Evidence For Senolytic Drugs In Age Related Diseas

Paper SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

Utkarsh Tripathi; R. Nchioua; L. Prata et al. · 2021 · Aging · DOI

Full title: SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

Authors: Utkarsh Tripathi; R. Nchioua; L. Prata; Yi Zhu; E. Gerdes; N. Giorgadze; T. Pirtskhalava; Erik S. Parker; A. Xue; J. Espindola-Netto; S. Stenger; P. Robbins; L. Niedernhofer; S. Dickinson; D. B. Allison; F. Kirchhoff; K. Sparrer; T. Tchkonia; J. Kirkland

Year: 2021

Venue: Aging

DOI: https://doi.org/10.18632/aging.203560

Paper Senescence-associated tumor growth is promoted by 12-Lipoxygenase

Shilpa Patil; Jessica L. Reedy; B. Scroggins et al. · 2022 · Aging · DOI

Full title: Senescence-associated tumor growth is promoted by 12-Lipoxygenase

Authors: Shilpa Patil; Jessica L. Reedy; B. Scroggins; Ayla O. White; S. Kwon; U. Shankavaram; Alfonso López-Coral; E. Chung; D. Citrin

Year: 2022

Venue: Aging

DOI: https://doi.org/10.18632/aging.203890

Paper Enhanced co-culture and enrichment of human natural killer cells for the selective clearance of senescent cells

Kim, Kristie; Admasu, Tesfahun Dessale; Stolzing, Alexandra et al. · 2022 · Aging · DOI

Full title: Enhanced co-culture and enrichment of human natural killer cells for the selective clearance of senescent cells

Authors: Kim, Kristie; Admasu, Tesfahun Dessale; Stolzing, Alexandra; Sharma, Amit

Year: 2022

Venue: Aging

DOI: https://doi.org/10.18632/aging.203931

Paper The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial

Hachmo, Yafit; Hadanny, Amir; Mendelovic, Sonia et al. · 2021 · Aging · DOI

Full title: The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial

Authors: Hachmo, Yafit; Hadanny, Amir; Mendelovic, Sonia; Hillman, Pnina; Shapira, Eyal; Landau, Geva; Gattegno, Hadar; Zrachya, Avi; Daniel-Kotovsky, Malka; Catalogna, Merav; Fishlev, Gregory; Lang, Erez; Polak, Nir; Doenyas, Keren; Friedman, Mony; Zemel, Yonatan; Bechor, Yair; Efrati, Shai

Year: 2021

Venue: Aging

DOI: https://doi.org/10.18632/aging.203701

Paper Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial.

Hachmo, Yafit; Hadanny, Amir; Abu Hamed, Ramzia et al. · 2020 · Aging · DOI

Full title: Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial.

Authors: Hachmo, Yafit; Hadanny, Amir; Abu Hamed, Ramzia; Daniel-Kotovsky, Malka; Catalogna, Merav; Fishlev, Gregory; Lang, Erez; Polak, Nir; Doenyas, Keren; Friedman, Mony; Zemel, Yonatan; Bechor, Yair; Efrati, Shai

Year: 2020

Venue: Aging

DOI: https://doi.org/10.18632/aging.202188

Paper Exploring aging interventions in human brain organoids

Julio Aguado; E. Wolvetang · 2022 · Aging · DOI

Full title: Exploring aging interventions in human brain organoids

Authors: Julio Aguado; E. Wolvetang

Year: 2022

Venue: Aging

DOI: https://doi.org/10.18632/aging.203925

Paper Aryl hydrocarbon receptor blocks aging-induced senescence in the liver and fibroblast cells.

Nacarino-Palma, Ana; Rico-Leo, Eva M; Campisi, Judith et al. · 2022 · Aging · DOI

Full title: Aryl hydrocarbon receptor blocks aging-induced senescence in the liver and fibroblast cells.

Authors: Nacarino-Palma, Ana; Rico-Leo, Eva M; Campisi, Judith; Ramanathan, Arvind; González-Rico, Francisco J; Rejano-Gordillo, Claudia M; Ordiales-Talavero, Ana; Merino, Jaime M; Fernández-Salguero, Pedro M

Year: 2022

Venue: Aging

Paper Targeting proteostasis maintenance and autophagy in senescence

Valentin L'Hôte; C. Mann; J. Thuret · 2022 · Aging · DOI

Full title: Targeting proteostasis maintenance and autophagy in senescence

Authors: Valentin L'Hôte; C. Mann; J. Thuret

Year: 2022

Venue: Aging

DOI: https://doi.org/10.18632/aging.203941

Paper Elucidating the anti-aging mechanism of Si Jun Zi Tang by integrating network pharmacology and experimental validation in vivo

Yuan, Yang; Zhang, Yanghuan; Zheng, Runzi et al. · 2022 · Aging · DOI

Full title: Elucidating the anti-aging mechanism of Si Jun Zi Tang by integrating network pharmacology and experimental validation in vivo

Authors: Yuan, Yang; Zhang, Yanghuan; Zheng, Runzi; Yuan, Hongjun; Zhou, Ruoyu; Jia, Shuting; Liu, Jing

Year: 2022

Venue: Aging

DOI: https://doi.org/10.18632/aging.204055

Paper Moderate-vigorous physical activity attenuates premature senescence of immune cells in sedentary adults with obesity: a pilot randomized controlled trial

Xiang-Ke Chen; Chen Zheng; S. Wong et al. · 2022 · Aging · DOI

Full title: Moderate-vigorous physical activity attenuates premature senescence of immune cells in sedentary adults with obesity: a pilot randomized controlled trial

Authors: Xiang-Ke Chen; Chen Zheng; S. Wong; A. Ma

Year: 2022

Venue: Aging

DOI: https://doi.org/10.18632/aging.204458

Paper Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic.

Al-Mansour, Fares; Alraddadi, Abdullah; He, Buwei et al. · 2023 · Aging · DOI

Full title: Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic.

Authors: Al-Mansour, Fares; Alraddadi, Abdullah; He, Buwei; Saleh, Anes; Poblocka, Marta; Alzahrani, Wael; Cowley, Shaun; Macip, Salvador

Year: 2023

Venue: Aging

DOI: https://doi.org/10.18632/aging.204616

Paper Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle

Lei Liu; Xianlin Yue; Zewei Sun et al. · 2022 · Aging · DOI

Full title: Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle

Authors: Lei Liu; Xianlin Yue; Zewei Sun; W. S. Hambright; Q. Feng; Yan Cui; J. Huard; P. Robbins; Zhihui Wang; Xiaodong Mu

Year: 2022

Venue: Aging

DOI: https://doi.org/10.18632/aging.204275

Paper Meeting Report: Aging Research and Drug Discovery

Meron, Esther; Thaysen, Maria; Angeli, Suzanne et al. · 2022 · Aging · DOI

Full title: Meeting Report: Aging Research and Drug Discovery

Authors: Meron, Esther; Thaysen, Maria; Angeli, Suzanne; Antebi, Adam; Barzilai, Nir; Baur, Joseph A.; Bekker‐Jensen, Simon; Birkisdóttir, María B.; Bischof, Evelyne; Bruening, Jens; Brunet, Anne; Buchwalter, Abigail; Cabreiro, Filipe; Cai, Shi‐Qing; Chen, Brian H.; Ermolaeva, Maria; Ewald, Collin Y.; Ferrucci, Luigi; Florian, Maria Carolina; Fortney, Kristen; Freund, Adam; Georgievskaya, Anastasia; Gladyshev, Vadim N.; Glass, David J.; Golato, Tyler; Gorbunova, Vera; Hoejimakers, Jan; Houtkooper, Riekelt H.; Jäger, Sibylle; Jaksch, Frank; Janssens, Georges E.; Jensen, Martin Borch; Kaeberlein, Matt; Karsenty, Gérard; Keizer, Peter L.J. de; Kennedy, Brian K.; Kirkland, James L.; Kjær, Michael; Kroemer, Guido; Lee, Kai-Fu; Lemaı̂tre, Jean-Marc; Liaskos, David; Longo, Valter D.; Lu, Yuxuan; MacArthur, Michael R.; Maier, Andrea B.; Manakanatas, Christina; Mitchell, Sarah J.; Moskalev, Alexey; Niedernhofer, Laura J.; Ozerov, Ivan V.; Partridge, Linda; Passegué, Emmanuelle; Petr, Michael; Peyer, James; Radenković, Dina; Rando, Thomas A.; Rattan, Suresh I. S.; Riedel, Christian G.; Rudolph, K. Lenhard; Ai, Ruixue; Serrano, Manuel; Schumacher, Björn; Sinclair, David; Smith, Ryan; Suh, Yousin; Taub, Pam R.; Trapp, Alexandre; Trendelenburg, Anne‐Ulrike; Valenzano, Dario Riccardo; Verburgh, Kris; Verdin, Eric; Vijg, Jan; Westendorp, Rudi G. J.; Zonari, Alessandra; Bakula, Daniela; Zhavoronkov, Alex; Scheibye‐Knudsen, Morten

Year: 2022

Venue: Aging

DOI: https://doi.org/10.18632/aging.203859

Paper Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells.

Rysanek, David; Vasicova, Pavla; Kolla, Jayaprakash Narayana et al. · 2022 · Aging · DOI

Full title: Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells.

Authors: Rysanek, David; Vasicova, Pavla; Kolla, Jayaprakash Narayana; Sedlak, David; Andera, Ladislav; Bartek, Jiri; Hodny, Zdenek

Year: 2022

Venue: Aging

DOI: https://doi.org/10.18632/aging.204207

Paper Glutaminase inhibitors rejuvenate human skin via clearance of senescent cells: a study using a mouse/human chimeric model

Takaya, Kento; Ishii, Tatsuyuki; Asou, Toru et al. · 2022 · Aging · DOI

Full title: Glutaminase inhibitors rejuvenate human skin via clearance of senescent cells: a study using a mouse/human chimeric model

Authors: Takaya, Kento; Ishii, Tatsuyuki; Asou, Toru; Kishi, Kazuo

Year: 2022

Venue: Aging

DOI: https://doi.org/10.18632/aging.204391

Paper In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

Parinya Samakkarnthai; D. Saul; Lei Zhang et al. · 2023 · Aging · DOI

Full title: In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

Authors: Parinya Samakkarnthai; D. Saul; Lei Zhang; Zaira Aversa; Madison L. Doolittle; J. Sfeir; J. Kaur; E. Atkinson; J. Edwards; Graham G. Russell; R. Pignolo; J. Kirkland; T. Tchkonia; L. Niedernhofer; D. Monroe; N. LeBrasseur; J. Farr; P. Robbins; S. Khosla

Year: 2023

Venue: Aging

DOI: https://doi.org/10.18632/aging.204701

Paper Development of a DNA damage-induced senescence model in osteoarthritic chondrocytes

Georget, Mélina; Defois, A.; Guiho, Romain et al. · 2023 · Aging · DOI

Full title: Development of a DNA damage-induced senescence model in osteoarthritic chondrocytes

Authors: Georget, Mélina; Defois, A.; Guiho, Romain; Bon, Nina; Allain‐Maillet, Sophie; Boyer, Cécile; Halgand, Boris; Waast, Denis; Grimandi, G.; Fouasson‐Chailloux, Alban; Guicheux, Jérôme; Vinatier, Claire

Year: 2023

Venue: Aging

DOI: https://doi.org/10.18632/aging.204881

Paper 3-Deazaadenosine keeps senescence at bay

Ana Guerrero; Jesús Gil · 2023 · Aging · DOI

Full title: 3-Deazaadenosine keeps senescence at bay

Authors: Ana Guerrero; Jesús Gil

Year: 2023

Venue: Aging

DOI: https://doi.org/10.18632/aging.204625

Paper A chronic wound model to investigate skin cellular senescence.

Wyles, Saranya P; Dashti, Parisa; Pirtskhalava, Tamar et al. · 2023 · Aging · DOI

Full title: A chronic wound model to investigate skin cellular senescence.

Authors: Wyles, Saranya P; Dashti, Parisa; Pirtskhalava, Tamar; Tekin, Burak; Inman, Christina; Gomez, Lilian Sales; Lagnado, Anthony B; Prata, Larissa; Jurk, Diana; Passos, João F; Tchkonia, Tamar; Kirkland, James L

Year: 2023

Venue: Aging

DOI: https://doi.org/10.18632/aging.204667

Paper Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema

Alberta Palazzo; Gabriela Makulyte; Delphine Goerhig et al. · 2023 · Aging · DOI

Full title: Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema

Authors: Alberta Palazzo; Gabriela Makulyte; Delphine Goerhig; Jean‐Jacques Médard; Vincent Gros; François Trottein; Serge Adnot; D. Vindrieux; J. Flaman; David Bernard

Year: 2023

Venue: Aging

DOI: https://doi.org/10.18632/aging.205259

Paper Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions

Lee, Edwin; Carreras-Gallo, Natàlia; Lopez, Leilani et al. · 2024 · Aging · DOI

Full title: Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions

Authors: Lee, Edwin; Carreras-Gallo, Natàlia; Lopez, Leilani; Turner, Logan; Lin, Aaron E.; Mendez, Tavis L.; Went, Hannah; Tomusiak, Alan; Verdin, Eric; Corley, Michael J.; Ndhlovu, Lishomwa C.; Smith, Ryan; Dwaraka, Varun B.

Year: 2024

Venue: Aging

DOI: https://doi.org/10.18632/aging.205581

Paper Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells

Joseph S. Spina; Tracy L. Carr; Lucy A. Phillips et al. · 2024 · Aging · DOI

Full title: Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells

Authors: Joseph S. Spina; Tracy L. Carr; Lucy A. Phillips; Heather L. Knight; Nancy E. Crosbie; Sarah M Lloyd; Manisha Jhala; Tony J. Lam; Jozsef Karman; M. Clements; Tovah A. Day; Justin D. Crane; William J. Housley

Year: 2024

Venue: Aging

DOI: https://doi.org/10.18632/aging.205994

Paper Senolytic agent ABT-263 mitigates low- and high-LET radiation-induced gastrointestinal cancer development in Apc1638N/+ mice

Kamendra Kumar; Bo-Hyun Moon; Santosh Kumar et al. · 2025 · Aging · DOI

Full title: Senolytic agent ABT-263 mitigates low- and high-LET radiation-induced gastrointestinal cancer development in Apc1638N/+ mice

Authors: Kamendra Kumar; Bo-Hyun Moon; Santosh Kumar; Jerry Angdisen; Bhaskar V S Kallakury; A. Fornace; S. Suman

Year: 2025

Venue: Aging

DOI: https://doi.org/10.18632/aging.206183

Paper Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1

Christelle Morris; Sébastien Durand; P. Jalinot · 2021 · OncoTarget · DOI

Full title: Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1

Authors: Christelle Morris; Sébastien Durand; P. Jalinot

Year: 2021

Venue: OncoTarget

DOI: https://doi.org/10.18632/oncotarget.27923

Paper Anti-aging: senolytics or gerostatics (unconventional view)

Blagosklonny, Mikhail V. · 2021 · Oncotarget · DOI

Full title: Anti-aging: senolytics or gerostatics (unconventional view)

Authors: Blagosklonny, Mikhail V.

Year: 2021

Venue: Oncotarget

DOI: https://doi.org/10.18632/oncotarget.28049

Paper Senescence-driven pathogenesis in chronic lung diseases: from mechanistic insights to translational approaches

Shaofei Liu; Si-Chang Fan; Rui-Qi Wang et al. · 2026 · Vessel Plus · DOI

Full title: Senescence-driven pathogenesis in chronic lung diseases: from mechanistic insights to translational approaches

Authors: Shaofei Liu; Si-Chang Fan; Rui-Qi Wang; Xiang-Jin Wang; Tian-Yang Lu; Jing-Wen Song; Yong-Jian Zhu; Zhifu Guo; Ni Zhu; Ping Yuan

Year: 2026

Venue: Vessel Plus

DOI: https://doi.org/10.20517/2574-1209.2025.115

Paper Senescent cell accumulation is associated with T-cell imbalance in the skin.

Matveeva, K S; Kolmykov, S K; Sokolova, T S et al. · 2025 · Vavilovskii zhurnal genetiki i selektsii · DOI

Full title: Senescent cell accumulation is associated with T-cell imbalance in the skin.

Authors: Matveeva, K S; Kolmykov, S K; Sokolova, T S; Salimov, D R; Shevyrev, D V

Year: 2025

Venue: Vavilovskii zhurnal genetiki i selektsii

DOI: https://doi.org/10.18699/vjgb-25-118

Paper Senolytic vaccination: a new mandate for cardiovascular health?

Lear, Travis; Finkel, Toren · 2022 · The Journal of Cardiovascular Aging · DOI

Full title: Senolytic vaccination: a new mandate for cardiovascular health?

Authors: Lear, Travis; Finkel, Toren

Year: 2022

Venue: The Journal of Cardiovascular Aging

DOI: https://doi.org/10.20517/jca.2022.03

Paper The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases

Salminen, Antero · 2024 · Journal of Molecular Medicine · DOI

Full title: The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases

Authors: Salminen, Antero

Year: 2024

Venue: Journal of Molecular Medicine

DOI: https://doi.org/10.1007/s00109-024-02444-6

Paper Senescence-associated β-galactosidase in subcutaneous adipose tissue associates with altered glycaemic status and truncal fat in severe obesity.

Rouault, Christine; Marcelin, Geneviève; Adriouch, Solia et al. · 2021 · Diabetologia · DOI

Full title: Senescence-associated β-galactosidase in subcutaneous adipose tissue associates with altered glycaemic status and truncal fat in severe obesity.

Authors: Rouault, Christine; Marcelin, Geneviève; Adriouch, Solia; Rose, Cindy; Genser, Laurent; Ambrosini, Marc; Bichet, Jean-Christophe; Zhang, Yanyan; Marquet, Florian; Aron-Wisnewsky, Judith; Poitou, Christine; André, Sébastien; Dérumeaux, Geneviève; Guerre-Millo, Michèle; Clément, Karine

Year: 2021

Venue: Diabetologia

DOI: https://doi.org/10.1007/s00125-020-05307-0

Paper Senescence under appraisal: hopes and challenges revisited

Davan-Wetton, Camilla S. A.; Pessolano, Emanuela; Perretti, Mauro et al. · 2021 · Cellular and Molecular Life Sciences · DOI

Full title: Senescence under appraisal: hopes and challenges revisited

Authors: Davan-Wetton, Camilla S. A.; Pessolano, Emanuela; Perretti, Mauro; Montero‐Melendez, Trinidad

Year: 2021

Venue: Cellular and Molecular Life Sciences

DOI: https://doi.org/10.1007/s00018-020-03746-x

Paper Cellular senescence: at the nexus between ageing and diabetes

Allyson K. Palmer; B. Gustafson; J. Kirkland et al. · 2019 · Diabetologia · DOI

Full title: Cellular senescence: at the nexus between ageing and diabetes

Authors: Allyson K. Palmer; B. Gustafson; J. Kirkland; U. Smith

Year: 2019

Venue: Diabetologia

DOI: https://doi.org/10.1007/s00125-019-4934-x

Paper Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard.

Rothmiller, Simone; Jäger, Niklas; Meier, Nicole et al. · 2021 · Archives of toxicology · DOI

Full title: Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard.

Authors: Rothmiller, Simone; Jäger, Niklas; Meier, Nicole; Meyer, Thimo; Neu, Adrian; Steinritz, Dirk; Thiermann, Horst; Scherer, Michael; Rummel, Christoph; Mangerich, Aswin; Bürkle, Alexander; Schmidt, Annette

Year: 2021

Venue: Archives of toxicology

DOI: https://doi.org/10.1007/s00204-020-02946-5

Paper Apoptosis resistance of senescent cells is an intrinsic barrier for senolysis induced by cardiac glycosides.

Deryabin, Pavel I; Shatrova, Alla N; Borodkina, Aleksandra V · 2021 · Cellular and molecular life sciences : CMLS · DOI

Full title: Apoptosis resistance of senescent cells is an intrinsic barrier for senolysis induced by cardiac glycosides.

Authors: Deryabin, Pavel I; Shatrova, Alla N; Borodkina, Aleksandra V

Year: 2021

Venue: Cellular and molecular life sciences : CMLS

DOI: https://doi.org/10.1007/s00018-021-03980-x

Paper Cellular senescence in the tumor with a bone niche microenvironment: friend or foe?

Alavimanesh, Sajad; Nayerain Jazi, Negar; Choubani, Maedeh et al. · 2025 · Clinical and experimental medicine · DOI

Full title: Cellular senescence in the tumor with a bone niche microenvironment: friend or foe?

Authors: Alavimanesh, Sajad; Nayerain Jazi, Negar; Choubani, Maedeh; Saeidi, Farzane; Afkhami, Hamed; Yarahmadi, Aref; Ronaghi, Hossein; Khani, Pouria; Modarressi, Mohammad Hossein

Year: 2025

Venue: Clinical and experimental medicine

DOI: https://doi.org/10.1007/s10238-025-01564-8

Paper Nano-encapsulated senolytic cocktail attenuates germ cell senescence in female mice.

Guan, Yiting; Deng, Shuyue; Zou, Xiaopeng et al. · 2025 · Cellular and molecular life sciences : CMLS · DOI

Full title: Nano-encapsulated senolytic cocktail attenuates germ cell senescence in female mice.

Authors: Guan, Yiting; Deng, Shuyue; Zou, Xiaopeng; Wei, Wenlu; Li, Zechen; Zhong, Jiajing; Zhu, Yanmei; Zhang, Donghui; Ju, Yanmin; Sun, Qing-Yuan; Zhang, Hongyong

Year: 2025

Venue: Cellular and molecular life sciences : CMLS

DOI: https://doi.org/10.1007/s00018-025-05697-7

Paper Repurposed FDA-approved drugs targeting genes influencing aging can extend lifespan and healthspan in rotifers

Snell, Terry W.; Johnston, Rachel; Matthews, Amelia B. et al. · 2018 · Biogerontology · DOI

Full title: Repurposed FDA-approved drugs targeting genes influencing aging can extend lifespan and healthspan in rotifers

Authors: Snell, Terry W.; Johnston, Rachel; Matthews, Amelia B.; Zhou, Hongyi; Gao, Mu; Skolnick, Jeffrey

Year: 2018

Venue: Biogerontology

DOI: https://doi.org/10.1007/s10522-018-9745-9

Paper Vascular senescence and aging: mechanisms, clinical implications, and therapeutic prospects.

Picos, Aitor; Seoane, Nuria; Campos-Toimil, Manuel et al. · 2025 · Biogerontology · DOI

Full title: Vascular senescence and aging: mechanisms, clinical implications, and therapeutic prospects.

Authors: Picos, Aitor; Seoane, Nuria; Campos-Toimil, Manuel; Viña, Dolores

Year: 2025

Venue: Biogerontology

DOI: https://doi.org/10.1007/s10522-025-10256-5

Paper Cellular Senescence Contributes to Colonic Barrier Integrity Impairment Induced by Toxoplasma gondii Infection

Yingting Huang; Yumeng Zhou; Zhicheng He et al. · 2025 · Inflammation · DOI

Full title: Cellular Senescence Contributes to Colonic Barrier Integrity Impairment Induced by Toxoplasma gondii Infection

Authors: Yingting Huang; Yumeng Zhou; Zhicheng He; Jiayi Yang; Jianqi Gu; Bingqian Cui; Siyu Li; Heng Deng; Wendi Zhao; Xiaoying Yang; Fenfen Sun; Cheng He; Wei Pan

Year: 2025

Venue: Inflammation

DOI: https://doi.org/10.1007/s10753-024-02213-0

Paper Therapeutic Potential of Senolytics in Cardiovascular Disease

Emily Dookun; J. Passos; H. Arthur et al. · 2020 · Cardiovascular Drugs and Therapy · DOI

Full title: Therapeutic Potential of Senolytics in Cardiovascular Disease

Authors: Emily Dookun; J. Passos; H. Arthur; G. Richardson

Year: 2020

Venue: Cardiovascular Drugs and Therapy

DOI: https://doi.org/10.1007/s10557-020-07075-w

Paper Hypoxia-inducible factor and cellular senescence in pulmonary aging and disease.

Thapa, Riya; Marianesan, Arockia Babu; Rekha, A et al. · 2025 · Biogerontology · DOI

Full title: Hypoxia-inducible factor and cellular senescence in pulmonary aging and disease.

Authors: Thapa, Riya; Marianesan, Arockia Babu; Rekha, A; Ganesan, Subbulakshmi; Kumari, Mukesh; Bhat, Asif Ahmad; Ali, Haider; Singh, Sachin Kumar; Chakraborty, Amlan; MacLoughlin, Ronan; Gupta, Gaurav; Dua, Kamal

Year: 2025

Venue: Biogerontology

DOI: https://doi.org/10.1007/s10522-025-10208-z

Paper Senolytic Treatment Attenuates Global Ischemic Brain Injury and Enhances Cognitive Recovery by Targeting Mitochondria

Caihong Gu; Ting Guo; Xiaobing Chen et al. · 2025 · Cellular and molecular neurobiology · DOI

Full title: Senolytic Treatment Attenuates Global Ischemic Brain Injury and Enhances Cognitive Recovery by Targeting Mitochondria

Authors: Caihong Gu; Ting Guo; Xiaobing Chen; Xinyu Zhou; Yong Sun

Year: 2025

Venue: Cellular and molecular neurobiology

DOI: https://doi.org/10.1007/s10571-025-01580-y

Paper Using the drug-protein interactome to identify anti-ageing compounds for humans

Fuentealba, Matías; Dönertaş, Handan Melike; Williams, Rhianna et al. · 2018 · DOI

Full title: Using the drug-protein interactome to identify anti-ageing compounds for humans

Authors: Fuentealba, Matías; Dönertaş, Handan Melike; Williams, Rhianna; Labbadia, Johnathan; Thornton, Janet M.; Partridge, Linda

Year: 2018

DOI: https://doi.org/10.1101/438234

Paper Senotherapeutic potential against xeroderma pigmentosum

Xuebing Wang; Masako Nishida; A. Yoshioka et al. · 2025 · bioRxiv · DOI

Full title: Senotherapeutic potential against xeroderma pigmentosum

Authors: Xuebing Wang; Masako Nishida; A. Yoshioka; C. Y. Chung; Shinya Hashimoto; Hideki Tanizawa; Shinya Ohta; Ken-ichi Noma; Takashi Fukumoto

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.05.22.655641

Paper Beyond Static Pipes: Mechanisms and In Vitro Models of Vascular Aging

Hetzer, Martin W.; Bersini, Simone · 2022 · Cold Spring Harbor Perspectives in Medicine · DOI

Full title: Beyond Static Pipes: Mechanisms and In Vitro Models of Vascular Aging

Authors: Hetzer, Martin W.; Bersini, Simone

Year: 2022

Venue: Cold Spring Harbor Perspectives in Medicine

DOI: https://doi.org/10.1101/cshperspect.a041180

Paper Senescence and the SASP: many therapeutic avenues

J. Birch; J. Gil · 2020 · Genes & Development · DOI

Full title: Senescence and the SASP: many therapeutic avenues

Authors: J. Birch; J. Gil

Year: 2020

Venue: Genes & Development

DOI: https://doi.org/10.1101/gad.343129.120

Paper Molecular Mechanisms of Cellular Senescence and Immuno-Senescence: Insights from Model Organisms and Emerging Pathways

Alebachew Molla · 2025 · American Journal of Biomedical and Life Sciences · DOI

Full title: Molecular Mechanisms of Cellular Senescence and Immuno-Senescence: Insights from Model Organisms and Emerging Pathways

Authors: Alebachew Molla

Year: 2025

Venue: American Journal of Biomedical and Life Sciences

DOI: https://doi.org/10.11648/j.ajbls.20251305.12

Paper Mitochondrial dysfunction in cell senescence and aging

Miwa, Satomi; Kashyap, Sonu; Chini, Eduardo N. et al. · 2022 · Journal of Clinical Investigation · DOI

Full title: Mitochondrial dysfunction in cell senescence and aging

Authors: Miwa, Satomi; Kashyap, Sonu; Chini, Eduardo N.; Zglinicki, Thomas von

Year: 2022

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci158447

Paper IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis.

Faust, Heather J; Zhang, Hong; Han, Jin et al. · 2020 · The Journal of clinical investigation · DOI

Full title: IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis.

Authors: Faust, Heather J; Zhang, Hong; Han, Jin; Wolf, Matthew T; Jeon, Ok Hee; Sadtler, Kaitlyn; Peña, Alexis N; Chung, Liam; Maestas, David R; Tam, Ada J; Pardoll, Drew M; Campisi, Judith; Housseau, Franck; Zhou, Daohong; Bingham, Clifton O; Elisseeff, Jennifer H

Year: 2020

Venue: The Journal of clinical investigation

DOI: https://doi.org/10.1172/JCI134091

Paper Aged murine bone marrow myeloid and mesenchymal cells develop unique senescence phenotypes.

Madison L. Doolittle; Mitchell N. Froemming; Jennifer L. Rowsey et al. · 2026 · Journal of Clinical Investigation · DOI

Full title: Aged murine bone marrow myeloid and mesenchymal cells develop unique senescence phenotypes.

Authors: Madison L. Doolittle; Mitchell N. Froemming; Jennifer L. Rowsey; Ming Ruan; Leena Sapra; J. Farr; David G Monroe; Sundeep Khosla

Year: 2026

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci195772

Paper Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice.

Liu, Jiatong; Zhang, Jun; Lin, Xi et al. · 2022 · The Journal of clinical investigation · DOI

Full title: Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice.

Authors: Liu, Jiatong; Zhang, Jun; Lin, Xi; Boyce, Brendan F; Zhang, Hengwei; Xing, Lianping

Year: 2022

Venue: The Journal of clinical investigation

DOI: https://doi.org/10.1172/JCI148073

Paper Cellular senescence: a key therapeutic target in aging and diseases

Lei Zhang; Louise E. Pitcher; Matthew J. Yousefzadeh et al. · 2022 · Journal of Clinical Investigation · DOI

Full title: Cellular senescence: a key therapeutic target in aging and diseases

Authors: Lei Zhang; Louise E. Pitcher; Matthew J. Yousefzadeh; L. Niedernhofer; P. Robbins; Yi Zhu

Year: 2022

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci158450

Paper Mixing old and young: enhancing rejuvenation and accelerating aging

Lau, Ashley; Kennedy, Brian K.; Kirkland, James L. et al. · 2019 · Journal of Clinical Investigation · DOI

Full title: Mixing old and young: enhancing rejuvenation and accelerating aging

Authors: Lau, Ashley; Kennedy, Brian K.; Kirkland, James L.; Tullius, Stefan G.

Year: 2019

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci123946

Paper JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice

Rivellini, Cristina; Porrello, Emanuela; Dina, Giorgia et al. · 2021 · Journal of Clinical Investigation · DOI

Full title: JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice

Authors: Rivellini, Cristina; Porrello, Emanuela; Dina, Giorgia; Mrakic-Sposta, Simona; Vezzoli, Alessandra; Bacigaluppi, Marco; Gullotta, Giorgia Serena; Chaabane, Linda; Leocani, Letizia; Marenna, Silvia; Colombo, Emanuela; Farina, Cinthia; Newcombe, Jia; Nave, Klaus-Armin; Pardi, Ruggero; Quattrini, Angelo; Previtali, Stefano C.

Year: 2021

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci145071

Paper Mechanisms and functions of cellular senescence.

Herranz, Nicolás; Gil, Jesús · 2018 · The Journal of clinical investigation · DOI

Full title: Mechanisms and functions of cellular senescence.

Authors: Herranz, Nicolás; Gil, Jesús

Year: 2018

Venue: The Journal of clinical investigation

DOI: https://doi.org/10.1172/JCI95148

Paper Senescent cells and osteoarthritis: a painful connection

Jeon, Ok Hee; David, Nathaniel E.; Campisi, Judith et al. · 2018 · Journal of Clinical Investigation · DOI

Full title: Senescent cells and osteoarthritis: a painful connection

Authors: Jeon, Ok Hee; David, Nathaniel E.; Campisi, Judith; Elisseeff, Jennifer H.

Year: 2018

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci95147

Paper An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis.

Lee, Jin Young; Reyes, Nabora S; Ravishankar, Supriya et al. · 2024 · The Journal of clinical investigation · DOI

Full title: An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis.

Authors: Lee, Jin Young; Reyes, Nabora S; Ravishankar, Supriya; Zhou, Minqi; Krasilnikov, Maria; Ringler, Christian; Pohan, Grace; Wilson, Chris; Ang, Kenny Kean-Hooi; Wolters, Paul J; Tsukui, Tatsuya; Sheppard, Dean; Arkin, Michelle R; Peng, Tien

Year: 2024

Venue: The Journal of clinical investigation

DOI: https://doi.org/10.1172/JCI173371

Paper Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

O’Sullivan, Eoin; Mylonas, Katie J.; Bell, Rachel et al. · 2022 · JCI Insight · DOI

Full title: Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

Authors: O’Sullivan, Eoin; Mylonas, Katie J.; Bell, Rachel; Carvalho, Cyril; Baird, David; Cairns, Carolynn; Gallagher, Kevin; Campbell, Ross; Docherty, Marie; Laird, Alexander; Henderson, Neil C.; Chandra, Tamir; Kirschner, Kristina; Conway, Bryan R.; Dihazi, Gry H.; Zeisberg, Michael; Hughes, Jeremy; Denby, Laura; Dihazi, Hassan; Ferenbach, David A.

Year: 2022

Venue: JCI Insight

DOI: https://doi.org/10.20944/preprints202207.0160.v1

Paper Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.

Ok-hee Jeon; David R. Wilson; Cristina C. Clement et al. · 2019 · JCI Insight · DOI

Full title: Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.

Authors: Ok-hee Jeon; David R. Wilson; Cristina C. Clement; Sona Rathod; Chris C. Cherry; B. Powell; Z. Lee; A. Khalil; J. Green; J. Campisi; L. Santambrogio; K. Witwer; J. Elisseeff

Year: 2019

Venue: JCI Insight

DOI: https://doi.org/10.1172/jci.insight.125019

Paper A single-cell mass cytometry platform to map the effects of preclinical drugs on cartilage homeostasis

Sahu, Neety; Grandi, Fiorella C.; Bhutani, Nidhi · 2022 · JCI Insight · DOI

Full title: A single-cell mass cytometry platform to map the effects of preclinical drugs on cartilage homeostasis

Authors: Sahu, Neety; Grandi, Fiorella C.; Bhutani, Nidhi

Year: 2022

Venue: JCI Insight

DOI: https://doi.org/10.1172/jci.insight.160702

Paper Senescence plays a role in myotonic dystrophy type 1.

García-Puga, Mikel; Saenz-Antoñanzas, Ander; Gerenu, Gorka et al. · 2022 · JCI insight · DOI

Full title: Senescence plays a role in myotonic dystrophy type 1.

Authors: García-Puga, Mikel; Saenz-Antoñanzas, Ander; Gerenu, Gorka; Arrieta-Legorburu, Alex; Fernández-Torrón, Roberto; Zulaica, Miren; Saenz, Amets; Elizazu, Joseba; Nogales-Gadea, Gisela; Gadalla, Shahinaz M; Araúzo-Bravo, Marcos J; López de Munain, Adolfo; Matheu, Ander

Year: 2022

Venue: JCI insight

DOI: https://doi.org/10.1172/jci.insight.159357

Paper Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia

Englund, Davis A.; Jolliffe, Alyssa M.; Hanson, Gabriel J. et al. · 2023 · JCI Insight · DOI

Full title: Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia

Authors: Englund, Davis A.; Jolliffe, Alyssa M.; Hanson, Gabriel J.; Aversa, Zaira; Zhang, Xu; Jiang, Xinyi; White, Thomas A.; Zhang, Lei; Monroe, David G.; Robbins, Paul D.; Niedernhofer, Laura J.; Kamenecka, Theodore M.; Khosla, Sundeep; LeBrasseur, Nathan K.

Year: 2023

Venue: JCI Insight

DOI: https://doi.org/10.1172/jci.insight.169512

Paper Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2

N. Cheng; Ki-Hyun Kim; L. Lau · 2022 · JCI Insight · DOI

Full title: Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2

Authors: N. Cheng; Ki-Hyun Kim; L. Lau

Year: 2022

Venue: JCI Insight

DOI: https://doi.org/10.1172/jci.insight.158207

Paper All-trans retinoic acid inhibits glioblastoma progression and attenuates radiation-induced brain injury

Minggang Fu; Yiling Zhang; Bi Peng et al. · 2024 · JCI Insight · DOI

Full title: All-trans retinoic acid inhibits glioblastoma progression and attenuates radiation-induced brain injury

Authors: Minggang Fu; Yiling Zhang; Bi Peng; Na Luo; Yuanyuan Zhang; Wenjun Zhu; Fen Yang; Ziqi Chen; Qiang Zhang; Qianxia Li; Xin Chen; Yuanhui Liu; Guoxian Long; Guangyuan Hu; Xiaohong Peng

Year: 2024

Venue: JCI Insight

DOI: https://doi.org/10.1172/jci.insight.179530

Paper Cytotoxic and senescence-inducing effects of BLU554 in pancreatic ductal adenocarcinoma: an in vitro study

Masakazu Fujiwara; Seiichi Shinji; Yuuki Shichi et al. · 2025 · BMC Cancer · DOI

Full title: Cytotoxic and senescence-inducing effects of BLU554 in pancreatic ductal adenocarcinoma: an in vitro study

Authors: Masakazu Fujiwara; Seiichi Shinji; Yuuki Shichi; K. Nonaka; Yasuko Hasegawa; Kimimasa Takahashi; Hirofumi Rokutan; Tomio Arai; Toshiyuki Ishiwata

Year: 2025

Venue: BMC Cancer

DOI: https://doi.org/10.1186/s12885-025-15317-z

Paper Dietary intervention reverses molecular markers of hepatocellular senescence in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH

Flensted-Jensen, Mathias; Oró, Denise; Rørbeck, Emma A. et al. · 2024 · BMC Gastroenterology · DOI

Full title: Dietary intervention reverses molecular markers of hepatocellular senescence in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH

Authors: Flensted-Jensen, Mathias; Oró, Denise; Rørbeck, Emma A.; Zhang, Chen; Madsen, Martin Rønn; Madsen, Andreas Nygaard; Norlin, Jenny; Feigh, Michael; Larsen, Steen; Hansen, Henrik H.

Year: 2024

Venue: BMC Gastroenterology

DOI: https://doi.org/10.1186/s12876-024-03141-x

Paper Geroprotector drugs and exercise: friends or foes on healthy longevity?

Elliehausen, Christian J.; Anderson, Rozalyn M.; Diffee, Gary M. et al. · 2023 · BMC Biology · DOI

Full title: Geroprotector drugs and exercise: friends or foes on healthy longevity?

Authors: Elliehausen, Christian J.; Anderson, Rozalyn M.; Diffee, Gary M.; Rhoads, Timothy W.; Lamming, Dudley W.; Hornberger, Troy A.; Konopka, Adam R.

Year: 2023

Venue: BMC Biology

DOI: https://doi.org/10.1186/s12915-023-01779-9

Paper Lycium barbarum polysaccharides in ageing and its potential use for prevention and treatment of osteoarthritis: a systematic review

Junguo Ni; M. Au; H. Kong et al. · 2021 · BMC Complementary Medicine and Therapies · DOI

Full title: Lycium barbarum polysaccharides in ageing and its potential use for prevention and treatment of osteoarthritis: a systematic review

Authors: Junguo Ni; M. Au; H. Kong; Xinluan Wang; C. Wen

Year: 2021

Venue: BMC Complementary Medicine and Therapies

DOI: https://doi.org/10.1186/s12906-021-03385-0

Paper Cellular senescence and SASP in tumor progression and therapeutic opportunities.

Dong, Zening; Luo, Yahan; Yuan, Zhangchen et al. · 2024 · Molecular cancer · DOI

Full title: Cellular senescence and SASP in tumor progression and therapeutic opportunities.

Authors: Dong, Zening; Luo, Yahan; Yuan, Zhangchen; Tian, Yu; Jin, Tianqiang; Xu, Feng

Year: 2024

Venue: Molecular cancer

DOI: https://doi.org/10.1186/s12943-024-02096-7

Paper Hemin enhances the cardioprotective effects of mesenchymal stem cell-derived exosomes against infarction via amelioration of cardiomyocyte senescence

Zheng, Huifeng; Liang, Xiaoting; Han, Qian et al. · 2021 · Journal of Nanobiotechnology · DOI

Full title: Hemin enhances the cardioprotective effects of mesenchymal stem cell-derived exosomes against infarction via amelioration of cardiomyocyte senescence

Authors: Zheng, Huifeng; Liang, Xiaoting; Han, Qian; Shao, Zhuang; Zhang, Yuxiao; Shi, Linli; Hong, Yimei; Li, Weifeng; Mai, Cong; Mo, Qingwen; Fu, Qing‐Ling; Ma, Xiaoxue; Lin, Fang; Li, Mimi; Hu, Bei; Li, Xin; Zhang, Yuelin

Year: 2021

Venue: Journal of Nanobiotechnology

DOI: https://doi.org/10.1186/s12951-021-01077-y

Paper Extracellular vesicles from ovarian cancer cells induce senescent lipid-laden macrophages to facilitate omental metastasis.

Li, Guoqing; Zhou, Xiaoling; Li, Wenhan et al. · 2025 · Journal of nanobiotechnology · DOI

Full title: Extracellular vesicles from ovarian cancer cells induce senescent lipid-laden macrophages to facilitate omental metastasis.

Authors: Li, Guoqing; Zhou, Xiaoling; Li, Wenhan; Wu, Qiulei; Liu, Tong; Huang, Lin; Liu, Xiaoli; Zhao, Jing; Xu, Xiaohan; Xu, Linjuan; Wang, Zehua; Gong, Lanqing; Cai, Liqiong; Cai, Jing

Year: 2025

Venue: Journal of nanobiotechnology

DOI: https://doi.org/10.1186/s12951-025-03612-7

Paper Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases

Zhou, Huakang; Khan, Dilaware; Hussain, Sajid Muhammad et al. · 2023 · Journal of Inflammation · DOI

Full title: Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases

Authors: Zhou, Huakang; Khan, Dilaware; Hussain, Sajid Muhammad; Gerdes, Norbert; Hagenbeck, Carsten; Rana, Majeed; Cornelius, Jan F.; Muhammad, Sajjad

Year: 2023

Venue: Journal of Inflammation

DOI: https://doi.org/10.1186/s12950-023-00366-7

Paper Ectopic and visceral fat deposition in aging, obesity, and idiopathic pulmonary fibrosis: an interconnected role

Cheng, Xiaoyun; Jiang, Shuhan; Pan, Boyu et al. · 2023 · Lipids in Health and Disease · DOI

Full title: Ectopic and visceral fat deposition in aging, obesity, and idiopathic pulmonary fibrosis: an interconnected role

Authors: Cheng, Xiaoyun; Jiang, Shuhan; Pan, Boyu; Xie, Wei; Meng, Jie

Year: 2023

Venue: Lipids in Health and Disease

DOI: https://doi.org/10.1186/s12944-023-01964-3

Paper Quercetin enhances decidualization through AKT-ERK-p53 signaling and supports a role for senescence in endometriosis.

Delenko, Julia; Xue, Xiangying; Chatterjee, Prodyot K et al. · 2024 · Reproductive biology and endocrinology : RB&E · DOI

Full title: Quercetin enhances decidualization through AKT-ERK-p53 signaling and supports a role for senescence in endometriosis.

Authors: Delenko, Julia; Xue, Xiangying; Chatterjee, Prodyot K; Hyman, Nathaniel; Shih, Andrew J; Adelson, Robert P; Safaric Tepes, Polona; Gregersen, Peter K; Metz, Christine N

Year: 2024

Venue: Reproductive biology and endocrinology : RB&E

DOI: https://doi.org/10.1186/s12958-024-01265-z

Paper Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin

Marco Raffaele; Kristína Kovačovicová; Jan Frohlich et al. · 2021 · Cell Communication and Signaling · DOI

Full title: Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin

Authors: Marco Raffaele; Kristína Kovačovicová; Jan Frohlich; Oriana Lo Re; S. Giallongo; J. Oben; M. Faldyna; L. Levá; A. Giannone; D. Cabibi; M. Vinciguerra

Year: 2021

Venue: Cell Communication and Signaling

DOI: https://doi.org/10.1186/s12964-021-00731-0

Paper Targeting cellular senescence in kidney diseases and aging: A focus on mesenchymal stem cells and their paracrine factors

Seyyedeh Mina Hejazian; Seyyed Sina Hejazian; Seyyedeh Mina Mostafavi et al. · 2024 · Cell Communication and Signaling · DOI

Full title: Targeting cellular senescence in kidney diseases and aging: A focus on mesenchymal stem cells and their paracrine factors

Authors: Seyyedeh Mina Hejazian; Seyyed Sina Hejazian; Seyyedeh Mina Mostafavi; Seyed Mahdi Hosseiniyan; S. Montazersaheb; M. Ardalan; S. Zununi Vahed; Abolfazl Barzegari

Year: 2024

Venue: Cell Communication and Signaling

DOI: https://doi.org/10.1186/s12964-024-01968-1

Paper Inhibition of the FEN1-PBX1 axis elicits cellular senescence in breast cancer via the increased intracellular reactive oxygen species levels.

Wu, Min; Wu, Benmeng; Huang, Xiaoshan et al. · 2025 · Journal of translational medicine · DOI

Full title: Inhibition of the FEN1-PBX1 axis elicits cellular senescence in breast cancer via the increased intracellular reactive oxygen species levels.

Authors: Wu, Min; Wu, Benmeng; Huang, Xiaoshan; Wang, Zirui; Zhu, Miaolin; Zhu, Yaqin; Yu, Lin; Liu, Jingjing

Year: 2025

Venue: Journal of translational medicine

DOI: https://doi.org/10.1186/s12967-025-06216-9

Paper Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study

Krishnakumar, I. M.; Jaja-Chimedza, Asha; Joseph, Ashil et al. · 2022 · Journal of Nutritional Science · DOI

Full title: Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study

Authors: Krishnakumar, I. M.; Jaja-Chimedza, Asha; Joseph, Ashil; Balakrishnan, Abhilash; Maliakel, Balu; Swick, Andrew G.

Year: 2022

Venue: Journal of Nutritional Science

DOI: https://doi.org/10.1017/jns.2022.72

Paper 68722 Role of ER calcium in beta cell senescence and diabetes pathophysiology

Staci A. Weaver; T. Kono; Farooq Syed et al. · 2021 · Journal of Clinical and Translational Science · DOI

Full title: 68722 Role of ER calcium in beta cell senescence and diabetes pathophysiology

Authors: Staci A. Weaver; T. Kono; Farooq Syed; R. Bone; C. Evans-Molina

Year: 2021

Venue: Journal of Clinical and Translational Science

DOI: https://doi.org/10.1017/cts.2021.446

Paper Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions

Yongsik Cho; Sumin Jeong; Hyeon-Seop Kim et al. · 2021 · Experimental and Molecular Medicine · DOI

Full title: Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions

Authors: Yongsik Cho; Sumin Jeong; Hyeon-Seop Kim; Donghyun Kang; Jeeyeon Lee; Seung-Baik Kang; Jin-Hong Kim

Year: 2021

Venue: Experimental and Molecular Medicine

DOI: https://doi.org/10.1038/s12276-021-00710-y

Paper Cellular senescence mediates fibrotic pulmonary disease

Schafer, Marissa J.; White, Thomas A.; Iijima, Koji et al. · 2017 · Nature Communications · DOI

Full title: Cellular senescence mediates fibrotic pulmonary disease

Authors: Schafer, Marissa J.; White, Thomas A.; Iijima, Koji; Haak, Andrew J.; Ligresti, Giovanni; Atkinson, Elizabeth J.; Oberg, Ann L.; Birch, Jodie; Salmonowicz, Hanna; Zhu, Yi; Mazula, Daniel L.; Brooks, Robert W.; Fuhrmann‐Stroissnigg, Heike; Pirtskhalava, Tamar; Prakash, Y. S.; Tchkonia, Tamar; Robbins, Paul D.; Aubry, Marie Christine; Passos, João F.; Kirkland, James L.; Tschumperlin, Daniel J.; Kita, Hirohito; LeBrasseur, Nathan K.

Year: 2017

Venue: Nature Communications

DOI: https://doi.org/10.1038/ncomms14532

Paper Cellular senescence drives age-dependent hepatic steatosis

Ogrodnik, Mikołaj; Miwa, Satomi; Tchkonia, Tamar et al. · 2017 · Nature Communications · DOI

Full title: Cellular senescence drives age-dependent hepatic steatosis

Authors: Ogrodnik, Mikołaj; Miwa, Satomi; Tchkonia, Tamar; Tiniakos, Dina; Wilson, Caroline; Lahat, Albert; Day, Christoper P.; Burt, Alastair D.; Palmer, Allyson K.; Anstee, Quentin M.; Grellscheid, Sushma Nagaraja; Hoeijmakers, Jan H.J.; Barnhoorn, Sander; Mann, Derek A.; Bird, Thomas G.; Vermeij, Wilbert P.; Kirkland, James L.; Passos, João F.; Zglinicki, Thomas von; Jurk, Diana

Year: 2017

Venue: Nature Communications

DOI: https://doi.org/10.1038/ncomms15691

Paper Lysosomal trapping of palbociclib and its functional implications.

Llanos, Susana; Megias, Diego; Blanco-Aparicio, Carmen et al. · 2019 · Oncogene · DOI

Full title: Lysosomal trapping of palbociclib and its functional implications.

Authors: Llanos, Susana; Megias, Diego; Blanco-Aparicio, Carmen; Hernández-Encinas, Elena; Rovira, Miguel; Pietrocola, Federico; Serrano, Manuel

Year: 2019

Venue: Oncogene

DOI: https://doi.org/10.1038/s41388-019-0695-8

Paper SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence.

Lee, Sang Hyup; Yang, Ji-Hye; Park, Ui-Hyun et al. · 2023 · Experimental & molecular medicine · DOI

Full title: SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence.

Authors: Lee, Sang Hyup; Yang, Ji-Hye; Park, Ui-Hyun; Choi, Hanbyeul; Kim, Yoo Sung; Yoon, Bo-Eun; Han, Hye-Jeong; Kim, Hyun-Taek; Um, Soo-Jong; Kim, Eun-Joo

Year: 2023

Venue: Experimental & molecular medicine

DOI: https://doi.org/10.1038/s12276-023-01012-1

Paper MEOX1: a novel druggable target that orchestrates the activation of fibroblasts in cardiac fibrosis

David Schumacher; Fabian Peisker; R. Kramann · 2021 · Signal Transduction and Targeted Therapy · DOI

Full title: MEOX1: a novel druggable target that orchestrates the activation of fibroblasts in cardiac fibrosis

Authors: David Schumacher; Fabian Peisker; R. Kramann

Year: 2021

Venue: Signal Transduction and Targeted Therapy

DOI: https://doi.org/10.1038/s41392-021-00842-7

Paper Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema.

Park, Jung-Jin; Oh, Kwangseok; Lee, Gun-Wu et al. · 2023 · Experimental & molecular medicine · DOI

Full title: Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema.

Authors: Park, Jung-Jin; Oh, Kwangseok; Lee, Gun-Wu; Bang, Geul; Park, Jin-Hee; Kim, Han-Byeol; Kim, Jin Young; Shin, Eun-Young; Kim, Eung-Gook

Year: 2023

Venue: Experimental & molecular medicine

DOI: https://doi.org/10.1038/s12276-023-00966-6

Paper BET family protein degraders poised to join the senolytic arsenal

Zufeng Guo; Hanjing Peng; Yongmei Xie · 2020 · Signal Transduction and Targeted Therapy · DOI

Full title: BET family protein degraders poised to join the senolytic arsenal

Authors: Zufeng Guo; Hanjing Peng; Yongmei Xie

Year: 2020

Venue: Signal Transduction and Targeted Therapy

DOI: https://doi.org/10.1038/s41392-020-0202-2

Paper Step further towards targeted senolytic therapy: therapeutic potential of uPAR-CAR T cells for senescence-related diseases

Yujia Huang; Tao Liu · 2020 · Signal Transduction and Targeted Therapy · DOI

Full title: Step further towards targeted senolytic therapy: therapeutic potential of uPAR-CAR T cells for senescence-related diseases

Authors: Yujia Huang; Tao Liu

Year: 2020

Venue: Signal Transduction and Targeted Therapy

DOI: https://doi.org/10.1038/s41392-020-00268-7

Paper Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma models.

Sigaud, Romain; Stefanski, Anja; Selt, Florian et al. · 2025 · Signal transduction and targeted therapy · DOI

Full title: Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma models.

Authors: Sigaud, Romain; Stefanski, Anja; Selt, Florian; Kocher, Daniela; Usta, Diren; Picard, Daniel; Büdenbender, Isabel; Remke, Marc; Pfister, Stefan M; Jones, David T W; Brummer, Tilman; Witt, Olaf; Milde, Till

Year: 2025

Venue: Signal transduction and targeted therapy

DOI: https://doi.org/10.1038/s41392-025-02279-8

Paper Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults

Diniz, Breno S.; Reynolds, Charles F.; Sibille, Etienne et al. · 2019 · Translational Psychiatry · DOI

Full title: Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults

Authors: Diniz, Breno S.; Reynolds, Charles F.; Sibille, Etienne; Bot, Mariska; Penninx, Brenda W.J.H.

Year: 2019

Venue: Translational Psychiatry

DOI: https://doi.org/10.1038/s41398-019-0541-3

Paper Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

Hubáčková, Soňa; Davidová, Eliška; Rohlenová, Kateřina et al. · 2018 · Cell Death and Differentiation · DOI

Full title: Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

Authors: Hubáčková, Soňa; Davidová, Eliška; Rohlenová, Kateřina; Štursa, Jan; Werner, Lukáš; Anděra, Ladislav; Dong, Lan‐Feng; Terp, Mikkel G.; Hodný, Zdeněk; Ditzel, Henrik J.; Rohlena, Jakub; Neužil, Jiřı́

Year: 2018

Venue: Cell Death and Differentiation

DOI: https://doi.org/10.1038/s41418-018-0118-3

Paper Paracrine roles of cellular senescence in promoting tumourigenesis.

Gonzalez-Meljem, Jose Mario; Apps, John Richard; Fraser, Helen Christina et al. · 2018 · British journal of cancer · DOI

Full title: Paracrine roles of cellular senescence in promoting tumourigenesis.

Authors: Gonzalez-Meljem, Jose Mario; Apps, John Richard; Fraser, Helen Christina; Martinez-Barbera, Juan Pedro

Year: 2018

Venue: British journal of cancer

DOI: https://doi.org/10.1038/s41416-018-0066-1

Paper Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair.

Li, Chengjun; Qin, Tian; Zhao, Jinyun et al. · 2024 · Bone research · DOI

Full title: Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair.

Authors: Li, Chengjun; Qin, Tian; Zhao, Jinyun; Jin, Yuxin; Qin, Yiming; He, Rundong; Wu, Tianding; Duan, Chunyue; Jiang, Liyuan; Yuan, Feifei; Lu, Hongbin; Cao, Yong; Hu, Jianzhong

Year: 2024

Venue: Bone research

DOI: https://doi.org/10.1038/s41413-024-00323-x

Paper Combining adoptive NK cell infusion with a dopamine-releasing peptide reduces senescent cells in aged mice

Zongke Bai; Peiwei Yang; F. Yu et al. · 2022 · Cell Death and Disease · DOI

Full title: Combining adoptive NK cell infusion with a dopamine-releasing peptide reduces senescent cells in aged mice

Authors: Zongke Bai; Peiwei Yang; F. Yu; Zhong Li; Zheng Yao; Jean Martinez; Mengwei Li; Hanmei Xu

Year: 2022

Venue: Cell Death and Disease

DOI: https://doi.org/10.1038/s41419-022-04562-w

Paper Induction of senescence-associated secretory phenotype underlies the therapeutic efficacy of PRC2 inhibition in cancer

Chu, Liping; Qu, Yu-Xiu; An, Yang et al. · 2022 · Cell Death and Disease · DOI

Full title: Induction of senescence-associated secretory phenotype underlies the therapeutic efficacy of PRC2 inhibition in cancer

Authors: Chu, Liping; Qu, Yu-Xiu; An, Yang; Hou, Linjun; Li, Juewan; Li, Weijia; Fan, Gaofeng; Song, Bao‐Liang; Li, En; Zhang, Liye; Qi, Wei

Year: 2022

Venue: Cell Death and Disease

DOI: https://doi.org/10.1038/s41419-022-04601-6

Paper Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides

Trayssac, Magali; Clarke, Christopher J.; Stith, Jeffrey L. et al. · 2021 · Cell Death and Disease · DOI

Full title: Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides

Authors: Trayssac, Magali; Clarke, Christopher J.; Stith, Jeffrey L.; Snider, Justin M.; Newen, Naomi; Gault, Christopher; Hannun, Yusuf A.; Obeid, Lina M.

Year: 2021

Venue: Cell Death and Disease

DOI: https://doi.org/10.1038/s41419-020-03281-4

Paper Early senescence and production of senescence-associated cytokines are major determinants of radioresistance in head-and-neck squamous cell carcinoma

Schoetz, Ulrike; Klein, Diana; Heß, Julia et al. · 2021 · Cell Death and Disease · DOI

Full title: Early senescence and production of senescence-associated cytokines are major determinants of radioresistance in head-and-neck squamous cell carcinoma

Authors: Schoetz, Ulrike; Klein, Diana; Heß, Julia; Shnayien, Seyd; Spoerl, Steffen; Orth, Michael; Mutlu, Samet; Hennel, Roman; Sieber, Anja; Ganswindt, Ute; Luka, Benedikt; Thomsen, Andreas; Unger, Kristian; Jendrossek, Verena; Zitzelsberger, Horst; Blüthgen, Nils; Belka, Claus; Unkel, Steffen; Klinger, Bertram; Lauber, Kirsten

Year: 2021

Venue: Cell Death and Disease

DOI: https://doi.org/10.1038/s41419-021-04454-5

Paper Sequential targeting of YAP1 and p21 enhances the elimination of senescent cells induced by the BET inhibitor JQ1

Zhang, Huan‐Tian; Gui, Tao; Liu, Rixu et al. · 2021 · Cell Death and Disease · DOI

Full title: Sequential targeting of YAP1 and p21 enhances the elimination of senescent cells induced by the BET inhibitor JQ1

Authors: Zhang, Huan‐Tian; Gui, Tao; Liu, Rixu; Tong, Kui‐Leung; Wu, Chongjie; Li, Zhenyan; Huang, Xun; Xu, Qiutong; Yang, Jie; Tang, Wang; Sang, Yuan; Liu, Wanting; Liu, Ning; Ross, Ryan D.; He, Qing‐Yu; Zha, Zhengang

Year: 2021

Venue: Cell Death and Disease

DOI: https://doi.org/10.1038/s41419-021-03416-1

Paper Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma

Hu, Qinchao; Peng, Jianmin; Jiang, Laibo et al. · 2020 · Cell Death and Disease · DOI

Full title: Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma

Authors: Hu, Qinchao; Peng, Jianmin; Jiang, Laibo; Li, Wuguo; Su, Qiao; Zhang, Jiayu; Li, Huan; Song, Ming; Cheng, Bin; Xia, Juan; Wu, Tong

Year: 2020

Venue: Cell Death and Disease

DOI: https://doi.org/10.1038/s41419-020-03126-0

Paper Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche.

Peng, Xiaohong; Wu, Yi; Brouwer, Uilke et al. · 2020 · Cell death & disease · DOI

Full title: Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche.

Authors: Peng, Xiaohong; Wu, Yi; Brouwer, Uilke; van Vliet, Thijmen; Wang, Boshi; Demaria, Marco; Barazzuol, Lara; Coppes, Rob P

Year: 2020

Venue: Cell death & disease

DOI: https://doi.org/10.1038/s41419-020-03074-9

Paper p16-mediated G0/G1 cell cycle arrest leads to SASP and fibrosis in Fuchs endothelial corneal dystrophy

Mohit Parekh; Yadav Adhikari; Neha Deshpande et al. · 2026 · Cell Death and Disease · DOI

Full title: p16-mediated G0/G1 cell cycle arrest leads to SASP and fibrosis in Fuchs endothelial corneal dystrophy

Authors: Mohit Parekh; Yadav Adhikari; Neha Deshpande; R. Wong; M. Price; Francis W. Price; Ula V. Jurkunas

Year: 2026

Venue: Cell Death and Disease

DOI: https://doi.org/10.1038/s41419-026-08425-6

Paper Targeting CK2 eliminates senescent cells and prolongs lifespan in Zmpste24-deficient mice.

Zhang, Jie; Sun, Pengfei; Wu, Zhuping et al. · 2024 · Cell death & disease · DOI

Full title: Targeting CK2 eliminates senescent cells and prolongs lifespan in Zmpste24-deficient mice.

Authors: Zhang, Jie; Sun, Pengfei; Wu, Zhuping; Wu, Jie; Jia, Jiali; Zou, Haoman; Mo, Yanzhen; Zhou, Zhongjun; Liu, Baohua; Ao, Ying; Wang, Zimei

Year: 2024

Venue: Cell death & disease

DOI: https://doi.org/10.1038/s41419-024-06760-0

Paper Nintedanib induces senolytic effect via STAT3 inhibition.

Cho, Hyun-Ji; Hwang, Jeong-A; Yang, Eun Jae et al. · 2022 · Cell death & disease · DOI

Full title: Nintedanib induces senolytic effect via STAT3 inhibition.

Authors: Cho, Hyun-Ji; Hwang, Jeong-A; Yang, Eun Jae; Kim, Eok-Cheon; Kim, Jae-Ryong; Kim, Sung Young; Kim, Young Zoon; Park, Sang Chul; Lee, Young-Sam

Year: 2022

Venue: Cell death & disease

DOI: https://doi.org/10.1038/s41419-022-05207-8

Paper Ionizing irradiation-induced Fgr in senescent cells mediates fibrosis

Mukherjee, Amitava; Epperly, Michael W.; Shields, Donna et al. · 2021 · Cell Death Discovery · DOI

Full title: Ionizing irradiation-induced Fgr in senescent cells mediates fibrosis

Authors: Mukherjee, Amitava; Epperly, Michael W.; Shields, Donna; Hou, Wen‐Chi; Fisher, Renee; Hamade, D.F.; Wang, Hong; Huq, M. Saiful; Bao, Riyue; Tabib, Tracy; Monier, Daisy; Watkins, Simon C.; Calderon, Michael; Greenberger, Joel S.

Year: 2021

Venue: Cell Death Discovery

DOI: https://doi.org/10.1038/s41420-021-00741-4

Paper Cellular senescence in ischemia/reperfusion injury

Chen, Chaojin; Zheng, Muxu; Hou, Hongbiao et al. · 2022 · Cell Death Discovery · DOI

Full title: Cellular senescence in ischemia/reperfusion injury

Authors: Chen, Chaojin; Zheng, Muxu; Hou, Hongbiao; Fang, Sijian; Chen, Liubing; Yang, Jing; Yao, Weifeng; Zhang, Qi; Hei, Ziqing

Year: 2022

Venue: Cell Death Discovery

DOI: https://doi.org/10.1038/s41420-022-01205-z

Paper Inhibition of MCL-1 to eliminate senescent cells and mitigate renal fibrosis in aristolochic acid nephropathy.

Gao, Peng; Cenatus, Schrodinger; Henley, Nathalie et al. · 2025 · Cell death & disease · DOI

Full title: Inhibition of MCL-1 to eliminate senescent cells and mitigate renal fibrosis in aristolochic acid nephropathy.

Authors: Gao, Peng; Cenatus, Schrodinger; Henley, Nathalie; Pichette, Vincent; Mallette, Frédérick A; Barrera-Chimal, Jonatan; Gerarduzzi, Casimiro

Year: 2025

Venue: Cell death & disease

DOI: https://doi.org/10.1038/s41419-025-08268-7

Paper Radiation-induced liver injury and hepatocyte senescence

Zhu, Wei; Zhang, Xiaofen; Yu, Mengli et al. · 2021 · Cell Death Discovery · DOI

Full title: Radiation-induced liver injury and hepatocyte senescence

Authors: Zhu, Wei; Zhang, Xiaofen; Yu, Mengli; Lin, Bingru; Yu, Chaohui

Year: 2021

Venue: Cell Death Discovery

DOI: https://doi.org/10.1038/s41420-021-00634-6

Paper Abl depletion via autophagy mediates the beneficial effects of quercetin against Alzheimer pathology across species

Schiavi, Alfonso; Cirotti, Claudia; Gerber, Lora‐Sophie et al. · 2023 · Cell Death Discovery · DOI

Full title: Abl depletion via autophagy mediates the beneficial effects of quercetin against Alzheimer pathology across species

Authors: Schiavi, Alfonso; Cirotti, Claudia; Gerber, Lora‐Sophie; Lauro, Giulia Di; Maglioni, Silvia; Shibao, Priscila Yumi Tanaka; Montresor, Sabrina; Kirstein, Janine; Petzsch, Patrick; Köhrer, Karl; Schins, Roel P. F.; Wahle, Tina; Barilá, Daniela; Ventura, Natascia

Year: 2023

Venue: Cell Death Discovery

DOI: https://doi.org/10.1038/s41420-023-01592-x

Paper High content-imaging drug synergy screening identifies specific senescence-related vulnerabilities of mesenchymal neuroblastomas

Sonja Herter; Marta Emperador; Kyriaki Smyrilli et al. · 2025 · Cell Death and Disease · DOI

Full title: High content-imaging drug synergy screening identifies specific senescence-related vulnerabilities of mesenchymal neuroblastomas

Authors: Sonja Herter; Marta Emperador; Kyriaki Smyrilli; Daniela Kocher; Simay Celikyürekli; Constantia Zeiser; Xenia F. Gerloff; Sina Kreth; K. Henrich; K. Maass; Johanna Rettenmeier; T. Grünewald; H. Peterziel; Frank Westermann; A. Hamacher-Brady; Olaf Witt; Ina Oehme

Year: 2025

Venue: Cell Death and Disease

DOI: https://doi.org/10.1038/s41419-025-07933-1

Paper Healthy aging—would cytotoxic T lymphocytes stand out?

Tianyu Zhang; Jinjin Zhang; Shixuan Wang · 2023 · Cell Death Discovery · DOI

Full title: Healthy aging—would cytotoxic T lymphocytes stand out?

Authors: Tianyu Zhang; Jinjin Zhang; Shixuan Wang

Year: 2023

Venue: Cell Death Discovery

DOI: https://doi.org/10.1038/s41420-023-01699-1

Paper Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

Montero‐Melendez, Trinidad; Nagano, A.; Chelala, Claude et al. · 2020 · Nature Communications · DOI

Full title: Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

Authors: Montero‐Melendez, Trinidad; Nagano, A.; Chelala, Claude; Filer, Andrew; Buckley, Christopher D.; Perretti, Mauro

Year: 2020

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-020-14421-x

Paper Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

Cai, Yusheng; Zhou, Huanhuan; Zhu, Yinhua et al. · 2020 · Cell Research · DOI

Full title: Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

Authors: Cai, Yusheng; Zhou, Huanhuan; Zhu, Yinhua; Sun, Qi; Ji, Yin; Xue, Anqi; Wang, Yuting; Chen, Wenhan; Yu, Xiaojie; Wang, Longteng; Chen, Han; Li, Cheng; Luo, Tuoping; Deng, Hongkui

Year: 2020

Venue: Cell Research

DOI: https://doi.org/10.1038/s41422-020-0314-9

Paper Aging skin and non-surgical procedures: a basic science overview

Vandiver, Amy R.; Hogan, Sara · 2020 · Plastic and Aesthetic Research · DOI

Full title: Aging skin and non-surgical procedures: a basic science overview

Authors: Vandiver, Amy R.; Hogan, Sara

Year: 2020

Venue: Plastic and Aesthetic Research

DOI: https://doi.org/10.20517/2347-9264.2020.159

Paper Cardiomyocyte senescence and the potential therapeutic role of senolytics in the heart.

Zhai, Peiyong; Sadoshima, Junichi · 2024 · The journal of cardiovascular aging · DOI

Full title: Cardiomyocyte senescence and the potential therapeutic role of senolytics in the heart.

Authors: Zhai, Peiyong; Sadoshima, Junichi

Year: 2024

Venue: The journal of cardiovascular aging

DOI: https://doi.org/10.20517/jca.2024.06

Paper - **Authors:** Madonna, Rosalinda - **Year:** 2022 - **Journal:** The Journal of Cardiovascular Aging - **Source:** openalex

Madonna, Rosalinda · 2022 · The Journal of Cardiovascular Aging · DOI

Full title: - **Authors:** Madonna, Rosalinda - **Year:** 2022 - **Journal:** The Journal of Cardiovascular Aging - **Source:** openalex

Authors: Madonna, Rosalinda

Year: 2022

Venue: The Journal of Cardiovascular Aging

DOI: https://doi.org/10.20517/jca.2021.34

Paper Therapeutic potential of flavonoids used in traditional Chinese medicine – a comparative study of galangin, kaempferol, chrysin and fisetin

Sokal, Arkadiusz; Stocerz, Klaudia; Olczyk, Paweł et al. · 2024 · Annales Academiae Medicae Silesiensis · DOI

Full title: Therapeutic potential of flavonoids used in traditional Chinese medicine – a comparative study of galangin, kaempferol, chrysin and fisetin

Authors: Sokal, Arkadiusz; Stocerz, Klaudia; Olczyk, Paweł; Kadela-Tomanek, Monika

Year: 2024

Venue: Annales Academiae Medicae Silesiensis

DOI: https://doi.org/10.18794/aams/175007

Paper Immune mechanisms of cardiac aging

Goldstein, Daniel R.; Abdel‐Latif, Ahmed · 2023 · The Journal of Cardiovascular Aging · DOI

Full title: Immune mechanisms of cardiac aging

Authors: Goldstein, Daniel R.; Abdel‐Latif, Ahmed

Year: 2023

Venue: The Journal of Cardiovascular Aging

DOI: https://doi.org/10.20517/jca.2023.02

Paper New therapies targeting aging cells in the skin

Anna Paszel-Jaworska; Justyna Gornowicz-Porowska; A. Dańczak‑Pazdrowska et al. · 2023 · Journal of Medical Sciences · DOI

Full title: New therapies targeting aging cells in the skin

Authors: Anna Paszel-Jaworska; Justyna Gornowicz-Porowska; A. Dańczak‑Pazdrowska; A. Polańska; V. Krajka-Kuźniak; M. Stawny; Aleksandra Gostyńska; Michal M. Masternak; B. Rubiś

Year: 2023

Venue: Journal of Medical Sciences

DOI: https://doi.org/10.20883/medical.e903

Paper Targeting vascular senescence in cardiovascular disease with aging.

Hall, Shelby A; Lesniewski, Lisa A · 2024 · The journal of cardiovascular aging · DOI

Full title: Targeting vascular senescence in cardiovascular disease with aging.

Authors: Hall, Shelby A; Lesniewski, Lisa A

Year: 2024

Venue: The journal of cardiovascular aging

DOI: https://doi.org/10.20517/jca.2023.45

Paper Tissue-Specific Landscape of Metabolic Dysregulation during Ageing

Zhang, Fangrong; Kerbl-Knapp, Jakob; Akhmetshina, Alena et al. · 2021 · Biomolecules · DOI

Full title: Tissue-Specific Landscape of Metabolic Dysregulation during Ageing

Authors: Zhang, Fangrong; Kerbl-Knapp, Jakob; Akhmetshina, Alena; Korbelius, Melanie; Kuentzel, Katharina B.; Vujić, Nemanja; Hörl, Gerd; Paar, Margret; Kratky, Dagmar; Steyrer, Ernst; Madl, Tobias

Year: 2021

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom11020235

Paper Cellular Senescence: Pathogenic Mechanisms in Lung Fibrosis

Parimon, Tanyalak; Hohmann, M.; Yao, Changfu · 2021 · International Journal of Molecular Sciences · DOI

Full title: Cellular Senescence: Pathogenic Mechanisms in Lung Fibrosis

Authors: Parimon, Tanyalak; Hohmann, M.; Yao, Changfu

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms22126214

Paper Extracellular vesicles: the key to unlocking mechanisms of age-related vascular disease?

Whitehead, Meredith; Antonazzi, Marco; Shanahan, Catherine M. · 2024 · The Journal of Cardiovascular Aging · DOI

Full title: Extracellular vesicles: the key to unlocking mechanisms of age-related vascular disease?

Authors: Whitehead, Meredith; Antonazzi, Marco; Shanahan, Catherine M.

Year: 2024

Venue: The Journal of Cardiovascular Aging

DOI: https://doi.org/10.20517/jca.2023.49

Paper Senescent cells as new pharmacological targets for age-related diseases and anti-aging therapy

Michal M. Masternak · 2023 · Journal of Medical Sciences · DOI

Full title: Senescent cells as new pharmacological targets for age-related diseases and anti-aging therapy

Authors: Michal M. Masternak

Year: 2023

Venue: Journal of Medical Sciences

DOI: https://doi.org/10.20883/medical.e907

Paper NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Lee, Patricia; Blood, Philip D.; Börner, Katy et al. · 2022 · Preprints.org · DOI

Full title: NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Authors: Lee, Patricia; Blood, Philip D.; Börner, Katy; Campisi, Judith; Chen, Feng; Daldrup‐Link, Heike E.; Jager, Phil De; Ding, Li; Duncan, Francesca E.; Eickelberg, Oliver; Fan, Rong; Finkel, Toren; Garovic, Vesna D.; Gehlenborg, Nils; Glass, Carolyn; Bar‐Joseph, Ziv; Katiyar, Pragati; Kim, Sojin; Königshoff, Mélanie; Kuchel, George A.; Lee, Haesung; Lee, Jun Hee; Ma, Jian; Ma, Qin; Melov, Simon; Metis, Kay; Mora, Ana L.; Musi, Nicolas; Neretti, Nicola; Passos, João F.; Rahman, Irfan; Rivera‐Mulia, Juan Carlos; Robson, Paul; Rojas, Mauricio; Roy, Ananda L.; Schilling, Birgit; Shi, Pixu; Silverstein, Jonathan C.; Suryadevera, Vidyani; Xie, Jichun; Wang, Jinhua; Wong, An-Kwok Ian; Niedernhofer, Laura J.

Year: 2022

Venue: Preprints.org

Paper YAP/TAZ dull the STING of aging

J. Francisco; Dominic P Del Re · 2022 · The Journal of Cardiovascular Aging · DOI

Full title: YAP/TAZ dull the STING of aging

Authors: J. Francisco; Dominic P Del Re

Year: 2022

Venue: The Journal of Cardiovascular Aging

DOI: https://doi.org/10.20517/jca.2022.33

Paper Epigenetic dysregulation in cardiovascular aging and disease

Herman, Allison B.; Occean, James R.; Sen, Payel · 2021 · The Journal of Cardiovascular Aging · DOI

Full title: Epigenetic dysregulation in cardiovascular aging and disease

Authors: Herman, Allison B.; Occean, James R.; Sen, Payel

Year: 2021

Venue: The Journal of Cardiovascular Aging

DOI: https://doi.org/10.20517/jca.2021.16

Paper Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan.

Sharma, Arastu; Chabloz, Sophie; Lapides, Rebecca A et al. · 2023 · Nutrients · DOI

Full title: Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan.

Authors: Sharma, Arastu; Chabloz, Sophie; Lapides, Rebecca A; Roider, Elisabeth; Ewald, Collin Y

Year: 2023

Venue: Nutrients

DOI: https://doi.org/10.3390/nu15020445

Paper Skeletal Aging and Osteoporosis: Cellular Senescence and Beyond

Chandra, Abhishek; Rajawat, Jyotika · 2021 · Preprints.org · DOI

Full title: Skeletal Aging and Osteoporosis: Cellular Senescence and Beyond

Authors: Chandra, Abhishek; Rajawat, Jyotika

Year: 2021

Venue: Preprints.org

DOI: https://doi.org/10.20944/preprints202102.0127.v1

Paper Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-Aging Strategies

Kitaeva, Kristina V.; Solovyeva, Valeriya V.; Blatt, Nataliya L. et al. · 2024 · International Journal of Molecular Sciences · DOI

Full title: Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-Aging Strategies

Authors: Kitaeva, Kristina V.; Solovyeva, Valeriya V.; Blatt, Nataliya L.; Rizvanov, Albert A.

Year: 2024

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms25010643

Paper A BDNF-TrkB autocrine loop enhances senescent cell viability

Anerillas, Carlos; Herman, Allison B.; Munk, Rachel et al. · 2022 · Nature Communications · DOI

Full title: A BDNF-TrkB autocrine loop enhances senescent cell viability

Authors: Anerillas, Carlos; Herman, Allison B.; Munk, Rachel; Garrido, Amanda; Lam, Kwan-Wood Gabriel; Payea, Matthew J.; Rossi, Martina; Tsitsipatis, Dimitrios; Martindale, Jennifer L.; Piao, Yulan; Mazan-Mamczarz, Krystyna; Fan, Jinshui; Cui, Chang‐Yi; De, Supriyo; Abdelmohsen, Kotb; Cabo, Rafael de; Gorospe, Myriam

Year: 2022

Venue: Nature Communications

DOI: https://doi.org/10.20944/preprints202403.1692.v1

Paper The Future of Antipsychotic Interventions: From Managing Symptoms to Improving Outcomes

Sfera, Adonis; Imran, Hassan; Sfera, Dan O et al. · 2024 · Preprints.org · DOI

Full title: The Future of Antipsychotic Interventions: From Managing Symptoms to Improving Outcomes

Authors: Sfera, Adonis; Imran, Hassan; Sfera, Dan O; Anton, Jacob; Kozlakidis, Zisis; Hazan, Sabine

Year: 2024

Venue: Preprints.org

Paper Comparative Study of a Potent CNS-Permeable RARβ-Modulator, Ellorarxine, in Neuronal Cells In Vitro

Zhang, Yunxi; Gailloud, Lilie; Pinckney, Rosella et al. · 2024 · Preprints.org · DOI

Full title: Comparative Study of a Potent CNS-Permeable RARβ-Modulator, Ellorarxine, in Neuronal Cells In Vitro

Authors: Zhang, Yunxi; Gailloud, Lilie; Pinckney, Rosella; Whiting, Andrew; Chazot, Paul L.

Year: 2024

Venue: Preprints.org

DOI: https://doi.org/10.20944/preprints202403.0468.v1

Paper Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

Corina Amor; Inés Fernández-Maestre; Saria Chowdhury et al. · 2024 · Nature Aging · DOI

Full title: Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

Authors: Corina Amor; Inés Fernández-Maestre; Saria Chowdhury; Yu-jui Ho; Sandeep Nadella; Courtenay Graham; Sebastian E. Carrasco; Emmanuella Nnuji-John; Judith Feucht; Clemens Hinterleitner; Valentin J A Barthet; Jacob A. Boyer; Riccardo Mezzadra; Matthew Wereski; D. Tuveson; Ross L. Levine; Lee W Jones; Michel Sadelain; Scott W. Lowe

Year: 2024

Venue: Nature Aging

DOI: https://doi.org/10.26420/physmedrehabilint.2024.1245

Paper Cellular Senescence and Anti-Aging Strategies in Aesthetic Medicine: A Bibliometric Analysis and Brief Review.

Zheng, Huilan; Wu, Jingping; Feng, Jinhong et al. · 2024 · Clinical, cosmetic and investigational dermatology · DOI

Full title: Cellular Senescence and Anti-Aging Strategies in Aesthetic Medicine: A Bibliometric Analysis and Brief Review.

Authors: Zheng, Huilan; Wu, Jingping; Feng, Jinhong; Cheng, Hongbin

Year: 2024

Venue: Clinical, cosmetic and investigational dermatology

DOI: https://doi.org/10.2147/CCID.S403417

Paper Age-Related Macular Degeneration: A Disease of Cellular Senescence and Dysregulated Immune Homeostasis

Li, Cunzi; Zhou, Lan; Sun, Hongyan et al. · 2024 · Clinical Interventions in Aging · DOI

Full title: Age-Related Macular Degeneration: A Disease of Cellular Senescence and Dysregulated Immune Homeostasis

Authors: Li, Cunzi; Zhou, Lan; Sun, Hongyan; Yang, Ming

Year: 2024

Venue: Clinical Interventions in Aging

DOI: https://doi.org/10.2147/cia.s463297

Paper Age-Related Pathologies and Life Span

Cocco, Giuseppe; Pandolfi, Stefano · 2023 · OBM Geriatrics · DOI

Full title: Age-Related Pathologies and Life Span

Authors: Cocco, Giuseppe; Pandolfi, Stefano

Year: 2023

Venue: OBM Geriatrics

DOI: https://doi.org/10.21926/obm.geriatr.2304253

Paper The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced Senescence

Liao, Chenxi; Xiao, Yin; Liu, Lingbo · 2020 · Cancer Management and Research · DOI

Full title: The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced Senescence

Authors: Liao, Chenxi; Xiao, Yin; Liu, Lingbo

Year: 2020

Venue: Cancer Management and Research

DOI: https://doi.org/10.2147/cmar.s285083

Paper The Role of Renal Cell Senescence in Diabetic Kidney Disease: Mechanisms and Therapeutic Advances

Yan, Zhang-Yuan; Xu, Juntao; Liu, Tianjiao et al. · 2025 · Diabetes Metabolic Syndrome and Obesity · DOI

Full title: The Role of Renal Cell Senescence in Diabetic Kidney Disease: Mechanisms and Therapeutic Advances

Authors: Yan, Zhang-Yuan; Xu, Juntao; Liu, Tianjiao; Wang, Li; Zhang, Qi; Li, Xiaoling; Lin, Bou‐Wen; Piao, Chunli

Year: 2025

Venue: Diabetes Metabolic Syndrome and Obesity

DOI: https://doi.org/10.2147/dmso.s543814

Paper Genotoxic and Cytotoxic Activity of Fisetin on Glioblastoma Cells

Lea Beltzig; M. Christmann; M. Dobreanu et al. · 2024 · Anticancer Research · DOI

Full title: Genotoxic and Cytotoxic Activity of Fisetin on Glioblastoma Cells

Authors: Lea Beltzig; M. Christmann; M. Dobreanu; Bernd Kaina

Year: 2024

Venue: Anticancer Research

DOI: https://doi.org/10.21873/anticanres.16884

Paper Advances in Nanotherapy for Targeting Senescent Cells.

Shi, Yurou; Zhang, Yingjie; Zhang, Yaxuan et al. · 2024 · International journal of nanomedicine · DOI

Full title: Advances in Nanotherapy for Targeting Senescent Cells.

Authors: Shi, Yurou; Zhang, Yingjie; Zhang, Yaxuan; Yao, Jiali; Guo, Junping; Xu, Xiaoling; Wang, Lijun

Year: 2024

Venue: International journal of nanomedicine

DOI: https://doi.org/10.2147/IJN.S469110

Paper Dasatinib Attenuates Fibrosis in Keloids by Decreasing Senescent Cell Burden

Darmawan, Claudia C.; Hur, Keunyoung; Kusumaningrum, Novi et al. · 2023 · Acta Dermato Venereologica · DOI

Full title: Dasatinib Attenuates Fibrosis in Keloids by Decreasing Senescent Cell Burden

Authors: Darmawan, Claudia C.; Hur, Keunyoung; Kusumaningrum, Novi; Chung, Jin Ho; Lee, Si‐Hyung; Mun, Je‐Ho

Year: 2023

Venue: Acta Dermato Venereologica

DOI: https://doi.org/10.2340/actadv.v103.4475

Paper Platelet Immune Interactions, Lifespan, and Senescence

U. Nydegger; Paul Imbach · 2025 · OBM Geriatrics · DOI

Full title: Platelet Immune Interactions, Lifespan, and Senescence

Authors: U. Nydegger; Paul Imbach

Year: 2025

Venue: OBM Geriatrics

DOI: https://doi.org/10.21926/obm.geriatr.2501297

Paper Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study

Hu, Xiaofen; Li, Ruijie; Sun, Ming et al. · 2021 · Journal of Inflammation Research · DOI

Full title: Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study

Authors: Hu, Xiaofen; Li, Ruijie; Sun, Ming; Kong, Ying; Zhu, Haifeng; Wang, Fujiang; Wan, Quanqing

Year: 2021

Venue: Journal of Inflammation Research

DOI: https://doi.org/10.2147/jir.s299557

Paper The Effect of Physalis angulata L. Administration on Gene Expressions Related to Lung Fibrosis Resolution in Mice-Induced Bleomycin

Imaduddin, Ummul; Berbudi, Afiat; Rohmawaty, Enny · 2024 · Journal of Experimental Pharmacology · DOI

Full title: The Effect of Physalis angulata L. Administration on Gene Expressions Related to Lung Fibrosis Resolution in Mice-Induced Bleomycin

Authors: Imaduddin, Ummul; Berbudi, Afiat; Rohmawaty, Enny

Year: 2024

Venue: Journal of Experimental Pharmacology

DOI: https://doi.org/10.2147/jep.s439932

Paper Quercetin Phospholipids Supplementation as a Natural Relief in Osteomuscular Health

Miniati, Irene; Davolio, Pier Luigi; Busi, Simona et al. · 2024 · Physical Medicine and Rehabilitation - International · DOI

Full title: Quercetin Phospholipids Supplementation as a Natural Relief in Osteomuscular Health

Authors: Miniati, Irene; Davolio, Pier Luigi; Busi, Simona; Petrangolini, Giovanna; Galluccio, Felice; Italy, Farmad Laboratori Firenze Srl, Florence,; Petrangolini, Giovanna; Galluccio, Felice; Italy, Fisiotech Lab Studio, Rheumatology and Pain Management, 50136 Florence,

Year: 2024

Venue: Physical Medicine and Rehabilitation - International

Paper Aging and Senescence Associated Mitochondrial Dysfunction: A Target against Cardiovascular Disorders of the Elderly Individuals

Popov, Lucia-Doina · 2025 · International Journal of Geriatrics and Gerontology · DOI

Full title: Aging and Senescence Associated Mitochondrial Dysfunction: A Target against Cardiovascular Disorders of the Elderly Individuals

Authors: Popov, Lucia-Doina

Year: 2025

Venue: International Journal of Geriatrics and Gerontology

DOI: https://doi.org/10.29011/2577-0748.100098

Paper A food-grade and senescent cell-targeted fisetin delivery system based on whey protein isolate-galactooligosaccharides Maillard conjugate

Hou, Shuai; Lai, Chutong; Song, Yukun et al. · 2023 · Food Science and Human Wellness · DOI

Full title: A food-grade and senescent cell-targeted fisetin delivery system based on whey protein isolate-galactooligosaccharides Maillard conjugate

Authors: Hou, Shuai; Lai, Chutong; Song, Yukun; Wang, Haitao; Ni, Jialu; Tan, Mingqian

Year: 2023

Venue: Food Science and Human Wellness

DOI: https://doi.org/10.26599/fshw.2022.9250058

Paper Сенолитики

A. A. Paltsyn · 2019 · Nauchno-prakticheskii zhurnal «Patogenez» · DOI

Full title: Сенолитики

Authors: A. A. Paltsyn

Year: 2019

Venue: Nauchno-prakticheskii zhurnal «Patogenez»

DOI: https://doi.org/10.25557/2310-0435.2019.04.78-84

Paper Senolytic Development in Osteoarthritis: A New Paradigm

C. Jorgensen · 2021 · Integrative Journal of Orthopaedics and Traumatology · DOI

Full title: Senolytic Development in Osteoarthritis: A New Paradigm

Authors: C. Jorgensen

Year: 2021

Venue: Integrative Journal of Orthopaedics and Traumatology

DOI: https://doi.org/10.31038/ijot.2021422

Paper Targeted regulation of senescence-associated secretory phenotype with an aptamer-conjugated activatable senomorphic

Xie, Yuqi; Li, Jili; Wu, Pingyu et al. · 2023 · Aging Pathobiology and Therapeutics · DOI

Full title: Targeted regulation of senescence-associated secretory phenotype with an aptamer-conjugated activatable senomorphic

Authors: Xie, Yuqi; Li, Jili; Wu, Pingyu; Wang, Linlin; Hong, Donghui; Wang, Jian; Liu, Yanlan

Year: 2023

Venue: Aging Pathobiology and Therapeutics

DOI: https://doi.org/10.31491/apt.2023.06.113

Paper Immunosenescence and Ageing: An Entangled Web of Senescence and Declining Immunity.

Ahmed, Afsar U · 2025 · Frontiers in bioscience (Landmark edition) · DOI

Full title: Immunosenescence and Ageing: An Entangled Web of Senescence and Declining Immunity.

Authors: Ahmed, Afsar U

Year: 2025

Venue: Frontiers in bioscience (Landmark edition)

DOI: https://doi.org/10.31083/FBL42709

Paper Сенолитики

A. A. Paltsyn · 2019 · Nauchno-prakticheskii zhurnal «Patogenez» · DOI

Full title: Сенолитики

Authors: A. A. Paltsyn

Year: 2019

Venue: Nauchno-prakticheskii zhurnal «Patogenez»

DOI: https://doi.org/10.25557/2310-0435.2019.04.78-84

Paper Quantifying the Impact of Treatments on the Recovery of COVID-19 Patients in Twin Cities of Rawalpindi and Islamabad, Pakistan

Akhtar, Hashaam; Ishtiaq, Amna; Chaudhry, Mahnoor et al. · 2023 · BioScientific Review · DOI

Full title: Quantifying the Impact of Treatments on the Recovery of COVID-19 Patients in Twin Cities of Rawalpindi and Islamabad, Pakistan

Authors: Akhtar, Hashaam; Ishtiaq, Amna; Chaudhry, Mahnoor; Khalid, Hasnain; Ilyas, Madiha; Maryam, Fizza; Mughal, Muhammad Maaz; Khan, Muhammad Mujeeb; Jamal, Syed Babar; Faheem, Muhammad

Year: 2023

Venue: BioScientific Review

DOI: https://doi.org/10.32350/bsr.51.06

Paper Cellular Senescence in Non-Small Cell Lung Cancer

Zhu, Huangkai; Sun, Jiaen; Zhang, Chong et al. · 2023 · Frontiers in Bioscience-Landmark · DOI

Full title: Cellular Senescence in Non-Small Cell Lung Cancer

Authors: Zhu, Huangkai; Sun, Jiaen; Zhang, Chong; Li, Pei; Tan, Chuntao; Yang, Minglei; Zhao, Guofang

Year: 2023

Venue: Frontiers in Bioscience-Landmark

DOI: https://doi.org/10.31083/j.fbl2812357

Paper Distinguishing Therapy-Induced Senescence and Polyploid Giant Cancer Cells: Impact on Breast Cancer Chemoresistance

Tatiana Massariol Pimenta; Bárbara da Silva Martins; Josiany Carlos de Souza et al. · 2025 · Cellular Physiology and Biochemistry · DOI

Full title: Distinguishing Therapy-Induced Senescence and Polyploid Giant Cancer Cells: Impact on Breast Cancer Chemoresistance

Authors: Tatiana Massariol Pimenta; Bárbara da Silva Martins; Josiany Carlos de Souza; Milleny Ganho Marçal; Camille Moura Reder; Lavínia Guizan Thiengo; Solenny Maria Silva Butzene; José Matheus Simões Padilha; Luiza Bosi Berger; Leticia Batista Azevedo Rangel

Year: 2025

Venue: Cellular Physiology and Biochemistry

DOI: https://doi.org/10.33594/000000841

Paper The Possible Role of Β-Cell Senescence in the Development of Type 2 Diabetes Mellitus

Novoselova, E. G.; Лунин, С. М.; Хренов, М. О. et al. · 2023 · Cellular Physiology and Biochemistry · DOI

Full title: The Possible Role of Β-Cell Senescence in the Development of Type 2 Diabetes Mellitus

Authors: Novoselova, E. G.; Лунин, С. М.; Хренов, М. О.; Глушкова, О. В.; Novoselova, Tatiana; Parfenyuk, Svetlana B.

Year: 2023

Venue: Cellular Physiology and Biochemistry

DOI: https://doi.org/10.33594/000000606

Paper Potential Role of Cellular Senescence in Asthma

Wang, Zhao-Ni; Su, Ruonan; Yang, Bi-yuan et al. · 2020 · Frontiers in Cell and Developmental Biology · DOI

Full title: Potential Role of Cellular Senescence in Asthma

Authors: Wang, Zhao-Ni; Su, Ruonan; Yang, Bi-yuan; Yang, Kexin; Yang, Lifen; Yan, Yan; Chen, Zhuang‐Gui

Year: 2020

Venue: Frontiers in Cell and Developmental Biology

DOI: https://doi.org/10.3389/fcell.2020.00059

Paper Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds

Wilkinson, Holly N.; Hardman, Matthew J. · 2020 · Frontiers in Cell and Developmental Biology · DOI

Full title: Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds

Authors: Wilkinson, Holly N.; Hardman, Matthew J.

Year: 2020

Venue: Frontiers in Cell and Developmental Biology

DOI: https://doi.org/10.3389/fcell.2020.00773

Paper Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration

Yuhao Wu; Shiwei Shen; Yifeng Shi et al. · 2022 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration

Authors: Yuhao Wu; Shiwei Shen; Yifeng Shi; Naifeng Tian; Yifei Zhou; Xiaolei Zhang

Year: 2022

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2022.823945

Paper Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging.

Thoppil, Harikrishnan; Riabowol, Karl · 2019 · Frontiers in cell and developmental biology · DOI

Full title: Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging.

Authors: Thoppil, Harikrishnan; Riabowol, Karl

Year: 2019

Venue: Frontiers in cell and developmental biology

DOI: https://doi.org/10.3389/fcell.2019.00367

Paper Senescence and the Aging Immune System as Major Drivers of Chronic Kidney Disease

Johannes Schroth; C. Thiemermann; S. Henson · 2020 · Frontiers in Cell and Developmental Biology · DOI

Full title: Senescence and the Aging Immune System as Major Drivers of Chronic Kidney Disease

Authors: Johannes Schroth; C. Thiemermann; S. Henson

Year: 2020

Venue: Frontiers in Cell and Developmental Biology

DOI: https://doi.org/10.3389/fcell.2020.564461

Paper Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development.

Hu, Li; Li, Huiqin; Zi, Meiting et al. · 2022 · Frontiers in cell and developmental biology · DOI

Full title: Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development.

Authors: Hu, Li; Li, Huiqin; Zi, Meiting; Li, Wen; Liu, Jing; Yang, Yang; Zhou, Daohong; Kong, Qing-Peng; Zhang, Yunxia; He, Yonghan

Year: 2022

Venue: Frontiers in cell and developmental biology

DOI: https://doi.org/10.3389/fcell.2022.822816

Paper Cellular senescence in colorectal cancer: its occurrence, effect and therapy.

Liang, Yabing; Wang, Miao; Wang, Xianjue et al. · 2025 · Frontiers in oncology · DOI

Full title: Cellular senescence in colorectal cancer: its occurrence, effect and therapy.

Authors: Liang, Yabing; Wang, Miao; Wang, Xianjue; Yang, Zhiqing; Wang, Shucheng; Li, Fengyi; Su, Liya; Yang, Ling

Year: 2025

Venue: Frontiers in oncology

DOI: https://doi.org/10.3389/fonc.2025.1580951

Paper Cellular senescence: a double-edged sword in cancer therapy

Xiao, Shuai; Qin, Dongmin; Hou, Xueyang et al. · 2023 · Frontiers in Oncology · DOI

Full title: Cellular senescence: a double-edged sword in cancer therapy

Authors: Xiao, Shuai; Qin, Dongmin; Hou, Xueyang; Tian, Lingli; Yu, Yeping; Zhang, Rui; Lyu, Hao; Guo, Dong; Chen, Xing‐Zhen; Zhou, Cefan; Tang, Jingfeng

Year: 2023

Venue: Frontiers in Oncology

DOI: https://doi.org/10.3389/fonc.2023.1189015

Paper The Contribution of Physiological and Accelerated Aging to Cancer Progression Through Senescence-Induced Inflammation

Jorge Morales-Valencia; G. David · 2021 · Frontiers in Oncology · DOI

Full title: The Contribution of Physiological and Accelerated Aging to Cancer Progression Through Senescence-Induced Inflammation

Authors: Jorge Morales-Valencia; G. David

Year: 2021

Venue: Frontiers in Oncology

DOI: https://doi.org/10.3389/fonc.2021.747822

Paper Nanoparticle-mediated delivery of herbal-derived natural products to modulate immunosenescence-induced drug resistance in cancer therapy: a comprehensive review

Lichang Yang; Wei Wu; Jing Yang et al. · 2025 · Frontiers in Oncology · DOI

Full title: Nanoparticle-mediated delivery of herbal-derived natural products to modulate immunosenescence-induced drug resistance in cancer therapy: a comprehensive review

Authors: Lichang Yang; Wei Wu; Jing Yang; Man Xu

Year: 2025

Venue: Frontiers in Oncology

DOI: https://doi.org/10.3389/fonc.2025.1567896

Paper 6-Bromoindirubin-3′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver

Guo, Donghao; Shen, Yun; Li, Wei et al. · 2019 · Frontiers in Pharmacology · DOI

Full title: 6-Bromoindirubin-3′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver

Authors: Guo, Donghao; Shen, Yun; Li, Wei; Li, Qinjie; Zhao, Yu; Pan, Chenhao; Chen, Bi; Zhong, Yuan; Miao, Ya

Year: 2019

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2019.00320

Paper Senolytics (DQ) Mitigates Radiation Ulcers by Removing Senescent Cells

Huilan Wang; Ziwen Wang; Yu Huang et al. · 2020 · Frontiers in Oncology · DOI

Full title: Senolytics (DQ) Mitigates Radiation Ulcers by Removing Senescent Cells

Authors: Huilan Wang; Ziwen Wang; Yu Huang; Yue Zhou; Xiaowu Sheng; Qingzhi Jiang; Yawei Wang; P. Luo; Min Luo; C. Shi

Year: 2020

Venue: Frontiers in Oncology

DOI: https://doi.org/10.3389/fonc.2019.01576

Paper Senescence-Induced Chemoresistance in Triple Negative Breast Cancer and Evolution-Based Treatment Strategies

Chakrabarty, Anindita; Chakraborty, Shayantani; Bhattacharya, Ranjini et al. · 2021 · Frontiers in Oncology · DOI

Full title: Senescence-Induced Chemoresistance in Triple Negative Breast Cancer and Evolution-Based Treatment Strategies

Authors: Chakrabarty, Anindita; Chakraborty, Shayantani; Bhattacharya, Ranjini; Chowdhury, Goutam

Year: 2021

Venue: Frontiers in Oncology

DOI: https://doi.org/10.3389/fonc.2021.674354

Paper Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer

Kristína Kovačovicová; Marianna Skolnaja; Mihkel Heinmaa et al. · 2018 · Frontiers in Oncology · DOI

Full title: Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer

Authors: Kristína Kovačovicová; Marianna Skolnaja; Mihkel Heinmaa; M. Mistrik; P. Pata; I. Pata; J. Bartek; M. Vinciguerra

Year: 2018

Venue: Frontiers in Oncology

DOI: https://doi.org/10.3389/fonc.2018.00459

Paper The BET inhibitor/degrader ARV-825 prolongs the growth arrest response to Fulvestrant + Palbociclib and suppresses proliferative recovery in ER-positive breast cancer

Finnegan, Ryan; Elshazly, Ahmed M.; Patel, Nipa et al. · 2023 · Frontiers in Oncology · DOI

Full title: The BET inhibitor/degrader ARV-825 prolongs the growth arrest response to Fulvestrant + Palbociclib and suppresses proliferative recovery in ER-positive breast cancer

Authors: Finnegan, Ryan; Elshazly, Ahmed M.; Patel, Nipa; Tyutyunyk‐Massey, Liliya; Tran, Tammy H.; Kumarasamy, Vishnu; Knudsen, Erik S.; Gewirtz, David A.

Year: 2023

Venue: Frontiers in Oncology

DOI: https://doi.org/10.3389/fonc.2022.966441

Paper Ionizing Radiation-Induced Cellular Senescence in Normal, Non-transformed Cells and the Involved DNA Damage Response: A Mini Review

Mengqian Li; Liting You; J. Xue et al. · 2018 · Frontiers in Pharmacology · DOI

Full title: Ionizing Radiation-Induced Cellular Senescence in Normal, Non-transformed Cells and the Involved DNA Damage Response: A Mini Review

Authors: Mengqian Li; Liting You; J. Xue; You Lu

Year: 2018

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2018.00522

Paper Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions

Docherty, Marie; Baird, David; Hughes, Jeremy et al. · 2020 · Frontiers in Pharmacology · DOI

Full title: Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions

Authors: Docherty, Marie; Baird, David; Hughes, Jeremy; Ferenbach, David A.

Year: 2020

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2020.00755

Paper Cellular Senescence and the Kidney: Potential Therapeutic Targets and Tools

Sebastian N. Knoppert; F. Valentijn; Tri Q. Nguyen et al. · 2019 · Frontiers in Pharmacology · DOI

Full title: Cellular Senescence and the Kidney: Potential Therapeutic Targets and Tools

Authors: Sebastian N. Knoppert; F. Valentijn; Tri Q. Nguyen; R. Goldschmeding; L. Falke

Year: 2019

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2019.00770

Paper Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies

Xu, Jie; Zhou, Lili; Liu, Youhua · 2020 · Frontiers in Pharmacology · DOI

Full title: Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies

Authors: Xu, Jie; Zhou, Lili; Liu, Youhua

Year: 2020

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2020.601325

Paper SIRT1 Activation by Natural Phytochemicals: An Overview

Iside, Concetta; Scafuro, Marika; Nebbioso, Angela et al. · 2020 · Frontiers in Pharmacology · DOI

Full title: SIRT1 Activation by Natural Phytochemicals: An Overview

Authors: Iside, Concetta; Scafuro, Marika; Nebbioso, Angela; Altucci, Lucia

Year: 2020

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2020.01225

Paper Clinical Review: Navitoclax as a Pro-Apoptotic and Anti-Fibrotic Agent

Anuar, Nur Najmi Mohamad; Hisam, Nur Syahidah Nor; Liew, Sze Ling et al. · 2020 · Frontiers in Pharmacology · DOI

Full title: Clinical Review: Navitoclax as a Pro-Apoptotic and Anti-Fibrotic Agent

Authors: Anuar, Nur Najmi Mohamad; Hisam, Nur Syahidah Nor; Liew, Sze Ling; Ugusman, Azizah

Year: 2020

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2020.564108

Paper Aging, Cell Senescence, the Pathogenesis and Targeted Therapies of Osteoarthritis

Xin-Xin Zhang; Shi-Hao He; Xu Liang et al. · 2021 · Frontiers in Pharmacology · DOI

Full title: Aging, Cell Senescence, the Pathogenesis and Targeted Therapies of Osteoarthritis

Authors: Xin-Xin Zhang; Shi-Hao He; Xu Liang; Wei Li; Tian-Fang Li; Dai-Feng Li

Year: 2021

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2021.728100

Paper Immunological Events, Emerging Pharmaceutical Treatments and Therapeutic Potential of Balneotherapy on Osteoarthritis

Scanu, Anna; Tognolo, Lucrezia; Maccarone, Maria Chiara et al. · 2021 · Frontiers in Pharmacology · DOI

Full title: Immunological Events, Emerging Pharmaceutical Treatments and Therapeutic Potential of Balneotherapy on Osteoarthritis

Authors: Scanu, Anna; Tognolo, Lucrezia; Maccarone, Maria Chiara; Masiero, Stefano

Year: 2021

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2021.681871

Paper Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regeneration, and Therapeutics

Saito, Yuki; Chikenji, Takako · 2021 · Frontiers in Pharmacology · DOI

Full title: Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regeneration, and Therapeutics

Authors: Saito, Yuki; Chikenji, Takako

Year: 2021

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2021.739510

Paper Oridonin Delays Aging Through the AKT Signaling Pathway

An, Yongpan; Zhu, Jie; Wang, Xin et al. · 2022 · Frontiers in Pharmacology · DOI

Full title: Oridonin Delays Aging Through the AKT Signaling Pathway

Authors: An, Yongpan; Zhu, Jie; Wang, Xin; Sun, Xinpei; Luo, Chunxiong; Zhang, Yukun; Ye, Yuwei; Li, Xiaowei; Abulizi, Abudumijiti; Huang, Zhi‐Zhen; Zhang, Hang; Yang, Baoxue; Xie, Zhengwei

Year: 2022

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2022.888247

Paper Yiqi Huayu decoction alleviates bleomycin-induced pulmonary fibrosis in rats by inhibiting senescence

Zuo, Biao; Zuo, Ling; Du, Xuqin et al. · 2022 · Frontiers in Pharmacology · DOI

Full title: Yiqi Huayu decoction alleviates bleomycin-induced pulmonary fibrosis in rats by inhibiting senescence

Authors: Zuo, Biao; Zuo, Ling; Du, Xuqin; Yuan, Su; Xuan, Chen; Zhang, Yudi; Chen, Zhiwei; Cao, Wen-fu

Year: 2022

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2022.1033919

Paper Targeting of non-apoptotic cancer cell death mechanisms by quercetin: Implications in cancer therapy

Yang, Hao; Xu, Shan; Tang, Lidan et al. · 2022 · Frontiers in Pharmacology · DOI

Full title: Targeting of non-apoptotic cancer cell death mechanisms by quercetin: Implications in cancer therapy

Authors: Yang, Hao; Xu, Shan; Tang, Lidan; Gong, Jinhong; Fang, Hufeng; Wei, Ji‐Fu; Su, Dan

Year: 2022

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2022.1043056

Paper A Human Conditionally Immortalized Proximal Tubule Epithelial Cell Line as a Novel Model for Studying Senescence and Response to Senolytics

Yi Yang; M. Mihajlovic; F. Valentijn et al. · 2022 · Frontiers in Pharmacology · DOI

Full title: A Human Conditionally Immortalized Proximal Tubule Epithelial Cell Line as a Novel Model for Studying Senescence and Response to Senolytics

Authors: Yi Yang; M. Mihajlovic; F. Valentijn; Tri Q. Nguyen; R. Goldschmeding; R. Masereeuw

Year: 2022

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2022.791612

Paper Senescent AECⅡ and the implication for idiopathic pulmonary fibrosis treatment

Zhang, Tingwei; Zhang, Jinjin; Lv, Changjun et al. · 2022 · Frontiers in Pharmacology · DOI

Full title: Senescent AECⅡ and the implication for idiopathic pulmonary fibrosis treatment

Authors: Zhang, Tingwei; Zhang, Jinjin; Lv, Changjun; Li, Hongbo; Song, Xiaodong

Year: 2022

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2022.1059434

Paper Pentoxifylline Inhibits Pulmonary Fibrosis by Regulating Cellular Senescence in Mice

Lin, Yifan; Xu, Zhihao; Zhou, Beibei et al. · 2022 · Frontiers in Pharmacology · DOI

Full title: Pentoxifylline Inhibits Pulmonary Fibrosis by Regulating Cellular Senescence in Mice

Authors: Lin, Yifan; Xu, Zhihao; Zhou, Beibei; Ma, Keer; Jiang, Mengyi

Year: 2022

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2022.848263

Paper Perspectives of PDE inhibitor on treating idiopathic pulmonary fibrosis

Yang, Xudan; Xu, Zhihao; Hu, Songhua et al. · 2023 · Frontiers in Pharmacology · DOI

Full title: Perspectives of PDE inhibitor on treating idiopathic pulmonary fibrosis

Authors: Yang, Xudan; Xu, Zhihao; Hu, Songhua; Shen, Juan

Year: 2023

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2023.1111393

Paper Senolytics in the treatment of diabetic retinopathy

Hassan, Jannah Waled; Bhatwadekar, Ashay D. · 2022 · Frontiers in Pharmacology · DOI

Full title: Senolytics in the treatment of diabetic retinopathy

Authors: Hassan, Jannah Waled; Bhatwadekar, Ashay D.

Year: 2022

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2022.896907

Paper The interaction between cellular senescence and chronic kidney disease as a therapeutic opportunity

Zhao, Jing-Li; Qiao, Xiao-Hui; Mao, Jianhua et al. · 2022 · Frontiers in Pharmacology · DOI

Full title: The interaction between cellular senescence and chronic kidney disease as a therapeutic opportunity

Authors: Zhao, Jing-Li; Qiao, Xiao-Hui; Mao, Jianhua; Liu, Fei; Fu, Haidong

Year: 2022

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2022.974361

Paper Skin aging from mechanisms to interventions: focusing on dermal aging

Shin, Sun Hye; Lee, Yoon Hwan; Rho, Nark‐Kyoung et al. · 2023 · Frontiers in Physiology · DOI

Full title: Skin aging from mechanisms to interventions: focusing on dermal aging

Authors: Shin, Sun Hye; Lee, Yoon Hwan; Rho, Nark‐Kyoung; Park, Kui Young

Year: 2023

Venue: Frontiers in Physiology

DOI: https://doi.org/10.3389/fphys.2023.1195272

Paper Recent advances in dermal fibroblast senescence and skin aging: unraveling mechanisms and pioneering therapeutic strategies.

Nan, Li; Guo, Pengchao; Hui, Wang et al. · 2025 · Frontiers in pharmacology · DOI

Full title: Recent advances in dermal fibroblast senescence and skin aging: unraveling mechanisms and pioneering therapeutic strategies.

Authors: Nan, Li; Guo, Pengchao; Hui, Wang; Xia, Fang; Yi, Chenggang

Year: 2025

Venue: Frontiers in pharmacology

DOI: https://doi.org/10.3389/fphar.2025.1592596

Paper Senolytic effect of triterpenoid complex from Ganoderma lucidum on adriamycin-induced senescent human hepatocellular carcinoma cells model in vitro and in vivo.

Abdelmoaty, Ahmed Attia Ahmed; Chen, Jing; Zhang, Kun et al. · 2024 · Frontiers in pharmacology · DOI

Full title: Senolytic effect of triterpenoid complex from Ganoderma lucidum on adriamycin-induced senescent human hepatocellular carcinoma cells model in vitro and in vivo.

Authors: Abdelmoaty, Ahmed Attia Ahmed; Chen, Jing; Zhang, Kun; Wu, Changhui; Li, Ye; Li, Peng; Xu, Jianhua

Year: 2024

Venue: Frontiers in pharmacology

DOI: https://doi.org/10.3389/fphar.2024.1422363

Paper Dynamic Aging: Channeled Through Microenvironment

Tan, Qing; Liang, Na; Zhang, Xiaoqian et al. · 2021 · Frontiers in Physiology · DOI

Full title: Dynamic Aging: Channeled Through Microenvironment

Authors: Tan, Qing; Liang, Na; Zhang, Xiaoqian; Li, Jun

Year: 2021

Venue: Frontiers in Physiology

DOI: https://doi.org/10.3389/fphys.2021.702276

Paper Cerebral Microvascular Senescence and Inflammation in Diabetes

Phoenix, Ashley; Chandran, Raghavendar; Ergul, Adviye · 2022 · Frontiers in Physiology · DOI

Full title: Cerebral Microvascular Senescence and Inflammation in Diabetes

Authors: Phoenix, Ashley; Chandran, Raghavendar; Ergul, Adviye

Year: 2022

Venue: Frontiers in Physiology

DOI: https://doi.org/10.3389/fphys.2022.864758

Paper Research and publication trends on knee osteoarthritis and cellular senescence: a bibliometric analysis

Wang, Shuai; Yang, Jiyong; Xiang, Ruian et al. · 2023 · Frontiers in Physiology · DOI

Full title: Research and publication trends on knee osteoarthritis and cellular senescence: a bibliometric analysis

Authors: Wang, Shuai; Yang, Jiyong; Xiang, Ruian; Li, Congcong; Li, Junyi; Shen, Xingxing; Liu, Wengang; Xu, Xuemeng

Year: 2023

Venue: Frontiers in Physiology

DOI: https://doi.org/10.3389/fphys.2023.1269338

Paper Removal of p16INK4 Expressing Cells in Late Life has Moderate Beneficial Effects on Skeletal Muscle Function in Male Mice

Guzman, Steve D.; Judge, Jennifer; Shigdar, Shahjahan et al. · 2022 · Frontiers in Aging · DOI

Full title: Removal of p16INK4 Expressing Cells in Late Life has Moderate Beneficial Effects on Skeletal Muscle Function in Male Mice

Authors: Guzman, Steve D.; Judge, Jennifer; Shigdar, Shahjahan; Paul, Thomas A.; Davis, Carol; Macpherson, Peter; Markworth, James F.; Remmen, Holly Van; Richardson, Arlan; McArdle, Anne; Brooks, Susan V.

Year: 2022

Venue: Frontiers in Aging

DOI: https://doi.org/10.3389/fragi.2021.821904

Paper The Promise of a Golden Era for Exploring the Frontiers of Aging, Metabolism and Redox Biology

Zhang, Jianhua · 2020 · Frontiers in Aging · DOI

Full title: The Promise of a Golden Era for Exploring the Frontiers of Aging, Metabolism and Redox Biology

Authors: Zhang, Jianhua

Year: 2020

Venue: Frontiers in Aging

DOI: https://doi.org/10.3389/fragi.2020.610406

Paper MicroRNA-34a: A Novel Therapeutic Target in Fibrosis

Zhao, Min; Qi, Qin; Liu, Shimin et al. · 2022 · Frontiers in Physiology · DOI

Full title: MicroRNA-34a: A Novel Therapeutic Target in Fibrosis

Authors: Zhao, Min; Qi, Qin; Liu, Shimin; Huang, R. Stephanie; Shen, Jiacheng; Zhu, Yi; Chai, Jing; Zheng, Handan; Wu, Huangan; Liu, Huirong

Year: 2022

Venue: Frontiers in Physiology

DOI: https://doi.org/10.3389/fphys.2022.895242

Paper The role of cellular senescence in skin aging and age-related skin pathologies

Chin, Toby; Lee, Xin Er; Ng, Pei Yi et al. · 2023 · Frontiers in Physiology · DOI

Full title: The role of cellular senescence in skin aging and age-related skin pathologies

Authors: Chin, Toby; Lee, Xin Er; Ng, Pei Yi; Lee, Yaelim; Dreesen, Oliver

Year: 2023

Venue: Frontiers in Physiology

DOI: https://doi.org/10.3389/fphys.2023.1297637

Paper Impact of senolytic treatment on immunity, aging, and disease

Erica C. Lorenzo; Blake L. Torrance; Laura Haynes · 2023 · Frontiers in Aging · DOI

Full title: Impact of senolytic treatment on immunity, aging, and disease

Authors: Erica C. Lorenzo; Blake L. Torrance; Laura Haynes

Year: 2023

Venue: Frontiers in Aging

DOI: https://doi.org/10.3389/fragi.2023.1161799

Paper Towards AI-driven longevity research: An overview

Marino, Nicola; Putignano, Guido; Cappilli, Simone et al. · 2023 · Frontiers in Aging · DOI

Full title: Towards AI-driven longevity research: An overview

Authors: Marino, Nicola; Putignano, Guido; Cappilli, Simone; Chersoni, Emmanuele; Chadha, Antonella Santuccione; Calabrese, Giuliana; Bischof, Evelyne; Vanhaelen, Quentin; Zhavoronkov, Alex; Scarano, Bryan; Mazzotta, Alessandro; Santus, Enrico

Year: 2023

Venue: Frontiers in Aging

DOI: https://doi.org/10.3389/fragi.2023.1057204

Paper Cellular Senescence and Ageing: Mechanisms and Interventions

Mylonas, Andreas; O’Loghlen, Ana · 2022 · Frontiers in Aging · DOI

Full title: Cellular Senescence and Ageing: Mechanisms and Interventions

Authors: Mylonas, Andreas; O’Loghlen, Ana

Year: 2022

Venue: Frontiers in Aging

DOI: https://doi.org/10.3389/fragi.2022.866718

Paper Inflammasome activation and accelerated immune aging in autoimmune disorders.

Mittal, Rahul; Saavedra, Danay; Mittal, Mannat et al. · 2025 · Frontiers in aging · DOI

Full title: Inflammasome activation and accelerated immune aging in autoimmune disorders.

Authors: Mittal, Rahul; Saavedra, Danay; Mittal, Mannat; Lemos, Joana R N; Hirani, Khemraj

Year: 2025

Venue: Frontiers in aging

DOI: https://doi.org/10.3389/fragi.2025.1688060

Paper Persistent elevation of plasma markers of cellular senescence after hip fracture: a pilot longitudinal study

Eric J. Lenze; Ginger E. Nicol; George A. Kuchel et al. · 2024 · Frontiers in Aging · DOI

Full title: Persistent elevation of plasma markers of cellular senescence after hip fracture: a pilot longitudinal study

Authors: Eric J. Lenze; Ginger E. Nicol; George A. Kuchel; M. S. Avidan; B. Diniz

Year: 2024

Venue: Frontiers in Aging

DOI: https://doi.org/10.3389/fragi.2024.1477528

Paper Clinical Trials Targeting Aging

Nielsen, Johannes Leth; Bakula, Daniela; Scheibye‐Knudsen, Morten · 2022 · Frontiers in Aging · DOI

Full title: Clinical Trials Targeting Aging

Authors: Nielsen, Johannes Leth; Bakula, Daniela; Scheibye‐Knudsen, Morten

Year: 2022

Venue: Frontiers in Aging

DOI: https://doi.org/10.3389/fragi.2022.820215

Paper Urothelial Senescence in the Pathophysiology of Diabetic Bladder Dysfunction—A Novel Hypothesis

Klee, Nicole; McCarthy, Cameron G.; Lewis, Steven et al. · 2018 · Frontiers in Surgery · DOI

Full title: Urothelial Senescence in the Pathophysiology of Diabetic Bladder Dysfunction—A Novel Hypothesis

Authors: Klee, Nicole; McCarthy, Cameron G.; Lewis, Steven; McKenzie, Jaine; Vincent, Julie; Webb, R. Clinton

Year: 2018

Venue: Frontiers in Surgery

DOI: https://doi.org/10.3389/fsurg.2018.00072

Paper Editorial: One Step at a Time: Advances in Osteoarthritis

Mobasheri, Ali; Trumble, Troy N.; Byron, Christopher R. · 2021 · Frontiers in Veterinary Science · DOI

Full title: Editorial: One Step at a Time: Advances in Osteoarthritis

Authors: Mobasheri, Ali; Trumble, Troy N.; Byron, Christopher R.

Year: 2021

Venue: Frontiers in Veterinary Science

DOI: https://doi.org/10.3389/fvets.2021.727477

Paper Cellular senescence in age-related cardiovascular disease: past and future.

Wu, Xiang; Zhou, Qingyu; Huang, Yingying et al. · 2025 · Frontiers in aging · DOI

Full title: Cellular senescence in age-related cardiovascular disease: past and future.

Authors: Wu, Xiang; Zhou, Qingyu; Huang, Yingying; Jiang, Wangqing; Zhou, Jianming; Qian, Ke; Pan, Yinchen; Wu, Zuyao; Zhang, Jingjun; Aimaiti, Madinai; Zhou, Qi; Lv, Feizhou; Lin, Yong; Li, Shaomin; Chen, Shuying

Year: 2025

Venue: Frontiers in aging

DOI: https://doi.org/10.3389/fragi.2025.1721744

Paper - **Journal:** Signal Transduction and Targeted Therapy - **Source:** openalex - **Content Type:** Full text

Ji, Shuaifei; Xiong, Mingchen; Chen, Huating et al. · 2023 · Signal Transduction and Targeted Therapy · DOI

Full title: - **Journal:** Signal Transduction and Targeted Therapy - **Source:** openalex - **Content Type:** Full text

Authors: Ji, Shuaifei; Xiong, Mingchen; Chen, Huating; Liu, Yiqiong; Zhou, Laixian; Hong, Yiyue; Wang, Mengyang; Wang, Chunming; Fu, Xiaobing; Sun, Xiaoyan

Year: 2023

Venue: Signal Transduction and Targeted Therapy

DOI: https://doi.org/10.1038/s41392-023-01343-5

Paper Virus-induced senescence is a driver and therapeutic target in COVID-19

Soyoung Lee; Yong Yu; Jakob Trimpert et al. · 2021 · Nature · DOI

Full title: Virus-induced senescence is a driver and therapeutic target in COVID-19

Authors: Soyoung Lee; Yong Yu; Jakob Trimpert; Fahad Benthani; Mario Mairhofer; Paulina Richter-Pechanska; E. Wyler; D. Belenki; Sabine Kaltenbrunner; Maria Pammer; Lea Kausche; T. Firsching; K. Dietert; M. Schotsaert; Carles Martínez-Romero; Gagandeep Singh; Séverine Kunz; Daniela Niemeyer; Riad Ghanem; H. Salzer; C. Paar; M. Mülleder; Melissa B. Uccellini; E. Michaelis; Amjad Khan; Andrea Lau; Martin Schönlein; Anna Habringer; J. Tomasits; J. Adler; S. Kimeswenger; A. Gruber; W. Hoetzenecker; H. Steinkellner; B. Purfürst; Reinhard Motz; F. Di Pierro; B. Lamprecht; N. Osterrieder; M. Landthaler; C. Drosten; A. García-Sastre; R. Langer; M. Ralser; R. Eils; M. Reimann; D. N. Fan; C. Schmitt

Year: 2021

Venue: Nature

DOI: https://doi.org/10.1038/s41586-021-03995-1

Paper The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice

Qixia Xu; Q. Fu; Zi Li et al. · 2021 · Nature Metabolism · DOI

Full title: The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice

Authors: Qixia Xu; Q. Fu; Zi Li; Hanxin Liu; Ying Wang; X. Lin; Ruikun He; Xuguang Zhang; Z. Ju; J. Campisi; J. Kirkland; Yu Sun

Year: 2021

Venue: Nature Metabolism

DOI: https://doi.org/10.1038/s42255-021-00491-8

Paper Targeting cIAP2 in a novel senolytic strategy prevents glioblastoma recurrence after radiotherapy

N. Tomimatsu; Luis Fernando Macedo Di Cristofaro; Suman Kanji et al. · 2025 · EMBO Molecular Medicine · DOI

Full title: Targeting cIAP2 in a novel senolytic strategy prevents glioblastoma recurrence after radiotherapy

Authors: N. Tomimatsu; Luis Fernando Macedo Di Cristofaro; Suman Kanji; Lorena Samentar; B. Jordan; Ralf Kittler; A. Habib; J. Espindola-Netto; T. Tchkonia; James L. Kirkland; Terry C Burns; J. Sarkaria; Andrea Gilbert; John R Floyd; R. Hromas; Weixing Zhao; Daohong Zhou; Patrick Sung; Bipasha Mukherjee; S. Burma

Year: 2025

Venue: EMBO Molecular Medicine

DOI: https://doi.org/10.1038/s44321-025-00201-x

Paper Single Cell Transcriptomics Reveals Global Markers of Transcriptional Diversity Across Different Forms of Cellular Senescence

Shane A. Evans; Yee Voan Teo; K. Clark et al. · 2021 · bioRxiv · DOI

Full title: Single Cell Transcriptomics Reveals Global Markers of Transcriptional Diversity Across Different Forms of Cellular Senescence

Authors: Shane A. Evans; Yee Voan Teo; K. Clark; Takahiro Ito; J. Sedivy; N. Neretti

Year: 2021

Venue: bioRxiv

DOI: https://doi.org/10.12688/f1000research.7821.1

Paper Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseases

Qixia Xu; Q. Fu; Zi Li et al. · 2021 · bioRxiv · DOI

Full title: Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseases

Authors: Qixia Xu; Q. Fu; Zi Li; Hanxin Liu; Ying Wang; X. Lin; Ruikun He; Xuguang Zhang; J. Campisi; J. Kirkland; Yu Sun

Year: 2021

Venue: bioRxiv

DOI: https://doi.org/10.1101/2021.04.14.439765

Paper Regulation of cellular senescence in tumor progression and therapeutic targeting: mechanisms and pathways.

Liu, Bowei; Peng, Zhigang; Zhang, Hao et al. · 2025 · Molecular cancer · DOI

Full title: Regulation of cellular senescence in tumor progression and therapeutic targeting: mechanisms and pathways.

Authors: Liu, Bowei; Peng, Zhigang; Zhang, Hao; Zhang, Nan; Liu, Zaoqu; Xia, Zhiwei; Huang, Shaorong; Luo, Peng; Cheng, Quan

Year: 2025

Venue: Molecular cancer

DOI: https://doi.org/10.1186/s12943-025-02284-z

Paper The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy

Luhong Cao; Kaixiu Li; Qiang Li et al. · 2025 · Molecular Cancer · DOI

Full title: The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy

Authors: Luhong Cao; Kaixiu Li; Qiang Li; Qiang Tong; Yi Wang; Linxue Huang

Year: 2025

Venue: Molecular Cancer

DOI: https://doi.org/10.1186/s12943-025-02475-8

Paper Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges

Qianwen Liu; Jingfeng Li; Xiuqiao Sun et al. · 2025 · Journal of Hematology & Oncology · DOI

Full title: Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges

Authors: Qianwen Liu; Jingfeng Li; Xiuqiao Sun; Jiayu Lin; Zhengwei Yu; Yue Xiao; Dan Li; Baofa Sun; Haili Bao; Yihao Liu

Year: 2025

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-025-01735-w

Paper Modeling DNA damage-induced pneumopathy in mice: insight from danger signaling cascades

Wirsdörfer, Florian; Jendrossek, Verena · 2017 · Radiation Oncology · DOI

Full title: Modeling DNA damage-induced pneumopathy in mice: insight from danger signaling cascades

Authors: Wirsdörfer, Florian; Jendrossek, Verena

Year: 2017

Venue: Radiation Oncology

DOI: https://doi.org/10.1186/s13014-017-0865-1

Paper A human neuron Alzheimer’s disease model reveals barriers to senolytic translatability

C. C. Walton; Ellen Wang; Suckwon Lee et al. · 2025 · bioRxiv · DOI

Full title: A human neuron Alzheimer’s disease model reveals barriers to senolytic translatability

Authors: C. C. Walton; Ellen Wang; Suckwon Lee; Cynthia J. Siebrand; Nicholas J. Bergo; Julie K. Andersen

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1186/s13195-025-01822-7

Paper Finding Ponce de Leon’s Pill: Challenges in Screening for Anti-Aging Molecules

Kumar, Surinder; Lombard, David B. · 2016 · F1000Research · DOI

Full title: Finding Ponce de Leon’s Pill: Challenges in Screening for Anti-Aging Molecules

Authors: Kumar, Surinder; Lombard, David B.

Year: 2016

Venue: F1000Research

Paper Targeting Crosstalk of Signaling Pathways among Muscles-Bone-Adipose Tissue: A Promising Therapeutic Approach for Sarcopenia

Sharma, Ashish Ranjan; Chatterjee, Srijan; Lee, Yeon‐Hee et al. · 2023 · Aging and Disease · DOI

Full title: Targeting Crosstalk of Signaling Pathways among Muscles-Bone-Adipose Tissue: A Promising Therapeutic Approach for Sarcopenia

Authors: Sharma, Ashish Ranjan; Chatterjee, Srijan; Lee, Yeon‐Hee; Lee, Sang‐Soo

Year: 2023

Venue: Aging and Disease

DOI: https://doi.org/10.14336/ad.2023.00903

Paper Mechanisms Underlying Vascular Inflammaging: Current Insights and Potential Treatment Approaches

Zeng, Ying; Buonfiglio, Francesco; Li, Jingyan et al. · 2025 · Aging and Disease · DOI

Full title: Mechanisms Underlying Vascular Inflammaging: Current Insights and Potential Treatment Approaches

Authors: Zeng, Ying; Buonfiglio, Francesco; Li, Jingyan; Pfeiffer, Norbert; Gericke, Adrian

Year: 2025

Venue: Aging and Disease

DOI: https://doi.org/10.14336/ad.2024.0922

Paper Telomeres: Dysfunction, Maintenance, Aging and Cancer

Liao, Pan; Yan, Bo; Wang, Conglin et al. · 2023 · Aging and Disease · DOI

Full title: Telomeres: Dysfunction, Maintenance, Aging and Cancer

Authors: Liao, Pan; Yan, Bo; Wang, Conglin; Lei, Ping

Year: 2023

Venue: Aging and Disease

DOI: https://doi.org/10.14336/ad.2023.1128

Paper Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies

Zheng, Liyao; He, Shipei; Wang, Hong et al. · 2024 · Aging and Disease · DOI

Full title: Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies

Authors: Zheng, Liyao; He, Shipei; Wang, Hong; Li, Jinling; Liu, Yuanyuan; Liu, Sijia

Year: 2024

Venue: Aging and Disease

DOI: https://doi.org/10.14336/ad.2024.0206

Paper Senescence in Aging and Alzheimer's Disease.

Sun, Li; Chen, Chu · 2025 · Aging and disease · DOI

Full title: Senescence in Aging and Alzheimer's Disease.

Authors: Sun, Li; Chen, Chu

Year: 2025

Venue: Aging and disease

DOI: https://doi.org/10.14336/AD.2025.1201

Paper IMPACT OF VIRUSES AND RETROTRASPOSONS ON GENETIC INSTABILITY AND AGING

Elena V. Lysakova; Marina Burak; Maxim Navrotsky et al. · 2025 · Russian Journal of Infection and Immunity · DOI

Full title: IMPACT OF VIRUSES AND RETROTRASPOSONS ON GENETIC INSTABILITY AND AGING

Authors: Elena V. Lysakova; Marina Burak; Maxim Navrotsky; S. Rybtsov

Year: 2025

Venue: Russian Journal of Infection and Immunity

DOI: https://doi.org/10.15789/2220-7619-iov-17834

Paper Traditional herbs: mechanisms to combat cellular senescence

Wang, Lei; Wang, Jiahui; Yang, Zhihui et al. · 2023 · Aging · DOI

Full title: Traditional herbs: mechanisms to combat cellular senescence

Authors: Wang, Lei; Wang, Jiahui; Yang, Zhihui; Wang, Yue; Zhao, Tiejian; Luo, Wei‐Sheng; Liang, Tianjian; Zheng, Yang

Year: 2023

Venue: Aging

DOI: https://doi.org/10.18632/aging.205269

Paper Mechanisms of cellular senescence-induced vascular aging: evidence of senotherapeutic strategies.

Mahoney, Sophia A; Bloom, Samuel I; Seals, Douglas R et al. · 2025 · The journal of cardiovascular aging · DOI

Full title: Mechanisms of cellular senescence-induced vascular aging: evidence of senotherapeutic strategies.

Authors: Mahoney, Sophia A; Bloom, Samuel I; Seals, Douglas R; Donato, Anthony J; Rossman, Matthew J; Clayton, Zachary S

Year: 2025

Venue: The journal of cardiovascular aging

DOI: https://doi.org/10.20517/jca.2024.31

Paper DNA damage response &amp; senescence-associated secretory phenotype pathway: Emerging targets for anti-aging

Nadeem, Jawad; Parveen, Amna; Kim, Sun Yeou · 2023 · Preprints.org · DOI

Full title: DNA damage response &amp; senescence-associated secretory phenotype pathway: Emerging targets for anti-aging

Authors: Nadeem, Jawad; Parveen, Amna; Kim, Sun Yeou

Year: 2023

Venue: Preprints.org

DOI: https://doi.org/10.20944/preprints202309.1932.v1

Paper Heterogeneity of Cellular Senescence, Senotyping, and Targeting by Senolytics and Senomorphics in Lung Diseases.

Ozdemir, Said Ali; Faizan, Md Imam; Kaur, Gagandeep et al. · 2025 · International journal of molecular sciences · DOI

Full title: Heterogeneity of Cellular Senescence, Senotyping, and Targeting by Senolytics and Senomorphics in Lung Diseases.

Authors: Ozdemir, Said Ali; Faizan, Md Imam; Kaur, Gagandeep; Shaikh, Sadiya Bi; Ul Islam, Khursheed; Rahman, Irfan

Year: 2025

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms26199687

Paper Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics.

Alum, Esther Ugo; Izah, Sylvester Chibueze; Uti, Daniel Ejim et al. · 2025 · Drug design, development and therapy · DOI

Full title: Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics.

Authors: Alum, Esther Ugo; Izah, Sylvester Chibueze; Uti, Daniel Ejim; Ugwu, Okechukwu Paul-Chima; Betiang, Peter A; Basajja, Mariam; Ejemot-Nwadiaro, Regina Idu

Year: 2025

Venue: Drug design, development and therapy

DOI: https://doi.org/10.2147/DDDT.S543211

Paper Vascular Aging: Assessment and Intervention

Li, Ao; Yan, Jinhua; Ya, Zhao et al. · 2023 · Clinical Interventions in Aging · DOI

Full title: Vascular Aging: Assessment and Intervention

Authors: Li, Ao; Yan, Jinhua; Ya, Zhao; Yu, Zhenping; Tian, Shane; Khan, Abdul Haseeb; Zhu, Yuanzheng; Wu, Andong; Zhang, Cuntai; Tian, Xiao‐Li

Year: 2023

Venue: Clinical Interventions in Aging

DOI: https://doi.org/10.2147/cia.s423373

Paper Materials, Syntheses and Biomedical Applications of Nano-Quercetin Formulations: A Comprehensive Literature Review

Wang, Han; Di, Wenli; Gao, Xibao et al. · 2025 · International Journal of Nanomedicine · DOI

Full title: Materials, Syntheses and Biomedical Applications of Nano-Quercetin Formulations: A Comprehensive Literature Review

Authors: Wang, Han; Di, Wenli; Gao, Xibao; Guo, Yuanyuan; Tang, Tian; Bai, Xue; Cao, Hongqian

Year: 2025

Venue: International Journal of Nanomedicine

DOI: https://doi.org/10.2147/ijn.s517079

Paper Insights into protein-bound uremic toxins in proximal tubule cell senescence and kidney fibrosis

Yi Yang · DOI

Full title: Insights into protein-bound uremic toxins in proximal tubule cell senescence and kidney fibrosis

Authors: Yi Yang

DOI: https://doi.org/10.33540/1996

Paper Cellular microenvironment: a key for tuning mesenchymal stem cell senescence

Sun, Wenyang; Lv, Jiacheng; Guo, Shu et al. · 2023 · Frontiers in Cell and Developmental Biology · DOI

Full title: Cellular microenvironment: a key for tuning mesenchymal stem cell senescence

Authors: Sun, Wenyang; Lv, Jiacheng; Guo, Shu; Lv, Mengzhu

Year: 2023

Venue: Frontiers in Cell and Developmental Biology

DOI: https://doi.org/10.3389/fcell.2023.1323678

Paper Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases.

Dagher, Olina; Mury, Pauline; Thorin-Trescases, Nathalie et al. · 2021 · Frontiers in cardiovascular medicine · DOI

Full title: Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases.

Authors: Dagher, Olina; Mury, Pauline; Thorin-Trescases, Nathalie; Noly, Pierre Emmanuel; Thorin, Eric; Carrier, Michel

Year: 2021

Venue: Frontiers in cardiovascular medicine

DOI: https://doi.org/10.3389/fcvm.2021.658400

Paper Aging and Options to Halt Declining Immunity to Virus Infections

Palacios-Pedrero, Miguel Ángel; Osterhaus, Albert; Becker, Tanja et al. · 2021 · Frontiers in Immunology · DOI

Full title: Aging and Options to Halt Declining Immunity to Virus Infections

Authors: Palacios-Pedrero, Miguel Ángel; Osterhaus, Albert; Becker, Tanja; Elbahesh, Husni; Rimmelzwaan, Guus F.; Saletti, Giulietta

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.681449

Paper Composition and regulation of the immune microenvironment of salivary gland in Sjögren’s syndrome

Tan, Zhen; Wang, Li; Li, Xiaomei · 2022 · Frontiers in Immunology · DOI

Full title: Composition and regulation of the immune microenvironment of salivary gland in Sjögren’s syndrome

Authors: Tan, Zhen; Wang, Li; Li, Xiaomei

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.967304

Paper Understanding NK cell biology for harnessing NK cell therapies: targeting cancer and beyond

Shin, Eunju; Bak, Seong Ho; Park, Tae‐Ho et al. · 2023 · Frontiers in Immunology · DOI

Full title: Understanding NK cell biology for harnessing NK cell therapies: targeting cancer and beyond

Authors: Shin, Eunju; Bak, Seong Ho; Park, Tae‐Ho; Kim, Jin-Woo; Yoon, Suk-Ran; Jung, Haiyoung; Noh, Ji‐Yoon

Year: 2023

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2023.1192907

Paper Immune cell senescence in autoimmunity: implications for disease pathogenesis and therapeutic targeting.

Yin, Fei; He, Yangfang; Li, Jian et al. · 2025 · Frontiers in immunology · DOI

Full title: Immune cell senescence in autoimmunity: implications for disease pathogenesis and therapeutic targeting.

Authors: Yin, Fei; He, Yangfang; Li, Jian; Gao, Yuan

Year: 2025

Venue: Frontiers in immunology

DOI: https://doi.org/10.3389/fimmu.2025.1596686

Paper Senescence in Pulmonary Fibrosis: Between Aging and Exposure

Venosa, Alessandro · 2020 · Frontiers in Medicine · DOI

Full title: Senescence in Pulmonary Fibrosis: Between Aging and Exposure

Authors: Venosa, Alessandro

Year: 2020

Venue: Frontiers in Medicine

DOI: https://doi.org/10.3389/fmed.2020.606462

Paper Cellular Senescence in Brain Aging

E. Sikora; A. Bielak-Zmijewska; M. Dudkowska et al. · 2021 · Frontiers in Aging Neuroscience · DOI

Full title: Cellular Senescence in Brain Aging

Authors: E. Sikora; A. Bielak-Zmijewska; M. Dudkowska; A. Krzystyniak; G. Mosieniak; M. Węsierska; J. Włodarczyk

Year: 2021

Venue: Frontiers in Aging Neuroscience

DOI: https://doi.org/10.3389/fnagi.2021.646924

Paper Targeting Premature Renal Aging: from Molecular Mechanisms of Cellular Senescence to Senolytic Trials.

Franzin, Rossana; Stasi, Alessandra; Ranieri, Elena et al. · 2021 · Frontiers in pharmacology · DOI

Full title: Targeting Premature Renal Aging: from Molecular Mechanisms of Cellular Senescence to Senolytic Trials.

Authors: Franzin, Rossana; Stasi, Alessandra; Ranieri, Elena; Netti, Giuseppe Stefano; Cantaluppi, Vincenzo; Gesualdo, Loreto; Stallone, Giovanni; Castellano, Giuseppe

Year: 2021

Venue: Frontiers in pharmacology

DOI: https://doi.org/10.3389/fphar.2021.630419

Paper Research Progress in the Molecular Mechanisms, Therapeutic Targets, and Drug Development of Idiopathic Pulmonary Fibrosis

Ma, Hongbo; Wu, Xuyi; Li, Yi et al. · 2022 · Frontiers in Pharmacology · DOI

Full title: Research Progress in the Molecular Mechanisms, Therapeutic Targets, and Drug Development of Idiopathic Pulmonary Fibrosis

Authors: Ma, Hongbo; Wu, Xuyi; Li, Yi; Xia, Yong

Year: 2022

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2022.963054

Paper Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities

Sun, Xinghui; Feinberg, Mark W. · 2021 · Frontiers in Physiology · DOI

Full title: Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities

Authors: Sun, Xinghui; Feinberg, Mark W.

