Palumbo, Alessandro; Bacci, Cristina et al. · 2008 · Protein Engineering Design and Selection · DOI

Full title: A general method for the selection of high-level scFv and IgG antibody expression by stably transfected mammalian cells

Authors: Zuberbühler, Klaus; Palumbo, Alessandro; Bacci, Cristina; Giovannoni, Leonardo; Sommavilla, Roberto; Kaspar, M.; Trachsel, Eveline; Neri, Dario

Year: 2008

Venue: Protein Engineering Design and Selection

DOI: https://doi.org/10.1093/protein/gzn068

Paper Heterologous protein production using euchromatin-containing expression vectors in mammalian cells

Zboray, Katalin; Sommeregger, Wolfgang; Bogner, Edith et al. · 2015 · Nucleic Acids Research · DOI

Full title: Heterologous protein production using euchromatin-containing expression vectors in mammalian cells

Authors: Zboray, Katalin; Sommeregger, Wolfgang; Bogner, Edith; Gili, Andreas; Sterovsky, Thomas; Fauland, Katharina; Grabner, Beatrice; Stiedl, Patricia; Moll, Herwig P.; Bauer, Anton; Kunert, Renate; Casanova, Emilio

Year: 2015

Venue: Nucleic Acids Research

DOI: https://doi.org/10.1093/nar/gkv475

Paper Fc glycans of therapeutic antibodies as critical quality attributes

Reusch, Dietmar; Tejada, Max L. · 2015 · Glycobiology · DOI

Full title: Fc glycans of therapeutic antibodies as critical quality attributes

Authors: Reusch, Dietmar; Tejada, Max L.

Year: 2015

Venue: Glycobiology

DOI: https://doi.org/10.1093/glycob/cwv065

Paper A Microfluidic Chip for Screening High-Producing Hybridomas at the Single-Cell Level

Wei Zhang; Ren Li; Zhiguo Fang et al. · 2019 · IEEE/LEOS International Conference on Optical MEMS · DOI

Full title: A Microfluidic Chip for Screening High-Producing Hybridomas at the Single-Cell Level

Authors: Wei Zhang; Ren Li; Zhiguo Fang; Zhi Y. Hu; Zewen Wei; Qin Li

Year: 2019

Venue: IEEE/LEOS International Conference on Optical MEMS

DOI: https://doi.org/10.1109/memsys.2019.8870728

Paper Expression of Antibody Fragments with a ControlledN-Glycosylation Pattern and Induction of Endoplasmic Reticulum-Derived Vesicles in Seeds of Arabidopsis

Loos, Andreas; Droogenbroeck, Bart Van; Hillmer, Stefan et al. · 2011 · PLANT PHYSIOLOGY · DOI

Full title: Expression of Antibody Fragments with a ControlledN-Glycosylation Pattern and Induction of Endoplasmic Reticulum-Derived Vesicles in Seeds of Arabidopsis

Authors: Loos, Andreas; Droogenbroeck, Bart Van; Hillmer, Stefan; Grass, Josephine; Pabst, Martin; Castilho, Alexandra; Kunert, Renate; Liang, Mifang; Arcalís, Elsa; Robinson, David G.; Depicker, Ann; Steinkellner, Herta

Year: 2011

Venue: PLANT PHYSIOLOGY

DOI: https://doi.org/10.1104/pp.110.171330

Paper Structural and biological properties of human recombinant myeloperoxidase produced by Chinese hamster ovary cell lines

Moguilevsky, Nicole; Garcia-Quintana, Lida; Jacquet, Alain et al. · 1991 · European Journal of Biochemistry · DOI

Full title: Structural and biological properties of human recombinant myeloperoxidase produced by Chinese hamster ovary cell lines

Authors: Moguilevsky, Nicole; Garcia-Quintana, Lida; Jacquet, Alain; Tournay, Christophe; Fabry, L.; Piérard, L; Bollen, Alex

Year: 1991

Venue: European Journal of Biochemistry

DOI: https://doi.org/10.1111/j.1432-1033.1991.tb15950.x

Paper From gene to harvest: insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants.

M. Sack; T. Rademacher; H. Spiegel et al. · 2015 · Plant Biotechnology Journal · DOI

Full title: From gene to harvest: insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants.

Authors: M. Sack; T. Rademacher; H. Spiegel; A. Boes; S. Hellwig; J. Drossard; E. Stoger; R. Fischer

Year: 2015

Venue: Plant Biotechnology Journal

DOI: https://doi.org/10.1111/pbi.12438

Paper Glycoengineering of Antibodies for Modulating Functions

Wang, Lai‐Xi; Tong, Xin; Li, Chao et al. · 2019 · Annual Review of Biochemistry · DOI

Full title: Glycoengineering of Antibodies for Modulating Functions

Authors: Wang, Lai‐Xi; Tong, Xin; Li, Chao; Giddens, John P.; Li, Tiezheng

Year: 2019

Venue: Annual Review of Biochemistry

DOI: https://doi.org/10.1146/annurev-biochem-062917-012911

Paper Aggregates, Crystals, Gels, and Amyloids: Intracellular and Extracellular Phenotypes at the Crossroads of Immunoglobulin Physicochemical Property and Cell Physiology

Hasegawa, Haruki · 2013 · International Journal of Cell Biology · DOI

Full title: Aggregates, Crystals, Gels, and Amyloids: Intracellular and Extracellular Phenotypes at the Crossroads of Immunoglobulin Physicochemical Property and Cell Physiology

Authors: Hasegawa, Haruki

Year: 2013

Venue: International Journal of Cell Biology

DOI: https://doi.org/10.1155/2013/604867

Paper Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications

Zhong, Xiaotian; Wright, Jill F. · 2013 · International Journal of Cell Biology · DOI

Full title: Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications

Authors: Zhong, Xiaotian; Wright, Jill F.

Year: 2013

Venue: International Journal of Cell Biology

DOI: https://doi.org/10.1155/2013/273086

Paper Early Implementation of QbD in Biopharmaceutical Development: A Practical Example

Zurdo, Jesús; Arnell, Andreas; Obrezanova, Olga et al. · 2015 · BioMed Research International · DOI

Full title: Early Implementation of QbD in Biopharmaceutical Development: A Practical Example

Authors: Zurdo, Jesús; Arnell, Andreas; Obrezanova, Olga; Smith, Noel; Cuesta, Ramón Gómez de la; Gallagher, Thomas R. A.; Michael, Rebecca; Stallwood, Yvette; Ekblad, Caroline; Abrahmsén, Lars; Höidén‐Guthenberg, Ingmarie

Year: 2015

Venue: BioMed Research International

DOI: https://doi.org/10.1155/2015/605427

Paper Biopharmaceutical Manufacturing: Historical Perspectives and Future Directions

Szkodny, Alana C.; Lee, Kelvin H. · 2022 · Annual Review of Chemical and Biomolecular Engineering · DOI

Full title: Biopharmaceutical Manufacturing: Historical Perspectives and Future Directions

Authors: Szkodny, Alana C.; Lee, Kelvin H.

Year: 2022

Venue: Annual Review of Chemical and Biomolecular Engineering

DOI: https://doi.org/10.1146/annurev-chembioeng-092220-125832

Paper Abstract 6742: High-affinity human IgG1 antibody against GUCY2C for ADC development: Identification, characterization, and efficacy

Yunxia Zheng; Xiafen Wu; Junxiang Jia et al. · 2025 · Cancer Research · DOI

Full title: Abstract 6742: High-affinity human IgG1 antibody against GUCY2C for ADC development: Identification, characterization, and efficacy

Authors: Yunxia Zheng; Xiafen Wu; Junxiang Jia; Huihui Guo; Xiangfei Kong; Gengxiang Zhao; Yuanyuan Huang; Hangbo Ye; Xiaolei Liu; Yi Luo; Xiaoqiang Xie; Xia Zhou; Lu Bai; Wenjun Li; Binbin Chen; Qingliang Yang; R. Zhao

Year: 2025

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2025-6742

Paper The EF‐1α promoter maintains high‐level transgene expression from episomal vectors in transfected CHO‐K1 cells

Wang, Xiao-Yin; Xu, Zhong-Jie; Tian, Zheng‐Wei et al. · 2017 · Journal of Cellular and Molecular Medicine · DOI

Full title: The EF‐1α promoter maintains high‐level transgene expression from episomal vectors in transfected CHO‐K1 cells

Authors: Wang, Xiao-Yin; Xu, Zhong-Jie; Tian, Zheng‐Wei; Zhang, Xi; Xu, Danhua; Li, Qin; Zhang, Junhe; Wang, Tianyun

Year: 2017

Venue: Journal of Cellular and Molecular Medicine

DOI: https://doi.org/10.1111/jcmm.13216

Paper Immunoassays for Affinity, Avidity and Competition: Methods to Evaluate Monoclonal (and Polyclonal) Antibodies Useful Assays in Development of New Antibodies, Better Understanding of Commercial Antibodies: Their Usefulness in Specific Aims of Research [SOP]

A. Antes · 2016 · DOI

Full title: Immunoassays for Affinity, Avidity and Competition: Methods to Evaluate Monoclonal (and Polyclonal) Antibodies Useful Assays in Development of New Antibodies, Better Understanding of Commercial Antibodies: Their Usefulness in Specific Aims of Research [SOP]

Authors: A. Antes

Year: 2016

DOI: https://doi.org/10.13052/ijts2246-8765.2016.001

Paper The Inhibition Site on Myelin-Associated Glycoprotein Is within Ig-Domain 5 and Is Distinct from the Sialic Acid Binding Site

Cao, Zixuan; Qiu, Jin; Domeniconi, Marco et al. · 2007 · Journal of Neuroscience · DOI

Full title: The Inhibition Site on Myelin-Associated Glycoprotein Is within Ig-Domain 5 and Is Distinct from the Sialic Acid Binding Site

Authors: Cao, Zixuan; Qiu, Jin; Domeniconi, Marco; Hou, Jianwei; Bryson, J. Barney; Mellado, Wilfredo; Filbin, Marie T.

Year: 2007

Venue: Journal of Neuroscience

DOI: https://doi.org/10.1523/jneurosci.2404-07.2007

Paper Development of transfection and high-producer screening protocols for the CHOK1SV cell system

M. Celina de la Cruz Edmonds; M. Tellers; Christine Chan et al. · 2006 · Molecular Biotechnology · DOI

Full title: Development of transfection and high-producer screening protocols for the CHOK1SV cell system

Authors: M. Celina de la Cruz Edmonds; M. Tellers; Christine Chan; P. Salmon; D. Robinson; J. Markusen

Year: 2006

Venue: Molecular Biotechnology

DOI: https://doi.org/10.1385/mb:34:2:179

Paper High-yield production of recombinant antibody fragments in HEK-293 cells using sodium butyrate.

J. Grünberg; K. Knogler; R. Waibel et al. · 2003 · BioTechniques · DOI

Full title: High-yield production of recombinant antibody fragments in HEK-293 cells using sodium butyrate.

Authors: J. Grünberg; K. Knogler; R. Waibel; I. Novak‐Hofer

Year: 2003

Venue: BioTechniques

DOI: https://doi.org/10.2144/03345st02

Paper Production systems for recombinant antibodies

Schirrmann, Thomas · 2008 · Frontiers in bioscience · DOI

Full title: Production systems for recombinant antibodies

Authors: Schirrmann, Thomas

Year: 2008

Venue: Frontiers in bioscience

DOI: https://doi.org/10.2741/3024

Paper WITHDRAWN

Sietaram, Devi; Kotidis, Pavlos; Rowland‐Jones, Ruth C. et al. · 2024 · DOI

Full title: WITHDRAWN

Authors: Sietaram, Devi; Kotidis, Pavlos; Rowland‐Jones, Ruth C.; Finka, Gary; Lapkin, Alexei A.

Year: 2024

DOI: https://doi.org/10.26434/chemrxiv-2024-26vzd

Paper Directed evolution methods for overcoming trade‐offs between protein activity and stability

Stimple, Samuel D.; Smith, Matthew D.; Tessier, Peter M. · 2019 · AIChE Journal · DOI

Full title: Directed evolution methods for overcoming trade‐offs between protein activity and stability

Authors: Stimple, Samuel D.; Smith, Matthew D.; Tessier, Peter M.

Year: 2019

Venue: AIChE Journal

DOI: https://doi.org/10.1002/aic.16814

Paper Label‐free live cell imaging by Confocal Raman Microscopy identifies CHO host and producer cell lines

Mateu, Batirtze Prats; Harreither, Eva; Schosserer, Markus et al. · 2016 · Biotechnology Journal · DOI

Full title: Label‐free live cell imaging by Confocal Raman Microscopy identifies CHO host and producer cell lines

Authors: Mateu, Batirtze Prats; Harreither, Eva; Schosserer, Markus; Puxbaum, Verena; Gludovacz, Elisabeth; Borth, Nicole; Gierlinger, Notburga; Grillari, Johannes

Year: 2016

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.201600037

Paper Predictive glycoengineering of biosimilars using a Markov chain glycosylation model

Spahn, Philipp N.; Hansen, Anders Holmgaard; Kol, Stefan et al. · 2016 · Biotechnology Journal · DOI

Full title: Predictive glycoengineering of biosimilars using a Markov chain glycosylation model

Authors: Spahn, Philipp N.; Hansen, Anders Holmgaard; Kol, Stefan; Voldborg, Björn G.; Lewis, Nathan E.

Year: 2016

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.201600489

Paper Enhanced Genome Editing Tools For Multi‐Gene Deletion Knock‐Out Approaches Using Paired CRISPR sgRNAs in CHO Cells

Schmieder, Valerie; Bydlinski, Nina; Strasser, Richard et al. · 2017 · Biotechnology Journal · DOI

Full title: Enhanced Genome Editing Tools For Multi‐Gene Deletion Knock‐Out Approaches Using Paired CRISPR sgRNAs in CHO Cells

Authors: Schmieder, Valerie; Bydlinski, Nina; Strasser, Richard; Baumann, Martina; Kildegaard, Helene Faustrup; Jadhav, Vaibhav; Borth, Nicole

Year: 2017

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.201700211

Paper Pichia pastoris secretes recombinant proteins less efficiently than Chinese hamster ovary cells but allows higher space‐time yields for less complex proteins

Maccani, Andreas; Landes, Nils; Stadlmayr, Gerhard et al. · 2014 · Biotechnology Journal · DOI

Full title: Pichia pastoris secretes recombinant proteins less efficiently than Chinese hamster ovary cells but allows higher space‐time yields for less complex proteins

Authors: Maccani, Andreas; Landes, Nils; Stadlmayr, Gerhard; Maresch, Daniel; Leitner, Christian; Maurer, Michael; Gasser, Brigitte; Ernst, Wolfgang; Kunert, Renate; Mattanovich, Diethard

Year: 2014

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.201300305

Paper Defining process design space for monoclonal antibody cell culture.

Abu-Absi, Susan Fugett; Yang, LiYing; Thompson, Patrick et al. · 2010 · Biotechnology and bioengineering · DOI

Full title: Defining process design space for monoclonal antibody cell culture.

Authors: Abu-Absi, Susan Fugett; Yang, LiYing; Thompson, Patrick; Jiang, Canping; Kandula, Sunitha; Schilling, Bernhard; Shukla, Abhinav A

Year: 2010

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.22764

Paper Use of the chicken lysozyme 5′ matrix attachment region to generate high producer CHO cell lines

Girod, Pierre‐Alain; Zahn‐Zabal, Monique; Mermod, Nicolas · 2005 · Biotechnology and Bioengineering · DOI

Full title: Use of the chicken lysozyme 5′ matrix attachment region to generate high producer CHO cell lines

Authors: Girod, Pierre‐Alain; Zahn‐Zabal, Monique; Mermod, Nicolas

Year: 2005

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.20563

Paper Leveraging Transfection Dose Streamlines the Establishment of a Chinese Hamster Ovary Cell Targeted Integration System

Tao Sun; Xin Zhou; Yu Zhang et al. · 2025 · Biotechnology Journal · DOI

Full title: Leveraging Transfection Dose Streamlines the Establishment of a Chinese Hamster Ovary Cell Targeted Integration System

Authors: Tao Sun; Xin Zhou; Yu Zhang; Nan Yan; Ding Huang; Kee Wee Tan; Sam Zhang; Hang Zhou; Fei Chen; Xiaoyue Chen

Year: 2025

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.70165

Paper A study of monoclonal antibody‐producing CHO cell lines: What makes a stable high producer?

Chusainow, Janet; Yang, Yuansheng; Yeo, Jessna H. M. et al. · 2008 · Biotechnology and Bioengineering · DOI

Full title: A study of monoclonal antibody‐producing CHO cell lines: What makes a stable high producer?

Authors: Chusainow, Janet; Yang, Yuansheng; Yeo, Jessna H. M.; Toh, Poh Choo; Asvadi, Parisa; Wong, Niki S.C.; Yap, Miranda G.S.

Year: 2008

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.22158

Paper Evaluation of “Difficult‐to‐Express” Monoclonal Antibodies in a CHO‐Based Hybrid Site‐Specific Integration System Under Industrially Relevant Conditions

Szkodny, Alana C.; Lee, Kelvin H. · 2025 · Biotechnology Journal · DOI

Full title: Evaluation of “Difficult‐to‐Express” Monoclonal Antibodies in a CHO‐Based Hybrid Site‐Specific Integration System Under Industrially Relevant Conditions

Authors: Szkodny, Alana C.; Lee, Kelvin H.

Year: 2025

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.70102

Paper Duplication of a chromosome 2 segment in production CHO cell lines correlates with age‐related growth improvement

Wei Wei; Laura Zielewicz; Lin Zhang · 2024 · Biotechnology Journal · DOI

Full title: Duplication of a chromosome 2 segment in production CHO cell lines correlates with age‐related growth improvement

Authors: Wei Wei; Laura Zielewicz; Lin Zhang

Year: 2024

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202300407

Paper Bioprocessing of Recombinant CHO-K1, CHO-DG44, and CHO-S: CHO Expression Hosts Favor Either mAb Production or Biomass Synthesis

Reinhart, David; Damjanovic, Lukas; Kaisermayer, Christian et al. · 2018 · Biotechnology Journal · DOI

Full title: Bioprocessing of Recombinant CHO-K1, CHO-DG44, and CHO-S: CHO Expression Hosts Favor Either mAb Production or Biomass Synthesis

Authors: Reinhart, David; Damjanovic, Lukas; Kaisermayer, Christian; Sommeregger, Wolfgang; Gili, Andreas; Gasselhuber, Bernhard; Castan, Andreas; Mayrhofer, Patrick; Grünwald‐Gruber, Clemens; Kunert, Renate

Year: 2018

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.201700686

Paper Engineering mammalian cell factories for improved recombinant monoclonal antibody production: lessons from nature?

Dinnis, Diane M.; James, David C. · 2005 · Biotechnology and Bioengineering · DOI

Full title: Engineering mammalian cell factories for improved recombinant monoclonal antibody production: lessons from nature?

Authors: Dinnis, Diane M.; James, David C.

Year: 2005

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.20499

Paper Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells

Berger, Audrey; Fourn, Valérie Le; Masternak, Jacqueline et al. · 2020 · Biotechnology and Bioengineering · DOI

Full title: Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells

Authors: Berger, Audrey; Fourn, Valérie Le; Masternak, Jacqueline; Regamey, Alexandre; Bodenmann, Iris; Girod, Pierre‐Alain; Mermod, Nicolas

Year: 2020

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27274

Paper Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time

Feichtinger, Julia; Hernández, Inmaculada; Fischer, Christoph et al. · 2016 · Biotechnology and Bioengineering · DOI

Full title: Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time

Authors: Feichtinger, Julia; Hernández, Inmaculada; Fischer, Christoph; Hanscho, Michael; Auer, Norbert; Hackl, Matthias; Jadhav, Vaibhav; Baumann, Martina; Krempl, Peter M.; Schmidl, Christian; Farlik, Matthias; Schuster, Michael; Merkel, Angelika; Sommer, Andreas; Heath, Simon; Rico, Daniel; Bock, Christoph; Thallinger, Gerhard; Borth, Nicole

Year: 2016

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.25990

Paper Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring

Jorgolli, Marsela; Nevill, Tanner; Winters, Aaron et al. · 2019 · Biotechnology and Bioengineering · DOI

Full title: Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring

Authors: Jorgolli, Marsela; Nevill, Tanner; Winters, Aaron; Chen, Irwin; Chong, Su Kong; Lin, Fen‐Fen; Mock, Marissa; Chen, Ching; Le, Kim; Tan, Christopher; Jess, Philip; Han, Xu; Hamburger, Agi; Stevens, Jennitte; Munro, Trent P.; Wu, Ming C.; Tagari, Philip; Miranda, Les P.

Year: 2019

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27024

Paper Rapid whole monoclonal antibody analysis by mass spectrometry: An ultra scale-down study of the effect of harvesting by centrifugation on the post-translational modification profile.

Reid, C Q; Tait, A; Baldascini, H et al. · 2010 · Biotechnology and bioengineering · DOI

Full title: Rapid whole monoclonal antibody analysis by mass spectrometry: An ultra scale-down study of the effect of harvesting by centrifugation on the post-translational modification profile.

Authors: Reid, C Q; Tait, A; Baldascini, H; Mohindra, A; Racher, A; Bilsborough, S; Smales, C M; Hoare, M

Year: 2010

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.22790

Paper Modulation and modeling of monoclonal antibody N‐linked glycosylation in mammalian cell perfusion reactors

Daniel J. Karst; Ernesto Scibona; E. Serra et al. · 2017 · Biotechnology and Bioengineering · DOI

Full title: Modulation and modeling of monoclonal antibody N‐linked glycosylation in mammalian cell perfusion reactors

Authors: Daniel J. Karst; Ernesto Scibona; E. Serra; Jean-Marc Bielser; J. Souquet; Matthieu Stettler; H. Broly; M. Šoóš; M. Morbidelli; T. Villiger

Year: 2017

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.26315

Paper Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells

Chevallier, Valentine; Andersen, Mikael Rørdam; Malphettes, Laetitia · 2019 · Biotechnology and Bioengineering · DOI

Full title: Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells

Authors: Chevallier, Valentine; Andersen, Mikael Rørdam; Malphettes, Laetitia

Year: 2019

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27247

Paper Self‐Driving Development of Perfusion Processes for Monoclonal Antibody Production

Claudio Müller; Thomas Vuillemin; Chethana Janardhana Gadiyar et al. · 2025 · bioRxiv · DOI

Full title: Self‐Driving Development of Perfusion Processes for Monoclonal Antibody Production

Authors: Claudio Müller; Thomas Vuillemin; Chethana Janardhana Gadiyar; Jean-Marc Bielser; J. Souquet; Alessandro Fagnani; M. Sokolov; Moritz von Stosch; F. Feidl; A. Butté; M. N. Cruz Bournazou

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1002/bit.70093

Paper Antibody expression stability in CHO clonally derived cell lines and their subclones: Role of methylation in phenotypic and epigenetic heterogeneity

Patel, Neha A.; Anderson, Colin R.; Terkildsen, Sarah E. et al. · 2018 · Biotechnology Progress · DOI

Full title: Antibody expression stability in CHO clonally derived cell lines and their subclones: Role of methylation in phenotypic and epigenetic heterogeneity

Authors: Patel, Neha A.; Anderson, Colin R.; Terkildsen, Sarah E.; Davis, Ray C.; Pack, Laura; Bhargava, Swapnil; Clarke, Howard R. G.

Year: 2018

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2655

Paper Assurance of monoclonality in one round of cloning through cell sorting for single cell deposition coupled with high resolution cell imaging

Evans, Krista; Albanetti, Thomas; Venkat, Raghavan et al. · 2015 · Biotechnology Progress · DOI

Full title: Assurance of monoclonality in one round of cloning through cell sorting for single cell deposition coupled with high resolution cell imaging

Authors: Evans, Krista; Albanetti, Thomas; Venkat, Raghavan; Schoner, Ronald G.; Savery, James; Miró-Quesada, Guillermo; Rajan, Bhargavi; Groves, Christopher J.

Year: 2015

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2145

Paper Insertion of core CpG island element into human CMV promoter for enhancing recombinant protein expression stability in CHO cells

Mariati; Yeo, Jessna H. M.; Koh, Esther Y. C. et al. · 2014 · Biotechnology Progress · DOI

Full title: Insertion of core CpG island element into human CMV promoter for enhancing recombinant protein expression stability in CHO cells

Authors: Mariati; Yeo, Jessna H. M.; Koh, Esther Y. C.; Ho, Steven C. L.; Yang, Yuansheng

Year: 2014

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.1919

Paper Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production

Henry, Matthew; MacDonald, M. A.; Orellana, Camila A. et al. · 2020 · Biotechnology and Bioengineering · DOI

Full title: Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production

Authors: Henry, Matthew; MacDonald, M. A.; Orellana, Camila A.; Gray, Peter P.; Gillard, Marianne; Baker, Kym; Nielsen, Lars K.; Marcellin, Esteban; Mahler, Stephen M.; Martínez, Verónica S.

Year: 2020

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27269

Paper Production and scale‐up of a monoclonal antibody against 17‐hydroxyprogesterone

G. K. Chua; B. Abdul-Rahman; Y. Chisti · 2013 · Biotechnology progress (Print) · DOI

Full title: Production and scale‐up of a monoclonal antibody against 17‐hydroxyprogesterone

Authors: G. K. Chua; B. Abdul-Rahman; Y. Chisti

Year: 2013

Venue: Biotechnology progress (Print)

DOI: https://doi.org/10.1002/btpr.1656

Paper Accelerating and de‐risking CMC development with transposon‐derived manufacturing cell lines

Rajendran, Sowmya; Balasubramanian, Sowmya; Webster, Lynn et al. · 2021 · Biotechnology and Bioengineering · DOI

Full title: Accelerating and de‐risking CMC development with transposon‐derived manufacturing cell lines

Authors: Rajendran, Sowmya; Balasubramanian, Sowmya; Webster, Lynn; Lee, Maggie; Vavilala, Divya Teja; Kulikov, N.V.; Choi, Jessica; Tang, Calvin; Hunter, Molly; Wang, Rebecca; Kaur, Harpreet; Karunakaran, Surya; Sitaraman, Varsha; Minshull, Jeremy; Boldog, Ferenc

Year: 2021

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27742

Paper Accelerating patient access to novel biologics using stable pool‐derived product for non‐clinical studies and single clone‐derived product for clinical studies

Munro, Trent P.; Le, Kim; Lê, Hương Giang et al. · 2017 · Biotechnology Progress · DOI

Full title: Accelerating patient access to novel biologics using stable pool‐derived product for non‐clinical studies and single clone‐derived product for clinical studies

Authors: Munro, Trent P.; Le, Kim; Lê, Hương Giang; Zhang, Lı; Stevens, Jennitte; Soice, Neil; Benchaar, Sabrina A.; Hong, Robert W.; Goudar, Chetan T.

Year: 2017

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2572

Paper Traces matter: Targeted optimization of monoclonal antibody N‐glycosylation based on/by implementing automated high‐throughput trace element screening

Sven Markert; S. Torkler; Katharina F. Hohmann et al. · 2020 · Biotechnology progress (Print) · DOI

Full title: Traces matter: Targeted optimization of monoclonal antibody N‐glycosylation based on/by implementing automated high‐throughput trace element screening

Authors: Sven Markert; S. Torkler; Katharina F. Hohmann; O. Popp

Year: 2020

Venue: Biotechnology progress (Print)

DOI: https://doi.org/10.1002/btpr.3042

Paper Scale-down model qualification of ambr® 250 high-throughput mini-bioreactor system for two commercial-scale mAb processes.

Manahan, Matthew; Nelson, Michael; Cacciatore, Jonathan J et al. · 2019 · Biotechnology progress · DOI

Full title: Scale-down model qualification of ambr® 250 high-throughput mini-bioreactor system for two commercial-scale mAb processes.

Authors: Manahan, Matthew; Nelson, Michael; Cacciatore, Jonathan J; Weng, Jessica; Xu, Sen; Pollard, Jennifer

Year: 2019

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2870

Paper Evolving trends in mAb production processes

Shukla, Abhinav; Wolfe, Leslie S.; Mostafa, Sigma S. et al. · 2017 · Bioengineering & Translational Medicine · DOI

Full title: Evolving trends in mAb production processes

Authors: Shukla, Abhinav; Wolfe, Leslie S.; Mostafa, Sigma S.; Norman, Carnley

Year: 2017

Venue: Bioengineering & Translational Medicine

DOI: https://doi.org/10.1002/btm2.10061

Paper Quick generation of R aman spectroscopy based in‐process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture

Berry, Brandon; Dobrowsky, Terrence M.; Timson, Rebecca C. et al. · 2015 · Biotechnology Progress · DOI

Full title: Quick generation of R aman spectroscopy based in‐process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture

Authors: Berry, Brandon; Dobrowsky, Terrence M.; Timson, Rebecca C.; Kshirsagar, Rashmi; Ryll, Thomas; Wiltberger, Kelly

Year: 2015

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2205

Paper N‐linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG

Berkel, Patrick H.C. van; Gerritsen, Jolanda; Perdok, Gerrard J. et al. · 2009 · Biotechnology Progress · DOI

Full title: N‐linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG

Authors: Berkel, Patrick H.C. van; Gerritsen, Jolanda; Perdok, Gerrard J.; Valbjørn, Jesper; Vink, Tom; Winkel, Jan G. J. van de; Parren, Paul W.H.I.

Year: 2009

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.92

Paper Characterization of phenotypic and genotypic diversity in subclones derived from a clonal cell line

Tharmalingam, Tharmala; Barkhordarian, Hedieh; Tejeda, Nicole et al. · 2018 · Biotechnology Progress · DOI

Full title: Characterization of phenotypic and genotypic diversity in subclones derived from a clonal cell line

Authors: Tharmalingam, Tharmala; Barkhordarian, Hedieh; Tejeda, Nicole; Daris, Kristi; Yaghmour, Sam; Yam, Pheng; Lu, Fang; Goudar, Chetan T.; Munro, Trent P.; Stevens, Jennitte

Year: 2018

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2666

Paper CHO cells adapted to hypothermic growth produce high yields of recombinant β‐interferon

Sunley, Kevin; Tharmalingam, Tharmala; Butler, Michael · 2008 · Biotechnology Progress · DOI

Full title: CHO cells adapted to hypothermic growth produce high yields of recombinant β‐interferon

Authors: Sunley, Kevin; Tharmalingam, Tharmala; Butler, Michael

Year: 2008

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.9

Paper Preclinical development of a molecular clamp‐stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

Watterson, Daniel; Wijesundara, Danushka K.; Modhiran, Naphak et al. · 2021 · Clinical & Translational Immunology · DOI

Full title: Preclinical development of a molecular clamp‐stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

Authors: Watterson, Daniel; Wijesundara, Danushka K.; Modhiran, Naphak; Mordant, Francesca L.; Li, Zheyi; Avumegah, Michael S.; McMillan, Christopher L. D.; Lackenby, Julia; Guilfoyle, Kate; Amerongen, Geert van; Stittelaar, Koert J.; Cheung, Stacey T. M.; Bibby, Summa; Daleris, Mallory; Hoger, Kym; Gillard, Marianne; Radunz, Eve; Jones, Martina L.; Hughes, Karen; Hughes, Benjamin; Goh, Justin B.; Edwards, David; Scoble, Judith A.; Pearce, Lesley A.; Kowalczyk, Lukasz; Phan, Tram; La, Mylinh; Lu, Louis; Pham, Tam; Zhou, Qi; Brockman, David A.; Morgan, Sherry J.; Lau, Cora; Tran, Mai H.; Tapley, Peter; Villalón‐Letelier, Fernando; Barnes, James; Young, Andrew; Jaberolansar, Noushin; Scott, Connor A. P.; Isaacs, Ariel; Amarilla, Alberto A.; Khromykh, Alexander A.; Brand, Judith MA van den; Reading, Patrick C.; Ranasinghe, Charani; Subbarao, Kanta; Munro, Trent P.; Young, Paul R.; Chappell, Keith J.

Year: 2021

Venue: Clinical & Translational Immunology

DOI: https://doi.org/10.1002/cti2.1269

Paper Automation and miniaturization: enabling tools for fast, high‐throughput process development in integrated continuous biomanufacturing

Silva, Tiago Castanheira; Eppink, Michel H. M.; Ottens, Marcel · 2021 · Journal of Chemical Technology & Biotechnology · DOI

Full title: Automation and miniaturization: enabling tools for fast, high‐throughput process development in integrated continuous biomanufacturing

Authors: Silva, Tiago Castanheira; Eppink, Michel H. M.; Ottens, Marcel

Year: 2021

Venue: Journal of Chemical Technology & Biotechnology

DOI: https://doi.org/10.1002/jctb.6792

Paper Application of a quality by design approach to the cell culture process of monoclonal antibody production, resulting in the establishment of a design space.

Nagashima, Hiroaki; Watari, Akiko; Shinoda, Yasuharu et al. · 2013 · Journal of pharmaceutical sciences · DOI

Full title: Application of a quality by design approach to the cell culture process of monoclonal antibody production, resulting in the establishment of a design space.

Authors: Nagashima, Hiroaki; Watari, Akiko; Shinoda, Yasuharu; Okamoto, Hiroshi; Takuma, Shinya

Year: 2013

Venue: Journal of pharmaceutical sciences

DOI: https://doi.org/10.1002/jps.23744

Paper Over‐expression of secreted proteins from mammalian cell lines

Dalton, Annamarie C.; Barton, William A. · 2014 · Protein Science · DOI

Full title: Over‐expression of secreted proteins from mammalian cell lines

Authors: Dalton, Annamarie C.; Barton, William A.

Year: 2014

Venue: Protein Science

DOI: https://doi.org/10.1002/pro.2439

Paper Genome Engineering of Hybridomas to Generate Stable Cell Lines for Antibody Expression.

Cristina Parola; Derek M. Mason; A. Zingg et al. · 2018 · Methods in molecular biology · DOI

Full title: Genome Engineering of Hybridomas to Generate Stable Cell Lines for Antibody Expression.

Authors: Cristina Parola; Derek M. Mason; A. Zingg; D. Neumeier; S. Reddy

Year: 2018

Venue: Methods in molecular biology

DOI: https://doi.org/10.1007/978-1-4939-8730-6_7

Paper FLUIDOT: A Modular Microfluidic Platform for Single‐Cell Study and Retrieval, with Applications in Drug Tolerance Screening and Antibody Mining

Jolien Breukers; Karen Ven; Caroline Struyfs et al. · 2023 · Small Methods · DOI

Full title: FLUIDOT: A Modular Microfluidic Platform for Single‐Cell Study and Retrieval, with Applications in Drug Tolerance Screening and Antibody Mining

Authors: Jolien Breukers; Karen Ven; Caroline Struyfs; Louanne Ampofo; Iene Rutten; M. Imbrechts; Francesca Pollet; Julie Van Lent; Winnie Kerstens; Sam Noppen; D. Schols; P. De Munter; H. Thibaut; K. Vanhoorelbeke; D. Spasić; Paul Declerck; B. Cammue; N. Geukens; K. Thevissen; J. Lammertyn

Year: 2023

Venue: Small Methods

DOI: https://doi.org/10.1002/smtd.202201477

Paper An IRES-Mediated Tricistronic Vector for Efficient Generation of Stable, High-Level Monoclonal Antibody Producing CHO DG44 Cell Lines

Yeo, Jessna H. M.; Mariati; Yang, Yuansheng · 2018 · Methods in molecular biology · DOI

Full title: An IRES-Mediated Tricistronic Vector for Efficient Generation of Stable, High-Level Monoclonal Antibody Producing CHO DG44 Cell Lines

Authors: Yeo, Jessna H. M.; Mariati; Yang, Yuansheng

Year: 2018

Venue: Methods in molecular biology

DOI: https://doi.org/10.1007/978-1-4939-8648-4_17

Paper Fast quantitative determination of monoclonal antibody in infusion bags using protein A nano liquid chromatography

C. André; Y. Guillaume · 2024 · Separation Science Plus · DOI

Full title: Fast quantitative determination of monoclonal antibody in infusion bags using protein A nano liquid chromatography

Authors: C. André; Y. Guillaume

Year: 2024

Venue: Separation Science Plus

DOI: https://doi.org/10.1002/sscp.202400050

Paper Animal‐cell culture media: History, characteristics, and current issues

Yao, Tatsuma; Asayama, Yuta · 2017 · Reproductive Medicine and Biology · DOI

Full title: Animal‐cell culture media: History, characteristics, and current issues

Authors: Yao, Tatsuma; Asayama, Yuta

Year: 2017

Venue: Reproductive Medicine and Biology

DOI: https://doi.org/10.1002/rmb2.12024

Paper Screening and subcloning of high producer transfectomas using semisolid media and automated colony picker.

S. Dharshanan; C. S. Hung · 2014 · Methods in molecular biology · DOI

Full title: Screening and subcloning of high producer transfectomas using semisolid media and automated colony picker.

Authors: S. Dharshanan; C. S. Hung

Year: 2014

Venue: Methods in molecular biology

DOI: https://doi.org/10.1007/978-1-62703-992-5_7

Paper Rapid construction of transgene-amplified CHO cell lines by cell cycle checkpoint engineering

K. Lee; Masayoshi Onitsuka; K. Honda et al. · 2013 · Applied Microbiology and Biotechnology · DOI

Full title: Rapid construction of transgene-amplified CHO cell lines by cell cycle checkpoint engineering

Authors: K. Lee; Masayoshi Onitsuka; K. Honda; H. Ohtake; T. Omasa

Year: 2013

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-013-4923-9

Paper Multiple reaction monitoring targeted LC-MS analysis of potential cell death marker proteins for increased bioprocess control.

Albrecht, Simone; Kaisermayer, Christian; Reinhart, David et al. · 2018 · Analytical and bioanalytical chemistry · DOI

Full title: Multiple reaction monitoring targeted LC-MS analysis of potential cell death marker proteins for increased bioprocess control.

Authors: Albrecht, Simone; Kaisermayer, Christian; Reinhart, David; Ambrose, Monica; Kunert, Renate; Lindeberg, Anna; Bones, Jonathan

Year: 2018

Venue: Analytical and bioanalytical chemistry

DOI: https://doi.org/10.1007/s00216-018-1029-3

Paper Methods for production of monoclonal antibodies with specificity for human lung cancer cells

J. Minna; F. Cuttitta; S. Rosen et al. · 1981 · In Vitro · DOI

Full title: Methods for production of monoclonal antibodies with specificity for human lung cancer cells

Authors: J. Minna; F. Cuttitta; S. Rosen; P. Bunn; D. Carney; A. Gazdar; S. Krasnow

Year: 1981

Venue: In Vitro

DOI: https://doi.org/10.1007/bf02618603

Paper Current state and recent advances in biopharmaceutical production in Escherichia coli, yeasts and mammalian cells

Berlec, Aleš; Štrukelj, Borut · 2013 · Journal of Industrial Microbiology & Biotechnology · DOI

Full title: Current state and recent advances in biopharmaceutical production in Escherichia coli, yeasts and mammalian cells

Authors: Berlec, Aleš; Štrukelj, Borut

Year: 2013

Venue: Journal of Industrial Microbiology & Biotechnology

DOI: https://doi.org/10.1007/s10295-013-1235-0

Paper Using cell engineering and omic tools for the improvement of cell culture processes

Kuystermans, Darrin; Krampe, Britta; Swiderek, Halina et al. · 2007 · Cytotechnology · DOI

Full title: Using cell engineering and omic tools for the improvement of cell culture processes

Authors: Kuystermans, Darrin; Krampe, Britta; Swiderek, Halina; Al‐Rubeai, Mohamed

Year: 2007

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-007-9055-6

Paper Establishment of a semi-continuous scale-down clone screening model for intensified perfusion culture

Tao Sun; Yu Zhang; Hengrui Liang et al. · 2024 · Biotechnology Letters · DOI

Full title: Establishment of a semi-continuous scale-down clone screening model for intensified perfusion culture

Authors: Tao Sun; Yu Zhang; Hengrui Liang; Wenjing Fang; Zichen Qian; Kee Wee Tan; Junjie Li; Xiang Zheng; Mingyue Fang; Hang Zhou; Weichang Zhou; Sam Zhang

Year: 2024

Venue: Biotechnology Letters

DOI: https://doi.org/10.1007/s10529-024-03512-0

Paper Repeated integration of antibody genes into a pre-selected chromosomal locus of CHO cells using an accumulative site-specific gene integration system

Kawabe, Yoshinori; Makitsubo, Hirokatsu; Kameyama, Yujiro et al. · 2011 · Cytotechnology · DOI

Full title: Repeated integration of antibody genes into a pre-selected chromosomal locus of CHO cells using an accumulative site-specific gene integration system

Authors: Kawabe, Yoshinori; Makitsubo, Hirokatsu; Kameyama, Yujiro; Huang, ShuoHao; Itô, Akira; Kamihira, Masamichi

Year: 2011

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-011-9397-y

Paper From Efficiency to Yield: Exploring Recent Advances in CHO Cell Line Development for Monoclonal Antibodies

Sarmishta Majumdar; Ranjeet Desai; Aakarsh Hans et al. · 2024 · Molecular Biotechnology · DOI

Full title: From Efficiency to Yield: Exploring Recent Advances in CHO Cell Line Development for Monoclonal Antibodies

Authors: Sarmishta Majumdar; Ranjeet Desai; Aakarsh Hans; P. Dandekar; R. Jain

Year: 2024

Venue: Molecular Biotechnology

DOI: https://doi.org/10.1007/s12033-024-01060-6

Paper Characterization of a monoclonal antibody cell culture production process using a quality by design approach.

Horvath, Brian; Mun, Melissa; Laird, Michael W · 2010 · Molecular biotechnology · DOI

Full title: Characterization of a monoclonal antibody cell culture production process using a quality by design approach.

Authors: Horvath, Brian; Mun, Melissa; Laird, Michael W

Year: 2010

Venue: Molecular biotechnology

DOI: https://doi.org/10.1007/s12033-010-9267-4

Paper Molecular and functional analysis of monoclonal antibodies in support of biologics development

Wang, Xin; An, Zhiqiang; Luo, Wenxin et al. · 2017 · Protein & Cell · DOI

Full title: Molecular and functional analysis of monoclonal antibodies in support of biologics development

Authors: Wang, Xin; An, Zhiqiang; Luo, Wenxin; Xia, Ningshao; Zhao, Qinjian

Year: 2017

Venue: Protein & Cell

DOI: https://doi.org/10.1007/s13238-017-0447-x

Paper Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy

Mimura, Yusuke; Katoh, Toshihiko; Saldova, Radka et al. · 2017 · Protein & Cell · DOI

Full title: Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy

Authors: Mimura, Yusuke; Katoh, Toshihiko; Saldova, Radka; O’Flaherty, Róisín; Izumi, Tomonori; Mimura‐Kimura, Yuka; Utsunomiya, Toshiaki; Mizukami, Yoichi; Yamamoto, Kenji; Matsumoto, Tsuneo; Rudd, Pauline M.

