Cho Cell Feeding Strategies For Titer Optimization
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PaperGrowth hormone regulation of DNA replication, but not insulin production, is partly mediated by somatomedin-C/insulin-like growth factor I in isolated pancreatic islets from adult rats
Full title: Growth hormone regulation of DNA replication, but not insulin production, is partly mediated by somatomedin-C/insulin-like growth factor I in isolated pancreatic islets from adult rats
PaperCombination of strong anion exchange liquid chromatography with microchip capillary electrophoresis sodium dodecyl sulfate for rapid two-dimensional separations of complex protein mixtures
Zagst, Holger, Elgert, Christin, Behrends, Sönke, Wätzig, Hermann · 2021 · Analytical and Bioanalytical Chemistry · DOI
Full title: Combination of strong anion exchange liquid chromatography with microchip capillary electrophoresis sodium dodecyl sulfate for rapid two-dimensional separations of complex protein mixtures
Authors: Zagst, Holger, Elgert, Christin, Behrends, Sönke, Wätzig, Hermann
PaperBioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production
Tapia, Felipe, Vázquez-Ramírez, Daniel, Genzel, Yvonne, Reichl, Udo · 2016 · Applied Microbiology and Biotechnology · DOI
Full title: Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production
PaperCompartment-specific metabolome labeling enables the identification of subcellular fluxes that may serve as promising metabolic engineering targets in CHO cells
Wijaya, Andy Wiranata, Ulmer, Andreas, Hundsdorfer, Lara, Verhagen, Natascha, Teleki, Attila, Takors, Ralf · 2021 · Bioprocess and Biosystems Engineering · DOI
Full title: Compartment-specific metabolome labeling enables the identification of subcellular fluxes that may serve as promising metabolic engineering targets in CHO cells
PaperCulture media selection and feeding strategy for high titer production of a lentiviral vector by stable producer clones cultivated at high cell density
Full title: Culture media selection and feeding strategy for high titer production of a lentiviral vector by stable producer clones cultivated at high cell density
PaperEnhancement of recombinant human IL-24 (rhIL-24) protein production from site-specific integrated engineered CHO cells by sodium butyrate treatment.
Hua, Jilei, Xu, Hanli, Zhang, Yao, Ge, Jianlin, Liu, Mengzhe, Wang, Yuqi, Wei, Yuexian, Shi, Yinan, Hou, LingLing, Jiang, Hong · 2022 · Bioprocess and biosystems engineering · DOI
Full title: Enhancement of recombinant human IL-24 (rhIL-24) protein production from site-specific integrated engineered CHO cells by sodium butyrate treatment.
PaperImpact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins
Wolnick, Nicolas, Dickson, Marissa, Webster, Thaddaeus A., Connolly, Roger P., Fernandes, Nancy, Encheva, Vesela, Crittenden, Hunter, Hodgkins, Jessica, Hadley, Brian C., Palermo, Gabriella, Hendrick, Shannon, Newell, Roy A., Gray, Genevieve, Siltanen, Christian, Armstrong, Julia, Downey, Brandon, Mason, Carrie · 2024 · Bioprocess and Biosystems Engineering · DOI
Full title: Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins
Authors: Wolnick, Nicolas, Dickson, Marissa, Webster, Thaddaeus A., Connolly, Roger P., Fernandes, Nancy, Encheva, Vesela, Crittenden, Hunter, Hodgkins, Jessica, Hadley, Brian C., Palermo, Gabriella, Hendrick, Shannon, Newell, Roy A., Gray, Genevieve, Siltanen, Christian, Armstrong, Julia, Downey, Brandon, Mason, Carrie
PaperAmino acid consumption in naïve and recombinant CHO cell cultures: producers of a monoclonal antibody.
Carrillo-Cocom, L M, Genel-Rey, T, Araíz-Hernández, D, López-Pacheco, F, López-Meza, J, Rocha-Pizaña, M R, Ramírez-Medrano, A, Alvarez, M M · 2015 · Cytotechnology · DOI
Full title: Amino acid consumption in naïve and recombinant CHO cell cultures: producers of a monoclonal antibody.
Authors: Carrillo-Cocom, L M, Genel-Rey, T, Araíz-Hernández, D, López-Pacheco, F, López-Meza, J, Rocha-Pizaña, M R, Ramírez-Medrano, A, Alvarez, M M
PaperHoney bee colonies provided with natural forage have lower pathogen loads and higher overwinter survival than those fed protein supplements
G. DeGrandi-Hoffman, Yanping Chen, R. Rivera, M. Carroll, Mona Chambers, Geoffrey Hidalgo, Emily Watkins Jong · 2015 · Apidologie · DOI
Full title: Honey bee colonies provided with natural forage have lower pathogen loads and higher overwinter survival than those fed protein supplements
Authors: G. DeGrandi-Hoffman, Yanping Chen, R. Rivera, M. Carroll, Mona Chambers, Geoffrey Hidalgo, Emily Watkins Jong
PaperDietary L-arginine supplementation improves the intestinal development through increasing mucosal Akt and mammalian target of rapamycin signals in intra-uterine growth retarded piglets.
Yuanxiao Wang, Lili Zhang, Genlai Zhou, Zhiyong Liao, H. Ahmad, Wen‐bin Liu, Tian Wang · 2012 · British Journal of Nutrition · DOI
Full title: Dietary L-arginine supplementation improves the intestinal development through increasing mucosal Akt and mammalian target of rapamycin signals in intra-uterine growth retarded piglets.
Authors: Yuanxiao Wang, Lili Zhang, Genlai Zhou, Zhiyong Liao, H. Ahmad, Wen‐bin Liu, Tian Wang
PaperGenome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
Gutierrez, Jahir M., Feizi, Amir, Li, Shangzhong, Kallehauge, Thomas Beuchert, Hefzi, Hooman, Grav, Lise Marie, Ley, Daniel, Hızal, Deniz Baycın, Betenbaugh, Michael J., Voldborg, Björn G., Kildegaard, Helene Faustrup, Lee, Gyun Min, Palsson, Bernhard Ø., Nielsen, Jens, Lewis, Nathan E. · 2020 · Nature Communications · DOI
Full title: Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
Authors: Gutierrez, Jahir M., Feizi, Amir, Li, Shangzhong, Kallehauge, Thomas Beuchert, Hefzi, Hooman, Grav, Lise Marie, Ley, Daniel, Hızal, Deniz Baycın, Betenbaugh, Michael J., Voldborg, Björn G., Kildegaard, Helene Faustrup, Lee, Gyun Min, Palsson, Bernhard Ø., Nielsen, Jens, Lewis, Nathan E.
PaperEffect of cereal soaking and carbohydrase supplementation on growth, nutrient digestibility and intestinal microbiota in liquid-fed grow-finishing pigs.
Torres-Pitarch, Alberto, Gardiner, Gillian E, Cormican, Paul, Rea, Mary, Crispie, Fiona, O'Doherty, John V, Cozannet, Pierre, Ryan, Tomas, Lawlor, Peadar G · 2020 · Scientific reports · DOI
Full title: Effect of cereal soaking and carbohydrase supplementation on growth, nutrient digestibility and intestinal microbiota in liquid-fed grow-finishing pigs.
Authors: Torres-Pitarch, Alberto, Gardiner, Gillian E, Cormican, Paul, Rea, Mary, Crispie, Fiona, O'Doherty, John V, Cozannet, Pierre, Ryan, Tomas, Lawlor, Peadar G
PaperImproved performance of a rainbow trout selected strain is associated with protein digestion rates and synchronization of amino acid absorption.
Brezas, Andreas, Hardy, Ronald W · 2020 · Scientific reports · DOI
Full title: Improved performance of a rainbow trout selected strain is associated with protein digestion rates and synchronization of amino acid absorption.