Year: 2021

Venue: Frontiers in Physiology

DOI: https://doi.org/10.3389/fphys.2021.693067

Paper Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models.

Inci, Nurcan; Kamali, Dilanur; Akyildiz, Erdogan Oguzhan et al. · 2022 · Frontiers in aging · DOI

Full title: Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models.

Authors: Inci, Nurcan; Kamali, Dilanur; Akyildiz, Erdogan Oguzhan; Tahir Turanli, Eda; Bozaykut, Perinur

Year: 2022

Venue: Frontiers in aging

DOI: https://doi.org/10.3389/fragi.2022.828058

Paper Senesens. Heart. Senotherapy

S. A. Kryzhanovskii; M. Vititnova · 2024 · Pharmacokinetics and Pharmacodynamics · DOI

Full title: Senesens. Heart. Senotherapy

Authors: S. A. Kryzhanovskii; M. Vititnova

Year: 2024

Venue: Pharmacokinetics and Pharmacodynamics

DOI: https://doi.org/10.37489/2588-0519-2024-3-3-19

Paper The Dual Role of Cellular Senescence in Macrophages: Unveiling the Hidden Driver of Age-Related Inflammation in Kidney Disease

Wang, Yibing; Li, Tong; Wang, Fengyu et al. · 2024 · International Journal of Biological Sciences · DOI

Full title: The Dual Role of Cellular Senescence in Macrophages: Unveiling the Hidden Driver of Age-Related Inflammation in Kidney Disease

Authors: Wang, Yibing; Li, Tong; Wang, Fengyu; Yao, Xin; Bai, Qianrong; Su, Hong-Wei; Li, Jian; Li, Wang; Tan, Ruizhi

Year: 2024

Venue: International Journal of Biological Sciences

DOI: https://doi.org/10.7150/ijbs.104404

Paper A senolysis-based theragnostic prodrug strategy towards chronic renal failure

Song, Yihe; Li, Xinming; Shi, Donglei et al. · 2022 · Chemical Science · DOI

Full title: A senolysis-based theragnostic prodrug strategy towards chronic renal failure

Authors: Song, Yihe; Li, Xinming; Shi, Donglei; Sun, Tianyue; Liu, Wenwen; Li, Xiaokang; Qiao, Sicong; Chen, Xin; Guo, Yuan; Li, Jian

Year: 2022

Venue: Chemical Science

DOI: https://doi.org/10.1039/d2sc03525a

Paper Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

Julio Aguado; Alberto A. Amarilla; Atefeh Taherian Fard et al. · 2023 · bioRxiv · DOI

Full title: Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

Authors: Julio Aguado; Alberto A. Amarilla; Atefeh Taherian Fard; Eduardo A. Albornoz; A. Tyshkovskiy; Marius Schwabenland; H. Chaggar; Naphak Modhiran; Cecilia Gómez-Inclán; Ibrahim Javed; Alireza A. Baradar; Benjamin Liang; Lianli Peng; Malindrie Dharmaratne; Giovanni Pietrogrande; P. Padmanabhan; Morgan E. Freney; Rhys Harold Parry; Julian D. J. Sng; Ariel Isaacs; A. Khromykh; Guillermo Valenzuela Nieto; Alejandro Rojas-Fernandez; T. P. Davis; M. Prinz; B. Bengsch; V. Gladyshev; T. Woodruff; Jessica C Mar; D. Watterson; E. Wolvetang

Year: 2023

Venue: bioRxiv

DOI: https://doi.org/10.36948/ijfmr.2024.v06i03.22349

Paper Senolytics and Dietary Phytochemicals: Exploring Anti-Aging Strategies and Mechanisms in Aging and Disease

Edwin Dias; Darshak D Poojary · 2024 · International Journal For Multidisciplinary Research · DOI

Full title: Senolytics and Dietary Phytochemicals: Exploring Anti-Aging Strategies and Mechanisms in Aging and Disease

Authors: Edwin Dias; Darshak D Poojary

Year: 2024

Venue: International Journal For Multidisciplinary Research

Paper Senolytic Drugs: Implications for Clinical Practice

A. K. Ilyushchenko; L. Matchekhina; O. Tkacheva et al. · 2023 · Advances in Gerontology · DOI

Full title: Senolytic Drugs: Implications for Clinical Practice

Authors: A. K. Ilyushchenko; L. Matchekhina; O. Tkacheva; A. Balashova; A. A. Melnitskaia; A. Churov; I. Strazhesko

Year: 2023

Venue: Advances in Gerontology

DOI: https://doi.org/10.1134/s2079057024600186

Paper Quercetin- herbal bioactive nanotechnology for osteoarthritis & elderly health

Ghate, Utkarsh; Kulkarni, Hema · 2023 · Brazilian Journal of Development · DOI

Full title: Quercetin- herbal bioactive nanotechnology for osteoarthritis & elderly health

Authors: Ghate, Utkarsh; Kulkarni, Hema

Year: 2023

Venue: Brazilian Journal of Development

DOI: https://doi.org/10.34117/bjdv9n12-081

Paper Complexity of Inflammation in the Trajectory of Vascular Disease: Interleukin 6 and Beyond

Sano, Motoaki · 2023 · Annals of Vascular Diseases · DOI

Full title: Complexity of Inflammation in the Trajectory of Vascular Disease: Interleukin 6 and Beyond

Authors: Sano, Motoaki

Year: 2023

Venue: Annals of Vascular Diseases

DOI: https://doi.org/10.3400/avd.ra.23-00003

Paper PROTACs are effective in addressing the platelet toxicity associated with BCL-XL inhibitors

Zhang, Peiyi; Zhang, Xuan; Liu, Xingui et al. · 2020 · Exploration of Targeted Anti-tumor Therapy · DOI

Full title: PROTACs are effective in addressing the platelet toxicity associated with BCL-XL inhibitors

Authors: Zhang, Peiyi; Zhang, Xuan; Liu, Xingui; Khan, Sajid; Zhou, Daohong; Zheng, Guangrong

Year: 2020

Venue: Exploration of Targeted Anti-tumor Therapy

DOI: https://doi.org/10.37349/etat.2020.00017

Paper Clinical studies with drugs and biologics aimed at slowing or reversing normal aging processes—emerging results and future perspectives

Ricardo P. Garay · 2024 · Exploration of Drug Science · DOI

Full title: Clinical studies with drugs and biologics aimed at slowing or reversing normal aging processes—emerging results and future perspectives

Authors: Ricardo P. Garay

Year: 2024

Venue: Exploration of Drug Science

DOI: https://doi.org/10.37349/eds.2024.00040

Paper Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review)

T. Saliev; Prim B. Singh · 2025 · Biomedical Reports · DOI

Full title: Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review)

Authors: T. Saliev; Prim B. Singh

Year: 2025

Venue: Biomedical Reports

DOI: https://doi.org/10.3892/br.2025.1974

Paper Novel biological strategies to enhance the radiation therapeutic ratio

Kim, Jae Ho; Jenrow, Kenneth A.; Brown, Stephen L. · 2018 · Radiation Oncology Journal · DOI

Full title: Novel biological strategies to enhance the radiation therapeutic ratio

Authors: Kim, Jae Ho; Jenrow, Kenneth A.; Brown, Stephen L.

Year: 2018

Venue: Radiation Oncology Journal

DOI: https://doi.org/10.3857/roj.2018.00332

Paper Cancer‑associated fibroblasts under therapy‑induced senescence in the tumor microenvironment (Review)

Qiu-Yu Zhang; Yijie Lou; Hao Fang et al. · 2024 · Experimental and Therapeutic Medicine · DOI

Full title: Cancer‑associated fibroblasts under therapy‑induced senescence in the tumor microenvironment (Review)

Authors: Qiu-Yu Zhang; Yijie Lou; Hao Fang; Shao-Cong Sun; Rijuan Jin; Yunxi Ji; Zhe Chen

Year: 2024

Venue: Experimental and Therapeutic Medicine

DOI: https://doi.org/10.3892/etm.2024.12438

Paper Targeting senescent cells and tumor therapy (Review)

Wang, Zehua; Gao, Jianwen; Liu, Haiou et al. · 2020 · International Journal of Molecular Medicine · DOI

Full title: Targeting senescent cells and tumor therapy (Review)

Authors: Wang, Zehua; Gao, Jianwen; Liu, Haiou; Ohno, Yuko; Xu, Congjian

Year: 2020

Venue: International Journal of Molecular Medicine

DOI: https://doi.org/10.3892/ijmm.2020.4705

Paper Mechanism and significance of cell senescence induced by viral infection

Chang, Yunchuang; Wu, Xinna; Deng, Lingli et al. · 2025 · Journal of Zhejiang University (Medical Sciences) · DOI

Full title: Mechanism and significance of cell senescence induced by viral infection

Authors: Chang, Yunchuang; Wu, Xinna; Deng, Lingli; Wang, Sanying; Mao, Genxiang

Year: 2025

Venue: Journal of Zhejiang University (Medical Sciences)

DOI: https://doi.org/10.3724/zdxbyxb-2024-0213

Paper Senescent hepatic stellate cells drive inflammation and disease progression in MASH (Review).

Han, Zhiqi; She, Yiran; Wu, Di et al. · 2026 · Experimental and therapeutic medicine · DOI

Full title: Senescent hepatic stellate cells drive inflammation and disease progression in MASH (Review).

Authors: Han, Zhiqi; She, Yiran; Wu, Di; Zhang, Nuo; Liu, Zheyuan; Wang, Zhongyuan; Zhou, Xiaoying; Li, Shuo

Year: 2026

Venue: Experimental and therapeutic medicine

DOI: https://doi.org/10.3892/etm.2026.13090

Paper Ageing microenvironment mediates lymphocyte carcinogenesis and lymphoma drug resistance: From mechanisms to clinical therapy (Review).

Zhang, Yue; Chu, Jingwen; Hou, Qi et al. · 2024 · International journal of oncology · DOI

Full title: Ageing microenvironment mediates lymphocyte carcinogenesis and lymphoma drug resistance: From mechanisms to clinical therapy (Review).

Authors: Zhang, Yue; Chu, Jingwen; Hou, Qi; Qian, Siyu; Wang, Zeyuan; Yang, Qing; Song, Wenting; Dong, Ling; Shi, Zhuangzhuang; Gao, Yuyang; Meng, Miaomiao; Zhang, Mingzhi; Zhang, Xudong; Chen, Qingjiang

Year: 2024

Venue: International journal of oncology

DOI: https://doi.org/10.3892/ijo.2024.5653

Paper Alternative splicing of BCL‑X and implications for treating hematological malignancies (Review)

Chen, Wanling; Li, Jinggang · 2021 · Oncology Letters · DOI

Full title: Alternative splicing of BCL‑X and implications for treating hematological malignancies (Review)

Authors: Chen, Wanling; Li, Jinggang

Year: 2021

Venue: Oncology Letters

DOI: https://doi.org/10.3892/ol.2021.12931

Paper Cellular senescence in cancer: Unveiling dual roles, tumor microenvironment dynamics and therapeutic innovations (Review).

Lam, Yatsu; Gu, Jiaming; Yin, Peihao · 2025 · Oncology letters · DOI

Full title: Cellular senescence in cancer: Unveiling dual roles, tumor microenvironment dynamics and therapeutic innovations (Review).

Authors: Lam, Yatsu; Gu, Jiaming; Yin, Peihao

Year: 2025

Venue: Oncology letters

DOI: https://doi.org/10.3892/ol.2025.15338

Paper Epigenetic Signatures of Aging: A Comprehensive Study of Biomarker Discovery

Lee, Min Seob; Kwon, Hyuk Jung; Kim, Yonjung et al. · 2023 · Advances in Aging Research · DOI

Full title: Epigenetic Signatures of Aging: A Comprehensive Study of Biomarker Discovery

Authors: Lee, Min Seob; Kwon, Hyuk Jung; Kim, Yonjung; Min, Na Young; Lee, So Young; Lee, Isaac Kise

Year: 2023

Venue: Advances in Aging Research

DOI: https://doi.org/10.4236/aar.2023.122002

Paper Quercetin attenuates the symptoms of osteoarthritis in vitro and in vivo by suppressing ferroptosis via activation of AMPK/Nrf2/Gpx4 signaling

Dong, Shiyu; Li, Xiaoliang; Xu, Genrong et al. · 2024 · Molecular Medicine Reports · DOI

Full title: Quercetin attenuates the symptoms of osteoarthritis in vitro and in vivo by suppressing ferroptosis via activation of AMPK/Nrf2/Gpx4 signaling

Authors: Dong, Shiyu; Li, Xiaoliang; Xu, Genrong; Chen, Liming; Zhao, Jiyang

Year: 2024

Venue: Molecular Medicine Reports

DOI: https://doi.org/10.3892/mmr.2024.13425

Paper - **DOI:** 10.51584/ijrias.2025.10050020 - **Authors:** Emmanuel Olanrewaju Adebayo, Blessing Adeola Fadola, Oluwadayomi Adedeji, Imoleayo Moses Olorunyolemi - **Year:** 2025 - **Journal:** International journal of research and innovation in applied science

Emmanuel Olanrewaju Adebayo; Blessing Adeola Fadola; Oluwadayomi Adedeji et al. · 2025 · International journal of research and innovation in applied science · DOI

Full title: - **DOI:** 10.51584/ijrias.2025.10050020 - **Authors:** Emmanuel Olanrewaju Adebayo, Blessing Adeola Fadola, Oluwadayomi Adedeji, Imoleayo Moses Olorunyolemi - **Year:** 2025 - **Journal:** International journal of research and innovation in applied science

Authors: Emmanuel Olanrewaju Adebayo; Blessing Adeola Fadola; Oluwadayomi Adedeji; Imoleayo Moses Olorunyolemi

Year: 2025

Venue: International journal of research and innovation in applied science

DOI: https://doi.org/10.51584/ijrias.2025.10050020

Paper The Aging of Cells: Cellular Senescence and Implications for Age-Related Diseases

Andrew Kim; Jounghyun Yoo · 2023 · Journal of student-scientists' research · DOI

Full title: The Aging of Cells: Cellular Senescence and Implications for Age-Related Diseases

Authors: Andrew Kim; Jounghyun Yoo

Year: 2023

Venue: Journal of student-scientists' research

DOI: https://doi.org/10.47611/jsrhs.v12i3.4847

Paper Exploring the Role of Senescent Cells in Neurodegenerative Pathology: A Window Into Promising Therapeutic Avenues

Gabriela Bentolila; Niharika Agrawal; Julie Phung et al. · 2024 · Berkeley Pharma Tech Journal of Medicine · DOI

Full title: Exploring the Role of Senescent Cells in Neurodegenerative Pathology: A Window Into Promising Therapeutic Avenues

Authors: Gabriela Bentolila; Niharika Agrawal; Julie Phung; Linh Van; Gatik Trivedi

Year: 2024

Venue: Berkeley Pharma Tech Journal of Medicine

DOI: https://doi.org/10.52243/bptjm.v4i2.71

Paper Olea europaea L. Leaf Extract Attenuates Temozolomide-Induced Senescence-Associated Secretion Phenotype in Glioblastoma.

M. Erçelik; B. Tunca; Seçil Ak Aksoy et al. · 2022 · Turkish Journal of Pharmaceutical Sciences · DOI

Full title: Olea europaea L. Leaf Extract Attenuates Temozolomide-Induced Senescence-Associated Secretion Phenotype in Glioblastoma.

Authors: M. Erçelik; B. Tunca; Seçil Ak Aksoy; Ç. Tekin; G. Tezcan

Year: 2022

Venue: Turkish Journal of Pharmaceutical Sciences

DOI: https://doi.org/10.4274/tjps.galenos.2022.57639

Paper Protective Mechanisms of Quercetin in Various Lung-induced Injuries

Rizky, Wahyu Choirur; Jihwaprani, Muhammad Candragupta; Mushtaq, Mazhar · 2022 · SCIREA Journal of Clinical Medicine · DOI

Full title: Protective Mechanisms of Quercetin in Various Lung-induced Injuries

Authors: Rizky, Wahyu Choirur; Jihwaprani, Muhammad Candragupta; Mushtaq, Mazhar

Year: 2022

Venue: SCIREA Journal of Clinical Medicine

DOI: https://doi.org/10.54647/cm32844

Paper Quercetin effect on endogenous factors of cardiovascular risk and ageing biomarkers in elderly people

Shatilo, Valeri; Antonyuk-Shcheglova, Ivanna; Наскалова, Світлана et al. · 2022 · Ageing & Longevity · DOI

Full title: Quercetin effect on endogenous factors of cardiovascular risk and ageing biomarkers in elderly people

Authors: Shatilo, Valeri; Antonyuk-Shcheglova, Ivanna; Наскалова, Світлана; Bondarenko, Olena; Hrib, Oksana; Krasnienkov, Dmitry; Pisaruk, Anatoly

Year: 2022

Venue: Ageing & Longevity

DOI: https://doi.org/10.47855/10.47855/jal9020-2022-2-1

Paper Targeting the Senescent Tumor Microenvironment to Sensitize Immunotherapy

Wen Sun · 2025 · Highlights in Science Engineering and Technology · DOI

Full title: Targeting the Senescent Tumor Microenvironment to Sensitize Immunotherapy

Authors: Wen Sun

Year: 2025

Venue: Highlights in Science Engineering and Technology

DOI: https://doi.org/10.54097/te6m0d54

Paper Cellular senescence in bone.

J. Farr; S. Khosla · 2019 · Bone · DOI

Full title: Cellular senescence in bone.

Authors: J. Farr; S. Khosla

Year: 2019

Venue: Bone

DOI: https://doi.org/10.1016/j.bone.2019.01.015

Paper Exploring a Novel Approach to Senolysis Using a Urokinase Plasminogen Activator Receptor-targeting Antibody-Drug Conjugate

Zijian Wei · 2025 · Theoretical and Natural Science · DOI

Full title: Exploring a Novel Approach to Senolysis Using a Urokinase Plasminogen Activator Receptor-targeting Antibody-Drug Conjugate

Authors: Zijian Wei

Year: 2025

Venue: Theoretical and Natural Science

DOI: https://doi.org/10.54254/2753-8818/2025.au27557

Paper The Dual Role of Cellular Senescence in Cervical Cancer

Xinning Tong · 2025 · Advances in Engineering Technology Research · DOI

Full title: The Dual Role of Cellular Senescence in Cervical Cancer

Authors: Xinning Tong

Year: 2025

Venue: Advances in Engineering Technology Research

DOI: https://doi.org/10.56028/aetr.15.1.1073.2025

Paper INFLAMMAGING IN MUSCLE: THE MISSING LINK BETWEEN SARCOPENIA AND IDIOPATHIC INFLAMMATORY MYOPATHIES

Jagtap, Kshitij; Hoff, Leonardo Santos; Conticini, Edoardo et al. · 2022 · Anti-Aging Eastern Europe · DOI

Full title: INFLAMMAGING IN MUSCLE: THE MISSING LINK BETWEEN SARCOPENIA AND IDIOPATHIC INFLAMMATORY MYOPATHIES

Authors: Jagtap, Kshitij; Hoff, Leonardo Santos; Conticini, Edoardo; Naveen, R; Gupta, Latika

Year: 2022

Venue: Anti-Aging Eastern Europe

DOI: https://doi.org/10.56543/aaeeu.2022.1.1.10

Paper Interventional Strategies to Delay Aging-Related Dysfunctions of the Musculoskeletal System

N. Fukase; I. Stake; Y. Murata et al. · 2021 · DOI

Full title: Interventional Strategies to Delay Aging-Related Dysfunctions of the Musculoskeletal System

Authors: N. Fukase; I. Stake; Y. Murata; W. S. Hambright; S. Ravuri; M. Philippon; J. Huard

Year: 2021

DOI: https://doi.org/10.5772/intechopen.97311

Paper Mild Uncoupling of Mitochondria Synergistically Enhances Senolytic Specificity and Sensitivity of BH3 Mimetics

Miwa, Satomi; Fielder, Edward; Ishaq, Abbas et al. · 2024 · DOI

Full title: Mild Uncoupling of Mitochondria Synergistically Enhances Senolytic Specificity and Sensitivity of BH3 Mimetics

Authors: Miwa, Satomi; Fielder, Edward; Ishaq, Abbas; Low, Evon; Laws, Joseph; Calista, Aisha; Castle, Jemma; Zglinicki, Thomas von

Year: 2024

DOI: https://doi.org/10.59368/agingbio.20240022

Paper Damage-Induced Senescent Immune Cells Regulate Regeneration of the Zebrafish Retina

Gregory J. Konar; Z. Flickinger; Shivani Sharma et al. · 2024 · Aging biology · DOI

Full title: Damage-Induced Senescent Immune Cells Regulate Regeneration of the Zebrafish Retina

Authors: Gregory J. Konar; Z. Flickinger; Shivani Sharma; Kyle T. Vallone; Charles E. Lyon; Claire Doshier; Audrey L. Lingan; William Lyon; James G. Patton

Year: 2024

Venue: Aging biology

Paper Translational longevity medicine: a Swiss perspective in an ageing country

Ruckstuhl, Marco M.; Bischof, Evelyne; Blatch, Dana et al. · 2023 · Swiss Medical Weekly · DOI

Full title: Translational longevity medicine: a Swiss perspective in an ageing country

Authors: Ruckstuhl, Marco M.; Bischof, Evelyne; Blatch, Dana; Buhayer, Aliki; Goldhahn, Jörg; Battegay, Edouard; Tichelli, André; Ewald, Collin Y.

Year: 2023

Venue: Swiss Medical Weekly

DOI: https://doi.org/10.57187/smw.2023.40088

Paper Senescence and Beyond: Exploring Senolytic Strategies for Chronic Disease

Mansi Srivastava; Samatha Ampeti; Raziya Begum Sheikh et al. · 2025 · medtigo Journal of Pharmacology · DOI

Full title: Senescence and Beyond: Exploring Senolytic Strategies for Chronic Disease

Authors: Mansi Srivastava; Samatha Ampeti; Raziya Begum Sheikh; Patel Nirali Kirankumar; Shubham Ravindra Sali

Year: 2025

Venue: medtigo Journal of Pharmacology

DOI: https://doi.org/10.63096/medtigo30612313

Paper Subtype-Specific SASP Dynamics Predict Mesenchymal Transition in Recurrent Glioblastoma

Varshith Kotagiri; Ava Teng · 2026 · bioRxiv · DOI

Full title: Subtype-Specific SASP Dynamics Predict Mesenchymal Transition in Recurrent Glioblastoma

Authors: Varshith Kotagiri; Ava Teng

Year: 2026

Venue: bioRxiv

DOI: https://doi.org/10.64898/2026.01.15.699753

Paper Single Cell Transcriptomics Reveals Global Markers of Transcriptional Diversity Across Different Forms of Cellular Senescence

Shane A. Evans; Yee Voan Teo; K. Clark et al. · 2021 · bioRxiv · DOI

Full title: Single Cell Transcriptomics Reveals Global Markers of Transcriptional Diversity Across Different Forms of Cellular Senescence

Authors: Shane A. Evans; Yee Voan Teo; K. Clark; Takahiro Ito; J. Sedivy; N. Neretti

Year: 2021

Venue: bioRxiv

Paper Biology of Stress Responses in Aging

Maragkakis, Manolis; Ferrucci, Luigi; Gorospe, Myriam et al. · 2023 · DOI

Full title: Biology of Stress Responses in Aging

Authors: Maragkakis, Manolis; Ferrucci, Luigi; Gorospe, Myriam; Malla, Sulochan; Hatzoglou, Maria; Trifunović, Aleksandra; Glick, Adam B.; Finkel, Toren; Longo, Valter D.; Kaushik, Susmita; Muñoz‐Cánoves, Pura; Lithgow, Gordon J.; Naidoo, Nirinjini; Booth, Lauren N.; Payea, Matthew J.; Herman, Allison B.; Cabo, Rafael de; Wilson, David M.

Year: 2023

DOI: https://doi.org/10.59368/agingbio.20230001

Paper Pharmacology of Senolytics: Targeting Cellular Aging in Chronic Diseases

Priyanka R.Chaudhari · 2025 · International Journal of Sciences and Innovation Engineering · DOI

Full title: Pharmacology of Senolytics: Targeting Cellular Aging in Chronic Diseases

Authors: Priyanka R.Chaudhari

Year: 2025

Venue: International Journal of Sciences and Innovation Engineering

DOI: https://doi.org/10.70849/ijsci02092025077

Paper Standard treatment against paediatric BRAF-V600E glioma promotes senescence and sensitizes tumours to BCL-xL inhibition

Romain Guiho; Hiba Hamdi; Grace Cooksley et al. · 2026 · bioRxiv · DOI

Full title: Standard treatment against paediatric BRAF-V600E glioma promotes senescence and sensitizes tumours to BCL-xL inhibition

Authors: Romain Guiho; Hiba Hamdi; Grace Cooksley; Timoty H. Chang; Lei Cao; Romain Sigaud; Ashley Vardon; S. Haston; F. Selt; A. Bassey; Daniela Kocher; Daniel Gharai; Jesús Gil; Olaf Witt; T. Milde; Darren Hargrave; P. Bandopadhayay; Paula Alexandre; J. P. M. Barbera

Year: 2026

Venue: bioRxiv

DOI: https://doi.org/10.64898/2026.01.13.698644

Paper “BAP1 Loss Induces Senescence and Enhances the Response to Radiation Therapy and Senolytics”

Abdelrahman M. Elsayed; Asmaa Mosbeh; Esraa G. Eltasawi et al. · 2026 · bioRxiv · DOI

Full title: “BAP1 Loss Induces Senescence and Enhances the Response to Radiation Therapy and Senolytics”

Authors: Abdelrahman M. Elsayed; Asmaa Mosbeh; Esraa G. Eltasawi; Pranita Hanpude; Md Nasir Uddin; C. M. Cebulla; M. H. Abdel-Rahman

Year: 2026

Venue: bioRxiv

DOI: https://doi.org/10.64898/2026.02.05.704104

Paper The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases

Qixia Xu; Gaoxiang Li; Hongwei Zhang et al. · 2025 · bioRxiv · DOI

Full title: The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases

Authors: Qixia Xu; Gaoxiang Li; Hongwei Zhang; Zhirui Jiang; Xiuxia Gao; Zi Li; Larissa G P Langhi Prata; James L. Kirkland; Guilong Zhang; Yu Sun

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.64898/2025.12.25.696450

Paper Senescence-Associated Secretory Phenotype (SASP) in Diabetes

· 2025 · Journal of Pharma Insights and Research · DOI

Full title: Senescence-Associated Secretory Phenotype (SASP) in Diabetes

Year: 2025

Venue: Journal of Pharma Insights and Research

DOI: https://doi.org/10.69613/qjzz6g14

Paper Dasatinib regulates the proliferation and osteogenic differentiation of PDLSCs through Erk and EID3 signals

Jia, Linglu; Zhang, Yafei; Sun, Shaoqing et al. · 2023 · International Journal of Medical Sciences · DOI

Full title: Dasatinib regulates the proliferation and osteogenic differentiation of PDLSCs through Erk and EID3 signals

Authors: Jia, Linglu; Zhang, Yafei; Sun, Shaoqing; Hao, Xingyao; Wen, Yong

Year: 2023

Venue: International Journal of Medical Sciences

DOI: https://doi.org/10.7150/ijms.87089

Paper Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and Fibrosis via Oxidative Stress, DNA Damage, and p53/TGFβ1-Induced Epithelial-Mesenchymal Transition

Lü, Jinhong; Sun, Weiwei; Liu, Boyang et al. · 2024 · International Journal of Biological Sciences · DOI

Full title: Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and Fibrosis via Oxidative Stress, DNA Damage, and p53/TGFβ1-Induced Epithelial-Mesenchymal Transition

Authors: Lü, Jinhong; Sun, Weiwei; Liu, Boyang; Zhang, Jinge; Wang, Rong; Goltzman, David; Miao, Dengshun

Year: 2024

Venue: International Journal of Biological Sciences

DOI: https://doi.org/10.7150/ijbs.93598

Paper The Roles of Myeloid Cells in Aging-related Liver Diseases

Yao, Jinghao; Li, Yang; Wang, Hua · 2023 · International Journal of Biological Sciences · DOI

Full title: The Roles of Myeloid Cells in Aging-related Liver Diseases

Authors: Yao, Jinghao; Li, Yang; Wang, Hua

Year: 2023

Venue: International Journal of Biological Sciences

DOI: https://doi.org/10.7150/ijbs.82352

Paper Clearance of senescent cells enhances skin wound healing in type 2 diabetic mice

P. N. Samarawickrama; Guiqin Zhang; Enfang Zhu et al. · 2024 · Theranostics · DOI

Full title: Clearance of senescent cells enhances skin wound healing in type 2 diabetic mice

Authors: P. N. Samarawickrama; Guiqin Zhang; Enfang Zhu; Xin Dong; Ayesha Nisar; Hong Zhu; Yuan Ma; Zheyan Zhou; Honglin Yang; Li Gui; Mei Cao; Wei Li; Yu Chang; Meiting Zi; Haoling Cui; Zhongping Duan; Xuan Zhang; Wen Li; Yonghan He

Year: 2024

Venue: Theranostics

DOI: https://doi.org/10.7150/thno.100991

Paper Targeted elimination of senescent cells by engineered extracellular vesicles attenuates atherosclerosis in ApoE-/- mice with minimal side effects.

Zhang, Liang; Wang, Chen; Hu, Wei et al. · 2023 · Theranostics · DOI

Full title: Targeted elimination of senescent cells by engineered extracellular vesicles attenuates atherosclerosis in ApoE-/- mice with minimal side effects.

Authors: Zhang, Liang; Wang, Chen; Hu, Wei; Bu, Te; Sun, Wenqi; Zhou, Tian; Qiu, Shuo; Wei, Mengying; Xing, Helin; Li, Zhelong; Yang, Guodong; Yuan, Lijun

Year: 2023

Venue: Theranostics

DOI: https://doi.org/10.7150/thno.87484

Paper Ability of Local Clearance of Senescent Cells in Ipsilateral Hemisphere to Mitigate Acute Ischemic Brain Injury in Mice

Kuan-Jung Lu; J. Sheu; Ruei-Dun Teng et al. · 2023 · International Journal on Biological Sciences · DOI

Full title: Ability of Local Clearance of Senescent Cells in Ipsilateral Hemisphere to Mitigate Acute Ischemic Brain Injury in Mice

Authors: Kuan-Jung Lu; J. Sheu; Ruei-Dun Teng; Tanasekar Jayakumar; C. Chung; Cheng-Ying Hsieh

Year: 2023

Venue: International Journal on Biological Sciences

DOI: https://doi.org/10.7150/ijbs.84060

Paper Clearance of senescent cells during cardiac ischemia-reperfusion injury improves heart recovery following myocardial infarction

Emily Dookun; R. Redgrave; Simon Tual-Chalot et al. · 2020 · DOI

Full title: Clearance of senescent cells during cardiac ischemia-reperfusion injury improves heart recovery following myocardial infarction

Authors: Emily Dookun; R. Redgrave; Simon Tual-Chalot; Averina Suwana; James Chapman; Leticia Donastorg; Eleanor Gill; O. Yausep; Y. Santin; J. Mialet-Perez; Andrew W. Owens; I. Spyridopoulos; M. Taggart; G. Richardson

Year: 2020

DOI: https://doi.org/10.1101/2020.04.28.065789

Paper Artificial intelligence based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer’s disease

Tsuji, Shingo; Hase, Takeshi; Yachie‐Kinoshita, Ayako et al. · 2020 · DOI

Full title: Artificial intelligence based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer’s disease

Authors: Tsuji, Shingo; Hase, Takeshi; Yachie‐Kinoshita, Ayako; Nishino, Taiko; Ghosh, Samik; Kikuchi, Masataka; Shimokawa, Kazuro; Aburatani, Hiroyuki; Kitano, Hiroaki; Tanaka, Hiroshi

Year: 2020

DOI: https://doi.org/10.1101/2020.07.17.208116

Paper Aryl hydrocarbon receptor blocks aging-induced senescence in the liver and fibroblast cells.

Nacarino-Palma, Ana; Rico-Leo, Eva M; Campisi, Judith et al. · 2022 · Aging · DOI

Full title: Aryl hydrocarbon receptor blocks aging-induced senescence in the liver and fibroblast cells.

Year: 2022

Venue: Aging

Paper Therapy-induced normal tissue damage promotes breast cancer metastasis

Perkins, Douglas W.; Steiner, Ivana; Haider, Syed Waqar et al. · 2020 · DOI

Full title: Therapy-induced normal tissue damage promotes breast cancer metastasis

Authors: Perkins, Douglas W.; Steiner, Ivana; Haider, Syed Waqar; Robertson, David; Buus, Richard; O’Leary, Lynda; Isacke, Clare M.

Year: 2020

DOI: https://doi.org/10.1101/2020.10.17.343590

Paper Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung

Nabora Reyes de Mochel; Ka Neng Cheong; Monica Cassandras et al. · 2020 · bioRxiv · DOI

Full title: Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung

Authors: Nabora Reyes de Mochel; Ka Neng Cheong; Monica Cassandras; Chaoqun Wang; M. Krasilnikov; Peri Matatia; Ari B. Molofsky; J. Campisi; Tien Peng

Year: 2020

Venue: bioRxiv

DOI: https://doi.org/10.1101/2020.06.10.142893

Paper Selective Vulnerability of Senescent Glioblastoma Cells to Bcl-XL Inhibition

Rahman, Masum; Olson, Ian; Mansour, Moustafa et al. · 2020 · DOI

Full title: Selective Vulnerability of Senescent Glioblastoma Cells to Bcl-XL Inhibition

Authors: Rahman, Masum; Olson, Ian; Mansour, Moustafa; Carlstrom, Lucas P.; Sutiwisesak, Rujapope; Saber, Rehan; Rajani, Karishma; Warrington, Arthur E.; Howard, A. B.; Schroeder, Mark A.; Chen, Sisi; Decker, Paul A.; Sananikone, Eliot F.; Zhu, Yi; Parney, Ian F.; Burma, Sandeep; Brown, Desmond; Rodriguez, Moses; Sarkaria, Jann N.; Kirkland, James L.; Burns, Terry C.

Year: 2020

DOI: https://doi.org/10.1101/2020.06.03.132712

Paper Rapamycin microparticles induce autophagy, prevent senescence and are effective in treatment of Osteoarthritis

Dhanabalan, Kaamini M.; Dravid, Ameya A.; Agarwal, Smriti et al. · 2021 · DOI

Full title: Rapamycin microparticles induce autophagy, prevent senescence and are effective in treatment of Osteoarthritis

Authors: Dhanabalan, Kaamini M.; Dravid, Ameya A.; Agarwal, Smriti; Sharath, Ramanath K.; Padmanabhan, Ashok Kumar; Agarwal, Rachit

Year: 2021

DOI: https://doi.org/10.1101/2021.07.20.453073

Paper Modulation of fracture healing by the transient accumulation of senescent cells

D. Saul; D. Monroe; Jennifer L. Rowsey et al. · 2021 · bioRxiv · DOI

Full title: Modulation of fracture healing by the transient accumulation of senescent cells

Authors: D. Saul; D. Monroe; Jennifer L. Rowsey; R. L. Kosinsky; S. Vos; Madison L. Doolittle; J. Farr; S. Khosla

Year: 2021

Venue: bioRxiv

DOI: https://doi.org/10.1101/2021.05.18.444618

Paper Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

Rawlings, Thomas M.; Makwana, Komal; Taylor, Deborah M. et al. · 2021 · DOI

Full title: Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

Authors: Rawlings, Thomas M.; Makwana, Komal; Taylor, Deborah M.; Molè, Matteo A.; Fishwick, Katherine; Tryfonos, Maria; Odendaal, Joshua; Hawkes, Amelia; Zernicka‐Goetz, Magdalena; Hartshorne, Geraldine; Brosens, Jan J.; Lucas, Emma S.

Year: 2021

DOI: https://doi.org/10.1101/2021.03.02.433560

Paper Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

O’Sullivan, Eoin; Mylonas, Katie J.; Bell, Rachel et al. · 2022 · JCI Insight · DOI

Full title: Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

Year: 2022

Venue: JCI Insight

Paper Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

Fielder, Edward; Wan, Tengfei; Alimohammadiha, Ghazaleh et al. · 2021 · DOI

Full title: Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

Authors: Fielder, Edward; Wan, Tengfei; Alimohammadiha, Ghazaleh; Ishaq, Abbas; Low, Evon; Weigand, Bettina M.; Kelly, George; Parker, Craig; Griffin, Brigid; Jurk, Diana; Korolchuk, Viktor I.; Zglinicki, Thomas von; Miwa, Satomi

Year: 2021

DOI: https://doi.org/10.1101/2021.12.15.472756

Paper Clearance of defective muscle stem cells by senolytics reduces the expression of senescence-associated secretory phenotype and restores myogenesis in myotonic dystrophy type 1

Talita C. Conte; Gilberto Duran-Bishop; Zakaria Orfi et al. · 2022 · bioRxiv · DOI

Full title: Clearance of defective muscle stem cells by senolytics reduces the expression of senescence-associated secretory phenotype and restores myogenesis in myotonic dystrophy type 1

Authors: Talita C. Conte; Gilberto Duran-Bishop; Zakaria Orfi; Inès Mokhtari; A. Deprez; M. Roussel; I. Côté; O. Pellerito; D. Maggiorani; B. Benabdallah; S. Leclerc; Lara Feulner; J. Mathieu; C. Gagnon; G. Andelfinger; C. Beauséjour; S. McGraw; É. Duchesne; Nicolas A. Dumont

Year: 2022

Venue: bioRxiv

DOI: https://doi.org/10.1101/2022.06.22.497227

Paper Fisetin Attenuates Cellular Senescence Accumulation During Culture Expansion of Human Adipose-Derived Stem Cells.

Mullen, Michael; Nelson, Anna Laura; Goff, Alexander et al. · 2023 · Stem cells (Dayton, Ohio) · DOI

Full title: Fisetin Attenuates Cellular Senescence Accumulation During Culture Expansion of Human Adipose-Derived Stem Cells.

Authors: Mullen, Michael; Nelson, Anna Laura; Goff, Alexander; Billings, Jake; Kloser, Heidi; Huard, Charles; Mitchell, John; Hambright, William Sealy; Ravuri, Sudheer; Huard, Johnny

Year: 2023

Venue: Stem cells (Dayton, Ohio)

DOI: https://doi.org/10.1093/stmcls/sxad036

Paper Dexamethasone induces senescence of lung epithelial cells and augments TGF-β1-mediated production of the fibrosis mediator serpin E1 (plasminogen activator inhibitor-1)

Longhorne, Francesca. L.; Wilkinson, Holly N.; Hardman, Matthew J. et al. · 2021 · DOI

Full title: Dexamethasone induces senescence of lung epithelial cells and augments TGF-β1-mediated production of the fibrosis mediator serpin E1 (plasminogen activator inhibitor-1)

Authors: Longhorne, Francesca. L.; Wilkinson, Holly N.; Hardman, Matthew J.; Hart, Simon P.

Year: 2021

DOI: https://doi.org/10.1101/2021.11.29.470337

Paper In the pursuit of longevity: anti-aging substances, nanotechnological preparations, and emerging approaches

Giannouli, Elena; Karalis, Vangelis · 2022 · DOI

Full title: In the pursuit of longevity: anti-aging substances, nanotechnological preparations, and emerging approaches

Authors: Giannouli, Elena; Karalis, Vangelis

Year: 2022

DOI: https://doi.org/10.1101/2022.03.20.22272670

Paper Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

Meiners, Franziska; Hinz, Burkhard; Boeckmann, Lars et al. · 2024 · Scientific Reports · DOI

Full title: Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

Authors: Meiners, Franziska; Hinz, Burkhard; Boeckmann, Lars; Secci, Riccardo; Sueto, Salem Oduro Beffi; Kuepfer, Lars; Fuellen, Georg; Barrantes, Israel

Year: 2024

Venue: Scientific Reports

Paper Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma

Salam, Rana; Saliou, Alexa; Bielle, Franck et al. · 2023 · Nature Communications · DOI

Full title: Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma

Authors: Salam, Rana; Saliou, Alexa; Bielle, Franck; Bertrand, Mathilde; Antoniewski, Christophe; Carpentier, Alain; Alentorn, Agustí; Capelle, Laurent; Sanson, Marc; Huillard, Emmanuelle; Bellenger, Léa; Guégan, Justine; Roux, Isabelle Le

Year: 2023

Venue: Nature Communications

Paper Cellular senescence preserves viral genome maintenance

A. M. Pham; Luz E. Ortiz; A. Lukacher et al. · 2022 · bioRxiv · DOI

Full title: Cellular senescence preserves viral genome maintenance

Authors: A. M. Pham; Luz E. Ortiz; A. Lukacher; H. Kwun

Year: 2022

Venue: bioRxiv

DOI: https://doi.org/10.1101/2022.07.12.499783

Paper Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

Madison L. Doolittle; D. Saul; J. Kaur et al. · 2023 · bioRxiv · DOI

Full title: Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

Authors: Madison L. Doolittle; D. Saul; J. Kaur; Jennifer L. Rowsey; Stephanie J. Vos; K. Pavelko; J. Farr; D. Monroe; S. Khosla

Year: 2023

Venue: bioRxiv

DOI: https://doi.org/10.1101/2023.01.12.523760

Paper Therapy Induced Tumor Senescence Model

Ghanendra Singh · 2022 · bioRxiv · DOI

Full title: Therapy Induced Tumor Senescence Model

Authors: Ghanendra Singh

Year: 2022

Venue: bioRxiv

DOI: https://doi.org/10.1101/2022.10.23.513380

Paper High-dose Polyphenol-rich Nutrition Improves Lipid and Inflammation Profiles and Triggers Apoptotic Signaling in Healthy Elderly People (the ErdBEHR Study)

Hartmann, Alexander; Secci, Riccardo; Mensch, Juliane et al. · 2023 · DOI

Full title: High-dose Polyphenol-rich Nutrition Improves Lipid and Inflammation Profiles and Triggers Apoptotic Signaling in Healthy Elderly People (the ErdBEHR Study)

Authors: Hartmann, Alexander; Secci, Riccardo; Mensch, Juliane; Jäger, Kathrin; Steinhagen‐Thiessen, Elisabeth; Barrantes, Israel; Palmer, Daniel H.; Kowald, Axel; Schwarz, Rico; Hinz, Burkhard; Weber, Daniela; Grune, Tilman; Hübbe, Patricia; Rimbach, Gerald; Rudolf, Henrik; Walter, Michael; Fuellen, Georg

Year: 2023

DOI: https://doi.org/10.1101/2023.04.03.23287994

Paper Damage-Induced Senescent Immune Cells Regulate Regeneration of the Zebrafish Retina

Gregory J. Konar; Z. Flickinger; Shivani Sharma et al. · 2024 · Aging biology · DOI

Full title: Damage-Induced Senescent Immune Cells Regulate Regeneration of the Zebrafish Retina

Authors: Gregory J. Konar; Z. Flickinger; Shivani Sharma; Kyle T. Vallone; Charles E. Lyon; Claire Doshier; Audrey L. Lingan; William Lyon; James G. Patton

Year: 2024

Venue: Aging biology

Paper Quercetin, a senolytic, enhances endometrial stromal cell decidualization through AKT and p53 signaling and reveals the potential role of senescent stromal cells in endometriosis

Julia Delenko; Xiangying Xue; Prodyot K. Chatterjee et al. · 2023 · medRxiv · DOI

Full title: Quercetin, a senolytic, enhances endometrial stromal cell decidualization through AKT and p53 signaling and reveals the potential role of senescent stromal cells in endometriosis

Authors: Julia Delenko; Xiangying Xue; Prodyot K. Chatterjee; Nathaniel Hyman; Andrew J Shih; Robert P. Adelson; Polona Safaric-Tepes; P. Gregersen; Christine N Metz

Year: 2023

Venue: medRxiv

DOI: https://doi.org/10.1101/2023.08.30.23294800

Paper Treatment of advanced atherosclerotic mice with the senolytic agent ABT-263 is associated with reduced indices of plaque stability and increased mortality

Karnewar, Santosh; Karnewar, Vaishnavi; Shankman, Laura S. et al. · 2023 · DOI

Full title: Treatment of advanced atherosclerotic mice with the senolytic agent ABT-263 is associated with reduced indices of plaque stability and increased mortality

Authors: Karnewar, Santosh; Karnewar, Vaishnavi; Shankman, Laura S.; Owens, Gary K.

Year: 2023

DOI: https://doi.org/10.1101/2023.07.12.548696

Paper TRAIL pathway suppression of cancer cell growth and immune cell-mediated tumor cell-killing in a senescent fibroblast-constructed tumor microenvironment

Shengliang Zhang; K. Huntington; Lanlan Zhou et al. · 2023 · bioRxiv · DOI

Full title: TRAIL pathway suppression of cancer cell growth and immune cell-mediated tumor cell-killing in a senescent fibroblast-constructed tumor microenvironment

Authors: Shengliang Zhang; K. Huntington; Lanlan Zhou; A. Seyhan; Bianca Kun; B. Carneiro; J. Kreiling; J. M. Sedivy; Wafik S. El-Deiry

Year: 2023

Venue: bioRxiv

DOI: https://doi.org/10.1101/2023.11.30.569479

Paper Vutiglabridin Alleviates Cellular Senescence Process of Dysfunctional Replication, Metabolic Regulation, and Circadian Clock in Primary Human Dermal Fibroblasts

Heo, Jin-Woong; Lee, Hye Eun; Lee, Jimin et al. · 2023 · DOI

Full title: Vutiglabridin Alleviates Cellular Senescence Process of Dysfunctional Replication, Metabolic Regulation, and Circadian Clock in Primary Human Dermal Fibroblasts

Authors: Heo, Jin-Woong; Lee, Hye Eun; Lee, Jimin; Choi, Leo Sungwong; Shin, Jaejin; Mun, Ji Young; Park, Hyung Soon; Park, Sang Chul; Nam, Chang‐Hoon

Year: 2023

DOI: https://doi.org/10.1101/2023.02.12.528227

Paper Colchicine inhibited oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: Implications in vascular diseases

Zhou, Huakang; Khan, Dilaware; Hussain, Sajid Muhammad et al. · 2023 · DOI

Full title: Colchicine inhibited oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: Implications in vascular diseases

Authors: Zhou, Huakang; Khan, Dilaware; Hussain, Sajid Muhammad; Gerdes, Norbert; Hagenbeck, Carsten; Rana, Majeed; Cornelius, Jan F.; Muhammad, Sajjad

Year: 2023

DOI: https://doi.org/10.1101/2023.08.04.552075

Paper Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

Julio Aguado; Alberto A. Amarilla; Atefeh Taherian Fard et al. · 2023 · bioRxiv · DOI

Full title: Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

Year: 2023

Venue: bioRxiv

Paper Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness

Eskiocak, Onur; Chowdhury, Saria; Shah, Vyom et al. · 2024 · DOI

Full title: Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness

Authors: Eskiocak, Onur; Chowdhury, Saria; Shah, Vyom; Nnuji-John, Emmanuella; Chung, Charlie; Boyer, Jacob A.; Harris, Alexander S.; Habel, Jill; Sadelain, Michel; Beyaz, Semir; Amor, Corina

Year: 2024

DOI: https://doi.org/10.1101/2024.03.19.585779

Paper Urinary Clusterin is a Biomarker of Renal Epithelial Senescence and Predicts Human Kidney Disease Progression

David P. Baird; Max Reck; Ross Campbell et al. · 2024 · medRxiv · DOI

Full title: Urinary Clusterin is a Biomarker of Renal Epithelial Senescence and Predicts Human Kidney Disease Progression

Authors: David P. Baird; Max Reck; Ross Campbell; M. Docherty; Piotr P. Janas; Tilly Mason; Zenuida Mortuza; Matthieu Vermeren; Andy Nam; Wei Yang; Nathan Schurman; Claire Williams; Jamie P. Traynor; Patrick B Mark; K. Mylonas; J. Hughes; Laura Denby; B. Conway; D. Ferenbach

Year: 2024

Venue: medRxiv

DOI: https://doi.org/10.1101/2024.03.14.24303997

Paper Senescence of endplate osteoclasts induces sensory innervation and spinal pain

Pan, Dayu; Benkato, Kheiria Gamal; Han, Xuequan et al. · 2023 · DOI

Full title: Senescence of endplate osteoclasts induces sensory innervation and spinal pain

Authors: Pan, Dayu; Benkato, Kheiria Gamal; Han, Xuequan; Zheng, Jinjian; Kumar, Vijay; Wan, Mei; Zheng, Junying; Cao, Xu

Year: 2023

Paper Senolytic Intervention Improves Cognition, Metabolism, and Adiposity in Female APP NL-F/NL-F Mice

Fang, Yimin; Peck, Mackenzie R.; Quinn, Kathleen et al. · 2023 · DOI

Full title: Senolytic Intervention Improves Cognition, Metabolism, and Adiposity in Female APP NL-F/NL-F Mice

Authors: Fang, Yimin; Peck, Mackenzie R.; Quinn, Kathleen; Chapman, Jenelle E.; Medina, David X.; McFadden, Samuel; Bartke, Andrzej; Hascup, Kevin N.; Hascup, Erin R.

Year: 2023

DOI: https://doi.org/10.1101/2023.12.12.571277

Paper CD4 T Cells Acquire Cytotoxic Properties to Modulate Cellular Senescence and Aging

Elyahu, Yehezqel; Feygin, Ilana; Pinkas, Noa et al. · 2024 · DOI

Full title: CD4 T Cells Acquire Cytotoxic Properties to Modulate Cellular Senescence and Aging

Authors: Elyahu, Yehezqel; Feygin, Ilana; Pinkas, Noa; Zemer, Alon; Shicht, Amit; Berner, Omer; Eremenko, Ekaterina; Nemirovsky, Anna; Reshef, Keren; Roitman, Lior; Krizhanovsky, Valery; Monsonego, Alon

Year: 2024

DOI: https://doi.org/10.1101/2024.01.14.575313

Paper Suppression of autophagy induces senescence in the heart.

Zhai, Peiyong; Sung, Eun-Ah; Shiheido-Watanabe, Yuka et al. · 2024 · Journal of molecular and cellular cardiology · DOI

Full title: Suppression of autophagy induces senescence in the heart.

Authors: Zhai, Peiyong; Sung, Eun-Ah; Shiheido-Watanabe, Yuka; Takayama, Koichiro; Tian, Yimin; Sadoshima, Junichi

Year: 2024

Venue: Journal of molecular and cellular cardiology

DOI: https://doi.org/10.1016/j.yjmcc.2024.08.001

Paper Primary oocytes with cellular senescence features are involved in ovarian aging in mice

Hao Yan; Edgar Andres Diaz Miranda; Shiying Jin et al. · 2024 · bioRxiv · DOI

Full title: Primary oocytes with cellular senescence features are involved in ovarian aging in mice

Authors: Hao Yan; Edgar Andres Diaz Miranda; Shiying Jin; Faith Wilson; Kang An; Brooke Godbee; Xiaobin Zheng; Astrid Roshealy Brau-Rodríguez; Lei Lei

Year: 2024

Venue: bioRxiv

Paper Aging and injury drive neuronal senescence in the dorsal root ganglia.

Donovan, Lauren J; Brewer, Chelsie L; Bond, Sabrina F et al. · 2024 · bioRxiv : the preprint server for biology · DOI

Full title: Aging and injury drive neuronal senescence in the dorsal root ganglia.

Authors: Donovan, Lauren J; Brewer, Chelsie L; Bond, Sabrina F; Lopez, Aleishai Pena; Hansen, Linus H; Jordan, Claire E; González, Oscar C; de Lecea, Luis; Kauer, Julie A; Tawfik, Vivianne L

Year: 2024

Venue: bioRxiv : the preprint server for biology

DOI: https://doi.org/10.1101/2024.01.20.576299

Paper Chemo-senolytic therapeutic potential against angiosarcoma

Xuebing Wang; C. Y. Chung; A. Yoshioka et al. · 2023 · bioRxiv · DOI

Full title: Chemo-senolytic therapeutic potential against angiosarcoma

Authors: Xuebing Wang; C. Y. Chung; A. Yoshioka; Shinya Hashimoto; H. Jimbo; Hideki Tanizawa; Shinya Ohta; T. Fukumoto; Ken-ichi Noma

Year: 2023

Venue: bioRxiv

DOI: https://doi.org/10.1101/2023.10.19.563192

Paper IAP antagonists potentiate TNFα-triggered apoptosis but selectively eliminate senescent tumor cells independently of TNFα

Hiroaki Ochiiwa; Takeshi Wakasa; Yuki Kataoka et al. · 2025 · bioRxiv · DOI

Full title: IAP antagonists potentiate TNFα-triggered apoptosis but selectively eliminate senescent tumor cells independently of TNFα

Authors: Hiroaki Ochiiwa; Takeshi Wakasa; Yuki Kataoka; K. Ando; E. Oki; Yoshihiko Maehara; M. Iimori; Hiroyuki Kitao

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.02.03.636172

Paper Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy model.

Yao, Minmin; Wei, Zhiliang; Nielsen, Jonathan Scharff et al. · 2024 · Neurobiology of disease · DOI

Full title: Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy model.

Authors: Yao, Minmin; Wei, Zhiliang; Nielsen, Jonathan Scharff; Ouyang, Yuxiao; Kakazu, Aaron; Wang, Haitong; Du, Lida; Li, Ruoxuan; Chu, Tiffany; Scafidi, Susanna; Lu, Hanzhang; Aggarwal, Manisha; Duan, Wenzhen

Year: 2024

Venue: Neurobiology of disease

DOI: https://doi.org/10.1016/j.nbd.2024.106711

Paper Senolytic Treatment for Low Back Pain

M. Mannarino; Hosni Cherif; Saber Ghazizadeh et al. · 2024 · bioRxiv · DOI

Full title: Senolytic Treatment for Low Back Pain

Authors: M. Mannarino; Hosni Cherif; Saber Ghazizadeh; Oliver Wu Martinez; Kai Sheng; Elsa Cousineau; Seunghwan Lee; M. Millecamps; Chan Gao; Jean A. Ouellet; Laura S Stone; L. Haglund

Year: 2024

Venue: bioRxiv

DOI: https://doi.org/10.1101/2024.01.15.575738

Paper Senolytic treatment with fisetin reverses age-related endothelial dysfunction partially mediated by SASP factor CXCL12.

Mahoney, Sophia A; Mazan-Mamczarz, Krystyna; Tsitsipatis, Dimitrios et al. · 2025 · bioRxiv : the preprint server for biology · DOI

Full title: Senolytic treatment with fisetin reverses age-related endothelial dysfunction partially mediated by SASP factor CXCL12.

Authors: Mahoney, Sophia A; Mazan-Mamczarz, Krystyna; Tsitsipatis, Dimitrios; VanDongen, Nicholas S; Henry-Smith, Charnae'; Okereke, Ada N; Munk, Rachel; Darvish, Sanna; Murray, Kevin O; De, Supriyo; Gorospe, Myriam; Seals, Douglas R; Rossman, Matthew J; Herman, Allison B; Clayton, Zachary S

Year: 2025

Venue: bioRxiv : the preprint server for biology

DOI: https://doi.org/10.1101/2025.08.13.670216

Paper Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by promoting the release of pro-anabolic mediators

Maurer, Svenja; Kirsch, Valeria; Ruths, Leonie et al. · 2024 · DOI

Full title: Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by promoting the release of pro-anabolic mediators

Authors: Maurer, Svenja; Kirsch, Valeria; Ruths, Leonie; Brenner, Rolf E.; Riegger, Jana

Year: 2024

DOI: https://doi.org/10.1101/2024.04.04.588076

Paper DNAm aging biomarkers are responsive: Insights from 51 longevity interventional studies in humans

Raghav Sehgal; D. Borrus; Jessica Kasamato et al. · 2024 · bioRxiv · DOI

Full title: DNAm aging biomarkers are responsive: Insights from 51 longevity interventional studies in humans

Authors: Raghav Sehgal; D. Borrus; Jessica Kasamato; Jenel F. Armstrong; John T. González; Yaroslav Markov; Ahana Priyanka; Ryan Smith; Natàlia Carreras; Varun B. Dwaraka; A. Higgins-Chen

Year: 2024

Venue: bioRxiv

DOI: https://doi.org/10.1101/2024.10.22.619522

Paper Targeted inhibition of Bcl-xL following radiation reduces tumourigenesis in preclinical models of H3K27M-altered diffuse midline glioma

Ashley Vardon; S. Haston; Romain Guiho et al. · 2024 · bioRxiv · DOI

Full title: Targeted inhibition of Bcl-xL following radiation reduces tumourigenesis in preclinical models of H3K27M-altered diffuse midline glioma

Authors: Ashley Vardon; S. Haston; Romain Guiho; Diana Carvahlo; Rebecca Carter; J. Boult; Daniel Gharai; Diwakar Santhakumar; Ielyaas Cloete; James Gray; John Apps; O. Ogunbiyi; Daohong Zhou; Guangrong Zheng; R. Martínez-Máñez; Mark Lythgoe; Laura Donovan; A. Carcaboso; Owen Williams; Jesús Gil; Thomas S. Jacques; J. Dean; D. Michod; Chris Jones; Darren Hargrave; J. Martínez-Barbera

Year: 2024

Venue: bioRxiv

DOI: https://doi.org/10.1101/2024.12.20.629607

Paper Eg5 Inhibitor SB743921 Causes p53-Dependent Cell Cycle Arrest, Senescence and Death in Tumor Cells

Iaroslav E. Abramenko; A. Khamidullina; T. A. Kiryukhina et al. · 2025 · bioRxiv · DOI

Full title: Eg5 Inhibitor SB743921 Causes p53-Dependent Cell Cycle Arrest, Senescence and Death in Tumor Cells

Authors: Iaroslav E. Abramenko; A. Khamidullina; T. A. Kiryukhina; A. Tvorogova; Nataliya G. Pavlenko; A. V. Bruter; V. Tatarskiy

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.01.23.634373

Paper Translating the Science of Aging into Therapeutic Interventions

Kirkland, James L. · 2016 · Cold Spring Harbor Perspectives in Medicine · DOI

Full title: Translating the Science of Aging into Therapeutic Interventions

Authors: Kirkland, James L.

Year: 2016

Venue: Cold Spring Harbor Perspectives in Medicine

DOI: https://doi.org/10.1101/cshperspect.a025908

Paper Elimination of senescent cells with senolytic host-directed therapy reduces tuberculosis progression in mice

Somnath Shee; Yazmin B. Martinez-Martinez; Benjamin Koleske et al. · 2025 · bioRxiv · DOI

Full title: Elimination of senescent cells with senolytic host-directed therapy reduces tuberculosis progression in mice

Authors: Somnath Shee; Yazmin B. Martinez-Martinez; Benjamin Koleske; Shivraj M. Yabaji; L. Kobzik; Igor Kramnik; William R. Bishai

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.03.28.645957

Paper Targeting breast cancer senescence in 3D models of bone metastasis

Eleane C B Hamburger; Mansoureh Mohseni Garakani; Saleh Alfaisali et al. · 2025 · bioRxiv · DOI

Full title: Targeting breast cancer senescence in 3D models of bone metastasis

Authors: Eleane C B Hamburger; Mansoureh Mohseni Garakani; Saleh Alfaisali; Jean A. Ouellet; Michael H. Weber; Livia Garzia; Lisbet Haglund; D. Rosenzweig

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.06.26.661856

Paper Aged‐senescent cells contribute to impaired heart regeneration

Fiona C Lewis-McDougall; P. Ruchaya; Eva Domenjo-Vila et al. · 2018 · bioRxiv · DOI

Full title: Aged‐senescent cells contribute to impaired heart regeneration

Authors: Fiona C Lewis-McDougall; P. Ruchaya; Eva Domenjo-Vila; Tze Shin Teoh; L. Prata; Beverley J. Cottle; J. Clark; P. Punjabi; Wael I Awad; D. Torella; T. Tchkonia; J. Kirkland; G. Ellison‐Hughes

Year: 2018

Venue: bioRxiv

DOI: https://doi.org/10.1111/acel.12931

Paper Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers

Utkarsh Tripathi; Masayoshi Suda; Vagisha Kulshreshtha et al. · 2025 · bioRxiv · DOI

Full title: Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers

Authors: Utkarsh Tripathi; Masayoshi Suda; Vagisha Kulshreshtha; Bryan T Piatkowski; Allyson K Palmer; N. Giorgadze; C. Inman; Nathan S. Gasek; Ming Xu; Kurt O. Johnson; T. Pirtskhalava; Selim Chaib; L. Prata; Yi Zhu; Renuka Kandhaya-Pillai; Stefan G. Tullius; Saranya P. Wyles; Rambabu Majji; H. Yalamanchili; David B. Allison; T. Tchkonia; James L. Kirkland

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.08.27.672709

Paper A DNA Methylation Fingerprint of Cellular Senescence

Levine, Morgan E.; Leung, Diana L.; Minteer, Christopher J. et al. · 2019 · DOI

Full title: A DNA Methylation Fingerprint of Cellular Senescence

Authors: Levine, Morgan E.; Leung, Diana L.; Minteer, Christopher J.; Gonzalez, John

Year: 2019

DOI: https://doi.org/10.1101/674580

Paper Tau protein aggregation induces cellular senescence in the brain

N. Musi; Joseph M. Valentine; K. R. Sickora et al. · 2018 · bioRxiv · DOI

Full title: Tau protein aggregation induces cellular senescence in the brain

Authors: N. Musi; Joseph M. Valentine; K. R. Sickora; Eric Baeuerle; C. S. Thompson; Ashley Zapata; Q. Shen; Miranda E. Orr

Year: 2018

Venue: bioRxiv

DOI: https://doi.org/10.1101/369074

Paper Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice

Davidová, Eliška; Trnovská, Jaroslava; Svoboda, Petr et al. · 2022 · Nature Communications · DOI

Full title: Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice

Authors: Davidová, Eliška; Trnovská, Jaroslava; Svoboda, Petr; Škop, Vojtěch; Novosadová, Vendula; Reguera, David Pajuelo; Petrezsélyová, Silvia; Piavaux, Benoit; Endaya, Berwini; Špoutil, František; Zudová, Dagmar; Štursa, Jan; Melčová, Magdalena; Bielčiková, Zuzana; Werner, Lukáš; Procházka, Jan; Sedláček, Radislav; Hüttl, Martina; Hubáčková, Soňa; Haluzı́k, Martin; Neužil, Jiřı́

Year: 2022

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-022-29486-z

Paper Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence.

Fleury, Hubert; Malaquin, Nicolas; Tu, Véronique et al. · 2019 · Nature communications · DOI

Full title: Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence.

Authors: Fleury, Hubert; Malaquin, Nicolas; Tu, Véronique; Gilbert, Sophie; Martinez, Aurélie; Olivier, Marc-Alexandre; Sauriol, Skye Alexandre; Communal, Laudine; Leclerc-Desaulniers, Kim; Carmona, Euridice; Provencher, Diane; Mes-Masson, Anne-Marie; Rodier, Francis

Year: 2019

Venue: Nature communications

DOI: https://doi.org/10.1038/s41467-019-10460-1

Paper Immune checkpoint inhibitors as senolytic agents

Parminderjit Singh; P. Kapahi; J. V. van Deursen · 2022 · Cell Research · DOI

Full title: Immune checkpoint inhibitors as senolytic agents

Authors: Parminderjit Singh; P. Kapahi; J. V. van Deursen

Year: 2022

Venue: Cell Research

DOI: https://doi.org/10.1038/s41422-022-00761-4

Paper Identification of HSP90 inhibitors as a novel class of senolytics

Fuhrmann‐Stroissnigg, Heike; Ling, Yuan Yuan; Zhao, Jing et al. · 2017 · Nature Communications · DOI

Full title: Identification of HSP90 inhibitors as a novel class of senolytics

Authors: Fuhrmann‐Stroissnigg, Heike; Ling, Yuan Yuan; Zhao, Jing; McGowan, Sara J.; Zhu, Yi; Brooks, Robert W.; Grassi, Diego; Gregg, Siobhán Q.; Stripay, Jennifer L.; Dorronsoro, Akaitz; Corbo, Lana; Tang, Priscilla; Bukata, Christina; Ring, Nadja; Giacca, Mauro; Li, Xuesen; Tchkonia, Tamar; Kirkland, James L.; Niedernhofer, Laura J.; Robbins, Paul D.

Year: 2017

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-017-00314-z

Paper A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

D. Saul; R. L. Kosinsky; E. Atkinson et al. · 2021 · Nature Communications · DOI

Full title: A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

Authors: D. Saul; R. L. Kosinsky; E. Atkinson; Madison L. Doolittle; Xu Zhang; N. LeBrasseur; R. Pignolo; P. Robbins; L. Niedernhofer; Y. Ikeno; D. Jurk; J. Passos; L. Hickson; A. Xue; D. Monroe; T. Tchkonia; J. Kirkland; J. Farr; S. Khosla

Year: 2021

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-022-32552-1

Paper Impaired immune surveillance accelerates accumulation of senescent cells and aging

Ovadya, Yossi; Landsberger, Tomer; Leins, Hanna et al. · 2018 · Nature Communications · DOI

Full title: Impaired immune surveillance accelerates accumulation of senescent cells and aging

Authors: Ovadya, Yossi; Landsberger, Tomer; Leins, Hanna; Vadai, Ezra; Gal, Hilah; Biran, Anat; Yosef, Reut; Sagiv, Adi; Agrawal, Amit; Shapira, Alon; Windheim, Joseph; Tsoory, Michael; Schirmbeck, Reinhold; Amit, Ido; Geiger, Hartmut; Krizhanovsky, Valery

Year: 2018

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-018-07825-3

Paper A β-galactosidase kiss of death for senescent cells

Xiaoqian Liu; J. Belmonte; Weiqi Zhang et al. · 2020 · Cell Research · DOI

Full title: A β-galactosidase kiss of death for senescent cells

Authors: Xiaoqian Liu; J. Belmonte; Weiqi Zhang; Guang-Hui Liu

Year: 2020

Venue: Cell Research

DOI: https://doi.org/10.1038/s41422-020-0325-6

Paper Senescent cells limit p53 activity via multiple mechanisms to remain viable.

Sturmlechner, Ines; Sine, Chance C; Jeganathan, Karthik B et al. · 2022 · Nature communications · DOI

Full title: Senescent cells limit p53 activity via multiple mechanisms to remain viable.

Authors: Sturmlechner, Ines; Sine, Chance C; Jeganathan, Karthik B; Zhang, Cheng; Fierro Velasco, Raul O; Baker, Darren J; Li, Hu; van Deursen, Jan M

Year: 2022

Venue: Nature communications

DOI: https://doi.org/10.1038/s41467-022-31239-x

Paper A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

Wakita, Masahiro; Takahashi, Akiko; Sano, Osamu et al. · 2020 · Nature Communications · DOI

Full title: A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

Authors: Wakita, Masahiro; Takahashi, Akiko; Sano, Osamu; Loo, Tze Mun; Imai, Yoshinori; Narukawa, Megumi; Iwata, Hidehisa; Matsudaira, Tatsuyuki; Kawamoto, Shimpei; Ohtani, Naoko; Yoshimori, Tamotsu; Hara, Eiji

Year: 2020

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-020-15719-6

Paper Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice

Khan, Sajid; Kellish, Patrick; Connis, Nick et al. · 2023 · Cell Death Discovery · DOI

Full title: Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice

Authors: Khan, Sajid; Kellish, Patrick; Connis, Nick; Thummuri, Dinesh; Wiegand, J; Zhang, Peiyi; Zhang, Xuan; Budamagunta, Vivekananda; Hua, Nan; Yang, Yang; De, Umasankar; Jin, Lingtao; Zhang, Weizhou; Zheng, Guangrong; Hromas, Robert; Hann, Christine L.; Zajac‐Kaye, Maria; Kaye, Frederic J.; Zhou, Daohong

Year: 2023

Venue: Cell Death Discovery

DOI: https://doi.org/10.1038/s41420-022-01296-8

Paper Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations

Wang, Yuan; Deng, Peng; Liu, Yuting et al. · 2020 · Nature Communications · DOI

Full title: Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations

Authors: Wang, Yuan; Deng, Peng; Liu, Yuting; Wu, Yunshu; Chen, Yaqian; Guo, Yuchen; Zhang, Shiwen; Zheng, Xiaofei; Zhou, Liyan; Liu, Weiqing; Li, Qiwen; Lin, Weimin; Qi, Xingying; Ou, Guomin; Wang, Cun‐Yu; Yuan, Quan

Year: 2020

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-020-19360-1

Paper Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton

Madison L. Doolittle; D. Saul; J. Kaur et al. · 2023 · Nature Communications · DOI

Full title: Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton

Authors: Madison L. Doolittle; D. Saul; J. Kaur; Jennifer L. Rowsey; Stephanie J. Vos; K. Pavelko; J. Farr; D. Monroe; S. Khosla

Year: 2023

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-023-40393-9

Paper Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer.

Troiani, Martina; Colucci, Manuel; D'Ambrosio, Mariantonietta et al. · 2022 · Nature communications · DOI

Full title: Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer.

Authors: Troiani, Martina; Colucci, Manuel; D'Ambrosio, Mariantonietta; Guccini, Ilaria; Pasquini, Emiliano; Varesi, Angelica; Valdata, Aurora; Mosole, Simone; Revandkar, Ajinkya; Attanasio, Giuseppe; Rinaldi, Andrea; Rinaldi, Anna; Bolis, Marco; Cippà, Pietro; Alimonti, Andrea

Year: 2022

Venue: Nature communications

DOI: https://doi.org/10.1038/s41467-022-29824-1

Paper Challenges in developing Geroscience trials

Rolland, Yves; Sierra, Felipe; Ferrucci, Luigi et al. · 2023 · Nature Communications · DOI

Full title: Challenges in developing Geroscience trials

Authors: Rolland, Yves; Sierra, Felipe; Ferrucci, Luigi; Barzilai, Nir; Cabo, Rafael de; Mannick, Joan B.; Oliva, Anthony A.; Evans, William J.; Angioni, Davide; Barreto, Philipe de Souto; Raffin, Jérémy; Vellas, Bruno; Kirkland, James L.; Andrieu, Sandrine; Bacqueville, Daniel; Bischoff‐Ferrari, Heike A.; Blivet, Guillaume; Cash, Timothy P.; Cuervo, Ana-Maria; Davezac, Noélie; Dimet‐Wiley, Andrea; Fleming, Alexander; Gérard, Friedlander; Gonzales, Mitzi M.; Guyonnet, Sophie; Hare, Joshua M.; Hendrix, Suzanne; Jørgensen, Christian; Kaeberlein, Matt; Khan, Mehmood; Kritchevsky, Stephen B.; Labokha, Aksana; Lairez, Olivier; Lederman, Stephanie; Mariani, Jean; Middleton, Lefkos; Newman, John C.; Parini, Angelo; Peschin, Susan; Prunotto, Marco; Sagol, Sami; Tomlinson, Suzanne M.; Terstappen, Georg C.; Touchon, Jacques; Tourette, Cendrine; Maanen, Rob van; Verdin, Eric; Watowich, Stan; Zhang, Lei; Zhavoronkov, Alex; Zhavoronkov, Alex

Year: 2023

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-023-39786-7

Paper A BDNF-TrkB autocrine loop enhances senescent cell viability

Anerillas, Carlos; Herman, Allison B.; Munk, Rachel et al. · 2022 · Nature Communications · DOI

Full title: A BDNF-TrkB autocrine loop enhances senescent cell viability

Year: 2022

Venue: Nature Communications

Paper Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma

Salam, Rana; Saliou, Alexa; Bielle, Franck et al. · 2023 · Nature Communications · DOI

Full title: Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma

Year: 2023

Venue: Nature Communications

Paper Clearance of defective muscle stem cells by senolytics restores myogenesis in myotonic dystrophy type 1.

Conte, Talita C; Duran-Bishop, Gilberto; Orfi, Zakaria et al. · 2023 · Nature communications · DOI

Full title: Clearance of defective muscle stem cells by senolytics restores myogenesis in myotonic dystrophy type 1.

Authors: Conte, Talita C; Duran-Bishop, Gilberto; Orfi, Zakaria; Mokhtari, Inès; Deprez, Alyson; Côté, Isabelle; Molina, Thomas; Kim, Tae-Yeon; Tellier, Lydia; Roussel, Marie-Pier; Maggiorani, Damien; Benabdallah, Basma; Leclerc, Severine; Feulner, Lara; Pellerito, Ornella; Mathieu, Jean; Andelfinger, Gregor; Gagnon, Cynthia; Beauséjour, Christian; McGraw, Serge; Duchesne, Elise; Dumont, Nicolas A

Year: 2023

Venue: Nature communications

DOI: https://doi.org/10.1038/s41467-023-39663-3

Paper Senescent-like microglia limit remyelination through the senescence associated secretory phenotype

Phillip S. Gross; Violeta Durán-Laforet; Lana T. Ho et al. · 2025 · Nature Communications · DOI

Full title: Senescent-like microglia limit remyelination through the senescence associated secretory phenotype

Authors: Phillip S. Gross; Violeta Durán-Laforet; Lana T. Ho; George S. Melchor; Sameera Zia; Zeeba Manavi; William E. Barclay; Sung Hyun Lee; Nataliia Shults; Sean Selva; Enrique Alvarez; J. Plemel; Meng-meng Fu; Dorothy P. Schafer; Jeffrey K. Huang

Year: 2025

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-025-57632-w

Paper Discovery of senolytics using machine learning

Smer-Barreto, Vanessa; Quintanilla, Andrea; Elliott, Richard et al. · 2023 · Nature Communications · DOI

Full title: Discovery of senolytics using machine learning

Authors: Smer-Barreto, Vanessa; Quintanilla, Andrea; Elliott, Richard; Dawson, John C.; Sun, Jiugeng; Campa, Víctor M.; Lorente‐Macías, Álvaro; Unciti‐Broceta, Asier; Carragher, Neil O.; Acosta, Juan Carlos; Oyarzún, Diego A.

Year: 2023

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-023-39120-1

Paper Detection of senescence using machine learning algorithms based on nuclear features

Imanol Durán; Joaquim Pombo; Bin Sun et al. · 2024 · Nature Communications · DOI

Full title: Detection of senescence using machine learning algorithms based on nuclear features

Authors: Imanol Durán; Joaquim Pombo; Bin Sun; S. Gallage; Hiromi Kudo; Domhnall McHugh; Laura Bousset; J. E. Barragan Avila; R. Forlano; P. Manousou; Mathias Heikenwalder; Dominic J. Withers; Santiago Vernia; R. Goldin; Jesús Gil

Year: 2024

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-024-45421-w

Paper Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice

Fan, Yonggang; Zhang, Weixin; Huang, Xiusheng et al. · 2024 · Nature Communications · DOI

Full title: Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice

Authors: Fan, Yonggang; Zhang, Weixin; Huang, Xiusheng; Fan, Mingzhe; Shi, Chenhao; Zhao, Lantian; Pi, Guofu; Zhang, Huafeng; Ni, Shuangfei

Year: 2024

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-024-47317-1

Paper Blocking negative effects of senescence in human skin fibroblasts with a plant extract

I. Lämmermann; Lucia Terlecki-Zaniewicz; R. Weinmüllner et al. · 2018 · npj Aging and Mechanisms of Disease · DOI

Full title: Blocking negative effects of senescence in human skin fibroblasts with a plant extract

Authors: I. Lämmermann; Lucia Terlecki-Zaniewicz; R. Weinmüllner; M. Schosserer; H. Dellago; André Dargen de Matos Branco; Dominik Autheried; Benjamin Sevcnikar; Lisa Kleissl; Irina Berlin; F. Morizot; F. Lejeune; N. Fuzzati; Sandra Forestier; A. Toribio; Anaïs Tromeur; Lionel Weinberg; Juan Carlos Higareda Almaraz; M. Scheideler; M. Rietveld; A. El Ghalbzouri; E. Tschachler; F. Gruber; J. Grillari

Year: 2018

Venue: npj Aging and Mechanisms of Disease

DOI: https://doi.org/10.1038/s41514-018-0023-5

Paper Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia.

Li, Yang; Li, Chuhan; Zhou, Qin et al. · 2025 · Nature communications · DOI

Full title: Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia.

Authors: Li, Yang; Li, Chuhan; Zhou, Qin; Liu, Xingyuan; Qiao, Yulong; Xie, Ting; Sun, Hao; Ong, Michael Tim-Yun; Wang, Huating

Year: 2025

Venue: Nature communications

DOI: https://doi.org/10.1038/s41467-025-61403-y

Paper Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease

Chiara, Letizia De; Conte, Carolina; Semeraro, Roberto et al. · 2022 · Nature Communications · DOI

Full title: Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease

Authors: Chiara, Letizia De; Conte, Carolina; Semeraro, Roberto; Díaz-Bulnes, Paula; Angelotti, Maria Lucia; Mazzinghi, Benedetta; Molli, Alice; Antonelli, Giulia; Landini, Samuela; Melica, Maria Elena; Peired, Anna Julie; Maggi, Laura; Donati, Marta; Regina, Gilda La; Allinovi, Marco; Ravaglia, Fiammetta; Guasti, Daniele; Bani, Danièle; Cirillo, Luigi; Becherucci, Francesca; Guzzi, Francesco; Magi, Alberto; Annunziato, Francesco; Lasagni, Laura; Anders, Hans‐Joachim; Lazzeri, Elena; Romagnani, Paola

Year: 2022

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-022-33110-5

Paper Local H2 release remodels senescence microenvironment for improved repair of injured bone

Chen, Shengqiang; Yu, Yuanman; Xie, Songqing et al. · 2023 · Nature Communications · DOI

Full title: Local H2 release remodels senescence microenvironment for improved repair of injured bone

Authors: Chen, Shengqiang; Yu, Yuanman; Xie, Songqing; Liang, Danna; Shi, Wei; Chen, Sizhen; Li, Guanglin; Tang, Wei; Liu, Changsheng; He, Qianjun

Year: 2023

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-023-43618-z

Paper A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging

Linders, Annet N.; Dias, Itamar Braga; López‐Fernández, Teresa et al. · 2024 · npj Aging · DOI

Full title: A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging

Authors: Linders, Annet N.; Dias, Itamar Braga; López‐Fernández, Teresa; Tocchetti, Carlo G.; Bömer, Nils; Meer, Peter van der

Year: 2024

Venue: npj Aging

DOI: https://doi.org/10.1038/s41514-024-00135-7

Paper Increased vascular smooth muscle cell senescence in aneurysmal Fibulin-4 mutant mice.

Stefens, Sanne J M; van Vliet, Nicole; IJpma, Arne et al. · 2024 · npj aging · DOI

Full title: Increased vascular smooth muscle cell senescence in aneurysmal Fibulin-4 mutant mice.

Authors: Stefens, Sanne J M; van Vliet, Nicole; IJpma, Arne; Burger, Joyce; Li, Yunlei; van Heijningen, Paula M; Lindeman, Jan H N; Majoor-Krakauer, Danielle; Verhagen, Hence J M; Kanaar, Roland; Essers, Jeroen; van der Pluijm, Ingrid

Year: 2024

Venue: npj aging

DOI: https://doi.org/10.1038/s41514-024-00154-4

Paper The role of cellular senescence in ovarian aging.

Hense, Jéssica D; Isola, José V V; Garcia, Driele N et al. · 2024 · npj aging · DOI

Full title: The role of cellular senescence in ovarian aging.

Authors: Hense, Jéssica D; Isola, José V V; Garcia, Driele N; Magalhães, Larissa S; Masternak, Michal M; Stout, Michael B; Schneider, Augusto

Year: 2024

Venue: npj aging

DOI: https://doi.org/10.1038/s41514-024-00157-1

Paper Chemotherapy-induced adipo-lineage cell senescence drives bone loss.

Raut, Ganesh Kumar; Malachowski, Taylor; Melam, Anupama et al. · 2025 · Nature communications · DOI

Full title: Chemotherapy-induced adipo-lineage cell senescence drives bone loss.

Authors: Raut, Ganesh Kumar; Malachowski, Taylor; Melam, Anupama; Ramalho-Oliveira, Renata; Holt, Taylor; Luo, Xianmin; Yao, Zhangting; Faget, Douglas V; Ren, Qihao; DeNardo, David G; Stewart, Sheila A

Year: 2025

Venue: Nature communications

DOI: https://doi.org/10.1038/s41467-025-67793-3

Paper SGLT2 inhibitors as a novel senotherapeutic approach

Z. E. Yesilyurt-Dirican; Ce Qi; Yi-Chian Wang et al. · 2025 · npj Aging · DOI

Full title: SGLT2 inhibitors as a novel senotherapeutic approach

Authors: Z. E. Yesilyurt-Dirican; Ce Qi; Yi-Chian Wang; Annika Simm; Laura Deelen; Alia Hafiz Abbas Gasim; Fiona C Lewis-McDougall; G. Ellison‐Hughes

Year: 2025

Venue: npj Aging

DOI: https://doi.org/10.1038/s41514-025-00227-y

Paper Senescence drives immunotherapy resistance by inducing an immunosuppressive tumor microenvironment

Maggiorani, Damien; Lê, Oanh; Lisi, Véronique et al. · 2024 · Nature Communications · DOI

Full title: Senescence drives immunotherapy resistance by inducing an immunosuppressive tumor microenvironment

Authors: Maggiorani, Damien; Lê, Oanh; Lisi, Véronique; Landais, Séverine; Moquin‐Beaudry, Gaël; Lavallée, Vincent‐Philippe; Decaluwe, Hélène; Beauséjour, Christian

Year: 2024

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-024-46769-9

Paper Longevity leap: mind the healthspan gap

Garmany, Armin; Yamada, Satsuki; Terzic, André · 2021 · npj Regenerative Medicine · DOI

Full title: Longevity leap: mind the healthspan gap

Authors: Garmany, Armin; Yamada, Satsuki; Terzic, André

Year: 2021

Venue: npj Regenerative Medicine

DOI: https://doi.org/10.1038/s41536-021-00169-5

Paper Intermittent hypobaric pressure induces selective senescent cell death and alleviates age-related osteoporosis.

B. Meng; Yan Qu; Benyi Yang et al. · 2026 · Nature Biomedical Engineering · DOI

Full title: Intermittent hypobaric pressure induces selective senescent cell death and alleviates age-related osteoporosis.

Authors: B. Meng; Yan Qu; Benyi Yang; Chaoran Fu; Yifan He; Jing Li; Rentao Wan; Xin Li; Zhulin Xue; Zeyuan Cao; Meng Hao; Xiao Zhang; Zhe An; Fen Chen; Ruibao Ren; Xueli Mao; Yang Cao; Songtao Shi

Year: 2026

Venue: Nature Biomedical Engineering

DOI: https://doi.org/10.1038/s41551-025-01584-5

Paper Advancing multiple sclerosis management in older adults

Walt, Anneke van der; Strijbis, Eva; Bridge, Francesca et al. · 2025 · Nature Reviews Neurology · DOI

Full title: Advancing multiple sclerosis management in older adults

Authors: Walt, Anneke van der; Strijbis, Eva; Bridge, Francesca; Coetzee, Timothy; Graves, Jennifer; Brownlee, Wallace; Butzkueven, Helmut; Marrie, Ruth Ann; Hua, Le H.; Lampe, Anna T.; Tintoré, Mar; Montalbán, Xavier; Calabresi, Peter A.; Barkhof, Frederik; Abdelhak, Ahmed; Amato, Maria Pia; Amezcua, Lilyana; Azevedo, Christina; Banwell, Brenda; Bar‐Or, Amit; Bebo, Bruce F.; Chataway, Jeremy; Corboy, John R.; Correale, Jorge; Dawson, Valina Lynn; Finlayson, Marcia; Fujihara, Kazuo; Hawton, Annie; Hellwig, Kerstin; Kappos, Ludwig; Kos, Daphne; Krysko, Kristen M.; Kühle, Jens; Lebrun‐Frénay, Christine; Lublin, Fred; Magyari, Melinda; Miller, Aaron E.; Moccia, Marcello; Morrow, Sarah A.; Mowry, Ellen M; Oh, Jiwon; Pontillo, Giuseppe; Ramanathan, Sudarshini; Rocca, Maria A.; Salter, Amber; Salvetti, Marco; Sastre‐Garriga, Jaume; Smith, Kathryn E.; Sormani, Maria Pia; Stankoff, Bruno; Tremlett, Helen; Weinstock-Guttman, Bianca; Wiendl, Heinz; Zaratin, Paola; Zhang, Yi-Nan

Year: 2025

Venue: Nature Reviews Neurology

DOI: https://doi.org/10.1038/s41582-025-01115-5

Paper COVID-19 and cellular senescence

Schmitt, Clemens A.; Tchkonia, Tamar; Niedernhofer, Laura J. et al. · 2022 · Nature reviews. Immunology · DOI

Full title: COVID-19 and cellular senescence

Authors: Schmitt, Clemens A.; Tchkonia, Tamar; Niedernhofer, Laura J.; Robbins, Paul D.; Kirkland, James L.; Lee, Soyoung

Year: 2022

Venue: Nature reviews. Immunology

DOI: https://doi.org/10.1038/s41577-022-00785-2

Paper Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker.

Poblocka, Marta; Bassey, Akang Leonard; Smith, Victoria M et al. · 2021 · Scientific reports · DOI

Full title: Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker.

Authors: Poblocka, Marta; Bassey, Akang Leonard; Smith, Victoria M; Falcicchio, Marta; Manso, Ana Sousa; Althubiti, Mohammad; Sheng, XiaoBo; Kyle, Andrew; Barber, Ruth; Frigerio, Mark; Macip, Salvador

Year: 2021

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-021-99852-2

Paper Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF

Monkley, Susan J.; Overed-Sayer, Catherine; Parfrey, Helen et al. · 2021 · Scientific Reports · DOI

Full title: Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF

Authors: Monkley, Susan J.; Overed-Sayer, Catherine; Parfrey, Helen; Rassl, Doris M.; Crowther, Damian C.; Escudero‐Ibarz, Leire; Davis, Nicola; Carruthers, Alan; Berks, Richard; Coetzee, Marisa; Kołosionek, Ewa; Karlsson, Maria; Griffin, Leia R.; Clausen, Maryam; Belfield, Graham; Hogaboam, Cory M.; Murray, Lynne A.

Year: 2021

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-021-00769-7

Paper Cellular senescence-mediated exacerbation of Duchenne muscular dystrophy

Sugihara, Hidetoshi; Teramoto, Naomi; Nakamura, Katsuyuki et al. · 2020 · Scientific Reports · DOI

Full title: Cellular senescence-mediated exacerbation of Duchenne muscular dystrophy

Authors: Sugihara, Hidetoshi; Teramoto, Naomi; Nakamura, Katsuyuki; Shiga, Takanori; Shirakawa, Taku; Matsuo, Masafumi; Ogasawara, Masashi; Nishino, Ichizo; Matsuwaki, Takashi; Nishihara, Masugi; Yamanouchi, Keitaro

Year: 2020

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-020-73315-6

Paper GRP78/BiP determines senescence evasion cell fate after cisplatin-based chemotherapy

Zins Ei; Kanuengnit Choochuay; Alisa Tubsuwan et al. · 2021 · Scientific Reports · DOI

Full title: GRP78/BiP determines senescence evasion cell fate after cisplatin-based chemotherapy

Authors: Zins Ei; Kanuengnit Choochuay; Alisa Tubsuwan; Decha Pinkaew; M. Suksomtip; C. Vinayanuwattikun; P. Chanvorachote; Preedakorn Chunhacha

Year: 2021

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-021-01540-8

Paper Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom Syndromes

Kim Jee Goh; Jian-hua Chen; N. Rocha et al. · 2020 · Scientific Reports · DOI

Full title: Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom Syndromes

Authors: Kim Jee Goh; Jian-hua Chen; N. Rocha; R. Semple

Year: 2020

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-020-64136-8

Paper Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice

Acklin, Scarlett; Zhang, Manchao; Du, Wuying et al. · 2020 · Scientific Reports · DOI

Full title: Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice

Authors: Acklin, Scarlett; Zhang, Manchao; Du, Wuying; Zhao, Xin; Plotkin, Matthew; Chang, Jianhui; Campisi, Judith; Zhou, Daohong; Xia, Fen

Year: 2020

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-020-71042-6

Paper Higher senescence associated secretory phenotype and lower defense mediator in urinary extracellular vesicles of elders with and without Parkinson disease

S. Yeh; Chia-Hsueh Lin; Yun-Jung Yang et al. · 2021 · Scientific Reports · DOI

Full title: Higher senescence associated secretory phenotype and lower defense mediator in urinary extracellular vesicles of elders with and without Parkinson disease

Authors: S. Yeh; Chia-Hsueh Lin; Yun-Jung Yang; Li-Wei Lin; Chih-Wen Tseng; Kuender D Yang

Year: 2021

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-021-95062-y

Paper Advanced glycation end product (AGE) targeting antibody SIWA318H is efficacious in preclinical models for pancreatic cancer

Rossi, Gabriela R.; Jensen, Ashley W.; Ng, Serina et al. · 2023 · Scientific Reports · DOI

Full title: Advanced glycation end product (AGE) targeting antibody SIWA318H is efficacious in preclinical models for pancreatic cancer

Authors: Rossi, Gabriela R.; Jensen, Ashley W.; Ng, Serina; Yin, Zhirong; Li, Aimin; Misra, Anjan; Hoff, Daniel D. Von; Gruber, Lewis; Gruber, Misty; Han, Haiyong

Year: 2023

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-023-44211-6

Paper A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD+ precursor combination.

Simon, Katherine E; Russell, Katharine; Mondino, Alejandra et al. · 2024 · Scientific reports · DOI

Full title: A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD+ precursor combination.

Authors: Simon, Katherine E; Russell, Katharine; Mondino, Alejandra; Yang, Chin-Chieh; Case, Beth C; Anderson, Zachary; Whitley, Christine; Griffith, Emily; Gruen, Margaret E; Olby, Natasha J

Year: 2024

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-024-63031-w

Paper Senolytic cocktail dasatinib and quercetin attenuates chronic high altitude hypoxia associated bone loss in mice

Shen Wang; Juan Zhai; Ke Heng et al. · 2024 · Scientific Reports · DOI

Full title: Senolytic cocktail dasatinib and quercetin attenuates chronic high altitude hypoxia associated bone loss in mice

Authors: Shen Wang; Juan Zhai; Ke Heng; Liangwei Sha; Xingchen Song; Huaiyuan Zhai; Chengbai Dai; Jian Li; Fei Teng; Junli Huang; Guoqiang Wang; Yinuo Geng; Rui Geng; Qingguo Lu; Xinfa Nie; Kui Xue; Qilong Wang; Wanying Huang; Huanyu Zhang; Yuanji Yang; Junyun Lan; Dehong Yu; Yanhong Liu; Yilong Guo; Qinghe Geng

Year: 2024

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-024-82262-5

Paper Cellular senescence is associated with osteonecrosis of the femoral head while mesenchymal stem cell conditioned medium inhibits bone collapse

Okamoto, Masanori; Nakashima, Hiroaki; Sakai, Kiyoshi et al. · 2024 · Scientific Reports · DOI

Full title: Cellular senescence is associated with osteonecrosis of the femoral head while mesenchymal stem cell conditioned medium inhibits bone collapse

Authors: Okamoto, Masanori; Nakashima, Hiroaki; Sakai, Kiyoshi; Takegami, Yasuhiko; Osawa, Yusuke; Watanabe, Junna; Ito, Sadayuki; Hibi, Hideharu; Imagama, Shiro

Year: 2024

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-024-53400-w

Paper Primary oocytes with cellular senescence features are involved in ovarian aging in mice

Hao Yan; Edgar Andres Diaz Miranda; Shiying Jin et al. · 2024 · bioRxiv · DOI

Full title: Primary oocytes with cellular senescence features are involved in ovarian aging in mice

Authors: Hao Yan; Edgar Andres Diaz Miranda; Shiying Jin; Faith Wilson; Kang An; Brooke Godbee; Xiaobin Zheng; Astrid Roshealy Brau-Rodríguez; Lei Lei

Year: 2024

Venue: bioRxiv

Paper FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation

Yu-Xiang Kong; Zhi-Shuai Li; Yuanbo Liu et al. · 2025 · Communications Biology · DOI

Full title: FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation

Authors: Yu-Xiang Kong; Zhi-Shuai Li; Yuanbo Liu; Bo Pan; Xin Fu; Ran Xiao; Li Yan

Year: 2025

Venue: Communications Biology

DOI: https://doi.org/10.1038/s42003-025-07738-0

Paper Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

Meiners, Franziska; Hinz, Burkhard; Boeckmann, Lars et al. · 2024 · Scientific Reports · DOI

Full title: Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

Authors: Meiners, Franziska; Hinz, Burkhard; Boeckmann, Lars; Secci, Riccardo; Sueto, Salem Oduro Beffi; Kuepfer, Lars; Fuellen, Georg; Barrantes, Israel

Year: 2024

Venue: Scientific Reports

Paper An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence

C. Riviere-Cazaux; Lucas P Carlstrom; B. Neth et al. · 2023 · npj Precision Oncology · DOI

Full title: An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence

Authors: C. Riviere-Cazaux; Lucas P Carlstrom; B. Neth; Ian E Olson; K. Rajani; Masum Rahman; S. Ikram; Moustafa A. Mansour; Bipasha Mukherjee; A. Warrington; Susan C. Short; T. von Zglinicki; Desmond A. Brown; S. Burma; T. Tchkonia; Marissa J. Schafer; Darren J. Baker; S. Kizilbash; James L. Kirkland; Terry C Burns

Year: 2023

Venue: npj Precision Oncology

DOI: https://doi.org/10.1038/s41698-023-00476-8

Paper An effective system for senescence modulating drug development using quantitative high-content analysis and high-throughput screening

Hu, Yongfeng; Xue, Xueqi; Tian, Han et al. · 2025 · Communications Biology · DOI

Full title: An effective system for senescence modulating drug development using quantitative high-content analysis and high-throughput screening

Authors: Hu, Yongfeng; Xue, Xueqi; Tian, Han; Li, Ye; Zhang, Tonghui; Lu, Tao; Zhang, Peichuan

Year: 2025

Venue: Communications Biology

DOI: https://doi.org/10.1038/s42003-025-08758-6

Paper SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

Shunya Tsuji; Shohei Minami; R. Hashimoto et al. · 2022 · Nature Aging · DOI

Full title: SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

Authors: Shunya Tsuji; Shohei Minami; R. Hashimoto; Y. Konishi; Tatsuya Suzuki; Tamae Kondo; Miwa Sasai; Shiho Torii; C. Ono; Shintaro Shichinohe; Shintaro Sato; Masahiro Wakita; S. Okumura; Sosuke Nakano; T. Matsudaira; Tomonori Matsumoto; Shimpei Kawamoto; Masahiro Yamamoto; Tokiko Watanabe; Y. Matsuura; K. Takayama; Takeshi Kobayashi; T. Okamoto; E. Hara

Year: 2022

Venue: Nature Aging

DOI: https://doi.org/10.1038/s43587-022-00170-7

Paper Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters

Lou Delval; Aline Hantute-Ghesquier; V. Sencio et al. · 2023 · Nature Aging · DOI

Full title: Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters

Authors: Lou Delval; Aline Hantute-Ghesquier; V. Sencio; J. Flaman; C. Robil; Fabiola Silva Angulo; L. Lipskaia; Ozmen Çobanoğlu; Anne-Sophie Lacoste; Arnaud Machelart; A. Danneels; Mathieu Corbin; L. Deruyter; S. Heumel; T. Idziorek; K. Séron; F. Sauvé; Antonino Bongiovanni; V. Prévot; I. Wolowczuk; S. Belouzard; Jean-Michel Saliou; P. Gosset; D. Bernard; Y. Rouillé; S. Adnot; M. Duterque-Coquillaud; F. Trottein

Year: 2023

Venue: Nature Aging

DOI: https://doi.org/10.1038/s43587-023-00442-w

Paper IL-23R is a senescence-linked circulating and tissue biomarker of aging.

Carver, Chase M; Rodriguez, Sonia L; Atkinson, Elizabeth J et al. · 2025 · Nature aging · DOI

Full title: IL-23R is a senescence-linked circulating and tissue biomarker of aging.

Authors: Carver, Chase M; Rodriguez, Sonia L; Atkinson, Elizabeth J; Dosch, Andrew J; Asmussen, Niels C; Gomez, Paul T; Leitschuh, Ethan A; Espindola-Netto, Jair M; Jeganathan, Karthik B; Whaley, Madison G; Kamenecka, Theodore M; Baker, Darren J; Haak, Andrew J; LeBrasseur, Nathan K; Schafer, Marissa J

Year: 2025

Venue: Nature aging

DOI: https://doi.org/10.1038/s43587-024-00752-7

Paper Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome.

Gallage, Suchira; Irvine, Elaine E; Barragan Avila, Jose Efren et al. · 2024 · Nature aging · DOI

Full title: Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome.

Authors: Gallage, Suchira; Irvine, Elaine E; Barragan Avila, Jose Efren; Reen, Virinder; Pedroni, Silvia M A; Duran, Imanol; Ranvir, Vikas; Khadayate, Sanjay; Pombo, Joaquim; Brookes, Sharon; Heide, Danijela; Dharmalingham, Gopuraja; Choudhury, Agharul I; Singh, Indrabahadur; Herranz, Nicolás; Vernia, Santiago; Heikenwalder, Mathias; Gil, Jesús; Withers, Dominic J

Year: 2024

Venue: Nature aging

DOI: https://doi.org/10.1038/s43587-024-00695-z

Paper Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

Corina Amor; Inés Fernández-Maestre; Saria Chowdhury et al. · 2024 · Nature Aging · DOI

Full title: Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

Year: 2024

Venue: Nature Aging

DOI: https://theses.gla.ac.uk/82719/1/2021KiourtisPhD.pdf

Paper Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish

Maï, Mounir El; Bird, Malia; Allouche, Asma et al. · 2023 · Nature Aging · DOI

Full title: Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish

Authors: Maï, Mounir El; Bird, Malia; Allouche, Asma; Targen, Seniye; Şerifoğlu, Naz; Lopes-Bastos, Bruno; Guigonis, Jean‐Marie; Kang, Da; Pourcher, Thierry; Yue, Jia‐Xing; Ferreira, Miguel Godinho

Year: 2023

Venue: Nature Aging

DOI: https://doi.org/10.1038/s43587-023-00401-5

Paper DNA nanoparticles targeting FOXO4 selectively eliminate cigarette smoke-induced senescent lung fibroblasts

HAN, YAOPIN; Wu, Yixing; He, Binfeng et al. · 2023 · Nanoscale Advances · DOI

Full title: DNA nanoparticles targeting FOXO4 selectively eliminate cigarette smoke-induced senescent lung fibroblasts

Authors: HAN, YAOPIN; Wu, Yixing; He, Binfeng; Wu, Di; Hua, Jian-lan; Qian, Hang; Zhang, Jing

Year: 2023

Venue: Nanoscale Advances

DOI: https://doi.org/10.1039/d3na00547j

Paper In vitro study on effect of bardoxolone methyl on cisplatin-induced cellular senescence in human proximal tubular cells

Kurosaki, Yoshifumi; Imoto, Akemi; Kawakami, Fumitaka et al. · 2022 · Molecular and Cellular Biochemistry · DOI

Full title: In vitro study on effect of bardoxolone methyl on cisplatin-induced cellular senescence in human proximal tubular cells

Authors: Kurosaki, Yoshifumi; Imoto, Akemi; Kawakami, Fumitaka; Ouchi, Motoshi; Morita, Asuka; Yokoba, Masanori; Takenaka, Tsuneo; Ichikawa, Takafumi; Katagiri, Masato; Nielsen, Rikke; Ishii, Naohito

Year: 2022

Venue: Molecular and Cellular Biochemistry

DOI: https://doi.org/10.1007/s11010-021-04295-y

Paper Dormant cancer cells: programmed quiescence, senescence, or both?

Truskowski, Kevin; Amend, Sarah R.; Pienta, Kenneth J. · 2023 · Cancer and Metastasis Reviews · DOI

Full title: Dormant cancer cells: programmed quiescence, senescence, or both?

Authors: Truskowski, Kevin; Amend, Sarah R.; Pienta, Kenneth J.

Year: 2023

Venue: Cancer and Metastasis Reviews

DOI: https://doi.org/10.1007/s10555-022-10073-z

Paper Plasma dilution improves cognition and attenuates neuroinflammation in old mice.

Mehdipour, Melod; Mehdipour, Taha; Skinner, Colin M et al. · 2021 · GeroScience · DOI

Full title: Plasma dilution improves cognition and attenuates neuroinflammation in old mice.

Authors: Mehdipour, Melod; Mehdipour, Taha; Skinner, Colin M; Wong, Nathan; Liu, Chao; Chen, Chia-Chien; Jeon, Ok Hee; Zuo, Yi; Conboy, Michael J; Conboy, Irina M

Year: 2021

Venue: GeroScience

DOI: https://doi.org/10.1007/s11357-020-00297-8

Paper Senescence, regulators of alternative splicing and effects of trametinib treatment in progeroid syndromes.

Bramwell, Laura R; Harries, Lorna W · 2024 · GeroScience · DOI

Full title: Senescence, regulators of alternative splicing and effects of trametinib treatment in progeroid syndromes.

Authors: Bramwell, Laura R; Harries, Lorna W

Year: 2024

Venue: GeroScience

DOI: https://doi.org/10.1007/s11357-023-00933-z

Paper Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study

Fielding, Roger A.; Atkinson, Elizabeth J.; Aversa, Zaira et al. · 2022 · GeroScience · DOI

Full title: Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study

Authors: Fielding, Roger A.; Atkinson, Elizabeth J.; Aversa, Zaira; White, Thomas A.; Heeren, Amanda A.; Achenbach, Sara J.; Mielke, Michelle M.; Cummings, Steven R.; Pahor, Marco; Leeuwenburgh, Christiaan; LeBrasseur, Nathan K.

Year: 2022

Venue: GeroScience

DOI: https://doi.org/10.1007/s11357-022-00685-2

Paper Senolytic intervention improves cognition, metabolism, and adiposity in female APPNL−F/NL−F mice

Yimin Fang; M. R. Peck; Kathleen Quinn et al. · 2023 · bioRxiv · DOI

Full title: Senolytic intervention improves cognition, metabolism, and adiposity in female APPNL−F/NL−F mice

Authors: Yimin Fang; M. R. Peck; Kathleen Quinn; Jenelle E. Chapman; David Medina; S. McFadden; Andrzej Bartke; K. Hascup; Erin R. Hascup

Year: 2023

Venue: bioRxiv

DOI: https://doi.org/10.1007/s11357-024-01308-8

Paper Sexual dimorphic metabolic and cognitive responses of C57BL/6 mice to Fisetin or Dasatinib and quercetin cocktail oral treatment

Yimin Fang; David X. Medina; R. Stockwell et al. · 2021 · bioRxiv · DOI

Full title: Sexual dimorphic metabolic and cognitive responses of C57BL/6 mice to Fisetin or Dasatinib and quercetin cocktail oral treatment

Authors: Yimin Fang; David X. Medina; R. Stockwell; Samuel McFadden; Kathleen Quinn; M. R. Peck; A. Bartke; K. Hascup; Erin R. Hascup

Year: 2021

Venue: bioRxiv

DOI: https://doi.org/10.1007/s11357-023-00843-0

Paper The Interplay Between Autophagy and Senescence in Anthracycline Cardiotoxicity

Russo, Michele; Bono, Enrico; Ghigo, Alessandra · 2021 · Current Heart Failure Reports · DOI

Full title: The Interplay Between Autophagy and Senescence in Anthracycline Cardiotoxicity

Authors: Russo, Michele; Bono, Enrico; Ghigo, Alessandra

Year: 2021

Venue: Current Heart Failure Reports

DOI: https://doi.org/10.1007/s11897-021-00519-w

Paper Cerebromicrovascular senescence in vascular cognitive impairment: does accelerated microvascular aging accompany atherosclerosis?

Ungvari, Anna; Nyúl-Tóth, Ádám; Patai, Roland et al. · 2025 · GeroScience · DOI

Full title: Cerebromicrovascular senescence in vascular cognitive impairment: does accelerated microvascular aging accompany atherosclerosis?

Authors: Ungvari, Anna; Nyúl-Tóth, Ádám; Patai, Roland; Csik, Boglarka; Gulej, Rafal; Nagy, Dorina; Shanmugarama, Santny; Benyó, Zoltán; Kiss, Tamas; Ungvari, Zoltan; Csiszar, Anna

Year: 2025

Venue: GeroScience

DOI: https://doi.org/10.1007/s11357-025-01621-w

Paper The senescence-inhibitory p53 isoform Δ133p53α: enhancing cancer immunotherapy and exploring novel therapeutic approaches for senescence-associated diseases

Nakamichi, Shinji; Yamada, Leo; Roselle, Christopher et al. · 2025 · GeroScience · DOI

Full title: The senescence-inhibitory p53 isoform Δ133p53α: enhancing cancer immunotherapy and exploring novel therapeutic approaches for senescence-associated diseases

Authors: Nakamichi, Shinji; Yamada, Leo; Roselle, Christopher; Horikawa, Izumi; June, Carl H.; Harris, Curtis C.

Year: 2025

Venue: GeroScience

DOI: https://doi.org/10.1007/s11357-025-01819-y

Paper NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse populations

Driscoll, Monica; Sedore, Christine A.; Onken, Brian et al. · 2025 · GeroScience · DOI

Full title: NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse populations

Authors: Driscoll, Monica; Sedore, Christine A.; Onken, Brian; Coleman-Hulbert, Anna L; Johnson, Erik; Phillips, Patrick C.; Lithgow, Gordon J.

Year: 2025

Venue: GeroScience

DOI: https://doi.org/10.1007/s11357-025-01627-4

Paper The anti-senescence effect of D-β-hydroxybutyrate in Hutchinson-Gilford progeria syndrome involves progerin clearance by the activation of the AMPK-mTOR-autophagy pathway

Monterrubio-Ledezma, Feliciano; Salcido-Gómez, Ashley; Zavaleta-Vásquez, Tania Ivette et al. · 2025 · GeroScience · DOI

Full title: The anti-senescence effect of D-β-hydroxybutyrate in Hutchinson-Gilford progeria syndrome involves progerin clearance by the activation of the AMPK-mTOR-autophagy pathway

Authors: Monterrubio-Ledezma, Feliciano; Salcido-Gómez, Ashley; Zavaleta-Vásquez, Tania Ivette; Navarro‐García, Fernando; Cisneros, Bulmaro; Massieu, Lourdes

Year: 2025

Venue: GeroScience

DOI: https://doi.org/10.1007/s11357-024-01501-9

Paper Senotherapeutics in Malignant Brain Cancer Therapy.

Kaina, Bernd; Christmann, Markus · 2025 · Current oncology reports · DOI

Full title: Senotherapeutics in Malignant Brain Cancer Therapy.

Authors: Kaina, Bernd; Christmann, Markus

Year: 2025

Venue: Current oncology reports

DOI: https://doi.org/10.1007/s11912-025-01733-8

Paper Increased cellular senescence in doxorubicin-induced murine ovarian injury: effect of senolytics.

Gao, Yueyue; Wu, Tong; Tang, Xianan et al. · 2023 · GeroScience · DOI

Full title: Increased cellular senescence in doxorubicin-induced murine ovarian injury: effect of senolytics.

Authors: Gao, Yueyue; Wu, Tong; Tang, Xianan; Wen, Jingyi; Zhang, Yan; Zhang, Jinjin; Wang, Shixuan

Year: 2023

Venue: GeroScience

DOI: https://doi.org/10.1007/s11357-023-00728-2

Paper Targeted clearance of senescent cells alleviates alcohol-associated liver disease by restoring cellular function and immune balance.

Tian, Tian; Xue, Yuhua; Song, Zhewei et al. · 2025 · GeroScience · DOI

Full title: Targeted clearance of senescent cells alleviates alcohol-associated liver disease by restoring cellular function and immune balance.

Authors: Tian, Tian; Xue, Yuhua; Song, Zhewei; Jin-Smith, Brady; Barkin, Joshua; Ottallah, Melak; Mannan, Mahfuza; Zhirkova, Arina; Zhou, Daohong; Pi, Liya

Year: 2025

Venue: GeroScience

DOI: https://doi.org/10.1007/s11357-025-01952-8

Paper Cell Senescence in Lupus

Gao, Lin; Slack, Maria A.; McDavid, Andrew et al. · 2019 · Current Rheumatology Reports · DOI

Full title: Cell Senescence in Lupus

Authors: Gao, Lin; Slack, Maria A.; McDavid, Andrew; Anolik, Jennifer H.; Looney, R. John

Year: 2019

Venue: Current Rheumatology Reports

DOI: https://doi.org/10.1007/s11926-019-0800-6

Paper Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review

Amaya-Montoya, Mateo; Pérez-Londoño, Agustín; Guatibonza-García, Valentina et al. · 2020 · Advances in Therapy · DOI

Full title: Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review

Authors: Amaya-Montoya, Mateo; Pérez-Londoño, Agustín; Guatibonza-García, Valentina; Vargas-Villanueva, Andrea; Mendivil, Carlos O.

Year: 2020

Venue: Advances in Therapy

DOI: https://doi.org/10.1007/s12325-020-01287-0

Paper Cellular senescence in the aging and diseased kidney.

Valentijn, F A; Falke, L L; Nguyen, T Q et al. · 2018 · Journal of cell communication and signaling · DOI

Full title: Cellular senescence in the aging and diseased kidney.

Authors: Valentijn, F A; Falke, L L; Nguyen, T Q; Goldschmeding, Roel

Year: 2018

Venue: Journal of cell communication and signaling

DOI: https://doi.org/10.1007/s12079-017-0434-2

Paper Elimination of docetaxel-induced senescence attenuates malignant progression in RB1-deficient CRPC.

Su, Huilan; Huang, Liqun; Xia, Wenwen et al. · 2025 · Cellular oncology (Dordrecht, Netherlands) · DOI

Full title: Elimination of docetaxel-induced senescence attenuates malignant progression in RB1-deficient CRPC.

Authors: Su, Huilan; Huang, Liqun; Xia, Wenwen; Tang, Dean G; Zhou, Jianjun; Yang, Guosheng

Year: 2025

Venue: Cellular oncology (Dordrecht, Netherlands)

DOI: https://doi.org/10.1007/s13402-025-01126-w

Paper Senolytics: charting a new course or enhancing existing anti-tumor therapies?

Czajkowski, Konrad; Herbet, Mariola; Murias, Marek et al. · 2025 · Cellular oncology (Dordrecht, Netherlands) · DOI

Full title: Senolytics: charting a new course or enhancing existing anti-tumor therapies?

Authors: Czajkowski, Konrad; Herbet, Mariola; Murias, Marek; Piątkowska-Chmiel, Iwona

Year: 2025

Venue: Cellular oncology (Dordrecht, Netherlands)

DOI: https://doi.org/10.1007/s13402-024-01018-5

Paper A senolysis-targeting bioenergetic nanoplatform for diabetic wound healing

Zijun Zheng; Xuerong Wei; Ziwei Jiang et al. · 2025 · Advanced Composites and Hybrid Materials · DOI

Full title: A senolysis-targeting bioenergetic nanoplatform for diabetic wound healing

Authors: Zijun Zheng; Xuerong Wei; Ziwei Jiang; Daping Xie; Pengwei Shi; Jun Ma; Qiuyi Yu; Yufang He; Aizhong Pang; Jinyuan Zeng; Yanbin Gao; Chunming Wang; Lei Yang

Year: 2025

Venue: Advanced Composites and Hybrid Materials

DOI: https://doi.org/10.1007/s42114-025-01509-5

Paper Aging and tumors: a dynamic interaction

Zhang, Yudi; Zhu, Siqiang; Liu, Zhaodong et al. · 2025 · Discover Oncology · DOI

Full title: Aging and tumors: a dynamic interaction

Authors: Zhang, Yudi; Zhu, Siqiang; Liu, Zhaodong; Hu, Yonghao; Zhang, Yongjian; Shang, Liang; Li, Leping

Year: 2025

Venue: Discover Oncology

DOI: https://doi.org/10.1007/s12672-025-01808-9

Paper Talazoparib and radiation enhance the senolytic efficacy of venetoclax in therapy-induced senescent triple-negative breast cancer cells

Sultan Almudimeegh; M. Almutairi; Abrar Softah et al. · 2025 · Saudi Pharmaceutical Journal · DOI

Full title: Talazoparib and radiation enhance the senolytic efficacy of venetoclax in therapy-induced senescent triple-negative breast cancer cells

Authors: Sultan Almudimeegh; M. Almutairi; Abrar Softah; Khalid Alhazzani; Lama Binobaid; Musaad A. Alshammari; H. A. Sobeai; Tareq Saleh; M. Alotaibi; Ali R. Alhoshani

Year: 2025

Venue: Saudi Pharmaceutical Journal

DOI: https://doi.org/10.1007/s44446-025-00034-2

Paper Idiopathic Pulmonary Fibrosis, Today and Tomorrow: Certainties and New Therapeutic Horizons

Giulianelli, Giacomo; Cocconcelli, Elisabetta; Fiorentù, Giordano et al. · 2025 · Pulmonary Therapy · DOI

Full title: Idiopathic Pulmonary Fibrosis, Today and Tomorrow: Certainties and New Therapeutic Horizons

Authors: Giulianelli, Giacomo; Cocconcelli, Elisabetta; Fiorentù, Giordano; Bernardinello, Nicol; Balestro, Elisabetta; Spagnolo, Paolo

Year: 2025

Venue: Pulmonary Therapy

DOI: https://doi.org/10.1007/s41030-025-00296-0

Paper Repurposing Drugs for Diabetes Mellitus as Potential Pharmacological Treatments for Sarcopenia – A Narrative Review

Witham, Miles D.; Granic, Antoneta; Pearson, Ewan R. et al. · 2023 · Drugs & Aging · DOI

Full title: Repurposing Drugs for Diabetes Mellitus as Potential Pharmacological Treatments for Sarcopenia – A Narrative Review

Authors: Witham, Miles D.; Granic, Antoneta; Pearson, Ewan R.; Robinson, Siân; Sayer, Avan Aihie

Year: 2023

Venue: Drugs & Aging

DOI: https://doi.org/10.1007/s40266-023-01042-4

Paper Pharmacotherapies in Older Adults with COPD: Challenges and Opportunities.

Matera, Maria Gabriella; Hanania, Nicola A; Maniscalco, Mauro et al. · 2023 · Drugs & aging · DOI

Full title: Pharmacotherapies in Older Adults with COPD: Challenges and Opportunities.

Authors: Matera, Maria Gabriella; Hanania, Nicola A; Maniscalco, Mauro; Cazzola, Mario

Year: 2023

Venue: Drugs & aging

DOI: https://doi.org/10.1007/s40266-023-01038-0

Paper Human proximal tubular epithelial cell interleukin-1 receptor signalling triggers G2/M arrest and cellular senescence during hypoxic kidney injury.

Giuliani, Kurt T K; Nag, Purba; Adams, Benjamin C et al. · 2025 · Cell death & disease · DOI

Full title: Human proximal tubular epithelial cell interleukin-1 receptor signalling triggers G2/M arrest and cellular senescence during hypoxic kidney injury.

Authors: Giuliani, Kurt T K; Nag, Purba; Adams, Benjamin C; Wang, Xiangju; Hong, Seokchan; Grivei, Anca; Johnston, Rebecca L; Waddell, Nicola; Ho, Kenneth K C; Tian, Yilin; Khan, Muhammad Ali; Kim, Chang Seong; Ng, Monica S Y; Gobe, Glenda; Ungerer, Jacobus P J; Forbes, Josephine M; Healy, Helen G; Kassianos, Andrew J

Year: 2025

Venue: Cell death & disease

DOI: https://doi.org/10.1038/s41419-025-07386-6

Paper Monovalent ions and stress-induced senescence in human mesenchymal endometrial stem/stromal cells

Shatrova, Alla; Burova, Elena; Pugovkina, Natalja et al. · 2022 · Scientific Reports · DOI

Full title: Monovalent ions and stress-induced senescence in human mesenchymal endometrial stem/stromal cells

Authors: Shatrova, Alla; Burova, Elena; Pugovkina, Natalja; Домнина, А. П.; Nikolsky, Nikolaj; Marakhova, I I

Year: 2022

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-022-15490-2

Paper In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers

Parinya Samakkarnthai; D. Saul; Lei Zhang et al. · 2023 · bioRxiv · DOI

Full title: In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers

Authors: Parinya Samakkarnthai; D. Saul; Lei Zhang; Zaira Aversa; Madison L. Doolittle; J. Sfeir; Japneet Kaur; Elizabeth J. Atkinson; James R. Edwards; R. G. G. Russell; R. Pignolo; James L Kirkland; T. Tchkonia; L. Niedernhofer; D. Monroe; N. LeBrasseur; J. Farr; Paul D. Robbins; Sundeep Khosla

Year: 2023

Venue: bioRxiv

DOI: https://doi.org/10.1101/2023.02.23.529777

Paper Senescence in Vascular Smooth Muscle Cells and Atherosclerosis

Zha, Yiwen; Zhuang, Wenwen; Yang, Yongqi et al. · 2022 · Frontiers in Cardiovascular Medicine · DOI

Full title: Senescence in Vascular Smooth Muscle Cells and Atherosclerosis

Authors: Zha, Yiwen; Zhuang, Wenwen; Yang, Yongqi; Zhou, Yue; Li, Hongliang; Liang, Jingyan

Year: 2022

Venue: Frontiers in Cardiovascular Medicine

DOI: https://doi.org/10.3389/fcvm.2022.910580

Paper Fisetin Attenuated Oxidative Stress-Induced Cellular Damage in ARPE-19 Human Retinal Pigment Epithelial Cells Through Nrf2-Mediated Activation of Heme Oxygenase-1

Park, Cheol; Noh, Jeong Sook; Jung, Youngmi et al. · 2022 · Frontiers in Pharmacology · DOI

Full title: Fisetin Attenuated Oxidative Stress-Induced Cellular Damage in ARPE-19 Human Retinal Pigment Epithelial Cells Through Nrf2-Mediated Activation of Heme Oxygenase-1

Authors: Park, Cheol; Noh, Jeong Sook; Jung, Youngmi; Leem, Sun‐Hee; Hyun, Jin Won; Chang, Young‐Chae; Kwon, Taeg Kyu; Kim, Gi‐Young; Lee, Hyesook; Choi, Yung Hyun

Year: 2022

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2022.927898

Thesis Novel insights into protein synthesis rates in the brain following two lifespan-extending treatments

Reid, Justin, author; Hamilton, Karyn, advisor; Miller, Benjamin, advisor et al. · 2018 · Colorado State University · DOI

Full title: Novel insights into protein synthesis rates in the brain following two lifespan-extending treatments

Authors: Reid, Justin, author; Hamilton, Karyn, advisor; Miller, Benjamin, advisor; Tsunoda, Susan, committee member

Year: 2018

Venue: Colorado State University

DOI: https://hdl.handle.net/10217/191325

Thesis A study on the systemic transmission of cellular senescence and its role in acute liver failure

Kiourtis, Christos · 2021 · University of Glasgow · DOI

Full title: A study on the systemic transmission of cellular senescence and its role in acute liver failure

Authors: Kiourtis, Christos

Year: 2021

Venue: University of Glasgow

Thesis Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects.

Strong, Randy; Miller, Richard A; Bogue, Molly et al. · 2020 · University of Cambridge · DOI

Full title: Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects.

Authors: Strong, Randy; Miller, Richard A; Bogue, Molly; Fernandez, Elizabeth; Javors, Martin A; Libert, Sergiy; Marinez, Paul Anthony; Murphy, Michael P; Musi, Nicolas; Nelson, James F; Petrascheck, Michael; Reifsnyder, Peter; Richardson, Arlan; Salmon, Adam B; Macchiarini, Francesca; Harrison, David E

Year: 2020

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/312679

Thesis Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk.

Cassidy, Liam D; Young, Andrew RJ; Young, Christopher NJ et al. · 2019 · University of Cambridge · DOI

Full title: Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk.

Authors: Cassidy, Liam D; Young, Andrew RJ; Young, Christopher NJ; Soilleux, Elizabeth J; Fielder, Edward; Weigand, Bettina M; Lagnado, Anthony; Brais, Rebecca; Ktistakis, Nicholas T; Wiggins, Kimberley A; Pyrillou, Katerina; Clarke, Murray CH; Jurk, Diana; Passos, Joao F; Narita, Masashi

Year: 2019

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/300207

Thesis Basic research: Killing the old: cell senescence in atherosclerosis

Bennett, MR; Clarke, MCH · 2017 · University of Cambridge · DOI

Full title: Basic research: Killing the old: cell senescence in atherosclerosis

Authors: Bennett, MR; Clarke, MCH

Year: 2017

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/262681

Thesis Targeting senescent cells in translational medicine.

Paez-Ribes, Marta; González-Gualda, Estela; Doherty, Gary J et al. · 2019 · University of Cambridge · DOI

Full title: Targeting senescent cells in translational medicine.

Authors: Paez-Ribes, Marta; González-Gualda, Estela; Doherty, Gary J; Muñoz-Espín, Daniel

Year: 2019

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/300243

Thesis Latest Advances in Aging Research and Drug Discovery

Rubinsztein, David · 2019 · University of Cambridge · DOI

Full title: Latest Advances in Aging Research and Drug Discovery

Authors: Rubinsztein, David

Year: 2019

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/298873

Thesis SARS-CoV-2-induced senescence as a potential therapeutic target.

Denholm, Mary; Rintoul, Robert C; Muñoz-Espín, Daniel · 2022 · University of Cambridge · DOI

Full title: SARS-CoV-2-induced senescence as a potential therapeutic target.

Authors: Denholm, Mary; Rintoul, Robert C; Muñoz-Espín, Daniel

Year: 2022

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/339735

Thesis Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration

Delenko, J; Hyman, N; Chatterjee, PK et al. · 2025 · University of Cambridge · DOI

Full title: Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration

Authors: Delenko, J; Hyman, N; Chatterjee, PK; Safaric Tepes, P; Shih, AJ; Xue, X; Gurney, J; Baker, AG; Wei, C; Munoz Espin, D; Fruk, L; Gregersen, PK; Metz, CN

Year: 2025

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/385882

Thesis Brain Cell Senescence: A New Therapeutic Target for the Acute Treatment of Ischemic Stroke.

Baixauli-Martín, Júlia; Aliena-Valero, Alicia; Castelló-Ruiz, María et al. · 2023 · University of Cambridge · DOI

Full title: Brain Cell Senescence: A New Therapeutic Target for the Acute Treatment of Ischemic Stroke.

Authors: Baixauli-Martín, Júlia; Aliena-Valero, Alicia; Castelló-Ruiz, María; Burguete, María C; López-Morales, Mikahela A; Muñoz-Espín, Daniel; Torregrosa, Germán; Salom, Juan B

Year: 2023

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/362109

Thesis Improved Therapeutic Efficiency of Senescent Cell-specific, Galactose-Functionalized Micelle Nanocarriers

Fruk, Ljiljana; Baker, Andrew; Badri, Parshad et al. · 2024 · University of Cambridge · DOI

Full title: Improved Therapeutic Efficiency of Senescent Cell-specific, Galactose-Functionalized Micelle Nanocarriers

Authors: Fruk, Ljiljana; Baker, Andrew; Badri, Parshad; Ahmed, Ishtiaq; Esteoa-Fernandez, Alejandra; Munoz-Espin, Daniel

Year: 2024

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/377424

Thesis Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer.

Haston, Scott; Gonzalez-Gualda, Estela; Morsli, Samir et al. · 2023 · University of Cambridge · DOI

Full title: Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer.

Authors: Haston, Scott; Gonzalez-Gualda, Estela; Morsli, Samir; Ge, Jianfeng; Reen, Virinder; Calderwood, Alexander; Moutsopoulos, Ilias; Panousopoulos, Leonidas; Deletic, Polina; Carreno, Gabriela; Guiho, Romain; Manshaei, Saba; Gonzalez-Meljem, Jose Mario; Lim, Hui Yuan; Simpson, Daniel J; Birch, Jodie; Pallikonda, Husayn A; Chandra, Tamir; Macias, David; Doherty, Gary J; Rassl, Doris M; Rintoul, Robert C; Signore, Massimo; Mohorianu, Irina; Akbar, Arne N; Gil, Jesús; Muñoz-Espín, Daniel; Martinez-Barbera, Juan Pedro

Year: 2023

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/362100

Thesis Author Correction: Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog

Magkouta, Sophia; Veroutis, Dimitris; Papaspyropoulos, Angelos et al. · 2025 · University of Cambridge · DOI

Full title: Author Correction: Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog

Authors: Magkouta, Sophia; Veroutis, Dimitris; Papaspyropoulos, Angelos; Georgiou, Maria; Lougiakis, Nikolaos; Pippa, Natassa; Havaki, Sophia; Palaiologou, Anastasia; Thanos, Dimitris-Foivos; Kambas, Konstantinos; Lagopati, Nefeli; Boukos, Nikos; Pouli, Nicole; Marakos, Panagiotis; Kotsinas, Athanassios; Thanos, Dimitris; Evangelou, Konstantinos; Sampaziotis, Fotios; Tamvakopoulos, Constantin; Pispas, Stergios; Petty, Russell; Kotopoulos, Nicholas; Gorgoulis, Vassilis G.

Year: 2025

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/381668

Thesis Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog.

Magkouta, Sophia; Veroutis, Dimitris; Papaspyropoulos, Angelos et al. · 2025 · University of Cambridge · DOI

Full title: Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog.

Year: 2025

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/379233

Thesis Microdose lithium reduces cellular senescence in human astrocytes - a potential pharmacotherapy for COVID-19?

Andersen, Julie · 2020 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Microdose lithium reduces cellular senescence in human astrocytes - a potential pharmacotherapy for COVID-19?

Authors: Andersen, Julie

Year: 2020

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://infoscience.epfl.ch/handle/20.500.14299/200233

Thesis Effects of low-dose rapamycin on lymphoid organs of mice prone and resistant to accelerated senescence

Martins, Joilson de Oliveira · 2024 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Effects of low-dose rapamycin on lymphoid organs of mice prone and resistant to accelerated senescence

Authors: Martins, Joilson de Oliveira

Year: 2024

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.3389/fimmu.2024.1310505

Thesis cGAS-STING drives ageing-related inflammation and neurodegeneration

Gulen, Muhammet F.; Samson, Natasha; Keller, Alexander et al. · 2023 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: cGAS-STING drives ageing-related inflammation and neurodegeneration

Authors: Gulen, Muhammet F.; Samson, Natasha; Keller, Alexander; Schwabenland, Marius; Liu, Chong; Glueck, Selene; Thacker, Vivek V.; Favre, Lucie; Mangeat, Bastien; Kroese, Lona J.; Krimpenfort, Paul; Prinz, Marco; Ablasser, Andrea

Year: 2023

Venue: École polytechnique fédérale de Lausanne (EPFL)

Thesis Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial

Liu, Sophia; D'Amico, Davide; Shankland, Eric et al. · 2022 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial

Authors: Liu, Sophia; D'Amico, Davide; Shankland, Eric; Bhayana, Saakshi; Garcia, Jose M.; Aebischer, Patrick; Rinsch, Chris; Singh, Anurag; Marcinek, David J.

Year: 2022

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/184996

Thesis Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

D'Amico, Davide; Andreux, Penelope A.; Valdes, Pamela et al. · 2021 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Authors: D'Amico, Davide; Andreux, Penelope A.; Valdes, Pamela; Singh, Anurag; Rinsch, Chris; Auwerx, Johan

Year: 2021

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/180256

Thesis Mitophagy Activation by Urolithin A to Target Muscle Aging

Faitg, Julie; D'Amico, Davide; Rinsch, Chris et al. · 2024 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Mitophagy Activation by Urolithin A to Target Muscle Aging

Authors: Faitg, Julie; D'Amico, Davide; Rinsch, Chris; Singh, Anurag

Year: 2024

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/204141

Thesis Cellular senescence and iron dyshomeostasis in alzheimer’s disease

Masaldan, S; Belaidi, AA; Ayton, S et al. · 2019 · University of Melbourne · DOI

Full title: Cellular senescence and iron dyshomeostasis in alzheimer’s disease

Authors: Masaldan, S; Belaidi, AA; Ayton, S; Bush, AI

Year: 2019

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/230689

Thesis Harnessing senescence to control PI3K/AKT/mTORC pathway-driven cancer through the metabolic intervention

Zhu, Haoran · 2020 · University of Melbourne · DOI

Full title: Harnessing senescence to control PI3K/AKT/mTORC pathway-driven cancer through the metabolic intervention

Authors: Zhu, Haoran

Year: 2020

Venue: University of Melbourne

DOI: http://hdl.handle.net/11343/242063

Thesis Repurposing proteostasis-modifying drugs to prevent or treat age-related dementia: A systematic review

Heard, DS; Tuttle, CSL; Lautenschlager, NT et al. · 2020 · University of Melbourne · DOI

Full title: Repurposing proteostasis-modifying drugs to prevent or treat age-related dementia: A systematic review

Authors: Heard, DS; Tuttle, CSL; Lautenschlager, NT; Maier, AB

Year: 2020

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/253273

Thesis Ibrutinib protects T cells in patients with CLL from proliferation-induced senescence

Davis, JE; Sharpe, C; Mason, K et al. · 2022 · University of Melbourne · DOI

Full title: Ibrutinib protects T cells in patients with CLL from proliferation-induced senescence

Authors: Davis, JE; Sharpe, C; Mason, K; Tam, CS; Koldej, RM; Ritchie, DS

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/296338

Thesis Senescent Osteocytes: Do They Cause Damage and Can They Be Targeted to Preserve the Skeleton?

Sims, NA · 2021 · University of Melbourne · DOI

Full title: Senescent Osteocytes: Do They Cause Damage and Can They Be Targeted to Preserve the Skeleton?

Authors: Sims, NA

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/291823

Thesis Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions

Hajj-Boutros, G; Faust, A; Muscedere, J et al. · 2024 · University of Melbourne · DOI

Full title: Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions

Authors: Hajj-Boutros, G; Faust, A; Muscedere, J; Kim, P; Abumrad, N; Chevalier, S; Aubertin-Leheudre, M; Bergman, H; Bowdish, D; Burford, J; Carrington-Lawrence, S; Côté, H; Dawe, DE; Barreto, PDS; Farrelly, C; Fowler, R; Gouspillou, G; Harrington, L; Lautrup, S; Howlett, S; Imani, M; Kirkland, J; Kuchel, G; Mallette, FA; Morais, JA; Newman, JC; Pullman, D; Sierra, F; Van Raamsdonk, J; Watt, J; Rylett, RJ; Duque, G

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/353797

Thesis Targeting ageing with rapamycin and its derivatives in humans: a systematic review

Lee, DJW; Hodzic Kuerec, A; Maier, AB · 2024 · University of Melbourne · DOI

Full title: Targeting ageing with rapamycin and its derivatives in humans: a systematic review

Authors: Lee, DJW; Hodzic Kuerec, A; Maier, AB

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/351983

Thesis Senescence in the aging process.

Faragher, Richard Ga; McArdle, Anne; Willows, Alison et al. · 2017 · University of Liverpool · DOI

Full title: Senescence in the aging process.

Authors: Faragher, Richard Ga; McArdle, Anne; Willows, Alison; Ostler, Elizabeth L

Year: 2017

Venue: University of Liverpool

DOI: https://livrepository.liverpool.ac.uk/3018231/1/Senescence%20in%20the%20aging%20process.pdf

Thesis A Systems Biology Analysis of Cell Cycle Arrest Suggests that Modular Activation of Stress Responses Underlies Heterogeneous Cellular Senescence and Quiescence Phenotypes

Avelar, Roberto · 2023 · University of Liverpool · DOI

Full title: A Systems Biology Analysis of Cell Cycle Arrest Suggests that Modular Activation of Stress Responses Underlies Heterogeneous Cellular Senescence and Quiescence Phenotypes

Authors: Avelar, Roberto

Year: 2023

Venue: University of Liverpool

DOI: https://livrepository.liverpool.ac.uk/3173246/1/201329530_Jan2023.pdf

Thesis Il-10 Family Members as Novel Responders to Genotoxic Stress

Small, Sara · 2023 · University of Pennsylvania · DOI

Full title: Il-10 Family Members as Novel Responders to Genotoxic Stress

Authors: Small, Sara

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/28897

Thesis Induction of Cellular Senescence As A Novel Therapeutic Strategy for Melanoma Treatment

Zhang, Gao · 2023 · University of Pennsylvania · DOI

Full title: Induction of Cellular Senescence As A Novel Therapeutic Strategy for Melanoma Treatment

Authors: Zhang, Gao

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/32359

Thesis GENERATION OF NOVEL MOUSE MODELS FOR THE INVESTIGATION OF DIABETES THERAPEUTICS

Waite, Eric, Loring · 2025 · University of Pennsylvania · DOI

Full title: GENERATION OF NOVEL MOUSE MODELS FOR THE INVESTIGATION OF DIABETES THERAPEUTICS

Authors: Waite, Eric, Loring

Year: 2025

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/61256

Thesis Senolytic treatment with Navitoclax alters microglial phenotype and attenuates CNS immune-mediated demyelinating disease in a model of progressive Multiple Sclerosis

Dokiburra, Amy · 2025 · The Ohio State University · DOI

Full title: Senolytic treatment with Navitoclax alters microglial phenotype and attenuates CNS immune-mediated demyelinating disease in a model of progressive Multiple Sclerosis

Authors: Dokiburra, Amy

Year: 2025

Venue: The Ohio State University

DOI: https://kb.osu.edu/handle/1811/106051

Thesis Detection of senescence using machine learning algorithms based on nuclear features

Duran, Imanol; Pombo, Joaquim; Sun, Bin et al. · 2024 · Imperial College London · DOI

Full title: Detection of senescence using machine learning algorithms based on nuclear features

Authors: Duran, Imanol; Pombo, Joaquim; Sun, Bin; Gallage, Suchira; Kudo, Hiromi; McHugh, Domhnall; Bousset, Laura; Barragan Avila, Jose Efren; Forlano, Roberta; Manousou, Pinelopi; Heikenwalder, Mathias; Withers, Dominic J; Vernia, Santiago; Goldin, Robert D; Gil, Jesús

Year: 2024

Venue: Imperial College London

DOI: https://www.nature.com/articles/s41467-024-45421-w

Thesis Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome

Gallage, Suchira; Irvine, Elaine E; Barragan Avila, Jose Efren et al. · 2024 · Imperial College London · DOI

Full title: Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome

Authors: Gallage, Suchira; Irvine, Elaine E; Barragan Avila, Jose Efren; Reen, Virinder; Pedroni, Silvia MA; Duran, Imanol; Ranvir, Vikas; Khadayate, Sanjay; Pombo, Joaquim; Brookes, Sharon; Heide, Danijela; Dharmalingham, Gopuraja; Choudhury, Agharul I; Singh, Indrabahadur; Herranz, Nicolás; Vernia, Santiago; Heikenwalder, Mathias; Gil, Jesús; Withers, Dominic J

Year: 2024

Venue: Imperial College London

DOI: https://www.nature.com/articles/s43587-024-00695-z

Thesis Pharmacology of aging: Drosophila as a tool to validate drug targets for healthy lifespan

Dos Santos, Eliano; Cocheme, Helena · 2024 · Imperial College London · DOI

Full title: Pharmacology of aging: Drosophila as a tool to validate drug targets for healthy lifespan

Authors: Dos Santos, Eliano; Cocheme, Helena

Year: 2024

Venue: Imperial College London

DOI: https://agingcelljournal.org/Archive/Volume2/20240034/

Thesis Characterisation of premature cell senescence in Alzheimer's disease using single nuclear transcriptomics

Fancy, Nurun N; Smith, Amy M; Caramello, Alessia et al. · 2024 · Imperial College London · DOI

Full title: Characterisation of premature cell senescence in Alzheimer's disease using single nuclear transcriptomics

Authors: Fancy, Nurun N; Smith, Amy M; Caramello, Alessia; Tsartsalis, Stergios; Davey, Karen; Muirhead, Robert CJ; Mcgarry, Aisling; Jenkyns, Marion H; Schneegans, Eleonore; Chau, Vicky; Thomas, Michael; Boulger, Sam; Cheung, To Ka Dorcas; Adair, Emily; Papageorgopoulou, Marianna; Willumsen, Nanet; Khozoie, Combiz; Gomez-Nicola, Diego; Jackson, Johanna S; Matthews, Paul M

Year: 2024

Venue: Imperial College London

DOI: https://link.springer.com/article/10.1007/s00401-024-02727-9

Thesis Therapy-induced senescence contributes to the efficacy of abemaciclib in patients with dedifferentiated liposarcoma

Gleason, Caroline E.; Dickson, Mark A.; Klein, Mary E. (Dooley) et al. · 2024 · Nanyang Technological University (NTU) · DOI

Full title: Therapy-induced senescence contributes to the efficacy of abemaciclib in patients with dedifferentiated liposarcoma

Authors: Gleason, Caroline E.; Dickson, Mark A.; Klein, Mary E. (Dooley); Antonescu, Cristina R.; Gularte-Mérida, Rodrigo; Benitez, Marimar; Delgado, Juliana I.; Kataru, Raghu P.; Tan, Mark Wei Yi; Bradic, Martina; Adamson, Travis E.; Seier, Kenneth; Richards, Allison L.; Palafox, Marta; Chan, Eric; D'Angelo, Sandra P.; Gounder, Mrinal M.; Keohan, Mary Louise; Kelly, Ciara M.; Chi, Ping; Movva, Sujana; Landa, Jonathan; Crago, Aimee M.; Donoghue, Mark T. A.; Qin, Li-Xuan; Serra, Violetta; Turkekul, Mesruh; Barlas, Afsar; Firester, Daniel M.; Manova-Todorova, Katia; Mehrara, Babak J.; Kovatcheva, Marta; Tan, Nguan Soon; Singer, Samuel; Tap, William D.; Koff, Andrew

Year: 2024

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/180081

Thesis CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage

Raats, DAE; Frenkel, Nicola; van Schelven, Susanne J et al. · 2017 · Utrecht University · DOI

Full title: CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage

Authors: Raats, DAE; Frenkel, Nicola; van Schelven, Susanne J; Borel Rinkes, IHM; Laoukili, Jamila; Kranenburg, OW

Year: 2017

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/349531

Thesis Cellular Senescence and the Kidney: Potential Therapeutic Targets and Tools

Knoppert, Sebastiaan N; Valentijn, Floris A; Nguyen, Tri Q et al. · 2019 · Utrecht University · DOI

Full title: Cellular Senescence and the Kidney: Potential Therapeutic Targets and Tools

Authors: Knoppert, Sebastiaan N; Valentijn, Floris A; Nguyen, Tri Q; Goldschmeding, Roel; Falke, Lucas L

Year: 2019

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/392031

Thesis Cellular senescence in the aging and diseased kidney

Valentijn, F A; Falke, L L; Nguyen, T Q et al. · 2018 · Utrecht University · DOI

Full title: Cellular senescence in the aging and diseased kidney

Authors: Valentijn, F A; Falke, L L; Nguyen, T Q; Goldschmeding, Roel

Year: 2018

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/366570

Thesis The Uremic Toxin Indoxyl Sulfate Accelerates Senescence in Kidney Proximal Tubule Cells

Yang, Yi; Mihajlovic, Milos; Janssen, Manoe J. et al. · 2023 · Utrecht University · DOI

Full title: The Uremic Toxin Indoxyl Sulfate Accelerates Senescence in Kidney Proximal Tubule Cells

Authors: Yang, Yi; Mihajlovic, Milos; Janssen, Manoe J.; Masereeuw, Rosalinde

Year: 2023

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/427965

Thesis Acute Kidney Injury is Aggravated in Aged Mice by the Exacerbation of Proinflammatory Processes

Marquez-Exposito, Laura; Tejedor-Santamaria, Lucia; Santos-Sanchez, Laura et al. · 2021 · Utrecht University · DOI

Full title: Acute Kidney Injury is Aggravated in Aged Mice by the Exacerbation of Proinflammatory Processes

Authors: Marquez-Exposito, Laura; Tejedor-Santamaria, Lucia; Santos-Sanchez, Laura; Valentijn, Floris A.; Cantero-Navarro, Elena; Rayego-Mateos, Sandra; Rodrigues-Diez, Raul R.; Tejera-Muñoz, Antonio; Marchant, Vanessa; Sanz, Ana B.; Ortiz, Alberto; Goldschmeding, Roel; Ruiz-Ortega, Marta

Year: 2021

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/443201

Thesis **Institution:** Utrecht University **Date:** 2022-12

Valentijn, Floris A; Knoppert, Sebastiaan N; Marquez-Exposito, Laura et al. · 2022 · Theses · DOI

Full title: **Institution:** Utrecht University **Date:** 2022-12

Authors: Valentijn, Floris A; Knoppert, Sebastiaan N; Marquez-Exposito, Laura; Rodrigues-Diez, Raúl R; Pissas, Georgios; Tang, Jiaqi; Tejedor-Santamaria, Lucia; Broekhuizen, Roel; Samarakoon, Rohan; Eleftheriadis, Theodoros; Goldschmeding, Roel; Nguyen, Tri Q; Ruiz-Ortega, Marta; Falke, Lucas L

Year: 2022

Venue: Theses

DOI: https://dspace.library.uu.nl/handle/1874/447977

Thesis Evaluation of Senescence and Its Prevention in Doxorubicin-Induced Cardiotoxicity Using Dynamic Engineered Heart Tissues

Linders, Annet N; Dias, Itamar B; Ovchinnikova, Ekaterina S et al. · 2023 · Utrecht University · DOI

Full title: Evaluation of Senescence and Its Prevention in Doxorubicin-Induced Cardiotoxicity Using Dynamic Engineered Heart Tissues

Authors: Linders, Annet N; Dias, Itamar B; Ovchinnikova, Ekaterina S; Vermeer, Mathilde C S C; Hoes, Martijn F; Markousis Mavrogenis, George; Deiman, Frederik E; Arevalo Gomez, Karla F; Bliley, Jacqueline M; Nehme, Jamil; Vink, Aryan; Gietema, Jourik; de Boer, Rudolf A; Westenbrink, Daan; Sillje, Herman H W; Hilfiker-Kleiner, Denise; van Laake, Linda W; Feinberg, Adam W; Demaria, Marco; Bomer, Nils; van der Meer, Peter

Year: 2023

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/449527

Thesis Are immunosenescent T cells really senescent?