Year: 2017

Venue: Protein & Cell

DOI: https://doi.org/10.1007/s13238-017-0433-3

Paper Engineering Translation in Mammalian Cell Factories to Increase Protein Yield: The Unexpected Use of Long Non-Coding SINEUP RNAs

Zucchelli, S.; Patrucco, Laura; Persichetti, Francesca et al. · 2016 · Computational and Structural Biotechnology Journal · DOI

Full title: Engineering Translation in Mammalian Cell Factories to Increase Protein Yield: The Unexpected Use of Long Non-Coding SINEUP RNAs

Authors: Zucchelli, S.; Patrucco, Laura; Persichetti, Francesca; Gustincich, Stefano; Cotella, Diego

Year: 2016

Venue: Computational and Structural Biotechnology Journal

DOI: https://doi.org/10.1016/j.csbj.2016.10.004

Paper Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing

O’Flaherty, Róisín; Bergin, Adam; Flampouri, Evangelia et al. · 2020 · Biotechnology Advances · DOI

Full title: Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing

Authors: O’Flaherty, Róisín; Bergin, Adam; Flampouri, Evangelia; Mota, Letícia Martins; Obaidi, Ismael; Quigley, Andrew; Xie, Yongjing; Butler, Michael

Year: 2020

Venue: Biotechnology Advances

DOI: https://doi.org/10.1016/j.biotechadv.2020.107552

Paper Stability of single copy transgene expression in CHOK1 cells is affected by histone modifications but not by DNA methylation

Spencer, Shawal; Gugliotta, Agustina; Koenitzer, Jennifer et al. · 2014 · Journal of Biotechnology · DOI

Full title: Stability of single copy transgene expression in CHOK1 cells is affected by histone modifications but not by DNA methylation

Authors: Spencer, Shawal; Gugliotta, Agustina; Koenitzer, Jennifer; Häuser, H.; Wirth, Dagmar

Year: 2014

Venue: Journal of Biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2014.12.009

Paper Glycosylation of biosimilars: Recent advances in analytical characterization and clinical implications

Duivelshof, Bastiaan L.; Jiskoot, Wim; Beck, Alain et al. · 2019 · Analytica Chimica Acta · DOI

Full title: Glycosylation of biosimilars: Recent advances in analytical characterization and clinical implications

Authors: Duivelshof, Bastiaan L.; Jiskoot, Wim; Beck, Alain; Veuthey, Jean‐Luc; Guillarme, Davy; D’Atri, Valentina

Year: 2019

Venue: Analytica Chimica Acta

DOI: https://doi.org/10.1016/j.aca.2019.08.044

Paper Genetic glycoengineering in mammalian cells

Narimatsu, Yoshiki; Büll, Christian; Chen, Yen‐Hsi et al. · 2021 · Journal of Biological Chemistry · DOI

Full title: Genetic glycoengineering in mammalian cells

Authors: Narimatsu, Yoshiki; Büll, Christian; Chen, Yen‐Hsi; Wandall, Hans H.; Yang, Zhang; Clausen, Henrik

Year: 2021

Venue: Journal of Biological Chemistry

DOI: https://doi.org/10.1016/j.jbc.2021.100448

Paper A robust scale-down model development and process characterization for monoclonal antibody biomanufacturing using multivariate data analysis.

Han, Sung-Hyuk; Park, Seo-Young; Cha, Hyun-Myoung et al. · 2025 · Journal of biotechnology · DOI

Full title: A robust scale-down model development and process characterization for monoclonal antibody biomanufacturing using multivariate data analysis.

Authors: Han, Sung-Hyuk; Park, Seo-Young; Cha, Hyun-Myoung; Lee, Kwang-Bae; Lim, Jin-Hyuk; Lee, Dong-Yup

Year: 2025

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2025.02.007

Paper Investigating the metabolic load of monoclonal antibody production conveyed to an inducible CHO cell line using a transfer-rate online monitoring system.

Reyes, Sebastian-Juan; Lemire, Lucas; Durocher, Yves et al. · 2025 · Journal of biotechnology · DOI

Full title: Investigating the metabolic load of monoclonal antibody production conveyed to an inducible CHO cell line using a transfer-rate online monitoring system.

Authors: Reyes, Sebastian-Juan; Lemire, Lucas; Durocher, Yves; Voyer, Robert; Henry, Olivier; Pham, Phuong Lan

Year: 2025

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2025.01.008

Paper Beyond tyrosine feeding: A novel fed-batch cultivation strategy based on tyrosine metabolic engineering in recombinant CHO cells.

Cao, Lei; Zhao, Liang; Ye, Qian et al. · 2026 · Journal of biotechnology · DOI

Full title: Beyond tyrosine feeding: A novel fed-batch cultivation strategy based on tyrosine metabolic engineering in recombinant CHO cells.

Authors: Cao, Lei; Zhao, Liang; Ye, Qian; Tan, Wen-Song

Year: 2026

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2025.10.003

Paper A rapid method for simultaneous evaluation of free light chain content and aggregate content in culture media of Chinese hamster ovary cells expressing monoclonal antibodies for cell line screening.

Yoichi Ishii; M. Tsukahara; K. Wakamatsu · 2016 · Journal of Bioscience and Bioengineering · DOI

Full title: A rapid method for simultaneous evaluation of free light chain content and aggregate content in culture media of Chinese hamster ovary cells expressing monoclonal antibodies for cell line screening.

Authors: Yoichi Ishii; M. Tsukahara; K. Wakamatsu

Year: 2016

Venue: Journal of Bioscience and Bioengineering

DOI: https://doi.org/10.1016/j.jbiosc.2015.08.002

Paper Beyond viability: Advancing CHO cell culture process strategies to modulate host cell protein levels

Sahoo, Ansuman; Devenney, Kyle; Nicolas, Marcus-Allen et al. · 2024 · New Biotechnology · DOI

Full title: Beyond viability: Advancing CHO cell culture process strategies to modulate host cell protein levels

Authors: Sahoo, Ansuman; Devenney, Kyle; Nicolas, Marcus-Allen; Zill, Nicholas; Gupta, Balrina; Madabhushi, Sri Ranganayaki

Year: 2024

Venue: New Biotechnology

DOI: https://doi.org/10.1016/j.nbt.2024.10.003

Paper Mobile Affinity Selection Chromatography Analysis of Therapeutic Monoclonal Antibodies

Meena L Narsimhan; Jinhee Kim; Nathan A Morris et al. · 2023 · Analytical Chemistry · DOI

Full title: Mobile Affinity Selection Chromatography Analysis of Therapeutic Monoclonal Antibodies

Authors: Meena L Narsimhan; Jinhee Kim; Nathan A Morris; Mary A Bower; Harsha P Gunawardena; Eric Bowen; Fred E Regnier

Year: 2023

Venue: Analytical Chemistry

DOI: https://doi.org/10.1021/acs.analchem.3c02180

Paper Hemin-DNA Switch-Assisted Microfluidic Chemiluminescence Immunoimaging for Rapid and Quantitative Screening of Specific Hybridomas.

Wencheng Xiao; Hang Ao; Nilin Wu et al. · 2026 · Analytical Chemistry · DOI

Full title: Hemin-DNA Switch-Assisted Microfluidic Chemiluminescence Immunoimaging for Rapid and Quantitative Screening of Specific Hybridomas.

Authors: Wencheng Xiao; Hang Ao; Nilin Wu; Jun Sun; Wenrui Hu; Yunlong Chen; Jie Wu; Huangxian Ju

Year: 2026

Venue: Analytical Chemistry

DOI: https://doi.org/10.1021/acs.analchem.5c07461

Paper Optimized Split Zeocin Selection System Enhances Monoclonal Antibody Productivity and Reduces High Mannose Levels in CHO Cells.

Shen, Yang; Liu, Jinpin; Liu, Tongxin et al. · 2025 · ACS synthetic biology · DOI

Full title: Optimized Split Zeocin Selection System Enhances Monoclonal Antibody Productivity and Reduces High Mannose Levels in CHO Cells.

Authors: Shen, Yang; Liu, Jinpin; Liu, Tongxin; Gao, Rong; Lian, Dujuan; Yang, Shuli; Feng, Quan; Huang, Ding; Zhang, Yu; Chen, Xiaoyue; Zhou, Hang; Liao, Shanhui; Sun, Tao

Year: 2025

Venue: ACS synthetic biology

DOI: https://doi.org/10.1021/acssynbio.5c00533

Paper Rapid Quantification of Monoclonal Antibody Titer in Cell Culture Harvests by Antibody-Induced Z-ELP-E2 Nanoparticle Cross-Linking.

A. Swartz; Wilfred Chen · 2018 · Analytical Chemistry · DOI

Full title: Rapid Quantification of Monoclonal Antibody Titer in Cell Culture Harvests by Antibody-Induced Z-ELP-E2 Nanoparticle Cross-Linking.

Authors: A. Swartz; Wilfred Chen

Year: 2018

Venue: Analytical Chemistry

DOI: https://doi.org/10.1021/acs.analchem.8b04083

Paper Estimating Absolute Protein–Protein Binding Free Energies by a Super Learner Model

E. J. F. Chaves; João Sartori; Whendel M Santos et al. · 2025 · Journal of Chemical Information and Modeling · DOI

Full title: Estimating Absolute Protein–Protein Binding Free Energies by a Super Learner Model

Authors: E. J. F. Chaves; João Sartori; Whendel M Santos; Carlos H B Cruz; Emmanuel N Mhrous; Manassés F Nacimento-Filho; M. Ferraz; Roberto D. Lins

Year: 2025

Venue: Journal of Chemical Information and Modeling

DOI: https://doi.org/10.1021/acs.jcim.4c01641

Paper Regulated overexpression of the survival factor bcl-2 in CHO cells increases viable cell density in batch culture and decreases DNA release in extended fixed-bed cultivation

Fussenegger, Martin; Fassnacht, D.; Schwartz, Regine et al. · 2000 · Cytotechnology · DOI

Full title: Regulated overexpression of the survival factor bcl-2 in CHO cells increases viable cell density in batch culture and decreases DNA release in extended fixed-bed cultivation

Authors: Fussenegger, Martin; Fassnacht, D.; Schwartz, Regine; Zanghi, James A.; Graf, Michael; Bailey, James E.; Pörtner, Ralf

Year: 2000

Venue: Cytotechnology

DOI: https://doi.org/10.1023/a:1008168522385

Paper Automated High-Throughput Capillary Circular Dichroism and Intrinsic Fluorescence Spectroscopy for Rapid Determination of Protein Structure

Charles Moore-Kelly; J. Welsh; A. Rodger et al. · 2019 · Analytical Chemistry · DOI

Full title: Automated High-Throughput Capillary Circular Dichroism and Intrinsic Fluorescence Spectroscopy for Rapid Determination of Protein Structure

Authors: Charles Moore-Kelly; J. Welsh; A. Rodger; T. Dafforn; O. Thomas

Year: 2019

Venue: Analytical Chemistry

DOI: https://doi.org/10.1021/acs.analchem.9b03259

Paper The gel microdrop secretion assay: Identification of a low productivity subpopulation arising during the production of human antibody in CHO cells

Hammill, Linda; Welles, J L; Carson, Gerald · 2000 · Cytotechnology · DOI

Full title: The gel microdrop secretion assay: Identification of a low productivity subpopulation arising during the production of human antibody in CHO cells

Authors: Hammill, Linda; Welles, J L; Carson, Gerald

Year: 2000

Venue: Cytotechnology

DOI: https://doi.org/10.1023/a:1008186113245

Paper A single droplet dispensing system for high-throughput screening and reliable recovery of rare events.

Marian Weiss; Sadat Hasan; Robert Genth et al. · 2025 · Lab on a Chip · DOI

Full title: A single droplet dispensing system for high-throughput screening and reliable recovery of rare events.

Authors: Marian Weiss; Sadat Hasan; Robert Genth; Mohammad Mollah; Elea Robert; Alejandro Gil; Lars Hufnagel

Year: 2025

Venue: Lab on a Chip

DOI: https://doi.org/10.1039/d4lc00536h

Paper Simple piggyBac transposon-based mammalian cell expression system for inducible protein production

Li, Zhijie; Michael, Iacovos P.; Zhou, Dongxia et al. · 2013 · Proceedings of the National Academy of Sciences · DOI

Full title: Simple piggyBac transposon-based mammalian cell expression system for inducible protein production

Authors: Li, Zhijie; Michael, Iacovos P.; Zhou, Dongxia; Nagy, András; Rini, James M.

Year: 2013

Venue: Proceedings of the National Academy of Sciences

DOI: https://doi.org/10.1073/pnas.1218620110

Paper COMPREHENSIVE EVALUATION OF EXPRESSION PLATFORM: CHERRY PICKING THE ‘RIGHT’ TO ACCOMPLISH THE ‘BEST

S. Gaur; Kinjal Bhadresha; B. Patel et al. · 2020 · Towards Excellence · DOI

Full title: COMPREHENSIVE EVALUATION OF EXPRESSION PLATFORM: CHERRY PICKING THE ‘RIGHT’ TO ACCOMPLISH THE ‘BEST

Authors: S. Gaur; Kinjal Bhadresha; B. Patel; M. Saraf; R. Rawal

Year: 2020

Venue: Towards Excellence

DOI: https://doi.org/10.37867/te120516

Paper Recent Advances in the Development of Monoclonal Antibodies and Next-Generation Antibodies

Singh, Rohit; Chandley, Pankaj; Rohatgi, Soma · 2023 · ImmunoHorizons · DOI

Full title: Recent Advances in the Development of Monoclonal Antibodies and Next-Generation Antibodies

Authors: Singh, Rohit; Chandley, Pankaj; Rohatgi, Soma

Year: 2023

Venue: ImmunoHorizons

DOI: https://doi.org/10.4049/immunohorizons.2300102

Paper Microbubbles: A high-throughput platform for the sustained culture, characterization, and isolation of single cells based on morphology, cytokine production, and antibody secretion.

James Kobie; L. DeLouise; A. Scheinman · 2017 · Journal of Immunology · DOI

Full title: Microbubbles: A high-throughput platform for the sustained culture, characterization, and isolation of single cells based on morphology, cytokine production, and antibody secretion.

Authors: James Kobie; L. DeLouise; A. Scheinman

Year: 2017

Venue: Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.198.supp.81.1

Paper Recombinant Dimeric IgA Antibodies against the Epidermal Growth Factor Receptor Mediate Effective Tumor Cell Killing

Lohse, Stefan; Derer, Stefanie; Beyer, Thomas et al. · 2011 · The Journal of Immunology · DOI

Full title: Recombinant Dimeric IgA Antibodies against the Epidermal Growth Factor Receptor Mediate Effective Tumor Cell Killing

Authors: Lohse, Stefan; Derer, Stefanie; Beyer, Thomas; Klausz, Katja; Peipp, Matthias; Leusen, Jeanette H.W.; Winkel, Jan G. J. van de; Dechant, Michael; Valerius, Thomas

Year: 2011

Venue: The Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.1003082

Paper Development of autoimmune antibodies against human phospholipase A2 receptor and the application as diagnostic criteria for primary membranous nephropathy.

Shukun Wu; Yixing Zhai; Na Yang et al. · 2025 · Clinical Nephrology · DOI

Full title: Development of autoimmune antibodies against human phospholipase A2 receptor and the application as diagnostic criteria for primary membranous nephropathy.

Authors: Shukun Wu; Yixing Zhai; Na Yang; Zhou Zhou; Yingchun Huang; Li Yang; Bing Lai; Guisen Li

Year: 2025

Venue: Clinical Nephrology

DOI: https://doi.org/10.5414/cn111747

Paper Cell culture processes for monoclonal antibody production.

Li, Feng; Vijayasankaran, Natarajan; Shen, Amy Yijuan et al. · 2010 · mAbs · DOI

Full title: Cell culture processes for monoclonal antibody production.

Authors: Li, Feng; Vijayasankaran, Natarajan; Shen, Amy Yijuan; Kiss, Robert; Amanullah, Ashraf

Year: 2010

Venue: mAbs

DOI: https://doi.org/10.4161/mabs.2.5.12720

Paper Bioprocessing of mAb (Monoclonal Antibodies) using Chinese Hamster Ovary (CHO) Cells: A Review

Richelle Bertly Josefano; Aivyanca A; Charlivo Mikaichi Dungus et al. · 2023 · Indonesian Journal of Life Sciences · DOI

Full title: Bioprocessing of mAb (Monoclonal Antibodies) using Chinese Hamster Ovary (CHO) Cells: A Review

Authors: Richelle Bertly Josefano; Aivyanca A; Charlivo Mikaichi Dungus; Jason Jonathan Hamid; Katherine Katherine

Year: 2023

Venue: Indonesian Journal of Life Sciences

DOI: https://doi.org/10.54250/ijls.v5i01.162

Paper Control of Key Parameters in Developing Mammalian Production Clones

Kunert, Renate; Wolbank, Susanne; Chang, Martina et al. · 2004

Full title: Control of Key Parameters in Developing Mammalian Production Clones

Authors: Kunert, Renate; Wolbank, Susanne; Chang, Martina; Voglauer, Regina; Borth, Nicole; Katinger, Hermann

Year: 2004

Paper [Production of anti-recombinant human arrest defective 1 protein (hARD1) monoclonal antibodies for assaying human breast cancer tissues].

Min Yu; Zehua Wang; Junli Gong et al. · 2010 · Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Full title: [Production of anti-recombinant human arrest defective 1 protein (hARD1) monoclonal antibodies for assaying human breast cancer tissues].

Authors: Min Yu; Zehua Wang; Junli Gong; Mingxing Ma; Yang Jiao; Weiwei Huang; Q. Lü; Lin Li; Hui Yang; D. Tan

Year: 2010

Venue: Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Thesis Model-based analysis of N-glycosylation in Chinese hamster ovary cells

Krambeck, Frederick J.; Bennun, Sandra V; Andersen, Mikael Rørdam et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Model-based analysis of N-glycosylation in Chinese hamster ovary cells

Authors: Krambeck, Frederick J.; Bennun, Sandra V; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Betenbaugh, Michael J.

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b07b66c3-9b3c-42d5-8350-78cf6f0092cb

Thesis Early-Stage In Silico Flowsheet Analysis for a Monoclonal Antibody Platform

Kaiser, Johann; id_orcid 0000-0002-1383-6531; Babi, Deenesh K. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Early-Stage In Silico Flowsheet Analysis for a Monoclonal Antibody Platform

Authors: Kaiser, Johann; id_orcid 0000-0002-1383-6531; Babi, Deenesh K.; Pinelo, Manuel; id_orcid 0000-0002-3944-6144; Krühne, Ulrich; id_orcid 0000-0001-7774-7442

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c3fbbf6b-2d0e-43ac-9387-8537778ebc8f

Thesis CHO glyco-engineering using CRISPR/Cas9 multiplexing for protein production with homogeneous N-glycan profiles

Amann, Thomas; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787 et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: CHO glyco-engineering using CRISPR/Cas9 multiplexing for protein production with homogeneous N-glycan profiles

Authors: Amann, Thomas; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Pristovsek, Nusa; Singh, Ankita; Min Lee, Gyun; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c6d75303-ecfd-4e56-a505-e7c61e81da81

Thesis Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

Noh, Soo Min; Shin, Seunghyeon; Min Lee, Gyun · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

Authors: Noh, Soo Min; Shin, Seunghyeon; Min Lee, Gyun

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c3748c8e-d76f-40e3-8fcb-c291becc3057

Thesis An Online Compendium of CHO RNA-Seq Data Allows Identification of CHO Cell Line-specific Transcriptomic Signatures

Singh, Ankita; Kildegaard, Helene F.; Andersen, Mikael R. et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: An Online Compendium of CHO RNA-Seq Data Allows Identification of CHO Cell Line-specific Transcriptomic Signatures

Authors: Singh, Ankita; Kildegaard, Helene F.; Andersen, Mikael R.; id_orcid 0000-0003-4794-6808

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bf556aa7-6180-46f6-8a4f-dd827e2311ac

Thesis Evaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration

Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Kumar Ganesan, Saravana et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Evaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration

Authors: Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Kumar Ganesan, Saravana; Martínez-Monje, Iván; Grav, Lise M.; id_orcid 0000-0001-8042-7108; Lavado-García, Jesús; Nielsen, Lars K.

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c72a6084-3783-4f79-b07b-6c0d4b2e6fdb

Thesis Chemical Inhibition of Autophagy:Examining its Potential to Increase the Specific Productivity of Recombinant CHO Cell Lines

Baek, Eric; Lin Kim, Che; Gyeom Kim, Mi et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Chemical Inhibition of Autophagy:Examining its Potential to Increase the Specific Productivity of Recombinant CHO Cell Lines

Authors: Baek, Eric; Lin Kim, Che; Gyeom Kim, Mi; Lee, Jae Seong; Min Lee, Gyun

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b8b4c661-28e5-45a2-8a60-42f9cdea3745

Thesis Method of designing carbohydrates

Lewis, Nathan; Chiang, Wan-Tien; Liang, Chenguang · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Method of designing carbohydrates

Authors: Lewis, Nathan; Chiang, Wan-Tien; Liang, Chenguang

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ba83157b-c8c3-43b6-8fd5-c238aa8df054

Thesis Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions

Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions

Authors: Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup; Min Lee, Gyun

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d8293414-1d83-4cde-bd35-d5339a98b4f4

Thesis Predictive glycoengineering of biosimilars using a Markov chain glycosylation model

Spahn, Philipp N.; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787 et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Predictive glycoengineering of biosimilars using a Markov chain glycosylation model

Authors: Spahn, Philipp N.; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Voldborg, Bjørn Gunnar; id_orcid 0000-0002-7005-1642; Lewis, Nathan E.

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c81572eb-3d8b-4c44-b92d-952116fe851f

Thesis Identifying Drivers of Downstream Yield Variability Using Integrated Process Models: An Application to API Manufacturing

Overgaard, Tobias; Bertran, Maria Ona; Jørgensen, John Bagterp et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Identifying Drivers of Downstream Yield Variability Using Integrated Process Models: An Application to API Manufacturing

Authors: Overgaard, Tobias; Bertran, Maria Ona; Jørgensen, John Bagterp; id_orcid 0000-0001-9799-2808; Nielsen, Bo Friis; id_orcid 0000-0001-9146-9733

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c4296fd2-3123-42e0-8e21-f09af0e5990b

Thesis Multiplex secretome engineering enhances recombinant protein production and purity

Kol, Stefan; Ley, Daniel; Wulff, Tune et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Multiplex secretome engineering enhances recombinant protein production and purity

Authors: Kol, Stefan; Ley, Daniel; Wulff, Tune; Decker, Marianne; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Schoffelen, Sanne; id_orcid 0000-0003-2664-8561; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Jensen, Tanja Lyholm; Gutierrez, Jahir M.; Chiang, Austin W. T.; Masson, Helen O.; Palsson, Bernhard O.; id_orcid 0000-0003-2357-6785; Voldborg, Bjørn Gunnar; id_orcid 0000-0002-7005-1642; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Kildegaard, Helene Faustrup; Min Lee, Gyun; Lewis, Nathan E.

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c440cd45-e242-4b63-9b03-861ba7d54bf2

Thesis Bioprocess for testing engineered cho cell lines using single-use bioreactors

Decker, Marianne · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Bioprocess for testing engineered cho cell lines using single-use bioreactors

Authors: Decker, Marianne

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/dc4a0b9d-3f6c-410b-97ef-d0ede37e6c36

Thesis Targeted gene integration for improved production of therapeutic proteins in CHO cells

Sergeeva, Daria · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Targeted gene integration for improved production of therapeutic proteins in CHO cells

Authors: Sergeeva, Daria

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e5d1f7f4-51e8-4ccc-989e-2d60bf1b29d7

Thesis Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells

Hefzi, Hooman; id_orcid 0009-0003-4067-6224; Martínez-Monge, Iván et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells

Authors: Hefzi, Hooman; id_orcid 0009-0003-4067-6224; Martínez-Monge, Iván; Marin de Mas, Igor; Cowie, Nicholas Luke; Toledo, Alejandro Gomez; Noh, Soo Min; Karottki, Karen Julie la Cour; Decker, Marianne; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Camacho-Zaragoza, Jose Manuel; Kol, Stefan; Schoffelen, Sanne; id_orcid 0000-0003-2664-8561; Pristovšek, Nuša; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Miguez, Antonio A.; Bjørn, Sara Petersen; id_orcid 0000-0003-3341-6160; Brøndum, Karen Kathrine; Javidi, Elham Maria; Jensen, Kristian Lund; Stangl, Laura; Kreidl, Emanuel; Kallehauge, Thomas Beuchert; Ley, Daniel; Ménard, Patrice; Petersen, Helle Munck; Sukhova, Zulfiya; Bauer, Anton; Casanova, Emilio; Barron, Niall; Malmström, Johan; Nielsen, Lars K.; Lee, Gyun Min; Kildegaard, Helene Faustrup; Voldborg, Bjørn G.; id_orcid 0000-0002-7005-1642; Lewis, Nathan E.

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c14c0655-7eef-4331-a9a9-fb44dd376e02

Thesis Multi-omic profiling of EPO-producing CHO cell panel reveals metabolic adaptation to heterologous protein production

Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Multi-omic profiling of EPO-producing CHO cell panel reveals metabolic adaptation to heterologous protein production

Authors: Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael; Magdenoska, Olivera; Nielsen, Kristian Fog; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d87f41ff-ed91-4f7b-bc8e-f9f6e581ebcb

Thesis Engineering death resistance in CHO cells for improved perfusion culture

MacDonald, Michael A.; Nöbel, Matthias; Martínez, Verónica S. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Engineering death resistance in CHO cells for improved perfusion culture

Authors: MacDonald, Michael A.; Nöbel, Matthias; Martínez, Verónica S.; Baker, Kym; Shave, Evan; Gray, Peter P.; Mahler, Stephen; Munro, Trent; Nielsen, Lars K.; Marcellin, Esteban

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ce202b32-0a67-4570-a87a-ab0849f12696

Thesis Knockout of sialidase and pro-apoptotic genes in Chinese hamster ovary cells enables the production of recombinant human erythropoietin in fed-batch cultures

Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Knockout of sialidase and pro-apoptotic genes in Chinese hamster ovary cells enables the production of recombinant human erythropoietin in fed-batch cultures

Authors: Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kildegaard, Helene Faustrup; Lee, Gyun Min

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c9ed1093-409a-45e5-9e27-a66fbd8ce161

Thesis Mitigating Clonal Variation in Recombinant Mammalian Cell Lines

Lee, Jae Seong; Kildegaard, Helene Faustrup; Lewis, Nathan E et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Mitigating Clonal Variation in Recombinant Mammalian Cell Lines

Authors: Lee, Jae Seong; Kildegaard, Helene Faustrup; Lewis, Nathan E; Min Lee, Gyun

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e6ffd8f9-bc7e-4842-a4c6-d073cdd1aba6

Thesis Improving culture performance and antibody production in CHO cell culture processes by reducing the Warburg effect

Buchsteiner, Maria; Quek, Lake-Ee; Gray, Peter et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Improving culture performance and antibody production in CHO cell culture processes by reducing the Warburg effect

Authors: Buchsteiner, Maria; Quek, Lake-Ee; Gray, Peter; Nielsen, Lars K.

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f0e67f85-4820-447f-988a-01acc4454c93

Thesis Expanding the CRISPR Toolbox for Chinese Hamster Ovary Cell Line Engineering

Julie la Cour Karottki, Karen · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Expanding the CRISPR Toolbox for Chinese Hamster Ovary Cell Line Engineering

Authors: Julie la Cour Karottki, Karen

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d08e2c40-059b-4d60-af81-5dcae6b7155e

Thesis Proteomic Analysis of Chinese Hamster Ovary Cells

Baycin-Hizal, Deniz; Tabb, David L.; Chaerkady, Raghothama et al. · 2012 · Technical University of Denmark (DTU) · DOI

Full title: Proteomic Analysis of Chinese Hamster Ovary Cells

Authors: Baycin-Hizal, Deniz; Tabb, David L.; Chaerkady, Raghothama; Chen, Lily; Lewis, Nathan; Nagarajan, Harish; Sarkaria, Vishaldeep; Kumar, Amit; Wolozny, Daniel; Colao, Joe; Jacobson, Elena; Tian, Yuan; O’Meally, Robert N.; Krag, Sharon S.; Cole, Robert N.; Palsson, Bernhard; id_orcid 0000-0003-2357-6785; Zhang, Hui; Betenbaugh, Michael

Year: 2012

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ce35867c-d9a3-4f8a-83d1-381c8096ef40

Thesis Network Reconstruction and In Silico Metabolic Model of Chinese Hamster Ovary cells

Calmels, Cyrielle · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Network Reconstruction and In Silico Metabolic Model of Chinese Hamster Ovary cells

Authors: Calmels, Cyrielle

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e8e79519-7089-44aa-9964-6700b9af9251

Thesis Customizing amino acid metabolism of Pichia pastoris for recombinant protein production

Rußmayer, Hannes; Buchetics, Markus; Mattanovich, Matthias et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Customizing amino acid metabolism of Pichia pastoris for recombinant protein production

Authors: Rußmayer, Hannes; Buchetics, Markus; Mattanovich, Matthias; Neubauer, Stefan; Steiger, Matthias; Graf, Alexandra B.; Koellensperger, Gunda; Hann, Stephan; Sauer, Michael; Gasser, Brigitte; Mattanovich, Diethard

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e65f1561-1cd7-495e-8db2-b64cc656c938

Thesis Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion

Ley, Daniel; Pereira, Sara; Pedersen, Lasse Ebdrup et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion

Authors: Ley, Daniel; Pereira, Sara; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Hefzi, Hooman; Davy, Anne Mathilde; Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Wulff, Tune; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e6e02b2a-1da9-46ca-ab3f-71e6a95e52f8

Thesis Systems Glycoengineering: Integrated Analyses of Glycomics, Transcriptomics and Phenotypic Data Reveal Complex Cellular Response to Glycoengineering in CHO Cells

Chiang, Wan-Tien; Gazestani, Vahid H.; Bao, Bokan et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Systems Glycoengineering: Integrated Analyses of Glycomics, Transcriptomics and Phenotypic Data Reveal Complex Cellular Response to Glycoengineering in CHO Cells

Authors: Chiang, Wan-Tien; Gazestani, Vahid H.; Bao, Bokan; Liang, Chenguang; Sorrention, James T.; Kellman, Benjamin P; Ménard, Patrice; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Sukhova, Zulfiya; Petersen Bjørn, Sara; id_orcid 0000-0003-3341-6160; Brøndum, Karen Kathrine; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Yang, Zhang; Joshi, Hiren; Clausen, Henrik; Voldborg, Bjørn Gunnar; id_orcid 0000-0002-7005-1642; Lewis, Nathan E.

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/efa2b2f2-9e12-42e0-8bdc-61da320e021d

Thesis Application of CRISPR/Cas9 Genome Editing to Improve Recombinant Protein Production in CHO Cells

Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Julie la Cour Karottki, Karen et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Application of CRISPR/Cas9 Genome Editing to Improve Recombinant Protein Production in CHO Cells

Authors: Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Julie la Cour Karottki, Karen; Lee, Jae Seong; Kildegaard, Helene Faustrup

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/fd4bf523-2939-4567-94bf-52951b06175f

Thesis Design of Optimal CHO Protein N-glycosylation Profiles

Amann, Thomas · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Design of Optimal CHO Protein N-glycosylation Profiles

Authors: Amann, Thomas

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f56793d2-957c-4049-bb8d-1cb2253f60a3

Thesis Proteomics in Cell Culture: From Genomics to Combined ‘Omics for Cell Line Engineering and Bioprocess Development

Heffner, Kelley; Kaas, Christian Schrøder; Kumar, Amit et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Proteomics in Cell Culture: From Genomics to Combined ‘Omics for Cell Line Engineering and Bioprocess Development

Authors: Heffner, Kelley; Kaas, Christian Schrøder; Kumar, Amit; Baycin-Hizal, Deniz; Betenbaugh, Michael

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f3008eb3-73ff-43ea-8c16-e730fc63ed76

Thesis Modeling apoptosis resistance in CHO cells with CRISPR-mediated knockouts of Bak1, Bax, and Bok

MacDonald, Michael A.; Barry, Craig; Groves, Teddy et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Modeling apoptosis resistance in CHO cells with CRISPR-mediated knockouts of Bak1, Bax, and Bok

Authors: MacDonald, Michael A.; Barry, Craig; Groves, Teddy; Martínez, Verónica S.; Gray, Peter P.; Baker, Kym; Shave, Evan; Mahler, Stephen; Munro, Trent; Marcellin, Esteban; Nielsen, Lars K.

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f471d371-7ef9-48ac-ad01-8f0de141966f

Thesis MODEL COMPARISON TO DESCRIBE BHK-21 CELL GROWTH AND METABOLISM IN STIRRED TANK BIOREACTORS OPERATED IN BATCH MODE

Sartori, Roger [UNESP]; Leme, Jaci; Caricati, Celso Pereira et al. · 2019 · Universidade Estadual Paulista (UNESP) · DOI

Full title: MODEL COMPARISON TO DESCRIBE BHK-21 CELL GROWTH AND METABOLISM IN STIRRED TANK BIOREACTORS OPERATED IN BATCH MODE

Authors: Sartori, Roger [UNESP]; Leme, Jaci; Caricati, Celso Pereira; Tonso, Aldo; Fernandez Nunez, Eutimio Gustavo [UNESP]

Year: 2019

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1590/0104-6632.20180352s20160592

Thesis Exploring the diversity and productivity of clonal Chinese hamster ovary host cell lines derived from a non-clonal population

Jeavons, Andrew · 2016 · University of Manchester · DOI

Full title: Exploring the diversity and productivity of clonal Chinese hamster ovary host cell lines derived from a non-clonal population

Authors: Jeavons, Andrew

Year: 2016

Venue: University of Manchester

DOI: https://research.manchester.ac.uk/en/studentTheses/512a4667-4a93-40ea-9a81-6b5b961e10e9

Thesis Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells

Chevallier, Valentine; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808 et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells

Authors: Chevallier, Valentine; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Malphettes, Laetitia

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ff089eb9-bd04-4d58-a66a-ada79e4b6341

Thesis Optimizing the glycosylation of recombinant proteins

Rosenlöcher, Julia · 2016 · Freie Universität Berlin (Refubium) · DOI

Full title: Optimizing the glycosylation of recombinant proteins

Authors: Rosenlöcher, Julia

Year: 2016

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/4198

Thesis Investigation of the role of the mTORC1 signalling pathway in growth and productivity of industrially-relevant GS-CHO cells

Dadehbeigi, Nazanin · 2012 · University of Manchester · DOI

Full title: Investigation of the role of the mTORC1 signalling pathway in growth and productivity of industrially-relevant GS-CHO cells

Authors: Dadehbeigi, Nazanin

Year: 2012

Venue: University of Manchester

DOI: https://research.manchester.ac.uk/en/studentTheses/b7820f57-2023-4667-830d-53ce1fe7eb76

Thesis A Streamlined Multivariate Analysis Platform for Optimizing Mammalian Cell Culture and Biologics Production

Mingee, Andrew Nicholas · 2021 · Georgia Institute of Technology · DOI

Full title: A Streamlined Multivariate Analysis Platform for Optimizing Mammalian Cell Culture and Biologics Production

Authors: Mingee, Andrew Nicholas

Year: 2021

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/65145

Thesis DROSOPHILA S2 cell culture in a WAVE Bioreactor: potential for scaling up the production of the recombinant rabies virus glycoprotein

Decarli, Monize Caiado; Santos, Diogo Peres dos; Astray, Renato Mancini et al. · 2018 · Universidade Estadual Paulista (UNESP) · DOI

Full title: DROSOPHILA S2 cell culture in a WAVE Bioreactor: potential for scaling up the production of the recombinant rabies virus glycoprotein

Authors: Decarli, Monize Caiado; Santos, Diogo Peres dos; Astray, Renato Mancini; Ventini-Monteiro, Daniella Cristina; Calil Jorge, Soraia Attie; Correia, Daniela Matilde; Silva, Juliana de Sa da; Rocca, Mayra Pereira [UNESP]; Langoni, Helio [UNESP]; Menozzi, Benedito Donizete [UNESP]; Pereira, Carlos Augusto; Torres Suazo, Claudio Alberto

Year: 2018

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1007/s00253-018-8962-0

Thesis Amino acid metabolism during batch culture of a murine hybridoma, AFP- 27

Barford, John Patrick; Marquis, Christopher Peter; Harbour, Colin · 1996 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Amino acid metabolism during batch culture of a murine hybridoma, AFP- 27

Authors: Barford, John Patrick; Marquis, Christopher Peter; Harbour, Colin

Year: 1996

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68870

Thesis The Effect of Heterofunctional Microparticles on Identifying High Producing CHO cells

Aurelio, Caroline · 2022 · Georgia Institute of Technology · DOI

Full title: The Effect of Heterofunctional Microparticles on Identifying High Producing CHO cells

Authors: Aurelio, Caroline

Year: 2022

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/66272

Thesis The Dynamic Sampling Platform (DSP) for Real-time Bioreactor Monitoring

Chilmonczyk, Mason A. · 2021 · Georgia Institute of Technology · DOI

Full title: The Dynamic Sampling Platform (DSP) for Real-time Bioreactor Monitoring

Authors: Chilmonczyk, Mason A.

Year: 2021

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/64969

Thesis Effect of Feed Rate on Growth Rate and Antibody Production in the Fed-batch Culture of Murine Hybridoma Cells

Jang, JD; Barford, JP · 2000 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Effect of Feed Rate on Growth Rate and Antibody Production in the Fed-batch Culture of Murine Hybridoma Cells

Authors: Jang, JD; Barford, JP

Year: 2000

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-24332

Thesis Biosynthesis of protein products by animal cells. Are growth and non- growth associated concepts valid or useful?

Barford, John Patrick; Phillips, Peter J.; Marquis, Christopher Peter et al. · 1996 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Biosynthesis of protein products by animal cells. Are growth and non- growth associated concepts valid or useful?

Authors: Barford, John Patrick; Phillips, Peter J.; Marquis, Christopher Peter; Harbour, Colin

Year: 1996

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68868

Thesis Methods and strategies available for the process control and optimization of monoclonal antibody production

Barford, John Patrick; Fu Pengcheng, · 1994 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Methods and strategies available for the process control and optimization of monoclonal antibody production

Authors: Barford, John Patrick; Fu Pengcheng,

Year: 1994

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68893

Thesis An Unstructured Kinetic Model of Macromolecular Metabolism in Batch and Fed-batch Cultures of Hybridoma Cells Producing Monoclonal Antibody

Jang, DJ; Barford, JP · 2000 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: An Unstructured Kinetic Model of Macromolecular Metabolism in Batch and Fed-batch Cultures of Hybridoma Cells Producing Monoclonal Antibody

Authors: Jang, DJ; Barford, JP

Year: 2000

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-28049

Thesis Evaluation of the batch kinetics of the amino acid metabolism of a mouse hybridoma and human lymphoblastoid cell line using a pre-column FDNDEA derivitisation, HPLC technique

Marquis, Christopher Peter; Barford, John Patrick; Harbour, Colin et al. · 1996 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Evaluation of the batch kinetics of the amino acid metabolism of a mouse hybridoma and human lymphoblastoid cell line using a pre-column FDNDEA derivitisation, HPLC technique

Authors: Marquis, Christopher Peter; Barford, John Patrick; Harbour, Colin; Nobbs, Denis M.

Year: 1996

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68904

Thesis Carbohydrate and amino acid metabolism during batch culture of a human lymphoblastoid cell line, BTSN6

Barford, John Patrick; Marquis, Christopher Peter; Harbour, Colin et al. · 1996 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Carbohydrate and amino acid metabolism during batch culture of a human lymphoblastoid cell line, BTSN6

Authors: Barford, John Patrick; Marquis, Christopher Peter; Harbour, Colin; Fletcher, Anne

Year: 1996

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68873

Thesis An analysis of some batch and continuous kinetic data of specific monoclonal antibodt production from hybridomas

Barford, John Patrick; Phillips, Peter J.; Marquis, Christopher Peter et al. · 1991 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: An analysis of some batch and continuous kinetic data of specific monoclonal antibodt production from hybridomas

Authors: Barford, John Patrick; Phillips, Peter J.; Marquis, Christopher Peter; Harbour, Colin

Year: 1991

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68958

Thesis The use of biosensors in control of fed-batch processes - Opportunities and limitations

Renneberg, R.; Barford, JP; Tse, SMA · 1998 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: The use of biosensors in control of fed-batch processes - Opportunities and limitations

Authors: Renneberg, R.; Barford, JP; Tse, SMA

Year: 1998

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-44080

Thesis Simulation and dynamic optimisation of animal cell culture

Barford, John Patrick; Sanderson, Charles S.; Barton, Geoffrey W. · 1997 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Simulation and dynamic optimisation of animal cell culture

Authors: Barford, John Patrick; Sanderson, Charles S.; Barton, Geoffrey W.

Year: 1997

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68866

Thesis Optimisation of animal cell culture media using dynamic simulation

Barford, John Patrick; Sanderson, Charles S.; Barton, Geoffrey W. · 1995 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Optimisation of animal cell culture media using dynamic simulation

Authors: Barford, John Patrick; Sanderson, Charles S.; Barton, Geoffrey W.

Year: 1995

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68885

Thesis A comparison of different culture methods for hybridoma propagation and monoclonal antibody production

Barford, John Patrick; Marquis, Christopher Peter; Harbour, Colin et al. · 1990 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: A comparison of different culture methods for hybridoma propagation and monoclonal antibody production

Authors: Barford, John Patrick; Marquis, Christopher Peter; Harbour, Colin; Löw, K.S.

Year: 1990

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68971

Thesis CHOGlycoNET: comprehensive glycosylation reaction network for CHO cells

Kotidis, Pavlos; Donini, Roberto; Arnsdorf, Johnny et al. · 2023 · Imperial College London · DOI

Full title: CHOGlycoNET: comprehensive glycosylation reaction network for CHO cells

Authors: Kotidis, Pavlos; Donini, Roberto; Arnsdorf, Johnny; Hansen, Anders Holmgaard; Voldborg, Bjorn Gunnar Rude; Chiang, Austin WT; Haslam, Stuart M; Betenbaugh, Michael; del Val, Ioscani Jimenez; Lewis, Nathan E; Krambeck, Frederick; Kontoravdi, Cleo

Year: 2023

Venue: Imperial College London

DOI: https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000927440500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Genome-Based Metabolic Modelling of CHO Cells

Chen, Ning · 2013 · Imperial College London · DOI

Full title: Genome-Based Metabolic Modelling of CHO Cells

Authors: Chen, Ning

Year: 2013

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/11054

Thesis Enhanced understanding of protein glycosylation in CHO cells through computational tools and experimentation

Kotidis, Pavlos · 2022 · Imperial College London · DOI

Full title: Enhanced understanding of protein glycosylation in CHO cells through computational tools and experimentation

Authors: Kotidis, Pavlos

Year: 2022

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/100281

Thesis Towards advanced bioprocess optimization: a multiscale modelling approach

Monteiro, Mariana; Fadda, Sarah; Kontoravdi, Kleio · 2023 · Imperial College London · DOI

Full title: Towards advanced bioprocess optimization: a multiscale modelling approach

Authors: Monteiro, Mariana; Fadda, Sarah; Kontoravdi, Kleio

Year: 2023

Venue: Imperial College London

DOI: https://www.sciencedirect.com/science/article/pii/S2001037023002362

Thesis Utilising a genome scale metabolic model to design high-producing CHO cell lines through bi-level optimisation

Antonakoudis, Athanasios · 2024 · Imperial College London · DOI

Full title: Utilising a genome scale metabolic model to design high-producing CHO cell lines through bi-level optimisation

Authors: Antonakoudis, Athanasios

Year: 2024

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/110783

Thesis Systematic development of predictive mathematical models for animal cell cultures

Kontoravdi, Cleo; Pistikopoulos, Efstratios N; Mantalaris, Athanasios · 2014 · Imperial College London · DOI

Full title: Systematic development of predictive mathematical models for animal cell cultures

Authors: Kontoravdi, Cleo; Pistikopoulos, Efstratios N; Mantalaris, Athanasios

Year: 2014

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000279658700003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Effect of Chinese hamster ovary culture PH on sialylation and antibody productivity

McIntosh, Calum John · 2024 · Imperial College London · DOI

Full title: Effect of Chinese hamster ovary culture PH on sialylation and antibody productivity

Authors: McIntosh, Calum John

Year: 2024

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/110593

Thesis Development of hybrid platforms for antibody manufacturing optimisation

Barbosa, Rodrigo · 2024 · Imperial College London · DOI

Full title: Development of hybrid platforms for antibody manufacturing optimisation

Authors: Barbosa, Rodrigo

Year: 2024

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/110760

Thesis How reliable are Chinese hamster ovary (CHO) cell genome-scale metabolic models?