PaperDevelopment of serum-free and grain-derived-nutrient-free medium using microalga-derived nutrients and mammalian cell-secreted growth factors for sustainable cultured meat production
Full title: Development of serum-free and grain-derived-nutrient-free medium using microalga-derived nutrients and mammalian cell-secreted growth factors for sustainable cultured meat production
PaperDiscovery of l-threonine transaldolases for enhanced biosynthesis of beta-hydroxylated amino acids
Michaela A Jones, Neil D. Butler, Shelby R. Anderson, Sean A Wirt, Ishika Govil, Xinyi Lyu, Yinzhi Fang, Aditya M. Kunjapur · 2023 · Communications Biology · DOI
Full title: Discovery of l-threonine transaldolases for enhanced biosynthesis of beta-hydroxylated amino acids
Authors: Michaela A Jones, Neil D. Butler, Shelby R. Anderson, Sean A Wirt, Ishika Govil, Xinyi Lyu, Yinzhi Fang, Aditya M. Kunjapur
Guokai Yan, R. Lestari, Baisheng Long, Qiwen Fan, Zhichang Wang, Xiaozhen Guo, Jie Yu, Jun Hu, Xingya Yang, Changqing Chen, Lu Liu, Xiuzhi Li, A. Purnomoadi, J. Achmadi, Xianghua Yan · 2016 · Scientific Reports · DOI
Full title: Comparative Proteomics Analysis Reveals L-Arginine Activates Ethanol Degradation Pathways in HepG2 Cells
Authors: Guokai Yan, R. Lestari, Baisheng Long, Qiwen Fan, Zhichang Wang, Xiaozhen Guo, Jie Yu, Jun Hu, Xingya Yang, Changqing Chen, Lu Liu, Xiuzhi Li, A. Purnomoadi, J. Achmadi, Xianghua Yan
PaperRibosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion
Kallehauge, Thomas Beuchert, Li, Shangzhong, Pedersen, Lasse Ebdrup, Ha, Tae Kwang, Ley, Daniel, Andersen, Mikael Rørdam, Kildegaard, Helene Faustrup, Lee, Gyun Min, Lewis, Nathan E. · 2017 · Scientific Reports · DOI
Full title: Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion
Authors: Kallehauge, Thomas Beuchert, Li, Shangzhong, Pedersen, Lasse Ebdrup, Ha, Tae Kwang, Ley, Daniel, Andersen, Mikael Rørdam, Kildegaard, Helene Faustrup, Lee, Gyun Min, Lewis, Nathan E.
PaperSupply of methionine and arginine alters phosphorylation of mechanistic target of rapamycin (mTOR), circadian clock proteins, and α-s1-casein abundance in bovine mammary epithelial cells.
Liangyu Hu, Yifei Chen, Ismael M Cortes, D. Coleman, H. Dai, Yusheng Liang, C. Parys, C. Fernández, Mengzhi Wang, J. Loor · 2020 · Food & Function · DOI
Full title: Supply of methionine and arginine alters phosphorylation of mechanistic target of rapamycin (mTOR), circadian clock proteins, and α-s1-casein abundance in bovine mammary epithelial cells.
Authors: Liangyu Hu, Yifei Chen, Ismael M Cortes, D. Coleman, H. Dai, Yusheng Liang, C. Parys, C. Fernández, Mengzhi Wang, J. Loor
PaperMetabolic flux analysis: a comprehensive review on sample preparation, analytical techniques, data analysis, computational modelling, and main application areas
Falco, Bruna de, Giannino, Francesco, Cartenì, Fabrizio, Mazzoleni, Stefano, Kim, Dong‐Hyun · 2022 · RSC Advances · DOI
Full title: Metabolic flux analysis: a comprehensive review on sample preparation, analytical techniques, data analysis, computational modelling, and main application areas
Authors: Falco, Bruna de, Giannino, Francesco, Cartenì, Fabrizio, Mazzoleni, Stefano, Kim, Dong‐Hyun
PaperThe influence of force feeding and of protein supplementation to the diet on the metabolisable energy of diets, digestibility of nutrients, nitrogen retention and digestive enzymes output in geese.
Nir, I, Nitsan, Z, Vax, A · 1973 · Annales de biologie animale, biochimie, biophysique · DOI
Full title: The influence of force feeding and of protein supplementation to the diet on the metabolisable energy of diets, digestibility of nutrients, nitrogen retention and digestive enzymes output in geese.
Authors: Nir, I, Nitsan, Z, Vax, A
Year: 1973
Venue: Annales de biologie animale, biochimie, biophysique
PaperThe effect of supplemental propionate on insulin responsiveness to glucose and tissue responsiveness to insulin in relation to feeding in sheep.
Sano, H, Terashima, Y · 1998 · Reproduction, nutrition, development · DOI
Full title: The effect of supplemental propionate on insulin responsiveness to glucose and tissue responsiveness to insulin in relation to feeding in sheep.
PaperGlycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster ovary fed-batch cultures
Hutter, Sandro, Villiger, Thomas K., Brühlmann, David, Stettler, Matthieu, Broly, Hervé, Šoóš, Miroslav, Gunawan, Rudiyanto · 2017 · DOI
Full title: Glycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster ovary fed-batch cultures
Authors: Hutter, Sandro, Villiger, Thomas K., Brühlmann, David, Stettler, Matthieu, Broly, Hervé, Šoóš, Miroslav, Gunawan, Rudiyanto
PaperAnalysis of coagulation factor IX in bioreactor cell culture medium predicts yield and quality of the purified product
Zacchi, Lucía F., Recinos, Dinora Roche, Pegg, Cassandra L., Phung, Toan K., Napoli, Mark, Aitken, Campbell, Sandford, Vanessa, Mahler, Stephen M., Lee, Yih Yean, Schulz, Benjamin L., Howard, Christopher B. · 2020 · DOI
Full title: Analysis of coagulation factor IX in bioreactor cell culture medium predicts yield and quality of the purified product
Authors: Zacchi, Lucía F., Recinos, Dinora Roche, Pegg, Cassandra L., Phung, Toan K., Napoli, Mark, Aitken, Campbell, Sandford, Vanessa, Mahler, Stephen M., Lee, Yih Yean, Schulz, Benjamin L., Howard, Christopher B.
PaperEssentially leading antibody production: An investigation of amino acids, myeloma and natural V-region signal peptides in producing Pertuzumab and Trastuzumab variants
Ling, Wei‐Li, Su, Chinh Tran-To, Lua, Wai‐Heng, Poh, Jun-Jie, Ng, Yuen-Ling, Wipat, Anil, Gan, Samuel Ken‐En · 2020 · DOI
Full title: Essentially leading antibody production: An investigation of amino acids, myeloma and natural V-region signal peptides in producing Pertuzumab and Trastuzumab variants
Authors: Ling, Wei‐Li, Su, Chinh Tran-To, Lua, Wai‐Heng, Poh, Jun-Jie, Ng, Yuen-Ling, Wipat, Anil, Gan, Samuel Ken‐En
PaperEvaluating the potential of marine invertebrate and insect protein hydrolysates to reduce fetal bovine serum in cell culture media for cultivated fish production
Full title: Evaluating the potential of marine invertebrate and insect protein hydrolysates to reduce fetal bovine serum in cell culture media for cultivated fish production
PaperTemporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch and Perfusion Bioreactor Operation
Gyorgypal, Aron, Fratz‐Berilla, Erica J., Kohnhorst, Casey, Powers, David N., Chundawat, Shishir P. S. · 2023 · DOI
Full title: Temporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch and Perfusion Bioreactor Operation
Authors: Gyorgypal, Aron, Fratz‐Berilla, Erica J., Kohnhorst, Casey, Powers, David N., Chundawat, Shishir P. S.