Slaets, Helena; Veeningen, Naomi; de Keizer, Peter L.J. et al. · 2024 · Utrecht University · DOI

Full title: Are immunosenescent T cells really senescent?

Authors: Slaets, Helena; Veeningen, Naomi; de Keizer, Peter L.J.; Hellings, Niels; Hendrix, Sven

Year: 2024

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/458080

Thesis Identified senescence endotypes in aged cartilage are reflected in the blood metabolome

Boone, Ilja; Tuerlings, Margo; Coutinho de Almeida, Rodrigo et al. · 2024 · Utrecht University · DOI

Full title: Identified senescence endotypes in aged cartilage are reflected in the blood metabolome

Authors: Boone, Ilja; Tuerlings, Margo; Coutinho de Almeida, Rodrigo; Lehmann, Johannes; Ramos, Yolande; Nelissen, Rob; Slagboom, Eline; de Keizer, Peter; Meulenbelt, Ingrid

Year: 2024

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/454491

Thesis Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors

Meharena, Hiruy S; Marco, Asaf; Dileep, Vishnu et al. · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors

Authors: Meharena, Hiruy S; Marco, Asaf; Dileep, Vishnu; Lockshin, Elana R; Akatsu, Grace Y; Mullahoo, James; Watson, L Ashley; Ko, Tak; Guerin, Lindsey N; Abdurrob, Fatema; Rengarajan, Shruthi; Papanastasiou, Malvina; Jaffe, Jacob D; Tsai, Li-Huei

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/150412

Thesis A Human Conditionally Immortalized Proximal Tubule Epithelial Cell Line as a Novel Model for Studying Senescence and Response to Senolytics

Yang, Yi; Mihajlovic, Milos; Valentijn, Floris et al. · 2022 · Utrecht University · DOI

Full title: A Human Conditionally Immortalized Proximal Tubule Epithelial Cell Line as a Novel Model for Studying Senescence and Response to Senolytics

Authors: Yang, Yi; Mihajlovic, Milos; Valentijn, Floris; Nguyen, Tri Q; Goldschmeding, Roel; Masereeuw, Rosalinde

Year: 2022

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/447974

Thesis A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses

Bent, Eric H; Gilbert, Luke Andrew; Hemann, Michael · 2017 · Massachusetts Institute of Technology (MIT) · DOI

Full title: A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses

Authors: Bent, Eric H; Gilbert, Luke Andrew; Hemann, Michael

Year: 2017

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/107125

Thesis Development of Reliable and High-Throughput Human Biomimetic Cartilage and Bone Models to Explore Senescence and Personalized Osteoarthritis Treatment Options

Boone, Ilja; Houtman, Evelyn; Tuerlings, Margo et al. · 2025 · Utrecht University · DOI

Full title: Development of Reliable and High-Throughput Human Biomimetic Cartilage and Bone Models to Explore Senescence and Personalized Osteoarthritis Treatment Options

Authors: Boone, Ilja; Houtman, Evelyn; Tuerlings, Margo; van den Berg, Jim J.; Lehmann, Johannes; de Keizer, Peter L.J.; Nelissen, Rob G.H.H.; Meulenbelt, Ingrid

Year: 2025

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/460850

Thesis Frataxin deficiency promotes endothelial senescence in pulmonary hypertension

None · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Frataxin deficiency promotes endothelial senescence in pulmonary hypertension

Authors: None

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/156923

Thesis Modulating senescent mesenchymal stromal cells via engineered culture environments

Gresham, Robert Charles Henry · 2023 · University of California, Davis · DOI

Full title: Modulating senescent mesenchymal stromal cells via engineered culture environments

Authors: Gresham, Robert Charles Henry

Year: 2023

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/9158w98c

Thesis Early Vascular Ageing and Cellular Senescence in Chronic Kidney Disease.

Lu Dai (528895); Abdul Rashid Qureshi (18685561); Anna Witasp (18669688) et al. · 2019 · Karolinska Institutet · DOI

Full title: Early Vascular Ageing and Cellular Senescence in Chronic Kidney Disease.

Authors: Lu Dai (528895); Abdul Rashid Qureshi (18685561); Anna Witasp (18669688); Bengt Lindholm (18685564); Peter Stenvinkel (18690619)

Year: 2019

Venue: Karolinska Institutet

DOI: oai:figshare.com:article/27303888

Thesis The Role of Cancer Associated Fibroblasts in Bone Invasive Oral Squamous Cell Carcinoma

Elmusrati, Areeg · 2020 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: The Role of Cancer Associated Fibroblasts in Bone Invasive Oral Squamous Cell Carcinoma

Authors: Elmusrati, Areeg

Year: 2020

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/26185/1/The%20Role%20of%20Cancer%20Associated%20Fibroblasts%20in%20Bone%20Invasive%20Oral%20Squamous%20Cell%20Carcinoma.pdf

Thesis The cause of cellular senescence and its prevention /

Huang, Ru Chih Cheo · 1960 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: The cause of cellular senescence and its prevention /

Authors: Huang, Ru Chih Cheo

Year: 1960

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486478251460497

Thesis Ageing and inflammation with focus on end-stage renal diseases : genetic and epigenetic factors

Karin Luttropp (18669652) · 2016 · Karolinska Institutet · DOI

Full title: Ageing and inflammation with focus on end-stage renal diseases : genetic and epigenetic factors

Authors: Karin Luttropp (18669652)

Year: 2016

Venue: Karolinska Institutet

DOI: oai:figshare.com:article/26920840

Thesis Investigating drug effects on aging and alzheimer's disease using causal inference approaches

Bowen Tang (18683428) · 2025 · Karolinska Institutet · DOI

Full title: Investigating drug effects on aging and alzheimer's disease using causal inference approaches

Authors: Bowen Tang (18683428)

Year: 2025

Venue: Karolinska Institutet

DOI: oai:figshare.com:article/27889941

Thesis Molecular insights into Hutchinson-Gilford progeria syndrome and age-associated disease : from mechanisms to treatment strategy

Gwladys Revêchon (18684808) · 2019 · Karolinska Institutet · DOI

Full title: Molecular insights into Hutchinson-Gilford progeria syndrome and age-associated disease : from mechanisms to treatment strategy

Authors: Gwladys Revêchon (18684808)

Year: 2019

Venue: Karolinska Institutet

DOI: oai:figshare.com:article/26924191

Thesis Senolytika - současný stav

Sekáč, Dávid · 2018 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Senolytika - současný stav

Authors: Sekáč, Dávid

Year: 2018

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/101588

Thesis Buněčná senescence a její vliv na terapeutickou rezistenci nádorových buněk

Levandrovskaia, Mariia · 2025 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Buněčná senescence a její vliv na terapeutickou rezistenci nádorových buněk

Authors: Levandrovskaia, Mariia

Year: 2025

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/199425

Thesis Vliv mitochondriálně cílených senolytických látek na rozvoj respiračních onemocnění

Rennerová, Michaela · 2024 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Vliv mitochondriálně cílených senolytických látek na rozvoj respiračních onemocnění

Authors: Rennerová, Michaela

Year: 2024

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/190186

Thesis Senescence-associated secretory phenotype regulated by mTOR pathway in senescent cells

Maslyaeva, Sofya · 2024 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Senescence-associated secretory phenotype regulated by mTOR pathway in senescent cells

Authors: Maslyaeva, Sofya

Year: 2024

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/190109

Thesis Prevention of cellular aging in vitro

Kubovčák, Matej · 2023 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Prevention of cellular aging in vitro

Authors: Kubovčák, Matej

Year: 2023

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/181315

Thesis Dual role of senescent cells in carcinogenesis and regulation of their secretome using senomorphic agents.

Franců, Andrea · 2025 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Dual role of senescent cells in carcinogenesis and regulation of their secretome using senomorphic agents.

Authors: Franců, Andrea

Year: 2025

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/199474

Thesis Úloha buněčné senescence v karcinogenezi a stárnutí mozku

Paroubková, Michaela · 2021 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Úloha buněčné senescence v karcinogenezi a stárnutí mozku

Authors: Paroubková, Michaela

Year: 2021

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/109815

Thesis Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia

Poisson, Johanne; Daskalaki, Ioanna; Potluri, Vijay et al. · 2025 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia

Authors: Poisson, Johanne; Daskalaki, Ioanna; Potluri, Vijay; Morel, Jean David; Rodriguez-Lopez, Sandra; De Masi, Alessia; Benegiamo, Giorgia; Jain, Suresh; Lima, Tanes; Auwerx, Johan

Year: 2025

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/242701

Thesis Understanding and targeting senescence in kidney disease

Chanvillard, Lucie; Mason, Thomas G.; Ferenbach, David A. · 2025 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Understanding and targeting senescence in kidney disease

Authors: Chanvillard, Lucie; Mason, Thomas G.; Ferenbach, David A.

Year: 2025

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/252196

Thesis Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice

Zumerle, Sara; Sarill, Miles; Saponaro, Miriam et al. · 2025 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice

Authors: Zumerle, Sara; Sarill, Miles; Saponaro, Miriam; Colucci, Manuel; Contu, Liliana; Lazzarini, Edoardo; Sartori, Roberta; Pezzini, Camilla; Rinaldi, Anna; Scanu, Anna; Sgrignani, Jacopo; Locatelli, Patrizia; Sabbadin, Marianna; Valdata, Aurora; Brina, Daniela; Giacomini, Isabella; Rizzo, Beatrice; Pierantoni, Alessandra; Sharifi, Saman; Bressan, Silvia; Altomare, Claudia; Goshovska, Yulia; Giraudo, Chiara; Luisetto, Roberto; Iaccarino, Luca; Torcasio, Cristina; Mosole, Simone; Pasquini, Emiliano; Rinaldi, Andrea; Pellegrini, Laura; Peron, Gregorio; Fassan, Matteo; Masiero, Stefano; Giori, Andrea Maria; Dall’Acqua, Stefano; Auwerx, Johan; Cippà, Pietro; Cavalli, Andrea; Bolis, Marco; Sandri, Marco; Barile, Lucio; Montopoli, Monica; Alimonti, Andrea

Year: 2025

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/243480

Thesis Pharmacological activation of Glucose-6-Phosphate Dehydrogenase (G6PD) to extend lifespan

Wong, Ashley · 2019 · UNSW Sydney · DOI

Full title: Pharmacological activation of Glucose-6-Phosphate Dehydrogenase (G6PD) to extend lifespan

Authors: Wong, Ashley

Year: 2019

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/64204

Thesis COX2 regulates senescence secretome composition and senescence surveillance through PGE2.

Gonçalves, Susana; Yin, Kelvin; Ito, Yoko et al. · 2021 · University of Cambridge · DOI

Full title: COX2 regulates senescence secretome composition and senescence surveillance through PGE2.

Authors: Gonçalves, Susana; Yin, Kelvin; Ito, Yoko; Chan, Adelyne; Olan, Ioana; Gough, Sarah; Cassidy, Liam; Serrao, Eva; Smith, Stephen; Young, Andrew; Narita, Masashi; Hoare, Matthew

Year: 2021

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/316758

Thesis Indocyanine Green J-aggregate Nanoparticles for Detection of Senescent Cells

Baker, Andrew · 2023 · University of Cambridge · DOI

Full title: Indocyanine Green J-aggregate Nanoparticles for Detection of Senescent Cells

Authors: Baker, Andrew

Year: 2023

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/354212

Thesis Premature cell senescence promotes vascular smooth muscle cell phenotypic modulation and resistance to re-differentiation

Bennett, Martin · 2025 · University of Cambridge · DOI

Full title: Premature cell senescence promotes vascular smooth muscle cell phenotypic modulation and resistance to re-differentiation

Authors: Bennett, Martin

Year: 2025

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/382718

Thesis Safety and therapeutical efficacy of the anti-ageing protein klotho for treating age-associated deficits and increasing longevity

Roig Soriano, Joan · 2024 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Safety and therapeutical efficacy of the anti-ageing protein klotho for treating age-associated deficits and increasing longevity

Authors: Roig Soriano, Joan

Year: 2024

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/690938

Thesis Mitochondrial Priming and Anti-Apoptotic Dependencies in Aging and Diseased Bone Marrow

Hogdal, Leah Justine · 2015 · Harvard University - DASH · DOI

Full title: Mitochondrial Priming and Anti-Apoptotic Dependencies in Aging and Diseased Bone Marrow

Authors: Hogdal, Leah Justine

Year: 2015

Venue: Harvard University - DASH

DOI: http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467490

Thesis Protection and repair of the ischemic heart

Koudstaal, S. · 2014 · Theses · DOI

Full title: Protection and repair of the ischemic heart

Authors: Koudstaal, S.

Year: 2014

Venue: Theses

DOI: https://dspace.library.uu.nl/handle/1874/291504

Thesis Insights into protein-bound uremic toxins in proximal tubule cell senescence and kidney fibrosis

Yang, Yi · 2023 · Utrecht University · DOI

Full title: Insights into protein-bound uremic toxins in proximal tubule cell senescence and kidney fibrosis

Authors: Yang, Yi

Year: 2023

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/432654

Thesis Senescence as a steppingstone for cancer treatment: If you stop, you might fall

Jochems, Fleur · 2023 · Utrecht University · DOI

Full title: Senescence as a steppingstone for cancer treatment: If you stop, you might fall

Authors: Jochems, Fleur

Year: 2023

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/432096

Thesis Senescent cell accumulation & Research-based undergraduate education

Valentijn, Floris Arnold · 2022 · Utrecht University · DOI

Full title: Senescent cell accumulation & Research-based undergraduate education

Authors: Valentijn, Floris Arnold

Year: 2022

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/422809

Thesis Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology

Roth-Walter, F.; Adcock, I. M.; Benito-Villalvilla, C. et al. · 2024 · Utrecht University · DOI

Full title: Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology

Authors: Roth-Walter, F.; Adcock, I. M.; Benito-Villalvilla, C.; Bianchini, R.; Bjermer, L.; Caramori, G.; Cari, L.; Chung, K. F.; Diamant, Z.; Eguiluz-Gracia, I.; Knol, E. F.; Jesenak, M.; Levi-Schaffer, F.; Nocentini, G.; O'Mahony, L.; Palomares, O.; Redegeld, F.; Sokolowska, M.; Van Esch, B. C.A.M.; Stellato, C.

Year: 2024

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/452455

Thesis The impacts of endothelial cell senescence on ageing-related blood-brain barrier dysfunction and the potential therapeutic strategies

Ya, Jingyuan · 2025 · University of Nottingham · DOI

Full title: The impacts of endothelial cell senescence on ageing-related blood-brain barrier dysfunction and the potential therapeutic strategies

Authors: Ya, Jingyuan

Year: 2025

Venue: University of Nottingham

DOI: https://eprints.nottingham.ac.uk/80866/1/Corrected%20according%20to%20examiners%27%20comments-PhD%20thesis_Jingyuan%20Ya_University%20of%20Nottingham_20306985.pdf

Thesis Visualizing Senolytic Drug-Regulated Metabolic Changes in Aging Drosophila using Multimodal Microscopy

Hussain, Sahran · 2023 · University of California, San Diego (UCSD) · DOI

Full title: Visualizing Senolytic Drug-Regulated Metabolic Changes in Aging Drosophila using Multimodal Microscopy

Authors: Hussain, Sahran

Year: 2023

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/8zw6s4gs

Thesis Profiling and Targeting Surface Biomarkers in Cellular Senescence, Hypoxic PDAC, MEKi-Treated Melanoma, and Antigen-Presenting Cells

Rettko, Nicholas Joseph · 2022 · University of California, San Francisco (UCSF) · DOI

Full title: Profiling and Targeting Surface Biomarkers in Cellular Senescence, Hypoxic PDAC, MEKi-Treated Melanoma, and Antigen-Presenting Cells

Authors: Rettko, Nicholas Joseph

Year: 2022

Venue: University of California, San Francisco (UCSF)

DOI: https://escholarship.org/uc/item/06c6g0bf

Thesis Insights into Epithelial Cell Senescence from Transcriptome and Secretome Analysis of Human Oral Keratinocytes

Schwartz, Rachael Ellen · 2021 · University of California, San Diego (UCSD) · DOI

Full title: Insights into Epithelial Cell Senescence from Transcriptome and Secretome Analysis of Human Oral Keratinocytes

Authors: Schwartz, Rachael Ellen

Year: 2021

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/23b6m57v

Thesis TERT-dependent senescence and inflammation in ageing, using zebrafish as a model

Martins, Raquel · 2020 · Theses · DOI

Full title: TERT-dependent senescence and inflammation in ageing, using zebrafish as a model

Authors: Martins, Raquel

Year: 2020

Venue: Theses

DOI: https://etheses.whiterose.ac.uk/id/eprint/27790/1/PhD%20thesis_Raquel%20Martins_161014804.pdf

Thesis Modulating the senescent and secretory phenotypes of fibroblasts using ultrasound

Alharbi, Amani · 2024 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Modulating the senescent and secretory phenotypes of fibroblasts using ultrasound

Authors: Alharbi, Amani

Year: 2024

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/34600/1/Alharbi%2C%20Amani%20180125629_.pdf

Thesis The molecular mechanisms driving chronic macrophage dysfunction in ageing

Moss, Charlotte Emily · 2024 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: The molecular mechanisms driving chronic macrophage dysfunction in ageing

Authors: Moss, Charlotte Emily

Year: 2024

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/34890/2/Moss%2C%20Charlotte%2C%20200203539_corrections.pdf

Thesis Activation and regulation of cell death in senescent cancer cells.

Holíček, Peter · 2021 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Activation and regulation of cell death in senescent cancer cells.

Authors: Holíček, Peter

Year: 2021

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/102160

Thesis ErbB inhibitors as a potential future treatment for chronic obstructive pulmonary disease

Herman, Kimberly Dana · 2022 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: ErbB inhibitors as a potential future treatment for chronic obstructive pulmonary disease

Authors: Herman, Kimberly Dana

Year: 2022

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/30753/1/Kimberly%20Herman%20Thesis.pdf

Thesis Activation of the Anaphase Promoting Complex as a Possible Treatment Strategy for Hutchinson Gilford Progeria Syndrome

Martinez Molina, Valeria CAROLINA · 2023 · University of Saskatchewan - HARVEST · DOI

Full title: Activation of the Anaphase Promoting Complex as a Possible Treatment Strategy for Hutchinson Gilford Progeria Syndrome

Authors: Martinez Molina, Valeria CAROLINA

Year: 2023

Venue: University of Saskatchewan - HARVEST

DOI: https://hdl.handle.net/10388/14688

Thesis DNA damage and signalling pathways in cellular senescence

Hubáčková, Soňa · 2019 · Charles University Prague (Univerzita Karlova) · DOI

Full title: DNA damage and signalling pathways in cellular senescence

Authors: Hubáčková, Soňa

Year: 2019

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/61088

Thesis Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

Romani, Mario · 2021 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

Authors: Romani, Mario

Year: 2021

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/175117

Thesis Stem cells, scaffolds and small molecules for orthopedic tissue regeneration

Jeon, Okhee · 2017 · Theses · DOI

Full title: Stem cells, scaffolds and small molecules for orthopedic tissue regeneration

Authors: Jeon, Okhee

Year: 2017

Venue: Theses

DOI: http://jhir.library.jhu.edu/handle/1774.2/40869

Thesis Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances

Jiang, Q; Liu, J; Huang, S et al. · 2025 · University of Melbourne · DOI

Full title: Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances

Authors: Jiang, Q; Liu, J; Huang, S; Wang, XY; Chen, X; Liu, GH; Ye, K; Song, W; Masters, CL; Wang, J; Wang, YJ

Year: 2025

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/360219

Thesis Investigating the role of cellular senescence in skeletal muscle and sarcopenia

Shigdar, Shahjahan · 2021 · University of Liverpool · DOI

Full title: Investigating the role of cellular senescence in skeletal muscle and sarcopenia

Authors: Shigdar, Shahjahan

Year: 2021

Venue: University of Liverpool

DOI: https://livrepository.liverpool.ac.uk/3134929/1/200882238_Jan2021.pdf

Thesis Towards a Greater Understanding of Ageing within the Cardiovascular System: Unravelling the Impact of Doxorubicin-Induced Ageing in Cardiovascular Cells and the Therapeutic Potential of NRF2 Activation and Senolytics

Bentley, Robert · 2024 · University of Liverpool · DOI

Full title: Towards a Greater Understanding of Ageing within the Cardiovascular System: Unravelling the Impact of Doxorubicin-Induced Ageing in Cardiovascular Cells and the Therapeutic Potential of NRF2 Activation and Senolytics

Authors: Bentley, Robert

Year: 2024

Venue: University of Liverpool

DOI: https://livrepository.liverpool.ac.uk/3182189/1/200849854_Nov2023.pdf

Thesis Towards restoring the protein degradation pathway(s) in Hutchinson-Gilford progeria syndrome (HGPS)

Gabriel, Diana · 2019 · Technical University of Munich (TUM) · DOI

Full title: Towards restoring the protein degradation pathway(s) in Hutchinson-Gilford progeria syndrome (HGPS)

Authors: Gabriel, Diana

Year: 2019

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1310725

Thesis Antibody-mediated direct killing and senolytic capacity of two distinct anti-CD20 monoclonal antibodies in human diffuse large B-cell lymphoma cell lines

Sun, Xinxin · 2022 · Freie Universität Berlin (Refubium) · DOI

Full title: Antibody-mediated direct killing and senolytic capacity of two distinct anti-CD20 monoclonal antibodies in human diffuse large B-cell lymphoma cell lines

Authors: Sun, Xinxin

Year: 2022

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/34667

Thesis Exploration of Novel Chemotypes that Ameliorate Cellular Senescence

Castellino, Nathan · 2024 · University of Sydney · DOI

Full title: Exploration of Novel Chemotypes that Ameliorate Cellular Senescence

Authors: Castellino, Nathan

Year: 2024

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/33482

Thesis Targeting lipids to regulate endothelial cell senescence

Han, Xingxing · 2023 · University of Sydney · DOI

Full title: Targeting lipids to regulate endothelial cell senescence

Authors: Han, Xingxing

Year: 2023

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/31816

Thesis Characterising senescence in iPSC-derived glial cells from amyotrophic lateral sclerosis patients expressing the C9orf72 mutation.

Maximova, Alexandra · 2024 · University of Sydney · DOI

Full title: Characterising senescence in iPSC-derived glial cells from amyotrophic lateral sclerosis patients expressing the C9orf72 mutation.

Authors: Maximova, Alexandra

Year: 2024

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/32841

Thesis COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells

McHugh, Domhnall; Sun, Bin; Gutierrez-Muñoz, Carmen et al. · 2023 · Imperial College London · DOI

Full title: COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells

Authors: McHugh, Domhnall; Sun, Bin; Gutierrez-Muñoz, Carmen; Hernández-González, Fernanda; Mellone, Massimiliano; Guiho, Romain; Duran, Imanol; Pombo, Joaquim; Pietrocola, Federico; Birch, Jodie; Kallemeijn, Wouter W; Khadayate, Sanjay; Dharmalingam, Gopuraja; Vernia, Santiago; Tate, Edward W; Martínez-Barbera, Juan Pedro; Withers, Dominic J; Thomas, Gareth J; Serrano, Manuel; Gil, Jesús

Year: 2023

Venue: Imperial College London

DOI: https://www.nature.com/articles/s41556-023-01287-6

Thesis The use of betaine as a novel senotherapy

Tran, Ngoc Uyen · 2025 · University of Glasgow · DOI

Full title: The use of betaine as a novel senotherapy

Authors: Tran, Ngoc Uyen

Year: 2025

Venue: University of Glasgow

DOI: https://theses.gla.ac.uk/85334/1/2025TranPhD.pdf

Thesis Le profil sécrétoire des macrophages sénescents est composé de vésicules extracellulaires enrichies en oncomiR

Bossé, Bianca · 2024 · Université de Montréal (Papyrus) · DOI

Full title: Le profil sécrétoire des macrophages sénescents est composé de vésicules extracellulaires enrichies en oncomiR

Authors: Bossé, Bianca

Year: 2024

Venue: Université de Montréal (Papyrus)

DOI: http://hdl.handle.net/1866/32665

Thesis Tumor Cell Senescence in Cancer Therapy

Liu, Yue · 2022 · University of Chicago - Knowledge@UChicago · DOI

Full title: Tumor Cell Senescence in Cancer Therapy

Authors: Liu, Yue

Year: 2022

Venue: University of Chicago - Knowledge@UChicago

DOI: https://knowledge.uchicago.edu/record/3664/files/Liu_uchicago_0330D_16186.pdf

Thesis Study of the role of the p16INK4a gene in tumor progression and tissue regeneration/function following exposure to ionizing radiation

Palacio, Lina · 2021 · Université de Montréal (Papyrus) · DOI

Full title: Study of the role of the p16INK4a gene in tumor progression and tissue regeneration/function following exposure to ionizing radiation

Authors: Palacio, Lina

Year: 2021

Venue: Université de Montréal (Papyrus)

DOI: http://hdl.handle.net/1866/24855

Thesis Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Revandkar, Ajinkya; Perciato, Maria Luna; Toso, Alberto et al. · 2017 · Theses · DOI

Full title: Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Authors: Revandkar, Ajinkya; Perciato, Maria Luna; Toso, Alberto; Alajati, Abdullah; Chen, Jingjing; Gerber, Hermeto; Dimitrov, Mitko; Rinaldi, Andrea; Delaleu, Nicolas; Pasquini, Emiliano; D'Antuono, Rocco; Pinton, Sandra; Losa, Marco; Gnetti, Letizia; Arribas, Alberto; Fraering, Patrick; Bertoni, Francesco; Nepveu, Alain; Alimonti, Andrea

Year: 2017

Venue: Theses

DOI: https://infoscience.epfl.ch/handle/20.500.14299/133527

Thesis Senolytic and mitogenic activities of Moringa oleifera Lam. leaf extract on culture expanded and doxorubicin oxidative stress-induced umbilical cord mesenchymal stem cells

Adamu, Muhammad Umar · 2022 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Senolytic and mitogenic activities of Moringa oleifera Lam. leaf extract on culture expanded and doxorubicin oxidative stress-induced umbilical cord mesenchymal stem cells

Authors: Adamu, Muhammad Umar

Year: 2022

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/116418/1/116418.pdf

Thesis REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks

Chatterjee, Nimrat; Whitman, Matthew A; Harris, Cynthia A et al. · 2021 · Massachusetts Institute of Technology (MIT) · DOI

Full title: REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks

Authors: Chatterjee, Nimrat; Whitman, Matthew A; Harris, Cynthia A; Min, Sophia M; Jonas, Oliver; Lien, Evan C; Luengo, Alba; Vander Heiden, Matthew G; Hong, Jiyong; Zhou, Pei; Hemann, Michael T; Walker, Graham C

Year: 2021

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/136057

Thesis Characterization Of Novel Nuclear Substrates Of Mammalian Autophagy Pathway In Cellular Senescence And Aging

Xu, Caiyue · 2023 · University of Pennsylvania · DOI

Full title: Characterization Of Novel Nuclear Substrates Of Mammalian Autophagy Pathway In Cellular Senescence And Aging

Authors: Xu, Caiyue

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/30644

Thesis Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis.

Ionescu, Rosana-Bristena; Nicaise, Alexandra M; Reisz, Julie A et al. · 2024 · University of Cambridge · DOI

Full title: Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis.

Authors: Ionescu, Rosana-Bristena; Nicaise, Alexandra M; Reisz, Julie A; Williams, Eleanor C; Prasad, Pranathi; Willis, Cory M; Simões-Abade, Madalena BC; Sbarro, Linda; Dzieciatkowska, Monika; Stephenson, Daniel; Suarez Cubero, Marta; Rizzi, Sandra; Pirvan, Liviu; Peruzzotti-Jametti, Luca; Fossati, Valentina; Edenhofer, Frank; Leonardi, Tommaso; Frezza, Christian; Mohorianu, Irina; D'Alessandro, Angelo; Pluchino, Stefano

Year: 2024

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/375465

Thesis Neuronal Reprogramming to Study Human Brain Aging and Disease

Herdy, Joseph · 2023 · University of California, San Diego (UCSD) · DOI

Full title: Neuronal Reprogramming to Study Human Brain Aging and Disease

Authors: Herdy, Joseph

Year: 2023

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/0g70b3nb

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Full title: us-10093675-b2

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Full title: us-10806764-b2

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Full title: us-10981892-b2

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· 2021

Full title: us-10905704-b2

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· 2020

Full title: us-10717722-b2

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Full title: us-11090320-b2

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Full title: us-11234993-b2

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Full title: us-11324764-b2

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· 2019

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Full title: us-2020056186-a1

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· 2020

Full title: us-2020123607-a1

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Full title: us-2020317640-a1

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· 2020

Full title: us-2020368264-a1

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· 2021

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· 2021

Full title: us-2021346412-a1

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· 2015

Full title: us-2015175548-a1

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Full title: us-12325688-b2

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Full title: us-2004131600-a1

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Full title: us-2010310508-a1

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Full title: us-2011152379-a1

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Full title: us-2015352064-a1

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Full title: us-10206896-b2

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Full title: us-6635642-b1

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Full title: us-6025194-a

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Full title: us-8697050-b2

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Paper Skeletal muscle performance and ageing

Tieland, Michael, Trouwborst, Inez, Clark, Brian C. · 2017 · Journal of Cachexia Sarcopenia and Muscle · DOI

Full title: Skeletal muscle performance and ageing

Authors: Tieland, Michael, Trouwborst, Inez, Clark, Brian C.

Year: 2017

Venue: Journal of Cachexia Sarcopenia and Muscle

DOI: https://doi.org/10.1002/jcsm.12238

Paper Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

Guo, Jun; Huang, Xiuqing; Dou, Lin et al. · 2022 · Signal Transduction and Targeted Therapy · DOI

Full title: Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

Authors: Guo, Jun; Huang, Xiuqing; Dou, Lin; Yan, Mingjing; Shen, Tao; Tang, Weiqing; Li, Jian

Year: 2022

Venue: Signal Transduction and Targeted Therapy

DOI: https://doi.org/10.1038/s41392-022-01251-0

Paper From discoveries in ageing research to therapeutics for healthy ageing

Campisi, Judith; Kapahi, Pankaj; Lithgow, Gordon J. et al. · 2019 · Nature · DOI

Full title: From discoveries in ageing research to therapeutics for healthy ageing

Authors: Campisi, Judith; Kapahi, Pankaj; Lithgow, Gordon J.; Melov, Simon; Newman, John C.; Verdin, Eric

Year: 2019

Venue: Nature

DOI: https://doi.org/10.1038/s41586-019-1365-2

Paper The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

Yamamoto, Masayuki, Kensler, Thomas W., Motohashi, Hozumi · 2018 · Physiological Reviews · DOI

Full title: The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

Authors: Yamamoto, Masayuki, Kensler, Thomas W., Motohashi, Hozumi

Year: 2018

Venue: Physiological Reviews

DOI: https://doi.org/10.1152/physrev.00023.2017

Paper Virus-Induced Membrane Fusion in Neurodegenerative Disorders

Osorio, Carolina; Sfera, Adonis; Anton, Jonathan J. et al. · 2022 · Frontiers in Cellular and Infection Microbiology · DOI

Full title: Virus-Induced Membrane Fusion in Neurodegenerative Disorders

Authors: Osorio, Carolina; Sfera, Adonis; Anton, Jonathan J.; Thomas, Karina G.; Andronescu, Christina V.; Li, Erica; Yahia, Rayan W.; Avalos, Andrea García; Kozlakidis, Zisis

Year: 2022

Venue: Frontiers in Cellular and Infection Microbiology

DOI: https://doi.org/10.3389/fcimb.2022.845580

Paper Potential Therapies to Protect the Aging Heart Against Ischemia/Reperfusion Injury

Díaz‐Vesga, Magda C.; Zúñiga-Cuevas, Úrsula; Ramírez-Reyes, Andrés et al. · 2021 · Frontiers in Cardiovascular Medicine · DOI

Full title: Potential Therapies to Protect the Aging Heart Against Ischemia/Reperfusion Injury

Authors: Díaz‐Vesga, Magda C.; Zúñiga-Cuevas, Úrsula; Ramírez-Reyes, Andrés; Herrera-Zelada, Nicolas; Palomo, Iván; Bravo, Roberto; Riquelme, Jaime A.

Year: 2021

Venue: Frontiers in Cardiovascular Medicine

DOI: https://doi.org/10.3389/fcvm.2021.770421

Paper Design of a Randomized Placebo-Controlled Trial to Evaluate the Anti-inflammatory and Senolytic Effects of Quercetin in Patients Undergoing Coronary Artery Bypass Graft Surgery.

Dagher, Olina; Mury, Pauline; Noly, Pierre-Emmanuel et al. · 2021 · Frontiers in cardiovascular medicine · DOI

Full title: Design of a Randomized Placebo-Controlled Trial to Evaluate the Anti-inflammatory and Senolytic Effects of Quercetin in Patients Undergoing Coronary Artery Bypass Graft Surgery.

Authors: Dagher, Olina; Mury, Pauline; Noly, Pierre-Emmanuel; Fortier, Annik; Lettre, Guillaume; Thorin, Eric; Carrier, Michel

Year: 2021

Venue: Frontiers in cardiovascular medicine

DOI: https://doi.org/10.3389/fcvm.2021.741542

Paper Cardiomyocytes Cellular Phenotypes After Myocardial Infarction

Lodrini, Alessandra Maria; Goumans, Marie‐José · 2021 · Frontiers in Cardiovascular Medicine · DOI

Full title: Cardiomyocytes Cellular Phenotypes After Myocardial Infarction

Authors: Lodrini, Alessandra Maria; Goumans, Marie‐José

Year: 2021

Venue: Frontiers in Cardiovascular Medicine

DOI: https://doi.org/10.3389/fcvm.2021.750510

Paper Metabolism and senescence in the immune microenvironment of osteosarcoma: focus on new therapeutic strategies

Ying, Hui; Li, Zhiqiang; Li, Meng-Pan et al. · 2023 · Frontiers in Endocrinology · DOI

Full title: Metabolism and senescence in the immune microenvironment of osteosarcoma: focus on new therapeutic strategies

Authors: Ying, Hui; Li, Zhiqiang; Li, Meng-Pan; Liu, Wencai

Year: 2023

Venue: Frontiers in Endocrinology

DOI: https://doi.org/10.3389/fendo.2023.1217669

Paper Pancreatic β-cell senescence in diabetes: mechanisms, markers and therapies

Cha, Jeeyeon; Aguayo‐Mazzucato, Cristina; Thompson, Peter J. · 2023 · Frontiers in Endocrinology · DOI

Full title: Pancreatic β-cell senescence in diabetes: mechanisms, markers and therapies

Authors: Cha, Jeeyeon; Aguayo‐Mazzucato, Cristina; Thompson, Peter J.

Year: 2023

Venue: Frontiers in Endocrinology

DOI: https://doi.org/10.3389/fendo.2023.1212716

Paper Cellular Senescence as the Pathogenic Hub of Diabetes-Related Wound Chronicity

Berlanga‐Acosta, Jorge; Guillén, Gerardo; Rodríguez-Rodríguez, Nadia et al. · 2020 · Frontiers in Endocrinology · DOI

Full title: Cellular Senescence as the Pathogenic Hub of Diabetes-Related Wound Chronicity

Authors: Berlanga‐Acosta, Jorge; Guillén, Gerardo; Rodríguez-Rodríguez, Nadia; Mendoza‐Marí, Yssel; Bringas-Vega, María L.; Berlanga-Saez, Jorge O.; Herrera, Diana García del Barco; Martínez-Jiménez, Indira; Hernandez-Gutierrez, Sandra; Valdés‐Sosa, Pedro A.

Year: 2020

Venue: Frontiers in Endocrinology

DOI: https://doi.org/10.3389/fendo.2020.573032

Paper Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies

Walcher, Lia; Kistenmacher, Ann-Kathrin; Suo, Huizhen et al. · 2020 · Frontiers in Immunology · DOI

Full title: Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies

Authors: Walcher, Lia; Kistenmacher, Ann-Kathrin; Suo, Huizhen; Kitte, Reni; Dluczek, Sarah; Strauß, Alexander; Blaudszun, André‐René; Yevsa, Tetyana; Fricke, Stephan; Kossatz-Boehlert, Uta

Year: 2020

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2020.01280

Paper Drugs against metabolic diseases as potential senotherapeutics for aging-related respiratory diseases.

Matsubayashi, Sachi; Ito, Saburo; Araya, Jun et al. · 2023 · Frontiers in endocrinology · DOI

Full title: Drugs against metabolic diseases as potential senotherapeutics for aging-related respiratory diseases.

Authors: Matsubayashi, Sachi; Ito, Saburo; Araya, Jun; Kuwano, Kazuyoshi

Year: 2023

Venue: Frontiers in endocrinology

DOI: https://doi.org/10.3389/fendo.2023.1079626

Paper Targeting Inflammation and Immunosenescence to Improve Vaccine Responses in the Elderly

Pereira, Branca; Xu, Xiao‐Ning; Akbar, Arne N. · 2020 · Frontiers in Immunology · DOI

Full title: Targeting Inflammation and Immunosenescence to Improve Vaccine Responses in the Elderly

Authors: Pereira, Branca; Xu, Xiao‐Ning; Akbar, Arne N.

Year: 2020

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2020.583019

Paper Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration

Tammaro, Alessandra; Kers, Jesper; Scantlebery, Angelique M. L. et al. · 2020 · Frontiers in Immunology · DOI

Full title: Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration

Authors: Tammaro, Alessandra; Kers, Jesper; Scantlebery, Angelique M. L.; Florquin, Sandrine

Year: 2020

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2020.01346

Paper Cellular senescence is a key mediator of lung aging and susceptibility to infection

Torrance, Blake L.; Haynes, Laura · 2022 · Frontiers in Immunology · DOI

Full title: Cellular senescence is a key mediator of lung aging and susceptibility to infection

Authors: Torrance, Blake L.; Haynes, Laura

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.1006710

Paper COVID-19 Immunobiology: Lessons Learned, New Questions Arise

Kaklamanos, Aimilios; Belogiannis, Konstantinos; Skendros, Panagiotis et al. · 2021 · Frontiers in Immunology · DOI

Full title: COVID-19 Immunobiology: Lessons Learned, New Questions Arise

Authors: Kaklamanos, Aimilios; Belogiannis, Konstantinos; Skendros, Panagiotis; Gorgoulis, Vassilis G.; Vlachoyiannopoulos, Panayiotis G.; Tzioufas, Athanasios G.

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.719023

Paper Senescence, NK cells, and cancer: navigating the crossroads of aging and disease

Gergues, Marina; Bari, Rafijul; Koppisetti, Sharmila et al. · 2025 · Frontiers in Immunology · DOI

Full title: Senescence, NK cells, and cancer: navigating the crossroads of aging and disease

Authors: Gergues, Marina; Bari, Rafijul; Koppisetti, Sharmila; Gosiewska, Anna; Kang, Lin; Hariri, Robert

Year: 2025

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2025.1565278

Paper Cellular senescence in brain aging and cognitive decline

Shafqat, Areez; Khan, Saifullah; Omer, Mohamed H. et al. · 2023 · Frontiers in Aging Neuroscience · DOI

Full title: Cellular senescence in brain aging and cognitive decline

Authors: Shafqat, Areez; Khan, Saifullah; Omer, Mohamed H.; Niaz, Mahnoor; Albalkhi, Ibrahem; Alkattan, Khaled; Yaqinuddin, Ahmed; Tchkonia, Tamar; Kirkland, James L.; Hashmi, Shahrukh K.

Year: 2023

Venue: Frontiers in Aging Neuroscience

DOI: https://doi.org/10.3389/fnagi.2023.1281581

Paper Senolytic and senomorphic secondary metabolites as therapeutic agents in Drosophila melanogaster models of Parkinson’s disease

Miller, Sean; Darji, Rayyan Y.; Walaieh, Sami et al. · 2023 · Frontiers in Neurology · DOI

Full title: Senolytic and senomorphic secondary metabolites as therapeutic agents in Drosophila melanogaster models of Parkinson’s disease

Authors: Miller, Sean; Darji, Rayyan Y.; Walaieh, Sami; Lewis, Jhemerial Arnique; Logan, Robert

Year: 2023

Venue: Frontiers in Neurology

DOI: https://doi.org/10.3389/fneur.2023.1271941

Paper Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances

Yu, Zuxiang; Xu, Chaoyu; Song, Bin et al. · 2023 · Journal of Translational Medicine · DOI

Full title: Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances

Authors: Yu, Zuxiang; Xu, Chaoyu; Song, Bin; Zhang, Shihao; Chen, Chong; Li, Changlong; Zhang, Shuyu

Year: 2023

Venue: Journal of Translational Medicine

DOI: https://doi.org/10.1186/s12967-023-04554-0

Paper Cellular senescence in cancer: clinical detection and prognostic implications

Domen, Andreas; Deben, Christophe; Verswyvel, Jasper et al. · 2022 · Journal of Experimental & Clinical Cancer Research · DOI

Full title: Cellular senescence in cancer: clinical detection and prognostic implications

Authors: Domen, Andreas; Deben, Christophe; Verswyvel, Jasper; Flieswasser, Tal; Prenen, Hans; Peeters, Marc; Lardon, Filip; Wouters, An

Year: 2022

Venue: Journal of Experimental & Clinical Cancer Research

DOI: https://doi.org/10.1186/s13046-022-02555-3

Paper Oligodendrocyte progenitor cells in Alzheimer’s disease: from physiology to pathology

Zou, Peibin; Wu, Chongyun; Liu, Timon Cheng‐Yi et al. · 2023 · Translational Neurodegeneration · DOI

Full title: Oligodendrocyte progenitor cells in Alzheimer’s disease: from physiology to pathology

Authors: Zou, Peibin; Wu, Chongyun; Liu, Timon Cheng‐Yi; Duan, Rui; Yang, Luodan

Year: 2023

Venue: Translational Neurodegeneration

DOI: https://doi.org/10.1186/s40035-023-00385-7

Paper The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing

Liu, Yuqing; Tan, Yejun; Zhang, Zheyu et al. · 2024 · Translational Neurodegeneration · DOI

Full title: The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing

Authors: Liu, Yuqing; Tan, Yejun; Zhang, Zheyu; Yi, Min; Zhu, Lemei; Peng, Weijun

Year: 2024

Venue: Translational Neurodegeneration

DOI: https://doi.org/10.1186/s40035-024-00397-x

Paper 12489 Senolytics Dasatinib And Quercetin Alleviate Type 1 Diabetes-Related Cardiac Fibrosis In Male Akita Ins-/+Mice

N. Kadoumi; G. Zatarah; J. Stokar et al. · 2024 · Journal of the Endocrine Society · DOI

Full title: 12489 Senolytics Dasatinib And Quercetin Alleviate Type 1 Diabetes-Related Cardiac Fibrosis In Male Akita Ins-/+Mice

Authors: N. Kadoumi; G. Zatarah; J. Stokar; P. Shivam; I. Gurt; R. Dresner‐Pollak

Year: 2024

Venue: Journal of the Endocrine Society

DOI: https://doi.org/10.1210/jendso/bvae163.927

Paper New Horizons: Novel Approaches to Enhance Healthspan Through Targeting Cellular Senescence and Related Aging Mechanisms.

Tchkonia, Tamar; Palmer, Allyson K; Kirkland, James L · 2021 · The Journal of clinical endocrinology and metabolism · DOI

Full title: New Horizons: Novel Approaches to Enhance Healthspan Through Targeting Cellular Senescence and Related Aging Mechanisms.

Authors: Tchkonia, Tamar; Palmer, Allyson K; Kirkland, James L

Year: 2021

Venue: The Journal of clinical endocrinology and metabolism

DOI: https://doi.org/10.1210/clinem/dgaa728

Paper Age-related Changes in the Adrenal Cortex: Insights and Implications

Warde, Kate; Smith, Lorenzo; Basham, Kaitlin J. · 2023 · Journal of the Endocrine Society · DOI

Full title: Age-related Changes in the Adrenal Cortex: Insights and Implications

Authors: Warde, Kate; Smith, Lorenzo; Basham, Kaitlin J.

Year: 2023

Venue: Journal of the Endocrine Society

DOI: https://doi.org/10.1210/jendso/bvad097

Paper A phase II randomized double-blind placebo-controlled study of fisetin to improve physical function in frail older breast cancer survivors (TROFFi).

Jingran Ji; Marie Bae; F. L. Wong et al. · 2024 · Journal of Clinical Oncology · DOI

Full title: A phase II randomized double-blind placebo-controlled study of fisetin to improve physical function in frail older breast cancer survivors (TROFFi).

Authors: Jingran Ji; Marie Bae; F. L. Wong; C. M. Crespi; Lisa D. Yee; Mina S. Sedrak

Year: 2024

Venue: Journal of Clinical Oncology

DOI: https://doi.org/10.1200/jco.2024.42.16_suppl.tps1645

Paper Targeting chemoresistant senescent pancreatic cancer cells improves conventional treatment efficacy

S. Jaber; Marine Warnier; Christopher Leers et al. · 2023 · Molecular Biomedicine · DOI

Full title: Targeting chemoresistant senescent pancreatic cancer cells improves conventional treatment efficacy

Authors: S. Jaber; Marine Warnier; Christopher Leers; Mathieu Vernier; D. Goehrig; Jean‐Jacques Médard; D. Vindrieux; Dorian V Ziegler; D. Bernard

Year: 2023

Venue: Molecular Biomedicine

DOI: https://doi.org/10.1186/s43556-023-00116-4

Paper Senolytics: Potential for Alleviating Diabetes and Its Complications

Allyson K. Palmer; T. Tchkonia; J. Kirkland · 2021 · Endocrinology · DOI

Full title: Senolytics: Potential for Alleviating Diabetes and Its Complications

Authors: Allyson K. Palmer; T. Tchkonia; J. Kirkland

Year: 2021

Venue: Endocrinology

DOI: https://doi.org/10.1210/endocr/bqab058

Paper A phase II randomized placebo-controlled study of fisetin and exercise to mitigate chemotherapy-related functional decline in postmenopausal women with early breast cancer (PROFFi).

Jingran Ji; Marla D Lipsyc-Sharf; Yuliya Zektser et al. · 2025 · Journal of Clinical Oncology · DOI

Full title: A phase II randomized placebo-controlled study of fisetin and exercise to mitigate chemotherapy-related functional decline in postmenopausal women with early breast cancer (PROFFi).

Authors: Jingran Ji; Marla D Lipsyc-Sharf; Yuliya Zektser; Kirsten K. Ness; Y. Abdou; Poorni Manohar; H. McArthur; Mylin A. Torres; George A. Kuchel; Arash Naeim; C. M. Crespi; Beverly Canin; Patricia Spears; Sandra Finestone; Ali Al Saleem; Joseph D. Olivera; Kelly S. Synold; L. Petersen; Hyman B Muss; Mina S. Sedrak

Year: 2025

Venue: Journal of Clinical Oncology

DOI: https://doi.org/10.1200/jco.2025.43.16_suppl.tps12148

Paper Potential Clinical Implications of Senotherapies for Cardiovascular Disease.

Suda, Masayoshi; Katsuumi, Goro; Tchkonia, Tamar et al. · 2024 · Circulation journal : official journal of the Japanese Circulation Society · DOI

Full title: Potential Clinical Implications of Senotherapies for Cardiovascular Disease.

Authors: Suda, Masayoshi; Katsuumi, Goro; Tchkonia, Tamar; Kirkland, James L; Minamino, Tohru

Year: 2024

Venue: Circulation journal : official journal of the Japanese Circulation Society

DOI: https://doi.org/10.1253/circj.CJ-23-0657

Paper Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction

M. Suda; Karl H Paul; Utkarsh Tripathi et al. · 2024 · Endocrine reviews · DOI

Full title: Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction

Authors: M. Suda; Karl H Paul; Utkarsh Tripathi; Tohru Minamino; T. Tchkonia; James L. Kirkland

Year: 2024

Venue: Endocrine reviews

DOI: https://doi.org/10.1210/endrev/bnae010

Paper A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers.

Torres, Pascual; Anerillas, Carlos; Ramírez-Núñez, Omar et al. · 2022 · Disease models & mechanisms · DOI

Full title: A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers.

Authors: Torres, Pascual; Anerillas, Carlos; Ramírez-Núñez, Omar; Fernàndez, Anna; Encinas, Mario; Povedano, Mònica; Andrés-Benito, Pol; Ferrer, Isidre; Ayala, Victòria; Pamplona, Reinald; Portero-Otín, Manuel

Year: 2022

Venue: Disease models & mechanisms

DOI: https://doi.org/10.1242/dmm.049059

Paper Translating the biology of aging into novel therapeutics for Alzheimer disease

Hara, Yuko; McKeehan, Nicholas; Fillit, Howard · 2018 · Neurology · DOI

Full title: Translating the biology of aging into novel therapeutics for Alzheimer disease

Authors: Hara, Yuko; McKeehan, Nicholas; Fillit, Howard

Year: 2018

Venue: Neurology

DOI: https://doi.org/10.1212/wnl.0000000000006745

Paper 7581 Periodic Administration of Quercetin and Dasatinib Alleviates Skeletal Fragility in the INS2AKITA Mouse Model of Type 1 Diabetes

· 2024 · Journal of the Endocrine Society · DOI

Full title: 7581 Periodic Administration of Quercetin and Dasatinib Alleviates Skeletal Fragility in the INS2AKITA Mouse Model of Type 1 Diabetes

Year: 2024

Venue: Journal of the Endocrine Society

DOI: https://doi.org/10.1210/jendso/bvae163.471

Paper CELL SENESCENCE AND SENOLYTIC TREATMENT FOR LOW BACK PAIN

Lisbet Haglund; Hosni Cherif; Saber Ghazizadeh et al. · 2025 · Orthopaedic Proceedings · DOI

Full title: CELL SENESCENCE AND SENOLYTIC TREATMENT FOR LOW BACK PAIN

Authors: Lisbet Haglund; Hosni Cherif; Saber Ghazizadeh; M. Mannarino; M. Millecamps; Jean A. Ouellet; Laura S Stone

Year: 2025

Venue: Orthopaedic Proceedings

DOI: https://doi.org/10.1302/1358-992x.2025.6.022

Paper Understanding Cellular Senescence and Senotherapeutics for Nutri-geriatric Solutions

Sonam Chawla; Sanjukta Bhattacharya; Aaysha Gupta · 2025 · Biomedical & Pharmacology Journal · DOI

Full title: Understanding Cellular Senescence and Senotherapeutics for Nutri-geriatric Solutions

Authors: Sonam Chawla; Sanjukta Bhattacharya; Aaysha Gupta

Year: 2025

Venue: Biomedical & Pharmacology Journal

DOI: https://doi.org/10.13005/bpj/3214

Paper Nurturing longevity through natural compounds: Where do we stand, and where do we go?

Todorova, Monika N.; Savova, Martina S.; Mihaylova, Liliya V. et al. · 2024 · Food Frontiers · DOI

Full title: Nurturing longevity through natural compounds: Where do we stand, and where do we go?

Authors: Todorova, Monika N.; Savova, Martina S.; Mihaylova, Liliya V.; Georgiev, Milen I.

Year: 2024

Venue: Food Frontiers

DOI: https://doi.org/10.1002/fft2.350

Paper A review of pathobiological mechanisms and potential application of medicinal plants for vascular aging: focus on endothelial cell senescence

Barinda, Agian Jeffilano; Arozal, Wawaimuli; Yuasa, Shinsuke · 2022 · Medical Journal of Indonesia · DOI

Full title: A review of pathobiological mechanisms and potential application of medicinal plants for vascular aging: focus on endothelial cell senescence

Authors: Barinda, Agian Jeffilano; Arozal, Wawaimuli; Yuasa, Shinsuke

Year: 2022

Venue: Medical Journal of Indonesia

DOI: https://doi.org/10.13181/mji.rev.226064

Paper Recent advances in the treatment of osteoarthritis

Grässel, Susanne; Muschter, Dominique · 2020 · F1000Research · DOI

Full title: Recent advances in the treatment of osteoarthritis

Authors: Grässel, Susanne; Muschter, Dominique

Year: 2020

Venue: F1000Research

DOI: https://doi.org/10.12688/f1000research.22115.1

Paper Translating the Biology of Aging into New Therapeutics for Alzheimer's Disease: Senolytics.

Riessland, M; Orr, M E · 2023 · The journal of prevention of Alzheimer's disease · DOI

Full title: Translating the Biology of Aging into New Therapeutics for Alzheimer's Disease: Senolytics.

Authors: Riessland, M; Orr, M E

Year: 2023

Venue: The journal of prevention of Alzheimer's disease

DOI: https://doi.org/10.14283/jpad.2023.104

Paper Aging, Senescence, and Dementia

Q. Behfar; A. Ramírez Zúñiga; Pamela V. Martino-Adami · 2022 · The journal of prevention of Alzheimer's disease · DOI

Full title: Aging, Senescence, and Dementia

Authors: Q. Behfar; A. Ramírez Zúñiga; Pamela V. Martino-Adami

Year: 2022

Venue: The journal of prevention of Alzheimer's disease

DOI: https://doi.org/10.14283/jpad.2022.42

Paper Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial.

Gonzales, M M; Garbarino, V R; Marques Zilli, E et al. · 2022 · The journal of prevention of Alzheimer's disease · DOI

Full title: Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial.

Authors: Gonzales, M M; Garbarino, V R; Marques Zilli, E; Petersen, R C; Kirkland, J L; Tchkonia, T; Musi, N; Seshadri, S; Craft, S; Orr, M E

Year: 2022

Venue: The journal of prevention of Alzheimer's disease

DOI: https://doi.org/10.14283/jpad.2021.62

Paper Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?

Kim, Chul-Kyu; Sachdev, Perminder S; Braidy, Nady · 2022 · Aging and Disease · DOI

Full title: Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?

Authors: Kim, Chul-Kyu; Sachdev, Perminder S; Braidy, Nady

Year: 2022

Venue: Aging and Disease

DOI: https://doi.org/10.14336/ad.2021.0705

Paper Identification of Novel Senescent Markers in Small Extracellular Vesicles

Tomoka Misawa; Kazuhiro Hitomi; K. Miyata et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: Identification of Novel Senescent Markers in Small Extracellular Vesicles

Authors: Tomoka Misawa; Kazuhiro Hitomi; K. Miyata; Yoko Tanaka; Risa Fujii; Masatomo Chiba; Tze Mun Loo; A. Hanyu; H. Kawasaki; Hisaya Kato; Y. Maezawa; K. Yokote; Asako J Nakamura; K. Ueda; N. Yaegashi; Akiko Takahashi

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms24032421

Paper Anti-Aging Effects of Anthocyanin Extracts of Sambucus canadensis Caused by Targeting Mitochondrial-Induced Oxidative Stress.

Hu, Xiaoqing; Yang, Yimeng; Tang, Shi et al. · 2023 · International journal of molecular sciences · DOI

Full title: Anti-Aging Effects of Anthocyanin Extracts of Sambucus canadensis Caused by Targeting Mitochondrial-Induced Oxidative Stress.

Authors: Hu, Xiaoqing; Yang, Yimeng; Tang, Shi; Chen, Qiuyan; Zhang, Meiyu; Ma, Jiaoyan; Qin, Jianchun; Yu, Huimei

Year: 2023

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms24021528

Paper Hematopoietic Stem Cells and the Immune System in Development and Aging

Shevyrev, Daniil; Tereshchenko, Valeriy; Berezina, Tatiana et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: Hematopoietic Stem Cells and the Immune System in Development and Aging

Authors: Shevyrev, Daniil; Tereshchenko, Valeriy; Berezina, Tatiana; Rybtsov, Stanislav

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms24065862

Paper New Senolysis Approach via Antibody–Drug Conjugate Targeting of the Senescent Cell Marker Apolipoprotein D for Skin Rejuvenation

Takaya, Kento; Asou, Toru; Kishi, Kazuo · 2023 · International Journal of Molecular Sciences · DOI

Full title: New Senolysis Approach via Antibody–Drug Conjugate Targeting of the Senescent Cell Marker Apolipoprotein D for Skin Rejuvenation

Authors: Takaya, Kento; Asou, Toru; Kishi, Kazuo

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms24065857

Paper Pro-Osteogenic and Anti-Inflammatory Synergistic Effect of Orthosilicic Acid, Vitamin K2, Curcumin, Polydatin and Quercetin Combination in Young and Senescent Bone Marrow-Derived Mesenchymal Stromal Cells

Giordani, Chiara; Matacchione, Giulia; Giuliani, Angelica et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: Pro-Osteogenic and Anti-Inflammatory Synergistic Effect of Orthosilicic Acid, Vitamin K2, Curcumin, Polydatin and Quercetin Combination in Young and Senescent Bone Marrow-Derived Mesenchymal Stromal Cells

Authors: Giordani, Chiara; Matacchione, Giulia; Giuliani, Angelica; Valli, Debora; Scarpa, Emanuele Salvatore; Antonelli, A.; Sabbatinelli, Jacopo; Giacchetti, Gilberta; Sabatelli, Sofia; Fabiola, Olivieri; Rippo, Maria Rita

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms24108820

Paper Cycloastragenol: A Novel Senolytic Agent That Induces Senescent Cell Apoptosis and Restores Physical Function in TBI-Aged Mice

Yang Zhang; Dongxiao Gao; Yang Yuan et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: Cycloastragenol: A Novel Senolytic Agent That Induces Senescent Cell Apoptosis and Restores Physical Function in TBI-Aged Mice

Authors: Yang Zhang; Dongxiao Gao; Yang Yuan; Runzi Zheng; Manting Sun; Shuting Jia; Jing Liu

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms24076554

Paper Skin Cancer Microenvironment: What We Can Learn from Skin Aging?

D’Arino, Andrea; Caputo, Silvia; Eibenschutz, Laura et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: Skin Cancer Microenvironment: What We Can Learn from Skin Aging?

Authors: D’Arino, Andrea; Caputo, Silvia; Eibenschutz, Laura; Piemonte, Paolo; Buccini, Pierluigi; Frascione, Pasquale; Bellei, Barbara

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms241814043

Paper Physiological Approaches Targeting Cellular and Mitochondrial Pathways Underlying Adipose Organ Senescence

Lange, Pieter de; Lombardi, Assunta; Silvestri, Elena et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: Physiological Approaches Targeting Cellular and Mitochondrial Pathways Underlying Adipose Organ Senescence

Authors: Lange, Pieter de; Lombardi, Assunta; Silvestri, Elena; Cioffi, Federica; Giacco, Antonia; Iervolino, Stefania; Petito, Giuseppe; Senese, Rosalba; Lanni, Antonia; Moreno, María

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms241411676

Paper Exploring the Communication of the SASP: Dynamic, Interactive, and Adaptive Effects on the Microenvironment

Giroud, Joëlle; Bouriez, Inès; Paulus, H. E. et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: Exploring the Communication of the SASP: Dynamic, Interactive, and Adaptive Effects on the Microenvironment

Authors: Giroud, Joëlle; Bouriez, Inès; Paulus, H. E.; Pourtier, Albin; Debacq‐Chainiaux, Florence; Pluquet, Olivier

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms241310788

Paper TMT-Based Proteomics Analysis of Senescent Nucleus Pulposus from Patients with Intervertebral Disc Degeneration

Zhang, Guangzhi; Li, Lei; Yang, Zhili et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: TMT-Based Proteomics Analysis of Senescent Nucleus Pulposus from Patients with Intervertebral Disc Degeneration

Authors: Zhang, Guangzhi; Li, Lei; Yang, Zhili; Zhang, Cangyu; Kang, Xuewen

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms241713236

Paper High-Tech Methods of Cytokine Imbalance Correction in Intervertebral Disc Degeneration

Shnayder, N. А.; Ashhotov, Azamat V.; Trefilova, Vera V. et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: High-Tech Methods of Cytokine Imbalance Correction in Intervertebral Disc Degeneration

Authors: Shnayder, N. А.; Ashhotov, Azamat V.; Trefilova, Vera V.; Novitsky, Maxim A.; Medvedev, German V.; Петрова, М. М.; Narodova, Ekaterina A.; Kaskaeva, Daria Sergeevna; Чумакова, Г. А.; Гарганеева, Н. П.; Ларева, Н. В.; Al-Zamil, Mustafa; Asadullin, Azat R.; Насырова, Р. Ф.

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms241713333

Paper Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies.

Ya, Jingyuan; Bayraktutan, Ulvi · 2023 · International journal of molecular sciences · DOI

Full title: Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies.

Authors: Ya, Jingyuan; Bayraktutan, Ulvi

Year: 2023

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms241411538

Paper Fisetin—In Search of Better Bioavailability—From Macro to Nano Modifications: A Review

Szymczak, Joanna; Cielecka‐Piontek, Judyta · 2023 · International Journal of Molecular Sciences · DOI

Full title: Fisetin—In Search of Better Bioavailability—From Macro to Nano Modifications: A Review

Authors: Szymczak, Joanna; Cielecka‐Piontek, Judyta

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms241814158

Paper In Vitro Models of Cell Senescence: A Systematic Review on Musculoskeletal Tissues and Cells

Veronesi, Francesca; Contartese, Deyanira; Sarno, Laura Di et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: In Vitro Models of Cell Senescence: A Systematic Review on Musculoskeletal Tissues and Cells

Authors: Veronesi, Francesca; Contartese, Deyanira; Sarno, Laura Di; Borsari, Veronica; Fini, Milena; Giavaresi, Gianluca

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms242115617

Paper Cells in Atherosclerosis: Focus on Cellular Senescence from Basic Science to Clinical Practice

Molnár, Andrea; Pásztor, Dorottya; Tarcza, Zsófia et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: Cells in Atherosclerosis: Focus on Cellular Senescence from Basic Science to Clinical Practice

Authors: Molnár, Andrea; Pásztor, Dorottya; Tarcza, Zsófia; Merkely, Béla

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms242417129

Paper Cellular Senescence: A Troy Horse in Pulmonary Fibrosis

Wan, Ruyan; Wang, Lan; Zhu, Miaomiao et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: Cellular Senescence: A Troy Horse in Pulmonary Fibrosis

Authors: Wan, Ruyan; Wang, Lan; Zhu, Miaomiao; Li, Wenwen; Duan, Yudi; Yu, Guoying

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms242216410

Paper Overview of Innate Immune Cell Landscape in Liver Aging

Lin, Yan; Li, Qiao; Liang, Guangyu et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: Overview of Innate Immune Cell Landscape in Liver Aging

Authors: Lin, Yan; Li, Qiao; Liang, Guangyu; Xiao, Nanyin; Yang, Jiankun; Yang, Xiao; Zhang, Heng; Zhang, Cuntai; Liu, Anding

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms25010181

Paper New Dawn for Atherosclerosis: Vascular Endothelial Cell Senescence and Death

Bu, Lan-Lan; Yuan, Huanhuan; Xie, Lingli et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: New Dawn for Atherosclerosis: Vascular Endothelial Cell Senescence and Death

Authors: Bu, Lan-Lan; Yuan, Huanhuan; Xie, Lingli; Guo, Min-Hua; Liao, Duan‐Fang; Zheng, Xi‐Long

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms242015160

Paper Inflammatory and Metabolic Signaling Interfaces of the Hypertrophic and Senescent Chondrocyte Phenotypes Associated with Osteoarthritis

Horváth, Emőke; Sólyom, Árpád; Székely, János et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: Inflammatory and Metabolic Signaling Interfaces of the Hypertrophic and Senescent Chondrocyte Phenotypes Associated with Osteoarthritis

Authors: Horváth, Emőke; Sólyom, Árpád; Székely, János; Nagy, E; Popoviciu, Horațiu

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms242216468

Paper Non-Genomic Hallmarks of Aging—The Review

Holmannová, Drahomíra; Borský, Pavel; Párová, Helena et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: Non-Genomic Hallmarks of Aging—The Review

Authors: Holmannová, Drahomíra; Borský, Pavel; Párová, Helena; Stverakova, Tereza; Vošmik, Milan; Hruška, Libor; Fiala, Zdeněk; Borská, Lenka

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms242015468

Paper Senotherapeutics to Counteract Senescent Cells Are Prominent Topics in the Context of Anti-Ageing Strategies

Anna Calabrò; G. Accardi; A. Aiello et al. · 2024 · International Journal of Molecular Sciences · DOI

Full title: Senotherapeutics to Counteract Senescent Cells Are Prominent Topics in the Context of Anti-Ageing Strategies

Authors: Anna Calabrò; G. Accardi; A. Aiello; Calogero Caruso; Damiano Galimberti; G. Candore

Year: 2024

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms25031792

Paper The Role of Cellular Senescence in Cyclophosphamide-Induced Primary Ovarian Insufficiency

Xu, Zixin; Takahashi, Nozomi; Harada, Miyuki et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: The Role of Cellular Senescence in Cyclophosphamide-Induced Primary Ovarian Insufficiency

Authors: Xu, Zixin; Takahashi, Nozomi; Harada, Miyuki; Kunitomi, Chisato; Kusamoto, Akari; Koike, Hiroshi; Tanaka, Tsurugi; Sakaguchi, Nanoka; Urata, Yoko; Wada‐Hiraike, Osamu; Hirota, Yasushi; Osuga, Yutaka

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms242417193

Paper The Plastic Interplay between Lung Regeneration Phenomena and Fibrotic Evolution: Current Challenges and Novel Therapeutic Perspectives

Lettieri, Sara; Bertuccio, Francesco Rocco; Frate, Lucia Del et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: The Plastic Interplay between Lung Regeneration Phenomena and Fibrotic Evolution: Current Challenges and Novel Therapeutic Perspectives

Authors: Lettieri, Sara; Bertuccio, Francesco Rocco; Frate, Lucia Del; Perrotta, Fabio; Corsico, Angelo Guido; Stella, Giulia Maria

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms25010547

Paper Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-Aging Strategies

Kitaeva, Kristina V.; Solovyeva, Valeriya V.; Blatt, Nataliya L. et al. · 2024 · International Journal of Molecular Sciences · DOI

Full title: Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-Aging Strategies

Authors: Kitaeva, Kristina V.; Solovyeva, Valeriya V.; Blatt, Nataliya L.; Rizvanov, Albert A.

Year: 2024

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms25010643

Paper Mechanochemical Approach to Obtaining a Multicomponent Fisetin Delivery System Improving Its Solubility and Biological Activity

Rosiak, Natalia; Tykarska, Ewa; Cielecka‐Piontek, Judyta · 2024 · International Journal of Molecular Sciences · DOI

Full title: Mechanochemical Approach to Obtaining a Multicomponent Fisetin Delivery System Improving Its Solubility and Biological Activity

Authors: Rosiak, Natalia; Tykarska, Ewa; Cielecka‐Piontek, Judyta

Year: 2024

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms25073648

Paper Cellular Senescence and Extracellular Vesicles in the Pathogenesis and Treatment of Obesity-A Narrative Review.

Liang, Yicong; Kaushal, Devesh; Wilson, Robert Beaumont · 2024 · International journal of molecular sciences · DOI

Full title: Cellular Senescence and Extracellular Vesicles in the Pathogenesis and Treatment of Obesity-A Narrative Review.

Authors: Liang, Yicong; Kaushal, Devesh; Wilson, Robert Beaumont

Year: 2024

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms25147943

Paper Spatio-Temporal Characterization of Cellular Senescence Hallmarks in Experimental Ischemic Stroke.

Baixauli-Martín, Júlia; Burguete, Maria Consuelo; López-Morales, Mikahela A et al. · 2025 · International journal of molecular sciences · DOI

Full title: Spatio-Temporal Characterization of Cellular Senescence Hallmarks in Experimental Ischemic Stroke.

Authors: Baixauli-Martín, Júlia; Burguete, Maria Consuelo; López-Morales, Mikahela A; Castelló-Ruiz, María; Aliena-Valero, Alicia; Jover-Mengual, Teresa; Falahatgaroshibi, Dianoush; Torregrosa, Germán; Salom, Juan B

Year: 2025

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms26052364

Paper The Potential of Naturally Derived Compounds for Treating Chronic Kidney Disease: A Review of Autophagy and Cellular Senescence

Teh, Yoong Mond; Mualif, Siti Aisyah; Noh, Nur Izzati Mohd et al. · 2024 · International Journal of Molecular Sciences · DOI

Full title: The Potential of Naturally Derived Compounds for Treating Chronic Kidney Disease: A Review of Autophagy and Cellular Senescence

Authors: Teh, Yoong Mond; Mualif, Siti Aisyah; Noh, Nur Izzati Mohd; Lim, Soo Kun

Year: 2024

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms26010003

Paper Endothelial Senescence: From Macro- to Micro-Vasculature and Its Implications on Cardiovascular Health

Wang, Peichun; Konja, Daniels; Singh, Sandeep et al. · 2024 · International Journal of Molecular Sciences · DOI

Full title: Endothelial Senescence: From Macro- to Micro-Vasculature and Its Implications on Cardiovascular Health

Authors: Wang, Peichun; Konja, Daniels; Singh, Sandeep; Zhang, Beijia; Wang, Yu

Year: 2024

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms25041978

Paper Senescence in Adipose-Derived Stem Cells: Biological Mechanisms and Therapeutic Challenges

Foti, Riccardo; Storti, Gabriele; Palmesano, Marco et al. · 2024 · International Journal of Molecular Sciences · DOI

Full title: Senescence in Adipose-Derived Stem Cells: Biological Mechanisms and Therapeutic Challenges

Authors: Foti, Riccardo; Storti, Gabriele; Palmesano, Marco; Scioli, Maria Giovanna; Fiorelli, Elena; Terriaca, Sonia; Cervelli, G; Kim, Bong‐Sung; Orlandi, Augusto; Cervelli, Valerio

Year: 2024

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms25158390

Paper The Differential Effect of Senolytics on SASP Cytokine Secretion and Regulation of EMT by CAFs

Daria A. Bogdanova; E. D. Kolosova; T. V. Pukhalskaia et al. · 2024 · International Journal of Molecular Sciences · DOI

Full title: The Differential Effect of Senolytics on SASP Cytokine Secretion and Regulation of EMT by CAFs

Authors: Daria A. Bogdanova; E. D. Kolosova; T. V. Pukhalskaia; K. A. Levchuk; O. N. Demidov; E. Belotserkovskaya

Year: 2024

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms25074031

Paper The Senescent Heart—“Age Doth Wither Its Infinite Variety”

Vijayakumar, Anupama; Wang, Mingyi; Kailasam, Shivakumar · 2024 · International Journal of Molecular Sciences · DOI

Full title: The Senescent Heart—“Age Doth Wither Its Infinite Variety”

Authors: Vijayakumar, Anupama; Wang, Mingyi; Kailasam, Shivakumar

Year: 2024

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms25073581

Paper Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects of Exercise.

Falvino, Angela; Bonanni, Roberto; Tarantino, Umberto et al. · 2025 · International journal of molecular sciences · DOI

Full title: Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects of Exercise.

Authors: Falvino, Angela; Bonanni, Roberto; Tarantino, Umberto; Tancredi, Virginia; Cariati, Ida

Year: 2025

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms26157573

Paper Cellular Senescence and Inflammaging in the Bone: Pathways, Genetics, Anti-Aging Strategies and Interventions.

Lawrence, Merin; Goyal, Abhishek; Pathak, Shelly et al. · 2024 · International journal of molecular sciences · DOI

Full title: Cellular Senescence and Inflammaging in the Bone: Pathways, Genetics, Anti-Aging Strategies and Interventions.

Authors: Lawrence, Merin; Goyal, Abhishek; Pathak, Shelly; Ganguly, Payal

Year: 2024

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms25137411

Paper Targeting Aging Hallmarks with Monoclonal Antibodies: A New Era in Cancer Immunotherapy and Geriatric Medicine.

Dal Bo, Michele; Gambirasi, Marta; Vruzhaj, Idris et al. · 2025 · International journal of molecular sciences · DOI

Full title: Targeting Aging Hallmarks with Monoclonal Antibodies: A New Era in Cancer Immunotherapy and Geriatric Medicine.

Authors: Dal Bo, Michele; Gambirasi, Marta; Vruzhaj, Idris; Cecchin, Erika; Pishdadian, Abbas; Toffoli, Giuseppe; Safa, Amin

Year: 2025

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms26114982

Paper Targeting Cellular Senescence with Liposome-Encapsulated Fisetin: Evidence of Senomorphic Effect

Agata Henschke; Bartosz F. Grześkowiak; Olena Ivashchenko et al. · 2025 · International Journal of Molecular Sciences · DOI

Full title: Targeting Cellular Senescence with Liposome-Encapsulated Fisetin: Evidence of Senomorphic Effect

Authors: Agata Henschke; Bartosz F. Grześkowiak; Olena Ivashchenko; M. C. Sánchez-Cerviño; E. Coy; Sergio Moya

Year: 2025

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms26157489

Paper Functional Features of Senescent Cells and Implications for Therapy.

Kirichenko, Tatiana V; Markina, Yuliya V; Markin, Alexander M et al. · 2025 · International journal of molecular sciences · DOI

Full title: Functional Features of Senescent Cells and Implications for Therapy.

Authors: Kirichenko, Tatiana V; Markina, Yuliya V; Markin, Alexander M; Vasilyev, Vyacheslav S; Hua, Huiming; Li, Dahong; Woo, Anthony Yiu-Ho; Deev, Roman V; Eremin, Ilya I; Kotenko, Konstantin V

Year: 2025

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms26115390

Paper Heterogeneity of Cellular Senescence, Senotyping, and Targeting by Senolytics and Senomorphics in Lung Diseases.

Ozdemir, Said Ali; Faizan, Md Imam; Kaur, Gagandeep et al. · 2025 · International journal of molecular sciences · DOI

Full title: Heterogeneity of Cellular Senescence, Senotyping, and Targeting by Senolytics and Senomorphics in Lung Diseases.

Authors: Ozdemir, Said Ali; Faizan, Md Imam; Kaur, Gagandeep; Shaikh, Sadiya Bi; Ul Islam, Khursheed; Rahman, Irfan

Year: 2025

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms26199687

Paper The Mechanistic Link Between Tau-Driven Proteotoxic Stress and Cellular Senescence in Alzheimer's Disease.

Tangavelou, Karthikeyan; Bhaskar, Kiran · 2024 · International journal of molecular sciences · DOI

Full title: The Mechanistic Link Between Tau-Driven Proteotoxic Stress and Cellular Senescence in Alzheimer's Disease.

Authors: Tangavelou, Karthikeyan; Bhaskar, Kiran

Year: 2024

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms252212335

Paper Effectiveness of PROTAC BET Degraders in Combating Cisplatin Resistance in Head and Neck Cancer Cells.

Luffman, Natalie; Ahmadinejad, Fereshteh; Finnegan, Ryan M et al. · 2025 · International journal of molecular sciences · DOI

Full title: Effectiveness of PROTAC BET Degraders in Combating Cisplatin Resistance in Head and Neck Cancer Cells.

Authors: Luffman, Natalie; Ahmadinejad, Fereshteh; Finnegan, Ryan M; Raymond, Marissa; Gewirtz, David A; Harada, Hisashi

Year: 2025

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms26136185

Paper Addition of Polyphenols to Drugs: The Potential of Controlling “Inflammaging” and Fibrosis in Human Senescent Lung Fibroblasts In Vitro

Maria Carolina Ximenes de Godoy; Gabriela Arruda Monteiro; Bárbara Hakim de Moraes et al. · 2024 · International Journal of Molecular Sciences · DOI

Full title: Addition of Polyphenols to Drugs: The Potential of Controlling “Inflammaging” and Fibrosis in Human Senescent Lung Fibroblasts In Vitro

Authors: Maria Carolina Ximenes de Godoy; Gabriela Arruda Monteiro; Bárbara Hakim de Moraes; Juliana Alves Macedo; Gisele Mara Silva Gonçalves; Alessandra Gambero

Year: 2024

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms25137163

Paper Rewinding the Clock: Emerging Pharmacological Strategies for Human Anti-Aging Therapy

Charlotte Delrue; R. Speeckaert; M. Speeckaert · 2025 · International Journal of Molecular Sciences · DOI

Full title: Rewinding the Clock: Emerging Pharmacological Strategies for Human Anti-Aging Therapy

Authors: Charlotte Delrue; R. Speeckaert; M. Speeckaert

Year: 2025

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms26199372

Paper Multi-Target Botanical Complex Attenuates Cellular Senescence via Bidirectional P21/P53/SIRT1 Regulation: Dual Model Validation.

Wu, Jiaqin; Dongzhu, Nanjia; Zhao, Chengzhou et al. · 2025 · International journal of molecular sciences · DOI

Full title: Multi-Target Botanical Complex Attenuates Cellular Senescence via Bidirectional P21/P53/SIRT1 Regulation: Dual Model Validation.

Authors: Wu, Jiaqin; Dongzhu, Nanjia; Zhao, Chengzhou; Liang, Jialin; Wang, Ningbo; Suonan, Dengdeng; Sun, Shengnan

Year: 2025

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms262311394

Paper Therapy-Induced Senescence (TIS) and SASP: The p53-Mediated Interplay in Cancer Progression and Treatment.

Lee, Chang Hoon; Minh Nguyen, Tuan; Lee, Yongook et al. · 2025 · International journal of molecular sciences · DOI

Full title: Therapy-Induced Senescence (TIS) and SASP: The p53-Mediated Interplay in Cancer Progression and Treatment.

Authors: Lee, Chang Hoon; Minh Nguyen, Tuan; Lee, Yongook; Choi, Seoung Gyu; Nguyen, Phuong Ngan; Park, Jung Ho; Park, Mi Kyung

Year: 2025

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms27010357

Paper Vascular Dementia: From Pathophysiology to Therapeutic Frontiers

Yang, Han‐Mo · 2025 · Journal of Clinical Medicine · DOI

Full title: Vascular Dementia: From Pathophysiology to Therapeutic Frontiers

Authors: Yang, Han‐Mo

Year: 2025

Venue: Journal of Clinical Medicine

DOI: https://doi.org/10.3390/jcm14186611

Paper Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro

Hosni Cherif; D. Bisson; P. Jarzem et al. · 2019 · Journal of Clinical Medicine · DOI

Full title: Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro

Authors: Hosni Cherif; D. Bisson; P. Jarzem; M. Weber; J. Ouellet; L. Haglund

Year: 2019

Venue: Journal of Clinical Medicine

DOI: https://doi.org/10.3390/jcm8040433

Paper Selective Senolysis of 5FU-Induced CRC Senescent Cells by Piceatannol Through Mitochondrial Depolarization and AIF-Dependent Apoptosis.

Ambrosino, Alessia; Patrone, Deanira; Moriello, Claudia et al. · 2025 · International journal of molecular sciences · DOI

Full title: Selective Senolysis of 5FU-Induced CRC Senescent Cells by Piceatannol Through Mitochondrial Depolarization and AIF-Dependent Apoptosis.

Authors: Ambrosino, Alessia; Patrone, Deanira; Moriello, Claudia; Al-Sammarraie, Sura Hilal Ahmed; Lettiero, Ida; Finicelli, Mauro; Siniscalco, Dario; Alessio, Nicola

Year: 2025

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms26189134

Paper Cellular Senescence in Cardiovascular Diseases: From Pathogenesis to Therapeutic Challenges.

Li, Dan; Li, Yongnan; Ding, Hong et al. · 2023 · Journal of cardiovascular development and disease · DOI

Full title: Cellular Senescence in Cardiovascular Diseases: From Pathogenesis to Therapeutic Challenges.

Authors: Li, Dan; Li, Yongnan; Ding, Hong; Wang, Yuqin; Xie, Yafei; Zhang, Xiaowei

Year: 2023

Venue: Journal of cardiovascular development and disease

DOI: https://doi.org/10.3390/jcdd10100439

Paper Endothelial Senescence and the Chronic Vascular Diseases: Challenges and Therapeutic Opportunities in Atherosclerosis

Ramı́rez, Rafael; Ceprián, Noemí; Figuer, Andrea et al. · 2022 · Journal of Personalized Medicine · DOI

Full title: Endothelial Senescence and the Chronic Vascular Diseases: Challenges and Therapeutic Opportunities in Atherosclerosis

Authors: Ramı́rez, Rafael; Ceprián, Noemí; Figuer, Andrea; Valera, Gemma; Bodega, Guillermo; Alique, Matilde; Carracedo, Julia

Year: 2022

Venue: Journal of Personalized Medicine

DOI: https://doi.org/10.3390/jpm12020215

Paper Reduction in Lens Epithelial Cell Senescence Burden through Dasatinib Plus Quercetin or Rapamycin Alleviates D-Galactose-Induced Cataract Progression

Yinhao Wang; Yu-Ling Tseng; K. Chen et al. · 2022 · Journal of Functional Biomaterials · DOI

Full title: Reduction in Lens Epithelial Cell Senescence Burden through Dasatinib Plus Quercetin or Rapamycin Alleviates D-Galactose-Induced Cataract Progression

Authors: Yinhao Wang; Yu-Ling Tseng; K. Chen; Xing-jin Wang; Z. Mao; Xuemin Li

Year: 2022

Venue: Journal of Functional Biomaterials

DOI: https://doi.org/10.3390/jfb14010006

Paper Investigating the Effects of Chelidonic Acid on Oxidative Stress-Induced Premature Cellular Senescence in Human Skin Fibroblast Cells

Turkoglu, Burcu; Mansuroğlu, Banu · 2024 · Life · DOI

Full title: Investigating the Effects of Chelidonic Acid on Oxidative Stress-Induced Premature Cellular Senescence in Human Skin Fibroblast Cells

Authors: Turkoglu, Burcu; Mansuroğlu, Banu

Year: 2024

Venue: Life

DOI: https://doi.org/10.3390/life14091070

Paper Temozolomide, Procarbazine and Nitrosoureas in the Therapy of Malignant Gliomas: Update of Mechanisms, Drug Resistance and Therapeutic Implications.

Kaina, Bernd · 2023 · Journal of clinical medicine · DOI

Full title: Temozolomide, Procarbazine and Nitrosoureas in the Therapy of Malignant Gliomas: Update of Mechanisms, Drug Resistance and Therapeutic Implications.

Authors: Kaina, Bernd

Year: 2023

Venue: Journal of clinical medicine

DOI: https://doi.org/10.3390/jcm12237442

Paper Fisetin as a Senotherapeutic Agent: Biopharmaceutical Properties and Crosstalk between Cell Senescence and Neuroprotection.

Elsallabi, Osama; Patruno, Antonia; Pesce, Mirko et al. · 2022 · Molecules (Basel, Switzerland) · DOI

Full title: Fisetin as a Senotherapeutic Agent: Biopharmaceutical Properties and Crosstalk between Cell Senescence and Neuroprotection.

Authors: Elsallabi, Osama; Patruno, Antonia; Pesce, Mirko; Cataldi, Amelia; Carradori, Simone; Gallorini, Marialucia

Year: 2022

Venue: Molecules (Basel, Switzerland)

DOI: https://doi.org/10.3390/molecules27030738

Paper Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer’s Disease: A Systematic Review

Gruendler, Reinhard; Hippe, Berit; Jengić, Vesna Šendula et al. · 2020 · Molecules · DOI

Full title: Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer’s Disease: A Systematic Review

Authors: Gruendler, Reinhard; Hippe, Berit; Jengić, Vesna Šendula; Peterlin, Borut; Haslberger, Alexander G.

Year: 2020

Venue: Molecules

DOI: https://doi.org/10.3390/molecules25246018

Paper Anti-Leukemic Properties of Aplysinopsin Derivative EE-84 Alone and Combined to BH3 Mimetic A-1210477.

Song, Sungmi; Kim, Sua; El-Sawy, Eslam R et al. · 2021 · Marine drugs · DOI

Full title: Anti-Leukemic Properties of Aplysinopsin Derivative EE-84 Alone and Combined to BH3 Mimetic A-1210477.

Authors: Song, Sungmi; Kim, Sua; El-Sawy, Eslam R; Cerella, Claudia; Orlikova-Boyer, Barbora; Kirsch, Gilbert; Christov, Christo; Dicato, Mario; Diederich, Marc

Year: 2021

Venue: Marine drugs

DOI: https://doi.org/10.3390/md19060285

Paper Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and Aging

E. Mavrogonatou; Dimitrios Kletsas · 2024 · Metabolites · DOI

Full title: Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and Aging

Authors: E. Mavrogonatou; Dimitrios Kletsas

Year: 2024

Venue: Metabolites

DOI: https://doi.org/10.3390/metabo14030146

Paper Impact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human Senescence

Amato, Mariacristina; Polizzi, Alessandro; Viglianisi, Gaia et al. · 2025 · Metabolites · DOI

Full title: Impact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human Senescence

Authors: Amato, Mariacristina; Polizzi, Alessandro; Viglianisi, Gaia; Leonforte, Francesco; Mascitti, Marco; Isola, Gaetano

Year: 2025

Venue: Metabolites

DOI: https://doi.org/10.3390/metabo15010035

Paper Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review

Uyanga, Victoria Anthony; Amevor, Felix Kwame; Liu, Min et al. · 2021 · Nutrients · DOI

Full title: Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review

Authors: Uyanga, Victoria Anthony; Amevor, Felix Kwame; Liu, Min; Cui, Zhifu; Zhao, Xiaoling; Lin, Hai

Year: 2021

Venue: Nutrients

DOI: https://doi.org/10.3390/nu13113782

Paper Quercetin Is An Active Agent in Berries against Neurodegenerative Diseases Progression through Modulation of Nrf2/HO1

Bayazid, Al Borhan; Lim, Beong Ou · 2022 · Nutrients · DOI

Full title: Quercetin Is An Active Agent in Berries against Neurodegenerative Diseases Progression through Modulation of Nrf2/HO1

Authors: Bayazid, Al Borhan; Lim, Beong Ou

Year: 2022

Venue: Nutrients

DOI: https://doi.org/10.3390/nu14235132

Paper Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature

Crocetto, Felice; Zazzo, Erika Di; Buonerba, Carlo et al. · 2021 · Nutrients · DOI

Full title: Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature

Authors: Crocetto, Felice; Zazzo, Erika Di; Buonerba, Carlo; Aveta, Achille; Pandolfo, Savio Domenico; Barone, Biagio; Trama, Francesco; Caputo, Vincenzo; Scafuri, Luca; Ferro, Matteo; Cosimato, Vincenzo; Fusco, Ferdinando; Imbimbo, Ciro; Lorenzo, Giuseppe Di

Year: 2021

Venue: Nutrients

DOI: https://doi.org/10.3390/nu13113750

Paper Flavonol Technology: From the Compounds' Chemistry to Clinical Research.

Przybylski, Tomasz; Czerniel, Joanna; Dobrosielski, Jakub et al. · 2025 · Molecules (Basel, Switzerland) · DOI

Full title: Flavonol Technology: From the Compounds' Chemistry to Clinical Research.

Authors: Przybylski, Tomasz; Czerniel, Joanna; Dobrosielski, Jakub; Stawny, Maciej

Year: 2025

Venue: Molecules (Basel, Switzerland)

DOI: https://doi.org/10.3390/molecules30153113

Paper Senotherapeutics for Brain Aging Management

T. Saliev; Prim B. Singh · 2025 · Neurology International · DOI

Full title: Senotherapeutics for Brain Aging Management

Authors: T. Saliev; Prim B. Singh

Year: 2025

Venue: Neurology International

DOI: https://doi.org/10.3390/neurolint17120204

Paper Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence

Balasubramanian, Priya; Kiss, Tamás; Gulej, Rafał et al. · 2024 · Nutrients · DOI

Full title: Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence

Authors: Balasubramanian, Priya; Kiss, Tamás; Gulej, Rafał; Toth, Adam Nyul; Tarantini, Stefano; Yabluchanskiy, Andriy; Ungvári, Zoltán; Csiszár, Anna

Year: 2024

Venue: Nutrients

DOI: https://doi.org/10.3390/nu16070952

Paper Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan.

Sharma, Arastu; Chabloz, Sophie; Lapides, Rebecca A et al. · 2023 · Nutrients · DOI

Full title: Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan.

Authors: Sharma, Arastu; Chabloz, Sophie; Lapides, Rebecca A; Roider, Elisabeth; Ewald, Collin Y

Year: 2023

Venue: Nutrients

DOI: https://doi.org/10.3390/nu15020445

Paper Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury

Zhang, Xiaohui; Tang, Yufeng; Lu, Guangping et al. · 2023 · Nutrients · DOI

Full title: Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury

Authors: Zhang, Xiaohui; Tang, Yufeng; Lu, Guangping; Gu, Junlian

Year: 2023

Venue: Nutrients

DOI: https://doi.org/10.3390/nu15092231

Paper Cellular Senescence and Iron Dyshomeostasis in Alzheimer’s Disease

Masaldan, Shashank; Belaidi, Abdel Ali; Ayton, Scott et al. · 2019 · Pharmaceuticals · DOI

Full title: Cellular Senescence and Iron Dyshomeostasis in Alzheimer’s Disease

Authors: Masaldan, Shashank; Belaidi, Abdel Ali; Ayton, Scott; Bush, Ashley I.

Year: 2019

Venue: Pharmaceuticals

DOI: https://doi.org/10.3390/ph12020093

Paper Phenotypic Screening in C. elegans as a Tool for the Discovery of New Geroprotective Drugs

Bulterijs, Sven; Braeckman, Bart P. · 2020 · Pharmaceuticals · DOI

Full title: Phenotypic Screening in C. elegans as a Tool for the Discovery of New Geroprotective Drugs

Authors: Bulterijs, Sven; Braeckman, Bart P.

Year: 2020

Venue: Pharmaceuticals

DOI: https://doi.org/10.3390/ph13080164

Paper Quercetin as a Therapeutic Product: Evaluation of Its Pharmacological Action and Clinical Applications—A Review

Mirza, Mohd. Aamir; Mahmood, Syed; Hilles, Ayah Rebhi et al. · 2023 · Pharmaceuticals · DOI

Full title: Quercetin as a Therapeutic Product: Evaluation of Its Pharmacological Action and Clinical Applications—A Review

Authors: Mirza, Mohd. Aamir; Mahmood, Syed; Hilles, Ayah Rebhi; Ali, Abuzer; Khan, Mohammed Zaafar; Zaidi, Syed Amir Azam; Iqbal, Zeenat; Ge, Yi

Year: 2023

Venue: Pharmaceuticals

DOI: https://doi.org/10.3390/ph16111631

Paper Quercetin Intake and Absolute Telomere Length in Patients with Type 2 Diabetes Mellitus: Novel Findings from a Randomized Controlled Before-and-After Study

Mantadaki, Aikaterini E.; Baliou, Stella; Linardakis, Manolis et al. · 2024 · Pharmaceuticals · DOI

Full title: Quercetin Intake and Absolute Telomere Length in Patients with Type 2 Diabetes Mellitus: Novel Findings from a Randomized Controlled Before-and-After Study

Authors: Mantadaki, Aikaterini E.; Baliou, Stella; Linardakis, Manolis; Vakonaki, Elena; Tzatzarakis, Manolis; Tsatsakis, Aristides; Symvoulakis, Emmanouil K.

Year: 2024

Venue: Pharmaceuticals

DOI: https://doi.org/10.3390/ph17091136

Paper Targeting senescent cells enhances adipogenesis and metabolic function in old age

Xu, Ming; Palmer, Allyson K.; Ding, Husheng et al. · 2015 · eLife · DOI

Full title: Targeting senescent cells enhances adipogenesis and metabolic function in old age

Authors: Xu, Ming; Palmer, Allyson K.; Ding, Husheng; Weivoda, Megan; Pirtskhalava, Tamar; White, Thomas A.; Sepe, Anna; Johnson, Kurt O.; Stout, Michael B.; Giorgadze, Nino; Jensen, Michael D.; LeBrasseur, Nathan K.; Tchkonia, Tamar; Kirkland, James L.

Year: 2015

Venue: eLife

DOI: https://doi.org/10.7554/elife.12997

Paper Senescence of endplate osteoclasts induces sensory innervation and spinal pain

Pan, Dayu; Benkato, Kheiria Gamal; Han, Xuequan et al. · 2023 · DOI

Full title: Senescence of endplate osteoclasts induces sensory innervation and spinal pain

Authors: Pan, Dayu; Benkato, Kheiria Gamal; Han, Xuequan; Zheng, Jinjian; Kumar, Vijay; Wan, Mei; Zheng, Junying; Cao, Xu

Year: 2023

DOI: https://doi.org/10.1136/heartjnl-2018-bcs.105

Paper Classic challenges and emerging approaches to medication therapy in older adults.

Alagiakrishnan, Kannayiram; Mah, Darren; Padwal, Raj · 2018 · Discovery medicine

Full title: Classic challenges and emerging approaches to medication therapy in older adults.

Authors: Alagiakrishnan, Kannayiram; Mah, Darren; Padwal, Raj

Year: 2018

Venue: Discovery medicine

Paper Editor's evaluation: Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart

Huang, Christopher · 2023 · DOI

Full title: Editor's evaluation: Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart

Authors: Huang, Christopher

Year: 2023

DOI: https://doi.org/10.7554/elife.84088.sa0

Paper Senotherapeutic drugs for human intervertebral disc degeneration and low back pain

Hosni Cherif; D. Bisson; M. Mannarino et al. · 2020 · eLife · DOI

Full title: Senotherapeutic drugs for human intervertebral disc degeneration and low back pain

Authors: Hosni Cherif; D. Bisson; M. Mannarino; O. Rabau; J. Ouellet; L. Haglund

Year: 2020

Venue: eLife

DOI: https://doi.org/10.7554/elife.54693

Paper A Review of Cellular Senescence and Senolytic Drugs Use in Idiopathic Pulmonary Fibrosis

K. Blirando · 2020

Full title: A Review of Cellular Senescence and Senolytic Drugs Use in Idiopathic Pulmonary Fibrosis

Authors: K. Blirando

Year: 2020

Paper CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis.

Fu, Liangliang; Yin, Chenghu; Zhao, Qin et al. · 2025 · eLife · DOI

Full title: CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis.

Authors: Fu, Liangliang; Yin, Chenghu; Zhao, Qin; Guo, Shuling; Shao, Wenjun; Xia, Ting; Sun, Quan; Chen, Liangwen; Li, Jinghan; Wang, Min; Xia, Haibin

Year: 2025

Venue: eLife

DOI: https://doi.org/10.7554/eLife.96908

Paper CLINICAL MANAGEMENT OF THE OLDER ADULT The Clinical Potential of Senolytic Drugs

J. Kirkland; T. Tchkonia; Yi Zhu et al. · 2017

Full title: CLINICAL MANAGEMENT OF THE OLDER ADULT The Clinical Potential of Senolytic Drugs

Authors: J. Kirkland; T. Tchkonia; Yi Zhu; L. Niedernhofer; P. Robbins

Year: 2017

Paper 1 Senescent, dysfunctional human cardiac progenitor cells (CPCs) accumulate in the aged heart and elimination of senescent cells enhances CPC activation and cardiomyocyte proliferation in aged mice

Fiona C Lewis-McDougall; P. Ruchaya; Eva Domenjo-Vila et al. · 2018

Full title: 1 Senescent, dysfunctional human cardiac progenitor cells (CPCs) accumulate in the aged heart and elimination of senescent cells enhances CPC activation and cardiomyocyte proliferation in aged mice

Year: 2018

Paper Potential Disease-Modifying Treatment Strategies Targeting Senescence in the Setting of Knee Osteoarthritis

W. S. Hambright; Austin Yeargan; Justin E. Hellwinkel et al. · 2021

Full title: Potential Disease-Modifying Treatment Strategies Targeting Senescence in the Setting of Knee Osteoarthritis

Authors: W. S. Hambright; Austin Yeargan; Justin E. Hellwinkel; Kaitlyn E Whitney; B. E. Montgomery; M. Philippon; Thos A. Evans; B. Péault; J. Buckwalter; J. Huard

Year: 2021

Paper Assessing the Effect of PROTAC 753b Senolytic on Intervertebral Disc Aging

Peter G Alexander; K. L. Clark; Dong Wang et al.

Full title: Assessing the Effect of PROTAC 753b Senolytic on Intervertebral Disc Aging

Authors: Peter G Alexander; K. L. Clark; Dong Wang; Qing D Dong; Joon Y. Lee; Gwendolyn A. Sowa; Daohong Zhou; N. Vo

Paper Age-Related Alterations in Immune Function and Inflammation: Focus on Ischemic Stroke

Chen, Qiuxin; Wu, Minmin; Tang, Qiang et al. · 2023 · Aging and Disease · DOI

Full title: Age-Related Alterations in Immune Function and Inflammation: Focus on Ischemic Stroke

Authors: Chen, Qiuxin; Wu, Minmin; Tang, Qiang; Yan, Peiyu; Zhu, Luwen

Year: 2023

Venue: Aging and Disease

DOI: https://doi.org/10.14336/ad.2023.0721-1

Paper Underlying Mechanisms and Treatment of Cellular Senescence-Induced Biological Barrier Interruption and Related Diseases

Sun, Ruize; Feng, Juan; Wang, Jue · 2023 · Aging and Disease · DOI

Full title: Underlying Mechanisms and Treatment of Cellular Senescence-Induced Biological Barrier Interruption and Related Diseases

Authors: Sun, Ruize; Feng, Juan; Wang, Jue

Year: 2023

Venue: Aging and Disease

DOI: https://doi.org/10.14336/ad.2023.0621

Paper Aging, Cellular Senescence, and Glaucoma

Zhang, Yumeng; Huang, Shouyue; Xie, Bing et al. · 2024 · Aging and Disease · DOI

Full title: Aging, Cellular Senescence, and Glaucoma

Authors: Zhang, Yumeng; Huang, Shouyue; Xie, Bing; Zhong, Yisheng

Year: 2024

Venue: Aging and Disease

DOI: https://doi.org/10.14336/ad.2023.0630-1

Paper The Bcl-2/Bcl-xL Inhibitor ABT-263 Attenuates Retinal Degeneration by Selectively Inducing Apoptosis in Senescent Retinal Pigment Epithelial Cells.

Ryu, Wonseon; Park, Chul-Woo; Kim, Junghoon et al. · 2023 · Molecules and cells · DOI

Full title: The Bcl-2/Bcl-xL Inhibitor ABT-263 Attenuates Retinal Degeneration by Selectively Inducing Apoptosis in Senescent Retinal Pigment Epithelial Cells.

Authors: Ryu, Wonseon; Park, Chul-Woo; Kim, Junghoon; Lee, Hyungwoo; Chung, Hyewon

Year: 2023

Venue: Molecules and cells

DOI: https://doi.org/10.14348/molcells.2023.2188

Paper Senolytics and Senostatics: A Two-Pronged Approach to Target Cellular Senescence for Delaying Aging and Age-Related Diseases.

Kang, Chanhee · 2019 · Molecules and cells · DOI

Full title: Senolytics and Senostatics: A Two-Pronged Approach to Target Cellular Senescence for Delaying Aging and Age-Related Diseases.

Authors: Kang, Chanhee

Year: 2019

Venue: Molecules and cells

DOI: https://doi.org/10.14348/molcells.2019.0298

Paper The Complex Bidirectional Relationship Between Aging and Atherosclerosis: Mechanistic Insights and Translational Opportunities.

You, Binquan; Yi, Dong; Wang, Bingyin et al. · 2025 · Aging and disease · DOI

Full title: The Complex Bidirectional Relationship Between Aging and Atherosclerosis: Mechanistic Insights and Translational Opportunities.

Authors: You, Binquan; Yi, Dong; Wang, Bingyin; Yan, Hua

Year: 2025

Venue: Aging and disease

DOI: https://doi.org/10.14336/AD.2025.10620

Paper Senescent T Cells in Age-Related Diseases

Yu, Pei-Jie; Zhou, Mei; Liu, Yan et al. · 2024 · Aging and Disease · DOI

Full title: Senescent T Cells in Age-Related Diseases

Authors: Yu, Pei-Jie; Zhou, Mei; Liu, Yan; Du, Jie

Year: 2024

Venue: Aging and Disease

DOI: https://doi.org/10.14336/ad.2024.0219

Paper Targeting Cell Senescence to Improve Cardiac Regeneration

Ellison, Georgina M. · 2023 · Texas Heart Institute Journal · DOI

Full title: Targeting Cell Senescence to Improve Cardiac Regeneration

Authors: Ellison, Georgina M.

Year: 2023

Venue: Texas Heart Institute Journal

DOI: https://doi.org/10.14503/thij-23-8262

Paper Prospects of Pharmacological Interventions to Organismal Aging

Hillson, Olivia; Gonzalez, Suam; Rallis, Charalampos · 2018 · BioMolecular Concepts · DOI

Full title: Prospects of Pharmacological Interventions to Organismal Aging

Authors: Hillson, Olivia; Gonzalez, Suam; Rallis, Charalampos

Year: 2018

Venue: BioMolecular Concepts

DOI: https://doi.org/10.1515/bmc-2018-0018

Paper RISING STARS: Targeting premature cellular senescence using senomorphic or senolytic agents to impact diabetes.

van de Vyver, Mari; Govender, Saiuree; Petersen-Ross, Kelly et al. · 2025 · Journal of molecular endocrinology · DOI

Full title: RISING STARS: Targeting premature cellular senescence using senomorphic or senolytic agents to impact diabetes.

Authors: van de Vyver, Mari; Govender, Saiuree; Petersen-Ross, Kelly; Howard, Kayla

Year: 2025

Venue: Journal of molecular endocrinology

DOI: https://doi.org/10.1530/JME-25-0052

Paper The aging endothelium

Ting, Ka Ka; Coleman, Paul; Zhao, Yang et al. · 2021 · Vascular Biology · DOI

Full title: The aging endothelium

Authors: Ting, Ka Ka; Coleman, Paul; Zhao, Yang; Vadas, Mathew A.; Gamble, Jennifer R.

Year: 2021

Venue: Vascular Biology

DOI: https://doi.org/10.1530/vb-20-0013

Paper Advances and challenges in geroscience research: An update

Yabluchanskiy, Andriy; Ungvári, Zoltán; Csiszár, Anna et al. · 2018 · Physiology International · DOI

Full title: Advances and challenges in geroscience research: An update

Authors: Yabluchanskiy, Andriy; Ungvári, Zoltán; Csiszár, Anna; Tarantini, Stefano

Year: 2018

Venue: Physiology International

DOI: https://doi.org/10.1556/2060.105.2018.4.32

Paper The Aging Kidney and Acute Kidney Injury.

Karl A. Nath; R. D. Singh; A. J. Croatt et al. · 2025 · Journal of the American Society of Nephrology · DOI

Full title: The Aging Kidney and Acute Kidney Injury.

Authors: Karl A. Nath; R. D. Singh; A. J. Croatt; Luis A. Juncos

Year: 2025

Venue: Journal of the American Society of Nephrology

DOI: https://doi.org/10.1681/asn.0000001002

Paper JAK2/STAT3 regulates estrogen-related senescence of bone marrow stem cells

Wu, Wenjing; Fu, Jiayao; Gu, Yijing et al. · 2020 · Journal of Endocrinology · DOI

Full title: JAK2/STAT3 regulates estrogen-related senescence of bone marrow stem cells

Authors: Wu, Wenjing; Fu, Jiayao; Gu, Yijing; Yu, Wei; Ma, Pengfei; Wu, Junhua

Year: 2020

Venue: Journal of Endocrinology

DOI: https://doi.org/10.1530/joe-19-0518

Paper Assessing the Complexities of Utilizing BH3 Mimetics for a Senolytic Strategy in Combination with Ionizing Radiation.

Alshehri, Muruj; Saleh, Tareq; Anscher, Mitchell S et al. · 2026 · Radiation research · DOI

Full title: Assessing the Complexities of Utilizing BH3 Mimetics for a Senolytic Strategy in Combination with Ionizing Radiation.

Authors: Alshehri, Muruj; Saleh, Tareq; Anscher, Mitchell S; Boyd, Rowan; Harada, Hisashi; Gewirtz, David A

Year: 2026

Venue: Radiation research

DOI: https://doi.org/10.1667/RADE-25-00156.1

Paper Can senolysis be used to overcome tumor immune evasion?

Wally Veklych; T. Ichim; Robert Reznik et al. · 2024 · Journal of Stem Cell Research & Therapeutics · DOI

Full title: Can senolysis be used to overcome tumor immune evasion?

Authors: Wally Veklych; T. Ichim; Robert Reznik; Vladyslav Bykoriz; Yuri Kaplun; Boris Minev; Anil Bajnath; Emma Lin; Valerii Cheshuk; Boris N. Reznik

Year: 2024

Venue: Journal of Stem Cell Research & Therapeutics

DOI: https://doi.org/10.15406/jsrt.2024.09.00169

Paper The Roles of Autophagy and Senescence in the Tumor Cell Response to Radiation.

Patel, Nipa H; Sohal, Sahib S; Manjili, Masoud H et al. · 2020 · Radiation research · DOI

Full title: The Roles of Autophagy and Senescence in the Tumor Cell Response to Radiation.

Authors: Patel, Nipa H; Sohal, Sahib S; Manjili, Masoud H; Harrell, J Chuck; Gewirtz, David A

Year: 2020

Venue: Radiation research

DOI: https://doi.org/10.1667/RADE-20-00009

Paper Kidney Disease as a Driver of Immunosenescence: Mechanisms and Potential Interventions.

Song, Zhuolun; Tsou, Sarah; Martin, Friederike et al. · 2026 · Journal of the American Society of Nephrology : JASN · DOI

Full title: Kidney Disease as a Driver of Immunosenescence: Mechanisms and Potential Interventions.

Authors: Song, Zhuolun; Tsou, Sarah; Martin, Friederike; Kayumov, Mukhammad; Xiao, Yao; Zhou, Hao; Abdi, Reza; Tullius, Stefan G

Year: 2026

Venue: Journal of the American Society of Nephrology : JASN

DOI: https://doi.org/10.1681/ASN.0000000896

Paper From causes of aging to death from COVID-19

Blagosklonny, Mikhail V. · 2020 · Aging · DOI

Full title: From causes of aging to death from COVID-19

Authors: Blagosklonny, Mikhail V.

Year: 2020

Venue: Aging

DOI: https://doi.org/10.18632/aging.103493

Paper Senolytic drugs relieve pain by reducing peripheral nociceptive signaling without modifying joint tissue damage in spontaneous osteoarthritis

Gil, Tae‐Hwan; Zheng, Haiyan; Lee, Hyo Gyeong et al. · 2022 · Aging · DOI

Full title: Senolytic drugs relieve pain by reducing peripheral nociceptive signaling without modifying joint tissue damage in spontaneous osteoarthritis

Authors: Gil, Tae‐Hwan; Zheng, Haiyan; Lee, Hyo Gyeong; Shin, Jiwon; Hwang, Sun Wook; Jang, Ki-Mo; Jeon, Ok Hee

Year: 2022

Venue: Aging

DOI: https://doi.org/10.18632/aging.204204

Paper Targeting anticancer drug-induced senescence in glioblastoma therapy

M. Tomicic; M. Christmann · 2018 · OncoTarget · DOI

Full title: Targeting anticancer drug-induced senescence in glioblastoma therapy

Authors: M. Tomicic; M. Christmann

Year: 2018

Venue: OncoTarget

DOI: https://doi.org/10.18632/oncotarget.26502

Paper Senescence and senotherapies in biliary atresia and biliary cirrhosis

Jannone, Giulia; Riani, Eliano Bonaccorsi; Magnée, Catherine de et al. · 2023 · Aging · DOI

Full title: Senescence and senotherapies in biliary atresia and biliary cirrhosis

Authors: Jannone, Giulia; Riani, Eliano Bonaccorsi; Magnée, Catherine de; Tambucci, Roberto; Evraerts, Jonathan; Ravau, Joachim; Baldin, Paméla; Bouzin, Caroline; Loriot, Axelle; Gatto, Laurent; Decottignies, Anabelle; Najimi, Mustapha; Sokal, Étienne

Year: 2023

Venue: Aging

DOI: https://doi.org/10.18632/aging.204700

Paper Pathogenesis of Aging and Age-related Comorbidities in People with HIV: Highlights from the HIV ACTION Workshop

Gabuzda, Dana; Jamieson, Beth D.; Collman, Ronald G. et al. · 2020 · Pathogens and Immunity · DOI

Full title: Pathogenesis of Aging and Age-related Comorbidities in People with HIV: Highlights from the HIV ACTION Workshop

Authors: Gabuzda, Dana; Jamieson, Beth D.; Collman, Ronald G.; Lederman, Michael M.; Burdo, Tricia H.; Deeks, Steven G.; Dittmer, Dirk P.; Fox, Howard S.; Funderburg, Nicholas; Pahwa, Savita; Pandrea, Ivona; Wilson, Cara C.; Hunt, Peter W.

Year: 2020

Venue: Pathogens and Immunity

DOI: https://doi.org/10.20411/pai.v5i1.365

Paper Untitled

Liu, Lei, Yue, Xianlin, Sun, Zewei, Hambright, William S., Feng, Qi, Cui, Yan, Huard, Johnny, Robbins, Paul D., Wang, Zhihui, Mu, Xiaodong, Odel, Cruz-Guzmn, Rodrguez-Cruz, R, M, Cedillo, Escobar, R, Rosenberg, A, Puig, M, Nagaraju, K, Hoffman, E, Villalta, S, Rao, V, Wakefield, L, Woodcock, J, Mu, X, Lin, C, Hambright, W, Tang, Y, Ravuri, S, Lu, A, Matre, P, Gao, Chen, Cui, X, Zhong, Y, Wang, L, Huard, B, J, Mu, X, Tang, Y, Takayama, K, Lu, Chen, Wang, A, Weiss, B, Huard, K, J, Yousefzadeh, M, Flores, R, Zhu, Y, Schmiechen, Z, Brooks, R, Trussoni, C, Cui, Y, Angelini, L, Lee, K, Mcgowan, S, Burrack, A, Wang, D, Dong, Q, Prata, Lgp, Ovsyannikova, I, Tchkonia, T, Kirkland, J, Song, P, An, J, Zou, M, Childs, B, Durik, M, Baker, D, Deursen, J Van, Robbins, P, Jurk, D, Khosla, S, Kirkland, J, Lebrasseur, N, Miller, J, Passos, J, Pignolo, R, Tchkonia, T, Niedernhofer, L, Copp, J, Desprez, P, Krtolica, A, Campisi, J, Victorelli, S, Passos, J, Hickson, L, Prata, Langhi, Bobart, Lgp, Evans, S, Giorgadze, T, Hashmi, N, Herrmann, S, Jensen, S, Jia, M, Jordan, Q, Kellogg, K, Khosla, T, Koerber, S, D, Kirkland, J, Tchkonia, T · 2022 · Aging · DOI

Full title: Untitled

Authors: Liu, Lei, Yue, Xianlin, Sun, Zewei, Hambright, William S., Feng, Qi, Cui, Yan, Huard, Johnny, Robbins, Paul D., Wang, Zhihui, Mu, Xiaodong, Odel, Cruz-Guzmn, Rodrguez-Cruz, R, M, Cedillo, Escobar, R, Rosenberg, A, Puig, M, Nagaraju, K, Hoffman, E, Villalta, S, Rao, V, Wakefield, L, Woodcock, J, Mu, X, Lin, C, Hambright, W, Tang, Y, Ravuri, S, Lu, A, Matre, P, Gao, Chen, Cui, X, Zhong, Y, Wang, L, Huard, B, J, Mu, X, Tang, Y, Takayama, K, Lu, Chen, Wang, A, Weiss, B, Huard, K, J, Yousefzadeh, M, Flores, R, Zhu, Y, Schmiechen, Z, Brooks, R, Trussoni, C, Cui, Y, Angelini, L, Lee, K, Mcgowan, S, Burrack, A, Wang, D, Dong, Q, Prata, Lgp, Ovsyannikova, I, Tchkonia, T, Kirkland, J, Song, P, An, J, Zou, M, Childs, B, Durik, M, Baker, D, Deursen, J Van, Robbins, P, Jurk, D, Khosla, S, Kirkland, J, Lebrasseur, N, Miller, J, Passos, J, Pignolo, R, Tchkonia, T, Niedernhofer, L, Copp, J, Desprez, P, Krtolica, A, Campisi, J, Victorelli, S, Passos, J, Hickson, L, Prata, Langhi, Bobart, Lgp, Evans, S, Giorgadze, T, Hashmi, N, Herrmann, S, Jensen, S, Jia, M, Jordan, Q, Kellogg, K, Khosla, T, Koerber, S, D, Kirkland, J, Tchkonia, T

Year: 2022

Venue: Aging

DOI: https://doi.org/10.18632/aging.v14i19

Paper Untitled

Blagosklonny, Mikhail V., Blagosklonny, M, Blagosklonny, M, Keaney, M, Gems, D, Doonan, R, Mcelwee, J, Matthijssens, F, Walker, G, Houthoofd, K, Back, P, Matscheski, A, Vanfleteren, J, Gems, D, Perez, V, Bokov, A, Remmen, H Van, Mele, J, Ran, Q, Ikeno, Y, Richardson, A, Ristow, M, Schmeisser, S, Ristow, M, Schmeisser, K, Raamsdonk, J Van, Hekimi, S, Blagosklonny, M, Gems, D, Guardia, Y De La, Selman, C, Mclaren, J, Collins, A, Duthie, G, Speakman, J, Selman, C, Mclaren, J, Meyer, C, Duncan, J, Redman, P, Collins, A, Duthie, G, Speakman, J, Bjelakovic, G, Nikolova, D, Gluud, L, Simonetti, R, Gluud, C, Bjelakovic, G, Nikolova, D, Gluud, C, Omenn, G, Goodman, G, Thornquist, M, Balmes, J, Cullen, M, Glass, A, Keogh, J, Meyskens, F, Valanis, B, Williams, J, Barnhart, S, Hammar, S, Goodman, G, Thornquist, M, Balmes, J, Cullen, M, Meyskens, F, Jr, Omenn, G, Valanis, B, Williams, J, Wright, M, Virtamo, J, Hartman, A, Pietinen, P, Edwards, B, Taylor, P, Huttunen, J, Albanes, D, Sayin, V, Ibrahim, M, Larsson, E, Nilsson, J, Lindahl, P, Bergo, M, Piskounova, E, Agathocleous, M, Murphy, M, Hu, Z, Huddlestun, S, Zhao, Z, Leitch, A, Johnson, T, Deberardinis, R, Morrison, S, Blagosklonny, M, Blagosklonny, M, Blagosklonny, M, Burch, J · 2021 · Oncotarget · DOI

Full title: Untitled

Authors: Blagosklonny, Mikhail V., Blagosklonny, M, Blagosklonny, M, Keaney, M, Gems, D, Doonan, R, Mcelwee, J, Matthijssens, F, Walker, G, Houthoofd, K, Back, P, Matscheski, A, Vanfleteren, J, Gems, D, Perez, V, Bokov, A, Remmen, H Van, Mele, J, Ran, Q, Ikeno, Y, Richardson, A, Ristow, M, Schmeisser, S, Ristow, M, Schmeisser, K, Raamsdonk, J Van, Hekimi, S, Blagosklonny, M, Gems, D, Guardia, Y De La, Selman, C, Mclaren, J, Collins, A, Duthie, G, Speakman, J, Selman, C, Mclaren, J, Meyer, C, Duncan, J, Redman, P, Collins, A, Duthie, G, Speakman, J, Bjelakovic, G, Nikolova, D, Gluud, L, Simonetti, R, Gluud, C, Bjelakovic, G, Nikolova, D, Gluud, C, Omenn, G, Goodman, G, Thornquist, M, Balmes, J, Cullen, M, Glass, A, Keogh, J, Meyskens, F, Valanis, B, Williams, J, Barnhart, S, Hammar, S, Goodman, G, Thornquist, M, Balmes, J, Cullen, M, Meyskens, F, Jr, Omenn, G, Valanis, B, Williams, J, Wright, M, Virtamo, J, Hartman, A, Pietinen, P, Edwards, B, Taylor, P, Huttunen, J, Albanes, D, Sayin, V, Ibrahim, M, Larsson, E, Nilsson, J, Lindahl, P, Bergo, M, Piskounova, E, Agathocleous, M, Murphy, M, Hu, Z, Huddlestun, S, Zhao, Z, Leitch, A, Johnson, T, Deberardinis, R, Morrison, S, Blagosklonny, M, Blagosklonny, M, Blagosklonny, M, Burch, J

Year: 2021

Venue: Oncotarget

DOI: https://doi.org/10.18632/oncotarget.v12i3

Paper Senescent Cells: Dual Implications on the Retinal Vascular System.

Habibi-Kavashkohie, Mohammad Reza; Scorza, Tatiana; Oubaha, Malika · 2023 · Cells · DOI

Full title: Senescent Cells: Dual Implications on the Retinal Vascular System.

Authors: Habibi-Kavashkohie, Mohammad Reza; Scorza, Tatiana; Oubaha, Malika

Year: 2023

Venue: Cells

DOI: https://doi.org/10.3390/cells12192341

Paper Potential of Plant-Derived Compounds in Preventing and Reversing Organ Fibrosis and the Underlying Mechanisms

Azeredo, Patrícia dos Santos; Fan, Daping; Murphy, E. Angela et al. · 2024 · Cells · DOI

Full title: Potential of Plant-Derived Compounds in Preventing and Reversing Organ Fibrosis and the Underlying Mechanisms

Authors: Azeredo, Patrícia dos Santos; Fan, Daping; Murphy, E. Angela; Carver, Wayne

Year: 2024

Venue: Cells

DOI: https://doi.org/10.3390/cells13050421

Paper Rejuvenation of Mesenchymal Stem Cells to Ameliorate Skeletal Aging

Cheng, Mingjia; Yuan, Weihao; Moshaverinia, Alireza et al. · 2023 · Cells · DOI

Full title: Rejuvenation of Mesenchymal Stem Cells to Ameliorate Skeletal Aging

Authors: Cheng, Mingjia; Yuan, Weihao; Moshaverinia, Alireza; Yu, Bo

Year: 2023

Venue: Cells

DOI: https://doi.org/10.3390/cells12070998

Paper Impaired Remodeling of White Adipose Tissue in Obesity and Aging: From Defective Adipogenesis to Adipose Organ Dysfunction

Iacobini, Carla; Vitale, Martina; Haxhi, Jonida et al. · 2024 · Cells · DOI

Full title: Impaired Remodeling of White Adipose Tissue in Obesity and Aging: From Defective Adipogenesis to Adipose Organ Dysfunction

Authors: Iacobini, Carla; Vitale, Martina; Haxhi, Jonida; Menini, Stefano; Pugliese, Giuseppe

Year: 2024

Venue: Cells

DOI: https://doi.org/10.3390/cells13090763

Paper Chronological and Biological Aging in Amyotrophic Lateral Sclerosis and the Potential of Senolytic Therapies.

Dashtmian, Anna Roshani; Darvishi, Fereshteh B; Arnold, William David · 2024 · Cells · DOI

Full title: Chronological and Biological Aging in Amyotrophic Lateral Sclerosis and the Potential of Senolytic Therapies.

Authors: Dashtmian, Anna Roshani; Darvishi, Fereshteh B; Arnold, William David

Year: 2024

Venue: Cells

DOI: https://doi.org/10.3390/cells13110928

Paper Flavonoids Regulate Redox-Responsive Transcription Factors in Glioblastoma and Microglia

Joma, Natali; Zhang, Issan; Righetto, Germanna Lima et al. · 2023 · Cells · DOI

Full title: Flavonoids Regulate Redox-Responsive Transcription Factors in Glioblastoma and Microglia

Authors: Joma, Natali; Zhang, Issan; Righetto, Germanna Lima; McKay, Laura M.; Gran, Evan Rizzel; Kakkar, Ashok; Maysinger, Dušica

Year: 2023

Venue: Cells

DOI: https://doi.org/10.3390/cells12242821

Paper Repurposing Drugs for Senotherapeutic Effect: Potential Senomorphic Effects of Female Synthetic Hormones.

Bramwell, Laura R; Frankum, Ryan; Harries, Lorna W · 2024 · Cells · DOI

Full title: Repurposing Drugs for Senotherapeutic Effect: Potential Senomorphic Effects of Female Synthetic Hormones.

Authors: Bramwell, Laura R; Frankum, Ryan; Harries, Lorna W

Year: 2024

Venue: Cells

DOI: https://doi.org/10.3390/cells13060517

Paper The Role of Senescence in Experimental Periodontitis at the Causal Level: An in Vivo Study.

Chu, Xiaogang; Elashiry, Mahmoud; Carroll, Angelica et al. · 2025 · Cells · DOI

Full title: The Role of Senescence in Experimental Periodontitis at the Causal Level: An in Vivo Study.

Authors: Chu, Xiaogang; Elashiry, Mahmoud; Carroll, Angelica; Cornelius Timothius, Celine Joyce; Cutler, Christopher W; Elsayed, Ranya

Year: 2025

Venue: Cells

DOI: https://doi.org/10.3390/cells14030226

Paper From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications

Saliev, Timur; Singh, Prim B. · 2024 · Cells · DOI

Full title: From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications

Authors: Saliev, Timur; Singh, Prim B.

Year: 2024

Venue: Cells

DOI: https://doi.org/10.3390/cells13242052

Paper Recent Advances in Aging and Immunosenescence: Mechanisms and Therapeutic Strategies.

Wang, Shuaiqi; Huo, Tong; Lu, Mingyang et al. · 2025 · Cells · DOI

Full title: Recent Advances in Aging and Immunosenescence: Mechanisms and Therapeutic Strategies.

Authors: Wang, Shuaiqi; Huo, Tong; Lu, Mingyang; Zhao, Yueqi; Zhang, Jianmin; He, Wei; Chen, Hui

Year: 2025

Venue: Cells

DOI: https://doi.org/10.3390/cells14070499

Paper Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases

P. Song; Junqing An; M. Zou · 2020 · Cells · DOI

Full title: Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases

Authors: P. Song; Junqing An; M. Zou

Year: 2020

Venue: Cells

DOI: https://doi.org/10.3390/cells9030671

Paper Molecular Regulation of SASP in Cellular Senescence: Therapeutic Implications and Translational Challenges.

Klepacki, Hubert; Kowalczuk, Krystyna; Łepkowska, Natalia et al. · 2025 · Cells · DOI

Full title: Molecular Regulation of SASP in Cellular Senescence: Therapeutic Implications and Translational Challenges.

Authors: Klepacki, Hubert; Kowalczuk, Krystyna; Łepkowska, Natalia; Hermanowicz, Justyna Magdalena

Year: 2025

Venue: Cells

DOI: https://doi.org/10.3390/cells14130942

Paper From Senescent Cells to Systemic Inflammation: The Role of Inflammaging in Age-Related Diseases and Kidney Dysfunction.

Luca, Federica De; Camporeale, Valentina; Leccese, Giorgia et al. · 2025 · Cells · DOI

Full title: From Senescent Cells to Systemic Inflammation: The Role of Inflammaging in Age-Related Diseases and Kidney Dysfunction.

Authors: Luca, Federica De; Camporeale, Valentina; Leccese, Giorgia; Cuttano, Roberto; Troise, Dario; Infante, Barbara; Stallone, Giovanni; Netti, Giuseppe Stefano; Ranieri, Elena

Year: 2025

Venue: Cells

DOI: https://doi.org/10.3390/cells14221831

Paper Cellular Models of Aging and Senescence.

Kim, Byunggik; Lee, Dong I; Basisty, Nathan et al. · 2025 · Cells · DOI

Full title: Cellular Models of Aging and Senescence.

Authors: Kim, Byunggik; Lee, Dong I; Basisty, Nathan; Dai, Dao-Fu

Year: 2025

Venue: Cells

DOI: https://doi.org/10.3390/cells14161278

Paper Considering Cause and Effect of Immune Cell Aging on Cardiac Repair after Myocardial Infarction

Tobin, Stephanie W.; Alibhai, Faisal J.; Weisel, Richard D. et al. · 2020 · Cells · DOI

Full title: Considering Cause and Effect of Immune Cell Aging on Cardiac Repair after Myocardial Infarction

Authors: Tobin, Stephanie W.; Alibhai, Faisal J.; Weisel, Richard D.; Li, Ren‐Ke

Year: 2020

Venue: Cells

DOI: https://doi.org/10.3390/cells9081894

Paper Tert-Butyl Hydroperoxide in Human Adult Mesenchymal Stem Cells Isolated from Dermis: A Stress-Induced Premature Senescence Model.

Pampanella, Luca; Petrocelli, Giovannamaria; Abruzzo, Provvidenza Maria et al. · 2025 · Cells · DOI

Full title: Tert-Butyl Hydroperoxide in Human Adult Mesenchymal Stem Cells Isolated from Dermis: A Stress-Induced Premature Senescence Model.

Authors: Pampanella, Luca; Petrocelli, Giovannamaria; Abruzzo, Provvidenza Maria; Tassinari, Riccardo; Bassoli, Beatrice; Sgarzani, Rossella; Maioli, Margherita; Ventura, Carlo; Canaider, Silvia; Facchin, Federica

Year: 2025

Venue: Cells

DOI: https://doi.org/10.3390/cells14191563

Paper Multi-Omics Perspectives on Testicular Aging: Unraveling Germline Dysregulation, Niche Dysfunction, and Epigenetic Remodeling

Kaltsas, Aris · 2025 · Cells · DOI

Full title: Multi-Omics Perspectives on Testicular Aging: Unraveling Germline Dysregulation, Niche Dysfunction, and Epigenetic Remodeling

Authors: Kaltsas, Aris

Year: 2025

Venue: Cells

DOI: https://doi.org/10.3390/cells14120899

Paper Nano-Based Theranostic Tools for the Detection and Elimination of Senescent Cells.

Adamczyk-Grochala, Jagoda; Lewinska, Anna · 2020 · Cells · DOI

Full title: Nano-Based Theranostic Tools for the Detection and Elimination of Senescent Cells.

Authors: Adamczyk-Grochala, Jagoda; Lewinska, Anna

Year: 2020

Venue: Cells

DOI: https://doi.org/10.3390/cells9122659

Paper Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy

Triana-Martínez, Francisco; Loza, Marı́a Isabel; Domínguez, Eduardo · 2020 · Cells · DOI

Full title: Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy

Authors: Triana-Martínez, Francisco; Loza, Marı́a Isabel; Domínguez, Eduardo

Year: 2020

Venue: Cells

DOI: https://doi.org/10.3390/cells9020346

Paper Cellular Senescence in Renal and Urinary Tract Disorders

Santin, Yohan; Lluel, Philippe; Rischmann, P. et al. · 2020 · Cells · DOI

Full title: Cellular Senescence in Renal and Urinary Tract Disorders

Authors: Santin, Yohan; Lluel, Philippe; Rischmann, P.; Gamé, X.; Mialet‐Perez, Jeanne; Parini, Angelo

Year: 2020

Venue: Cells

DOI: https://doi.org/10.3390/cells9112420

Paper Insights from In Vivo Studies of Cellular Senescence

Prieto, Luis I.; Graves, Sara I.; Baker, Darren J. · 2020 · Cells · DOI

Full title: Insights from In Vivo Studies of Cellular Senescence

Authors: Prieto, Luis I.; Graves, Sara I.; Baker, Darren J.

Year: 2020

Venue: Cells

DOI: https://doi.org/10.3390/cells9040954

Paper mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases.

Walters, Hannah E; Cox, Lynne S · 2018 · International journal of molecular sciences · DOI

Full title: mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases.

Authors: Walters, Hannah E; Cox, Lynne S

Year: 2018

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms19082325

Paper Senescence Modulation: An Applied Science Review of Strategies in Anti-Aging, Regenerative Aesthetics, and Oncology Therapy.

Kusmanto, Steven Januar · 2025 · Current issues in molecular biology · DOI

Full title: Senescence Modulation: An Applied Science Review of Strategies in Anti-Aging, Regenerative Aesthetics, and Oncology Therapy.

Authors: Kusmanto, Steven Januar

Year: 2025

Venue: Current issues in molecular biology

DOI: https://doi.org/10.3390/cimb47120989

Paper From Lasers to Longevity: Exploring Energy-Based Devices as Senotherapeutic Tools in Dermatology

Oana Mihaela Condurache Hrițcu; V. Costan; Ș. Toader et al. · 2025 · Cosmetics · DOI

Full title: From Lasers to Longevity: Exploring Energy-Based Devices as Senotherapeutic Tools in Dermatology

Authors: Oana Mihaela Condurache Hrițcu; V. Costan; Ș. Toader; D. Brănișteanu; M. Toader

Year: 2025

Venue: Cosmetics

DOI: https://doi.org/10.3390/cosmetics12050201

Paper Senolytic Interventions for Type 2 Diabetes: Current Evidence and Future Directions

Selene Sodini; Milton F Suarez-Ortegón · 2025 · Diabetology · DOI

Full title: Senolytic Interventions for Type 2 Diabetes: Current Evidence and Future Directions

Authors: Selene Sodini; Milton F Suarez-Ortegón

Year: 2025

Venue: Diabetology

DOI: https://doi.org/10.3390/diabetology6060048

Paper Targeting Senescence in Oncology: An Emerging Therapeutic Avenue for Cancer

Meguro, Satoru; Makabe, Syunta; Yaginuma, Kei et al. · 2025 · Current Oncology · DOI

Full title: Targeting Senescence in Oncology: An Emerging Therapeutic Avenue for Cancer

Authors: Meguro, Satoru; Makabe, Syunta; Yaginuma, Kei; Onagi, Akifumi; Tanji, Ryo; Matsuoka, Kanako; Hoshi, Seiji; Koguchi, Tomoyuki; Kayama, Emina; Hata, Junya; Sato, Yuichi; Akaihata, Hidenori; Kataoka, Masao; Ogawa, Soichiro; Uemura, Motohide; Kojima, Yoshiyuki

Year: 2025

Venue: Current Oncology

DOI: https://doi.org/10.3390/curroncol32080467

Paper Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis

Kim, Ju‐Ryoung; Yoo, Jong Jin; Kim, Hyun · 2018 · International Journal of Molecular Sciences · DOI

Full title: Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis

Authors: Kim, Ju‐Ryoung; Yoo, Jong Jin; Kim, Hyun

Year: 2018

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms19030674

Paper Enteric Nervous System Alterations in Inflammatory Bowel Disease: Perspectives and Implications

Suman, Shubhankar · 2024 · Gastrointestinal Disorders · DOI

Full title: Enteric Nervous System Alterations in Inflammatory Bowel Disease: Perspectives and Implications

Authors: Suman, Shubhankar

Year: 2024

Venue: Gastrointestinal Disorders

DOI: https://doi.org/10.3390/gidisord6020025

Paper Inflammation-Accelerated Senescence and the Cardiovascular System: Mechanisms and Perspectives

Pinto, Rita Del; Ferri, Claudio · 2018 · International Journal of Molecular Sciences · DOI

Full title: Inflammation-Accelerated Senescence and the Cardiovascular System: Mechanisms and Perspectives

Authors: Pinto, Rita Del; Ferri, Claudio

Year: 2018

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms19123701

Paper Ageing, Cellular Senescence and Neurodegenerative Disease

Kritsilis, Marios; Rizou, Sophia V.; Koutsoudaki, Paraskevi N. et al. · 2018 · International Journal of Molecular Sciences · DOI

Full title: Ageing, Cellular Senescence and Neurodegenerative Disease

Authors: Kritsilis, Marios; Rizou, Sophia V.; Koutsoudaki, Paraskevi N.; Evangelou, Konstantinos; Gorgoulis, Vassilis G.; Papadopoulos, Dimitrios

Year: 2018

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms19102937

Paper DNA Damage: A Main Determinant of Vascular Aging

Bautista‐Niño, Paula K.; Portilla-Fernández, Eliana; Vaughan, Douglas E. et al. · 2016 · International Journal of Molecular Sciences · DOI

Full title: DNA Damage: A Main Determinant of Vascular Aging

Authors: Bautista‐Niño, Paula K.; Portilla-Fernández, Eliana; Vaughan, Douglas E.; Danser, A.H. Jan; Roks, Anton J.M.

Year: 2016

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms17050748

Paper Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer

Michala, Aikaterini-Spyridoula; Pritsa, Agathi · 2022 · Diseases · DOI

Full title: Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer

Authors: Michala, Aikaterini-Spyridoula; Pritsa, Agathi

Year: 2022

Venue: Diseases

DOI: https://doi.org/10.3390/diseases10030037

Paper Targeting Aging Pathways in Chronic Obstructive Pulmonary Disease

Easter, Molly; Bollenbecker, Seth; Barnes, Jarrod W. et al. · 2020 · International Journal of Molecular Sciences · DOI

Full title: Targeting Aging Pathways in Chronic Obstructive Pulmonary Disease

Authors: Easter, Molly; Bollenbecker, Seth; Barnes, Jarrod W.; Krick, Stefanie

Year: 2020

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms21186924

Paper Epigenetic Basis of Cellular Senescence and Its Implications in Aging

Nacarelli, Timothy; Liu, Pingyu; Zhang, Rugang · 2017 · Genes · DOI

Full title: Epigenetic Basis of Cellular Senescence and Its Implications in Aging

Authors: Nacarelli, Timothy; Liu, Pingyu; Zhang, Rugang

Year: 2017

Venue: Genes

DOI: https://doi.org/10.3390/genes8120343

Paper Treating Senescence like Cancer: Novel Perspectives in Senotherapy of Chronic Diseases

Mongelli, Alessia; Atlante, Sandra; Barbi, Veronica et al. · 2020 · International Journal of Molecular Sciences · DOI

Full title: Treating Senescence like Cancer: Novel Perspectives in Senotherapy of Chronic Diseases

Authors: Mongelli, Alessia; Atlante, Sandra; Barbi, Veronica; Bachetti, Tiziana; Martelli, Fabio; Farsetti, Antonella; Gaetano, Carlo

Year: 2020

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms21217984

Paper The Role of Curcumin in the Modulation of Ageing

Bielak-Żmijewska, Anna; Grabowska, Wioleta; Ciolko, Agata et al. · 2019 · International Journal of Molecular Sciences · DOI

Full title: The Role of Curcumin in the Modulation of Ageing

Authors: Bielak-Żmijewska, Anna; Grabowska, Wioleta; Ciolko, Agata; Bojko, Agnieszka; Mosieniak, Grażyna; Bijoch, Łukasz; Sikora, Ewa

Year: 2019

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms20051239

Paper Alveolar Epithelial Type II Cells as Drivers of Lung Fibrosis in Idiopathic Pulmonary Fibrosis

Parimon, Tanyalak; Yao, Changfu; Stripp, Barry R. et al. · 2020 · International Journal of Molecular Sciences · DOI

Full title: Alveolar Epithelial Type II Cells as Drivers of Lung Fibrosis in Idiopathic Pulmonary Fibrosis

Authors: Parimon, Tanyalak; Yao, Changfu; Stripp, Barry R.; Noble, Paul W.; Chen, Peter

Year: 2020

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms21072269

Paper Control of Mesenchymal Stromal Cell Senescence by Tryptophan Metabolites

Wu, Kenneth K. · 2021 · International Journal of Molecular Sciences · DOI

Full title: Control of Mesenchymal Stromal Cell Senescence by Tryptophan Metabolites

Authors: Wu, Kenneth K.