Strain, Benjamin; Morrissey, richard; Antonakoudis, Athanasios et al. · 2023 · Imperial College London · DOI

Full title: How reliable are Chinese hamster ovary (CHO) cell genome-scale metabolic models?

Authors: Strain, Benjamin; Morrissey, richard; Antonakoudis, Athanasios; Kontoravdi, Kleio

Year: 2023

Venue: Imperial College London

DOI: https://onlinelibrary.wiley.com/doi/full/10.1002/bit.28366

Thesis Glycoengineering and mass spectrometry for the improvement of biopharmaceuticals

Donini, Roberto · 2024 · Imperial College London · DOI

Full title: Glycoengineering and mass spectrometry for the improvement of biopharmaceuticals

Authors: Donini, Roberto

Year: 2024

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/111180

Thesis Assessment of the interactions between bioprocess conditions and protein glycosylation in antibody- producing mammalian cell cultures

Jimenez Del Val, Ioscani · 2014 · Imperial College London · DOI

Full title: Assessment of the interactions between bioprocess conditions and protein glycosylation in antibody- producing mammalian cell cultures

Authors: Jimenez Del Val, Ioscani

Year: 2014

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/15160

Thesis NEXT-FBA: a hybrid stoichiometric/data-driven approach to improve intracellular flux predictions

Morrissey, James; Barberi, Gianmarco; Strain, Benjamin et al. · 2025 · Imperial College London · DOI

Full title: NEXT-FBA: a hybrid stoichiometric/data-driven approach to improve intracellular flux predictions

Authors: Morrissey, James; Barberi, Gianmarco; Strain, Benjamin; Facco, Pierantonio; Kontoravdi, Cleo

Year: 2025

Venue: Imperial College London

DOI: https://hdl.handle.net/10044/1/118593

Thesis Simulation of animal cell metabolism

Barford, John Patrick; Phillips, Peter J.; Harbour, Colin · 1992 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Simulation of animal cell metabolism

Authors: Barford, John Patrick; Phillips, Peter J.; Harbour, Colin

Year: 1992

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68920

Thesis In Situ Monitoring of Intracellular Glucose and Glutamine in CHO Cell Culture

Behjousiar, A; Kontoravdi, C; Polizzi, KM · 2014 · Imperial College London · DOI

Full title: In Situ Monitoring of Intracellular Glucose and Glutamine in CHO Cell Culture

Authors: Behjousiar, A; Kontoravdi, C; Polizzi, KM

Year: 2014

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/14483

Thesis A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation

Jimenez del Val, I; Polizzi, K; Kontoravdi, C · 2016 · Imperial College London · DOI

Full title: A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation

Authors: Jimenez del Val, I; Polizzi, K; Kontoravdi, C

Year: 2016

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/33608

Thesis From titer to quality: exploring reinforcement learning for bioprocess control in silico

Monteiro, Mariana; Flevaris, Konstantinos; Kontoravdi, Cleo · 2025 · Imperial College London · DOI

Full title: From titer to quality: exploring reinforcement learning for bioprocess control in silico

Authors: Monteiro, Mariana; Flevaris, Konstantinos; Kontoravdi, Cleo

Year: 2025

Venue: Imperial College London

DOI: https://hdl.handle.net/10044/1/124760

Thesis In situ FRET Biosensors for the in vivo measurement of important metabolites during cell culture

Behjousiar, Alireza · 2015 · Imperial College London · DOI

Full title: In situ FRET Biosensors for the in vivo measurement of important metabolites during cell culture

Authors: Behjousiar, Alireza

Year: 2015

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/24852

Thesis Development and application of genome-scale models in chinese hamster ovary cell culture

Morrissey, Richard James · 2025 · Imperial College London · DOI

Full title: Development and application of genome-scale models in chinese hamster ovary cell culture

Authors: Morrissey, Richard James

Year: 2025

Venue: Imperial College London

DOI: https://hdl.handle.net/10044/1/122460

Thesis Towards continuous biomanufacturing a computational approach for the intensification of monoclonal antibody production

Papathanasiou, Maria · 2017 · Imperial College London · DOI

Full title: Towards continuous biomanufacturing a computational approach for the intensification of monoclonal antibody production

Authors: Papathanasiou, Maria

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/49449

Thesis In silico dynamic optimisation studies for batch/fed-batch mammalian cell suspension cultures producing biopharmaceuticals

Lam, Ming-Chi · 2017 · Imperial College London · DOI

Full title: In silico dynamic optimisation studies for batch/fed-batch mammalian cell suspension cultures producing biopharmaceuticals

Authors: Lam, Ming-Chi

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/45465

Thesis Amino acid metabolism in Chinese hamster ovary cell culture

Kyriakopoulos, Sarantos · 2015 · Imperial College London · DOI

Full title: Amino acid metabolism in Chinese hamster ovary cell culture

Authors: Kyriakopoulos, Sarantos

Year: 2015

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/25143

Thesis Improved bioprocess with CHO-hTSH cells on higher microcarrier concentration provides higher overall biomass and productivity for rhTSH

Pereira, Carlos Augusto · 2011 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Improved bioprocess with CHO-hTSH cells on higher microcarrier concentration provides higher overall biomass and productivity for rhTSH

Authors: Pereira, Carlos Augusto

Year: 2011

Venue: Universidade de São Paulo – USP Digital Library

DOI: http://www.springerlink.com/content/0273-2289/164/4/

Thesis The Engineering of Chinese Hamster Ovary Cells to Achieve More Efficient Gene Amplification for Improving Biopharmaceutical Development

Cacciatore, Jonathan Joseph · 2012 · Columbia University · DOI

Full title: The Engineering of Chinese Hamster Ovary Cells to Achieve More Efficient Gene Amplification for Improving Biopharmaceutical Development

Authors: Cacciatore, Jonathan Joseph

Year: 2012

Venue: Columbia University

DOI: https://doi.org/10.7916/D8DV1RZD

Thesis Desenvolvimento de bioprocessos com células S2 e CHO em biorreatores para produção de proteínas recombinantes

Pereira, Carlos Augusto · 2010 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Desenvolvimento de bioprocessos com células S2 e CHO em biorreatores para produção de proteínas recombinantes

Authors: Pereira, Carlos Augusto

Year: 2010

Venue: Universidade de São Paulo – USP Digital Library

DOI: 001835801

Thesis A Systematic Framework to Optimize and Control Monoclonal Antibody Manufacturing Process

Li, Ying Fei · 2018 · Columbia University · DOI

Full title: A Systematic Framework to Optimize and Control Monoclonal Antibody Manufacturing Process

Authors: Li, Ying Fei

Year: 2018

Venue: Columbia University

DOI: https://doi.org/10.7916/D8GX5TJP

Thesis Direct quality control of glycoengineered erythropoietin variants

Čaval, Tomislav; Tian, Weihua; Yang, Zhang et al. · 2018 · Utrecht University · DOI

Full title: Direct quality control of glycoengineered erythropoietin variants

Authors: Čaval, Tomislav; Tian, Weihua; Yang, Zhang; Clausen, Henrik; Heck, Albert J R

Year: 2018

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/368318

Thesis Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra

Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn et al. · 2021 · Utrecht University · DOI

Full title: Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra

Authors: Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn; Mastrobattista, Enrico; Yamabhai, Montarop

Year: 2021

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/418108

Thesis Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Zhang, Liang · 2020 · KTH Royal Institute of Technology · DOI

Full title: Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Authors: Zhang, Liang

Year: 2020

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-273343

Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn et al. · 2021 · Utrecht University · DOI

Authors: Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn; Mastrobattista, Enrico; Yamabhai, Montarop

Year: 2021

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/419433

Thesis Suitability of transiently expressed antibodies for clinical studies: product quality consistency at different production scales

Rodriguez-Conde, Sara; Inman, Sophie; Lindo, Viv et al. · 2022 · Utrecht University · DOI

Full title: Suitability of transiently expressed antibodies for clinical studies: product quality consistency at different production scales

Authors: Rodriguez-Conde, Sara; Inman, Sophie; Lindo, Viv; Amery, Leanne; Tang, Alison; Okorji-Obike, Uche; Du, Wenjuan; Bosch, Berend-Jan; Wichgers Schreur, Paul J; Kortekaas, Jeroen; Sola, Isabel; Enjuanes, Luis; Kerry, Laura; Mahal, Katharina; Hulley, Martyn; Daramola, Olalekan

Year: 2022

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/418557

Thesis Suitability of transiently expressed antibodies for clinical studies: product quality consistency at different production scales

Rodriguez-Conde, Sara; Inman, Sophie; Lindo, Viv et al. · 2022 · Utrecht University · DOI

Full title: Suitability of transiently expressed antibodies for clinical studies: product quality consistency at different production scales

Year: 2022

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/419893

Thesis N-linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG

van Berkel, P.H.C.; Gerritsen, J.; Perdok, G. et al. · 2009 · Utrecht University · DOI

Full title: N-linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG

Authors: van Berkel, P.H.C.; Gerritsen, J.; Perdok, G.; Valbjørn, J.; Vink, T.; van de Winkel, J.G.J.; Parren, P.W.H.I.

Year: 2009

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/42525

Thesis Changes in the Overall Extent of Protein Glycosylation by Chinese Hamster Ovary Cells Over the Course of Batch Culture

Yuk, Inn Huam Yvonne.; Wang, Daniel I.C. · 2003 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Changes in the Overall Extent of Protein Glycosylation by Chinese Hamster Ovary Cells Over the Course of Batch Culture

Authors: Yuk, Inn Huam Yvonne.; Wang, Daniel I.C.

Year: 2003

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/3776

Thesis Glycosylation by Chinese Hamster Ovary Cells in Dolichol Phosphate-Supplemented Cultures

Yuk, Inn Huam Yvonne.; Wang, Daniel I.C. · 2003 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Glycosylation by Chinese Hamster Ovary Cells in Dolichol Phosphate-Supplemented Cultures

Authors: Yuk, Inn Huam Yvonne.; Wang, Daniel I.C.

Year: 2003

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/3784

Thesis Characterization and improvement of interferon-[gamma] glycosylation in Chinese hamster ovary cell culture

Gu, Xuejun, 1970- · 2005 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Characterization and improvement of interferon-[gamma] glycosylation in Chinese hamster ovary cell culture

Authors: Gu, Xuejun, 1970-

Year: 2005

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/8796

Thesis Development of biologics for use in translational medicine

Jain, Saurabh Ashok · 2017 · The University of Edinburgh · DOI

Full title: Development of biologics for use in translational medicine

Authors: Jain, Saurabh Ashok

Year: 2017

Venue: The University of Edinburgh

DOI: http://hdl.handle.net/1842/21117

Thesis Improving monoclonal antibody production from Chinese hamster ovary cells

Donaldson, James · 2024 · The University of Edinburgh · DOI

Full title: Improving monoclonal antibody production from Chinese hamster ovary cells

Authors: Donaldson, James

Year: 2024

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/41771

Thesis Metabolomics-driven investigation of novel growth inhibitors in CHO cell bioprocessing

Johnston, Luke · 2025 · The University of Edinburgh · DOI

Full title: Metabolomics-driven investigation of novel growth inhibitors in CHO cell bioprocessing

Authors: Johnston, Luke

Year: 2025

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/44239

Thesis Process modelling and optimisation of biomolecular reactions and separations for advanced biopharmaceutical manufacturing

Jones, Wil · 2024 · The University of Edinburgh · DOI

Full title: Process modelling and optimisation of biomolecular reactions and separations for advanced biopharmaceutical manufacturing

Authors: Jones, Wil

Year: 2024

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/41822

Thesis CHO Cell Genetic Instability: From Transfection to Stable Cell Line

Cartwright, Joseph · 2016 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: CHO Cell Genetic Instability: From Transfection to Stable Cell Line

Authors: Cartwright, Joseph

Year: 2016

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/13986/1/Joe%20Cartwright%20Thesis.pdf

Thesis Effect of Cell Culture Environment on the Stability of IgG1

Anderson, Kimberley · 2018 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Effect of Cell Culture Environment on the Stability of IgG1

Authors: Anderson, Kimberley

Year: 2018

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/25641/1/Thesis_Kimberley_Anderson%20v5.0.docx

Thesis The Epigenetics (Histone PTMs) of Therapeutic Protein Production in CHO Cells

Hanson, Eleanor · 2019 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: The Epigenetics (Histone PTMs) of Therapeutic Protein Production in CHO Cells

Authors: Hanson, Eleanor

Year: 2019

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/22945/1/Final%20version%20of%20complete%20thesis-corrections.docx

Thesis Development of a High-Throughput Analytical Platform for the Characterisation of Biopharmaceuticals Generated from Multi-Gene Engineered CHO Cells

Lambiase, Giulia · 2022 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Development of a High-Throughput Analytical Platform for the Characterisation of Biopharmaceuticals Generated from Multi-Gene Engineered CHO Cells

Authors: Lambiase, Giulia

Year: 2022

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: oai:etheses.whiterose.ac.uk:30561

Thesis Synthetic Biology Platform Development for Manufacture of Next Generation Biologics

O'Neill, Pamela · 2022 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Synthetic Biology Platform Development for Manufacture of Next Generation Biologics

Authors: O'Neill, Pamela

Year: 2022

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: oai:etheses.whiterose.ac.uk:33526

Thesis Evaluation and characterisation of phenotypic heterogeneity in Chinese Hamster Ovary cell populations during long-term culture

Fernandez Martell, Alejandro · 2015 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Evaluation and characterisation of phenotypic heterogeneity in Chinese Hamster Ovary cell populations during long-term culture

Authors: Fernandez Martell, Alejandro

Year: 2015

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/9152/7/PhD%20thesis%20Alejandro%20Fernandez%20Martell%20%28final%20version%29.pdf

Thesis Expression and interaction studies of recombinant human monoclonal antibodies

Daniel X Johansson (19525819) · 2007 · Karolinska Institutet · DOI

Full title: Expression and interaction studies of recombinant human monoclonal antibodies

Authors: Daniel X Johansson (19525819)

Year: 2007

Venue: Karolinska Institutet

DOI: oai:figshare.com:article/26917288

Thesis Engineering the expression of "difficult-to-express" recombinant monoclonal antibodies in Chinese Hamster Ovary cells

Pybus, Leon P. · 2014 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Engineering the expression of "difficult-to-express" recombinant monoclonal antibodies in Chinese Hamster Ovary cells

Authors: Pybus, Leon P.

Year: 2014

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: oai:etheses.whiterose.ac.uk:6638

Thesis Expression of recombinant neutralizing anti-HIV-1 antibodies in bacteria and eukaryotic cells

Fayezeh Yari (19526845) · 2007 · Karolinska Institutet · DOI

Full title: Expression of recombinant neutralizing anti-HIV-1 antibodies in bacteria and eukaryotic cells

Authors: Fayezeh Yari (19526845)

Year: 2007

Venue: Karolinska Institutet

DOI: oai:figshare.com:article/26920558

Thesis Serum-free large-scale transient transfection of CHO cells

Derouazi, M.; Girard, P.; Van Tilborgh, F. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Serum-free large-scale transient transfection of CHO cells

Authors: Derouazi, M.; Girard, P.; Van Tilborgh, F.; Iglesias, K.; Muller, N.; Bertschinger, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7662

Thesis Manufacture of Recombinant Therapeutic Proteins Using Chinese Hamster Ovary Cells in Large-Scale Bioreactors History, Methods, and Perspectives

Wurm, Florian Maria; de Jesus, Maria · 2025 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Manufacture of Recombinant Therapeutic Proteins Using Chinese Hamster Ovary Cells in Large-Scale Bioreactors History, Methods, and Perspectives

Authors: Wurm, Florian Maria; de Jesus, Maria

Year: 2025

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/248255

Thesis Integration and stability of CHO amplicons containing plasmid sequences

Wurm, F. M.; Pallavicini, M. G.; Arathoon, R. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Integration and stability of CHO amplicons containing plasmid sequences

Authors: Wurm, F. M.; Pallavicini, M. G.; Arathoon, R.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7594

Thesis Low-temperature pausing of cultivated mammalian cells

Hunt, L.; Hacker, D. L.; Grosjean, F. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Low-temperature pausing of cultivated mammalian cells

Authors: Hunt, L.; Hacker, D. L.; Grosjean, F.; De Jesus, M.; Uebersax, L.; Jordan, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9752

Thesis Production of recombinant protein therapeutics in cultivated mammalian cells

Wurm, F. M. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Production of recombinant protein therapeutics in cultivated mammalian cells

Authors: Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7667

Thesis CHO expression of a novel human recombinant IgG1 anti-RhD antibody isolated by phage display

Miescher, S.; Zahn-Zabal, M.; De Jesus, M. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: CHO expression of a novel human recombinant IgG1 anti-RhD antibody isolated by phage display

Authors: Miescher, S.; Zahn-Zabal, M.; De Jesus, M.; Moudry, R.; Fisch, I.; Vogel, M.; Kobr, M.; Imboden, M. A.; Kragten, E.; Bichler, J.; Mermod, N.; Stadler, B. M.; Amstutz, H.; Wurm, F.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7585

Thesis Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells

Berger, Audrey; Le Fourn, Valerie; Masternak, Jacqueline et al. · 2020 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells

Authors: Berger, Audrey; Le Fourn, Valerie; Masternak, Jacqueline; Regamey, Alexandre; Bodenmann, Iris; Girod, Pierre-Alain; Mermod, Nicolas

Year: 2020

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/167095

Thesis Accelerating the development time of recombinant mammalian cell lines producing high titers of protein therapeutics

Chenuet, Sébastien · 2008 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Accelerating the development time of recombinant mammalian cell lines producing high titers of protein therapeutics

Authors: Chenuet, Sébastien

Year: 2008

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/25783

Thesis 25 years of recombinant proteins from reactor-grown cells — Where do we go from here?

Hacker, David L.; De Jesus, Maria; Wurm, Florian M. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: 25 years of recombinant proteins from reactor-grown cells — Where do we go from here?

Authors: Hacker, David L.; De Jesus, Maria; Wurm, Florian M.

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41353

Thesis Coexpression of acidic fibroblast growth factor enhances specific productivity and antibody titers in transiently transfected HEK293 cells

Backliwal, G; Hildinger, M; Chenuet, S et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Coexpression of acidic fibroblast growth factor enhances specific productivity and antibody titers in transiently transfected HEK293 cells

Authors: Backliwal, G; Hildinger, M; Chenuet, S; Dejesus, M; Wurm, FM

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41397

Thesis Development of a predictive model for cell growth in shaken bioreactors as a function of the effects of temperature, oxygen transfer rate and seeding cell concentration

Broccard, Gilles · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Development of a predictive model for cell growth in shaken bioreactors as a function of the effects of temperature, oxygen transfer rate and seeding cell concentration

Authors: Broccard, Gilles

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/44716

Thesis Calcium phosphate transfection generates mammalian recombinant cell lines with higher specific productivity than polyfection

Chenuet, S; Martinet, D; Besuchet-Schmutz, N et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Calcium phosphate transfection generates mammalian recombinant cell lines with higher specific productivity than polyfection

Authors: Chenuet, S; Martinet, D; Besuchet-Schmutz, N; Wicht, M; Jaccard, N; Bon, AC; Derouazi, M; Hacker, DL; Beckmann, JS; Wurm, FM

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41402

Thesis Recombinant therapeutic protein production in cultivated mammalian cells: current status and future prospects

Matasci, Mattia; Hacker, David L.; Baldi, Lucia et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Recombinant therapeutic protein production in cultivated mammalian cells: current status and future prospects

Authors: Matasci, Mattia; Hacker, David L.; Baldi, Lucia; Wurm, Florian M.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/48115

Thesis Manufacturing recombinant proteins in kg-ton quantities using animal cells in bioreactors

De Jesus, Maria; Wurm, Florian M. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Manufacturing recombinant proteins in kg-ton quantities using animal cells in bioreactors

Authors: De Jesus, Maria; Wurm, Florian M.

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/64283

Thesis A simple high-yielding process for transient gene expression in CHO cells

Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia et al. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A simple high-yielding process for transient gene expression in CHO cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/70206

Thesis Novel orbital shake bioreactors for transient production of CHO derived IgGs

Stettler, Matthieu; Zhang, Xiaowei; Hacker, David L. et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Novel orbital shake bioreactors for transient production of CHO derived IgGs

Authors: Stettler, Matthieu; Zhang, Xiaowei; Hacker, David L.; De Jesus, Maria; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/83449

Thesis Disposable 600-mL orbitally shaken bioreactor for mammalian cell cultivation in suspension

Monteil, Dominique T.; Tontodonati, Giulia; Ghimire, Saroj et al. · 2013 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Disposable 600-mL orbitally shaken bioreactor for mammalian cell cultivation in suspension

Authors: Monteil, Dominique T.; Tontodonati, Giulia; Ghimire, Saroj; Baldi, Lucia; Hacker, David L.; Bürki, Cédric A.; Wurm, Florian M.

Year: 2013

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/91783

Thesis Lentiviral Vector-Mediated Gene Delivery for the Generation of Chinese Hamster Ovary Cell Lines with Improved Productivity and Stability

Oberbek, Agata · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Lentiviral Vector-Mediated Gene Delivery for the Generation of Chinese Hamster Ovary Cell Lines with Improved Productivity and Stability

Authors: Oberbek, Agata

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/52293

Thesis Glycan variability on a recombinant IgG antibody transiently produced in HEK-293E cells

Nallet, Sophie; Fornelli, Luca; Schmitt, Simone et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Glycan variability on a recombinant IgG antibody transiently produced in HEK-293E cells

Authors: Nallet, Sophie; Fornelli, Luca; Schmitt, Simone; Parra, Julien; Baldi, Lucia; Tsybin, Yury O.; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/79951

Thesis Generation of stable, high-producing cho cell lines by lentiviral vector-mediated gene transfer in serum-free suspension culture

Oberbek, Agata; Matasci, Mattia; Hacker, David L. et al. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Generation of stable, high-producing cho cell lines by lentiviral vector-mediated gene transfer in serum-free suspension culture

Authors: Oberbek, Agata; Matasci, Mattia; Hacker, David L.; Wurm, Florian M.

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/64220

Thesis Orbitally shaken bioreactors for mammalian cell culture : engineering characterization and bioprocess scale-up

Zhang, Xiaowei · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Orbitally shaken bioreactors for mammalian cell culture : engineering characterization and bioprocess scale-up

Authors: Zhang, Xiaowei

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41858

Thesis Efficient and reproducible mammalian cell bioprocesses without probes and controllers?

Tissot, Stéphanie; Oberbek, Agata; Reclari, Martino et al. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Efficient and reproducible mammalian cell bioprocesses without probes and controllers?

Authors: Tissot, Stéphanie; Oberbek, Agata; Reclari, Martino; Dreyer, Matthieu; Hacker, David L.; Baldi, Lucia; Farhat, Mohamed; Wurm, Florian Maria

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/64893

Thesis Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

Zagari, Francesca; Jordan, Martin; Stettler, Matthieu et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

Authors: Zagari, Francesca; Jordan, Martin; Stettler, Matthieu; Broly, Hervé; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/83342

Thesis Multigene expression in stable CHO cell pools generated with the piggyBac transposon system

Balasubramanian, Sowmya; Wurm, Florian M.; Hacker, David L. · 2017 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Multigene expression in stable CHO cell pools generated with the piggyBac transposon system

Authors: Balasubramanian, Sowmya; Wurm, Florian M.; Hacker, David L.

Year: 2017

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/133808

Thesis Rapid recombinant protein production from piggyBac transposon-mediated stable CHO cell pools

Balasubramanian, Sowmya; Matasci, Mattia; Kadlecova, Zuzana et al. · 2015 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Rapid recombinant protein production from piggyBac transposon-mediated stable CHO cell pools

Authors: Balasubramanian, Sowmya; Matasci, Mattia; Kadlecova, Zuzana; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2015

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/113975

Thesis Enhanced Plasmid DNA Utilization in Transiently Transfected CHO-DG44 Cells in the Presence of Polar Solvents

Rajendra, Yashas; Balasubramanian, Sowmya; Kiseljak, Divor et al. · 2016 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Enhanced Plasmid DNA Utilization in Transiently Transfected CHO-DG44 Cells in the Presence of Polar Solvents

Authors: Rajendra, Yashas; Balasubramanian, Sowmya; Kiseljak, Divor; Baldi, Lucia; Wurm, Florian M.; Hacker, David L.

Year: 2016

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/124119

Thesis A comparison of orbitally-shaken and stirred-tank bioreactors: pH modulation and bioreactor type affect CHO cell growth and protein glycosylation

Monteil, Dominique T.; Juvet, Valentin; Paz, Jonathan et al. · 2017 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A comparison of orbitally-shaken and stirred-tank bioreactors: pH modulation and bioreactor type affect CHO cell growth and protein glycosylation

Authors: Monteil, Dominique T.; Juvet, Valentin; Paz, Jonathan; Moniatte, Marc; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2017

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/133807

Thesis Comparison of different bioreactors and media for the production of specific monoclonal IgA antibodies

Stoll, T. S.; Perregaux, C.; Von Stockar, U. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Comparison of different bioreactors and media for the production of specific monoclonal IgA antibodies

Authors: Stoll, T. S.; Perregaux, C.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/225995

Thesis Production of immunoglobulin A in different reactor configurations

Stoll, T.; Perregaux, C.; Von Stockar, U. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Production of immunoglobulin A in different reactor configurations

Authors: Stoll, T.; Perregaux, C.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/225985

Thesis CHO Quasispecies—Implications for Manufacturing Processes

Wurm, Florian · 2014 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: CHO Quasispecies—Implications for Manufacturing Processes

Authors: Wurm, Florian

Year: 2014

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/103490

Thesis Batch cultures of a hybridoma cell line performed with in situ ammonia removal

Schneider, Markus; El Alaoui, Mounia; von Stockar, Urs et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Batch cultures of a hybridoma cell line performed with in situ ammonia removal

Authors: Schneider, Markus; El Alaoui, Mounia; von Stockar, Urs; Marison, Ian W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226018

Thesis Characterization of Fibra-Cel® packed-bed bioreactors for the culture of CHO cells

Meuwly, Frédéric · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Characterization of Fibra-Cel® packed-bed bioreactors for the culture of CHO cells

Authors: Meuwly, Frédéric

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/218454

Thesis Process development for the production of monoclonal IgA antibodies that protect mucosal surfaces

Stoll, T. S.; Perregaux, C.; Stockar, U. von et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Process development for the production of monoclonal IgA antibodies that protect mucosal surfaces

Authors: Stoll, T. S.; Perregaux, C.; Stockar, U. von; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/225978

Thesis Automated microfluidic sorting of mammalian cells labeled with magnetic microparticles for those that efficiently express and secrete a protein of interest

Droz, Xuan; Harraghy, Niamh; Lancon, Etienne et al. · 2017 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Automated microfluidic sorting of mammalian cells labeled with magnetic microparticles for those that efficiently express and secrete a protein of interest

Authors: Droz, Xuan; Harraghy, Niamh; Lancon, Etienne; Le Fourn, Valerie; Calabrese, David; Colombet, Thierry; Liechti, Pascal; Rida, Amar; Girod, Pierre-Alain; Mermod, Nicolas

Year: 2017

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/138887

Thesis Mid-infrared spectroscopic monitoring of animal cell culture bioreactor processes

Rhiel, M.; Ziegler, T.; Ducommun, P. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Mid-infrared spectroscopic monitoring of animal cell culture bioreactor processes

Authors: Rhiel, M.; Ziegler, T.; Ducommun, P.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226036

Thesis Monitoring of temperature effects on animal cell metabolism in a packed bed process

Ducommun, P.; Rueux, P. A.; Kadouri, A. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Monitoring of temperature effects on animal cell metabolism in a packed bed process

Authors: Ducommun, P.; Rueux, P. A.; Kadouri, A.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226069

Thesis Characterization of monoclonal IgA production and activity in hollow-fiber and fluidized-bed reactors

Stoll, T. S.; Ruffieux, P. A.; Lluella, E. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Characterization of monoclonal IgA production and activity in hollow-fiber and fluidized-bed reactors

Authors: Stoll, T. S.; Ruffieux, P. A.; Lluella, E.; von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226009

Thesis Online calorimetry as a technique for process monitoring and control in biotechnology

vonStockar, Urs; Duboc, Philippe; Menoud, Laurent et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Online calorimetry as a technique for process monitoring and control in biotechnology

Authors: vonStockar, Urs; Duboc, Philippe; Menoud, Laurent; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226013

Thesis All-in-one bioprocess monitoring with a mid-IR spectroscopic sensor

Rhiel, Martin; Cannizzaro, Christopher; Marison, Ian et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: All-in-one bioprocess monitoring with a mid-IR spectroscopic sensor

Authors: Rhiel, Martin; Cannizzaro, Christopher; Marison, Ian; von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226049

Thesis Effects of culture conditions on the production and quality of monoclonal IgA

Stoll, T. S.; Chappaz, A.; von Stockar, U. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Effects of culture conditions on the production and quality of monoclonal IgA

Authors: Stoll, T. S.; Chappaz, A.; von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226015

Thesis Systematic improvement of a chemically-defined protein-free medium for hybridoma growth and monoclonal antibody production

Stoll, T. S.; Muhlethaler, K.; von Stockar, U. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Systematic improvement of a chemically-defined protein-free medium for hybridoma growth and monoclonal antibody production

Authors: Stoll, T. S.; Muhlethaler, K.; von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/225998

Thesis The role of vitamins and amino acids on hybridoma growth and monoclonal antibody production

Ducommun, Paul; Ruffieux, Pierre-Alain; von Stockar, Urs et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: The role of vitamins and amino acids on hybridoma growth and monoclonal antibody production

Authors: Ducommun, Paul; Ruffieux, Pierre-Alain; von Stockar, Urs; Marison, Ian

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226050

Thesis On-line determination of animal cell concentration in two industrial high-density culture processes by dielectric spectroscopy

Ducommun, P.; Kadouri, A.; Von Stockar, U. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-line determination of animal cell concentration in two industrial high-density culture processes by dielectric spectroscopy

Authors: Ducommun, P.; Kadouri, A.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226068

Thesis Real-time in situ monitoring of freely suspended and immobilized cell cultures based on mid-infrared spectroscopic measurements

Rhiel, Martin; Ducommun, Paul; Bolzonella, Ivan et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Real-time in situ monitoring of freely suspended and immobilized cell cultures based on mid-infrared spectroscopic measurements

Authors: Rhiel, Martin; Ducommun, Paul; Bolzonella, Ivan; Marison, Ian; Von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226062

Thesis On-line determination of animal cell concentration

Ducommun, P.; Bolzonella, I.; Rhiel, M. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-line determination of animal cell concentration

Authors: Ducommun, P.; Bolzonella, I.; Rhiel, M.; Pugeaud, P.; von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226053

Thesis Factors affecting the production and quality of IgA antibodies active against V. cholerae

Marison, Ian; Stoll, Thibaud S.; Lullau, Elke et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Factors affecting the production and quality of IgA antibodies active against V. cholerae

Authors: Marison, Ian; Stoll, Thibaud S.; Lullau, Elke; Von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226014

Thesis Biotechnology in Lausanne. The Rh D project

Von Stockar, Urs; Kragten, Eddy; Marison, Ian W. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Biotechnology in Lausanne. The Rh D project

Authors: Von Stockar, Urs; Kragten, Eddy; Marison, Ian W.; Amstutz, Hanspeter; Miescher, Sylvia; Fisch, Igor; Mermod, Nicolas; De Jesus, Maria; Freitag, Ruth; Wurm, Florian

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226042

Thesis The effect of cell line, transfection procedure and reactor conditions on the glycosylation of recombinant human anti-rhesus D IGG1

Nahrgang, S.; Kragten, E.; De Jesus, M. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: The effect of cell line, transfection procedure and reactor conditions on the glycosylation of recombinant human anti-rhesus D IGG1

Authors: Nahrgang, S.; Kragten, E.; De Jesus, M.; Bourgeois, M.; Dejardin, S.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226039

Thesis A new method for on-line measurement of the volumetric oxygen uptake rate in membrane aerated animal cell cultures

Ducommun, P.; Ruffieux, P. A.; Furter, M. P. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A new method for on-line measurement of the volumetric oxygen uptake rate in membrane aerated animal cell cultures

Authors: Ducommun, P.; Ruffieux, P. A.; Furter, M. P.; Marison, I.; von Stockar, U.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226045

Thesis On-line biomass monitoring with scanning dielectric spectroscopy

Cannizzaro, Christopher M.; Valentinotti, Sergio; Marison, Ian W. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-line biomass monitoring with scanning dielectric spectroscopy

Authors: Cannizzaro, Christopher M.; Valentinotti, Sergio; Marison, Ian W.; von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226087

Thesis On-line biomass monitoring of CHO perfusion culture with scanning dielectric spectroscopy

Cannizzaro, Christopher; Guegerli, Raphael; Marison, Ian et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-line biomass monitoring of CHO perfusion culture with scanning dielectric spectroscopy

Authors: Cannizzaro, Christopher; Guegerli, Raphael; Marison, Ian; von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226088

Thesis Metabolic flux analysis of hybridoma cells in different culture media using mass balances

Bonarius, Hendrik P. J.; Hatzimanikatis, Vassily; Meesters, Koen P. H. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Metabolic flux analysis of hybridoma cells in different culture media using mass balances

Authors: Bonarius, Hendrik P. J.; Hatzimanikatis, Vassily; Meesters, Koen P. H.; de Gooijer, Cornelis D.; Schmid, Georg; Tramper, Johannes

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/238768

Thesis CHARACTERIZING CELL LINE AND MEDIA PERFORMANCE OVER EXTENDED PERIODS THROUGH COMPUTATIONAL AND BIOINFORMATIC APPROACHES

Rapp, Kent Michael · 2025 · Johns Hopkins University · DOI

Full title: CHARACTERIZING CELL LINE AND MEDIA PERFORMANCE OVER EXTENDED PERIODS THROUGH COMPUTATIONAL AND BIOINFORMATIC APPROACHES

Authors: Rapp, Kent Michael

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70290

Thesis ENGINEERING BIOSENSOR CELL LINES TO INVESTIGATE INTRACELLULAR IMPACTS OF MAMMALIAN BIOPROCESSES

McFarland, Kevin Stephen · 2023 · Johns Hopkins University · DOI

Full title: ENGINEERING BIOSENSOR CELL LINES TO INVESTIGATE INTRACELLULAR IMPACTS OF MAMMALIAN BIOPROCESSES

Authors: McFarland, Kevin Stephen

Year: 2023

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/68933

Thesis Investigating the Use of Dipeptides as Singular Amino Acid Replacements in Chinese Hamster Ovary Cell Cultures

Mitchell, Makayla N · 2025 · Johns Hopkins University · DOI

Full title: Investigating the Use of Dipeptides as Singular Amino Acid Replacements in Chinese Hamster Ovary Cell Cultures

Authors: Mitchell, Makayla N

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70799

Thesis STRUCTURAL IMPLICATIONS OF GLUCOSE AND COPPER AVAILABILITY ON GLYCATION PROCESSES IN CHINESE HAMSTER OVARIAN (CHO) CELL-DERIVED PROTEINS

Vasamsetti, Sree Lakshmi Harita · 2025 · Johns Hopkins University · DOI

Full title: STRUCTURAL IMPLICATIONS OF GLUCOSE AND COPPER AVAILABILITY ON GLYCATION PROCESSES IN CHINESE HAMSTER OVARIAN (CHO) CELL-DERIVED PROTEINS

Authors: Vasamsetti, Sree Lakshmi Harita

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70784

Thesis BRIDGING EXPERIMENTAL AND IN-SILICO METHODS FOR ADVANCED MAMMALIAN BIOMANUFACTURING OPTIMIZATION

Ndahiro, Nelson · 2025 · Johns Hopkins University · DOI

Full title: BRIDGING EXPERIMENTAL AND IN-SILICO METHODS FOR ADVANCED MAMMALIAN BIOMANUFACTURING OPTIMIZATION

Authors: Ndahiro, Nelson

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70287

Thesis Understanding mammalian cell metabolism and developing cell culture strategies for enhanced manufacturing of biotherapeutics

Ladiwala, Pranay · 2025 · Johns Hopkins University · DOI

Full title: Understanding mammalian cell metabolism and developing cell culture strategies for enhanced manufacturing of biotherapeutics

Authors: Ladiwala, Pranay

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70273

Thesis A scoping review of supervised learning modelling and data-driven optimisation in monoclonal antibody process development

Pham, TD; Manapragada, C; Sun, Y et al. · 2023 · University of Melbourne · DOI

Full title: A scoping review of supervised learning modelling and data-driven optimisation in monoclonal antibody process development

Authors: Pham, TD; Manapragada, C; Sun, Y; Bassett, R; Aickelin, U

Year: 2023

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/325201

Thesis Tuning Post-Translational Modifications in Mammalian Cells: Exploring Media Optimization and Gene Editing Strategies

Aliyu, Lateef · 2025 · Johns Hopkins University · DOI

Full title: Tuning Post-Translational Modifications in Mammalian Cells: Exploring Media Optimization and Gene Editing Strategies

Authors: Aliyu, Lateef

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70660

Thesis Metabolic-flux analysis of mammalian-cell culture

Bonarius, H.P.J. · 1998 · Wageningen University & Research · DOI

Full title: Metabolic-flux analysis of mammalian-cell culture

Authors: Bonarius, H.P.J.

Year: 1998

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/metabolic-flux-analysis-of-mammalian-cell-culture

Thesis Acoustic perfusion processes for hybridoma cultures: viability, cell cycle and metabolic analysis

Dalm, M.C.F. · 2007 · Wageningen University & Research · DOI

Full title: Acoustic perfusion processes for hybridoma cultures: viability, cell cycle and metabolic analysis

Authors: Dalm, M.C.F.

Year: 2007

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/acoustic-perfusion-processes-for-hybridoma-cultures-viability-cel

Thesis Discovering Changes in Cell Stability Using Process Mining: A Case Study

Zhou, J; Armas-Cervantes, A; Bozorgi, ZD et al. · 2024 · University of Melbourne · DOI

Full title: Discovering Changes in Cell Stability Using Process Mining: A Case Study

Authors: Zhou, J; Armas-Cervantes, A; Bozorgi, ZD; Otte, E; Polyvyanyy, A

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/354056

Thesis Characterization and optimization of a CHO antibody manufacturing process

Reger, Lucas Nik · 2025 · Wageningen University & Research · DOI

Full title: Characterization and optimization of a CHO antibody manufacturing process

Authors: Reger, Lucas Nik

Year: 2025

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/characterization-and-optimization-of-a-cho-antibody-manufacturing

Thesis Design, characterization and application of the multiple air-lift loop bioreactor

Bakker, W.A.M. · 1995 · Wageningen University & Research · DOI

Full title: Design, characterization and application of the multiple air-lift loop bioreactor

Authors: Bakker, W.A.M.

Year: 1995

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/design-characterization-and-application-of-the-multiple-air-lift-

Thesis Monoclonal Antibody Production and Purification

McMahon, Hope E; Schwartz, Jessica W; Ray, Shritama · 2023 · University of Pennsylvania · DOI

Full title: Monoclonal Antibody Production and Purification

Authors: McMahon, Hope E; Schwartz, Jessica W; Ray, Shritama

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/5925

Thesis Scale-down of CHO cell fed-batch cultures

Pan, Xiao · 2018 · Wageningen University & Research · DOI

Full title: Scale-down of CHO cell fed-batch cultures

Authors: Pan, Xiao

Year: 2018

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/scale-down-of-cho-cell-fed-batch-cultures

Thesis Transcriptomic profiling as a tool to characterize CHO cell processes

Al Sayyari, Abdulaziz Abdullah · 2018 · Wageningen University & Research · DOI

Full title: Transcriptomic profiling as a tool to characterize CHO cell processes

Authors: Al Sayyari, Abdulaziz Abdullah

Year: 2018

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/transcriptomic-profiling-as-a-tool-to-characterize-cho-cell-proce

Thesis Growth and death of animal cells in bioreactors

Martens, D.E. · 1996 · Wageningen University & Research · DOI

Full title: Growth and death of animal cells in bioreactors

Authors: Martens, D.E.