PaperEngineered autocrine signaling eliminates muscle cell FGF2 requirements for cultured meat production
Stout, Andrew J., Zhang, Xiaoli, Letcher, Sophia M., Rittenberg, Miriam L., Shub, Michelle, Chai, Kristin M., Kaul, Maya, Kaplan, David L. · 2023 · DOI
Full title: Engineered autocrine signaling eliminates muscle cell FGF2 requirements for cultured meat production
Authors: Stout, Andrew J., Zhang, Xiaoli, Letcher, Sophia M., Rittenberg, Miriam L., Shub, Michelle, Chai, Kristin M., Kaul, Maya, Kaplan, David L.
PaperEvaluation of Plant- and Microbial-Derived Protein Hydrolysates as Substitutes for Fetal Bovine Serum in Cultivated Seafood Cell Culture Media
Arian Amirvaresi, Reza Ovissipour · 2024 · bioRxiv · DOI
Full title: Evaluation of Plant- and Microbial-Derived Protein Hydrolysates as Substitutes for Fetal Bovine Serum in Cultivated Seafood Cell Culture Media
PaperComparing Kinetic versus Stoichiometric Priorities in Hybrid Models of CHO Metabolism
Khare, Pratik, Ndahiro, Nelson, Klaubert, Stephanie R., Ma, Edward, Bertalan, Tom, Kevrekidis, Ioannis G., Harcum, Sarah W., Betenbaugh, Michael J. · 2025 · DOI
Full title: Comparing Kinetic versus Stoichiometric Priorities in Hybrid Models of CHO Metabolism
Authors: Khare, Pratik, Ndahiro, Nelson, Klaubert, Stephanie R., Ma, Edward, Bertalan, Tom, Kevrekidis, Ioannis G., Harcum, Sarah W., Betenbaugh, Michael J.
PaperExpression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family.
Bierhuizen, Marti F.A., Mattéi, Marie‐Geneviève, Fukuda, Minoru · 1993 · Genes & Development · DOI
Full title: Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family.
PaperSynergizing metabolic flux analysis and nucleotide sugar metabolism to understand the control of glycosylation of recombinant protein in CHO cells
Burleigh, Susan C, Laar, Teun van de, Stroop, Corné J.M., Grunsven, Wout MJ van, O’Donoghue, Niaobh, Rudd, Pauline M., Davey, Gavin P. · 2011 · BMC Biotechnology · DOI
Full title: Synergizing metabolic flux analysis and nucleotide sugar metabolism to understand the control of glycosylation of recombinant protein in CHO cells
Authors: Burleigh, Susan C, Laar, Teun van de, Stroop, Corné J.M., Grunsven, Wout MJ van, O’Donoghue, Niaobh, Rudd, Pauline M., Davey, Gavin P.
PaperTrace element associated reduction of norleucine and norvaline accumulation during oxygen limitation in a recombinant Escherichia coli fermentation
Full title: Trace element associated reduction of norleucine and norvaline accumulation during oxygen limitation in a recombinant Escherichia coli fermentation
PaperSelective deposition of dietary α-lipoic acid in mitochondrial fraction and its synergistic effect with α-tocoperhol acetate on broiler meat oxidative stability.
Parveen, Rashida, Asghar, Ali, Anjum, Faqir M, Khan, Muhammad I, Arshad, Muhammad Sajid, Yasmeen, Ammara · 2013 · Lipids in health and disease · DOI
Full title: Selective deposition of dietary α-lipoic acid in mitochondrial fraction and its synergistic effect with α-tocoperhol acetate on broiler meat oxidative stability.
Authors: Parveen, Rashida, Asghar, Ali, Anjum, Faqir M, Khan, Muhammad I, Arshad, Muhammad Sajid, Yasmeen, Ammara
PaperEffect of anionic salt and highly fermentable carbohydrate supplementations on urine pH and on experimentally induced hypocalcaemia in cows.
Mellau, L S B, Jørgensen, R J, Bartlett, P C, Enemark, J M D, Hansen, A K · 2004 · Acta veterinaria Scandinavica · DOI
Full title: Effect of anionic salt and highly fermentable carbohydrate supplementations on urine pH and on experimentally induced hypocalcaemia in cows.
Authors: Mellau, L S B, Jørgensen, R J, Bartlett, P C, Enemark, J M D, Hansen, A K
PaperRumen-protected conjugated linoleic acid supplementation to dairy cows in late pregnancy and early lactation: effects on milk composition, milk yield, blood metabolites and gene expression in liver.
Sigl, Tanja, Schlamberger, Gregor, Kienberger, Hermine, Wiedemann, Steffi, Meyer, Heinrich Hd, Kaske, Martin · 2010 · Acta veterinaria Scandinavica · DOI
Full title: Rumen-protected conjugated linoleic acid supplementation to dairy cows in late pregnancy and early lactation: effects on milk composition, milk yield, blood metabolites and gene expression in liver.
Authors: Sigl, Tanja, Schlamberger, Gregor, Kienberger, Hermine, Wiedemann, Steffi, Meyer, Heinrich Hd, Kaske, Martin
PaperNon-stationary 13C metabolic flux analysis of Chinese hamster ovary cells in batch culture using extracellular labeling highlights metabolic reversibility and compartmentation
Nicolae, Averina, Wahrheit, Judith, Bahnemann, Janina, Zeng, An‐Ping, Heinzle, Elmar · 2014 · BMC Systems Biology · DOI
Full title: Non-stationary 13C metabolic flux analysis of Chinese hamster ovary cells in batch culture using extracellular labeling highlights metabolic reversibility and compartmentation
PaperCarnitine deficiency presenting with a decreased mental state in a patient with amyotrophic lateral sclerosis receiving long-term tube feeding: a case report.
Isse, Naohi, Miura, Yoh, Obata, Toshiyuki, Takahara, Noriko · 2013 · Journal of medical case reports · DOI
Full title: Carnitine deficiency presenting with a decreased mental state in a patient with amyotrophic lateral sclerosis receiving long-term tube feeding: a case report.
PaperAnalysis of glycolytic flux as a rapid screen to identify low lactate producing CHO cell lines with desirable monoclonal antibody yield and glycan profile
Legmann, Rachel, melito, Julie, Belzer, Ilana, Ferrick, David A. · 2011 · BMC Proceedings · DOI
Full title: Analysis of glycolytic flux as a rapid screen to identify low lactate producing CHO cell lines with desirable monoclonal antibody yield and glycan profile
Authors: Legmann, Rachel, melito, Julie, Belzer, Ilana, Ferrick, David A.