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms22020697

Paper Cellular Senescence in Lung Fibrosis

Hernández‐González, Fernanda; Faner, Rosa; Rojas, Mauricio et al. · 2021 · International Journal of Molecular Sciences · DOI

Full title: Cellular Senescence in Lung Fibrosis

Authors: Hernández‐González, Fernanda; Faner, Rosa; Rojas, Mauricio; Agustí, Àlvar; Serrano, Manuel; Sellarés, Jacobo

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms22137012

Paper Natural Polyphenols Targeting Senescence: A Novel Prevention and Therapy Strategy for Cancer

Bian, Yan; Wei, Juntong; Zhao, Changsheng et al. · 2020 · International Journal of Molecular Sciences · DOI

Full title: Natural Polyphenols Targeting Senescence: A Novel Prevention and Therapy Strategy for Cancer

Authors: Bian, Yan; Wei, Juntong; Zhao, Changsheng; Li, Guorong

Year: 2020

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms21020684

Paper Stiffness and Aging in Cardiovascular Diseases: The Dangerous Relationship between Force and Senescence

Ferrari, Silvia; Pesce, Maurizio · 2021 · International Journal of Molecular Sciences · DOI

Full title: Stiffness and Aging in Cardiovascular Diseases: The Dangerous Relationship between Force and Senescence

Authors: Ferrari, Silvia; Pesce, Maurizio

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms22073404

Paper Cellular Senescence: Pathogenic Mechanisms in Lung Fibrosis

Parimon, Tanyalak; Hohmann, M.; Yao, Changfu · 2021 · International Journal of Molecular Sciences · DOI

Full title: Cellular Senescence: Pathogenic Mechanisms in Lung Fibrosis

Authors: Parimon, Tanyalak; Hohmann, M.; Yao, Changfu

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms22126214

Paper Skeletal Aging and Osteoporosis: Mechanisms and Therapeutics

Chandra, Abhishek; Rajawat, Jyotika · 2021 · International Journal of Molecular Sciences · DOI

Full title: Skeletal Aging and Osteoporosis: Mechanisms and Therapeutics

Authors: Chandra, Abhishek; Rajawat, Jyotika

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms22073553

Paper Cascade of Inflammatory, Fibrotic Processes, and Stress-Induced Senescence in Chronic GVHD-Related Dry Eye Disease.

Ogawa, Yoko; Kawakami, Yutaka; Tsubota, Kazuo · 2021 · International journal of molecular sciences · DOI

Full title: Cascade of Inflammatory, Fibrotic Processes, and Stress-Induced Senescence in Chronic GVHD-Related Dry Eye Disease.

Authors: Ogawa, Yoko; Kawakami, Yutaka; Tsubota, Kazuo

Year: 2021

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms22116114

Paper Flavonoids in Skin Senescence Prevention and Treatment

A. Domaszewska-Szostek; M. Puzianowska-Kuźnicka; A. Kuryłowicz · 2021 · International Journal of Molecular Sciences · DOI

Full title: Flavonoids in Skin Senescence Prevention and Treatment

Authors: A. Domaszewska-Szostek; M. Puzianowska-Kuźnicka; A. Kuryłowicz

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms22136814

Paper Skin Aging, Cellular Senescence and Natural Polyphenols

Csekes, Erika; Račková, Lucia · 2021 · International Journal of Molecular Sciences · DOI

Full title: Skin Aging, Cellular Senescence and Natural Polyphenols

Authors: Csekes, Erika; Račková, Lucia

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms222312641

Paper NGAL as a Potential Target in Tumor Microenvironment

Crescenzi, Elvira; Leonardi, Antonio; Pacifico, Francesco · 2021 · International Journal of Molecular Sciences · DOI

Full title: NGAL as a Potential Target in Tumor Microenvironment

Authors: Crescenzi, Elvira; Leonardi, Antonio; Pacifico, Francesco

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms222212333

Paper Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake

Rysz, Jacek; Franczyk, Beata; Rysz-Górzyńska, Magdalena et al. · 2021 · International Journal of Molecular Sciences · DOI

Full title: Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake

Authors: Rysz, Jacek; Franczyk, Beata; Rysz-Górzyńska, Magdalena; Gluba-Brzózka, Anna

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms23010183

Paper Senolytic Therapy for Cerebral Ischemia-Reperfusion Injury

Lim, Songhyun; Kim, Tae Jung; Kim, Young Ju et al. · 2021 · International Journal of Molecular Sciences · DOI

Full title: Senolytic Therapy for Cerebral Ischemia-Reperfusion Injury

Authors: Lim, Songhyun; Kim, Tae Jung; Kim, Young Ju; Kim, Cheesue; Ko, Sang‐Bae; Kim, Byung-Soo

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms222111967

Paper Biochemical and Cellular Characterization of New Radio-Resistant Cell Lines Reveals a Role of Natural Flavonoids to Bypass Senescence

Russo, Maria; Spagnuolo, Carmela; Moccia, Stefania et al. · 2021 · International Journal of Molecular Sciences · DOI

Full title: Biochemical and Cellular Characterization of New Radio-Resistant Cell Lines Reveals a Role of Natural Flavonoids to Bypass Senescence

Authors: Russo, Maria; Spagnuolo, Carmela; Moccia, Stefania; Tedesco, Idolo; Lauria, Fabio; Russo, Gian Luigi

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms23010301

Paper Inflammation, Oxidative Stress, Senescence in Atherosclerosis: Thioredoxine-1 as an Emerging Therapeutic Target

Hadri, Khadija El; Smith, Rémy; Duplus, Eric et al. · 2021 · International Journal of Molecular Sciences · DOI

Full title: Inflammation, Oxidative Stress, Senescence in Atherosclerosis: Thioredoxine-1 as an Emerging Therapeutic Target

Authors: Hadri, Khadija El; Smith, Rémy; Duplus, Eric; Amri, Chahrazade El

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms23010077

Paper Flavonoids—Natural Gifts to Promote Health and Longevity

Fan, Xiaolan; Fan, Ziqiang; Yang, Ziyue et al. · 2022 · International Journal of Molecular Sciences · DOI

Full title: Flavonoids—Natural Gifts to Promote Health and Longevity

Authors: Fan, Xiaolan; Fan, Ziqiang; Yang, Ziyue; Huang, Tiantian; Tong, Yingdong; Yang, Deying; Mao, Xueping; Yang, Mingyao

Year: 2022

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms23042176

Paper Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs

Kudlová, Natálie; Sanctis, Juan Bautista De; Hajdúch, Marián · 2022 · International Journal of Molecular Sciences · DOI

Full title: Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs

Authors: Kudlová, Natálie; Sanctis, Juan Bautista De; Hajdúch, Marián

Year: 2022

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms23084168

Paper A Small Molecule That Promotes Cellular Senescence Prevents Fibrogenesis and Tumorigenesis

Meang, Moon Kee; Kim, Saesbyeol; Kim, Ik Hwan et al. · 2022 · International Journal of Molecular Sciences · DOI

Full title: A Small Molecule That Promotes Cellular Senescence Prevents Fibrogenesis and Tumorigenesis

Authors: Meang, Moon Kee; Kim, Saesbyeol; Kim, Ik Hwan; Kim, Han-Soo; Youn, Byung‐Soo

Year: 2022

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms23126852

Paper Identifying Novel Osteoarthritis-Associated Genes in Human Cartilage Using a Systematic Meta-Analysis and a Multi-Source Integrated Network

Shorter, Emily; Avelar, Roberto A.; Zachariou, Margarita et al. · 2022 · International Journal of Molecular Sciences · DOI

Full title: Identifying Novel Osteoarthritis-Associated Genes in Human Cartilage Using a Systematic Meta-Analysis and a Multi-Source Integrated Network

Authors: Shorter, Emily; Avelar, Roberto A.; Zachariou, Margarita; Spyrou, George M.; Raina, Priyanka; Smagul, Aibek; Kharaz, Yalda A.; Peffers, Mandy J.; Goljanek-Whysall, Kasia; Magalhães, João Pedro de; Poulet, B.

Year: 2022

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms23084395

Paper Cellular Senescence in Immunity against Infections

Marrella, Veronica; Facoetti, Amanda; Cassani, Barbara · 2022 · International Journal of Molecular Sciences · DOI

Full title: Cellular Senescence in Immunity against Infections

Authors: Marrella, Veronica; Facoetti, Amanda; Cassani, Barbara

Year: 2022

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms231911845

Paper Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis.

Weng, Pei-Wei; Pikatan, Narpati Wesa; Setiawan, Syahru Agung et al. · 2022 · International journal of molecular sciences · DOI

Full title: Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis.

Authors: Weng, Pei-Wei; Pikatan, Narpati Wesa; Setiawan, Syahru Agung; Yadav, Vijesh Kumar; Fong, Iat-Hang; Hsu, Chia-Hung; Yeh, Chi-Tai; Lee, Wei-Hwa

Year: 2022

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms23137043

Paper Therapeutics That Can Potentially Replicate or Augment the Anti-Aging Effects of Physical Exercise

Lages, Adriana; Lopes, Valentim; Horta, João et al. · 2022 · International Journal of Molecular Sciences · DOI

Full title: Therapeutics That Can Potentially Replicate or Augment the Anti-Aging Effects of Physical Exercise

Authors: Lages, Adriana; Lopes, Valentim; Horta, João; Espregueira‐Mendes, João; Andrade, Renato; Rebelo‐Marques, Alexandre

Year: 2022

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms23179957

Paper Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge

Effendi, Wiwin Is; Nagano, Tatsuya · 2022 · International Journal of Molecular Sciences · DOI

Full title: Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge

Authors: Effendi, Wiwin Is; Nagano, Tatsuya

Year: 2022

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms23116064

Paper Structural and Functional Changes in Aging Kidneys

Dybiec, Jill; Szlagor, Magdalena; Młynarska, Ewelina et al. · 2022 · International Journal of Molecular Sciences · DOI

Full title: Structural and Functional Changes in Aging Kidneys

Authors: Dybiec, Jill; Szlagor, Magdalena; Młynarska, Ewelina; Rysz, Jacek; Franczyk, Beata

Year: 2022

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms232315435

Paper Senolytic Therapy: A Potential Approach for the Elimination of Oncogene-Induced Senescent HPV-Positive Cells

Saleh, Tareq; Khasawneh, Ashraf I.; Himsawi, Nisreen et al. · 2022 · International Journal of Molecular Sciences · DOI

Full title: Senolytic Therapy: A Potential Approach for the Elimination of Oncogene-Induced Senescent HPV-Positive Cells

Authors: Saleh, Tareq; Khasawneh, Ashraf I.; Himsawi, Nisreen; Abu-Raideh, Jumana; Ejeilat, Vera; Elshazly, Ahmed M.; Gewirtz, David A.

Year: 2022

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms232415512

Paper Inflammaging and Immunosenescence as Part of Skin Aging-A Narrative Review.

Pająk, Justyna; Nowicka, Danuta; Szepietowski, Jacek C · 2023 · International journal of molecular sciences · DOI

Full title: Inflammaging and Immunosenescence as Part of Skin Aging-A Narrative Review.

Authors: Pająk, Justyna; Nowicka, Danuta; Szepietowski, Jacek C

Year: 2023

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms24097784

Paper Ferroptosis and Senescence: A Systematic Review

Coradduzza, Donatella; Congiargiu, Antonella; Chen, Zhichao et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: Ferroptosis and Senescence: A Systematic Review

Authors: Coradduzza, Donatella; Congiargiu, Antonella; Chen, Zhichao; Zinellu, Angelo; Carru, Ciriaco; Medici, Serenella

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms24043658

Paper The Effects of Nutrient Signaling Regulators in Combination with Phytocannabinoids on the Senescence-Associated Phenotype in Human Dermal Fibroblasts

Gerasymchuk, Marta; Robinson, Gregory Ian; Kovalchuk, Olga et al. · 2022 · International Journal of Molecular Sciences · DOI

Full title: The Effects of Nutrient Signaling Regulators in Combination with Phytocannabinoids on the Senescence-Associated Phenotype in Human Dermal Fibroblasts

Authors: Gerasymchuk, Marta; Robinson, Gregory Ian; Kovalchuk, Olga; Kovalchuk, Igor

Year: 2022

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms23158804

Paper The Effects of Fisetin on Cyclosporine-Treated Dry Eye Disease in Dogs

Krajčíková, Kristína; Balická, Agnieszka; Lapšanská, Mária et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: The Effects of Fisetin on Cyclosporine-Treated Dry Eye Disease in Dogs

Authors: Krajčíková, Kristína; Balická, Agnieszka; Lapšanská, Mária; Trbolová, A.; Guľašová, Zuzana; Kondrakhova, Dária; Komanický, Vladimír; Rašiová, Adriána; Tomečková, Vladimı́ra

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms24021488

Paper Generation of a p21 Reporter Mouse and Its Use to Identify and Eliminate p21high Cells In Vivo

Yi, Zimei; Le, Ren; Wei, Yu et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: Generation of a p21 Reporter Mouse and Its Use to Identify and Eliminate p21high Cells In Vivo

Authors: Yi, Zimei; Le, Ren; Wei, Yu; Chen, Siyi; Zhao, Jiechen; Zhu, Jiayu; Wu, Junhua

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms24065565

Paper Targeting Multiple Homeostasis-Maintaining Systems by Ionophore Nigericin Is a Novel Approach for Senolysis.

Deryabin, Pavel I; Shatrova, Alla N; Borodkina, Aleksandra V · 2022 · International journal of molecular sciences · DOI

Full title: Targeting Multiple Homeostasis-Maintaining Systems by Ionophore Nigericin Is a Novel Approach for Senolysis.

Authors: Deryabin, Pavel I; Shatrova, Alla N; Borodkina, Aleksandra V

Year: 2022

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms232214251

Paper Aging of Liver in Its Different Diseases

Radonjić, Tijana; Dukić, Marija; Jovanović, Igor et al. · 2022 · International Journal of Molecular Sciences · DOI

Full title: Aging of Liver in Its Different Diseases

Authors: Radonjić, Tijana; Dukić, Marija; Jovanović, Igor; Zdravković, Marija; Mandić, Olga; Popadić, Višeslav; Popović, Maja; Nikolić, Novica; Klašnja, Slobodan; Divac, Anica; Todorović, Zoran; Branković, Marija

Year: 2022

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms232113085

Paper Senescence of Tumor Cells in Anticancer Therapy-Beneficial and Detrimental Effects.

Piskorz, Wiktoria Monika; Cechowska-Pasko, Marzanna · 2022 · International journal of molecular sciences · DOI

Full title: Senescence of Tumor Cells in Anticancer Therapy-Beneficial and Detrimental Effects.

Authors: Piskorz, Wiktoria Monika; Cechowska-Pasko, Marzanna

Year: 2022

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms231911082

Paper Impact of Senolytic Treatment on Gene Expression in Aged Lung

Cho, Soo Jung; Pronko, Alexander; Yang, Jianjun et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: Impact of Senolytic Treatment on Gene Expression in Aged Lung

Authors: Cho, Soo Jung; Pronko, Alexander; Yang, Jianjun; Stout-Delgado, Heather W.

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms24087628

Paper Ketogenic diet induces p53-dependent cellular senescence in multiple organs

Sung-Jen Wei; Joseph R Schell; E. S. Chocron et al. · 2024 · Science Advances · DOI

Full title: Ketogenic diet induces p53-dependent cellular senescence in multiple organs

Authors: Sung-Jen Wei; Joseph R Schell; E. S. Chocron; Mahboubeh Varmazyad; Guogang Xu; Wan Hsi Chen; Gloria M Martinez; Felix F Dong; Prethish Sreenivas; Rolando Trevino; Haiyan Jiang; Yan Du; A. Saliba; Wei Qian; Brandon Lorenzana; Alia Nazarullah; Jenny Chang; Kumar Sharma; Erin Munkácsy; Nobuo Horikoshi; David Gius

Year: 2024

Venue: Science Advances

DOI: https://doi.org/10.1126/sciadv.ado1463

Paper Senolytic Treatment for Low Back Pain

M. Mannarino; Hosni Cherif; Saber Ghazizadeh et al. · 2024 · bioRxiv · DOI

Full title: Senolytic Treatment for Low Back Pain

Authors: M. Mannarino; Hosni Cherif; Saber Ghazizadeh; Oliver Wu Martinez; Kai Sheng; Elsa Cousineau; Seunghwan Lee; M. Millecamps; Chan Gao; Jean A. Ouellet; Laura S Stone; L. Haglund

Year: 2024

Venue: bioRxiv

DOI: https://doi.org/10.1101/2024.01.15.575738

Paper 106 Senescence as a therapeutic target for myocardial ageing

Anna Walaszczyk; Emily Dookun; R. Redgrave et al. · 2018 · Basic Science · DOI

Full title: 106 Senescence as a therapeutic target for myocardial ageing

Authors: Anna Walaszczyk; Emily Dookun; R. Redgrave; Simon Tual-Chalot; Rhys K. Anderson; I. Spyridopoulos; Andrew W. Owens; H. Arthur; G. Richardson; J. Passos

Year: 2018

Venue: Basic Science

Paper Senolytics reduce coronavirus-related mortality in old mice

Christina D. Camell; Matthew J. Yousefzadeh; Yi Zhu et al. · 2021 · Science · DOI

Full title: Senolytics reduce coronavirus-related mortality in old mice

Authors: Christina D. Camell; Matthew J. Yousefzadeh; Yi Zhu; L. Prata; M. Huggins; Mark J Pierson; Lei Zhang; Ryan D. O’Kelly; T. Pirtskhalava; P. Xun; K. Ejima; A. Xue; Utkarsh Tripathi; J. Espindola-Netto; N. Giorgadze; E. Atkinson; C. Inman; Kurt O. Johnson; Stephanie H. Cholensky; Timothy W. Carlson; N. LeBrasseur; S. Khosla; M. G. O’Sullivan; D. B. Allison; S. Jameson; A. Meves; Ming Li; Y. Prakash; S. Chiarella; Sara E. Hamilton; T. Tchkonia; L. Niedernhofer; J. Kirkland; P. Robbins

Year: 2021

Venue: Science

DOI: https://doi.org/10.1126/science.abe4832

Paper Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human

Jason D. Roh; Claire Castro; Andy Yu et al. · 2024 · Science Translational Medicine · DOI

Full title: Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human

Authors: Jason D. Roh; Claire Castro; Andy Yu; Sarosh Rana; S. Shahul; Kathryn J Gray; M. Honigberg; M. Ricke-Hoch; Yoshiko Iwamoto; Ashish S. Yeri; Robert Kitchen; J. Guerra; Ryan Hobson; Vinita Chaudhari; Bliss Chang; Amy Sarma; Carolin Lerchenmüller; Z. A. Al Sayed; Carmen Diaz Verdugo; Peng Xia; Niv Skarbianskis; Amit Zeisel; J. Bauersachs; James L. Kirkland; S. Karumanchi; John Gorcsan; Masataka Sugahara; Julie Damp; K. Hanley-Yanez; P. Ellinor; Zoltan Arany; Dennis M. McNamara; D. Hilfiker-Kleiner; Anthony Rosenzweig; J. Fett; J. Pisarcik; Charles McTiernan; Erik Schelbert; Rami Alharethi; Kismet Rasmusson; Kim Brunisholz; A. Butler; D. Budge; A. G. Kfoury; Benjamin Horne; Joe Tuinei; Heather Brown; A. Naftilan; Jill Russell; D. Freehardt; Eileen Hsich; Cynthia Oblak; Gregory Ewald; Donna Whitehead; Jean Flanagan; A. Platts; Uri Elkayam; J. Caro; Stephanie Mullin; M. Givertz; M. S. Anello; N. Rajagopalan; David Booth; Tiffany Sandlin; W. Wijesiri; Leslie T Cooper; L. Blauwet; Joann Brunner; Mary Phelps; Ruth Kempf; K. Modi; Tracy Norwood; Joan Briller; D. Griza; G. Felker; R. Kociol; Patricia Adams; Gretchen Wells; V. Thohan; Deborah J Wesley-Farrington; Sandra Soots; R. Sheppard; Caroline Michel; Nathalie Lapointe; Heather Nathaniel; A. Kealey; M. Semigran; Maureen Daher; J. Boehmer; David Silber; Eric D. Popjes; Patricia Frey; T. Nicklas; Jeffrey D. Alexis; Lori Caufield; J. Thornton; Mindy Gentry; Vincent J. B. Robinson; Gyanendra K. Sharma; Joan Holloway; Maria Powell; David Markham; Mark H. Drazner; Lynn Fernandez; Mark Zucker; David A. Baran; M. Gimovsky; Natalia Hochbaum; Bharati Patel; Laura Adams; Gautam Ramani; Stephen S Gottlieb; Shawn Robinson; Stacy Fisher; Joanne Marshall; J. Haythe; D. Mancini; R. Bijou; M. Farr; Mary V. Marks; Henry Arango; Biykem Bozkurt; M. Bolos; Paul Mather; Sharon Rubin; Raphael Bonita; Susan Eberwine; H. Skopicki; K. Stergiopoulos; Ellen McCathy-Santoro; Jennifer Intravaia; Elizabeth Maas; Jordan G Safirstein; A. Kleet; Nancy Martinez; Christine Corpoin; Donna Hesari; Sandra Chaparro; Laura J. Hudson; Jalal K. Ghali; Zora Injic; I. Wittstein

Year: 2024

Venue: Science Translational Medicine

DOI: https://doi.org/10.1126/scitranslmed.adi0077

Paper Current Trends in Anti-Aging Strategies

Rosén, Robert; Yarmush, Martin L. · 2023 · Annual Review of Biomedical Engineering · DOI

Full title: Current Trends in Anti-Aging Strategies

Authors: Rosén, Robert; Yarmush, Martin L.

Year: 2023

Venue: Annual Review of Biomedical Engineering

DOI: https://doi.org/10.1146/annurev-bioeng-120122-123054

Paper Senolytics reduce endothelial cell DNA damage and telomere dysfunction in old age

Samuel I. Bloom; Eric Tuday; M. Islam et al. · 2023 · Physiology · DOI

Full title: Senolytics reduce endothelial cell DNA damage and telomere dysfunction in old age

Authors: Samuel I. Bloom; Eric Tuday; M. Islam; V. Gogulamudi; L. Lesniewski; A. Donato

Year: 2023

Venue: Physiology

DOI: https://doi.org/10.1152/physiol.2023.38.s1.5733289

Paper Agents for healthful aging

Gemma K. Alderton · 2019 · Science · DOI

Full title: Agents for healthful aging

Authors: Gemma K. Alderton

Year: 2019

Venue: Science

DOI: https://doi.org/10.1126/science.364.6441.645-s

Paper Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span.

Robbins, Paul D; Jurk, Diana; Khosla, Sundeep et al. · 2021 · Annual review of pharmacology and toxicology · DOI

Full title: Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span.

Authors: Robbins, Paul D; Jurk, Diana; Khosla, Sundeep; Kirkland, James L; LeBrasseur, Nathan K; Miller, Jordan D; Passos, João F; Pignolo, Robert J; Tchkonia, Tamar; Niedernhofer, Laura J

Year: 2021

Venue: Annual review of pharmacology and toxicology

DOI: https://doi.org/10.1146/annurev-pharmtox-050120-105018

Paper Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace

Hecker, Louise · 2018 · American Journal of Physiology-Lung Cellular and Molecular Physiology · DOI

Full title: Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace

Authors: Hecker, Louise

Year: 2018

Venue: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: https://doi.org/10.1152/ajplung.00275.2017

Paper Transplanted senescent renal scattered tubular-like cells induce injury in the mouse kidney.

Seo Rin Kim; Kai Jiang; Christopher M. Ferguson et al. · 2020 · AJP - Renal Physiology · DOI

Full title: Transplanted senescent renal scattered tubular-like cells induce injury in the mouse kidney.

Authors: Seo Rin Kim; Kai Jiang; Christopher M. Ferguson; Hui Tang; Xiaojun Chen; Xiang-Yang Zhu; L. Hickson; T. Tchkonia; J. Kirkland; L. Lerman

Year: 2020

Venue: AJP - Renal Physiology

DOI: https://doi.org/10.1152/ajprenal.00535.2019

Paper Cellular senescence mediates doxorubicin chemotherapy-induced vascular endothelial dysfunction: translational evidence of prevention with senolytic treatment.

Venkatasubramanian, Ravinandan; Mahoney, Sophia A; Hutton, David A et al. · 2025 · American journal of physiology. Heart and circulatory physiology · DOI

Full title: Cellular senescence mediates doxorubicin chemotherapy-induced vascular endothelial dysfunction: translational evidence of prevention with senolytic treatment.

Authors: Venkatasubramanian, Ravinandan; Mahoney, Sophia A; Hutton, David A; VanDongen, Nicholas S; Brunt, Vienna E; Greenberg, Nathan T; Longtine, Abigail G; Brandt, Lukas; Beyer, Andreas M; Melov, Simon; Rossman, Matthew J; Seals, Douglas R; Clayton, Zachary S

Year: 2025

Venue: American journal of physiology. Heart and circulatory physiology

DOI: https://doi.org/10.1152/ajpheart.00712.2025

Paper Single Cell Profiling Reveals Unique Contributions of Senescent Macrophages across Musculoskeletal Tissues in Posttraumatic Osteoarthritis

Allison Owen; Alexander R Keeble; Nicholas Thomas et al. · 2024 · Physiology · DOI

Full title: Single Cell Profiling Reveals Unique Contributions of Senescent Macrophages across Musculoskeletal Tissues in Posttraumatic Osteoarthritis

Authors: Allison Owen; Alexander R Keeble; Nicholas Thomas; Peyton J. Balawender; Camille Brightwell; Brian Noehren; Cory Dungan

Year: 2024

Venue: Physiology

DOI: https://doi.org/10.1152/physiol.2024.39.s1.1544

Paper Cellular senescence in the lung across the age spectrum.

Parikh, Pavan; Wicher, Sarah; Khandalavala, Karl et al. · 2019 · American journal of physiology. Lung cellular and molecular physiology · DOI

Full title: Cellular senescence in the lung across the age spectrum.

Authors: Parikh, Pavan; Wicher, Sarah; Khandalavala, Karl; Pabelick, Christina M; Britt, Rodney D; Prakash, Y S

Year: 2019

Venue: American journal of physiology. Lung cellular and molecular physiology

DOI: https://doi.org/10.1152/ajplung.00424.2018

Paper Cellular Senescence and Inter-Organ Communication in Health and Disease.

Zhang, Yang; Chi, Xinyue; Zhou, Qiulian et al. · 2025 · Physiology (Bethesda, Md.) · DOI

Full title: Cellular Senescence and Inter-Organ Communication in Health and Disease.

Authors: Zhang, Yang; Chi, Xinyue; Zhou, Qiulian; Huang, Shengyuan; Chen, Hou-Zao; Rosenzweig, Anthony

Year: 2025

Venue: Physiology (Bethesda, Md.)

DOI: https://doi.org/10.1152/physiol.00017.2025

Paper Recent Advances in Senolysis for Age-Related Diseases.

Aratani, Sae; Nakanishi, Makoto · 2023 · Physiology (Bethesda, Md.) · DOI

Full title: Recent Advances in Senolysis for Age-Related Diseases.

Authors: Aratani, Sae; Nakanishi, Makoto

Year: 2023

Venue: Physiology (Bethesda, Md.)

DOI: https://doi.org/10.1152/physiol.00003.2023

Paper Cellular Senescence: Aging, Cancer, and Injury

Calcinotto, Arianna; Kohli, Jaskaren; Zagato, Elena et al. · 2019 · Physiological Reviews · DOI

Full title: Cellular Senescence: Aging, Cancer, and Injury

Authors: Calcinotto, Arianna; Kohli, Jaskaren; Zagato, Elena; Pellegrini, Laura; Demaria, Marco; Alimonti, Andrea

Year: 2019

Venue: Physiological Reviews

DOI: https://doi.org/10.1152/physrev.00020.2018

Paper Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy

Malavolta, Marco; Bracci, Massimo; Santarelli, Lory et al. · 2018 · Mediators of Inflammation · DOI

Full title: Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy

Authors: Malavolta, Marco; Bracci, Massimo; Santarelli, Lory; Sayeed, Md. Abu; Pierpaoli, Elisa; Giacconi, Robertina; Costarelli, Laura; Piacenza, Francesco; Basso, Andrea; Cardelli, Maurizio; Provinciali, Mauro

Year: 2018

Venue: Mediators of Inflammation

DOI: https://doi.org/10.1155/2018/4159013

Paper Clearing Senescent Endothelial Cells with Senolytics Restores Replicative Capacity

Hossein Abdeahad; Samuel I. Bloom; Denisse G Moreno et al. · 2025 · Physiology · DOI

Full title: Clearing Senescent Endothelial Cells with Senolytics Restores Replicative Capacity

Authors: Hossein Abdeahad; Samuel I. Bloom; Denisse G Moreno; Hui Huang; Lisa A Lesniewski; Anthony J Donato

Year: 2025

Venue: Physiology

DOI: https://doi.org/10.1152/physiol.2025.40.s1.1570

Paper GPX4 Over-expression Is Associated with Increased Senescence Burden and Metabolic Dysfunction

Shelby A Hall; John Kim; M. Nielsen et al. · 2024 · Physiology · DOI

Full title: GPX4 Over-expression Is Associated with Increased Senescence Burden and Metabolic Dysfunction

Authors: Shelby A Hall; John Kim; M. Nielsen; Chase Johansen; Jisok Lim; Anthony J Donato; Lisa A Lesniewski

Year: 2024

Venue: Physiology

DOI: https://doi.org/10.1152/physiol.2024.39.s1.1782

Paper The Role Of Senolytics In Reducing Senescence Induced By Cannabinoids And Nicotine In Prenatal Human Lung

I. El Alam; R. Belgacemi; I. Glass et al. · 2025 · Physiology · DOI

Full title: The Role Of Senolytics In Reducing Senescence Induced By Cannabinoids And Nicotine In Prenatal Human Lung

Authors: I. El Alam; R. Belgacemi; I. Glass; E. Zana-Taeib; I. El Alam; Laurent Boyer; V. Rehan; Y. Prakash; C. Pabelick; Soula Danopoulos; Denise Al Alam

Year: 2025

Venue: Physiology

DOI: https://doi.org/10.1152/physiol.2025.40.s1.1566

Paper Fisetin supplementation targets senescent endothelial cells in old mice and prevents plasma-induced endothelial dysfunction with aging

S. Mahoney; K. Mazan-Mamczarz; Dimitrios Tsitsipatis et al. · 2025 · Physiology · DOI

Full title: Fisetin supplementation targets senescent endothelial cells in old mice and prevents plasma-induced endothelial dysfunction with aging

Authors: S. Mahoney; K. Mazan-Mamczarz; Dimitrios Tsitsipatis; Nicholas S. VanDongen; Matthew J. Rossman; Douglas R. Seals; Allison Herman; Zachary S. Clayton

Year: 2025

Venue: Physiology

DOI: https://doi.org/10.1152/physiol.2025.40.s1.0657

Paper Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases

Zhou, Yi; Zhu, Lin; Yuan, Yunyun et al. · 2020 · Oxidative Medicine and Cellular Longevity · DOI

Full title: Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases

Authors: Zhou, Yi; Zhu, Lin; Yuan, Yunyun; Ling, Shuang; Xu, Jin‐Wen

Year: 2020

Venue: Oxidative Medicine and Cellular Longevity

DOI: https://doi.org/10.1155/2020/2128513

Paper The Emerging Role of Senescence in Ocular Disease.

Sreekumar, Parameswaran G; Hinton, David R; Kannan, Ram · 2020 · Oxidative medicine and cellular longevity · DOI

Full title: The Emerging Role of Senescence in Ocular Disease.

Authors: Sreekumar, Parameswaran G; Hinton, David R; Kannan, Ram

Year: 2020

Venue: Oxidative medicine and cellular longevity

DOI: https://doi.org/10.1155/2020/2583601

Paper Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell Senescence

Abruzzo, Provvidenza Maria; Canaider, Silvia; Pizzuti, Valeria et al. · 2020 · Stem Cells International · DOI

Full title: Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell Senescence

Authors: Abruzzo, Provvidenza Maria; Canaider, Silvia; Pizzuti, Valeria; Pampanella, Luca; Casadei, Raffaella; Facchin, Federica; Ventura, Carlo

Year: 2020

Venue: Stem Cells International

DOI: https://doi.org/10.1155/2020/8827038

Paper Network Pharmacology Analysis to Identify Phytochemicals in Traditional Chinese Medicines That May Regulate ACE2 for the Treatment of COVID‐19

Niu, Wenhao; Wu, Feng; Cui, Haiming et al. · 2020 · Evidence-based Complementary and Alternative Medicine · DOI

Full title: Network Pharmacology Analysis to Identify Phytochemicals in Traditional Chinese Medicines That May Regulate ACE2 for the Treatment of COVID‐19

Authors: Niu, Wenhao; Wu, Feng; Cui, Haiming; Cao, Wenyue; Chao, Yu-Chieh; Wu, Zonggui; Fan, Min; Liang, Chun

Year: 2020

Venue: Evidence-based Complementary and Alternative Medicine

DOI: https://doi.org/10.1155/2020/7493281

Paper Current Progress in the Rejuvenation of Aging Stem/Progenitor Cells for Improving the Therapeutic Effectiveness of Myocardial Repair

Kaur, Gurleen; Cai, Chuanxi · 2018 · Stem Cells International · DOI

Full title: Current Progress in the Rejuvenation of Aging Stem/Progenitor Cells for Improving the Therapeutic Effectiveness of Myocardial Repair

Authors: Kaur, Gurleen; Cai, Chuanxi

Year: 2018

Venue: Stem Cells International

DOI: https://doi.org/10.1155/2018/9308301

Paper Pharmacological Approaches to Decelerate Aging: A Promising Path

Hassani, Bahareh; Goshtasbi, Ghazal; Nooraddini, Shirin et al. · 2022 · Oxidative Medicine and Cellular Longevity · DOI

Full title: Pharmacological Approaches to Decelerate Aging: A Promising Path

Authors: Hassani, Bahareh; Goshtasbi, Ghazal; Nooraddini, Shirin; Firouzabadi, Negar

Year: 2022

Venue: Oxidative Medicine and Cellular Longevity

DOI: https://doi.org/10.1155/2022/4201533

Paper One‐Two Punch Therapy for the Treatment of T‐Cell Malignancies Involving p53‐Dependent Cellular Senescence

Qing, Yingjie; Li, Hui; Zhao, Yunzi et al. · 2021 · Oxidative Medicine and Cellular Longevity · DOI

Full title: One‐Two Punch Therapy for the Treatment of T‐Cell Malignancies Involving p53‐Dependent Cellular Senescence

Authors: Qing, Yingjie; Li, Hui; Zhao, Yunzi; Hu, Po; Wang, Xiangyuan; Yu, Xiaoxuan; Zhu, Mengyuan; Wang, Hongzheng; Wang, Zhanyu; Guo, Qinglong; Hui, Hui

Year: 2021

Venue: Oxidative Medicine and Cellular Longevity

DOI: https://doi.org/10.1155/2021/5529518

Paper Biological Activities Underlying the Therapeutic Effect of Quercetin on Inflammatory Bowel Disease

Lyu, Yongli; Zhou, Haifeng; Yang, Jia et al. · 2022 · Mediators of Inflammation · DOI

Full title: Biological Activities Underlying the Therapeutic Effect of Quercetin on Inflammatory Bowel Disease

Authors: Lyu, Yongli; Zhou, Haifeng; Yang, Jia; Wang, Faxi; Sun, Fei; Li, Junyi

Year: 2022

Venue: Mediators of Inflammation

DOI: https://doi.org/10.1155/2022/5665778

Paper Senotherapy Protects against Cisplatin-Induced Ovarian Injury by Removing Senescent Cells and Alleviating DNA Damage

Dingfu Du; Xianan Tang; Yufeng Li et al. · 2022 · Oxidative Medicine and Cellular Longevity · DOI

Full title: Senotherapy Protects against Cisplatin-Induced Ovarian Injury by Removing Senescent Cells and Alleviating DNA Damage

Authors: Dingfu Du; Xianan Tang; Yufeng Li; Yueyue Gao; Runhua Chen; Qian Chen; Jingyi Wen; Tong Wu; Yan Zhang; Huan Lu; Jinjin Zhang; Shixuan Wang

Year: 2022

Venue: Oxidative Medicine and Cellular Longevity

DOI: https://doi.org/10.1155/2022/9144644

Paper BCL-xL Targeting to Induce Apoptosis and to Eliminate Chemotherapy-Induced Senescent Tumor Cells: From Navitoclax to Platelet-Sparing BCL-xL PROTACs

Skwarska, Anna; Konopleva, Marina · 2023 · Cancer Research · DOI

Full title: BCL-xL Targeting to Induce Apoptosis and to Eliminate Chemotherapy-Induced Senescent Tumor Cells: From Navitoclax to Platelet-Sparing BCL-xL PROTACs

Authors: Skwarska, Anna; Konopleva, Marina

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/0008-5472.can-23-2804

Paper Dihydroartemisinin Attenuated Intervertebral Disc Degeneration via Inhibiting PI3K/AKT and NF‐κB Signaling Pathways

Liao, Zhiheng; Su, Deying; Liu, Hengyu et al. · 2022 · Oxidative Medicine and Cellular Longevity · DOI

Full title: Dihydroartemisinin Attenuated Intervertebral Disc Degeneration via Inhibiting PI3K/AKT and NF‐κB Signaling Pathways

Authors: Liao, Zhiheng; Su, Deying; Liu, Hengyu; Xu, Caixia; Wu, Jinna; Chen, Yuyu; Guo, Weimin; Zhang, Shun; Li, Zhuling; Ke, Xiaona; Wang, Tingting; Zhou, Taifeng; Su, Peiqiang

Year: 2022

Venue: Oxidative Medicine and Cellular Longevity

DOI: https://doi.org/10.1155/2022/8672969

Paper Therapy-Induced Senescence Drives Bone Loss.

Yao, Zhangting; Murali, Bhavna; Ren, Qihao et al. · 2020 · Cancer research · DOI

Full title: Therapy-Induced Senescence Drives Bone Loss.

Authors: Yao, Zhangting; Murali, Bhavna; Ren, Qihao; Luo, Xianmin; Faget, Douglas V; Cole, Tom; Ricci, Biancamaria; Thotala, Dinesh; Monahan, Joseph; van Deursen, Jan M; Baker, Darren; Faccio, Roberta; Schwarz, Julie K; Stewart, Sheila A

Year: 2020

Venue: Cancer research

DOI: https://doi.org/10.1158/0008-5472.CAN-19-2348

Paper Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence.

Fletcher-Sananikone, Eliot; Kanji, Suman; Tomimatsu, Nozomi et al. · 2021 · Cancer research · DOI

Full title: Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence.

Authors: Fletcher-Sananikone, Eliot; Kanji, Suman; Tomimatsu, Nozomi; Di Cristofaro, Luis Fernando Macedo; Kollipara, Rahul K; Saha, Debabrata; Floyd, John R; Sung, Patrick; Hromas, Robert; Burns, Terry C; Kittler, Ralf; Habib, Amyn A; Mukherjee, Bipasha; Burma, Sandeep

Year: 2021

Venue: Cancer research

DOI: https://doi.org/10.1158/0008-5472.CAN-21-0752

Paper Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma.

Gleason, Caroline E; Dickson, Mark A; Klein Dooley, Mary E et al. · 2024 · Clinical cancer research : an official journal of the American Association for Cancer Research · DOI

Full title: Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma.

Authors: Gleason, Caroline E; Dickson, Mark A; Klein Dooley, Mary E; Antonescu, Cristina R; Gularte-Mérida, Rodrigo; Benitez, Marimar; Delgado, Juliana I; Kataru, Raghu P; Tan, Mark Wei Yi; Bradic, Martina; Adamson, Travis E; Seier, Kenneth; Richards, Allison L; Palafox, Marta; Chan, Eric; D'Angelo, Sandra P; Gounder, Mrinal M; Keohan, Mary Louise; Kelly, Ciara M; Chi, Ping; Movva, Sujana; Landa, Jonathan; Crago, Aimee M; Donoghue, Mark T A; Qin, Li-Xuan; Serra, Violetta; Turkekul, Mesruh; Barlas, Afsar; Firester, Daniel M; Manova-Todorova, Katia; Mehrara, Babak J; Kovatcheva, Marta; Tan, Nguan Soon; Singer, Samuel; Tap, William D; Koff, Andrew

Year: 2024

Venue: Clinical cancer research : an official journal of the American Association for Cancer Research

DOI: https://doi.org/10.1158/1078-0432.CCR-23-2378

Paper The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24−/− Progeria Mouse Model

W. S. Hambright; Xiaodong Mu; Xueqin Gao et al. · 2023 · Journal of Osteoporosis · DOI

Full title: The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24−/− Progeria Mouse Model

Authors: W. S. Hambright; Xiaodong Mu; Xueqin Gao; Ping Guo; Y. Kawakami; J. Mitchell; M. Mullen; A. Nelson; Chelsea S. Bahney; H. Nishimura; Justin E. Hellwinkel; Andrew Eck; J. Huard

Year: 2023

Venue: Journal of Osteoporosis

DOI: https://doi.org/10.1155/2023/5572754

Paper Extracellular Vesicle-Packaged ACSL4 Induces Hepatocyte Senescence to Promote Hepatocellular Carcinoma Progression.

Pei-Pei Hou; Chong-Ming Zheng; Si-Hong Wu et al. · 2024 · Cancer Research · DOI

Full title: Extracellular Vesicle-Packaged ACSL4 Induces Hepatocyte Senescence to Promote Hepatocellular Carcinoma Progression.

Authors: Pei-Pei Hou; Chong-Ming Zheng; Si-Hong Wu; Xi-Xiao Liu; Guangxin Xiang; Wei-Yang Cai; Gang Chen; Yongliang Lou

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/0008-5472.can-24-0832

Paper Cortactin Suppresses mTOR-Dependent Senescence in Circulating Tumor Cells.

Hu, Jianyang; Zhang, Binyu; Chen, Junhao et al. · 2025 · Cancer research · DOI

Full title: Cortactin Suppresses mTOR-Dependent Senescence in Circulating Tumor Cells.

Authors: Hu, Jianyang; Zhang, Binyu; Chen, Junhao; Huang, Guanyin; Zhao, Mao; Zhou, Hongchao; Yang, Fan; Liu, Ke; Zheng, Shuqian; Tan, Haoyuan; Liu, Xuefei; Liu, Jialing; Hu, Hailiang; Wang, Luhua; Zhang, Jianglin; Dai, Lingyun; Chen, Qingfeng; Pan, Xinghua; Li, Hongchang; Yu, Hao; Guo, Weinan; Hong, Xin

Year: 2025

Venue: Cancer research

DOI: https://doi.org/10.1158/0008-5472.CAN-25-1175

Paper The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

J. Buhl; J. Buhl; F. Selt et al. · 2018 · Clinical Cancer Research · DOI

Full title: The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

Authors: J. Buhl; J. Buhl; F. Selt; F. Selt; T. Hielscher; Romain Guiho; J. Ecker; J. Ecker; F. Sahm; F. Sahm; J. Ridinger; J. Ridinger; D. Riehl; D. Usta; B. Ismer; B. Ismer; A. Sommerkamp; A. Sommerkamp; J. Martínez-Barbera; A. Wefers; A. Wefers; M. Remke; M. Remke; Daniel Picard; Daniel Picard; S. Pusch; S. Pusch; J. Gronych; I. Oehme; C. M. Tilburg; C. M. Tilburg; M. Kool; Daniel Kuhn; David Capper; David Capper; David Capper; A. Deimling; A. Deimling; M. Schuhmann; C. Herold‐Mende; A. Korshunov; A. Korshunov; T. Brummer; Stefan M. Pfister; Stefan M. Pfister; David T. W. Jones; Olaf Witt; Olaf Witt; T. Milde; T. Milde

Year: 2018

Venue: Clinical Cancer Research

DOI: https://doi.org/10.1158/1078-0432.ccr-18-1965

Paper Single-cell Transcriptomic Analysis Identifies Senescent Osteocytes that Trigger Bone Destruction in Breast Cancer Metastasis.

Japneet Kaur; Manish Adhikari; H. Sabol et al. · 2024 · Cancer Research · DOI

Full title: Single-cell Transcriptomic Analysis Identifies Senescent Osteocytes that Trigger Bone Destruction in Breast Cancer Metastasis.

Authors: Japneet Kaur; Manish Adhikari; H. Sabol; A. Anloague; Sharmin Khan; Noriyoshi Kurihara; Marta Diaz-delCastillo; C. Andreasen; C. L. Barnes; J.B. Stambough; Michela Palmieri; Olivia Reyes-Castro; Jennifer Zarrer; H. Taipaleenmäki; E. Ambrogini; Maria Almeida; Charles O'Brien; I. Nookaew; J. Delgado-Calle

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/0008-5472.can-24-0857

Paper Abstract 2449: FGFR4 inhibitor BLU9931 induces cellular senescence in pancreatic ductal adenocarcinoma cell lines promoting sensitivity to senolytic therapy

Norihiko Sasaki; F. Gomi; H. Yoshimura et al. · 2021 · Molecular and Cellular Biology/Genetics · DOI

Full title: Abstract 2449: FGFR4 inhibitor BLU9931 induces cellular senescence in pancreatic ductal adenocarcinoma cell lines promoting sensitivity to senolytic therapy

Authors: Norihiko Sasaki; F. Gomi; H. Yoshimura; Masami Yamamoto; Y. Matsuda; M. Michishita; H. Hatakeyama; Y. Kawano; Yoko Itakura; M. Toyoda; M. Korc; T. Ishiwata

Year: 2021

Venue: Molecular and Cellular Biology/Genetics

DOI: https://doi.org/10.1158/1538-7445.am2021-2449

Paper Abstract 901: Elimination of senescent tumor cells by ABT263 interferes with proliferative recovery and provides a two-hit therapeutic approach

T. Saleh; Liliya Tyutyunyk‐Massey; Graeme F Murray et al. · 2019 · Molecular and Cellular Biology / Genetics · DOI

Full title: Abstract 901: Elimination of senescent tumor cells by ABT263 interferes with proliferative recovery and provides a two-hit therapeutic approach

Authors: T. Saleh; Liliya Tyutyunyk‐Massey; Graeme F Murray; M. Alotaibi; Ajinkya S Kawale; Zeinab Elsayed; S. Henderson; V. Yakovlev; L. Elmore; A. Toor; H. Harada; J. Reed; Joseph W. Landry; D. Gewirtz

Year: 2019

Venue: Molecular and Cellular Biology / Genetics

DOI: https://doi.org/10.1158/1538-7445.am2019-901

Paper Tales of Cancer-Induced Bone Disease from the Senescent Osteocyte Crypt.

Jeremy S. Frieling; Conor C Lynch · 2024 · Cancer Research · DOI

Full title: Tales of Cancer-Induced Bone Disease from the Senescent Osteocyte Crypt.

Authors: Jeremy S. Frieling; Conor C Lynch

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/0008-5472.can-24-3611

Paper Abstract B022: Targeting senescence cells in cancer and aging by conditionally active biologic therapeutics

Jian Chen; Jing Wang; Matt Lucas et al. · 2023 · Cancer Research · DOI

Full title: Abstract B022: Targeting senescence cells in cancer and aging by conditionally active biologic therapeutics

Authors: Jian Chen; Jing Wang; Matt Lucas; Haizhen Liu; C. Wheeler; Kyrie Johnson; Kathryn Woodard; Cathy Y. Chang; G. Frey; W. J. Boyle; J. Short

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.agca22-b022

Paper Harnessing senolytics and PARP inhibition to expand the antitumor activity of CDK4/6 inhibitors in prostate cancer.

Julian Brandariz; L. D. De Llobet; Victor Esquefa et al. · 2025 · Molecular Cancer Therapeutics · DOI

Full title: Harnessing senolytics and PARP inhibition to expand the antitumor activity of CDK4/6 inhibitors in prostate cancer.

Authors: Julian Brandariz; L. D. De Llobet; Victor Esquefa; Daniel Aguilar; Andrei Salca; Sara Arce-Gallego; Pablo Cresta Morgado; Arnau Sole Casaramona; Laura Agundez Muriel; Gisela Mir Arnau; Natalia Castro; Teresa Casals Galobart; Anna Oliveira Tercero; I. Casanova-Salas; Marcos Malumbres; Joan Carles; Ángela Morellá-Aucejo; A. Bernardos; R. Martínez‐Máñez; J. Mateo; Nicolas Herranz

Year: 2025

Venue: Molecular Cancer Therapeutics

DOI: https://doi.org/10.1158/1535-7163.mct-24-0903

Paper Abstract 425: Characterization of TKI-induced drug-tolerant persister cells from a patient-derived cell line

F. Brayé; F. Facchinetti; Helena Gerber et al. · 2023 · Cancer Research · DOI

Full title: Abstract 425: Characterization of TKI-induced drug-tolerant persister cells from a patient-derived cell line

Authors: F. Brayé; F. Facchinetti; Helena Gerber; Juliette Juigné; G. Guaitoli; J. Thiery; S. Ponce; B. Besse; K. Olaussen; L. Friboulet

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2023-425

Paper Abstract 5025: Single cell RNA sequencing reveals degenerative mechanisms in osteoblastic osteosarcoma and targetability of senescent subpopulations

D. Saul; R. L. Kosinsky · 2022 · Cancer Research · DOI

Full title: Abstract 5025: Single cell RNA sequencing reveals degenerative mechanisms in osteoblastic osteosarcoma and targetability of senescent subpopulations

Authors: D. Saul; R. L. Kosinsky

Year: 2022

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2022-5025

Paper Abstract 2958: Melphalan-treated multiple myeloma cells exhibit a senescent-like dormancy phenotype

A. Guilatco; Marta Diaz-del-Castillo; Gabriel Alvares Borges et al. · 2024 · Cancer Research · DOI

Full title: Abstract 2958: Melphalan-treated multiple myeloma cells exhibit a senescent-like dormancy phenotype

Authors: A. Guilatco; Marta Diaz-del-Castillo; Gabriel Alvares Borges; Neal I. Sannuli; M. Ritting; Syed Mohammed Musheer Aalam; Nagarajan Kannan; Tamar Tchkonia; James L. Kirkland; Yi Lin; T. Kourelis; Matthew T. Drake; T. Andersen; Megan M. Weivoda

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2024-2958

Paper Abstract 5941: Small molecule NSC59984 synergizes with PARP inhibitors in BRCA1 wild type ovarian cancer

Shengliang Zhang; Lanlan Zhou; Leiqing Zhang et al. · 2024 · Cancer Research · DOI

Full title: Abstract 5941: Small molecule NSC59984 synergizes with PARP inhibitors in BRCA1 wild type ovarian cancer

Authors: Shengliang Zhang; Lanlan Zhou; Leiqing Zhang; Maximilian Pinho-Schwermann; B. Carneiro; John Sedivy; W. El-Deiry

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2024-5941

Paper Abstract 2977: Novel HSP90 inhibitors with senolytic activity for a targeted therapy in a hormone-induced breast cancer senescence model

Luca Cis; Michela Gottardi Zamperla; V. Barbi et al. · 2024 · Cancer Research · DOI

Full title: Abstract 2977: Novel HSP90 inhibitors with senolytic activity for a targeted therapy in a hormone-induced breast cancer senescence model

Authors: Luca Cis; Michela Gottardi Zamperla; V. Barbi; Pietro Cigala Fulgosi; Sara De Martino; A. Aiello; S. Nanni; C. Cencioni; Davide Pirolli; P. T. de Fatis; G. Ivaldi; Marco Malavolta; Christian Steinkühler; M. C. De Rosa; A. Farsetti; S. Atlante; C. Gaetano

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2024-2977

Paper Abstract 4795: Conditionally active biologics eliminates senescence cells in cancer and aging

Jian Chen; C. Wheeler; Jing Wang et al. · 2023 · Cancer Research · DOI

Full title: Abstract 4795: Conditionally active biologics eliminates senescence cells in cancer and aging

Authors: Jian Chen; C. Wheeler; Jing Wang; Matt Lucas; Haizhen Liu; Kyrie Johnson; Kathryn Woodard; Solmarie Joyner; Cathy Y. Chang; W. J. Boyle; J. Short

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2023-4795

Paper Abstract 4796: Chemotherapy induced senescence drives peripheral neuropathy

Taylor Malachowski; G. Raut; Satarupa Mullick Bagchi et al. · 2023 · Cancer Research · DOI

Full title: Abstract 4796: Chemotherapy induced senescence drives peripheral neuropathy

Authors: Taylor Malachowski; G. Raut; Satarupa Mullick Bagchi; S. Stewart

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2023-4796

Paper Abstract 5221: The first-in-class ERK inhibitor ulixertinib (BVD-523) shows activity in MAPK-driven pediatric low-grade glioma models as single agent and in combination with MEK inhibitors or senolytics

Romain Sigaud; Lisa Rösch; Charlotte Gatzweiler et al. · 2022 · Cancer Research · DOI

Full title: Abstract 5221: The first-in-class ERK inhibitor ulixertinib (BVD-523) shows activity in MAPK-driven pediatric low-grade glioma models as single agent and in combination with MEK inhibitors or senolytics

Authors: Romain Sigaud; Lisa Rösch; Charlotte Gatzweiler; Julia Benzel; Laura von Soosten; H. Peterziel; S. Najafi; Simay Ayhan; Xena F Gerloff; Nina Hofmann; Isabel Büdenbender; K. Foerster; J. Burhenne; Rémi Longuespée; Cornelis M. van Tilburg; David C. Jones; S. Pfister; D. Knoerzer; B. Kreider; M. Sauter; K. Pajtler; Marc Zuckermann; I. Oehme; O. Witt; T. Milde

Year: 2022

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2022-5221

Paper Abstract CT095: Update: a phase 1/2, open-label study to assess safety, tolerability, biodistribution, radiation dosimetry and PET imaging characteristics of [18F]FPyGal in comparison to in-vitro diagnostic for the assessment of senescence in oncological patients (NCT04536454)

C. Lafougère; B. Gueckel; Helmut Dittmann et al. · 2023 · Cancer Research · DOI

Full title: Abstract CT095: Update: a phase 1/2, open-label study to assess safety, tolerability, biodistribution, radiation dosimetry and PET imaging characteristics of [18F]FPyGal in comparison to in-vitro diagnostic for the assessment of senescence in oncological patients (NCT04536454)

Authors: C. Lafougère; B. Gueckel; Helmut Dittmann; Nils F. Trautwein; Martina Hinterleitner; J. Cotton; G. Reischl; G. Kienzle; Stephan Singer; Cihan Gani; Ulrich M. Lauer; B. Pichler; L. Zender

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2023-ct095

Paper Abstract 519: CDK4/6 inhibitors and endocrine therapies induce senescence with drug- and cell line-specific vulnerabilities in ERα+ breast cancer

Lena Batoon; A. Guilatco; Anna Detry et al. · 2025 · Cancer Research · DOI

Full title: Abstract 519: CDK4/6 inhibitors and endocrine therapies induce senescence with drug- and cell line-specific vulnerabilities in ERα+ breast cancer

Authors: Lena Batoon; A. Guilatco; Anna Detry; Xiyin Wang; Megan M. Weivoda; John R. Hawse

Year: 2025

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2025-519

Paper Abstract PR001: DNA damage-induced senescence as a driver of glioblastoma recurrence

S. Burma; N. Tomimatsu; Luis Cristofaro et al. · 2024 · Cancer Research · DOI

Full title: Abstract PR001: DNA damage-induced senescence as a driver of glioblastoma recurrence

Authors: S. Burma; N. Tomimatsu; Luis Cristofaro; Suman Kanji; B. Jordan; Bipasha Mukherjee

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.dnarepair24-pr001

Paper Abstract SoA2-02: Implications of therapy induced senescence in breast cancer

J. Jackson · 2024 · Cancer Research · DOI

Full title: Abstract SoA2-02: Implications of therapy induced senescence in breast cancer

Authors: J. Jackson

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.sabcs23-soa2-02

Paper Abstract A028: Dissecting the role of cellular senescence in prostate cancer initiation and immune suppression

Lin Zhou; Jarin T. Snyder; Katherine C. Murphy et al. · 2023 · Cancer Research · DOI

Full title: Abstract A028: Dissecting the role of cellular senescence in prostate cancer initiation and immune suppression

Authors: Lin Zhou; Jarin T. Snyder; Katherine C. Murphy; Kelly D. DeMarco; Sachliv K. Chana; K. Simin; Zhong Jiang; M. Ruscetti

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.prca2023-a028

Paper Abstract 85: Senescent cells promote breast cancer tumorigenesis

Jiayu Ye; A. P. Delgado; Qihao Ren et al. · 2023 · Cancer Research · DOI

Full title: Abstract 85: Senescent cells promote breast cancer tumorigenesis

Authors: Jiayu Ye; A. P. Delgado; Qihao Ren; R. Powers; S. Stewart

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2023-85

Paper Abstract 299: Characterization of a senescence phenotype induced by advanced glycation end products in prostate cancer

Luisa Bacca; Tarek Hallal; Carole Luthold et al. · 2025 · Cancer Research · DOI

Full title: Abstract 299: Characterization of a senescence phenotype induced by advanced glycation end products in prostate cancer

Authors: Luisa Bacca; Tarek Hallal; Carole Luthold; N. Boufaied; François Bordeleau; David P. Labbé

Year: 2025

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2025-299

Paper Abstract 2962: Chemotherapy induced senescence drives peripheral neuropathy

Taylor Malachowski; G. Raut; Xianmin Luo et al. · 2024 · Cancer Research · DOI

Full title: Abstract 2962: Chemotherapy induced senescence drives peripheral neuropathy

Authors: Taylor Malachowski; G. Raut; Xianmin Luo; Satarupa Mullick Bagchi; Sheila A. Stewart

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2024-2962

Paper Abstract 296: Identification of novel senolytic targets and development of conditionally active biologic-based-drug conjugates for targeted senescence-associated secretory phenotype elimination in vivo

Jian Chen; Jing Wang; Haizhen Liu et al. · 2025 · Cancer Research · DOI

Full title: Abstract 296: Identification of novel senolytic targets and development of conditionally active biologic-based-drug conjugates for targeted senescence-associated secretory phenotype elimination in vivo

Authors: Jian Chen; Jing Wang; Haizhen Liu; G. Frey; Cathy Y. Chang; William J Boyle; Jay M Short

Year: 2025

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2025-296

Paper Targeting Senescence for Next-Generation Cancer Treatments

Gilson, Éric; Soubeyran, Pierre; Solary, Éric · 2024 · Cancer Discovery · DOI

Full title: Targeting Senescence for Next-Generation Cancer Treatments

Authors: Gilson, Éric; Soubeyran, Pierre; Solary, Éric

Year: 2024

Venue: Cancer Discovery

DOI: https://doi.org/10.1158/2159-8290.cd-24-0089

Paper Abstract A043: Senescent CAFs modulate tumor immunity and promote breast cancer progression

Jiayu Ye; John M Baer; Douglas V. Faget et al. · 2024 · Cancer Research · DOI

Full title: Abstract A043: Senescent CAFs modulate tumor immunity and promote breast cancer progression

Authors: Jiayu Ye; John M Baer; Douglas V. Faget; V. Morikis; Qihao Ren; Anupama Melam; Ana Paula Delgado; Erik S. Knudsen; A. Witkiewicz; Robert S. Powers; G. Longmore; D. DeNardo; Sheila A. Stewart

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.tumbody-a043

Paper Abstract 4726: ETC-501, a novel brain penetrant MNK kinase inhibitor, potentiates TMZ-induced senescence and sensitizes glioblastoma cells to senolytic therapy

G. Nah; Y. Chong; Fatin Nasha Sulaimi et al. · 2025 · Cancer Research · DOI

Full title: Abstract 4726: ETC-501, a novel brain penetrant MNK kinase inhibitor, potentiates TMZ-induced senescence and sensitizes glioblastoma cells to senolytic therapy

Authors: G. Nah; Y. Chong; Fatin Nasha Sulaimi; K. Lee; S. Lim; K. Nacro; Jeffrey Hill; Alex Matter; Henry Yang; B. Ang; Carol Tang; S. T. Ong

Year: 2025

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2025-4726

Paper Abstract Th0030: Impact of Atherosclerosis-Induced Cellular Senescence on Vascular Cognitive Impairment and Dementia

Charnae’ Henry-Smith; Dimitrios Tsitsipatis; K. Mazan-Mamczarz et al. · 2025 · Arteriosclerosis, Thrombosis and Vascular Biology · DOI

Full title: Abstract Th0030: Impact of Atherosclerosis-Induced Cellular Senescence on Vascular Cognitive Impairment and Dementia

Authors: Charnae’ Henry-Smith; Dimitrios Tsitsipatis; K. Mazan-Mamczarz; Ross McDevitt; N. Basisty; Nathan Price; Rafael de Cabo; Myriam Gorospe; Allison Herman

Year: 2025

Venue: Arteriosclerosis, Thrombosis and Vascular Biology

DOI: https://doi.org/10.1161/atv.45.suppl_1.th0030

Paper Abstract CT238: Treatment of frailty with fisetin (TROFFi) in postmenopausal breast cancer survivors: A phase II randomized double-blind placebo-controlled study

Jingran Ji; Marla D. Lipsyc-Sharf; Nikita V. Baclig et al. · 2025 · Cancer Research · DOI

Full title: Abstract CT238: Treatment of frailty with fisetin (TROFFi) in postmenopausal breast cancer survivors: A phase II randomized double-blind placebo-controlled study

Authors: Jingran Ji; Marla D. Lipsyc-Sharf; Nikita V. Baclig; Yulia A. Zektser; Ali Al Saleem; Joseph D. Olivera; Kelly S. Synold; Lauren R. Zelman; C. M. Crespi; Lisa D. Yee; Mina S. Sedrak

Year: 2025

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2025-ct238

Paper Adapted to Survive: Targeting Cancer Cells with BH3 Mimetics

Montero, Joan; Haq, Rizwan · 2022 · Cancer Discovery · DOI

Full title: Adapted to Survive: Targeting Cancer Cells with BH3 Mimetics

Authors: Montero, Joan; Haq, Rizwan

Year: 2022

Venue: Cancer Discovery

DOI: https://doi.org/10.1158/2159-8290.cd-21-1334

Paper Senolytics Cocktail Dasatinib and Quercetin Alleviate Human Umbilical Vein Endothelial Cell Senescence via the TRAF6-MAPK-NF-κB Axis in a YTHDF2-Dependent Manner

Ting-ting Fan; Yi-ting Du; Mingwan Zhang et al. · 2022 · Gerontology · DOI

Full title: Senolytics Cocktail Dasatinib and Quercetin Alleviate Human Umbilical Vein Endothelial Cell Senescence via the TRAF6-MAPK-NF-κB Axis in a YTHDF2-Dependent Manner

Authors: Ting-ting Fan; Yi-ting Du; Mingwan Zhang; Austin Rui Zhu; Jianjun Zhang

Year: 2022

Venue: Gerontology

DOI: https://doi.org/10.1159/000522656

Paper P21-positive senescent stromal cells promote prostate cancer immune suppression and progression that can be reversed by senolytic therapy.

Lin Zhou; Kelly D. DeMarco; Katherine C. Murphy et al. · 2025 · Cancer Discovery · DOI

Full title: P21-positive senescent stromal cells promote prostate cancer immune suppression and progression that can be reversed by senolytic therapy.

Authors: Lin Zhou; Kelly D. DeMarco; Katherine C. Murphy; Zhenpeng Wu; Jinping Li; Calvin Johnson; Bin Liu; Hadiya K. Giwa; Boyang Ma; Nikita Bhalerao; Junhui Li; Zhong Jiang; Shi Bai; Chaitanya N. Parikh; Tianyi Ye; Karl Simin; L. J. Zhu; Jason R. Pitarresi; Hong Wu; M. Ruscetti

Year: 2025

Venue: Cancer Discovery

DOI: https://doi.org/10.1158/2159-8290.cd-25-1212

Paper Abstract 2969: Targeting novel senescence markers by conditionally active biologics eliminates senescence-associated secretory phenotype in in vitro and in vivo models

Jian Chen; Jian Wang; Haizhen Liu et al. · 2024 · Cancer Research · DOI

Full title: Abstract 2969: Targeting novel senescence markers by conditionally active biologics eliminates senescence-associated secretory phenotype in in vitro and in vivo models

Authors: Jian Chen; Jian Wang; Haizhen Liu; Cathy Y. Chang; William J Boyle; Jay M Short

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2024-2969

Paper Abstract 13736: Elimination of Senescent Cells Targeting Senescence Associated Glycoprotein (sagp) Improved the Atherosclerosis and Diabetes

M. Suda; I. Shimizu; G. Katsuumi et al. · 2020 · Circulation · DOI

Full title: Abstract 13736: Elimination of Senescent Cells Targeting Senescence Associated Glycoprotein (sagp) Improved the Atherosclerosis and Diabetes

Authors: M. Suda; I. Shimizu; G. Katsuumi; Y. Yoshida; Y. Hayashi; T. Minamino

Year: 2020

Venue: Circulation

DOI: https://doi.org/10.1161/circ.142.suppl_3.13736

Paper Abstract 100: Omics Strategies To Identify Senescent Cells Mediating Extracellular Matrix Remodeling During Vascular Disease

Allison Herman; K. Mazan-Mamczarz; Dimitrios Tsitsipatis et al. · 2024 · Arteriosclerosis, Thrombosis and Vascular Biology · DOI

Full title: Abstract 100: Omics Strategies To Identify Senescent Cells Mediating Extracellular Matrix Remodeling During Vascular Disease

Authors: Allison Herman; K. Mazan-Mamczarz; Dimitrios Tsitsipatis; Bennett G. Childs; Darren J Baker; Carla Rocha Dos Santos; Olga V Fedorova; Myriam Gorospe

Year: 2024

Venue: Arteriosclerosis, Thrombosis and Vascular Biology

DOI: https://doi.org/10.1161/atvb.44.suppl_1.100

Paper Decoding senescent drivers in Alzheimer's disease: From bench to bedside.

Zhou, Runjin; Lin, Xiaoling; Liao, Zhenge et al. · 2026 · Ageing research reviews · DOI

Full title: Decoding senescent drivers in Alzheimer's disease: From bench to bedside.

Authors: Zhou, Runjin; Lin, Xiaoling; Liao, Zhenge; Lin, Jian; Zheng, Ruixue; Ni, Haojie; Liu, Wei; Feng, Zhanpeng; He, Qiuxing; Lin, Xingdong; Tang, Chunzhi; Song, Juxian; Ning, Weimin

Year: 2026

Venue: Ageing research reviews

DOI: https://doi.org/10.1016/j.arr.2025.102978

Paper p53 regulated senescence mechanism and role of its modulators in age-related disorders.

Pawge, Girija; Khatik, Gopal L · 2021 · Biochemical pharmacology · DOI

Full title: p53 regulated senescence mechanism and role of its modulators in age-related disorders.

Authors: Pawge, Girija; Khatik, Gopal L

Year: 2021

Venue: Biochemical pharmacology

DOI: https://doi.org/10.1016/j.bcp.2021.114651

Paper The aging interactome: From cellular dysregulation to therapeutic frontiers in age-related diseases.

Abo Qoura, Louay; Churov, Alexey V; Maltseva, Olga N et al. · 2026 · Biochimica et biophysica acta. Molecular basis of disease · DOI

Full title: The aging interactome: From cellular dysregulation to therapeutic frontiers in age-related diseases.

Authors: Abo Qoura, Louay; Churov, Alexey V; Maltseva, Olga N; Arbatskiy, Mikhail S; Tkacheva, Olga N

Year: 2026

Venue: Biochimica et biophysica acta. Molecular basis of disease

DOI: https://doi.org/10.1016/j.bbadis.2025.168060

Paper Targeting senescent HDF with the USP7 inhibitor P5091 to enhance DFU wound healing through the p53 pathway.

Zhang, Siyu; Meng, Na; Liu, Shuhua et al. · 2024 · Biochemical and biophysical research communications · DOI

Full title: Targeting senescent HDF with the USP7 inhibitor P5091 to enhance DFU wound healing through the p53 pathway.

Authors: Zhang, Siyu; Meng, Na; Liu, Shuhua; Ruan, Jingjing; Li, Hongju; Xu, Ximing; Ruan, Qiongfang; Xie, Weiguo

Year: 2024

Venue: Biochemical and biophysical research communications

DOI: https://doi.org/10.1016/j.bbrc.2024.150149

Paper Senolytic therapeutics: An emerging treatment modality for osteoarthritis.

Ansari, Md Meraj; Ghosh, Mrinmoy; Lee, Dong-Sun et al. · 2024 · Ageing research reviews · DOI

Full title: Senolytic therapeutics: An emerging treatment modality for osteoarthritis.

Authors: Ansari, Md Meraj; Ghosh, Mrinmoy; Lee, Dong-Sun; Son, Young-Ok

Year: 2024

Venue: Ageing research reviews

DOI: https://doi.org/10.1016/j.arr.2024.102275

Paper Inhibition of matrix metalloproteinase expression by selective clearing of senescent dermal fibroblasts attenuates ultraviolet-induced photoaging.

Kim, Haesoo; Jang, Jeehee; Song, Min Ji et al. · 2022 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · DOI

Full title: Inhibition of matrix metalloproteinase expression by selective clearing of senescent dermal fibroblasts attenuates ultraviolet-induced photoaging.

Authors: Kim, Haesoo; Jang, Jeehee; Song, Min Ji; Park, Chi-Hyun; Lee, Dong Hun; Lee, Si-Hyung; Chung, Jin Ho

Year: 2022

Venue: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

DOI: https://doi.org/10.1016/j.biopha.2022.113034

Paper Pursuing healthy aging and longevity through natural product and stem cell-driven rejuvenation.

Wu, Di; Xu, Qinzheng; Wu, Shuang et al. · 2025 · Biochemical pharmacology · DOI

Full title: Pursuing healthy aging and longevity through natural product and stem cell-driven rejuvenation.

Authors: Wu, Di; Xu, Qinzheng; Wu, Shuang; Tan, Jiachen; Khan, Faheem Ahmed; Pandupuspitasari, Nuruliarizki Shinta; Huang, Chunjie

Year: 2025

Venue: Biochemical pharmacology

DOI: https://doi.org/10.1016/j.bcp.2025.117359

Paper Frentizole derivatives with mTOR inhibiting and senomorphic properties.

Chrienova, Zofia; Rysanek, David; Novak, Josef et al. · 2023 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · DOI

Full title: Frentizole derivatives with mTOR inhibiting and senomorphic properties.

Authors: Chrienova, Zofia; Rysanek, David; Novak, Josef; Vasicova, Pavla; Oleksak, Patrik; Andrys, Rudolf; Skarka, Adam; Dumanovic, Jelena; Milovanovic, Zoran; Jacevic, Vesna; Chvojkova, Marketa; Holubova, Kristina; Vales, Karel; Skoupilova, Veronika; Valko, Marian; Jomova, Klaudia; Alomar, Suliman Y; Botelho, Fernanda D; Franca, Tanos C C; Kuca, Kamil; Hodny, Zdenek; Nepovimova, Eugenie

Year: 2023

Venue: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

DOI: https://doi.org/10.1016/j.biopha.2023.115600

Paper Immunosenescence and macrophages: from basics to therapeutics.

Hongkang Zhu; Fanglin Shen; Tingting Liao et al. · 2023 · International Journal of Biochemistry and Cell Biology · DOI

Full title: Immunosenescence and macrophages: from basics to therapeutics.

Authors: Hongkang Zhu; Fanglin Shen; Tingting Liao; He Qian; Yu Liu

Year: 2023

Venue: International Journal of Biochemistry and Cell Biology

DOI: https://doi.org/10.1016/j.biocel.2023.106479

Paper Androgen-deprivation induced senescence in prostate cancer cells is permissive for the development of castration-resistance but susceptible to senolytic therapy.

Carpenter, Valerie; Saleh, Tareq; Min Lee, So et al. · 2021 · Biochemical pharmacology · DOI

Full title: Androgen-deprivation induced senescence in prostate cancer cells is permissive for the development of castration-resistance but susceptible to senolytic therapy.

Authors: Carpenter, Valerie; Saleh, Tareq; Min Lee, So; Murray, Graeme; Reed, Jason; Souers, Andrew; Faber, Anthony C; Harada, Hisashi; Gewirtz, David A

Year: 2021

Venue: Biochemical pharmacology

DOI: https://doi.org/10.1016/j.bcp.2021.114765

Paper Senescence and castration resistance in prostate cancer: A review of experimental evidence and clinical implications.

Carpenter, Valerie J; Patel, Bhaumik B; Autorino, Riccardo et al. · 2020 · Biochimica et biophysica acta. Reviews on cancer · DOI

Full title: Senescence and castration resistance in prostate cancer: A review of experimental evidence and clinical implications.

Authors: Carpenter, Valerie J; Patel, Bhaumik B; Autorino, Riccardo; Smith, Steven C; Gewirtz, David A; Saleh, Tareq

Year: 2020

Venue: Biochimica et biophysica acta. Reviews on cancer

DOI: https://doi.org/10.1016/j.bbcan.2020.188424

Paper Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6.

Wang, Xuezhong; Li, Xuyang; Zhou, Jianlin et al. · 2024 · Chemico-biological interactions · DOI

Full title: Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6.

Authors: Wang, Xuezhong; Li, Xuyang; Zhou, Jianlin; Lei, Zheng; Yang, Xiaoming

Year: 2024

Venue: Chemico-biological interactions

DOI: https://doi.org/10.1016/j.cbi.2024.110890

Paper Decoding craniopharyngioma: From mechanisms to therapy.

Gonzalez-Meljem, Jose Mario; Cao, Lei; Apps, John Richard et al. · 2025 · Best practice & research. Clinical endocrinology & metabolism · DOI

Full title: Decoding craniopharyngioma: From mechanisms to therapy.

Authors: Gonzalez-Meljem, Jose Mario; Cao, Lei; Apps, John Richard; Martinez-Barbera, Juan Pedro

Year: 2025

Venue: Best practice & research. Clinical endocrinology & metabolism

DOI: https://doi.org/10.1016/j.beem.2025.102051

Paper Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis.

Guccini, Ilaria; Revandkar, Ajinkya; D'Ambrosio, Mariantonietta et al. · 2021 · Cancer cell · DOI

Full title: Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis.

Authors: Guccini, Ilaria; Revandkar, Ajinkya; D'Ambrosio, Mariantonietta; Colucci, Manuel; Pasquini, Emiliano; Mosole, Simone; Troiani, Martina; Brina, Daniela; Sheibani-Tezerji, Raheleh; Elia, Angela Rita; Rinaldi, Andrea; Pernigoni, Nicolò; Rüschoff, Jan Hendrik; Dettwiler, Susanne; De Marzo, Angelo M; Antonarakis, Emmanuel S; Borrelli, Costanza; Moor, Andreas E; Garcia-Escudero, Ramon; Alajati, Abdullah; Attanasio, Giuseppe; Losa, Marco; Moch, Holger; Wild, Peter; Egger, Gerda; Alimonti, Andrea

Year: 2021

Venue: Cancer cell

DOI: https://doi.org/10.1016/j.ccell.2020.10.012

Paper Role of astrocyte senescence regulated by the non- canonical autophagy in the neuroinflammation associated to cerebral malaria.

Hellani, Fatima; Leleu, Inès; Saidi, Nasreddine et al. · 2024 · Brain, behavior, and immunity · DOI

Full title: Role of astrocyte senescence regulated by the non- canonical autophagy in the neuroinflammation associated to cerebral malaria.

Authors: Hellani, Fatima; Leleu, Inès; Saidi, Nasreddine; Martin, Nathalie; Lecoeur, Cécile; Werkmeister, Elisabeth; Koffi, David; Trottein, François; Yapo-Etté, Hélène; Das, Bidyut; Abbadie, Corinne; Pied, Sylviane

Year: 2024

Venue: Brain, behavior, and immunity

DOI: https://doi.org/10.1016/j.bbi.2023.12.030

Paper Implication of cellular senescence in the progression of chronic kidney disease and the treatment potencies.

Wang, Yao; Wang, Ying; Yang, Ming et al. · 2021 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · DOI

Full title: Implication of cellular senescence in the progression of chronic kidney disease and the treatment potencies.

Authors: Wang, Yao; Wang, Ying; Yang, Ming; Ma, Xingjie

Year: 2021

Venue: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

DOI: https://doi.org/10.1016/j.biopha.2020.111191

Paper Cellular senescence in bone.

J. Farr; S. Khosla · 2019 · Bone · DOI

Full title: Cellular senescence in bone.

Authors: J. Farr; S. Khosla

Year: 2019

Venue: Bone

DOI: https://doi.org/10.1016/j.bone.2019.01.015

Paper Advances in targeted therapies for age-related osteoarthritis: A comprehensive review of current research.

Zhang, Yantao; Zhou, Yan · 2024 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · DOI

Full title: Advances in targeted therapies for age-related osteoarthritis: A comprehensive review of current research.

Authors: Zhang, Yantao; Zhou, Yan

Year: 2024

Venue: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

DOI: https://doi.org/10.1016/j.biopha.2024.117314

Paper The anti-aging drug Senolytics alleviates vascular endothelial cell senescence by antagonizing the JPX-BRD4-p65 complex.

Mao, Kaili; Zhu, Wensi; Sun, Huayu et al. · 2026 · Cellular signalling · DOI

Full title: The anti-aging drug Senolytics alleviates vascular endothelial cell senescence by antagonizing the JPX-BRD4-p65 complex.

Authors: Mao, Kaili; Zhu, Wensi; Sun, Huayu; Zheng, Hongliang; Fu, Zhenling

Year: 2026

Venue: Cellular signalling

DOI: https://doi.org/10.1016/j.cellsig.2025.112342

Paper 3-N-Butylphthalide alleviate Aβ-induced cellular senescence through the CDK2-pRB1-Caspase3 axis.

Tian, Yuanruhua; Li, Wenke; Zhang, Yongbo · 2025 · Brain research · DOI

Full title: 3-N-Butylphthalide alleviate Aβ-induced cellular senescence through the CDK2-pRB1-Caspase3 axis.

Authors: Tian, Yuanruhua; Li, Wenke; Zhang, Yongbo

Year: 2025

Venue: Brain research

DOI: https://doi.org/10.1016/j.brainres.2024.149435

Paper Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer.

S. Haston; Estela González-Gualda; Samir Morsli et al. · 2023 · Cancer Cell · DOI

Full title: Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer.

Authors: S. Haston; Estela González-Gualda; Samir Morsli; Jianfeng Ge; Virinder Reen; Alexander Calderwood; Ilias Moutsopoulos; L. Panousopoulos; Polina Deletic; G. Carreno; Romain Guiho; S. Manshaei; J. M. González-Meljem; Hui Yuan Lim; Daniel J. Simpson; J. Birch; Husayn Pallikonda; T. Chandra; David Macías; G. Doherty; D. Rassl; R. Rintoul; M. Signore; I. Mohorianu; A. Akbar; Jesús Gil; D. Muñoz‐Espín; J. Martínez-Barbera

Year: 2023

Venue: Cancer Cell

DOI: https://doi.org/10.1016/j.ccell.2023.05.004

Paper Senotherapy: A New Horizon for COPD Therapy.

Baker, Jonathan R; Donnelly, Louise E; Barnes, Peter J · 2020 · Chest · DOI

Full title: Senotherapy: A New Horizon for COPD Therapy.

Authors: Baker, Jonathan R; Donnelly, Louise E; Barnes, Peter J

Year: 2020

Venue: Chest

DOI: https://doi.org/10.1016/j.chest.2020.01.027

Paper Targeting senescent cells improves functional recovery after spinal cord injury

Paramos-de-Carvalho, Diogo; Martins, Isaura; Cristóvão, Ana Margarida et al. · 2021 · Cell Reports · DOI

Full title: Targeting senescent cells improves functional recovery after spinal cord injury

Authors: Paramos-de-Carvalho, Diogo; Martins, Isaura; Cristóvão, Ana Margarida; Dias, Ana F.; Neves-Silva, Dalila; Pereira, Telmo; Chapela, Diana; Farinho, Ana; Jacinto, António; Saúde, Leonor

Year: 2021

Venue: Cell Reports

DOI: https://doi.org/10.1016/j.celrep.2021.109334

Paper Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease.

Chinta, Shankar J; Woods, Georgia; Demaria, Marco et al. · 2018 · Cell reports · DOI

Full title: Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease.

Authors: Chinta, Shankar J; Woods, Georgia; Demaria, Marco; Rane, Anand; Zou, Ying; McQuade, Amanda; Rajagopalan, Subramanian; Limbad, Chandani; Madden, David T; Campisi, Judith; Andersen, Julie K

Year: 2018

Venue: Cell reports

DOI: https://doi.org/10.1016/j.celrep.2017.12.092

Paper Early Vascular Ageing and Cellular Senescence in Chronic Kidney Disease

Dai, Lu; Qureshi, Abdul Rashid; Witasp, Anna et al. · 2019 · Computational and Structural Biotechnology Journal · DOI

Full title: Early Vascular Ageing and Cellular Senescence in Chronic Kidney Disease

Authors: Dai, Lu; Qureshi, Abdul Rashid; Witasp, Anna; Lindholm, Bengt; Stenvinkel, Peter

Year: 2019

Venue: Computational and Structural Biotechnology Journal

DOI: https://doi.org/10.1016/j.csbj.2019.06.015

Paper Human trials exploring anti-aging medicines.

Leonard Guarente; David A. Sinclair; Guido Kroemer · 2023 · Cell Metabolism · DOI

Full title: Human trials exploring anti-aging medicines.

Authors: Leonard Guarente; David A. Sinclair; Guido Kroemer

Year: 2023

Venue: Cell Metabolism

DOI: https://doi.org/10.1016/j.cmet.2023.12.007

Paper Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

L. Hickson; Larissa G P Langhi Prata; Shane A. Bobart et al. · 2019 · EBioMedicine · DOI

Full title: Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Authors: L. Hickson; Larissa G P Langhi Prata; Shane A. Bobart; Tamara K. Evans; N. Giorgadze; Shahrukh K Hashmi; S. Herrmann; M. Jensen; Qingyi Jia; Kyra L. Jordan; T. Kellogg; S. Khosla; D. Koerber; A. Lagnado; Donna K. Lawson; N. LeBrasseur; L. Lerman; Kathleen M. McDonald; T. Mckenzie; J. Passos; R. Pignolo; T. Pirtskhalava; Ishran M Saadiq; Kalli Schaefer; S. Textor; Stella G. Victorelli; Tammie L. Volkman; A. Xue; M. Wentworth; Erin O. Wissler Gerdes; Yi Zhu; T. Tchkonia; J. Kirkland

Year: 2019

Venue: EBioMedicine

DOI: https://doi.org/10.1016/j.ebiom.2019.08.069

Paper Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy.

Nogueira-Recalde, Uxía; Lorenzo-Gómez, Irene; Blanco, Francisco J et al. · 2019 · EBioMedicine · DOI

Full title: Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy.

Authors: Nogueira-Recalde, Uxía; Lorenzo-Gómez, Irene; Blanco, Francisco J; Loza, María I; Grassi, Diego; Shirinsky, Valery; Shirinsky, Ivan; Lotz, Martin; Robbins, Paul D; Domínguez, Eduardo; Caramés, Beatriz

Year: 2019

Venue: EBioMedicine

DOI: https://doi.org/10.1016/j.ebiom.2019.06.049

Paper Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.

Justice, Jamie N; Nambiar, Anoop M; Tchkonia, Tamar et al. · 2019 · EBioMedicine · DOI

Full title: Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.

Authors: Justice, Jamie N; Nambiar, Anoop M; Tchkonia, Tamar; LeBrasseur, Nathan K; Pascual, Rodolfo; Hashmi, Shahrukh K; Prata, Larissa; Masternak, Michal M; Kritchevsky, Stephen B; Musi, Nicolas; Kirkland, James L

Year: 2019

Venue: EBioMedicine

DOI: https://doi.org/10.1016/j.ebiom.2018.12.052

Paper Cellular Senescence: A Translational Perspective

J. Kirkland; T. Tchkonia · 2017 · EBioMedicine · DOI

Full title: Cellular Senescence: A Translational Perspective

Authors: J. Kirkland; T. Tchkonia

Year: 2017

Venue: EBioMedicine

DOI: https://doi.org/10.1016/j.ebiom.2017.04.013

Paper G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence

Santos‐Otte, Paula; Leysen, Hanne; Gastel, Jaana van et al. · 2019 · Computational and Structural Biotechnology Journal · DOI

Full title: G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence

Authors: Santos‐Otte, Paula; Leysen, Hanne; Gastel, Jaana van; Hendrickx, Jhana O.; Martin, Bronwen; Maudsley, Stuart

Year: 2019

Venue: Computational and Structural Biotechnology Journal

DOI: https://doi.org/10.1016/j.csbj.2019.08.005

Paper Cellular senescence in asthma: from pathogenesis to therapeutic challenges.

Wan, Rongjun; Srikaram, Prakhyath; Guntupalli, Vineeta et al. · 2023 · EBioMedicine · DOI

Full title: Cellular senescence in asthma: from pathogenesis to therapeutic challenges.

Authors: Wan, Rongjun; Srikaram, Prakhyath; Guntupalli, Vineeta; Hu, Chengping; Chen, Qiong; Gao, Peisong

Year: 2023

Venue: EBioMedicine

DOI: https://doi.org/10.1016/j.ebiom.2023.104717

Paper Role of Bcl-2 family anti-apoptosis inhibition in overcoming therapeutic resistance in prostate cancer: A systematic review.

Jaya, Indra; Safriadi, Ferry; Wijaya, Indra et al. · 2025 · Critical reviews in oncology/hematology · DOI

Full title: Role of Bcl-2 family anti-apoptosis inhibition in overcoming therapeutic resistance in prostate cancer: A systematic review.

Authors: Jaya, Indra; Safriadi, Ferry; Wijaya, Indra; Pitaloka, Pritha; Afifah, Ervi; Medina, Faiza Shifa; Bashari, Muhammad Hasan

Year: 2025

Venue: Critical reviews in oncology/hematology

DOI: https://doi.org/10.1016/j.critrevonc.2025.104895

Paper Reshaping of the tumor microenvironment by cellular senescence: An opportunity for senotherapies.

M. d’Ambrosio; Jesús Gil · 2023 · Developmental Cell · DOI

Full title: Reshaping of the tumor microenvironment by cellular senescence: An opportunity for senotherapies.

Authors: M. d’Ambrosio; Jesús Gil

Year: 2023

Venue: Developmental Cell

DOI: https://doi.org/10.1016/j.devcel.2023.05.010

Paper Epigenetic and senescence markers indicate an accelerated ageing-like state in women with preeclamptic pregnancies.

Suvakov, Sonja; Ghamrawi, Ranine; Cubro, Hajrunisa et al. · 2021 · EBioMedicine · DOI

Full title: Epigenetic and senescence markers indicate an accelerated ageing-like state in women with preeclamptic pregnancies.

Authors: Suvakov, Sonja; Ghamrawi, Ranine; Cubro, Hajrunisa; Tu, Haitao; White, Wendy M; Tobah, Yvonne S Butler; Milic, Natasa M; Grande, Joseph P; Cunningham, Julie M; Chebib, Fouad T; Prata, Larissa G P Langhi; Zhu, Yi; Tchkonia, Tamara; Kirkland, James L; Nath, Karl A; Milosavljevic, Aleksandar; Garovic, Vesna D

Year: 2021

Venue: EBioMedicine

DOI: https://doi.org/10.1016/j.ebiom.2021.103536

Paper The role of the senescence-associated secretory phenotype in cardiovascular disease among the elderly.

H. Sutanto; D. Fetarayani; M. R. Narendra et al. · 2025 · European journal of internal medicine · DOI

Full title: The role of the senescence-associated secretory phenotype in cardiovascular disease among the elderly.

Authors: H. Sutanto; D. Fetarayani; M. R. Narendra; Sally Aman Nasution

Year: 2025

Venue: European journal of internal medicine

DOI: https://doi.org/10.1016/j.ejim.2025.106488

Paper Natural senotherapeutics in respiratory health: Addressing cellular senescence, inflammaging, and immunosenescence in the aging lung.

Juan, M Emília; Verdaguer, Ester; Prohens, Rafel et al. · 2026 · European journal of pharmacology · DOI

Full title: Natural senotherapeutics in respiratory health: Addressing cellular senescence, inflammaging, and immunosenescence in the aging lung.

Authors: Juan, M Emília; Verdaguer, Ester; Prohens, Rafel; Ettcheto, Miren; Auladell, Carme; Camins, Antoni; Olloquequi, Jordi

Year: 2026

Venue: European journal of pharmacology

DOI: https://doi.org/10.1016/j.ejphar.2026.178620

Paper Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells.

Le, Hillary H; Cinaroglu, Suleyman S; Manalo, Elise C et al. · 2021 · EBioMedicine · DOI

Full title: Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells.

Authors: Le, Hillary H; Cinaroglu, Suleyman S; Manalo, Elise C; Ors, Aysegul; Gomes, Michelle M; Duan Sahbaz, Burcin; Bonic, Karla; Origel Marmolejo, Carlos A; Quentel, Arnaud; Plaut, Justin S; Kawashima, Taryn E; Ozdemir, E Sila; Malhotra, Sanjay V; Ahiska, Yavuz; Sezerman, Ugur; Bayram Akcapinar, Gunseli; Saldivar, Joshua C; Timucin, Emel; Fischer, Jared M

Year: 2021

Venue: EBioMedicine

DOI: https://doi.org/10.1016/j.ebiom.2021.103646

Paper Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability.

Nambiar, Anoop; Kellogg, Dean; Justice, Jaime et al. · 2023 · EBioMedicine · DOI

Full title: Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability.

Authors: Nambiar, Anoop; Kellogg, Dean; Justice, Jaime; Goros, Martin; Gelfond, Jonathan; Pascual, Rodolfo; Hashmi, Shahrukh; Masternak, Michal; Prata, Larissa; LeBrasseur, Nathan; Limper, Andrew; Kritchevsky, Stephen; Musi, Nicolas; Tchkonia, Tamara; Kirkland, James

Year: 2023

Venue: EBioMedicine

DOI: https://doi.org/10.1016/j.ebiom.2023.104481

Paper Identification of miR-106b-5p as a senolytic miRNA.

Zhang, Tianpeng; Nunes, Allancer; O'Kelly, Ryan et al. · 2025 · EBioMedicine · DOI

Full title: Identification of miR-106b-5p as a senolytic miRNA.

Authors: Zhang, Tianpeng; Nunes, Allancer; O'Kelly, Ryan; Angelini, Luise; Masternak, Michal M; Suh, Yousin; Dong, Xiao; Niedernhofer, Laura J; Robbins, Paul D

Year: 2025

Venue: EBioMedicine

DOI: https://doi.org/10.1016/j.ebiom.2025.105810

Paper Inhibitor PF-04691502 works as a senolytic to regulate cellular senescence.

Fan, Ziqiang; Tong, Yingdong; Yang, Ziyue et al. · 2024 · Experimental gerontology · DOI

Full title: Inhibitor PF-04691502 works as a senolytic to regulate cellular senescence.

Authors: Fan, Ziqiang; Tong, Yingdong; Yang, Ziyue; Wang, Shuai; Huang, Tiantian; Yang, Deying; Ni, Qingyong; Zhang, Mingwang; Li, Diyan; Yang, Mingyao; Fan, Xiaolan

Year: 2024

Venue: Experimental gerontology

DOI: https://doi.org/10.1016/j.exger.2024.112359

Paper Mechanisms of RPE senescence and potential role of αB crystallin peptide as a senolytic agent in experimental AMD.

Sreekumar, Parameswaran G; Reddy, Srinivasa T; Hinton, David R et al. · 2022 · Experimental eye research · DOI

Full title: Mechanisms of RPE senescence and potential role of αB crystallin peptide as a senolytic agent in experimental AMD.

Authors: Sreekumar, Parameswaran G; Reddy, Srinivasa T; Hinton, David R; Kannan, Ram

Year: 2022

Venue: Experimental eye research

DOI: https://doi.org/10.1016/j.exer.2021.108918

Paper Clinical strategies and animal models for developing senolytic agents.

Kirkland, James L; Tchkonia, Tamara · 2015 · Experimental gerontology · DOI

Full title: Clinical strategies and animal models for developing senolytic agents.

Authors: Kirkland, James L; Tchkonia, Tamara

Year: 2015

Venue: Experimental gerontology

DOI: https://doi.org/10.1016/j.exger.2014.10.012

Paper Procyanidin C1 from hawthorn modulates metabolic-inflammatory axis to combat vascular senescence in atherosclerosis.

Li, Min; Si, Jia-Yao; Xie, Peng-Fei et al. · 2026 · Food research international (Ottawa, Ont.) · DOI

Full title: Procyanidin C1 from hawthorn modulates metabolic-inflammatory axis to combat vascular senescence in atherosclerosis.

Authors: Li, Min; Si, Jia-Yao; Xie, Peng-Fei; Feng, Zhen-Jie; Li, Sheng-Jie; Zhou, Feng; Li, Jian-Mei

Year: 2026

Venue: Food research international (Ottawa, Ont.)

DOI: https://doi.org/10.1016/j.foodres.2025.118224

Paper Systems-level modelling of DNA damage, senescence, and stem cell dynamics in ageing.

Che, Anchen; Morgan, Amy E; Mc Auley, Mark T · 2026 · Experimental gerontology · DOI

Full title: Systems-level modelling of DNA damage, senescence, and stem cell dynamics in ageing.

Authors: Che, Anchen; Morgan, Amy E; Mc Auley, Mark T

Year: 2026

Venue: Experimental gerontology

DOI: https://doi.org/10.1016/j.exger.2026.113063

Paper Navitoclax safety, tolerability, and effect on biomarkers of senescence and neurodegeneration in aged nonhuman primates

Edward F. Greenberg; Martin J. Voorbach; Alexandra Smith et al. · 2024 · Heliyon · DOI

Full title: Navitoclax safety, tolerability, and effect on biomarkers of senescence and neurodegeneration in aged nonhuman primates

Authors: Edward F. Greenberg; Martin J. Voorbach; Alexandra Smith; David R. Reuter; Yuchuan Zhuang; Ji-Quan Wang; Dustin W. Wooten; Elizabeth M. Asque; Min Hu; C. Hoft; Ryan Duggan; Matthew Townsend; Karin Orsi; Karen Dalecki; Willi Amberg; Lori Duggan; Heather Knight; Joseph S. Spina; Yupeng He; Kennan C Marsh; Vivian Zhao; Suzanne Ybarra; J. Mollon; Yuni Fang; A. Vasanthakumar; Susan V Westmoreland; Mathias Droescher; S. Finnema; Hana Florian

Year: 2024

Venue: Heliyon

DOI: https://doi.org/10.1016/j.heliyon.2024.e36483

Paper Sphingomyelin nanosystems decorated with TSP-1 derived peptide targeting senescent cells.

Jatal, Raneem; Mendes Saraiva, Sofia; Vázquez-Vázquez, Carlos et al. · 2022 · International journal of pharmaceutics · DOI

Full title: Sphingomyelin nanosystems decorated with TSP-1 derived peptide targeting senescent cells.

Authors: Jatal, Raneem; Mendes Saraiva, Sofia; Vázquez-Vázquez, Carlos; Lelievre, Eric; Coqueret, Olivier; López-López, Rafael; de la Fuente, María

Year: 2022

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2022.121618

Paper Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging.

Zhou, Zhao; Yao, Jingfei; Wu, Dongmei et al. · 2024 · Immunity · DOI

Full title: Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging.

Authors: Zhou, Zhao; Yao, Jingfei; Wu, Dongmei; Huang, Xun; Wang, Yushuang; Li, Xinmeng; Lu, Qiang; Qiu, Yifu

Year: 2024

Venue: Immunity

DOI: https://doi.org/10.1016/j.immuni.2024.01.001

Paper Senolytics and Senomorphics: natural and synthetic therapeutics in the treatment of aging and chronic diseases.

Sofia M Lagoumtzi; N. Chondrogianni · 2021 · Free Radical Biology & Medicine · DOI

Full title: Senolytics and Senomorphics: natural and synthetic therapeutics in the treatment of aging and chronic diseases.

Authors: Sofia M Lagoumtzi; N. Chondrogianni

Year: 2021

Venue: Free Radical Biology & Medicine

DOI: https://doi.org/10.1016/j.freeradbiomed.2021.05.003

Paper Unknown fates of (brain) oxidation or UFO: Close encounters with neuronal senescence.

Walton, Chaska C; Andersen, Julie K · 2019 · Free radical biology & medicine · DOI

Full title: Unknown fates of (brain) oxidation or UFO: Close encounters with neuronal senescence.

Authors: Walton, Chaska C; Andersen, Julie K

Year: 2019

Venue: Free radical biology & medicine

DOI: https://doi.org/10.1016/j.freeradbiomed.2019.01.012

Paper Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications.

Bacca, Luisa; Brandariz, Julian; Zacchi, Francesca et al. · 2025 · Gene · DOI

Full title: Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications.

Authors: Bacca, Luisa; Brandariz, Julian; Zacchi, Francesca; Zivi, Andrea; Mateo, Joaquin; Labbé, David P

Year: 2025

Venue: Gene

DOI: https://doi.org/10.1016/j.gene.2025.149774

Paper A senescence-responsive nanodrug amplifies radiotherapy efficacy.

Hua, Yu; Song, Hua; Deng, Hongpei et al. · 2025 · Journal of controlled release : official journal of the Controlled Release Society · DOI

Full title: A senescence-responsive nanodrug amplifies radiotherapy efficacy.

Authors: Hua, Yu; Song, Hua; Deng, Hongpei; Tian, Hao; Liu, Chang; Wu, Huiyi; Wang, Shaoyun; Shao, Chunlin; Ye, Lin; Ge, Shengfang; Leong, Kam W; Yu, Jie; Ruan, Jing

Year: 2025

Venue: Journal of controlled release : official journal of the Controlled Release Society

DOI: https://doi.org/10.1016/j.jconrel.2025.114202

Paper Evaluating causality of cellular senescence in non-alcoholic fatty liver disease

Abraham S. Meijnikman; H. Herrema; Torsten P. M. Scheithauer et al. · 2021 · JHEP Reports · DOI

Full title: Evaluating causality of cellular senescence in non-alcoholic fatty liver disease

Authors: Abraham S. Meijnikman; H. Herrema; Torsten P. M. Scheithauer; J. Kroon; M. Nieuwdorp; A. Groen

Year: 2021

Venue: JHEP Reports

DOI: https://doi.org/10.1016/j.jhepr.2021.100301

Paper Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases

Manish Kumar; Pengyi Yan; George A. Kuchel et al. · 2024 · JACC: Basic to Translational Science · DOI

Full title: Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases

Authors: Manish Kumar; Pengyi Yan; George A. Kuchel; Ming Xu

Year: 2024

Venue: JACC: Basic to Translational Science

DOI: https://doi.org/10.1016/j.jacbts.2023.12.003

Paper Cellular senescence in liver diseases: From molecular drivers to therapeutic targeting.

Du, Kuo; Umbaugh, David S; Ren, Niansheng et al. · 2026 · Journal of hepatology · DOI

Full title: Cellular senescence in liver diseases: From molecular drivers to therapeutic targeting.

Authors: Du, Kuo; Umbaugh, David S; Ren, Niansheng; Diehl, Anna Mae

Year: 2026

Venue: Journal of hepatology

DOI: https://doi.org/10.1016/j.jhep.2025.08.021

Paper Quantitative PET tracking of intra-articularly administered 89Zr-peptide-decorated nanoemulsions.

Díez-Villares, Sandra; García-Varela, Lara; Antas, Soraya Groba-de et al. · 2023 · Journal of controlled release : official journal of the Controlled Release Society · DOI

Full title: Quantitative PET tracking of intra-articularly administered 89Zr-peptide-decorated nanoemulsions.

Authors: Díez-Villares, Sandra; García-Varela, Lara; Antas, Soraya Groba-de; Caeiro, José Ramón; Carpintero-Fernandez, Paula; Mayán, María D; Aguiar, Pablo; de la Fuente, María

Year: 2023

Venue: Journal of controlled release : official journal of the Controlled Release Society

DOI: https://doi.org/10.1016/j.jconrel.2023.03.025

Paper Regulation of intestinal senescence during cholestatic liver disease modulates barrier function and liver disease progression.

Moreno-Gonzalez, Mar; Hampton, Katherine; Ruiz, Paula et al. · 2024 · JHEP reports : innovation in hepatology · DOI

Full title: Regulation of intestinal senescence during cholestatic liver disease modulates barrier function and liver disease progression.

Authors: Moreno-Gonzalez, Mar; Hampton, Katherine; Ruiz, Paula; Beasy, Gemma; Nagies, Falk Sp; Parker, Aimee; Lazenby, James; Bone, Caitlin; Alava-Arteaga, Ane; Patel, Meha; Hellmich, Charlotte; Luri-Martin, Pablo; Silan, Ece; Philo, Mark; Baker, David; Rushbrook, Simon M; Hildebrand, Falk; Rushworth, Stuart A; Beraza, Naiara

Year: 2024

Venue: JHEP reports : innovation in hepatology

DOI: https://doi.org/10.1016/j.jhepr.2024.101159

Paper Geroscience-Centric Perspective for Geriatric Psychiatry: Integrating Aging Biology With Geriatric Mental Health Research

Diniz, Breno S.; Seitz‐Holland, Johanna; Sehgal, Raghav et al. · 2023 · American Journal of Geriatric Psychiatry · DOI

Full title: Geroscience-Centric Perspective for Geriatric Psychiatry: Integrating Aging Biology With Geriatric Mental Health Research

Authors: Diniz, Breno S.; Seitz‐Holland, Johanna; Sehgal, Raghav; Kasamoto, Jessica; Higgins‐Chen, Albert; Lenze, Eric J.

Year: 2023

Venue: American Journal of Geriatric Psychiatry

DOI: https://doi.org/10.1016/j.jagp.2023.09.014

Paper Sex, ancestry, senescence, and aging (SAnSA) are stark drivers of nontuberculous mycobacterial pulmonary disease.

Fifor, Adrian; Krukowski, Karen; Honda, Jennifer R · 2022 · Journal of clinical tuberculosis and other mycobacterial diseases · DOI

Full title: Sex, ancestry, senescence, and aging (SAnSA) are stark drivers of nontuberculous mycobacterial pulmonary disease.

Authors: Fifor, Adrian; Krukowski, Karen; Honda, Jennifer R

Year: 2022

Venue: Journal of clinical tuberculosis and other mycobacterial diseases

DOI: https://doi.org/10.1016/j.jctube.2022.100297

Paper Molecular Mechanisms of Cellular Senescence in Neurodegenerative Diseases.

Lee, He-Jin; Yoon, Ye-Seul; Lee, Seung-Jae · 2023 · Journal of molecular biology · DOI

Full title: Molecular Mechanisms of Cellular Senescence in Neurodegenerative Diseases.

Authors: Lee, He-Jin; Yoon, Ye-Seul; Lee, Seung-Jae

Year: 2023

Venue: Journal of molecular biology

DOI: https://doi.org/10.1016/j.jmb.2023.168114

Paper Regulation of Survival Networks in Senescent Cells: From Mechanisms to Interventions.

Soto-Gamez, Abel; Quax, Wim J; Demaria, Marco · 2019 · Journal of molecular biology · DOI

Full title: Regulation of Survival Networks in Senescent Cells: From Mechanisms to Interventions.

Authors: Soto-Gamez, Abel; Quax, Wim J; Demaria, Marco

Year: 2019

Venue: Journal of molecular biology

DOI: https://doi.org/10.1016/j.jmb.2019.05.036

Paper Cellular Senescence and the Senescence-Associated Secretory Phenotype as Drivers of Skin Photoaging.

Fitsiou, Eleni; Pulido, Tanya; Campisi, Judith et al. · 2021 · The Journal of investigative dermatology · DOI

Full title: Cellular Senescence and the Senescence-Associated Secretory Phenotype as Drivers of Skin Photoaging.

Authors: Fitsiou, Eleni; Pulido, Tanya; Campisi, Judith; Alimirah, Fatouma; Demaria, Marco

Year: 2021

Venue: The Journal of investigative dermatology

DOI: https://doi.org/10.1016/j.jid.2020.09.031

Paper Aging and the emerging role of cellular senescence in osteoarthritis.

Diekman, Brian O; Loeser, Richard F · 2024 · Osteoarthritis and cartilage · DOI

Full title: Aging and the emerging role of cellular senescence in osteoarthritis.

Authors: Diekman, Brian O; Loeser, Richard F

Year: 2024

Venue: Osteoarthritis and cartilage

DOI: https://doi.org/10.1016/j.joca.2023.11.018

Paper Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.

Shao, Z; Wang, B; Shi, Y et al. · 2021 · Osteoarthritis and cartilage · DOI

Full title: Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.

Authors: Shao, Z; Wang, B; Shi, Y; Xie, C; Huang, C; Chen, B; Zhang, H; Zeng, G; Liang, H; Wu, Y; Zhou, Y; Tian, N; Wu, A; Gao, W; Wang, X; Zhang, X

Year: 2021

Venue: Osteoarthritis and cartilage

DOI: https://doi.org/10.1016/j.joca.2020.11.006

Paper Normothermic liver machine perfusion as a dynamic platform for regenerative purposes: What does the future have in store for us?

Lascaris, Bianca; Meijer, Vincent E. de; Porte, Robert J. · 2022 · Journal of Hepatology · DOI

Full title: Normothermic liver machine perfusion as a dynamic platform for regenerative purposes: What does the future have in store for us?

Authors: Lascaris, Bianca; Meijer, Vincent E. de; Porte, Robert J.

Year: 2022

Venue: Journal of Hepatology

DOI: https://doi.org/10.1016/j.jhep.2022.04.033

Paper A geroscience motivated approach to treat Alzheimer's disease: Senolytics move to clinical trials.

Gonzales, Mitzi M; Krishnamurthy, Sudarshan; Garbarino, Valentina et al. · 2021 · Mechanisms of ageing and development · DOI

Full title: A geroscience motivated approach to treat Alzheimer's disease: Senolytics move to clinical trials.

Authors: Gonzales, Mitzi M; Krishnamurthy, Sudarshan; Garbarino, Valentina; Daeihagh, Ali S; Gillispie, Gregory J; Deep, Gagan; Craft, Suzanne; Orr, Miranda E

Year: 2021

Venue: Mechanisms of ageing and development

DOI: https://doi.org/10.1016/j.mad.2021.111589

Paper Emerging senolytic agents derived from natural products

Wen Li; Lin Qin; R. Feng et al. · 2019 · Mechanisms of Ageing and Development · DOI

Full title: Emerging senolytic agents derived from natural products

Authors: Wen Li; Lin Qin; R. Feng; Guangrong Hu; Hui Sun; Yonghan He; Rongping Zhang

Year: 2019

Venue: Mechanisms of Ageing and Development

DOI: https://doi.org/10.1016/j.mad.2019.05.001

Paper Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice.

Chen, Peng; Wang, Yulai; Zhou, Benhong · 2024 · Mechanisms of ageing and development · DOI

Full title: Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice.

Authors: Chen, Peng; Wang, Yulai; Zhou, Benhong

Year: 2024

Venue: Mechanisms of ageing and development

DOI: https://doi.org/10.1016/j.mad.2024.111918

Paper Activatable senoprobes and senolytics: Novel strategies to detect and target senescent cells.

Samir Morsli; G. Doherty; D. Muñoz‐Espín · 2022 · Mechanisms of Ageing and Development · DOI

Full title: Activatable senoprobes and senolytics: Novel strategies to detect and target senescent cells.

Authors: Samir Morsli; G. Doherty; D. Muñoz‐Espín

Year: 2022

Venue: Mechanisms of Ageing and Development

DOI: https://doi.org/10.1016/j.mad.2021.111618

Paper The senolytic agent ABT263 ameliorates osteoporosis caused by active vitamin D insufficiency through selective clearance of senescent skeletal cells

Cuicui Yang; Wanxin Qiao; Qi Xue et al. · 2024 · Journal of Orthopaedic Translation · DOI

Full title: The senolytic agent ABT263 ameliorates osteoporosis caused by active vitamin D insufficiency through selective clearance of senescent skeletal cells

Authors: Cuicui Yang; Wanxin Qiao; Qi Xue; David Goltzman; Dengshun Miao; Zhan Dong

Year: 2024

Venue: Journal of Orthopaedic Translation

DOI: https://doi.org/10.1016/j.jot.2024.08.012

Paper Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironment.

Liu, Yang; Dou, Yiming; Sun, Xun et al. · 2024 · Journal of orthopaedic translation · DOI

Full title: Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironment.

Authors: Liu, Yang; Dou, Yiming; Sun, Xun; Yang, Qiang

Year: 2024

Venue: Journal of orthopaedic translation

DOI: https://doi.org/10.1016/j.jot.2024.02.003

Paper A guide to senolytic intervention in neurodegenerative disease.

Lee, Suckwon; Wang, Ellen Y; Steinberg, Alexandra B et al. · 2021 · Mechanisms of ageing and development · DOI

Full title: A guide to senolytic intervention in neurodegenerative disease.

Authors: Lee, Suckwon; Wang, Ellen Y; Steinberg, Alexandra B; Walton, Chaska C; Chinta, Shankar J; Andersen, Julie K

Year: 2021

Venue: Mechanisms of ageing and development

DOI: https://doi.org/10.1016/j.mad.2021.111585

Paper Targeting senescent chondrocytes in osteoarthritis: artificial intelligence powered target identification and hypothesis validation strategy

Monserrat, Jorge; Hudson, Christine C.; Small, J. Victor et al. · 2021 · Osteoarthritis and Cartilage · DOI

Full title: Targeting senescent chondrocytes in osteoarthritis: artificial intelligence powered target identification and hypothesis validation strategy

Authors: Monserrat, Jorge; Hudson, Christine C.; Small, J. Victor; Mak, Tytus D.; Richardson, Paul; Taddei, Andrea

Year: 2021

Venue: Osteoarthritis and Cartilage

DOI: https://doi.org/10.1016/j.joca.2021.02.542

Paper Quercetin induces senolysis of doxorubicin-induced senescent fibroblasts by reducing autophagy, preventing their pro-tumour effect on osteosarcoma cells.

Bientinesi, Elisa; Ristori, Sara; Lulli, Matteo et al. · 2024 · Mechanisms of ageing and development · DOI

Full title: Quercetin induces senolysis of doxorubicin-induced senescent fibroblasts by reducing autophagy, preventing their pro-tumour effect on osteosarcoma cells.

Authors: Bientinesi, Elisa; Ristori, Sara; Lulli, Matteo; Monti, Daniela

Year: 2024

Venue: Mechanisms of ageing and development

DOI: https://doi.org/10.1016/j.mad.2024.111957

Paper Senolytic targets and new strategies for clearing senescent cells.

Ge, Mingxia; Hu, Li; Ao, Hongshun et al. · 2021 · Mechanisms of ageing and development · DOI

Full title: Senolytic targets and new strategies for clearing senescent cells.

Authors: Ge, Mingxia; Hu, Li; Ao, Hongshun; Zi, Meiting; Kong, Qingpeng; He, Yonghan

Year: 2021

Venue: Mechanisms of ageing and development

DOI: https://doi.org/10.1016/j.mad.2021.111468

Paper Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids.

Scalise, Mariangela; Cianflone, Eleonora; Quercia, Claudia et al. · 2025 · Mechanisms of ageing and development · DOI

Full title: Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids.

Authors: Scalise, Mariangela; Cianflone, Eleonora; Quercia, Claudia; Pagano, Loredana; Chiefalo, Antonio; Stincelli, Antonio; Torella, Annalaura; Puccio, Barbara; Santamaria, Gianluca; Guzzi, Hiram P; Veltri, Pierangelo; De Angelis, Antonella; Urbanek, Konrad; Ellison-Hughes, Georgina M; Torella, Daniele; Marino, Fabiola

Year: 2025

Venue: Mechanisms of ageing and development

DOI: https://doi.org/10.1016/j.mad.2024.112007

Paper Reducing Senescent Cell Burden in Aging and Disease.

Pignolo, Robert J; Passos, João F; Khosla, Sundeep et al. · 2020 · Trends in molecular medicine · DOI

Full title: Reducing Senescent Cell Burden in Aging and Disease.

Authors: Pignolo, Robert J; Passos, João F; Khosla, Sundeep; Tchkonia, Tamara; Kirkland, James L

Year: 2020

Venue: Trends in molecular medicine

DOI: https://doi.org/10.1016/j.molmed.2020.03.005

Paper Cellular Senescence: The Sought or the Unwanted?

Sun, Yu; Coppé, Jean-Philippe; Lam, Eric W-F · 2018 · Trends in molecular medicine · DOI

Full title: Cellular Senescence: The Sought or the Unwanted?

Authors: Sun, Yu; Coppé, Jean-Philippe; Lam, Eric W-F

Year: 2018

Venue: Trends in molecular medicine

DOI: https://doi.org/10.1016/j.molmed.2018.08.002

Paper Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases.

Tavenier, Juliette; Nehlin, Jan O; Houlind, Morten Baltzer et al. · 2024 · Mechanisms of ageing and development · DOI

Full title: Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases.

Authors: Tavenier, Juliette; Nehlin, Jan O; Houlind, Morten Baltzer; Rasmussen, Lene Juel; Tchkonia, Tamara; Kirkland, James L; Andersen, Ove; Rasmussen, Line Jee Hartmann

Year: 2024

Venue: Mechanisms of ageing and development

DOI: https://doi.org/10.1016/j.mad.2024.111995

Paper Mitochondrial dysfunction and cell senescence: deciphering a complex relationship.

Chapman, James; Fielder, Edward; Passos, João F · 2019 · FEBS letters · DOI

Full title: Mitochondrial dysfunction and cell senescence: deciphering a complex relationship.

Authors: Chapman, James; Fielder, Edward; Passos, João F

Year: 2019

Venue: FEBS letters

DOI: https://doi.org/10.1002/1873-3468.13498

Paper Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities

Song, Shuling; Tchkonia, Tamar; Jiang, Jing et al. · 2020 · Advanced Science · DOI

Full title: Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities

Authors: Song, Shuling; Tchkonia, Tamar; Jiang, Jing; Kirkland, James L.; Sun, Yu

Year: 2020

Venue: Advanced Science

DOI: https://doi.org/10.1002/advs.202002611

Paper Cellular senescence and the tumour microenvironment

M. Takasugi; Y. Yoshida; Naoko Ohtani · 2022 · Molecular Oncology · DOI

Full title: Cellular senescence and the tumour microenvironment

Authors: M. Takasugi; Y. Yoshida; Naoko Ohtani

Year: 2022

Venue: Molecular Oncology

DOI: https://doi.org/10.1002/1878-0261.13268

Paper Targeting senescence as an anticancer therapy.

Bousset, Laura; Gil, Jesús · 2022 · Molecular oncology · DOI

Full title: Targeting senescence as an anticancer therapy.

Authors: Bousset, Laura; Gil, Jesús

Year: 2022

Venue: Molecular oncology

DOI: https://doi.org/10.1002/1878-0261.13312

Paper Senolytic Therapy Enabled by Senescent Cell-Sensitive Biomimetic Melanin Nano-Senolytics.

Zhang, Hairui; Xu, Xiaoling; Shou, Xin et al. · 2024 · Advanced healthcare materials · DOI

Full title: Senolytic Therapy Enabled by Senescent Cell-Sensitive Biomimetic Melanin Nano-Senolytics.

Authors: Zhang, Hairui; Xu, Xiaoling; Shou, Xin; Liao, Wucan; Jin, Chengkang; Chen, Changjiang; Zhang, Chen; Gao, Wenhua; Zhang, Junfeng; Ge, Weihong; Shi, Liyun

Year: 2024

Venue: Advanced healthcare materials

DOI: https://doi.org/10.1002/adhm.202401085

Paper Ligustilide, A Novel Senolytic Compound Isolated from the Roots of Angelica Acutiloba

Kento Takaya; Kazuo Kishi · 2024 · Advances in Biology · DOI

Full title: Ligustilide, A Novel Senolytic Compound Isolated from the Roots of Angelica Acutiloba

Authors: Kento Takaya; Kazuo Kishi

Year: 2024

Venue: Advances in Biology

DOI: https://doi.org/10.1002/adbi.202300434

Paper In Situ Remodeling of Efferocytosis via Lesion‐Localized Microspheres to Reverse Cartilage Senescence

Xiong, Wei; Han, Zeyu; Ding, Shenglong et al. · 2024 · Advanced Science · DOI

Full title: In Situ Remodeling of Efferocytosis via Lesion‐Localized Microspheres to Reverse Cartilage Senescence

Authors: Xiong, Wei; Han, Zeyu; Ding, Shenglong; Wang, Haoran; Du, Yawei; Cui, Wenguo; Zhang, Mingzhu

Year: 2024

Venue: Advanced Science

DOI: https://doi.org/10.1002/advs.202400345

Paper Bioinformatics procedure for investigating senolytic (anti-aging) agents: A digital signal processing technique.

Nwankwo, Norbert; Okafor, Ignatius · 2023 · Aging medicine (Milton (N.S.W)) · DOI

Full title: Bioinformatics procedure for investigating senolytic (anti-aging) agents: A digital signal processing technique.

Authors: Nwankwo, Norbert; Okafor, Ignatius

Year: 2023

Venue: Aging medicine (Milton (N.S.W))

DOI: https://doi.org/10.1002/agm2.12274

Paper Age‐associated Senescent – T Cell Signaling Promotes Type 3 Immunity that Inhibits the Biomaterial Regenerative Response

Han, Jin; Cherry, Christopher; Mejías, Joscelyn C. et al. · 2023 · Advanced Materials · DOI

Full title: Age‐associated Senescent – T Cell Signaling Promotes Type 3 Immunity that Inhibits the Biomaterial Regenerative Response

Authors: Han, Jin; Cherry, Christopher; Mejías, Joscelyn C.; Krishnan, Kavita; Ruta, Anna; Maestas, David R.; Peña, Alexis N.; Nguyễn, Helen; Nagaraj, Sushma; Yang, Brenda; Gray-Gaillard, Elise; Rutkowski, Natalie; Browne, Maria; Tam, Ada; Fertig, Elana J.; Housseau, Franck; Ganguly, Sudipto; Moore, Erika; Pardoll, Drew M.; Elisseeff, Jennifer H.

Year: 2023

Venue: Advanced Materials

DOI: https://doi.org/10.1002/adma.202310476

Paper Radiotherapy-Induced Astrocyte Senescence Promotes an Immunosuppressive Microenvironment in Glioblastoma to Facilitate Tumor Regrowth.

Ji, Jianxiong; Ding, Kaikai; Cheng, Bo et al. · 2024 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · DOI

Full title: Radiotherapy-Induced Astrocyte Senescence Promotes an Immunosuppressive Microenvironment in Glioblastoma to Facilitate Tumor Regrowth.

Authors: Ji, Jianxiong; Ding, Kaikai; Cheng, Bo; Zhang, Xin; Luo, Tao; Huang, Bin; Yu, Hao; Chen, Yike; Xu, Xiaohui; Lin, Haopu; Zhou, Jiayin; Wang, Tingtin; Jin, Mengmeng; Liu, Aixia; Yan, Danfang; Liu, Fuyi; Wang, Chun; Chen, Jingsen; Yan, Feng; Wang, Lin; Zhang, Jianmin; Yan, Senxiang; Wang, Jian; Li, Xingang; Chen, Gao

Year: 2024

Venue: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

DOI: https://doi.org/10.1002/advs.202304609

Paper Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies

Gaikwad, Sagar; Senapati, Sudipta; Haque, Md. Anzarul et al. · 2023 · Alzheimer s & Dementia · DOI

Full title: Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies

Authors: Gaikwad, Sagar; Senapati, Sudipta; Haque, Md. Anzarul; Kayed, Rakez

Year: 2023

Venue: Alzheimer s & Dementia

DOI: https://doi.org/10.1002/alz.13490

Paper Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Zhang, Hongwei; Xu, Qixia; Jiang, Zhirui et al. · 2025 · Advanced Science · DOI

Full title: Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Authors: Zhang, Hongwei; Xu, Qixia; Jiang, Zhirui; Sun, Rong; Wang, Qun; Liu, Sanhong; Luan, Xin; Makhijani, Priya; Kirkland, James L.; Zhang, Weidong; Sun, Yu

Year: 2025

Venue: Advanced Science

DOI: https://doi.org/10.1002/advs.202412950

Paper Endothelial cellular senescence and tau accumulation: An interplay full of opportunities?

Oliveri, D.; Moschetti, Giorgia; Griego, Anna et al. · 2024 · Ibrain · DOI

Full title: Endothelial cellular senescence and tau accumulation: An interplay full of opportunities?

Authors: Oliveri, D.; Moschetti, Giorgia; Griego, Anna; Scarpa, Edoardo

Year: 2024

Venue: Ibrain

DOI: https://doi.org/10.1002/ibra.12154

Paper CAR T cells: Building on the CD19 paradigm

Levin, Anat Globerson; Rivière, Isabelle; Eshhar, Zelig et al. · 2021 · European Journal of Immunology · DOI

Full title: CAR T cells: Building on the CD19 paradigm

Authors: Levin, Anat Globerson; Rivière, Isabelle; Eshhar, Zelig; Sadelain, Michel

Year: 2021

Venue: European Journal of Immunology

DOI: https://doi.org/10.1002/eji.202049064

Paper Inflammasome activation and metabolic remodelling in p16‐positive aging cells aggravates high‐fat diet‐induced lung fibrosis by inhibiting NEDD4L‐mediated K48‐polyubiquitin‐dependent degradation of SGK1

Xin Gu; H. Meng; Chengyi Peng et al. · 2023 · Clinical and Translational Medicine · DOI

Full title: Inflammasome activation and metabolic remodelling in p16‐positive aging cells aggravates high‐fat diet‐induced lung fibrosis by inhibiting NEDD4L‐mediated K48‐polyubiquitin‐dependent degradation of SGK1

Authors: Xin Gu; H. Meng; Chengyi Peng; Shiyu Lin; Baihong Li; Lin Zhao; Xue Yang; Guangyan Wang; W. Cai; Jiawen Zhou; Shuiyuan Liu; Peng Wu; Yingqiang Du; Jianliang Jin; Xiaoyan Wang

Year: 2023

Venue: Clinical and Translational Medicine

DOI: https://doi.org/10.1002/ctm2.1308

Paper New Horizons in Myotonic Dystrophy Type 1: Cellular Senescence as a Therapeutic Target.

Légaré, Cécilia; Berglund, J Andrew; Duchesne, Elise et al. · 2025 · BioEssays : news and reviews in molecular, cellular and developmental biology · DOI

Full title: New Horizons in Myotonic Dystrophy Type 1: Cellular Senescence as a Therapeutic Target.

Authors: Légaré, Cécilia; Berglund, J Andrew; Duchesne, Elise; Dumont, Nicolas A

Year: 2025

Venue: BioEssays : news and reviews in molecular, cellular and developmental biology

DOI: https://doi.org/10.1002/bies.202400216

Paper Strategies to Reduce the On‐Target Platelet Toxicity of Bcl‐xL Inhibitors: PROTACs, SNIPERs and Prodrug‐Based Approaches

Arvind Negi; A. Voisin‐Chiret · 2022 · ChemBioChem · DOI

Full title: Strategies to Reduce the On‐Target Platelet Toxicity of Bcl‐xL Inhibitors: PROTACs, SNIPERs and Prodrug‐Based Approaches

Authors: Arvind Negi; A. Voisin‐Chiret

Year: 2022

Venue: ChemBioChem

DOI: https://doi.org/10.1002/cbic.202100689

Paper Senescence Signature in Skin Biopsies From Systemic Sclerosis Patients Treated With Senolytic Therapy: Potential Predictor of Clinical Response?

V. Martyanov; M. Whitfield; J. Varga · 2019 · Arthritis & Rheumatology · DOI

Full title: Senescence Signature in Skin Biopsies From Systemic Sclerosis Patients Treated With Senolytic Therapy: Potential Predictor of Clinical Response?

Authors: V. Martyanov; M. Whitfield; J. Varga

Year: 2019

Venue: Arthritis & Rheumatology

DOI: https://doi.org/10.1002/art.40934

Paper Targeting senescence-associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomes.

Xiong, Jiaqiang; Dong, Lu; Lv, Qiongying et al. · 2024 · Clinical and translational medicine · DOI

Full title: Targeting senescence-associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomes.

Authors: Xiong, Jiaqiang; Dong, Lu; Lv, Qiongying; Yin, Yutong; Zhao, Jiahui; Ke, Youning; Wang, Shixuan; Zhang, Wei; Wu, Meng

Year: 2024

Venue: Clinical and translational medicine

DOI: https://doi.org/10.1002/ctm2.1772

Paper Dissecting Spatiotemporal Heterogeneity of Senescence Markers p16/p21 Across Tissues During Type 2 Diabetes Progression

Jiayu Yan; Zimei Yi; Siyi Chen et al. · 2025 · Cell Biochemistry and Function · DOI

Full title: Dissecting Spatiotemporal Heterogeneity of Senescence Markers p16/p21 Across Tissues During Type 2 Diabetes Progression

Authors: Jiayu Yan; Zimei Yi; Siyi Chen; Ruowen Zhao; Jiaying Shi; Shuwen Ding; Jiayu Zhu; Junhua Wu

Year: 2025

Venue: Cell Biochemistry and Function

DOI: https://doi.org/10.1002/cbf.70127

Paper Indication of Activated Senescence Pathways in the Temporal Arteries of Patients With Giant Cell Arteritis

Jiemy, William F.; Sleen, Yannick van; Graver, Jacoba C. et al. · 2023 · Arthritis & Rheumatology · DOI

Full title: Indication of Activated Senescence Pathways in the Temporal Arteries of Patients With Giant Cell Arteritis

Authors: Jiemy, William F.; Sleen, Yannick van; Graver, Jacoba C.; Pringle, Sarah; Brouwer, Elisabeth; Geest, Kornelis S. M. van der; Cornec, Divi; Boots, Annemieke M. H.; Sandovici, Maria

Year: 2023

Venue: Arthritis & Rheumatology

DOI: https://doi.org/10.1002/art.42525

Paper Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice

Yinhua Zhu; Ying Zhang; Qianyu Zhang et al. · 2025 · Exploration · DOI

Full title: Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice

Authors: Yinhua Zhu; Ying Zhang; Qianyu Zhang; Ping Song; Junzhe Zhang; Ang Ma; Chen Wang; Peng Gao; Tong Yang; Lirun Zhou; Qiaoli Shi; Yinkwan Wong; Yongting Luo; Huan Tang; Jigang Wang

Year: 2025

Venue: Exploration

DOI: https://doi.org/10.1002/exp.20240069

Paper Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues.

Fang, Zhuyubing; Raza, Umar; Song, Jia et al. · 2025 · ESC heart failure · DOI

Full title: Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues.

Authors: Fang, Zhuyubing; Raza, Umar; Song, Jia; Lu, Junyan; Yao, Shun; Liu, Xiaohong; Zhang, Wei; Li, Shujuan

Year: 2025

Venue: ESC heart failure

DOI: https://doi.org/10.1002/ehf2.14947

Paper Honokiol‐loaded nanomicelles reprogram senescence and immune evasion in hepatocellular carcinoma via SIRT3 ‐mediated mitochondrial stabilization

Wenxing Deng; Yizhi Wu; Yisheng Yin et al. · 2026 · Bioengineering & Translational Medicine · DOI

Full title: Honokiol‐loaded nanomicelles reprogram senescence and immune evasion in hepatocellular carcinoma via SIRT3 ‐mediated mitochondrial stabilization

Authors: Wenxing Deng; Yizhi Wu; Yisheng Yin; Jing Wang

Year: 2026

Venue: Bioengineering & Translational Medicine

DOI: https://doi.org/10.1002/btm2.70111

Paper Emerging role of cellular senescence in the pathogenesis of oral submucous fibrosis and its malignant transformation

Mohit Sharma; K. Hunter; F. Fonseca et al. · 2021 · Head and Neck · DOI

Full title: Emerging role of cellular senescence in the pathogenesis of oral submucous fibrosis and its malignant transformation

Authors: Mohit Sharma; K. Hunter; F. Fonseca; R. Radhakrishnan

Year: 2021

Venue: Head and Neck

DOI: https://doi.org/10.1002/hed.26805

Paper Tofacitinib treatment of rheumatoid arthritis increases senescent T cell frequency in patients and limits T cell function in vitro

Alamino, Vanina Alejandra; Onofrio, Luisina I.; Acosta, Cristina et al. · 2023 · European Journal of Immunology · DOI

Full title: Tofacitinib treatment of rheumatoid arthritis increases senescent T cell frequency in patients and limits T cell function in vitro

Authors: Alamino, Vanina Alejandra; Onofrio, Luisina I.; Acosta, Cristina; Ferrero, Paola; Zacca, Estefanía R.; Cadile, Isaac; Mussano, Eduardo; Onetti, Laura; Montes, Carolina L.; Gruppi, Adriana; Rodríguez, Eva V. Acosta

Year: 2023

Venue: European Journal of Immunology

DOI: https://doi.org/10.1002/eji.202250353

Paper The impact of senescence on muscle wasting in chronic kidney disease.

Huang, Ying; Wang, Bin; Hassounah, Faten et al. · 2023 · Journal of cachexia, sarcopenia and muscle · DOI

Full title: The impact of senescence on muscle wasting in chronic kidney disease.

Authors: Huang, Ying; Wang, Bin; Hassounah, Faten; Price, S Russ; Klein, Janet; Mohamed, Tamer M A; Wang, Yanhua; Park, Jeanie; Cai, Hui; Zhang, Xuemei; Wang, Xiaonan H

Year: 2023

Venue: Journal of cachexia, sarcopenia and muscle

DOI: https://doi.org/10.1002/jcsm.13112

Paper Targeting senescent cholangiocytes and activated fibroblasts with B‐cell lymphoma‐extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/− ) mice

Moncsek, Anja; Alsuraih, Mohammed; Trussoni, Christy E. et al. · 2017 · Hepatology · DOI

Full title: Targeting senescent cholangiocytes and activated fibroblasts with B‐cell lymphoma‐extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/− ) mice

Authors: Moncsek, Anja; Alsuraih, Mohammed; Trussoni, Christy E.; O’Hara, Steven P.; Splinter, Patrick L.; Zuber, Camille; Patsenker, Eleonora; Valli, Piero V.; Fingas, Christian D.; Weber, Achim; Zhu, Yi; Tchkonia, Tamar; Kirkland, James L.; Gores, Gregory J.; Müllhaupt, Beat; LaRusso, Nicholas F.; Mertens, Joachim C.

Year: 2017

Venue: Hepatology

DOI: https://doi.org/10.1002/hep.29464

Paper Bone Aging, Cellular Senescence, and Osteoporosis.

Pignolo, Robert J; Law, Susan F; Chandra, Abhishek · 2021 · JBMR plus · DOI

Full title: Bone Aging, Cellular Senescence, and Osteoporosis.

Authors: Pignolo, Robert J; Law, Susan F; Chandra, Abhishek

Year: 2021

Venue: JBMR plus

DOI: https://doi.org/10.1002/jbm4.10488

Paper Roles of extracellular vesicles in the aging microenvironment and age‐related diseases

Yin, Yujia; Chen, Huihui; Wang, Yizhi et al. · 2021 · Journal of Extracellular Vesicles · DOI

Full title: Roles of extracellular vesicles in the aging microenvironment and age‐related diseases

Authors: Yin, Yujia; Chen, Huihui; Wang, Yizhi; Zhang, Ludi; Wang, Xipeng

Year: 2021

Venue: Journal of Extracellular Vesicles

DOI: https://doi.org/10.1002/jev2.12154

Paper Pharmacologic Interventions for Fracture Risk Reduction in the Oldest Old: What Is the Evidence?

Sfeir, Jad; Pignolo, Robert J. · 2021 · JBMR Plus · DOI

Full title: Pharmacologic Interventions for Fracture Risk Reduction in the Oldest Old: What Is the Evidence?

Authors: Sfeir, Jad; Pignolo, Robert J.

Year: 2021

Venue: JBMR Plus

DOI: https://doi.org/10.1002/jbm4.10538

Paper Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy‐Related Bone Loss

Abhishek Chandra; A. Lagnado; J. Farr et al. · 2020 · Journal of Bone and Mineral Research · DOI

Full title: Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy‐Related Bone Loss

Authors: Abhishek Chandra; A. Lagnado; J. Farr; D. Monroe; Sean Park; Christine M. Hachfeld; T. Tchkonia; J. Kirkland; S. Khosla; J. Passos; R. Pignolo

Year: 2020

Venue: Journal of Bone and Mineral Research

DOI: https://doi.org/10.1002/jbmr.3978

Paper Screening of Natural Products for Senolytic or Senostatic Activities on Human Senescent Cells (SenoNPs)

S. Treibmann; A. Bhosale; I. Morgan et al. · 2025 · Lebensmittelchemie · DOI

Full title: Screening of Natural Products for Senolytic or Senostatic Activities on Human Senescent Cells (SenoNPs)

Authors: S. Treibmann; A. Bhosale; I. Morgan; R. Rennert; C. Correia‐Melo

Year: 2025

Venue: Lebensmittelchemie

DOI: https://doi.org/10.1002/lemi.202559196

Paper Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells

Seo Rin Kim; X. Zou; Hui Tang et al. · 2020 · Journal of Cellular Physiology · DOI

Full title: Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells

Authors: Seo Rin Kim; X. Zou; Hui Tang; A. Puranik; A. Abumoawad; Xiang-Yang Zhu; L. Hickson; T. Tchkonia; S. Textor; J. Kirkland; L. Lerman

Year: 2020

Venue: Journal of Cellular Physiology

DOI: https://doi.org/10.1002/jcp.29940

Paper Journal of Bone and Mineral Research: Volume 34, Number 11, November 2019

A. Cohen; Mafo Kamanda; Kosseh et al. · 2019 · Journal of Bone and Mineral Research · DOI

Full title: Journal of Bone and Mineral Research: Volume 34, Number 11, November 2019

Authors: A. Cohen; Mafo Kamanda; Kosseh; DAVID W. Dempster; Hua Zhou; Ralph Müller; Elliott Go; I. Colon; M. Bucovsky; J. Stubby; T. Nickolas; Emily M. Stein; R. Recker; J. Lappe; Elizabeth Shane

Year: 2019

Venue: Journal of Bone and Mineral Research

DOI: https://doi.org/10.1002/jbmr.3515

Paper Clearance of Senescent Cells From Injured Muscle Abrogates Heterotopic Ossification in Mouse Models of Fibrodysplasia Ossificans Progressiva

Haitao Wang; Qiang Zhang; F. Kaplan et al. · 2021 · Journal of Bone and Mineral Research · DOI

Full title: Clearance of Senescent Cells From Injured Muscle Abrogates Heterotopic Ossification in Mouse Models of Fibrodysplasia Ossificans Progressiva

Authors: Haitao Wang; Qiang Zhang; F. Kaplan; R. Pignolo

Year: 2021

Venue: Journal of Bone and Mineral Research

DOI: https://doi.org/10.1002/jbmr.4458

Paper The dual role of cellular senescence in human tumor progression and therapy.

Ma, Liang; Yu, Jie; Fu, Yidian et al. · 2024 · MedComm · DOI

Full title: The dual role of cellular senescence in human tumor progression and therapy.

Authors: Ma, Liang; Yu, Jie; Fu, Yidian; He, Xiaoyu; Ge, Shengfang; Jia, Renbing; Zhuang, Ai; Yang, Zhi; Fan, Xianqun

Year: 2024

Venue: MedComm

DOI: https://doi.org/10.1002/mco2.695

Paper Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans.

Farr, Joshua N; Rowsey, Jennifer L; Eckhardt, Brittany A et al. · 2019 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · DOI

Full title: Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans.

Authors: Farr, Joshua N; Rowsey, Jennifer L; Eckhardt, Brittany A; Thicke, Brianne S; Fraser, Daniel G; Tchkonia, Tamar; Kirkland, James L; Monroe, David G; Khosla, Sundeep

Year: 2019

Venue: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

DOI: https://doi.org/10.1002/jbmr.3729

Paper Cellular senescence in cancer: molecular mechanisms and therapeutic targets.

Jin, Ping; Duan, Xirui; Li, Lei et al. · 2024 · MedComm · DOI

Full title: Cellular senescence in cancer: molecular mechanisms and therapeutic targets.

Authors: Jin, Ping; Duan, Xirui; Li, Lei; Zhou, Ping; Zou, Cheng-Gang; Xie, Ke

Year: 2024

Venue: MedComm

DOI: https://doi.org/10.1002/mco2.542

Paper Application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro‐regenerative biomaterials in regenerative medicine

Li, Qianyi; Wang, Zhenzhen; Shi, Nuo et al. · 2023 · Smart Medicine · DOI

Full title: Application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro‐regenerative biomaterials in regenerative medicine

Authors: Li, Qianyi; Wang, Zhenzhen; Shi, Nuo; Yang, Qi; Yao, Wenfei; Yu, Jie; Lu, Yiming

Year: 2023

Venue: Smart Medicine

DOI: https://doi.org/10.1002/smmd.20230030

Paper Therapeutic potential of nicotinamide and ABT263 in alcohol‐associated liver disease through targeting cellular senescence

Naheemat Modupeola Gold; Qinchao Ding; Yang Yang et al. · 2025 · MedComm · DOI

Full title: Therapeutic potential of nicotinamide and ABT263 in alcohol‐associated liver disease through targeting cellular senescence

Authors: Naheemat Modupeola Gold; Qinchao Ding; Yang Yang; Shaoyan Pu; Wenjing Cao; Xinxuan Ge; Pengyun Yang; Michael Ngozi Okeke; Ayesha Nisar; Yongzhang Pan; Qiuni Luo; Xiayan Wang; Han Xu; Rui Tian; Meiting Zi; Xingjie Zhang; Songtao Li; Yonghan He

Year: 2025

Venue: MedComm

DOI: https://doi.org/10.1002/mco2.70086

Paper Emerging use of senolytics and senomorphics against aging and chronic diseases.

Martel, Jan; Ojcius, David M; Wu, Cheng-Yeu et al. · 2020 · Medicinal research reviews · DOI

Full title: Emerging use of senolytics and senomorphics against aging and chronic diseases.

Authors: Martel, Jan; Ojcius, David M; Wu, Cheng-Yeu; Peng, Hsin-Hsin; Voisin, Laurent; Perfettini, Jean-Luc; Ko, Yun-Fei; Young, John D

Year: 2020

Venue: Medicinal research reviews

DOI: https://doi.org/10.1002/med.21702

Paper Quercetin as a cancer chemopreventive or chemotherapeutic agent: Where we stand

A. Boretti · 2022 · Phytotherapy Research · DOI

Full title: Quercetin as a cancer chemopreventive or chemotherapeutic agent: Where we stand

Authors: A. Boretti

Year: 2022

Venue: Phytotherapy Research

DOI: https://doi.org/10.1002/ptr.7699

Paper Microglial senescence in neurodegeneration: Insights, implications, and therapeutic opportunities.

Samuel Olajide, Tobiloba; Oyerinde, Toheeb O; Omotosho, Omolabake I et al. · 2024 · Neuroprotection (Chichester, England) · DOI

Full title: Microglial senescence in neurodegeneration: Insights, implications, and therapeutic opportunities.