Year: 1996

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/growth-and-death-of-animal-cells-in-bioreactors

Thesis Development and validation of a hybrid model for prediction of viable cell density, titer and cumulative glucose consumption in a mammalian cell culture system

Yatipanthalawa, BS; Wallace Fitzsimons, SE; Horning, T et al. · 2024 · University of Melbourne · DOI

Full title: Development and validation of a hybrid model for prediction of viable cell density, titer and cumulative glucose consumption in a mammalian cell culture system

Authors: Yatipanthalawa, BS; Wallace Fitzsimons, SE; Horning, T; Lee, YY; Gras, SL

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/345116

Thesis A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

Fan, Yuzhou; Jimenez Del Val, Ioscani; Müller, Christian et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

Authors: Fan, Yuzhou; Jimenez Del Val, Ioscani; Müller, Christian; Lund, Anne Mathilde; Wagtberg Sen, Jette; Rasmussen, Søren Kofoed; Kontoravdi, Cleo; Baycin-Hizal, Deniz; Betenbaugh, Michael J.; Weilguny, Dietmar; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/032ff7ec-9b40-4a61-8f15-f7c40fa6a14e

Thesis Reprogramming amino acid catabolism in CHO cells with CRISPR-Cas9 genome editing improves cell growth and reduces by-product secretion

Ley, Daniel; Pereira, Sara; Pedersen, Lasse Ebdrup et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Reprogramming amino acid catabolism in CHO cells with CRISPR-Cas9 genome editing improves cell growth and reduces by-product secretion

Authors: Ley, Daniel; Pereira, Sara; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Hefzi, Hooman; Lund, Anne Mathilde; Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Wulff, Tune; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/02fc00d6-9e88-4356-a0b4-d3fe8193bcdd

Thesis The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

Xu, Xun; Pan, Shengkai; Liu, Xin et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

Authors: Xu, Xun; Pan, Shengkai; Liu, Xin; Chen, Wenbin; Xie, Min; Wang, Wenliang; Wang, Jun; Nagarajan, Harish; Lewis, Nathan; Famili, Iman; Palsson, Bernhard O.; Cai, Zhiming; Gui, Yaoting; Hammond, Stephanie; Lee, Kelvin H.; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Neff, Norma; Passarelli, Benedetto; Koh, Winston; Fan, H. Christina; Wang, Jianbin; Quake, Stephen R.; Betenbaugh, Michael; Palsson, Bernhard; id_orcid 0000-0003-2357-6785; Wang, Jun

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/153bbfd3-ab45-4bfe-bf95-4ccf498498d5

Thesis Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells

Saghaleyni, Rasool; Malm, Magdalena; Moruzzi, Noah et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells

Authors: Saghaleyni, Rasool; Malm, Magdalena; Moruzzi, Noah; Zrimec, Jan; Razavi, Ronia; Wistbacka, Num; Thorell, Hannes; Pintar, Anton; Hober, Andreas; Edfors, Fredrik; Chotteau, Veronique; Berggren, Per Olof; Grassi, Luigi; Zelezniak, Aleksej; Svensson, Thomas; Hatton, Diane; Nielsen, Jens; Robinson, Jonathan L.; Rockberg, Johan

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2d7082ac-461c-4bfd-9506-aee94ce2430e

Thesis Engineer medium and feed for modulating N-glycosylation of recombinant protein production in CHO cell culture

Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Engineer medium and feed for modulating N-glycosylation of recombinant protein production in CHO cell culture

Authors: Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0bd0b7c5-a59e-4460-9d0c-f80856bbbbe1

Thesis Systems metabolic engineering

Hesselberg-Thomsen, Viktor; id_orcid 0000-0001-6929-3671 · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Systems metabolic engineering

Authors: Hesselberg-Thomsen, Viktor; id_orcid 0000-0001-6929-3671

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/18523551-e95d-4dca-8278-5501b8e2ec1d

Thesis Method for reducing ammonium and lactate production in cho cells

Ley, Daniel; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808 et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Method for reducing ammonium and lactate production in cho cells

Authors: Ley, Daniel; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2eca9af1-d5e3-427f-a8d4-142c07400b20

Thesis CHO On A Detox: Removing By-Product Formation Through Cell Engineering

Pereira, Sara; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: CHO On A Detox: Removing By-Product Formation Through Cell Engineering

Authors: Pereira, Sara; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/16746af6-dbf5-46ee-a6a0-d5c8bf3c3b88

Thesis N-Glycosylation optimization of recombinant antibodies in CHO cell through process and metabolic engineering

Fan, Yuzhou · 2015 · Technical University of Denmark (DTU) · DOI

Full title: N-Glycosylation optimization of recombinant antibodies in CHO cell through process and metabolic engineering

Authors: Fan, Yuzhou

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0d46b1c0-0617-4c4e-8295-079e1eddaf3e

Thesis Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing

Lee, Jae Seong; Park, Jin Hyoung; Kwang Ha, Tae et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing

Authors: Lee, Jae Seong; Park, Jin Hyoung; Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Samoudi, Mojtaba; Lewis, Nathan E.; Palsson, Bernhard O.; id_orcid 0000-0003-2357-6785; Kildegaard, Helene Faustrup; Min Lee, Gyun

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0ae89c9f-9a27-4554-a9b0-2af9aa0614a9

Thesis Single-Batch Expression of an Experimental Recombinant Snakebite Antivenom Based on an Oligoclonal Mixture of Human Monoclonal Antibodies

Adams, Anna C.; Grav, Lise M.; id_orcid 0000-0001-8042-7108 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Single-Batch Expression of an Experimental Recombinant Snakebite Antivenom Based on an Oligoclonal Mixture of Human Monoclonal Antibodies

Authors: Adams, Anna C.; Grav, Lise M.; id_orcid 0000-0001-8042-7108; Ahmadi, Shirin; id_orcid 0000-0002-4131-583X; Holst Dahl, Camilla; Ljungars, Anne; id_orcid 0000-0002-2158-0601; Laustsen, Andreas H.; id_orcid 0000-0001-6918-5574; Nielsen, Lars K.

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1cacecb6-2d02-484b-8855-606d116d8855

Thesis Engineered CHO cells for production of diverse, homogeneous glycoproteins

Yang, Zhang; Wang, Shengjun; Halim, Adnan et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Engineered CHO cells for production of diverse, homogeneous glycoproteins

Authors: Yang, Zhang; Wang, Shengjun; Halim, Adnan; Schulz, Morten Alder; Frodin, Morten; Rahman, Shamim H.; Vester-Christensen, Malene Bech; Behrens, Carsten; Kristensen, Claus; Vakhrushev, Sergey Y.; Bennett, Eric Paul; Wandall, Hans H.; Clausen, Henrik

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/003c3b4e-4454-43e4-abe6-4365fa07ce9f

Thesis Improving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines

Kim, Che Lin; Min Lee, Gyun · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Improving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines

Authors: Kim, Che Lin; Min Lee, Gyun

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/28aaa920-fbdb-454f-9c73-2206da4ef39e

Thesis A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

Lund, Anne Mathilde; Kildegaard, Helene Faustrup; Petersen, Maja Borup Kjær et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

Authors: Lund, Anne Mathilde; Kildegaard, Helene Faustrup; Petersen, Maja Borup Kjær; Rank, Julie; Hansen, Bjarne Gram; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Mortensen, Uffe Hasbro; id_orcid 0000-0002-7794-7273

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1e6b9cdd-536a-420a-b808-622781069950

Thesis Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Hansen, Henning Gram; Nilsson, Claes Nymand; Lund, Anne Mathilde et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Authors: Hansen, Henning Gram; Nilsson, Claes Nymand; Lund, Anne Mathilde; Kol, Stefan; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lundqvist, Magnus; Rockberg, Johan; Min Lee, Gyun; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/41719bc3-f624-40be-ba5e-4449c22aac7f

Thesis Glycoengineering in CHO cells: Advances in systems biology

Tejwani, Vijay; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808 et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Glycoengineering in CHO cells: Advances in systems biology

Authors: Tejwani, Vijay; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Nam, Jong Hyun; Sharfstein, Susan T

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/18d1eb12-342d-4d7e-bfaa-aad1a918cc13

Thesis Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Martínez-Monge, I.; Martínez, C.; Decker, M. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Authors: Martínez-Monge, I.; Martínez, C.; Decker, M.; Udugama, I. A.; Marín de Mas, I.; Gernaey, K. V.; id_orcid 0000-0002-0364-1773; Nielsen, L. K.

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3b1685d4-5ab9-4737-b414-d28fecf9b9eb

Thesis Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

Pereira, Sara; Kildegaard, Helene F.; Andersen, Mikael R. et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

Authors: Pereira, Sara; Kildegaard, Helene F.; Andersen, Mikael R.; id_orcid 0000-0003-4794-6808

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/28b6ee0a-2f57-47f3-ba14-6a113e9c7800

Thesis A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism

Hefzi, Hooman; Ang, Kok Siong; Hanscho, Michael et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism

Authors: Hefzi, Hooman; Ang, Kok Siong; Hanscho, Michael; Bordbar, Aarash; Ruckerbauer, David; Lakshmanan, Meiyappan; Orellana, Camila A.; Baycin-Hizal, Deniz; Huang, Yingxiang; Ley, Daniel; Martinez, Veronica S.; Kyriakopoulos, Sarantos; Jiménez, Natalia E.; Zielinski, Daniel C.; Quek, Lake-Ee; Wulff, Tune; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Li, Shangzhong; Lee, Jae Seong; Paglia, Giuseppe; Loira, Nicolas; Spahn, Philipp N.; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Gutierrez, Jahir M.; King, Zachary A.; Lund, Anne Mathilde; Nagarajan, Harish; Thomas, Alex; Abdel-Haleem, Alyaa M.; Zanghellini, Juergen; Kildegaard, Helene Faustrup; Voldborg, Bjørn Gunnar; id_orcid 0000-0002-7005-1642; Gerdtzen, Ziomara P.; Betenbaugh, Michael J.; Palsson, Bernhard; id_orcid 0000-0003-2357-6785; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Nielsen, Lars K.; Borth, Nicole; Lee, Dong-Yup; Lewis, Nathan E.

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2f8bb3cd-eb0c-46f7-b39b-3791d7c86d1d

Thesis A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells

Schmieder, Valerie; Novak, Neža; Dhiman, Heena et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells

Authors: Schmieder, Valerie; Novak, Neža; Dhiman, Heena; Nguyen, Ly Ngoc; Serafimova, Evgenija; Klanert, Gerald; Baumann, Martina; Kildegaard, Helene Faustrup; Borth, Nicole

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2952ac8e-767c-4605-811b-710e6cd4ba19

Thesis The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells

Tian, Weihua; Ye, Zilu; Wang, Shengjun et al. · 2019 · University of Copenhagen · DOI

Full title: The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells

Authors: Tian, Weihua; Ye, Zilu; Wang, Shengjun; Schulz, Morten Alder; Van Coillie, Julie; Sun, Lingbo; Chen, Yen-Hsi; Narimatsu, Yoshiki; Hansen, Lars; Kristensen, Claus; Mandel, Ulla; Bennett, Eric Paul; Jabbarzadeh-Tabrizi, Siamak; Schiffmann, Raphael; Shen, Jin-Song; Vakhrushev, Sergey Y.; Clausen, Henrik; Yang, Zhang

Year: 2019

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/3e2a06f8-14f4-4325-8421-d29ab3624404

Thesis The emerging CHO systems biology era: harnessing the ‘omics revolution for biotechnology

Kildegaard, Helene Faustrup; Baycin-Hizal, Deniz; Lewis, Nathan et al. · 2013 · Technical University of Denmark (DTU) · DOI

Full title: The emerging CHO systems biology era: harnessing the ‘omics revolution for biotechnology

Authors: Kildegaard, Helene Faustrup; Baycin-Hizal, Deniz; Lewis, Nathan; Betenbaugh, Michael

Year: 2013

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3d14cbfe-7a58-4483-8e29-db98b61fd906

Thesis A Markov chain model for N-linked protein glycosylation – towards a low-parameter tool for model-driven glycoengineering

Spahn, Philipp N.; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787 et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: A Markov chain model for N-linked protein glycosylation – towards a low-parameter tool for model-driven glycoengineering

Authors: Spahn, Philipp N.; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Hansen, Henning Gram; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Kildegaard, Helene Faustrup; Lewis, Nathan

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4c6e0b4e-131d-4ea4-b2cd-1331877ad8bd

Thesis Targeting miRNAs with CRISPR/Cas9 to Improve Recombinant Protein Production of CHO Cells

Kellner, Kevin; Solanki, Ankur; Amann, Thomas et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Targeting miRNAs with CRISPR/Cas9 to Improve Recombinant Protein Production of CHO Cells

Authors: Kellner, Kevin; Solanki, Ankur; Amann, Thomas; Lao, Nga; Barron, Niall

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/437280a5-1393-422a-9a9d-00f68443909f

Thesis Factors affecting the quality of therapeutic proteins in recombinant Chinese hamster ovary cell culture

Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Kim, Dongil et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Factors affecting the quality of therapeutic proteins in recombinant Chinese hamster ovary cell culture

Authors: Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Kim, Dongil; Kim, Che Lin; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lee, Gyun Min

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/464b29f2-bedf-4a85-b9c3-c061a52c6df4

Thesis Fed-batch CHO cell culture for lab-scale antibody production

Fan, Yuzhou; Ley, Daniel; Andersen, Mikael Rørdam et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Fed-batch CHO cell culture for lab-scale antibody production

Authors: Fan, Yuzhou; Ley, Daniel; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/54dbf94e-f74b-4dd6-a33d-3f93ac979d1d

Thesis Deciphering Cytokine production in CHO cells by Integrating Cell Line Engineering and Omics Strategies

Scapin, Giulia; id_orcid 0000-0002-2978-9549 · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Deciphering Cytokine production in CHO cells by Integrating Cell Line Engineering and Omics Strategies

Authors: Scapin, Giulia; id_orcid 0000-0002-2978-9549

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4d3f74ae-375a-4103-9968-3b362af8aa22

Thesis BiP Inducer X: An ER Stress Inhibitor for Enhancing Recombinant Antibody Production in CHO Cell Culture

Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders H et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: BiP Inducer X: An ER Stress Inhibitor for Enhancing Recombinant Antibody Production in CHO Cell Culture

Authors: Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders H; id_orcid 0000-0002-6007-4787; Kildegaard, Helene Faustrup; Min Lee, Gyun

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4bb8049c-8448-48b2-849a-893bbcc3e831

Thesis Improving Recombinant Antibody Production Using FcBAR: An In Situ Approach to Detect and Amplify Protein-Protein Interactions

Wu, Mina Ying Min; Rocamora, Frances; Samoudi, Mojtaba et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Improving Recombinant Antibody Production Using FcBAR: An In Situ Approach to Detect and Amplify Protein-Protein Interactions

Authors: Wu, Mina Ying Min; Rocamora, Frances; Samoudi, Mojtaba; Robinson, Caressa M.; Kuo, Chih-Chung; Pristovšek, Nuša; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Kildegaard, Helene Faustrup; Lee, Gyun Min; Campos, Alexandre Rosa; Lewis, Nathan E.

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/47083ccf-1089-4f74-b875-790ddbd3f9cf

Thesis Application of CRISPR/Cas9 Genome Editing to Improve Recombinant Protein Production in CHO Cells

Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Rojek, Johan Blatt et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Application of CRISPR/Cas9 Genome Editing to Improve Recombinant Protein Production in CHO Cells

Authors: Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Rojek, Johan Blatt; la Cour Karottki, Karen Julie; Lee, Jae Seong; Kildegaard, Helene Faustrup

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/681c1edc-1d94-47ca-96a9-99e6989a2708

Thesis Minimizing Clonal Variation during Mammalian Cell Line Engineering for Improved Systems Biology Data Generation

Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Sergeeva, Daria et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Minimizing Clonal Variation during Mammalian Cell Line Engineering for Improved Systems Biology Data Generation

Authors: Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Sergeeva, Daria; Lee, Jae Seong; Marín de Mas, Igor; Lewis, Nathan E.; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Nielsen, Lars Keld; Min Lee, Gyun; Kildegaard, Helene Faustrup

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/617f549d-1121-49ca-a9c3-2874643dbc6a

Thesis Impact of cellular stress on recombinant monoclonal antibody produced by high yielding Chinese Hamster Ovary (CHO) cell cultures in bioreactors

Chevallier, Valentine · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Impact of cellular stress on recombinant monoclonal antibody produced by high yielding Chinese Hamster Ovary (CHO) cell cultures in bioreactors

Authors: Chevallier, Valentine

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/563b6ddf-77b7-40a0-94d6-f435d6d8a1ca

Thesis CRISPR/Cas9-mediated genome engineering of CHO cell factories: application and perspectives

Lee, Jae Seong; Grav, Lise Marie; id_orcid 0000-0001-8042-7108 et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: CRISPR/Cas9-mediated genome engineering of CHO cell factories: application and perspectives

Authors: Lee, Jae Seong; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lewis, Nathan E.; Kildegaard, Helene Faustrup

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/52fc8089-3984-4fdf-92ff-f1dff24e34f2

Thesis Unraveling productivity-enhancing genes in Chinese hamster ovary cells via CRISPR activation screening using recombinase-mediated cassette exchange system

Baek, Minhye; Kim, Che Lin; Kim, Su Hyun et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Unraveling productivity-enhancing genes in Chinese hamster ovary cells via CRISPR activation screening using recombinase-mediated cassette exchange system

Authors: Baek, Minhye; Kim, Che Lin; Kim, Su Hyun; la Cour Karottki, Karen Julie; Hefzi, Hooman; id_orcid 0009-0003-4067-6224; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Lewis, Nathan E.; Lee, Jae Seong; Lee, Gyun Min

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4ec45fdf-f45d-42f6-86e6-b494eebc0b2a

Thesis Accelerated Homology-Directed Targeted Integration of Transgenes in Chinese Hamster Ovary Cells Via CRISPR/Cas9 and Fluorescent Enrichment

Lee, Jae Seong; Grav, Lise Marie; id_orcid 0000-0001-8042-7108 et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Accelerated Homology-Directed Targeted Integration of Transgenes in Chinese Hamster Ovary Cells Via CRISPR/Cas9 and Fluorescent Enrichment

Authors: Lee, Jae Seong; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Min Lee, Gyun; Kildegaard, Helene Faustrup

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/574bc003-4903-41b7-ab18-c218319b1350

Thesis Cell culture process dynamics and metabolic flux distributions using hybrid models

Kailasanathan, Rajiv; Sivaram, Abhishek; Mansouri, Seyed Soheil et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Cell culture process dynamics and metabolic flux distributions using hybrid models

Authors: Kailasanathan, Rajiv; Sivaram, Abhishek; Mansouri, Seyed Soheil; id_orcid 0000-0002-0924-4947

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/572e7d61-3351-4ced-b2f5-6b9e4ceab22f

Thesis Developing Tools for Improved and Predictable Recombinant Protein Production in CHO Cells

Pristovšek, Nuša · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Developing Tools for Improved and Predictable Recombinant Protein Production in CHO Cells

Authors: Pristovšek, Nuša

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/64616d27-ec57-4e4b-8166-fddb72ce82e5

Thesis A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes

Karottki, Karen Julie la Cour; Hefzi, Hooman; Li, Songyuan et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes

Authors: Karottki, Karen Julie la Cour; Hefzi, Hooman; Li, Songyuan; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Spahn, Philipp N.; Joshi, Chintan; Ruckerbauer, David; Bort, Juan A.Hernandez; Thomas, Alex; Lee, Jae Seong; Borth, Nicole; Lee, Gyun Min; Kildegaard, Helene Faustrup; Lewis, Nathan E.

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/6c630eef-615d-4310-b404-6413d4cc1932

Thesis The GalNAc-type O-Glycoproteome of CHO Cells Characterized by the SimpleCell Strategy

Zhang, Yang; Halim, Adnan; Narimatsu, Yoshiki et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: The GalNAc-type O-Glycoproteome of CHO Cells Characterized by the SimpleCell Strategy

Authors: Zhang, Yang; Halim, Adnan; Narimatsu, Yoshiki; Jitendra Joshi, Hiren; Steentoft, Catharina; Gram Schjoldager, Katrine Ter-Borch; Alder Schulz, Morten; Sealover, Natalie R.; Kayser, Kevin J.; Paul Bennett, Eric; Levery, Steven B.; Vakhrushev, Sergey Y.; Clausen, Henrik

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5ebfd0ee-130e-4389-ae10-57be9960dab0

Thesis Data-Driven Cell Engineering of Chinese Hamster Ovary Cells through Machine Learning

Zaragoza, Jose Manuel Camacho · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Data-Driven Cell Engineering of Chinese Hamster Ovary Cells through Machine Learning

Authors: Zaragoza, Jose Manuel Camacho

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5ba1a67a-d916-46d2-be02-2dcbaa66a091

Thesis The cell density effect in animal cell-based bioprocessing:Questions, insights and perspectives

Lavado-García, Jesús; Pérez-Rubio, Pol; Cervera, Laura et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: The cell density effect in animal cell-based bioprocessing:Questions, insights and perspectives

Authors: Lavado-García, Jesús; Pérez-Rubio, Pol; Cervera, Laura; Gòdia, Francesc

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/59d319c9-b38b-40f6-a360-60ecc53c3457

Thesis Concomitant consumption of glucose and lactate: A novel batch production process for CHO cells

Martínez-Monge, I.; Comas, P.; Triquell, J. et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Concomitant consumption of glucose and lactate: A novel batch production process for CHO cells

Authors: Martínez-Monge, I.; Comas, P.; Triquell, J.; Casablancas, A.; Lecina, M.; Paredes, C.J.; Cairó, J.J.

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5dbc1c02-f271-4f18-8ccd-422ca2b145c2

Thesis Toward genome-scale models of the Chinese hamster ovary cells: incentives, status and perspectives

Kaas, Christian Schrøder; Fan, Yuzhou; Weilguny, Dietmar et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: Toward genome-scale models of the Chinese hamster ovary cells: incentives, status and perspectives

Authors: Kaas, Christian Schrøder; Fan, Yuzhou; Weilguny, Dietmar; Kristensen, Claus; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/6067dd57-c31e-41f2-9225-4c51754db14a

Thesis From omics to cellular mechanisms in mammalian cell factory development

Samoudi, Mojtaba; Masson, Helen O.; Kuo, Chih Chung et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: From omics to cellular mechanisms in mammalian cell factory development

Authors: Samoudi, Mojtaba; Masson, Helen O.; Kuo, Chih Chung; Robinson, Caressa M.; Lewis, Nathan E.

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5c3710d3-ef35-45bb-8010-f9ba8c882f04

Thesis Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process

Calmels, Cyrielle; McCann, Andréa; Malphettes, Laetitia et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process

Authors: Calmels, Cyrielle; McCann, Andréa; Malphettes, Laetitia; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/59c3f8ac-571d-4312-969f-4d6d5689e961

Thesis Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome.

Lewis, Nathan E; Liu, Xin; Li, Yuxiang et al. · 2013 · Technical University of Denmark (DTU) · DOI

Full title: Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome.

Authors: Lewis, Nathan E; Liu, Xin; Li, Yuxiang; Nagarajan, Harish; Yerganian, George; O'Brien, Edward; Bordbar, Aarash; Roth, Anne M; Rosenbloom, Jeffrey; Bian, Chao; Xie, Min; Chen, Wenbin; Li, Ning; Baycin-Hizal, Deniz; Latif, Haythem; Förster, Jochen; id_orcid 0000-0003-4045-7905; Betenbaugh, Michael; Famili, Iman; Xu, Xun; Wang, Jun; Palsson, Bernhard O; id_orcid 0000-0003-2357-6785

Year: 2013

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5e57cd4b-b567-4bee-9ea3-264e08ac9905

Thesis Development of a VHH-Based Erythropoietin Quantification Assay

Kol, Stefan; Beuchert Kallehauge, Thomas; Adema, Simon et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Development of a VHH-Based Erythropoietin Quantification Assay

Authors: Kol, Stefan; Beuchert Kallehauge, Thomas; Adema, Simon; Hermans, Pim

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/852e0d29-63c5-4251-b2b1-d053b4317987

Thesis Following an Optimal Batch Bioreactor Operations Model

Ibarra-Junquera, V.; Jørgensen, Sten Bay; id_orcid 0000-0002-3179-972X et al. · 2012 · Technical University of Denmark (DTU) · DOI

Full title: Following an Optimal Batch Bioreactor Operations Model

Authors: Ibarra-Junquera, V.; Jørgensen, Sten Bay; id_orcid 0000-0002-3179-972X; Virgen-Ortíz, J.J.; Escalante-Minakata, P.; Osuna-Castro, J.A.

Year: 2012

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7578e107-7ee3-4ba3-b03b-a7507ad16c8a

Thesis Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications

MacDonald, Michael A.; Nöbel, Matthias; Roche Recinos, Dinora et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications

Authors: MacDonald, Michael A.; Nöbel, Matthias; Roche Recinos, Dinora; Martínez, Verónica S.; Schulz, Benjamin L.; Howard, Christopher B.; Baker, Kym; Shave, Evan; Lee, Yih Yean; Marcellin, Esteban; Mahler, Stephen; Nielsen, Lars Keld; Munro, Trent

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/67f5a323-1367-4520-928b-e7b232c33cee

Thesis Multicopy Targeted Integration for Accelerated Development of High-Producing Chinese Hamster Ovary Cells

Sergeeva, Daria; Min Lee, Gyun; Nielsen, Lars Keld et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Multicopy Targeted Integration for Accelerated Development of High-Producing Chinese Hamster Ovary Cells

Authors: Sergeeva, Daria; Min Lee, Gyun; Nielsen, Lars Keld; Grav, Lise Marie; id_orcid 0000-0001-8042-7108

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/71c01a2d-bfaf-4f2b-a221-1ef2dd777ca7

Thesis Classification and Characterization of CHO Cell Lines on the Basis of Transcriptomic Signatures

Singh, Ankita · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Classification and Characterization of CHO Cell Lines on the Basis of Transcriptomic Signatures

Authors: Singh, Ankita

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7c151fcf-538a-4ac4-ad33-c5b284e7ed86

Thesis Using titer and titer normalized to confluence are complementary strategies for obtaining Chinese hamster ovary cell lines with high volumetric productivity of etanercept

Pristovšek, Nuša; Hansen, Henning Gram; Sergeeva, Daria et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Using titer and titer normalized to confluence are complementary strategies for obtaining Chinese hamster ovary cell lines with high volumetric productivity of etanercept

Authors: Pristovšek, Nuša; Hansen, Henning Gram; Sergeeva, Daria; Borth, Nicole; Min Lee, Gyun; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/72821a9b-dd89-40a8-a86e-7f920a10d4ea

Thesis A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering

Liang, Chenguang; Chiang, Austin W. T.; Hansen, Anders H. et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering

Authors: Liang, Chenguang; Chiang, Austin W. T.; Hansen, Anders H.; id_orcid 0000-0002-6007-4787; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Schoffelen, Sanne; id_orcid 0000-0003-2664-8561; Sorrentino, James T.; Kellman, Benjamin P.; Bao, Bokan; Voldborg, Bjørn G.; id_orcid 0000-0002-7005-1642; Lewis, Nathan E.

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/74da1088-d9ca-45bb-bcfb-73e554d9af88

Thesis Multi-omic profiling of EPO producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Multi-omic profiling of EPO producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Authors: Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael; Magdenoska, Olivera; Nielsen, Kristian Fog; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/87a5064f-e2fc-4741-b45c-4def9fbd8a82

Thesis Engineering nutrient and by-product metabolism of CHO cells

Domingues Pereira, Sara Isabel · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Engineering nutrient and by-product metabolism of CHO cells

Authors: Domingues Pereira, Sara Isabel

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/83ef725c-686f-4082-b2ee-cb9e812b6883

Thesis Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation

Nöbel, Matthias; Barry, Craig; MacDonald, Michael A. et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation

Authors: Nöbel, Matthias; Barry, Craig; MacDonald, Michael A.; Baker, Kym; Shave, Evan; Mahler, Stephen; Munro, Trent; Martínez, Verónica S.; Nielsen, Lars K.; Marcellin, Esteban

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7922b2bb-f311-4387-b752-e3faec2f9792

Thesis Dynamics of immature mAb glycoform secretion during CHO cell culture:An integrated modelling framework

Jimenez del Val, Ioscani; Fan, Yuzhou; Weilguny, Dietmar · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Dynamics of immature mAb glycoform secretion during CHO cell culture:An integrated modelling framework

Authors: Jimenez del Val, Ioscani; Fan, Yuzhou; Weilguny, Dietmar

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/72c9b07b-bd9a-42e9-a3f7-c0b8ae0aedf6

Thesis Accelerating Genome Editing in CHO Cells Using CRISPR Cas9 and CRISPy, a Web-Based Target Finding Tool

Ronda, Carlotta; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: Accelerating Genome Editing in CHO Cells Using CRISPR Cas9 and CRISPy, a Web-Based Target Finding Tool

Authors: Ronda, Carlotta; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Hansen, Henning Gram; Beuchert Kallehauge, Thomas; Betenbaugh, Michael; Nielsen, Alex Toftgaard; Kildegaard, Helene Faustrup

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/83aa80e2-8128-4c3f-a2a8-b38be50b53ab

Thesis Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

Fan, Yuzhou; Jimenez Del Val, Ioscani; Müller, Christian et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

Authors: Fan, Yuzhou; Jimenez Del Val, Ioscani; Müller, Christian; Wagtberg Sen, Jette; Rasmussen, Søren Kofoed; Kontoravdi, Cleo; Weilguny, Dietmar; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7390e534-3558-4a15-a8c1-359cc5555270

Thesis BCAT1 and BCAT2 disruption in CHO cells has cell line-dependent effects

Pereira, Sara; Ley, Daniel; Schubert, Mikkel et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: BCAT1 and BCAT2 disruption in CHO cells has cell line-dependent effects

Authors: Pereira, Sara; Ley, Daniel; Schubert, Mikkel; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7faa5a66-7114-41e8-a5cc-88f11ee0bba3

Thesis Methods for modeling chinese hamster ovary (cho) cell metabolism.

Herrgard, Markus; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Methods for modeling chinese hamster ovary (cho) cell metabolism.

Authors: Herrgard, Markus; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Lewis, Nathan E.; Bruntse, Anders Bech

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/8529ad64-19cf-4add-99cf-9bf74dc64238

Thesis Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells

Pérez-Rodriguez, Saumel; Wulff, Tune; Voldborg, Bjørn G et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells

Authors: Pérez-Rodriguez, Saumel; Wulff, Tune; Voldborg, Bjørn G; id_orcid 0000-0002-7005-1642; Altamirano, Claudia; Trujillo-Roldán, Mauricio A; Valdez-Cruz, Norma A

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7e0744e3-e93e-4664-9482-32419e18ecac

Thesis Process analytical technology (PAT) for biopharmaceuticals

Glassey, Jarka; Gernaey, Krist; id_orcid 0000-0002-0364-1773 et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: Process analytical technology (PAT) for biopharmaceuticals

Authors: Glassey, Jarka; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Clemens, Christoph; Schulz, Torsten W.; Oliveira, Rui; Striedner, Gerald; Mandenius, Carl-Fredrik

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/88d90c02-087c-4518-9755-d49fd4b0cabd

Thesis Why is batch processing still dominating the biologics landscape? Towards an integrated continuous bioprocessing alternative

Kumar, Ashish; Udugama, Isuru A.; Gargalo, Carina L. et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Why is batch processing still dominating the biologics landscape? Towards an integrated continuous bioprocessing alternative

Authors: Kumar, Ashish; Udugama, Isuru A.; Gargalo, Carina L.; id_orcid 0000-0002-8740-9591; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7f1d4f70-3946-4a73-8809-241bc136ce8c

Thesis Lactate reduction in CHO cell cultures through metabolic analysis

Monge, Ivan Martinez; Hefzi, Hooman; Sanchez, Pere Comas et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Lactate reduction in CHO cell cultures through metabolic analysis

Authors: Monge, Ivan Martinez; Hefzi, Hooman; Sanchez, Pere Comas; Marín de Mas, Igor Batolomé; Decker, Marianne; Lecina, Martí; Cairó, Jordi Joan; Lewis, Nathan; Nielsen, Lars Keld

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/88a705b5-5f0e-40b9-b8ca-455e124be964

Thesis Accelerated and Rational Design of Improved CHO Cell Factories

Grav, Lise Marie; id_orcid 0000-0001-8042-7108 · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Accelerated and Rational Design of Improved CHO Cell Factories

Authors: Grav, Lise Marie; id_orcid 0000-0001-8042-7108

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a3024744-4f4a-4692-855c-e76aad3c77fc

Thesis RNA-Seq Highlights High Clonal Variation in Monoclonal Antibody Producing CHO Cells

Orellana, Camila A.; Marcellin, Esteban; Palfreyman, Robin W. et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: RNA-Seq Highlights High Clonal Variation in Monoclonal Antibody Producing CHO Cells

Authors: Orellana, Camila A.; Marcellin, Esteban; Palfreyman, Robin W.; Munro, Trent P.; Gray, Peter P.; Nielsen, Lars K.

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9c163db5-1757-4d8d-b0ec-6ea8bdfdf885

Thesis Deep sequencing reveals different compositions of mRNA transcribed from the F8 gene in a panel of FVIII-producing CHO cell lines

Kaas, Christian Schrøder; Bolt, Gert; Hansen, Jens J et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Deep sequencing reveals different compositions of mRNA transcribed from the F8 gene in a panel of FVIII-producing CHO cell lines

Authors: Kaas, Christian Schrøder; Bolt, Gert; Hansen, Jens J; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kristensen, Claus

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9c8c6758-0da6-42f9-bbd4-a8b4230291b9

Thesis Quantitative feature extraction from the Chinese hamster ovary bioprocess bibliome using a novel meta-analysis workflow

Golabgir, Aydin; Gutierrez, Jahir M.; Hefzi, Hooman et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Quantitative feature extraction from the Chinese hamster ovary bioprocess bibliome using a novel meta-analysis workflow

Authors: Golabgir, Aydin; Gutierrez, Jahir M.; Hefzi, Hooman; Li, Shangzhong; Palsson, Bernhard; id_orcid 0000-0003-2357-6785; Herwig, Christoph; Lewis, Nathan

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/8c007ce6-63c9-424a-85ac-4bab6a21e5f7

Thesis Dynamic Optimization for Monoclonal Antibody Production

Kaysfeld, Morten Wahlgreen; Kumar, Deepak; Nielsen, Marcus Krogh et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Dynamic Optimization for Monoclonal Antibody Production

Authors: Kaysfeld, Morten Wahlgreen; Kumar, Deepak; Nielsen, Marcus Krogh; Jørgensen, John Bagterp; id_orcid 0000-0001-9799-2808

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9ff2d615-438b-414d-a0e2-29da79c7a72c

Thesis Bioprocess facility for test of Engineered CHO cell lines in Single-use bioreactors

Decker, Marianne; Lund Jensen, Kristian; Javidi, Elham Maria et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Bioprocess facility for test of Engineered CHO cell lines in Single-use bioreactors

Authors: Decker, Marianne; Lund Jensen, Kristian; Javidi, Elham Maria; Voldborg, Bjørn Gunnar; id_orcid 0000-0002-7005-1642

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/99b1c9d0-42ef-4cee-b68e-d45bbaae761d

Thesis Mixing four Cell lines to produce an Antibody cocktail as a Next-generation antivenom - a Case study with a “mixed” Outcome

Christina Adams, Anna · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Mixing four Cell lines to produce an Antibody cocktail as a Next-generation antivenom - a Case study with a “mixed” Outcome

Authors: Christina Adams, Anna

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9b2942d6-7767-4e89-848f-d85b5d4dc44f

Thesis New developments in online OUR monitoring and its application to animal cell cultures

Martínez-Monge, I; Roman, R.; Comas, P. et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: New developments in online OUR monitoring and its application to animal cell cultures

Authors: Martínez-Monge, I; Roman, R.; Comas, P.; Fontova, A.; Lecina, M.; Casablancas, A.; Cairó, J J

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/8986a5a2-6603-4730-bb85-0c9865f51e7b

Thesis CHOmics:A web-based tool for multi-omics data analysis and interactive visualization in CHO cell lines

Lin, Dongdong; Yalamanchili, Hima B.; Zhang, Xinmin et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: CHOmics:A web-based tool for multi-omics data analysis and interactive visualization in CHO cell lines

Authors: Lin, Dongdong; Yalamanchili, Hima B.; Zhang, Xinmin; Lewis, Nathan E.; Alves, Christina S.; Groot, Joost; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Bjørn, Sara P.; id_orcid 0000-0003-3341-6160; Wulff, Tune; Voldborg, Bjørn G.; id_orcid 0000-0002-7005-1642; Zhou, Yizhou; Zhang, Baohong

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9e317d9d-c2fd-470d-b8fc-a27d29192c9b

Thesis Elucidation of the CHO Super-Ome (CHO-SO) by Proteoinformatics

Kumar, Amit; Baycin-Hizal, Deniz; Wolozny, Daniel et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Elucidation of the CHO Super-Ome (CHO-SO) by Proteoinformatics

Authors: Kumar, Amit; Baycin-Hizal, Deniz; Wolozny, Daniel; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Lewis, Nathan; Heffner, Kelley; Chaerkady, Raghothama; Cole, Robert N.; Shiloach, Joseph; Zhang, Hui; Bowen, Michael A.; Betenbaugh, Michael J.

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9d841c9b-1302-4b62-b81d-5087d0e2af07

Thesis N-Glycan analysis and engineering

Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787 · 2019 · Technical University of Denmark (DTU) · DOI

Full title: N-Glycan analysis and engineering

Authors: Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/abbd63ce-ce1d-455f-804f-20b718c3f892

Thesis One-step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment.

Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lee, Jae Seong et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: One-step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment.

Authors: Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lee, Jae Seong; Thomsen, Signe Gerling; Beuchert Kallehauge, Thomas; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Min Lee, Gyun; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Kildegaard, Helene Faustrup

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b3efc1f4-1970-4875-9462-c26194b49667

Thesis Developing tools for rational engineering of the secretory pathway in CHO cells

Rojek, Johan Blatt · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Developing tools for rational engineering of the secretory pathway in CHO cells

Authors: Rojek, Johan Blatt

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9dbfc2d8-4ee1-456f-9618-91c7ffe7c490

Thesis Direct quality control of glycoengineered erythropoietin variants

Čaval, Tomislav; Tian, Weihua; Yang, Zhang et al. · 2018 · University of Copenhagen · DOI

Full title: Direct quality control of glycoengineered erythropoietin variants

Authors: Čaval, Tomislav; Tian, Weihua; Yang, Zhang; Clausen, Henrik; Heck, Albert J.R.

Year: 2018

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/9ed5fa5c-46e4-4485-8d42-2454f8bedb5f

Thesis ‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells

Orellana, Camila A.; Martínez, Verónica S.; MacDonald, Michael A. et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: ‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells

Authors: Orellana, Camila A.; Martínez, Verónica S.; MacDonald, Michael A.; Henry, Matthew N.; Gillard, Marianne; Gray, Peter P.; Nielsen, Lars K.; Mahler, Stephen; Marcellin, Esteban

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/acf785a5-65ae-4eae-bd29-e37f42319ac1

Thesis Multi-omic profiling of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Multi-omic profiling of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Authors: Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael; Magdenoska, Olivera; Nielsen, Kristian Fog; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b2905a68-9052-41ca-b6f7-6cb30d6b56c5

Thesis Increased mAb production in amplified CHO cell lines is associated with increased interaction of CREB1 with transgene promoter

Dahodwala, Hussain; Kaushik, Prashant; Tejwani, Vijay et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Increased mAb production in amplified CHO cell lines is associated with increased interaction of CREB1 with transgene promoter

Authors: Dahodwala, Hussain; Kaushik, Prashant; Tejwani, Vijay; Chung Kuo, Chih; Ménard, Patrice; Henry, Michael; Voldborg, Bjørn G.; id_orcid 0000-0002-7005-1642; Lewis, Nathan E.; Meleady, Paula; Sharfstein, Susan T.

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ad0715a7-895d-4736-8553-188b40a57fe4

Thesis Modeling and Simulation of Upstream and Downstream Processes for Monoclonal Antibody Production

Wahlgreen, Morten Ryberg; Meyer, Kristian; Ritschel, Tobias K.S. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Modeling and Simulation of Upstream and Downstream Processes for Monoclonal Antibody Production

Authors: Wahlgreen, Morten Ryberg; Meyer, Kristian; Ritschel, Tobias K.S.; id_orcid 0000-0002-5843-240X; Engsig-Karup, Allan Peter; id_orcid 0000-0001-8626-1575; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Jørgensen, John Bagterp; id_orcid 0000-0001-9799-2808

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bee80c6c-737f-485c-a10c-8b202794086b

Thesis Development of dynamic compartment models for industrial aerobic fed-batch fermentation processes

Nadal-Rey, Gisela; McClure, Dale D.; Kavanagh, John M. et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Development of dynamic compartment models for industrial aerobic fed-batch fermentation processes

Authors: Nadal-Rey, Gisela; McClure, Dale D.; Kavanagh, John M.; Cassells, Benny; Cornelissen, Sjef; Fletcher, David F.; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b13c2130-8a91-421a-9095-93064cac393c

Thesis Comparison of spectroscopy technologies for improved monitoring of cell culture processes in miniature bioreactors

Rowland-Jones, Ruth C.; van der Berg, Franciscus Winfried J; Racher, Andrew J. et al. · 2017 · University of Copenhagen · DOI

Full title: Comparison of spectroscopy technologies for improved monitoring of cell culture processes in miniature bioreactors

Authors: Rowland-Jones, Ruth C.; van der Berg, Franciscus Winfried J; Racher, Andrew J.; Martin, Elaine B.; Jaques, Colin

Year: 2017

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/b0ba0d28-f1e5-4abb-be69-231b4094c928

Thesis Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity

Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity

Authors: Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Kildegaard, Helene Faustrup; Min Lee, Gyun

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b93398cc-7060-452d-87ce-fc9c3bf95dd0

Thesis Biopharmaceutical Process – Contract Development Organization: Startup

Chaffkin, Andrew; Headberg, Melissa; Jacobovitz, Louise et al. · 2023 · University of Pennsylvania · DOI

Full title: Biopharmaceutical Process – Contract Development Organization: Startup

Authors: Chaffkin, Andrew; Headberg, Melissa; Jacobovitz, Louise; Louie, Matthew

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/5964

Thesis The effect of in vitro culture conditions on cell metabolism

Hartley, F · 2018 · University of Oxford - ORA · DOI

Full title: The effect of in vitro culture conditions on cell metabolism

Authors: Hartley, F

Year: 2018

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:160ef4ac-b599-49db-97dc-f820b5cdb61f

Thesis Trends and approaches in N-Glycosylation engineering in Chinese hamster ovary cell culture

Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Trends and approaches in N-Glycosylation engineering in Chinese hamster ovary cell culture

Authors: Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1218be93-6eab-4722-851d-4378a47b79ee

Thesis Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production

Henry, Matthew N.; MacDonald, Michael A.; Orellana, Camila A. et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production

Authors: Henry, Matthew N.; MacDonald, Michael A.; Orellana, Camila A.; Gray, Peter P.; Gillard, Marianne; Baker, Kym; Nielsen, Lars K.; Marcellin, Esteban; Mahler, Stephen; Martínez, Verónica S.