PaperFirst CpG island microarray for genome-wide analyses of DNA methylation in Chinese hamster ovary cells: new insights into the epigenetic answer to butyrate treatment
Anna Wippermann, S. Klausing, O. Rupp, T. Noll, R. Hoffrogge · 2013 · BMC Proceedings · DOI
Full title: First CpG island microarray for genome-wide analyses of DNA methylation in Chinese hamster ovary cells: new insights into the epigenetic answer to butyrate treatment
Authors: Anna Wippermann, S. Klausing, O. Rupp, T. Noll, R. Hoffrogge
PaperEffects of creep feeding and supplemental glutamine or glutamine plus glutamate (Aminogut) on pre- and post-weaning growth performance and intestinal health of piglets
R. Cabrera, J. Usry, Consuelo Arrellano, E. Nogueira, M. Kutschenko, A. Moeser, J. Odle · 2013 · Journal of Animal Science and Biotechnology · DOI
Full title: Effects of creep feeding and supplemental glutamine or glutamine plus glutamate (Aminogut) on pre- and post-weaning growth performance and intestinal health of piglets
Authors: R. Cabrera, J. Usry, Consuelo Arrellano, E. Nogueira, M. Kutschenko, A. Moeser, J. Odle
Year: 2013
Venue: Journal of Animal Science and Biotechnology
PaperGenerating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper(II)
York, Dona, Baker, Jeanne, Holder, Patrick G., Jones, Lesley, Drake, Penelope M., Barfield, Robyn M., Bleck, Gregory T., Rabuka, David · 2016 · BMC Biotechnology · DOI
Full title: Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper(II)
Authors: York, Dona, Baker, Jeanne, Holder, Patrick G., Jones, Lesley, Drake, Penelope M., Barfield, Robyn M., Bleck, Gregory T., Rabuka, David
PaperAbstracts from the 26th European Society for Animal Cell Technology Meeting - Cell culture technologies: bridging academia and industry to provide solutions for patients
Full title: Abstracts from the 26th European Society for Animal Cell Technology Meeting - Cell culture technologies: bridging academia and industry to provide solutions for patients
PaperInsights into the roles of exogenous phenylalanine and tyrosine in improving rapamycin production of Streptomyces rapamycinicus with transcriptome analysis
Full title: Insights into the roles of exogenous phenylalanine and tyrosine in improving rapamycin production of Streptomyces rapamycinicus with transcriptome analysis
PaperExperimental studies from shake flasks to 3 L stirred tank bioreactor of nutrients and oxygen supply conditions to improve the growth of the avian cell line DuckCelt®-T17.
Tingaud, Valentine, Bordes, Claire, Al Mouazen, Eyad, Cogné, Claudia, Bolzinger, Marie-Alexandrine, Lawton, Philippe · 2023 · Journal of biological engineering · DOI
Full title: Experimental studies from shake flasks to 3 L stirred tank bioreactor of nutrients and oxygen supply conditions to improve the growth of the avian cell line DuckCelt®-T17.
Authors: Tingaud, Valentine, Bordes, Claire, Al Mouazen, Eyad, Cogné, Claudia, Bolzinger, Marie-Alexandrine, Lawton, Philippe
PaperSystematically programmed adaptive evolution reveals potential role of carbon and nitrogen pathways during lipid accumulation in Chlamydomonas reinhardtii
Velmurugan, Natarajan, Sung, Minji, Yim, Sung Sun, Park, Min S., Yang, Ji Won, Jeong, Ki Jun · 2014 · Biotechnology for Biofuels · DOI
Full title: Systematically programmed adaptive evolution reveals potential role of carbon and nitrogen pathways during lipid accumulation in Chlamydomonas reinhardtii
Authors: Velmurugan, Natarajan, Sung, Minji, Yim, Sung Sun, Park, Min S., Yang, Ji Won, Jeong, Ki Jun
PaperHydrolyzed fish proteins reduced activation of caspase-3 in H2O2 induced oxidative stressed liver cells isolated from Atlantic salmon (Salmo salar)
M. Espe, E. Holen, J. He, F. Provan, L. Chen, K. B. Øysæd, J. Seliussen · 2015 · SpringerPlus · DOI
Full title: Hydrolyzed fish proteins reduced activation of caspase-3 in H2O2 induced oxidative stressed liver cells isolated from Atlantic salmon (Salmo salar)
Authors: M. Espe, E. Holen, J. He, F. Provan, L. Chen, K. B. Øysæd, J. Seliussen
PaperDietary supplementation with free methionine or methionine dipeptide mitigates intestinal oxidative stress induced by Eimeria spp. challenge in broiler chickens
A. Khatlab, A. P. Del Vesco, A. R. de Oliveira Neto, R. P. Fernandes, E. Gasparino · 2019 · Journal of Animal Science and Biotechnology · DOI
Full title: Dietary supplementation with free methionine or methionine dipeptide mitigates intestinal oxidative stress induced by Eimeria spp. challenge in broiler chickens
Authors: A. Khatlab, A. P. Del Vesco, A. R. de Oliveira Neto, R. P. Fernandes, E. Gasparino
Year: 2019
Venue: Journal of Animal Science and Biotechnology
PaperFast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment
Quek, Lake‐Ee, Liu, Menghan, Joshi, Sanket, Turner, Nigel · 2016 · Cancer & Metabolism · DOI
Full title: Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment
PaperResponses of CHO-DHFR cells to ratio of asparagine to glutamine in feed media: cell growth, antibody production, metabolic waste, glutamate, and energy metabolism
Full title: Responses of CHO-DHFR cells to ratio of asparagine to glutamine in feed media: cell growth, antibody production, metabolic waste, glutamate, and energy metabolism
PaperCell-culture growth conditions resulting in the oxidation of a recombinant antigen-binding fragment
Siddiquee, Khandaker, Zhao, Cheng, Stemler, Michelle, Zeck, Bill, Fishpaugh, Jeffrey R., Allen, Steven P. · 2019 · Bioresources and Bioprocessing · DOI
Full title: Cell-culture growth conditions resulting in the oxidation of a recombinant antigen-binding fragment
Authors: Siddiquee, Khandaker, Zhao, Cheng, Stemler, Michelle, Zeck, Bill, Fishpaugh, Jeffrey R., Allen, Steven P.
PaperBigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process
Morris, Caitlin, Polanco, Ashli, Yongky, Andrew, Xu, Jianlin, Huang, Zhuangrong, Zhao, Jia, McFarland, Kevin S., Park, Seo‐Young, Warrack, Bethanne M., Reily, Michael D., Borys, Michael, Li, Zheng Jian, Yoon, Seongkyu · 2020 · Bioresources and Bioprocessing · DOI
Full title: Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process
Authors: Morris, Caitlin, Polanco, Ashli, Yongky, Andrew, Xu, Jianlin, Huang, Zhuangrong, Zhao, Jia, McFarland, Kevin S., Park, Seo‐Young, Warrack, Bethanne M., Reily, Michael D., Borys, Michael, Li, Zheng Jian, Yoon, Seongkyu
PaperExperimental and In Silico Modelling Analyses of the Gene Expression Pathway for Recombinant Antibody and By-Product Production in NS0 Cell Lines
Mead, Emma J., Chiverton, Lesley M., Spurgeon, Sarah K., Martin, Elaine, Montague, G.A., Smales, C. Mark, Haar, Tobias von der · 2012 · PLoS ONE · DOI
Full title: Experimental and In Silico Modelling Analyses of the Gene Expression Pathway for Recombinant Antibody and By-Product Production in NS0 Cell Lines
Authors: Mead, Emma J., Chiverton, Lesley M., Spurgeon, Sarah K., Martin, Elaine, Montague, G.A., Smales, C. Mark, Haar, Tobias von der
PaperAvailability of Amino Acids Extends Chronological Lifespan by Suppressing Hyper-Acidification of the Environment in Saccharomyces cerevisiae
Y. Maruyama, T. Ito, H. Kodama, A. Matsuura · 2016 · PLoS ONE · DOI
Full title: Availability of Amino Acids Extends Chronological Lifespan by Suppressing Hyper-Acidification of the Environment in Saccharomyces cerevisiae
Authors: Y. Maruyama, T. Ito, H. Kodama, A. Matsuura
PaperComparison of secretory signal peptides for heterologous protein expression in microalgae: Expanding the secretion portfolio for Chlamydomonas reinhardtii
Molino, João Vitor Dutra, Carvalho, João Carlos Monteiro de, Mayfield, Stephen P. · 2018 · PLoS ONE · DOI
Full title: Comparison of secretory signal peptides for heterologous protein expression in microalgae: Expanding the secretion portfolio for Chlamydomonas reinhardtii
Authors: Molino, João Vitor Dutra, Carvalho, João Carlos Monteiro de, Mayfield, Stephen P.