Authors: Samuel Olajide, Tobiloba; Oyerinde, Toheeb O; Omotosho, Omolabake I; Okeowo, Oritoke M; Olajide, Olayemi J; Ijomone, Omamuyouwi M

Year: 2024

Venue: Neuroprotection (Chichester, England)

DOI: https://doi.org/10.1002/nep3.56

Paper A Reporter Platform to Study Therapy‐Induced Senescence in Live Cancer Cells

Jacinta van de Grint; Mengqi Huang; Ruben Sangers et al. · 2025 · Small Methods · DOI

Full title: A Reporter Platform to Study Therapy‐Induced Senescence in Live Cancer Cells

Authors: Jacinta van de Grint; Mengqi Huang; Ruben Sangers; H. Odijk; Thom G A Reuvers; J. Heredia‐Genestar; Anja Raams; Tsung Wai Kan; J. Pothof; R. Kanaar; M. Kuijten

Year: 2025

Venue: Small Methods

DOI: https://doi.org/10.1002/smtd.202501270

Paper Celastrol Targets Hsc70-Bim Interaction as a Novel Senolytic to Extend Lifespan and Mitigate Organ Fibrosis.

Xu, Weitong; Chen, Honghan; Gong, Hui et al. · 2026 · Phytotherapy research : PTR · DOI

Full title: Celastrol Targets Hsc70-Bim Interaction as a Novel Senolytic to Extend Lifespan and Mitigate Organ Fibrosis.

Authors: Xu, Weitong; Chen, Honghan; Gong, Hui; Zhao, Tingting; Yang, Yu; Wang, Fangfang; Huang, Ning; Yang, Ming; Gao, Nan; Li, Huan; Huang, Xiaoli; Li, Ying; Xiao, Hengyi

Year: 2026

Venue: Phytotherapy research : PTR

DOI: https://doi.org/10.1002/ptr.70220

Paper Fisetin Clears Senescent Cells Through the Pi3k-Akt-Bcl-2/Bcl-xl Pathway to Alleviate Diabetic Aortic Aging.

Ji, Xiao-Man; Dong, Xin-Xin; Li, Jia-Peng et al. · 2025 · Phytotherapy research : PTR · DOI

Full title: Fisetin Clears Senescent Cells Through the Pi3k-Akt-Bcl-2/Bcl-xl Pathway to Alleviate Diabetic Aortic Aging.

Authors: Ji, Xiao-Man; Dong, Xin-Xin; Li, Jia-Peng; Tai, Guang-Jie; Qiu, Shu; Wei, Wei; Silumbwe, Ceaser Wankumbu; Damdinjav, Davaadagva; Otieno, Joseph Nicolao; Li, Xiao-Xue; Xu, Ming

Year: 2025

Venue: Phytotherapy research : PTR

DOI: https://doi.org/10.1002/ptr.8507

Paper Selective kidney targeting increases the efficacy of mesenchymal stromal/stem cells for alleviation of murine stenotic-kidney senescence and damage.

Kim, Seo Rin; Jiang, Kai; Chen, Xiaojun et al. · 2022 · Journal of tissue engineering and regenerative medicine · DOI

Full title: Selective kidney targeting increases the efficacy of mesenchymal stromal/stem cells for alleviation of murine stenotic-kidney senescence and damage.

Authors: Kim, Seo Rin; Jiang, Kai; Chen, Xiaojun; Puranik, Amrutesh S; Zhu, Xiang-Yang; Lerman, Amir; Tchkonia, Tamara; Kirkland, James L; Lerman, Lilach O

Year: 2022

Venue: Journal of tissue engineering and regenerative medicine

DOI: https://doi.org/10.1002/term.3299

Paper Obesity, Senescence, and Senolytics.

Selim Chaib; T. Tchkonia; J. Kirkland · 2021 · Handbook of Experimental Pharmacology · DOI

Full title: Obesity, Senescence, and Senolytics.

Authors: Selim Chaib; T. Tchkonia; J. Kirkland

Year: 2021

Venue: Handbook of Experimental Pharmacology

DOI: https://doi.org/10.1007/164_2021_555

Paper Senescence in the pathogenesis of age-related macular degeneration.

Blasiak, Janusz · 2020 · Cellular and molecular life sciences : CMLS · DOI

Full title: Senescence in the pathogenesis of age-related macular degeneration.

Authors: Blasiak, Janusz

Year: 2020

Venue: Cellular and molecular life sciences : CMLS

DOI: https://doi.org/10.1007/s00018-019-03420-x

Paper Anthracycline-induced cardiotoxicity and cell senescence: new therapeutic option?

Seara, Fernando A C; Kasai-Brunswick, Tais H; Nascimento, Jose H M et al. · 2022 · Cellular and molecular life sciences : CMLS · DOI

Full title: Anthracycline-induced cardiotoxicity and cell senescence: new therapeutic option?

Authors: Seara, Fernando A C; Kasai-Brunswick, Tais H; Nascimento, Jose H M; Campos-de-Carvalho, Antonio C

Year: 2022

Venue: Cellular and molecular life sciences : CMLS

DOI: https://doi.org/10.1007/s00018-022-04605-7

Paper Discovery of Senolytics and the Pathway to Early Phase Clinical Trials

E. Gerdes; Yi Zhu; T. Tchkonia et al. · 2020 · DOI

Full title: Discovery of Senolytics and the Pathway to Early Phase Clinical Trials

Authors: E. Gerdes; Yi Zhu; T. Tchkonia; J. Kirkland

Year: 2020

DOI: https://doi.org/10.1007/978-3-030-44903-2_2

Paper Quercetin influences intestinal dysbacteriosis and delays alveolar epithelial cell senescence by regulating PTEN/PI3K/AKT signaling in pulmonary fibrosis

Wu, Wenjuan; Wu, Xinhui; Qiu, Lingxiao et al. · 2023 · Naunyn-Schmiedeberg s Archives of Pharmacology · DOI

Full title: Quercetin influences intestinal dysbacteriosis and delays alveolar epithelial cell senescence by regulating PTEN/PI3K/AKT signaling in pulmonary fibrosis

Authors: Wu, Wenjuan; Wu, Xinhui; Qiu, Lingxiao; Wan, Ruijie; Zhu, Xiaoming; Chen, Song; Xinying, Yang; Liu, Xueya; Wu, Jizhen

Year: 2023

Venue: Naunyn-Schmiedeberg s Archives of Pharmacology

DOI: https://doi.org/10.1007/s00210-023-02913-8

Paper Nutritional components as mitigators of cellular senescence in organismal aging: a comprehensive review

Diwan, Bhawna; Sharma, Rohit · 2022 · Food Science and Biotechnology · DOI

Full title: Nutritional components as mitigators of cellular senescence in organismal aging: a comprehensive review

Authors: Diwan, Bhawna; Sharma, Rohit

Year: 2022

Venue: Food Science and Biotechnology

DOI: https://doi.org/10.1007/s10068-022-01114-y

Paper Senotherapy: growing old and staying young?

Schmitt, Roland · 2017 · Pflugers Archiv : European journal of physiology · DOI

Full title: Senotherapy: growing old and staying young?

Authors: Schmitt, Roland

Year: 2017

Venue: Pflugers Archiv : European journal of physiology

DOI: https://doi.org/10.1007/s00424-017-1972-4

Paper Removing therapy-induced senescent cancer cells targets and potentiates the response of pancreatic cancer cells toward PARP inhibitors as maintenance therapy.

Li, Yupeng; Jia, Zhangjun; Liu, Xiaolin et al. · 2026 · Apoptosis : an international journal on programmed cell death · DOI

Full title: Removing therapy-induced senescent cancer cells targets and potentiates the response of pancreatic cancer cells toward PARP inhibitors as maintenance therapy.

Authors: Li, Yupeng; Jia, Zhangjun; Liu, Xiaolin; Xia, Xue'er; Zhang, Lingkai; Dai, Haoran; Li, Shaoqiu; Zhou, Yiran; Ma, Lingman; Bai, Zhaoshi

Year: 2026

Venue: Apoptosis : an international journal on programmed cell death

DOI: https://doi.org/10.1007/s10495-025-02251-5

Paper Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway.

Kumar, Ravi; Sharma, Anamika; Kumari, Amita et al. · 2019 · Biogerontology · DOI

Full title: Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway.

Authors: Kumar, Ravi; Sharma, Anamika; Kumari, Amita; Gulati, Ashu; Padwad, Yogendra; Sharma, Rohit

Year: 2019

Venue: Biogerontology

DOI: https://doi.org/10.1007/s10522-018-9785-1

Paper Hypertension and cellular senescence.

Afsar, Baris; Afsar, Rengin Elsurer · 2023 · Biogerontology · DOI

Full title: Hypertension and cellular senescence.

Authors: Afsar, Baris; Afsar, Rengin Elsurer

Year: 2023

Venue: Biogerontology

DOI: https://doi.org/10.1007/s10522-023-10031-4

Paper The potential of flavonoids to mitigate cellular senescence in cardiovascular disease.

Zheng, Huimin; Li, Tiantian; Hu, Ziyun et al. · 2024 · Biogerontology · DOI

Full title: The potential of flavonoids to mitigate cellular senescence in cardiovascular disease.

Authors: Zheng, Huimin; Li, Tiantian; Hu, Ziyun; Zheng, Qi; Wang, Junsong

Year: 2024

Venue: Biogerontology

DOI: https://doi.org/10.1007/s10522-024-10141-7

Paper Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components

Sharma, Rohit; Diwan, Bhawna; Sharma, Anamika et al. · 2022 · Biogerontology · DOI

Full title: Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components

Authors: Sharma, Rohit; Diwan, Bhawna; Sharma, Anamika; Witkowski, Jacek M.

Year: 2022

Venue: Biogerontology

DOI: https://doi.org/10.1007/s10522-022-09995-6

Paper Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?

Ademowo, Opeyemi Stella; Dias, Irundika H.K.; Burton, Dominick G. A. et al. · 2017 · Biogerontology · DOI

Full title: Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?

Authors: Ademowo, Opeyemi Stella; Dias, Irundika H.K.; Burton, Dominick G. A.; Griffiths, Helen R.

Year: 2017

Venue: Biogerontology

DOI: https://doi.org/10.1007/s10522-017-9710-z

Paper Mitochondria-targeted senotherapeutic interventions

M. Atayik; U. Çakatay · 2022 · Biogerontology (Dordrecht) · DOI

Full title: Mitochondria-targeted senotherapeutic interventions

Authors: M. Atayik; U. Çakatay

Year: 2022

Venue: Biogerontology (Dordrecht)

DOI: https://doi.org/10.1007/s10522-022-09973-y

Paper 3D models to study therapy-induced senescence: where do we stand now?

Heydari, Zahra; Malogolovkin, Alexander; Smirnova, Olga et al. · 2025 · Cytotechnology · DOI

Full title: 3D models to study therapy-induced senescence: where do we stand now?

Authors: Heydari, Zahra; Malogolovkin, Alexander; Smirnova, Olga; Lyukmanov, Damir; Filimonova, Alina; Shpichka, Anastasia; Vosough, Massoud; Timashev, Peter

Year: 2025

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-025-00774-y

Paper Identification of resibufogenin, a component of toad venom, as a novel senolytic compound in vitro and for potential skin rejuvenation in male mice

Kento Takaya; T. Asou; Kazuo Kishi · 2023 · Biogerontology (Dordrecht) · DOI

Full title: Identification of resibufogenin, a component of toad venom, as a novel senolytic compound in vitro and for potential skin rejuvenation in male mice

Authors: Kento Takaya; T. Asou; Kazuo Kishi

Year: 2023

Venue: Biogerontology (Dordrecht)

DOI: https://doi.org/10.1007/s10522-023-10043-0

Paper Elimination of p19 ARF ‐expressing cells protects against pulmonary emphysema in mice

Mikawa, Ryuta; Suzuki, Yohei; Baskoro, Hario et al. · 2018 · Aging Cell · DOI

Full title: Elimination of p19 ARF ‐expressing cells protects against pulmonary emphysema in mice

Authors: Mikawa, Ryuta; Suzuki, Yohei; Baskoro, Hario; Kanayama, Kazuki; Sugimoto, Kazushi; Sato, Tadashi; Sugimoto, Masataka

Year: 2018

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.12827

Paper Tau protein aggregation is associated with cellular senescence in the brain.

Musi, Nicolas; Valentine, Joseph M; Sickora, Kathryn R et al. · 2018 · Aging cell · DOI

Full title: Tau protein aggregation is associated with cellular senescence in the brain.

Authors: Musi, Nicolas; Valentine, Joseph M; Sickora, Kathryn R; Baeuerle, Eric; Thompson, Cody S; Shen, Qiang; Orr, Miranda E

Year: 2018

Venue: Aging cell

DOI: https://doi.org/10.1111/acel.12840

Paper DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age

Ha-Neui Kim; Jianhui Chang; Lijian Shao et al. · 2017 · Aging Cell · DOI

Full title: DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age

Authors: Ha-Neui Kim; Jianhui Chang; Lijian Shao; Li Han; Srividhya Iyer; S. Manolagas; C. O’Brien; R. Jilka; Daohong Zhou; Maria Almeida

Year: 2017

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.12597

Paper Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic

Moskalev, Alexey; Chernyagina, Elizaveta; Tsvetkov, Vasily O. et al. · 2016 · Aging Cell · DOI

Full title: Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic

Authors: Moskalev, Alexey; Chernyagina, Elizaveta; Tsvetkov, Vasily O.; Fedintsev, Alexander; Shaposhnikov, Mikhail; Крутько, В. Н.; Zhavoronkov, Alex; Kennedy, Brian K.

Year: 2016

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.12463

Paper Oxidation resistance 1 is a novel senolytic target.

Zhang, Xin; Zhang, Suping; Liu, Xingui et al. · 2018 · Aging cell · DOI

Full title: Oxidation resistance 1 is a novel senolytic target.

Authors: Zhang, Xin; Zhang, Suping; Liu, Xingui; Wang, Yingying; Chang, Jianhui; Zhang, Xuan; Mackintosh, Samuel G; Tackett, Alan J; He, Yonghan; Lv, Dongwen; Laberge, Remi-Martin; Campisi, Judith; Wang, Jianrong; Zheng, Guangrong; Zhou, Daohong

Year: 2018

Venue: Aging cell

DOI: https://doi.org/10.1111/acel.12780

Paper Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress.

Novoa, Beatriz; Pereiro, Patricia; López-Muñoz, Azucena et al. · 2019 · Aging cell · DOI

Full title: Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress.

Authors: Novoa, Beatriz; Pereiro, Patricia; López-Muñoz, Azucena; Varela, Mónica; Forn-Cuní, Gabriel; Anchelin, Monique; Dios, Sonia; Romero, Alejandro; Martinez-López, Alicia; Medina-Gali, Regla María; Collado, Manuel; Coll, Julio; Estepa, Amparo; Cayuela, María Luisa; Mulero, Victoriano; Figueras, Antonio

Year: 2019

Venue: Aging cell

DOI: https://doi.org/10.1111/acel.13020

Paper Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity

Yonghan He; Wen Li; D. Lv et al. · 2020 · Aging Cell · DOI

Full title: Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity

Authors: Yonghan He; Wen Li; D. Lv; Xin Zhang; Xuan Zhang; Yuma T. Ortiz; Vivekananda Budamagunta; J. Campisi; Guangrong Zheng; Daohong Zhou

Year: 2020

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.13117

Paper Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2nd Scripps Symposium on the Biology of Aging

Robbins, Paul D.; Niedernhofer, Laura J. · 2017 · Aging Cell · DOI

Full title: Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2nd Scripps Symposium on the Biology of Aging

Authors: Robbins, Paul D.; Niedernhofer, Laura J.

Year: 2017

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.12620

Paper Senescent cells: A new Achilles' heel to exploit for cancer medicine?

Zhang, Boyi; Lam, Eric W-F; Sun, Yu · 2019 · Aging cell · DOI

Full title: Senescent cells: A new Achilles' heel to exploit for cancer medicine?

Authors: Zhang, Boyi; Lam, Eric W-F; Sun, Yu

Year: 2019

Venue: Aging cell

DOI: https://doi.org/10.1111/acel.12875

Paper Aged‐senescent cells contribute to impaired heart regeneration

Fiona C Lewis-McDougall; P. Ruchaya; Eva Domenjo-Vila et al. · 2018 · bioRxiv · DOI

Full title: Aged‐senescent cells contribute to impaired heart regeneration

Year: 2018

Venue: bioRxiv

DOI: https://doi.org/10.1111/acel.12931

Paper Senolytics alleviate the degenerative disorders of temporomandibular joint in old age

Yueying Zhou; I. Al-Naggar; Po-Jung Chen et al. · 2021 · Aging Cell · DOI

Full title: Senolytics alleviate the degenerative disorders of temporomandibular joint in old age

Authors: Yueying Zhou; I. Al-Naggar; Po-Jung Chen; Nathan S. Gasek; Ke Wang; Shivam Mehta; G. Kuchel; S. Yadav; Ming Xu

Year: 2021

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.13394

Paper Measuring biological aging in humans: A quest

Ferrucci, Luigi; González‐Freire, Marta; Fabbri, Elisa et al. · 2019 · Aging Cell · DOI

Full title: Measuring biological aging in humans: A quest

Authors: Ferrucci, Luigi; González‐Freire, Marta; Fabbri, Elisa; Simonsick, Eleanor M.; Tanaka, Toshiko; Moore, Zenobia; Salimi, Shabnam; Sierra, Felipe; Cabo, Rafael de

Year: 2019

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.13080

Paper Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma

Nidheesh Thadathil; R. Selvarani; Sabira Mohammed et al. · 2022 · bioRxiv · DOI

Full title: Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma

Authors: Nidheesh Thadathil; R. Selvarani; Sabira Mohammed; Evan H Nicklas; Albert L Tran; M. Kamal; W. Luo; Jacob L Brown; M. Lawrence; Agnieszka K. Borowik; Benjamin F. Miller; H. Van Remmen; A. Richardson; S. S. Deepa

Year: 2022

Venue: bioRxiv

DOI: https://doi.org/10.1111/acel.13676

Paper Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age

M. Islam; Eric Tuday; Shanena Allen et al. · 2023 · Aging Cell · DOI

Full title: Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age

Authors: M. Islam; Eric Tuday; Shanena Allen; John Kim; Daniel W. Trott; W. Holland; A. Donato; L. Lesniewski

Year: 2023

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.13767

Paper Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

González‐Gualda, Estela; Pàez‐Ribes, Marta; Lozano‐Torres, Beatriz et al. · 2020 · Aging Cell · DOI

Full title: Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

Authors: González‐Gualda, Estela; Pàez‐Ribes, Marta; Lozano‐Torres, Beatriz; Macías, David; Wilson, J. Richard; González‐López, Cristina; Ou, Hui‐Ling; Mirón‐Barroso, Sofía; Zhang, Zhenguang; Lérida‐Viso, Araceli; Blandez, Juan F.; Bernardos, Andrea; Sancenón, Félix; Rovira, Miguel; Fruk, Ljiljana; Martins, Carla P.; Serrano, Manuel; Doherty, Gary J.; Martínez‐Máñez, Ramón; Muñoz‐Espín, Daniel

Year: 2020

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.13142

Paper Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension

L. Rocha; Viet Anh Nguyen Huu; Claudia Palomino La Torre et al. · 2019 · bioRxiv · DOI

Full title: Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension

Authors: L. Rocha; Viet Anh Nguyen Huu; Claudia Palomino La Torre; Qianlan Xu; M. Jabari; M. Krawczyk; R. Weinreb; Dorota Skowronska-Krawczyk

Year: 2019

Venue: bioRxiv

DOI: https://doi.org/10.1111/acel.13089

Paper NAD metabolism: Role in senescence regulation and aging

Chini, Claudia C.S.; Cordeiro, Heidi Soares; Tran, Ngan et al. · 2023 · Aging Cell · DOI

Full title: NAD metabolism: Role in senescence regulation and aging

Authors: Chini, Claudia C.S.; Cordeiro, Heidi Soares; Tran, Ngan; Chini, Eduardo N.

Year: 2023

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.13920

Paper Transplanting cells from old but not young donors causes physical dysfunction in older recipients

Wang, Binsheng; Liu, Zukai; Chen, Vicky P. et al. · 2020 · Aging Cell · DOI

Full title: Transplanting cells from old but not young donors causes physical dysfunction in older recipients

Authors: Wang, Binsheng; Liu, Zukai; Chen, Vicky P.; Wang, Lichao; Inman, Christina L.; Zhou, Yueying; Guo, Chun; Tchkonia, Tamar; Rowe, David W.; Kuchel, George A.; Robson, Paul; Kirkland, James L.; Xu, Ming

Year: 2020

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.13106

Paper Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal.

Kuehnemann, Chisaka; Hughes, Jun-Wei B; Desprez, Pierre-Yves et al. · 2023 · Aging cell · DOI

Full title: Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal.

Authors: Kuehnemann, Chisaka; Hughes, Jun-Wei B; Desprez, Pierre-Yves; Melov, Simon; Wiley, Christopher D; Campisi, Judith

Year: 2023

Venue: Aging cell

DOI: https://doi.org/10.1111/acel.13750

Paper A p21‐GFP zebrafish model of senescence for rapid testing of senolytics in vivo

Samir Morsli; C. Henriques; P. Ellis et al. · 2022 · bioRxiv · DOI

Full title: A p21‐GFP zebrafish model of senescence for rapid testing of senolytics in vivo

Authors: Samir Morsli; C. Henriques; P. Ellis; H. Mortiboys; S. Baxendale; Catherine A. Loynes; S. Renshaw; I. Bellantuono

Year: 2022

Venue: bioRxiv

DOI: https://doi.org/10.1111/acel.13835

Paper Cellular senescence as a potential mediator of COVID‐19 severity in the elderly

Nehme, Jamil; Borghesan, Michela; Mackedenski, Sebastian et al. · 2020 · Aging Cell · DOI

Full title: Cellular senescence as a potential mediator of COVID‐19 severity in the elderly

Authors: Nehme, Jamil; Borghesan, Michela; Mackedenski, Sebastian; Bird, Thomas G.; Demaria, Marco

Year: 2020

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.13237

Paper Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy

Liu, Hanxin; Xu, Qixia; Wufuer, Halidan et al. · 2023 · Aging Cell · DOI

Full title: Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy

Authors: Liu, Hanxin; Xu, Qixia; Wufuer, Halidan; Li, Zi; Sun, Rong; Jiang, Zhirui; Dou, Xuefeng; Fu, Qiang; Campisi, Judith; Sun, Yu

Year: 2023

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.13921

Paper Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

M. Ogrodnik; Shane A. Evans; E. Fielder et al. · 2021 · Aging Cell · DOI

Full title: Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

Authors: M. Ogrodnik; Shane A. Evans; E. Fielder; Stella G. Victorelli; Patrick J Kruger; Hanna Salmonowicz; B. M. Weigand; A. D. Patel; T. Pirtskhalava; C. Inman; Kurt O. Johnson; Stephanie L. Dickinson; Azucena Rocha; M. Schafer; Yi Zhu; D. Allison; T. von Zglinicki; N. LeBrasseur; T. Tchkonia; N. Neretti; J. Passos; J. Kirkland; D. Jurk

Year: 2021

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.13296

Paper Strategies for senolytic drug discovery

H. Power; P. Valtchev; F. Dehghani et al. · 2023 · Aging Cell · DOI

Full title: Strategies for senolytic drug discovery

Authors: H. Power; P. Valtchev; F. Dehghani; A. Schindeler

Year: 2023

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.13948

Paper Protein phosphatase 2A activators reverse age‐related behavioral changes by targeting neural cell senescence

Jun Xing; Ke Chen; Shu Gao et al. · 2023 · Aging Cell · DOI

Full title: Protein phosphatase 2A activators reverse age‐related behavioral changes by targeting neural cell senescence

Authors: Jun Xing; Ke Chen; Shu Gao; Mélanie Pousse; Yilin Ying; Bo Wang; Lianxiang Chen; Cuicui Wang; Lei Wang; Weiguo Hu; Yi-ming Lu; E. Gilson; Jing Ye

Year: 2023

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.13780

Paper Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)‐induced chemobrain

Ahire, Chetan; Nyúl‐Tóth, Ádám; DelFavero, Jordan et al. · 2023 · Aging Cell · DOI

Full title: Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)‐induced chemobrain

Authors: Ahire, Chetan; Nyúl‐Tóth, Ádám; DelFavero, Jordan; Gulej, Rafał; Faakye, Janet; Tarantini, Stefano; Kiss, Tamás; Kuan‐Celarier, Anna; Balasubramanian, Priya; Ungvari, Anna; Tarantini, Amber; Nagaraja, Raghavendra Y.; Yan, Feng; Tang, Qinggong; Mukli, Péter; Csípő, Tamás; Yabluchanskiy, Andriy; Campisi, Judith; Ungvári, Zoltán; Csiszár, Anna

Year: 2023

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.13832

Paper Depletion of preexisting B‐cell lymphoma 2‐expressing senescent cells before vaccination impacts antigen‐specific antitumor immune responses in old mice

Ozmen Çobanoğlu; Lou Delval; Daniele P. Ferrari et al. · 2023 · Aging Cell · DOI

Full title: Depletion of preexisting B‐cell lymphoma 2‐expressing senescent cells before vaccination impacts antigen‐specific antitumor immune responses in old mice

Authors: Ozmen Çobanoğlu; Lou Delval; Daniele P. Ferrari; L. Deruyter; S. Heumel; Isabelle Wolowczuk; Abir Hussein; A. Menevse; David Bernard; Philip Beckhove; Frauke Alves; F. Trottein

Year: 2023

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.14007

Paper Senescent cells at the crossroads of aging, disease, and tissue homeostasis.

Kuehnemann, Chisaka; Wiley, Christopher D · 2024 · Aging cell · DOI

Full title: Senescent cells at the crossroads of aging, disease, and tissue homeostasis.

Authors: Kuehnemann, Chisaka; Wiley, Christopher D

Year: 2024

Venue: Aging cell

DOI: https://doi.org/10.1111/acel.13988

Paper Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging

Wang, Haojue; Yuan, Tao; Wang, Yi et al. · 2024 · Aging Cell · DOI

Full title: Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging

Authors: Wang, Haojue; Yuan, Tao; Wang, Yi; Liu, Changxing; Li, Dengju; Li, Ziqing; Sun, Shui

Year: 2024

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.14092

Paper Effect of peripheral cellular senescence on brain aging and cognitive decline.

Budamagunta, Vivekananda; Kumar, Ashok; Rani, Asha et al. · 2023 · Aging cell · DOI

Full title: Effect of peripheral cellular senescence on brain aging and cognitive decline.

Authors: Budamagunta, Vivekananda; Kumar, Ashok; Rani, Asha; Bean, Linda; Manohar-Sindhu, Sahana; Yang, Yang; Zhou, Daohong; Foster, Thomas C

Year: 2023

Venue: Aging cell

DOI: https://doi.org/10.1111/acel.13817

Paper Senolytic treatment alleviates doxorubicin-induced chemobrain.

Budamagunta, Vivekananda; Kumar, Ashok; Rani, Asha et al. · 2024 · Aging cell · DOI

Full title: Senolytic treatment alleviates doxorubicin-induced chemobrain.

Authors: Budamagunta, Vivekananda; Kumar, Ashok; Rani, Asha; Manohar Sindhu, Sahana; Yang, Yang; Zhou, Daohong; Foster, Thomas C

Year: 2024

Venue: Aging cell

DOI: https://doi.org/10.1111/acel.14037

Paper Targeting the redox system for cardiovascular regeneration in aging

Allemann, Meret; Lee, Pratintip; Beer, Jürg H. et al. · 2023 · Aging Cell · DOI

Full title: Targeting the redox system for cardiovascular regeneration in aging

Authors: Allemann, Meret; Lee, Pratintip; Beer, Jürg H.; Saravi, Seyed Soheil Saeedi

Year: 2023

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.14020

Paper Clinical validation of C12FDG as a marker associated with senescence and osteoarthritic phenotypes

W. S. Hambright; Victoria R. Duke; Adam D Goff et al. · 2024 · Aging Cell · DOI

Full title: Clinical validation of C12FDG as a marker associated with senescence and osteoarthritic phenotypes

Authors: W. S. Hambright; Victoria R. Duke; Adam D Goff; Alexander Goff; Lucas T Minas; Heidi Kloser; Xueqin Gao; Charles A Huard; Ping Guo; Aiping Lu; John Mitchell; M. Mullen; Charles Su; T. Tchkonia; Jair M Espindola Netto; Paul D. Robbins; L. Niedernhofer; J. L. Kirkland; Chelsea S Bahney; Marc J. Philippon; Johnny Huard

Year: 2024

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.14113

Paper A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

S. Atlante; Luca Cis; Davide Pirolli et al. · 2025 · Aging Cell · DOI

Full title: A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

Authors: S. Atlante; Luca Cis; Davide Pirolli; M. Gottardi Zamperla; V. Barbi; Antonello Mai; Clemens Zwergel; Serena Marcozzi; M. E. Giuliani; Giorgia Bigossi; Giovanni Lai; Fiorenza Orlando; R. Giacconi; F. Lattanzio; Giulia Matacchione; Chiara Giordani; Massimo Bracci; Fabiola Olivieri; Federico Boschi; P. Tabarelli De Fatis; G. Ivaldi; Marco Malavolta; A. Farsetti; M. C. De Rosa; C. Gaetano

Year: 2025

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.70047

Paper Late Life Supplementation of 25‐Hydroxycholesterol Reduces Aortic Stiffness and Cellular Senescence in Mice

S. Mahoney; Mary A Darrah; Ravinandan Venkatasubramanian et al. · 2025 · Aging Cell · DOI

Full title: Late Life Supplementation of 25‐Hydroxycholesterol Reduces Aortic Stiffness and Cellular Senescence in Mice

Authors: S. Mahoney; Mary A Darrah; Ravinandan Venkatasubramanian; Serban Ciotlos; Matthew J. Rossman; Judith Campisi; Douglas R. Seals; Simon Melov; Zachary S. Clayton

Year: 2025

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.70118

Paper The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu; T. Tchkonia; T. Pirtskhalava et al. · 2015 · Aging Cell · DOI

Full title: The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Authors: Yi Zhu; T. Tchkonia; T. Pirtskhalava; A. Gower; H. Ding; N. Giorgadze; Allyson K. Palmer; Y. Ikeno; G. Hubbard; M. Lenburg; S. O’Hara; N. LaRusso; Jordan D. Miller; Carolyn M. Roos; Grace C. Verzosa; N. LeBrasseur; J. Wren; J. Farr; S. Khosla; Michael B. Stout; S. McGowan; Heike Fuhrmann-Stroissnigg; Aditi U. Gurkar; J. Zhao; D. Colangelo; A. Dorronsoro; Y. Ling; Amira S Barghouthy; D. C. Navarro; T. Sano; P. Robbins; L. Niedernhofer; J. Kirkland

Year: 2015

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.12344

Paper A novel senolytic drug for pulmonary fibrosis: BTSA1 targets apoptosis of senescent myofibroblasts by activating BAX.

Shen, Mengxia; Fu, Jiafeng; Zhang, Yunna et al. · 2024 · Aging cell · DOI

Full title: A novel senolytic drug for pulmonary fibrosis: BTSA1 targets apoptosis of senescent myofibroblasts by activating BAX.

Authors: Shen, Mengxia; Fu, Jiafeng; Zhang, Yunna; Chang, Yanfen; Li, Xiaohong; Cheng, Haipeng; Qiu, Yujia; Shao, Min; Han, Yang; Zhou, Yan; Luo, Ziqiang

Year: 2024

Venue: Aging cell

DOI: https://doi.org/10.1111/acel.14229

Paper Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers

Utkarsh Tripathi; Masayoshi Suda; Vagisha Kulshreshtha et al. · 2025 · bioRxiv · DOI

Full title: Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.08.27.672709

Paper Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence

S. Mahoney; Ravinandan Venkatasubramanian; Mary A Darrah et al. · 2023 · Aging Cell · DOI

Full title: Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence

Authors: S. Mahoney; Ravinandan Venkatasubramanian; Mary A Darrah; Katelyn R. Ludwig; Nicholas S. VanDongen; Nathan T Greenberg; Abigail G. Longtine; David A. Hutton; Vienna E. Brunt; Judith Campisi; S. Melov; D. Seals; Matthew J. Rossman; Zachary S. Clayton

Year: 2023

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.14060

Paper Microphysiological systems for human aging research

Park, Seungman; Laskow, Thomas; Chen, Jingchun et al. · 2024 · Aging Cell · DOI

Full title: Microphysiological systems for human aging research

Authors: Park, Seungman; Laskow, Thomas; Chen, Jingchun; Guha, Prasun; Dawn, Buddhadeb; Kim, Deok‐Ho

Year: 2024

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.14070

Paper Targeting IGF1-Induced Cellular Senescence to Rejuvenate Hair Follicle Aging.

Wang, Yang; Yang, Jian; Luo, Yue et al. · 2025 · Aging cell · DOI

Full title: Targeting IGF1-Induced Cellular Senescence to Rejuvenate Hair Follicle Aging.

Authors: Wang, Yang; Yang, Jian; Luo, Yue; Zhao, Zhiqiang; Yuan, Yawen; Li, Juan; Liu, Yang; Yi, Yong; Xu, Xiaoke; Lan, Yuankunyu; Zou, Juan; Li, Qintong; Wang, Liang; Pan, Yang; Yang, Yuanhan; Xiong, Muzhao; Wu, Min; Li, Jinsong; Li, Weiyuxin; Zhang, Yujun; Cao, Yang; Zhu, Yi; Xiao, Zhi-Xiong Jim

Year: 2025

Venue: Aging cell

DOI: https://doi.org/10.1111/acel.70053

Paper Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging.

Baier, Matthew P; Ranjit, Rojina; Owen, Daniel B et al. · 2025 · Aging cell · DOI

Full title: Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging.

Authors: Baier, Matthew P; Ranjit, Rojina; Owen, Daniel B; Wilson, Jenna L; Stiles, Megan A; Masingale, Anthony M; Thomas, Zachary; Bredegaard, Anne; Sherry, David M; Logan, Sreemathi

Year: 2025

Venue: Aging cell

DOI: https://doi.org/10.1111/acel.70041

Paper Restoration of hair follicle inductive properties by depletion of senescent cells

A. Pappalardo; Jin Yong Kim; H. Abaci et al. · 2024 · Aging Cell · DOI

Full title: Restoration of hair follicle inductive properties by depletion of senescent cells

Authors: A. Pappalardo; Jin Yong Kim; H. Abaci; Angela M Christiano

Year: 2024

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.14353

Paper Asparaginase and Autophagy Inhibitors Effectively Remove Senescent Cells by Synergistically Limiting Asparagine Supply.

Huang, Zhihua; Liu, Xinxin; Zhou, Xiaojia et al. · 2025 · Aging cell · DOI

Full title: Asparaginase and Autophagy Inhibitors Effectively Remove Senescent Cells by Synergistically Limiting Asparagine Supply.

Authors: Huang, Zhihua; Liu, Xinxin; Zhou, Xiaojia; Chen, Keyu; Diao, Honglin; Wang, Mingyue; Wei, Jianlei; Li, Zeping; Yang, Yang; Mao, Zebin; Yu, Wenhua

Year: 2025

Venue: Aging cell

DOI: https://doi.org/10.1111/acel.70203

Paper Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro-Inflammatory Phenotype of Senescent Cells.

Jiang, Birong; Zhang, Hongwei; Xu, Qixia et al. · 2025 · Aging cell · DOI

Full title: Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro-Inflammatory Phenotype of Senescent Cells.

Authors: Jiang, Birong; Zhang, Hongwei; Xu, Qixia; Jiang, Zhirui; He, Ruikun; Fu, Qiang; Sun, Yu

Year: 2025

Venue: Aging cell

DOI: https://doi.org/10.1111/acel.70138

Paper A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Zhen Feng; Cheuk Shuen Li; Haifeng Fu et al. · 2026 · Aging Cell · DOI

Full title: A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Authors: Zhen Feng; Cheuk Shuen Li; Haifeng Fu; Wenxin Jiang; Weiyu Zhang; Yingzhang Huang; Yunying Huang; Timothy Theodore Ka Ki Tam; Yang Li; Fang Liu; Liming Lu; Yin Lau Lee; W. S. Yeung; Gordon Dougan; Pentao Liu

Year: 2026

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.70352

Paper Senescent Microglia Mediate Neuroinflammation‐Induced Cognitive Dysfunction by Selective Elimination of Excitatory Synapses in the Hippocampal CA1

Kai Liu; Di Fan; Hai-peng Wu et al. · 2025 · Aging Cell · DOI

Full title: Senescent Microglia Mediate Neuroinflammation‐Induced Cognitive Dysfunction by Selective Elimination of Excitatory Synapses in the Hippocampal CA1

Authors: Kai Liu; Di Fan; Hai-peng Wu; Xiao-yi Hu; Qiu-li He; Xin-miao Wu; Cui-na Shi; Jian-jun Yang; Muhuo Ji

Year: 2025

Venue: Aging Cell

DOI: https://doi.org/10.1111/acel.70167

Paper Novel therapeutic approaches to target neurodegeneration

Fuente, Alerie Guzman de la; Pelucchi, Silvia; Mertens, Jérôme et al. · 2023 · British Journal of Pharmacology · DOI

Full title: Novel therapeutic approaches to target neurodegeneration

Authors: Fuente, Alerie Guzman de la; Pelucchi, Silvia; Mertens, Jérôme; Luca, Mónica Di; Mauceri, Daniela; Marcello, Elena

Year: 2023

Venue: British Journal of Pharmacology

DOI: https://doi.org/10.1111/bph.16078

Paper Cellular senescence contributes to spontaneous repair of the rat meniscus.

Aimono, Yusuke; Endo, Kentaro; Sekiya, Ichiro · 2025 · Aging cell · DOI

Full title: Cellular senescence contributes to spontaneous repair of the rat meniscus.

Authors: Aimono, Yusuke; Endo, Kentaro; Sekiya, Ichiro

Year: 2025

Venue: Aging cell

DOI: https://doi.org/10.1111/acel.14385

Paper Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology

Roth‐Walter, Franziska; Adcock, Ian M.; Benito‐Villalvilla, Cristina et al. · 2023 · Allergy · DOI

Authors: Roth‐Walter, Franziska; Adcock, Ian M.; Benito‐Villalvilla, Cristina; Bianchini, Rodolfo; Bjermer, Leif; Caramori, Gaetano; Cari, Luigi; Chung, Kian Fan; Diamant, Zuzana; Eguíluz‐Gracia, Ibon; Knol, Edward F.; Jeseňák, Miloš; Levi‐Schaffer, Francesca; Nocentini, Giuseppe; O’Mahony, Liam; Palomares, Óscar; Redegeld, Frank A.; Sokołowska, Milena; Esch, Betty C. A. M. van; Stellato, Cristiana

Year: 2023

Venue: Allergy

DOI: https://doi.org/10.1111/all.15977

Paper Discovery, development, and future application of senolytics: theories and predictions

Erin O. Wissler Gerdes; Yi Zhu; T. Tchkonia et al. · 2020 · The FEBS Journal · DOI

Full title: Discovery, development, and future application of senolytics: theories and predictions

Authors: Erin O. Wissler Gerdes; Yi Zhu; T. Tchkonia; J. Kirkland

Year: 2020

Venue: The FEBS Journal

DOI: https://doi.org/10.1111/febs.15264

Paper Inflammation, ageing and diseases of the lung: Potential therapeutic strategies from shared biological pathways

Faniyi, Aduragbemi A.; Hughes, Michael; Scott, Aaron et al. · 2021 · British Journal of Pharmacology · DOI

Full title: Inflammation, ageing and diseases of the lung: Potential therapeutic strategies from shared biological pathways

Authors: Faniyi, Aduragbemi A.; Hughes, Michael; Scott, Aaron; Belchamber, Kylie; Sapey, Elizabeth

Year: 2021

Venue: British Journal of Pharmacology

DOI: https://doi.org/10.1111/bph.15759

Paper Targeting senescence to prevent diabetic kidney disease: Exploring molecular mechanisms and potential therapeutic targets for disease management.

Phillips, Paige Charlotte Alison; de Sousa Loreto Aresta Branco, Mafalda; Cliff, Chelsy Louise et al. · 2025 · Diabetic medicine : a journal of the British Diabetic Association · DOI

Full title: Targeting senescence to prevent diabetic kidney disease: Exploring molecular mechanisms and potential therapeutic targets for disease management.

Authors: Phillips, Paige Charlotte Alison; de Sousa Loreto Aresta Branco, Mafalda; Cliff, Chelsy Louise; Ward, Joanna Kate; Squires, Paul Edward; Hills, Claire Elizabeth

Year: 2025

Venue: Diabetic medicine : a journal of the British Diabetic Association

DOI: https://doi.org/10.1111/dme.15408

Paper CAR T therapy from haematological malignancies to aging‐related diseases: An ever‐expanding universe

Ramoni, Davide; Montecucco, Fabrizio; Carbone, Federico · 2024 · European Journal of Clinical Investigation · DOI

Full title: CAR T therapy from haematological malignancies to aging‐related diseases: An ever‐expanding universe

Authors: Ramoni, Davide; Montecucco, Fabrizio; Carbone, Federico

Year: 2024

Venue: European Journal of Clinical Investigation

DOI: https://doi.org/10.1111/eci.14203

Paper Cellular senescence in giant cell arteritis and polymyalgia rheumatica: From mechanisms to therapeutic opportunities.

Luo, Yiting; Yang, Fan; He, Yanlin et al. · 2026 · European journal of clinical investigation · DOI

Full title: Cellular senescence in giant cell arteritis and polymyalgia rheumatica: From mechanisms to therapeutic opportunities.

Authors: Luo, Yiting; Yang, Fan; He, Yanlin; Lin, Jin; Chen, Weiqian

Year: 2026

Venue: European journal of clinical investigation

DOI: https://doi.org/10.1111/eci.70166

Paper The potential skin‐lightening candidate, senolytic drug ABT263, for photoageing pigmentation

J. Park; J. E. Yoon; Y. H. Kim et al. · 2021 · British Journal of Dermatology · DOI

Full title: The potential skin‐lightening candidate, senolytic drug ABT263, for photoageing pigmentation

Authors: J. Park; J. E. Yoon; Y. H. Kim; Y. Kim; T. J. Park; H. Kang

Year: 2021

Venue: British Journal of Dermatology

DOI: https://doi.org/10.1111/bjd.20893

Paper MicroRNA‐guided drug discovery for mitigating persistent pulmonary complications in critical COVID‐19 survivors: A longitudinal pilot study

García‐Hidalgo, María C.; Benítez, Iván D.; Perez‐Pons, Manel et al. · 2024 · British Journal of Pharmacology · DOI

Full title: MicroRNA‐guided drug discovery for mitigating persistent pulmonary complications in critical COVID‐19 survivors: A longitudinal pilot study

Authors: García‐Hidalgo, María C.; Benítez, Iván D.; Perez‐Pons, Manel; Molinero, Marta; Belmonte, Thalía; Rodríguez‐Muñoz, Carlos; Águilà, María; Santisteve, Sally; Torres, Gerard; Moncusí‐Moix, Anna; Gort‐Paniello, Clara; Peláez, Rafael; Larráyoz, Ignacio M.; Caballero, Jesús; Barberà, Carme; Nova‐Lamperti, Estefanía; Torres, Antoní; González, Jessica; Barbé, Ferrán; Gonzalo‐Calvo, David de

Year: 2024

Venue: British Journal of Pharmacology

DOI: https://doi.org/10.1111/bph.16330

Paper Effects of senescence on the tumour microenvironment and response to therapy

Louise Reynolds; Seynab Maallin; S. Haston et al. · 2023 · The FEBS Journal · DOI

Full title: Effects of senescence on the tumour microenvironment and response to therapy

Authors: Louise Reynolds; Seynab Maallin; S. Haston; J. Martínez-Barbera; K. Hodivala-Dilke; A. Pedrosa

Year: 2023

Venue: The FEBS Journal

DOI: https://doi.org/10.1111/febs.16984

Paper Depletion of SASP senescent cardiomyocytes with senolytic drugs confers therapeutic effects in doxorubicin-related cardiotoxicity.

Xia, Wenzheng; Chen, Hanbin; Yang, Han et al. · 2024 · The FEBS journal · DOI

Full title: Depletion of SASP senescent cardiomyocytes with senolytic drugs confers therapeutic effects in doxorubicin-related cardiotoxicity.

Authors: Xia, Wenzheng; Chen, Hanbin; Yang, Han; Zhu, Liaoxiang; Xie, Congying; Hou, Meng

Year: 2024

Venue: The FEBS journal

DOI: https://doi.org/10.1111/febs.17164

Paper Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control.

Cavinato, Maria; Madreiter-Sokolowski, Corina T; Büttner, Sabrina et al. · 2021 · The FEBS journal · DOI

Full title: Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control.

Authors: Cavinato, Maria; Madreiter-Sokolowski, Corina T; Büttner, Sabrina; Schosserer, Markus; Zwerschke, Werner; Wedel, Sophia; Grillari, Johannes; Graier, Wolfgang F; Jansen-Dürr, Pidder

Year: 2021

Venue: The FEBS journal

DOI: https://doi.org/10.1111/febs.15631

Paper The role of cellular senescence and SASP in tumour microenvironment.

Takasugi, Masaki; Yoshida, Yuya; Hara, Eiji et al. · 2023 · The FEBS journal · DOI

Full title: The role of cellular senescence and SASP in tumour microenvironment.

Authors: Takasugi, Masaki; Yoshida, Yuya; Hara, Eiji; Ohtani, Naoko

Year: 2023

Venue: The FEBS journal

DOI: https://doi.org/10.1111/febs.16381

Paper Transcriptomic signatures and network-based methods uncover new senescent cell anti-apoptotic pathways and senolytics.

Olascoaga, Samael; Konigsberg, Mina; Espinal-Enríquez, Jesús et al. · 2025 · The FEBS journal · DOI

Full title: Transcriptomic signatures and network-based methods uncover new senescent cell anti-apoptotic pathways and senolytics.

Authors: Olascoaga, Samael; Konigsberg, Mina; Espinal-Enríquez, Jesús; Tovar, Hugo; Matadamas-Martínez, Félix; Pérez-Villanueva, Jaime; López-Diazguerrero, Norma Edith

Year: 2025

Venue: The FEBS journal

DOI: https://doi.org/10.1111/febs.17402

Paper Cellular senescence as a source of SARS‐CoV‐2 quasispecies

Karakasiliοtis, Ioannis; Lаgopati, Nefeli; Evangelou, Konstantinos et al. · 2021 · FEBS Journal · DOI

Full title: Cellular senescence as a source of SARS‐CoV‐2 quasispecies

Authors: Karakasiliοtis, Ioannis; Lаgopati, Nefeli; Evangelou, Konstantinos; Gorgoulis, Vassilis G.

Year: 2021

Venue: FEBS Journal

DOI: https://doi.org/10.1111/febs.16230

Paper Targeting cellular senescence: A promising approach in respiratory diseases.

Sugimoto, Masataka · 2024 · Geriatrics & gerontology international · DOI

Full title: Targeting cellular senescence: A promising approach in respiratory diseases.

Authors: Sugimoto, Masataka

Year: 2024

Venue: Geriatrics & gerontology international

DOI: https://doi.org/10.1111/ggi.14653

Paper Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era.

Verdoorn, Brandon P; Evans, Tamara K; Hanson, Gregory J et al. · 2021 · Journal of the American Geriatrics Society · DOI

Full title: Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era.

Authors: Verdoorn, Brandon P; Evans, Tamara K; Hanson, Gregory J; Zhu, Yi; Langhi Prata, Larissa G P; Pignolo, Robert J; Atkinson, Elizabeth J; Wissler-Gerdes, Erin O; Kuchel, George A; Mannick, Joan B; Kritchevsky, Stephen B; Khosla, Sundeep; Rizza, Stacey A; Walston, Jeremy D; Musi, Nicolas; Lipsitz, Lewis A; Kiel, Douglas P; Yung, Raymond; LeBrasseur, Nathan K; Singh, Ravinder J; McCarthy, Teresa; Puskarich, Michael A; Niedernhofer, Laura J; Robbins, Paul D; Sorenson, Matthew; Tchkonia, Tamara; Kirkland, James L

Year: 2021

Venue: Journal of the American Geriatrics Society

DOI: https://doi.org/10.1111/jgs.17416

Paper Senescent T cells: Beneficial and detrimental roles

Laphanuwat, Phatthamon; Gomes, Daniel Cláudio Oliveira; Akbar, Arne N. · 2023 · Immunological Reviews · DOI

Full title: Senescent T cells: Beneficial and detrimental roles

Authors: Laphanuwat, Phatthamon; Gomes, Daniel Cláudio Oliveira; Akbar, Arne N.

Year: 2023

Venue: Immunological Reviews

DOI: https://doi.org/10.1111/imr.13206

Paper Senolytic chimeric antigen receptor (CAR) T cell: driving the immune system to fight cell senescence

Hajdu, Karina Lôbo; Bonamino, Martín · 2020 · Immunology and Cell Biology · DOI

Full title: Senolytic chimeric antigen receptor (CAR) T cell: driving the immune system to fight cell senescence

Authors: Hajdu, Karina Lôbo; Bonamino, Martín

Year: 2020

Venue: Immunology and Cell Biology

DOI: https://doi.org/10.1111/imcb.12391

Paper The Clinical Potential of Senolytic Drugs.

Kirkland, James L; Tchkonia, Tamara; Zhu, Yi et al. · 2017 · Journal of the American Geriatrics Society · DOI

Full title: The Clinical Potential of Senolytic Drugs.

Authors: Kirkland, James L; Tchkonia, Tamara; Zhu, Yi; Niedernhofer, Laura J; Robbins, Paul D

Year: 2017

Venue: Journal of the American Geriatrics Society

DOI: https://doi.org/10.1111/jgs.14969

Paper From Neuron-Centric to Glia-Centric: How Aging Glial Networks Drive Neurodegenerative Disease.

Hayashide, Lívia de Sá; Pessoa, Bruna; Dias, Gustavo et al. · 2026 · Journal of neurochemistry · DOI

Full title: From Neuron-Centric to Glia-Centric: How Aging Glial Networks Drive Neurodegenerative Disease.

Authors: Hayashide, Lívia de Sá; Pessoa, Bruna; Dias, Gustavo; Pontes, Bruno; Pinto, Rafael Serafim; Diniz, Luan Pereira

Year: 2026

Venue: Journal of neurochemistry

DOI: https://doi.org/10.1111/jnc.70361

Paper Therapeutic opportunities for senolysis in cardiovascular disease

M. Sweeney; S. Cook; Jesús Gil · 2022 · The FEBS Journal · DOI

Full title: Therapeutic opportunities for senolysis in cardiovascular disease

Authors: M. Sweeney; S. Cook; Jesús Gil

Year: 2022

Venue: The FEBS Journal

DOI: https://doi.org/10.1111/febs.16351

Paper Cellular senescence in the pathogenesis of ovarian dysfunction

M. Harada · 2024 · The journal of obstetrics and gynaecology research · DOI

Full title: Cellular senescence in the pathogenesis of ovarian dysfunction

Authors: M. Harada

Year: 2024

Venue: The journal of obstetrics and gynaecology research

DOI: https://doi.org/10.1111/jog.15918

Paper Cellular senescence: beneficial, harmful, and highly complex

D. Baker; M. Narita; P. Muñoz-Cánoves · 2023 · The FEBS Journal · DOI

Full title: Cellular senescence: beneficial, harmful, and highly complex

Authors: D. Baker; M. Narita; P. Muñoz-Cánoves

Year: 2023

Venue: The FEBS Journal

DOI: https://doi.org/10.1111/febs.16735

Paper Cellular Senescence, Inflammaging and Cardiovascular Disease

Lukas Zanders; Denada Arifaj; Julian U. G. Wagner et al. · 2026 · Immunological Reviews · DOI

Full title: Cellular Senescence, Inflammaging and Cardiovascular Disease

Authors: Lukas Zanders; Denada Arifaj; Julian U. G. Wagner; S. Dimmeler

Year: 2026

Venue: Immunological Reviews

DOI: https://doi.org/10.1111/imr.70084

Paper FOXO4 peptide targets myofibroblast ameliorates bleomycin‐induced pulmonary fibrosis in mice through ECM‐receptor interaction pathway

Han, Xiaodan; Yuan, Tong; Zhang, Junling et al. · 2022 · Journal of Cellular and Molecular Medicine · DOI

Full title: FOXO4 peptide targets myofibroblast ameliorates bleomycin‐induced pulmonary fibrosis in mice through ECM‐receptor interaction pathway

Authors: Han, Xiaodan; Yuan, Tong; Zhang, Junling; Shi, Yonggang; Li, Deguan; Dong, Yinping; Fan, Saijun

Year: 2022

Venue: Journal of Cellular and Molecular Medicine

DOI: https://doi.org/10.1111/jcmm.17333

Paper Looking for the philosopher's stone: Emerging approaches to target the hallmarks of aging in the skin

J. Lemaître · 2024 · Journal of the European Academy of Dermatology and Venereology · DOI

Full title: Looking for the philosopher's stone: Emerging approaches to target the hallmarks of aging in the skin

Authors: J. Lemaître

Year: 2024

Venue: Journal of the European Academy of Dermatology and Venereology

DOI: https://doi.org/10.1111/jdv.19820

Paper Cell senescence in neuropathology: A focus on neurodegeneration and tumours.

Carreno, Gabriela; Guiho, Romain; Martinez-Barbera, Juan Pedro · 2021 · Neuropathology and applied neurobiology · DOI

Full title: Cell senescence in neuropathology: A focus on neurodegeneration and tumours.

Authors: Carreno, Gabriela; Guiho, Romain; Martinez-Barbera, Juan Pedro

Year: 2021

Venue: Neuropathology and applied neurobiology

DOI: https://doi.org/10.1111/nan.12689

Paper Senotherapeutics for metabolic disease and diabetic complications

Allyson K. Palmer; Rosa Spinelli; L. Prata et al. · 2025 · Journal of Internal Medicine · DOI

Full title: Senotherapeutics for metabolic disease and diabetic complications

Authors: Allyson K. Palmer; Rosa Spinelli; L. Prata; Selim Chaib; Masayoshi Suda; Tamar Tchkonia; Ulf Smith; James L. Kirkland

Year: 2025

Venue: Journal of Internal Medicine

DOI: https://doi.org/10.1111/joim.70039

Paper High-dimensionality Data Analysis of Pharmacological Systems Associated with Complex Diseases

Hendrickx, Jhana O.; Gastel, Jaana van; Leysen, Hanne et al. · 2019 · Pharmacological Reviews · DOI

Full title: High-dimensionality Data Analysis of Pharmacological Systems Associated with Complex Diseases

Authors: Hendrickx, Jhana O.; Gastel, Jaana van; Leysen, Hanne; Martin, Bronwen; Maudsley, Stuart

Year: 2019

Venue: Pharmacological Reviews

DOI: https://doi.org/10.1124/pr.119.017921

Paper Senolytic drugs: from discovery to translation.

Kirkland, J L; Tchkonia, T · 2020 · Journal of internal medicine · DOI

Full title: Senolytic drugs: from discovery to translation.

Authors: Kirkland, J L; Tchkonia, T

Year: 2020

Venue: Journal of internal medicine

DOI: https://doi.org/10.1111/joim.13141

Paper Dasatinib and Quercetin Mitigate Age-Related Alveolar Bone Inflammaging and Neutrophil Infiltration.

Tang, Jinru; Li, Jingya; Hou, Zeyu et al. · 2025 · Oral diseases · DOI

Full title: Dasatinib and Quercetin Mitigate Age-Related Alveolar Bone Inflammaging and Neutrophil Infiltration.

Authors: Tang, Jinru; Li, Jingya; Hou, Zeyu; He, Rong; Li, Bingzhi; Gong, Jiajing; Xie, Yuhang; Meng, Wanrong; Liu, Yunkun; Ouchi, Takehito; Li, Longjiang; Li, Bo

Year: 2025

Venue: Oral diseases

DOI: https://doi.org/10.1111/odi.15291

Paper Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies.

Lucas, Vasco; Cavadas, Cláudia; Aveleira, Célia Alexandra · 2023 · Pharmacological reviews · DOI

Full title: Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies.

Authors: Lucas, Vasco; Cavadas, Cláudia; Aveleira, Célia Alexandra

Year: 2023

Venue: Pharmacological reviews

DOI: https://doi.org/10.1124/pharmrev.122.000622

Paper Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair

K. Mylonas; E. O’Sullivan; Duncan C. Humphries et al. · 2021 · Science Translational Medicine · DOI

Full title: Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair

Authors: K. Mylonas; E. O’Sullivan; Duncan C. Humphries; David P. Baird; M. Docherty; Sarah A. Neely; P. Krimpenfort; A. Melk; R. Schmitt; Sofía Ferreira-González; S. Forbes; J. Hughes; D. Ferenbach

Year: 2021

Venue: Science Translational Medicine

DOI: https://doi.org/10.1126/scitranslmed.abb0203

Paper Pharmacological Targeting of Senescence with Senolytics as a New Therapeutic Strategy for Neurodegeneration.

Richardson, Miriam; Richardson, Des R · 2024 · Molecular pharmacology · DOI

Full title: Pharmacological Targeting of Senescence with Senolytics as a New Therapeutic Strategy for Neurodegeneration.

Authors: Richardson, Miriam; Richardson, Des R

Year: 2024

Venue: Molecular pharmacology

DOI: https://doi.org/10.1124/molpharm.123.000803

Paper Myofibroblast fate plasticity in tissue repair and fibrosis: Deactivation, apoptosis, senescence and reprogramming.

Merkt, Wolfgang; Zhou, Yan; Han, Hongwei et al. · 2021 · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · DOI

Full title: Myofibroblast fate plasticity in tissue repair and fibrosis: Deactivation, apoptosis, senescence and reprogramming.

Authors: Merkt, Wolfgang; Zhou, Yan; Han, Hongwei; Lagares, David

Year: 2021

Venue: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

DOI: https://doi.org/10.1111/wrr.12952

Paper Signals of stress

Gemma K. Alderton · 2021 · Science · DOI

Full title: Signals of stress

Authors: Gemma K. Alderton

Year: 2021

Venue: Science

DOI: https://doi.org/10.1126/science.372.6542.585-d

Paper Abstract 331: Clearance Of Senescent Cells Reduces Osteogenic And Fibrogenic Signaling In Fibrocalcific Aortic Valve Stenosis

Luisa F. Leon-Sanchez; Carolyn M. Roos; Michael A. Hagler et al. · 2023 · Arteriosclerosis, Thrombosis and Vascular Biology · DOI

Full title: Abstract 331: Clearance Of Senescent Cells Reduces Osteogenic And Fibrogenic Signaling In Fibrocalcific Aortic Valve Stenosis

Authors: Luisa F. Leon-Sanchez; Carolyn M. Roos; Michael A. Hagler; Runqing Huang; Bin Zhang; Eduardo Posada; James Kirkland; Tamar Tchkonia; Jordan D. Miller

Year: 2023

Venue: Arteriosclerosis, Thrombosis and Vascular Biology

DOI: https://doi.org/10.1161/atvb.43.suppl_1.331

Paper Research Progress of Senolytic Drugs in the Treatment of Orthopedic Diseases.

Zhang, Minjie; Lou, Pengqiang; Shou, Dan et al. · 2025 · Gerontology · DOI

Full title: Research Progress of Senolytic Drugs in the Treatment of Orthopedic Diseases.

Authors: Zhang, Minjie; Lou, Pengqiang; Shou, Dan; Tong, Peijian; Zhang, Yang

Year: 2025

Venue: Gerontology

DOI: https://doi.org/10.1159/000543386

Paper Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease

Donato, Anthony J.; Machin, Daniel R.; Lesniewski, Lisa A. · 2018 · Circulation Research · DOI

Full title: Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease

Authors: Donato, Anthony J.; Machin, Daniel R.; Lesniewski, Lisa A.

Year: 2018

Venue: Circulation Research

DOI: https://doi.org/10.1161/circresaha.118.312563

Paper Quercetin and Osteoarthritis: A Mechanistic Review on the Present Documents

Samadi, Faezeh; Kahrizi, Mohammad Saeed; Deravi, Niloofar et al. · 2022 · Pharmacology · DOI

Full title: Quercetin and Osteoarthritis: A Mechanistic Review on the Present Documents

Authors: Samadi, Faezeh; Kahrizi, Mohammad Saeed; Deravi, Niloofar; Arefnezhad, Reza; Roghani‐Shahraki, Hossein; Ardekani, Abnoos Mokhtari; Rezaei‐Tazangi, Fatemeh

Year: 2022

Venue: Pharmacology

DOI: https://doi.org/10.1159/000525494

Paper Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression

E. Born; L. Lipskaia; M. Breau et al. · 2022 · Circulation · DOI

Full title: Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression

Authors: E. Born; L. Lipskaia; M. Breau; Amal Houssaini; D. Beaulieu; E. Marcos; R. Pierre; Marcio Do Cruzeiro; M. Lefevre; G. Derumeaux; D. Bulavin; M. Delcroix; R. Quarck; Virinder Reen; Jesús Gil; D. Bernard; J. Flaman; S. Adnot; S. Abid

Year: 2022

Venue: Circulation

DOI: https://doi.org/10.1161/circulationaha.122.058794

Paper Abstract P162: Senolytic Treatment Attenuates Palmitic Acid-Induced Microglial Activation: Therapeutic Implications for Obesity-Induced Sympathoexcitation

Bhuvana Plakkot; Chenoa Turtle; M. Subramanian · 2024 · HYPERTENSION · DOI

Full title: Abstract P162: Senolytic Treatment Attenuates Palmitic Acid-Induced Microglial Activation: Therapeutic Implications for Obesity-Induced Sympathoexcitation

Authors: Bhuvana Plakkot; Chenoa Turtle; M. Subramanian

Year: 2024

Venue: HYPERTENSION

DOI: https://doi.org/10.1161/hyp.81.suppl_1.p162

Paper Renovascular Disease Induces Senescence in Renal Scattered Tubular-Like Cells and Impairs Their reparative Potency.

Xiao-Jun Chen; Seo Rin Kim; Kai Jiang et al. · 2021 · HYPERTENSION · DOI

Full title: Renovascular Disease Induces Senescence in Renal Scattered Tubular-Like Cells and Impairs Their reparative Potency.

Authors: Xiao-Jun Chen; Seo Rin Kim; Kai Jiang; Christopher M. Ferguson; Hui Tang; Xiang-Yang Zhu; A. Lerman; A. Eirin; L. Lerman

Year: 2021

Venue: HYPERTENSION

DOI: https://doi.org/10.1161/hypertensionaha.120.16218

Paper Endothelial Senescence: A New Age in Pulmonary Hypertension

Culley, Miranda K.; Chan, Stephen Y. · 2022 · Circulation Research · DOI

Full title: Endothelial Senescence: A New Age in Pulmonary Hypertension

Authors: Culley, Miranda K.; Chan, Stephen Y.

Year: 2022

Venue: Circulation Research

DOI: https://doi.org/10.1161/circresaha.121.319815

Paper Abstract WP224: Pharmacological Clearance Of Senescent Cells Prevents Intracranial Aneurysm Rupture

Taichi Ishiguro; J. Ai; Hiroki Sato et al. · 2023 · Stroke · DOI

Full title: Abstract WP224: Pharmacological Clearance Of Senescent Cells Prevents Intracranial Aneurysm Rupture

Authors: Taichi Ishiguro; J. Ai; Hiroki Sato; M. Lawton; Satoru Eguchi; T. Hashimoto

Year: 2023

Venue: Stroke

DOI: https://doi.org/10.1161/str.54.suppl_1.wp224

Paper Abstract 14285: Sodium Glucose Co-Transporter 2 Inhibition Eliminates Senescent Cells Through Downregulation of PD-L1 and Improves Pathological Aging

G. Katsuumi; M. Suda; I. Shimizu et al. · 2023 · Circulation · DOI

Full title: Abstract 14285: Sodium Glucose Co-Transporter 2 Inhibition Eliminates Senescent Cells Through Downregulation of PD-L1 and Improves Pathological Aging

Authors: G. Katsuumi; M. Suda; I. Shimizu; Y. Yoshida; T. Furihata; Y. Joki; C. Hsiao; Tohru Minamino

Year: 2023

Venue: Circulation

DOI: https://doi.org/10.1161/circ.148.suppl_1.14285

Paper Abstract 4364300: The Senolytic Navitoclax (ABT263) Reduces Coronary Atherosclerosis and Upregulates Plaque Stability in Atherosclerotic Pigs

S. Sukhanov; Yusuke Higashi; S. Danchuk et al. · 2025 · Circulation · DOI

Full title: Abstract 4364300: The Senolytic Navitoclax (ABT263) Reduces Coronary Atherosclerosis and Upregulates Plaque Stability in Atherosclerotic Pigs

Authors: S. Sukhanov; Yusuke Higashi; S. Danchuk; C. Lott; Mingqiao Li; Noah Landry; Amy Scarborough; Eric Lazartigues; Zach Rozenbaum; James Jenkins; P. Delafontaine

Year: 2025

Venue: Circulation

DOI: https://doi.org/10.1161/circ.152.suppl_3.4364300

Paper Hyperoxia-induced Cellular Senescence in Fetal Airway Smooth Muscle Cells.

Parikh, Pavan; Britt, Rodney D; Manlove, Logan J et al. · 2019 · American journal of respiratory cell and molecular biology · DOI

Full title: Hyperoxia-induced Cellular Senescence in Fetal Airway Smooth Muscle Cells.

Authors: Parikh, Pavan; Britt, Rodney D; Manlove, Logan J; Wicher, Sarah A; Roesler, Anne; Ravix, Jovanka; Teske, Jacob; Thompson, Michael A; Sieck, Gary C; Kirkland, James L; LeBrasseur, Nathan; Tschumperlin, Daniel J; Pabelick, Christina M; Prakash, Y S

Year: 2019

Venue: American journal of respiratory cell and molecular biology

DOI: https://doi.org/10.1165/rcmb.2018-0176OC

Paper Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment

Zachary S. Clayton; Matthew J. Rossman; S. Mahoney et al. · 2023 · HYPERTENSION · DOI

Full title: Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment

Authors: Zachary S. Clayton; Matthew J. Rossman; S. Mahoney; Ravinandan Venkatasubramanian; Grace S Maurer; David A. Hutton; Nicholas S. VanDongen; Nathan T Greenberg; Abigail G. Longtine; Katelyn R. Ludwig; Vienna E. Brunt; T. LaRocca; J. Campisi; S. Melov; D. Seals

Year: 2023

Venue: HYPERTENSION

DOI: https://doi.org/10.1161/hypertensionaha.123.21392

Paper Evidence That SARS-CoV-2 Induces Lung Cell Senescence: Potential Impact on COVID-19 Lung Disease

L. Lipskaia; P. Maisonnasse; C. Fouillade et al. · 2021 · American Journal of Respiratory Cell and Molecular Biology · DOI

Full title: Evidence That SARS-CoV-2 Induces Lung Cell Senescence: Potential Impact on COVID-19 Lung Disease

Authors: L. Lipskaia; P. Maisonnasse; C. Fouillade; V. Sencio; Q. Pascal; J. Flaman; E. Born; A. Londoño-Vallejo; R. Le Grand; D. Bernard; F. Trottein; S. Adnot

Year: 2021

Venue: American Journal of Respiratory Cell and Molecular Biology

DOI: https://doi.org/10.1165/rcmb.2021-0205le

Paper Dasatinib Plus Quercetin Alleviates Choroid Neovascularization by Reducing the Cellular Senescence Burden in the RPE–Choroid

Yinhao Wang; Yu-Ling Tseng; Keyu Chen et al. · 2023 · Investigative Ophthalmology and Visual Science · DOI

Full title: Dasatinib Plus Quercetin Alleviates Choroid Neovascularization by Reducing the Cellular Senescence Burden in the RPE–Choroid

Authors: Yinhao Wang; Yu-Ling Tseng; Keyu Chen; Kuangqi Chen; Kai Chen; Zhihua Huang; Z. Mao; Xuemin Li

Year: 2023

Venue: Investigative Ophthalmology and Visual Science

DOI: https://doi.org/10.1167/iovs.64.12.39

Paper Old Cells in Young Airway Smooth Muscle: Does Neonatal Senescence Cause Lifelong Airway Obstruction?

Sarah K. Sasse; A. Gerber · 2019 · American Journal of Respiratory Cell and Molecular Biology · DOI

Full title: Old Cells in Young Airway Smooth Muscle: Does Neonatal Senescence Cause Lifelong Airway Obstruction?

Authors: Sarah K. Sasse; A. Gerber

Year: 2019

Venue: American Journal of Respiratory Cell and Molecular Biology

DOI: https://doi.org/10.1165/rcmb.2018-0399ed

Paper Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases.

Barnes, Peter J; Baker, Jonathan; Donnelly, Louise E · 2019 · American journal of respiratory and critical care medicine · DOI

Full title: Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases.

Authors: Barnes, Peter J; Baker, Jonathan; Donnelly, Louise E

Year: 2019

Venue: American journal of respiratory and critical care medicine

DOI: https://doi.org/10.1164/rccm.201810-1975TR

Paper Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress.

Venkatasubramanian, Ravinandan; Darrah, Mary A; Mahoney, Sophia A et al. · 2025 · Hypertension (Dallas, Tex. : 1979) · DOI

Full title: Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress.

Authors: Venkatasubramanian, Ravinandan; Darrah, Mary A; Mahoney, Sophia A; Hutton, David A; Maurer, Grace S; Ludwig, Katelyn R; Van Dongen, Nicholas S; Greenberg, Nathan T; Longtine, Abigail G; Brunt, Vienna E; Singh, Parminder; Galligan, James J; Trujillo, Marissa N; Kapahi, Pankaj; Melov, Simon; Rossman, Matthew J; Seals, Douglas R; Clayton, Zachary S

Year: 2025

Venue: Hypertension (Dallas, Tex. : 1979)

DOI: https://doi.org/10.1161/HYPERTENSIONAHA.125.25408

Paper The Achilles’ heel of cancer survivors: fundamentals of accelerated cellular senescence

Shafqat, Shameel; Chicas, Evelyn Arana; Shafqat, Areez et al. · 2022 · Journal of Clinical Investigation · DOI

Full title: The Achilles’ heel of cancer survivors: fundamentals of accelerated cellular senescence

Authors: Shafqat, Shameel; Chicas, Evelyn Arana; Shafqat, Areez; Hashmi, Shahrukh K.

Year: 2022

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci158452

Paper Biological aging processes underlying cognitive decline and neurodegenerative disease

Gonzales, Mitzi M.; Garbarino, Valentina R.; Pollet, Erin et al. · 2022 · Journal of Clinical Investigation · DOI

Full title: Biological aging processes underlying cognitive decline and neurodegenerative disease

Authors: Gonzales, Mitzi M.; Garbarino, Valentina R.; Pollet, Erin; Palavicini, Juan Pablo; Kellogg, Dean L.; Kraig, Ellen; Orr, Miranda E.

Year: 2022

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci158453

Paper Strategies targeting cellular senescence

Ovadya, Yossi; Krizhanovsky, Valery · 2018 · Journal of Clinical Investigation · DOI

Full title: Strategies targeting cellular senescence

Authors: Ovadya, Yossi; Krizhanovsky, Valery

Year: 2018

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci95149

Paper DPP4 inhibition impairs senohemostasis to improve plaque stability in atherosclerotic mice

Allison B Herman; Dimitrios Tsitsipatis; C. Anerillas et al. · 2023 · Journal of Clinical Investigation · DOI

Full title: DPP4 inhibition impairs senohemostasis to improve plaque stability in atherosclerotic mice

Authors: Allison B Herman; Dimitrios Tsitsipatis; C. Anerillas; K. Mazan-Mamczarz; Angelica E Carr; Jordan M. Gregg; Mingyi Wang; Jing Zhang; Marc Michel; Charnae’ Henry-Smith; Sophia C Harris; R. Munk; J. Martindale; Y. Piao; Jinshui Fan; J. Mattison; Supriyo De; K. Abdelmohsen; R. Maul; Toshiko Tanaka; A. Moore; Megan E. DeMouth; Simone Sidoli; L. Ferrucci; Yie Liu; R. de Cabo; E. Lakatta; M. Gorospe

Year: 2023

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci165933

Paper Drinking from the fountain of youth for mTOR-related epilepsy

Jennifer C. Wong · 2024 · Epilepsy Currents · DOI

Full title: Drinking from the fountain of youth for mTOR-related epilepsy

Authors: Jennifer C. Wong

Year: 2024

Venue: Epilepsy Currents

DOI: https://doi.org/10.1177/15357597241284103

Paper Advancing Alzheimer's disease treatment: A literature review on senolytic intervention

Victor C Onuh · 2025 · Journal of Alzheimer's Disease · DOI

Full title: Advancing Alzheimer's disease treatment: A literature review on senolytic intervention

Authors: Victor C Onuh

Year: 2025

Venue: Journal of Alzheimer's Disease

DOI: https://doi.org/10.1177/13872877251376540

Paper Ginsenosides C-Mc1 and C-O Unique to Wild Ginseng: Novel Senotherapeutic Agents to Regulate Cellular Senescence

Dohyun Kim; Seong-Kyu Kang; Seung-Hyun Jun et al. · 2025 · Natural Product Communications · DOI

Full title: Ginsenosides C-Mc1 and C-O Unique to Wild Ginseng: Novel Senotherapeutic Agents to Regulate Cellular Senescence

Authors: Dohyun Kim; Seong-Kyu Kang; Seung-Hyun Jun; Nae-Gyu Kang

Year: 2025

Venue: Natural Product Communications

DOI: https://doi.org/10.1177/1934578x251338519

Paper Poster 125: Determining Biological Age and Prolonging the Healthspan by Targeting Senescence

Kelsey M O'Hara; M. Mullen; Verena Oberlohr et al. · 2022 · Orthopaedic Journal of Sports Medicine · DOI

Full title: Poster 125: Determining Biological Age and Prolonging the Healthspan by Targeting Senescence

Authors: Kelsey M O'Hara; M. Mullen; Verena Oberlohr; Sealy Hambright; J. Huard; Victoria R. Duke

Year: 2022

Venue: Orthopaedic Journal of Sports Medicine

DOI: https://doi.org/10.1177/2325967121s00686

Paper Advancements in therapeutic drugs targeting of senescence

Mingsheng Zhu; P. Meng; Xian Ling et al. · 2020 · Therapeutic Advances in Chronic Disease · DOI

Full title: Advancements in therapeutic drugs targeting of senescence

Authors: Mingsheng Zhu; P. Meng; Xian Ling; Lili Zhou

Year: 2020

Venue: Therapeutic Advances in Chronic Disease

DOI: https://doi.org/10.1177/2040622320964125

Paper A Review of Recent Innovations in Cartilage Regeneration Strategies for the Treatment of Primary Osteoarthritis of the Knee: Intra-articular Injections

Nicholas A. Householder; Akshay Raghuram; K. Agyare et al. · 2023 · Orthopaedic Journal of Sports Medicine · DOI

Full title: A Review of Recent Innovations in Cartilage Regeneration Strategies for the Treatment of Primary Osteoarthritis of the Knee: Intra-articular Injections

Authors: Nicholas A. Householder; Akshay Raghuram; K. Agyare; Skyler Thipaphay; M. Zumwalt

Year: 2023

Venue: Orthopaedic Journal of Sports Medicine

DOI: https://doi.org/10.1177/23259671231155950

Paper Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo.

Lehmann, Mareike; Korfei, Martina; Mutze, Kathrin et al. · 2017 · The European respiratory journal · DOI

Full title: Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo.

Authors: Lehmann, Mareike; Korfei, Martina; Mutze, Kathrin; Klee, Stephan; Skronska-Wasek, Wioletta; Alsafadi, Hani N; Ota, Chiharu; Costa, Rita; Schiller, Herbert B; Lindner, Michael; Wagner, Darcy E; Günther, Andreas; Königshoff, Melanie

Year: 2017

Venue: The European respiratory journal

DOI: https://doi.org/10.1183/13993003.02367-2016

Paper Acute Myeloid Leukemia Induces an Increased Senescent Phenotype in the Large Intestine Which Protects Barrier Function and Reduces Leakiness

Katherine Hampton; A. Polski-Delve; Rebecca S. Maynard et al. · 2024 · Blood · DOI

Full title: Acute Myeloid Leukemia Induces an Increased Senescent Phenotype in the Large Intestine Which Protects Barrier Function and Reduces Leakiness

Authors: Katherine Hampton; A. Polski-Delve; Rebecca S. Maynard; Kristian Bowles; N. Beraza; S. Rushworth

Year: 2024

Venue: Blood

DOI: https://doi.org/10.1182/blood-2024-209897

Paper Therapy Induced Senescence Is Associated with a Myeloid Gene Signature in Multiple Myeloma Plasma Cells

A. Guilatco; Marta Diaz-delCastillo; Gabriel Alvares Borges et al. · 2024 · Blood · DOI

Full title: Therapy Induced Senescence Is Associated with a Myeloid Gene Signature in Multiple Myeloma Plasma Cells

Authors: A. Guilatco; Marta Diaz-delCastillo; Gabriel Alvares Borges; Christine M. Hachfeld; Neal I. Sannuli; M. Ritting; Syed Mohammed Musheer Aalam; Nagarajan Kannan; Tamar Tchkonia; James L. Kirkland; T. Kourelis; Matthew T. Drake; Yi Lin; T. Andersen; Megan M. Weivoda

Year: 2024

Venue: Blood

DOI: https://doi.org/10.1182/blood-2024-211757

Paper B-Precursor Acute Lymphoblastic Leukaemia Causes Paracrine Senescence in Mesenchymal Stromal Cells to Subvert the Treatment Response in Adult Acute Lymphoblastic Leukaemia

Aditi Dey; Ruchi Kumari; A. Innes et al. · 2024 · Blood · DOI

Full title: B-Precursor Acute Lymphoblastic Leukaemia Causes Paracrine Senescence in Mesenchymal Stromal Cells to Subvert the Treatment Response in Adult Acute Lymphoblastic Leukaemia

Authors: Aditi Dey; Ruchi Kumari; A. Innes; E. Cutler; Hermione Allen; Jenny Chatzigerou; Rodothea Amerikanou; Juma Ward; Jesús Gil; Adele K. Fielding; Kristina Kirschner

Year: 2024

Venue: Blood

DOI: https://doi.org/10.1182/blood-2024-205756

Paper Targeting BRD4 to reshape the inflammatory microenvironment of senescent bone marrow mesenchymal stem cells for improved hematopoietic stem cell transplantation reconstitution

Cong Wang; Chengyan Chai; Zheng Wang et al. · 2025 · Blood · DOI

Full title: Targeting BRD4 to reshape the inflammatory microenvironment of senescent bone marrow mesenchymal stem cells for improved hematopoietic stem cell transplantation reconstitution

Authors: Cong Wang; Chengyan Chai; Zheng Wang; Xi Zhang

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood-2025-3184

Paper Targeting BCL-XL and BCL-2 By Protac 753B Effectively Eliminates AML Cells and Enhances Efficacy of Chemotherapy By Targeting Senescent Cells

Yannan Jia; Qi Zhang; Weiguo Zhang et al. · 2021 · Blood · DOI

Full title: Targeting BCL-XL and BCL-2 By Protac 753B Effectively Eliminates AML Cells and Enhances Efficacy of Chemotherapy By Targeting Senescent Cells

Authors: Yannan Jia; Qi Zhang; Weiguo Zhang; M. Andreeff; N. Jain; Peiyi Zhang; Guangrong Zheng; Daohong Zhou; M. Konopleva

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood-2021-147535

Paper Remission instead of eradication? MEK inhibition in primary refractory childhood LCH

Alexander Desuki; C. Paret; Ina Oehme et al. · 2025 · Blood · DOI

Full title: Remission instead of eradication? MEK inhibition in primary refractory childhood LCH

Authors: Alexander Desuki; C. Paret; Ina Oehme; H. Peterziel; Olaf Witt; Francesca Alt; Olaf Beck; Khalifa ElMalki; A. Wingerter; Julia Heider; Achim Reckmann; G. Staatz; Thomas Lehrnbecher; J. Faber; M. Minkov; Alexandra Russo

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood-2025-7281

Paper Therapy-induced senescence reprograms non-M3 AML into a drug-exploitable APL-like state

Martin Schönlein; W. Walter; Paulina Richter-Pechanska et al. · 2025 · Blood · DOI

Full title: Therapy-induced senescence reprograms non-M3 AML into a drug-exploitable APL-like state

Authors: Martin Schönlein; W. Walter; Paulina Richter-Pechanska; Katharina Barbara Rösel; Diego Gilioli; Zhiting Shao; J. Ihlow; Karsten Spiekermann; Katharina S. S. Götze; Soyoung Lee; Yong Yu; T. Haferlach; Hugues de Thé; R. Di Micco; Clemens A. Schmitt

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood-2025-3244

Paper Long-Term Clearance of Senescent Cells Prevents the Hematopoietic Stem Cell Aging in Naturally Aged Mice

Yonghan He; Jianhui Chang; D. Lv et al. · 2019 · Blood · DOI

Full title: Long-Term Clearance of Senescent Cells Prevents the Hematopoietic Stem Cell Aging in Naturally Aged Mice

Authors: Yonghan He; Jianhui Chang; D. Lv; Ha-Neui Kim; Maria Almeida; Xin Zhang; Xinjian Mao; Xinghui Zhao; Linheng Li; J. Campisi; Ying Liang; Daohong Zhou

Year: 2019

Venue: Blood

DOI: https://doi.org/10.1182/blood-2019-123159

Paper Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

Zalpoor, Hamidreza; Nabi‐Afjadi, Mohsen; Forghaniesfidvajani, Razieh et al. · 2022 · Cellular & Molecular Biology Letters · DOI

Full title: Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

Authors: Zalpoor, Hamidreza; Nabi‐Afjadi, Mohsen; Forghaniesfidvajani, Razieh; Tavakol, Chanour; Farahighasreaboonasr, Faranak; Pakizeh, Farid; Dana, Vahid Ghobadi; Seif, Farhad

Year: 2022

Venue: Cellular & Molecular Biology Letters

DOI: https://doi.org/10.1186/s11658-022-00355-3

Paper SARS-CoV-2-induced senescence as a potential therapeutic target

Denholm, Mary; Rintoul, Robert C.; Muñoz‐Espín, Daniel · 2022 · European Respiratory Journal · DOI

Full title: SARS-CoV-2-induced senescence as a potential therapeutic target

Authors: Denholm, Mary; Rintoul, Robert C.; Muñoz‐Espín, Daniel

Year: 2022

Venue: European Respiratory Journal

DOI: https://doi.org/10.1183/13993003.01101-2022

Paper Late Breaking Abstract - Evaluating the feasibility, safety, and efficacy of senolytics in idiopathic pulmonary fibrosis

A. Nambiar; J. Justice; T. Tchkonia et al. · 2019 · Idiopathic interstitial pneumonias · DOI

Full title: Late Breaking Abstract - Evaluating the feasibility, safety, and efficacy of senolytics in idiopathic pulmonary fibrosis

Authors: A. Nambiar; J. Justice; T. Tchkonia; N. LeBrasseur; R. Pascual; S. Hashmi; L. Prata; M. Masternak; N. Musi; S. Kritchevsky; J. Kirkland

Year: 2019

Venue: Idiopathic interstitial pneumonias

DOI: https://doi.org/10.1183/13993003.congress-2019.oa244

Paper Mitochondrial antiviral signaling protein is crucial for the development of pulmonary fibrosis

Kim, Sang‐Hun; Lee, Jung Yeon; Yoon, Chang Min et al. · 2020 · European Respiratory Journal · DOI

Full title: Mitochondrial antiviral signaling protein is crucial for the development of pulmonary fibrosis

Authors: Kim, Sang‐Hun; Lee, Jung Yeon; Yoon, Chang Min; Shin, Hyeon Jun; Lee, Sei Won; Rosas, Iván O.; Herzog, Erica L.; Cruz, Charles S. Dela; Kaminski, Naftali; Kang, Min‐Jong

Year: 2020

Venue: European Respiratory Journal

DOI: https://doi.org/10.1183/13993003.00652-2020

Paper Lung regeneration: implications of the diseased niche and ageing

Melo-Narváez, M. Camila; Stegmayr, John; Wagner, Darcy E. et al. · 2020 · European Respiratory Review · DOI

Full title: Lung regeneration: implications of the diseased niche and ageing

Authors: Melo-Narváez, M. Camila; Stegmayr, John; Wagner, Darcy E.; Lehmann, Mareike

Year: 2020

Venue: European Respiratory Review

DOI: https://doi.org/10.1183/16000617.0222-2020

Paper The tyrosine kinase inhibitor Dasatinib reduces cardiac steatosis and fibrosis in obese, type 2 diabetic mice

Gu, Yue; Avolio, Elisa; Alvino, Valeria Vincenza et al. · 2023 · Cardiovascular Diabetology · DOI

Full title: The tyrosine kinase inhibitor Dasatinib reduces cardiac steatosis and fibrosis in obese, type 2 diabetic mice

Authors: Gu, Yue; Avolio, Elisa; Alvino, Valeria Vincenza; Thomas, Anita C.; Herman, Andrew; Miller, P. J.; Sullivan, Niall; Faulkner, Ashton; Madeddu, Paolo

Year: 2023

Venue: Cardiovascular Diabetology

DOI: https://doi.org/10.1186/s12933-023-01955-9

Paper Senogenic-senolytic treatment strategies enhance tumor control and can improve survival in murine cancer models: a systematic review.

Eleane C B Hamburger; P. Brigato; Derek H. Rosenzweig et al. · 2026 · BMC Cancer · DOI

Full title: Senogenic-senolytic treatment strategies enhance tumor control and can improve survival in murine cancer models: a systematic review.

Authors: Eleane C B Hamburger; P. Brigato; Derek H. Rosenzweig; Lisbet Haglund

Year: 2026

Venue: BMC Cancer

DOI: https://doi.org/10.1186/s12885-026-15650-x

Paper Shared mechanisms of multimorbidity in COPD, atherosclerosis and type-2 diabetes: the neutrophil as a potential inflammatory target

Hughes, Michael; McGettrick, Helen M.; Sapey, Elizabeth · 2020 · European Respiratory Review · DOI

Full title: Shared mechanisms of multimorbidity in COPD, atherosclerosis and type-2 diabetes: the neutrophil as a potential inflammatory target

Authors: Hughes, Michael; McGettrick, Helen M.; Sapey, Elizabeth

Year: 2020

Venue: European Respiratory Review

DOI: https://doi.org/10.1183/16000617.0102-2019

Paper Skin senescence: mechanisms and impact on whole-body aging

Franco, Ana Catarina; Aveleira, Célia A.; Cavadas, Cláudia · 2022 · Trends in Molecular Medicine · DOI

Full title: Skin senescence: mechanisms and impact on whole-body aging

Authors: Franco, Ana Catarina; Aveleira, Célia A.; Cavadas, Cláudia

Year: 2022

Venue: Trends in Molecular Medicine

DOI: https://doi.org/10.1016/j.molmed.2021.12.003

Paper The use of geroprotectors to prevent multimorbidity: opportunities and challenges.

Samir Morsli; I. Bellantuono · 2020 · Mechanisms of Ageing and Development · DOI

Full title: The use of geroprotectors to prevent multimorbidity: opportunities and challenges.

Authors: Samir Morsli; I. Bellantuono

Year: 2020

Venue: Mechanisms of Ageing and Development

DOI: https://doi.org/10.1016/j.mad.2020.111391

Paper Senotherapy for chronic lung disease.

Barnes, Peter J · 2025 · Pharmacological reviews · DOI

Full title: Senotherapy for chronic lung disease.

Authors: Barnes, Peter J

Year: 2025

Venue: Pharmacological reviews

DOI: https://doi.org/10.1016/j.pharmr.2025.100069

Paper Development of new non-viral systems for genetic modification of senescent cells

López-Seijas, Junquera; Miranda-Balbuena, Diego; Iglesias-Fente, Alba et al. · 2023 · Molecular Therapy — Nucleic Acids · DOI

Full title: Development of new non-viral systems for genetic modification of senescent cells

Authors: López-Seijas, Junquera; Miranda-Balbuena, Diego; Iglesias-Fente, Alba; Sacristán-Santos, Marta; Carballo-Pedrares, Natalia; Arufe, María C.; Rey‐Rico, Ana; Fafián‐Labora, Juan

Year: 2023

Venue: Molecular Therapy — Nucleic Acids

DOI: https://doi.org/10.1016/j.omtn.2023.03.010

Paper Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy model.

Yao, Minmin; Wei, Zhiliang; Nielsen, Jonathan Scharff et al. · 2024 · Neurobiology of disease · DOI

Full title: Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy model.

Year: 2024

Venue: Neurobiology of disease

DOI: https://doi.org/10.1016/j.nbd.2024.106711

Paper Senescent brain cell types in Alzheimer's disease: Pathological mechanisms and therapeutic opportunities.

Hudson, Hannah R; Sun, Xuehan; Orr, Miranda E · 2025 · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · DOI

Full title: Senescent brain cell types in Alzheimer's disease: Pathological mechanisms and therapeutic opportunities.

Authors: Hudson, Hannah R; Sun, Xuehan; Orr, Miranda E

Year: 2025

Venue: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

DOI: https://doi.org/10.1016/j.neurot.2024.e00519

Paper Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders

Tábatha de Oliveira Silva; Guilherme Lunardon; C. Lino et al. · 2024 · Molecular Metabolism · DOI

Full title: Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders

Authors: Tábatha de Oliveira Silva; Guilherme Lunardon; C. Lino; Amanda de Almeida Silva; Shiju Zhang; Maria Cláudia Costa Irigoyen; Y. Lu; J. Mably; M. Barreto-Chaves; Da-Zhi Wang; G. Diniz

Year: 2024

Venue: Molecular Metabolism

DOI: https://doi.org/10.1016/j.molmet.2024.102065

Paper Therapy-induced senescence through the redox lens.

Robert, Matius; Kennedy, Brian K; Crasta, Karen C · 2024 · Redox biology · DOI

Full title: Therapy-induced senescence through the redox lens.

Authors: Robert, Matius; Kennedy, Brian K; Crasta, Karen C

Year: 2024

Venue: Redox biology

DOI: https://doi.org/10.1016/j.redox.2024.103228

Paper Evaluation of exploratory fluid biomarkers from a phase 1 senolytic trial in mild Alzheimer's disease.

Garbarino, Valentina R; Palavicini, Juan Pablo; Melendez, Justin et al. · 2025 · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · DOI

Full title: Evaluation of exploratory fluid biomarkers from a phase 1 senolytic trial in mild Alzheimer's disease.

Authors: Garbarino, Valentina R; Palavicini, Juan Pablo; Melendez, Justin; Barthelemy, Nicolas R; He, Yingxin; Kautz, Tiffany F; Lopez-Cruzan, Marisa; Mathews, Julia J; Xu, Peng; Zhang, Bin; Saliba, Afaf; Ragi, Nagarjunachary; Sharma, Kumar; Mason, Dallin; Johnson, Samuel; Hendrix, Suzanne; Craft, Suzanne; Petersen, Ronald C; Espindola-Netto, Jair Machado; Xue, Ailing; Tchkonia, Tamara; Kirkland, James L; Salardini, Arash; Musi, Nicolas; Bateman, Randall J; Gonzales, Mitzi M; Orr, Miranda E

Year: 2025

Venue: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

DOI: https://doi.org/10.1016/j.neurot.2025.e00591

Paper Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice

Lérida‐Viso, Araceli; Estepa‐Fernández, Alejandra; Morellá‐Aucejo, Ángela et al. · 2022 · Pharmacological Research · DOI

Full title: Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice

Authors: Lérida‐Viso, Araceli; Estepa‐Fernández, Alejandra; Morellá‐Aucejo, Ángela; Lozano‐Torres, Beatriz; Alfonso, María; Blandez, Juan F.; Bisbal, Viviana; Sepúlveda, Pilar; García‐Fernández, Alba; Orzáez, Mar; Martínez‐Máñez, Ramón

Year: 2022

Venue: Pharmacological Research

DOI: https://doi.org/10.1016/j.phrs.2022.106356

Paper Senescence-mediated anticancer effects of quercetin.

Özsoy Gökbilen, Serpil; Becer, Eda; Vatansever, Hafize Seda · 2022 · Nutrition research (New York, N.Y.) · DOI

Full title: Senescence-mediated anticancer effects of quercetin.

Authors: Özsoy Gökbilen, Serpil; Becer, Eda; Vatansever, Hafize Seda

Year: 2022

Venue: Nutrition research (New York, N.Y.)

DOI: https://doi.org/10.1016/j.nutres.2022.04.007

Paper New frontier for epilepsy treatment through targeting cellular senescence.

Bello, Stephen Temitayo; Rafe, Md Rajdoula; Huang, Fengwen · 2025 · Progress in neuro-psychopharmacology & biological psychiatry · DOI

Full title: New frontier for epilepsy treatment through targeting cellular senescence.

Authors: Bello, Stephen Temitayo; Rafe, Md Rajdoula; Huang, Fengwen

Year: 2025

Venue: Progress in neuro-psychopharmacology & biological psychiatry

DOI: https://doi.org/10.1016/j.pnpbp.2025.111506

Paper Biological functions of therapy-induced senescence in cancer.

Fitsiou, Eleni; Soto-Gamez, Abel; Demaria, Marco · 2022 · Seminars in cancer biology · DOI

Full title: Biological functions of therapy-induced senescence in cancer.

Authors: Fitsiou, Eleni; Soto-Gamez, Abel; Demaria, Marco

Year: 2022

Venue: Seminars in cancer biology

DOI: https://doi.org/10.1016/j.semcancer.2021.03.021

Paper Time for the systems-level integration of aging: Resilience enhancing strategies to prevent Alzheimer’s disease

Hampel, Harald; Lista, Simone; Néri, Christian et al. · 2019 · Progress in Neurobiology · DOI

Full title: Time for the systems-level integration of aging: Resilience enhancing strategies to prevent Alzheimer’s disease

Authors: Hampel, Harald; Lista, Simone; Néri, Christian; Vergallo, Andrea

Year: 2019

Venue: Progress in Neurobiology

DOI: https://doi.org/10.1016/j.pneurobio.2019.101662

Paper Morusin targets DNA methyltransferase 1 to trigger senescence and sensitizes colorectal cancer to senolytic therapy.

Yang, Peng; Kong, Juanjuan; Li, Xuejia et al. · 2026 · Phytomedicine : international journal of phytotherapy and phytopharmacology · DOI

Full title: Morusin targets DNA methyltransferase 1 to trigger senescence and sensitizes colorectal cancer to senolytic therapy.

Authors: Yang, Peng; Kong, Juanjuan; Li, Xuejia; Lu, Yu; Liang, Gang; Yu, Baofeng; Wang, Hailong; Fu, Rong

Year: 2026

Venue: Phytomedicine : international journal of phytotherapy and phytopharmacology

DOI: https://doi.org/10.1016/j.phymed.2026.157812

Paper Senescent cell clearance by the immune system: Emerging therapeutic opportunities.

L. Prata; I. Ovsyannikova; T. Tchkonia et al. · 2018 · Seminars in Immunology · DOI

Full title: Senescent cell clearance by the immune system: Emerging therapeutic opportunities.

Authors: L. Prata; I. Ovsyannikova; T. Tchkonia; J. Kirkland

Year: 2018

Venue: Seminars in Immunology

DOI: https://doi.org/10.1016/j.smim.2019.04.003

Paper MiR-34b promotes oxidative stress and induces cellular senescence through TWIST1 in human cervical cancer.

Sindhu, K J; Nalini, Venkatesan; Suraishkumar, G K et al. · 2024 · Translational oncology · DOI

Full title: MiR-34b promotes oxidative stress and induces cellular senescence through TWIST1 in human cervical cancer.

Authors: Sindhu, K J; Nalini, Venkatesan; Suraishkumar, G K; Karunagaran, Devarajan

Year: 2024

Venue: Translational oncology

DOI: https://doi.org/10.1016/j.tranon.2024.102063

Paper Targeting senescent cells to reshape the tumor microenvironment and improve anticancer efficacy.

Jiang, Birong; Zhang, Wei; Zhang, Xuguang et al. · 2024 · Seminars in cancer biology · DOI

Full title: Targeting senescent cells to reshape the tumor microenvironment and improve anticancer efficacy.

Authors: Jiang, Birong; Zhang, Wei; Zhang, Xuguang; Sun, Yu

Year: 2024

Venue: Seminars in cancer biology

DOI: https://doi.org/10.1016/j.semcancer.2024.05.002

Paper The redox-senescence axis and its therapeutic targeting.

Ngoi, Natalie Yl; Liew, Angeline Qx; Chong, Stephen J F et al. · 2021 · Redox biology · DOI

Full title: The redox-senescence axis and its therapeutic targeting.

Authors: Ngoi, Natalie Yl; Liew, Angeline Qx; Chong, Stephen J F; Davids, Matthew S; Clement, Marie-Veronique; Pervaiz, Shazib

Year: 2021

Venue: Redox biology

DOI: https://doi.org/10.1016/j.redox.2021.102032

Paper Senotherapeutics: Targeting senescence in idiopathic pulmonary fibrosis.

Merkt, Wolfgang; Bueno, Marta; Mora, Ana L et al. · 2020 · Seminars in cell & developmental biology · DOI

Full title: Senotherapeutics: Targeting senescence in idiopathic pulmonary fibrosis.

Authors: Merkt, Wolfgang; Bueno, Marta; Mora, Ana L; Lagares, David

Year: 2020

Venue: Seminars in cell & developmental biology

DOI: https://doi.org/10.1016/j.semcdb.2019.12.008

Paper Gestational arsenite exposure augments hepatic tumors of C3H mice by promoting senescence in F1 and F2 offspring via different pathways.

Okamura, Kazuyuki; Suzuki, Takehiro; Nohara, Keiko · 2020 · Toxicology and applied pharmacology · DOI

Full title: Gestational arsenite exposure augments hepatic tumors of C3H mice by promoting senescence in F1 and F2 offspring via different pathways.

Authors: Okamura, Kazuyuki; Suzuki, Takehiro; Nohara, Keiko

Year: 2020

Venue: Toxicology and applied pharmacology

DOI: https://doi.org/10.1016/j.taap.2020.115259

Paper Peptide-Amphiphilic Nanoassemblies as a Responsive Senolytic Navigator for Targeted Removal of Senescent Cardiomyocytes to Ameliorate Heart Failure.

Zhiye Wu; Yinghua Zeng; Huiming Chen et al. · 2024 · ACS Applied Materials and Interfaces · DOI

Full title: Peptide-Amphiphilic Nanoassemblies as a Responsive Senolytic Navigator for Targeted Removal of Senescent Cardiomyocytes to Ameliorate Heart Failure.

Authors: Zhiye Wu; Yinghua Zeng; Huiming Chen; Zhengnan Xiao; Jingbin Guo; Mohamed Nor Abubakar; Mingzhi Shen; Hua Xiao; Xudong Song; Yanbin Cai

Year: 2024

Venue: ACS Applied Materials and Interfaces

DOI: https://doi.org/10.1021/acsami.4c09734

Paper Nanodevice-Mediated Immune Cell Recruitment: Targeting Senescent Cells via MMP-3-Responsive CXCL12-Coated Nanoparticles.

Blanca Escriche-Navarro; Eva Garrido; Sandra Clara-Trujillo et al. · 2025 · ACS Applied Materials and Interfaces · DOI

Full title: Nanodevice-Mediated Immune Cell Recruitment: Targeting Senescent Cells via MMP-3-Responsive CXCL12-Coated Nanoparticles.

Authors: Blanca Escriche-Navarro; Eva Garrido; Sandra Clara-Trujillo; Anna Labernadie; F. Sancenón; A. García‐Fernández; R. Martínez‐Máñez

Year: 2025

Venue: ACS Applied Materials and Interfaces

DOI: https://doi.org/10.1021/acsami.4c17748

Paper Suppression of autophagy induces senescence in the heart.

Zhai, Peiyong; Sung, Eun-Ah; Shiheido-Watanabe, Yuka et al. · 2024 · Journal of molecular and cellular cardiology · DOI

Full title: Suppression of autophagy induces senescence in the heart.

Authors: Zhai, Peiyong; Sung, Eun-Ah; Shiheido-Watanabe, Yuka; Takayama, Koichiro; Tian, Yimin; Sadoshima, Junichi

Year: 2024

Venue: Journal of molecular and cellular cardiology

DOI: https://doi.org/10.1016/j.yjmcc.2024.08.001

Paper Prospective Selective Mechanism of Emerging Senolytic Agents Derived from Flavonoids.

Wang, Yijun; He, Yufeng; Rayman, Margaret P et al. · 2021 · Journal of agricultural and food chemistry · DOI

Full title: Prospective Selective Mechanism of Emerging Senolytic Agents Derived from Flavonoids.

Authors: Wang, Yijun; He, Yufeng; Rayman, Margaret P; Zhang, Jinsong

Year: 2021

Venue: Journal of agricultural and food chemistry

DOI: https://doi.org/10.1021/acs.jafc.1c04379

Paper Design and Synthesis of Senescence-Targeted Prodrugs with Senomorphic and Senolytic Properties To Mitigate Chemotherapy-Induced Kidney Injury.

Lele Ding; Xi Wang; Qian Liu et al. · 2025 · Journal of Medicinal Chemistry · DOI

Full title: Design and Synthesis of Senescence-Targeted Prodrugs with Senomorphic and Senolytic Properties To Mitigate Chemotherapy-Induced Kidney Injury.

Authors: Lele Ding; Xi Wang; Qian Liu; Yuxuan Zhang; Xinyu Wu; Biying Xiao; Dan Liu; Lu Chen; Hairong Zeng; Bei Zhao; Changsheng Dong; Lihui Li; Guangbo Ge; Lijun Jia; Shuaishuai Ni

Year: 2025

Venue: Journal of Medicinal Chemistry

DOI: https://doi.org/10.1021/acs.jmedchem.5c01442

Paper Targeted Supramolecular Senolytics by Enzyme-Responsive Disassembly and Intracellular Polymerization.

Sangpil Kim; Jaeeun Lee; Yumi Cho et al. · 2026 · ACS Applied Materials and Interfaces · DOI

Full title: Targeted Supramolecular Senolytics by Enzyme-Responsive Disassembly and Intracellular Polymerization.

Authors: Sangpil Kim; Jaeeun Lee; Yumi Cho; Hyun-Seo Park; Seung Hak Oh; Jiye Kim; Dohyun Kim; Youjung Sim; Min-Seok Seu; Chaekyu Kim; Sang Kyu Kwak; Ja-Hyoung Ryu

Year: 2026

Venue: ACS Applied Materials and Interfaces

DOI: https://doi.org/10.1021/acsami.5c18350

Paper Design of a Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells

Wnuk, Maciej; Sol‐Fernández, Susel Del; Błoniarz, Dominika et al. · 2024 · ACS Biomaterials Science & Engineering · DOI

Full title: Design of a Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells

Authors: Wnuk, Maciej; Sol‐Fernández, Susel Del; Błoniarz, Dominika; Słaby, Julia; Szmatoła, Tomasz; Żebrowski, Michał; Martínez‐Vicente, Pablo; Litwinienko, Grzegorz; Moros, María; Lewińska, Anna

Year: 2024

Venue: ACS Biomaterials Science & Engineering

DOI: https://doi.org/10.1021/acsbiomaterials.4c00771

Paper Disrupting the Senescence-Associated Secretory Phenotype-M1Macrophage Feedback Loop in Synovitis Using Dual Nano-Switches To Restore Joint Homeostasis.

Jing Zhang; Xinghua Li; Ping Wang et al. · 2026 · ACS Nano · DOI

Full title: Disrupting the Senescence-Associated Secretory Phenotype-M1Macrophage Feedback Loop in Synovitis Using Dual Nano-Switches To Restore Joint Homeostasis.

Authors: Jing Zhang; Xinghua Li; Ping Wang; Xin Liu; Wuqi Guo; Jia Si; Qiang Huo; Ming Xu; Yang Liu; Yimin Niu

Year: 2026

Venue: ACS Nano

DOI: https://doi.org/10.1021/acsnano.5c15543

Paper Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Ok-hee Jeon; Chaekyun Kim; Rémi-Martin Laberge et al. · 2017 · Nature Medicine · DOI

Full title: Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Authors: Ok-hee Jeon; Chaekyun Kim; Rémi-Martin Laberge; M. Demaria; Sona Rathod; A. Vasserot; Jae Wook Chung; Do Hun Kim; Yan Poon; Nathaniel David; D. Baker; J. V. van Deursen; J. Campisi; J. Elisseeff

Year: 2017

Venue: Nature Medicine

DOI: https://doi.org/10.1038/nm.4324

Paper Bone: Targeting old cells to protect old bones

Joanna Collison · 2017 · Nature Reviews Rheumatology · DOI

Full title: Bone: Targeting old cells to protect old bones

Authors: Joanna Collison

Year: 2017

Venue: Nature Reviews Rheumatology

DOI: https://doi.org/10.1038/nrrheum.2017.152

Paper Targeting cellular senescence prevents age-related bone loss in mice.

Farr, Joshua N; Xu, Ming; Weivoda, Megan M et al. · 2017 · Nature medicine · DOI

Full title: Targeting cellular senescence prevents age-related bone loss in mice.

Authors: Farr, Joshua N; Xu, Ming; Weivoda, Megan M; Monroe, David G; Fraser, Daniel G; Onken, Jennifer L; Negley, Brittany A; Sfeir, Jad G; Ogrodnik, Mikolaj B; Hachfeld, Christine M; LeBrasseur, Nathan K; Drake, Matthew T; Pignolo, Robert J; Pirtskhalava, Tamar; Tchkonia, Tamara; Oursler, Merry Jo; Kirkland, James L; Khosla, Sundeep

Year: 2017

Venue: Nature medicine

DOI: https://doi.org/10.1038/nm.4385

Paper Senotherapeutics for healthy ageing

L. Niedernhofer; P. Robbins · 2018 · Nature reviews. Drug discovery · DOI

Full title: Senotherapeutics for healthy ageing

Authors: L. Niedernhofer; P. Robbins

Year: 2018

Venue: Nature reviews. Drug discovery

DOI: https://doi.org/10.1038/nrd.2018.44

Paper Endothelial senescence in vascular diseases: current understanding and future opportunities in senotherapeutics

Han, Yeaeun; Kim, Sung Young · 2023 · Experimental & Molecular Medicine · DOI

Full title: Endothelial senescence in vascular diseases: current understanding and future opportunities in senotherapeutics

Authors: Han, Yeaeun; Kim, Sung Young

Year: 2023

Venue: Experimental & Molecular Medicine

DOI: https://doi.org/10.1038/s12276-022-00906-w

Paper Mapping the Progression of Therapy-Induced Senescence to Therapy Tolerance: An Evolutionarily Conserved Mechanism for Optimizing Cancer Treatment with Senotherapeutics.

Gargi Mukherjee; Neha Dutta; Muthumeena Ramanathan et al. · 2025 · ACS Pharmacology & Translational Science · DOI

Full title: Mapping the Progression of Therapy-Induced Senescence to Therapy Tolerance: An Evolutionarily Conserved Mechanism for Optimizing Cancer Treatment with Senotherapeutics.

Authors: Gargi Mukherjee; Neha Dutta; Muthumeena Ramanathan; Kankonika Bhattacharyya; Alabhya Das; Shaista Haider; Goutam Chowdhury; Anindita Chakrabarty

Year: 2025

Venue: ACS Pharmacology & Translational Science

DOI: https://doi.org/10.1021/acsptsci.5c00374

Paper Senescence as a therapeutically relevant response to CDK4/6 inhibitors

Verena Wagner; J. Gil · 2020 · Oncogene · DOI

Full title: Senescence as a therapeutically relevant response to CDK4/6 inhibitors

Authors: Verena Wagner; J. Gil

Year: 2020

Venue: Oncogene

DOI: https://doi.org/10.1038/s41388-020-1354-9

Paper Regulation of ribosomal gene expression and senescence by a PML-mTOR-RONIN nuclear complex in triple-negative breast cancer.

Medkour, Younes; Dufour, Catherine Rosa; Han, Lingwei et al. · 2025 · Oncogene · DOI

Full title: Regulation of ribosomal gene expression and senescence by a PML-mTOR-RONIN nuclear complex in triple-negative breast cancer.

Authors: Medkour, Younes; Dufour, Catherine Rosa; Han, Lingwei; Hutton, Phillipe; Farhat, Mirna; Alfonso, Anthony; Rambur, Amandine; Vernier, Mathieu; Giguère, Vincent

Year: 2025

Venue: Oncogene

DOI: https://doi.org/10.1038/s41388-025-03623-6

Paper Cellular senescence in neuroblastoma

Zanotti, Sofia; Decaesteker, Bieke; Vanhauwaert, Suzanne et al. · 2022 · British Journal of Cancer · DOI

Full title: Cellular senescence in neuroblastoma

Authors: Zanotti, Sofia; Decaesteker, Bieke; Vanhauwaert, Suzanne; Wilde, Bram De; Vos, Winnok H. De; Speleman, Frank

Year: 2022

Venue: British Journal of Cancer

DOI: https://doi.org/10.1038/s41416-022-01755-0

Paper BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer

Ashkan Shahbandi; Sonia G. Rao; Ashlyn Y. Anderson et al. · 2020 · Cell Death and Differentiation · DOI

Full title: BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer

Authors: Ashkan Shahbandi; Sonia G. Rao; Ashlyn Y. Anderson; Wesley D. Frey; J. O. Olayiwola; Nathan Ungerleider; J. Jackson

Year: 2020

Venue: Cell Death and Differentiation

DOI: https://doi.org/10.1038/s41418-020-0564-6

Paper Apoptotic priming in senescence predicts specific senolysis by quantitative analysis of mitochondrial dependencies.

MacDonald, Julie A; Bradshaw, Gary A; Jochems, Fleur et al. · 2025 · Cell death and differentiation · DOI

Full title: Apoptotic priming in senescence predicts specific senolysis by quantitative analysis of mitochondrial dependencies.

Authors: MacDonald, Julie A; Bradshaw, Gary A; Jochems, Fleur; Bernards, René; Letai, Anthony

Year: 2025

Venue: Cell death and differentiation

DOI: https://doi.org/10.1038/s41418-024-01431-1

Paper Promoting healthy cardiovascular aging: emerging topics

Clayton, Zachary S.; Craighead, Daniel H.; Darvish, Sanna et al. · 2022 · The Journal of Cardiovascular Aging · DOI

Full title: Promoting healthy cardiovascular aging: emerging topics

Authors: Clayton, Zachary S.; Craighead, Daniel H.; Darvish, Sanna; Coppock, McKinley E.; Ludwig, Katelyn R.; Brunt, Vienna E.; Seals, Douglas R.; Rossman, Matthew J.

Year: 2022

Venue: The Journal of Cardiovascular Aging

DOI: https://doi.org/10.20517/jca.2022.27

Paper Interconnections between Inflammageing and Immunosenescence During Ageing

Teissier, Thibault; Boulanger, Éric; Cox, Lynne S. · 2021 · Preprints.org · DOI

Full title: Interconnections between Inflammageing and Immunosenescence During Ageing

Authors: Teissier, Thibault; Boulanger, Éric; Cox, Lynne S.

Year: 2021

Venue: Preprints.org

DOI: https://doi.org/10.20944/preprints202110.0046.v1

Paper The Role of Nutraceuticals and Functional Foods in Mitigating Cellular Senescence and Its Related Aspects: A Key Strategy for Delaying or Preventing Aging and Neurodegenerative Disorders.

Ristori, Sara; Bertoni, Gianmarco; Bientinesi, Elisa et al. · 2025 · Nutrients · DOI

Full title: The Role of Nutraceuticals and Functional Foods in Mitigating Cellular Senescence and Its Related Aspects: A Key Strategy for Delaying or Preventing Aging and Neurodegenerative Disorders.

Authors: Ristori, Sara; Bertoni, Gianmarco; Bientinesi, Elisa; Monti, Daniela

Year: 2025

Venue: Nutrients

DOI: https://doi.org/10.3390/nu17111837

Paper Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease

Encina, María Camacho; Booth, Laura; Redgrave, Rachael E. et al. · 2024 · Cells · DOI

Full title: Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease

Authors: Encina, María Camacho; Booth, Laura; Redgrave, Rachael E.; Folaranmi, Omowumi; Spyridopoulos, Ioakim; Richardson, Gavin D.

Year: 2024

Venue: Cells

DOI: https://doi.org/10.3390/cells13040353

Paper Immunosenescence is a therapeutic target for frailty in older adults: a narrative review

Jia, Huanan; Huang, Wei; Liu, Chuanfeng et al. · 2022 · Annals of Translational Medicine · DOI

Full title: Immunosenescence is a therapeutic target for frailty in older adults: a narrative review

Authors: Jia, Huanan; Huang, Wei; Liu, Chuanfeng; Tang, Shiyu; Zhang, Jing; Chen, Chongli; Tian, Yuan; Zhong, Wen

Year: 2022

Venue: Annals of Translational Medicine

DOI: https://doi.org/10.21037/atm-22-4405

Paper The motor neuron disease mouse model hSOD1-G93A presents a non-canonical profile of senescence biomarkers in the spinal cord

P. Torres; C. Anerillas; M. Encinas et al. · 2020 · DOI

Full title: The motor neuron disease mouse model hSOD1-G93A presents a non-canonical profile of senescence biomarkers in the spinal cord

Authors: P. Torres; C. Anerillas; M. Encinas; M. Povedano; P. Andrés‐Benito; I. Ferrer; V. Ayala; R. Pamplona; M. Portero-Otín

Year: 2020

DOI: https://doi.org/10.21203/rs.3.rs-104871/v1

Paper Hedysarum multijugum Maxim treats ulcerative colitis through the PI3K-AKT and TNF signaling pathway according to network pharmacology and molecular docking

Zhang, Zihao; Chong, Wei; Xie, Xiaozhou et al. · 2022 · Annals of Translational Medicine · DOI

Full title: Hedysarum multijugum Maxim treats ulcerative colitis through the PI3K-AKT and TNF signaling pathway according to network pharmacology and molecular docking

Authors: Zhang, Zihao; Chong, Wei; Xie, Xiaozhou; Liu, Yuan; Liang, Shangdong; Li, Leping

Year: 2022

Venue: Annals of Translational Medicine

DOI: https://doi.org/10.21037/atm-22-4815

Paper Senolytic therapy to modulate the progression of Alzheimer's Disease (SToMP-AD) - Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease.

Gonzales, Mitzi M; Garbarino, Valentina R; Kautz, Tiffany et al. · 2023 · Research square · DOI

Full title: Senolytic therapy to modulate the progression of Alzheimer's Disease (SToMP-AD) - Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease.

Authors: Gonzales, Mitzi M; Garbarino, Valentina R; Kautz, Tiffany; Palavicini, Juan Pablo; Lopez-Cruzan, Marisa; Dehkordi, Shiva Kazempour; Mathews, Julia; Zare, Habil; Xu, Peng; Zhang, Bin; Franklin, Crystal; Habes, Mohamad; Craft, Suzanne; Petersen, Ronald C; Tchkonia, Tamara; Kirkland, James; Salardini, Arash; Seshadri, Sudha; Musi, Nicolas; Orr, Miranda E

Year: 2023

Venue: Research square

DOI: https://doi.org/10.21203/rs.3.rs-2809973/v1

Paper Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

Julio Aguado; Alberto A. Amarilla; Atefeh Taherian Fard et al. · 2023 · bioRxiv · DOI

Full title: Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

Year: 2023

Venue: bioRxiv

DOI: https://doi.org/10.21516/2072-0076-2025-18-4-169-177

Paper Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis

J. Delgado-Calle; Manish Adhikari; Japneet Kaur et al. · 2024 · Research Square · DOI

Full title: Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis

Authors: J. Delgado-Calle; Manish Adhikari; Japneet Kaur; H. Sabol; A. Anloague; Sharmin Khan; Noriyoshi Kurihara; Marta Diaz-delCastillo; C. Andreasen; C. L. Barnes; J. Stambough; Michela Palmieri; Olivia Reyes-Castro; E. Ambrogini; Maria Almeida; Charles O'Brien; I. Nookaew

Year: 2024

Venue: Research Square

DOI: https://doi.org/10.21203/rs.3.rs-4047486/v1

Paper Cellular Senescence and Senescence-Associated Secretory Phenotype Drive Multipotent Cardiac Stem/Progenitor Cell Dysfunction in Human Diabetic Cardiomyopathy Independently of Age

Fabiola Marino; Mariangela Scalise; D. Cappetta et al. · 2021 · Vascular pharmacology · DOI

Full title: Cellular Senescence and Senescence-Associated Secretory Phenotype Drive Multipotent Cardiac Stem/Progenitor Cell Dysfunction in Human Diabetic Cardiomyopathy Independently of Age

Authors: Fabiola Marino; Mariangela Scalise; D. Cappetta; Luca Salerno; C. Molinaro; N. Salerno; M. Torella; M. Greco; D. Foti; F. C. Sasso; P. Mastroroberto; A. De Angelis; G. Ellison‐Hughes; M. Rota; K. Urbanek; D. Torella; E. Cianflone

Year: 2021

Venue: Vascular pharmacology

DOI: https://doi.org/10.21203/rs.3.rs-607324/v1

Paper Molecular mechanisms of alveolar epithelial cell senescence and idiopathic pulmonary fibrosis: a narrative review.

Tu, Mingjin; Wei, Ting; Jia, Yufang et al. · 2023 · Journal of thoracic disease · DOI

Full title: Molecular mechanisms of alveolar epithelial cell senescence and idiopathic pulmonary fibrosis: a narrative review.

Authors: Tu, Mingjin; Wei, Ting; Jia, Yufang; Wang, Yajun; Wu, Jun

Year: 2023

Venue: Journal of thoracic disease

DOI: https://doi.org/10.21037/jtd-22-886

Paper Single-cell profiling of skeletal muscle reveals a novel senolytic target: CRYAB

Limbad, Chandani; Doi, Ryosuke; McGirr, Julia et al. · 2021 · Research Square (Research Square) · DOI

Full title: Single-cell profiling of skeletal muscle reveals a novel senolytic target: CRYAB

Authors: Limbad, Chandani; Doi, Ryosuke; McGirr, Julia; Ciotlos, Serban; Perez, Kevin; Daya, Radha; Campisi, Judith; Melov, Simon

Year: 2021

Venue: Research Square (Research Square)

DOI: https://doi.org/10.21203/rs.3.rs-456991/v1

Paper The Cancer Senescopedia – Delineation of Cancer Cell Senescence

F. Jochems; B. Thijssen; Robin Janssen et al. · 2021 · Social Science Research Network · DOI

Full title: The Cancer Senescopedia – Delineation of Cancer Cell Senescence

Authors: F. Jochems; B. Thijssen; Robin Janssen; G. Conti; Z. Pogacar; Liqin Wang; A. Schepers; Cun Wang; Haojie Jin; R. Beijersbergen; R. L. D. Oliveira; L. Wessels; R. Bernards

Year: 2021

Venue: Social Science Research Network

DOI: https://doi.org/10.2139/ssrn.3762763

Paper Targeted senolytic prodrug is well tolerated and results in amelioration of frailty, muscle regeneration and cognitive functions in geriatric mice

Doan, Linda; Paine, Patrick; Tran, Christopher et al. · 2020 · DOI

Full title: Targeted senolytic prodrug is well tolerated and results in amelioration of frailty, muscle regeneration and cognitive functions in geriatric mice

Authors: Doan, Linda; Paine, Patrick; Tran, Christopher; Parsons, Benjamin M.; Hiller, Amanda; Joshua, Isaac; Collaco, Nicholas; Vitari, Alberto; Morrée, Antoine de; Ishak, Heather D.; Jasper, Jeffrey; Gallop, Mark A.; Luo, Jian; Wyss‐Coray, Tony; Rando, Thomas A.; Quarta, Marco

Year: 2020

DOI: https://doi.org/10.21203/rs.3.rs-92962/v1

Paper A Transient Wave of Cellular Senescence is Required for Myofiber Growth and Myonuclear Accretion Following Injury

Laura V. Young; Alasdair Cameron; S. Springer et al. · 2020 · DOI

Full title: A Transient Wave of Cellular Senescence is Required for Myofiber Growth and Myonuclear Accretion Following Injury

Authors: Laura V. Young; Alasdair Cameron; S. Springer; J. Ross; Grant Wolters; J. Murphy; Michel G. Arsenault; Sean Y Ng; Vladimir Ljubicic; Adam P W Johnston

Year: 2020

DOI: https://doi.org/10.2139/ssrn.3748740

Paper Evaluation of Exploratory Fluid Biomarker Results from a Phase 1 Senolytic Trial in Mild Alzheimer’s Disease

M. Orr; V. Garbarino; J. Palavicini et al. · 2024 · Research Square · DOI

Full title: Evaluation of Exploratory Fluid Biomarker Results from a Phase 1 Senolytic Trial in Mild Alzheimer’s Disease

Authors: M. Orr; V. Garbarino; J. Palavicini; Justin Melendez; N. Barthélemy; Yingxin He; Tiffany F. Kautz; Marisa Lopez-Cruzan; Julia J. Mathews; Peng Xu; Bin Zhang; A. Saliba; N. Ragi; Kumar Sharma; Suzanne Craft; Ronald C. Petersen; J. Espindola-Netto; Ailing Xue; T. Tchkonia; James L. Kirkland; Sudha Seshadri; Arash Salardini; Nicolas Musi; Randall J. Bateman; Mitzi M. Gonzales

Year: 2024

Venue: Research Square

DOI: https://doi.org/10.21203/rs.3.rs-3994894/v1

Paper The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date

Oo, Win Min; Little, Christopher B.; Duong, Vicky et al. · 2021 · Drug Design Development and Therapy · DOI

Full title: The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date

Authors: Oo, Win Min; Little, Christopher B.; Duong, Vicky; Hunter, David J.

Year: 2021

Venue: Drug Design Development and Therapy

DOI: https://doi.org/10.2147/dddt.s295224

Paper Geroprotective technologies in the prevention and modifying treatment of age-associated retinal diseases

M. Zueva; V. Kotelin; N. Neroeva · 2026 · Russian Ophthalmological Journal · DOI

Full title: Geroprotective technologies in the prevention and modifying treatment of age-associated retinal diseases

Authors: M. Zueva; V. Kotelin; N. Neroeva

Year: 2026

Venue: Russian Ophthalmological Journal

Paper 296-LB: Loss of SERCA2 Induces Mitochondrial Dysfunction, Increases ß-Cell Senescence, and Accelerates Type 1 Diabetes Development

Staci A. Weaver; R. Bone; Dominic J. Acri et al. · 2023 · Diabetes · DOI

Full title: 296-LB: Loss of SERCA2 Induces Mitochondrial Dysfunction, Increases ß-Cell Senescence, and Accelerates Type 1 Diabetes Development

Authors: Staci A. Weaver; R. Bone; Dominic J. Acri; Jungsu Kim; T. Kono; R. Dahl; D. Eizirik; Farooq Syed; C. Evans-Molina

Year: 2023

Venue: Diabetes

DOI: https://doi.org/10.2337/db23-296-lb

Paper Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age.

Marino, Fabiola; Scalise, Mariangela; Salerno, Nadia et al. · 2022 · Diabetes · DOI

Full title: Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age.

Authors: Marino, Fabiola; Scalise, Mariangela; Salerno, Nadia; Salerno, Luca; Molinaro, Claudia; Cappetta, Donato; Torella, Michele; Greco, Marta; Foti, Daniela; Sasso, Ferdinando C; Mastroroberto, Pasquale; De Angelis, Antonella; Ellison-Hughes, Georgina M; Sampaolesi, Maurilio; Rota, Marcello; Rossi, Francesco; Urbanek, Konrad; Nadal-Ginard, Bernardo; Torella, Daniele; Cianflone, Eleonora

Year: 2022

Venue: Diabetes

DOI: https://doi.org/10.2337/db21-0536

Paper Novel therapeutic approaches to target neurodegeneration

Fuente, Alerie Guzman de la; Pelucchi, Silvia; Mertens, Jérôme et al. · 2023 · British Journal of Pharmacology · DOI

Full title: Novel therapeutic approaches to target neurodegeneration

Authors: Fuente, Alerie Guzman de la; Pelucchi, Silvia; Mertens, Jérôme; Luca, Mónica Di; Mauceri, Daniela; Marcello, Elena

Year: 2023

Venue: British Journal of Pharmacology

DOI: https://doi.org/10.1111/bph.16078

Paper Cellular Senescence and Senolytic Agents: Recent Updates on Their Role and Applications.

Chandrakar, Lokesh; Ambatwar, Ramesh; Khatik, Gopal L · 2024 · Current topics in medicinal chemistry · DOI

Full title: Cellular Senescence and Senolytic Agents: Recent Updates on Their Role and Applications.

Authors: Chandrakar, Lokesh; Ambatwar, Ramesh; Khatik, Gopal L

Year: 2024

Venue: Current topics in medicinal chemistry

DOI: https://doi.org/10.2174/0115680266273698231107110956

Paper Boosting NAD+ for Anti-Aging: Mechanisms, Interventions, and Opportunities

Alpay, Faruk · 2025 · DOI

Full title: Boosting NAD+ for Anti-Aging: Mechanisms, Interventions, and Opportunities

Authors: Alpay, Faruk

Year: 2025

DOI: https://doi.org/10.26434/chemrxiv-2025-nl80r

Paper Targeting our aging cells to treat metabolic disease

Jessica Bertschmann · 2018 · Health Science Inquiry · DOI

Full title: Targeting our aging cells to treat metabolic disease

Authors: Jessica Bertschmann

Year: 2018

Venue: Health Science Inquiry

DOI: https://doi.org/10.29173/hsi257

Paper Piperine: An Anticancer and Senostatic Drug

Lim, Jae Sung; Lee, Da Young; Lim, Ju Hyeon et al. · 2022 · Frontiers in Bioscience-Landmark · DOI

Full title: Piperine: An Anticancer and Senostatic Drug

Authors: Lim, Jae Sung; Lee, Da Young; Lim, Ju Hyeon; Oh, Won Keun; Park, Jun T.; Park, Sang Chul; Cho, Kyung A

Year: 2022

Venue: Frontiers in Bioscience-Landmark

DOI: https://doi.org/10.31083/j.fbl2704137

Paper Senolytic Drugs Attenuate Osteoarthritis-Related Articular Cartilage Degeneration: A Clinical Trial

· 2019 · Case Medical Research · DOI

Full title: Senolytic Drugs Attenuate Osteoarthritis-Related Articular Cartilage Degeneration: A Clinical Trial

Year: 2019

Venue: Case Medical Research

DOI: https://doi.org/10.31525/ct1-nct04210986

Paper Senolytics as drugs or fashionable dietary supplements

M. Starek; M. Dąbrowska; Paweł Gumułka · 2021 · DOI

Full title: Senolytics as drugs or fashionable dietary supplements

Authors: M. Starek; M. Dąbrowska; Paweł Gumułka

Year: 2021

DOI: https://doi.org/10.32383/farmpol/136334

Paper Targeting Cellular Senescence in Prostate Cancer: Molecular Landscape and Therapeutic Avenues

Haneen Hossam; Bandar Alattaibi · 2026 · annals of urologic oncology · DOI

Full title: Targeting Cellular Senescence in Prostate Cancer: Molecular Landscape and Therapeutic Avenues

Authors: Haneen Hossam; Bandar Alattaibi

Year: 2026

Venue: annals of urologic oncology

DOI: https://doi.org/10.32948/auo.2026.01.25

Paper Cellular aging and immunity

Zhelavskyi, M. M.; Kernychnyi, Serhii; Dmytriv, O. Ya. et al. · 2022 · Ukrainian Journal of Veterinary and Agricultural Sciences · DOI

Full title: Cellular aging and immunity

Authors: Zhelavskyi, M. M.; Kernychnyi, Serhii; Dmytriv, O. Ya.; Betlinska, T. V.

Year: 2022

Venue: Ukrainian Journal of Veterinary and Agricultural Sciences

DOI: https://doi.org/10.32718/ujvas5-1.02

Paper Mid-life: a critical window for intervention during aging

Carvalho, Eugénia · 2025 · DOI

Full title: Mid-life: a critical window for intervention during aging

Authors: Carvalho, Eugénia

Year: 2025

DOI: https://doi.org/10.32948/ajsep.2025.01.08

Paper Aging, Cellular Senescence and Diabetes Mellitus: Clinicopathological Correlates, Trends and Targets

Chrysanthus, Chukwuma Sr; Sr; Palmer, A et al. · 2019 · International Journal of Pharmacy and Infections Therapy · DOI

Full title: Aging, Cellular Senescence and Diabetes Mellitus: Clinicopathological Correlates, Trends and Targets

Authors: Chrysanthus, Chukwuma Sr; Sr; Palmer, A; Tchkonia, T; Lebrasseur, N; Chini, E; Xu, M; Kirkland, J; Herrera, M; Mingorance, C; Rodriguez-Rodriguez, R; Sotomayor, Alvarez De; M; Prattichizzo, F; Nigris, De; V; Sala, La; Procopio, L; Olivieri, A; Ceriello, F; A; Mchugh, D; Gil, J; Sr, Chukwuma; C; Wild, S; Roglic, G; Green, A; Sicree, A; King, H; Morley, J; Sr, Chukwuma; C; Palmer, A; Gustafson, B; Kirkland, J; Smith, U; Weir, S; Barinda, A; Ikeda, K; Nugrolo, D; Wardhana, D; Sasaki, N; Honda, S; Huy, H; Sing, H; Kim, M; Kim, W; Kakoki, M; Sullivan, K; Backus, C; Hayes, J; Oh, S; Hua, K; Li, N; Liu, F; Yang, P; Xiong, F; Yu, Q; Li, J; Crochemore, C; Molin, C; Montagne, B; Salles, A; Riachetti, M; Bilici, M; Arpaci, D; Ilikhan, S; Corakci, B; Bayraktaroglu, T; Arasli, M; Tekin, I; Salminen, A; Markowski, D; Thies, H; Guttlieb, A; Wenk, H; Wischnewsky, M; Bullerdiek, J; Rosso, A; Balsamo, A; Gambino, R; Dentelli, P; Falcioni, R; Cassader, M; Pegoraro, L; Sabbatinelli, J; Prattichizzo, F; Olivieri, F; Procapio, A; Rippo, M; Giuliani, A; Castro-Portuguez, R; Sutphin, G; Testa, R; Cerriello, A; Xiong, Y; Zhou, L; Sr, Chukwuma; C

Year: 2019

Venue: International Journal of Pharmacy and Infections Therapy

DOI: https://doi.org/10.31829/2765-852x/ijpit2019-2(1)-105

Paper - **DOI:** 10.32948/ajo.2024.12.25 - **Authors:** Q. Ain - **Year:** 2024 - **Journal:** Asia-Pacific Journal of Oncology

Q. Ain · 2024 · Asia-Pacific Journal of Oncology · DOI

Full title: - **DOI:** 10.32948/ajo.2024.12.25 - **Authors:** Q. Ain - **Year:** 2024 - **Journal:** Asia-Pacific Journal of Oncology

Authors: Q. Ain

Year: 2024

Venue: Asia-Pacific Journal of Oncology

DOI: https://doi.org/10.32948/ajo.2024.12.25

Paper Exploiting senescence as a therapeutic target in osteoarthritis

Christopher Larbie; Umar Raza · 2024 · Asia-Pacific Journal of Pharmacotherapy & Toxicology · DOI

Full title: Exploiting senescence as a therapeutic target in osteoarthritis

Authors: Christopher Larbie; Umar Raza

Year: 2024

Venue: Asia-Pacific Journal of Pharmacotherapy & Toxicology

DOI: https://doi.org/10.32948/ajpt.2024.11.19

Paper Senescence-Inflammatory Regulation of Reparative Cellular Reprogramming in Aging and Cancer

Menéndez, Javier A.; Alarcón, Tomás · 2017 · Frontiers in Cell and Developmental Biology · DOI

Full title: Senescence-Inflammatory Regulation of Reparative Cellular Reprogramming in Aging and Cancer

Authors: Menéndez, Javier A.; Alarcón, Tomás

Year: 2017

Venue: Frontiers in Cell and Developmental Biology

DOI: https://doi.org/10.3389/fcell.2017.00049

Paper An Appraisal on the Value of Using Nutraceutical Based Senolytics and Senostatics in Aging

Kaur, Amanpreet; Macip, Salvador; Stover, Cordula · 2020 · Frontiers in Cell and Developmental Biology · DOI

Full title: An Appraisal on the Value of Using Nutraceutical Based Senolytics and Senostatics in Aging

Authors: Kaur, Amanpreet; Macip, Salvador; Stover, Cordula

Year: 2020

Venue: Frontiers in Cell and Developmental Biology

DOI: https://doi.org/10.3389/fcell.2020.00218

Paper Src Tyrosine Kinase Inhibitors: New Perspectives on Their Immune, Antiviral, and Senotherapeutic Potential

Rivera, José; José, Esther San · 2019 · Frontiers in Pharmacology · DOI

Full title: Src Tyrosine Kinase Inhibitors: New Perspectives on Their Immune, Antiviral, and Senotherapeutic Potential

Authors: Rivera, José; José, Esther San

Year: 2019

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2019.01011

Paper Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis

Estornut, Cristina; Milara, Javier; Bayarri, María Amparo et al. · 2022 · Frontiers in Pharmacology · DOI

Full title: Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis

Authors: Estornut, Cristina; Milara, Javier; Bayarri, María Amparo; Belhadj, Nada; Cortijo, Julio

Year: 2022

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2021.794997

Paper Immunomodulatory Activity of Tyrosine Kinase Inhibitors to Elicit Cytotoxicity Against Cancer and Viral Infection

Climent, Núria; Plana, Montserrat · 2019 · Frontiers in Pharmacology · DOI

Full title: Immunomodulatory Activity of Tyrosine Kinase Inhibitors to Elicit Cytotoxicity Against Cancer and Viral Infection

Authors: Climent, Núria; Plana, Montserrat

Year: 2019

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2019.01232

Paper Application of Quercetin in the Treatment of Gastrointestinal Cancers

Mirazimi, Seyed Mohammad Ali; Dashti, Fatemeh; Tobeiha, Mohammad et al. · 2022 · Frontiers in Pharmacology · DOI

Full title: Application of Quercetin in the Treatment of Gastrointestinal Cancers

Authors: Mirazimi, Seyed Mohammad Ali; Dashti, Fatemeh; Tobeiha, Mohammad; Shahini, Ali; Jafari, Raha; Khoddami, Mehrad; Sheida, Amirhossein; EsnaAshari, Parastoo; Aflatoonian, Amir Hossein; Elikaii, Fateme; Zakeri, Melika Sadat; Hamblin, Michael R.; Aghajani, Mohammad; Bavarsadkarimi, Minoodokht; Mirzaei, Hamed

Year: 2022

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2022.860209

Paper Protective effect of quercetin on kidney diseases: From chemistry to herbal medicines

Chen, Yi-Qin; Chen, Hao-Yin; Tang, Qin-Qi et al. · 2022 · Frontiers in Pharmacology · DOI

Full title: Protective effect of quercetin on kidney diseases: From chemistry to herbal medicines

Authors: Chen, Yi-Qin; Chen, Hao-Yin; Tang, Qin-Qi; Li, Yifan; Liu, Xusheng; Lu, Fuhua; Gu, Yue-Yu

Year: 2022

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2022.968226

Paper Revisiting the neuroinflammation hypothesis in Alzheimer’s disease: a focus on the druggability of current targets

Wong-Guerra, Maylin; Calfío, Camila; Maccioni, Ricardo B. et al. · 2023 · Frontiers in Pharmacology · DOI

Full title: Revisiting the neuroinflammation hypothesis in Alzheimer’s disease: a focus on the druggability of current targets

Authors: Wong-Guerra, Maylin; Calfío, Camila; Maccioni, Ricardo B.; Rojo, Leonel E.

Year: 2023

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2023.1161850

Paper Pharmacological and mechanistic aspects of quercetin in osteoporosis

Deng, Tingting; Ding, Wenyu; Lu, Xi-Xue et al. · 2024 · Frontiers in Pharmacology · DOI

Full title: Pharmacological and mechanistic aspects of quercetin in osteoporosis

Authors: Deng, Tingting; Ding, Wenyu; Lu, Xi-Xue; Zhang, Qing‐Hao; Du, Jin-Xin; Wang, Lijuan; Yang, Meina; Yin, Ying; Liu, Fan-Jie

Year: 2024

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2024.1338951

Paper Aging, Immunity, and COVID-19: How Age Influences the Host Immune Response to Coronavirus Infections?

Bajaj, Varnica; Gadi, Nirupa; Spihlman, Allison P. et al. · 2021 · Frontiers in Physiology · DOI

Full title: Aging, Immunity, and COVID-19: How Age Influences the Host Immune Response to Coronavirus Infections?

Authors: Bajaj, Varnica; Gadi, Nirupa; Spihlman, Allison P.; Wu, Samantha; Choi, Christopher H.; Moulton, Vaishali R.

Year: 2021

Venue: Frontiers in Physiology

DOI: https://doi.org/10.3389/fphys.2020.571416

Paper Exploring the perspectives of pharmaceutical experts and healthcare practitioners on senolytic drugs for vascular aging-related disorder: a qualitative study

L. Wong; Haridah Alias; Kit Mun Tan et al. · 2023 · Frontiers in Pharmacology · DOI

Full title: Exploring the perspectives of pharmaceutical experts and healthcare practitioners on senolytic drugs for vascular aging-related disorder: a qualitative study

Authors: L. Wong; Haridah Alias; Kit Mun Tan; P. Wong; D. Murugan; Zhijian Hu; Yulan Lin

Year: 2023

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2023.1254470

Paper Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis

Vinatier, Claire; Domínguez, Eduardo; Guicheux, Jérôme et al. · 2018 · Frontiers in Physiology · DOI

Full title: Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis

Authors: Vinatier, Claire; Domínguez, Eduardo; Guicheux, Jérôme; Caramés, B.

Year: 2018

Venue: Frontiers in Physiology

DOI: https://doi.org/10.3389/fphys.2018.00706

Paper Patho-Physiology of Aging and Immune-Senescence: Possible Correlates With Comorbidity and Mortality in Middle-Aged and Old COVID-19 Patients

Farheen, Saba; Agrawal, Sudhanshu; Zubair, Swaleha et al. · 2021 · Frontiers in Aging · DOI

Full title: Patho-Physiology of Aging and Immune-Senescence: Possible Correlates With Comorbidity and Mortality in Middle-Aged and Old COVID-19 Patients

Authors: Farheen, Saba; Agrawal, Sudhanshu; Zubair, Swaleha; Agrawal, Anshu; Jamal, Fauzia; Altaf, Ishrat; Anwar, Abu Kashif; Umair, Syed Mohammad; Owais, Mohammad

Year: 2021

Venue: Frontiers in Aging

DOI: https://doi.org/10.3389/fragi.2021.748591

Paper Immune Senescence, Immunosenescence and Aging

Lee, Kyoo-a; Flores, Rafael R.; Jang, In Hwa et al. · 2022 · Frontiers in Aging · DOI

Full title: Immune Senescence, Immunosenescence and Aging

Authors: Lee, Kyoo-a; Flores, Rafael R.; Jang, In Hwa; Saathoff, Ashley M.; Robbins, Paul D.