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1326a05c-2af7-46f4-95fd-090bc436b967

Thesis N-Glycosylation optimization of recombinant antibodies in CHO cell through process and metabolic engineering

Fan, Yuzhou · 2015 · Technical University of Denmark (DTU) · DOI

Full title: N-Glycosylation optimization of recombinant antibodies in CHO cell through process and metabolic engineering

Authors: Fan, Yuzhou

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0d46b1c0-0617-4c4e-8295-079e1eddaf3e

Thesis A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

Fan, Yuzhou; Jimenez Del Val, Ioscani; Müller, Christian et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/032ff7ec-9b40-4a61-8f15-f7c40fa6a14e

Thesis Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers

Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers

Authors: Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem; Malphettes, Laetitia; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/07c1b78f-8e1b-4264-8b5a-d74f261ebab9

Thesis Trends and approaches in N-Glycosylation engineering in Chinese hamster ovary cell culture

Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Trends and approaches in N-Glycosylation engineering in Chinese hamster ovary cell culture

Authors: Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/05f81555-5e37-4d88-be11-678eda3ec16b

Thesis Single-Batch Expression of an Experimental Recombinant Snakebite Antivenom Based on an Oligoclonal Mixture of Human Monoclonal Antibodies

Adams, Anna C.; Grav, Lise M.; id_orcid 0000-0001-8042-7108 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Single-Batch Expression of an Experimental Recombinant Snakebite Antivenom Based on an Oligoclonal Mixture of Human Monoclonal Antibodies

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1cacecb6-2d02-484b-8855-606d116d8855

Thesis Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells

Saghaleyni, Rasool; Malm, Magdalena; Moruzzi, Noah et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2d7082ac-461c-4bfd-9506-aee94ce2430e

Thesis A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells

Schmieder, Valerie; Novak, Neža; Dhiman, Heena et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells

Authors: Schmieder, Valerie; Novak, Neža; Dhiman, Heena; Nguyen, Ly Ngoc; Serafimova, Evgenija; Klanert, Gerald; Baumann, Martina; Kildegaard, Helene Faustrup; Borth, Nicole

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2952ac8e-767c-4605-811b-710e6cd4ba19

Thesis Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing

Lee, Jae Seong; Park, Jin Hyoung; Kwang Ha, Tae et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0ae89c9f-9a27-4554-a9b0-2af9aa0614a9

Thesis Glycoengineering in CHO cells: Advances in systems biology

Tejwani, Vijay; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808 et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Glycoengineering in CHO cells: Advances in systems biology

Authors: Tejwani, Vijay; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Nam, Jong Hyun; Sharfstein, Susan T

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/18d1eb12-342d-4d7e-bfaa-aad1a918cc13

Thesis CHO On A Detox: Removing By-Product Formation Through Cell Engineering

Pereira, Sara; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: CHO On A Detox: Removing By-Product Formation Through Cell Engineering

Authors: Pereira, Sara; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/16746af6-dbf5-46ee-a6a0-d5c8bf3c3b88

Thesis Method for reducing ammonium and lactate production in cho cells

Ley, Daniel; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808 et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Method for reducing ammonium and lactate production in cho cells

Authors: Ley, Daniel; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2eca9af1-d5e3-427f-a8d4-142c07400b20

Thesis A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism

Hefzi, Hooman; Ang, Kok Siong; Hanscho, Michael et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2f8bb3cd-eb0c-46f7-b39b-3791d7c86d1d

Thesis Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process

Calmels, Cyrielle; McCann, Andréa; Malphettes, Laetitia et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process

Authors: Calmels, Cyrielle; McCann, Andréa; Malphettes, Laetitia; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/59c3f8ac-571d-4312-969f-4d6d5689e961

Thesis Cell culture process dynamics and metabolic flux distributions using hybrid models

Kailasanathan, Rajiv; Sivaram, Abhishek; Mansouri, Seyed Soheil et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Cell culture process dynamics and metabolic flux distributions using hybrid models

Authors: Kailasanathan, Rajiv; Sivaram, Abhishek; Mansouri, Seyed Soheil; id_orcid 0000-0002-0924-4947

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/572e7d61-3351-4ced-b2f5-6b9e4ceab22f

Thesis Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

Pereira, Sara; Kildegaard, Helene F.; Andersen, Mikael R. et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

Authors: Pereira, Sara; Kildegaard, Helene F.; Andersen, Mikael R.; id_orcid 0000-0003-4794-6808

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/28b6ee0a-2f57-47f3-ba14-6a113e9c7800

Thesis Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Hansen, Henning Gram; Nilsson, Claes Nymand; Lund, Anne Mathilde et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/41719bc3-f624-40be-ba5e-4449c22aac7f

Thesis Deciphering Cytokine production in CHO cells by Integrating Cell Line Engineering and Omics Strategies

Scapin, Giulia; id_orcid 0000-0002-2978-9549 · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Deciphering Cytokine production in CHO cells by Integrating Cell Line Engineering and Omics Strategies

Authors: Scapin, Giulia; id_orcid 0000-0002-2978-9549

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4d3f74ae-375a-4103-9968-3b362af8aa22

Thesis BiP Inducer X: An ER Stress Inhibitor for Enhancing Recombinant Antibody Production in CHO Cell Culture

Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders H et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: BiP Inducer X: An ER Stress Inhibitor for Enhancing Recombinant Antibody Production in CHO Cell Culture

Authors: Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders H; id_orcid 0000-0002-6007-4787; Kildegaard, Helene Faustrup; Min Lee, Gyun

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4bb8049c-8448-48b2-849a-893bbcc3e831

Thesis A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

Lund, Anne Mathilde; Kildegaard, Helene Faustrup; Petersen, Maja Borup Kjær et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1e6b9cdd-536a-420a-b808-622781069950

Thesis Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Martínez-Monge, I.; Martínez, C.; Decker, M. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Authors: Martínez-Monge, I.; Martínez, C.; Decker, M.; Udugama, I. A.; Marín de Mas, I.; Gernaey, K. V.; id_orcid 0000-0002-0364-1773; Nielsen, L. K.

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3b1685d4-5ab9-4737-b414-d28fecf9b9eb

Thesis A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering

Liang, Chenguang; Chiang, Austin W. T.; Hansen, Anders H. et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/74da1088-d9ca-45bb-bcfb-73e554d9af88

Thesis The GalNAc-type O-Glycoproteome of CHO Cells Characterized by the SimpleCell Strategy

Zhang, Yang; Halim, Adnan; Narimatsu, Yoshiki et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: The GalNAc-type O-Glycoproteome of CHO Cells Characterized by the SimpleCell Strategy

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5ebfd0ee-130e-4389-ae10-57be9960dab0

Thesis Multicopy Targeted Integration for Accelerated Development of High-Producing Chinese Hamster Ovary Cells

Sergeeva, Daria; Min Lee, Gyun; Nielsen, Lars Keld et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Multicopy Targeted Integration for Accelerated Development of High-Producing Chinese Hamster Ovary Cells

Authors: Sergeeva, Daria; Min Lee, Gyun; Nielsen, Lars Keld; Grav, Lise Marie; id_orcid 0000-0001-8042-7108

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/71c01a2d-bfaf-4f2b-a221-1ef2dd777ca7

Thesis Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome.

Lewis, Nathan E; Liu, Xin; Li, Yuxiang et al. · 2013 · Technical University of Denmark (DTU) · DOI

Full title: Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome.

Year: 2013

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5e57cd4b-b567-4bee-9ea3-264e08ac9905

Thesis Data-Driven Cell Engineering of Chinese Hamster Ovary Cells through Machine Learning

Zaragoza, Jose Manuel Camacho · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Data-Driven Cell Engineering of Chinese Hamster Ovary Cells through Machine Learning

Authors: Zaragoza, Jose Manuel Camacho

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5ba1a67a-d916-46d2-be02-2dcbaa66a091

Thesis Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells

Pérez-Rodriguez, Saumel; Wulff, Tune; Voldborg, Bjørn G et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells

Authors: Pérez-Rodriguez, Saumel; Wulff, Tune; Voldborg, Bjørn G; id_orcid 0000-0002-7005-1642; Altamirano, Claudia; Trujillo-Roldán, Mauricio A; Valdez-Cruz, Norma A

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7e0744e3-e93e-4664-9482-32419e18ecac

Thesis Impact of cellular stress on recombinant monoclonal antibody produced by high yielding Chinese Hamster Ovary (CHO) cell cultures in bioreactors

Chevallier, Valentine · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Impact of cellular stress on recombinant monoclonal antibody produced by high yielding Chinese Hamster Ovary (CHO) cell cultures in bioreactors

Authors: Chevallier, Valentine

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/563b6ddf-77b7-40a0-94d6-f435d6d8a1ca

Thesis Methods for modeling chinese hamster ovary (cho) cell metabolism.

Herrgard, Markus; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Methods for modeling chinese hamster ovary (cho) cell metabolism.

Authors: Herrgard, Markus; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Lewis, Nathan E.; Bruntse, Anders Bech

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/8529ad64-19cf-4add-99cf-9bf74dc64238

Thesis Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation

Nöbel, Matthias; Barry, Craig; MacDonald, Michael A. et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation

Authors: Nöbel, Matthias; Barry, Craig; MacDonald, Michael A.; Baker, Kym; Shave, Evan; Mahler, Stephen; Munro, Trent; Martínez, Verónica S.; Nielsen, Lars K.; Marcellin, Esteban

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7922b2bb-f311-4387-b752-e3faec2f9792

Thesis The cell density effect in animal cell-based bioprocessing:Questions, insights and perspectives

Lavado-García, Jesús; Pérez-Rubio, Pol; Cervera, Laura et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: The cell density effect in animal cell-based bioprocessing:Questions, insights and perspectives

Authors: Lavado-García, Jesús; Pérez-Rubio, Pol; Cervera, Laura; Gòdia, Francesc

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/59d319c9-b38b-40f6-a360-60ecc53c3457

Thesis Dynamics of immature mAb glycoform secretion during CHO cell culture:An integrated modelling framework

Jimenez del Val, Ioscani; Fan, Yuzhou; Weilguny, Dietmar · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Dynamics of immature mAb glycoform secretion during CHO cell culture:An integrated modelling framework

Authors: Jimenez del Val, Ioscani; Fan, Yuzhou; Weilguny, Dietmar

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/72c9b07b-bd9a-42e9-a3f7-c0b8ae0aedf6

Thesis Developing Tools for Improved and Predictable Recombinant Protein Production in CHO Cells

Pristovšek, Nuša · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Developing Tools for Improved and Predictable Recombinant Protein Production in CHO Cells

Authors: Pristovšek, Nuša

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/64616d27-ec57-4e4b-8166-fddb72ce82e5

Thesis Classification and Characterization of CHO Cell Lines on the Basis of Transcriptomic Signatures

Singh, Ankita · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Classification and Characterization of CHO Cell Lines on the Basis of Transcriptomic Signatures

Authors: Singh, Ankita

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7c151fcf-538a-4ac4-ad33-c5b284e7ed86

Thesis Expression of antibody fragments in Saccharomyces cerevisiae strains evolved for enhanced protein secretion

Wang, Yanyan; Li, Xiaowei; Chen, Xin et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Expression of antibody fragments in Saccharomyces cerevisiae strains evolved for enhanced protein secretion

Authors: Wang, Yanyan; Li, Xiaowei; Chen, Xin; Nielsen, Jens; Petranovic, Dina; Siewers, Verena

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7f70d6dd-3490-4db7-be9b-c8be2d8f8e8f

Thesis Engineering nutrient and by-product metabolism of CHO cells

Domingues Pereira, Sara Isabel · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Engineering nutrient and by-product metabolism of CHO cells

Authors: Domingues Pereira, Sara Isabel

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/83ef725c-686f-4082-b2ee-cb9e812b6883

Thesis Using titer and titer normalized to confluence are complementary strategies for obtaining Chinese hamster ovary cell lines with high volumetric productivity of etanercept

Pristovšek, Nuša; Hansen, Henning Gram; Sergeeva, Daria et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Using titer and titer normalized to confluence are complementary strategies for obtaining Chinese hamster ovary cell lines with high volumetric productivity of etanercept

Authors: Pristovšek, Nuša; Hansen, Henning Gram; Sergeeva, Daria; Borth, Nicole; Min Lee, Gyun; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/72821a9b-dd89-40a8-a86e-7f920a10d4ea

Thesis Process analytical technology (PAT) for biopharmaceuticals

Glassey, Jarka; Gernaey, Krist; id_orcid 0000-0002-0364-1773 et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: Process analytical technology (PAT) for biopharmaceuticals

Authors: Glassey, Jarka; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Clemens, Christoph; Schulz, Torsten W.; Oliveira, Rui; Striedner, Gerald; Mandenius, Carl-Fredrik

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/88d90c02-087c-4518-9755-d49fd4b0cabd

Thesis CRISPR/Cas9-multiplexed editing of Chinese hamster ovary B4Gal-T1, 2, 3 and 4 Tailors N -Glycan Profiles of Therapeutics and Secreted Host Cell Proteins

Amann, Thomas; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787 et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: CRISPR/Cas9-multiplexed editing of Chinese hamster ovary B4Gal-T1, 2, 3 and 4 Tailors N -Glycan Profiles of Therapeutics and Secreted Host Cell Proteins

Authors: Amann, Thomas; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Min Lee, Gyun; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9615dda9-824f-44dc-945a-6dbf6dc22600

Thesis Development of a VHH-Based Erythropoietin Quantification Assay

Kol, Stefan; Beuchert Kallehauge, Thomas; Adema, Simon et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Development of a VHH-Based Erythropoietin Quantification Assay

Authors: Kol, Stefan; Beuchert Kallehauge, Thomas; Adema, Simon; Hermans, Pim

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/852e0d29-63c5-4251-b2b1-d053b4317987

Thesis Deep sequencing reveals different compositions of mRNA transcribed from the F8 gene in a panel of FVIII-producing CHO cell lines

Kaas, Christian Schrøder; Bolt, Gert; Hansen, Jens J et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Deep sequencing reveals different compositions of mRNA transcribed from the F8 gene in a panel of FVIII-producing CHO cell lines

Authors: Kaas, Christian Schrøder; Bolt, Gert; Hansen, Jens J; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kristensen, Claus

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9c8c6758-0da6-42f9-bbd4-a8b4230291b9

Thesis Multi-omic profiling of EPO producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Multi-omic profiling of EPO producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Authors: Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael; Magdenoska, Olivera; Nielsen, Kristian Fog; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/87a5064f-e2fc-4741-b45c-4def9fbd8a82

Thesis Developing tools for rational engineering of the secretory pathway in CHO cells

Rojek, Johan Blatt · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Developing tools for rational engineering of the secretory pathway in CHO cells

Authors: Rojek, Johan Blatt

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9dbfc2d8-4ee1-456f-9618-91c7ffe7c490

Thesis Navigating biomanufacturing challenges in the use of CHO cells for recombinant adeno-associated virus production

Tatjer, David Catalán; id_orcid 0000-0002-0900-9912 · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Navigating biomanufacturing challenges in the use of CHO cells for recombinant adeno-associated virus production

Authors: Tatjer, David Catalán; id_orcid 0000-0002-0900-9912

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9209d5ce-66e5-452d-9d20-a94da77a0102

Thesis Dynamic Optimization for Monoclonal Antibody Production

Kaysfeld, Morten Wahlgreen; Kumar, Deepak; Nielsen, Marcus Krogh et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Dynamic Optimization for Monoclonal Antibody Production

Authors: Kaysfeld, Morten Wahlgreen; Kumar, Deepak; Nielsen, Marcus Krogh; Jørgensen, John Bagterp; id_orcid 0000-0001-9799-2808

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9ff2d615-438b-414d-a0e2-29da79c7a72c

Thesis Bioprocess facility for test of Engineered CHO cell lines in Single-use bioreactors

Decker, Marianne; Lund Jensen, Kristian; Javidi, Elham Maria et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Bioprocess facility for test of Engineered CHO cell lines in Single-use bioreactors

Authors: Decker, Marianne; Lund Jensen, Kristian; Javidi, Elham Maria; Voldborg, Bjørn Gunnar; id_orcid 0000-0002-7005-1642

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/99b1c9d0-42ef-4cee-b68e-d45bbaae761d

Thesis Accelerated and Rational Design of Improved CHO Cell Factories

Grav, Lise Marie; id_orcid 0000-0001-8042-7108 · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Accelerated and Rational Design of Improved CHO Cell Factories

Authors: Grav, Lise Marie; id_orcid 0000-0001-8042-7108

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a3024744-4f4a-4692-855c-e76aad3c77fc

Thesis Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

Noh, Soo Min; Shin, Seunghyeon; Min Lee, Gyun · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

Authors: Noh, Soo Min; Shin, Seunghyeon; Min Lee, Gyun

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c3748c8e-d76f-40e3-8fcb-c291becc3057

Thesis ‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells

Orellana, Camila A.; Martínez, Verónica S.; MacDonald, Michael A. et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: ‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells

Authors: Orellana, Camila A.; Martínez, Verónica S.; MacDonald, Michael A.; Henry, Matthew N.; Gillard, Marianne; Gray, Peter P.; Nielsen, Lars K.; Mahler, Stephen; Marcellin, Esteban

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/acf785a5-65ae-4eae-bd29-e37f42319ac1

Thesis Multi-omic profiling of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Multi-omic profiling of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Authors: Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael; Magdenoska, Olivera; Nielsen, Kristian Fog; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b2905a68-9052-41ca-b6f7-6cb30d6b56c5

Thesis Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity

Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity

Authors: Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Kildegaard, Helene Faustrup; Min Lee, Gyun

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b93398cc-7060-452d-87ce-fc9c3bf95dd0

Thesis CHOmics:A web-based tool for multi-omics data analysis and interactive visualization in CHO cell lines

Lin, Dongdong; Yalamanchili, Hima B.; Zhang, Xinmin et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: CHOmics:A web-based tool for multi-omics data analysis and interactive visualization in CHO cell lines

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9e317d9d-c2fd-470d-b8fc-a27d29192c9b

Thesis Model-based analysis of N-glycosylation in Chinese hamster ovary cells

Krambeck, Frederick J.; Bennun, Sandra V; Andersen, Mikael Rørdam et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Model-based analysis of N-glycosylation in Chinese hamster ovary cells

Authors: Krambeck, Frederick J.; Bennun, Sandra V; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Betenbaugh, Michael J.

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b07b66c3-9b3c-42d5-8350-78cf6f0092cb

Thesis N-Glycan analysis and engineering

Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787 · 2019 · Technical University of Denmark (DTU) · DOI

Full title: N-Glycan analysis and engineering

Authors: Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/abbd63ce-ce1d-455f-804f-20b718c3f892

Thesis Mixing four Cell lines to produce an Antibody cocktail as a Next-generation antivenom - a Case study with a “mixed” Outcome

Christina Adams, Anna · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Mixing four Cell lines to produce an Antibody cocktail as a Next-generation antivenom - a Case study with a “mixed” Outcome

Authors: Christina Adams, Anna

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9b2942d6-7767-4e89-848f-d85b5d4dc44f

Thesis Modeling and Simulation of Upstream and Downstream Processes for Monoclonal Antibody Production

Wahlgreen, Morten Ryberg; Meyer, Kristian; Ritschel, Tobias K.S. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Modeling and Simulation of Upstream and Downstream Processes for Monoclonal Antibody Production

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bee80c6c-737f-485c-a10c-8b202794086b

Thesis Multi-omic profiling of EPO-producing CHO cell panel reveals metabolic adaptation to heterologous protein production

Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Multi-omic profiling of EPO-producing CHO cell panel reveals metabolic adaptation to heterologous protein production

Authors: Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael; Magdenoska, Olivera; Nielsen, Kristian Fog; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ae3826c0-e867-44cc-af52-550e11e0c5a4

Thesis Evaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration

Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Kumar Ganesan, Saravana et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Evaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration

Authors: Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Kumar Ganesan, Saravana; Martínez-Monje, Iván; Grav, Lise M.; id_orcid 0000-0001-8042-7108; Lavado-García, Jesús; Nielsen, Lars K.

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c72a6084-3783-4f79-b07b-6c0d4b2e6fdb

Thesis Increased mAb production in amplified CHO cell lines is associated with increased interaction of CREB1 with transgene promoter

Dahodwala, Hussain; Kaushik, Prashant; Tejwani, Vijay et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Increased mAb production in amplified CHO cell lines is associated with increased interaction of CREB1 with transgene promoter

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ad0715a7-895d-4736-8553-188b40a57fe4

Thesis Early-Stage In Silico Flowsheet Analysis for a Monoclonal Antibody Platform

Kaiser, Johann; id_orcid 0000-0002-1383-6531; Babi, Deenesh K. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Early-Stage In Silico Flowsheet Analysis for a Monoclonal Antibody Platform

Authors: Kaiser, Johann; id_orcid 0000-0002-1383-6531; Babi, Deenesh K.; Pinelo, Manuel; id_orcid 0000-0002-3944-6144; Krühne, Ulrich; id_orcid 0000-0001-7774-7442

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c3fbbf6b-2d0e-43ac-9387-8537778ebc8f

Thesis Expanding the CRISPR Toolbox for Chinese Hamster Ovary Cell Line Engineering

Julie la Cour Karottki, Karen · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Expanding the CRISPR Toolbox for Chinese Hamster Ovary Cell Line Engineering

Authors: Julie la Cour Karottki, Karen

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d08e2c40-059b-4d60-af81-5dcae6b7155e

Thesis Method of designing carbohydrates

Lewis, Nathan; Chiang, Wan-Tien; Liang, Chenguang · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Method of designing carbohydrates

Authors: Lewis, Nathan; Chiang, Wan-Tien; Liang, Chenguang

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ba83157b-c8c3-43b6-8fd5-c238aa8df054

Thesis Development of dynamic compartment models for industrial aerobic fed-batch fermentation processes

Nadal-Rey, Gisela; McClure, Dale D.; Kavanagh, John M. et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Development of dynamic compartment models for industrial aerobic fed-batch fermentation processes

Authors: Nadal-Rey, Gisela; McClure, Dale D.; Kavanagh, John M.; Cassells, Benny; Cornelissen, Sjef; Fletcher, David F.; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b13c2130-8a91-421a-9095-93064cac393c

Thesis Multiplex secretome engineering enhances recombinant protein production and purity

Kol, Stefan; Ley, Daniel; Wulff, Tune et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Multiplex secretome engineering enhances recombinant protein production and purity

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c440cd45-e242-4b63-9b03-861ba7d54bf2

Thesis Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions

Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions

Authors: Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup; Min Lee, Gyun

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d8293414-1d83-4cde-bd35-d5339a98b4f4

Thesis Engineering death resistance in CHO cells for improved perfusion culture

MacDonald, Michael A.; Nöbel, Matthias; Martínez, Verónica S. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Engineering death resistance in CHO cells for improved perfusion culture

Authors: MacDonald, Michael A.; Nöbel, Matthias; Martínez, Verónica S.; Baker, Kym; Shave, Evan; Gray, Peter P.; Mahler, Stephen; Munro, Trent; Nielsen, Lars K.; Marcellin, Esteban

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ce202b32-0a67-4570-a87a-ab0849f12696

Thesis Multi-omic profiling of EPO-producing CHO cell panel reveals metabolic adaptation to heterologous protein production

Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Multi-omic profiling of EPO-producing CHO cell panel reveals metabolic adaptation to heterologous protein production

Authors: Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael; Magdenoska, Olivera; Nielsen, Kristian Fog; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d87f41ff-ed91-4f7b-bc8e-f9f6e581ebcb

Thesis Identifying Drivers of Downstream Yield Variability Using Integrated Process Models: An Application to API Manufacturing

Overgaard, Tobias; Bertran, Maria Ona; Jørgensen, John Bagterp et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Identifying Drivers of Downstream Yield Variability Using Integrated Process Models: An Application to API Manufacturing

Authors: Overgaard, Tobias; Bertran, Maria Ona; Jørgensen, John Bagterp; id_orcid 0000-0001-9799-2808; Nielsen, Bo Friis; id_orcid 0000-0001-9146-9733

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c4296fd2-3123-42e0-8e21-f09af0e5990b

Thesis Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion

Ley, Daniel; Pereira, Sara; Pedersen, Lasse Ebdrup et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e6e02b2a-1da9-46ca-ab3f-71e6a95e52f8

Thesis An Online Compendium of CHO RNA-Seq Data Allows Identification of CHO Cell Line-specific Transcriptomic Signatures

Singh, Ankita; Kildegaard, Helene F.; Andersen, Mikael R. et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: An Online Compendium of CHO RNA-Seq Data Allows Identification of CHO Cell Line-specific Transcriptomic Signatures

Authors: Singh, Ankita; Kildegaard, Helene F.; Andersen, Mikael R.; id_orcid 0000-0003-4794-6808

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bf556aa7-6180-46f6-8a4f-dd827e2311ac

Thesis CHO glyco-engineering using CRISPR/Cas9 multiplexing for protein production with homogeneous N-glycan profiles

Amann, Thomas; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787 et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: CHO glyco-engineering using CRISPR/Cas9 multiplexing for protein production with homogeneous N-glycan profiles

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c6d75303-ecfd-4e56-a505-e7c61e81da81

Thesis Design of Optimal CHO Protein N-glycosylation Profiles

Amann, Thomas · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Design of Optimal CHO Protein N-glycosylation Profiles

Authors: Amann, Thomas

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f56793d2-957c-4049-bb8d-1cb2253f60a3

Thesis Predictive glycoengineering of biosimilars using a Markov chain glycosylation model

Spahn, Philipp N.; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787 et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Predictive glycoengineering of biosimilars using a Markov chain glycosylation model

Authors: Spahn, Philipp N.; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Voldborg, Bjørn Gunnar; id_orcid 0000-0002-7005-1642; Lewis, Nathan E.

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c81572eb-3d8b-4c44-b92d-952116fe851f

Thesis Bioprocess for testing engineered cho cell lines using single-use bioreactors

Decker, Marianne · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Bioprocess for testing engineered cho cell lines using single-use bioreactors

Authors: Decker, Marianne

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/dc4a0b9d-3f6c-410b-97ef-d0ede37e6c36

Thesis Targeted gene integration for improved production of therapeutic proteins in CHO cells

Sergeeva, Daria · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Targeted gene integration for improved production of therapeutic proteins in CHO cells

Authors: Sergeeva, Daria

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e5d1f7f4-51e8-4ccc-989e-2d60bf1b29d7

Thesis Customizing amino acid metabolism of Pichia pastoris for recombinant protein production

Rußmayer, Hannes; Buchetics, Markus; Mattanovich, Matthias et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Customizing amino acid metabolism of Pichia pastoris for recombinant protein production

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e65f1561-1cd7-495e-8db2-b64cc656c938

Thesis Glycoprofiling effects of media additives on IgG produced by CHO cells in fed-batch bioreactors

Kildegaard, Helene Faustrup; Fan, Yuzhou; Wagtberg Sen, Jette et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Glycoprofiling effects of media additives on IgG produced by CHO cells in fed-batch bioreactors

Authors: Kildegaard, Helene Faustrup; Fan, Yuzhou; Wagtberg Sen, Jette; Larsen, Bo; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/06580715-5855-4a31-b7d8-a2a4f0dff2c4

Thesis Modeling apoptosis resistance in CHO cells with CRISPR-mediated knockouts of Bak1, Bax, and Bok

MacDonald, Michael A.; Barry, Craig; Groves, Teddy et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Modeling apoptosis resistance in CHO cells with CRISPR-mediated knockouts of Bak1, Bax, and Bok

Authors: MacDonald, Michael A.; Barry, Craig; Groves, Teddy; Martínez, Verónica S.; Gray, Peter P.; Baker, Kym; Shave, Evan; Mahler, Stephen; Munro, Trent; Marcellin, Esteban; Nielsen, Lars K.

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f471d371-7ef9-48ac-ad01-8f0de141966f

Thesis Combinatorial treatment with lithium chloride enhances recombinant antibody production in transiently transfected CHO and HEK293E cells

Kim, Che Lin; Kwang Ha, Tae; Min Lee, Gyun · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Combinatorial treatment with lithium chloride enhances recombinant antibody production in transiently transfected CHO and HEK293E cells

Authors: Kim, Che Lin; Kwang Ha, Tae; Min Lee, Gyun

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/01b5ec11-ab2c-410e-8ab0-629bf31319da

Thesis Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells

Chevallier, Valentine; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808 et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells

Authors: Chevallier, Valentine; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Malphettes, Laetitia

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ff089eb9-bd04-4d58-a66a-ada79e4b6341

Thesis Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers

Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers

Authors: Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem; Malphettes, Laetitia; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/07c1b78f-8e1b-4264-8b5a-d74f261ebab9

Thesis Network Reconstruction and In Silico Metabolic Model of Chinese Hamster Ovary cells

Calmels, Cyrielle · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Network Reconstruction and In Silico Metabolic Model of Chinese Hamster Ovary cells

Authors: Calmels, Cyrielle

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e8e79519-7089-44aa-9964-6700b9af9251

Thesis Trends and approaches in N-Glycosylation engineering in Chinese hamster ovary cell culture

Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Trends and approaches in N-Glycosylation engineering in Chinese hamster ovary cell culture

Authors: Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/05f81555-5e37-4d88-be11-678eda3ec16b

Thesis Trends and approaches in N-Glycosylation engineering in Chinese hamster ovary cell culture

Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Trends and approaches in N-Glycosylation engineering in Chinese hamster ovary cell culture

Authors: Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1218be93-6eab-4722-851d-4378a47b79ee

Thesis Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production

Henry, Matthew N.; MacDonald, Michael A.; Orellana, Camila A. et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production

Authors: Henry, Matthew N.; MacDonald, Michael A.; Orellana, Camila A.; Gray, Peter P.; Gillard, Marianne; Baker, Kym; Nielsen, Lars K.; Marcellin, Esteban; Mahler, Stephen; Martínez, Verónica S.

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1326a05c-2af7-46f4-95fd-090bc436b967

Thesis Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

Fan, Y; Jimenez del Val, I; Muller, C et al. · 2015 · Imperial College London · DOI

Full title: Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

Authors: Fan, Y; Jimenez del Val, I; Muller, C; Sen, JW; Rasmussen, SK; Kontoravdi, C; Weilguny, D; Andersen, MR

Year: 2015

Venue: Imperial College London

DOI: http://onlinelibrary.wiley.com/doi/10.1002/bit.25450/abstract

Thesis Cascading effect in bioprocessing – the impact of mild hypothermia on CHO cell behavior and host cell protein composition

Goey, CH; Tsang, J; Bell, D et al. · 2017 · Imperial College London · DOI

Full title: Cascading effect in bioprocessing – the impact of mild hypothermia on CHO cell behavior and host cell protein composition

Authors: Goey, CH; Tsang, J; Bell, D; Kontoravdi, C

Year: 2017

Venue: Imperial College London

DOI: https://onlinelibrary.wiley.com/doi/epdf/10.1002/bit.26437

Thesis Model-based investigation of intracellular processes determining antibody Fc-glycosylation under mild hypothermia

Sou, SN; Jedrzejewski, PM; Lee, K et al. · 2016 · Imperial College London · DOI

Full title: Model-based investigation of intracellular processes determining antibody Fc-glycosylation under mild hypothermia

Authors: Sou, SN; Jedrzejewski, PM; Lee, K; Sellick, C; Polizzi, KM; Kontoravdi, C

Year: 2016

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/42617

Thesis Exploring cellular behaviour under transient gene expression and its impact on mAb productivity and Fc glycosylation

Sou, SN; Ken, L; Nayyar, K et al. · 2017 · Imperial College London · DOI

Full title: Exploring cellular behaviour under transient gene expression and its impact on mAb productivity and Fc glycosylation

Authors: Sou, SN; Ken, L; Nayyar, K; Polizzi, KM; Sellick, C; Kontoravdi, C

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/50815

Thesis Novel in vivo biosensors for monitoring of mammalian cell cultures

Goers, Lisa · 2017 · Imperial College London · DOI

Full title: Novel in vivo biosensors for monitoring of mammalian cell cultures

Authors: Goers, Lisa

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/44463

Thesis Constrained global sensitivity analysis for bioprocess design space identification

Kotidis, Pavlos; Demis, Panagiotis; Goey, Cher et al. · 2019 · Imperial College London · DOI

Full title: Constrained global sensitivity analysis for bioprocess design space identification

Authors: Kotidis, Pavlos; Demis, Panagiotis; Goey, Cher; Correa, Elisa; McIntosh, calum; Trepekli, Stefania; Shah, Nilay; Klymenko, Oleksiy; Kontoravdi, Kleio

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/66121

Thesis Computational tools for predicting and controlling the glycosylation of biopharmaceuticals

Kontoravdi, K; Jimenez Del Val, Ioscani · 2018 · Imperial College London · DOI

Full title: Computational tools for predicting and controlling the glycosylation of biopharmaceuticals

Authors: Kontoravdi, K; Jimenez Del Val, Ioscani

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/63978

Thesis Understanding the impact of bioprocess conditions on monoclonal antibody glycosylation in mammalian cell cultures through experimental and computational analyses

Sou, Si Nga · 2018 · Imperial College London · DOI

Full title: Understanding the impact of bioprocess conditions on monoclonal antibody glycosylation in mammalian cell cultures through experimental and computational analyses

Authors: Sou, Si Nga

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/58304

Thesis An integrated experimental and modelling approach for the study of apoptosis in GS-NS0 cell cultures

Usaku, Chonlatep · 2016 · Imperial College London · DOI

Full title: An integrated experimental and modelling approach for the study of apoptosis in GS-NS0 cell cultures

Authors: Usaku, Chonlatep

Year: 2016

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/31863

Thesis Mild hypothermic culture conditions impact residual host cell protein composition post-protein a chromatography

Goey, CH; Bell, David; Kontoravdi, K · 2018 · Imperial College London · DOI

Full title: Mild hypothermic culture conditions impact residual host cell protein composition post-protein a chromatography

Authors: Goey, CH; Bell, David; Kontoravdi, K

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/63191

Thesis A platform for the optimisation of metabolic pathways for glycosylation to achieve a narrow and targeted glycoform distribution

Jedrzejewski, Philip · 2017 · Imperial College London · DOI

Full title: A platform for the optimisation of metabolic pathways for glycosylation to achieve a narrow and targeted glycoform distribution

Authors: Jedrzejewski, Philip

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/53386

Thesis Towards controlling the glycoform: a model framework linking extracellular metabolites to antibody glycosylation

Jedrzejewski, PM; Jimenez del Val, I; Constantinou, A et al. · 2018 · Imperial College London · DOI

Full title: Towards controlling the glycoform: a model framework linking extracellular metabolites to antibody glycosylation

Authors: Jedrzejewski, PM; Jimenez del Val, I; Constantinou, A; Dell, A; Haslam, SM; Polizzi, KM; Kontoravdi, C

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/63403

Thesis Apoptosis: A mammalian cell bioprocessing perspective

Grilo, Antonio L; Mantalaris, A · 2019 · Imperial College London · DOI

Full title: Apoptosis: A mammalian cell bioprocessing perspective

Authors: Grilo, Antonio L; Mantalaris, A

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/67883

Thesis Glycoengineering Chinese hamster ovary cells: a short history

Donini, roberto; Haslam, stuart; Kontoravdi, Kleio · 2021 · Imperial College London · DOI

Full title: Glycoengineering Chinese hamster ovary cells: a short history

Authors: Donini, roberto; Haslam, stuart; Kontoravdi, Kleio

Year: 2021

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/87918

Thesis Strategic framework for parameterization of cell culture models

Kotidis, Pavlos; Kontoravdi, Cleo · 2019 · Imperial College London · DOI

Full title: Strategic framework for parameterization of cell culture models

Authors: Kotidis, Pavlos; Kontoravdi, Cleo

Year: 2019

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000464443100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Cascading effects in bioprocessing: the impact of cell culture environment on CHO cell behaviour and host cell protein species

Goey, Cher Hui · 2017 · Imperial College London · DOI

Full title: Cascading effects in bioprocessing: the impact of cell culture environment on CHO cell behaviour and host cell protein species

Authors: Goey, Cher Hui

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/52703

Thesis Model-based optimization of antibody galactosylation in CHO cell culture

Kotidis, Pavlos; Jedrzejewski, Philip; Sou, Si Nga et al. · 2019 · Imperial College London · DOI

Full title: Model-based optimization of antibody galactosylation in CHO cell culture

Authors: Kotidis, Pavlos; Jedrzejewski, Philip; Sou, Si Nga; Sellick, Christopher; Polizzi, Karen; Del Val, Ioscani Jimenez; Kontoravdi, Cleo

Year: 2019

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/30802295

Thesis Mathematical modelling and experimental validation for optimisation and control of mammalian cell culture systems

Quiroga Campano, Ana · 2019 · Imperial College London · DOI

Full title: Mathematical modelling and experimental validation for optimisation and control of mammalian cell culture systems

Authors: Quiroga Campano, Ana

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/68071

Thesis CHO cell cultures in shake flasks and bioreactors present different host cell protein profiles in the supernatant

Goey, CH; Bell, D; Kontoravdi, C · 2019 · Imperial College London · DOI

Full title: CHO cell cultures in shake flasks and bioreactors present different host cell protein profiles in the supernatant

Authors: Goey, CH; Bell, D; Kontoravdi, C

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/67420

Thesis Osmolality effects on CHO cell growth, cell volume and antibody productivity and glycosylation

Alhuthali, Sakhr; Kotidis, Pavlos; Kontoravdi, Kleio · 2021 · Imperial College London · DOI

Full title: Osmolality effects on CHO cell growth, cell volume and antibody productivity and glycosylation

Authors: Alhuthali, Sakhr; Kotidis, Pavlos; Kontoravdi, Kleio

Year: 2021

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/88797

Thesis Synergising stoichiometric modelling with artificial neural networks to predict antibody glycosylation patterns in Chinese hamster ovary cells

Antonakoudis, Athanasios; Strain, Benjamin; Barbosa, Rodrigo et al. · 2021 · Imperial College London · DOI

Full title: Synergising stoichiometric modelling with artificial neural networks to predict antibody glycosylation patterns in Chinese hamster ovary cells

Authors: Antonakoudis, Athanasios; Strain, Benjamin; Barbosa, Rodrigo; Jimenez del Val, Ioscani; Kontoravdi, Kleio

Year: 2021

Venue: Imperial College London

DOI: https://www.sciencedirect.com/science/article/pii/S0098135421002490?via%3Dihub

Thesis DigiGlyc: A hybrid tool for reactive scheduling in cell culture systems

Kotidis, Pavlos; Pappas, Iosif; Avraamidou, Styliana et al. · 2021 · Imperial College London · DOI

Full title: DigiGlyc: A hybrid tool for reactive scheduling in cell culture systems

Authors: Kotidis, Pavlos; Pappas, Iosif; Avraamidou, Styliana; Pistikopoulos, Efstratios N; Kontoravdi, Cleo; Papathanasiou, Maria M

Year: 2021

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000697031900010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Harnessing the potential of artificial neural networks for predicting protein glycosylation

Kotidis, P; Kontoravdi, Kleio · 2020 · Imperial College London · DOI

Full title: Harnessing the potential of artificial neural networks for predicting protein glycosylation

Authors: Kotidis, P; Kontoravdi, Kleio

Year: 2020

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/80115

Thesis Mathematical modelling for bioprocess understanding and optimisation

Alhuthali, Sakhr · 2020 · Imperial College London · DOI

Full title: Mathematical modelling for bioprocess understanding and optimisation

Authors: Alhuthali, Sakhr

Year: 2020

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/84849

Thesis Integrated multi-scale mathematical models for biologics process development

Martins de Jesus Lima Grilo, António Carlos · 2020 · Imperial College London · DOI

Full title: Integrated multi-scale mathematical models for biologics process development

Authors: Martins de Jesus Lima Grilo, António Carlos

Year: 2020

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/81634

Thesis Developing a lactate-inducible transgene expression system for use in Chinese hamster ovary cells

Motraghi, Charles · 2021 · Imperial College London · DOI

Full title: Developing a lactate-inducible transgene expression system for use in Chinese hamster ovary cells

Authors: Motraghi, Charles

Year: 2021

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/87120

Thesis Population balance modelling captures host cell protein dynamics in CHO cell cultures

Alhuthali, Sakhr; Kontoravdi, Cleo · 2022 · Imperial College London · DOI

Full title: Population balance modelling captures host cell protein dynamics in CHO cell cultures

Authors: Alhuthali, Sakhr; Kontoravdi, Cleo

Year: 2022

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/96277

Thesis Strategies to control therapeutic antibody glycosylation during bioprocessing: synthesis and separation.

Edwards, Elizabeth; Livanos, Maria; Krueger, Anja et al. · 2022 · Imperial College London · DOI

Full title: Strategies to control therapeutic antibody glycosylation during bioprocessing: synthesis and separation.

Authors: Edwards, Elizabeth; Livanos, Maria; Krueger, Anja; Dell, Anne; Haslam, Stuart M; Mark Smales, C; Bracewell, Daniel G

Year: 2022

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/35182428

Thesis Engineering challenges in therapeutic protein product and process design

Papathanasiou, Maria M; Kontoravdi, Cleo · 2021 · Imperial College London · DOI

Full title: Engineering challenges in therapeutic protein product and process design

Authors: Papathanasiou, Maria M; Kontoravdi, Cleo

Year: 2021

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000544589400011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.

Kumpel, Belinda M; Saldova, Radka; Koeleman, Carolien A M et al. · 2020 · University of Cambridge · DOI

Full title: Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.

Authors: Kumpel, Belinda M; Saldova, Radka; Koeleman, Carolien A M; Abrahams, Jodie L; Ederveen, Agnes Hipgrave; Armour, Kathryn L; Olovnikova, Natalia I; Vidarsson, Gestur; Kapur, Rick; Rudd, Pauline M; Wuhrer, Manfred

Year: 2020

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/302986

Thesis Rapid antibody glycoengineering in Chinese hamster ovary cells.

Marbiah, Masue; Kotidis, Pavlos; Donini, Roberto et al. · 2022 · Imperial College London · DOI

Full title: Rapid antibody glycoengineering in Chinese hamster ovary cells.