PaperHigh glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells
Vergara, Mauricio, Torres, Mauro, Müller, Andrea, Avello, Verónica, Acevedo, Cristián, Berríos, Julio, Reyes, Juan G., Valdez‐Cruz, Norma A., Altamirano, Claudia · 2018 · PLoS ONE · DOI
Full title: High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells
PaperEvidence for co-translational misincorporation of non-canonical amino acid hydroxyproline in recombinant antibodies produced in Chinese Hamster Ovary (CHO) cell lines
Boddapati, Shanta, Gilmore, Jason M., Boone, Kyle, Bushey, John, Ross, Jonathan, Gfeller, Brian, McFee, William A., Rao, Romesh, Corrigan, Greg, Chen, Aaron, Clarke, Howard R. G., Valliere‐Douglass, John, Bhargava, Swapnil · 2020 · PLoS ONE · DOI
Full title: Evidence for co-translational misincorporation of non-canonical amino acid hydroxyproline in recombinant antibodies produced in Chinese Hamster Ovary (CHO) cell lines
Authors: Boddapati, Shanta, Gilmore, Jason M., Boone, Kyle, Bushey, John, Ross, Jonathan, Gfeller, Brian, McFee, William A., Rao, Romesh, Corrigan, Greg, Chen, Aaron, Clarke, Howard R. G., Valliere‐Douglass, John, Bhargava, Swapnil
PaperEnhanced recombinant protein production in CHO cell continuous cultures under growth-inhibiting conditions is associated with an arrested cell cycle in G1/G0 phase.
Avello, Verónica, Torres, Mauro, Vergara, Mauricio, Berrios, Julio, Valdez-Cruz, Norma A, Acevedo, Cristian, Molina Sampayo, Maria, Dickson, Alan J, Altamirano, Claudia · 2022 · PloS one · DOI
Full title: Enhanced recombinant protein production in CHO cell continuous cultures under growth-inhibiting conditions is associated with an arrested cell cycle in G1/G0 phase.
PaperSupplementing dairy feed by dicalcium phosphate and effect on dry matter intake, digestibility, milk composition, and blood mineral balances in crossbred dairy cows.
Wondater, Wondewsen Bekele, Ayanie, Tilaye Demissie · 2023 · PloS one · DOI
Full title: Supplementing dairy feed by dicalcium phosphate and effect on dry matter intake, digestibility, milk composition, and blood mineral balances in crossbred dairy cows.
PaperOptimization of transient protein production by chemically transfected CHO suspension cells
Elshereef, Abdalla Adel Sabry Abdelrazik Mohamed · 2018 · Institutional Repository of Leibniz Universität Hannover (Leibniz Universität Hannover) · DOI
Full title: Optimization of transient protein production by chemically transfected CHO suspension cells
PaperProteomics Profiling of Chimeric-Truncated Tissue Plasminogen activator Producing- Chinese Hamster Ovary Cells Cultivated in a Chemically Defined Medium Supplemented with Protein Hydrolysates
B. Azarian, Seyedeh Matin Sajedin, A. Azimi, M. Raigani, B. Vaziri, Fatemeh Davami · 2017 · Iranian Biomedical Journal · DOI
Full title: Proteomics Profiling of Chimeric-Truncated Tissue Plasminogen activator Producing- Chinese Hamster Ovary Cells Cultivated in a Chemically Defined Medium Supplemented with Protein Hydrolysates
Authors: B. Azarian, Seyedeh Matin Sajedin, A. Azimi, M. Raigani, B. Vaziri, Fatemeh Davami
PaperSupplementing D-Type and L-Type Methionine and Its Precursor Alters the Expression of mRNA, Proteins and Metabolites Involved in Milk Protein Synthesis and Energy Metabolism in Bovine Mammary Cells
S. Jeon, J. R. Conejos, Jungeun Kim, Min-Jeong Kim, Jeong-Eun Lee, B. S. Lee, Park Jinseung, J. Moon, Jae-Sung Lee, Hong-Gu Lee · 2018 · DOI
Full title: Supplementing D-Type and L-Type Methionine and Its Precursor Alters the Expression of mRNA, Proteins and Metabolites Involved in Milk Protein Synthesis and Energy Metabolism in Bovine Mammary Cells
Authors: S. Jeon, J. R. Conejos, Jungeun Kim, Min-Jeong Kim, Jeong-Eun Lee, B. S. Lee, Park Jinseung, J. Moon, Jae-Sung Lee, Hong-Gu Lee
PaperSupplementing L-Isoleucine Increases Medium Protein and Alters the Expression of Genes and Proteins Involved in Milk Protein Synthesis and Energy Metabolism in Bovine Mammary Cells
J. R. Conejos, Jae-Sung Lee, Jin-Seung Park, J. Moon, Hong-Gu Lee · 2019 · DOI
Full title: Supplementing L-Isoleucine Increases Medium Protein and Alters the Expression of Genes and Proteins Involved in Milk Protein Synthesis and Energy Metabolism in Bovine Mammary Cells
Authors: J. R. Conejos, Jae-Sung Lee, Jin-Seung Park, J. Moon, Hong-Gu Lee
PaperDeciphering Metabolic Pathways in High Seeding Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective
Full title: Deciphering Metabolic Pathways in High Seeding Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective
PaperEffect of dietary tryptophan supplementation on growth, body composition and digestive enzymes activity of juvenile silver pompano Trachinotus blochii (Lacepede, 1801)
Meenu Devassykutty, Boby Ignatius, V. P., S. Ebeneezar, P. Sawant, B. A. M., E. Varghese, S. P., Sajina K.A · 2022 · Indian Journal of Fisheries · DOI
Full title: Effect of dietary tryptophan supplementation on growth, body composition and digestive enzymes activity of juvenile silver pompano Trachinotus blochii (Lacepede, 1801)
Authors: Meenu Devassykutty, Boby Ignatius, V. P., S. Ebeneezar, P. Sawant, B. A. M., E. Varghese, S. P., Sajina K.A
PaperDietary Prebiotics and Probiotics Influence the Growth Performance, Feed Utilisation, and Body Indices of Snakehead (Channa striata) Fingerlings.
Munir, Mohammad Bodrul, Hashim, Roshada, Abdul Manaf, Mohammad Suhaimee, Nor, Siti Azizah Mohd · 2016 · Tropical life sciences research · DOI
Full title: Dietary Prebiotics and Probiotics Influence the Growth Performance, Feed Utilisation, and Body Indices of Snakehead (Channa striata) Fingerlings.
Authors: Munir, Mohammad Bodrul, Hashim, Roshada, Abdul Manaf, Mohammad Suhaimee, Nor, Siti Azizah Mohd
Full title: The Epigenetic Regulation of Blinatumomab Gene Expression: Tumor Cell-dependent T cell Response against Lymphoma Cells and Cytotoxic Activity.
PaperDietary Taurine Improves The Growth Performance, Health Status and Liver Histopathology of Meagre (Argyrosomus Regius) Fed A Reduced Fish Meal Diet
Derya Güroy, Onur Karadal, Betül Güroy, Y. Emre, N. Emre, Durali Eraslan, F. B. Yalım, Serhan Mantoğlu, Abdullah Demir · 2024 · Annals of Animal Science · DOI
Full title: Dietary Taurine Improves The Growth Performance, Health Status and Liver Histopathology of Meagre (Argyrosomus Regius) Fed A Reduced Fish Meal Diet
Authors: Derya Güroy, Onur Karadal, Betül Güroy, Y. Emre, N. Emre, Durali Eraslan, F. B. Yalım, Serhan Mantoğlu, Abdullah Demir
PaperOuantitative Proteomic Analysis of Cellular Responses to a Designed Amino Acid Feed in a Monoclonal Antibody Producing Chinese Hamster Ovary Cell Line
Full title: Ouantitative Proteomic Analysis of Cellular Responses to a Designed Amino Acid Feed in a Monoclonal Antibody Producing Chinese Hamster Ovary Cell Line
PaperEffects of dietary resveratrol supplementation on digestive enzymes activities and serum biochemistry of rainbow trout (Oncorhynchus mykiss).