Year: 2022

Venue: Frontiers in Aging

DOI: https://doi.org/10.3389/fragi.2022.900028

Paper Network Topology of Biological Aging and Geroscience-Guided Approaches to COVID-19

Landay, Alan; Bartley, Jenna M.; Banerjee, Dishary et al. · 2021 · Frontiers in Aging · DOI

Full title: Network Topology of Biological Aging and Geroscience-Guided Approaches to COVID-19

Authors: Landay, Alan; Bartley, Jenna M.; Banerjee, Dishary; Hargis, Geneva; Haynes, Laura; Keshavarzian, Ali; Kuo, Chia‐Ling; Kwon, Oh Sung; Li, Sheng; Li, Shuzhao; Oh, Julia; Özbolat, İbrahim T.; Ucar, Duygu; Xu, Ming; Yao, Xudong; Unutmaz, Derya; Kuchel, George A.

Year: 2021

Venue: Frontiers in Aging

DOI: https://doi.org/10.3389/fragi.2021.695218

Paper Role of Mitochondria in Retinal Pigment Epithelial Aging and Degeneration

Tong, Yao; Zhang, Zunyi; Wang, Shusheng · 2022 · Frontiers in Aging · DOI

Full title: Role of Mitochondria in Retinal Pigment Epithelial Aging and Degeneration

Authors: Tong, Yao; Zhang, Zunyi; Wang, Shusheng

Year: 2022

Venue: Frontiers in Aging

DOI: https://doi.org/10.3389/fragi.2022.926627

Paper Aging and oral squamous cell carcinoma development: the role of cellular senescence

S. Niklander; P. Aránguiz; F. Faunes et al. · 2023 · Frontiers in Oral Health · DOI

Full title: Aging and oral squamous cell carcinoma development: the role of cellular senescence

Authors: S. Niklander; P. Aránguiz; F. Faunes; R. Martínez-Flores

Year: 2023

Venue: Frontiers in Oral Health

DOI: https://doi.org/10.3389/froh.2023.1285276

Paper Geroscience and pathology: a new frontier in understanding age-related diseases

Fekete, Mónika; Major, Dávid; Fehér, Ágnes et al. · 2024 · Pathology & Oncology Research · DOI

Full title: Geroscience and pathology: a new frontier in understanding age-related diseases

Authors: Fekete, Mónika; Major, Dávid; Fehér, Ágnes; Fazekas‐Pongor, Vince; Lehoczki, Andrea

Year: 2024

Venue: Pathology & Oncology Research

DOI: https://doi.org/10.3389/pore.2024.1611623

Paper Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome

Mas‐Bargues, Cristina; Alique, Matilde; Barrús, María Teresa et al. · 2021 · Antioxidants · DOI

Full title: Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome

Authors: Mas‐Bargues, Cristina; Alique, Matilde; Barrús, María Teresa; Borrás, Consuelo; Rodrigues‐Díez, Raquel

Year: 2021

Venue: Antioxidants

DOI: https://doi.org/10.3390/antiox11010078

Paper Phytochemicals from Indian Ethnomedicines: Promising Prospects for the Management of Oxidative Stress and Cancer

Fatima, Nishat; Baqri, S. Shabihe Raza; Alsulimani, Ahmad et al. · 2021 · Antioxidants · DOI

Full title: Phytochemicals from Indian Ethnomedicines: Promising Prospects for the Management of Oxidative Stress and Cancer

Authors: Fatima, Nishat; Baqri, S. Shabihe Raza; Alsulimani, Ahmad; Fagoonee, Sharmila; Sláma, Petr; Kesari, Kavindra Kumar; Roychoudhury, Shubhadeep; Haque, Shafiul

Year: 2021

Venue: Antioxidants

DOI: https://doi.org/10.3390/antiox10101606

Paper Nephroprotective Effects of Synthetic Flavonoid Hidrosmin in Experimental Diabetic Nephropathy

Jiménez-Castilla, Luna; Marín‐Royo, Gema; Orejudo, Macarena et al. · 2021 · Antioxidants · DOI

Full title: Nephroprotective Effects of Synthetic Flavonoid Hidrosmin in Experimental Diabetic Nephropathy

Authors: Jiménez-Castilla, Luna; Marín‐Royo, Gema; Orejudo, Macarena; Opazo-Ríos, Lucas; Caro-Ordieres, Teresa; Artaiz, Inés; Suárez-Cortés, Tatiana; Zazpe, Arturo; Hernández, Gonzalo; Gómez‐Guerrero, Carmen; Egido, Jesús

Year: 2021

Venue: Antioxidants

DOI: https://doi.org/10.3390/antiox10121920

Paper Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease

Pedroza-Díaz, Johanna; Arroyave-Ospina, Johanna C.; Salas, Sandra Serna et al. · 2022 · Antioxidants · DOI

Full title: Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease

Authors: Pedroza-Díaz, Johanna; Arroyave-Ospina, Johanna C.; Salas, Sandra Serna; Moshage, Han

Year: 2022

Venue: Antioxidants

DOI: https://doi.org/10.3390/antiox11050975

Paper Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal Diseases

Mohtashami, Zahra; Singh, Mithalesh Kumar; Neto, Farid José Thomaz et al. · 2023 · Antioxidants · DOI

Full title: Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal Diseases

Authors: Mohtashami, Zahra; Singh, Mithalesh Kumar; Neto, Farid José Thomaz; Salimiaghdam, Nasim; Hasanpour, Hossein; Kenney, M. Cristina

Year: 2023

Venue: Antioxidants

DOI: https://doi.org/10.3390/antiox12020518

Paper A Fisetin Delivery System for Neuroprotection: A Co-Amorphous Dispersion Prepared in Supercritical Carbon Dioxide

Sip, Szymon; Rosiak, Natalia; Sip, Anna et al. · 2023 · Antioxidants · DOI

Full title: A Fisetin Delivery System for Neuroprotection: A Co-Amorphous Dispersion Prepared in Supercritical Carbon Dioxide

Authors: Sip, Szymon; Rosiak, Natalia; Sip, Anna; Żarowski, Marcin; Hojan, Katarzyna; Cielecka‐Piontek, Judyta

Year: 2023

Venue: Antioxidants

DOI: https://doi.org/10.3390/antiox13010024

Paper Effects of Fisetin Treatment on Cellular Senescence of Various Tissues and Organs of Old Sheep

Huard, Charles; Gao, Xueqin; Hazra, Maria E. Dey et al. · 2023 · Antioxidants · DOI

Full title: Effects of Fisetin Treatment on Cellular Senescence of Various Tissues and Organs of Old Sheep

Authors: Huard, Charles; Gao, Xueqin; Hazra, Maria E. Dey; Hazra, Rony-Orijit Dey; Lebsock, Kimberly; Easley, Jeremiah T.; Millett, Peter J.; Huard, Johnny

Year: 2023

Venue: Antioxidants

DOI: https://doi.org/10.3390/antiox12081646

Paper Vutiglabridin Alleviates Cellular Senescence with Metabolic Regulation and Circadian Clock in Human Dermal Fibroblasts

Heo, Jin-Woong; Lee, H.; Lee, Jimin et al. · 2024 · Antioxidants · DOI

Full title: Vutiglabridin Alleviates Cellular Senescence with Metabolic Regulation and Circadian Clock in Human Dermal Fibroblasts

Authors: Heo, Jin-Woong; Lee, H.; Lee, Jimin; Choi, Leo Sungwong; Shin, Jaejin; Mun, Ji-Young; Park, Hyung Soon; Park, Sang-Chul; Nam, Chang-Hoon

Year: 2024

Venue: Antioxidants

DOI: https://doi.org/10.3390/antiox13010109

Paper Cigarette Smoke-Induced Respiratory Response: Insights into Cellular Processes and Biomarkers

Cha, Sang-Ryul; Jang, Jimin; Park, Sung‐Min et al. · 2023 · Antioxidants · DOI

Full title: Cigarette Smoke-Induced Respiratory Response: Insights into Cellular Processes and Biomarkers

Authors: Cha, Sang-Ryul; Jang, Jimin; Park, Sung‐Min; Ryu, Se Min; Cho, Seong-Joon; Yang, Se‐Ran

Year: 2023

Venue: Antioxidants

DOI: https://doi.org/10.3390/antiox12061210

Paper Red Ginseng Attenuates the Hepatic Cellular Senescence in Aged Mice

Lee, Da‐Yeon; Arndt, Juliana; O’Connell, Jennifer et al. · 2024 · Biology · DOI

Full title: Red Ginseng Attenuates the Hepatic Cellular Senescence in Aged Mice

Authors: Lee, Da‐Yeon; Arndt, Juliana; O’Connell, Jennifer; Egan, Josephine M.; Kim, Yoo

Year: 2024

Venue: Biology

DOI: https://doi.org/10.3390/biology13010036

Paper Translating Senotherapeutic Interventions into the Clinic with Emerging Proteomic Technologies.

Dey, Amit K; Banarjee, Reema; Boroumand, Mozhgan et al. · 2023 · Biology · DOI

Full title: Translating Senotherapeutic Interventions into the Clinic with Emerging Proteomic Technologies.

Authors: Dey, Amit K; Banarjee, Reema; Boroumand, Mozhgan; Rutherford, Delaney V; Strassheim, Quinn; Nyunt, Thedoe; Olinger, Bradley; Basisty, Nathan

Year: 2023

Venue: Biology

DOI: https://doi.org/10.3390/biology12101301

Paper Mechanisms of Senescence and Anti-Senescence Strategies in the Skin

Konstantinou, Evangelia; Longange, Eliane; Kaya, Gürkan · 2024 · Biology · DOI

Full title: Mechanisms of Senescence and Anti-Senescence Strategies in the Skin

Authors: Konstantinou, Evangelia; Longange, Eliane; Kaya, Gürkan

Year: 2024

Venue: Biology

DOI: https://doi.org/10.3390/biology13090647

Paper Targeting Aging and Diseases Associated with Ferroptosis and Senescence Through Modulation of Iron, Oxidative Stress and Lipid Peroxidation

Malamati Kourti; G. Kontoghiorghes · 2025 · Antioxidants · DOI

Full title: Targeting Aging and Diseases Associated with Ferroptosis and Senescence Through Modulation of Iron, Oxidative Stress and Lipid Peroxidation

Authors: Malamati Kourti; G. Kontoghiorghes

Year: 2025

Venue: Antioxidants

DOI: https://doi.org/10.3390/antiox15010015

Paper Iron Metabolism in Cancer and Senescence: A Cellular Perspective

Crescenzi, Elvira; Leonardi, Antonio; Pacifico, Francesco · 2023 · Biology · DOI

Full title: Iron Metabolism in Cancer and Senescence: A Cellular Perspective

Authors: Crescenzi, Elvira; Leonardi, Antonio; Pacifico, Francesco

Year: 2023

Venue: Biology

DOI: https://doi.org/10.3390/biology12070989

Paper Oxidative Stress-Driven Cellular Senescence: Mechanistic Crosstalk and Therapeutic Horizons

Bojan Stojanović; Ivan P Jovanović; Milica Dimitrijevic Stojanovic et al. · 2025 · Antioxidants · DOI

Full title: Oxidative Stress-Driven Cellular Senescence: Mechanistic Crosstalk and Therapeutic Horizons

Authors: Bojan Stojanović; Ivan P Jovanović; Milica Dimitrijevic Stojanovic; Bojan Stojanović; Vojin Kovacevic; Ivan Radosavljevic; Danijela Jovanovic; Marina Miletić Kovačević; Nenad Zornić; Ana Azanjac Arsic; Stevan Eric; Nikola Mirković; Jelena Nešić; Stefan Jakovljević; Snjezana M Lazarevic; Ivana Milivojcevic Bevc; B. Milosevic

Year: 2025

Venue: Antioxidants

DOI: https://doi.org/10.3390/antiox14080987

Paper Tissue-Specific Landscape of Metabolic Dysregulation during Ageing

Zhang, Fangrong; Kerbl-Knapp, Jakob; Akhmetshina, Alena et al. · 2021 · Biomolecules · DOI

Full title: Tissue-Specific Landscape of Metabolic Dysregulation during Ageing

Authors: Zhang, Fangrong; Kerbl-Knapp, Jakob; Akhmetshina, Alena; Korbelius, Melanie; Kuentzel, Katharina B.; Vujić, Nemanja; Hörl, Gerd; Paar, Margret; Kratky, Dagmar; Steyrer, Ernst; Madl, Tobias

Year: 2021

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom11020235

Paper Aging and Mesenchymal Stem Cells: Basic Concepts, Challenges and Strategies.

Fraile, Maria; Eiro, Noemi; Costa, Luis A et al. · 2022 · Biology · DOI

Full title: Aging and Mesenchymal Stem Cells: Basic Concepts, Challenges and Strategies.

Authors: Fraile, Maria; Eiro, Noemi; Costa, Luis A; Martín, Arancha; Vizoso, Francisco J

Year: 2022

Venue: Biology

DOI: https://doi.org/10.3390/biology11111678

Paper p19Arf Exacerbates Cigarette Smoke-Induced Pulmonary Dysfunction

Mikawa, Ryuta; Sato, Tadashi; Suzuki, Yohei et al. · 2020 · Biomolecules · DOI

Full title: p19Arf Exacerbates Cigarette Smoke-Induced Pulmonary Dysfunction

Authors: Mikawa, Ryuta; Sato, Tadashi; Suzuki, Yohei; Baskoro, Hario; Kawaguchi, Koichiro; Sugimoto, Masataka

Year: 2020

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom10030462

Paper Novel Targets and Therapeutic Strategies for Promoting Organ Repair and Regeneration

Muruganandan, Shanmugam; Wigerius, Michael · 2020 · Biomolecules · DOI

Full title: Novel Targets and Therapeutic Strategies for Promoting Organ Repair and Regeneration

Authors: Muruganandan, Shanmugam; Wigerius, Michael

Year: 2020

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom10050749

Paper Therapeutic Potential of a Senolytic Approach in a Murine Model of Chronic GVHD

Deepika Raman; C. Chêne; C. Nicco et al. · 2023 · Biology · DOI

Full title: Therapeutic Potential of a Senolytic Approach in a Murine Model of Chronic GVHD

Authors: Deepika Raman; C. Chêne; C. Nicco; M. Jeljeli; J. Eu; M. Clément; F. Batteux; S. Pervaiz

Year: 2023

Venue: Biology

DOI: https://doi.org/10.3390/biology12050647

Paper New Insights into the Role of Cellular Senescence and Its Therapeutic Implications in Ocular Diseases.

Wu, Junying; Liu, Xiuxing; Liu, Yidan et al. · 2025 · Bioengineering (Basel, Switzerland) · DOI

Full title: New Insights into the Role of Cellular Senescence and Its Therapeutic Implications in Ocular Diseases.

Authors: Wu, Junying; Liu, Xiuxing; Liu, Yidan; Su, Wenru; Zhuo, Yehong

Year: 2025

Venue: Bioengineering (Basel, Switzerland)

DOI: https://doi.org/10.3390/bioengineering12060563

Paper Role of Senescent Cells in Cutaneous Wound Healing

Andrade, Allison M.; Sun, Mingda; Gasek, Nathan et al. · 2022 · Biology · DOI

Full title: Role of Senescent Cells in Cutaneous Wound Healing

Authors: Andrade, Allison M.; Sun, Mingda; Gasek, Nathan; Hargis, Geneva; Sharafieh, Roshanak; Xu, Ming

Year: 2022

Venue: Biology

DOI: https://doi.org/10.3390/biology11121731

Paper Selective Targeting of Senescent FHs74Int Cells by Human Breast Milk Free Fatty Acids.

Tremblay, Tony; Loubaki, Lionel · 2025 · Biology · DOI

Full title: Selective Targeting of Senescent FHs74Int Cells by Human Breast Milk Free Fatty Acids.

Authors: Tremblay, Tony; Loubaki, Lionel

Year: 2025

Venue: Biology

DOI: https://doi.org/10.3390/biology14101355

Paper The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases.

Cuollo, Lorenzo; Antonangeli, Fabrizio; Santoni, Angela et al. · 2020 · Biology · DOI

Full title: The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases.

Authors: Cuollo, Lorenzo; Antonangeli, Fabrizio; Santoni, Angela; Soriani, Alessandra

Year: 2020

Venue: Biology

DOI: https://doi.org/10.3390/biology9120485

Paper Targeting of BCL-2 Family Members during Anticancer Treatment: A Necessary Compromise between Individual Cell and Ecosystemic Responses?

Barillé‐Nion, Sophie; Lohard, Steven; Juin, Philippe · 2020 · Biomolecules · DOI

Full title: Targeting of BCL-2 Family Members during Anticancer Treatment: A Necessary Compromise between Individual Cell and Ecosystemic Responses?

Authors: Barillé‐Nion, Sophie; Lohard, Steven; Juin, Philippe

Year: 2020

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom10081109

Paper Is Senolytic Therapy in Cardiovascular Diseases Ready for Translation to Clinics?

Yang, Zhihong; Potenza, Duilio Michele; Ming, Xiu‐Fen · 2025 · Biomolecules · DOI

Full title: Is Senolytic Therapy in Cardiovascular Diseases Ready for Translation to Clinics?

Authors: Yang, Zhihong; Potenza, Duilio Michele; Ming, Xiu‐Fen

Year: 2025

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom15040545

Paper Counteracting Immunosenescence-Which Therapeutic Strategies Are Promising?

Hieber, Christoph; Grabbe, Stephan; Bros, Matthias · 2023 · Biomolecules · DOI

Full title: Counteracting Immunosenescence-Which Therapeutic Strategies Are Promising?

Authors: Hieber, Christoph; Grabbe, Stephan; Bros, Matthias

Year: 2023

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom13071085

Paper Cellular Senescence in Intervertebral Disc Aging and Degeneration: Molecular Mechanisms and Potential Therapeutic Opportunities.

Silwal, Prashanta; Nguyen-Thai, Allison M; Mohammad, Haneef Ahamed et al. · 2023 · Biomolecules · DOI

Full title: Cellular Senescence in Intervertebral Disc Aging and Degeneration: Molecular Mechanisms and Potential Therapeutic Opportunities.

Authors: Silwal, Prashanta; Nguyen-Thai, Allison M; Mohammad, Haneef Ahamed; Wang, Yanshan; Robbins, Paul D; Lee, Joon Y; Vo, Nam V

Year: 2023

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom13040686

Paper The Role of Autophagy in Osteoarthritic Cartilage

Kao, Wei‐Chun; Chen, Jian‐Chih; Liu, Ping‐Cheng et al. · 2022 · Biomolecules · DOI

Full title: The Role of Autophagy in Osteoarthritic Cartilage

Authors: Kao, Wei‐Chun; Chen, Jian‐Chih; Liu, Ping‐Cheng; Lu, Cheng‐Chang; Lin, Sung‐Yen; Chuang, Shu‐Chun; Wu, Shun‐Cheng; Chang, Ling-Hua; Lee, Mon‐Juan; Yang, Chung‐Da; Lee, Tien‐Ching; Wang, Yingchun; Li, Jhong-You; Wei, Chun‐Wang; Chen, Chung‐Hwan

Year: 2022

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom12101357

Paper Novel Nutraceutical Compounds in Alzheimer Prevention

Maccioni, Ricardo B.; Calfío, Camila; González, Andrea et al. · 2022 · Biomolecules · DOI

Full title: Novel Nutraceutical Compounds in Alzheimer Prevention

Authors: Maccioni, Ricardo B.; Calfío, Camila; González, Andrea; Lüttges, Valentina

Year: 2022

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom12020249

Paper Cell Senescence in Heterotopic Ossification.

Pignolo, Robert J; Kaplan, Frederick S; Wang, Haitao · 2024 · Biomolecules · DOI

Full title: Cell Senescence in Heterotopic Ossification.

Authors: Pignolo, Robert J; Kaplan, Frederick S; Wang, Haitao

Year: 2024

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom14040485

Paper Accumulation of CD28null Senescent T-Cells Is Associated with Poorer Outcomes in COVID19 Patients

Coleman, Mia J.; Zimmerly, Kourtney M.; Yang, Xuexian O. · 2021 · Biomolecules · DOI

Full title: Accumulation of CD28null Senescent T-Cells Is Associated with Poorer Outcomes in COVID19 Patients

Authors: Coleman, Mia J.; Zimmerly, Kourtney M.; Yang, Xuexian O.

Year: 2021

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom11101425

Paper Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging Interventions.

Saliev, Timur; Singh, Prim B · 2025 · Biomolecules · DOI

Full title: Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging Interventions.

Authors: Saliev, Timur; Singh, Prim B

Year: 2025

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom15060860

Paper Inflammaging and Senescence-Driven Extracellular Matrix Remodeling in Age-Associated Cardiovascular Disease.

Młynarska, Ewelina; Kowalik, Adrianna; Krajewska, Agnieszka et al. · 2025 · Biomolecules · DOI

Full title: Inflammaging and Senescence-Driven Extracellular Matrix Remodeling in Age-Associated Cardiovascular Disease.

Authors: Młynarska, Ewelina; Kowalik, Adrianna; Krajewska, Agnieszka; Krupińska, Natalia; Marcinkowska, Weronika; Motor, Jakub; Przybylak, Aleksandra; Tłustochowicz, Katarzyna; Rysz, Jacek; Franczyk, Beata

Year: 2025

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom15101452

Paper The Role of Senolytics in Osteoporosis

Erman Chen; Jingjing Zhang; Han Chen et al. · 2025 · Biomolecules · DOI

Full title: The Role of Senolytics in Osteoporosis

Authors: Erman Chen; Jingjing Zhang; Han Chen; Weixu Li

Year: 2025

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom15081176

Paper The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches.

Burdusel, Daiana; Doeppner, Thorsten R; Surugiu, Roxana et al. · 2024 · Biomolecules · DOI

Full title: The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches.

Authors: Burdusel, Daiana; Doeppner, Thorsten R; Surugiu, Roxana; Hermann, Dirk M; Olaru, Denissa Greta; Popa-Wagner, Aurel

Year: 2024

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom15010018

Paper Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration

Julia Delenko; Nathaniel Hyman; Prodyot K. Chatterjee et al. · 2025 · Biomolecules · DOI

Full title: Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration

Authors: Julia Delenko; Nathaniel Hyman; Prodyot K. Chatterjee; Polona Safaric Tepes; Andrew J Shih; Xiangying Xue; Jane Gurney; Andrew G. Baker; Cheng Wei; Daniel Munoz Espin; L. Fruk; Peter K. Gregersen; Christine N. Metz

Year: 2025

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom15060873

Paper Cellular Senescence in Liver Cancer: How Dying Cells Become “Zombie” Enemies

Gazzillo, Aurora; Volponi, Camilla; Soldani, Cristiana et al. · 2023 · Biomedicines · DOI

Full title: Cellular Senescence in Liver Cancer: How Dying Cells Become “Zombie” Enemies

Authors: Gazzillo, Aurora; Volponi, Camilla; Soldani, Cristiana; Polidoro, Michela Anna; Franceschini, Barbara; Lleò, Ana; Bonavita, Eduardo; Donadon, Matteo

Year: 2023

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines12010026

Paper Therapeutic Antiaging Strategies

Mishra, Shailendra Kumar; Balendra, Vyshnavy; Esposto, Josephine et al. · 2022 · Biomedicines · DOI

Full title: Therapeutic Antiaging Strategies

Authors: Mishra, Shailendra Kumar; Balendra, Vyshnavy; Esposto, Josephine; Obaid, Ahmad A.; Maccioni, Ricardo B.; Jha, Niraj Kumar; Perry, George; Moustafa, Mahmoud; Al-Shehri, Mohammed; Singh, Mahendra Pratap; Khan, Anmar A.; Vamanu, Emanuel; Singh, Sandeep Kumar

Year: 2022

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines10102515

Paper The Combination of Radiation with PARP Inhibition Enhances Senescence and Sensitivity to the Senolytic, Navitoclax, in Triple Negative Breast Tumor Cells

Abrar Softah; M. Alotaibi; Ali R. Alhoshani et al. · 2023 · Biomedicines · DOI

Full title: The Combination of Radiation with PARP Inhibition Enhances Senescence and Sensitivity to the Senolytic, Navitoclax, in Triple Negative Breast Tumor Cells

Authors: Abrar Softah; M. Alotaibi; Ali R. Alhoshani; T. Saleh; Khalid Alhazzani; M. Almutairi; Raed Alrowis; Samiyah Alshehri; Norah A. Albekairy; Hisashi Harada; Rowan Boyd; Eesha Chakraborty; David A. Gewirtz; Homood M As Sobeai

Year: 2023

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines11113066

Paper Non-Healing Perianal Fistulas: A Clinical Model of Tissue Senescence Impairing Both Tissue Fibrosis and Regenerative Potential

Llaneras, Jason; Belza, Caitlyn C.; Eisenstein, Samuel et al. · 2023 · Biomedicines · DOI

Full title: Non-Healing Perianal Fistulas: A Clinical Model of Tissue Senescence Impairing Both Tissue Fibrosis and Regenerative Potential

Authors: Llaneras, Jason; Belza, Caitlyn C.; Eisenstein, Samuel; Dobke, Marek

Year: 2023

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines11020537

Paper Anti-Tumorigenic Effect of a Novel Derivative of 2-Hydroxyoleic Acid and the Endocannabinoid Anandamide on Neuroblastoma Cells

Golan, Hana; Mechoulam, Raphael; Smoum, Reem et al. · 2022 · Biomedicines · DOI

Full title: Anti-Tumorigenic Effect of a Novel Derivative of 2-Hydroxyoleic Acid and the Endocannabinoid Anandamide on Neuroblastoma Cells

Authors: Golan, Hana; Mechoulam, Raphael; Smoum, Reem; Cohen-Zada, Efrat; Pri‐Chen, Sara; Wiener, Sapir; Grinberg, Igor; Bar‐Lev, Dekel D.; Haj, Christeeneh G.; Fisher, Tamar; Toren, Amos

Year: 2022

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines10071552

Paper Rosmarinic Acid Reduces Microglia Senescence: A Novel Therapeutic Approach for the Management of Neuropathic Pain Symptoms

V. Borgonetti; N. Galeotti · 2022 · Biomedicines · DOI

Full title: Rosmarinic Acid Reduces Microglia Senescence: A Novel Therapeutic Approach for the Management of Neuropathic Pain Symptoms

Authors: V. Borgonetti; N. Galeotti

Year: 2022

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines10071468

Paper Could Hyaluronic Acid Be Considered as a Senomorphic Agent in Knee Osteoarthritis? A Systematic Review

Bernetti, Andrea; Agostini, Francesco; Paoloni, Marco et al. · 2023 · Biomedicines · DOI

Full title: Could Hyaluronic Acid Be Considered as a Senomorphic Agent in Knee Osteoarthritis? A Systematic Review

Authors: Bernetti, Andrea; Agostini, Francesco; Paoloni, Marco; Raele, Maria Vittoria; Farì, Giacomo; Megna, Marisa; Mangone, Massimiliano

Year: 2023

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines11102858

Paper Suppressing the Aging Phenotype of Mesenchymal Stromal Cells: Are We Ready for Clinical Translation?

Roato, Ilaria; Visca, Matteo; Mussano, Federico · 2024 · Biomedicines · DOI

Full title: Suppressing the Aging Phenotype of Mesenchymal Stromal Cells: Are We Ready for Clinical Translation?

Authors: Roato, Ilaria; Visca, Matteo; Mussano, Federico

Year: 2024

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines12122811

Paper Senescent Macrophages Release Inflammatory Cytokines and RNA-Loaded Extracellular Vesicles to Circumvent Fibroblast Senescence

Camille Laliberté; Bianca Bossé; V. Bourdeau et al. · 2024 · Biomedicines · DOI

Full title: Senescent Macrophages Release Inflammatory Cytokines and RNA-Loaded Extracellular Vesicles to Circumvent Fibroblast Senescence

Authors: Camille Laliberté; Bianca Bossé; V. Bourdeau; Luis I. Prieto; Genève Perron-Deshaies; Nhung Vuong-Robillard; S. Igelmann; L. Aguilar; Marlene Oeffinger; Darren J. Baker; Luc DesGroseillers; Gerardo Ferbeyre

Year: 2024

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines12051089

Paper Understanding the Complex Dynamics of Immunosenescence in Multiple Sclerosis: From Pathogenesis to Treatment

Neațu, Monica; Hera-Drăguț, Ana; Ioniță, Iulia et al. · 2024 · Biomedicines · DOI

Full title: Understanding the Complex Dynamics of Immunosenescence in Multiple Sclerosis: From Pathogenesis to Treatment

Authors: Neațu, Monica; Hera-Drăguț, Ana; Ioniță, Iulia; Jugurt, Ana; Davidescu, Eugenia Irene; Popescu, Bogdan Ovidiu

Year: 2024

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines12081890

Paper Role of Cellular Senescence in Parkinson’s Disease: Potential for Disease-Modification Through Senotherapy

David J. Rademacher; Jacob E. Exline; Eileen M. Foecking · 2025 · Biomedicines · DOI

Full title: Role of Cellular Senescence in Parkinson’s Disease: Potential for Disease-Modification Through Senotherapy

Authors: David J. Rademacher; Jacob E. Exline; Eileen M. Foecking

Year: 2025

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines13061400

Paper Cellular Senescence: The Driving Force of Musculoskeletal Diseases.

Falvino, Angela; Gasperini, Beatrice; Cariati, Ida et al. · 2024 · Biomedicines · DOI

Full title: Cellular Senescence: The Driving Force of Musculoskeletal Diseases.

Authors: Falvino, Angela; Gasperini, Beatrice; Cariati, Ida; Bonanni, Roberto; Chiavoghilefu, Angela; Gasbarra, Elena; Botta, Annalisa; Tancredi, Virginia; Tarantino, Umberto

Year: 2024

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines12091948

Paper Targeting Cellular Senescence: Pathophysiology in Multisystem Age-Related Diseases.

Liu, Jinxue; Yu, Hongliang; Xu, Yuanyuan · 2025 · Biomedicines · DOI

Full title: Targeting Cellular Senescence: Pathophysiology in Multisystem Age-Related Diseases.

Authors: Liu, Jinxue; Yu, Hongliang; Xu, Yuanyuan

Year: 2025

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines13071727

Paper Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function

Perez-Serna, Atenea A.; Guzman-Llorens, Daniel; Santos, Reinaldo S. Dos et al. · 2025 · Biomedicines · DOI

Full title: Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function

Authors: Perez-Serna, Atenea A.; Guzman-Llorens, Daniel; Santos, Reinaldo S. Dos; Marroquí, Laura

Year: 2025

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines13010223

Paper Cellular Senescence: Mechanisms and Therapeutic Potential

Liao, Zehuan; Yeo, Han Lin; Wong, Siaw Wen et al. · 2021 · Biomedicines · DOI

Full title: Cellular Senescence: Mechanisms and Therapeutic Potential

Authors: Liao, Zehuan; Yeo, Han Lin; Wong, Siaw Wen; Zhao, Yan

Year: 2021

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines9121769

Paper The Premature Senescence in Breast Cancer Treatment Strategy.

Milczarek, Małgorzata · 2020 · Cancers · DOI

Full title: The Premature Senescence in Breast Cancer Treatment Strategy.

Authors: Milczarek, Małgorzata

Year: 2020

Venue: Cancers

DOI: https://doi.org/10.3390/cancers12071815

Paper Targeting Dermal Fibroblast Senescence: From Cellular Plasticity to Anti-Aging Therapies.

Jipu, Raluca; Serban, Ionela Lacramioara; Goriuc, Ancuta et al. · 2025 · Biomedicines · DOI

Full title: Targeting Dermal Fibroblast Senescence: From Cellular Plasticity to Anti-Aging Therapies.

Authors: Jipu, Raluca; Serban, Ionela Lacramioara; Goriuc, Ancuta; Jipu, Alexandru Gabriel; Luchian, Ionut; Amititeloaie, Carmen; Tarniceriu, Claudia Cristina; Hurjui, Ion; Butnaru, Oana Maria; Hurjui, Loredana Liliana

Year: 2025

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines13081927

Paper The Role of Cellular Senescence and SASP in the Pathogenesis of Atherosclerosis and the Therapeutic Potential of Senolytic Strategies in Cardiovascular Diseases

Zuzanna Krupa; Joanna Wrona; Marta Zawadzka et al. · 2026 · Biomedicines · DOI

Full title: The Role of Cellular Senescence and SASP in the Pathogenesis of Atherosclerosis and the Therapeutic Potential of Senolytic Strategies in Cardiovascular Diseases

Authors: Zuzanna Krupa; Joanna Wrona; Marta Zawadzka; Julia Rydzek; Julia Lizon; Paulina Kalemba; Konrad Kochman; Paweł Iwaszkiewicz; R. Iwanowski; Sławomir Woźniak

Year: 2026

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines14020331

Paper Mechanistic Links Between the Gut Microbiome and Longevity Therapeutics

Noelia Garzon-Escamilla; Miriam Medina-Cardena; Preeti Roy et al. · 2026 · Biomedicines · DOI

Full title: Mechanistic Links Between the Gut Microbiome and Longevity Therapeutics

Authors: Noelia Garzon-Escamilla; Miriam Medina-Cardena; Preeti Roy; Jessica Trent; Joud Jamous; Yalini Somesan; Sandy J. Denslow

Year: 2026

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines14020316

Paper Can Blood-Circulating Factors Unveil and Delay Your Biological Aging?

Rybtsova, Natalia; Berezina, Tatiana; Kagansky, Alexander et al. · 2020 · Biomedicines · DOI

Full title: Can Blood-Circulating Factors Unveil and Delay Your Biological Aging?

Authors: Rybtsova, Natalia; Berezina, Tatiana; Kagansky, Alexander; Rybtsov, Stanislav

Year: 2020

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines8120615

Paper Biological Aspects of Inflamm-Aging in Childhood Cancer Survivors

Rossi, Francesca; Paola, Alessandra Di; Pota, Elvira et al. · 2021 · Cancers · DOI

Full title: Biological Aspects of Inflamm-Aging in Childhood Cancer Survivors

Authors: Rossi, Francesca; Paola, Alessandra Di; Pota, Elvira; Argenziano, Maura; Pinto, Daniela; Marrapodi, Maria Maddalena; Leva, Caterina Di; Martino, Martina Di; Tortora, Chiara

Year: 2021

Venue: Cancers

DOI: https://doi.org/10.3390/cancers13194933

Paper Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy

Saleh, Tareq; Bloukh, Sarah; Carpenter, Valerie J. et al. · 2020 · Cancers · DOI

Full title: Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy

Authors: Saleh, Tareq; Bloukh, Sarah; Carpenter, Valerie J.; Alwohoush, Enas; Bakeer, Jomana; Darwish, Sarah; Azab, Belal; Gewirtz, David A.

Year: 2020

Venue: Cancers

DOI: https://doi.org/10.3390/cancers12040822

Paper Senescence and Cancer: Role of Nitric Oxide (NO) in SASP

Mabrouk, Nesrine; Ghione, S; Laurens, Véronique et al. · 2020 · Cancers · DOI

Full title: Senescence and Cancer: Role of Nitric Oxide (NO) in SASP

Authors: Mabrouk, Nesrine; Ghione, S; Laurens, Véronique; Plenchette, Stéphanie; Bettaı̈eb, Ali; Paul, Catherine

Year: 2020

Venue: Cancers

DOI: https://doi.org/10.3390/cancers12051145

Paper Senolytics for Cancer Therapy: Is All that Glitters Really Gold?

Carpenter, Valerie J.; Saleh, Tareq; Gewirtz, David A. · 2021 · Cancers · DOI

Full title: Senolytics for Cancer Therapy: Is All that Glitters Really Gold?

Authors: Carpenter, Valerie J.; Saleh, Tareq; Gewirtz, David A.

Year: 2021

Venue: Cancers

DOI: https://doi.org/10.3390/cancers13040723

Paper Molecular Mechanisms of Senescence and Implications for the Treatment of Myeloid Malignancies.

Ernst, Philipp; Heidel, Florian H · 2021 · Cancers · DOI

Full title: Molecular Mechanisms of Senescence and Implications for the Treatment of Myeloid Malignancies.

Authors: Ernst, Philipp; Heidel, Florian H

Year: 2021

Venue: Cancers

DOI: https://doi.org/10.3390/cancers13040612

Paper Targeting c-IAP1, c-IAP2, and Bcl-2 Eliminates Senescent Glioblastoma Cells Following Temozolomide Treatment

C. Schwarzenbach; Larissa Tatsch; Juliana Brandstetter Vilar et al. · 2021 · Cancers · DOI

Full title: Targeting c-IAP1, c-IAP2, and Bcl-2 Eliminates Senescent Glioblastoma Cells Following Temozolomide Treatment

Authors: C. Schwarzenbach; Larissa Tatsch; Juliana Brandstetter Vilar; Birgit Rasenberger; Lea Beltzig; B. Kaina; M. Tomicic; M. Christmann

Year: 2021

Venue: Cancers

DOI: https://doi.org/10.3390/cancers13143585

Paper Senolysis-Based Elimination of Chemotherapy-Induced Senescent Breast Cancer Cells by Quercetin Derivative with Blocked Hydroxy Groups

A. Lewińska; Paweł Przybylski; J. Adamczyk-Grochala et al. · 2022 · Cancers · DOI

Full title: Senolysis-Based Elimination of Chemotherapy-Induced Senescent Breast Cancer Cells by Quercetin Derivative with Blocked Hydroxy Groups

Authors: A. Lewińska; Paweł Przybylski; J. Adamczyk-Grochala; D. Błoniarz; G. Litwinienko; M. Wnuk

Year: 2022

Venue: Cancers

DOI: https://doi.org/10.3390/cancers14030605

Paper Senescence in HBV-, HCV- and NAFLD- Mediated Hepatocellular Carcinoma and Senotherapeutics: Current Evidence and Future Perspective

Giannakoulis, Vassilis G.; Dubovan, Peter; Papoutsi, Eleni et al. · 2021 · Cancers · DOI

Full title: Senescence in HBV-, HCV- and NAFLD- Mediated Hepatocellular Carcinoma and Senotherapeutics: Current Evidence and Future Perspective

Authors: Giannakoulis, Vassilis G.; Dubovan, Peter; Papoutsi, Eleni; Kataki, Agapi; Koskinas, John

Year: 2021

Venue: Cancers

DOI: https://doi.org/10.3390/cancers13184732

Paper Taking Advantage of the Senescence-Promoting Effect of Olaparib after X-ray and Proton Irradiation Using the Senolytic Drug, ABT-263

Camille Huart; M. Fransolet; C. Demazy et al. · 2022 · Cancers · DOI

Full title: Taking Advantage of the Senescence-Promoting Effect of Olaparib after X-ray and Proton Irradiation Using the Senolytic Drug, ABT-263

Authors: Camille Huart; M. Fransolet; C. Demazy; B. Le Calvé; S. Lucas; C. Michiels; A. Wéra

Year: 2022

Venue: Cancers

DOI: https://doi.org/10.3390/cancers14061460

Paper Implications of Senescent T Cells for Cancer Immunotherapy

Kasamatsu, Tetsuhiro · 2023 · Cancers · DOI

Full title: Implications of Senescent T Cells for Cancer Immunotherapy

Authors: Kasamatsu, Tetsuhiro

Year: 2023

Venue: Cancers

DOI: https://doi.org/10.3390/cancers15245835

Paper The Cross Talk between Cellular Senescence and Melanoma: From Molecular Pathogenesis to Target Therapies

Liu, Jiahua; Zheng, Runzi; Zhang, Yanghuan et al. · 2023 · Cancers · DOI

Full title: The Cross Talk between Cellular Senescence and Melanoma: From Molecular Pathogenesis to Target Therapies

Authors: Liu, Jiahua; Zheng, Runzi; Zhang, Yanghuan; Jia, Shuting; He, Yonghan; Liu, Jing; Liu, Jing; Liu, Jing

Year: 2023

Venue: Cancers

DOI: https://doi.org/10.3390/cancers15092640

Paper Gemcitabine Cooperates with Everolimus to Inhibit the Growth of and Sensitize Malignant Meningioma Cells to Apoptosis Induced by Navitoclax, an Inhibitor of Anti-Apoptotic BCL-2 Family Proteins

Masahiro Yamamoto; Shuhei Suzuki; Keita Togashi et al. · 2022 · Cancers · DOI

Full title: Gemcitabine Cooperates with Everolimus to Inhibit the Growth of and Sensitize Malignant Meningioma Cells to Apoptosis Induced by Navitoclax, an Inhibitor of Anti-Apoptotic BCL-2 Family Proteins

Authors: Masahiro Yamamoto; Shuhei Suzuki; Keita Togashi; Asuka Sugai; M. Okada; C. Kitanaka

Year: 2022

Venue: Cancers

DOI: https://doi.org/10.3390/cancers14071706

Paper Senolytic Flavonoids Enhance Type-I and Type-II Cell Death in Human Radioresistant Colon Cancer Cells through AMPK/MAPK Pathway.

Russo, Maria; Moccia, Stefania; Luongo, Diomira et al. · 2023 · Cancers · DOI

Full title: Senolytic Flavonoids Enhance Type-I and Type-II Cell Death in Human Radioresistant Colon Cancer Cells through AMPK/MAPK Pathway.

Authors: Russo, Maria; Moccia, Stefania; Luongo, Diomira; Russo, Gian Luigi

Year: 2023

Venue: Cancers

DOI: https://doi.org/10.3390/cancers15092660

Paper Mutation Status and Glucose Availability Affect the Response to Mitochondria-Targeted Quercetin Derivative in Breast Cancer Cells

Przybylski, Paweł; Lewińska, Anna; Rzeszutek, Iwona et al. · 2023 · Cancers · DOI

Full title: Mutation Status and Glucose Availability Affect the Response to Mitochondria-Targeted Quercetin Derivative in Breast Cancer Cells

Authors: Przybylski, Paweł; Lewińska, Anna; Rzeszutek, Iwona; Błoniarz, Dominika; Moskal, Aleksandra; Betlej, Gabriela; Deręgowska, Anna; Cybularczyk‐Cecotka, Martyna; Szmatoła, Tomasz; Litwinienko, Grzegorz; Wnuk, Maciej

Year: 2023

Venue: Cancers

DOI: https://doi.org/10.3390/cancers15235614

Paper Senescent Cells in Cancer: Wanted or Unwanted Citizens.

Niklander, Sven E; Lambert, Daniel W; Hunter, Keith D · 2021 · Cells · DOI

Full title: Senescent Cells in Cancer: Wanted or Unwanted Citizens.

Authors: Niklander, Sven E; Lambert, Daniel W; Hunter, Keith D

Year: 2021

Venue: Cells

DOI: https://doi.org/10.3390/cells10123315

Paper The Impact of Senescence-Associated Secretory Phenotype (SASP) on Head and Neck Cancers: From Biology to Therapy.

Alam, Md Tanjim; Mansoor, Mishfak A M; Ashiqueali, Sarah A et al. · 2025 · Cancers · DOI

Full title: The Impact of Senescence-Associated Secretory Phenotype (SASP) on Head and Neck Cancers: From Biology to Therapy.

Authors: Alam, Md Tanjim; Mansoor, Mishfak A M; Ashiqueali, Sarah A; Golusinski, Pawel; Golusinska-Kardach, Ewelina; Strzelczyk, Joanna K; Rubis, Blazej; Golusinski, Wojciech; Masternak, Michal M

Year: 2025

Venue: Cancers

DOI: https://doi.org/10.3390/cancers17244024

Paper The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets

M. Rossi; K. Abdelmohsen · 2021 · Cells · DOI

Full title: The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets

Authors: M. Rossi; K. Abdelmohsen

Year: 2021

Venue: Cells

DOI: https://doi.org/10.3390/cells10071740

Paper Aging of the Immune System: Focus on Natural Killer Cells Phenotype and Functions

Brauning, Ashley; Rae, Michael; Zhu, Gina et al. · 2022 · Cells · DOI

Full title: Aging of the Immune System: Focus on Natural Killer Cells Phenotype and Functions

Authors: Brauning, Ashley; Rae, Michael; Zhu, Gina; Fulton, Elena C.; Admasu, Tesfahun Dessale; Stolzing, Alexandra; Sharma, Amit

Year: 2022

Venue: Cells

DOI: https://doi.org/10.3390/cells11061017

Paper A Review of Telomere Attrition in Cancer and Aging: Current Molecular Insights and Future Therapeutic Approaches

Iskandar, Mina; Barbéro, M.; Jaber, Mohammed Tariq et al. · 2025 · Cancers · DOI

Full title: A Review of Telomere Attrition in Cancer and Aging: Current Molecular Insights and Future Therapeutic Approaches

Authors: Iskandar, Mina; Barbéro, M.; Jaber, Mohammed Tariq; Chen, Roy; Gomez-Guevara, Romulo; Cruz, Edwin; Westerheide, Sandy D.

Year: 2025

Venue: Cancers

DOI: https://doi.org/10.3390/cancers17020257

Paper EA.hy926 Cells and HUVECs Share Similar Senescence Phenotypes but Respond Differently to the Senolytic Drug ABT-263

Ibrahim Y Abdelgawad; Kevin Agostinucci; Somia G. E. Ismail et al. · 2022 · Cells · DOI

Full title: EA.hy926 Cells and HUVECs Share Similar Senescence Phenotypes but Respond Differently to the Senolytic Drug ABT-263

Authors: Ibrahim Y Abdelgawad; Kevin Agostinucci; Somia G. E. Ismail; M. Grant; Beshay N. Zordoky

Year: 2022

Venue: Cells

DOI: https://doi.org/10.3390/cells11131992

Paper The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis.

Wagner, Kay-Dietrich; Wagner, Nicole · 2022 · Cells · DOI

Full title: The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis.

Authors: Wagner, Kay-Dietrich; Wagner, Nicole

Year: 2022

Venue: Cells

DOI: https://doi.org/10.3390/cells11121966

Paper o-Vanillin Modulates Cell Phenotype and Extracellular Vesicles of Human Mesenchymal Stem Cells and Intervertebral Disc Cells

Li Li; K. Sheng; M. Mannarino et al. · 2022 · Cells · DOI

Full title: o-Vanillin Modulates Cell Phenotype and Extracellular Vesicles of Human Mesenchymal Stem Cells and Intervertebral Disc Cells

Authors: Li Li; K. Sheng; M. Mannarino; P. Jarzem; Hosni Cherif; L. Haglund

Year: 2022

Venue: Cells

DOI: https://doi.org/10.3390/cells11223589

Paper Abrogation of Cellular Senescence Induced by Temozolomide in Glioblastoma Cells: Search for Senolytics

Beltzig, Lea; Christmann, Markus; Kaina, Bernd · 2022 · Cells · DOI

Full title: Abrogation of Cellular Senescence Induced by Temozolomide in Glioblastoma Cells: Search for Senolytics

Authors: Beltzig, Lea; Christmann, Markus; Kaina, Bernd

Year: 2022

Venue: Cells

DOI: https://doi.org/10.3390/cells11162588

Paper Senotherapeutics in Cancer and HIV.

Sánchez-Díaz, Laura; Espinosa-Sánchez, Asunción; Blanco, José-Ramón et al. · 2022 · Cells · DOI

Full title: Senotherapeutics in Cancer and HIV.

Authors: Sánchez-Díaz, Laura; Espinosa-Sánchez, Asunción; Blanco, José-Ramón; Carnero, Amancio

Year: 2022

Venue: Cells

DOI: https://doi.org/10.3390/cells11071222

Paper Role of Senescence and Aging in SARS-CoV-2 Infection and COVID-19 Disease

Lynch, Seodhna M.; Guo, Guangran; Gibson, David S. et al. · 2021 · Cells · DOI

Full title: Role of Senescence and Aging in SARS-CoV-2 Infection and COVID-19 Disease

Authors: Lynch, Seodhna M.; Guo, Guangran; Gibson, David S.; Bjourson, Anthony J.; Singh, Taranjit

Year: 2021

Venue: Cells

DOI: https://doi.org/10.3390/cells10123367

Paper Therapeutic Perspectives for Inflammation and Senescence in Osteoarthritis Using Mesenchymal Stem Cells, Mesenchymal Stem Cell-Derived Extracellular Vesicles and Senolytic Agents

Michael G. Rizzo; T. Best; J. Huard et al. · 2023 · Cells · DOI

Full title: Therapeutic Perspectives for Inflammation and Senescence in Osteoarthritis Using Mesenchymal Stem Cells, Mesenchymal Stem Cell-Derived Extracellular Vesicles and Senolytic Agents

Authors: Michael G. Rizzo; T. Best; J. Huard; M. Philippon; F. Hornicek; Z. Duan; Anthony J. Griswold; L. Kaplan; J. Hare; Dimitrios Kouroupis

Year: 2023

Venue: Cells

DOI: https://doi.org/10.3390/cells12101421

Paper Senescent Cells: A Therapeutic Target in Cardiovascular Diseases

M. Suda; Karl H Paul; T. Minamino et al. · 2023 · Cells · DOI

Full title: Senescent Cells: A Therapeutic Target in Cardiovascular Diseases

Authors: M. Suda; Karl H Paul; T. Minamino; Jordan D. Miller; A. Lerman; G. Ellison‐Hughes; T. Tchkonia; J. Kirkland

Year: 2023

Venue: Cells

DOI: https://doi.org/10.3390/cells12091296

Paper Merkel Cell Polyomavirus Large T Antigen Induces Cellular Senescence for Host Growth Arrest and Viral Genome Persistence through Its Unique Domain

A. M. Pham; Luz E. Ortiz; A. Lukacher et al. · 2023 · Cells · DOI

Full title: Merkel Cell Polyomavirus Large T Antigen Induces Cellular Senescence for Host Growth Arrest and Viral Genome Persistence through Its Unique Domain

Authors: A. M. Pham; Luz E. Ortiz; A. Lukacher; H. Kwun

Year: 2023

Venue: Cells

DOI: https://doi.org/10.3390/cells12030380

Paper Emerging Therapeutic Approaches to Target the Dark Side of Senescent Cells: New Hopes to Treat Aging as a Disease and to Delay Age-Related Pathologies.

Khalil, Roula; Diab-Assaf, Mona; Lemaitre, Jean-Marc · 2023 · Cells · DOI

Full title: Emerging Therapeutic Approaches to Target the Dark Side of Senescent Cells: New Hopes to Treat Aging as a Disease and to Delay Age-Related Pathologies.

Authors: Khalil, Roula; Diab-Assaf, Mona; Lemaitre, Jean-Marc

Year: 2023

Venue: Cells

DOI: https://doi.org/10.3390/cells12060915

Paper Age Is Just a Number: Progress and Obstacles in the Discovery of New Candidate Drugs for Sarcopenia

Kim, Hyun-Jun; Jung, Da‐Woon; Williams, Darren R. · 2023 · Cells · DOI

Full title: Age Is Just a Number: Progress and Obstacles in the Discovery of New Candidate Drugs for Sarcopenia

Authors: Kim, Hyun-Jun; Jung, Da‐Woon; Williams, Darren R.

Year: 2023

Venue: Cells

DOI: https://doi.org/10.3390/cells12222608

Paper The Hippo Signaling Pathway Manipulates Cellular Senescence

Miyajima, Chiharu; Nagasaka, Mai; Aoki, Hiromasa et al. · 2024 · Cells · DOI

Full title: The Hippo Signaling Pathway Manipulates Cellular Senescence

Authors: Miyajima, Chiharu; Nagasaka, Mai; Aoki, Hiromasa; Toriuchi, Kohki; Yamanaka, Sumitaka; Hashiguchi, S.; Morishita, Daisuke; Aoyama, Mineyoshi; Hayashi, Hidetoshi; Inoue, Yasumichi

Year: 2024

Venue: Cells

DOI: https://doi.org/10.3390/cells14010013

Paper Senescence and Aging: Does It Impact Cancer Immunotherapies?

Maggiorani, Damien; Beauséjour, Christian · 2021 · Cells · DOI

Full title: Senescence and Aging: Does It Impact Cancer Immunotherapies?

Authors: Maggiorani, Damien; Beauséjour, Christian

Year: 2021

Venue: Cells

DOI: https://doi.org/10.3390/cells10071568

Paper Lipophilic Statins Eliminate Senescent Endothelial Cells by inducing Anoikis-Related Cell Death

Beláková, Barbora; Wedige, Nicholas K.; Awad, Ezzat M. et al. · 2023 · Cells · DOI

Full title: Lipophilic Statins Eliminate Senescent Endothelial Cells by inducing Anoikis-Related Cell Death

Authors: Beláková, Barbora; Wedige, Nicholas K.; Awad, Ezzat M.; Heß, Simon; Oszwald, André; Fellner, Marlene; Khan, Shafaat Yar; Resch, Ulrike; Lipovac, Markus; Šmejkal, Karel; Uhrín, Pavel; Breuss, Johannes M.

Year: 2023

Venue: Cells

DOI: https://doi.org/10.3390/cells12242836

Paper Statins in Chronic Kidney Disease—Effects on Atherosclerosis and Cellular Senescence

Fularski, Piotr; Krzemińska, Julia; Lewandowska, Natalia et al. · 2023 · Cells · DOI

Full title: Statins in Chronic Kidney Disease—Effects on Atherosclerosis and Cellular Senescence

Authors: Fularski, Piotr; Krzemińska, Julia; Lewandowska, Natalia; Młynarska, Ewelina; Saar, Maciej; Wronka, Magdalena; Rysz, Jacek; Franczyk, Beata

Year: 2023

Venue: Cells

DOI: https://doi.org/10.3390/cells12131679

Paper In vitro senescence and senolytic functional assays.

Patrick Ryan; Jungwoo Lee · 2025 · Biomaterials Science · DOI

Full title: In vitro senescence and senolytic functional assays.

Authors: Patrick Ryan; Jungwoo Lee

Year: 2025

Venue: Biomaterials Science

DOI: https://doi.org/10.1039/d4bm01684j

Paper JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Xu, Ming; Tchkonia, Tamar; Ding, Husheng et al. · 2015 · Proceedings of the National Academy of Sciences · DOI

Full title: JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Authors: Xu, Ming; Tchkonia, Tamar; Ding, Husheng; Ogrodnik, Mikołaj; Lubbers, Ellen R.; Pirtskhalava, Tamar; White, Thomas A.; Johnson, Kurt O.; Stout, Michael B.; Mezera, Vojtěch; Giorgadze, Nino; Jensen, Michael D.; LeBrasseur, Nathan K.; Kirkland, James L.

Year: 2015

Venue: Proceedings of the National Academy of Sciences

DOI: https://doi.org/10.1073/pnas.1515386112

Paper Senolytic and senomorphic agent procyanidin C1 alleviates structural and functional decline in the aged retina

Yidan Liu; Xiuxing Liu; Xuhao Chen et al. · 2024 · Proceedings of the National Academy of Sciences of the United States of America · DOI

Full title: Senolytic and senomorphic agent procyanidin C1 alleviates structural and functional decline in the aged retina

Authors: Yidan Liu; Xiuxing Liu; Xuhao Chen; Zhenlan Yang; Jianqi Chen; Weining Zhu; Yangyang Li; Yuwen Wen; C. Deng; Chenyang Gu; Jianjie Lv; Rong Ju; Yehong Zhuo; Wenru Su

Year: 2024

Venue: Proceedings of the National Academy of Sciences of the United States of America

DOI: https://doi.org/10.1073/pnas.2311028121

Paper Targeting BCL-xL improves the efficacy of bromodomain and extra-terminal protein inhibitors in triple-negative breast cancer by eliciting the death of senescent cells.

Gayle, Sylvia S; Sahni, Jennifer M; Webb, Bryan M et al. · 2019 · The Journal of biological chemistry · DOI

Full title: Targeting BCL-xL improves the efficacy of bromodomain and extra-terminal protein inhibitors in triple-negative breast cancer by eliciting the death of senescent cells.

Authors: Gayle, Sylvia S; Sahni, Jennifer M; Webb, Bryan M; Weber-Bonk, Kristen L; Shively, Melyssa S; Spina, Raffaella; Bar, Eli E; Summers, Mathew K; Keri, Ruth A

Year: 2019

Venue: The Journal of biological chemistry

DOI: https://doi.org/10.1074/jbc.RA118.004712

Paper Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis.

Fournier, Frédérik; Diaz-Marin, Roberto; Pilon, Frédérique et al. · 2023 · Proceedings of the National Academy of Sciences of the United States of America · DOI

Full title: Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis.

Authors: Fournier, Frédérik; Diaz-Marin, Roberto; Pilon, Frédérique; Neault, Mathieu; Juneau, Rachel; Girouard, Gabrielle; Wilson, Ariel M; Larrivée, Bruno; Mallette, Frédérick A; Crespo-Garcia, Sergio; Sapieha, Przemyslaw

Year: 2023

Venue: Proceedings of the National Academy of Sciences of the United States of America

DOI: https://doi.org/10.1073/pnas.2209973120

Paper A second generation of senotherapies: the development of targeted senolytics, senoblockers and senoreversers for healthy ageing.

Dhokia, Vinesh; Albati, Amal; Smith, Hannah et al. · 2024 · Biochemical Society transactions · DOI

Full title: A second generation of senotherapies: the development of targeted senolytics, senoblockers and senoreversers for healthy ageing.

Authors: Dhokia, Vinesh; Albati, Amal; Smith, Hannah; Thomas, Gethin; Macip, Salvador

Year: 2024

Venue: Biochemical Society transactions

DOI: https://doi.org/10.1042/BST20231066

Paper Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies.

Liu, Danlin; Richardson, Gavin; Benli, Fehmi M et al. · 2020 · Clinical science (London, England : 1979) · DOI

Full title: Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies.

Authors: Liu, Danlin; Richardson, Gavin; Benli, Fehmi M; Park, Catherine; de Souza, João V; Bronowska, Agnieszka K; Spyridopoulos, Ioakim

Year: 2020

Venue: Clinical science (London, England : 1979)

DOI: https://doi.org/10.1042/CS20191213

Paper Oligodendrocytes in the aging brain

Sams, Eleanor Catherine · 2021 · Neuronal Signaling · DOI

Full title: Oligodendrocytes in the aging brain

Authors: Sams, Eleanor Catherine

Year: 2021

Venue: Neuronal Signaling

DOI: https://doi.org/10.1042/ns20210008

Paper Hsp90 inhibitors as senolytic drugs to extend healthy aging

Heike Fuhrmann-Stroissnigg; L. Niedernhofer; P. Robbins · 2018 · Cell Cycle · DOI

Full title: Hsp90 inhibitors as senolytic drugs to extend healthy aging

Authors: Heike Fuhrmann-Stroissnigg; L. Niedernhofer; P. Robbins

Year: 2018

Venue: Cell Cycle

DOI: https://doi.org/10.1080/15384101.2018.1475828

Paper The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications

Nathan Basisty; Abhijit Kale; Sandip K. Patel et al. · 2020 · Espert Review of Proteomics · DOI

Full title: The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications

Authors: Nathan Basisty; Abhijit Kale; Sandip K. Patel; J. Campisi; B. Schilling

Year: 2020

Venue: Espert Review of Proteomics

DOI: https://doi.org/10.1080/14789450.2020.1766976

Paper Senescent cells: targeting and therapeutic potential of senolytics in age-related diseases with a particular focus on the heart.

Ellison-Hughes, Georgina M · 2020 · Expert opinion on therapeutic targets · DOI

Full title: Senescent cells: targeting and therapeutic potential of senolytics in age-related diseases with a particular focus on the heart.

Authors: Ellison-Hughes, Georgina M

Year: 2020

Venue: Expert opinion on therapeutic targets

DOI: https://doi.org/10.1080/14728222.2020.1798403

Paper From Development to Aging: The Path to Cellular Senescence

A. Sacco; L. Belloni; L. Latella · 2020 · Antioxidants and Redox Signaling · DOI

Full title: From Development to Aging: The Path to Cellular Senescence

Authors: A. Sacco; L. Belloni; L. Latella

Year: 2020

Venue: Antioxidants and Redox Signaling

DOI: https://doi.org/10.1089/ars.2020.8071

Paper Cellular senescence and polycystic ovary syndrome: mechanisms and therapeutic strategies from a new perspective.

Xin, Xin; Dong, Li; Li, Jiaxi et al. · 2025 · Annals of medicine · DOI

Full title: Cellular senescence and polycystic ovary syndrome: mechanisms and therapeutic strategies from a new perspective.

Authors: Xin, Xin; Dong, Li; Li, Jiaxi; Zhang, Jinfu; Wu, Haicui

Year: 2025

Venue: Annals of medicine

DOI: https://doi.org/10.1080/07853890.2025.2565437

Paper Cellular senescence is a promising target for chronic wounds: a comprehensive review

Wang, Ziwen; Shi, Chunmeng · 2020 · Burns & Trauma · DOI

Full title: Cellular senescence is a promising target for chronic wounds: a comprehensive review

Authors: Wang, Ziwen; Shi, Chunmeng

Year: 2020

Venue: Burns & Trauma

DOI: https://doi.org/10.1093/burnst/tkaa021

Paper Ligand-specific regulation of a binary enhancer code dictating cellular senescence

Suter, Thomas; Friedman, Meyer J.; Tazearslan, Cagdas et al. · 2025 · Proceedings of the National Academy of Sciences · DOI

Full title: Ligand-specific regulation of a binary enhancer code dictating cellular senescence

Authors: Suter, Thomas; Friedman, Meyer J.; Tazearslan, Cagdas; Merkurjev, Daria; Ohgi, Kenny; Meluzzi, Dario; Rosenfeld, Michael G.; Suh, Yousin

Year: 2025

Venue: Proceedings of the National Academy of Sciences

DOI: https://doi.org/10.1073/pnas.2506321122

Paper Interacting NAD+ and Cell Senescence Pathways Complicate Antiaging Therapies

A. Mendelsohn; J. Larrick · 2019 · Rejuvenation Research · DOI

Full title: Interacting NAD+ and Cell Senescence Pathways Complicate Antiaging Therapies

Authors: A. Mendelsohn; J. Larrick

Year: 2019

Venue: Rejuvenation Research

DOI: https://doi.org/10.1089/rej.2019.2218

Paper A focused natural compound screen reveals senolytic and senostatic effects of Isatis tinctoria

Eun-Jung Kim; J. Woo; Seoungwoo Shin et al. · 2022 · Animal Cells and Systems · DOI

Full title: A focused natural compound screen reveals senolytic and senostatic effects of Isatis tinctoria

Authors: Eun-Jung Kim; J. Woo; Seoungwoo Shin; H. Choi; Young-Sung Kim; Junoh Kim; Chanhee Kang

Year: 2022

Venue: Animal Cells and Systems

DOI: https://doi.org/10.1080/19768354.2022.2143895

Paper New Horizons in cellular senescence for clinicians.

Witham, Miles D; Granic, Antoneta; Miwa, Satomi et al. · 2023 · Age and ageing · DOI

Full title: New Horizons in cellular senescence for clinicians.

Authors: Witham, Miles D; Granic, Antoneta; Miwa, Satomi; Passos, Joao F; Richardson, Gavin D; Sayer, Avan A

Year: 2023

Venue: Age and ageing

DOI: https://doi.org/10.1093/ageing/afad127

Paper Murine transfer of a human gene variant associated with exceptional longevity displays senolytic effects both in immune compartment and endothelium of aged mice

E. Ciaglia; F. Montella; M. Malavolta et al. · 2020 · DOI

Full title: Murine transfer of a human gene variant associated with exceptional longevity displays senolytic effects both in immune compartment and endothelium of aged mice

Authors: E. Ciaglia; F. Montella; M. Malavolta; Albino Carrizzo; V. Lopardo; C. Vecchione; A. Puca

Year: 2020

DOI: https://doi.org/10.1093/ehjci/ehaa946.3830

Paper Pharmacological Targeting of Senescence with ABT-263 in Experimental Heart Failure with Preserved Ejection Fraction

E. Silva; I. Tomé; F. Vasques-Nóvoa et al. · 2022 · Cardiovascular Research · DOI

Full title: Pharmacological Targeting of Senescence with ABT-263 in Experimental Heart Failure with Preserved Ejection Fraction

Authors: E. Silva; I. Tomé; F. Vasques-Nóvoa; A. Silva; G. Conceição; D. Miranda-Silva; P. Pitrez; António S. Barros; A. Leite-Moreira; P. Pinto-do-Ó; S. Santos; IF Pires; L. Ferreira; D. Nascimento

Year: 2022

Venue: Cardiovascular Research

DOI: https://doi.org/10.1093/cvr/cvac066.107

Paper P08 Exploring the role of cellular senescence in cutaneous repair

Alexander Johns; Holly Wilkinson · 2024 · British Journal of Dermatology · DOI

Full title: P08 Exploring the role of cellular senescence in cutaneous repair

Authors: Alexander Johns; Holly Wilkinson

Year: 2024

Venue: British Journal of Dermatology

DOI: https://doi.org/10.1093/bjd/ljae105.030

Paper Mitochondrial-Derived Peptides Exacerbate Senescence

A. Mendelsohn; J. Larrick · 2018 · Rejuvenation Research · DOI

Full title: Mitochondrial-Derived Peptides Exacerbate Senescence

Authors: A. Mendelsohn; J. Larrick

Year: 2018

Venue: Rejuvenation Research

DOI: https://doi.org/10.1089/rej.2018.2114

Paper Elimination of senescent cells targeting Senescence associated glycoprotein (SAGP) improved the ageing-associated diseases and extended the lifespan

M. Suda; I. Shimizu; G. Katsuumi et al. · 2020 · DOI

Full title: Elimination of senescent cells targeting Senescence associated glycoprotein (SAGP) improved the ageing-associated diseases and extended the lifespan

Authors: M. Suda; I. Shimizu; G. Katsuumi; Y. Yoshida; Y. Hayashi; Masaaki Nakao; Ryutaro Ikegami; R. Furuuchi; T. Ozawa; K. Ozaki; T. Minamino

Year: 2020

DOI: https://doi.org/10.1093/ehjci/ehaa946.3573

Paper Senolytics and cell senescence: historical and evolutionary perspectives.

C. Finch · 2024 · Evolution, Medicine and Public Health · DOI

Full title: Senolytics and cell senescence: historical and evolutionary perspectives.

Authors: C. Finch

Year: 2024

Venue: Evolution, Medicine and Public Health

DOI: https://doi.org/10.1093/emph/eoae007

Paper Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis

Stojanović, Stevan D.; Fiedler, Jan; Bauersachs, Johann et al. · 2019 · European Heart Journal · DOI

Full title: Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis

Authors: Stojanović, Stevan D.; Fiedler, Jan; Bauersachs, Johann; Thum, Thomas; Sedding, Daniel

Year: 2019

Venue: European Heart Journal

DOI: https://doi.org/10.1093/eurheartj/ehz919

Paper Does Donor Age Have Effects on Senescence Biomarkers in Kidney-Transplanted Patients?

Juan López-Pérez; Juan Miguel Suarez-Rivero; Inés Muela-Zarzuela et al. · 2024 · Antioxidants and Redox Signaling · DOI

Full title: Does Donor Age Have Effects on Senescence Biomarkers in Kidney-Transplanted Patients?

Authors: Juan López-Pérez; Juan Miguel Suarez-Rivero; Inés Muela-Zarzuela; Raquel de la Varga-Martínez; Aurora Aguilera; Teresa Garcia; Antonio Nieto-Díaz; A. Mazuecos; Mario D. Cordero

Year: 2024

Venue: Antioxidants and Redox Signaling

DOI: https://doi.org/10.1089/ars.2023.0470

Paper Digoxin reduces senescence and restores dysfunctional endothelial-subcutaneous adipocyte cross-talk and dysregulated glucose homeostasis in patients with type 2 diabetes mellitus

O. Brown; K. Bridge; S. Straw et al. · 2024 · European Heart Journal · DOI

Full title: Digoxin reduces senescence and restores dysfunctional endothelial-subcutaneous adipocyte cross-talk and dysregulated glucose homeostasis in patients with type 2 diabetes mellitus

Authors: O. Brown; K. Bridge; S. Straw; C. Luk; N. Makava; M. Tayebjee; C. Saunderson; A. Bruns; M. Drozd; J. Gierula; S. Wheatcroft; K. Witte; R. Cubbon; M. Kearney

Year: 2024

Venue: European Heart Journal

DOI: https://doi.org/10.1093/eurheartj/ehae666.3882

Paper Anti-senescence therapies: a new concept to address cardiovascular disease.

Stojanović, Stevan D; Thum, Thomas; Bauersachs, Johann · 2025 · Cardiovascular research · DOI

Full title: Anti-senescence therapies: a new concept to address cardiovascular disease.

Authors: Stojanović, Stevan D; Thum, Thomas; Bauersachs, Johann

Year: 2025

Venue: Cardiovascular research

DOI: https://doi.org/10.1093/cvr/cvaf030

Paper National Institute on Aging Workshop: Repurposing Drugs or Dietary Supplements for Their Senolytic or Senomorphic Effects: Considerations for Clinical Trials.

Romashkan, Sergei; Chang, Henry; Hadley, Evan C · 2021 · The journals of gerontology. Series A, Biological sciences and medical sciences · DOI

Full title: National Institute on Aging Workshop: Repurposing Drugs or Dietary Supplements for Their Senolytic or Senomorphic Effects: Considerations for Clinical Trials.

Authors: Romashkan, Sergei; Chang, Henry; Hadley, Evan C

Year: 2021

Venue: The journals of gerontology. Series A, Biological sciences and medical sciences

DOI: https://doi.org/10.1093/gerona/glab028

Paper Can removal of zombie cells revitalize the aging cardiovascular system?

Saravi, Seyed Soheil Saeedi; Feinberg, Mark W. · 2024 · European Heart Journal · DOI

Full title: Can removal of zombie cells revitalize the aging cardiovascular system?

Authors: Saravi, Seyed Soheil Saeedi; Feinberg, Mark W.

Year: 2024

Venue: European Heart Journal

DOI: https://doi.org/10.1093/eurheartj/ehad849

Paper The potential role and therapeutic relevance of cellular senescence in skeletal pathophysiology.

Bo Li; Ping Lyu; Jinru Tang et al. · 2024 · The journals of gerontology. Series A, Biological sciences and medical sciences · DOI

Full title: The potential role and therapeutic relevance of cellular senescence in skeletal pathophysiology.

Authors: Bo Li; Ping Lyu; Jinru Tang; Jingya Li; T. Ouchi; Yi Fan; Zhihe Zhao; Longjiang Li

Year: 2024

Venue: The journals of gerontology. Series A, Biological sciences and medical sciences

DOI: https://doi.org/10.1093/gerona/glae037

Paper Allicin Reversed the Process of Frailty in Aging Male Fischer 344 Rats With Osteoporosis

Liu, Yang; You, Meigui; Shen, Jianwei et al. · 2019 · The Journals of Gerontology Series A · DOI

Full title: Allicin Reversed the Process of Frailty in Aging Male Fischer 344 Rats With Osteoporosis

Authors: Liu, Yang; You, Meigui; Shen, Jianwei; Xu, Yaping; Li, Lin; Wang, Dongtao; Yang, Yajun

Year: 2019

Venue: The Journals of Gerontology Series A

DOI: https://doi.org/10.1093/gerona/glz205

Paper Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway–UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies

Wang, Heling; Siow, Richard; Schmauck‐Medina, Tomas et al. · 2024 · The Journals of Gerontology Series A · DOI

Full title: Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway–UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies

Authors: Wang, Heling; Siow, Richard; Schmauck‐Medina, Tomas; Zhang, Jianying; Sandset, Per Morten; Filshie, Clare; Lund, Øystein; Partridge, Linda; Bergersen, Linda H.; Rasmussen, Lene Juel; Palikaras, Konstantinos; Sotiropoulos, Ioannis; Storm‐Mathisen, Jon; Rubinsztein, David C.; Spillantini, Maria Grazia; Zeeuw, Chris I. De; Watne, Leiv Otto; Vyhnálek, Martin; Veverová, Kateřina; Liang, Kristina Xiao; Tavernarakis, Nektarios; Bohr, Vilhelm A.; Yokote, Koutaro; Saarela, Janna; Nilsen, Hilde; Gonos, Efstathios S.; Scheibye‐Knudsen, Morten; Chen, Guobing; Kato, Hisaya; Selbæk, Geir; Fladby, Tormod; Nilsson, Per; Simonsen, Anne; Aarsland, Dag; Lautrup, Sofie; Ottersen, Ole Petter; Cox, Lynne S.; Fang, Evandro Fei

Year: 2024

Venue: The Journals of Gerontology Series A

DOI: https://doi.org/10.1093/gerona/glae029

Paper Vaccination targeting senescence-associated transmembrane protein alleviated cardiovascular pathology in the mice

C. L. Hsiao; G. Katsuumi; Y. Yoshida et al. · 2024 · European Heart Journal · DOI

Full title: Vaccination targeting senescence-associated transmembrane protein alleviated cardiovascular pathology in the mice

Authors: C. L. Hsiao; G. Katsuumi; Y. Yoshida; T. Furihata; Y. Joki; R. Furuuchi; J. Q. Liang; H. Nakagami; T. Minamino

Year: 2024

Venue: European Heart Journal

DOI: https://doi.org/10.1093/eurheartj/ehae666.3654

Paper SAAM-1 senolytic vaccination alleviates atherosclerosis and cardiac dysfunction in mouse models

C. L. Hsiao; G. Katuumi; Y. Yoshida et al. · 2025 · European Heart Journal · DOI

Full title: SAAM-1 senolytic vaccination alleviates atherosclerosis and cardiac dysfunction in mouse models

Authors: C. L. Hsiao; G. Katuumi; Y. Yoshida; T. Furihata; J. Yusuke; R. Furuuchi; H. Nakagami; T. Minamino

Year: 2025

Venue: European Heart Journal

DOI: https://doi.org/10.1093/eurheartj/ehaf784.4627

Paper Epigenetics and Aging in Killifish

A. Brunet · 2020 · Innovation in aging · DOI

Full title: Epigenetics and Aging in Killifish

Authors: A. Brunet

Year: 2020

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igaa057.2661

Paper Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes

Justice, Jamie N.; Miller, Jordan D.; Newman, John C. et al. · 2016 · The Journals of Gerontology Series A · DOI

Full title: Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes

Authors: Justice, Jamie N.; Miller, Jordan D.; Newman, John C.; Hashmi, Shahrukh K.; Halter, Jeffrey B.; Austad, Steve; Barzilai, Nir; Kirkland, James L.

Year: 2016

Venue: The Journals of Gerontology Series A

DOI: https://doi.org/10.1093/gerona/glw126

Paper DNA Damage, Cellular Senescence in Health and Disease

Laura Neidernhofer · 2020 · Innovation in aging · DOI

Full title: DNA Damage, Cellular Senescence in Health and Disease

Authors: Laura Neidernhofer

Year: 2020

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igaa057.2657

Paper Epigenetics: The Many Faces of Epigenetics in Aging

S. Berger · 2020 · Innovation in aging · DOI

Full title: Epigenetics: The Many Faces of Epigenetics in Aging

Authors: S. Berger

Year: 2020

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igaa057.2659

Paper Cellular Senescence and Mammalian Healthspan

J. Campisi · 2020 · Innovation in aging · DOI

Full title: Cellular Senescence and Mammalian Healthspan

Authors: J. Campisi

Year: 2020

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igaa057.2655

Paper Understanding and targeting senescence in kidney disease.

Chanvillard, Lucie; Mason, Tilly; Ferenbach, David A · 2025 · Clinical kidney journal · DOI

Full title: Understanding and targeting senescence in kidney disease.

Authors: Chanvillard, Lucie; Mason, Tilly; Ferenbach, David A

Year: 2025

Venue: Clinical kidney journal

DOI: https://doi.org/10.1093/ckj/sfaf190

Paper Drugs Targeting Mechanisms of Aging to Delay Age-Related Disease and Promote Healthspan: Proceedings of a National Institute on Aging Workshop.

S. Espinoza; S. Khosla; J. Baur et al. · 2023 · The journals of gerontology. Series A, Biological sciences and medical sciences · DOI

Full title: Drugs Targeting Mechanisms of Aging to Delay Age-Related Disease and Promote Healthspan: Proceedings of a National Institute on Aging Workshop.

Authors: S. Espinoza; S. Khosla; J. Baur; R. de Cabo; N. Musi

Year: 2023

Venue: The journals of gerontology. Series A, Biological sciences and medical sciences

DOI: https://doi.org/10.1093/gerona/glad034

Paper Targeting Cellular Senescence in Cancer, Health and Disease

Daohong Zhou · 2020 · Innovation in aging · DOI

Full title: Targeting Cellular Senescence in Cancer, Health and Disease

Authors: Daohong Zhou

Year: 2020

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igaa057.2658

Paper Mitochondrial Dysfunction and Cellular Senescence Due to Aging Contributes to Prostatic Fibrosis

Liu, Teresa; Ricke, Emily A.; Defranco, Donald et al. · 2020 · Innovation in Aging · DOI

Full title: Mitochondrial Dysfunction and Cellular Senescence Due to Aging Contributes to Prostatic Fibrosis

Authors: Liu, Teresa; Ricke, Emily A.; Defranco, Donald; Ricke, William A.

Year: 2020

Venue: Innovation in Aging

DOI: https://doi.org/10.1093/geroni/igaa057.439

Paper Pharmacological Interventions That Target Biological Aging

M. Kaeberlein · 2020 · Innovation in aging · DOI

Full title: Pharmacological Interventions That Target Biological Aging

Authors: M. Kaeberlein

Year: 2020

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igaa057.2980

Paper Epigenetics of Human Neurodegeneration

S. Berger · 2020 · Innovation in aging · DOI

Full title: Epigenetics of Human Neurodegeneration

Authors: S. Berger

Year: 2020

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igaa057.2660

Paper Aging, Senescent Cells, and Senolytic Drugs: The Path to Translation

J. Kirkland · 2020 · Innovation in aging · DOI

Full title: Aging, Senescent Cells, and Senolytic Drugs: The Path to Translation

Authors: J. Kirkland

Year: 2020

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igaa057.3198

Paper IDENTIFYING SENOLYTIC TARGETS OF DIETARY FLAVONOIDS IN RENAL CELLS BY THERMAL PROTEOME PROFILING

Quinn Strassheim; R. Banarjee; Delaney V Rutherford et al. · 2023 · Innovation in aging · DOI

Full title: IDENTIFYING SENOLYTIC TARGETS OF DIETARY FLAVONOIDS IN RENAL CELLS BY THERMAL PROTEOME PROFILING

Authors: Quinn Strassheim; R. Banarjee; Delaney V Rutherford; Amit K Dey; Dimitrios Tsitsipatis; R. Moaddel; Myriam Gorospe; N. Basisty

Year: 2023

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igad104.2997

Paper Senescence and Its Role in Fibrosis

C. Saux · 2020 · Innovation in aging · DOI

Full title: Senescence and Its Role in Fibrosis

Authors: C. Saux

Year: 2020

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igaa057.2699

Paper Senescence and Senolytics: State of the Art on Cellular Senescence, Senolytics, and Healthspan

J. Campisi · 2020 · Innovation in aging · DOI

Full title: Senescence and Senolytics: State of the Art on Cellular Senescence, Senolytics, and Healthspan

Authors: J. Campisi

Year: 2020

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igaa057.2654

Paper Targeting Senescent Cells to Counter Aging and Aging-Related Conditions

N. LeBrasseur · 2020 · Innovation in aging · DOI

Full title: Targeting Senescent Cells to Counter Aging and Aging-Related Conditions

Authors: N. LeBrasseur

Year: 2020

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igaa057.2981

Paper FUCOIDANS ARE NOVEL SENOTHERAPEUTICS THAT ENHANCE SIRT6 AND DNA REPAIR ACTIVITY

Lei Zhang; Brian Hughes; Greg Tombline et al. · 2022 · Innovation in aging · DOI

Full title: FUCOIDANS ARE NOVEL SENOTHERAPEUTICS THAT ENHANCE SIRT6 AND DNA REPAIR ACTIVITY

Authors: Lei Zhang; Brian Hughes; Greg Tombline; Luise A Angelini; Matt Yousefzadeh; Vera Gorbunova; Laura J. Niedernhofer; Paul D. Robbins

Year: 2022

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igac059.2666

Paper TRIALS AND TRIBULATIONS OF CONDUCTING A GEROSCIENCE TRIAL

Courtney L. Millar; Kathryn Baldyga; Ike Iloputaife et al. · 2023 · Innovation in aging · DOI

Full title: TRIALS AND TRIBULATIONS OF CONDUCTING A GEROSCIENCE TRIAL

Authors: Courtney L. Millar; Kathryn Baldyga; Ike Iloputaife; Alex Wolfe; Jasmin Kuo; Lewis A. Lipsitz

Year: 2023

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igad104.3673

Paper DNA Damage: Epigenetics, Aging and Rejuvenation

D. Sinclair · 2020 · Innovation in aging · DOI

Full title: DNA Damage: Epigenetics, Aging and Rejuvenation

Authors: D. Sinclair

Year: 2020

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igaa057.2662

Paper SENOLYTIC DRUGS: DISCOVERY, TRANSLATION, AND APPLICATION

N. LeBrasseur · 2019 · Innovation in aging · DOI

Full title: SENOLYTIC DRUGS: DISCOVERY, TRANSLATION, AND APPLICATION

Authors: N. LeBrasseur

Year: 2019

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igz038.2730

Paper SENOLYTIC EFFECTS ON COGNITION, MOBILITY, AND BIOMARKERS IN OLDER ADULTS WITH MCI AND SLOW GAIT: A PILOT STUDY

Courtney L. Millar; Ike Iloputaife; Kathryn Baldyga et al. · 2024 · Innovation in aging · DOI

Full title: SENOLYTIC EFFECTS ON COGNITION, MOBILITY, AND BIOMARKERS IN OLDER ADULTS WITH MCI AND SLOW GAIT: A PILOT STUDY

Authors: Courtney L. Millar; Ike Iloputaife; Kathryn Baldyga; Amani M. Norling; Afroditi Boulougoura; Theodoros Vichos; Tamara Tchkonia; Jim Kirkland

Year: 2024

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igae098.3709

Paper The Translational Geroscience Network: Supporting a New Paradigm to Alleviate Age-Related Chronic Disease

J. Justice; S. Kritchevsky; G. Kuchel et al. · 2020 · Innovation in aging · DOI

Full title: The Translational Geroscience Network: Supporting a New Paradigm to Alleviate Age-Related Chronic Disease

Authors: J. Justice; S. Kritchevsky; G. Kuchel; J. Kirkland

Year: 2020

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igaa057.3042

Paper P-337 A novel senotherapeutic strategy with azithromycin for preventing endometriosis progression

R. Sonehara; T. Nakamura; N. Miyake et al. · 2025 · Human Reproduction · DOI

Full title: P-337 A novel senotherapeutic strategy with azithromycin for preventing endometriosis progression

Authors: R. Sonehara; T. Nakamura; N. Miyake; A. Muraoka; S. Osuka; H. Kajiyama

Year: 2025

Venue: Human Reproduction

DOI: https://doi.org/10.1093/humrep/deaf097.645

Paper Therapeutic strategies targeting cellular senescence for cancer and other diseases

Xuebing Wang; Takeshi Fukumoto; Ken-ichi Noma · 2024 · Journal of Biochemistry (Tokyo) · DOI

Full title: Therapeutic strategies targeting cellular senescence for cancer and other diseases

Authors: Xuebing Wang; Takeshi Fukumoto; Ken-ichi Noma

Year: 2024

Venue: Journal of Biochemistry (Tokyo)

DOI: https://doi.org/10.1093/jb/mvae015

Paper ORALLY ACTIVE, CLINICALLY TRANSLATABLE SENOLYTICS RESTORE Α-KLOTHO IN MICE AND HUMANS

Yi Zhu; L. Prata; E. Gerdes et al. · 2022 · Innovation in aging · DOI

Full title: ORALLY ACTIVE, CLINICALLY TRANSLATABLE SENOLYTICS RESTORE Α-KLOTHO IN MICE AND HUMANS

Authors: Yi Zhu; L. Prata; E. Gerdes; J. Netto; T. Pirtskhalava; N. Giorgadze; Utkarsh Tripathi; C. Inman

Year: 2022

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igac059.2660

Paper DEVELOPMENT OF EPIGENETIC MEASURES FOR GEROSCIENCE CLINICAL TRIALS

M. Levine · 2019 · Innovation in aging · DOI

Full title: DEVELOPMENT OF EPIGENETIC MEASURES FOR GEROSCIENCE CLINICAL TRIALS

Authors: M. Levine

Year: 2019

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igz038.2732

Paper The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions

Secomandi, Laura E.; Borghesan, Michela; Velarde, Michael C. et al. · 2021 · Human Reproduction Update · DOI

Full title: The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions

Authors: Secomandi, Laura E.; Borghesan, Michela; Velarde, Michael C.; Demaria, Marco

Year: 2021

Venue: Human Reproduction Update

DOI: https://doi.org/10.1093/humupd/dmab038

Paper Cellular senescence in the cancer microenvironment.

Meguro, Satoru; Nakanishi, Makoto · 2025 · Journal of biochemistry · DOI

Full title: Cellular senescence in the cancer microenvironment.

Authors: Meguro, Satoru; Nakanishi, Makoto

Year: 2025

Venue: Journal of biochemistry

DOI: https://doi.org/10.1093/jb/mvaf001

Paper Macrophage Senescence: A New Axis in Inflammaging and MASLD with Implications for Senolytic Therapy

Anthony Covarubbias · 2025 · Innovation in aging · DOI

Full title: Macrophage Senescence: A New Axis in Inflammaging and MASLD with Implications for Senolytic Therapy

Authors: Anthony Covarubbias

Year: 2025

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igaf122.818

Paper Functional diversity of senescent cells in driving ageing phenotypes and facilitating tissue regeneration.

Nakano, Yasuhiro; Johmura, Yoshikazu · 2025 · Journal of biochemistry · DOI

Full title: Functional diversity of senescent cells in driving ageing phenotypes and facilitating tissue regeneration.

Authors: Nakano, Yasuhiro; Johmura, Yoshikazu

Year: 2025

Venue: Journal of biochemistry

DOI: https://doi.org/10.1093/jb/mvae098

Paper Clinical Trials of Senolytics in Alzheimer’s Disease Treatment and Prevention

Miranda Orr · 2025 · Innovation in aging · DOI

Full title: Clinical Trials of Senolytics in Alzheimer’s Disease Treatment and Prevention

Authors: Miranda Orr

Year: 2025

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igaf122.1102

Paper SENOTHERAPEUTICS, AGING, AND AGE-RELATED DISEASES

Dean Kellogg · 2024 · Innovation in aging · DOI

Full title: SENOTHERAPEUTICS, AGING, AND AGE-RELATED DISEASES

Authors: Dean Kellogg

Year: 2024

Venue: Innovation in aging

DOI: https://doi.org/10.1093/geroni/igae098.1474

Paper Brain Cell Senescence: A New Therapeutic Target for the Acute Treatment of Ischemic Stroke.

Júlia Baixauli-Martín; Alicia Aliena-Valero; M. Castelló-Ruiz et al. · 2022 · Journal of Neuropathology and Experimental Neurology · DOI

Full title: Brain Cell Senescence: A New Therapeutic Target for the Acute Treatment of Ischemic Stroke.

Authors: Júlia Baixauli-Martín; Alicia Aliena-Valero; M. Castelló-Ruiz; M. C. Burguete; M. A. López-Morales; D. Muñoz‐Espín; G. Torregrosa; J. Salom

Year: 2022

Venue: Journal of Neuropathology and Experimental Neurology

DOI: https://doi.org/10.1093/jnen/nlac048

Paper Endometrial receptivity in women of advanced age: an underrated factor in infertility.

Pathare, Amruta D S; Loid, Marina; Saare, Merli et al. · 2023 · Human reproduction update · DOI

Full title: Endometrial receptivity in women of advanced age: an underrated factor in infertility.

Authors: Pathare, Amruta D S; Loid, Marina; Saare, Merli; Gidlöf, Sebastian Brusell; Zamani Esteki, Masoud; Acharya, Ganesh; Peters, Maire; Salumets, Andres

Year: 2023

Venue: Human reproduction update

DOI: https://doi.org/10.1093/humupd/dmad019

Paper The Role of Cellular Senescence in Wound Healing of Diabetic Skin.

Ueda, Naohiro; Saito, Yuki; Ota, Katsunori et al. · 2026 · Journal of biochemistry · DOI

Full title: The Role of Cellular Senescence in Wound Healing of Diabetic Skin.

Authors: Ueda, Naohiro; Saito, Yuki; Ota, Katsunori; Nagao, Ayaka; Kasseki, Dain; Chikenji, Takako S

Year: 2026

Venue: Journal of biochemistry

DOI: https://doi.org/10.1093/jb/mvag006

Paper Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging.

Sun, Yu; Li, Qingfeng; Kirkland, James L · 2022 · Life medicine · DOI

Full title: Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging.

Authors: Sun, Yu; Li, Qingfeng; Kirkland, James L

Year: 2022

Venue: Life medicine

DOI: https://doi.org/10.1093/lifemedi/lnac030

Paper A comparative study of metformin and nicotinamide riboside in alleviating tissue aging in rats

Geng, Lingling; Zhang, Bin; Liu, Haisong et al. · 2022 · Life Medicine · DOI

Full title: A comparative study of metformin and nicotinamide riboside in alleviating tissue aging in rats

Authors: Geng, Lingling; Zhang, Bin; Liu, Haisong; Wang, Si; Cai, Yusheng; Yang, Kuan; Zou, Zhiran; Jiang, Xiaoyu; Liu, Zunpeng; Li, Wei; Wu, Zeming; Liu, Xiaoqian; Chu, Qun; Liu, Guang‐Hui; Qu, Jing; Zhang, Weiqi

Year: 2022

Venue: Life Medicine

DOI: https://doi.org/10.1093/lifemedi/lnac045

Paper Inflammatory cytokines secreted from senescent periodontal ligament cells influence the osteocyte network in alveolar bone.

Yamashita, Akimi; Tenshin, Hirofumi; Matsuki, SooHa et al. · 2026 · JBMR plus · DOI

Full title: Inflammatory cytokines secreted from senescent periodontal ligament cells influence the osteocyte network in alveolar bone.

Authors: Yamashita, Akimi; Tenshin, Hirofumi; Matsuki, SooHa; Nishino, Go; Ser-Od, Shinetsetseg; Saito, Filippo Moenne; Hiasa, Masahiro; Tanaka, Eiji

Year: 2026

Venue: JBMR plus

DOI: https://doi.org/10.1093/jbmrpl/ziag014

Paper CAR-T cells leave the comfort zone: current and future applications beyond cancer

Mazzi, Mariana Torres; Hajdu, Karina Lôbo; Ribeiro, Priscila Rafaela et al. · 2020 · Immunotherapy Advances · DOI

Full title: CAR-T cells leave the comfort zone: current and future applications beyond cancer

Authors: Mazzi, Mariana Torres; Hajdu, Karina Lôbo; Ribeiro, Priscila Rafaela; Bonamino, Martín

Year: 2020

Venue: Immunotherapy Advances

DOI: https://doi.org/10.1093/immadv/ltaa006

Paper LGG-03. EXPLORING THE SIGNALING NETWORK INVOLVED IN MAPK PATHWAY INHIBITION BY THE MEK INHIBITOR TRAMETINIB IN BRAF-FUSION-DRIVEN PEDIATRIC PILOCYTIC ASTROCYTOMA

· 2023 · Neuro-Oncology · DOI

Full title: LGG-03. EXPLORING THE SIGNALING NETWORK INVOLVED IN MAPK PATHWAY INHIBITION BY THE MEK INHIBITOR TRAMETINIB IN BRAF-FUSION-DRIVEN PEDIATRIC PILOCYTIC ASTROCYTOMA

Year: 2023

Venue: Neuro-Oncology

DOI: https://doi.org/10.1093/neuonc/noad073.213

Paper Understanding senescence in clonal hematopoiesis 2837

Inés Fernández Maestre; Matthew Wereski; Stéphane Van Haver et al. · 2025 · Journal of Immunology · DOI

Full title: Understanding senescence in clonal hematopoiesis 2837

Authors: Inés Fernández Maestre; Matthew Wereski; Stéphane Van Haver; Ana Leda; Figueiredo Longhini; Jayna Mistry; Jennifer Trowbridge; Ross Levine; Corina Amor

Year: 2025

Venue: Journal of Immunology

DOI: https://doi.org/10.1093/jimmun/vkaf283.712

Paper Inhibition of PERK-mediated unfolded protein response acts as a switch for reversal of residual senescence and as senolytic therapy in glioblastoma.

Ketkar, Madhura; Desai, Sanket; Rana, Pranav et al. · 2024 · Neuro-oncology · DOI

Full title: Inhibition of PERK-mediated unfolded protein response acts as a switch for reversal of residual senescence and as senolytic therapy in glioblastoma.

Authors: Ketkar, Madhura; Desai, Sanket; Rana, Pranav; Thorat, Rahul; Epari, Sridhar; Dutt, Amit; Dutt, Shilpee

Year: 2024

Venue: Neuro-oncology

DOI: https://doi.org/10.1093/neuonc/noae134

Paper LGG-27. Molecular implications of mitogen-activated protein kinase pathway inhibition by the MEK inhibitor trametinib in BRAF-fusion-driven pediatric pilocytic astrocytoma

Romain Sigaud; A. Stefanski; F. Selt et al. · 2022 · Neuro-Oncology · DOI

Full title: LGG-27. Molecular implications of mitogen-activated protein kinase pathway inhibition by the MEK inhibitor trametinib in BRAF-fusion-driven pediatric pilocytic astrocytoma

Authors: Romain Sigaud; A. Stefanski; F. Selt; T. Hielscher; D. Usta; Daniela Kocher; D. Picard; Isabel Büdenbender; M. Remke; S. Pfister; David C. Jones; T. Brummer; O. Witt; T. Milde

Year: 2022

Venue: Neuro-Oncology

DOI: https://doi.org/10.1093/neuonc/noac079.341

Paper - **DOI:** 10.1093/neuonc/noad179.0155 - **Authors:** Isha Mondal, Oishika Das, R. Lu, Winson S Ho - **Year:** 2023 - **Journal:** Neuro-Oncology

Isha Mondal; Oishika Das; R. Lu et al. · 2023 · Neuro-Oncology · DOI

Full title: - **DOI:** 10.1093/neuonc/noad179.0155 - **Authors:** Isha Mondal, Oishika Das, R. Lu, Winson S Ho - **Year:** 2023 - **Journal:** Neuro-Oncology

Authors: Isha Mondal; Oishika Das; R. Lu; Winson S Ho

Year: 2023

Venue: Neuro-Oncology

DOI: https://doi.org/10.1093/neuonc/noad179.0155

Paper Cellular senescence of granulosa cells in the pathogenesis of polycystic ovary syndrome

Tsurugi Tanaka; Y. Urata; M. Harada et al. · 2024 · Molecular human reproduction · DOI

Full title: Cellular senescence of granulosa cells in the pathogenesis of polycystic ovary syndrome

Authors: Tsurugi Tanaka; Y. Urata; M. Harada; C. Kunitomi; A. Kusamoto; H. Koike; Zixin Xu; Nanoka Sakaguchi; Chihiro Tsuchida; Airi Komura; Ayaka Teshima; Nozomi Takahashi; O. Wada-Hiraike; Y. Hirota; Yutaka Osuga

Year: 2024

Venue: Molecular human reproduction

DOI: https://doi.org/10.1093/molehr/gaae015

Paper DDDR-34. Bcl-xL inhibition enhances the efficacy of Temozolomide by targeting senescent glioblastoma cells

Fumi Higuchi; Juri Kiyokawa; Masahiro Shin et al. · 2025 · Neuro-Oncology · DOI

Full title: DDDR-34. Bcl-xL inhibition enhances the efficacy of Temozolomide by targeting senescent glioblastoma cells

Authors: Fumi Higuchi; Juri Kiyokawa; Masahiro Shin; Keisuke Ueki; D. Cahill; Hiroaki Wakimoto

Year: 2025

Venue: Neuro-Oncology

DOI: https://doi.org/10.1093/neuonc/noaf201.0671

Paper #2330 Fisetin supplement ameliorates aging related changes in the kidney

P. Fu; Qian Ren; Hui Li et al. · 2024 · Nephrology, Dialysis and Transplantation · DOI

Full title: #2330 Fisetin supplement ameliorates aging related changes in the kidney

Authors: P. Fu; Qian Ren; Hui Li; Liang Ma

Year: 2024

Venue: Nephrology, Dialysis and Transplantation

DOI: https://doi.org/10.1093/ndt/gfae069.708

Paper Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy.

Prasanna, Pataje G; Citrin, Deborah E; Hildesheim, Jeffrey et al. · 2021 · Journal of the National Cancer Institute · DOI

Full title: Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy.

Authors: Prasanna, Pataje G; Citrin, Deborah E; Hildesheim, Jeffrey; Ahmed, Mansoor M; Venkatachalam, Sundar; Riscuta, Gabriela; Xi, Dan; Zheng, Guangrong; Deursen, Jan van; Goronzy, Jorg; Kron, Stephen J; Anscher, Mitchell S; Sharpless, Norman E; Campisi, Judith; Brown, Stephen L; Niedernhofer, Laura J; O'Loghlen, Ana; Georgakilas, Alexandros G; Paris, Francois; Gius, David; Gewirtz, David A; Schmitt, Clemens A; Abazeed, Mohamed E; Kirkland, James L; Richmond, Ann; Romesser, Paul B; Lowe, Scott W; Gil, Jesus; Mendonca, Marc S; Burma, Sandeep; Zhou, Daohong; Coleman, C Norman

Year: 2021

Venue: Journal of the National Cancer Institute

DOI: https://doi.org/10.1093/jnci/djab064

Paper - **DOI:** 10.1093/neuonc/noz175.1054 - **Authors:** Eliot Fletcher-Sananikone, B. Mukherjee, S. Burma - **Year:** 2019 - **Journal:** Neuro-Oncology

Eliot Fletcher-Sananikone; B. Mukherjee; S. Burma · 2019 · Neuro-Oncology · DOI

Full title: - **DOI:** 10.1093/neuonc/noz175.1054 - **Authors:** Eliot Fletcher-Sananikone, B. Mukherjee, S. Burma - **Year:** 2019 - **Journal:** Neuro-Oncology

Authors: Eliot Fletcher-Sananikone; B. Mukherjee; S. Burma

Year: 2019

Venue: Neuro-Oncology

DOI: https://doi.org/10.1093/neuonc/noz175.1054

Paper LGG-14. INTEGRATED MULTI-OMICS EXPLORATION OF MAPK PATHWAY INHIBITION IN PEDIATRIC PILOCYTIC ASTROCYTOMA

Romain Sigaud; A. Stefanski; F. Selt et al. · 2024 · Neuro-Oncology · DOI

Full title: LGG-14. INTEGRATED MULTI-OMICS EXPLORATION OF MAPK PATHWAY INHIBITION IN PEDIATRIC PILOCYTIC ASTROCYTOMA

Authors: Romain Sigaud; A. Stefanski; F. Selt; D. Usta; Daniela Kocher; D. Picard; Isabel Büdenbender; Marc Remke; Stefan M. Pfister; David T. W. Jones; Tilman Brummer; Olaf Witt; T. Milde

Year: 2024

Venue: Neuro-Oncology

DOI: https://doi.org/10.1093/neuonc/noae064.407

Paper Research Progress of Flavonoids Regulating Endothelial Function

Li, Hao; Zhang, Qi · 2023 · Pharmaceuticals · DOI

Full title: Research Progress of Flavonoids Regulating Endothelial Function

Authors: Li, Hao; Zhang, Qi

Year: 2023

Venue: Pharmaceuticals

DOI: https://doi.org/10.3390/ph16091201

Paper Recent Advances in Potential Health Benefits of Quercetin

Aghababaei, Fatemeh; Hadidi, Milad · 2023 · Pharmaceuticals · DOI

Full title: Recent Advances in Potential Health Benefits of Quercetin

Authors: Aghababaei, Fatemeh; Hadidi, Milad

Year: 2023

Venue: Pharmaceuticals

DOI: https://doi.org/10.3390/ph16071020

Paper Effects of Fisetin, a Plant-Derived Flavonoid, on Response to Oxidative Stress, Aging, and Age-Related Diseases in Caenorhabditis elegans

Park, Su-Hyeon; Kim, Bo-Kyoung; Park, Sang-Kyu · 2022 · Pharmaceuticals · DOI

Full title: Effects of Fisetin, a Plant-Derived Flavonoid, on Response to Oxidative Stress, Aging, and Age-Related Diseases in Caenorhabditis elegans

Authors: Park, Su-Hyeon; Kim, Bo-Kyoung; Park, Sang-Kyu

Year: 2022

Venue: Pharmaceuticals

DOI: https://doi.org/10.3390/ph15121528

Paper Challenges in the Vaccination of the Elderly and Strategies for Improvement

Soegiarto, Gatot; Purnomosari, Dewajani · 2023 · Pathophysiology · DOI

Full title: Challenges in the Vaccination of the Elderly and Strategies for Improvement

Authors: Soegiarto, Gatot; Purnomosari, Dewajani

Year: 2023

Venue: Pathophysiology

DOI: https://doi.org/10.3390/pathophysiology30020014

Paper Mechanistic Analysis of Fisetin in Liver Diseases and Its Potential Therapeutic Application in IFALD-A Review of In Vitro and In Vivo Studies.

Belka, Marta; Stawny, Maciej; Masternak, Michal M et al. · 2025 · Nutrients · DOI

Full title: Mechanistic Analysis of Fisetin in Liver Diseases and Its Potential Therapeutic Application in IFALD-A Review of In Vitro and In Vivo Studies.

Authors: Belka, Marta; Stawny, Maciej; Masternak, Michal M; Krajka-Kuźniak, Violetta

Year: 2025

Venue: Nutrients

DOI: https://doi.org/10.3390/nu18010102

Paper Immunomodulatory Activity of the Tyrosine Kinase Inhibitor Dasatinib to Elicit NK Cytotoxicity against Cancer, HIV Infection and Aging

Rodríguez-Agustín, Andrea; Casanova, Víctor; Grau-Expósito, Judith et al. · 2023 · Pharmaceutics · DOI

Full title: Immunomodulatory Activity of the Tyrosine Kinase Inhibitor Dasatinib to Elicit NK Cytotoxicity against Cancer, HIV Infection and Aging

Authors: Rodríguez-Agustín, Andrea; Casanova, Víctor; Grau-Expósito, Judith; Sánchez‐Palomino, Sonsoles; Alcamı́, José; Climent, Núria

Year: 2023

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics15030917

Paper Targeting Mitochondria to Control Ageing and Senescence

Protasoni, Margherita; Serrano, Manuel · 2023 · Pharmaceutics · DOI

Full title: Targeting Mitochondria to Control Ageing and Senescence

Authors: Protasoni, Margherita; Serrano, Manuel

Year: 2023

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics15020352

Paper Network Pharmacology and Machine Learning Identify Flavonoids as Potential Senotherapeutics

Jose Alberto Santiago-de-la-Cruz; N. A. Rivero-Segura; M. Álvarez-Sánchez et al. · 2025 · Pharmaceuticals · DOI

Full title: Network Pharmacology and Machine Learning Identify Flavonoids as Potential Senotherapeutics

Authors: Jose Alberto Santiago-de-la-Cruz; N. A. Rivero-Segura; M. Álvarez-Sánchez; J. C. Gómez-Verjan

Year: 2025

Venue: Pharmaceuticals

DOI: https://doi.org/10.3390/ph18081176

Paper Cellular Senescence in Health, Disease, and Lens Aging.

Qin, Ying; Liu, Haoxin; Wu, Hongli · 2025 · Pharmaceuticals (Basel, Switzerland) · DOI

Full title: Cellular Senescence in Health, Disease, and Lens Aging.

Authors: Qin, Ying; Liu, Haoxin; Wu, Hongli

Year: 2025

Venue: Pharmaceuticals (Basel, Switzerland)

DOI: https://doi.org/10.3390/ph18020244

Paper Curcumin-like Compound Inhibits Proliferation of Adenocarcinoma Cells by Inducing Cell Cycle Arrest and Senescence.

Fonseca, Rafael; Louzano, Yasmin Dos Santos; Ortiz, Cindy Juliet Cristancho et al. · 2025 · Pharmaceuticals (Basel, Switzerland) · DOI

Full title: Curcumin-like Compound Inhibits Proliferation of Adenocarcinoma Cells by Inducing Cell Cycle Arrest and Senescence.

Authors: Fonseca, Rafael; Louzano, Yasmin Dos Santos; Ortiz, Cindy Juliet Cristancho; Silva, Matheus de Freitas; Felix, Maria Luiza Vieira; Ferreira-Silva, Guilherme Álvaro; Caixeta, Ester Siqueira; Zavan, Bruno; Viegas, Claudio; Ionta, Marisa

Year: 2025

Venue: Pharmaceuticals (Basel, Switzerland)

DOI: https://doi.org/10.3390/ph18060914

Paper The Potential of Polyphenols in Modulating the Cellular Senescence Process: Implications and Mechanism of Action.

Della Vedova, Larissa; Baron, Giovanna; Morazzoni, Paolo et al. · 2025 · Pharmaceuticals (Basel, Switzerland) · DOI

Full title: The Potential of Polyphenols in Modulating the Cellular Senescence Process: Implications and Mechanism of Action.

Authors: Della Vedova, Larissa; Baron, Giovanna; Morazzoni, Paolo; Aldini, Giancarlo; Gado, Francesca

Year: 2025

Venue: Pharmaceuticals (Basel, Switzerland)

DOI: https://doi.org/10.3390/ph18020138

Paper Researching New Drug Combinations with Senolytic Activity Using Senescent Human Lung Fibroblasts MRC-5 Cell Line

Maria Carolina Ximenes de Godoy; Juliana Alves Macedo; Alessandra Gambero · 2024 · Pharmaceuticals · DOI

Full title: Researching New Drug Combinations with Senolytic Activity Using Senescent Human Lung Fibroblasts MRC-5 Cell Line

Authors: Maria Carolina Ximenes de Godoy; Juliana Alves Macedo; Alessandra Gambero

Year: 2024

Venue: Pharmaceuticals

DOI: https://doi.org/10.3390/ph17010070

Paper Senescent Cells in Early Vascular Ageing and Bone Disease of Chronic Kidney Disease-A Novel Target for Treatment.

Hobson, Sam; Arefin, Samsul; Kublickiene, Karolina et al. · 2019 · Toxins · DOI

Full title: Senescent Cells in Early Vascular Ageing and Bone Disease of Chronic Kidney Disease-A Novel Target for Treatment.

Authors: Hobson, Sam; Arefin, Samsul; Kublickiene, Karolina; Shiels, Paul G; Stenvinkel, Peter

Year: 2019

Venue: Toxins

DOI: https://doi.org/10.3390/toxins11020082

Paper Inflammation and Premature Ageing in Chronic Kidney Disease

Ebert, Thomas; Pawelzik, Sven‐Christian; Witasp, Anna et al. · 2020 · Toxins · DOI

Full title: Inflammation and Premature Ageing in Chronic Kidney Disease

Authors: Ebert, Thomas; Pawelzik, Sven‐Christian; Witasp, Anna; Arefin, Samsul; Hobson, Sam; Kublickiene, Karolina; Shiels, Paul G.; Bäck, Magnus; Stenvinkel, Peter

Year: 2020

Venue: Toxins

DOI: https://doi.org/10.3390/toxins12040227

Paper Targeting Senescent Cells as Therapy for CKD.

Mylonas, Katie J; Ferenbach, David A · 2024 · Kidney360 · DOI

Full title: Targeting Senescent Cells as Therapy for CKD.

Authors: Mylonas, Katie J; Ferenbach, David A

Year: 2024

Venue: Kidney360

DOI: https://doi.org/10.34067/KID.0000000000000316

Paper Senolytic Vaccines from the Central and Peripheral Tolerance Perspective

Vasilieva, Maria; Shatalova, Rimma O.; Matveeva, K. S. et al. · 2024 · Vaccines · DOI

Full title: Senolytic Vaccines from the Central and Peripheral Tolerance Perspective

Authors: Vasilieva, Maria; Shatalova, Rimma O.; Matveeva, K. S.; Shindyapin, Vadim V.; Minskaia, Ekaterina; Ivanov, Roman; Shevyrev, Daniil

Year: 2024

Venue: Vaccines

DOI: https://doi.org/10.3390/vaccines12121389

Paper The Occurrence of Senescence in the Arteriovenous Fistula in the Rat.

Nath, Karl A; Juncos, Luis A; Singh, Raman Deep et al. · 2025 · Kidney360 · DOI

Full title: The Occurrence of Senescence in the Arteriovenous Fistula in the Rat.

Authors: Nath, Karl A; Juncos, Luis A; Singh, Raman Deep; Grande, Joseph P; Croatt, Anthony J; Ackerman, Allan W; Kanamori, Karina S; Adams, Christopher M; Tchkonia, Tamara; Kirkland, James L; Katusic, Zvonimir S

Year: 2025

Venue: Kidney360

DOI: https://doi.org/10.34067/KID.0000000605

Paper Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models

Seokmuk Park; Seyeol Baek; Hee-Jae Shin et al. · 2025 · Pharmaceutics · DOI

Full title: Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models

Authors: Seokmuk Park; Seyeol Baek; Hee-Jae Shin; Jeong Yi Hwang; Dae Sung Yoo; Dae Bang Seo; Seunghee Bae

Year: 2025

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics17121560

Paper Natural Products Acting as Senolytics and Senomorphics Alleviate Cardiovascular Diseases by Targeting Senescent Cells

Hejing Tang; Xu Zhang; Senyang Hu et al. · 2025 · TARGETS · DOI

Full title: Natural Products Acting as Senolytics and Senomorphics Alleviate Cardiovascular Diseases by Targeting Senescent Cells

Authors: Hejing Tang; Xu Zhang; Senyang Hu; Yuhan Song; Wenhua Jin; Jianmin Zou; Yan Zhang; Jiayue Guo; Peng An; Junjie Luo; Pengjie Wang; Yongting Luo; Yinhua Zhu

Year: 2025

Venue: TARGETS

DOI: https://doi.org/10.3390/targets3030023

Paper Senescence and SASP Are Potential Therapeutic Targets for Ischemic Stroke

Blake Ouvrier; Saifudeen Ismael; G. Bix · 2024 · Pharmaceuticals · DOI

Full title: Senescence and SASP Are Potential Therapeutic Targets for Ischemic Stroke

Authors: Blake Ouvrier; Saifudeen Ismael; G. Bix

Year: 2024

Venue: Pharmaceuticals

DOI: https://doi.org/10.3390/ph17030312

Paper The effect of dihydroquercetin therapy on clinical status and the burden of senescent cells in elderly patients with chronic heart failure: rationale and study design

I. S. Daudov; A. G. Plisyuk; R. A. Abramovich et al. · 2025 · Russian Journal of Geriatric Medicine · DOI

Full title: The effect of dihydroquercetin therapy on clinical status and the burden of senescent cells in elderly patients with chronic heart failure: rationale and study design

Authors: I. S. Daudov; A. G. Plisyuk; R. A. Abramovich; O. G. Potanina; A. G. Klementeva; Z. A. Akopyan; A. Efimenko; Y. Orlova

Year: 2025

Venue: Russian Journal of Geriatric Medicine

DOI: https://doi.org/10.37586/2686-8636-2-2025-225-227

Paper Senescence-Induced Atherosclerosis: The Potency of Senolytic Therapy

Udani Sari Ratih; F. C. Iswanti · 2024 · Bioscientia Medicina : Journal of Biomedicine and Translational Research · DOI

Full title: Senescence-Induced Atherosclerosis: The Potency of Senolytic Therapy

Authors: Udani Sari Ratih; F. C. Iswanti

Year: 2024

Venue: Bioscientia Medicina : Journal of Biomedicine and Translational Research

DOI: https://doi.org/10.37275/bsm.v8i8.1036

Paper Age-dependent trends in adverse reactions of SARS-CoV-2 vaccines: A narrative review

Laiba Noor; Syeda Momna Ishtiaq; Farhat Batool et al. · 2024 · AIMS Allergy and Immunology · DOI

Full title: Age-dependent trends in adverse reactions of SARS-CoV-2 vaccines: A narrative review

Authors: Laiba Noor; Syeda Momna Ishtiaq; Farhat Batool; Muhammad Imran Arshad

Year: 2024

Venue: AIMS Allergy and Immunology

DOI: https://doi.org/10.3934/allergy.2024008

Paper Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity.

Mukherjee, Gargi; Mitra, Abhishek; Joshi, Vrinda et al. · 2025 · Journal of visualized experiments : JoVE · DOI

Full title: Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity.

Authors: Mukherjee, Gargi; Mitra, Abhishek; Joshi, Vrinda; Chowdhury, Goutam; Chakrabarty, Anindita

Year: 2025

Venue: Journal of visualized experiments : JoVE

DOI: https://doi.org/10.3791/68725

Paper The Science of Aging: Therapeutic Approaches to Extend Lifespan and Healthspan

M. M. Praveena · 2025 · SBV Journal of Basic, Clinical and Applied Health Science · DOI

Full title: The Science of Aging: Therapeutic Approaches to Extend Lifespan and Healthspan

Authors: M. M. Praveena

Year: 2025

Venue: SBV Journal of Basic, Clinical and Applied Health Science

DOI: https://doi.org/10.4103/sbvj.sbvj_11_25

Paper A Prospectively Created Living Organoid Biobank of Crohn’s Disease Patients Enables Integrative Therapeutics

Gajanan D. Katkar; C. Tindle; Ayden G. Fonseca et al. · 2022 · Journal of Immunology · DOI

Full title: A Prospectively Created Living Organoid Biobank of Crohn’s Disease Patients Enables Integrative Therapeutics

Authors: Gajanan D. Katkar; C. Tindle; Ayden G. Fonseca; Sahar Taheri; Jasper Lee; I. Sayed; Stella-Rita C. Ibeawuchi; Pranadinata Rama; MacKenzie Fuller; Dominik L. Stec; Mahitha Shree Anandachar; Vanae Goheen-Holland; Jason Ear; B. Boland; W. Sandborn; D. Sahoo; Soumita Das; P. Ghosh

Year: 2022

Venue: Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.208.supp.115.22

Paper Senotherapeutics and Their Molecular Mechanism for Improving Aging.

Park, Jooho; Shin, Dong Wook · 2022 · Biomolecules & therapeutics · DOI

Full title: Senotherapeutics and Their Molecular Mechanism for Improving Aging.

Authors: Park, Jooho; Shin, Dong Wook

Year: 2022

Venue: Biomolecules & therapeutics

DOI: https://doi.org/10.4062/biomolther.2022.114

Paper Potential of natural senolytic compounds in eliminating senescent cells and alleviating age-related skin deterioration: a narrative review

G. A. Ramirez; T. Viel · 2024 · Aging Advances · DOI

Full title: Potential of natural senolytic compounds in eliminating senescent cells and alleviating age-related skin deterioration: a narrative review

Authors: G. A. Ramirez; T. Viel

Year: 2024

Venue: Aging Advances

DOI: https://doi.org/10.4103/agingadv.agingadv-d-24-00014

Paper - **Authors:** P. Torres, R. Pamplona, M. Portero-Otín - **Year:** 2023 - **Journal:** Neural Regeneration Research - **Source:** semanticscholar

P. Torres; R. Pamplona; M. Portero-Otín · 2023 · Neural Regeneration Research · DOI

Full title: - **Authors:** P. Torres, R. Pamplona, M. Portero-Otín - **Year:** 2023 - **Journal:** Neural Regeneration Research - **Source:** semanticscholar

Authors: P. Torres; R. Pamplona; M. Portero-Otín

Year: 2023

Venue: Neural Regeneration Research

DOI: https://doi.org/10.4103/1673-5374.363832

Paper Epidermal Growth Factor Therapy Impact on Scar Tissue Resilience of Diabetic Lower Limbs Ulcers-An Enlightening Hypothesis

Acosta, Jorge Berlanga; Mendoza‐Marí, Yssel; García‐Ojalvo, Ariana et al. · 2018 · Journal of Diabetes & Metabolism · DOI

Full title: Epidermal Growth Factor Therapy Impact on Scar Tissue Resilience of Diabetic Lower Limbs Ulcers-An Enlightening Hypothesis

Authors: Acosta, Jorge Berlanga; Mendoza‐Marí, Yssel; García‐Ojalvo, Ariana; Fernández‐Mayola, Maday; Nieto, Gerardo Guillen

Year: 2018

Venue: Journal of Diabetes & Metabolism

DOI: https://doi.org/10.4172/2155-6156.1000798

Paper Cardiac glycosides: Looking beyond heart failure and atrial fibrillation

Joseph G Omole; G. Udom; Ayodeji Aturamu et al. · 2025 · Indian Journal of Pharmacology · DOI

Full title: Cardiac glycosides: Looking beyond heart failure and atrial fibrillation

Authors: Joseph G Omole; G. Udom; Ayodeji Aturamu; R. D. Agbana; O. Aziakpono; B. Oritsemuelebi; Sarad Pawar Naik Bukke; I. Okon; O. Yemitan

Year: 2025

Venue: Indian Journal of Pharmacology

DOI: https://doi.org/10.4103/ijp.ijp_934_24

Paper The New Frontier of Ageing: Innovations and Insights in Gerontology

Tohit, Nor Faiza Mohd; Haque, Mainul · 2024 · Advances in Human Biology · DOI

Full title: The New Frontier of Ageing: Innovations and Insights in Gerontology

Authors: Tohit, Nor Faiza Mohd; Haque, Mainul

Year: 2024

Venue: Advances in Human Biology

DOI: https://doi.org/10.4103/aihb.aihb_110_24

Paper Dysfunctional stem and progenitor cells impair fracture healing with age

Wagner, Diane R.; Karnik, Sonali; Gunderson, Zachary J. et al. · 2019 · World Journal of Stem Cells · DOI

Full title: Dysfunctional stem and progenitor cells impair fracture healing with age

Authors: Wagner, Diane R.; Karnik, Sonali; Gunderson, Zachary J.; Nielsen, Jeffery J.; Fennimore, Alanna; Promer, Hunter J; Lowery, Jonathan W.; Loghmani, M. Terry; Low, Philip S.; McKinley, Todd O.; Kacena, Melissa A.; Clauss, Matthias; Li, Jiliang

Year: 2019

Venue: World Journal of Stem Cells

DOI: https://doi.org/10.4252/wjsc.v11.i6.281

Paper Epigenetic Modifications and Cellular Senescence: A Critical Review

Sarah Salih Hasan; H. A. Shubbar · 2025 · Cognizance Journal of Multidisciplinary Studies · DOI

Full title: Epigenetic Modifications and Cellular Senescence: A Critical Review

Authors: Sarah Salih Hasan; H. A. Shubbar

Year: 2025

Venue: Cognizance Journal of Multidisciplinary Studies

DOI: https://doi.org/10.47760/cognizance.2025.v05i09.007

Paper SENOLYTICS AND SENOMORPHICS: A NEW CLASS OF DRUGS FOR ANTI-AGING THERAPY

T. Saliev; Prim B. Singh · 2025 · Central Asian Journal of Medical Hypotheses and Ethics · DOI

Full title: SENOLYTICS AND SENOMORPHICS: A NEW CLASS OF DRUGS FOR ANTI-AGING THERAPY

Authors: T. Saliev; Prim B. Singh

Year: 2025

Venue: Central Asian Journal of Medical Hypotheses and Ethics

DOI: https://doi.org/10.47316/cajmhe.2025.6.3.01

Paper Moving from an “anti-aging” paradigm toward the concept of “disease-free aging”: the role of senolytics in modern medicine

Iván Aprahamian; Andréia Pain; Virgílio Garcia Moreira · 2024 · Geriatrics Gerontology and Aging · DOI

Full title: Moving from an “anti-aging” paradigm toward the concept of “disease-free aging”: the role of senolytics in modern medicine

Authors: Iván Aprahamian; Andréia Pain; Virgílio Garcia Moreira

Year: 2024

Venue: Geriatrics Gerontology and Aging

DOI: https://doi.org/10.53886/gga.e0000240_en

Paper Cellular senescence, aging, and age-related disease: Special issue of BMB Reports in 2019.

Lee, Jae-Seon · 2019 · BMB reports · DOI

Full title: Cellular senescence, aging, and age-related disease: Special issue of BMB Reports in 2019.

Authors: Lee, Jae-Seon

Year: 2019

Venue: BMB reports

DOI: https://doi.org/10.5483/BMBRep.2019.52.1.002

Paper Senotherapeutics: emerging strategy for healthy aging and age-related disease

Kim, Eok-Cheon; Kim, Jae‐Ryong · 2019 · BMB Reports · DOI

Full title: Senotherapeutics: emerging strategy for healthy aging and age-related disease

Authors: Kim, Eok-Cheon; Kim, Jae‐Ryong

Year: 2019

Venue: BMB Reports

DOI: https://doi.org/10.5483/bmbrep.2019.52.1.293

Paper IPF and CPFE—The Two Different Entities or Two Different Presentations of the Same Disease?

Kwiatkowska, Sylwia · 2017 · Advances in respiratory medicine · DOI

Full title: IPF and CPFE—The Two Different Entities or Two Different Presentations of the Same Disease?

Authors: Kwiatkowska, Sylwia

Year: 2017

Venue: Advances in respiratory medicine

DOI: https://doi.org/10.5603/arm.a2017.0049

Paper Senolytics And Their Effects On Various Diseases

Kübra Danış Oruç; Ayşe Gül Mutlu · 2024 · Turkish journal of health science and life · DOI

Full title: Senolytics And Their Effects On Various Diseases

Authors: Kübra Danış Oruç; Ayşe Gül Mutlu

Year: 2024

Venue: Turkish journal of health science and life

DOI: https://doi.org/10.56150/tjhsl.1345120

Paper Molecular and cellular drivers of inflammaging: Uncovering the diverse mechanisms and interventions of inflammaging

Joris Van de Walle; Thibaut Delvaux; Arnaud Vandenberghe · 2025 · Clinical and translational reports · DOI

Full title: Molecular and cellular drivers of inflammaging: Uncovering the diverse mechanisms and interventions of inflammaging

Authors: Joris Van de Walle; Thibaut Delvaux; Arnaud Vandenberghe

Year: 2025

Venue: Clinical and translational reports

DOI: https://doi.org/10.58832/ctr.2025.10.9.2

Paper Exploring the Evolution of Senotherapeutics Across Generations: A New Era in Human Dermal Fibroblast Senotherapy

S. Farokhimanesh · 2025 · Journal of Skin and Stem Cell · DOI

Full title: Exploring the Evolution of Senotherapeutics Across Generations: A New Era in Human Dermal Fibroblast Senotherapy

Authors: S. Farokhimanesh

Year: 2025

Venue: Journal of Skin and Stem Cell

DOI: https://doi.org/10.5812/jssc-159836

Paper Senescence of endplate osteoclasts induces sensory innervation and spinal pain

Pan, Dayu; Benkato, Kheiria Gamal; Han, Xuequan et al. · 2023 · eLife · DOI

Full title: Senescence of endplate osteoclasts induces sensory innervation and spinal pain

Authors: Pan, Dayu; Benkato, Kheiria Gamal; Han, Xuequan; Zheng, Jinjian; Kumar, Vijay; Wan, Mei; Zheng, Junying; Cao, Xu

Year: 2023

Venue: eLife

DOI: https://doi.org/10.1096/fasebj.2020.34.s1.00428

Paper Osteoporosis Treatment: Not Easy

S. Ott · 2023 · Annals of Internal Medicine · DOI

Full title: Osteoporosis Treatment: Not Easy

Authors: S. Ott

Year: 2023

Venue: Annals of Internal Medicine

DOI: https://doi.org/10.7326/m22-3580

Paper CSIG-02. RADIATION-INDUCED SENESCENCE AS A DRIVER OF GLIOBLASTOMA RECURRENCE

Bipasha Mukherjee; Lorena Samentar; Suman Kanji et al. · 2025 · Neuro-Oncology · DOI

Full title: CSIG-02. RADIATION-INDUCED SENESCENCE AS A DRIVER OF GLIOBLASTOMA RECURRENCE

Authors: Bipasha Mukherjee; Lorena Samentar; Suman Kanji; John R Floyd; S. Burma

Year: 2025

Venue: Neuro-Oncology

DOI: https://doi.org/10.1093/neuonc/noaf201.0336

Paper The ageing immune system as a potential target of senolytics

Du, Peter Yandi; Gandhi, Ankesh; Bawa, Manraj et al. · 2023 · Oxford Open Immunology · DOI

Full title: The ageing immune system as a potential target of senolytics

Authors: Du, Peter Yandi; Gandhi, Ankesh; Bawa, Manraj; Gromala, Justyna

Year: 2023

Venue: Oxford Open Immunology

DOI: https://doi.org/10.1093/oxfimm/iqad004

Paper Interventional Strategies to Delay Aging Related Diseases & Conditions of the Musculoskeletal System

J. Huard · 2020 · The FASEB Journal · DOI

Full title: Interventional Strategies to Delay Aging Related Diseases & Conditions of the Musculoskeletal System

Authors: J. Huard

Year: 2020

Venue: The FASEB Journal

Paper ET-6 Gemcitabine radiosensitization primes irradiated malignant meningioma cells for senolytic elimination by navitoclax

Masahiro Yamamoto; C. Kitanaka · 2021 · Neuro-Oncology Advances · DOI

Full title: ET-6 Gemcitabine radiosensitization primes irradiated malignant meningioma cells for senolytic elimination by navitoclax

Authors: Masahiro Yamamoto; C. Kitanaka

Year: 2021

Venue: Neuro-Oncology Advances

DOI: https://doi.org/10.1093/noajnl/vdab159.016

Paper Depletion of senescent cells improves surgery-induced neuroinflammation in aged mice

Sajeeshkumar Madhurakkat Perikamana; Hunter Newman; Yuru Vernon Shih et al. · 2025 · PNAS Nexus · DOI

Full title: Depletion of senescent cells improves surgery-induced neuroinflammation in aged mice

Authors: Sajeeshkumar Madhurakkat Perikamana; Hunter Newman; Yuru Vernon Shih; Lavonia Duncan; H. A. Rather; Jiaoni Li; Ravikanth Velagapudi; N. Terrando; Shyni Varghese

Year: 2025

Venue: PNAS Nexus

DOI: https://doi.org/10.1093/pnasnexus/pgaf103

Paper Fisetin Attenuates Cellular Senescence Accumulation During Culture Expansion of Human Adipose-Derived Stem Cells.

Mullen, Michael; Nelson, Anna Laura; Goff, Alexander et al. · 2023 · Stem cells (Dayton, Ohio) · DOI

Full title: Fisetin Attenuates Cellular Senescence Accumulation During Culture Expansion of Human Adipose-Derived Stem Cells.

Authors: Mullen, Michael; Nelson, Anna Laura; Goff, Alexander; Billings, Jake; Kloser, Heidi; Huard, Charles; Mitchell, John; Hambright, William Sealy; Ravuri, Sudheer; Huard, Johnny

Year: 2023

Venue: Stem cells (Dayton, Ohio)

DOI: https://doi.org/10.1093/stmcls/sxad036

Paper Stimulation of prostate cells by the senescence phenotype of epithelial and stromal cells: Implication for benign prostate hyperplasia

Jiang, Shoulei; Song, Chung S.; Chatterjee, Bandana · 2019 · FASEB BioAdvances · DOI

Full title: Stimulation of prostate cells by the senescence phenotype of epithelial and stromal cells: Implication for benign prostate hyperplasia

Authors: Jiang, Shoulei; Song, Chung S.; Chatterjee, Bandana

Year: 2019

Venue: FASEB BioAdvances

DOI: https://doi.org/10.1096/fba.2018-00084

Paper Cellular senescence in kidney diseases.

Wang, Xiaojie; Li, Yujia; Chu, Qingqing et al. · 2025 · Chinese medical journal · DOI

Full title: Cellular senescence in kidney diseases.

Authors: Wang, Xiaojie; Li, Yujia; Chu, Qingqing; Lv, Hang; Li, Jing; Yi, Fan

Year: 2025

Venue: Chinese medical journal

DOI: https://doi.org/10.1097/CM9.0000000000003746

Paper Senescence‐associated secretory phenotype promotes chronic ocular graft‐vs‐host disease in mice and humans

Mio Yamane; Shinri Sato; Eisuke Shimizu et al. · 2020 · The FASEB Journal · DOI

Full title: Senescence‐associated secretory phenotype promotes chronic ocular graft‐vs‐host disease in mice and humans

Authors: Mio Yamane; Shinri Sato; Eisuke Shimizu; S. Shibata; Motoshi Hayano; T. Yaguchi; H. Kamijuku; Mamoru Ogawa; Takanori Suzuki; S. Mukai; S. Shimmura; H. Okano; T. Takeuchi; Y. Kawakami; Y. Ogawa; K. Tsubota

Year: 2020

Venue: The FASEB Journal

DOI: https://doi.org/10.1096/fj.201900218r

Paper The senolytic drug fisetin mitigates age‐related bone density loss in the progeroid mouse model Zmpste24−/−

Sealy Hambright; Y. Kawakami; Xiaodong Mu et al. · 2020 · The FASEB Journal · DOI

Full title: The senolytic drug fisetin mitigates age‐related bone density loss in the progeroid mouse model Zmpste24−/−

Authors: Sealy Hambright; Y. Kawakami; Xiaodong Mu; Xueqin Gao; A. Lu; J. Kirkland; J. Huard

Year: 2020

Venue: The FASEB Journal

DOI: https://doi.org/10.1096/fasebj.2020.34.s1.06658

Paper Elimination of Senescent Cells Attenuates Obesity‐Induced Increase in Sympathetic Nerve Activity

M. Sivasubramanian; Raisa Monteiro; Priya Balasubramanian et al. · 2022 · The FASEB Journal · DOI

Full title: Elimination of Senescent Cells Attenuates Obesity‐Induced Increase in Sympathetic Nerve Activity

Authors: M. Sivasubramanian; Raisa Monteiro; Priya Balasubramanian; M. Subramanian

Year: 2022

Venue: The FASEB Journal

DOI: https://doi.org/10.1096/fasebj.2022.36.s1.r5988

Paper Procyanidin C1 inhibits bleomycin-induced pulmonary fibrosis in mice by selective clearance of senescent myofibroblasts.

Shao, Min; Qiu, Yujia; Shen, Mengxia et al. · 2024 · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · DOI

Full title: Procyanidin C1 inhibits bleomycin-induced pulmonary fibrosis in mice by selective clearance of senescent myofibroblasts.

Authors: Shao, Min; Qiu, Yujia; Shen, Mengxia; Liu, Wei; Feng, Dandan; Luo, Ziqiang; Zhou, Yan

Year: 2024

Venue: FASEB journal : official publication of the Federation of American Societies for Experimental Biology

DOI: https://doi.org/10.1096/fj.202302547RR

Paper Controlled induction and targeted elimination of p16INK4a‐expressing chondrocytes in cartilage explant culture

G. Sessions; M. Copp; Jie-Yu Liu et al. · 2019 · The FASEB Journal · DOI

Full title: Controlled induction and targeted elimination of p16INK4a‐expressing chondrocytes in cartilage explant culture

Authors: G. Sessions; M. Copp; Jie-Yu Liu; M. Sinkler; S. D’Costa; B. Diekman

Year: 2019

Venue: The FASEB Journal

DOI: https://doi.org/10.1096/fj.201900815rr

Paper Muscle injury induces a transient senescence‐like state that is required for myofiber growth during muscle regeneration

Laura V. Young; Griffen Wakelin; A. R. Cameron et al. · 2022 · The FASEB Journal · DOI

Full title: Muscle injury induces a transient senescence‐like state that is required for myofiber growth during muscle regeneration

Authors: Laura V. Young; Griffen Wakelin; A. R. Cameron; S. Springer; J. Ross; Grant Wolters; J. P. Murphy; Michel G. Arsenault; Sean Y Ng; Nicolás Collao; M. De Lisio; Vladimir Ljubicic; Adam P W Johnston

Year: 2022

Venue: The FASEB Journal

DOI: https://doi.org/10.1096/fj.202200289rr

Paper Navigating the complex role of senescence in liver disease.

Li, Qiuting; Wang, Lin · 2024 · Chinese medical journal · DOI

Full title: Navigating the complex role of senescence in liver disease.

Authors: Li, Qiuting; Wang, Lin

Year: 2024

Venue: Chinese medical journal

DOI: https://doi.org/10.1097/CM9.0000000000003439

Paper Senolytic Drugs, Dasatinib and Quercetin, Attenuate Adipose Tissue T Lymphocyte Infiltration and Improve Metabolic Function in Old Mice

M. Islam; Eric Tuday; John Kim et al. · 2021 · The FASEB Journal · DOI

Full title: Senolytic Drugs, Dasatinib and Quercetin, Attenuate Adipose Tissue T Lymphocyte Infiltration and Improve Metabolic Function in Old Mice

Authors: M. Islam; Eric Tuday; John Kim; T. Dutson; Tam T. T. Phuong; A. Donato; L. Lesniewski

Year: 2021

Venue: The FASEB Journal

DOI: https://doi.org/10.1096/fasebj.2021.35.s1.01969

Paper Senolytic procyanidin C1 alleviates renal fibrosis by promoting apoptosis of senescent renal tubular epithelial cells.

Gan, Yu; Wang, Kangning; Chen, Xiang et al. · 2025 · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · DOI

Full title: Senolytic procyanidin C1 alleviates renal fibrosis by promoting apoptosis of senescent renal tubular epithelial cells.

Authors: Gan, Yu; Wang, Kangning; Chen, Xiang; Li, Yong; He, Yao; Zhou, Yan; Zhang, Bo

Year: 2025

Venue: FASEB journal : official publication of the Federation of American Societies for Experimental Biology

DOI: https://doi.org/10.1096/fj.202402558R

Paper Wound healing: cellular mechanisms and pathological outcomes

Wilkinson, Holly N.; Hardman, Matthew J. · 2020 · Open Biology · DOI

Full title: Wound healing: cellular mechanisms and pathological outcomes

Authors: Wilkinson, Holly N.; Hardman, Matthew J.

Year: 2020

Venue: Open Biology

DOI: https://doi.org/10.1098/rsob.200223

Paper Nutrition senolytics - illusion or reality for cognitive ageing?

Xi Sophie Chen; H. Brodaty; F. O’Leary · 2021 · Current opinion in clinical nutrition and metabolic care · DOI

Full title: Nutrition senolytics - illusion or reality for cognitive ageing?

Authors: Xi Sophie Chen; H. Brodaty; F. O’Leary

Year: 2021

Venue: Current opinion in clinical nutrition and metabolic care

DOI: https://doi.org/10.1097/mco.0000000000000796

Paper Cellular senescence in renal ischemia-reperfusion injury.

Chen, Ying; Yang, Li · 2025 · Chinese medical journal · DOI

Full title: Cellular senescence in renal ischemia-reperfusion injury.

Authors: Chen, Ying; Yang, Li

Year: 2025

Venue: Chinese medical journal

DOI: https://doi.org/10.1097/CM9.0000000000003698

Paper Human umbilical cord mesenchymal stem cells-derived extracellular vesicles ameliorate kidney ischemia-reperfusion injury by suppression of senescent tubular epithelial cells: experimental study.

Ma, Ming; Zeng, Jun; Zhu, Mengli et al. · 2025 · International journal of surgery (London, England) · DOI

Full title: Human umbilical cord mesenchymal stem cells-derived extracellular vesicles ameliorate kidney ischemia-reperfusion injury by suppression of senescent tubular epithelial cells: experimental study.

Authors: Ma, Ming; Zeng, Jun; Zhu, Mengli; Li, Hui; Lin, Tao; Yang, Hao; Wei, Xin; Song, Turun

Year: 2025

Venue: International journal of surgery (London, England)

DOI: https://doi.org/10.1097/JS9.0000000000002074

Paper Chronic HIV Infection and Aging: Application of a Geroscience-Guided Approach.

Masters, Mary C; Landay, Alan L; Robbins, Paul D et al. · 2022 · Journal of acquired immune deficiency syndromes (1999) · DOI

Full title: Chronic HIV Infection and Aging: Application of a Geroscience-Guided Approach.

Authors: Masters, Mary C; Landay, Alan L; Robbins, Paul D; Tchkonia, Tamar; Kirkland, James L; Kuchel, George A; Niedernhofer, Laura J; Palella, Frank J

Year: 2022

Venue: Journal of acquired immune deficiency syndromes (1999)

DOI: https://doi.org/10.1097/QAI.0000000000002858

Paper Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence.

Li, Caizhen; Shen, Yanting; Huang, Liuwei et al. · 2021 · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · DOI

Full title: Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence.

Authors: Li, Caizhen; Shen, Yanting; Huang, Liuwei; Liu, Chongbin; Wang, Jun

Year: 2021

Venue: FASEB journal : official publication of the Federation of American Societies for Experimental Biology

DOI: https://doi.org/10.1096/fj.202001855RR

Paper Induction of Cellular Senescence in Rat Vaginal Fibroblasts and Treatment With Senolytics: An in Vitro Model for the Study of Pelvic Organ Prolapse

Maria E. Florian-Rodriguez; A. Hare; Neha G Gaddam et al. · 2022 · Female Pelvic Medicine & Reconstructive Surgery · DOI

Full title: Induction of Cellular Senescence in Rat Vaginal Fibroblasts and Treatment With Senolytics: An in Vitro Model for the Study of Pelvic Organ Prolapse

Authors: Maria E. Florian-Rodriguez; A. Hare; Neha G Gaddam; Haolin Shi; Patrick W. Keller; R. Word

Year: 2022

Venue: Female Pelvic Medicine & Reconstructive Surgery

DOI: https://doi.org/10.1097/spv.0000000000001131

Paper Targeting Cellular Senescence for Age-Related Diseases: Path to Clinical Translation.

Wyles, Saranya P; Tchkonia, Tamara; Kirkland, James L · 2022 · Plastic and reconstructive surgery · DOI

Full title: Targeting Cellular Senescence for Age-Related Diseases: Path to Clinical Translation.

Authors: Wyles, Saranya P; Tchkonia, Tamara; Kirkland, James L

Year: 2022

Venue: Plastic and reconstructive surgery

DOI: https://doi.org/10.1097/PRS.0000000000009669

Paper From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs.

L'Hôte, Valentin; Mann, Carl; Thuret, Jean-Yves · 2022 · Open biology · DOI

Full title: From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs.

Authors: L'Hôte, Valentin; Mann, Carl; Thuret, Jean-Yves

Year: 2022

Venue: Open biology

DOI: https://doi.org/10.1098/rsob.220171

Paper Senescence in pulmonary arterial hypertension: is there a link?

Semen, Khrystyna O; Bast, Aalt · 2022 · Current opinion in pulmonary medicine · DOI

Full title: Senescence in pulmonary arterial hypertension: is there a link?