Authors: Marbiah, Masue; Kotidis, Pavlos; Donini, Roberto; Gómez, Itzcóatl A; Jimenez Del Val, Ioscani; Haslam, Stuart M; Polizzi, Karen M; Kontoravdi, Cleo

Year: 2022

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/35723478

Thesis Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch

Gangadharan, Nishanthi · 2023 · University of Cambridge · DOI

Full title: Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch

Authors: Gangadharan, Nishanthi

Year: 2023

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/358135

Thesis Glycosylation Flux Analysis of Immunoglobulin G in Chinese Hamster Ovary Perfusion Cell Culture

Hutter, Sandro; Wolf, Moritz; Papili Gao, Nan et al. · 2018 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Glycosylation Flux Analysis of Immunoglobulin G in Chinese Hamster Ovary Perfusion Cell Culture

Authors: Hutter, Sandro; Wolf, Moritz; Papili Gao, Nan; Lepori, Dario; Schweigler, Thea; Morbidelli, Massimo; Gunawan, Rudiyanto

Year: 2018

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/294344

Thesis Bioprocess optimization under uncertainty using ensemble modeling

Liu, Yang; Gunawan, Rudiyanto · 2017 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Bioprocess optimization under uncertainty using ensemble modeling

Authors: Liu, Yang; Gunawan, Rudiyanto

Year: 2017

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/230667

Thesis Perfusion mammalian cell culture for recombinant protein manufacturing – A critical review

Bielser, Jean-Marc; Wolf, Moritz; Souquet, Jonathan et al. · 2018 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Perfusion mammalian cell culture for recombinant protein manufacturing – A critical review

Authors: Bielser, Jean-Marc; Wolf, Moritz; Souquet, Jonathan; Broly, Hervé; Morbidelli, Massimo

Year: 2018

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/268594

Thesis Scale-down modeling of CHO fed-batch processes for monoclonal antibody production

Sieck, Jochen Bastian · 2012 · ETH Zurich Research Collection · DOI

Full title: Scale-down modeling of CHO fed-batch processes for monoclonal antibody production

Authors: Sieck, Jochen Bastian

Year: 2012

Venue: ETH Zurich Research Collection

DOI: http://hdl.handle.net/20.500.11850/153701

Thesis From strain engineering to process development: monoclonal antibody production with an unnatural amino acid in Pichia pastoris

Tir, Nora; Heistinger, Lina; Grünwald-Gruber, Clemens et al. · 2022 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: From strain engineering to process development: monoclonal antibody production with an unnatural amino acid in Pichia pastoris

Authors: Tir, Nora; Heistinger, Lina; Grünwald-Gruber, Clemens; Jakob, Leo A.; Dickgiesser, Stephan; Rasche, Nicolas; Mattanovich, Diethard

Year: 2022

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/565141

Thesis CelloSelect – A synthetic cellobiose metabolic pathway for selection of stable transgenic CHO cell lines

Teixeira, Ana P.; Stücheli, Pascal; Ausländer, Simon et al. · 2022 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: CelloSelect – A synthetic cellobiose metabolic pathway for selection of stable transgenic CHO cell lines

Authors: Teixeira, Ana P.; Stücheli, Pascal; Ausländer, Simon; Ausländer, David; Schönenberger, Pascal; Hürlemann, Samuel; Fussenegger, Martin; id_orcid0000-0001-8545-667X

Year: 2022

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/526708

Thesis Estudi d'estratègies de cultiu per a cèl·lules animals, basades en eines d'instrumentació i control

Gámez Montoya, Xavier · 2011 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Estudi d'estratègies de cultiu per a cèl·lules animals, basades en eines d'instrumentació i control

Authors: Gámez Montoya, Xavier

Year: 2011

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://www.tdx.cat/TDX-0125102-110641

Thesis High-Yield Production of Extracellular Vesicle Subpopulations with Constant Quality Using Batch-Refeed Cultures

Paganini, Carolina; Boyce, Hannah; Libort, Gabriela et al. · 2023 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: High-Yield Production of Extracellular Vesicle Subpopulations with Constant Quality Using Batch-Refeed Cultures

Authors: Paganini, Carolina; Boyce, Hannah; Libort, Gabriela; Arosio, Paolo

Year: 2023

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/590829

Patent us-9982286-b2

· 2018

Full title: us-9982286-b2

Year: 2018

Patent us-9714293-b2

· 2017

Full title: us-9714293-b2

Year: 2017

Patent us-9982226-b2

· 2018

Full title: us-9982226-b2

Year: 2018

Patent us-2017114381-a1

· 2017

Full title: us-2017114381-a1

Year: 2017

Patent us-2017191101-a1

· 2017

Full title: us-2017191101-a1

Year: 2017

Patent us-2017130191-a1

· 2017

Full title: us-2017130191-a1

Year: 2017

Patent us-2017233782-a1

· 2017

Full title: us-2017233782-a1

Year: 2017

Patent us-2017137522-a1

· 2017

Full title: us-2017137522-a1

Year: 2017

Patent us-2017247445-a1

· 2017

Full title: us-2017247445-a1

Year: 2017

Patent us-2017369837-a1

· 2017

Full title: us-2017369837-a1

Year: 2017

Patent us-2018148510-a1

· 2018

Full title: us-2018148510-a1

Year: 2018

Patent us-2018202938-a1

· 2018

Full title: us-2018202938-a1

Year: 2018

Patent us-2017283505-a1

· 2017

Full title: us-2017283505-a1

Year: 2017

Patent us-2018346550-a1

· 2018

Full title: us-2018346550-a1

Year: 2018

Patent us-2022136025-a1

· 2022

Full title: us-2022136025-a1

Year: 2022

Patent us-2022356502-a1

· 2022

Full title: us-2022356502-a1

Year: 2022

Patent us-2022195029-a1

· 2022

Full title: us-2022195029-a1

Year: 2022

Patent us-2024076709-a1

· 2024

Full title: us-2024076709-a1

Year: 2024

Patent us-2012003735-a1

· 2012

Full title: us-2012003735-a1

Year: 2012

Patent us-2012021459-a1

· 2012

Full title: us-2012021459-a1

Year: 2012

Patent us-2013022957-a1

· 2013

Full title: us-2013022957-a1

Year: 2013

Patent us-2013130316-a1

· 2013

Full title: us-2013130316-a1

Year: 2013

Patent us-2013090259-a1

· 2013

Full title: us-2013090259-a1

Year: 2013

Patent us-2012309056-a1

· 2012

Full title: us-2012309056-a1

Year: 2012

Patent us-2013189737-a1

· 2013

Full title: us-2013189737-a1

Year: 2013

Patent us-2013210075-a1

· 2013

Full title: us-2013210075-a1

Year: 2013

Patent us-2013281355-a1

· 2013

Full title: us-2013281355-a1

Year: 2013

Patent us-2014178984-a1

· 2014

Full title: us-2014178984-a1

Year: 2014

Patent us-2014134674-a1

· 2014

Full title: us-2014134674-a1

Year: 2014

Patent us-2014024078-a1

· 2014

Full title: us-2014024078-a1

Year: 2014

Patent us-2014234905-a1

· 2014

Full title: us-2014234905-a1

Year: 2014

Patent us-2014032127-a1

· 2014

Full title: us-2014032127-a1

Year: 2014

Patent us-2014206038-a1

· 2014

Full title: us-2014206038-a1

Year: 2014

Patent us-2014134675-a1

· 2014

Full title: us-2014134675-a1

Year: 2014

Patent us-2014255993-a1

· 2014

Full title: us-2014255993-a1

Year: 2014

Patent us-2015038337-a1

· 2015

Full title: us-2015038337-a1

Year: 2015

Patent us-2014271633-a1

· 2014

Full title: us-2014271633-a1

Year: 2014

Patent us-2015072415-a1

· 2015

Full title: us-2015072415-a1

Year: 2015

Patent us-2015005475-a1

· 2015

Full title: us-2015005475-a1

Year: 2015

Patent us-2015166662-a1

· 2015

Full title: us-2015166662-a1

Year: 2015

Patent us-2015299644-a1

· 2015

Full title: us-2015299644-a1

Year: 2015

Patent us-2015093784-a1

· 2015

Full title: us-2015093784-a1

Year: 2015

Patent us-2016024217-a1

· 2016

Full title: us-2016024217-a1

Year: 2016

Patent us-2015087024-a1

· 2015

Full title: us-2015087024-a1

Year: 2015

Patent us-2015125905-a1

· 2015

Full title: us-2015125905-a1

Year: 2015

Patent us-2015267237-a1

· 2015

Full title: us-2015267237-a1

Year: 2015

Patent us-2015210750-a1

· 2015

Full title: us-2015210750-a1

Year: 2015

Patent us-2016039927-a1

· 2016

Full title: us-2016039927-a1

Year: 2016

Patent us-2016298072-a1

· 2016

Full title: us-2016298072-a1

Year: 2016

Patent us-2016060591-a1

· 2016

Full title: us-2016060591-a1

Year: 2016

Patent us-2016040207-a1

· 2016

Full title: us-2016040207-a1

Year: 2016

Patent us-2016186130-a1

· 2016

Full title: us-2016186130-a1

Year: 2016

Patent us-2017002392-a1

· 2017

Full title: us-2017002392-a1

Year: 2017

Patent us-2016244506-a1

· 2016

Full title: us-2016244506-a1

Year: 2016

Patent us-2016369316-a1

· 2016

Full title: us-2016369316-a1

Year: 2016

Patent us-11427848-b2

· 2022

Full title: us-11427848-b2

Year: 2022

Patent us-12195779-b2

· 2025

Full title: us-12195779-b2

Year: 2025

Patent us-2002012991-a1

· 2002

Full title: us-2002012991-a1

Year: 2002

Patent us-2003096402-a1

· 2003

Full title: us-2003096402-a1

Year: 2003

Patent us-2003203448-a1

· 2003

Full title: us-2003203448-a1

Year: 2003

Patent us-2003190710-a1

· 2003

Full title: us-2003190710-a1

Year: 2003

Patent us-2004121445-a1

· 2004

Full title: us-2004121445-a1

Year: 2004

Patent us-2004214289-a1

· 2004

Full title: us-2004214289-a1

Year: 2004

Patent us-2006240513-a1

· 2006

Full title: us-2006240513-a1

Year: 2006

Patent us-2006275867-a1

· 2006

Full title: us-2006275867-a1

Year: 2006

Patent us-2007031932-a1

· 2007

Full title: us-2007031932-a1

Year: 2007

Patent us-2008227136-a1

· 2008

Full title: us-2008227136-a1

Year: 2008

Patent us-2007231895-a1

· 2007

Full title: us-2007231895-a1

Year: 2007

Patent us-2009176269-a1

· 2009

Full title: us-2009176269-a1

Year: 2009

Patent us-2010028942-a1

· 2010

Full title: us-2010028942-a1

Year: 2010

Patent us-2009123975-a1

· 2009

Full title: us-2009123975-a1

Year: 2009

Patent us-2009325287-a1

· 2009

Full title: us-2009325287-a1

Year: 2009

Patent us-2008182297-a1

· 2008

Full title: us-2008182297-a1

Year: 2008

Patent us-2010178672-a1

· 2010

Full title: us-2010178672-a1

Year: 2010

Patent us-2010311160-a1

· 2010

Full title: us-2010311160-a1

Year: 2010

Patent us-2010093039-a1

· 2010

Full title: us-2010093039-a1

Year: 2010

Patent us-2011111495-a1

· 2011

Full title: us-2011111495-a1

Year: 2011

Patent us-2011143432-a1

· 2011

Full title: us-2011143432-a1

Year: 2011

Patent us-2011136682-a1

· 2011

Full title: us-2011136682-a1

Year: 2011

Patent us-2011177555-a1

· 2011

Full title: us-2011177555-a1

Year: 2011

Patent us-2011091936-a1

· 2011

Full title: us-2011091936-a1

Year: 2011

Patent us-2012077213-a1

· 2012

Full title: us-2012077213-a1

Year: 2012

Patent us-2011287482-a1

· 2011

Full title: us-2011287482-a1

Year: 2011

Patent us-5118618-a

· 1992

Full title: us-5118618-a

Year: 1992

Patent us-6900056-b2

· 2005

Full title: us-6900056-b2

Year: 2005

Patent us-6924124-b1

· 2005

Full title: us-6924124-b1

Year: 2005

Patent us-7601535-b1

· 2009

Full title: us-7601535-b1

Year: 2009

Patent us-8021881-b2

· 2011

Full title: us-8021881-b2

Year: 2011

Patent us-8053236-b2

· 2011

Full title: us-8053236-b2

Year: 2011

Patent us-8008043-b2

· 2011

Full title: us-8008043-b2

Year: 2011

Patent us-8093045-b2

· 2012

Full title: us-8093045-b2

Year: 2012

Patent us-8470552-b2

· 2013

Full title: us-8470552-b2

Year: 2013

Patent us-8492144-b2

· 2013

Full title: us-8492144-b2

Year: 2013

Patent us-8663945-b2

· 2014

Full title: us-8663945-b2

Year: 2014

Patent us-8512983-b2

· 2013

Full title: us-8512983-b2

Year: 2013

Patent us-8906646-b2

· 2014

Full title: us-8906646-b2

Year: 2014

Patent us-9073988-b2

· 2015

Full title: us-9073988-b2

Year: 2015

Patent us-8962290-b2

· 2015

Full title: us-8962290-b2

Year: 2015

Patent us-9012176-b2

· 2015

Full title: us-9012176-b2

Year: 2015

Patent us-8911964-b2

· 2014

Full title: us-8911964-b2

Year: 2014

Patent us-8722406-b2

· 2014

Full title: us-8722406-b2

Year: 2014

Patent us-9090867-b2

· 2015

Full title: us-9090867-b2

Year: 2015

Patent us-8765413-b2

· 2014

Full title: us-8765413-b2

Year: 2014

Patent us-9234032-b2

· 2016

Full title: us-9234032-b2

Year: 2016

Patent us-9273292-b2

· 2016

Full title: us-9273292-b2

Year: 2016

Patent us-9133493-b2

· 2015

Full title: us-9133493-b2

Year: 2015

Patent us-9228168-b2

· 2016

Full title: us-9228168-b2

Year: 2016

Patent us-9012178-b2

· 2015

Full title: us-9012178-b2

Year: 2015

Patent us-9284371-b2

· 2016

Full title: us-9284371-b2

Year: 2016

Patent us-9388447-b2

· 2016

Full title: us-9388447-b2

Year: 2016

Patent us-9506053-b2

· 2016

Full title: us-9506053-b2

Year: 2016

Patent us-9441203-b2

· 2016

Full title: us-9441203-b2

Year: 2016

Patent us-9359629-b2

· 2016

Full title: us-9359629-b2

Year: 2016

Patent us-9534246-b2

· 2017

Full title: us-9534246-b2

Year: 2017

2. Data Extraction

0/555 extracted

Paper

ALiCE®: A versatile, high yielding and scalable eukaryotic cell-free protein synthesis (CFPS) system

Mainak das Gupta; Yannick Flaskamp; Robin Roentgen et al. · 2022

Full title: ALiCE®: A versatile, high yielding and scalable eukaryotic cell-free protein synthesis (CFPS) system

DOI: https://doi.org/10.1101/2022.11.10.515920

Paper

pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis

Adams, Richard R.; Tavares, Álvaro A.; Salzberg, Adi et al. · 1998

Full title: pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis

Authors: Adams, Richard R.; Tavares, Álvaro A.; Salzberg, Adi; Bellen, Hugo J.; Glover, David M.

DOI: https://doi.org/10.1101/gad.12.10.1483

Paper

Efficient and reproducible generation of high-expressing, stable human cell lines without need for antibiotic selection

Schiedner, Gudrun; Hertel, Sabine; Bialek, Corinna et al. · 2008

Full title: Efficient and reproducible generation of high-expressing, stable human cell lines without need for antibiotic selection

Authors: Schiedner, Gudrun; Hertel, Sabine; Bialek, Corinna; Kewes, Helmut; Waschütza, Gero; Volpers, Christoph

DOI: https://doi.org/10.1186/1472-6750-8-13

Paper

Establishment and mitotic stability of an extra-chromosomal mammalian replicon

Stehle, Isa M.; Postberg, Jan; Rupprecht, Sina et al. · 2007

Full title: Establishment and mitotic stability of an extra-chromosomal mammalian replicon

Authors: Stehle, Isa M.; Postberg, Jan; Rupprecht, Sina; Cremer, Thomas; Jackson, Dean A.; Lipps, Hans J.

DOI: https://doi.org/10.1186/1471-2121-8-33

Paper

Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0

Teylaert, Béatrice; Meurice, Edwige; Bobowski, Marie et al. · 2011

Full title: Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0

Authors: Teylaert, Béatrice; Meurice, Edwige; Bobowski, Marie; Harduin‐Lepers, Anne; Gaucher, Christine; Fontayne, Alexandre; Jorieux, Sylvie; Delannoy, Philippe

DOI: https://doi.org/10.1186/1472-6750-11-1

Paper

Fluorescent labeling in semi-solid medium for selection of mammalian cells secreting high-levels of recombinant proteins

Caron, Antoine W.; Nicolas, Claire; Gaillet, Bruno et al. · 2009

Full title: Fluorescent labeling in semi-solid medium for selection of mammalian cells secreting high-levels of recombinant proteins

Authors: Caron, Antoine W.; Nicolas, Claire; Gaillet, Bruno; Ba, Ismaïla; Pinard, Maxime; Garnier, Alain; Massie, Bernard; Gilbert, Rénald

DOI: https://doi.org/10.1186/1472-6750-9-42

Paper

Generation and characterization of a new mammalian cell line continuously expressing virus-like particles of Japanese encephalitis virus for a subunit vaccine candidate

Hua, Rong-Hong; Li, Yenan; Chen, Zhenshi et al. · 2014

Full title: Generation and characterization of a new mammalian cell line continuously expressing virus-like particles of Japanese encephalitis virus for a subunit vaccine candidate

Authors: Hua, Rong-Hong; Li, Yenan; Chen, Zhenshi; Liu, Like; Huo, Hong; Wang, Xiaolei; Guo, Liping; Shen, Nan; Wang, Jingfei; Bu, Zhigao

DOI: https://doi.org/10.1186/1472-6750-14-62

Paper

Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

Imai-Nishiya, Harue; Mori, Katsuhiro; Inoue, Miho et al. · 2007

Authors: Imai-Nishiya, Harue; Mori, Katsuhiro; Inoue, Miho; Wakitani, Masako; Iida, Shigeru; Shitara, Kenya; Satoh, Mitsuo

DOI: https://doi.org/10.1186/1472-6750-7-84

Paper

Generation of diploid Pichia pastoris strains by mating and their application for recombinant protein production

Chen, Ming‐Tang; Lin, Song; Shandil, Ishaan et al. · 2012

Full title: Generation of diploid Pichia pastoris strains by mating and their application for recombinant protein production

Authors: Chen, Ming‐Tang; Lin, Song; Shandil, Ishaan; Andrews, Dewan; Stadheim, Terrance A.; Choi, Byung‐Kwon

DOI: https://doi.org/10.1186/1475-2859-11-91

Paper

Applications of cell sorting in biotechnology

Mattanovich, Diethard; Borth, Nicole · 2006

Full title: Applications of cell sorting in biotechnology

Authors: Mattanovich, Diethard; Borth, Nicole

DOI: https://doi.org/10.1186/1475-2859-5-12

Paper

Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies

Chung, Nancy PY; Matthews, Katie; Kim, Helen J. et al. · 2014

Full title: Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies

DOI: https://doi.org/10.1186/1742-4690-11-33

Paper

Recombinant protein expression by targeting pre-selected chromosomal loci

Nehlsen, Kristina; Schucht, Roland; Gama-Norton, Leonor et al. · 2009

Full title: Recombinant protein expression by targeting pre-selected chromosomal loci

Authors: Nehlsen, Kristina; Schucht, Roland; Gama-Norton, Leonor; Krömer, W.; Baer, Alexandra; Cayli, Aziz; Häuser, H.; Wirth, Dagmar

DOI: https://doi.org/10.1186/1472-6750-9-100

Paper

Production and characterization of specific monoclonal antibodies binding the Plasmodium falciparum diagnostic biomarker, histidine-rich protein 2

Leow, Chiuan Yee; Jones, Martina L.; Cheng, Qin et al. · 2014

Full title: Production and characterization of specific monoclonal antibodies binding the Plasmodium falciparum diagnostic biomarker, histidine-rich protein 2

Authors: Leow, Chiuan Yee; Jones, Martina L.; Cheng, Qin; Mahler, Stephen M.; McCarthy, James

DOI: https://doi.org/10.1186/1475-2875-13-277

Paper

Novel cell engineering of the Unfolded Protein Response to achieve efficient therapeutic protein production cell line

Michael Song; J. Hou; L. Nielsen et al. · 2015

Full title: Novel cell engineering of the Unfolded Protein Response to achieve efficient therapeutic protein production cell line

Authors: Michael Song; J. Hou; L. Nielsen; P. Gray

DOI: https://doi.org/10.1186/1753-6561-9-s9-p14

Paper

Evaluating the expression profile and stability of different UCOE containing vector combinations in mAb-producing CHO cells

Nematpour, Fatemeh Saeid; Mahboudi, Fereidoun; Vaziri, Behrouz et al. · 2017

Full title: Evaluating the expression profile and stability of different UCOE containing vector combinations in mAb-producing CHO cells

Authors: Nematpour, Fatemeh Saeid; Mahboudi, Fereidoun; Vaziri, Behrouz; Khalaj, Vahid; Ahmadi, Samira; Ahmadi, Maryam; Ebadat, Saedeh; Davami, Fatemeh

DOI: https://doi.org/10.1186/s12896-017-0330-0

Paper

High level transient production of recombinant antibodies and antibody fusion proteins in HEK293 cells

Jäger, Volker; Büssow, Konrad; Wagner, Andreas et al. · 2013

Full title: High level transient production of recombinant antibodies and antibody fusion proteins in HEK293 cells

Authors: Jäger, Volker; Büssow, Konrad; Wagner, Andreas; Weber, Susanne; Hust, Michael; Frenzel, André; Schirrmann, Thomas

DOI: https://doi.org/10.1186/1472-6750-13-52

Paper

Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell lines

Veith, Nathalie; Ziehr, Holger; MacLeod, Roderick A.F. et al. · 2016

Full title: Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell lines

Authors: Veith, Nathalie; Ziehr, Holger; MacLeod, Roderick A.F.; Reamon-Buettner, Stella Marie

DOI: https://doi.org/10.1186/s12896-016-0238-0

Paper

Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up

Madhavan, Aravind; Arun, K. B.; Sindhu, Raveendran et al. · 2021

Full title: Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up

Authors: Madhavan, Aravind; Arun, K. B.; Sindhu, Raveendran; Krishnamoorthy, Jayaram; Reshmy, R.; Sirohi, Ranjna; Pugazhendi, Arivalagan; Awasthi, Mukesh Kumar; Szakács, George; Binod, Parameswaran

DOI: https://doi.org/10.1186/s12934-021-01617-z

Paper

Preclinical development of a novel CD47 nanobody with less toxicity and enhanced anti-cancer therapeutic potential

Ma, Linlin; Zhu, Minmin; Gai, Junwei et al. · 2020

Full title: Preclinical development of a novel CD47 nanobody with less toxicity and enhanced anti-cancer therapeutic potential

Authors: Ma, Linlin; Zhu, Minmin; Gai, Junwei; Li, Guanghui; Chang, Qing; Peng, Qiao; Cao, Long‐Long; Chen, Wanqing; Zhang, Siyuan; Wan, Yakun

DOI: https://doi.org/10.1186/s12951-020-0571-2

Paper

Screening and selection strategy for the establishment of biosimilar to trastuzumab-expressing CHO-K1 cell lines

Lao, Thailin; Bueno-Soler, Alexi; Durán‐Hernández, Arnelys et al. · 2021

Full title: Screening and selection strategy for the establishment of biosimilar to trastuzumab-expressing CHO-K1 cell lines

DOI: https://doi.org/10.1186/s13568-020-01157-6

Paper

Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease?

Laustsen, Andreas H.; Johansen, K.; Engmark, Mikael et al. · 2017

Full title: Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease?

Authors: Laustsen, Andreas H.; Johansen, K.; Engmark, Mikael; Andersen, Mikael Rørdam

DOI: https://doi.org/10.1371/journal.pntd.0005361

Paper

Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G

Miyakawa, Shin; Nomura, Yusuke; Sakamoto, Taiichi et al. · 2008

Full title: Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G

Authors: Miyakawa, Shin; Nomura, Yusuke; Sakamoto, Taiichi; Yamaguchi, Yoshiki; Kato, Koichi; Yamazaki, Satoko; Nakamura, Yoshikazu

DOI: https://doi.org/10.1261/rna.1005808

Paper

Intraclonal Protein Expression Heterogeneity in Recombinant CHO Cells

Pilbrough, Warren; Munro, Trent P.; Gray, Peter P. · 2009

Full title: Intraclonal Protein Expression Heterogeneity in Recombinant CHO Cells

Authors: Pilbrough, Warren; Munro, Trent P.; Gray, Peter P.

DOI: https://doi.org/10.1371/journal.pone.0008432

Paper

SweetBac: A New Approach for the Production of Mammalianised Glycoproteins in Insect Cells

Palmberger, Dieter; Wilson, Iain B. H.; Berger, Imre et al. · 2012

Full title: SweetBac: A New Approach for the Production of Mammalianised Glycoproteins in Insect Cells

Authors: Palmberger, Dieter; Wilson, Iain B. H.; Berger, Imre; Grabherr, Reingard; Rendić, Dubravko

DOI: https://doi.org/10.1371/journal.pone.0034226

Paper

Efficient Recombinant Production in Mammalian Cells Using a Novel IR/MAR Gene Amplification Method

Araki, Yoshio; Hamafuji, Tetsuro; Noguchi, Chiemi et al. · 2012

Full title: Efficient Recombinant Production in Mammalian Cells Using a Novel IR/MAR Gene Amplification Method

Authors: Araki, Yoshio; Hamafuji, Tetsuro; Noguchi, Chiemi; Shimizu, Noriaki

DOI: https://doi.org/10.1371/journal.pone.0041787

Paper

Systematic Single-Cell Analysis of Pichia pastoris Reveals Secretory Capacity Limits Productivity

Love, Kerry R.; Politano, Timothy J.; Panagiotou, Vasiliki et al. · 2012

Full title: Systematic Single-Cell Analysis of Pichia pastoris Reveals Secretory Capacity Limits Productivity

Authors: Love, Kerry R.; Politano, Timothy J.; Panagiotou, Vasiliki; Jiang, Bo; Stadheim, Terrance A.; Love, J. Christopher

DOI: https://doi.org/10.1371/journal.pone.0037915

Paper

Rapid Transient Production in Plants by Replicating and Non-Replicating Vectors Yields High Quality Functional Anti-HIV Antibody

Sainsbury, Frank; Sack, M.; Stadlmann, Johannes et al. · 2010

Full title: Rapid Transient Production in Plants by Replicating and Non-Replicating Vectors Yields High Quality Functional Anti-HIV Antibody

Authors: Sainsbury, Frank; Sack, M.; Stadlmann, Johannes; Quendler, Heribert; Fischer, Rainer; Lomonossoff, George P.

DOI: https://doi.org/10.1371/journal.pone.0013976

Paper

An Internal Ribosome Entry Site (IRES) Mutant Library for Tuning Expression Level of Multiple Genes in Mammalian Cells

Koh, Esther Y. C.; Ho, Steven C. L.; Mariati et al. · 2013

Full title: An Internal Ribosome Entry Site (IRES) Mutant Library for Tuning Expression Level of Multiple Genes in Mammalian Cells

Authors: Koh, Esther Y. C.; Ho, Steven C. L.; Mariati; Song, Zhiwei; Bi, Xuezhi; Bardor, Muriel; Yang, Yuansheng

DOI: https://doi.org/10.1371/journal.pone.0082100

Paper

A Multi-Omics Analysis of Recombinant Protein Production in Hek293 Cells

Dietmair, Stefanie; Hodson, Mark P.; Quek, Lake‐Ee et al. · 2012

Full title: A Multi-Omics Analysis of Recombinant Protein Production in Hek293 Cells

Authors: Dietmair, Stefanie; Hodson, Mark P.; Quek, Lake‐Ee; Timmins, Nicholas; Gray, Peter P.; Nielsen, Lars K.

DOI: https://doi.org/10.1371/journal.pone.0043394

Paper

Fusion of the Dhfr/Mtx and IR/MAR Gene Amplification Methods Produces a Rapid and Efficient Method for Stable Recombinant Protein Production

Noguchi, Chiemi; Araki, Yoshio; Miki, Daisuke et al. · 2012

Full title: Fusion of the Dhfr/Mtx and IR/MAR Gene Amplification Methods Produces a Rapid and Efficient Method for Stable Recombinant Protein Production

Authors: Noguchi, Chiemi; Araki, Yoshio; Miki, Daisuke; Shimizu, Noriaki

DOI: https://doi.org/10.1371/journal.pone.0052990

Paper

Multiparameter RNA and Codon Optimization: A Standardized Tool to Assess and Enhance Autologous Mammalian Gene Expression

Fath, Stephan; Bauer, Asli; Liss, Michael A. et al. · 2011

Full title: Multiparameter RNA and Codon Optimization: A Standardized Tool to Assess and Enhance Autologous Mammalian Gene Expression

Authors: Fath, Stephan; Bauer, Asli; Liss, Michael A.; Spriestersbach, Anne; Maertens, Barbara; Hahn, Peter F.; Ludwig, Christine; Schäfer, Frank; Graf, Marcus; Wagner, Ralf

DOI: https://doi.org/10.1371/journal.pone.0017596

Paper

Biochemical Characterization of Human Anti-Hepatitis B Monoclonal Antibody Produced in the Microalgae Phaeodactylum tricornutum

Vanier, Gaëtan; Hempel, Franziska; Chan, Philippe et al. · 2015

Full title: Biochemical Characterization of Human Anti-Hepatitis B Monoclonal Antibody Produced in the Microalgae Phaeodactylum tricornutum

Authors: Vanier, Gaëtan; Hempel, Franziska; Chan, Philippe; Rodamer, Michael; Vaudry, David; Maier, Uwe G.; Lerouge, Patrice; Bardor, Muriel

DOI: https://doi.org/10.1371/journal.pone.0139282

Paper

Generation of Biologically Active Multi-Sialylated Recombinant Human EPOFc in Plants

Castilho, Alexandra; Neumann, Laura; Gattinger, Pia et al. · 2013

Full title: Generation of Biologically Active Multi-Sialylated Recombinant Human EPOFc in Plants

Authors: Castilho, Alexandra; Neumann, Laura; Gattinger, Pia; Strasser, Richard; Vorauer‐Uhl, Karola; Sterovsky, Thomas; Altmann, Friedrich; Steinkellner, Herta

DOI: https://doi.org/10.1371/journal.pone.0054836

Paper

Comparison of Internal Ribosome Entry Site (IRES) and Furin-2A (F2A) for Monoclonal Antibody Expression Level and Quality in CHO Cells

Ho, Steven C. L.; Bardor, Muriel; Li, Bin et al. · 2013

Full title: Comparison of Internal Ribosome Entry Site (IRES) and Furin-2A (F2A) for Monoclonal Antibody Expression Level and Quality in CHO Cells

Authors: Ho, Steven C. L.; Bardor, Muriel; Li, Bin; Lee, Jia Juan; Song, Zhiwei; Tong, Yen Wah; Goh, Lin‐Tang; Yang, Yuansheng

DOI: https://doi.org/10.1371/journal.pone.0063247

Paper

Transgenic Production of an Anti HIV Antibody in the Barley Endosperm

Hensel, Göetz; Floß, Doreen M.; Arcalís, Elsa et al. · 2015

Full title: Transgenic Production of an Anti HIV Antibody in the Barley Endosperm

Authors: Hensel, Göetz; Floß, Doreen M.; Arcalís, Elsa; Sack, M.; Melnik, Stanislav; Altmann, Friedrich; Rutten, Twan; Kumlehn, Jochen; Stöger, Eva; Conrad, Udo

DOI: https://doi.org/10.1371/journal.pone.0140476

Paper

Optimization of Heavy Chain and Light Chain Signal Peptides for High Level Expression of Therapeutic Antibodies in CHO Cells

Haryadi, Ryan; Ho, Steven C. L.; Kok, Yee Jiun et al. · 2015

Full title: Optimization of Heavy Chain and Light Chain Signal Peptides for High Level Expression of Therapeutic Antibodies in CHO Cells

Authors: Haryadi, Ryan; Ho, Steven C. L.; Kok, Yee Jiun; Pu, Helen X.; Zheng, Lu; Pereira, Natasha Ann; Li, Bin; Bi, Xuezhi; Goh, Lin-Tang; Yang, Yuansheng; Song, Zhiwei

DOI: https://doi.org/10.1371/journal.pone.0116878

Paper

Analyzing Clonal Variation of Monoclonal Antibody-Producing CHO Cell Lines Using an In Silico Metabolomic Platform

Ghorbaniaghdam, Atefeh; Chen, Jingkui; Henry, Olivier et al. · 2014

Full title: Analyzing Clonal Variation of Monoclonal Antibody-Producing CHO Cell Lines Using an In Silico Metabolomic Platform

Authors: Ghorbaniaghdam, Atefeh; Chen, Jingkui; Henry, Olivier; Jolicœur, Mario

DOI: https://doi.org/10.1371/journal.pone.0090832

Paper

The Development of a Recombinant scFv Monoclonal Antibody Targeting Canine CD20 for Use in Comparative Medicine

Jain, Saurabh; Aresu, Luca; Comazzi, S. et al. · 2016

Full title: The Development of a Recombinant scFv Monoclonal Antibody Targeting Canine CD20 for Use in Comparative Medicine

DOI: https://doi.org/10.1371/journal.pone.0148366

Paper

Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells

Torres, Mauro; Zúñiga, Roberto Ariel Abeldaño; Gutiérrez-González, Matías et al. · 2018

Full title: Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells

DOI: https://doi.org/10.1371/journal.pone.0194510

Paper

Evaluating the efficiency of CHEF and CMV promoter with IRES and Furin/2A linker sequences for monoclonal antibody expression in CHO cells

Ebadat, Saeedeh; Ahmadi, Samira; Ahmadi, Maryam et al. · 2017

Full title: Evaluating the efficiency of CHEF and CMV promoter with IRES and Furin/2A linker sequences for monoclonal antibody expression in CHO cells

Authors: Ebadat, Saeedeh; Ahmadi, Samira; Ahmadi, Maryam; Nematpour, Fatemeh Saeid; Barkhordari, Farzaneh; Mahdian, Reza; Davami, Fatemeh; Mahboudi, Fereidoun

DOI: https://doi.org/10.1371/journal.pone.0185967

Paper

Comparison of secretory signal peptides for heterologous protein expression in microalgae: Expanding the secretion portfolio for Chlamydomonas reinhardtii

Molino, João Vitor Dutra; Carvalho, João Carlos Monteiro de; Mayfield, Stephen P. · 2018

Full title: Comparison of secretory signal peptides for heterologous protein expression in microalgae: Expanding the secretion portfolio for Chlamydomonas reinhardtii

Authors: Molino, João Vitor Dutra; Carvalho, João Carlos Monteiro de; Mayfield, Stephen P.

DOI: https://doi.org/10.1371/journal.pone.0192433

Paper

Metabolic engineering of CHO cells for the development of a robust protein production platform

Gupta, Sanjeev Kumar; Srivastava, S. K.; Sharma, Ankit et al. · 2017

Full title: Metabolic engineering of CHO cells for the development of a robust protein production platform

Authors: Gupta, Sanjeev Kumar; Srivastava, S. K.; Sharma, Ankit; Nalage, Vaibhav H. H.; Salvi, Darshita; Kushwaha, Hiralal; Chitnis, Nikhil B.; Shukla, Pratyoosh

DOI: https://doi.org/10.1371/journal.pone.0181455

Paper

REAL-Select: Full-Length Antibody Display and Library Screening by Surface Capture on Yeast Cells

Rhiel, Laura; Krah, Simon; Günther, Ralf et al. · 2014

Full title: REAL-Select: Full-Length Antibody Display and Library Screening by Surface Capture on Yeast Cells

Authors: Rhiel, Laura; Krah, Simon; Günther, Ralf; Becker, Stefan; Kolmar, Harald; Hock, Björn

DOI: https://doi.org/10.1371/journal.pone.0114887

Paper

Monoclonal antibodies expression improvement in CHO cells by PiggyBac transposition regarding vectors ratios and design

Ahmadi, Samira; Davami, Fatemeh; Davoudi, Noushin et al. · 2017

Full title: Monoclonal antibodies expression improvement in CHO cells by PiggyBac transposition regarding vectors ratios and design

Authors: Ahmadi, Samira; Davami, Fatemeh; Davoudi, Noushin; Nematpour, Fatemeh Saeid; Ahmadi, Maryam; Ebadat, Saeedeh; Azadmanesh, Kayhan; Barkhordari, Farzaneh; Mahboudi, Fereidoun

DOI: https://doi.org/10.1371/journal.pone.0179902

Paper

Chromatin Function Modifying Elements in an Industrial Antibody Production Platform - Comparison of UCOE, MAR, STAR and cHS4 Elements

Saunders, Fay Louise; Sweeney, Berni; Antoniou, Michael et al. · 2015

Full title: Chromatin Function Modifying Elements in an Industrial Antibody Production Platform - Comparison of UCOE, MAR, STAR and cHS4 Elements

Authors: Saunders, Fay Louise; Sweeney, Berni; Antoniou, Michael; Stephens, Paul E.; Cain, Katharine

DOI: https://doi.org/10.1371/journal.pone.0120096

Paper

Monoclonal antibodies for the prevention of rabies: theory and clinical practice

Nagarajan, Thirumeni; Marissen, Wilfred E.; Rupprecht, Charles E. · 2014

Full title: Monoclonal antibodies for the prevention of rabies: theory and clinical practice

Authors: Nagarajan, Thirumeni; Marissen, Wilfred E.; Rupprecht, Charles E.

DOI: https://doi.org/10.2147/anti.s33533

Paper

A system for site-specific integration of transgenes in mammalian cells

Chi, Xiuling; Zheng, Qi; Jiang, Ruhong et al. · 2019

Full title: A system for site-specific integration of transgenes in mammalian cells

Authors: Chi, Xiuling; Zheng, Qi; Jiang, Ruhong; Chen-Tsai, Ruby Yanru; Kong, Ling-Jie

DOI: https://doi.org/10.1371/journal.pone.0219842

Paper

Advances in improving mammalian cells metabolism for recombinant protein production

Altamirano, Claudia; Berríos, Julio; Vergara, Mauricio et al. · 2013

Full title: Advances in improving mammalian cells metabolism for recombinant protein production

Authors: Altamirano, Claudia; Berríos, Julio; Vergara, Mauricio; Becerra, Silvana

DOI: https://doi.org/10.2225/vol16-issue3-fulltext-2

Paper

Factors Affecting the Expression of Recombinant Protein and Improvement Strategies in Chinese Hamster Ovary Cells

Li, Zhengmei; Fan, Zhenlin; Wang, Xiao-Yin et al. · 2022

Full title: Factors Affecting the Expression of Recombinant Protein and Improvement Strategies in Chinese Hamster Ovary Cells

Authors: Li, Zhengmei; Fan, Zhenlin; Wang, Xiao-Yin; Wang, Tianyun

DOI: https://doi.org/10.3389/fbioe.2022.880155

Paper

Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry

Sumit Kumar Singh; Kelvin H. Lee · 2022

Full title: Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry

Authors: Sumit Kumar Singh; Kelvin H. Lee

DOI: https://doi.org/10.3389/fbioe.2021.805788

Paper

Screening Strategies for High-Yield Chinese Hamster Ovary Cell Clones

Yang, Wenwen; Zhang, Junhe; Xiao, Yunxi et al. · 2022

Full title: Screening Strategies for High-Yield Chinese Hamster Ovary Cell Clones

Authors: Yang, Wenwen; Zhang, Junhe; Xiao, Yunxi; Li, Wenqing; Wang, Tianyun

DOI: https://doi.org/10.3389/fbioe.2022.858478

Paper

Crystallizable Fragment Glycoengineering for Therapeutic Antibodies Development

Li, Wei; Zhu, Zhongyu; Chen, Weizao et al. · 2017

Full title: Crystallizable Fragment Glycoengineering for Therapeutic Antibodies Development

Authors: Li, Wei; Zhu, Zhongyu; Chen, Weizao; Feng, Yang; Dimitrov, Dimiter S.

DOI: https://doi.org/10.3389/fimmu.2017.01554

Paper

Engineering protein glycosylation in CHO cells to be highly similar to murine host cells

Gupta, Shivani; Shah, Bhavana; Fung, Coral Shek et al. · 2023

Full title: Engineering protein glycosylation in CHO cells to be highly similar to murine host cells

Authors: Gupta, Shivani; Shah, Bhavana; Fung, Coral Shek; Chan, Pik K.; Wakefield, Devin L.; Kuhns, Scott; Goudar, Chetan T.; Piret, James M.

DOI: https://doi.org/10.3389/fbioe.2023.1113994

Paper

Strategies and Considerations for Improving Recombinant Antibody Production and Quality in Chinese Hamster Ovary Cells

Zhang, Junhe; Shan, Linlin; Liang, Fan et al. · 2022

Full title: Strategies and Considerations for Improving Recombinant Antibody Production and Quality in Chinese Hamster Ovary Cells

Authors: Zhang, Junhe; Shan, Linlin; Liang, Fan; Du, Chenyang; Li, Jinɡjinɡ

DOI: https://doi.org/10.3389/fbioe.2022.856049

Paper

Role of Fc Core Fucosylation in the Effector Function of IgG1 Antibodies

Golay, Josée; Andrea, Alain E.; Cattaneo, Irene · 2022

Full title: Role of Fc Core Fucosylation in the Effector Function of IgG1 Antibodies

Authors: Golay, Josée; Andrea, Alain E.; Cattaneo, Irene

DOI: https://doi.org/10.3389/fimmu.2022.929895

Paper

Risk-Based Control Strategies of Recombinant Monoclonal Antibody Charge Variants

Beck, Alain; Nowak, Christine; Meshulam, Deborah et al. · 2022

Full title: Risk-Based Control Strategies of Recombinant Monoclonal Antibody Charge Variants

DOI: https://doi.org/10.3390/antib11040073

Paper

Protein N-glycosylation in eukaryotic microalgae and its impact on the production of nuclear expressed biopharmaceuticals

Mathieu‐Rivet, Elodie; Kiefer‐Meyer, Marie‐Christine; Vanier, Gaëtan et al. · 2014

Full title: Protein N-glycosylation in eukaryotic microalgae and its impact on the production of nuclear expressed biopharmaceuticals

Authors: Mathieu‐Rivet, Elodie; Kiefer‐Meyer, Marie‐Christine; Vanier, Gaëtan; Ovide, ClÃ©ment; Burel, Carole; Lerouge, Patrice; Bardor, Muriel

DOI: https://doi.org/10.3389/fpls.2014.00359

Paper

Sophisticated Cloning, Fermentation, and Purification Technologies for an Enhanced Therapeutic Protein Production: A Review

Gupta, Sanjeev Kumar; Shukla, Pratyoosh · 2017

Full title: Sophisticated Cloning, Fermentation, and Purification Technologies for an Enhanced Therapeutic Protein Production: A Review

Authors: Gupta, Sanjeev Kumar; Shukla, Pratyoosh

DOI: https://doi.org/10.3389/fphar.2017.00419

Paper

Development of a Novel Anti-EpCAM Monoclonal Antibody for Various Applications

Guanjie Li; Hiroyuki Suzuki; Teizo Asano et al. · 2022

Full title: Development of a Novel Anti-EpCAM Monoclonal Antibody for Various Applications

Authors: Guanjie Li; Hiroyuki Suzuki; Teizo Asano; Tomohiro Tanaka; Hiroyoshi Suzuki; M. Kaneko; Y. Kato

DOI: https://doi.org/10.3390/antib11020041

Paper

Putting the Spotlight Back on Plant Suspension Cultures

Santos, Rita B.; Abranches, Rita; Fischer, Rainer et al. · 2016

Full title: Putting the Spotlight Back on Plant Suspension Cultures

Authors: Santos, Rita B.; Abranches, Rita; Fischer, Rainer; Sack, M.; Holland, Tanja

DOI: https://doi.org/10.3389/fpls.2016.00297

Paper

NanoLuc Luciferase – A Multifunctional Tool for High Throughput Antibody Screening

Boute, Nicolas; Lowe, Peter; Berger, Sven et al. · 2016

Full title: NanoLuc Luciferase – A Multifunctional Tool for High Throughput Antibody Screening

Authors: Boute, Nicolas; Lowe, Peter; Berger, Sven; Malissard, Martine; Robert, Alain; Tesar, Michael

DOI: https://doi.org/10.3389/fphar.2016.00027

Paper

Improved Titer in Late-Stage Mammalian Cell Culture Manufacturing by Re-Cloning.

He, Qin; Rehmann, Matthew S; Tian, Jun et al. · 2022

Full title: Improved Titer in Late-Stage Mammalian Cell Culture Manufacturing by Re-Cloning.

DOI: https://doi.org/10.3390/bioengineering9040173

Paper

Current Advancements in Addressing Key Challenges of Therapeutic Antibody Design, Manufacture, and Formulation

Sifniotis, Vicki; Cruz, Esteban; Eroglu, Barbaros et al. · 2019

Full title: Current Advancements in Addressing Key Challenges of Therapeutic Antibody Design, Manufacture, and Formulation

Authors: Sifniotis, Vicki; Cruz, Esteban; Eroglu, Barbaros; Kayser, Veysel

DOI: https://doi.org/10.3390/antib8020036

Paper

Affecting HEK293 Cell Growth and Production Performance by Modifying the Expression of Specific Genes

Abaandou, Laura; Quan, David N.; Shiloach, Joseph · 2021

Full title: Affecting HEK293 Cell Growth and Production Performance by Modifying the Expression of Specific Genes

Authors: Abaandou, Laura; Quan, David N.; Shiloach, Joseph

DOI: https://doi.org/10.3390/cells10071667

Paper

Industrial Production of Proteins with Pichia pastoris—Komagataella phaffii

Barone, Giovanni Davide; Emmerstorfer‐Augustin, Anita; Biundo, Antonino et al. · 2023

Full title: Industrial Production of Proteins with Pichia pastoris—Komagataella phaffii

Authors: Barone, Giovanni Davide; Emmerstorfer‐Augustin, Anita; Biundo, Antonino; Pisano, Isabella; Coccetti, Paola; Mapelli, Valeria; Camattari, Andrea

DOI: https://doi.org/10.3390/biom13030441

Paper

Function and 3D Structure of the N-Glycans on Glycoproteins

Nagae, Masamichi; Yamaguchi, Yoshiki · 2012

Full title: Function and 3D Structure of the N-Glycans on Glycoproteins

Authors: Nagae, Masamichi; Yamaguchi, Yoshiki

DOI: https://doi.org/10.3390/ijms13078398

Paper

Trends in Upstream and Downstream Process Development for Antibody Manufacturing

Gronemeyer, Petra; Ditz, Reinhard; Strube, Jochen · 2014

Full title: Trends in Upstream and Downstream Process Development for Antibody Manufacturing

Authors: Gronemeyer, Petra; Ditz, Reinhard; Strube, Jochen

DOI: https://doi.org/10.3390/bioengineering1040188

Paper

A Bench-Top Approach for Isolation of Single Antibody Producing Chinese Hamster Ovary (CHO) Cells Using a Microwell-Based Microfluidic Device.