Afzali-Kordmahalleh, Alireza, Meshkini, Saeid · 2023 · Veterinary research forum : an international quarterly journal · DOI
Full title: Effects of dietary resveratrol supplementation on digestive enzymes activities and serum biochemistry of rainbow trout (Oncorhynchus mykiss).
PaperBiljni proteinski hidrolizati kao dodatak medijima za uzgoj životinjskih stanica
Srček, Višnja Gaurina, Ursić, Tino, Logarušić, Marijan, Radošević, Kristina, Slivac, Igor · 2022 · Hrvatski časopis za prehrambenu tehnologiju biotehnologiju i nutricionizam · DOI
Full title: Biljni proteinski hidrolizati kao dodatak medijima za uzgoj životinjskih stanica
PaperModel Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments
Bayer, Benjamin, Duerkop, Mark, Striedner, Gerald, Sissolak, Bernhard · 2021 · Frontiers in Bioengineering and Biotechnology · DOI
Full title: Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments
Authors: Bayer, Benjamin, Duerkop, Mark, Striedner, Gerald, Sissolak, Bernhard
Year: 2021
Venue: Frontiers in Bioengineering and Biotechnology
PaperBoosting Productivity for Advanced Biomanufacturing by Re-Using Viable Cells
Reger, Lucas Nik, Saballus, Martin, Matuszczyk, Jens, Kampmann, Markus, Wijffels, René H., Martens, Dirk E., Niemann, Julia · 2023 · Frontiers in Bioengineering and Biotechnology · DOI
Full title: Boosting Productivity for Advanced Biomanufacturing by Re-Using Viable Cells
Authors: Reger, Lucas Nik, Saballus, Martin, Matuszczyk, Jens, Kampmann, Markus, Wijffels, René H., Martens, Dirk E., Niemann, Julia
Year: 2023
Venue: Frontiers in Bioengineering and Biotechnology
PaperSodium acetate increases the productivity of HEK293 cells expressing the ECD-Her1 protein in batch cultures: experimental results and metabolic flux analysis
Pérez-Fernández, Bárbara Ariane, Calzadilla, Lisandra, Bena, Chiara Enrico, Giudice, Marco Del, Bosia, Carla, Boggiano-Ayo, Tammy, Mulet, Roberto · 2024 · Frontiers in Bioengineering and Biotechnology · DOI
Full title: Sodium acetate increases the productivity of HEK293 cells expressing the ECD-Her1 protein in batch cultures: experimental results and metabolic flux analysis
Authors: Pérez-Fernández, Bárbara Ariane, Calzadilla, Lisandra, Bena, Chiara Enrico, Giudice, Marco Del, Bosia, Carla, Boggiano-Ayo, Tammy, Mulet, Roberto
Year: 2024
Venue: Frontiers in Bioengineering and Biotechnology
PaperGenetics, environmental stress, and amino acid supplementation affect lactational performance via mTOR signaling pathway in bovine mammary epithelial cells
Bin Li, M. Khan, I. Khan, Qudrat Ullah, Zhuoma Cisang, N. Zhang, Dan Wu, Bingjian Huang, Yulin Ma, Adnan Khan, Nan Jiang, Muhammad Zahoor · 2023 · Frontiers in Genetics · DOI
Full title: Genetics, environmental stress, and amino acid supplementation affect lactational performance via mTOR signaling pathway in bovine mammary epithelial cells
Authors: Bin Li, M. Khan, I. Khan, Qudrat Ullah, Zhuoma Cisang, N. Zhang, Dan Wu, Bingjian Huang, Yulin Ma, Adnan Khan, Nan Jiang, Muhammad Zahoor
PaperMetabolic analyses elucidate non-trivial gene targets for amplifying dihydroartemisinic acid production in yeast
Misra, Ashish, Conway, Matthew F., Johnnie, Joseph, Qureshi, Tabish M., Lige, Bao, Derrick, Anne M., Agbo, Eddy C., Sriram, Ganesh · 2013 · Frontiers in Microbiology · DOI
Full title: Metabolic analyses elucidate non-trivial gene targets for amplifying dihydroartemisinic acid production in yeast
Authors: Misra, Ashish, Conway, Matthew F., Johnnie, Joseph, Qureshi, Tabish M., Lige, Bao, Derrick, Anne M., Agbo, Eddy C., Sriram, Ganesh
PaperChanges in the Intestine Microbial, Digestive, and Immune-Related Genes of Litopenaeus vannamei in Response to Dietary Probiotic Clostridium butyricum Supplementation
Full title: Changes in the Intestine Microbial, Digestive, and Immune-Related Genes of Litopenaeus vannamei in Response to Dietary Probiotic Clostridium butyricum Supplementation
PaperDietary Aroclor 1254-Induced Toxicity on Antioxidant Capacity, Immunity and Energy Metabolism in Chinese Mitten Crab Eriocheir sinensis: Amelioration by Vitamin A.
Feng, Dexiang, Wang, Xiaodan, Li, Erchao, Bu, Xianyong, Qiao, Fang, Qin, Jianguang, Chen, Liqiao · 2019 · Frontiers in physiology · DOI
Full title: Dietary Aroclor 1254-Induced Toxicity on Antioxidant Capacity, Immunity and Energy Metabolism in Chinese Mitten Crab Eriocheir sinensis: Amelioration by Vitamin A.
PaperEffects of Dietary Inclusion of Shrimp Paste on Growth Performance, Digestive Enzymes Activities, Antioxidant and Immunological Status and Intestinal Morphology of Hybrid Snakehead (Channa maculata ♀ × Channa argus ♂).
Fang, Haohang, Xie, Jiajun, Liao, Shiyu, Guo, Tianyu, Xie, Shiwei, Liu, Yongjian, Tian, Lixia, Niu, Jin · 2019 · Frontiers in physiology · DOI
Full title: Effects of Dietary Inclusion of Shrimp Paste on Growth Performance, Digestive Enzymes Activities, Antioxidant and Immunological Status and Intestinal Morphology of Hybrid Snakehead (Channa maculata ♀ × Channa argus ♂).
PaperComparative study on the effects of crystalline L-methionine and methionine hydroxy analogue calcium supplementations in the diet of juvenile Pacific white shrimp (Litopenaeus vannamei)
Full title: Comparative study on the effects of crystalline L-methionine and methionine hydroxy analogue calcium supplementations in the diet of juvenile Pacific white shrimp (Litopenaeus vannamei)
PaperDietary Enteromorpha Polysaccharides Supplementation Improves Breast Muscle Yield and Is Associated With Modification of mRNA Transcriptome in Broiler Chickens.
Full title: Dietary Enteromorpha Polysaccharides Supplementation Improves Breast Muscle Yield and Is Associated With Modification of mRNA Transcriptome in Broiler Chickens.