Authors: Semen, Khrystyna O; Bast, Aalt

Year: 2022

Venue: Current opinion in pulmonary medicine

DOI: https://doi.org/10.1097/MCP.0000000000000879

Paper Ageing, cellular senescence and chronic kidney disease: experimental evidence.

Tan, Huishi; Xu, Jie; Liu, Youhua · 2022 · Current opinion in nephrology and hypertension · DOI

Full title: Ageing, cellular senescence and chronic kidney disease: experimental evidence.

Authors: Tan, Huishi; Xu, Jie; Liu, Youhua

Year: 2022

Venue: Current opinion in nephrology and hypertension

DOI: https://doi.org/10.1097/MNH.0000000000000782

Paper Targeting Cellular Senescence with Senotherapeutics: Development of New Approaches for Skin Care

Elizabeth L Thompson; Louise E. Pitcher; L. Niedernhofer et al. · 2021 · Plastic and Reconstructive Surgery · DOI

Full title: Targeting Cellular Senescence with Senotherapeutics: Development of New Approaches for Skin Care

Authors: Elizabeth L Thompson; Louise E. Pitcher; L. Niedernhofer; P. Robbins

Year: 2021

Venue: Plastic and Reconstructive Surgery

DOI: https://doi.org/10.1097/prs.0000000000009668

Paper Research Highlights

Barbas, Andrew S.; Luo, Xunrong; Thorp, Edward B. et al. · 2020 · Transplantation · DOI

Full title: Research Highlights

Authors: Barbas, Andrew S.; Luo, Xunrong; Thorp, Edward B.; Luo, Xunrong

Year: 2020

Venue: Transplantation

DOI: https://doi.org/10.1097/tp.0000000000003396

Paper Senotherapeutic peptide reduces skin biological age and improves skin health markers

Zonari, Alessandra; Brace, Lear E.; Al-Katib, Kallie et al. · 2020 · DOI

Full title: Senotherapeutic peptide reduces skin biological age and improves skin health markers

Authors: Zonari, Alessandra; Brace, Lear E.; Al-Katib, Kallie; Porto, William F.; Foyt, Daniel; Guiang, Mylieneth; Cruz, Edgar Andrés Ochoa; Marshall, Bailey; Salgueiro, Willian Goulart; Inan, Mehmet Dinçer; Rahman, Mizanur; Anupom, Taslim; Vanapalli, Siva A.; Mori, Marcelo A.; Franco, Octávio Luiz; Oliveira, Carolina R.; Boroni, Mariana; Carvalho, Juliana Lott

Year: 2020

DOI: https://doi.org/10.1101/2020.10.30.362822

Paper Sexual dimorphic metabolic and cognitive responses of C57BL/6 mice to Fisetin or Dasatinib and quercetin cocktail oral treatment

Yimin Fang; David X. Medina; R. Stockwell et al. · 2021 · bioRxiv · DOI

Full title: Sexual dimorphic metabolic and cognitive responses of C57BL/6 mice to Fisetin or Dasatinib and quercetin cocktail oral treatment

Authors: Yimin Fang; David X. Medina; R. Stockwell; Samuel McFadden; Kathleen Quinn; M. R. Peck; A. Bartke; K. Hascup; Erin R. Hascup

Year: 2021

Venue: bioRxiv

DOI: https://doi.org/10.1007/s11357-023-00843-0

Paper Death-seq identifies regulators of cell death and senolytic therapies

Colville, Alex; Liu, Jie‐Yu; Thomas, Samantha M. et al. · 2022 · DOI

Full title: Death-seq identifies regulators of cell death and senolytic therapies

Authors: Colville, Alex; Liu, Jie‐Yu; Thomas, Samantha M.; Ishak, Heather D.; Zhou, Ronghao; Klein, Julian D.D.; Morgens, David W.; Goshayeshi, Armon; Salvi, Jayesh S.; Yao, David; Spees, Kaitlyn; Bassik, Michael C.; Rando, Thomas A.

Year: 2022

DOI: https://doi.org/10.1101/2022.04.01.486768

Paper Targeting YAP-mediated HSC death susceptibility and senescence for treatment of liver fibrosis.

Du, Kuo; Maeso-Díaz, Raquel; Oh, Seh Hoon et al. · 2023 · Hepatology (Baltimore, Md.) · DOI

Full title: Targeting YAP-mediated HSC death susceptibility and senescence for treatment of liver fibrosis.

Authors: Du, Kuo; Maeso-Díaz, Raquel; Oh, Seh Hoon; Wang, Ergang; Chen, Tianyi; Pan, Christopher; Xiang, Kun; Dutta, Rajesh Kumar; Wang, Xiao-Fan; Chi, Jen-Tsan; Diehl, Anna Mae

Year: 2023

Venue: Hepatology (Baltimore, Md.)

DOI: https://doi.org/10.1097/HEP.0000000000000326

Paper Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress.

Venkatasubramanian, Ravinandan; Darrah, Mary A; Mahoney, Sophia A et al. · 2025 · Hypertension (Dallas, Tex. : 1979) · DOI

Full title: Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress.

Year: 2025

Venue: Hypertension (Dallas, Tex. : 1979)

DOI: https://doi.org/10.1161/HYPERTENSIONAHA.125.25408

Paper Targeting senescent cells with NKG2D-CAR T cells

Yushuang Deng; Avadh Kumar; Kan Xie et al. · 2024 · Cell Death Discovery · DOI

Full title: Targeting senescent cells with NKG2D-CAR T cells

Authors: Yushuang Deng; Avadh Kumar; Kan Xie; Kristina Schaaf; Enzo Scifo; Sarah Morsy; Tao Li; Armin Ehninger; Daniele Bano; D. Ehninger

Year: 2024

Venue: Cell Death Discovery

DOI: https://doi.org/10.1038/s41420-024-01976-7

Paper A renal clearable fluorogenic probe for in vivo β-galactosidase activity detection during aging and senolysis

Rojas-Vázquez, Sara; Lozano‐Torres, Beatriz; García‐Fernández, Alba et al. · 2024 · Nature Communications · DOI

Full title: A renal clearable fluorogenic probe for in vivo β-galactosidase activity detection during aging and senolysis

Authors: Rojas-Vázquez, Sara; Lozano‐Torres, Beatriz; García‐Fernández, Alba; Galiana, Irene; Pérez‐Villalba, Ana; Martí‐Rodrigo, Pablo; Palop, M. José; Domínguez, Marcia; Orzáez, Mar; Sancenón, Félix; Blandez, Juan F.; Fariñas, Isabel; Martínez‐Máñez, Ramón

Year: 2024

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-024-44903-1

Paper Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients' treatment.

Lelarge, V; Capelle, R; Oger, F et al. · 2024 · npj aging · DOI

Full title: Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients' treatment.

Authors: Lelarge, V; Capelle, R; Oger, F; Mathieu, T; Le Calvé, B

Year: 2024

Venue: npj aging

DOI: https://doi.org/10.1038/s41514-024-00138-4

Paper Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models

Zonari, Alessandra; Brace, Lear E.; Al-Katib, Kallie et al. · 2023 · npj Aging · DOI

Full title: Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models

Authors: Zonari, Alessandra; Brace, Lear E.; Al-Katib, Kallie; Porto, William F.; Foyt, Daniel; Guiang, Mylieneth; Cruz, Edgar Andrés Ochoa; Marshall, Bailey; Gentz, Melissa; Guimarães, Gabriela; Franco, Octávio Luiz; Oliveira, Carolina R.; Boroni, Mariana; Carvalho, Juliana Lott

Year: 2023

Venue: npj Aging

DOI: https://doi.org/10.1038/s41514-023-00109-1

Paper The role of cellular senescence in ageing and endocrine disease.

Khosla, Sundeep; Farr, Joshua N; Tchkonia, Tamara et al. · 2020 · Nature reviews. Endocrinology · DOI

Full title: The role of cellular senescence in ageing and endocrine disease.

Authors: Khosla, Sundeep; Farr, Joshua N; Tchkonia, Tamara; Kirkland, James L

Year: 2020

Venue: Nature reviews. Endocrinology

DOI: https://doi.org/10.1038/s41574-020-0335-y

Paper The quest to slow ageing through drug discovery

L. Partridge; M. Fuentealba; B. Kennedy · 2020 · Nature reviews. Drug discovery · DOI

Full title: The quest to slow ageing through drug discovery

Authors: L. Partridge; M. Fuentealba; B. Kennedy

Year: 2020

Venue: Nature reviews. Drug discovery

DOI: https://doi.org/10.1038/s41573-020-0067-7

Paper Mechanisms and therapeutic implications of cellular senescence in osteoarthritis.

Coryell, Philip R; Diekman, Brian O; Loeser, Richard F · 2021 · Nature reviews. Rheumatology · DOI

Full title: Mechanisms and therapeutic implications of cellular senescence in osteoarthritis.

Authors: Coryell, Philip R; Diekman, Brian O; Loeser, Richard F

Year: 2021

Venue: Nature reviews. Rheumatology

DOI: https://doi.org/10.1038/s41584-020-00533-7

Paper Cellular senescence and senolytics: the path to the clinic

Selim Chaib; T. Tchkonia; J. Kirkland · 2022 · Nature Medicine · DOI

Full title: Cellular senescence and senolytics: the path to the clinic

Authors: Selim Chaib; T. Tchkonia; J. Kirkland

Year: 2022

Venue: Nature Medicine

DOI: https://doi.org/10.1038/s41591-022-01923-y

Paper Senescence as a therapeutic target in cancer and age-related diseases

Domhnall McHugh; Imanol Durán; Jesús Gil · 2024 · Nature reviews. Drug discovery · DOI

Full title: Senescence as a therapeutic target in cancer and age-related diseases

Authors: Domhnall McHugh; Imanol Durán; Jesús Gil

Year: 2024

Venue: Nature reviews. Drug discovery

DOI: https://doi.org/10.1038/s41573-024-01074-4

Paper Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial.

Gonzales, Mitzi M; Garbarino, Valentina R; Kautz, Tiffany F et al. · 2023 · Nature medicine · DOI

Full title: Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial.

Authors: Gonzales, Mitzi M; Garbarino, Valentina R; Kautz, Tiffany F; Palavicini, Juan Pablo; Lopez-Cruzan, Marisa; Dehkordi, Shiva Kazempour; Mathews, Julia J; Zare, Habil; Xu, Peng; Zhang, Bin; Franklin, Crystal; Habes, Mohamad; Craft, Suzanne; Petersen, Ronald C; Tchkonia, Tamara; Kirkland, James L; Salardini, Arash; Seshadri, Sudha; Musi, Nicolas; Orr, Miranda E

Year: 2023

Venue: Nature medicine

DOI: https://doi.org/10.1038/s41591-023-02543-w

Paper Cellular senescence: the good, the bad and the unknown

Weijun Huang; L. Hickson; A. Eirin et al. · 2022 · Nature Reviews Nephrology · DOI

Full title: Cellular senescence: the good, the bad and the unknown

Authors: Weijun Huang; L. Hickson; A. Eirin; J. Kirkland; L. Lerman

Year: 2022

Venue: Nature Reviews Nephrology

DOI: https://doi.org/10.1038/s41581-022-00601-z

Paper Cellular senescence in ageing: from mechanisms to therapeutic opportunities.

Di Micco, Raffaella; Krizhanovsky, Valery; Baker, Darren et al. · 2021 · Nature reviews. Molecular cell biology · DOI

Full title: Cellular senescence in ageing: from mechanisms to therapeutic opportunities.

Authors: Di Micco, Raffaella; Krizhanovsky, Valery; Baker, Darren; d'Adda di Fagagna, Fabrizio

Year: 2021

Venue: Nature reviews. Molecular cell biology

DOI: https://doi.org/10.1038/s41580-020-00314-w

Paper Immunotherapy and senolytics in head and neck squamous cell carcinoma: phase 2 trial results.

Liu, Niu; Wu, Jiaying; Deng, Enze et al. · 2025 · Nature medicine · DOI

Full title: Immunotherapy and senolytics in head and neck squamous cell carcinoma: phase 2 trial results.

Authors: Liu, Niu; Wu, Jiaying; Deng, Enze; Zhong, Jianglong; Wei, Bin; Cai, Tingting; Xie, Zhijun; Duan, Xiaohui; Fu, Sha; Osei-Hwedieh, David O; Huang, Kezhi; Zhuang, Peilin; Sha, Ou; Chen, Yunsheng; Lv, Xiaobin; Zhu, Yingying; Zhang, Lizao; Lin, Hsinyu; Li, Qunxing; Lu, Peichia; Miao, Jiahao; Yamada, Teppei; Cai, Lei; Du, Hongwei; Baca, Sylvan C; Huang, Qingpei; Ferrone, Soldano; Wang, Xinhui; Xu, Fang; Fan, Xiaoying; Fan, Song

Year: 2025

Venue: Nature medicine

DOI: https://doi.org/10.1038/s41591-025-03873-7

Paper Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.

Crespo-Garcia, Sergio; Fournier, Frédérik; Diaz-Marin, Roberto et al. · 2024 · Nature medicine · DOI

Full title: Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.

Authors: Crespo-Garcia, Sergio; Fournier, Frédérik; Diaz-Marin, Roberto; Klier, Sharon; Ragusa, Derek; Masaki, Lauren; Cagnone, Gael; Blot, Guillaume; Hafiane, Ikhlas; Dejda, Agnieszka; Rizk, Rana; Juneau, Rachel; Buscarlet, Manuel; Chorfi, Sarah; Patel, Priyanka; Beltran, Pedro J; Joyal, Jean-Sebastien; Rezende, Flavio A; Hata, Masayuki; Nguyen, Alex; Sullivan, Lynne; Damiano, Jason; Wilson, Ariel M; Mallette, Frédérick A; David, Nathaniel E; Ghosh, Anirvan; Tsuruda, Pamela R; Dananberg, Jamie; Sapieha, Przemyslaw

Year: 2024

Venue: Nature medicine

DOI: https://doi.org/10.1038/s41591-024-02802-4

Paper The metabolic roots of senescence: mechanisms and opportunities for intervention.

Wiley, Christopher D; Campisi, Judith · 2021 · Nature metabolism · DOI

Full title: The metabolic roots of senescence: mechanisms and opportunities for intervention.

Authors: Wiley, Christopher D; Campisi, Judith

Year: 2021

Venue: Nature metabolism

DOI: https://doi.org/10.1038/s42255-021-00483-8

Paper Cardiac glycosides are broad-spectrum senolytics.

Guerrero, Ana; Herranz, Nicolás; Sun, Bin et al. · 2019 · Nature metabolism · DOI

Full title: Cardiac glycosides are broad-spectrum senolytics.

Authors: Guerrero, Ana; Herranz, Nicolás; Sun, Bin; Wagner, Verena; Gallage, Suchira; Guiho, Romain; Wolter, Katharina; Pombo, Joaquim; Irvine, Elaine E; Innes, Andrew J; Birch, Jodie; Glegola, Justyna; Manshaei, Saba; Heide, Danijela; Dharmalingam, Gopuraja; Harbig, Jule; Olona, Antoni; Behmoaras, Jacques; Dauch, Daniel; Uren, Anthony G; Zender, Lars; Vernia, Santiago; Martínez-Barbera, Juan Pedro; Heikenwalder, Mathias; Withers, Dominic J; Gil, Jesús

Year: 2019

Venue: Nature metabolism

DOI: https://doi.org/10.1038/s42255-019-0122-z

Paper A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice

Yang Yang; Natacha Jn-Simon; Yonghan He et al. · 2025 · Nature Aging · DOI

Full title: A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice

Authors: Yang Yang; Natacha Jn-Simon; Yonghan He; Chunbao Sun; Peiyi Zhang; Wanyi Hu; Tian Tian; Huadong Zeng; Sreenivasulu Basha; Araceli S. Huerta; Lu-Zhe Sun; X. Yin; R. Hromas; Guangrong Zheng; Liya Pi; Daohong Zhou

Year: 2025

Venue: Nature Aging

DOI: https://doi.org/10.1038/s43587-025-00811-7

Paper Strategies for targeting senescent cells in human disease

Nathan S. Gasek; G. Kuchel; J. Kirkland et al. · 2021 · Nature Aging · DOI

Full title: Strategies for targeting senescent cells in human disease

Authors: Nathan S. Gasek; G. Kuchel; J. Kirkland; Ming Xu

Year: 2021

Venue: Nature Aging

DOI: https://doi.org/10.1038/s43587-021-00121-8

Paper Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog

Magkouta, Sophia; Veroutis, Dimitris; Papaspyropoulos, Angelos et al. · 2024 · Nature Aging · DOI

Full title: Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog

Authors: Magkouta, Sophia; Veroutis, Dimitris; Papaspyropoulos, Angelos; Γεωργίου, Μαρία; Lougiakis, Nikolaos; Pippa, Νatassa; Havaki, Sophia; Palaiologou, Anastasia; Thanos, Dimitris-Foivos; Kambas, Konstantinos; Lаgopati, Nefeli; Boukos, Nikos; Pouli, Nicole; Marakos, Panagiotis; Kotsinas, Athanassios; Thanos, Dimitris; Evangelou, Konstantinos; Sampaziotis, Fotios; Tamvakopoulos, Constantin; Pispas, Stergios; Petty, Russell; Kotopoulos, Nicholas; Gorgoulis, Vassilis G.

Year: 2024

Venue: Nature Aging

DOI: https://doi.org/10.1038/s43587-024-00747-4

Paper Targeting the senescence-associated secretory phenotype to modify osteoarthritis in aging.

Afzal, Muhammad; Rekha, M M; Sahoo, Samir et al. · 2025 · Inflammopharmacology · DOI

Full title: Targeting the senescence-associated secretory phenotype to modify osteoarthritis in aging.

Authors: Afzal, Muhammad; Rekha, M M; Sahoo, Samir; Pandey, Surya Nath; Maji, Chandana; Goyal, Kavita; Ali, Haider; Singh, Sachin Kumar; Gupta, Gaurav; Hussain, Md Sadique

Year: 2025

Venue: Inflammopharmacology

DOI: https://doi.org/10.1007/s10787-025-02001-8

Paper Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease.

Nieto, Mario; Konigsberg, Mina; Silva-Palacios, Alejandro · 2024 · Biogerontology · DOI

Full title: Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease.

Authors: Nieto, Mario; Konigsberg, Mina; Silva-Palacios, Alejandro

Year: 2024

Venue: Biogerontology

DOI: https://doi.org/10.1007/s10522-023-10068-5

Paper Senotherapeutic repurposing of metformin for age-related diseases and their signaling pathways.

Turgut, Şeydanur; Atasever, Erdem; Cebe, Tamer et al. · 2025 · Molecular biology reports · DOI

Full title: Senotherapeutic repurposing of metformin for age-related diseases and their signaling pathways.

Authors: Turgut, Şeydanur; Atasever, Erdem; Cebe, Tamer; Andican, Gülnur; Çakatay, Ufuk

Year: 2025

Venue: Molecular biology reports

DOI: https://doi.org/10.1007/s11033-025-10524-0

Paper Cellular senescence in glioma.

Chojak, Rafał; Fares, Jawad; Petrosyan, Edgar et al. · 2023 · Journal of neuro-oncology · DOI

Full title: Cellular senescence in glioma.

Authors: Chojak, Rafał; Fares, Jawad; Petrosyan, Edgar; Lesniak, Maciej S

Year: 2023

Venue: Journal of neuro-oncology

DOI: https://doi.org/10.1007/s11060-023-04387-3

Paper Immunopharmacology of senescence: targeting the senescence-associated secretory phenotype (SASP)-a mechanism-based review.

Sahu, Poonam; Satapathy, Trilochan · 2025 · Inflammopharmacology · DOI

Full title: Immunopharmacology of senescence: targeting the senescence-associated secretory phenotype (SASP)-a mechanism-based review.

Authors: Sahu, Poonam; Satapathy, Trilochan

Year: 2025

Venue: Inflammopharmacology

DOI: https://doi.org/10.1007/s10787-025-01867-y

Paper Balancing senescence and apoptosis: therapeutic insights into aging and cancer.

Jan, Nusrat; Sofi, Shazia; Mir, Aijaz Ahmad et al. · 2025 · Molecular and cellular biochemistry · DOI

Full title: Balancing senescence and apoptosis: therapeutic insights into aging and cancer.

Authors: Jan, Nusrat; Sofi, Shazia; Mir, Aijaz Ahmad; Masoodi, Gowhar; Mir, Manzoor Ahmad

Year: 2025

Venue: Molecular and cellular biochemistry

DOI: https://doi.org/10.1007/s11010-025-05355-3

Paper Long-term dasatinib plus quercetin effects on aging outcomes and inflammation in nonhuman primates: implications for senolytic clinical trial design.

Ruggiero, Alistaire D; Vemuri, Ravichandra; Blawas, Megan et al. · 2023 · GeroScience · DOI

Full title: Long-term dasatinib plus quercetin effects on aging outcomes and inflammation in nonhuman primates: implications for senolytic clinical trial design.

Authors: Ruggiero, Alistaire D; Vemuri, Ravichandra; Blawas, Megan; Long, Masha; DeStephanis, Darla; Williams, Abigail G; Chen, Haiying; Justice, Jamie N; Macauley, Shannon L; Day, Steven M; Kavanagh, Kylie

Year: 2023

Venue: GeroScience

DOI: https://doi.org/10.1007/s11357-023-00830-5

Paper Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence

Ungvari, Anna; Kiss, Tamás; Gulej, Rafał et al. · 2024 · GeroScience · DOI

Full title: Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence

Authors: Ungvari, Anna; Kiss, Tamás; Gulej, Rafał; Tarantini, Stefano; Csík, Boglárka; Yabluchanskiy, Andriy; Mukli, Péter; Csiszár, Anna; Harris, Melissa L.; Ungvári, Zoltán

Year: 2024

Venue: GeroScience

DOI: https://doi.org/10.1007/s11357-023-01042-7

Paper Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

Harrison, David; Strong, Randy; Reifsnyder, Peter C. et al. · 2023 · GeroScience · DOI

Full title: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

Authors: Harrison, David; Strong, Randy; Reifsnyder, Peter C.; Rosenthal, Nadia; Korstanje, Ron; Fernández, Elizabeth; Flurkey, Kevin; Ginsburg, Brett C.; Murrell, Meredith D.; Javors, Martin A.; Lopez‐Cruzan, Marisa; Nelson, James F.; Willcox, Bradley J.; Allsopp, Richard; Watumull, D.; Watumull, David G.; Cortopassi, Gino; Kirkland, James L.; Tchkonia, Tamar; Choi, Young Geun; Yousefzadeh, Matthew J.; Robbins, Paul D.; Mitchell, James R.; Açar, Murat; Sarnoski, Ethan A.; Bene, Michael R.; Salmon, Adam B.; Kumar, Navasuja; Miller, Richard A.

Year: 2023

Venue: GeroScience

DOI: https://doi.org/10.1007/s11357-023-01011-0

Paper Targeting Cell Senescence for the Treatment of Age-Related Bone Loss.

Pignolo, Robert J; Samsonraj, Rebekah M; Law, Susan F et al. · 2019 · Current osteoporosis reports · DOI

Full title: Targeting Cell Senescence for the Treatment of Age-Related Bone Loss.

Authors: Pignolo, Robert J; Samsonraj, Rebekah M; Law, Susan F; Wang, Haitao; Chandra, Abhishek

Year: 2019

Venue: Current osteoporosis reports

DOI: https://doi.org/10.1007/s11914-019-00504-2

Paper The senolytic cocktail, dasatinib and quercetin, impacts the chromatin structure of both young and senescent vascular smooth muscle cells

Gadecka, Agnieszka; Nowak, Natalia; Bulanda, Edyta et al. · 2025 · GeroScience · DOI

Full title: The senolytic cocktail, dasatinib and quercetin, impacts the chromatin structure of both young and senescent vascular smooth muscle cells

Authors: Gadecka, Agnieszka; Nowak, Natalia; Bulanda, Edyta; Janiszewska, Dorota; Dudkowska, Magdalena; Sikora, Ewa; Bielak-Żmijewska, Anna

Year: 2025

Venue: GeroScience

DOI: https://doi.org/10.1007/s11357-024-01504-6

Paper Liver Regeneration: Polyploidy and Cellular Senescence as Potential Regulators.

Zare Jalise, Saeedeh; Habibi, Sina; Khosrowpour, Zahra et al. · 2026 · Stem cell reviews and reports · DOI

Full title: Liver Regeneration: Polyploidy and Cellular Senescence as Potential Regulators.

Authors: Zare Jalise, Saeedeh; Habibi, Sina; Khosrowpour, Zahra; Piryaei, Abbas; Hosseinzadeh, Faezeh; Navaei-Nigjeh, Mona; Fath-Bayati, Leyla

Year: 2026

Venue: Stem cell reviews and reports

DOI: https://doi.org/10.1007/s12015-025-11001-8

Paper The Second Euro Geroscience Conference: Highlights of the Current Advances and Challenges in the Field of Geroscience

Laetitia Lengelé · 2022 · The Journal of Nutrition, Health & Aging · DOI

Full title: The Second Euro Geroscience Conference: Highlights of the Current Advances and Challenges in the Field of Geroscience

Authors: Laetitia Lengelé

Year: 2022

Venue: The Journal of Nutrition, Health & Aging

DOI: https://doi.org/10.1007/s12603-022-1775-y

Paper Anti-aging Factor GRSF1 Attenuates Cerebral Ischemia-Reperfusion Injury in Mice by Inhibiting GPX4-Mediated Ferroptosis.

Li, Yanan; Shen, Qianni; Huang, Lidan et al. · 2024 · Molecular neurobiology · DOI

Full title: Anti-aging Factor GRSF1 Attenuates Cerebral Ischemia-Reperfusion Injury in Mice by Inhibiting GPX4-Mediated Ferroptosis.

Authors: Li, Yanan; Shen, Qianni; Huang, Lidan; Li, Bingyu; Zhang, Yuxi; Wang, Wei; Zhao, Bo; Gao, Wenwei

Year: 2024

Venue: Molecular neurobiology

DOI: https://doi.org/10.1007/s12035-023-03685-1

Paper Senolytics: The Modern Snake Oil?

J. Morley · 2019 · The Journal of Nutrition, Health & Aging · DOI

Full title: Senolytics: The Modern Snake Oil?

Authors: J. Morley

Year: 2019

Venue: The Journal of Nutrition, Health & Aging

DOI: https://doi.org/10.1007/s12603-019-1202-1

Paper Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion

Huanyin Tang; Anke Geng; Tengjiao Zhang et al. · 2018 · Protein & Cell · DOI

Full title: Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion

Authors: Huanyin Tang; Anke Geng; Tengjiao Zhang; Chen Wang; Ying Jiang; Z. Mao

Year: 2018

Venue: Protein & Cell

DOI: https://doi.org/10.1007/s13238-018-0591-y

Paper Antiaging agents: safe interventions to slow aging and healthy life span extension

Liu, Ji‐Kai · 2022 · Natural Products and Bioprospecting · DOI

Full title: Antiaging agents: safe interventions to slow aging and healthy life span extension

Authors: Liu, Ji‐Kai

Year: 2022

Venue: Natural Products and Bioprospecting

DOI: https://doi.org/10.1007/s13659-022-00339-y

Paper Potential Role of Polyphenolic Flavonoids as Senotherapeutic Agents in Degenerative Diseases and Geroprotection

Mbara, Kingsley Chimaeze; Devnarain, Nikita; Owira, Peter M. O. · 2022 · Pharmaceutical Medicine · DOI

Full title: Potential Role of Polyphenolic Flavonoids as Senotherapeutic Agents in Degenerative Diseases and Geroprotection

Authors: Mbara, Kingsley Chimaeze; Devnarain, Nikita; Owira, Peter M. O.

Year: 2022

Venue: Pharmaceutical Medicine

DOI: https://doi.org/10.1007/s40290-022-00444-w

Paper The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis.

Go, Seokhyeong; Kang, Mikyung; Kwon, Sung Pil et al. · 2021 · Tissue engineering and regenerative medicine · DOI

Full title: The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis.

Authors: Go, Seokhyeong; Kang, Mikyung; Kwon, Sung Pil; Jung, Mungyo; Jeon, Ok Hee; Kim, Byung-Soo

Year: 2021

Venue: Tissue engineering and regenerative medicine

DOI: https://doi.org/10.1007/s13770-021-00346-z

Paper Current and Future Treatment Landscape for Idiopathic Pulmonary Fibrosis

Bonella, Francesco; Spagnolo, Paolo; Ryerson, C.J. · 2023 · Drugs · DOI

Full title: Current and Future Treatment Landscape for Idiopathic Pulmonary Fibrosis

Authors: Bonella, Francesco; Spagnolo, Paolo; Ryerson, C.J.

Year: 2023

Venue: Drugs

DOI: https://doi.org/10.1007/s40265-023-01950-0

Paper Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics.

Homolak, Jan · 2023 · Advances in protein chemistry and structural biology · DOI

Full title: Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics.

Authors: Homolak, Jan

Year: 2023

Venue: Advances in protein chemistry and structural biology

DOI: https://doi.org/10.1016/bs.apcsb.2023.02.018

Paper Cellular Senescence in Idiopathic Pulmonary Fibrosis

D. Kellogg; D. Kellogg; N. Musi et al. · 2021 · Current Molecular Biology Reports · DOI

Full title: Cellular Senescence in Idiopathic Pulmonary Fibrosis

Authors: D. Kellogg; D. Kellogg; N. Musi; A. Nambiar

Year: 2021

Venue: Current Molecular Biology Reports

DOI: https://doi.org/10.1007/s40610-021-00145-4

Paper Mitochondria-associated cellular senescence mechanisms: Biochemical and pharmacological perspectives.

Atayik, Mehmet Can; Çakatay, Ufuk · 2023 · Advances in protein chemistry and structural biology · DOI

Full title: Mitochondria-associated cellular senescence mechanisms: Biochemical and pharmacological perspectives.

Authors: Atayik, Mehmet Can; Çakatay, Ufuk

Year: 2023

Venue: Advances in protein chemistry and structural biology

DOI: https://doi.org/10.1016/bs.apcsb.2023.03.003

Paper Pharmacological frontiers in senescence: Transforming senescence with drug repurposing.

Shahzadi, Andleeb; Ozyazgan, Sibel; Çakatay, Ufuk · 2025 · Advances in pharmacology (San Diego, Calif.) · DOI

Full title: Pharmacological frontiers in senescence: Transforming senescence with drug repurposing.

Authors: Shahzadi, Andleeb; Ozyazgan, Sibel; Çakatay, Ufuk

Year: 2025

Venue: Advances in pharmacology (San Diego, Calif.)

DOI: https://doi.org/10.1016/bs.apha.2025.02.010

Paper Targeting treatment resistance in cervical cancer: A new avenue for senolytic therapies.

Meyer, Madré; Fourie, Carla; van der Merwe, Haynes et al. · 2025 · Advances in medical sciences · DOI

Full title: Targeting treatment resistance in cervical cancer: A new avenue for senolytic therapies.

Authors: Meyer, Madré; Fourie, Carla; van der Merwe, Haynes; Botha, Hennie; Engelbrecht, Anna-Mart

Year: 2025

Venue: Advances in medical sciences

DOI: https://doi.org/10.1016/j.advms.2024.11.001

Paper mTOR as a senescence manipulation target: A forked road.

Saoudaoui, Sarah; Bernard, Monique; Cardin, Guillaume B et al. · 2021 · Advances in cancer research · DOI

Full title: mTOR as a senescence manipulation target: A forked road.

Authors: Saoudaoui, Sarah; Bernard, Monique; Cardin, Guillaume B; Malaquin, Nicolas; Christopoulos, Apostolos; Rodier, Francis

Year: 2021

Venue: Advances in cancer research

DOI: https://doi.org/10.1016/bs.acr.2021.02.002

Paper Cellular senescence in aging: Molecular basis, implications and therapeutic interventions.

Princilly, Jemima; Veerabhadrappa, Bhavana; Rao, Nagashree N et al. · 2023 · Advances in protein chemistry and structural biology · DOI

Full title: Cellular senescence in aging: Molecular basis, implications and therapeutic interventions.

Authors: Princilly, Jemima; Veerabhadrappa, Bhavana; Rao, Nagashree N; Dyavaiah, Madhu

Year: 2023

Venue: Advances in protein chemistry and structural biology

DOI: https://doi.org/10.1016/bs.apcsb.2023.02.021

Paper Extracellular vesicles from mesenchymal stromal cells: Therapeutic perspectives for targeting senescence in osteoarthritis

Boulestreau, Jérémy; Maumus, Marie; Jørgensen, Christian et al. · 2021 · Advanced Drug Delivery Reviews · DOI

Full title: Extracellular vesicles from mesenchymal stromal cells: Therapeutic perspectives for targeting senescence in osteoarthritis

Authors: Boulestreau, Jérémy; Maumus, Marie; Jørgensen, Christian; Noël, Danièle

Year: 2021

Venue: Advanced Drug Delivery Reviews

DOI: https://doi.org/10.1016/j.addr.2021.113836

Paper Molecular imaging for senescent cells-targeted therapeutics in aging and age-related diseases.

Cen, Peili · 2025 · Advances in pharmacology (San Diego, Calif.) · DOI

Full title: Molecular imaging for senescent cells-targeted therapeutics in aging and age-related diseases.

Authors: Cen, Peili

Year: 2025

Venue: Advances in pharmacology (San Diego, Calif.)

DOI: https://doi.org/10.1016/bs.apha.2025.01.020

Paper Cell Survival, Death, and Proliferation in Senescent and Cancer Cells: the Role of (Poly)phenols.

Sorrenti, Vincenzo; Buriani, Alessandro; Fortinguerra, Stefano et al. · 2023 · Advances in nutrition (Bethesda, Md.) · DOI

Full title: Cell Survival, Death, and Proliferation in Senescent and Cancer Cells: the Role of (Poly)phenols.

Authors: Sorrenti, Vincenzo; Buriani, Alessandro; Fortinguerra, Stefano; Davinelli, Sergio; Scapagnini, Giovanni; Cassidy, Aedin; De Vivo, Immaculata

Year: 2023

Venue: Advances in nutrition (Bethesda, Md.)

DOI: https://doi.org/10.1016/j.advnut.2023.05.014

Paper Targeting normal and cancer senescent cells as a strategy of senotherapy.

Sikora, Ewa; Bielak-Zmijewska, Anna; Mosieniak, Grazyna · 2019 · Ageing research reviews · DOI

Full title: Targeting normal and cancer senescent cells as a strategy of senotherapy.

Authors: Sikora, Ewa; Bielak-Zmijewska, Anna; Mosieniak, Grazyna

Year: 2019

Venue: Ageing research reviews

DOI: https://doi.org/10.1016/j.arr.2019.100941

Paper Senotherapeutic approach to age-related endocrine diseases.

Turgut, Şeydanur; Andican, Gülnur · 2025 · Advances in pharmacology (San Diego, Calif.) · DOI

Full title: Senotherapeutic approach to age-related endocrine diseases.

Authors: Turgut, Şeydanur; Andican, Gülnur

Year: 2025

Venue: Advances in pharmacology (San Diego, Calif.)

DOI: https://doi.org/10.1016/bs.apha.2025.02.009

Paper Molecular pathology endpoints useful for aging studies.

Niedernhofer, L J; Kirkland, J L; Ladiges, W · 2017 · Ageing research reviews · DOI

Full title: Molecular pathology endpoints useful for aging studies.

Authors: Niedernhofer, L J; Kirkland, J L; Ladiges, W

Year: 2017

Venue: Ageing research reviews

DOI: https://doi.org/10.1016/j.arr.2016.09.012

Paper Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implications.

Xie, Jinwei; Wang, Yan; Lu, Lingyun et al. · 2021 · Ageing research reviews · DOI

Full title: Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implications.

Authors: Xie, Jinwei; Wang, Yan; Lu, Lingyun; Liu, Lu; Yu, Xijie; Pei, Fuxing

Year: 2021

Venue: Ageing research reviews

DOI: https://doi.org/10.1016/j.arr.2021.101413

Paper Cellular senescence and senotherapeutics in cardiovascular diseases.

Pal, Arttatrana · 2025 · Advances in pharmacology (San Diego, Calif.) · DOI

Full title: Cellular senescence and senotherapeutics in cardiovascular diseases.

Authors: Pal, Arttatrana

Year: 2025

Venue: Advances in pharmacology (San Diego, Calif.)

DOI: https://doi.org/10.1016/bs.apha.2025.01.019

Paper Biomaterials targeting senescent cells for bone regeneration: State-of-the-art and future perspectives.

Wu, Haitong; Zhang, Qing; Zhu, Jinhao et al. · 2025 · Bioactive materials · DOI

Full title: Biomaterials targeting senescent cells for bone regeneration: State-of-the-art and future perspectives.

Authors: Wu, Haitong; Zhang, Qing; Zhu, Jinhao; Wu, Lihong; Xiao, Yin; Yang, Xuechao

Year: 2025

Venue: Bioactive materials

DOI: https://doi.org/10.1016/j.bioactmat.2025.09.002

Paper Potential connections between senescence and chemobrain: An early overview of literature.

Melhem, Nebras; Qutifan, Shahd; Alsalem, Mohammad et al. · 2025 · Ageing research reviews · DOI

Full title: Potential connections between senescence and chemobrain: An early overview of literature.

Authors: Melhem, Nebras; Qutifan, Shahd; Alsalem, Mohammad; Saleh, Tareq

Year: 2025

Venue: Ageing research reviews

DOI: https://doi.org/10.1016/j.arr.2025.102896

Paper Combined use of dasatinib and quercetin alleviates overtraining-induced deficits in learning and memory through eliminating senescent cells and reducing apoptotic cells in rat hippocampus.

Wang, Chenkang; Kang, Yu; Liu, Panwen et al. · 2023 · Behavioural brain research · DOI

Full title: Combined use of dasatinib and quercetin alleviates overtraining-induced deficits in learning and memory through eliminating senescent cells and reducing apoptotic cells in rat hippocampus.

Authors: Wang, Chenkang; Kang, Yu; Liu, Panwen; Liu, Weiwei; Chen, Wenhui; Hayashi, Toshihiko; Mizuno, Kazunori; Hattori, Shunji; Fujisaki, Hitomi; Ikejima, Takashi

Year: 2023

Venue: Behavioural brain research

DOI: https://doi.org/10.1016/j.bbr.2022.114260

Paper Unraveling the meta-hallmarks between senescent and tumor cells: A new perspective for senolytic drug discovery.

Liu, Wei; Fan, Bo; Fang, Te et al. · 2025 · Acta pharmaceutica Sinica. B · DOI

Full title: Unraveling the meta-hallmarks between senescent and tumor cells: A new perspective for senolytic drug discovery.

Authors: Liu, Wei; Fan, Bo; Fang, Te; Li, Hongyao; Zhang, Jin; Liu, Bo; Liu, Zhiyu

Year: 2025

Venue: Acta pharmaceutica Sinica. B

DOI: https://doi.org/10.1016/j.apsb.2025.08.010

Paper Therapeutic potential of senolytic agent quercetin in osteoarthritis: A systematic review and meta-analysis of preclinical studies

K. Yamaura; A. Nelson; H. Nishimura et al. · 2023 · Ageing Research Reviews · DOI

Full title: Therapeutic potential of senolytic agent quercetin in osteoarthritis: A systematic review and meta-analysis of preclinical studies

Authors: K. Yamaura; A. Nelson; H. Nishimura; Joan C. Rutledge; S. Ravuri; Chelsea S. Bahney; M. Philippon; J. Huard

Year: 2023

Venue: Ageing Research Reviews

DOI: https://doi.org/10.1016/j.arr.2023.101989

Paper Proteolysis-targeting chimera (PROTAC): A promising senolytic strategy.

Fan, Gang; Zhang, Qingping; Guo, Weiming et al. · 2026 · Ageing research reviews · DOI

Full title: Proteolysis-targeting chimera (PROTAC): A promising senolytic strategy.

Authors: Fan, Gang; Zhang, Qingping; Guo, Weiming; Liu, Miao; Tan, Dong; Tang, Zhihan; Yang, Jing

Year: 2026

Venue: Ageing research reviews

DOI: https://doi.org/10.1016/j.arr.2026.103027

Paper First evidence that senolytics are effective at decreasing senescent cells in humans

Ellison, Georgina M. · 2020 · EBioMedicine · DOI

Full title: First evidence that senolytics are effective at decreasing senescent cells in humans

Authors: Ellison, Georgina M.

Year: 2020

Venue: EBioMedicine

DOI: https://doi.org/10.1016/j.ebiom.2019.09.053

Paper Harnessing Anthocyanins to Mitigate Inflammation, Dysbiosis, and Aging in the Gastrointestinal Tract.

Livia Resende Lopes; Adriel Aparecido de Souza; Tanila Wood dos Santos et al. · 2026 · ACS Pharmacology & Translational Science · DOI

Full title: Harnessing Anthocyanins to Mitigate Inflammation, Dysbiosis, and Aging in the Gastrointestinal Tract.

Authors: Livia Resende Lopes; Adriel Aparecido de Souza; Tanila Wood dos Santos; Raquel de Cássia dos Santos

Year: 2026

Venue: ACS Pharmacology & Translational Science

DOI: https://doi.org/10.1021/acsptsci.5c00566

Paper Senolytic-Mediated Elimination of Head and Neck Tumor Cells Induced Into Senescence by Cisplatin

Ahmadinejad, Fereshteh; Bos, Tasia; Hu, Bin et al. · 2021 · Molecular Pharmacology · DOI

Full title: Senolytic-Mediated Elimination of Head and Neck Tumor Cells Induced Into Senescence by Cisplatin

Authors: Ahmadinejad, Fereshteh; Bos, Tasia; Hu, Bin; Britt, Erin; Koblinski, Jennifer E.; Souers, Andrew J.; Johansson, Joel; Faber, Anthony C.; Gewirtz, David A.; Harada, Hisashi

Year: 2021

Venue: Molecular Pharmacology

DOI: https://doi.org/10.1124/molpharm.121.000354

Paper Senolytic Combination of Dasatinib and Quercetin Promotes Tendon-to-Bone Healing by Mitigating Age-Related Senescence in Rats

Zhuochang Cai; Haoyuan Wang; Jiacheng Hu et al. · 2025 · American Journal of Sports Medicine · DOI

Full title: Senolytic Combination of Dasatinib and Quercetin Promotes Tendon-to-Bone Healing by Mitigating Age-Related Senescence in Rats

Authors: Zhuochang Cai; Haoyuan Wang; Jiacheng Hu; Cheng Qu; Shuai Chen; Xudong Liu; Cunyi Fan

Year: 2025

Venue: American Journal of Sports Medicine

DOI: https://doi.org/10.1177/03635465251381763

Thesis Role of lncRNAs in Cellular Aging

Degirmenci, Ufuk; Lei, Sun · 2017 · Nanyang Technological University (NTU) · DOI

Full title: Role of lncRNAs in Cellular Aging

Authors: Degirmenci, Ufuk; Lei, Sun

Year: 2017

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/83179

Thesis A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells

Phadwal, Kanchan; Alegre-Abarrategui, Javier; Watson, Alexander Scarth et al. · 2018 · Imperial College London · DOI

Full title: A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells

Authors: Phadwal, Kanchan; Alegre-Abarrategui, Javier; Watson, Alexander Scarth; Pike, Luke; Anbalagan, Selvakumar; Hammond, Ester M; Wade-Martins, Richard; McMichael, Andrew; Klenerman, Paul; Simon, Anna Katharina

Year: 2018

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305403400012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Senescent cells: a new Achilles' heel to exploit for cancer medicine?

Zhang, Boyi; Lam, Eric; Sun, Yu · 2019 · Imperial College London · DOI

Full title: Senescent cells: a new Achilles' heel to exploit for cancer medicine?

Authors: Zhang, Boyi; Lam, Eric; Sun, Yu

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/65560

Thesis Senescence and aging – causes, consequences, and therapeutic avenues

McHugh, D; Gil, J · 2017 · Imperial College London · DOI

Full title: Senescence and aging – causes, consequences, and therapeutic avenues

Authors: McHugh, D; Gil, J

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/52021

Thesis The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

Zhang, B; Fu, D; Xu, Q et al. · 2018 · Imperial College London · DOI

Full title: The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

Authors: Zhang, B; Fu, D; Xu, Q; Cong, X; Wu, C; Zhong, X; Ma, Y; Lv, Z; Chen, F; Han, L; Qian, M; Chin, YE; Lam, EW; Chiao, P; Sun, Y

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/58663

Thesis Mechanisms and functions of cellular senescence

Herranz, Nicolas; Gil, J · 2018 · Imperial College London · DOI

Full title: Mechanisms and functions of cellular senescence

Authors: Herranz, Nicolas; Gil, J

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/58258

Thesis Length doesn’t matter. Telomere damage triggers cellular senescence in the ageing heart

Brand, Thomas · 2019 · Imperial College London · DOI

Full title: Length doesn’t matter. Telomere damage triggers cellular senescence in the ageing heart

Authors: Brand, Thomas

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/67211

Thesis A genetic screen identifies novel regulators of the senescence-associated secretory phenotype

Georgilis, Athena Eugenia · 2019 · Imperial College London · DOI

Full title: A genetic screen identifies novel regulators of the senescence-associated secretory phenotype

Authors: Georgilis, Athena Eugenia

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/67826

Thesis Cellular senescence as a mechanism and target in chronic lung diseases

Barnes, Peter J; Baker, Jonathan; Donnelly, Louise E · 2019 · Imperial College London · DOI

Full title: Cellular senescence as a mechanism and target in chronic lung diseases

Authors: Barnes, Peter J; Baker, Jonathan; Donnelly, Louise E

Year: 2019

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/30860857

Thesis Cellular senescence: defining a path forward

Gorgoulis, Vassilis; Adams, Peter D; Alimonti, Andrea et al. · 2019 · Imperial College London · DOI

Full title: Cellular senescence: defining a path forward

Authors: Gorgoulis, Vassilis; Adams, Peter D; Alimonti, Andrea; Bennett, Dorothy C; Bischof, Oliver; Bishop, Cleo; Campisi, Judith; Collado, Manuel; Evangelou, Konstantinos; Ferbeyre, Gerardo; Gil, Jesús; Hara, Eiji; Krizhanovsky, Valery; Jurk, Diana; Maier, Andrea B; Narita, Masashi; Niedernhofer, Laura; Passos, João F; Robbins, Paul D; Schmitt, Clemens A; Sedivy, John; Vougas, Konstantinos; von Zglinicki, Thomas; Zhou, Daohong; Serrano, Manuel; Demaria, Marco

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/74383

Thesis Cardiac glycosides are broad-spectrum senolytics

Guerrero, Ana; Herranz, Nicolás; Sun, Bin et al. · 2019 · Imperial College London · DOI

Full title: Cardiac glycosides are broad-spectrum senolytics

Year: 2019

Venue: Imperial College London

DOI: https://www.nature.com/articles/s42255-019-0122-z

Thesis Blunting senescence boosts liver regeneration

Birch, Jodie; Gil, Jesus · 2020 · Imperial College London · DOI

Full title: Blunting senescence boosts liver regeneration

Authors: Birch, Jodie; Gil, Jesus

Year: 2020

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/77892

Thesis Pharmacokinetics of stilbene analogues and their application as novel anti-inflammatory agents for chronic obstructive pulmonary disease

Yeo, Samuel Chao Ming · 2019 · Imperial College London · DOI

Full title: Pharmacokinetics of stilbene analogues and their application as novel anti-inflammatory agents for chronic obstructive pulmonary disease

Authors: Yeo, Samuel Chao Ming

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/69790

Thesis Senescent stromal cells promote cancer resistance through SIRT1 loss-potentiated overproduction of small extracellular vesicles

Han, Liu; Long, Qilai; Li, Shenjun et al. · 2020 · Imperial College London · DOI

Full title: Senescent stromal cells promote cancer resistance through SIRT1 loss-potentiated overproduction of small extracellular vesicles

Authors: Han, Liu; Long, Qilai; Li, Shenjun; Xu, Qixia; Zhang, Boyi; Dou, Xuefeng; Qian, Min; Jiramongkol, Yannasittha; Guo, Jianming; Cao, Liu; Chin, Y Eugene; Lam, Eric W-F; Jiang, Jing; Sun, Yu

Year: 2020

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/79434

Thesis T cells engineered to target senescence

Wagner, Verena; Gil, Jesus · 2020 · Imperial College London · DOI

Full title: T cells engineered to target senescence

Authors: Wagner, Verena; Gil, Jesus

Year: 2020

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/80980

Thesis Galactose-modified duocarmycin prodrugs as senolytics

Guerrero, Ana; Guiho, Romain; Herranz, Nicolás et al. · 2020 · Imperial College London · DOI

Full title: Galactose-modified duocarmycin prodrugs as senolytics

Authors: Guerrero, Ana; Guiho, Romain; Herranz, Nicolás; Uren, Anthony; Withers, Dominic J; Martínez-Barbera, Juan Pedro; Tietze, Lutz F; Gil, Jesús

Year: 2020

Venue: Imperial College London

DOI: https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13133

Thesis Aged-senescent cells contribute to impaired heart regeneration

Lewis-McDougall, Fiona C; Ruchaya, Prashant J; Domenjo-Vila, Eva et al. · 2020 · Imperial College London · DOI

Full title: Aged-senescent cells contribute to impaired heart regeneration

Authors: Lewis-McDougall, Fiona C; Ruchaya, Prashant J; Domenjo-Vila, Eva; Teoh, Tze Shin; Prata, Larissa; Cottle, Beverley J; Clark, James E; Punjabi, Prakash P; Awad, Wael; Torella, Daniele; Tchkonia, Tamara; Kirkland, James L; Ellison-Hughes, Georgina M

Year: 2020

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000467861100010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Similarities and interplay between senescent cells and macrophages

Behmoaras, Jacques; Gil, Jesus · 2021 · Imperial College London · DOI

Full title: Similarities and interplay between senescent cells and macrophages

Authors: Behmoaras, Jacques; Gil, Jesus

Year: 2021

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/86495

Thesis Senescent cells: emerging targets for human aging and age-related diseases

Song, S; Lam, Eric; Tchkonia, T et al. · 2020 · Imperial College London · DOI

Full title: Senescent cells: emerging targets for human aging and age-related diseases

Authors: Song, S; Lam, Eric; Tchkonia, T; Kirkland, JL; Sun, Y

Year: 2020

Venue: Imperial College London

DOI: https://www.sciencedirect.com/science/article/pii/S0968000420300852?via%3Dihub

Thesis Senescence as a therapeutically relevant response to CDK4/6 inhibitors

Gil, Jesus · 2020 · Imperial College London · DOI

Full title: Senescence as a therapeutically relevant response to CDK4/6 inhibitors

Authors: Gil, Jesus

Year: 2020

Venue: Imperial College London

DOI: https://www.nature.com/articles/s41388-020-1354-9

Thesis Regulation of cellular senescence in COPD small airway fibroblasts

Wrench, Catherine Louise · 2022 · Imperial College London · DOI

Full title: Regulation of cellular senescence in COPD small airway fibroblasts

Authors: Wrench, Catherine Louise

Year: 2022

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/96451

Thesis Senescence and the SASP: many therapeutic avenues

Birch, J; Gil, Jesus · 2020 · Imperial College London · DOI

Full title: Senescence and the SASP: many therapeutic avenues

Authors: Birch, J; Gil, Jesus

Year: 2020

Venue: Imperial College London

DOI: http://genesdev.cshlp.org/content/34/23-24/1565

Thesis ARDD 2020: from aging mechanisms to interventions

Mkrtchyan, Garik V; Abdelmohsen, Kotb; Andreux, Penelope et al. · 2021 · Imperial College London · DOI

Full title: ARDD 2020: from aging mechanisms to interventions

Authors: Mkrtchyan, Garik V; Abdelmohsen, Kotb; Andreux, Penelope; Bagdonaite, Ieva; Barzilai, Nir; Brunak, Soren; Cabreiro, Filipe; de Cabo, Rafael; Campisi, Judith; Cuervo, Ana Maria; Demaria, Marco; Ewald, Collin Y; Fang, Evandro Fei; Faragher, Richard; Ferrucci, Luigi; Freund, Adam; Silva-Garcia, Carlos G; Georgievskaya, Anastasia; Gladyshev, Vadim N; Glass, David J; Gorbunova, Vera; de Grey, Aubrey; He, Wei-Wu; Hoeijmakers, Jan; Hoffmann, Eva; Horvath, Steve; Houtkooper, Riekelt H; Jensen, Majken K; Jensen, Martin Borch; Kane, Alice; Kassem, Moustapha; de Keizer, Peter; Kennedy, Brian; Karsenty, Gerard; Lamming, Dudley W; Lee, Kai-Fu; MacAulay, Nanna; Mamoshina, Polina; Mellon, Jim; Molenaars, Marte; Moskalev, Alexey; Mund, Andreas; Niedernhofer, Laura; Osborne, Brenna; Pak, Heidi H; Parkhitko, Andrey; Raimundo, Nuno; Rando, Thomas A; Rasmussen, Lene Juel; Reis, Carolina; Riedel, Christian G; Franco-Romero, Anais; Schumacher, Bjoern; Sinclair, David A; Suh, Yousin; Taub, Pam R; Toiber, Debra; Treebak, Jonas T; Valenzano, Dario Riccardo; Verdin, Eric; Vijg, Jan; Young, Sergey; Zhang, Lei; Bakula, Daniela; Zhavoronkov, Alex; Scheibye-Knudsen, Morten

Year: 2021

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000605608700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Aging, cellular Senescence, and progressive multiple sclerosis

Papadopoulos, Dimitrios; Magliozzi, Roberta; Mitsikostas, Dimos D et al. · 2020 · Imperial College London · DOI

Full title: Aging, cellular Senescence, and progressive multiple sclerosis

Authors: Papadopoulos, Dimitrios; Magliozzi, Roberta; Mitsikostas, Dimos D; Gorgoulis, Vassilis G; Nicholas, Richard S

Year: 2020

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/32694983

Thesis Moderate exercise inhibits age-related inflammation, liver steatosis, senescence, and tumorigenesis.

Bianchi, Arianna; Marchetti, Letizia; Hall, Zoe et al. · 2021 · Imperial College London · DOI

Full title: Moderate exercise inhibits age-related inflammation, liver steatosis, senescence, and tumorigenesis.

Authors: Bianchi, Arianna; Marchetti, Letizia; Hall, Zoe; Lemos, Henrique; Vacca, Michele; Paish, Hannah; Green, Kile; Elliott, Bronte; Tiniakos, Dina; Passos, João F; Jurk, Diana; Mann, Derek A; Wilson, Caroline L

Year: 2021

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/33441438

Thesis Sestrins induce natural killer function in senescent-like CD8(+) T cells

Pereira, Branca; De Maeyer, Roel PH; Covre, Luciana P et al. · 2020 · Imperial College London · DOI

Full title: Sestrins induce natural killer function in senescent-like CD8(+) T cells

Authors: Pereira, Branca; De Maeyer, Roel PH; Covre, Luciana P; Nehar-Belaid, Djamel; Lanna, Alessio; Ward, Sophie; Marches, Radu; Chambers, Emma S; Gomes, Daniel CO; Riddell, Natalie E; Maini, Mala K; Teixeira, Vitor H; Janes, Samuel M; Gilroy, Derek W; Larbi, Anis; Mabbott, Neil A; Ucar, Duygu; Kuchel, George A; Henson, Sian M; Strid, Jessica; Lee, Jun H; Banchereau, Jacques; Akbar, Arne N

Year: 2020

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000522383000002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging

Chen, Junyu; Sivan, Unnikrishnan; Tan, Sin Lih et al. · 2021 · Imperial College London · DOI

Full title: High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging

Authors: Chen, Junyu; Sivan, Unnikrishnan; Tan, Sin Lih; Lippo, Luciana; De Angelis, Jessica; Labella, Rossella; Singh, Amit; Chatzis, Alexandros; Cheuk, Stanley; Medhghalchi, Mino; Gil, Jesus; Hollander, Georg; Marsden, Brian D; Williams, Richard; Ramasamy, Saravana K; Kusumbe, Anjali P

Year: 2021

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/33536212

Thesis Is exercise a senolytic medicine? A systematic review

Chen, Xiang-Ke; Yi, Zhen-Ni; Wong, Gordon Tin-Chun et al. · 2021 · Imperial College London · DOI

Full title: Is exercise a senolytic medicine? A systematic review

Authors: Chen, Xiang-Ke; Yi, Zhen-Ni; Wong, Gordon Tin-Chun; Hasan, Kazi Md Mahmudul; Kwan, Joseph Shiu-Kwong; Ma, Alvin Chun-Hang; Chang, Raymond Chuen-Chung

Year: 2021

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000603448300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Therapy-induced senescence: opportunities to improve anti-cancer therapy

Prasanna, Pataje G; Citrin, Deborah E; Hildesheim, Jeffrey et al. · 2021 · Imperial College London · DOI

Full title: Therapy-induced senescence: opportunities to improve anti-cancer therapy

Authors: Prasanna, Pataje G; Citrin, Deborah E; Hildesheim, Jeffrey; Ahmed, Mansoor M; Venkatachalam, Sundar; Riscuta, Gabriela; Xi, Dan; Zheng, Guangrong; van Deursen, Jan; Goronzy, Jorg; Kron, Stephen J; Anscher, Mitchell S; Sharpless, Norman E; Campisi, Judith; Brown, Stephen L; Niedernhofer, Laura J; O'Loghlen, Ana; Georgakilas, Alexandros G; Paris, Francois; Gius, David; Gewirtz, David A; Schmitt, Clemens A; Abazeed, Mohamed E; Kirkland, James L; Richmond, Ann; Romesser, Paul B; Lowe, Scott W; Gil, Jesus; Mendonca, Marc S; Burma, Sandeep; Zhou, Daohong; Coleman, C Norman

Year: 2021

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/33792717

Thesis Targeting senescence as an anti-cancer therapy

Bousset, Laura; Gil, Jesús · 2022 · Imperial College London · DOI

Full title: Targeting senescence as an anti-cancer therapy

Authors: Bousset, Laura; Gil, Jesús

Year: 2022

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/36065138

Thesis Chronological Age Affects MSC Senescence In Vitro-A Systematic Review.

Kapetanos, Konstantinos; Asimakopoulos, Dimitrios; Christodoulou, Neophytos et al. · 2021 · University of Cambridge · DOI

Full title: Chronological Age Affects MSC Senescence In Vitro-A Systematic Review.

Authors: Kapetanos, Konstantinos; Asimakopoulos, Dimitrios; Christodoulou, Neophytos; Vogt, Antonia; Khan, Wasim

Year: 2021

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/327744

Thesis Cellular Senescence: Defining a Path Forward.

Gorgoulis, Vassilis; Adams, Peter D; Alimonti, Andrea et al. · 2019 · University of Cambridge · DOI

Full title: Cellular Senescence: Defining a Path Forward.

Year: 2019

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/299236

Thesis ARDD 2020: from aging mechanisms to interventions

Mkrtchyan, Garik V.; Abdelmohsen, Kotb; Andreux, Penelope et al. · 2020 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: ARDD 2020: from aging mechanisms to interventions

Authors: Mkrtchyan, Garik V.; Abdelmohsen, Kotb; Andreux, Penelope; Bagdonaite, Ieva; Barzilai, Nir; Brunak, Søren; Cabreiro, Filipe; de Cabo, Rafael; Campisi, Judith; Cuervo, Ana Maria; Demaria, Marco; Ewald, Collin; id_orcid0000-0003-1166-4171; Fang, Evandro Fei; Faragher, Richard; Ferrucci, Luigi; Freund, Adam; Silva-Garcia, Carlos G.; Georgievskaya, Anastasia; Gladyshev, Vadim N.; Glass, David J.; Gorbunova, Vera A.; de Grey, Aubrey; He, Weiwu; Hoeijmakers, Jan H.; Hoffmann, Eva R.; Horvath, Steve M.; Houtkooper, Riekelt H.; Jensen, Majken K.; Jensen, Martin B.; Kane, Alice E.; Kassem, Moustapha; de Keizer, Peter; Kennedy, Brian K.; Karsenty, Gerard; Lamming, Dudley W.; Lee, Kai Fu; MacAulay, Nanna; Mamoshina, Polina; Mellon, Jim; Molenaars, Marte; Moskalev, Alexey; Mund, Andreas; Niedernhofer, Laura J.; Osborne, Brenna; Pak, Heidi H.; Parkhitko, Andrey A.; Raimundo, Nuno; Rando, Thomas A.; Juel Rasmussen, Lene; Reis, Carolina; Riedel, Christian G.; Franco-Romero, Anais; Schumacher, Björn; Sinclair, David A.; Suh, Yousin; Taub, Pam R.; Toiber, Debra; Treebak, Jonas T.; Valenzano, Dario R.; Verdin, Eric; Vijg, Jan; Young, Sergey; Zhang, Lei; Bakula, Daniela; Zhavoronkov, Alex; Scheibye-Knudsen, Morten

Year: 2020

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/466960

Thesis Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control

Cavinato, Maria; Madreiter-Sokolowski, Corina T.; Büttner, Sabrina et al. · 2021 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control

Authors: Cavinato, Maria; Madreiter-Sokolowski, Corina T.; Büttner, Sabrina; Schosserer, Markus; Zwerschke, Werner; Wedel, Sophia; Grillari, Johannes; Graier, Wolfgang F.; Jansen-Dürr, Pidder

Year: 2021

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/458310

Thesis Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan

Sharma, Arastu; Chabloz, Sophie; Lapides, Rebecca A. et al. · 2023 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan

Authors: Sharma, Arastu; Chabloz, Sophie; Lapides, Rebecca A.; Roider, Elisabeth; Ewald, Collin; id_orcid0000-0003-1166-4171

Year: 2023

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/596679

Thesis DYRK1B inhibition exerts senolytic effects on endothelial cells and rescues endothelial dysfunctions

Pramotton, Francesca M.; Abukar, Asra; Hudson, Chantelle et al. · 2023 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: DYRK1B inhibition exerts senolytic effects on endothelial cells and rescues endothelial dysfunctions

Authors: Pramotton, Francesca M.; Abukar, Asra; Hudson, Chantelle; Dunbar, James; Potterton, Andrew; Tonnicchia, Simone; Taddei, Andrea; Mazza, Edoardo; id_orcid0000-0001-9427-4157; Giampietro, Costanza; id_orcid0000-0001-9427-4157

Year: 2023

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/617951

Thesis Analysis and pharmacological modulation of senescence in human epithelial stem cells

Barbaro, Vanessa; Orvieto, Antonio; Alvisi, Gualtiero et al. · 2022 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Analysis and pharmacological modulation of senescence in human epithelial stem cells

Authors: Barbaro, Vanessa; Orvieto, Antonio; Alvisi, Gualtiero; Bertolin, Marina; Bonelli, Filippo; Liehr, Thomas; Harutyunyan, Tigran; Kankel, Stefanie; Joksic, Gordana; Ferrari, Stefano; Daniele, Elena; Ponzin, Diego; Bettio, Daniela; Salviati, Leonardo; Di Iorio, Enzo

Year: 2022

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/554396

Thesis Youthful and age-related matreotypes predict drugs promoting longevity

Statzer, Cyril; Jongsma, Elisabeth; Liu, Sean X. et al. · 2021 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Youthful and age-related matreotypes predict drugs promoting longevity

Authors: Statzer, Cyril; Jongsma, Elisabeth; Liu, Sean X.; Dakhovnik, Alexander; Wandrey, Franziska; Mozharovskyi, Pavlo; Zülli, Fred; Ewald, Collin Y.

Year: 2021

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/528692

Thesis Sex differences in pharmacological interventions and their effects on lifespan and healthspan outcomes: a systematic review

Knufinke, Marie; MacArthur, Michael R.; Ewald, Collin et al. · 2023 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Sex differences in pharmacological interventions and their effects on lifespan and healthspan outcomes: a systematic review

Authors: Knufinke, Marie; MacArthur, Michael R.; Ewald, Collin; id_orcid0000-0003-1166-4171; Mitchell, Sarah J.

Year: 2023

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/641207

Thesis Youthful and age-related matreotypes predict drugs promoting longevity

Statzer, Cyril; Jongsma, Elisabeth; Liu, Sean X. et al. · 2021 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Youthful and age-related matreotypes predict drugs promoting longevity

Authors: Statzer, Cyril; Jongsma, Elisabeth; Liu, Sean X.; Dakhovnik, Alexander

Year: 2021

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/500377

Thesis Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer

Troiani, Martina; Colucci, Manuel; D’Ambrosio, Mariantonietta et al. · 2022 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer

Authors: Troiani, Martina; Colucci, Manuel; D’Ambrosio, Mariantonietta; Guccini, Ilaria; Pasquini, Emiliano; Varesi, Angelica; Valdata, Aurora; Mosole, Simone; Revandkar, Ajinkya; Attanasio, Giuseppe; Rinaldi, Andrea; Rinaldi, Anna; Bolis, Marco; Cippà, Pietro; Alimonti, Andrea; id_orcid0000-0002-9362-2313

Year: 2022

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/657208

Thesis Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Lyu, Yu-Xuan; Fu, Qiang; Wilczok, Dominika et al. · 2024 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Authors: Lyu, Yu-Xuan; Fu, Qiang; Wilczok, Dominika; Ying, Kejun; King, Aaron; Antebi, Adam; Vojta, Aleksandar; Stolzing, Alexandra; Moskalev, Alexey; Georgievskaya, Anastasia; Maier, Andrea B.; Olsen, Andrea; Groth, Anja; Simon, Anna Katharina; Brunet, Anne; Jamil, Aisyah; Kulaga, Anton; Bhatti, Asif; Yaden, Benjamin; Klarlund Pedersen, Bente; Ewald, Collin; id_orcid0000-0003-1166-4171; et al.

Year: 2024

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/711420

Thesis In‑vivo screening implicates endoribonuclease Regnase‑1 in modulating senescence‑associated lysosomal changes

Venz, Richard; Goyala, Anita; Soto-Gamez, Abel et al. · 2024 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: In‑vivo screening implicates endoribonuclease Regnase‑1 in modulating senescence‑associated lysosomal changes

Authors: Venz, Richard; Goyala, Anita; Soto-Gamez, Abel; Yenice, Tugce; Demaria, Marco; Ewald, Collin; id_orcid0000-0003-1166-4171

Year: 2024

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/635746

Thesis Drug Screening Implicates Chondroitin Sulfate as a Potential Longevity Pill

Ewald, Collin Y. · 2021 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Drug Screening Implicates Chondroitin Sulfate as a Potential Longevity Pill

Authors: Ewald, Collin Y.

Year: 2021

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/528982

Thesis Injectable Senolytic Hydrogel Depot for the Clearance of Senescent Cells

Garau Paganella, Lorenza; Bovone, Giovanni; id_orcid0000-0002-8508-0737 et al. · 2025 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Injectable Senolytic Hydrogel Depot for the Clearance of Senescent Cells

Authors: Garau Paganella, Lorenza; Bovone, Giovanni; id_orcid0000-0002-8508-0737; Cuni, Filippo; Labouesse, Celine; id_orcid0000-0002-8508-0737; Cui, Yifan; Giampietro, Costanza; id_orcid0000-0002-8508-0737; Tibbitt, Mark W.; id_orcid0000-0002-8508-0737

Year: 2025

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/716285

Thesis Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

Singh, Anurag; D'Amico, Davide; Andreux, Penelope A. et al. · 2022 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

Authors: Singh, Anurag; D'Amico, Davide; Andreux, Penelope A.; Fouassier, Andreane M.; Blanco-Bose, William; Evans, Mal; Aebischer, Patrick; Auwerx, Johan; Rinsch, Chris

Year: 2022

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/189985

Thesis The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

Andreux, Penelope A.; Blanco-Bose, William; Ryu, Dongryeol et al. · 2019 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

Authors: Andreux, Penelope A.; Blanco-Bose, William; Ryu, Dongryeol; Burdet, Frederic; Ibberson, Mark; Aebischer, Patrick; Auwerx, Johan; Singh, Anurag; Rinsch, Chris

Year: 2019

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/164094

Thesis Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems

Girotra, Mukul; Chiang, Yi-Hsuan; Charmoy, Melanie et al. · 2023 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems

Authors: Girotra, Mukul; Chiang, Yi-Hsuan; Charmoy, Melanie; Ginefra, Pierpaolo; Hope, Helen Carrasco; Bataclan, Charles; Yu, Yi-Ru; Schyrr, Frederica; Franco, Fabien; Geiger, Hartmut; Cherix, Stephane; Ho, Ping-Chih; Naveiras, Olaia; Auwerx, Johan; Held, Werner; Vannini, Nicola

Year: 2023

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/201487

Thesis Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors

Zhao, Yang · 2023 · Theses · DOI

Full title: Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors

Authors: Zhao, Yang

Year: 2023

Venue: Theses

DOI: https://infoscience.epfl.ch/handle/20.500.14299/200740

Thesis EXAMINING HETEROGENEITY OF CELLULAR SENESCENCE WITH MULTIPLEXING IMMUNOLABELING

Zheng, Shuyuan · 2023 · Johns Hopkins University · DOI

Full title: EXAMINING HETEROGENEITY OF CELLULAR SENESCENCE WITH MULTIPLEXING IMMUNOLABELING

Authors: Zheng, Shuyuan

Year: 2023

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/68607

Thesis Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Ryu, Dongryeol; Mouchiroud, Laurent; Andreux, Pénélope A et al. · 2016 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Authors: Ryu, Dongryeol; Mouchiroud, Laurent; Andreux, Pénélope A; Katsyuba, Elena; Moullan, Norman; Nicolet-dit-Félix, Amandine A; Williams, Evan G; Jha, Pooja; Lo Sasso, Giuseppe; Huzard, Damien; Aebischer, Patrick; Sandi, Carmen; Rinsch, Chris; Auwerx, Johan

Year: 2016

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/128047

Thesis ssDNA Nanotubes as a Targeted Drug Delivery Vehicle for Triple Negative Breast Cancer

Lin, Lucy · 2022 · Johns Hopkins University · DOI

Full title: ssDNA Nanotubes as a Targeted Drug Delivery Vehicle for Triple Negative Breast Cancer

Authors: Lin, Lucy

Year: 2022

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/67261

Thesis BIOPHYSICAL PROPERTIES ENCODE FUNCTIONAL SUBTYPES OF SINGLE CELLS in HEALTH, AGING, AND DISEASE

Kamat, Pratik S · 2025 · Johns Hopkins University · DOI

Full title: BIOPHYSICAL PROPERTIES ENCODE FUNCTIONAL SUBTYPES OF SINGLE CELLS in HEALTH, AGING, AND DISEASE

Authors: Kamat, Pratik S

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70299

Thesis Endplate Senescent Osteoclasts Induce Sensory Innervation and Spine Pain

Benkato, Kheiria Gamal · 2023 · Johns Hopkins University · DOI

Full title: Endplate Senescent Osteoclasts Induce Sensory Innervation and Spine Pain

Authors: Benkato, Kheiria Gamal

Year: 2023

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/68664

Thesis CIRCULATING BIOMARKERS OF SENESCENCE REVEAL HIGH RESOLUTION HEALTH STATUS AND TRAJECTORIES IN HUMAN LONGITUDINAL STUDIES

Olinger, Bradley Andrew · 2025 · Johns Hopkins University · DOI

Full title: CIRCULATING BIOMARKERS OF SENESCENCE REVEAL HIGH RESOLUTION HEALTH STATUS AND TRAJECTORIES IN HUMAN LONGITUDINAL STUDIES

Authors: Olinger, Bradley Andrew

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70546

Thesis Evaluating the effect of osteoarthritis on the distant tumor microenvironment and response to immunotherapy

Gray-Gaillard, Elise Francoise · 2025 · Johns Hopkins University · DOI

Full title: Evaluating the effect of osteoarthritis on the distant tumor microenvironment and response to immunotherapy

Authors: Gray-Gaillard, Elise Francoise

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70633

Thesis Oncogene-induced senescence: From biology to therapy

Zhu, H; Blake, S; Kusuma, FK et al. · 2020 · University of Melbourne · DOI

Full title: Oncogene-induced senescence: From biology to therapy

Authors: Zhu, H; Blake, S; Kusuma, FK; Pearson, RB; Kang, J; Chan, KT

Year: 2020

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/251365

Thesis Senescence in tissue samples of humans with age-related diseases: A systematic review

Tuttle, CSL; Luesken, SWM; Waaijer, MEC et al. · 2021 · University of Melbourne · DOI

Full title: Senescence in tissue samples of humans with age-related diseases: A systematic review

Authors: Tuttle, CSL; Luesken, SWM; Waaijer, MEC; Maier, AB

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/281656

Thesis Targeting aging with urolithin A in humans: A systematic review

Kuerec, AH; Lim, XK; Khoo, AL et al. · 2024 · University of Melbourne · DOI

Full title: Targeting aging with urolithin A in humans: A systematic review

Authors: Kuerec, AH; Lim, XK; Khoo, AL; Sandalova, E; Guan, L; Feng, L; Maier, AB

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/349755

Thesis BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia

Carrington, EM; Louis, C; Kratina, T et al. · 2021 · Theses · DOI

Full title: BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia

Authors: Carrington, EM; Louis, C; Kratina, T; Hancock, M; Keenan, CR; Iannarella, N; Allan, RS; Wardak, AZ; Czabotar, PE; Herold, MJ; Schenk, RL; White, CA; D'Silva, D; Yang, Y; Wong, W; Wong, H; Bryant, VL; Huntington, ND; Rautela, J; Sutherland, RM; Zhan, Y; Hansen, J; Nhu, D; Lessene, G; Wicks, IP; Lew, AM

Year: 2021

Venue: Theses

DOI: https://hdl.handle.net/11343/281460

Thesis Therapeutic effect of dietary ingredients on cellular senescence in animals and humans: A systematic review

Guan, L; Eisenmenger, A; Crasta, KC et al. · 2024 · University of Melbourne · DOI

Full title: Therapeutic effect of dietary ingredients on cellular senescence in animals and humans: A systematic review

Authors: Guan, L; Eisenmenger, A; Crasta, KC; Sandalova, E; Maier, AB

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/348486

Thesis Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

Widjaja, AA; Lim, WW; Viswanathan, S et al. · 2024 · University of Melbourne · DOI

Full title: Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

Authors: Widjaja, AA; Lim, WW; Viswanathan, S; Chothani, S; Corden, B; Dasan, CM; Goh, JWT; Lim, R; Singh, BK; Tan, J; Pua, CJ; Lim, SY; Adami, E; Schafer, S; George, BL; Sweeney, M; Xie, C; Tripathi, M; Sims, NA; Hübner, N; Petretto, E; Withers, DJ; Ho, L; Gil, J; Carling, D; Cook, SA

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/349675

Thesis Stress, cell senescence and organismal ageing

de Magalhaes, Joao Pedro; Passos, Joao F · 2018 · University of Liverpool · DOI

Full title: Stress, cell senescence and organismal ageing

Authors: de Magalhaes, Joao Pedro; Passos, Joao F

Year: 2018

Venue: University of Liverpool

DOI: oai:livrepository.liverpool.ac.uk:3008468

Thesis Human Ageing Genomic Resources: new and updated databases

Tacutu, Robi; Thornton, Daniel; Johnson, Emily et al. · 2017 · University of Liverpool · DOI

Full title: Human Ageing Genomic Resources: new and updated databases

Authors: Tacutu, Robi; Thornton, Daniel; Johnson, Emily; Budovsky, Arie; Barardo, Diogo; Craig, Thomas; Diana, Eugene; Lehmann, Gilad; Toren, Dmitri; Wang, Jingwei; Fraifeld, Vadim E; de Magalhaes, Joao P

Year: 2017

Venue: University of Liverpool

DOI: https://livrepository.liverpool.ac.uk/3012389/1/HAGR_NAR2.docx

Thesis Senescent Cells in Cancer: Wanted or Unwanted Citizens

Niklander, Sven E; Lambert, Daniel W; Hunter, Keith D · 2021 · University of Liverpool · DOI

Full title: Senescent Cells in Cancer: Wanted or Unwanted Citizens

Authors: Niklander, Sven E; Lambert, Daniel W; Hunter, Keith D

Year: 2021

Venue: University of Liverpool

DOI: oai:livrepository.liverpool.ac.uk:3155453

Thesis The Business of Anti-Aging Science

de Magalhaes, Joao Pedro; Stevens, Michael; Thornton, Daniel · 2017 · University of Liverpool · DOI

Full title: The Business of Anti-Aging Science

Authors: de Magalhaes, Joao Pedro; Stevens, Michael; Thornton, Daniel

Year: 2017

Venue: University of Liverpool

DOI: https://livrepository.liverpool.ac.uk/3008938/1/aging_business_TrendsBiotech_revised_final.docx

Thesis Intercellular communication analysis of the human retinal pigment epithelial and choroidal cells predicts pathways associated with aging, cellular senescence and age-related macular degeneration

Dhirachaikulpanich, Dhanach; Lagger, Cyril; Chatsirisupachai, Kasit et al. · 2022 · University of Liverpool · DOI

Full title: Intercellular communication analysis of the human retinal pigment epithelial and choroidal cells predicts pathways associated with aging, cellular senescence and age-related macular degeneration

Authors: Dhirachaikulpanich, Dhanach; Lagger, Cyril; Chatsirisupachai, Kasit; de Magalhaes, Joao Pedro; Paraoan, Luminita

Year: 2022

Venue: University of Liverpool

DOI: oai:livrepository.liverpool.ac.uk:3166393

Thesis Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis

Admasu, Tesfahun Dessale; Kim, Kristie; Rae, Michael et al. · 2023 · University of Liverpool · DOI

Full title: Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis

Authors: Admasu, Tesfahun Dessale; Kim, Kristie; Rae, Michael; Avelar, Roberto; Gonciarz, Ryan L; Rebbaa, Abdelhadi; Magalhaes, Joao Pedro de; Renslo, Adam R; Stolzing, Alexandra; Sharma, Amit

Year: 2023

Venue: University of Liverpool

DOI: oai:livrepository.liverpool.ac.uk:3168520

Thesis Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib plus quercetin

Raffaele, Marco; Kovacovicova, Kristina; Frohlich, Jan et al. · 2021 · University of Liverpool · DOI

Full title: Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib plus quercetin

Authors: Raffaele, Marco; Kovacovicova, Kristina; Frohlich, Jan; Lo Re, Oriana; Giallongo, Sebastiano; Oben, Jude A; Faldyna, Martin; Leva, Lenka; Giannone, Antonino Giulio; Cabibi, Daniela; Vinciguerra, Manlio

Year: 2021

Venue: University of Liverpool

DOI: oai:livrepository.liverpool.ac.uk:3167841

Thesis Potential senotherapeutic candidates and their combinations derived from transcriptional connectivity and network measures

Nayeri Rad, Amirhossein; Shams, Golnaz; Avelar, Roberto A et al. · 2022 · University of Liverpool · DOI

Full title: Potential senotherapeutic candidates and their combinations derived from transcriptional connectivity and network measures

Authors: Nayeri Rad, Amirhossein; Shams, Golnaz; Avelar, Roberto A; Morowvat, Mohammad Hossein; Ghasemi, Younes

Year: 2022

Venue: University of Liverpool

DOI: oai:livrepository.liverpool.ac.uk:3152620

Thesis The costs and benefits of senotherapeutics for human health

Raffaele, Marco; Vinciguerra, Manlio · 2022 · University of Liverpool · DOI

Full title: The costs and benefits of senotherapeutics for human health

Authors: Raffaele, Marco; Vinciguerra, Manlio

Year: 2022

Venue: University of Liverpool

DOI: oai:livrepository.liverpool.ac.uk:3167981

Thesis Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

Dörr, JR; Yu, Y; Milanovic, M et al. · 2013 · Technical University of Munich (TUM) · DOI

Full title: Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

Authors: Dörr, JR;Yu, Y;Milanovic, M;Beuster, G;Zasada, C;Däbritz, JH;Lisec, J;Lenze, D;Gerhardt, A;Schleicher, K;Kratzat, S;Purfürst, B;Walenta, S;Mueller-Klieser, W;Gräler, M;Hummel, M;Keller, U;Buck, AK;Dörken, B;Willmitzer, L;Reimann, M;Kempa, S;Lee, S;Schmitt, CA

Year: 2013

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1211227

Thesis Targeting immune dysfunction in aging

Borgoni, Simone; Kudryashova, Ksenia S; Burka, Ksenia et al. · 2021 · University of Liverpool · DOI

Full title: Targeting immune dysfunction in aging

Authors: Borgoni, Simone; Kudryashova, Ksenia S; Burka, Ksenia; de Magalhaes, Joao Pedro

Year: 2021

Venue: University of Liverpool

DOI: oai:livrepository.liverpool.ac.uk:3147023

Thesis Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.

Gabriel, Diana; Shafry, Dinah Dorith; Gordon, Leslie B et al. · 2017 · Technical University of Munich (TUM) · DOI

Full title: Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.

Authors: Gabriel, Diana;Shafry, Dinah Dorith;Gordon, Leslie B;Djabali, Karima

Year: 2017

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1448624

Thesis Role of telomere dysfunction in aging and its detection by biomarkers.

von Figura, G; Hartmann, D; Song, Z et al. · 2009 · Technical University of Munich (TUM) · DOI

Full title: Role of telomere dysfunction in aging and its detection by biomarkers.

Authors: von Figura, G;Hartmann, D;Song, Z;Rudolph, KL

Year: 2009

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/978840

Thesis Targeting proteostatic maintenance and mitochondrial function with phytochemical compounds in models of brain and skeletal muscle aging

Walsh, Maureen Ann, author; Hamilton, Karyn L., advisor; Fling, Brett W., committee member et al. · 2024 · Colorado State University · DOI

Full title: Targeting proteostatic maintenance and mitochondrial function with phytochemical compounds in models of brain and skeletal muscle aging

Authors: Walsh, Maureen Ann, author; Hamilton, Karyn L., advisor; Fling, Brett W., committee member; Moreno, Julie A., committee member; LaRocca, Thomas J., committee member; Santangelo, Kelly S., committee member

Year: 2024

Venue: Colorado State University

DOI: https://hdl.handle.net/10217/238466

Thesis Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells.

Liu, Chang; Arnold, Rouven; Henriques, Gonçalo et al. · 2019 · Technical University of Munich (TUM) · DOI

Full title: Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells.

Authors: Liu, Chang;Arnold, Rouven;Henriques, Gonçalo;Djabali, Karima

Year: 2019

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1593653

Thesis Cellular Senescence in Periodontitis: From Pathogenesis to Therapeutics

Kantapon Rattanaprukskul · 2023 · University of Pennsylvania · DOI

Full title: Cellular Senescence in Periodontitis: From Pathogenesis to Therapeutics

Authors: Kantapon Rattanaprukskul

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/59358

Thesis Using pharmacological and proteomic analysis to investigate molecular pathways in cellular senescence

Walters, H · 2019 · University of Oxford - ORA · DOI

Full title: Using pharmacological and proteomic analysis to investigate molecular pathways in cellular senescence

Authors: Walters, H

Year: 2019

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:68d459fd-1972-46ba-9c7b-ded4722e913d

Thesis Regulation and inhibition of pro-tumorigenic microenvironments

Oster Alspach, Elise · 2014 · Washington University in St. Louis · DOI

Full title: Regulation and inhibition of pro-tumorigenic microenvironments

Authors: Oster Alspach, Elise

Year: 2014

Venue: Washington University in St. Louis

DOI: https://openscholarship.wustl.edu/etd/1330

Thesis Senescent Cancer-Associated Fibroblasts Mediate Immunosuppression and Promote Breast Cancer Progression

Ye, Jiayu · 2025 · Washington University in St. Louis · DOI

Full title: Senescent Cancer-Associated Fibroblasts Mediate Immunosuppression and Promote Breast Cancer Progression

Authors: Ye, Jiayu

Year: 2025

Venue: Washington University in St. Louis

DOI: https://openscholarship.wustl.edu/art_sci_etds/3547

Thesis Overcoming immunosenescence: strategies to modulate DNA damage and senescence in immune cells and fibroblasts

Kell, L · 2024 · University of Oxford - ORA · DOI

Full title: Overcoming immunosenescence: strategies to modulate DNA damage and senescence in immune cells and fibroblasts

Authors: Kell, L

Year: 2024

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:323fcbc3-126a-43ed-8fca-67c888ce245d

Thesis Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology

Roth-Walter, Franziska (University of Veterinary Medicine, Vienna / Medical University of Vienna); Stellato, C. (University of Salerno); Kohl, E. F. (University Medical Center Utrecht) et al. · 2023 · University of Veterinary Medicine Vienna (Vetmeduni Vienna) · DOI

Authors: Roth-Walter, Franziska (University of Veterinary Medicine, Vienna / Medical University of Vienna); Stellato, C. (University of Salerno); Kohl, E. F. (University Medical Center Utrecht); Eguiluz-Gracia, I. (Instituto de Investigación Biomédica de Málaga); Diamant, Z. (Skåne University Hospital / Charles University / University of Groningen); Adcock, I. M. (Imperial College London); Benito-Villalvilla, C. (Universidad Complutense de Madrid); Bianchini, Rodolfo (University of Veterinary Medicine Vienna); Bjermer, L. (Lund University); Caramori, G. (University of Parma); Cari, L. (University of Perugia); Chung, K. F. (Imperial College London); Van Esch, B. C. A. M. (Utrecht University); Sokolowska, M. (University of Zurich / CK-CARE); Redegeld, F. (Utrecht University); Palomares, O. (Universidad Complutense de Madrid); O'Mahony, L. (University College Cork); Nocentini, G. (University of Perugia); Levi-Schaffer, F. (Hebrew University of Jerusalem); Jesenak, M. (Comenius University Bratislava)

Year: 2023

Venue: University of Veterinary Medicine Vienna (Vetmeduni Vienna)

DOI: https://phaidra.vetmeduni.ac.at/o:3333

Thesis Integrated transcriptomic and proteomic profiling of responses to clinical and novel bisphosphonates

Lu, J · 2024 · University of Oxford - ORA · DOI

Full title: Integrated transcriptomic and proteomic profiling of responses to clinical and novel bisphosphonates

Authors: Lu, J

Year: 2024

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:65aa7311-0504-4795-8571-94b4ef42de0c

Thesis A Subset of Senescent Myofibroblasts Orchestrates Immunosuppression in Pancreatic Cancer.

Belle, Jad · 2025 · Washington University in St. Louis · DOI

Full title: A Subset of Senescent Myofibroblasts Orchestrates Immunosuppression in Pancreatic Cancer.

Authors: Belle, Jad

Year: 2025

Venue: Washington University in St. Louis

DOI: https://openscholarship.wustl.edu/art_sci_etds/3466

Thesis Aging and drug discovery

Bakula, Daniela; Aliper, Alexander M.; Mamoshina, Polina et al. · 2018 · University of Copenhagen · DOI

Full title: Aging and drug discovery

Authors: Bakula, Daniela; Aliper, Alexander M.; Mamoshina, Polina; Petr, Michael A.; Teklu, Amanuel; Baur, Joseph A.; Campisi, Judith; Ewald, Collin Y.; Georgievskaya, Anastasia; Gladyshev, Vadim N.; Kovalchuk, Olga; Lamming, Dudley W.; Luijsterburg, Martijn S.; Martín-Montalvo, Alejandro; Maudsley, Stuart; Mkrtchyan, Garik V.; Moskalev, Alexey; Jay Olshansky, S.; Ozerov, Ivan V.; Pickett, Alexander; Ristow, Michael; Zhavoronkov, Alex; Scheibye-Knudsen, Morten

Year: 2018

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/482cf743-9684-469f-95cf-421b51dafa33

Thesis Characterising senescent fibroblast dynamics in human osteoarthritis: function and development

Deng, Y · 2025 · Theses · DOI

Full title: Characterising senescent fibroblast dynamics in human osteoarthritis: function and development

Authors: Deng, Y

Year: 2025

Venue: Theses

DOI: oai:ora.ox.ac.uk:uuid:addcee8a-1b29-4ab1-b727-bd362608f1ea

Thesis Epigenetic Mechanisms and Senescence in Aging and Cancer

Karpova, Alla · 2024 · Washington University in St. Louis · DOI

Full title: Epigenetic Mechanisms and Senescence in Aging and Cancer

Authors: Karpova, Alla

Year: 2024

Venue: Washington University in St. Louis

DOI: https://openscholarship.wustl.edu/art_sci_etds/3337

Thesis The role of p53 and ASPP2 in neurodegenerative disease

Turnquist, C · 2015 · University of Oxford - ORA · DOI

Full title: The role of p53 and ASPP2 in neurodegenerative disease

Authors: Turnquist, C

Year: 2015

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:e7d4cdfb-9ebe-4716-b3ca-d50b4b278d1a

Thesis Latest advances in aging research and drug discovery

Bakula, Daniela; Ablasser, Andrea; Aguzzi, Adriano et al. · 2019 · University of Copenhagen · DOI

Full title: Latest advances in aging research and drug discovery

Authors: Bakula, Daniela; Ablasser, Andrea; Aguzzi, Adriano; Antebi, Adam; Barzilai, Nir; Bittner, Martin Immanuel; Jensen, Martin Borch; Calkhoven, Cornelis F.; Chen, Danica; de Grey, Aubrey D.N.J.; Feige, Jerome N.; Georgievskaya, Anastasia; Gladyshev, Vadim N.; Golato, Tyler; Gudkov, Andrei V.; Hoppe, Thorsten; Kaeberlein, Matt; Katajisto, Pekka; Kennedy, Brian K.; Lal, Unmesh; Martin-Villalba, Ana; Moskalev, Alexey A.; Ozerov, Ivan; Petr, Michael A.; Reason; Rubinsztein, David C.; Tyshkovskiy, Alexander; Vanhaelen, Quentin; Zhavoronkov, Alex; Scheibye-Knudsen, Morten

Year: 2019

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/ba30b908-e988-4768-8b64-03619d213219

Thesis Cellular senescence and chronological age in various human tissues:A systematic review and meta-analysis

Tuttle, Camilla S. L.; Waaijer, Mariette E. C.; Slee-Valentijn, Monique S. et al. · 2020 · University of Copenhagen · DOI

Full title: Cellular senescence and chronological age in various human tissues:A systematic review and meta-analysis

Authors: Tuttle, Camilla S. L.; Waaijer, Mariette E. C.; Slee-Valentijn, Monique S.; Stijnen, Theo; Westendorp, Rudi; Maier, Andrea B.

Year: 2020

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/861db463-8758-4bd6-8a52-ad7703e0dcfe

Thesis Interventions for age-related diseases:Shifting the paradigm

Figueira, Inês; Fernandes, Adelaide; Mladenovic Djordjevic, Aleksandra et al. · 2016 · University of Copenhagen · DOI

Full title: Interventions for age-related diseases:Shifting the paradigm

Authors: Figueira, Inês; Fernandes, Adelaide; Mladenovic Djordjevic, Aleksandra; Lopez-Contreras, Andres; Henriques, Catarina M; Selman, Colin; Ferreiro, Elisabete; Gonos, Efstathios S; Trejo, José Luis; Misra, Juhi; Rasmussen, Lene Juel; Xapelli, Sara; Ellam, Timothy; Bellantuono, Ilaria

Year: 2016

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/aa40080c-5965-4caf-93fb-88e42e79ce83

Thesis Mitophagy and Neuroprotection

Lou, Guofeng; Palikaras, Konstantinos; Lautrup, Sofie et al. · 2020 · University of Copenhagen · DOI

Full title: Mitophagy and Neuroprotection

Authors: Lou, Guofeng; Palikaras, Konstantinos; Lautrup, Sofie; Scheibye-Knudsen, Morten; Tavernarakis, Nektarios; Fang, Evandro F.

Year: 2020

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/935b40f3-1bca-4510-87c3-1aa52ea78bae

Thesis Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration

Irvine, Katharine M; Skoien, Richard; Bokil, Nilesh J et al. · 2014 · Charles Sturt University - Research Output · DOI

Full title: Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration

Authors: Irvine, Katharine M; Skoien, Richard; Bokil, Nilesh J; Melino, Michelle; Thomas, Gethin P; Loo, Dorothy; Gabrielli, Brian; Hill, Michelle M; Sweet, Matthew J; Clouston, Andrew D; Powell, Elizabeth E

Year: 2014

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/ca64c012-26b4-4b60-9629-1b03425f7fef

Thesis Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway

Fang, Evandro Fei; Waltz, Tyler B; Kassahun, Henok et al. · 2017 · University of Copenhagen · DOI

Full title: Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway

Authors: Fang, Evandro Fei; Waltz, Tyler B; Kassahun, Henok; Lu, Qiping; Kerr, Jesse S; Morevati, Marya; Fivenson, Elayne M; Wollman, Bradley N; Marosi, Krisztina; Wilson, Mark A; Iser, Wendy B; Eckley, David Mark; Zhang, Yongqing; Lehrmann, Elin; Goldberg, Ilya G.; Scheibye-Knudsen, Morten; Mattson, Mark P.; Nilsen, Hilde; Bohr, Vilhelm A; Becker, Kevin G.

Year: 2017

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/f36b8c3f-6927-4986-9a19-d8d50ea75842

Thesis Efeitos da associação de quercetina e dasatinibe na expressão de citocinas pró-inflamatórias e na perda óssea associada à idade em camundongos

Battistelli, Luisa Souza [UNESP] · 2025 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Efeitos da associação de quercetina e dasatinibe na expressão de citocinas pró-inflamatórias e na perda óssea associada à idade em camundongos

Authors: Battistelli, Luisa Souza [UNESP]

Year: 2025

Venue: Universidade Estadual Paulista (UNESP)

DOI: https://hdl.handle.net/11449/259840

Thesis 3D Fibrin Microgel System for Senescense Detection

Martinez, Fernando · 2025 · Georgia Institute of Technology · DOI

Full title: 3D Fibrin Microgel System for Senescense Detection

Authors: Martinez, Fernando

Year: 2025

Venue: Georgia Institute of Technology

DOI: https://hdl.handle.net/1853/77752

Thesis Impact of Renal Senescence on Kidney Allograft Outcome

He, An · 2024 · Freie Universität Berlin (Refubium) · DOI

Full title: Impact of Renal Senescence on Kidney Allograft Outcome

Authors: He, An

Year: 2024

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/41700

Thesis Is exercise a senolytic medicine? A systematic review

Chen, Xiangke; Yi, Zhen-Ni; Wong, Gordon Tin-Chun et al. · 2021 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Is exercise a senolytic medicine? A systematic review

Authors: Chen, Xiangke; Yi, Zhen-Ni; Wong, Gordon Tin-Chun; Hasan, Kazi Md. Mahmudul; Kwan, Joseph Shiu-Kwong; Ma, Alvin Chun-Hang; Chang, Raymond Chuen-Chung

Year: 2021

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-125199

Thesis Molecular interplays in hepatic stellate cells: apoptosis, senescence, and phenotype reversion as cellular connections that modulate liver fibrosis

Silva, Brenda de Oliveira da [UNESP]; Ramos, Leticia Ferrreira [UNESP]; Moraes, Karen C. M. [UNESP] · 2018 · Theses · DOI

Full title: Molecular interplays in hepatic stellate cells: apoptosis, senescence, and phenotype reversion as cellular connections that modulate liver fibrosis

Authors: Silva, Brenda de Oliveira da [UNESP]; Ramos, Leticia Ferrreira [UNESP]; Moraes, Karen C. M. [UNESP]

Year: 2018

Venue: Theses

DOI: http://dx.doi.org/10.1002/cbin.10790

Thesis Vascular cell senescence contributes to blood-brain barrier breakdown

Yamazaki, Yu; Baker, Darren J.; Tachibana, Masaya et al. · 2016 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Vascular cell senescence contributes to blood-brain barrier breakdown

Authors: Yamazaki, Yu; Baker, Darren J.; Tachibana, Masaya; Liu, Chia-Chen; Van Deursen, Jan M.; Brott, Thomas G.; Bu, Guojun; Kanekiyo, Takahisa

Year: 2016

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-130551

Thesis Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence

Fletcher-Sananikone, Eliot; Kanji, Suman; Tomimatsu, Nozomi et al. · 2022 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence

Authors: Fletcher-Sananikone, Eliot; Kanji, Suman; Tomimatsu, Nozomi; Cristofaro, Luis Fernando MacEdo Di [UNESP]; Kollipara, Rahul K.; Saha, Debabrata; Floyd, John R.; Sung, Patrick; Hromas, Robert; Burns, Terry C.; Kittler, Ralf; Habib, Amyn A.; Mukherjee, Bipasha; Burma, Sandeep

Year: 2022

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1158/0008-5472.CAN-21-0752

Thesis Microglial repopulation restricts ocular inflammation and choroidal neovascularization in mice

Song, Yinting; Liao, Yuefeng; Liu, Tong et al. · 2024 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Microglial repopulation restricts ocular inflammation and choroidal neovascularization in mice

Authors: Song, Yinting; Liao, Yuefeng; Liu, Tong; Chen, Yanxian; Wang, Fei; Zhou, Zixiang; Zhang, Weili; Li, Jinying

Year: 2024

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-138773

Thesis Nanosize Non-Viral Gene Therapy Reverses Senescence Reprograming Driven by PBRM1 Deficiency to Suppress iCCA Progression

Wu, Xiwen; Zhang, Yi; Ding, Yuan et al. · 2025 · Theses · DOI

Full title: Nanosize Non-Viral Gene Therapy Reverses Senescence Reprograming Driven by PBRM1 Deficiency to Suppress iCCA Progression

Authors: Wu, Xiwen; Zhang, Yi; Ding, Yuan; Yang, Jiali; Song, Zimin; Lin, Shuirong; Zhang, Ruhe; Wu, Jun; Shen, Shunli

Year: 2025

Venue: Theses

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-146537

Thesis Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: Implications for its hepatotoxicity

Zhang, Yi; Zhou, Zhiwei; Jin, Hua et al. · 2015 · Theses · DOI

Full title: Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: Implications for its hepatotoxicity

Authors: Zhang, Yi; Zhou, Zhiwei; Jin, Hua; Hu, Chengbin; He, Zhixu; Yu, Zhiling; Ko, Robert K.M.; Yang, Tianxin; Zhang, Xueji; Pan, Siyuan; Zhou, Shufeng

Year: 2015

Venue: Theses

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68317

Thesis Therapeutic opportunities for senolysis in cardiovascular disease

Sweeney, Mark; Cook, Stuart A; Gil, Jesus · 2022 · Imperial College London · DOI

Full title: Therapeutic opportunities for senolysis in cardiovascular disease

Authors: Sweeney, Mark; Cook, Stuart A; Gil, Jesus

Year: 2022

Venue: Imperial College London

DOI: https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000746645500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis p53-mediated Senescent Neurons Trigger Apoptosis of Healthy Bystanders by Modulating the Metabolic Microenvironment in the Brain

Herrup, Karl LIFS; Chow, Hei Man · 2016 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: p53-mediated Senescent Neurons Trigger Apoptosis of Healthy Bystanders by Modulating the Metabolic Microenvironment in the Brain

Authors: Herrup, Karl LIFS; Chow, Hei Man

Year: 2016

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-84527

Thesis Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer

Haston, Scott; Gonzalez-Gualda, Estela; Morsil, Samir et al. · 2023 · Imperial College London · DOI

Full title: Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer

Authors: Haston, Scott; Gonzalez-Gualda, Estela; Morsil, Samir; Ge, Jianfeng; Reen, Virinder; Calderwood, Alexander; Moutsopoulos, Ilias; Panousopoulos, Leonidas; Deletc, Polina; Carreno, Gabriela; Guiho, Romain; Manshaei, Saba; Gonzalez-Meljem, Jose Mario; Lim, Hui Yuan; Simpson, Daniel J; Birch, Jodie; Pallikonda, Husayn A; Chandra, Tamir; Macias, David; Doherty, Gary J; Rassl, Doris M; Rintoul, Robert C; Signore, Massimo; Mohorianu, Irina; Akbar, Arne N; Gil, Jesus; Munoz-Espín, Daniel; Martinez-Barbera, Juan Pedro

Year: 2023

Venue: Imperial College London

DOI: https://www.sciencedirect.com/science/article/pii/S1535610823001721?via%3Dihub

Thesis Genetic screens identify novel liabilities of senescent cells

McHugh, Domhnall Seamus · 2023 · Imperial College London · DOI

Full title: Genetic screens identify novel liabilities of senescent cells

Authors: McHugh, Domhnall Seamus

Year: 2023

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/104580

Thesis 3-Deazaadenosine alleviates senescence to promote cellular fitness and cell therapy efficiency in mice

Guerrero, Ana; Innes, Andrew J; Roux, Pierre-François et al. · 2022 · Imperial College London · DOI

Full title: 3-Deazaadenosine alleviates senescence to promote cellular fitness and cell therapy efficiency in mice

Authors: Guerrero, Ana; Innes, Andrew J; Roux, Pierre-François; Buisman, Sonja C; Jung, Johannes; Ortet, Laura; Moiseeva, Victoria; Wagner, Verena; Robinson, Lucas; Ausema, Albertina; Potapova, Anna; Perdiguero, Eusebio; Weersing, Ellen; Aarts, Marieke; Martin, Nadine; Wuestefeld, Torsten; Muñoz-Cánoves, Pura; de Haan, Gerald; Bischof, Oliver; Gil, Jesús

Year: 2022

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/100501

Thesis Eliminating senescent cells can promote pulmonary hypertension development and progression

Born, Emmanuelle; Lipskaia, Larissa; Breau, Marielle et al. · 2023 · Imperial College London · DOI

Full title: Eliminating senescent cells can promote pulmonary hypertension development and progression

Authors: Born, Emmanuelle; Lipskaia, Larissa; Breau, Marielle; Houssaini, Amal; Beaulieu, Delphine Paulette; Marcos, Elizabeth; Pierre, Remi; Do Cruzeiro, Marcio; Lefevre, Marine; Derumeaux, Genevieve; Bulavin, Dmitry V; Delcroix, Marion; Quarck, Rozenn; Reen, Virinder; Gil, Jesus; Bernard, David; Flaman, Jean-Michel; Adnot, Serge; Abid, Shariq

Year: 2023

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/36515093

Thesis Reshaping of the tumor microenvironment by cellular senescence: an opportunity for senotherapies

Gil, Jesus; D’Ambrosio, Mariantonietta · 2023 · Imperial College London · DOI

Full title: Reshaping of the tumor microenvironment by cellular senescence: an opportunity for senotherapies

Authors: Gil, Jesus; D’Ambrosio, Mariantonietta

Year: 2023

Venue: Imperial College London

DOI: https://www.sciencedirect.com/science/article/pii/S1534580723002435

Thesis Drug repurposing for aging research using model organisms

Ziehm, Matthias; Kaur, Satwant; Ivanov, Dobril K et al. · 2024 · Imperial College London · DOI

Full title: Drug repurposing for aging research using model organisms

Authors: Ziehm, Matthias; Kaur, Satwant; Ivanov, Dobril K; Ballester, Pedro J; Marcus, David; Partridge, Linda; Thornton, Janet M

Year: 2024

Venue: Imperial College London

DOI: https://doi.org/10.1111%2Facel.12626

Thesis Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease

Li, Chenfei; Liu, Qi; Chang, Qing et al. · 2024 · Imperial College London · DOI

Full title: Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease

Authors: Li, Chenfei; Liu, Qi; Chang, Qing; Xie, Meiqin; Weng, Jiali; Wang, Xiaohui; Li, Mengnan; Chen, Jiani; Huang, Yan; Yang, Xiaohua; Wang, Kai; Zhang, Na; Chung, Kian Fan; Adcock, Ian M; Zhang, Hai; Li, Feng

Year: 2024

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/38110986

Thesis Investigation of macrophage immunosenescence in chronic obstructive pulmonary disease

Hassibi, Shyreen · 2024 · Imperial College London · DOI

Full title: Investigation of macrophage immunosenescence in chronic obstructive pulmonary disease

Authors: Hassibi, Shyreen

Year: 2024

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/110592

Thesis An indocyanine green‐based nanoprobe for in vivo detection of cellular senescence

Baker, Andrew G; Hartono, Muhamad; Ou, Hui‐Ling et al. · 2025 · Imperial College London · DOI

Full title: An indocyanine green‐based nanoprobe for in vivo detection of cellular senescence

Authors: Baker, Andrew G; Hartono, Muhamad; Ou, Hui‐Ling; Popov, Andrea Bistrović; Brown, Emma L; Joseph, James; Golinska, Monika; González‐Gualda, Estela; Macias, David; Ge, Jianfeng; Denholm, Mary; Morsli, Samir; Sanghera, Chandan; Else, Thomas R; Greer, Heather F; Vernet, Aude; Bohndiek, Sarah E; Muñoz‐Espín, Daniel; Fruk, Ljiljana

Year: 2025

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/38622059

Thesis Metabolic pathways in immune senescence and inflammaging: novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology

Roth-Walter, F; Adcock, IM; Benito-Villalvilla, C et al. · 2024 · Imperial College London · DOI

Full title: Metabolic pathways in immune senescence and inflammaging: novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology

Authors: Roth-Walter, F; Adcock, IM; Benito-Villalvilla, C; Bianchini, R; Bjermer, L; Caramori, G; Cari, L; Chung, KF; Diamant, Z; Eguiluz-Gracia, I; Knol, EF; Jesenak, M; Levi-Schaffer, F; Nocentini, G; O'Mahony, L; Palomares, O; Redegeld, F; Sokolowska, M; Van Esch, BCAM; Stellato, C

Year: 2024

Venue: Imperial College London

DOI: https://onlinelibrary.wiley.com/doi/10.1111/all.15977

Thesis SMARCA4 regulates the NK-mediated killing of senescent cells

Reen, Virinder; D'Ambrosio, Mariantonietta; Søgaard, Pia Pernille et al. · 2024 · Imperial College London · DOI

Full title: SMARCA4 regulates the NK-mediated killing of senescent cells

Authors: Reen, Virinder; D'Ambrosio, Mariantonietta; Søgaard, Pia Pernille; Tyson, Katie; Leeke, Bryony J; Clément, Isabelle; Dye, Isabel CA; Pombo, Joaquim; Kuba, Adam; Lan, Yemin; Burr, Joanna; Bomann, Ida C; Kalyva, Maria; Birch, Jodie; Khadayate, Sanjay; Young, George; Provencher, Diane; Mes-Masson, Anne-Marie; Vernia, Santiago; McGranahan, Nicholas; Brady, Hugh JM; Rodier, Francis; Nativio, Raffaella; Percharde, Michelle; McNeish, Iain A; Gil, Jesús

Year: 2024

Venue: Imperial College London

DOI: https://www.science.org/doi/10.1126/sciadv.adn2811

Thesis New drugs under development for COPD

Uwagboe, Isabel; Adcock, Ian M; Lo Bello, Federica et al. · 2024 · Imperial College London · DOI

Full title: New drugs under development for COPD

Authors: Uwagboe, Isabel; Adcock, Ian M; Lo Bello, Federica; Caramori, Gaetano; Mumby, Sharon

Year: 2024

Venue: Imperial College London

DOI: https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000828452300008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb

Thesis Senescence as a therapeutic target in cancer and age-related diseases

Gil, jesus · 2024 · Imperial College London · DOI

Full title: Senescence as a therapeutic target in cancer and age-related diseases

Authors: Gil, jesus

Year: 2024

Venue: Imperial College London

DOI: https://www.nature.com/articles/s41573-024-01074-4

Thesis Photoacoustic polydopamine-indocyanine green (PDA-ICG) nanoprobe for detection of senescent cells

Hartono, Muhamad; Baker, Andrew G; Else, Thomas R et al. · 2025 · Imperial College London · DOI

Full title: Photoacoustic polydopamine-indocyanine green (PDA-ICG) nanoprobe for detection of senescent cells

Authors: Hartono, Muhamad; Baker, Andrew G; Else, Thomas R; Evtushenko, Alexander S; Bohndiek, Sarah E; Muñoz-Espín, Daniel; Fruk, Ljiljana

Year: 2025

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/39604512

Thesis Ageing: out with the old

Gil, J; Withers, DJ · 2016 · Imperial College London · DOI

Full title: Ageing: out with the old

Authors: Gil, J; Withers, DJ

Year: 2016

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/34126

Thesis mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

Herranz, N; Gallage, S; Mellone, M et al. · 2016 · Imperial College London · DOI

Full title: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

Authors: Herranz, N; Gallage, S; Mellone, M; Wuestefeld, T; Klotz, S; Hanley, CJ; Raguz, S; Acosta, JC; Innes, AJ; Banito, A; Georgilis, A; Montoya, A; Wolter, K; Dharmalingam, G; Faull, P; Carroll, T; Martinez-Barbera, JP; Cutillas, P; Reisinger, F; Heikenwalder, M; Miller, RA; Withers, D; Zender, L; Thomas, GJ; Gill, J

Year: 2016

Venue: Imperial College London

DOI: https://www.nature.com/articles/ncb3225

Thesis Membrane transporter progressive ankylosis protein homologue (ANKH/Ank) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation, and ageing

James, Emma Naomi; Teh, Muy-Teck; Li, Yufeng et al. · 2025 · Imperial College London · DOI

Full title: Membrane transporter progressive ankylosis protein homologue (ANKH/Ank) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation, and ageing

Authors: James, Emma Naomi; Teh, Muy-Teck; Li, Yufeng; Wagner-Bock, Christine; Al-Khateeb, Zahra Falah; Karen-Ng, Lee Peng; Roberts, Terry; Synchyshyn, Linnea; Lewis, Amy; O’Loghlen, Ana; Silver, Andrew; Michael-Titus, Adina Teodora; Bennett, Mark; Bundy, Jacob Guy; Mycielska, Maria Elzbieta; Parkinson, Eric Kenneth

Year: 2025

Venue: Imperial College London

DOI: https://hdl.handle.net/10044/1/121643

Thesis Identifying novel strategies to promote NK cell-mediated clearance of senescent cells

Reen, Virinder · 2025 · Imperial College London · DOI

Full title: Identifying novel strategies to promote NK cell-mediated clearance of senescent cells

Authors: Reen, Virinder

Year: 2025

Venue: Imperial College London

DOI: https://hdl.handle.net/10044/1/122955

Thesis A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers

Libri, V; Brown, AP; Gambarota, G et al. · 2018 · Theses · DOI

Full title: A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers

Authors: Libri, V; Brown, AP; Gambarota, G; Haddad, G; Shields, GS; Dawes, H; Pinato, DJ; Hoffman, E; Elliot, PJ; Vlasuk, GP; Jacobson, E; Wilkins, MR; Matthews, PM

Year: 2018

Venue: Theses

DOI: http://hdl.handle.net/10044/1/57628

Thesis Cellular senescence: The sought or the unwanted?

Sun, Yu; Coppé, Jean-Philippe; Lam, EW · 2018 · Imperial College London · DOI

Full title: Cellular senescence: The sought or the unwanted?

Authors: Sun, Yu; Coppé, Jean-Philippe; Lam, EW

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/63920

Thesis Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease

Birch, Jodie; Barnes, Peter J; Passos, Joao F · 2017 · Imperial College London · DOI

Full title: Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease

Authors: Birch, Jodie; Barnes, Peter J; Passos, Joao F

Year: 2017

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/28987319

Thesis The senescence-associated secretory phenotype regulates the growth behavior of pediatric pilocytic astrocytoma

Buhl, Juliane · 2019 · Heidelberg University · DOI

Full title: The senescence-associated secretory phenotype regulates the growth behavior of pediatric pilocytic astrocytoma

Authors: Buhl, Juliane

Year: 2019

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/26671/1/PhD%20thesis%20JBuhl.pdf

Thesis The Role of Bone Marrow Mesenchymal Stromal Cell Senescence in Multiple Myeloma

Plakhova, Natalya · 2022 · University of Adelaide · DOI

Full title: The Role of Bone Marrow Mesenchymal Stromal Cell Senescence in Multiple Myeloma

Authors: Plakhova, Natalya

Year: 2022

Venue: University of Adelaide

DOI: https://hdl.handle.net/2440/138626

Thesis Evaluating the Role of Bone Marrow Microenvironment in the Pathogenesis of Therapy-related Myeloid Neoplasms

Kutyna, Monika Maria · 2022 · University of Adelaide · DOI

Full title: Evaluating the Role of Bone Marrow Microenvironment in the Pathogenesis of Therapy-related Myeloid Neoplasms

Authors: Kutyna, Monika Maria

Year: 2022

Venue: University of Adelaide

DOI: https://hdl.handle.net/2440/137174

Thesis A Human Conditionally Immortalized Proximal Tubule Epithelial Cell Line as a Novel Model for Studying Senescence and Response to Senolytics

Yang, Yi; Mihajlovic, Milos; Valentijn, Floris et al. · 2022 · Utrecht University · DOI

Full title: A Human Conditionally Immortalized Proximal Tubule Epithelial Cell Line as a Novel Model for Studying Senescence and Response to Senolytics

Authors: Yang, Yi; Mihajlovic, Milos; Valentijn, Floris; Nguyen, Tri Q; Goldschmeding, Roel; Masereeuw, Rosalinde

Year: 2022

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/420657

Thesis Protein-Bound Uremic Toxins in Senescence and Kidney Fibrosis

Yang, Yi; Mihajlovic, Milos; Masereeuw, Rosalinde · 2023 · Utrecht University · DOI

Full title: Protein-Bound Uremic Toxins in Senescence and Kidney Fibrosis

Authors: Yang, Yi; Mihajlovic, Milos; Masereeuw, Rosalinde

Year: 2023

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/438121

Thesis Developing a Senomorphic Treatment Strategy in Osteoarthritis

Chen, Yu-Hsiu · 2022 · Duke University · DOI

Full title: Developing a Senomorphic Treatment Strategy in Osteoarthritis

Authors: Chen, Yu-Hsiu

Year: 2022

Venue: Duke University

DOI: https://hdl.handle.net/10161/25828

Thesis Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology

Roth-Walter, F; Adcock, I M; Benito-Villalvilla, C et al. · 2024 · Utrecht University · DOI

Authors: Roth-Walter, F; Adcock, I M; Benito-Villalvilla, C; Bianchini, R; Bjermer, L; Caramori, G; Cari, L; Chung, K F; Diamant, Z; Eguiluz-Gracia, I; Knol, E F; Jesenak, M; Levi-Schaffer, F; Nocentini, G; O'Mahony, L; Palomares, O; Redegeld, F; Sokolowska, M; Van Esch, B C A M; Stellato, C

Year: 2024

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/453738

Thesis Modulating type two alveolar epithelial senescence in acute lung injury and fibrosis

Emanuel, Philip · 2021 · The University of Edinburgh · DOI

Full title: Modulating type two alveolar epithelial senescence in acute lung injury and fibrosis

Authors: Emanuel, Philip

Year: 2021

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/37827

Thesis Understanding the heterogeneity of senescence and ageing at the single-cell level

Rattanavirotkul, Nattaphong · 2020 · The University of Edinburgh · DOI

Full title: Understanding the heterogeneity of senescence and ageing at the single-cell level

Authors: Rattanavirotkul, Nattaphong

Year: 2020

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/36718

Thesis Interconnections between apoptotic, autophagic and necrotic pathways: Implications for cancer therapy development

Jain, MV; Paczulla, AM; Klonisch, T et al. · 2025 · University of Basel - edoc Repository · DOI

Full title: Interconnections between apoptotic, autophagic and necrotic pathways: Implications for cancer therapy development

Authors: Jain, MV; Paczulla, AM; Klonisch, T; Dimgba, FN; Rao, SB; Roberg, K; Schweizer, F; Lengerke, C; Davoodpour, P; Palicharla, VR; Maddika, S; Łos, M

Year: 2025

Venue: University of Basel - edoc Repository

DOI: https://hdl.handle.net/20.500.14716/29069

Thesis Targeting epithelial senescence to augment renal repair

O’Sullivan, Eoin Daniel · 2022 · The University of Edinburgh · DOI

Full title: Targeting epithelial senescence to augment renal repair

Authors: O’Sullivan, Eoin Daniel

Year: 2022

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/38650

Thesis Discovery of novel renal epithelial senescence associated biomarkers

Baird, David Paul · 2023 · The University of Edinburgh · DOI

Full title: Discovery of novel renal epithelial senescence associated biomarkers

Authors: Baird, David Paul

Year: 2023

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/41086

Thesis Reprogramming small-molecule activity through chemical conjugation: a chemical biology approach to diseases

Wang, Siyi · 2025 · Theses · DOI

Full title: Reprogramming small-molecule activity through chemical conjugation: a chemical biology approach to diseases

Authors: Wang, Siyi

Year: 2025

Venue: Theses

DOI: https://escholarship.org/uc/item/9nx2b74w

Thesis Cyclin-dependent kinase inhibitor drugs drive neutrophil granulocyte apoptosis by transcriptional inhibition of the key survival protein MCL-1

Leitch, Andrew Edward · 2012 · The University of Edinburgh · DOI

Full title: Cyclin-dependent kinase inhibitor drugs drive neutrophil granulocyte apoptosis by transcriptional inhibition of the key survival protein MCL-1

Authors: Leitch, Andrew Edward

Year: 2012

Venue: The University of Edinburgh

DOI: http://hdl.handle.net/1842/5922

Thesis Characterising the influence of resident cell senescence on macrophage phenotype

Campbell, Ross Alexander · 2024 · The University of Edinburgh · DOI

Full title: Characterising the influence of resident cell senescence on macrophage phenotype

Authors: Campbell, Ross Alexander

Year: 2024

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/42255

Thesis The Role of Endothelial Senescence and Extracellular Vesicles in Blood-Brain Barrier Vulnerability and Alzheimer’s Disease Pathogenesis

Hogans, Ryan Edward · 2025 · University of California, Davis · DOI

Full title: The Role of Endothelial Senescence and Extracellular Vesicles in Blood-Brain Barrier Vulnerability and Alzheimer’s Disease Pathogenesis

Authors: Hogans, Ryan Edward

Year: 2025

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/9qf1r4qc

Thesis In vivo characterisation of Zoledronate, a drug which delays or reverses tissue ageing.

Chen, Zhengqi · 2020 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: In vivo characterisation of Zoledronate, a drug which delays or reverses tissue ageing.

Authors: Chen, Zhengqi

Year: 2020

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/27792/1/Zhengqi%20Chen_%20Thesis_%20%E4%BF%AE%E6%94%B9%E7%89%88.docx

Thesis Senescentní buňky a jejich eliminace imunitním systémem

Novotný, Ondřej · 2020 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Senescentní buňky a jejich eliminace imunitním systémem

Authors: Novotný, Ondřej

Year: 2020

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/116509

Thesis Navigation into new medicinal application of vanadium-based agents as antagonist against senescence

Cao, Zhenkun; 曹振坤 · 2023 · University of Hong Kong · DOI

Full title: Navigation into new medicinal application of vanadium-based agents as antagonist against senescence

Authors: Cao, Zhenkun; 曹振坤

Year: 2023

Venue: University of Hong Kong

DOI: https://hub.hku.hk/handle/10722/325741

Thesis Latest advances in aging research and drug discovery

Bakula, Daniela; Ablasser, Andrea; Aguzzi, Adriano et al. · 2019 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Latest advances in aging research and drug discovery

Authors: Bakula, Daniela; Ablasser, Andrea; Aguzzi, Adriano; Antebi, Adam; Barzilai, Nir; Bittner, Martin-Immanuel; Jensen, Martin Borch; Calkhoven, Cornelis F.; Chen, Danica; de Grey, Aubrey D. N. J.; Feige, Jerome N.; Georgievskaya, Anastasia; Gladyshev, Vadim N.; Golato, Tyler; Gudkov, Andrei V.; Hoppe, Thorsten; Kaeberlein, Matt; Katajisto, Pekka; Kennedy, Brian K.; Lal, Unmesh; Martin-Villalba, Ana; Moskalev, Alexey A.; Ozerov, Ivan; Petr, Michael A.; Reason; Rubinsztein, David C.; Tyshkovskiy, Alexander; Vanhaelen, Quentin; Zhavoronkov, Alex; Scheibye-Knudsen, Morten

Year: 2019

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/164065

Thesis Cytokiny ve vzájemných interakcích mezi senescentními a myeloidními buňkami.

Lvova, Yuliia · 2025 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Cytokiny ve vzájemných interakcích mezi senescentními a myeloidními buňkami.

Authors: Lvova, Yuliia

Year: 2025

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/199517

Thesis Injectable Senolytic Hydrogel Depot for the Clearance of Senescent Cells

Garau Paganella, Lorenza; Bovone, Giovanni; id_orcid0000-0002-8508-0737 et al. · 2025 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Injectable Senolytic Hydrogel Depot for the Clearance of Senescent Cells

Year: 2025

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/784328

Thesis Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice

Zumerle, Sara; Sarill, Miles; Saponaro, Miriam et al. · 2024 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice

Year: 2024

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/682234

Thesis Regulation and function of MYBBP1A in cellular senescence and pathogenesis of head and neck cancer

George, Babitha · 2015 · Heidelberg University · DOI

Full title: Regulation and function of MYBBP1A in cellular senescence and pathogenesis of head and neck cancer

Authors: George, Babitha

Year: 2015

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/18943/1/Babitha%20George_PhD%20Thesis.pdf

Thesis Hyperforin induces senescence in endothelial and tumor cells

Sabouri Khameneh, Haniyeh · 2017 · Heidelberg University · DOI

Full title: Hyperforin induces senescence in endothelial and tumor cells

Authors: Sabouri Khameneh, Haniyeh

Year: 2017

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/21958/1/Doktorarbeit_Hani_Final_JPS_Jan15-2.pdf

Thesis Unravelling the Influence of Donor Age on Renal Allograft Survival

Sarwar, Attia · 2024 · Freie Universität Berlin (Refubium) · DOI

Full title: Unravelling the Influence of Donor Age on Renal Allograft Survival

Authors: Sarwar, Attia

Year: 2024

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/44369

Thesis Efeitos da combinação senolítica dasastinibe e quercetina na periodontite induzida em ratos

Santos, Yuri Cavalcante [UNESP] · 2025 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Efeitos da combinação senolítica dasastinibe e quercetina na periodontite induzida em ratos

Authors: Santos, Yuri Cavalcante [UNESP]

Year: 2025

Venue: Universidade Estadual Paulista (UNESP)

DOI: https://hdl.handle.net/11449/315133

Thesis Phosphoproteome dynamics in onset and maintenance of oncogene-induced senescence

de Graaf, Erik L; Kaplon, Joanna; Zhou, Houjiang et al. · 2014 · Utrecht University · DOI

Full title: Phosphoproteome dynamics in onset and maintenance of oncogene-induced senescence

Authors: de Graaf, Erik L; Kaplon, Joanna; Zhou, Houjiang; Heck, Albert J R; Peeper, Daniel S; Altelaar, A.F.M.

Year: 2014

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/308024

Thesis Investigating the role of microglial senescence in central nervous system injury and regeneration

Kent, Sarah Alison · 2024 · The University of Edinburgh · DOI

Full title: Investigating the role of microglial senescence in central nervous system injury and regeneration

Authors: Kent, Sarah Alison

Year: 2024

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/41704

Thesis Impaired signaling in senescing T cells: investigation of the role of reactive oxygen species using microfluidic platforms and computational modeling

Rivet, Catherine-Aurélie · 2013 · Georgia Institute of Technology · DOI

Full title: Impaired signaling in senescing T cells: investigation of the role of reactive oxygen species using microfluidic platforms and computational modeling

Authors: Rivet, Catherine-Aurélie

Year: 2013

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/49020

Thesis Targeting Neuroinflammation as a Therapeutic Strategy for Alzheimer's Disease: Mechanisms, Drug Candidates, and New Opportunities

Fu, Wing-Yu LIFS; Wang, Xiujiao; Ip, Nancy Yuk-yu · 2019 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Targeting Neuroinflammation as a Therapeutic Strategy for Alzheimer's Disease: Mechanisms, Drug Candidates, and New Opportunities

Authors: Fu, Wing-Yu LIFS; Wang, Xiujiao; Ip, Nancy Yuk-yu

Year: 2019

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-96073

Thesis Coupling shRNA screens with single-cell RNA-Seq identifies a dual role for mTOR in reprogramming-induced senescence

Aarts, M; Georgilis, A; Beniazza, M et al. · 2017 · Imperial College London · DOI

Full title: Coupling shRNA screens with single-cell RNA-Seq identifies a dual role for mTOR in reprogramming-induced senescence

Authors: Aarts, M; Georgilis, A; Beniazza, M; Beolchi, P; Banito, A; Carroll, T; Kulisic, M; Kaemena, DF; Dharmalingam, G; Martin, N; Reik, W; Zuber, J; Kaji, K; Chandra, T; Gil, J

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/52022

Thesis Shedding light on developmental drugs for idiopathic pulmonary fibrosis

Spagnolo, Paolo; Bonella, Francesco; Ryerson, Christopher J et al. · 2020 · Imperial College London · DOI

Full title: Shedding light on developmental drugs for idiopathic pulmonary fibrosis

Authors: Spagnolo, Paolo; Bonella, Francesco; Ryerson, Christopher J; Tzouvelekis, Argyris; Maher, Toby M

Year: 2020

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/32538186

Thesis Imaging glycogenesis as a novel biomarker of drug-induced senescence/quiescence

Chen, Cen · 2022 · Imperial College London · DOI

Full title: Imaging glycogenesis as a novel biomarker of drug-induced senescence/quiescence

Authors: Chen, Cen

Year: 2022

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/96235

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2. Data Extraction

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Paper

The therapeutic potential of resveratrol: a review of clinical trials

Berman, Adi Y., Motechin, Rachel A., Wiesenfeld, Maia Y., Holz, Marina K. · 2017

Full title: The therapeutic potential of resveratrol: a review of clinical trials

Authors: Berman, Adi Y., Motechin, Rachel A., Wiesenfeld, Maia Y., Holz, Marina K.

DOI: https://doi.org/10.1038/s41698-017-0038-6

Paper

Editorial: Intra/Extracellular Dynamics of the Respiratory System and Global Airway Disease

Guan, Wei‐jie; Tran, Thai; Wang, De Yun · 2020

Full title: Editorial: Intra/Extracellular Dynamics of the Respiratory System and Global Airway Disease

Authors: Guan, Wei‐jie; Tran, Thai; Wang, De Yun

DOI: https://doi.org/10.3389/fcell.2020.00523

Paper

Programmed Cell Senescence in the Mouse Developing Spinal Cord and Notochord

J. Domínguez-Bautista; Pilar Sarah Acevo-Rodríguez; S. Castro-Obregón · 2020

Full title: Programmed Cell Senescence in the Mouse Developing Spinal Cord and Notochord

Authors: J. Domínguez-Bautista; Pilar Sarah Acevo-Rodríguez; S. Castro-Obregón

DOI: https://doi.org/10.3389/fcell.2021.587096

Paper

The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice.

Sharma, Anuj K; Roberts, Rachel L; Benson, Reginald D et al. · 2020

Full title: The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice.

Authors: Sharma, Anuj K; Roberts, Rachel L; Benson, Reginald D; Pierce, Jessica L; Yu, Kanglun; Hamrick, Mark W; McGee-Lawrence, Meghan E

DOI: https://doi.org/10.3389/fcell.2020.00354

Paper

Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities

Ramasamy, Thamil Selvee; Yee, Yong Mei; Khan, Ilyas M. · 2021

Full title: Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities

Authors: Ramasamy, Thamil Selvee; Yee, Yong Mei; Khan, Ilyas M.

DOI: https://doi.org/10.3389/fcell.2021.625497

Paper

Elimination of Senescent Cells by Senolytics Facilitates Bony Endplate Microvessel Formation and Mitigates Disc Degeneration in Aged Mice.

Chen, Bolin; Zhu, Runjiu; Hu, Hao et al. · 2022

Full title: Elimination of Senescent Cells by Senolytics Facilitates Bony Endplate Microvessel Formation and Mitigates Disc Degeneration in Aged Mice.

Authors: Chen, Bolin; Zhu, Runjiu; Hu, Hao; Zhan, Mingbin; Wang, Tingxuan; Huang, Fangli; Wei, Fuxin; Chai, Yu; Ling, Zemin; Zou, Xuenong

DOI: https://doi.org/10.3389/fcell.2022.853688

Paper

Geroprotectors and Skeletal Health: Beyond the Headlines

Rayson, Alexandra; Boudiffa, Maya; Naveed, Maneeha et al. · 2022

Full title: Geroprotectors and Skeletal Health: Beyond the Headlines

Authors: Rayson, Alexandra; Boudiffa, Maya; Naveed, Maneeha; Griffin, Jon; Dall’Ara, Enrico; Bellantuono, Ilaria

DOI: https://doi.org/10.3389/fcell.2022.682045

Paper

IL-1 and senescence: Friends and foe of EGFR neutralization and immunotherapy.

Romaniello, Donatella; Gelfo, Valerio; Pagano, Federica et al. · 2022

Full title: IL-1 and senescence: Friends and foe of EGFR neutralization and immunotherapy.

Authors: Romaniello, Donatella; Gelfo, Valerio; Pagano, Federica; Sgarzi, Michela; Morselli, Alessandra; Girone, Cinzia; Filippini, Daria Maria; D'Uva, Gabriele; Lauriola, Mattia

DOI: https://doi.org/10.3389/fcell.2022.1083743

Paper

Editorial: Cellular Senescence: Causes, Consequences and Therapeutic Opportunities

P. Wong · 2022

Full title: Editorial: Cellular Senescence: Causes, Consequences and Therapeutic Opportunities

Authors: P. Wong

DOI: https://doi.org/10.3389/fcell.2022.884910

Paper

Fibroblast Senescence in Idiopathic Pulmonary Fibrosis

Yifan Lin; Zhi-hao Xu · 2020

Full title: Fibroblast Senescence in Idiopathic Pulmonary Fibrosis

Authors: Yifan Lin; Zhi-hao Xu

DOI: https://doi.org/10.3389/fcell.2020.593283

Paper

Modern Concepts in Cardiovascular Disease: Inflamm-Aging

Puspitasari, Yustina M.; Ministrini, Stefano; Schwarz, Lena et al. · 2022

Full title: Modern Concepts in Cardiovascular Disease: Inflamm-Aging

Authors: Puspitasari, Yustina M.; Ministrini, Stefano; Schwarz, Lena; Karch, Caroline; Liberale, Luca; Camici, Giovanni G.

DOI: https://doi.org/10.3389/fcell.2022.882211

Paper

Mitochondrial dysfunction and alveolar type II epithelial cell senescence: The destroyer and rescuer of idiopathic pulmonary fibrosis.

Liu, Suqi; Xi, Qian; Li, Xuannian et al. · 2025

Full title: Mitochondrial dysfunction and alveolar type II epithelial cell senescence: The destroyer and rescuer of idiopathic pulmonary fibrosis.

Authors: Liu, Suqi; Xi, Qian; Li, Xuannian; Liu, Huaman

DOI: https://doi.org/10.3389/fcell.2025.1535601

Paper

Porphyromonas gingivalis Provokes Exosome Secretion and Paracrine Immune Senescence in Bystander Dendritic Cells

Ranya Elsayed; M. Elashiry; Yutao Liu et al. · 2021

Full title: Porphyromonas gingivalis Provokes Exosome Secretion and Paracrine Immune Senescence in Bystander Dendritic Cells

Authors: Ranya Elsayed; M. Elashiry; Yutao Liu; Ahmed R. El-Awady; M. Hamrick; C. Cutler

DOI: https://doi.org/10.3389/fcimb.2021.669989

Paper

Differential responses to the combination of navitoclax and venetoclax with doxorubicin in murine models of triple negative breast cancer

Homood M As Sobeai; Abdulrahman M. Alanazi; Faisal N Alotaibi et al. · 2026

Full title: Differential responses to the combination of navitoclax and venetoclax with doxorubicin in murine models of triple negative breast cancer

DOI: https://doi.org/10.3389/fcell.2026.1661424

Paper

Defining melanoma combination therapies that provide senolytic sensitivity in human melanoma cells

D. Tchelougou; N. Malaquin; Guillaume B Cardin et al. · 2023

Full title: Defining melanoma combination therapies that provide senolytic sensitivity in human melanoma cells

Authors: D. Tchelougou; N. Malaquin; Guillaume B Cardin; Jordan Desmul; Simon Turcotte; F. Rodier

DOI: https://doi.org/10.3389/fcell.2024.1368711

Paper

Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis.

Zhou, Shenghui; Zhu, Jiaojiao; Zhou, Ping-Kun et al. · 2022

Full title: Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis.

Authors: Zhou, Shenghui; Zhu, Jiaojiao; Zhou, Ping-Kun; Gu, Yongqing

DOI: https://doi.org/10.3389/fcell.2022.999600

Paper

The impact of cellular senescence on aging skeletal muscle.

Kamal, Michael; Bevington, Ryan; Johnson, Amanda et al. · 2025

Full title: The impact of cellular senescence on aging skeletal muscle.

Authors: Kamal, Michael; Bevington, Ryan; Johnson, Amanda; Parise, Gianni

DOI: https://doi.org/10.3389/fcell.2025.1719279

Paper

Cellular senescence and abdominal aortic aneurysm: From pathogenesis to therapeutics

Wang, Ding; Hao, Xinyu; Jia, Longyuan et al. · 2022

Full title: Cellular senescence and abdominal aortic aneurysm: From pathogenesis to therapeutics

Authors: Wang, Ding; Hao, Xinyu; Jia, Longyuan; Jing, Yuchen; Jiang, Bo; Xin, Shijie

DOI: https://doi.org/10.3389/fcvm.2022.999465

Paper

Cardiotoxicity of anti-cancer drugs: cellular mechanisms and clinical implications

Kwok, Cecilia; Nolan, Mark · 2023

Full title: Cardiotoxicity of anti-cancer drugs: cellular mechanisms and clinical implications

Authors: Kwok, Cecilia; Nolan, Mark

DOI: https://doi.org/10.3389/fcvm.2023.1150569

Paper

Obesity-related kidney disease: Beyond hypertension and insulin-resistance

Arabi, Tarek Ziad; Shafqat, Areez; Sabbah, Belal Nedal et al. · 2023

Full title: Obesity-related kidney disease: Beyond hypertension and insulin-resistance

Authors: Arabi, Tarek Ziad; Shafqat, Areez; Sabbah, Belal Nedal; Fawzy, Nader A.; Shah, H. A.; Abdulkader, Humzah; Razak, Adhil; Sabbah, Ahmad Nedal; Arabi, Ziad

DOI: https://doi.org/10.3389/fendo.2022.1095211

Paper

Senescence-Associated Secretory Phenotype as a Hinge Between Cardiovascular Diseases and Cancer

Banerjee, Priyanka; Kotla, Sivareddy; Velatooru, Loka Reddy et al. · 2021

Full title: Senescence-Associated Secretory Phenotype as a Hinge Between Cardiovascular Diseases and Cancer

DOI: https://doi.org/10.3389/fcvm.2021.763930

Paper

Oral Senescence: From Molecular Biology to Clinical Research

E. K. Parkinson; S. Prime · 2022

Full title: Oral Senescence: From Molecular Biology to Clinical Research

Authors: E. K. Parkinson; S. Prime

DOI: https://doi.org/10.3389/fdmed.2022.822397

Paper

Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype

Chisaka Kuehnemann; K. Hu; Kayla Butera et al. · 2022

Full title: Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype

Authors: Chisaka Kuehnemann; K. Hu; Kayla Butera; Sandip K. Patel; J. Bons; B. Schilling; Cristina Aguayo-Mazzucato; Christopher D. Wiley

DOI: https://doi.org/10.3389/fendo.2022.935106

Paper

- **DOI:** 10.3389/fendo.2022.869414 - **Authors:** T. Murakami, N. Inagaki, H. Kondoh - **Year:** 2022 - **Journal:** Frontiers in Endocrinology

T. Murakami; N. Inagaki; H. Kondoh · 2022

Full title: - **DOI:** 10.3389/fendo.2022.869414 - **Authors:** T. Murakami, N. Inagaki, H. Kondoh - **Year:** 2022 - **Journal:** Frontiers in Endocrinology

Authors: T. Murakami; N. Inagaki; H. Kondoh

DOI: https://doi.org/10.3389/fendo.2022.869414

Paper

Cellular senescence of renal tubular epithelial cells in renal fibrosis

Zhang, Junqing; Li, Yingying; Zhang, Xueyan et al. · 2023

Full title: Cellular senescence of renal tubular epithelial cells in renal fibrosis

Authors: Zhang, Junqing; Li, Yingying; Zhang, Xueyan; Tian, Zenghui; Liu, Cheng; Wang, Shitao; Zhang, Farong

DOI: https://doi.org/10.3389/fendo.2023.1085605

Paper

Mechanisms and therapeutic strategies linking mesenchymal stem cells senescence to osteoporosis.

Tong, Yashuang; Tu, Yulin; Wang, Jingying et al. · 2025

Full title: Mechanisms and therapeutic strategies linking mesenchymal stem cells senescence to osteoporosis.

Authors: Tong, Yashuang; Tu, Yulin; Wang, Jingying; Liu, Xiuyu; Su, Qian; Wang, Yanghao; Wang, Weizhou

DOI: https://doi.org/10.3389/fendo.2025.1625806

Paper

Connecting epigenetics and inflammation in vascular senescence: state of the art, biomarkers and senotherapeutics.

Fraile-Martinez, Oscar; De Leon-Oliva, Diego; Boaru, Diego Liviu et al. · 2024

Full title: Connecting epigenetics and inflammation in vascular senescence: state of the art, biomarkers and senotherapeutics.

DOI: https://doi.org/10.3389/fgene.2024.1345459

Paper

A Potential Role for Integrin-Linked Kinase in Colorectal Cancer Growth and Progression via Regulating Senescence and Immunity

Almasabi, Saleh; Ahmed, Afsar U.; Boyd, Richard L. et al. · 2021

Full title: A Potential Role for Integrin-Linked Kinase in Colorectal Cancer Growth and Progression via Regulating Senescence and Immunity

Authors: Almasabi, Saleh; Ahmed, Afsar U.; Boyd, Richard L.; Williams, Bryan

DOI: https://doi.org/10.3389/fgene.2021.638558

Paper

Age- and Tissue-Specific Expression of Senescence Biomarkers in Mice

Adam D. Hudgins; Cagdas Tazearslan; Archana Tare et al. · 2018

Full title: Age- and Tissue-Specific Expression of Senescence Biomarkers in Mice

Authors: Adam D. Hudgins; Cagdas Tazearslan; Archana Tare; Yizhou Zhu; D. Huffman; Y. Suh

DOI: https://doi.org/10.3389/fgene.2018.00059

Paper

Immune Reconstitution in the Aging Host: Opportunities for Mechanism-Based Therapy in Allogeneic Hematopoietic Cell Transplantation

Lin, Richard J.; Elias, Harold K.; Brink, Marcel R.M. van den · 2021

Full title: Immune Reconstitution in the Aging Host: Opportunities for Mechanism-Based Therapy in Allogeneic Hematopoietic Cell Transplantation

Authors: Lin, Richard J.; Elias, Harold K.; Brink, Marcel R.M. van den

DOI: https://doi.org/10.3389/fimmu.2021.674093

Paper

Accumulation of Senescent Neural Cells in Murine Lupus With Depression-Like Behavior

Yuki Saito; Maki Miyajima; Sena Yamamoto et al. · 2021

Full title: Accumulation of Senescent Neural Cells in Murine Lupus With Depression-Like Behavior

Authors: Yuki Saito; Maki Miyajima; Sena Yamamoto; Tsukasa Sato; Norihiro Miura; M. Fujimiya; Takako S. Chikenji

DOI: https://doi.org/10.3389/fimmu.2021.692321

Paper

Targeting Aging: Lessons Learned From Immunometabolism and Cellular Senescence

Martin, Dominique E.; Torrance, Blake L.; Haynes, Laura et al. · 2021

Full title: Targeting Aging: Lessons Learned From Immunometabolism and Cellular Senescence

Authors: Martin, Dominique E.; Torrance, Blake L.; Haynes, Laura; Bartley, Jenna M.