Fuadiyah, Salma; Chotchindakun, Kittipat; Phatthanakun, Rungrueang et al. · 2022

Full title: A Bench-Top Approach for Isolation of Single Antibody Producing Chinese Hamster Ovary (CHO) Cells Using a Microwell-Based Microfluidic Device.

Authors: Fuadiyah, Salma; Chotchindakun, Kittipat; Phatthanakun, Rungrueang; Kuntanawat, Panwong; Yamabhai, Montarop

DOI: https://doi.org/10.3390/mi13111939

Paper

A Simple Method to Reduce both Lactic Acid and Ammonium Production in Industrial Animal Cell Culture

Freund, N; Croughan, Matthew S. · 2018

Full title: A Simple Method to Reduce both Lactic Acid and Ammonium Production in Industrial Animal Cell Culture

Authors: Freund, N; Croughan, Matthew S.

DOI: https://doi.org/10.3390/ijms19020385

Paper

Advances in Mammalian Cell Line Development Technologies for Recombinant Protein Production

Lai, Tingfeng; Yang, Yuansheng; Ng, Say Kong · 2013

Full title: Advances in Mammalian Cell Line Development Technologies for Recombinant Protein Production

Authors: Lai, Tingfeng; Yang, Yuansheng; Ng, Say Kong

DOI: https://doi.org/10.3390/ph6050579

Paper

CRISPR Technologies in Chinese Hamster Ovary Cell Line Engineering

Glinšek, Katja; Bozovičar, Krištof; Bratkovič, Tomaž · 2023

Full title: CRISPR Technologies in Chinese Hamster Ovary Cell Line Engineering

Authors: Glinšek, Katja; Bozovičar, Krištof; Bratkovič, Tomaž

DOI: https://doi.org/10.3390/ijms24098144

Paper

Photopolymer Flexographic Printing Plate Mold for PDMS Microfluidic Manufacture

Ana Belén Peñaherrera‐Pazmiño; Gustavo Rosero; Maximiliano S. Perez et al. · 2025

Full title: Photopolymer Flexographic Printing Plate Mold for PDMS Microfluidic Manufacture

Authors: Ana Belén Peñaherrera‐Pazmiño; Gustavo Rosero; Maximiliano S. Perez; B. Lerner

DOI: https://doi.org/10.3390/polym17131723

Paper

Identification of Cystatin SN as a novel tumor marker for colorectal cancer.

K. Yoneda; Hiroshi Iida; Hiroki Endo et al. · 2009

Full title: Identification of Cystatin SN as a novel tumor marker for colorectal cancer.

DOI: https://doi.org/10.3892/ijo_00000310

Paper

Monoclonal antibodies to human interferon‐gamma: production, affinity purification and radioimmunoassay.

D. Novick; Zelig Eshhar; D. Fischer et al. · 1983

Full title: Monoclonal antibodies to human interferon‐gamma: production, affinity purification and radioimmunoassay.

Authors: D. Novick; Zelig Eshhar; D. Fischer; J. Friedlander; Menachem Rubinstein

DOI: https://doi.org/10.1002/j.1460-2075.1983.tb01618.x

Paper

Amino acids in the cultivation of mammalian cells

Salazar, Andrew; Keusgen, Michael; Hagen, Jörg von · 2016

Full title: Amino acids in the cultivation of mammalian cells

Authors: Salazar, Andrew; Keusgen, Michael; Hagen, Jörg von

DOI: https://doi.org/10.1007/s00726-016-2181-8

Paper

Effects of process intensification on homogeneity of an IgG1:κ monoclonal antibody during perfusion culture

Liang, George H.; Madhavarao, Chikkathur N.; Morris, Caitlin et al. · 2024

Full title: Effects of process intensification on homogeneity of an IgG1:κ monoclonal antibody during perfusion culture

Authors: Liang, George H.; Madhavarao, Chikkathur N.; Morris, Caitlin; O'Connor, T; Ashraf, Muhammad; Yoon, Seongkyu

DOI: https://doi.org/10.1007/s00253-024-13110-9

Paper

Transposon vector-mediated stable gene transfer for the accelerated establishment of recombinant mammalian cell pools allowing for high-yield production of biologics

Natalie Tschorn; K. Berg; J. Stitz · 2020

Full title: Transposon vector-mediated stable gene transfer for the accelerated establishment of recombinant mammalian cell pools allowing for high-yield production of biologics

Authors: Natalie Tschorn; K. Berg; J. Stitz

DOI: https://doi.org/10.1007/s10529-020-02889-y

Paper

The role of Raman spectroscopy in biopharmaceuticals from development to manufacturing

Esmonde‐White, Karen A.; Cuellar, Maryann; Lewis, Ian R. · 2021

Full title: The role of Raman spectroscopy in biopharmaceuticals from development to manufacturing

Authors: Esmonde‐White, Karen A.; Cuellar, Maryann; Lewis, Ian R.

DOI: https://doi.org/10.1007/s00216-021-03727-4

Paper

Recombinant therapeutic proteins degradation and overcoming strategies in CHO cells

Geng, Shao‐Lei; Zhao, Xiaojie; Zhang, Xi et al. · 2024

Full title: Recombinant therapeutic proteins degradation and overcoming strategies in CHO cells

Authors: Geng, Shao‐Lei; Zhao, Xiaojie; Zhang, Xi; Zhang, Jihong; Mi, Chunliu; Wang, Tianyun

DOI: https://doi.org/10.1007/s00253-024-13008-6

Paper

Albumin and mammalian cell culture: implications for biotechnology applications

Francis, Geoffrey L. · 2010

Full title: Albumin and mammalian cell culture: implications for biotechnology applications

Authors: Francis, Geoffrey L.

DOI: https://doi.org/10.1007/s10616-010-9263-3

Paper

Developing the Totality of Evidence for Biosimilars: Regulatory Considerations and Building Confidence for the Healthcare Community

Márkus, Richárd; Liu, Jennifer; Ramchandani, Monica et al. · 2017

Full title: Developing the Totality of Evidence for Biosimilars: Regulatory Considerations and Building Confidence for the Healthcare Community

Authors: Márkus, Richárd; Liu, Jennifer; Ramchandani, Monica; Landa, Diana; Born, Teresa L.; Kaur, Primal

DOI: https://doi.org/10.1007/s40259-017-0218-5

Paper

Single-Batch Production of Recombinant Human Polyclonal Antibodies

Nielsen, Lars S.; Baer, Alexandra; Müller, Christian et al. · 2010

Full title: Single-Batch Production of Recombinant Human Polyclonal Antibodies

Authors: Nielsen, Lars S.; Baer, Alexandra; Müller, Christian; Gregersen, Kristian; Mønster, Nina T.; Rasmussen, Søren K.; Weilguny, Dietmar; Tolstrup, Anne B.

DOI: https://doi.org/10.1007/s12033-010-9270-9

Paper

Physicochemical and Functional Comparability Between the Proposed Biosimilar Rituximab GP2013 and Originator Rituximab

Visser, Jan Marinus; Feuerstein, Isabel; Stangler, Thomas et al. · 2013

Full title: Physicochemical and Functional Comparability Between the Proposed Biosimilar Rituximab GP2013 and Originator Rituximab

Authors: Visser, Jan Marinus; Feuerstein, Isabel; Stangler, Thomas; Schmiederer, Timo; Fritsch, Cornelius; Schiestl, Martin

DOI: https://doi.org/10.1007/s40259-013-0036-3

Paper

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

Xu, Xun; Nagarajan, Harish; Lewis, Nathan E. et al. · 2011

Full title: The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

DOI: https://doi.org/10.1038/nbt.1932

Paper

A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency

Chodorge, Matthieu; Züger, Sara; Stirnimann, Christian U. et al. · 2012

Full title: A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency

Authors: Chodorge, Matthieu; Züger, Sara; Stirnimann, Christian U.; Briand, Christophe; Jermutus, Lutz; Grütter, Markus G.; Minter, Ralph

DOI: https://doi.org/10.1038/cdd.2011.208

Paper

MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP

Yan, Yahui; Rato, Cláudia; Rohland, Lukas et al. · 2019

Full title: MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP

Authors: Yan, Yahui; Rato, Cláudia; Rohland, Lukas; Preißler, Steffen; Ron, David

DOI: https://doi.org/10.1038/s41467-019-08450-4

Paper

The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells

Tian, Weihua; Ye, Zilu; Wang, Shengjun et al. · 2019

Full title: The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells

DOI: https://doi.org/10.1038/s41467-019-09809-3

Paper

S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

Liang, Joshua G.; Su, Danmei; Song, Tian‐Zhang et al. · 2021

Full title: S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

DOI: https://doi.org/10.1038/s41467-021-21634-1

Paper

Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG

Fischer, Nicolas; Elson, Greg; Magistrelli, Giovanni et al. · 2015

Full title: Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG

DOI: https://doi.org/10.1038/ncomms7113

Paper

Multiplex secretome engineering enhances recombinant protein production and purity

Kol, Stefan; Ley, Daniel; Wulff, Tune et al. · 2020

Full title: Multiplex secretome engineering enhances recombinant protein production and purity

DOI: https://doi.org/10.1038/s41467-020-15866-w

Paper

Developing therapeutic monoclonal antibodies at pandemic pace

Kelley, Brian D. · 2020

Full title: Developing therapeutic monoclonal antibodies at pandemic pace

Authors: Kelley, Brian D.

DOI: https://doi.org/10.1038/s41587-020-0512-5

Paper

Single-cell sorting based on secreted products for functionally defined cell therapies

Miwa, Hiromi; Dimatteo, Robert; Rutte, Joseph de et al. · 2022

Full title: Single-cell sorting based on secreted products for functionally defined cell therapies

Authors: Miwa, Hiromi; Dimatteo, Robert; Rutte, Joseph de; Ghosh, Rajesh; Carlo, Dino Di

DOI: https://doi.org/10.1038/s41378-022-00422-x

Paper

Protein design and variant prediction using autoregressive generative models

Shin, Jung-Eun; Riesselman, Adam J.; Kollasch, Aaron W. et al. · 2021

Full title: Protein design and variant prediction using autoregressive generative models

Authors: Shin, Jung-Eun; Riesselman, Adam J.; Kollasch, Aaron W.; McMahon, Conor; Simon, Elana P.; Sander, Chris; Manglik, Aashish; Kruse, Andrew C.; Marks, Debora S.

DOI: https://doi.org/10.1038/s41467-021-22732-w

Paper

A human expression system based on HEK293 for the stable production of recombinant erythropoietin

Chin, Christine Lin; Goh, Justin B.; Srinivasan, Harini et al. · 2019

Full title: A human expression system based on HEK293 for the stable production of recombinant erythropoietin

DOI: https://doi.org/10.1038/s41598-019-53391-z

Paper

High-yield production of “difficult-to-express” proteins in a continuous exchange cell-free system based on CHO cell lysates

Thoring, Lena; Dondapati, Srujan Kumar; Stech, Marlitt et al. · 2017

Full title: High-yield production of “difficult-to-express” proteins in a continuous exchange cell-free system based on CHO cell lysates

Authors: Thoring, Lena; Dondapati, Srujan Kumar; Stech, Marlitt; Wüstenhagen, Doreen A.; Kubick, Stefan

DOI: https://doi.org/10.1038/s41598-017-12188-8

Paper

Next generation of anti-PD-L1 Atezolizumab with enhanced anti-tumor efficacy in vivo

Li, Maohua; Zhao, Rongqing; Chen, Jianxin et al. · 2021

Full title: Next generation of anti-PD-L1 Atezolizumab with enhanced anti-tumor efficacy in vivo

Authors: Li, Maohua; Zhao, Rongqing; Chen, Jianxin; Tian, Wenzhi; Xia, Chenxi; Liu, Xudong; Li, Yingzi; Li, Song; Sun, Hunter; Shen, Tong; Ren, Wenlin; Sun, Le

DOI: https://doi.org/10.1038/s41598-021-85329-9

Paper

Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

Noh, Soo Min; Shin, Seunghyeon; Lee, Gyun Min · 2018

Full title: Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

Authors: Noh, Soo Min; Shin, Seunghyeon; Lee, Gyun Min

DOI: https://doi.org/10.1038/s41598-018-23720-9

Paper

Selection and characterization of DNA aptamer against glucagon receptor by cell-SELEX

Wang, Guodong; Liu, Jun; Chen, Ke et al. · 2017

Full title: Selection and characterization of DNA aptamer against glucagon receptor by cell-SELEX

Authors: Wang, Guodong; Liu, Jun; Chen, Ke; Xu, Yiling; Liu, Bo; Liao, Jie; Zhu, Lei; Hu, Xiaoxiao; Li, Jianglin; Pu, Ying; Zhong, Wen; Fu, Ting; Liu, Huixia; Tan, Weihong

DOI: https://doi.org/10.1038/s41598-017-05840-w

Paper

Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system

S. Murakami; R. Matsumoto; T. Kanamori · 2019

Full title: Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system

Authors: S. Murakami; R. Matsumoto; T. Kanamori

DOI: https://doi.org/10.1038/s41598-018-36691-8

Paper

Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

H. Hansen; Claes Nymand Nilsson; A. Lund et al. · 2015

Full title: Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Authors: H. Hansen; Claes Nymand Nilsson; A. Lund; S. Kol; L. M. Grav; Magnus Lundqvist; Johan Rockberg; G. Lee; M. Andersen; H. F. Kildegaard

DOI: https://doi.org/10.1038/srep18016

Paper

Identification of a monoclonal antibody that targets PD-1 in a manner requiring PD-1 Asn58 glycosylation

Wang, Mingzhu; Wang, Junchao; Wang, Rongjuan et al. · 2019

Full title: Identification of a monoclonal antibody that targets PD-1 in a manner requiring PD-1 Asn58 glycosylation

Authors: Wang, Mingzhu; Wang, Junchao; Wang, Rongjuan; Jiao, Shasha; Wang, Shuang; Zhang, Jinchao; Zhang, Min

DOI: https://doi.org/10.1038/s42003-019-0642-9

Paper

Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR

Panousis, Con; Rayzman, Veronika; Johns, Terrance G. et al. · 2005

Full title: Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR

DOI: https://doi.org/10.1038/sj.bjc.6602470

Paper

The ENGases: versatile biocatalysts for the production of homogeneous N-linked glycopeptides and glycoproteins

Fairbanks, Antony J. · 2017

Full title: The ENGases: versatile biocatalysts for the production of homogeneous N-linked glycopeptides and glycoproteins

Authors: Fairbanks, Antony J.

DOI: https://doi.org/10.1039/c6cs00897f

Paper

CMV promoter mutants with a reduced propensity to productivity loss in CHO cells

Moritz, Benjamin; Becker, Peter B.; Göpfert, Ulrich · 2015

Full title: CMV promoter mutants with a reduced propensity to productivity loss in CHO cells

Authors: Moritz, Benjamin; Becker, Peter B.; Göpfert, Ulrich

DOI: https://doi.org/10.1038/srep16952

Paper

Impact of Different Promoters on Episomal Vectors Harbouring Characteristic Motifs of Matrix Attachment Regions

Wang, Xiao-Yin; Zhang, Jun‐He; Zhang, Xi et al. · 2016

Full title: Impact of Different Promoters on Episomal Vectors Harbouring Characteristic Motifs of Matrix Attachment Regions

Authors: Wang, Xiao-Yin; Zhang, Jun‐He; Zhang, Xi; Sun, Qiu‐li; Zhao, Chun-Peng; Wang, Tianyun

DOI: https://doi.org/10.1038/srep26446

Paper

Matrix attachment region combinations increase transgene expression in transfected Chinese hamster ovary cells

Zhao, Chun‐Peng; Guo, Xiao; Chen, Si‐Jia et al. · 2017

Full title: Matrix attachment region combinations increase transgene expression in transfected Chinese hamster ovary cells

Authors: Zhao, Chun‐Peng; Guo, Xiao; Chen, Si‐Jia; Li, Changzheng; Yang, Yun; Zhang, Junhe; Chen, Shao-nan; Jia, Yan‐Long; Wang, Tianyun

DOI: https://doi.org/10.1038/srep42805

Paper

Analytical Characterization of Monoclonal Antibodies with Novel Fc Receptor-Based Chromatography Technique

A. Chakrabarti; J. Kervinen; E. Müller et al. · 2020

Full title: Analytical Characterization of Monoclonal Antibodies with Novel Fc Receptor-Based Chromatography Technique

Authors: A. Chakrabarti; J. Kervinen; E. Müller; Toru Tanaka; Kazuaki Muranaka

DOI: https://doi.org/10.5772/intechopen.95356

Paper

The impact of cell culture on medicine

Ying Chun Lu; Taohsueh Liao · 2024

Full title: The impact of cell culture on medicine

Authors: Ying Chun Lu; Taohsueh Liao

DOI: https://doi.org/10.54615/2231-7805.20169

Paper

Strategies for Glycoengineering Therapeutic Proteins

Dammen‐Brower, Kris; Epler, Paige; Zhu, Stanley et al. · 2022

Full title: Strategies for Glycoengineering Therapeutic Proteins

Authors: Dammen‐Brower, Kris; Epler, Paige; Zhu, Stanley; Bernstein, Zachary J.; Stabach, Paul R.; Braddock, Demetrios T.; Spangler, Jamie B.; Yarema, Kevin J.

DOI: https://doi.org/10.3389/fchem.2022.863118

Paper

Recent Developments in Bioprocessing of Recombinant Proteins: Expression Hosts and Process Development

Tripathi, Nagesh K.; Shrivastava, Ambuj · 2019

Full title: Recent Developments in Bioprocessing of Recombinant Proteins: Expression Hosts and Process Development

Authors: Tripathi, Nagesh K.; Shrivastava, Ambuj

DOI: https://doi.org/10.3389/fbioe.2019.00420

Paper

Expression of Recombinant Antibodies

Frenzel, André; Hust, Michael; Schirrmann, Thomas · 2013

Full title: Expression of Recombinant Antibodies

Authors: Frenzel, André; Hust, Michael; Schirrmann, Thomas

DOI: https://doi.org/10.3389/fimmu.2013.00217

Paper

Improving Immunotherapy Through Glycodesign

Buettner, Matthew J.; Shah, Sagar; Saeui, Christopher T. et al. · 2018

Full title: Improving Immunotherapy Through Glycodesign

Authors: Buettner, Matthew J.; Shah, Sagar; Saeui, Christopher T.; Ariss, Ryan; Yarema, Kevin J.

DOI: https://doi.org/10.3389/fimmu.2018.02485

Thesis

Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing

Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP] et al. · 2019

Full title: Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing

Authors: Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP]; Deffune, Elenice; Suazo, Cláudio Alberto Torres

DOI: http://dx.doi.org/10.1590/0104-6632.20180352s20160463

Thesis

Model comparison to describe BHK-21 cell growth and metabolism in stirred tank bioreactors operated in batch mode

Fernández Núñez, Eutimio Gustavo · 2018

Full title: Model comparison to describe BHK-21 cell growth and metabolism in stirred tank bioreactors operated in batch mode

Authors: Fernández Núñez, Eutimio Gustavo

DOI: https://doi.org/10.1590/0104-6632.20180352s20160592

Thesis

NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods

De Leoz, Maria Lorna A; Duewer, David L; Fung, Adam et al. · 2020

Full title: NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods

DOI: https://dspace.library.uu.nl/handle/1874/394141

Thesis

Automated pipeline for rapid production and screening of HIV-specific monoclonal antibodies using pichia pastoris

Shah, Kartik A; Clark, John J; Goods, Brittany A. et al. · 2017

Full title: Automated pipeline for rapid production and screening of HIV-specific monoclonal antibodies using pichia pastoris

Authors: Shah, Kartik A; Clark, John J; Goods, Brittany A.; Politano, Timothy James; Mozdzierz, Nicholas Joseph; Zimnisky, Ross; Leeson, Rachel; Love, John C; Love, Kerry R.

DOI: http://hdl.handle.net/1721.1/109438

Thesis

Effect of adenosine and cordycepin on recombinant antibody production yields in two different Chinease hamster ovary cell lines

Jarusintanakorn, Salinthip; Rangnoi, Kuntalee; Yamabhai, Montarop et al. · 2024

Full title: Effect of adenosine and cordycepin on recombinant antibody production yields in two different Chinease hamster ovary cell lines

Authors: Jarusintanakorn, Salinthip; Rangnoi, Kuntalee; Yamabhai, Montarop; Mastrobattista, Enrico

DOI: https://dspace.library.uu.nl/handle/1874/438035

Thesis

Microfluidic Cell Retention Device for Perfusion of Mammalian Suspension Culture

Prentice, Holly; Warkiani, Majid Ebrahimi; Kwon, Taehong et al. · 2017

Full title: Microfluidic Cell Retention Device for Perfusion of Mammalian Suspension Culture

Authors: Prentice, Holly; Warkiani, Majid Ebrahimi; Kwon, Taehong; De Oliveira, Jonas; Madziva, Nyasha; Hamel, Jean-Francois P; Han, Jongyoon

DOI: http://hdl.handle.net/1721.1/112686

Thesis

Small-molecule control of antibody N-glycosylation in engineered mammalian cells

Chang, Michelle; Gaidukov, Leonid; Jung, Giyoung et al. · 2020

Full title: Small-molecule control of antibody N-glycosylation in engineered mammalian cells

DOI: https://hdl.handle.net/1721.1/125977

Thesis

Investigating the influence of physiologically relevant hydrostatic pressure on CHO cell batch culture

Shang, Menglin; Kwon, Taehong; Hamel, Jean-Francois P et al. · 2022

Full title: Investigating the influence of physiologically relevant hydrostatic pressure on CHO cell batch culture

Authors: Shang, Menglin; Kwon, Taehong; Hamel, Jean-Francois P; Lim, Chwee Teck; Khoo, Bee Luan; Han, Jongyoon

DOI: https://hdl.handle.net/1721.1/143608

Thesis

Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe et al. · 2016

Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

Authors: López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe; Carrillo-Cocom, Leydi Maribel; Rocha-Pizaña, María del Refugio; Alvarez, Mario Moises

DOI: http://hdl.handle.net/1721.1/105504

Thesis

Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

Sumit, Madhuresh; Dolatshahi, Sepideh; Chu, An-Hsiang Adam et al. · 2020

Full title: Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

DOI: https://hdl.handle.net/1721.1/125974

Thesis

A multi-landing pad DNA integration platform for mammalian cell engineering

Wroblewska, Liliana; Nelson, Tom; Zhang, Xin et al. · 2018

Full title: A multi-landing pad DNA integration platform for mammalian cell engineering

DOI: http://hdl.handle.net/1721.1/115278

Thesis

Preemptive variation reduction in biologic drug substance manufacturing

Güereca Valdivia, Ismael · 2024

Full title: Preemptive variation reduction in biologic drug substance manufacturing

Authors: Güereca Valdivia, Ismael

DOI: https://hdl.handle.net/1721.1/155982

Thesis

Industry 4.0 in Biomanufacturing: Predictive Real-Time Models Using Process Analytical Technology

Murr, Michaela · 2023

Full title: Industry 4.0 in Biomanufacturing: Predictive Real-Time Models Using Process Analytical Technology

Authors: Murr, Michaela

DOI: https://hdl.handle.net/1721.1/151710

Thesis

Continuous Online Protein Quality Monitoring during Perfusion Culture Production Using an Integrated Micro/Nanofluidic System

Kwon, Taehong; Ko, Sung Hee; Hamel, Jean-Francois P et al. · 2020

Full title: Continuous Online Protein Quality Monitoring during Perfusion Culture Production Using an Integrated Micro/Nanofluidic System

Authors: Kwon, Taehong; Ko, Sung Hee; Hamel, Jean-Francois P; Han, Jongyoon

DOI: https://hdl.handle.net/1721.1/125538

Thesis

An Investigation of Multivariate Process Control for Biomanufacturing

Lui, Christopher A. · 2022

Full title: An Investigation of Multivariate Process Control for Biomanufacturing

Authors: Lui, Christopher A.

DOI: https://hdl.handle.net/1721.1/139505

Thesis

Challenging the workhorse: Comparative analysis of eukaryotic micro‐organisms for expressing monoclonal antibodies

Jiang, Hanxiao; Horwitz, Andrew A; Wright, Chapman et al. · 2021

Full title: Challenging the workhorse: Comparative analysis of eukaryotic micro‐organisms for expressing monoclonal antibodies

DOI: https://hdl.handle.net/1721.1/134784

Thesis

Enhancing Production of Recombinant Proteins from Mammalian Cells

Wong, Victor V.T.; Wong, Niki S.C.; Tan, Hong-Kiat et al. · 2003

Full title: Enhancing Production of Recombinant Proteins from Mammalian Cells

Authors: Wong, Victor V.T.; Wong, Niki S.C.; Tan, Hong-Kiat; Wang, Daniel I.C.; Yap, Miranda G.S.

DOI: http://hdl.handle.net/1721.1/3782

Thesis

Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in Komagataella phaffii

Yang, Yuchen; Dalvie, Neil C; Brady, Joseph R et al. · 2025

Full title: Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in Komagataella phaffii

DOI: https://hdl.handle.net/1721.1/163225

Thesis

Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool

Puarattana-aroonkorn, Sitthiphol; Tharakaraman, Kannan; Suriyawipada, Disapan et al. · 2024

Full title: Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool

Authors: Puarattana-aroonkorn, Sitthiphol; Tharakaraman, Kannan; Suriyawipada, Disapan; Ruchirawat, Mathuros; Fuangthong, Mayuree; Sasisekharan, Ram; Artpradit, Charlermchai

DOI: https://hdl.handle.net/1721.1/155543

Thesis

Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel et al. · 2025

Full title: Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Authors: Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel; Dang, Brendan; Wolffe, Lenna A; Atari, Adel; Tseng, Yuen-Yi; Love, J Christopher

DOI: https://hdl.handle.net/1721.1/163220

Thesis

Active Hypothermic Growth: A Novel Means For Increasing Total Interferon-γ Production by Chinese Hamster Ovary Cells

Stephen R., Fox; Yap, Mei Xia; Yap, Miranda G.S. et al. · 2005

Full title: Active Hypothermic Growth: A Novel Means For Increasing Total Interferon-γ Production by Chinese Hamster Ovary Cells

Authors: Stephen R., Fox; Yap, Mei Xia; Yap, Miranda G.S.; Wang, Daniel I.C.

DOI: http://hdl.handle.net/1721.1/30379

Thesis

The Effect of Culture Temperature on Recombinant IFN-γ Production and Quality

Fox, Steven R.; Yap, Miranda G.S.; Wang, Daniel I.C. · 2003

Full title: The Effect of Culture Temperature on Recombinant IFN-γ Production and Quality

Authors: Fox, Steven R.; Yap, Miranda G.S.; Wang, Daniel I.C.

DOI: http://hdl.handle.net/1721.1/3928

Thesis

CIRP Expression on Growth and Productivity of CHO Cells

Tan, Hong-Kiat; Yap, Miranda G.S.; Wang, Daniel I.C. · 2005

Full title: CIRP Expression on Growth and Productivity of CHO Cells

Authors: Tan, Hong-Kiat; Yap, Miranda G.S.; Wang, Daniel I.C.

DOI: http://hdl.handle.net/1721.1/30382

Thesis

Reduced Temperature Production of Recombinant Proteins to Increase Productivity in Mammalian Cell Culture

Fox, Steven R.; Wang, Daniel I.C.; Yap, Miranda G.S. · 2003

Full title: Reduced Temperature Production of Recombinant Proteins to Increase Productivity in Mammalian Cell Culture

Authors: Fox, Steven R.; Wang, Daniel I.C.; Yap, Miranda G.S.

DOI: http://hdl.handle.net/1721.1/3946

Thesis

Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins

Bosques, Carlos J.; Collins, Brian E.; Meador, James W. et al. · 2014

Full title: Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins

DOI: http://hdl.handle.net/1721.1/89032

Thesis

Variability in the Stability and Productivity of Transfected Genes in Chinese Hamster Ovary (CHO) cells

Ng, Say Kong; Yap, Miranda G.S.; Wang, Daniel I.C. · 2004

Full title: Variability in the Stability and Productivity of Transfected Genes in Chinese Hamster Ovary (CHO) cells

Authors: Ng, Say Kong; Yap, Miranda G.S.; Wang, Daniel I.C.

DOI: http://hdl.handle.net/1721.1/7504

Thesis

Naming CHO cells for bio-manufacturing: Genome plasticity and variant phenotypes of cell populations in bioreactors question the relevance of old names

Wurm, Maria J.; Wurm, Florian M. · 2021

Full title: Naming CHO cells for bio-manufacturing: Genome plasticity and variant phenotypes of cell populations in bioreactors question the relevance of old names

Authors: Wurm, Maria J.; Wurm, Florian M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/179941

Thesis

Trimeric SARS-CoV-2 Spike Proteins Produced from CHO Cells in Bioreactors Are High-Quality Antigens

Pino, Paco; Kint, Joeri; Kiseljak, Divor et al. · 2021

Full title: Trimeric SARS-CoV-2 Spike Proteins Produced from CHO Cells in Bioreactors Are High-Quality Antigens

DOI: https://infoscience.epfl.ch/handle/20.500.14299/174671

Thesis

Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection-A Simulation Study

Hernandez Rodriguez, Tanja; Morerod, Sophie; Poertner, Ralf et al. · 2021

Full title: Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection-A Simulation Study

Authors: Hernandez Rodriguez, Tanja; Morerod, Sophie; Poertner, Ralf; Wurm, Florian M.; Frahm, Bjorn

DOI: https://infoscience.epfl.ch/handle/20.500.14299/180009

Thesis

A Robust, High-Titer, Semi-Automated, and In-Culture Antibody-Capturing Transient CHO Platform Technology

Gebhardt, L. P.; Abel, Molica; Zhou, Jing et al. · 2025

Full title: A Robust, High-Titer, Semi-Automated, and In-Culture Antibody-Capturing Transient CHO Platform Technology

DOI: https://infoscience.epfl.ch/handle/20.500.14299/255058

Thesis

Cloning of CHO Cells, Productivity and Genetic Stability—A Discussion

Wurm, Florian · 2020

Full title: Cloning of CHO Cells, Productivity and Genetic Stability—A Discussion

Authors: Wurm, Florian

DOI: https://infoscience.epfl.ch/handle/20.500.14299/169672

Thesis

Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

Muller, N.; Derouazi, M.; Van Tilborgh, F. et al. · 2007

Full title: Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

Authors: Muller, N.; Derouazi, M.; Van Tilborgh, F.; Wulhfard, S.; Hacker, D. L.; Jordan, M.; Wurm, F. M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9754

Thesis

A new approach for identifying positional isomers of glycans cleaved from monoclonal antibodies

Dyukova, Irina; Ben Faleh, Ahmed; Warnke, Stephan et al. · 2021

Full title: A new approach for identifying positional isomers of glycans cleaved from monoclonal antibodies

Authors: Dyukova, Irina; Ben Faleh, Ahmed; Warnke, Stephan; Yalovenko, Natalia; Yatsyna, Vasyl; Bansal, Priyanka; Rizzo, Thomas R.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/179989

Thesis

Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

Zhang, Xiaowei; Garcia, Isabel Fernandez; Baldi, Lucia et al. · 2010

Full title: Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

Authors: Zhang, Xiaowei; Garcia, Isabel Fernandez; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/52051

Thesis

Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells

Davami, Fatemeh; Baldi, Lucia; Rajendra, Yashas et al. · 2014

Full title: Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells

Authors: Davami, Fatemeh; Baldi, Lucia; Rajendra, Yashas; M Wurm, Florian

DOI: https://infoscience.epfl.ch/handle/20.500.14299/108905

Thesis

Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells

Meuwly, F.; von Stockar, U.; Kadouri, A. · 2006

Full title: Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells

Authors: Meuwly, F.; von Stockar, U.; Kadouri, A.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226104

Thesis

OVEREXPRESSION OF SLC15A1 GENE IN CHO-S CELLS TO INCREASE DIPEPTIDE UPTAKE RATE

Liu, Shuman · 2021

Full title: OVEREXPRESSION OF SLC15A1 GENE IN CHO-S CELLS TO INCREASE DIPEPTIDE UPTAKE RATE

Authors: Liu, Shuman

DOI: http://jhir.library.jhu.edu/handle/1774.2/64522

Thesis

HIGH EFFICIENCY AFFINITY CAPTURE AND PURIFICATION OF IMMUNOGLOBULIN G USING MAGNETIC PARTICLES WITH BIOINSPIRIED PEPTIDE LIGANDS

Ou, Shih-Hao · 2019

Full title: HIGH EFFICIENCY AFFINITY CAPTURE AND PURIFICATION OF IMMUNOGLOBULIN G USING MAGNETIC PARTICLES WITH BIOINSPIRIED PEPTIDE LIGANDS

Authors: Ou, Shih-Hao

DOI: http://jhir.library.jhu.edu/handle/1774.2/61606

Thesis

Optimization of Recombinant Protein Production in Different Cell Lines

Ouyang, Chu · 2024

Full title: Optimization of Recombinant Protein Production in Different Cell Lines

Authors: Ouyang, Chu

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/69633

Thesis

Improvement of Erythropoietin N-glycan Branching and Sialylation by Overexpression of Glycosyltransferases

Gao, Yuan · 2016

Full title: Improvement of Erythropoietin N-glycan Branching and Sialylation by Overexpression of Glycosyltransferases

Authors: Gao, Yuan

DOI: http://jhir.library.jhu.edu/handle/1774.2/39421

Thesis

Screening for Antibody Reduction at the Clone Selection Stage to Prevent Reduction During Manufacturing

Lakhani, Aliya Abdulaziz · 2019

Full title: Screening for Antibody Reduction at the Clone Selection Stage to Prevent Reduction During Manufacturing

Authors: Lakhani, Aliya Abdulaziz

DOI: http://jhir.library.jhu.edu/handle/1774.2/60150

Thesis

Protocol for production and expression of chimeric bovine-human monoclonal antibodies

Heydarchi, B; Purcell, DFJ · 2023

Full title: Protocol for production and expression of chimeric bovine-human monoclonal antibodies

Authors: Heydarchi, B; Purcell, DFJ

DOI: https://hdl.handle.net/11343/334751

Thesis

Production and characterization of specific monoclonal antibodies binding the Plasmodium falciparum diagnostic biomarker, histidine-rich protein 2

Leow, CH; Jones, M; Cheng, Q et al. · 2021

Full title: Production and characterization of specific monoclonal antibodies binding the Plasmodium falciparum diagnostic biomarker, histidine-rich protein 2

Authors: Leow, CH; Jones, M; Cheng, Q; Mahler, S; McCarthy, J

DOI: https://hdl.handle.net/11343/277268

Thesis

Impact on product quality of high productive GS-CHO cell lines.

Perani, A; Gloria, B; Wang, D et al. · 2022

Full title: Impact on product quality of high productive GS-CHO cell lines.

Authors: Perani, A; Gloria, B; Wang, D; Murphy, R; Singh, HK; Smyth, FE; Scott, AM

DOI: https://hdl.handle.net/11343/303930

Thesis

A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments

Karimi Alavijeh, M; Lee, YY; Gras, SL · 2024

Full title: A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments

Authors: Karimi Alavijeh, M; Lee, YY; Gras, SL

DOI: https://hdl.handle.net/11343/351093

Thesis

Variations in critical quality attributes (CQAs) on therapeutic monoclonal antibodies (mAbs) due to cultivation conditions, storage conditions and external stress-factors

Nash, Felicia; Sannum, Emma · 2024

Full title: Variations in critical quality attributes (CQAs) on therapeutic monoclonal antibodies (mAbs) due to cultivation conditions, storage conditions and external stress-factors

Authors: Nash, Felicia; Sannum, Emma

DOI: http://lup.lub.lu.se/student-papers/record/9170581

Thesis

Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand

Chua, Gek Kee · 2011

Authors: Chua, Gek Kee

DOI: http://hdl.handle.net/10179/2832

Thesis

FIA-Based Process Monitoring in Simulated Bioreactor for Monoclonal Antibody Production

Fernandez Alcantara, Leonardo Renzo · 2025

Full title: FIA-Based Process Monitoring in Simulated Bioreactor for Monoclonal Antibody Production

Authors: Fernandez Alcantara, Leonardo Renzo

DOI: http://lup.lub.lu.se/student-papers/record/9188201

Thesis

Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening

Kim, Su Hyun; Shin, Seunghyeon; Baek, Minhye et al. · 2023

Full title: Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening

DOI: https://orbit.dtu.dk/en/publications/6d4a73c5-e3ad-45bb-bdcf-fcad2d316ad4

Thesis

High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

Zhang, Ye · 2017

Full title: High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

Authors: Zhang, Ye

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-207600

Thesis

Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium

Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Òdena, Andreu et al. · 2023

Full title: Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium

DOI: https://orbit.dtu.dk/en/publications/9841cea8-7f15-4ec0-9c98-bc7dea65684a

Thesis

Optimization of serum free medium for the production of humanized anti-cea monoclonal antibody.

Ab Latif, Nurzila · 2011

Full title: Optimization of serum free medium for the production of humanized anti-cea monoclonal antibody.

Authors: Ab Latif, Nurzila

DOI: http://psasir.upm.edu.my/id/eprint/26510/2/IB%202011%2030R.pdf

Thesis

A versatile genomic transgenesis platform with enhanced λ integrase for human Expi293F cells

Full title: A versatile genomic transgenesis platform with enhanced λ integrase for human Expi293F cells

DOI: https://phaidra.vetmeduni.ac.at/o:2395

Thesis

Development of a novel bioreactor and systems for suspension cell culture in biopharmaceutical production

Sharma, Rajesh · 2022

Full title: Development of a novel bioreactor and systems for suspension cell culture in biopharmaceutical production

Authors: Sharma, Rajesh

DOI: http://hdl.handle.net/11427/36112

Thesis

Sobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes

Bulté Ocaña, Dubhe Beatriz · 2021

Full title: Sobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes

Authors: Bulté Ocaña, Dubhe Beatriz

DOI: https://hdl.handle.net/20.500.14330/TES01000806237

Thesis

Improving protein yield from mammalian cells by manipulation of stress response pathways

Chalmers, Fiona · 2016

Full title: Improving protein yield from mammalian cells by manipulation of stress response pathways

Authors: Chalmers, Fiona

DOI: https://theses.gla.ac.uk/7666/7/2016ChalmersPhD.pdf

Thesis

Impact de la modification du métabolisme primaire des cellules CHO sur leur productivité

Toussaint, Cecile · 2017

Full title: Impact de la modification du métabolisme primaire des cellules CHO sur leur productivité

Authors: Toussaint, Cecile

DOI: http://hdl.handle.net/1866/18549

Thesis

Recombinant protein production utilising a metallothionein expression system and a Super-CHO cell line

Huang, Edwin P.C. · 2006

Full title: Recombinant protein production utilising a metallothionein expression system and a Super-CHO cell line

Authors: Huang, Edwin P.C.

DOI: http://hdl.handle.net/1959.4/24940

Thesis

Transient production of biopharmaceutical proteins

Wei, Tzu-Hsiang · 2009

Full title: Transient production of biopharmaceutical proteins

Authors: Wei, Tzu-Hsiang

DOI: http://hdl.handle.net/1959.4/43708

Thesis

Effects of imperfect mixing in suspended plant and animal cell cultures

Cheung, Caleb Kin Lok · 2006

Full title: Effects of imperfect mixing in suspended plant and animal cell cultures

Authors: Cheung, Caleb Kin Lok

DOI: http://hdl.handle.net/1959.4/25200

Thesis

The Biological Impact of High Throughput Continuous Bioprocessing

Sewell, David John · 2020

Full title: The Biological Impact of High Throughput Continuous Bioprocessing

Authors: Sewell, David John

DOI: https://www.repository.cam.ac.uk/handle/1810/311711

Thesis

Appendix for: "Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch"

Gangadharan, Nishanthi · 2023

Full title: Appendix for: "Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch"

Authors: Gangadharan, Nishanthi

DOI: https://www.repository.cam.ac.uk/handle/1810/347248

Thesis

A study of apoptosis and cell cycle to augment transfection efficiency in CHO cell lines

Wanandy, Nico Stanislaus · 2007

Full title: A study of apoptosis and cell cycle to augment transfection efficiency in CHO cell lines

Authors: Wanandy, Nico Stanislaus

DOI: http://hdl.handle.net/1959.4/40868

Thesis

Construction, expression and characterisation of a human anti-CD48 monoclonal antibody

Wei, Jiewei · 2006

Full title: Construction, expression and characterisation of a human anti-CD48 monoclonal antibody

Authors: Wei, Jiewei

DOI: http://hdl.handle.net/1959.4/27413

Thesis

Investigation of the factors affecting serum-free growth of the animal cell line CHO K1

Bridges, Michael · 1995

Full title: Investigation of the factors affecting serum-free growth of the animal cell line CHO K1

Authors: Bridges, Michael

DOI: http://hdl.handle.net/1959.4/57409

Thesis

Increasing biomass production in bioreactors applying metabolic analysis and engineering tools

Comas Sanchez, Pere · 2021

Full title: Increasing biomass production in bioreactors applying metabolic analysis and engineering tools

Authors: Comas Sanchez, Pere

DOI: http://hdl.handle.net/10803/671074

Thesis

Development of tools for monitoring and controlling cell cultures through the metabolic analysis

Martínez Monge, Iván · 2018

Full title: Development of tools for monitoring and controlling cell cultures through the metabolic analysis

Authors: Martínez Monge, Iván

DOI: http://hdl.handle.net/10803/664350

Thesis

Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.

Kumpel, Belinda M; Saldova, Radka; Koeleman, Carolien AM et al. · 2021

Full title: Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.

DOI: https://www.repository.cam.ac.uk/handle/1810/316867

Thesis

Enhancing the Functionality of a Microscale Bioreactor System as an Industrial Process Development Tool for Mammalian Perfusion Culture

Sewell, David J; Turner, Richard; Field, Ray et al. · 2019

Full title: Enhancing the Functionality of a Microscale Bioreactor System as an Industrial Process Development Tool for Mammalian Perfusion Culture

Authors: Sewell, David J; Turner, Richard; Field, Ray; Holmes, William; Pradhan, Rahul; Spencer, Christopher; Oliver, Stephen; Slater, Nigel; Dikicioglu, Duygu

DOI: https://www.repository.cam.ac.uk/handle/1810/289313

Thesis

Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.