PaperBacillus subtilis Produces Amino Acids to Stimulate Protein Synthesis in Ruminal Tissue Explants via the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta–Serine/Threonine Kinase–Mammalian Target of Rapamycin Complex 1 Pathway
Qiuju Wang, Yulong Ren, Yizhe Cui, Bingnan Gao, Hao Zhang, Q. Jiang, J. Loor, Z. Deng, Chuang Xu · 2022 · Frontiers in Veterinary Science · DOI
Full title: Bacillus subtilis Produces Amino Acids to Stimulate Protein Synthesis in Ruminal Tissue Explants via the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta–Serine/Threonine Kinase–Mammalian Target of Rapamycin Complex 1 Pathway
Authors: Qiuju Wang, Yulong Ren, Yizhe Cui, Bingnan Gao, Hao Zhang, Q. Jiang, J. Loor, Z. Deng, Chuang Xu
PaperVarying the ratio of Lys: Met through enhancing methionine supplementation improved milk secretion ability through regulating the mRNA expression in bovine mammary epithelial cells under heat stress
Lin Fu, Yinjie You, Yu Zeng, Qifan Ran, Yan Zhou, Rui Long, Heng Yang, Juncai Chen, Juan J. Loor, Gaofu Wang, Li Zhang, Xianwen Dong · 2024 · Frontiers in Veterinary Science · DOI
Full title: Varying the ratio of Lys: Met through enhancing methionine supplementation improved milk secretion ability through regulating the mRNA expression in bovine mammary epithelial cells under heat stress
Authors: Lin Fu, Yinjie You, Yu Zeng, Qifan Ran, Yan Zhou, Rui Long, Heng Yang, Juncai Chen, Juan J. Loor, Gaofu Wang, Li Zhang, Xianwen Dong
PaperHigh-Level Production of scFv-Fc Antibody Using an Artificial Promoter System with Transcriptional Positive Feedback Loop of Transactivator in CHO Cells
Full title: High-Level Production of scFv-Fc Antibody Using an Artificial Promoter System with Transcriptional Positive Feedback Loop of Transactivator in CHO Cells
PaperDynamics of Amino Acid Metabolism, Gene Expression, and Circulomics in a Recombinant Chinese Hamster Ovary Cell Line Adapted to Moderate and High Levels of Extracellular Lactate
Chitwood, Dylan G., Uy, Lisa, Fu, Wanfang, Klaubert, Stephanie R., Harcum, Sarah W., Saski, Christopher · 2023 · Genes · DOI
Full title: Dynamics of Amino Acid Metabolism, Gene Expression, and Circulomics in a Recombinant Chinese Hamster Ovary Cell Line Adapted to Moderate and High Levels of Extracellular Lactate
Authors: Chitwood, Dylan G., Uy, Lisa, Fu, Wanfang, Klaubert, Stephanie R., Harcum, Sarah W., Saski, Christopher
PaperTowards Controlling the Glycoform: A Model Framework Linking Extracellular Metabolites to Antibody Glycosylation
Jedrzejewski, Philip, Val, Ioscani Jiménez del, Constantinou, Antony, Dell, Anne, Haslam, Stuart M., Polizzi, Karen M., Kontoravdi, Cleo · 2014 · International Journal of Molecular Sciences · DOI
Full title: Towards Controlling the Glycoform: A Model Framework Linking Extracellular Metabolites to Antibody Glycosylation
Authors: Jedrzejewski, Philip, Val, Ioscani Jiménez del, Constantinou, Antony, Dell, Anne, Haslam, Stuart M., Polizzi, Karen M., Kontoravdi, Cleo
Year: 2014
Venue: International Journal of Molecular Sciences
PaperIdentification of Cell Culture Factors Influencing Afucosylation Levels in Monoclonal Antibodies by Partial Least-Squares Regression and Variable Importance Metrics
Rish, Adam J., Huang, Zhuangrong, Siddiquee, Khandaker, Xu, Jianlin, Anderson, Carl A., Borys, Michael, Khetan, Anurag · 2023 · Processes · DOI
Full title: Identification of Cell Culture Factors Influencing Afucosylation Levels in Monoclonal Antibodies by Partial Least-Squares Regression and Variable Importance Metrics
Authors: Rish, Adam J., Huang, Zhuangrong, Siddiquee, Khandaker, Xu, Jianlin, Anderson, Carl A., Borys, Michael, Khetan, Anurag
Full title: Enhanced Production of Anti-PD1 Antibody in CHO Cells through Transient Co-Transfection with Anti-Apoptotic Gene Bcl-xL Combined with Rapamycin
PaperEffect of Sialic Acid on Mammalian Cell Culture and Protein Expression: A Potential Productivity Enhancer for Biopharmaceutical Cell Culture Processes
Full title: Effect of Sialic Acid on Mammalian Cell Culture and Protein Expression: A Potential Productivity Enhancer for Biopharmaceutical Cell Culture Processes
PaperOptimizing the Production of gp145, an HIV-1 Envelope Glycoprotein Vaccine Candidate and Its Encapsulation in Guanosine Microparticles
Akamine, Pearl, González‐Feliciano, José A., Almodóvar, Ruth, Morell, Gloriner, Sandoval, Javier, Capó-Vélez, Coral M., Delgado‐Vélez, Manuel, Prieto-Costas, Luis A., Madera, Bismark, Eichinger, Daniel, Pino, Ignacio, Rivera, José H., Ortiz-Ubarri, José, Rivera, José M., Baerga‐Ortiz, Abel, Lasalde‐Dominicci, José A. · 2023 · Vaccines · DOI
Full title: Optimizing the Production of gp145, an HIV-1 Envelope Glycoprotein Vaccine Candidate and Its Encapsulation in Guanosine Microparticles
Authors: Akamine, Pearl, González‐Feliciano, José A., Almodóvar, Ruth, Morell, Gloriner, Sandoval, Javier, Capó-Vélez, Coral M., Delgado‐Vélez, Manuel, Prieto-Costas, Luis A., Madera, Bismark, Eichinger, Daniel, Pino, Ignacio, Rivera, José H., Ortiz-Ubarri, José, Rivera, José M., Baerga‐Ortiz, Abel, Lasalde‐Dominicci, José A.
PaperIs the development of low-cost media one of the greatest challenges to produce cultivated meat on an industrial scale?
Soccol, Carlos Ricardo, Karp, Susan Grace, Letti, Luiz Alberto Júnior, Biagini, Giuliana, Balla, Gabriel, Boligon, Ana Paula, Candelário, João Pedro Mânica, Faria, Thiago Feliciano, Mattos, Patrícia Beatriz Gruening de, Piazenski, Igor Negreiros, Raymundo, L.C., Valeixo, Daniel Augusto Ribeiro Rolim, Thomaz‐Soccol, Vanete · 2022 · Biotechnology Research and Innovation · DOI
Full title: Is the development of low-cost media one of the greatest challenges to produce cultivated meat on an industrial scale?
Authors: Soccol, Carlos Ricardo, Karp, Susan Grace, Letti, Luiz Alberto Júnior, Biagini, Giuliana, Balla, Gabriel, Boligon, Ana Paula, Candelário, João Pedro Mânica, Faria, Thiago Feliciano, Mattos, Patrícia Beatriz Gruening de, Piazenski, Igor Negreiros, Raymundo, L.C., Valeixo, Daniel Augusto Ribeiro Rolim, Thomaz‐Soccol, Vanete
PaperEffects of dandelion (Taraxacum sp.,) supplements on lactation performance, antioxidative activity, and plasma metabolome in primiparous dairy cows
Yan Li, Jie Mei, Jiaqi Wang, Hongyun Liu · 2022 · Animal bioscience · DOI
Full title: Effects of dandelion (Taraxacum sp.,) supplements on lactation performance, antioxidative activity, and plasma metabolome in primiparous dairy cows
PaperEffect of different levels of protein concentrates supplementation on the growth performance, plasma amino acids profile and mTOR cascade genes expression in early-weaned yak calves.
Peng, Q H, Khan, N A, Xue, B, Yan, T H, Wang, Z S · 2018 · Asian-Australasian journal of animal sciences · DOI
Full title: Effect of different levels of protein concentrates supplementation on the growth performance, plasma amino acids profile and mTOR cascade genes expression in early-weaned yak calves.