DOI: https://doi.org/10.3389/fimmu.2021.714742

Paper

The Role of Ageing and Parenchymal Senescence on Macrophage Function and Fibrosis

Campbell, Ross; Docherty, Marie-Helena; Ferenbach, David A. et al. · 2021

Full title: The Role of Ageing and Parenchymal Senescence on Macrophage Function and Fibrosis

Authors: Campbell, Ross; Docherty, Marie-Helena; Ferenbach, David A.; Mylonas, Katie J.

DOI: https://doi.org/10.3389/fimmu.2021.700790

Paper

Repurposing BCL-2 and Jak 1/2 inhibitors: Cure and treatment of HIV-1 and other viral infections

Reece, Monica D.; Song, Colin; Hancock, Sarah et al. · 2022

Full title: Repurposing BCL-2 and Jak 1/2 inhibitors: Cure and treatment of HIV-1 and other viral infections

Authors: Reece, Monica D.; Song, Colin; Hancock, Sarah; Ribeiro, Susan Pereira; Kulpa, Deanna A.; Gavegnano, Christina

DOI: https://doi.org/10.3389/fimmu.2022.1033672

Paper

Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis

Mooney, Erin C.; Holden, Sara E.; Xia, Xia‐Juan et al. · 2021

Full title: Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis

Authors: Mooney, Erin C.; Holden, Sara E.; Xia, Xia‐Juan; Li, Yajie; Jiang, Min; Banson, Camille N.; Zhu, Bin; Sahingur, Sinem E.

DOI: https://doi.org/10.3389/fimmu.2021.774273

Paper

The role of the CD8+ T cell compartment in ageing and neurodegenerative disorders

Terrabuio, Eleonora; Zenaro, Elena; Constantin, Gabriela · 2023

Full title: The role of the CD8+ T cell compartment in ageing and neurodegenerative disorders

Authors: Terrabuio, Eleonora; Zenaro, Elena; Constantin, Gabriela

DOI: https://doi.org/10.3389/fimmu.2023.1233870

Paper

Senescent Tumor Cells in the Peritoneal Carcinomatosis Drive Immunosenescence in the Tumor Microenvironment.

Braumüller, Heidi; Mauerer, Bernhard; Berlin, Christopher et al. · 2022

Full title: Senescent Tumor Cells in the Peritoneal Carcinomatosis Drive Immunosenescence in the Tumor Microenvironment.

DOI: https://doi.org/10.3389/fimmu.2022.908449

Paper

Targeting senescent microglia in progressive multiple sclerosis: a geroscience-informed approach

Jeffrey Atkinson; Amy Dokiburra; Hayley Groover et al. · 2025

Full title: Targeting senescent microglia in progressive multiple sclerosis: a geroscience-informed approach

Authors: Jeffrey Atkinson; Amy Dokiburra; Hayley Groover; Jonathan P. Godbout; B. Segal; Yinan Zhang

DOI: https://doi.org/10.3389/fimmu.2025.1681724

Paper

Fisetin reduces the senescent tubular epithelial cell burden and also inhibits proliferative fibroblasts in murine lupus nephritis.

Ijima, Shogo; Saito, Yuki; Nagaoka, Kentaro et al. · 2022

Full title: Fisetin reduces the senescent tubular epithelial cell burden and also inhibits proliferative fibroblasts in murine lupus nephritis.

Authors: Ijima, Shogo; Saito, Yuki; Nagaoka, Kentaro; Yamamoto, Sena; Sato, Tsukasa; Miura, Norihiro; Iwamoto, Taiki; Miyajima, Maki; Chikenji, Takako S

DOI: https://doi.org/10.3389/fimmu.2022.960601

Paper

Senescent endothelial cells: key commanders of the cellular communication network within atherosclerotic plaques.

Xie, Fujia; Xi, Cheng; Bao, Guoqing et al. · 2026

Full title: Senescent endothelial cells: key commanders of the cellular communication network within atherosclerotic plaques.

Authors: Xie, Fujia; Xi, Cheng; Bao, Guoqing; Yang, Bin; Zheng, Xiaoyu; Fu, Bowen; Zheng, Zhibin

DOI: https://doi.org/10.3389/fimmu.2026.1712974

Paper

Immunosenescence and inflammaging in Parkinson’s disease: mechanisms and therapeutic prospects

Ruyu Yan; Hongfang Feng; Jie Zhang · 2026

Full title: Immunosenescence and inflammaging in Parkinson’s disease: mechanisms and therapeutic prospects

Authors: Ruyu Yan; Hongfang Feng; Jie Zhang

DOI: https://doi.org/10.3389/fimmu.2026.1749278

Paper

A new perspective on prostate cancer treatment: the interplay between cellular senescence and treatment resistance

Xu, Mengyao; Xia, Zhi-Yu; Sun, Jian‐Xuan et al. · 2024

Full title: A new perspective on prostate cancer treatment: the interplay between cellular senescence and treatment resistance

Authors: Xu, Mengyao; Xia, Zhi-Yu; Sun, Jian‐Xuan; Liu, Chen‐Qian; An, Ye; Xu, Jin‐Zhou; Zhang, Si-Han; Zhong, Xing‐Yu; Zeng, Na; Ma, Si‐Yang; He, Hao‐Dong; Wang, Shaogang; Xia, Qi‐Dong

DOI: https://doi.org/10.3389/fimmu.2024.1395047

Paper

Identification and validation of aging-related genes in heart failure based on multiple machine learning algorithms

Yu, Yiding; Wang, Lin; Hou, Wangjun et al. · 2024

Full title: Identification and validation of aging-related genes in heart failure based on multiple machine learning algorithms

Authors: Yu, Yiding; Wang, Lin; Hou, Wangjun; Xue, Yitao; Liu, Xiujuan; Li, Yan

DOI: https://doi.org/10.3389/fimmu.2024.1367235

Paper

Astrocyte Senescence and Alzheimer's Disease: A Review.

Han, Xiaojuan; Zhang, Tianying; Liu, Huanhuan et al. · 2020

Full title: Astrocyte Senescence and Alzheimer's Disease: A Review.

Authors: Han, Xiaojuan; Zhang, Tianying; Liu, Huanhuan; Mi, Yajing; Gou, Xingchun

DOI: https://doi.org/10.3389/fnagi.2020.00148

Paper

Targeting cellular senescence in senile osteoporosis: therapeutic potential of traditional Chinese medicine

Zhang, Yingyi; Yu, Xinfeng; Zhou, Chengcong et al. · 2023

Full title: Targeting cellular senescence in senile osteoporosis: therapeutic potential of traditional Chinese medicine

Authors: Zhang, Yingyi; Yu, Xinfeng; Zhou, Chengcong; Fu, Keqi; Luo, Huan; Wu, Chengliang

DOI: https://doi.org/10.3389/fmed.2023.1288993

Paper

Senolytic therapy reduces inflammation in epithelial cells from COPD patients and in smoke-exposure mice

Jonathan Baker; Leah Daly; S. Hassibi et al. · 2025

Full title: Senolytic therapy reduces inflammation in epithelial cells from COPD patients and in smoke-exposure mice

Authors: Jonathan Baker; Leah Daly; S. Hassibi; Genki Kimura; Y. Nishimoto; Y. Kizawa; Kazuhiro Ito

DOI: https://doi.org/10.3389/fmed.2025.1451056

Paper

Failure of senolytic treatment to prevent cognitive decline in a female rodent model of aging.

Rani, Asha; Bean, Linda; Budamagunta, Vivekananda et al. · 2024

Full title: Failure of senolytic treatment to prevent cognitive decline in a female rodent model of aging.

Authors: Rani, Asha; Bean, Linda; Budamagunta, Vivekananda; Kumar, Ashok; Foster, Thomas C

DOI: https://doi.org/10.3389/fnagi.2024.1384554

Paper

A comprehensive overview of cellular senescence from 1990 to 2021: A machine learning-based bibliometric analysis

Li, Chan; Liu, Zhaoya; Shi, Ruizheng · 2023

Full title: A comprehensive overview of cellular senescence from 1990 to 2021: A machine learning-based bibliometric analysis

Authors: Li, Chan; Liu, Zhaoya; Shi, Ruizheng

DOI: https://doi.org/10.3389/fmed.2023.1072359

Paper

Senescence as an Amyloid Cascade: The Amyloid Senescence Hypothesis

C. C. Walton; David V. Begelman; Wynnie Nguyen et al. · 2020

Full title: Senescence as an Amyloid Cascade: The Amyloid Senescence Hypothesis

Authors: C. C. Walton; David V. Begelman; Wynnie Nguyen; J. Andersen

DOI: https://doi.org/10.3389/fncel.2020.00129

Paper

Aging, Cellular Senescence, and Progressive Multiple Sclerosis

Papadopoulos, Dimitrios; Magliozzi, Roberta; Mitsikostas, Dimos D. et al. · 2020

Full title: Aging, Cellular Senescence, and Progressive Multiple Sclerosis

Authors: Papadopoulos, Dimitrios; Magliozzi, Roberta; Mitsikostas, Dimos D.; Gorgoulis, Vassilis G.; Nicholas, Richard

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Full title: Endothelial Senescence and Chronic Fatigue Syndrome, a COVID-19 Based Hypothesis

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Full title: Neurons and glial cells acquire a senescent signature after repeated mild traumatic brain injury in a sex-dependent manner.

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Chen, Fengrong; Sun, Jiaxue; Chen, Cheng et al. · 2022

Full title: Quercetin Mitigates Methamphetamine-Induced Anxiety-Like Behavior Through Ameliorating Mitochondrial Dysfunction and Neuroinflammation

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Wang, Jing; Lu, Yujiao; Carr, Christopher et al. · 2023

Full title: Senolytic therapy is neuroprotective and improves functional outcome long-term after traumatic brain injury in mice.

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Full title: Editorial: Role of acquired brain injury in brain-aging: new insight and evidence

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Full title: The possible therapeutic role of curcumin and quercetin in the early-stage of COVID-19—Results from a pragmatic randomized clinical trial

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Full title: Nutritional senolytics and senomorphics: Implications to immune cells metabolism and aging – from theory to practice

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Gupta, Kshama; Burns, Terry C. · 2018

Full title: Radiation-Induced Alterations in the Recurrent Glioblastoma Microenvironment: Therapeutic Implications

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Quercetin improves lacrimal gland function through its anti-oxidant actions: Evidence from animal studies, and a pilot study in healthy human volunteers

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Full title: Quercetin improves lacrimal gland function through its anti-oxidant actions: Evidence from animal studies, and a pilot study in healthy human volunteers

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Full title: Exosomal miR-9-5p derived from iPSC-MSCs ameliorates doxorubicin-induced cardiomyopathy by inhibiting cardiomyocyte senescence

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Full title: A novel senotherapeutic strategy with azithromycin for preventing endometriosis progression.

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Full title: The interplay between obesity, immunosenescence, and insulin resistance

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Full title: Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling

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Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration.

Lee, Keng Siang; Lin, Shuxiao; Copland, David A et al. · 2021

Full title: Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration.

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The diseased kidney: aging and senescent immunology

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Full title: The diseased kidney: aging and senescent immunology

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Jae Ho Kim; S. Brown; M. Gordon · 2023

Full title: Radiation-induced senescence: therapeutic opportunities

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Peripheral immune system in aging and Alzheimer’s disease

Cao, Wei; Zheng, Hui · 2018

Full title: Peripheral immune system in aging and Alzheimer’s disease

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Senolytics To slOw Progression of Sepsis (STOP-Sepsis) in elderly patients: Study protocol for a multicenter, randomized, adaptive allocation clinical trial.

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Full title: Senolytics To slOw Progression of Sepsis (STOP-Sepsis) in elderly patients: Study protocol for a multicenter, randomized, adaptive allocation clinical trial.

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He, Yonghan; Koch, Raphael; Budamagunta, Vivekananda et al. · 2020

Full title: DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas

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Structural basis of the anti-ageing effects of polyphenolics: mitigation of oxidative stress

Rolt, Adam; Cox, Lynne S. · 2020

Full title: Structural basis of the anti-ageing effects of polyphenolics: mitigation of oxidative stress

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SenPred: a single-cell RNA sequencing-based machine learning pipeline to classify deeply senescent dermal fibroblast cells for the detection of an in vivo senescent cell burden

Hughes, Bethany K.; Davis, Andrew; Milligan, Deborah et al. · 2025

Full title: SenPred: a single-cell RNA sequencing-based machine learning pipeline to classify deeply senescent dermal fibroblast cells for the detection of an in vivo senescent cell burden

Authors: Hughes, Bethany K.; Davis, Andrew; Milligan, Deborah; Wallis, Ryan; Mossa, Federica; Philpott, Michael P.; Wainwright, Linda; Gunn, David A.; Bishop, Cleo L.

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KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations

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Full title: KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations

Authors: Kaiqing Wang; Zhicheng Gong; Yanyan Chen; Meimei Zhang; Suzeng Wang; Surui Yao; Zhihui Liu; Zhaohui Huang; Bo-jian Fei

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Eliminating senescent chondrogenic progenitor cells enhances chondrogenesis under intermittent hydrostatic pressure for the treatment of OA

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Full title: Eliminating senescent chondrogenic progenitor cells enhances chondrogenesis under intermittent hydrostatic pressure for the treatment of OA

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Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis

Véret, Damien; Téjédor, Gautier; Carbajo, Esther Pérez et al. · 2025

Full title: Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis

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Clearance of senescent cells with ABT-263 improves biological functions of synovial mesenchymal stem cells from osteoarthritis patients

Yugo Miura; Kentaro Endo; Keiichiro Komori et al. · 2022

Full title: Clearance of senescent cells with ABT-263 improves biological functions of synovial mesenchymal stem cells from osteoarthritis patients

Authors: Yugo Miura; Kentaro Endo; Keiichiro Komori; I. Sekiya

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Terpenes: natural compounds found in plants as potential senotherapeutics targeting senescent mesenchymal stromal cells and promoting apoptosis.

Mazzone, Valeria; Alessio, Nicola; Aprile, Domenico et al. · 2025

Full title: Terpenes: natural compounds found in plants as potential senotherapeutics targeting senescent mesenchymal stromal cells and promoting apoptosis.

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Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia.

Suvakov, Sonja; Cubro, Hajrunisa; White, Wendy M et al. · 2019

Full title: Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia.

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Senescent bone marrow mesenchymal stem cells exacerbate subchondral bone sclerosis and osteoarthritis via the senescence-associated secretory phenotype.

Yang, Dinglong; Xu, Xin; Xu, Ke et al. · 2025

Full title: Senescent bone marrow mesenchymal stem cells exacerbate subchondral bone sclerosis and osteoarthritis via the senescence-associated secretory phenotype.

Authors: Yang, Dinglong; Xu, Xin; Xu, Ke; Yang, Mingyi; Hao, Yangquan; Aihaiti, Yirixiati; Li, Erliang; Yan, Yuheng; Lu, Chao; Xu, Peng

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Single-cell and spatial sequencing identifies senescent and germinal tumor cells in adamantinomatous craniopharyngiomas.

Wang, Xianlong; Lin, Jincheng; Liu, Hongxing et al. · 2024

Full title: Single-cell and spatial sequencing identifies senescent and germinal tumor cells in adamantinomatous craniopharyngiomas.

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The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities

Sun, Yu; Wang, Xia; Liu, Tianwei et al. · 2022

Full title: The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities

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Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells

Thanakorn Pungsrinont; Malika Franziska Sutter; Maren C. C. M. Ertingshausen et al. · 2020

Full title: Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells

Authors: Thanakorn Pungsrinont; Malika Franziska Sutter; Maren C. C. M. Ertingshausen; G. Lakshmana; Miriam Kokal; Amir Saeed Khan; A. Baniahmad

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Activation of senescence in critically ill patients: mechanisms, consequences and therapeutic opportunities.

Martín-Vicente, Paula; López-Martínez, Cecilia; Rioseras, Beatriz et al. · 2024

Full title: Activation of senescence in critically ill patients: mechanisms, consequences and therapeutic opportunities.

Authors: Martín-Vicente, Paula; López-Martínez, Cecilia; Rioseras, Beatriz; Albaiceta, Guillermo M

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Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature

Shangkun Zhao; Zhi Qiao; R. Pfeifer et al. · 2024

Full title: Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature

Authors: Shangkun Zhao; Zhi Qiao; R. Pfeifer; Hans-Christoph Pape; Keya Mao; Hai Tang; Bin Meng; Songfeng Chen; Hongjian Liu

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Cellular senescence as a key contributor to secondary neurodegeneration in traumatic brain injury and stroke

Huang, Zhihai; Xu, Peisheng; Hess, David C. et al. · 2024

Full title: Cellular senescence as a key contributor to secondary neurodegeneration in traumatic brain injury and stroke

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Enhancing adipose tissue functionality in obesity: senotherapeutics, autophagy and cellular senescence as a target.

Arias, Consuelo; Álvarez-Indo, Javiera; Cifuentes, Mariana et al. · 2024

Full title: Enhancing adipose tissue functionality in obesity: senotherapeutics, autophagy and cellular senescence as a target.

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Protocol for a pilot clinical trial of the senolytic drug combination Dasatinib Plus Quercetin to mitigate age-related health and cognitive decline in mental disorders.

Schweiger, Abigail; Diniz, Breno; Nicol, Ginger et al. · 2024

Full title: Protocol for a pilot clinical trial of the senolytic drug combination Dasatinib Plus Quercetin to mitigate age-related health and cognitive decline in mental disorders.

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Senescence and tumor suppression

Hinds, Philip W.; Pietruska, Jodie · 2017

Full title: Senescence and tumor suppression

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Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells

Wünnemann, Florian; Tadjo, Thierry Fotsing; Beaudoin, Mélissa et al. · 2023

Full title: Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells

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Modeling treatment of osteoarthritis with standard therapy and senolytic drugs

Nourridine Siewe; Avner Friedman · 2025

Full title: Modeling treatment of osteoarthritis with standard therapy and senolytic drugs

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Full title: Cell senescence, the senescence-associated secretory phenotype, and cancers

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Identification of gingerenone A as a novel senolytic compound

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Full title: Identification of gingerenone A as a novel senolytic compound

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Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis

Korfei, Martina; Stelmaszek, D; MacKenzie, BreAnne et al. · 2018

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Senescence in Aging, Within the Brain and Other Diseases: Mechanisms and Interventions

Chakrabarti, Swarup K.; Chattopadhyay, Dhrubajyoti · 2023

Full title: Senescence in Aging, Within the Brain and Other Diseases: Mechanisms and Interventions

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Emerging Anti-Aging Strategies - Scientific Basis and Efficacy.

Shetty, Ashok K; Kodali, Maheedhar; Upadhya, Raghavendra et al. · 2018

Full title: Emerging Anti-Aging Strategies - Scientific Basis and Efficacy.

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Senotherapeutic-like effect of Silybum marianum flower extract revealed on human skin cells.

Woo, Jieun; Shin, Seoungwoo; Cho, Eunae et al. · 2021

Full title: Senotherapeutic-like effect of Silybum marianum flower extract revealed on human skin cells.

Authors: Woo, Jieun; Shin, Seoungwoo; Cho, Eunae; Ryu, Dehun; Garandeau, David; Chajra, Hanane; Fréchet, Mathilde; Park, Deokhoon; Jung, Eunsun

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Senolytic Activity of Selected NRF2-Interacting Natural Compounds

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Full title: Senolytic Activity of Selected NRF2-Interacting Natural Compounds

Authors: Rahagir Salekeen; A. Ashraf; A. Habib

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Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation

Xu, Zhifang; Feng, Wei; Shen, Qian et al. · 2017

Full title: Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation

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Microbially-Induced Exosomes from Dendritic Cells Promote Paracrine Immune Senescence: Novel Mechanism of Bone Degenerative Disease in Mice.

Elsayed, Ranya; Elashiry, Mahmoud; Liu, Yutao et al. · 2023

Full title: Microbially-Induced Exosomes from Dendritic Cells Promote Paracrine Immune Senescence: Novel Mechanism of Bone Degenerative Disease in Mice.

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Macrophage-derived KIF13B interacts with USP9X to attenuate abdominal aortic aneurysm development by potentiating TFEB stability

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Full title: Macrophage-derived KIF13B interacts with USP9X to attenuate abdominal aortic aneurysm development by potentiating TFEB stability

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Kamali, Amir; Ziadlou, Reihane; Lang, Gernot et al. · 2020

Full title: Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions

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Cellular senescence exacerbates features of aging in the eyes.

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Full title: Cellular senescence exacerbates features of aging in the eyes.

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An Account of Immune Senescence in the Clinical Pathophysiology of COVID-19 Infection in Aging

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Full title: An Account of Immune Senescence in the Clinical Pathophysiology of COVID-19 Infection in Aging

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Full title: Clearance of Stress-Induced Premature Senescent Cells Alleviates the Formation of Abdominal Aortic Aneurysms

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Xiao, Xuechun; Jiang, Huimin; Wei, Huimin et al. · 2023

Full title: Endothelial Senescence in Neurological Diseases

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Full title: Type 2 Diabetes Mellitus: A Metabolic Model of Accelerated Aging - Multi-Organ Mechanisms and Intervention Approaches

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Full title: Aging, Cellular Senescence, and Glaucoma

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Full title: Revolutionizing Diabetic Foot Ulcer Care: The Senotherapeutic Approach

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Full title: Targeting Ferroptosis to Eliminate Senescent Cells: Mechanisms and Therapeutic Potential.

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Full title: Mitochondrial Imbalance in Down Syndrome: A Driver of Accelerated Brain Aging?

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Senescent adipocytes and type 2 diabetes – current knowledge and perspective concepts

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Full title: Senescent adipocytes and type 2 diabetes – current knowledge and perspective concepts

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Anderson, Rhys; Lagnado, Anthony; Maggiorani, Damien et al. · 2019

Full title: Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.

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New Perspectives on Gastric Inflammaging: Integrating Multi-Omics Mechanisms and Gerotherapeutic Strategies in Chronic Gastritis.

Wang, Li; Chen, Qiuye; Zhang, Houyan et al. · 2025

Full title: New Perspectives on Gastric Inflammaging: Integrating Multi-Omics Mechanisms and Gerotherapeutic Strategies in Chronic Gastritis.

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Epigenetic Dysregulation and Osteocyte Senescence: Convergent Drivers of Osteosarcopenia in Aging Bone and Muscle.

Nusrat, Shahneela; Din, Rahman Ud; Tariq, Muhammad Akram et al. · 2025

Full title: Epigenetic Dysregulation and Osteocyte Senescence: Convergent Drivers of Osteosarcopenia in Aging Bone and Muscle.

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Senescent cells as a target for anti-aging interventions: From senolytics to immune therapies

Tianlu Esther Fu; Zhongjun Zhou · 2025

Full title: Senescent cells as a target for anti-aging interventions: From senolytics to immune therapies

Authors: Tianlu Esther Fu; Zhongjun Zhou

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Aging and cancer hallmarks as therapeutic targets

Wang, Jingchao; Wei, Jonathan; Inuzuka, Hiroyuki · 2023

Full title: Aging and cancer hallmarks as therapeutic targets

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Cellular senescence and nanoparticle-based therapies: Current developments and perspectives

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Full title: Cellular senescence and nanoparticle-based therapies: Current developments and perspectives

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Targeting senescent cells in translational medicine.

Pàez‐Ribes, Marta; González‐Gualda, Estela; Doherty, Gary J. et al. · 2019

Full title: Targeting senescent cells in translational medicine.

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Evaluation of the Effects of Quercetin and Dihydroquercetin on Cellular Behavior and Biomarkers of Senescence in Mesenchymal Stem/Stromal Cells Obtained from Elderly Patients

E. Novoseletskaya; Anna Klementeva; Danila Fedotov et al. · 2025

Full title: Evaluation of the Effects of Quercetin and Dihydroquercetin on Cellular Behavior and Biomarkers of Senescence in Mesenchymal Stem/Stromal Cells Obtained from Elderly Patients

Authors: E. Novoseletskaya; Anna Klementeva; Danila Fedotov; Natalya Alexandrushkina; N. Basalova; O. Grigorieva; M. Vigovskiy; Ibragim Daudov; Iana Orlova; A. Efimenko

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Chronic Inflammation and Aging in Rheumatic Diseases.

Wu, Zewen; Li, Jingxuan; Li, Rong et al. · 2026

Full title: Chronic Inflammation and Aging in Rheumatic Diseases.

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New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Yi; Doornebal, Ewald J.; Pirtskhalava, Tamar et al. · 2017

Full title: New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

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What is new in the treatment of interstitial lungdiseases

Sotiropoulou, Vasilina; Karampitsakos, Thodoris; Katsaras, Matthaios et al. · 2023

Full title: What is new in the treatment of interstitial lungdiseases

Authors: Sotiropoulou, Vasilina; Karampitsakos, Thodoris; Katsaras, Matthaios; Παπαϊωάννου, Ουρανία; Tsiri, Panagiota; Sampsonas, Fotios; Tzouvelekis, Argyrios

DOI: https://doi.org/10.18332/pne/161867

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FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.

Zhang, Chi; Xie, Yun; Chen, Haicheng et al. · 2020

Full title: FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.

Authors: Zhang, Chi; Xie, Yun; Chen, Haicheng; Lv, Linyan; Yao, Jiahui; Zhang, Min; Xia, Kai; Feng, Xin; Li, Yanqing; Liang, Xiaoyan; Sun, Xiangzhou; Deng, Chunhua; Liu, Guihua

DOI: https://doi.org/10.18632/aging.102682

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The curcumin analog EF24 is a novel senolytic agent.

Li, Wen; He, Yonghan; Zhang, Rongping et al. · 2019

Full title: The curcumin analog EF24 is a novel senolytic agent.

Authors: Li, Wen; He, Yonghan; Zhang, Rongping; Zheng, Guangrong; Zhou, Daohong

DOI: https://doi.org/10.18632/aging.101787

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Targeting senescent cells: approaches, opportunities, challenges

C. von Kobbe · 2019

Full title: Targeting senescent cells: approaches, opportunities, challenges

Authors: C. von Kobbe

DOI: https://doi.org/10.18632/aging.102557

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Paradoxes of senolytics

M. Blagosklonny · 2018

Full title: Paradoxes of senolytics

Authors: M. Blagosklonny

DOI: https://doi.org/10.18632/aging.101750

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Acid ceramidase promotes senescent cell survival

Munk, Rachel; Anerillas, Carlos; Rossi, Martina et al. · 2021

Full title: Acid ceramidase promotes senescent cell survival

DOI: https://doi.org/10.18632/aging.203170

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Lifestyle vs. pharmacological interventions for healthy aging

R. Furrer; Christoph Handschin · 2020

Full title: Lifestyle vs. pharmacological interventions for healthy aging

Authors: R. Furrer; Christoph Handschin

DOI: https://doi.org/10.18632/aging.102741

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COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?

Camillo Sargiacomo; F. Sotgia; M. Lisanti · 2020

Full title: COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?

Authors: Camillo Sargiacomo; F. Sotgia; M. Lisanti

DOI: https://doi.org/10.18632/aging.103001

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Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis

Hao Yang; Cheng Chen; Hao Chen et al. · 2020

Full title: Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis

Authors: Hao Yang; Cheng Chen; Hao Chen; Xiaojun Duan; Juan Li; Yi Zhou; W. Zeng; Liu Yang

DOI: https://doi.org/10.18632/aging.103177

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The Ercc1-/Δ mouse model of accelerated senescence and aging for identification and testing of novel senotherapeutic interventions.

Wong, Alec; Kieu, Tra; Robbins, Paul D · 2020

Full title: The Ercc1-/Δ mouse model of accelerated senescence and aging for identification and testing of novel senotherapeutic interventions.

Authors: Wong, Alec; Kieu, Tra; Robbins, Paul D

DOI: https://doi.org/10.18632/aging.202321

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Metformin and SARS-CoV-2: mechanistic lessons on air pollution to weather the cytokine/thrombotic storm in COVID-19

Menéndez, Javier A. · 2020

Full title: Metformin and SARS-CoV-2: mechanistic lessons on air pollution to weather the cytokine/thrombotic storm in COVID-19

Authors: Menéndez, Javier A.

DOI: https://doi.org/10.18632/aging.103347

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Microdose lithium reduces cellular senescence in human astrocytes - a potential pharmacotherapy for COVID-19?

T. Viel; S. Chinta; Anand Rane et al. · 2020

Full title: Microdose lithium reduces cellular senescence in human astrocytes - a potential pharmacotherapy for COVID-19?

Authors: T. Viel; S. Chinta; Anand Rane; Manish Chamoli; H. Buck; J. Andersen

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SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

Utkarsh Tripathi; R. Nchioua; L. Prata et al. · 2021

Full title: SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

DOI: https://doi.org/10.18632/aging.203560

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Senescence-associated tumor growth is promoted by 12-Lipoxygenase

Shilpa Patil; Jessica L. Reedy; B. Scroggins et al. · 2022

Full title: Senescence-associated tumor growth is promoted by 12-Lipoxygenase

Authors: Shilpa Patil; Jessica L. Reedy; B. Scroggins; Ayla O. White; S. Kwon; U. Shankavaram; Alfonso López-Coral; E. Chung; D. Citrin

DOI: https://doi.org/10.18632/aging.203890

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Enhanced co-culture and enrichment of human natural killer cells for the selective clearance of senescent cells

Kim, Kristie; Admasu, Tesfahun Dessale; Stolzing, Alexandra et al. · 2022

Full title: Enhanced co-culture and enrichment of human natural killer cells for the selective clearance of senescent cells

Authors: Kim, Kristie; Admasu, Tesfahun Dessale; Stolzing, Alexandra; Sharma, Amit

DOI: https://doi.org/10.18632/aging.203931

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The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial

Hachmo, Yafit; Hadanny, Amir; Mendelovic, Sonia et al. · 2021

Full title: The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial

DOI: https://doi.org/10.18632/aging.203701

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Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial.

Hachmo, Yafit; Hadanny, Amir; Abu Hamed, Ramzia et al. · 2020

Full title: Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial.

DOI: https://doi.org/10.18632/aging.202188

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Exploring aging interventions in human brain organoids

Julio Aguado; E. Wolvetang · 2022

Full title: Exploring aging interventions in human brain organoids

Authors: Julio Aguado; E. Wolvetang

DOI: https://doi.org/10.18632/aging.203925

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Aryl hydrocarbon receptor blocks aging-induced senescence in the liver and fibroblast cells.

Nacarino-Palma, Ana; Rico-Leo, Eva M; Campisi, Judith et al. · 2022

Full title: Aryl hydrocarbon receptor blocks aging-induced senescence in the liver and fibroblast cells.

Paper

Targeting proteostasis maintenance and autophagy in senescence

Valentin L'Hôte; C. Mann; J. Thuret · 2022

Full title: Targeting proteostasis maintenance and autophagy in senescence

Authors: Valentin L'Hôte; C. Mann; J. Thuret

DOI: https://doi.org/10.18632/aging.203941

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Elucidating the anti-aging mechanism of Si Jun Zi Tang by integrating network pharmacology and experimental validation in vivo

Yuan, Yang; Zhang, Yanghuan; Zheng, Runzi et al. · 2022

Full title: Elucidating the anti-aging mechanism of Si Jun Zi Tang by integrating network pharmacology and experimental validation in vivo

Authors: Yuan, Yang; Zhang, Yanghuan; Zheng, Runzi; Yuan, Hongjun; Zhou, Ruoyu; Jia, Shuting; Liu, Jing

DOI: https://doi.org/10.18632/aging.204055

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Moderate-vigorous physical activity attenuates premature senescence of immune cells in sedentary adults with obesity: a pilot randomized controlled trial

Xiang-Ke Chen; Chen Zheng; S. Wong et al. · 2022

Full title: Moderate-vigorous physical activity attenuates premature senescence of immune cells in sedentary adults with obesity: a pilot randomized controlled trial

Authors: Xiang-Ke Chen; Chen Zheng; S. Wong; A. Ma

DOI: https://doi.org/10.18632/aging.204458

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Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic.

Al-Mansour, Fares; Alraddadi, Abdullah; He, Buwei et al. · 2023

Full title: Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic.

Authors: Al-Mansour, Fares; Alraddadi, Abdullah; He, Buwei; Saleh, Anes; Poblocka, Marta; Alzahrani, Wael; Cowley, Shaun; Macip, Salvador

DOI: https://doi.org/10.18632/aging.204616

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Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle

Lei Liu; Xianlin Yue; Zewei Sun et al. · 2022

Full title: Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle

Authors: Lei Liu; Xianlin Yue; Zewei Sun; W. S. Hambright; Q. Feng; Yan Cui; J. Huard; P. Robbins; Zhihui Wang; Xiaodong Mu

DOI: https://doi.org/10.18632/aging.204275

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Meeting Report: Aging Research and Drug Discovery

Meron, Esther; Thaysen, Maria; Angeli, Suzanne et al. · 2022

Full title: Meeting Report: Aging Research and Drug Discovery

DOI: https://doi.org/10.18632/aging.203859

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Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells.

Rysanek, David; Vasicova, Pavla; Kolla, Jayaprakash Narayana et al. · 2022

Full title: Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells.

Authors: Rysanek, David; Vasicova, Pavla; Kolla, Jayaprakash Narayana; Sedlak, David; Andera, Ladislav; Bartek, Jiri; Hodny, Zdenek

DOI: https://doi.org/10.18632/aging.204207

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Glutaminase inhibitors rejuvenate human skin via clearance of senescent cells: a study using a mouse/human chimeric model

Takaya, Kento; Ishii, Tatsuyuki; Asou, Toru et al. · 2022

Full title: Glutaminase inhibitors rejuvenate human skin via clearance of senescent cells: a study using a mouse/human chimeric model

Authors: Takaya, Kento; Ishii, Tatsuyuki; Asou, Toru; Kishi, Kazuo

DOI: https://doi.org/10.18632/aging.204391

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In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

Parinya Samakkarnthai; D. Saul; Lei Zhang et al. · 2023

Full title: In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

DOI: https://doi.org/10.18632/aging.204701

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Development of a DNA damage-induced senescence model in osteoarthritic chondrocytes

Georget, Mélina; Defois, A.; Guiho, Romain et al. · 2023

Full title: Development of a DNA damage-induced senescence model in osteoarthritic chondrocytes

DOI: https://doi.org/10.18632/aging.204881

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3-Deazaadenosine keeps senescence at bay

Ana Guerrero; Jesús Gil · 2023

Full title: 3-Deazaadenosine keeps senescence at bay

Authors: Ana Guerrero; Jesús Gil

DOI: https://doi.org/10.18632/aging.204625

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A chronic wound model to investigate skin cellular senescence.

Wyles, Saranya P; Dashti, Parisa; Pirtskhalava, Tamar et al. · 2023

Full title: A chronic wound model to investigate skin cellular senescence.

DOI: https://doi.org/10.18632/aging.204667

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Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema

Alberta Palazzo; Gabriela Makulyte; Delphine Goerhig et al. · 2023

Full title: Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema

Authors: Alberta Palazzo; Gabriela Makulyte; Delphine Goerhig; Jean‐Jacques Médard; Vincent Gros; François Trottein; Serge Adnot; D. Vindrieux; J. Flaman; David Bernard

DOI: https://doi.org/10.18632/aging.205259

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Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions

Lee, Edwin; Carreras-Gallo, Natàlia; Lopez, Leilani et al. · 2024

Full title: Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions

DOI: https://doi.org/10.18632/aging.205581

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Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells

Joseph S. Spina; Tracy L. Carr; Lucy A. Phillips et al. · 2024

Full title: Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells

DOI: https://doi.org/10.18632/aging.205994

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Senolytic agent ABT-263 mitigates low- and high-LET radiation-induced gastrointestinal cancer development in Apc1638N/+ mice

Kamendra Kumar; Bo-Hyun Moon; Santosh Kumar et al. · 2025

Full title: Senolytic agent ABT-263 mitigates low- and high-LET radiation-induced gastrointestinal cancer development in Apc1638N/+ mice

Authors: Kamendra Kumar; Bo-Hyun Moon; Santosh Kumar; Jerry Angdisen; Bhaskar V S Kallakury; A. Fornace; S. Suman

DOI: https://doi.org/10.18632/aging.206183

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Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1

Christelle Morris; Sébastien Durand; P. Jalinot · 2021

Full title: Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1

Authors: Christelle Morris; Sébastien Durand; P. Jalinot

DOI: https://doi.org/10.18632/oncotarget.27923

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Anti-aging: senolytics or gerostatics (unconventional view)

Blagosklonny, Mikhail V. · 2021

Full title: Anti-aging: senolytics or gerostatics (unconventional view)

Authors: Blagosklonny, Mikhail V.

DOI: https://doi.org/10.18632/oncotarget.28049

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Senescence-driven pathogenesis in chronic lung diseases: from mechanistic insights to translational approaches

Shaofei Liu; Si-Chang Fan; Rui-Qi Wang et al. · 2026

Full title: Senescence-driven pathogenesis in chronic lung diseases: from mechanistic insights to translational approaches

Authors: Shaofei Liu; Si-Chang Fan; Rui-Qi Wang; Xiang-Jin Wang; Tian-Yang Lu; Jing-Wen Song; Yong-Jian Zhu; Zhifu Guo; Ni Zhu; Ping Yuan

DOI: https://doi.org/10.20517/2574-1209.2025.115

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Senescent cell accumulation is associated with T-cell imbalance in the skin.

Matveeva, K S; Kolmykov, S K; Sokolova, T S et al. · 2025

Full title: Senescent cell accumulation is associated with T-cell imbalance in the skin.

Authors: Matveeva, K S; Kolmykov, S K; Sokolova, T S; Salimov, D R; Shevyrev, D V

DOI: https://doi.org/10.18699/vjgb-25-118

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Senolytic vaccination: a new mandate for cardiovascular health?

Lear, Travis; Finkel, Toren · 2022

Full title: Senolytic vaccination: a new mandate for cardiovascular health?

Authors: Lear, Travis; Finkel, Toren

DOI: https://doi.org/10.20517/jca.2022.03

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The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases

Salminen, Antero · 2024

Full title: The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases

Authors: Salminen, Antero

DOI: https://doi.org/10.1007/s00109-024-02444-6

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Senescence-associated β-galactosidase in subcutaneous adipose tissue associates with altered glycaemic status and truncal fat in severe obesity.

Rouault, Christine; Marcelin, Geneviève; Adriouch, Solia et al. · 2021

Full title: Senescence-associated β-galactosidase in subcutaneous adipose tissue associates with altered glycaemic status and truncal fat in severe obesity.

DOI: https://doi.org/10.1007/s00125-020-05307-0

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Senescence under appraisal: hopes and challenges revisited

Davan-Wetton, Camilla S. A.; Pessolano, Emanuela; Perretti, Mauro et al. · 2021

Full title: Senescence under appraisal: hopes and challenges revisited

Authors: Davan-Wetton, Camilla S. A.; Pessolano, Emanuela; Perretti, Mauro; Montero‐Melendez, Trinidad

DOI: https://doi.org/10.1007/s00018-020-03746-x

Paper

Cellular senescence: at the nexus between ageing and diabetes

Allyson K. Palmer; B. Gustafson; J. Kirkland et al. · 2019

Full title: Cellular senescence: at the nexus between ageing and diabetes

Authors: Allyson K. Palmer; B. Gustafson; J. Kirkland; U. Smith

DOI: https://doi.org/10.1007/s00125-019-4934-x

Paper

Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard.

Rothmiller, Simone; Jäger, Niklas; Meier, Nicole et al. · 2021

Full title: Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard.

DOI: https://doi.org/10.1007/s00204-020-02946-5

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Apoptosis resistance of senescent cells is an intrinsic barrier for senolysis induced by cardiac glycosides.

Deryabin, Pavel I; Shatrova, Alla N; Borodkina, Aleksandra V · 2021

Full title: Apoptosis resistance of senescent cells is an intrinsic barrier for senolysis induced by cardiac glycosides.

Authors: Deryabin, Pavel I; Shatrova, Alla N; Borodkina, Aleksandra V

DOI: https://doi.org/10.1007/s00018-021-03980-x

Paper

Cellular senescence in the tumor with a bone niche microenvironment: friend or foe?

Alavimanesh, Sajad; Nayerain Jazi, Negar; Choubani, Maedeh et al. · 2025

Full title: Cellular senescence in the tumor with a bone niche microenvironment: friend or foe?

Authors: Alavimanesh, Sajad; Nayerain Jazi, Negar; Choubani, Maedeh; Saeidi, Farzane; Afkhami, Hamed; Yarahmadi, Aref; Ronaghi, Hossein; Khani, Pouria; Modarressi, Mohammad Hossein

DOI: https://doi.org/10.1007/s10238-025-01564-8

Paper

Nano-encapsulated senolytic cocktail attenuates germ cell senescence in female mice.

Guan, Yiting; Deng, Shuyue; Zou, Xiaopeng et al. · 2025

Full title: Nano-encapsulated senolytic cocktail attenuates germ cell senescence in female mice.

Authors: Guan, Yiting; Deng, Shuyue; Zou, Xiaopeng; Wei, Wenlu; Li, Zechen; Zhong, Jiajing; Zhu, Yanmei; Zhang, Donghui; Ju, Yanmin; Sun, Qing-Yuan; Zhang, Hongyong

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Repurposed FDA-approved drugs targeting genes influencing aging can extend lifespan and healthspan in rotifers

Snell, Terry W.; Johnston, Rachel; Matthews, Amelia B. et al. · 2018

Full title: Repurposed FDA-approved drugs targeting genes influencing aging can extend lifespan and healthspan in rotifers

Authors: Snell, Terry W.; Johnston, Rachel; Matthews, Amelia B.; Zhou, Hongyi; Gao, Mu; Skolnick, Jeffrey

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Paper

Vascular senescence and aging: mechanisms, clinical implications, and therapeutic prospects.

Picos, Aitor; Seoane, Nuria; Campos-Toimil, Manuel et al. · 2025

Full title: Vascular senescence and aging: mechanisms, clinical implications, and therapeutic prospects.

Authors: Picos, Aitor; Seoane, Nuria; Campos-Toimil, Manuel; Viña, Dolores

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Paper

Cellular Senescence Contributes to Colonic Barrier Integrity Impairment Induced by Toxoplasma gondii Infection

Yingting Huang; Yumeng Zhou; Zhicheng He et al. · 2025

Full title: Cellular Senescence Contributes to Colonic Barrier Integrity Impairment Induced by Toxoplasma gondii Infection

Authors: Yingting Huang; Yumeng Zhou; Zhicheng He; Jiayi Yang; Jianqi Gu; Bingqian Cui; Siyu Li; Heng Deng; Wendi Zhao; Xiaoying Yang; Fenfen Sun; Cheng He; Wei Pan

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Therapeutic Potential of Senolytics in Cardiovascular Disease

Emily Dookun; J. Passos; H. Arthur et al. · 2020

Full title: Therapeutic Potential of Senolytics in Cardiovascular Disease

Authors: Emily Dookun; J. Passos; H. Arthur; G. Richardson

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Paper

Hypoxia-inducible factor and cellular senescence in pulmonary aging and disease.

Thapa, Riya; Marianesan, Arockia Babu; Rekha, A et al. · 2025

Full title: Hypoxia-inducible factor and cellular senescence in pulmonary aging and disease.

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Senolytic Treatment Attenuates Global Ischemic Brain Injury and Enhances Cognitive Recovery by Targeting Mitochondria

Caihong Gu; Ting Guo; Xiaobing Chen et al. · 2025

Full title: Senolytic Treatment Attenuates Global Ischemic Brain Injury and Enhances Cognitive Recovery by Targeting Mitochondria

Authors: Caihong Gu; Ting Guo; Xiaobing Chen; Xinyu Zhou; Yong Sun

DOI: https://doi.org/10.1007/s10571-025-01580-y

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Using the drug-protein interactome to identify anti-ageing compounds for humans

Fuentealba, Matías; Dönertaş, Handan Melike; Williams, Rhianna et al. · 2018

Full title: Using the drug-protein interactome to identify anti-ageing compounds for humans

Authors: Fuentealba, Matías; Dönertaş, Handan Melike; Williams, Rhianna; Labbadia, Johnathan; Thornton, Janet M.; Partridge, Linda

DOI: https://doi.org/10.1101/438234

Paper

Senotherapeutic potential against xeroderma pigmentosum

Xuebing Wang; Masako Nishida; A. Yoshioka et al. · 2025

Full title: Senotherapeutic potential against xeroderma pigmentosum

Authors: Xuebing Wang; Masako Nishida; A. Yoshioka; C. Y. Chung; Shinya Hashimoto; Hideki Tanizawa; Shinya Ohta; Ken-ichi Noma; Takashi Fukumoto

DOI: https://doi.org/10.1101/2025.05.22.655641

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Beyond Static Pipes: Mechanisms and In Vitro Models of Vascular Aging

Hetzer, Martin W.; Bersini, Simone · 2022

Full title: Beyond Static Pipes: Mechanisms and In Vitro Models of Vascular Aging

Authors: Hetzer, Martin W.; Bersini, Simone

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Senescence and the SASP: many therapeutic avenues

J. Birch; J. Gil · 2020

Full title: Senescence and the SASP: many therapeutic avenues

Authors: J. Birch; J. Gil

DOI: https://doi.org/10.1101/gad.343129.120

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Molecular Mechanisms of Cellular Senescence and Immuno-Senescence: Insights from Model Organisms and Emerging Pathways

Alebachew Molla · 2025

Full title: Molecular Mechanisms of Cellular Senescence and Immuno-Senescence: Insights from Model Organisms and Emerging Pathways

Authors: Alebachew Molla

DOI: https://doi.org/10.11648/j.ajbls.20251305.12

Paper

Mitochondrial dysfunction in cell senescence and aging

Miwa, Satomi; Kashyap, Sonu; Chini, Eduardo N. et al. · 2022

Full title: Mitochondrial dysfunction in cell senescence and aging

Authors: Miwa, Satomi; Kashyap, Sonu; Chini, Eduardo N.; Zglinicki, Thomas von

DOI: https://doi.org/10.1172/jci158447

Paper

IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis.

Faust, Heather J; Zhang, Hong; Han, Jin et al. · 2020

Full title: IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis.

DOI: https://doi.org/10.1172/JCI134091

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Aged murine bone marrow myeloid and mesenchymal cells develop unique senescence phenotypes.

Madison L. Doolittle; Mitchell N. Froemming; Jennifer L. Rowsey et al. · 2026

Full title: Aged murine bone marrow myeloid and mesenchymal cells develop unique senescence phenotypes.

Authors: Madison L. Doolittle; Mitchell N. Froemming; Jennifer L. Rowsey; Ming Ruan; Leena Sapra; J. Farr; David G Monroe; Sundeep Khosla

DOI: https://doi.org/10.1172/jci195772

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Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice.

Liu, Jiatong; Zhang, Jun; Lin, Xi et al. · 2022

Full title: Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice.

Authors: Liu, Jiatong; Zhang, Jun; Lin, Xi; Boyce, Brendan F; Zhang, Hengwei; Xing, Lianping

DOI: https://doi.org/10.1172/JCI148073

Paper

Cellular senescence: a key therapeutic target in aging and diseases

Lei Zhang; Louise E. Pitcher; Matthew J. Yousefzadeh et al. · 2022

Full title: Cellular senescence: a key therapeutic target in aging and diseases

Authors: Lei Zhang; Louise E. Pitcher; Matthew J. Yousefzadeh; L. Niedernhofer; P. Robbins; Yi Zhu

DOI: https://doi.org/10.1172/jci158450

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Mixing old and young: enhancing rejuvenation and accelerating aging

Lau, Ashley; Kennedy, Brian K.; Kirkland, James L. et al. · 2019

Full title: Mixing old and young: enhancing rejuvenation and accelerating aging

Authors: Lau, Ashley; Kennedy, Brian K.; Kirkland, James L.; Tullius, Stefan G.

DOI: https://doi.org/10.1172/jci123946

Paper

JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice

Rivellini, Cristina; Porrello, Emanuela; Dina, Giorgia et al. · 2021

Full title: JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice

DOI: https://doi.org/10.1172/jci145071

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Mechanisms and functions of cellular senescence.

Herranz, Nicolás; Gil, Jesús · 2018

Full title: Mechanisms and functions of cellular senescence.

Authors: Herranz, Nicolás; Gil, Jesús

DOI: https://doi.org/10.1172/JCI95148

Paper

Senescent cells and osteoarthritis: a painful connection

Jeon, Ok Hee; David, Nathaniel E.; Campisi, Judith et al. · 2018

Full title: Senescent cells and osteoarthritis: a painful connection

Authors: Jeon, Ok Hee; David, Nathaniel E.; Campisi, Judith; Elisseeff, Jennifer H.

DOI: https://doi.org/10.1172/jci95147

Paper

An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis.

Lee, Jin Young; Reyes, Nabora S; Ravishankar, Supriya et al. · 2024

Full title: An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis.

DOI: https://doi.org/10.1172/JCI173371

Paper

Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

O’Sullivan, Eoin; Mylonas, Katie J.; Bell, Rachel et al. · 2022

Full title: Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

DOI: https://doi.org/10.20944/preprints202207.0160.v1

Paper

Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.

Ok-hee Jeon; David R. Wilson; Cristina C. Clement et al. · 2019

Full title: Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.

Authors: Ok-hee Jeon; David R. Wilson; Cristina C. Clement; Sona Rathod; Chris C. Cherry; B. Powell; Z. Lee; A. Khalil; J. Green; J. Campisi; L. Santambrogio; K. Witwer; J. Elisseeff

DOI: https://doi.org/10.1172/jci.insight.125019

Paper

A single-cell mass cytometry platform to map the effects of preclinical drugs on cartilage homeostasis

Sahu, Neety; Grandi, Fiorella C.; Bhutani, Nidhi · 2022

Full title: A single-cell mass cytometry platform to map the effects of preclinical drugs on cartilage homeostasis

Authors: Sahu, Neety; Grandi, Fiorella C.; Bhutani, Nidhi

DOI: https://doi.org/10.1172/jci.insight.160702

Paper

Senescence plays a role in myotonic dystrophy type 1.

García-Puga, Mikel; Saenz-Antoñanzas, Ander; Gerenu, Gorka et al. · 2022

Full title: Senescence plays a role in myotonic dystrophy type 1.

DOI: https://doi.org/10.1172/jci.insight.159357

Paper

Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia

Englund, Davis A.; Jolliffe, Alyssa M.; Hanson, Gabriel J. et al. · 2023

Full title: Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia

DOI: https://doi.org/10.1172/jci.insight.169512

Paper

Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2

N. Cheng; Ki-Hyun Kim; L. Lau · 2022

Full title: Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2

Authors: N. Cheng; Ki-Hyun Kim; L. Lau

DOI: https://doi.org/10.1172/jci.insight.158207

Paper

All-trans retinoic acid inhibits glioblastoma progression and attenuates radiation-induced brain injury

Minggang Fu; Yiling Zhang; Bi Peng et al. · 2024

Full title: All-trans retinoic acid inhibits glioblastoma progression and attenuates radiation-induced brain injury

Authors: Minggang Fu; Yiling Zhang; Bi Peng; Na Luo; Yuanyuan Zhang; Wenjun Zhu; Fen Yang; Ziqi Chen; Qiang Zhang; Qianxia Li; Xin Chen; Yuanhui Liu; Guoxian Long; Guangyuan Hu; Xiaohong Peng

DOI: https://doi.org/10.1172/jci.insight.179530

Paper

Cytotoxic and senescence-inducing effects of BLU554 in pancreatic ductal adenocarcinoma: an in vitro study

Masakazu Fujiwara; Seiichi Shinji; Yuuki Shichi et al. · 2025

Full title: Cytotoxic and senescence-inducing effects of BLU554 in pancreatic ductal adenocarcinoma: an in vitro study

Authors: Masakazu Fujiwara; Seiichi Shinji; Yuuki Shichi; K. Nonaka; Yasuko Hasegawa; Kimimasa Takahashi; Hirofumi Rokutan; Tomio Arai; Toshiyuki Ishiwata

DOI: https://doi.org/10.1186/s12885-025-15317-z

Paper

Dietary intervention reverses molecular markers of hepatocellular senescence in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH

Flensted-Jensen, Mathias; Oró, Denise; Rørbeck, Emma A. et al. · 2024

Full title: Dietary intervention reverses molecular markers of hepatocellular senescence in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH

Authors: Flensted-Jensen, Mathias; Oró, Denise; Rørbeck, Emma A.; Zhang, Chen; Madsen, Martin Rønn; Madsen, Andreas Nygaard; Norlin, Jenny; Feigh, Michael; Larsen, Steen; Hansen, Henrik H.

DOI: https://doi.org/10.1186/s12876-024-03141-x

Paper

Geroprotector drugs and exercise: friends or foes on healthy longevity?

Elliehausen, Christian J.; Anderson, Rozalyn M.; Diffee, Gary M. et al. · 2023

Full title: Geroprotector drugs and exercise: friends or foes on healthy longevity?

Authors: Elliehausen, Christian J.; Anderson, Rozalyn M.; Diffee, Gary M.; Rhoads, Timothy W.; Lamming, Dudley W.; Hornberger, Troy A.; Konopka, Adam R.

DOI: https://doi.org/10.1186/s12915-023-01779-9

Paper

Lycium barbarum polysaccharides in ageing and its potential use for prevention and treatment of osteoarthritis: a systematic review

Junguo Ni; M. Au; H. Kong et al. · 2021

Full title: Lycium barbarum polysaccharides in ageing and its potential use for prevention and treatment of osteoarthritis: a systematic review

Authors: Junguo Ni; M. Au; H. Kong; Xinluan Wang; C. Wen

DOI: https://doi.org/10.1186/s12906-021-03385-0

Paper

Cellular senescence and SASP in tumor progression and therapeutic opportunities.

Dong, Zening; Luo, Yahan; Yuan, Zhangchen et al. · 2024

Full title: Cellular senescence and SASP in tumor progression and therapeutic opportunities.

Authors: Dong, Zening; Luo, Yahan; Yuan, Zhangchen; Tian, Yu; Jin, Tianqiang; Xu, Feng

DOI: https://doi.org/10.1186/s12943-024-02096-7

Paper

Hemin enhances the cardioprotective effects of mesenchymal stem cell-derived exosomes against infarction via amelioration of cardiomyocyte senescence

Zheng, Huifeng; Liang, Xiaoting; Han, Qian et al. · 2021

Full title: Hemin enhances the cardioprotective effects of mesenchymal stem cell-derived exosomes against infarction via amelioration of cardiomyocyte senescence

DOI: https://doi.org/10.1186/s12951-021-01077-y

Paper

Extracellular vesicles from ovarian cancer cells induce senescent lipid-laden macrophages to facilitate omental metastasis.

Li, Guoqing; Zhou, Xiaoling; Li, Wenhan et al. · 2025

Full title: Extracellular vesicles from ovarian cancer cells induce senescent lipid-laden macrophages to facilitate omental metastasis.

Authors: Li, Guoqing; Zhou, Xiaoling; Li, Wenhan; Wu, Qiulei; Liu, Tong; Huang, Lin; Liu, Xiaoli; Zhao, Jing; Xu, Xiaohan; Xu, Linjuan; Wang, Zehua; Gong, Lanqing; Cai, Liqiong; Cai, Jing

DOI: https://doi.org/10.1186/s12951-025-03612-7

Paper

Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases

Zhou, Huakang; Khan, Dilaware; Hussain, Sajid Muhammad et al. · 2023

Full title: Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases

Authors: Zhou, Huakang; Khan, Dilaware; Hussain, Sajid Muhammad; Gerdes, Norbert; Hagenbeck, Carsten; Rana, Majeed; Cornelius, Jan F.; Muhammad, Sajjad

DOI: https://doi.org/10.1186/s12950-023-00366-7

Paper

Ectopic and visceral fat deposition in aging, obesity, and idiopathic pulmonary fibrosis: an interconnected role

Cheng, Xiaoyun; Jiang, Shuhan; Pan, Boyu et al. · 2023

Full title: Ectopic and visceral fat deposition in aging, obesity, and idiopathic pulmonary fibrosis: an interconnected role

Authors: Cheng, Xiaoyun; Jiang, Shuhan; Pan, Boyu; Xie, Wei; Meng, Jie

DOI: https://doi.org/10.1186/s12944-023-01964-3

Paper

Quercetin enhances decidualization through AKT-ERK-p53 signaling and supports a role for senescence in endometriosis.

Delenko, Julia; Xue, Xiangying; Chatterjee, Prodyot K et al. · 2024

Full title: Quercetin enhances decidualization through AKT-ERK-p53 signaling and supports a role for senescence in endometriosis.

Authors: Delenko, Julia; Xue, Xiangying; Chatterjee, Prodyot K; Hyman, Nathaniel; Shih, Andrew J; Adelson, Robert P; Safaric Tepes, Polona; Gregersen, Peter K; Metz, Christine N

DOI: https://doi.org/10.1186/s12958-024-01265-z

Paper

Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin

Marco Raffaele; Kristína Kovačovicová; Jan Frohlich et al. · 2021

Full title: Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin

Authors: Marco Raffaele; Kristína Kovačovicová; Jan Frohlich; Oriana Lo Re; S. Giallongo; J. Oben; M. Faldyna; L. Levá; A. Giannone; D. Cabibi; M. Vinciguerra

DOI: https://doi.org/10.1186/s12964-021-00731-0

Paper

Targeting cellular senescence in kidney diseases and aging: A focus on mesenchymal stem cells and their paracrine factors

Seyyedeh Mina Hejazian; Seyyed Sina Hejazian; Seyyedeh Mina Mostafavi et al. · 2024

Full title: Targeting cellular senescence in kidney diseases and aging: A focus on mesenchymal stem cells and their paracrine factors

Authors: Seyyedeh Mina Hejazian; Seyyed Sina Hejazian; Seyyedeh Mina Mostafavi; Seyed Mahdi Hosseiniyan; S. Montazersaheb; M. Ardalan; S. Zununi Vahed; Abolfazl Barzegari

DOI: https://doi.org/10.1186/s12964-024-01968-1

Paper

Inhibition of the FEN1-PBX1 axis elicits cellular senescence in breast cancer via the increased intracellular reactive oxygen species levels.

Wu, Min; Wu, Benmeng; Huang, Xiaoshan et al. · 2025

Full title: Inhibition of the FEN1-PBX1 axis elicits cellular senescence in breast cancer via the increased intracellular reactive oxygen species levels.

Authors: Wu, Min; Wu, Benmeng; Huang, Xiaoshan; Wang, Zirui; Zhu, Miaolin; Zhu, Yaqin; Yu, Lin; Liu, Jingjing

DOI: https://doi.org/10.1186/s12967-025-06216-9

Paper

Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study

Krishnakumar, I. M.; Jaja-Chimedza, Asha; Joseph, Ashil et al. · 2022

Authors: Krishnakumar, I. M.; Jaja-Chimedza, Asha; Joseph, Ashil; Balakrishnan, Abhilash; Maliakel, Balu; Swick, Andrew G.

DOI: https://doi.org/10.1017/jns.2022.72

Paper

68722 Role of ER calcium in beta cell senescence and diabetes pathophysiology

Staci A. Weaver; T. Kono; Farooq Syed et al. · 2021

Full title: 68722 Role of ER calcium in beta cell senescence and diabetes pathophysiology

Authors: Staci A. Weaver; T. Kono; Farooq Syed; R. Bone; C. Evans-Molina

DOI: https://doi.org/10.1017/cts.2021.446

Paper

Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions

Yongsik Cho; Sumin Jeong; Hyeon-Seop Kim et al. · 2021

Full title: Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions

Authors: Yongsik Cho; Sumin Jeong; Hyeon-Seop Kim; Donghyun Kang; Jeeyeon Lee; Seung-Baik Kang; Jin-Hong Kim

DOI: https://doi.org/10.1038/s12276-021-00710-y

Paper

Cellular senescence mediates fibrotic pulmonary disease

Schafer, Marissa J.; White, Thomas A.; Iijima, Koji et al. · 2017

Full title: Cellular senescence mediates fibrotic pulmonary disease

DOI: https://doi.org/10.1038/ncomms14532

Paper

Cellular senescence drives age-dependent hepatic steatosis

Ogrodnik, Mikołaj; Miwa, Satomi; Tchkonia, Tamar et al. · 2017

Full title: Cellular senescence drives age-dependent hepatic steatosis

DOI: https://doi.org/10.1038/ncomms15691

Paper

Lysosomal trapping of palbociclib and its functional implications.

Llanos, Susana; Megias, Diego; Blanco-Aparicio, Carmen et al. · 2019

Full title: Lysosomal trapping of palbociclib and its functional implications.

Authors: Llanos, Susana; Megias, Diego; Blanco-Aparicio, Carmen; Hernández-Encinas, Elena; Rovira, Miguel; Pietrocola, Federico; Serrano, Manuel

DOI: https://doi.org/10.1038/s41388-019-0695-8

Paper

SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence.

Lee, Sang Hyup; Yang, Ji-Hye; Park, Ui-Hyun et al. · 2023

Full title: SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence.

Authors: Lee, Sang Hyup; Yang, Ji-Hye; Park, Ui-Hyun; Choi, Hanbyeul; Kim, Yoo Sung; Yoon, Bo-Eun; Han, Hye-Jeong; Kim, Hyun-Taek; Um, Soo-Jong; Kim, Eun-Joo

DOI: https://doi.org/10.1038/s12276-023-01012-1

Paper

MEOX1: a novel druggable target that orchestrates the activation of fibroblasts in cardiac fibrosis

David Schumacher; Fabian Peisker; R. Kramann · 2021

Full title: MEOX1: a novel druggable target that orchestrates the activation of fibroblasts in cardiac fibrosis

Authors: David Schumacher; Fabian Peisker; R. Kramann

DOI: https://doi.org/10.1038/s41392-021-00842-7

Paper

Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema.

Park, Jung-Jin; Oh, Kwangseok; Lee, Gun-Wu et al. · 2023

Full title: Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema.

Authors: Park, Jung-Jin; Oh, Kwangseok; Lee, Gun-Wu; Bang, Geul; Park, Jin-Hee; Kim, Han-Byeol; Kim, Jin Young; Shin, Eun-Young; Kim, Eung-Gook

DOI: https://doi.org/10.1038/s12276-023-00966-6

Paper

BET family protein degraders poised to join the senolytic arsenal

Zufeng Guo; Hanjing Peng; Yongmei Xie · 2020

Full title: BET family protein degraders poised to join the senolytic arsenal

Authors: Zufeng Guo; Hanjing Peng; Yongmei Xie

DOI: https://doi.org/10.1038/s41392-020-0202-2

Paper

Step further towards targeted senolytic therapy: therapeutic potential of uPAR-CAR T cells for senescence-related diseases

Yujia Huang; Tao Liu · 2020

Full title: Step further towards targeted senolytic therapy: therapeutic potential of uPAR-CAR T cells for senescence-related diseases

Authors: Yujia Huang; Tao Liu

DOI: https://doi.org/10.1038/s41392-020-00268-7

Paper

Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma models.

Sigaud, Romain; Stefanski, Anja; Selt, Florian et al. · 2025

Full title: Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma models.

DOI: https://doi.org/10.1038/s41392-025-02279-8

Paper

Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults

Diniz, Breno S.; Reynolds, Charles F.; Sibille, Etienne et al. · 2019

Full title: Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults

Authors: Diniz, Breno S.; Reynolds, Charles F.; Sibille, Etienne; Bot, Mariska; Penninx, Brenda W.J.H.

DOI: https://doi.org/10.1038/s41398-019-0541-3

Paper

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

Hubáčková, Soňa; Davidová, Eliška; Rohlenová, Kateřina et al. · 2018

Full title: Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

DOI: https://doi.org/10.1038/s41418-018-0118-3

Paper

Paracrine roles of cellular senescence in promoting tumourigenesis.

Gonzalez-Meljem, Jose Mario; Apps, John Richard; Fraser, Helen Christina et al. · 2018

Full title: Paracrine roles of cellular senescence in promoting tumourigenesis.

Authors: Gonzalez-Meljem, Jose Mario; Apps, John Richard; Fraser, Helen Christina; Martinez-Barbera, Juan Pedro

DOI: https://doi.org/10.1038/s41416-018-0066-1

Paper

Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair.

Li, Chengjun; Qin, Tian; Zhao, Jinyun et al. · 2024

Full title: Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair.

Authors: Li, Chengjun; Qin, Tian; Zhao, Jinyun; Jin, Yuxin; Qin, Yiming; He, Rundong; Wu, Tianding; Duan, Chunyue; Jiang, Liyuan; Yuan, Feifei; Lu, Hongbin; Cao, Yong; Hu, Jianzhong

DOI: https://doi.org/10.1038/s41413-024-00323-x

Paper

Combining adoptive NK cell infusion with a dopamine-releasing peptide reduces senescent cells in aged mice

Zongke Bai; Peiwei Yang; F. Yu et al. · 2022

Full title: Combining adoptive NK cell infusion with a dopamine-releasing peptide reduces senescent cells in aged mice

Authors: Zongke Bai; Peiwei Yang; F. Yu; Zhong Li; Zheng Yao; Jean Martinez; Mengwei Li; Hanmei Xu

DOI: https://doi.org/10.1038/s41419-022-04562-w

Paper

Induction of senescence-associated secretory phenotype underlies the therapeutic efficacy of PRC2 inhibition in cancer

Chu, Liping; Qu, Yu-Xiu; An, Yang et al. · 2022

Full title: Induction of senescence-associated secretory phenotype underlies the therapeutic efficacy of PRC2 inhibition in cancer

Authors: Chu, Liping; Qu, Yu-Xiu; An, Yang; Hou, Linjun; Li, Juewan; Li, Weijia; Fan, Gaofeng; Song, Bao‐Liang; Li, En; Zhang, Liye; Qi, Wei

DOI: https://doi.org/10.1038/s41419-022-04601-6

Paper

Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides

Trayssac, Magali; Clarke, Christopher J.; Stith, Jeffrey L. et al. · 2021

Full title: Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides

Authors: Trayssac, Magali; Clarke, Christopher J.; Stith, Jeffrey L.; Snider, Justin M.; Newen, Naomi; Gault, Christopher; Hannun, Yusuf A.; Obeid, Lina M.

DOI: https://doi.org/10.1038/s41419-020-03281-4

Paper

Early senescence and production of senescence-associated cytokines are major determinants of radioresistance in head-and-neck squamous cell carcinoma

Schoetz, Ulrike; Klein, Diana; Heß, Julia et al. · 2021

Full title: Early senescence and production of senescence-associated cytokines are major determinants of radioresistance in head-and-neck squamous cell carcinoma

DOI: https://doi.org/10.1038/s41419-021-04454-5

Paper

Sequential targeting of YAP1 and p21 enhances the elimination of senescent cells induced by the BET inhibitor JQ1

Zhang, Huan‐Tian; Gui, Tao; Liu, Rixu et al. · 2021

Full title: Sequential targeting of YAP1 and p21 enhances the elimination of senescent cells induced by the BET inhibitor JQ1

DOI: https://doi.org/10.1038/s41419-021-03416-1

Paper

Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma

Hu, Qinchao; Peng, Jianmin; Jiang, Laibo et al. · 2020

Full title: Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma

Authors: Hu, Qinchao; Peng, Jianmin; Jiang, Laibo; Li, Wuguo; Su, Qiao; Zhang, Jiayu; Li, Huan; Song, Ming; Cheng, Bin; Xia, Juan; Wu, Tong

DOI: https://doi.org/10.1038/s41419-020-03126-0

Paper

Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche.

Peng, Xiaohong; Wu, Yi; Brouwer, Uilke et al. · 2020

Full title: Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche.

Authors: Peng, Xiaohong; Wu, Yi; Brouwer, Uilke; van Vliet, Thijmen; Wang, Boshi; Demaria, Marco; Barazzuol, Lara; Coppes, Rob P

DOI: https://doi.org/10.1038/s41419-020-03074-9

Paper

p16-mediated G0/G1 cell cycle arrest leads to SASP and fibrosis in Fuchs endothelial corneal dystrophy

Mohit Parekh; Yadav Adhikari; Neha Deshpande et al. · 2026

Full title: p16-mediated G0/G1 cell cycle arrest leads to SASP and fibrosis in Fuchs endothelial corneal dystrophy

Authors: Mohit Parekh; Yadav Adhikari; Neha Deshpande; R. Wong; M. Price; Francis W. Price; Ula V. Jurkunas

DOI: https://doi.org/10.1038/s41419-026-08425-6

Paper

Targeting CK2 eliminates senescent cells and prolongs lifespan in Zmpste24-deficient mice.

Zhang, Jie; Sun, Pengfei; Wu, Zhuping et al. · 2024

Full title: Targeting CK2 eliminates senescent cells and prolongs lifespan in Zmpste24-deficient mice.

Authors: Zhang, Jie; Sun, Pengfei; Wu, Zhuping; Wu, Jie; Jia, Jiali; Zou, Haoman; Mo, Yanzhen; Zhou, Zhongjun; Liu, Baohua; Ao, Ying; Wang, Zimei

DOI: https://doi.org/10.1038/s41419-024-06760-0

Paper

Nintedanib induces senolytic effect via STAT3 inhibition.

Cho, Hyun-Ji; Hwang, Jeong-A; Yang, Eun Jae et al. · 2022

Full title: Nintedanib induces senolytic effect via STAT3 inhibition.

Authors: Cho, Hyun-Ji; Hwang, Jeong-A; Yang, Eun Jae; Kim, Eok-Cheon; Kim, Jae-Ryong; Kim, Sung Young; Kim, Young Zoon; Park, Sang Chul; Lee, Young-Sam

DOI: https://doi.org/10.1038/s41419-022-05207-8

Paper

Ionizing irradiation-induced Fgr in senescent cells mediates fibrosis

Mukherjee, Amitava; Epperly, Michael W.; Shields, Donna et al. · 2021

Full title: Ionizing irradiation-induced Fgr in senescent cells mediates fibrosis

DOI: https://doi.org/10.1038/s41420-021-00741-4

Paper

Cellular senescence in ischemia/reperfusion injury

Chen, Chaojin; Zheng, Muxu; Hou, Hongbiao et al. · 2022

Full title: Cellular senescence in ischemia/reperfusion injury

Authors: Chen, Chaojin; Zheng, Muxu; Hou, Hongbiao; Fang, Sijian; Chen, Liubing; Yang, Jing; Yao, Weifeng; Zhang, Qi; Hei, Ziqing

DOI: https://doi.org/10.1038/s41420-022-01205-z

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Inhibition of MCL-1 to eliminate senescent cells and mitigate renal fibrosis in aristolochic acid nephropathy.

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- **Authors:** Madonna, Rosalinda - **Year:** 2022 - **Journal:** The Journal of Cardiovascular Aging - **Source:** openalex

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Full title: The Possible Role of Β-Cell Senescence in the Development of Type 2 Diabetes Mellitus

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Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration

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Full title: Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development.

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Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer

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Full title: Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer

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The BET inhibitor/degrader ARV-825 prolongs the growth arrest response to Fulvestrant + Palbociclib and suppresses proliferative recovery in ER-positive breast cancer

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Full title: The Dual Role of Cellular Senescence in Macrophages: Unveiling the Hidden Driver of Age-Related Inflammation in Kidney Disease

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Full title: Complexity of Inflammation in the Trajectory of Vascular Disease: Interleukin 6 and Beyond

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Full title: Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review)

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Full title: Targeting senescent cells and tumor therapy (Review)

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Full title: Mechanism and significance of cell senescence induced by viral infection

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Full title: Senescent hepatic stellate cells drive inflammation and disease progression in MASH (Review).

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Full title: Alternative splicing of BCL‑X and implications for treating hematological malignancies (Review)

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Full title: Cellular senescence in cancer: Unveiling dual roles, tumor microenvironment dynamics and therapeutic innovations (Review).

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Full title: Epigenetic Signatures of Aging: A Comprehensive Study of Biomarker Discovery

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Full title: Quercetin attenuates the symptoms of osteoarthritis in vitro and in vivo by suppressing ferroptosis via activation of AMPK/Nrf2/Gpx4 signaling

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Full title: Protective Mechanisms of Quercetin in Various Lung-induced Injuries

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Full title: Exploring a Novel Approach to Senolysis Using a Urokinase Plasminogen Activator Receptor-targeting Antibody-Drug Conjugate

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The Dual Role of Cellular Senescence in Cervical Cancer

Xinning Tong · 2025

Full title: The Dual Role of Cellular Senescence in Cervical Cancer

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INFLAMMAGING IN MUSCLE: THE MISSING LINK BETWEEN SARCOPENIA AND IDIOPATHIC INFLAMMATORY MYOPATHIES

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Full title: Interventional Strategies to Delay Aging-Related Dysfunctions of the Musculoskeletal System

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Mild Uncoupling of Mitochondria Synergistically Enhances Senolytic Specificity and Sensitivity of BH3 Mimetics

Miwa, Satomi; Fielder, Edward; Ishaq, Abbas et al. · 2024

Full title: Mild Uncoupling of Mitochondria Synergistically Enhances Senolytic Specificity and Sensitivity of BH3 Mimetics

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Damage-Induced Senescent Immune Cells Regulate Regeneration of the Zebrafish Retina

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Full title: Damage-Induced Senescent Immune Cells Regulate Regeneration of the Zebrafish Retina

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Ruckstuhl, Marco M.; Bischof, Evelyne; Blatch, Dana et al. · 2023

Full title: Translational longevity medicine: a Swiss perspective in an ageing country

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Full title: Senescence and Beyond: Exploring Senolytic Strategies for Chronic Disease

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Subtype-Specific SASP Dynamics Predict Mesenchymal Transition in Recurrent Glioblastoma

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Full title: Subtype-Specific SASP Dynamics Predict Mesenchymal Transition in Recurrent Glioblastoma

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Single Cell Transcriptomics Reveals Global Markers of Transcriptional Diversity Across Different Forms of Cellular Senescence

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Full title: Single Cell Transcriptomics Reveals Global Markers of Transcriptional Diversity Across Different Forms of Cellular Senescence

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Full title: Biology of Stress Responses in Aging

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Pharmacology of Senolytics: Targeting Cellular Aging in Chronic Diseases

Priyanka R.Chaudhari · 2025

Full title: Pharmacology of Senolytics: Targeting Cellular Aging in Chronic Diseases

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Standard treatment against paediatric BRAF-V600E glioma promotes senescence and sensitizes tumours to BCL-xL inhibition

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Full title: Standard treatment against paediatric BRAF-V600E glioma promotes senescence and sensitizes tumours to BCL-xL inhibition

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“BAP1 Loss Induces Senescence and Enhances the Response to Radiation Therapy and Senolytics”

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Full title: “BAP1 Loss Induces Senescence and Enhances the Response to Radiation Therapy and Senolytics”

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The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases

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Full title: The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases

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Senescence-Associated Secretory Phenotype (SASP) in Diabetes

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Full title: Senescence-Associated Secretory Phenotype (SASP) in Diabetes

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Dasatinib regulates the proliferation and osteogenic differentiation of PDLSCs through Erk and EID3 signals

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Full title: Dasatinib regulates the proliferation and osteogenic differentiation of PDLSCs through Erk and EID3 signals

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Full title: Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and Fibrosis via Oxidative Stress, DNA Damage, and p53/TGFβ1-Induced Epithelial-Mesenchymal Transition

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The Roles of Myeloid Cells in Aging-related Liver Diseases

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Full title: The Roles of Myeloid Cells in Aging-related Liver Diseases

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Clearance of senescent cells enhances skin wound healing in type 2 diabetic mice

P. N. Samarawickrama; Guiqin Zhang; Enfang Zhu et al. · 2024

Full title: Clearance of senescent cells enhances skin wound healing in type 2 diabetic mice

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Targeted elimination of senescent cells by engineered extracellular vesicles attenuates atherosclerosis in ApoE-/- mice with minimal side effects.

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Full title: Targeted elimination of senescent cells by engineered extracellular vesicles attenuates atherosclerosis in ApoE-/- mice with minimal side effects.

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Ability of Local Clearance of Senescent Cells in Ipsilateral Hemisphere to Mitigate Acute Ischemic Brain Injury in Mice

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Full title: Ability of Local Clearance of Senescent Cells in Ipsilateral Hemisphere to Mitigate Acute Ischemic Brain Injury in Mice

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Clearance of senescent cells during cardiac ischemia-reperfusion injury improves heart recovery following myocardial infarction

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Full title: Clearance of senescent cells during cardiac ischemia-reperfusion injury improves heart recovery following myocardial infarction

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Tsuji, Shingo; Hase, Takeshi; Yachie‐Kinoshita, Ayako et al. · 2020

Full title: Artificial intelligence based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer’s disease

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Aryl hydrocarbon receptor blocks aging-induced senescence in the liver and fibroblast cells.

Nacarino-Palma, Ana; Rico-Leo, Eva M; Campisi, Judith et al. · 2022

Full title: Aryl hydrocarbon receptor blocks aging-induced senescence in the liver and fibroblast cells.

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Full title: Therapy-induced normal tissue damage promotes breast cancer metastasis

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Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung

Nabora Reyes de Mochel; Ka Neng Cheong; Monica Cassandras et al. · 2020

Full title: Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung

Authors: Nabora Reyes de Mochel; Ka Neng Cheong; Monica Cassandras; Chaoqun Wang; M. Krasilnikov; Peri Matatia; Ari B. Molofsky; J. Campisi; Tien Peng

DOI: https://doi.org/10.1101/2020.06.10.142893

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Selective Vulnerability of Senescent Glioblastoma Cells to Bcl-XL Inhibition

Rahman, Masum; Olson, Ian; Mansour, Moustafa et al. · 2020

Full title: Selective Vulnerability of Senescent Glioblastoma Cells to Bcl-XL Inhibition

DOI: https://doi.org/10.1101/2020.06.03.132712

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Rapamycin microparticles induce autophagy, prevent senescence and are effective in treatment of Osteoarthritis

Dhanabalan, Kaamini M.; Dravid, Ameya A.; Agarwal, Smriti et al. · 2021

Full title: Rapamycin microparticles induce autophagy, prevent senescence and are effective in treatment of Osteoarthritis

Authors: Dhanabalan, Kaamini M.; Dravid, Ameya A.; Agarwal, Smriti; Sharath, Ramanath K.; Padmanabhan, Ashok Kumar; Agarwal, Rachit

DOI: https://doi.org/10.1101/2021.07.20.453073

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Modulation of fracture healing by the transient accumulation of senescent cells

D. Saul; D. Monroe; Jennifer L. Rowsey et al. · 2021

Full title: Modulation of fracture healing by the transient accumulation of senescent cells

Authors: D. Saul; D. Monroe; Jennifer L. Rowsey; R. L. Kosinsky; S. Vos; Madison L. Doolittle; J. Farr; S. Khosla

DOI: https://doi.org/10.1101/2021.05.18.444618

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Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

Rawlings, Thomas M.; Makwana, Komal; Taylor, Deborah M. et al. · 2021

Full title: Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

DOI: https://doi.org/10.1101/2021.03.02.433560

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Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

O’Sullivan, Eoin; Mylonas, Katie J.; Bell, Rachel et al. · 2022

Full title: Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

Paper

Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

Fielder, Edward; Wan, Tengfei; Alimohammadiha, Ghazaleh et al. · 2021

Full title: Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

DOI: https://doi.org/10.1101/2021.12.15.472756

Paper

Clearance of defective muscle stem cells by senolytics reduces the expression of senescence-associated secretory phenotype and restores myogenesis in myotonic dystrophy type 1

Talita C. Conte; Gilberto Duran-Bishop; Zakaria Orfi et al. · 2022

Full title: Clearance of defective muscle stem cells by senolytics reduces the expression of senescence-associated secretory phenotype and restores myogenesis in myotonic dystrophy type 1

DOI: https://doi.org/10.1101/2022.06.22.497227

Paper

Fisetin Attenuates Cellular Senescence Accumulation During Culture Expansion of Human Adipose-Derived Stem Cells.

Mullen, Michael; Nelson, Anna Laura; Goff, Alexander et al. · 2023

Full title: Fisetin Attenuates Cellular Senescence Accumulation During Culture Expansion of Human Adipose-Derived Stem Cells.

Authors: Mullen, Michael; Nelson, Anna Laura; Goff, Alexander; Billings, Jake; Kloser, Heidi; Huard, Charles; Mitchell, John; Hambright, William Sealy; Ravuri, Sudheer; Huard, Johnny

DOI: https://doi.org/10.1093/stmcls/sxad036

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Dexamethasone induces senescence of lung epithelial cells and augments TGF-β1-mediated production of the fibrosis mediator serpin E1 (plasminogen activator inhibitor-1)

Longhorne, Francesca. L.; Wilkinson, Holly N.; Hardman, Matthew J. et al. · 2021

Full title: Dexamethasone induces senescence of lung epithelial cells and augments TGF-β1-mediated production of the fibrosis mediator serpin E1 (plasminogen activator inhibitor-1)

Authors: Longhorne, Francesca. L.; Wilkinson, Holly N.; Hardman, Matthew J.; Hart, Simon P.

DOI: https://doi.org/10.1101/2021.11.29.470337

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In the pursuit of longevity: anti-aging substances, nanotechnological preparations, and emerging approaches

Giannouli, Elena; Karalis, Vangelis · 2022

Full title: In the pursuit of longevity: anti-aging substances, nanotechnological preparations, and emerging approaches

Authors: Giannouli, Elena; Karalis, Vangelis

DOI: https://doi.org/10.1101/2022.03.20.22272670

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Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

Meiners, Franziska; Hinz, Burkhard; Boeckmann, Lars et al. · 2024

Full title: Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

Authors: Meiners, Franziska; Hinz, Burkhard; Boeckmann, Lars; Secci, Riccardo; Sueto, Salem Oduro Beffi; Kuepfer, Lars; Fuellen, Georg; Barrantes, Israel

Paper

Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma

Salam, Rana; Saliou, Alexa; Bielle, Franck et al. · 2023

Full title: Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma

Paper

Cellular senescence preserves viral genome maintenance

A. M. Pham; Luz E. Ortiz; A. Lukacher et al. · 2022

Full title: Cellular senescence preserves viral genome maintenance

Authors: A. M. Pham; Luz E. Ortiz; A. Lukacher; H. Kwun

DOI: https://doi.org/10.1101/2022.07.12.499783

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Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

Madison L. Doolittle; D. Saul; J. Kaur et al. · 2023

Full title: Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

Authors: Madison L. Doolittle; D. Saul; J. Kaur; Jennifer L. Rowsey; Stephanie J. Vos; K. Pavelko; J. Farr; D. Monroe; S. Khosla

DOI: https://doi.org/10.1101/2023.01.12.523760

Paper

Therapy Induced Tumor Senescence Model

Ghanendra Singh · 2022

Full title: Therapy Induced Tumor Senescence Model

Authors: Ghanendra Singh

DOI: https://doi.org/10.1101/2022.10.23.513380

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High-dose Polyphenol-rich Nutrition Improves Lipid and Inflammation Profiles and Triggers Apoptotic Signaling in Healthy Elderly People (the ErdBEHR Study)

Hartmann, Alexander; Secci, Riccardo; Mensch, Juliane et al. · 2023

Full title: High-dose Polyphenol-rich Nutrition Improves Lipid and Inflammation Profiles and Triggers Apoptotic Signaling in Healthy Elderly People (the ErdBEHR Study)

DOI: https://doi.org/10.1101/2023.04.03.23287994

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Damage-Induced Senescent Immune Cells Regulate Regeneration of the Zebrafish Retina

Gregory J. Konar; Z. Flickinger; Shivani Sharma et al. · 2024

Full title: Damage-Induced Senescent Immune Cells Regulate Regeneration of the Zebrafish Retina

Authors: Gregory J. Konar; Z. Flickinger; Shivani Sharma; Kyle T. Vallone; Charles E. Lyon; Claire Doshier; Audrey L. Lingan; William Lyon; James G. Patton

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Quercetin, a senolytic, enhances endometrial stromal cell decidualization through AKT and p53 signaling and reveals the potential role of senescent stromal cells in endometriosis

Julia Delenko; Xiangying Xue; Prodyot K. Chatterjee et al. · 2023

Full title: Quercetin, a senolytic, enhances endometrial stromal cell decidualization through AKT and p53 signaling and reveals the potential role of senescent stromal cells in endometriosis

Authors: Julia Delenko; Xiangying Xue; Prodyot K. Chatterjee; Nathaniel Hyman; Andrew J Shih; Robert P. Adelson; Polona Safaric-Tepes; P. Gregersen; Christine N Metz

DOI: https://doi.org/10.1101/2023.08.30.23294800

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Treatment of advanced atherosclerotic mice with the senolytic agent ABT-263 is associated with reduced indices of plaque stability and increased mortality

Karnewar, Santosh; Karnewar, Vaishnavi; Shankman, Laura S. et al. · 2023

Full title: Treatment of advanced atherosclerotic mice with the senolytic agent ABT-263 is associated with reduced indices of plaque stability and increased mortality

Authors: Karnewar, Santosh; Karnewar, Vaishnavi; Shankman, Laura S.; Owens, Gary K.

DOI: https://doi.org/10.1101/2023.07.12.548696

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TRAIL pathway suppression of cancer cell growth and immune cell-mediated tumor cell-killing in a senescent fibroblast-constructed tumor microenvironment

Shengliang Zhang; K. Huntington; Lanlan Zhou et al. · 2023

Full title: TRAIL pathway suppression of cancer cell growth and immune cell-mediated tumor cell-killing in a senescent fibroblast-constructed tumor microenvironment

Authors: Shengliang Zhang; K. Huntington; Lanlan Zhou; A. Seyhan; Bianca Kun; B. Carneiro; J. Kreiling; J. M. Sedivy; Wafik S. El-Deiry

DOI: https://doi.org/10.1101/2023.11.30.569479

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Vutiglabridin Alleviates Cellular Senescence Process of Dysfunctional Replication, Metabolic Regulation, and Circadian Clock in Primary Human Dermal Fibroblasts

Heo, Jin-Woong; Lee, Hye Eun; Lee, Jimin et al. · 2023

Full title: Vutiglabridin Alleviates Cellular Senescence Process of Dysfunctional Replication, Metabolic Regulation, and Circadian Clock in Primary Human Dermal Fibroblasts

Authors: Heo, Jin-Woong; Lee, Hye Eun; Lee, Jimin; Choi, Leo Sungwong; Shin, Jaejin; Mun, Ji Young; Park, Hyung Soon; Park, Sang Chul; Nam, Chang‐Hoon

DOI: https://doi.org/10.1101/2023.02.12.528227

Paper

Colchicine inhibited oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: Implications in vascular diseases

Zhou, Huakang; Khan, Dilaware; Hussain, Sajid Muhammad et al. · 2023

Full title: Colchicine inhibited oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: Implications in vascular diseases

Authors: Zhou, Huakang; Khan, Dilaware; Hussain, Sajid Muhammad; Gerdes, Norbert; Hagenbeck, Carsten; Rana, Majeed; Cornelius, Jan F.; Muhammad, Sajjad

DOI: https://doi.org/10.1101/2023.08.04.552075

Paper

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

Julio Aguado; Alberto A. Amarilla; Atefeh Taherian Fard et al. · 2023

Full title: Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

Paper

Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness

Eskiocak, Onur; Chowdhury, Saria; Shah, Vyom et al. · 2024

Full title: Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness

Authors: Eskiocak, Onur; Chowdhury, Saria; Shah, Vyom; Nnuji-John, Emmanuella; Chung, Charlie; Boyer, Jacob A.; Harris, Alexander S.; Habel, Jill; Sadelain, Michel; Beyaz, Semir; Amor, Corina

DOI: https://doi.org/10.1101/2024.03.19.585779

Paper

Urinary Clusterin is a Biomarker of Renal Epithelial Senescence and Predicts Human Kidney Disease Progression

David P. Baird; Max Reck; Ross Campbell et al. · 2024

Full title: Urinary Clusterin is a Biomarker of Renal Epithelial Senescence and Predicts Human Kidney Disease Progression

DOI: https://doi.org/10.1101/2024.03.14.24303997

Paper

Senescence of endplate osteoclasts induces sensory innervation and spinal pain

Pan, Dayu; Benkato, Kheiria Gamal; Han, Xuequan et al. · 2023

Full title: Senescence of endplate osteoclasts induces sensory innervation and spinal pain

Authors: Pan, Dayu; Benkato, Kheiria Gamal; Han, Xuequan; Zheng, Jinjian; Kumar, Vijay; Wan, Mei; Zheng, Junying; Cao, Xu

Paper

Senolytic Intervention Improves Cognition, Metabolism, and Adiposity in Female APP NL-F/NL-F Mice

Fang, Yimin; Peck, Mackenzie R.; Quinn, Kathleen et al. · 2023

Full title: Senolytic Intervention Improves Cognition, Metabolism, and Adiposity in Female APP NL-F/NL-F Mice

Authors: Fang, Yimin; Peck, Mackenzie R.; Quinn, Kathleen; Chapman, Jenelle E.; Medina, David X.; McFadden, Samuel; Bartke, Andrzej; Hascup, Kevin N.; Hascup, Erin R.

DOI: https://doi.org/10.1101/2023.12.12.571277

Paper

CD4 T Cells Acquire Cytotoxic Properties to Modulate Cellular Senescence and Aging

Elyahu, Yehezqel; Feygin, Ilana; Pinkas, Noa et al. · 2024

Full title: CD4 T Cells Acquire Cytotoxic Properties to Modulate Cellular Senescence and Aging

DOI: https://doi.org/10.1101/2024.01.14.575313

Paper

Suppression of autophagy induces senescence in the heart.

Zhai, Peiyong; Sung, Eun-Ah; Shiheido-Watanabe, Yuka et al. · 2024

Full title: Suppression of autophagy induces senescence in the heart.

Authors: Zhai, Peiyong; Sung, Eun-Ah; Shiheido-Watanabe, Yuka; Takayama, Koichiro; Tian, Yimin; Sadoshima, Junichi

DOI: https://doi.org/10.1016/j.yjmcc.2024.08.001

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Primary oocytes with cellular senescence features are involved in ovarian aging in mice

Hao Yan; Edgar Andres Diaz Miranda; Shiying Jin et al. · 2024

Full title: Primary oocytes with cellular senescence features are involved in ovarian aging in mice

Authors: Hao Yan; Edgar Andres Diaz Miranda; Shiying Jin; Faith Wilson; Kang An; Brooke Godbee; Xiaobin Zheng; Astrid Roshealy Brau-Rodríguez; Lei Lei

Paper

Aging and injury drive neuronal senescence in the dorsal root ganglia.

Donovan, Lauren J; Brewer, Chelsie L; Bond, Sabrina F et al. · 2024

Full title: Aging and injury drive neuronal senescence in the dorsal root ganglia.

Authors: Donovan, Lauren J; Brewer, Chelsie L; Bond, Sabrina F; Lopez, Aleishai Pena; Hansen, Linus H; Jordan, Claire E; González, Oscar C; de Lecea, Luis; Kauer, Julie A; Tawfik, Vivianne L

DOI: https://doi.org/10.1101/2024.01.20.576299

Paper

Chemo-senolytic therapeutic potential against angiosarcoma

Xuebing Wang; C. Y. Chung; A. Yoshioka et al. · 2023

Full title: Chemo-senolytic therapeutic potential against angiosarcoma

Authors: Xuebing Wang; C. Y. Chung; A. Yoshioka; Shinya Hashimoto; H. Jimbo; Hideki Tanizawa; Shinya Ohta; T. Fukumoto; Ken-ichi Noma

DOI: https://doi.org/10.1101/2023.10.19.563192

Paper

IAP antagonists potentiate TNFα-triggered apoptosis but selectively eliminate senescent tumor cells independently of TNFα

Hiroaki Ochiiwa; Takeshi Wakasa; Yuki Kataoka et al. · 2025

Full title: IAP antagonists potentiate TNFα-triggered apoptosis but selectively eliminate senescent tumor cells independently of TNFα

Authors: Hiroaki Ochiiwa; Takeshi Wakasa; Yuki Kataoka; K. Ando; E. Oki; Yoshihiko Maehara; M. Iimori; Hiroyuki Kitao

DOI: https://doi.org/10.1101/2025.02.03.636172

Paper

Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy model.

Yao, Minmin; Wei, Zhiliang; Nielsen, Jonathan Scharff et al. · 2024

Full title: Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy model.

DOI: https://doi.org/10.1016/j.nbd.2024.106711

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Senolytic Treatment for Low Back Pain

M. Mannarino; Hosni Cherif; Saber Ghazizadeh et al. · 2024

Full title: Senolytic Treatment for Low Back Pain

Authors: M. Mannarino; Hosni Cherif; Saber Ghazizadeh; Oliver Wu Martinez; Kai Sheng; Elsa Cousineau; Seunghwan Lee; M. Millecamps; Chan Gao; Jean A. Ouellet; Laura S Stone; L. Haglund

DOI: https://doi.org/10.1101/2024.01.15.575738

Paper

Senolytic treatment with fisetin reverses age-related endothelial dysfunction partially mediated by SASP factor CXCL12.

Mahoney, Sophia A; Mazan-Mamczarz, Krystyna; Tsitsipatis, Dimitrios et al. · 2025

Full title: Senolytic treatment with fisetin reverses age-related endothelial dysfunction partially mediated by SASP factor CXCL12.

DOI: https://doi.org/10.1101/2025.08.13.670216

Paper

Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by promoting the release of pro-anabolic mediators

Maurer, Svenja; Kirsch, Valeria; Ruths, Leonie et al. · 2024

Full title: Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by promoting the release of pro-anabolic mediators

Authors: Maurer, Svenja; Kirsch, Valeria; Ruths, Leonie; Brenner, Rolf E.; Riegger, Jana

DOI: https://doi.org/10.1101/2024.04.04.588076

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DNAm aging biomarkers are responsive: Insights from 51 longevity interventional studies in humans

Raghav Sehgal; D. Borrus; Jessica Kasamato et al. · 2024

Full title: DNAm aging biomarkers are responsive: Insights from 51 longevity interventional studies in humans

Authors: Raghav Sehgal; D. Borrus; Jessica Kasamato; Jenel F. Armstrong; John T. González; Yaroslav Markov; Ahana Priyanka; Ryan Smith; Natàlia Carreras; Varun B. Dwaraka; A. Higgins-Chen

DOI: https://doi.org/10.1101/2024.10.22.619522

Paper

Targeted inhibition of Bcl-xL following radiation reduces tumourigenesis in preclinical models of H3K27M-altered diffuse midline glioma

Ashley Vardon; S. Haston; Romain Guiho et al. · 2024

Full title: Targeted inhibition of Bcl-xL following radiation reduces tumourigenesis in preclinical models of H3K27M-altered diffuse midline glioma

DOI: https://doi.org/10.1101/2024.12.20.629607

Paper

Eg5 Inhibitor SB743921 Causes p53-Dependent Cell Cycle Arrest, Senescence and Death in Tumor Cells

Iaroslav E. Abramenko; A. Khamidullina; T. A. Kiryukhina et al. · 2025

Full title: Eg5 Inhibitor SB743921 Causes p53-Dependent Cell Cycle Arrest, Senescence and Death in Tumor Cells

Authors: Iaroslav E. Abramenko; A. Khamidullina; T. A. Kiryukhina; A. Tvorogova; Nataliya G. Pavlenko; A. V. Bruter; V. Tatarskiy

DOI: https://doi.org/10.1101/2025.01.23.634373

Paper

Translating the Science of Aging into Therapeutic Interventions

Kirkland, James L. · 2016

Full title: Translating the Science of Aging into Therapeutic Interventions

Authors: Kirkland, James L.

DOI: https://doi.org/10.1101/cshperspect.a025908

Paper

Elimination of senescent cells with senolytic host-directed therapy reduces tuberculosis progression in mice

Somnath Shee; Yazmin B. Martinez-Martinez; Benjamin Koleske et al. · 2025

Full title: Elimination of senescent cells with senolytic host-directed therapy reduces tuberculosis progression in mice

Authors: Somnath Shee; Yazmin B. Martinez-Martinez; Benjamin Koleske; Shivraj M. Yabaji; L. Kobzik; Igor Kramnik; William R. Bishai

DOI: https://doi.org/10.1101/2025.03.28.645957

Paper

Targeting breast cancer senescence in 3D models of bone metastasis

Eleane C B Hamburger; Mansoureh Mohseni Garakani; Saleh Alfaisali et al. · 2025

Full title: Targeting breast cancer senescence in 3D models of bone metastasis

Authors: Eleane C B Hamburger; Mansoureh Mohseni Garakani; Saleh Alfaisali; Jean A. Ouellet; Michael H. Weber; Livia Garzia; Lisbet Haglund; D. Rosenzweig

DOI: https://doi.org/10.1101/2025.06.26.661856

Paper

Aged‐senescent cells contribute to impaired heart regeneration

Fiona C Lewis-McDougall; P. Ruchaya; Eva Domenjo-Vila et al. · 2018

Full title: Aged‐senescent cells contribute to impaired heart regeneration

DOI: https://doi.org/10.1111/acel.12931

Paper

Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers

Utkarsh Tripathi; Masayoshi Suda; Vagisha Kulshreshtha et al. · 2025

Full title: Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers

DOI: https://doi.org/10.1101/2025.08.27.672709

Paper

A DNA Methylation Fingerprint of Cellular Senescence

Levine, Morgan E.; Leung, Diana L.; Minteer, Christopher J. et al. · 2019

Full title: A DNA Methylation Fingerprint of Cellular Senescence

Authors: Levine, Morgan E.; Leung, Diana L.; Minteer, Christopher J.; Gonzalez, John

DOI: https://doi.org/10.1101/674580

Paper

Tau protein aggregation induces cellular senescence in the brain

N. Musi; Joseph M. Valentine; K. R. Sickora et al. · 2018

Full title: Tau protein aggregation induces cellular senescence in the brain

Authors: N. Musi; Joseph M. Valentine; K. R. Sickora; Eric Baeuerle; C. S. Thompson; Ashley Zapata; Q. Shen; Miranda E. Orr

DOI: https://doi.org/10.1101/369074

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Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice

Davidová, Eliška; Trnovská, Jaroslava; Svoboda, Petr et al. · 2022

Full title: Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice

DOI: https://doi.org/10.1038/s41467-022-29486-z

Paper

Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence.

Fleury, Hubert; Malaquin, Nicolas; Tu, Véronique et al. · 2019

Full title: Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence.

DOI: https://doi.org/10.1038/s41467-019-10460-1

Paper

Immune checkpoint inhibitors as senolytic agents

Parminderjit Singh; P. Kapahi; J. V. van Deursen · 2022

Full title: Immune checkpoint inhibitors as senolytic agents

Authors: Parminderjit Singh; P. Kapahi; J. V. van Deursen

DOI: https://doi.org/10.1038/s41422-022-00761-4

Paper

Identification of HSP90 inhibitors as a novel class of senolytics

Fuhrmann‐Stroissnigg, Heike; Ling, Yuan Yuan; Zhao, Jing et al. · 2017

Full title: Identification of HSP90 inhibitors as a novel class of senolytics

DOI: https://doi.org/10.1038/s41467-017-00314-z

Paper

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

D. Saul; R. L. Kosinsky; E. Atkinson et al. · 2021

Full title: A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

DOI: https://doi.org/10.1038/s41467-022-32552-1

Paper

Impaired immune surveillance accelerates accumulation of senescent cells and aging

Ovadya, Yossi; Landsberger, Tomer; Leins, Hanna et al. · 2018

Full title: Impaired immune surveillance accelerates accumulation of senescent cells and aging

DOI: https://doi.org/10.1038/s41467-018-07825-3

Paper

A β-galactosidase kiss of death for senescent cells

Xiaoqian Liu; J. Belmonte; Weiqi Zhang et al. · 2020

Full title: A β-galactosidase kiss of death for senescent cells

Authors: Xiaoqian Liu; J. Belmonte; Weiqi Zhang; Guang-Hui Liu

DOI: https://doi.org/10.1038/s41422-020-0325-6

Paper

Senescent cells limit p53 activity via multiple mechanisms to remain viable.

Sturmlechner, Ines; Sine, Chance C; Jeganathan, Karthik B et al. · 2022

Full title: Senescent cells limit p53 activity via multiple mechanisms to remain viable.

Authors: Sturmlechner, Ines; Sine, Chance C; Jeganathan, Karthik B; Zhang, Cheng; Fierro Velasco, Raul O; Baker, Darren J; Li, Hu; van Deursen, Jan M

DOI: https://doi.org/10.1038/s41467-022-31239-x

Paper

A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

Wakita, Masahiro; Takahashi, Akiko; Sano, Osamu et al. · 2020

Full title: A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

DOI: https://doi.org/10.1038/s41467-020-15719-6

Paper

Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice

Khan, Sajid; Kellish, Patrick; Connis, Nick et al. · 2023

Full title: Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice

DOI: https://doi.org/10.1038/s41420-022-01296-8

Paper

Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations

Wang, Yuan; Deng, Peng; Liu, Yuting et al. · 2020

Full title: Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations

DOI: https://doi.org/10.1038/s41467-020-19360-1

Paper

Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton

Madison L. Doolittle; D. Saul; J. Kaur et al. · 2023

Full title: Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton

Authors: Madison L. Doolittle; D. Saul; J. Kaur; Jennifer L. Rowsey; Stephanie J. Vos; K. Pavelko; J. Farr; D. Monroe; S. Khosla

DOI: https://doi.org/10.1038/s41467-023-40393-9

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Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer.

Troiani, Martina; Colucci, Manuel; D'Ambrosio, Mariantonietta et al. · 2022

Full title: Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer.

DOI: https://doi.org/10.1038/s41467-022-29824-1

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Challenges in developing Geroscience trials

Rolland, Yves; Sierra, Felipe; Ferrucci, Luigi et al. · 2023

Full title: Challenges in developing Geroscience trials

DOI: https://doi.org/10.1038/s41467-023-39786-7

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A BDNF-TrkB autocrine loop enhances senescent cell viability

Anerillas, Carlos; Herman, Allison B.; Munk, Rachel et al. · 2022

Full title: A BDNF-TrkB autocrine loop enhances senescent cell viability

Paper

Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma

Salam, Rana; Saliou, Alexa; Bielle, Franck et al. · 2023

Full title: Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma

Paper

Clearance of defective muscle stem cells by senolytics restores myogenesis in myotonic dystrophy type 1.

Conte, Talita C; Duran-Bishop, Gilberto; Orfi, Zakaria et al. · 2023

Full title: Clearance of defective muscle stem cells by senolytics restores myogenesis in myotonic dystrophy type 1.

DOI: https://doi.org/10.1038/s41467-023-39663-3

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Senescent-like microglia limit remyelination through the senescence associated secretory phenotype

Phillip S. Gross; Violeta Durán-Laforet; Lana T. Ho et al. · 2025

Full title: Senescent-like microglia limit remyelination through the senescence associated secretory phenotype

DOI: https://doi.org/10.1038/s41467-025-57632-w

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Discovery of senolytics using machine learning

Smer-Barreto, Vanessa; Quintanilla, Andrea; Elliott, Richard et al. · 2023

Full title: Discovery of senolytics using machine learning

DOI: https://doi.org/10.1038/s41467-023-39120-1

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Detection of senescence using machine learning algorithms based on nuclear features

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Full title: Detection of senescence using machine learning algorithms based on nuclear features

DOI: https://doi.org/10.1038/s41467-024-45421-w

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Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice

Fan, Yonggang; Zhang, Weixin; Huang, Xiusheng et al. · 2024

Full title: Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice

Authors: Fan, Yonggang; Zhang, Weixin; Huang, Xiusheng; Fan, Mingzhe; Shi, Chenhao; Zhao, Lantian; Pi, Guofu; Zhang, Huafeng; Ni, Shuangfei

DOI: https://doi.org/10.1038/s41467-024-47317-1

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Blocking negative effects of senescence in human skin fibroblasts with a plant extract

I. Lämmermann; Lucia Terlecki-Zaniewicz; R. Weinmüllner et al. · 2018

Full title: Blocking negative effects of senescence in human skin fibroblasts with a plant extract

DOI: https://doi.org/10.1038/s41514-018-0023-5

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Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia.

Li, Yang; Li, Chuhan; Zhou, Qin et al. · 2025

Full title: Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia.

Authors: Li, Yang; Li, Chuhan; Zhou, Qin; Liu, Xingyuan; Qiao, Yulong; Xie, Ting; Sun, Hao; Ong, Michael Tim-Yun; Wang, Huating

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Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease

Chiara, Letizia De; Conte, Carolina; Semeraro, Roberto et al. · 2022

Full title: Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease

DOI: https://doi.org/10.1038/s41467-022-33110-5

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Local H2 release remodels senescence microenvironment for improved repair of injured bone

Chen, Shengqiang; Yu, Yuanman; Xie, Songqing et al. · 2023

Full title: Local H2 release remodels senescence microenvironment for improved repair of injured bone

Authors: Chen, Shengqiang; Yu, Yuanman; Xie, Songqing; Liang, Danna; Shi, Wei; Chen, Sizhen; Li, Guanglin; Tang, Wei; Liu, Changsheng; He, Qianjun

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A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging

Linders, Annet N.; Dias, Itamar Braga; López‐Fernández, Teresa et al. · 2024

Full title: A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging

Authors: Linders, Annet N.; Dias, Itamar Braga; López‐Fernández, Teresa; Tocchetti, Carlo G.; Bömer, Nils; Meer, Peter van der

DOI: https://doi.org/10.1038/s41514-024-00135-7

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Increased vascular smooth muscle cell senescence in aneurysmal Fibulin-4 mutant mice.

Stefens, Sanne J M; van Vliet, Nicole; IJpma, Arne et al. · 2024

Full title: Increased vascular smooth muscle cell senescence in aneurysmal Fibulin-4 mutant mice.

DOI: https://doi.org/10.1038/s41514-024-00154-4

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The role of cellular senescence in ovarian aging.

Hense, Jéssica D; Isola, José V V; Garcia, Driele N et al. · 2024

Full title: The role of cellular senescence in ovarian aging.

Authors: Hense, Jéssica D; Isola, José V V; Garcia, Driele N; Magalhães, Larissa S; Masternak, Michal M; Stout, Michael B; Schneider, Augusto

DOI: https://doi.org/10.1038/s41514-024-00157-1

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Chemotherapy-induced adipo-lineage cell senescence drives bone loss.

Raut, Ganesh Kumar; Malachowski, Taylor; Melam, Anupama et al. · 2025

Full title: Chemotherapy-induced adipo-lineage cell senescence drives bone loss.

DOI: https://doi.org/10.1038/s41467-025-67793-3

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SGLT2 inhibitors as a novel senotherapeutic approach

Z. E. Yesilyurt-Dirican; Ce Qi; Yi-Chian Wang et al. · 2025

Full title: SGLT2 inhibitors as a novel senotherapeutic approach

Authors: Z. E. Yesilyurt-Dirican; Ce Qi; Yi-Chian Wang; Annika Simm; Laura Deelen; Alia Hafiz Abbas Gasim; Fiona C Lewis-McDougall; G. Ellison‐Hughes

DOI: https://doi.org/10.1038/s41514-025-00227-y

Paper

Senescence drives immunotherapy resistance by inducing an immunosuppressive tumor microenvironment

Maggiorani, Damien; Lê, Oanh; Lisi, Véronique et al. · 2024

Full title: Senescence drives immunotherapy resistance by inducing an immunosuppressive tumor microenvironment

Authors: Maggiorani, Damien; Lê, Oanh; Lisi, Véronique; Landais, Séverine; Moquin‐Beaudry, Gaël; Lavallée, Vincent‐Philippe; Decaluwe, Hélène; Beauséjour, Christian

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Longevity leap: mind the healthspan gap

Garmany, Armin; Yamada, Satsuki; Terzic, André · 2021

Full title: Longevity leap: mind the healthspan gap

Authors: Garmany, Armin; Yamada, Satsuki; Terzic, André

DOI: https://doi.org/10.1038/s41536-021-00169-5

Paper

Intermittent hypobaric pressure induces selective senescent cell death and alleviates age-related osteoporosis.

B. Meng; Yan Qu; Benyi Yang et al. · 2026

Full title: Intermittent hypobaric pressure induces selective senescent cell death and alleviates age-related osteoporosis.

Authors: B. Meng; Yan Qu; Benyi Yang; Chaoran Fu; Yifan He; Jing Li; Rentao Wan; Xin Li; Zhulin Xue; Zeyuan Cao; Meng Hao; Xiao Zhang; Zhe An; Fen Chen; Ruibao Ren; Xueli Mao; Yang Cao; Songtao Shi

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Advancing multiple sclerosis management in older adults

Walt, Anneke van der; Strijbis, Eva; Bridge, Francesca et al. · 2025

Full title: Advancing multiple sclerosis management in older adults

DOI: https://doi.org/10.1038/s41582-025-01115-5

Paper

COVID-19 and cellular senescence

Schmitt, Clemens A.; Tchkonia, Tamar; Niedernhofer, Laura J. et al. · 2022

Full title: COVID-19 and cellular senescence

Authors: Schmitt, Clemens A.; Tchkonia, Tamar; Niedernhofer, Laura J.; Robbins, Paul D.; Kirkland, James L.; Lee, Soyoung

DOI: https://doi.org/10.1038/s41577-022-00785-2

Paper

Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker.

Poblocka, Marta; Bassey, Akang Leonard; Smith, Victoria M et al. · 2021

Full title: Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker.

DOI: https://doi.org/10.1038/s41598-021-99852-2

Paper

Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF

Monkley, Susan J.; Overed-Sayer, Catherine; Parfrey, Helen et al. · 2021

Full title: Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF

DOI: https://doi.org/10.1038/s41598-021-00769-7

Paper

Cellular senescence-mediated exacerbation of Duchenne muscular dystrophy

Sugihara, Hidetoshi; Teramoto, Naomi; Nakamura, Katsuyuki et al. · 2020

Full title: Cellular senescence-mediated exacerbation of Duchenne muscular dystrophy

DOI: https://doi.org/10.1038/s41598-020-73315-6

Paper

GRP78/BiP determines senescence evasion cell fate after cisplatin-based chemotherapy

Zins Ei; Kanuengnit Choochuay; Alisa Tubsuwan et al. · 2021

Full title: GRP78/BiP determines senescence evasion cell fate after cisplatin-based chemotherapy

Authors: Zins Ei; Kanuengnit Choochuay; Alisa Tubsuwan; Decha Pinkaew; M. Suksomtip; C. Vinayanuwattikun; P. Chanvorachote; Preedakorn Chunhacha

DOI: https://doi.org/10.1038/s41598-021-01540-8

Paper

Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom Syndromes

Kim Jee Goh; Jian-hua Chen; N. Rocha et al. · 2020

Full title: Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom Syndromes

Authors: Kim Jee Goh; Jian-hua Chen; N. Rocha; R. Semple

DOI: https://doi.org/10.1038/s41598-020-64136-8

Paper

Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice

Acklin, Scarlett; Zhang, Manchao; Du, Wuying et al. · 2020

Full title: Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice

Authors: Acklin, Scarlett; Zhang, Manchao; Du, Wuying; Zhao, Xin; Plotkin, Matthew; Chang, Jianhui; Campisi, Judith; Zhou, Daohong; Xia, Fen

DOI: https://doi.org/10.1038/s41598-020-71042-6

Paper

Higher senescence associated secretory phenotype and lower defense mediator in urinary extracellular vesicles of elders with and without Parkinson disease

S. Yeh; Chia-Hsueh Lin; Yun-Jung Yang et al. · 2021

Full title: Higher senescence associated secretory phenotype and lower defense mediator in urinary extracellular vesicles of elders with and without Parkinson disease

Authors: S. Yeh; Chia-Hsueh Lin; Yun-Jung Yang; Li-Wei Lin; Chih-Wen Tseng; Kuender D Yang

DOI: https://doi.org/10.1038/s41598-021-95062-y

Paper

Advanced glycation end product (AGE) targeting antibody SIWA318H is efficacious in preclinical models for pancreatic cancer

Rossi, Gabriela R.; Jensen, Ashley W.; Ng, Serina et al. · 2023

Full title: Advanced glycation end product (AGE) targeting antibody SIWA318H is efficacious in preclinical models for pancreatic cancer

Authors: Rossi, Gabriela R.; Jensen, Ashley W.; Ng, Serina; Yin, Zhirong; Li, Aimin; Misra, Anjan; Hoff, Daniel D. Von; Gruber, Lewis; Gruber, Misty; Han, Haiyong

DOI: https://doi.org/10.1038/s41598-023-44211-6

Paper

A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD+ precursor combination.

Simon, Katherine E; Russell, Katharine; Mondino, Alejandra et al. · 2024

Full title: A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD+ precursor combination.

Authors: Simon, Katherine E; Russell, Katharine; Mondino, Alejandra; Yang, Chin-Chieh; Case, Beth C; Anderson, Zachary; Whitley, Christine; Griffith, Emily; Gruen, Margaret E; Olby, Natasha J

DOI: https://doi.org/10.1038/s41598-024-63031-w

Paper

Senolytic cocktail dasatinib and quercetin attenuates chronic high altitude hypoxia associated bone loss in mice

Shen Wang; Juan Zhai; Ke Heng et al. · 2024

Full title: Senolytic cocktail dasatinib and quercetin attenuates chronic high altitude hypoxia associated bone loss in mice

DOI: https://doi.org/10.1038/s41598-024-82262-5

Paper

Cellular senescence is associated with osteonecrosis of the femoral head while mesenchymal stem cell conditioned medium inhibits bone collapse

Okamoto, Masanori; Nakashima, Hiroaki; Sakai, Kiyoshi et al. · 2024

Full title: Cellular senescence is associated with osteonecrosis of the femoral head while mesenchymal stem cell conditioned medium inhibits bone collapse

Authors: Okamoto, Masanori; Nakashima, Hiroaki; Sakai, Kiyoshi; Takegami, Yasuhiko; Osawa, Yusuke; Watanabe, Junna; Ito, Sadayuki; Hibi, Hideharu; Imagama, Shiro

DOI: https://doi.org/10.1038/s41598-024-53400-w

Paper

Primary oocytes with cellular senescence features are involved in ovarian aging in mice

Hao Yan; Edgar Andres Diaz Miranda; Shiying Jin et al. · 2024

Full title: Primary oocytes with cellular senescence features are involved in ovarian aging in mice

Authors: Hao Yan; Edgar Andres Diaz Miranda; Shiying Jin; Faith Wilson; Kang An; Brooke Godbee; Xiaobin Zheng; Astrid Roshealy Brau-Rodríguez; Lei Lei

Paper

FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation

Yu-Xiang Kong; Zhi-Shuai Li; Yuanbo Liu et al. · 2025

Full title: FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation

Authors: Yu-Xiang Kong; Zhi-Shuai Li; Yuanbo Liu; Bo Pan; Xin Fu; Ran Xiao; Li Yan

DOI: https://doi.org/10.1038/s42003-025-07738-0

Paper

Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

Meiners, Franziska; Hinz, Burkhard; Boeckmann, Lars et al. · 2024

Full title: Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

Authors: Meiners, Franziska; Hinz, Burkhard; Boeckmann, Lars; Secci, Riccardo; Sueto, Salem Oduro Beffi; Kuepfer, Lars; Fuellen, Georg; Barrantes, Israel

Paper

An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence

C. Riviere-Cazaux; Lucas P Carlstrom; B. Neth et al. · 2023

Full title: An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence

DOI: https://doi.org/10.1038/s41698-023-00476-8

Paper

An effective system for senescence modulating drug development using quantitative high-content analysis and high-throughput screening

Hu, Yongfeng; Xue, Xueqi; Tian, Han et al. · 2025

Full title: An effective system for senescence modulating drug development using quantitative high-content analysis and high-throughput screening

Authors: Hu, Yongfeng; Xue, Xueqi; Tian, Han; Li, Ye; Zhang, Tonghui; Lu, Tao; Zhang, Peichuan

DOI: https://doi.org/10.1038/s42003-025-08758-6

Paper

SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

Shunya Tsuji; Shohei Minami; R. Hashimoto et al. · 2022

Full title: SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

DOI: https://doi.org/10.1038/s43587-022-00170-7

Paper

Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters

Lou Delval; Aline Hantute-Ghesquier; V. Sencio et al. · 2023

Full title: Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters

DOI: https://doi.org/10.1038/s43587-023-00442-w

Paper

IL-23R is a senescence-linked circulating and tissue biomarker of aging.

Carver, Chase M; Rodriguez, Sonia L; Atkinson, Elizabeth J et al. · 2025

Full title: IL-23R is a senescence-linked circulating and tissue biomarker of aging.

DOI: https://doi.org/10.1038/s43587-024-00752-7

Paper

Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome.

Gallage, Suchira; Irvine, Elaine E; Barragan Avila, Jose Efren et al. · 2024

Full title: Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome.

DOI: https://doi.org/10.1038/s43587-024-00695-z

Paper

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

Corina Amor; Inés Fernández-Maestre; Saria Chowdhury et al. · 2024

Full title: Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

DOI: https://theses.gla.ac.uk/82719/1/2021KiourtisPhD.pdf

Paper

Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish

Maï, Mounir El; Bird, Malia; Allouche, Asma et al. · 2023

Full title: Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish

DOI: https://doi.org/10.1038/s43587-023-00401-5

Paper

DNA nanoparticles targeting FOXO4 selectively eliminate cigarette smoke-induced senescent lung fibroblasts

HAN, YAOPIN; Wu, Yixing; He, Binfeng et al. · 2023

Full title: DNA nanoparticles targeting FOXO4 selectively eliminate cigarette smoke-induced senescent lung fibroblasts

Authors: HAN, YAOPIN; Wu, Yixing; He, Binfeng; Wu, Di; Hua, Jian-lan; Qian, Hang; Zhang, Jing

DOI: https://doi.org/10.1039/d3na00547j

Paper

In vitro study on effect of bardoxolone methyl on cisplatin-induced cellular senescence in human proximal tubular cells

Kurosaki, Yoshifumi; Imoto, Akemi; Kawakami, Fumitaka et al. · 2022

Full title: In vitro study on effect of bardoxolone methyl on cisplatin-induced cellular senescence in human proximal tubular cells

Authors: Kurosaki, Yoshifumi; Imoto, Akemi; Kawakami, Fumitaka; Ouchi, Motoshi; Morita, Asuka; Yokoba, Masanori; Takenaka, Tsuneo; Ichikawa, Takafumi; Katagiri, Masato; Nielsen, Rikke; Ishii, Naohito

DOI: https://doi.org/10.1007/s11010-021-04295-y

Paper

Dormant cancer cells: programmed quiescence, senescence, or both?

Truskowski, Kevin; Amend, Sarah R.; Pienta, Kenneth J. · 2023

Full title: Dormant cancer cells: programmed quiescence, senescence, or both?

Authors: Truskowski, Kevin; Amend, Sarah R.; Pienta, Kenneth J.

DOI: https://doi.org/10.1007/s10555-022-10073-z

Paper

Plasma dilution improves cognition and attenuates neuroinflammation in old mice.

Mehdipour, Melod; Mehdipour, Taha; Skinner, Colin M et al. · 2021

Full title: Plasma dilution improves cognition and attenuates neuroinflammation in old mice.

Authors: Mehdipour, Melod; Mehdipour, Taha; Skinner, Colin M; Wong, Nathan; Liu, Chao; Chen, Chia-Chien; Jeon, Ok Hee; Zuo, Yi; Conboy, Michael J; Conboy, Irina M

DOI: https://doi.org/10.1007/s11357-020-00297-8

Paper

Senescence, regulators of alternative splicing and effects of trametinib treatment in progeroid syndromes.

Bramwell, Laura R; Harries, Lorna W · 2024

Full title: Senescence, regulators of alternative splicing and effects of trametinib treatment in progeroid syndromes.

Authors: Bramwell, Laura R; Harries, Lorna W

DOI: https://doi.org/10.1007/s11357-023-00933-z

Paper

Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study

Fielding, Roger A.; Atkinson, Elizabeth J.; Aversa, Zaira et al. · 2022

Full title: Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study

DOI: https://doi.org/10.1007/s11357-022-00685-2

Paper

Senolytic intervention improves cognition, metabolism, and adiposity in female APPNL−F/NL−F mice

Yimin Fang; M. R. Peck; Kathleen Quinn et al. · 2023

Full title: Senolytic intervention improves cognition, metabolism, and adiposity in female APPNL−F/NL−F mice

Authors: Yimin Fang; M. R. Peck; Kathleen Quinn; Jenelle E. Chapman; David Medina; S. McFadden; Andrzej Bartke; K. Hascup; Erin R. Hascup

DOI: https://doi.org/10.1007/s11357-024-01308-8

Paper

Sexual dimorphic metabolic and cognitive responses of C57BL/6 mice to Fisetin or Dasatinib and quercetin cocktail oral treatment

Yimin Fang; David X. Medina; R. Stockwell et al. · 2021

Full title: Sexual dimorphic metabolic and cognitive responses of C57BL/6 mice to Fisetin or Dasatinib and quercetin cocktail oral treatment

Authors: Yimin Fang; David X. Medina; R. Stockwell; Samuel McFadden; Kathleen Quinn; M. R. Peck; A. Bartke; K. Hascup; Erin R. Hascup

DOI: https://doi.org/10.1007/s11357-023-00843-0

Paper

The Interplay Between Autophagy and Senescence in Anthracycline Cardiotoxicity

Russo, Michele; Bono, Enrico; Ghigo, Alessandra · 2021

Full title: The Interplay Between Autophagy and Senescence in Anthracycline Cardiotoxicity

Authors: Russo, Michele; Bono, Enrico; Ghigo, Alessandra

DOI: https://doi.org/10.1007/s11897-021-00519-w

Paper

Cerebromicrovascular senescence in vascular cognitive impairment: does accelerated microvascular aging accompany atherosclerosis?

Ungvari, Anna; Nyúl-Tóth, Ádám; Patai, Roland et al. · 2025

Full title: Cerebromicrovascular senescence in vascular cognitive impairment: does accelerated microvascular aging accompany atherosclerosis?

Authors: Ungvari, Anna; Nyúl-Tóth, Ádám; Patai, Roland; Csik, Boglarka; Gulej, Rafal; Nagy, Dorina; Shanmugarama, Santny; Benyó, Zoltán; Kiss, Tamas; Ungvari, Zoltan; Csiszar, Anna

DOI: https://doi.org/10.1007/s11357-025-01621-w

Paper

The senescence-inhibitory p53 isoform Δ133p53α: enhancing cancer immunotherapy and exploring novel therapeutic approaches for senescence-associated diseases

Nakamichi, Shinji; Yamada, Leo; Roselle, Christopher et al. · 2025

Full title: The senescence-inhibitory p53 isoform Δ133p53α: enhancing cancer immunotherapy and exploring novel therapeutic approaches for senescence-associated diseases

Authors: Nakamichi, Shinji; Yamada, Leo; Roselle, Christopher; Horikawa, Izumi; June, Carl H.; Harris, Curtis C.

DOI: https://doi.org/10.1007/s11357-025-01819-y

Paper

NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse populations

Driscoll, Monica; Sedore, Christine A.; Onken, Brian et al. · 2025

Authors: Driscoll, Monica; Sedore, Christine A.; Onken, Brian; Coleman-Hulbert, Anna L; Johnson, Erik; Phillips, Patrick C.; Lithgow, Gordon J.

DOI: https://doi.org/10.1007/s11357-025-01627-4

Paper

The anti-senescence effect of D-β-hydroxybutyrate in Hutchinson-Gilford progeria syndrome involves progerin clearance by the activation of the AMPK-mTOR-autophagy pathway

Monterrubio-Ledezma, Feliciano; Salcido-Gómez, Ashley; Zavaleta-Vásquez, Tania Ivette et al. · 2025

Full title: The anti-senescence effect of D-β-hydroxybutyrate in Hutchinson-Gilford progeria syndrome involves progerin clearance by the activation of the AMPK-mTOR-autophagy pathway

Authors: Monterrubio-Ledezma, Feliciano; Salcido-Gómez, Ashley; Zavaleta-Vásquez, Tania Ivette; Navarro‐García, Fernando; Cisneros, Bulmaro; Massieu, Lourdes

DOI: https://doi.org/10.1007/s11357-024-01501-9

Paper

Senotherapeutics in Malignant Brain Cancer Therapy.

Kaina, Bernd; Christmann, Markus · 2025

Full title: Senotherapeutics in Malignant Brain Cancer Therapy.

Authors: Kaina, Bernd; Christmann, Markus

DOI: https://doi.org/10.1007/s11912-025-01733-8

Paper

Increased cellular senescence in doxorubicin-induced murine ovarian injury: effect of senolytics.

Gao, Yueyue; Wu, Tong; Tang, Xianan et al. · 2023

Full title: Increased cellular senescence in doxorubicin-induced murine ovarian injury: effect of senolytics.

Authors: Gao, Yueyue; Wu, Tong; Tang, Xianan; Wen, Jingyi; Zhang, Yan; Zhang, Jinjin; Wang, Shixuan

DOI: https://doi.org/10.1007/s11357-023-00728-2

Paper

Targeted clearance of senescent cells alleviates alcohol-associated liver disease by restoring cellular function and immune balance.

Tian, Tian; Xue, Yuhua; Song, Zhewei et al. · 2025

Full title: Targeted clearance of senescent cells alleviates alcohol-associated liver disease by restoring cellular function and immune balance.

Authors: Tian, Tian; Xue, Yuhua; Song, Zhewei; Jin-Smith, Brady; Barkin, Joshua; Ottallah, Melak; Mannan, Mahfuza; Zhirkova, Arina; Zhou, Daohong; Pi, Liya

DOI: https://doi.org/10.1007/s11357-025-01952-8

Paper

Cell Senescence in Lupus

Gao, Lin; Slack, Maria A.; McDavid, Andrew et al. · 2019

Full title: Cell Senescence in Lupus

Authors: Gao, Lin; Slack, Maria A.; McDavid, Andrew; Anolik, Jennifer H.; Looney, R. John

DOI: https://doi.org/10.1007/s11926-019-0800-6

Paper

Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review

Amaya-Montoya, Mateo; Pérez-Londoño, Agustín; Guatibonza-García, Valentina et al. · 2020

Full title: Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review

Authors: Amaya-Montoya, Mateo; Pérez-Londoño, Agustín; Guatibonza-García, Valentina; Vargas-Villanueva, Andrea; Mendivil, Carlos O.

DOI: https://doi.org/10.1007/s12325-020-01287-0

Paper

Cellular senescence in the aging and diseased kidney.

Valentijn, F A; Falke, L L; Nguyen, T Q et al. · 2018

Full title: Cellular senescence in the aging and diseased kidney.

Authors: Valentijn, F A; Falke, L L; Nguyen, T Q; Goldschmeding, Roel

DOI: https://doi.org/10.1007/s12079-017-0434-2

Paper

Elimination of docetaxel-induced senescence attenuates malignant progression in RB1-deficient CRPC.

Su, Huilan; Huang, Liqun; Xia, Wenwen et al. · 2025

Full title: Elimination of docetaxel-induced senescence attenuates malignant progression in RB1-deficient CRPC.

Authors: Su, Huilan; Huang, Liqun; Xia, Wenwen; Tang, Dean G; Zhou, Jianjun; Yang, Guosheng

DOI: https://doi.org/10.1007/s13402-025-01126-w

Paper

Senolytics: charting a new course or enhancing existing anti-tumor therapies?

Czajkowski, Konrad; Herbet, Mariola; Murias, Marek et al. · 2025

Full title: Senolytics: charting a new course or enhancing existing anti-tumor therapies?

Authors: Czajkowski, Konrad; Herbet, Mariola; Murias, Marek; Piątkowska-Chmiel, Iwona

DOI: https://doi.org/10.1007/s13402-024-01018-5

Paper

A senolysis-targeting bioenergetic nanoplatform for diabetic wound healing

Zijun Zheng; Xuerong Wei; Ziwei Jiang et al. · 2025

Full title: A senolysis-targeting bioenergetic nanoplatform for diabetic wound healing

Authors: Zijun Zheng; Xuerong Wei; Ziwei Jiang; Daping Xie; Pengwei Shi; Jun Ma; Qiuyi Yu; Yufang He; Aizhong Pang; Jinyuan Zeng; Yanbin Gao; Chunming Wang; Lei Yang

DOI: https://doi.org/10.1007/s42114-025-01509-5

Paper

Aging and tumors: a dynamic interaction

Zhang, Yudi; Zhu, Siqiang; Liu, Zhaodong et al. · 2025

Full title: Aging and tumors: a dynamic interaction

Authors: Zhang, Yudi; Zhu, Siqiang; Liu, Zhaodong; Hu, Yonghao; Zhang, Yongjian; Shang, Liang; Li, Leping

DOI: https://doi.org/10.1007/s12672-025-01808-9

Paper

Talazoparib and radiation enhance the senolytic efficacy of venetoclax in therapy-induced senescent triple-negative breast cancer cells

Sultan Almudimeegh; M. Almutairi; Abrar Softah et al. · 2025

Full title: Talazoparib and radiation enhance the senolytic efficacy of venetoclax in therapy-induced senescent triple-negative breast cancer cells

Authors: Sultan Almudimeegh; M. Almutairi; Abrar Softah; Khalid Alhazzani; Lama Binobaid; Musaad A. Alshammari; H. A. Sobeai; Tareq Saleh; M. Alotaibi; Ali R. Alhoshani

DOI: https://doi.org/10.1007/s44446-025-00034-2

Paper

Idiopathic Pulmonary Fibrosis, Today and Tomorrow: Certainties and New Therapeutic Horizons

Giulianelli, Giacomo; Cocconcelli, Elisabetta; Fiorentù, Giordano et al. · 2025

Full title: Idiopathic Pulmonary Fibrosis, Today and Tomorrow: Certainties and New Therapeutic Horizons

Authors: Giulianelli, Giacomo; Cocconcelli, Elisabetta; Fiorentù, Giordano; Bernardinello, Nicol; Balestro, Elisabetta; Spagnolo, Paolo

DOI: https://doi.org/10.1007/s41030-025-00296-0

Paper

Repurposing Drugs for Diabetes Mellitus as Potential Pharmacological Treatments for Sarcopenia – A Narrative Review

Witham, Miles D.; Granic, Antoneta; Pearson, Ewan R. et al. · 2023

Full title: Repurposing Drugs for Diabetes Mellitus as Potential Pharmacological Treatments for Sarcopenia – A Narrative Review

Authors: Witham, Miles D.; Granic, Antoneta; Pearson, Ewan R.; Robinson, Siân; Sayer, Avan Aihie

DOI: https://doi.org/10.1007/s40266-023-01042-4

Paper

Pharmacotherapies in Older Adults with COPD: Challenges and Opportunities.

Matera, Maria Gabriella; Hanania, Nicola A; Maniscalco, Mauro et al. · 2023

Full title: Pharmacotherapies in Older Adults with COPD: Challenges and Opportunities.

Authors: Matera, Maria Gabriella; Hanania, Nicola A; Maniscalco, Mauro; Cazzola, Mario

DOI: https://doi.org/10.1007/s40266-023-01038-0

Paper

Human proximal tubular epithelial cell interleukin-1 receptor signalling triggers G2/M arrest and cellular senescence during hypoxic kidney injury.

Giuliani, Kurt T K; Nag, Purba; Adams, Benjamin C et al. · 2025

Full title: Human proximal tubular epithelial cell interleukin-1 receptor signalling triggers G2/M arrest and cellular senescence during hypoxic kidney injury.

DOI: https://doi.org/10.1038/s41419-025-07386-6

Paper

Monovalent ions and stress-induced senescence in human mesenchymal endometrial stem/stromal cells

Shatrova, Alla; Burova, Elena; Pugovkina, Natalja et al. · 2022

Full title: Monovalent ions and stress-induced senescence in human mesenchymal endometrial stem/stromal cells

Authors: Shatrova, Alla; Burova, Elena; Pugovkina, Natalja; Домнина, А. П.; Nikolsky, Nikolaj; Marakhova, I I

DOI: https://doi.org/10.1038/s41598-022-15490-2

Paper

In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers

Parinya Samakkarnthai; D. Saul; Lei Zhang et al. · 2023

Full title: In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers

DOI: https://doi.org/10.1101/2023.02.23.529777

Paper

Senescence in Vascular Smooth Muscle Cells and Atherosclerosis

Zha, Yiwen; Zhuang, Wenwen; Yang, Yongqi et al. · 2022

Full title: Senescence in Vascular Smooth Muscle Cells and Atherosclerosis

Authors: Zha, Yiwen; Zhuang, Wenwen; Yang, Yongqi; Zhou, Yue; Li, Hongliang; Liang, Jingyan

DOI: https://doi.org/10.3389/fcvm.2022.910580

Paper

Fisetin Attenuated Oxidative Stress-Induced Cellular Damage in ARPE-19 Human Retinal Pigment Epithelial Cells Through Nrf2-Mediated Activation of Heme Oxygenase-1

Park, Cheol; Noh, Jeong Sook; Jung, Youngmi et al. · 2022

Full title: Fisetin Attenuated Oxidative Stress-Induced Cellular Damage in ARPE-19 Human Retinal Pigment Epithelial Cells Through Nrf2-Mediated Activation of Heme Oxygenase-1

Authors: Park, Cheol; Noh, Jeong Sook; Jung, Youngmi; Leem, Sun‐Hee; Hyun, Jin Won; Chang, Young‐Chae; Kwon, Taeg Kyu; Kim, Gi‐Young; Lee, Hyesook; Choi, Yung Hyun

DOI: https://doi.org/10.3389/fphar.2022.927898

Thesis

Novel insights into protein synthesis rates in the brain following two lifespan-extending treatments

Reid, Justin, author; Hamilton, Karyn, advisor; Miller, Benjamin, advisor et al. · 2018

Full title: Novel insights into protein synthesis rates in the brain following two lifespan-extending treatments

Authors: Reid, Justin, author; Hamilton, Karyn, advisor; Miller, Benjamin, advisor; Tsunoda, Susan, committee member

DOI: https://hdl.handle.net/10217/191325

Thesis

A study on the systemic transmission of cellular senescence and its role in acute liver failure

Kiourtis, Christos · 2021

Full title: A study on the systemic transmission of cellular senescence and its role in acute liver failure

Authors: Kiourtis, Christos

Thesis

Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects.

Strong, Randy; Miller, Richard A; Bogue, Molly et al. · 2020

Full title: Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects.

DOI: https://www.repository.cam.ac.uk/handle/1810/312679

Thesis

Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk.

Cassidy, Liam D; Young, Andrew RJ; Young, Christopher NJ et al. · 2019

Full title: Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk.

DOI: https://www.repository.cam.ac.uk/handle/1810/300207

Thesis

Basic research: Killing the old: cell senescence in atherosclerosis

Bennett, MR; Clarke, MCH · 2017

Full title: Basic research: Killing the old: cell senescence in atherosclerosis

Authors: Bennett, MR; Clarke, MCH

DOI: https://www.repository.cam.ac.uk/handle/1810/262681

Thesis

Targeting senescent cells in translational medicine.

Paez-Ribes, Marta; González-Gualda, Estela; Doherty, Gary J et al. · 2019

Full title: Targeting senescent cells in translational medicine.

Authors: Paez-Ribes, Marta; González-Gualda, Estela; Doherty, Gary J; Muñoz-Espín, Daniel

DOI: https://www.repository.cam.ac.uk/handle/1810/300243

Thesis

Latest Advances in Aging Research and Drug Discovery

Rubinsztein, David · 2019

Full title: Latest Advances in Aging Research and Drug Discovery

Authors: Rubinsztein, David

DOI: https://www.repository.cam.ac.uk/handle/1810/298873

Thesis

SARS-CoV-2-induced senescence as a potential therapeutic target.

Denholm, Mary; Rintoul, Robert C; Muñoz-Espín, Daniel · 2022

Full title: SARS-CoV-2-induced senescence as a potential therapeutic target.

Authors: Denholm, Mary; Rintoul, Robert C; Muñoz-Espín, Daniel

DOI: https://www.repository.cam.ac.uk/handle/1810/339735

Thesis

Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration

Delenko, J; Hyman, N; Chatterjee, PK et al. · 2025

Full title: Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration

Authors: Delenko, J; Hyman, N; Chatterjee, PK; Safaric Tepes, P; Shih, AJ; Xue, X; Gurney, J; Baker, AG; Wei, C; Munoz Espin, D; Fruk, L; Gregersen, PK; Metz, CN

DOI: https://www.repository.cam.ac.uk/handle/1810/385882

Thesis

Brain Cell Senescence: A New Therapeutic Target for the Acute Treatment of Ischemic Stroke.

Baixauli-Martín, Júlia; Aliena-Valero, Alicia; Castelló-Ruiz, María et al. · 2023

Full title: Brain Cell Senescence: A New Therapeutic Target for the Acute Treatment of Ischemic Stroke.

Authors: Baixauli-Martín, Júlia; Aliena-Valero, Alicia; Castelló-Ruiz, María; Burguete, María C; López-Morales, Mikahela A; Muñoz-Espín, Daniel; Torregrosa, Germán; Salom, Juan B

DOI: https://www.repository.cam.ac.uk/handle/1810/362109

Thesis

Improved Therapeutic Efficiency of Senescent Cell-specific, Galactose-Functionalized Micelle Nanocarriers

Fruk, Ljiljana; Baker, Andrew; Badri, Parshad et al. · 2024

Full title: Improved Therapeutic Efficiency of Senescent Cell-specific, Galactose-Functionalized Micelle Nanocarriers

Authors: Fruk, Ljiljana; Baker, Andrew; Badri, Parshad; Ahmed, Ishtiaq; Esteoa-Fernandez, Alejandra; Munoz-Espin, Daniel

DOI: https://www.repository.cam.ac.uk/handle/1810/377424

Thesis

Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer.

Haston, Scott; Gonzalez-Gualda, Estela; Morsli, Samir et al. · 2023

Full title: Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer.

DOI: https://www.repository.cam.ac.uk/handle/1810/362100

Thesis

Author Correction: Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog

Magkouta, Sophia; Veroutis, Dimitris; Papaspyropoulos, Angelos et al. · 2025

Full title: Author Correction: Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog

DOI: https://www.repository.cam.ac.uk/handle/1810/381668

Thesis

Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog.

Magkouta, Sophia; Veroutis, Dimitris; Papaspyropoulos, Angelos et al. · 2025

Full title: Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog.

DOI: https://www.repository.cam.ac.uk/handle/1810/379233

Thesis

Microdose lithium reduces cellular senescence in human astrocytes - a potential pharmacotherapy for COVID-19?

Andersen, Julie · 2020

Full title: Microdose lithium reduces cellular senescence in human astrocytes - a potential pharmacotherapy for COVID-19?

Authors: Andersen, Julie