Traustason, Bergthor; Cheeks, Matthew; Dikicioglu, Duygu · 2020

Full title: Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.

Authors: Traustason, Bergthor; Cheeks, Matthew; Dikicioglu, Duygu

DOI: https://www.repository.cam.ac.uk/handle/1810/301284

Thesis

Challenges and Opportunities for the Large-Scale Chemoenzymatic Glycoengineering of Therapeutic N-Glycosylated Monoclonal Antibodies

Ivanova, Adelina; Falcioni, Francesco · 2022

Full title: Challenges and Opportunities for the Large-Scale Chemoenzymatic Glycoengineering of Therapeutic N-Glycosylated Monoclonal Antibodies

Authors: Ivanova, Adelina; Falcioni, Francesco

DOI: https://www.repository.cam.ac.uk/handle/1810/334145

Thesis

Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Murayyan, Abdulmonem · 2013

Full title: Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Authors: Murayyan, Abdulmonem

DOI: http://hdl.handle.net/10214/6604

Thesis

The Assessment of MAb Quality and Quantity

Drouillard, Gerald · 2015

Full title: The Assessment of MAb Quality and Quantity

Authors: Drouillard, Gerald

DOI: http://hdl.handle.net/10214/8743

Thesis

Genomic and transcriptomic approaches for the advancement of CHO cell bioprocessing

Vishwanathan, Nandita · 2014

Full title: Genomic and transcriptomic approaches for the advancement of CHO cell bioprocessing

Authors: Vishwanathan, Nandita

DOI: http://hdl.handle.net/11299/165110

Thesis

Computational Fluid Dynamics Simulations of Single-Use Bioreactors for the Scale-Up of Cell Culture Processes

Kreitmayer, Diana · 2022

Full title: Computational Fluid Dynamics Simulations of Single-Use Bioreactors for the Scale-Up of Cell Culture Processes

Authors: Kreitmayer, Diana

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/32116/1/DissertationDianaKreitmayer.pdf

Thesis

Methods for cell line and protein engineering

Lundqvist, Magnus · 2018

Full title: Methods for cell line and protein engineering

Authors: Lundqvist, Magnus

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-227195

Thesis

Macroscopic models of Chinese hamster ovary cell cultures

Hagrot, Erika · 2019

Full title: Macroscopic models of Chinese hamster ovary cell cultures

Authors: Hagrot, Erika

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-262850

Thesis

Cell line and protein engineering tools for production and characterization of biologics

Volk, Anna-Luisa · 2017

Full title: Cell line and protein engineering tools for production and characterization of biologics

Authors: Volk, Anna-Luisa

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-212931

Thesis

Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis

Magnetic bead-based isolation of biological therapeutic modalities

Brechmann, Nils A. · 2022

Full title: Magnetic bead-based isolation of biological therapeutic modalities

Authors: Brechmann, Nils A.

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-321336

Thesis

A computational framework for predicting CHO cell culture performance in bioreactors

Cárcamo Behrens, Martín. · 2019

Full title: A computational framework for predicting CHO cell culture performance in bioreactors

Authors: Cárcamo Behrens, Martín.

DOI: https://hdl.handle.net/1721.1/123055

Thesis

Recycling and Regeneration of Spent Perfusion Media via Ion Concentration Polarization

Wynne, Eric Michael · 2025

Full title: Recycling and Regeneration of Spent Perfusion Media via Ion Concentration Polarization

Authors: Wynne, Eric Michael

DOI: https://hdl.handle.net/1721.1/164151

Thesis

Glycosylation site occupancy heterogeneity in Chinese hamster ovary cell culture

Nyberg, Gregg B. (Gregg Bartell), 1970- · 2005

Full title: Glycosylation site occupancy heterogeneity in Chinese hamster ovary cell culture

Authors: Nyberg, Gregg B. (Gregg Bartell), 1970-

DOI: http://hdl.handle.net/1721.1/28190

Thesis

Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays

Rohskopf, Zhumei · 2023

Full title: Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays

Authors: Rohskopf, Zhumei

DOI: https://hdl.handle.net/1721.1/152457

Thesis

Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Maloney, Andrew John · 2025

Full title: Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Authors: Maloney, Andrew John

DOI: https://hdl.handle.net/1721.1/158315

Thesis

Increasing IFN-[gamma] productivity in CHO cells through CDK inhibition

McClain, David Alan · 2010

Full title: Increasing IFN-[gamma] productivity in CHO cells through CDK inhibition

Authors: McClain, David Alan

DOI: http://hdl.handle.net/1721.1/60138

Thesis

Systems Engineering for Viral Vector Manufacturing

Nguyen, Tam Ngoc Thanh · 2023

Full title: Systems Engineering for Viral Vector Manufacturing

Authors: Nguyen, Tam Ngoc Thanh

DOI: https://hdl.handle.net/1721.1/150243

Thesis

Active hypothermic growth : a novel means for increasing total recombinant protein production by CHO cells

Fox, Stephen Richard · 2008

Full title: Active hypothermic growth : a novel means for increasing total recombinant protein production by CHO cells

Authors: Fox, Stephen Richard

DOI: http://dspace.mit.edu/handle/1721.1/32333

Thesis

Comparison of the growth and monoclonal antibody production of suspended mammalian cells in three perfusion systems

Hufford, Kathy (Kathy E.) · 2008

Full title: Comparison of the growth and monoclonal antibody production of suspended mammalian cells in three perfusion systems

Authors: Hufford, Kathy (Kathy E.)

DOI: http://hdl.handle.net/1721.1/39921

Thesis

Molecular, Genetic, and Process Approaches for Improving Secreted Pharmaceutical Protein Quality in Komagataella phaffii

Yang, Yuchen · 2024

Full title: Molecular, Genetic, and Process Approaches for Improving Secreted Pharmaceutical Protein Quality in Komagataella phaffii

Authors: Yang, Yuchen

DOI: https://hdl.handle.net/1721.1/157251

Thesis

Enhancing mammalian bioprocessing through engineering Chinese hamster ovary cell metabolism

Hefzi, Hooman · 2018

Full title: Enhancing mammalian bioprocessing through engineering Chinese hamster ovary cell metabolism

Authors: Hefzi, Hooman

DOI: https://escholarship.org/uc/item/91h2z79t

Thesis

Characterization of the down regulation of antibody production in high cell density perfusion culture

Morrill, Joyce Catherine · 2006

Full title: Characterization of the down regulation of antibody production in high cell density perfusion culture

Authors: Morrill, Joyce Catherine

DOI: http://hdl.handle.net/1721.1/32602

Thesis

Strategies to improve protein production of Chinese hamster ovary cell lines and genome annotation under the guidance of high throughput omics technology

Li, Shangzhong · 2019

Full title: Strategies to improve protein production of Chinese hamster ovary cell lines and genome annotation under the guidance of high throughput omics technology

Authors: Li, Shangzhong

DOI: https://escholarship.org/uc/item/1d30f4xc

Thesis

Molecular dynamics of monoclonal antibody production in high density perfused bioreactors

Buser, Claudia Waltraut · 2008

Full title: Molecular dynamics of monoclonal antibody production in high density perfused bioreactors

Authors: Buser, Claudia Waltraut

DOI: http://hdl.handle.net/1721.1/43915

Thesis

Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Cosenza, Zachary Anthony · 2022

Full title: Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Authors: Cosenza, Zachary Anthony

DOI: https://escholarship.org/uc/item/119489fc

Thesis

Quantitative Analysis of Proteome Dynamics in Chinese Hamster Ovary cells

Florczak, Beata D · 2019

Full title: Quantitative Analysis of Proteome Dynamics in Chinese Hamster Ovary cells

Authors: Florczak, Beata D

DOI: https://etheses.whiterose.ac.uk/id/eprint/25823/1/B.Florczak_thesis.pdf

Thesis

Applications of Protein Engineering in Synthetic Biology and Bioproduction

Minami, Shiaki · 2023

Full title: Applications of Protein Engineering in Synthetic Biology and Bioproduction

Authors: Minami, Shiaki

DOI: https://escholarship.org/uc/item/8p08541h

Thesis

Engineering Oxidative Stress Resistance in CHO Cell Factories

Fairbrass, Danielle L · 2016

Full title: Engineering Oxidative Stress Resistance in CHO Cell Factories

Authors: Fairbrass, Danielle L

DOI: https://etheses.whiterose.ac.uk/id/eprint/16227/1/Master_Copy_DLFairbrassThesis.pdf

Thesis

High-Throughput Platform Development for Chinese Hamster Ovary (CHO) Cell Culture Performance Enhancement Using Small Molecules.

Kalsi, Devika · 2018

Full title: High-Throughput Platform Development for Chinese Hamster Ovary (CHO) Cell Culture Performance Enhancement Using Small Molecules.

Authors: Kalsi, Devika

DOI: https://etheses.whiterose.ac.uk/id/eprint/23127/1/Devika%20Kalsi%20PhD%20Thesis_corrected%20copy.pdf

Thesis

Multigene engineering of secretion in mammalian cell factories

Barber, Nicholas · 2019

Full title: Multigene engineering of secretion in mammalian cell factories

Authors: Barber, Nicholas

DOI: https://etheses.whiterose.ac.uk/id/eprint/25495/1/FINALPDF%20NB%20Jun19%20corrections%20Multigene%20engineering%20of%20secretion%20in%20mammalian%20cell%20factories.pdf

Thesis

Investigating the rules governing N-linked glycosylation of Biologics

Ayre, Josephine · 2023

Full title: Investigating the rules governing N-linked glycosylation of Biologics

Authors: Ayre, Josephine

DOI: https://etheses.whiterose.ac.uk/id/eprint/34913/1/Ayre_204009713_CorrectedThesisClean2.pdf

Thesis

Manipulation of Endoplasmic Reticulum Folding and Assembly Machinery for Improved Production of Complex Biotherapeutics

Swindley, Oscar · 2021

Full title: Manipulation of Endoplasmic Reticulum Folding and Assembly Machinery for Improved Production of Complex Biotherapeutics

Authors: Swindley, Oscar

DOI: https://etheses.whiterose.ac.uk/id/eprint/29353/1/Oscar_Swindley_Thesis_Corrected_FinalAmendment_Aug2021.pdf

Thesis

Screening and development of natural compounds as tools to improve IgG production and quality in recombinant CHO cell culture

Toronjo Urquiza, Luis · 2018

Full title: Screening and development of natural compounds as tools to improve IgG production and quality in recombinant CHO cell culture

Authors: Toronjo Urquiza, Luis

Thesis

Characterisation of Cell Lines with Engineered Golgi Organisation

Spencer, Hannah · 2022

Full title: Characterisation of Cell Lines with Engineered Golgi Organisation

Authors: Spencer, Hannah

DOI: https://etheses.whiterose.ac.uk/id/eprint/31162/1/HannahSpencerThesis.pdf

Thesis

CHO cell multigene engineering by directed evolution

Jawara, Chillel · 2023

Full title: CHO cell multigene engineering by directed evolution

Authors: Jawara, Chillel

DOI: https://etheses.whiterose.ac.uk/id/eprint/36961/1/Jawara_Chillel_190186993_PhDThesis_Final.pdf

Thesis

Using Emerging Next-Generation Sequencing Technologies to Enhance the Lifecycle of Biopharmaceuticals

shamie, isaac · 2022

Full title: Using Emerging Next-Generation Sequencing Technologies to Enhance the Lifecycle of Biopharmaceuticals

Authors: shamie, isaac

DOI: https://escholarship.org/uc/item/55x7t985

Thesis

Integrated cell and bioprocess engineering for rapid and intensive continuous production of biopharmaceuticals

Morgan-Evans, William · 2020

Full title: Integrated cell and bioprocess engineering for rapid and intensive continuous production of biopharmaceuticals

Authors: Morgan-Evans, William

Thesis

Developing novel biosensors for monitoring antibody production in Chinese Hamster Ovary (CHO) cells

Willmott, Jessica · 2022

Full title: Developing novel biosensors for monitoring antibody production in Chinese Hamster Ovary (CHO) cells

Authors: Willmott, Jessica

DOI: https://etheses.whiterose.ac.uk/id/eprint/32583/1/Willmott%2C%20Jessica%2C%20170246628%20-%20Complete%20with%20Corrections.pdf

Thesis

Use of CHO cell synthetic promoters to control transcription of mAb expression vector genes and screening of ER genes for their effect on mAb production

Kerry, William · 2022

Full title: Use of CHO cell synthetic promoters to control transcription of mAb expression vector genes and screening of ER genes for their effect on mAb production

Authors: Kerry, William

DOI: https://etheses.whiterose.ac.uk/id/eprint/32010/2/William%20Kerry%20Corrected%20PhD%20thesis%20November%202022%20minus%20appendix.pdf

Thesis

Adaptation to suspension growth: analysing the surface of suspension growth adapted Chinese hamster ovary cells

Walther, Christa G · 2013

Full title: Adaptation to suspension growth: analysing the surface of suspension growth adapted Chinese hamster ovary cells

Authors: Walther, Christa G

DOI: https://etheses.whiterose.ac.uk/id/eprint/4193/1/final_version_-_all_chapters.pdf

Thesis

Development of an integrated platform for the production of recombinant biopharmaceuticals

Segarra, Camille · 2013

Full title: Development of an integrated platform for the production of recombinant biopharmaceuticals

Authors: Segarra, Camille

DOI: https://etheses.whiterose.ac.uk/id/eprint/4147/1/Segarra_Thesis_PostCorrections.pdf

Thesis

Characterising Chinese Hamster Ovary Cell Extracellular Vesicle Production in Biopharmaceutical Manufacturing

O'Donnell, Fergal · 2022

Full title: Characterising Chinese Hamster Ovary Cell Extracellular Vesicle Production in Biopharmaceutical Manufacturing

Authors: O'Donnell, Fergal

DOI: https://etheses.whiterose.ac.uk/id/eprint/33062/1/Thesis_Corrections.pdf

Thesis

The role of intracellular signalling pathways in CHO cell growth in a synthetic environment

Whitfield, Robert · 2014

Full title: The role of intracellular signalling pathways in CHO cell growth in a synthetic environment

Authors: Whitfield, Robert

DOI: https://etheses.whiterose.ac.uk/id/eprint/6454/1/Rob%20Whitfield%20Final%20Thesis%20Submission.pdf

Thesis

Cell Line and Process Development for Improved Transient Production of a "Difficult-to-Express" Fusion Protein by CHO Cells

Johari, YB · 2015

Full title: Cell Line and Process Development for Improved Transient Production of a "Difficult-to-Express" Fusion Protein by CHO Cells

Authors: Johari, YB

DOI: https://etheses.whiterose.ac.uk/id/eprint/9265/1/PhD%20thesis%20-%20YB%20Johari%20%5BFINAL%5D.pdf

Thesis

Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

Zagari, Francesca · 2012

Full title: Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

Authors: Zagari, Francesca

DOI: https://infoscience.epfl.ch/handle/20.500.14299/84627

Thesis

OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up

Tissot, Stéphanie · 2011

Full title: OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up

Authors: Tissot, Stéphanie

DOI: https://infoscience.epfl.ch/handle/20.500.14299/68752

Thesis

Study of transposon-mediated cell pool and cell line generation in CHO cells

Balasubramanian, Sowmya · 2015

Full title: Study of transposon-mediated cell pool and cell line generation in CHO cells

Authors: Balasubramanian, Sowmya

DOI: https://infoscience.epfl.ch/handle/20.500.14299/113896

Thesis

Influence of cell-line and process conditions on the glycosylation of recombinant proteins

Nahrgang, Stefan · 2005

Full title: Influence of cell-line and process conditions on the glycosylation of recombinant proteins

Authors: Nahrgang, Stefan

DOI: https://infoscience.epfl.ch/handle/20.500.14299/211632

Thesis

Transient gene expression for rapid protein production : studies & optimizations under serum-free conditions

Muller, Natalie · 2005

Full title: Transient gene expression for rapid protein production : studies & optimizations under serum-free conditions

Authors: Muller, Natalie

DOI: https://infoscience.epfl.ch/handle/20.500.14299/214287

Thesis

ELUCIDATING MAMMALIAN CELL METABOLISM USING ‘OMICS TO ENHANCE BIOPROCESS CAPABILITIES

Dhara, Venkata Gayatri · 2022

Full title: ELUCIDATING MAMMALIAN CELL METABOLISM USING ‘OMICS TO ENHANCE BIOPROCESS CAPABILITIES

Authors: Dhara, Venkata Gayatri

DOI: http://jhir.library.jhu.edu/handle/1774.2/66775

Thesis

CELL ENGINEERING AND CULTURE MEDIA MODIFICATION STUDIES TO IMPROVE THE CELL CULTURE PERFORMANCE

Dhara, Venkata Gayatri · 2019

Full title: CELL ENGINEERING AND CULTURE MEDIA MODIFICATION STUDIES TO IMPROVE THE CELL CULTURE PERFORMANCE

Authors: Dhara, Venkata Gayatri

DOI: http://jhir.library.jhu.edu/handle/1774.2/60428

Thesis

Glycoengineering of Chinese Hamster Ovary cells for improving biotherapeutics’ efficacies.

Chung, Cheng-yu · 2019

Full title: Glycoengineering of Chinese Hamster Ovary cells for improving biotherapeutics’ efficacies.

Authors: Chung, Cheng-yu

DOI: http://jhir.library.jhu.edu/handle/1774.2/60731

Thesis

Predictive models for upstream mammalian cell culture development: a review

Yatipanthalawa, BS; Gras, SL · 2023

Full title: Predictive models for upstream mammalian cell culture development: a review

Authors: Yatipanthalawa, BS; Gras, SL

DOI: https://hdl.handle.net/11343/339523

Thesis

Probing Control : Analysis and Design with Application to Fed-Batch Bioreactors

Velut, Stéphane · 2005

Full title: Probing Control : Analysis and Design with Application to Fed-Batch Bioreactors

Authors: Velut, Stéphane

DOI: https://lup.lub.lu.se/record/24605

Thesis

Rapid Media Transition for Metabolic Control Analysis of Fed-Batch Fermentation Processes

Link, Hannes Peter · 2009

Full title: Rapid Media Transition for Metabolic Control Analysis of Fed-Batch Fermentation Processes

Authors: Link, Hannes Peter

DOI: https://mediatum.ub.tum.de/796895

Thesis

Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Hong, Moo Sun · 2022

Full title: Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Authors: Hong, Moo Sun

DOI: https://hdl.handle.net/1721.1/138943

Patent

us-9868940-b2

· 2018

Full title: us-9868940-b2

Patent

us-9650612-b2

· 2017

Full title: us-9650612-b2

Patent

us-re39792-e

· 2007

Full title: us-re39792-e

Patent

us-re41974-e

· 2010

Full title: us-re41974-e

Patent

us-9944968-b2

· 2018

Full title: us-9944968-b2

Patent

us-2017107551-a1

· 2017

Full title: us-2017107551-a1

Patent

us-2017166923-a1

· 2017

Full title: us-2017166923-a1

Patent

us-2017129936-a1

· 2017

Full title: us-2017129936-a1

Patent

us-2017218328-a1

· 2017

Full title: us-2017218328-a1

Patent

us-2017321240-a1

· 2017

Full title: us-2017321240-a1

Patent

us-2017204446-a1

· 2017

Full title: us-2017204446-a1

Patent

us-2017327558-a1

· 2017

Full title: us-2017327558-a1

Patent

us-2018030139-a1

· 2018

Full title: us-2018030139-a1

Patent

us-2018030495-a1

· 2018

Full title: us-2018030495-a1

Patent

us-2018251716-a1

· 2018

Full title: us-2018251716-a1

Patent

us-2018265904-a1

· 2018

Full title: us-2018265904-a1

Patent

us-2018051261-a1

· 2018

Full title: us-2018051261-a1

Patent

us-2019023800-a1

· 2019

Full title: us-2019023800-a1

Patent

us-2018346881-a1

· 2018

Full title: us-2018346881-a1

Patent

us-2018312811-a1

· 2018

Full title: us-2018312811-a1

Patent

us-2019225694-a1

· 2019

Full title: us-2019225694-a1

Patent

us-2019031997-a1

· 2019

Full title: us-2019031997-a1

Patent

us-2019010531-a1

· 2019

Full title: us-2019010531-a1

Patent

us-2019153400-a1

· 2019

Full title: us-2019153400-a1

Patent

us-2019161759-a1

· 2019

Full title: us-2019161759-a1

Patent

us-2019048070-a1

· 2019

Full title: us-2019048070-a1

Patent

us-2019055513-a1

· 2019

Full title: us-2019055513-a1

Patent

us-2019161543-a1

· 2019

Full title: us-2019161543-a1

Patent

us-2019085369-a1

· 2019

Full title: us-2019085369-a1

Patent

us-2019225934-a1

· 2019

Full title: us-2019225934-a1

Patent

us-2019263921-a1

· 2019

Full title: us-2019263921-a1

Patent

us-2019093142-a1

· 2019

Full title: us-2019093142-a1

Patent

us-2019233842-a1

· 2019

Full title: us-2019233842-a1

Patent

us-2019375835-a1

· 2019

Full title: us-2019375835-a1

Patent

us-2020131251-a1

· 2020

Full title: us-2020131251-a1

Patent

us-2020199525-a1

· 2020

Full title: us-2020199525-a1

Patent

us-2020123244-a1

· 2020

Full title: us-2020123244-a1

Patent

us-2019203249-a1

· 2019

Full title: us-2019203249-a1

Patent

us-2019276846-a1

· 2019

Full title: us-2019276846-a1

Patent

us-2020080049-a1

· 2020

Full title: us-2020080049-a1

Patent

us-2020181669-a1

· 2020

Full title: us-2020181669-a1

Patent

us-2020377849-a1

· 2020

Full title: us-2020377849-a1

Patent

us-2020149081-a1

· 2020

Full title: us-2020149081-a1

Patent

us-2020080125-a1

· 2020

Full title: us-2020080125-a1

Patent

us-2021002384-a1

· 2021

Full title: us-2021002384-a1

Patent

us-2020325441-a1

· 2020

Full title: us-2020325441-a1

Patent

us-2020255880-a1

· 2020

Full title: us-2020255880-a1

Patent

us-2020347383-a1

· 2020

Full title: us-2020347383-a1

Patent

us-2020223913-a1

· 2020

Full title: us-2020223913-a1

Patent

us-2021222109-a1

· 2021

Full title: us-2021222109-a1

Patent

us-2021009988-a1

· 2021

Full title: us-2021009988-a1

Patent

us-2021017553-a1

· 2021

Full title: us-2021017553-a1

Patent

us-2021002646-a1

· 2021

Full title: us-2021002646-a1

Patent

us-2021214702-a1

· 2021

Full title: us-2021214702-a1

Patent

us-2021087535-a1

· 2021

Full title: us-2021087535-a1

Patent

us-2021292783-a1

· 2021

Full title: us-2021292783-a1

Patent

us-2021238644-a1

· 2021

Full title: us-2021238644-a1

Patent

us-2021253996-a1

· 2021

Full title: us-2021253996-a1

Patent

us-2021332402-a1

· 2021

Full title: us-2021332402-a1

Patent

us-2021317435-a1

· 2021

Full title: us-2021317435-a1

Patent

us-2021388407-a1

· 2021

Full title: us-2021388407-a1

Patent

us-2021317395-a1

· 2021

Full title: us-2021317395-a1

Patent

us-2021246478-a1

· 2021

Full title: us-2021246478-a1

Patent

us-2021381020-a1

· 2021

Full title: us-2021381020-a1

Patent

us-2021254050-a1

· 2021

Full title: us-2021254050-a1

Patent

us-2021380923-a1

· 2021

Full title: us-2021380923-a1

Patent

us-2022089775-a1

· 2022

Full title: us-2022089775-a1

Patent

us-2021340481-a1

· 2021

Full title: us-2021340481-a1

Patent

us-2022154207-a1

· 2022

Full title: us-2022154207-a1

Patent

us-2021324098-a1

· 2021

Full title: us-2021324098-a1

Patent

us-2022154137-a1

· 2022

Full title: us-2022154137-a1

Patent

us-2022089761-a1

· 2022

Full title: us-2022089761-a1

Patent

us-2022064591-a1

· 2022

Full title: us-2022064591-a1

Patent

us-2022195478-a1

· 2022

Full title: us-2022195478-a1

Patent

us-2022228107-a1

· 2022

Full title: us-2022228107-a1

Patent

us-2022220509-a1

· 2022

Full title: us-2022220509-a1

Patent

us-2022228187-a1

· 2022

Full title: us-2022228187-a1

Patent

us-2022315644-a1

· 2022

Full title: us-2022315644-a1

Patent

us-2022348977-a1

· 2022

Full title: us-2022348977-a1

Patent

us-2022333054-a1

· 2022

Full title: us-2022333054-a1

Patent

us-2022315887-a1

· 2022

Full title: us-2022315887-a1

Patent

us-2022282298-a1

· 2022

Full title: us-2022282298-a1

Patent

us-2022396776-a1

· 2022

Full title: us-2022396776-a1

Patent

us-2023235062-a1

· 2023

Full title: us-2023235062-a1

Patent

us-2022372436-a1

· 2022

Full title: us-2022372436-a1

Patent

us-2023203449-a1

· 2023

Full title: us-2023203449-a1

Patent

us-2023193341-a1

· 2023

Full title: us-2023193341-a1

Patent

us-2022380827-a1

· 2022

Full title: us-2022380827-a1

Patent

us-2023106023-a1

· 2023

Full title: us-2023106023-a1

Patent

us-2023313125-a1

· 2023

Full title: us-2023313125-a1

Patent

us-2023250399-a1

· 2023

Full title: us-2023250399-a1

Patent

us-2023331776-a1

· 2023

Full title: us-2023331776-a1

Patent

us-2023332201-a1

· 2023

Full title: us-2023332201-a1

Patent

us-2023234995-a1

· 2023

Full title: us-2023234995-a1

Patent

us-2023287043-a1

· 2023

Full title: us-2023287043-a1

Patent

us-2023235318-a1

· 2023

Full title: us-2023235318-a1

Patent

us-2023287322-a1

· 2023

Full title: us-2023287322-a1

Patent

us-2023348532-a1

· 2023

Full title: us-2023348532-a1

Patent

us-2024002772-a1

· 2024

Full title: us-2024002772-a1

Patent

us-2023365920-a1

· 2023

Full title: us-2023365920-a1

Patent

us-2023332198-a1

· 2023

Full title: us-2023332198-a1

Patent

us-2024043879-a1

· 2024

Full title: us-2024043879-a1

Patent

us-2023323421-a1

· 2023

Full title: us-2023323421-a1

Patent

us-2023332084-a1

· 2023

Full title: us-2023332084-a1

Patent

us-2024010737-a1

· 2024

Full title: us-2024010737-a1

Patent

us-2024132835-a1

· 2024

Full title: us-2024132835-a1

Patent

us-2023374064-a1

· 2023

Full title: us-2023374064-a1

Patent

us-2024076626-a1

· 2024

Full title: us-2024076626-a1

Patent

us-2024002483-a1

· 2024

Full title: us-2024002483-a1

Patent

us-2024167006-a1

· 2024

Full title: us-2024167006-a1

Patent

us-2024093143-a1

· 2024

Full title: us-2024093143-a1

Patent

us-2024228948-a9

· 2024

Full title: us-2024228948-a9

Patent

us-2024093248-a1

· 2024

Full title: us-2024093248-a1

Patent

us-2024174752-a1

· 2024

Full title: us-2024174752-a1

Patent

us-2024010709-a1

· 2024

Full title: us-2024010709-a1

Patent

us-2024083972-a1

· 2024

Full title: us-2024083972-a1

Patent

us-2024052392-a1

· 2024

Full title: us-2024052392-a1

Patent

us-2024425894-a1

· 2024

Full title: us-2024425894-a1

Patent

us-2024309073-a1

· 2024

Full title: us-2024309073-a1

Patent

us-2024287207-a1

· 2024

Full title: us-2024287207-a1

Patent

us-2024318114-a1

· 2024

Full title: us-2024318114-a1

Patent

us-2024287152-a1

· 2024

Full title: us-2024287152-a1

Patent

us-2025034521-a1

· 2025

Full title: us-2025034521-a1

Patent

us-2024158754-a1

· 2024

Full title: us-2024158754-a1

Patent

us-2025019419-a1

· 2025

Full title: us-2025019419-a1

Patent

us-2024392315-a1

· 2024

Full title: us-2024392315-a1

Patent

us-2025066491-a1

· 2025

Full title: us-2025066491-a1

Patent

us-2025059486-a1

· 2025

Full title: us-2025059486-a1

Patent

us-2025027051-a1

· 2025

Full title: us-2025027051-a1

Patent

us-2025066493-a1

· 2025

Full title: us-2025066493-a1

Patent

us-2024400658-a1

· 2024

Full title: us-2024400658-a1

Patent

us-2025066718-a1

· 2025

Full title: us-2025066718-a1

Patent

us-2025087302-a1

· 2025

Full title: us-2025087302-a1

Patent

us-2025136705-a1

· 2025

Full title: us-2025136705-a1

Patent

us-2025101402-a1

· 2025

Full title: us-2025101402-a1

Patent

us-2025075172-a1

· 2025

Full title: us-2025075172-a1

Patent

us-2025059501-a1

· 2025

Full title: us-2025059501-a1

Patent

us-2025154229-a1

· 2025

Full title: us-2025154229-a1

Patent

us-2025101355-a1

· 2025

Full title: us-2025101355-a1

Patent

us-2025154470-a1

· 2025

Full title: us-2025154470-a1

Patent

us-2025145934-a1

· 2025

Full title: us-2025145934-a1

Patent

us-2025263770-a1

· 2025

Full title: us-2025263770-a1

Patent

us-2025326820-a1

· 2025

Full title: us-2025326820-a1

Patent

us-2025171732-a1

· 2025

Full title: us-2025171732-a1

Patent

us-4724206-a

· 1988

Full title: us-4724206-a

Patent

us-2025283068-a1

· 2025

Full title: us-2025283068-a1

Patent

us-5122469-a

· 1992

Full title: us-5122469-a

Patent

us-2011189734-a1

· 2011

Full title: us-2011189734-a1

Patent

us-2011117087-a1

· 2011

Full title: us-2011117087-a1

Patent

us-2012190068-a1

· 2012

Full title: us-2012190068-a1

Patent

us-2012231500-a1

· 2012

Full title: us-2012231500-a1

Patent

us-2012190061-a1

· 2012

Full title: us-2012190061-a1

Patent

us-2013017577-a1

· 2013

Full title: us-2013017577-a1

Patent

us-2012190005-a1

· 2012

Full title: us-2012190005-a1

Patent

us-2012129727-a1

· 2012

Full title: us-2012129727-a1

Patent

us-2013084593-a1

· 2013

Full title: us-2013084593-a1

Patent

us-2013102032-a1

· 2013

Full title: us-2013102032-a1

Patent

us-2013143238-a1

· 2013

Full title: us-2013143238-a1

Patent

us-2013149300-a1

· 2013

Full title: us-2013149300-a1

Patent

us-2014087424-a1

· 2014

Full title: us-2014087424-a1

Patent

us-2013266985-a1

· 2013

Full title: us-2013266985-a1

Patent

us-2013316434-a1

· 2013

Full title: us-2013316434-a1

Patent

us-2014038264-a1

· 2014

Full title: us-2014038264-a1

Patent

us-2014099711-a1

· 2014

Full title: us-2014099711-a1

Patent

us-2014106405-a1

· 2014

Full title: us-2014106405-a1

Patent

us-2014302581-a1

· 2014

Full title: us-2014302581-a1

Patent

us-2015044719-a1

· 2015

Full title: us-2015044719-a1

Patent

us-2015044769-a1

· 2015

Full title: us-2015044769-a1

Patent

us-2015299638-a1

· 2015

Full title: us-2015299638-a1

Patent

us-2014273095-a1

· 2014

Full title: us-2014273095-a1

Patent

us-2015140607-a1

· 2015

Full title: us-2015140607-a1

Patent

us-2015218509-a1

· 2015

Full title: us-2015218509-a1

Patent

us-2016237399-a1

· 2016

Full title: us-2016237399-a1

Patent

us-2016076002-a1

· 2016

Full title: us-2016076002-a1

Patent

us-2016185847-a1

· 2016

Full title: us-2016185847-a1

Patent

us-2016244726-a1

· 2016

Full title: us-2016244726-a1

Patent

us-2016289633-a1

· 2016

Full title: us-2016289633-a1

Patent

us-2016186228-a1

· 2016

Full title: us-2016186228-a1

Patent

us-2016108357-a1

· 2016

Full title: us-2016108357-a1

Patent

us-2016230204-a1

· 2016

Full title: us-2016230204-a1

Patent

us-2016312179-a1

· 2016

Full title: us-2016312179-a1

Patent

us-2017016043-a1

· 2017

Full title: us-2017016043-a1

Patent

us-2016244725-a1

· 2016

Full title: us-2016244725-a1

Patent

us-2016355572-a1

· 2016

Full title: us-2016355572-a1

Patent

us-2016304928-a1

· 2016

Full title: us-2016304928-a1

Patent

us-2017017891-a1

· 2017

Full title: us-2017017891-a1

Patent

us-2017009269-a1

· 2017

Full title: us-2017009269-a1

Patent

us-2017088873-a1

· 2017

Full title: us-2017088873-a1

Patent

us-2017051309-a1

· 2017

Full title: us-2017051309-a1

Patent

us-2017129937-a1

· 2017

Full title: us-2017129937-a1

Patent

us-10030064-b2

· 2018

Full title: us-10030064-b2

Patent

us-10119118-b2

· 2018

Full title: us-10119118-b2

Patent

us-10059754-b2

· 2018

Full title: us-10059754-b2

Patent

us-10118966-b2

· 2018

Full title: us-10118966-b2

Patent

us-10119117-b2

· 2018

Full title: us-10119117-b2

Patent

us-10233231-b2

· 2019

Full title: us-10233231-b2

Patent

us-10738334-b2

· 2020

Full title: us-10738334-b2

Patent

us-10196665-b2

· 2019

Full title: us-10196665-b2

Patent

us-10435464-b1

· 2019

Full title: us-10435464-b1

Patent

us-10590455-b2

· 2020

Full title: us-10590455-b2

Patent

us-10494421-b2

· 2019

Full title: us-10494421-b2

Patent

us-10676772-b2

· 2020

Full title: us-10676772-b2

Patent

us-10745672-b2

· 2020

Full title: us-10745672-b2

Patent

us-10501769-b2

· 2019

Full title: us-10501769-b2

Patent

us-10982003-b2

· 2021

Full title: us-10982003-b2

Patent

us-11014981-b2

· 2021

Full title: us-11014981-b2

Patent

us-10816477-b2

· 2020

Full title: us-10816477-b2

Patent

us-10961556-b2

· 2021

Full title: us-10961556-b2

Patent

us-10808272-b2

· 2020

Full title: us-10808272-b2

Patent

us-11021728-b2

· 2021

Full title: us-11021728-b2

Patent

us-11136610-b2

· 2021

Full title: us-11136610-b2

Patent

us-11377678-b2

· 2022

Full title: us-11377678-b2

Patent

us-10988761-b2

· 2021

Full title: us-10988761-b2

Patent

us-11377677-b2

· 2022

Full title: us-11377677-b2

Patent

us-11332771-b2

· 2022

Full title: us-11332771-b2

Patent

us-11104875-b2

· 2021

Full title: us-11104875-b2

Patent

us-11390663-b2

· 2022

Full title: us-11390663-b2

Patent

us-11390839-b2

· 2022

Full title: us-11390839-b2

Patent

us-11505784-b2

· 2022

Full title: us-11505784-b2

Patent

us-11292829-b2

· 2022

Full title: us-11292829-b2

Patent

us-11718864-b2

· 2023

Full title: us-11718864-b2

Patent

us-11396540-b1

· 2022

Full title: us-11396540-b1

Patent

us-11401509-b2

· 2022

Full title: us-11401509-b2

Patent

us-11254964-b1

· 2022

Full title: us-11254964-b1

Patent

us-11655457-b2

· 2023

Full title: us-11655457-b2

Patent

us-11702628-b2

· 2023

Full title: us-11702628-b2

Patent

us-11970724-b2

· 2024

Full title: us-11970724-b2

Patent

us-12103975-b2

· 2024

Full title: us-12103975-b2

Patent

us-12031151-b2

· 2024

Full title: us-12031151-b2

Patent

us-12195712-b2

· 2025

Full title: us-12195712-b2

Patent

us-12234483-b2

· 2025

Full title: us-12234483-b2

Patent

us-12331341-b2

· 2025

Full title: us-12331341-b2

Patent

us-12043845-b2

· 2024

Full title: us-12043845-b2

Patent

us-12163122-b2

· 2024

Full title: us-12163122-b2

Patent

us-12202906-b2

· 2025

Full title: us-12202906-b2

Patent

us-12286619-b2

· 2025

Full title: us-12286619-b2

Patent

us-12415980-b2

· 2025

Full title: us-12415980-b2

Patent

us-12351641-b2

· 2025

Full title: us-12351641-b2

Patent

us-12291563-b2

· 2025

Full title: us-12291563-b2

Patent

us-2002182208-a1

· 2002

Full title: us-2002182208-a1

Patent

us-2002019031-a1

· 2002

Full title: us-2002019031-a1

Patent

us-2003035799-a1

· 2003

Full title: us-2003035799-a1

Patent

us-12371656-b2

· 2025

Full title: us-12371656-b2

Patent

us-2002119530-a1

· 2002

Full title: us-2002119530-a1

Patent

us-2003235898-a1

· 2003

Full title: us-2003235898-a1

Patent

us-2004175798-a1

· 2004

Full title: us-2004175798-a1

Patent

us-2004048368-a1

· 2004

Full title: us-2004048368-a1

Patent

us-2003087372-a1

· 2003

Full title: us-2003087372-a1

Patent

us-2005272124-a1

· 2005

Full title: us-2005272124-a1

Patent

us-2005019859-a1

· 2005

Full title: us-2005019859-a1

Patent

us-2004137000-a1

· 2004

Full title: us-2004137000-a1

Patent

us-2005191697-a1

· 2005

Full title: us-2005191697-a1

Patent

us-2004228857-a1

· 2004

Full title: us-2004228857-a1

Patent

us-2004077086-a1

· 2004

Full title: us-2004077086-a1

Patent

us-2005070013-a1

· 2005

Full title: us-2005070013-a1

Patent

us-2006121444-a1

· 2006

Full title: us-2006121444-a1

Patent

us-2005221393-a1

· 2005

Full title: us-2005221393-a1

Patent

us-2005277132-a1

· 2005

Full title: us-2005277132-a1

Patent

us-2006121568-a1

· 2006

Full title: us-2006121568-a1

Patent

us-2006115901-a1

· 2006

Full title: us-2006115901-a1

Patent

us-2006121569-a1

· 2006

Full title: us-2006121569-a1

Patent

us-2006160180-a1

· 2006

Full title: us-2006160180-a1

Patent

us-2008108553-a1

· 2008

Full title: us-2008108553-a1

Patent

us-2008031873-a1

· 2008

Full title: us-2008031873-a1

Patent

us-2008131934-a1

· 2008

Full title: us-2008131934-a1

Patent

us-2008279852-a1

· 2008

Full title: us-2008279852-a1

Patent

us-2009023186-a1

· 2009

Full title: us-2009023186-a1

Patent

us-2009221003-a1

· 2009

Full title: us-2009221003-a1

Patent

us-2009042253-a1

· 2009

Full title: us-2009042253-a1

Patent

us-2010035342-a1

· 2010

Full title: us-2010035342-a1

Patent

us-2010086947-a1

· 2010

Full title: us-2010086947-a1

Patent

us-2010221781-a1

· 2010

Full title: us-2010221781-a1

Patent

us-2011081679-a1

· 2011

Full title: us-2011081679-a1

Patent

us-2011217772-a1

· 2011

Full title: us-2011217772-a1

Patent

us-2011086411-a1

· 2011

Full title: us-2011086411-a1

Patent

us-2011104734-a1

· 2011

Full title: us-2011104734-a1

Patent

us-2011250644-a1

· 2011

Full title: us-2011250644-a1

Patent

us-2012015438-a1

· 2012

Full title: us-2012015438-a1

Patent

us-5545405-a

· 1996

Full title: us-5545405-a

Patent

us-5316938-a

· 1994

Full title: us-5316938-a

Patent

us-5545404-a

· 1996

Full title: us-5545404-a

Patent

us-5633162-a

· 1997

Full title: us-5633162-a

Patent

us-5545403-a

· 1996

Full title: us-5545403-a

Patent

us-5856179-a

· 1999

Full title: us-5856179-a

Patent

us-5911989-a

· 1999

Full title: us-5911989-a

Patent

us-5672502-a

· 1997

Full title: us-5672502-a

Patent

us-6238891-b1

· 2001

Full title: us-6238891-b1

Patent

us-6180401-b1

· 2001

Full title: us-6180401-b1

Patent

us-6268484-b1

· 2001

Full title: us-6268484-b1

Patent

us-6905847-b2

· 2005

Full title: us-6905847-b2

Patent

us-7070960-b2

· 2006

Full title: us-7070960-b2

Patent

us-6458565-b1

· 2002

Full title: us-6458565-b1

Patent

us-7294484-b2

· 2007

Full title: us-7294484-b2

Patent

us-7429491-b2

· 2008

Full title: us-7429491-b2

Patent

us-7291484-b2

· 2007

Full title: us-7291484-b2

Patent

us-7541164-b2

· 2009

Full title: us-7541164-b2

Patent

us-7335491-b2

· 2008

Full title: us-7335491-b2

Patent

us-7569339-b2

· 2009

Full title: us-7569339-b2

Patent

us-7955833-b2

· 2011

Full title: us-7955833-b2

Patent

us-7300773-b2

· 2007

Full title: us-7300773-b2

Patent

us-8580554-b2

· 2013

Full title: us-8580554-b2

Patent

us-8399249-b2

· 2013

Full title: us-8399249-b2

Patent

us-8206981-b2

· 2012

Full title: us-8206981-b2

Patent

us-8232075-b2

· 2012

Full title: us-8232075-b2

Patent

us-8524497-b2

· 2013

Full title: us-8524497-b2

Patent

us-9068970-b2

· 2015

Full title: us-9068970-b2

Patent

us-8765415-b2

· 2014

Full title: us-8765415-b2

Patent

us-8986957-b2

· 2015

Full title: us-8986957-b2

Patent

us-8969043-b2

· 2015

Full title: us-8969043-b2

Patent

us-9163211-b2

· 2015

Full title: us-9163211-b2

Patent

us-9334489-b2

· 2016

Full title: us-9334489-b2

Patent

us-9260695-b2

· 2016

Full title: us-9260695-b2

Patent

us-9469865-b2

· 2016

Full title: us-9469865-b2

Patent

us-9340814-b2

· 2016

Full title: us-9340814-b2

Patent

us-9243224-b2

· 2016

Full title: us-9243224-b2

Patent

us-9540426-b2

· 2017

Full title: us-9540426-b2

Patent

us-2014329277-a1

· 2014

Full title: us-2014329277-a1

3. Authors & Profiles

Run data extraction first

Find authors first. Run extraction before finding authors.

4. Email Outreach

Generate emails first. Find authors, then generate emails.

Monoclonal Antibody Production Optimization In Cho

1. Documents

Full text available

Metadata only

2. Data Extraction

3. Authors & Profiles

4. Email Outreach

Settings

Edit Email