Authors: Peng, Q H, Khan, N A, Xue, B, Yan, T H, Wang, Z S
Year: 2018
Venue: Asian-Australasian journal of animal sciences
PaperMilk yield and immune response of periparturient and early lactation friesian cows fed diets supplemented with a high level of amino-acid chelated chromium
S. Terramoccia, S. Bartocci, E. Lillini · 2005 · Anim. Sci. · DOI
Full title: Milk yield and immune response of periparturient and early lactation friesian cows fed diets supplemented with a high level of amino-acid chelated chromium
PaperUse of δ-Aminolevulinic Acid in Swine Diet: Effect on Growth Performance, Behavioral Characteristics and Hematological/Immune Status in Nursery Pigs
R. D. Mateo, J. Morrow, J. Dailey, F. Ji, S. Kim · 2005 · Anim. Sci. · DOI
Full title: Use of δ-Aminolevulinic Acid in Swine Diet: Effect on Growth Performance, Behavioral Characteristics and Hematological/Immune Status in Nursery Pigs
Authors: R. D. Mateo, J. Morrow, J. Dailey, F. Ji, S. Kim
PaperEffect of Essential and Nonessential Amino Acids in North Carolina State University (NCSU)-23 Medium on Development of Porcine In vitro Fertilized Embryos
M. A. Hashem, D. Bhandari, M. Hossein, Jeong Yeon Woo, Kim Sue, Kim Ji-Hye, Koo Ok-Jae, Park Seon Mi, Lee Eu Gine, Park Sun Woo, S. Kang, Byeong-chun Lee · 2007 · DOI
Full title: Effect of Essential and Nonessential Amino Acids in North Carolina State University (NCSU)-23 Medium on Development of Porcine In vitro Fertilized Embryos
Authors: M. A. Hashem, D. Bhandari, M. Hossein, Jeong Yeon Woo, Kim Sue, Kim Ji-Hye, Koo Ok-Jae, Park Seon Mi, Lee Eu Gine, Park Sun Woo, S. Kang, Byeong-chun Lee
PaperEffects of Dietary Supplementation of Barodon, an Anionic Alkali Mineral Complex, on Growth Performance, Feed Utilization, Innate Immunity, Goblet Cell and Digestibility in Olive Flounder (Paralichthys olivaceus).
Shin, Chang-Hoon, Cha, Ji-Hoon, Rahimnejad, Samad, Jeong, Joon-Bum, Yoo, Byung-Woo, Lee, Bo-Kyeun, Ahn, Hyung-Jin, Choi, Soo-Il, Choi, Yun-Jeong, Park, Yong-Ho, Kim, Jeong-Dae, Lee, Kyeong-Jun · 2014 · Asian-Australasian journal of animal sciences · DOI
Full title: Effects of Dietary Supplementation of Barodon, an Anionic Alkali Mineral Complex, on Growth Performance, Feed Utilization, Innate Immunity, Goblet Cell and Digestibility in Olive Flounder (Paralichthys olivaceus).
PaperEffect of Dietary Supplementation of Blood Meal and Additional Magnesium on Carnosine and Anserine Concentrations of Pig Muscles.
Park, Se Won, Kim, Chan Ho, Kim, Jong Woong, Shin, Hye Seong, Paik, In Kee, Kil, Dong Yong · 2014 · Korean journal for food science of animal resources · DOI
Full title: Effect of Dietary Supplementation of Blood Meal and Additional Magnesium on Carnosine and Anserine Concentrations of Pig Muscles.
Authors: Park, Se Won, Kim, Chan Ho, Kim, Jong Woong, Shin, Hye Seong, Paik, In Kee, Kil, Dong Yong
Year: 2014
Venue: Korean journal for food science of animal resources
PaperEffects of Peptone Supplementation in Different Culture Media on Growth, Metabolic Pathway and Productivity of CHO DG44 Cells; a New Insight into Amino Acid Profiles.
Full title: Effects of Peptone Supplementation in Different Culture Media on Growth, Metabolic Pathway and Productivity of CHO DG44 Cells; a New Insight into Amino Acid Profiles.
PaperMarked variations in gut microbiota and some innate immune responses of fresh water crayfish, marron (Cherax cainii, Austin 2002) fed dietary supplementation of Clostridium butyricum.
Foysal, Md Javed, Nguyen, Thi Thu Thuy, Chaklader, Md Reaz, Siddik, Muhammad A B, Tay, Chin-Yen, Fotedar, Ravi, Gupta, Sanjay Kumar · 2019 · PeerJ · DOI
Full title: Marked variations in gut microbiota and some innate immune responses of fresh water crayfish, marron (Cherax cainii, Austin 2002) fed dietary supplementation of Clostridium butyricum.
PaperA genome-scale metabolic network model synergizes with statistical learning to predict amino acid concentrations in Chinese Hamster Ovary cell cultures
Song-Min Schinn, Carly Morrison, Wei Wei, Lin Zhang, Nathan E. Lewis · 2020 · bioRxiv · DOI
Full title: A genome-scale metabolic network model synergizes with statistical learning to predict amino acid concentrations in Chinese Hamster Ovary cell cultures
Authors: Song-Min Schinn, Carly Morrison, Wei Wei, Lin Zhang, Nathan E. Lewis
PaperLevan Production in Shake Flask and Fermenter Influence of Feeding Strategy on Levan Yield and Molecular Weight Distribution
Bhuvaneshwari Veerapandian, Saravanan Ramiah Shanmugam, Srividhya Krishnan, Subramaniyasharma Sivaraman, M. Sriariyanun, P. Venkatachalam · 2023 · E3S Web of Conferences · DOI
Full title: Levan Production in Shake Flask and Fermenter Influence of Feeding Strategy on Levan Yield and Molecular Weight Distribution
Authors: Bhuvaneshwari Veerapandian, Saravanan Ramiah Shanmugam, Srividhya Krishnan, Subramaniyasharma Sivaraman, M. Sriariyanun, P. Venkatachalam
PaperImmunogenic and Protective Properties of Recombinant Hemagglutinin of Influenza A (H5N8) Virus
N. Rudometova, A. A. Fando, L. A. Kisakova, D. N. Kisakov, M. B. Borgoyakova, V. R. Litvinova, V. A. Yakovlev, E. V. Tigeeva, Danil I. Vahitov, S. V. Sharabrin, D. Shcherbakov, V. I. Evseenko, K. I. Ivanova, A. Gudymo, T. Ilyicheva, V. Marchenko, A. Ilyichev, A. P. Rudometov, L. Karpenko · 2024 · Vaccines · DOI
Full title: Immunogenic and Protective Properties of Recombinant Hemagglutinin of Influenza A (H5N8) Virus
Authors: N. Rudometova, A. A. Fando, L. A. Kisakova, D. N. Kisakov, M. B. Borgoyakova, V. R. Litvinova, V. A. Yakovlev, E. V. Tigeeva, Danil I. Vahitov, S. V. Sharabrin, D. Shcherbakov, V. I. Evseenko, K. I. Ivanova, A. Gudymo, T. Ilyicheva, V. Marchenko, A. Ilyichev, A. P. Rudometov, L. Karpenko
ThesisInfluência do butirato de sódio, da cicloheximida e do cloreto de manganês na produtividade, glicosilação e propriedades biológicas da tireotrofina humana derivada de CHO
Ribela, Maria Teresa de Carvalho Pinto · 2014 · Theses · DOI
Full title: Influência do butirato de sódio, da cicloheximida e do cloreto de manganês na produtividade, glicosilação e propriedades biológicas da tireotrofina humana derivada de CHO
ThesisEffects of human growth factors TGF-β1 and PDGF-BB stable heterologous expression and exogenous addition over the growth performance of CHO and HEK cell lines in adherent culture
Full title: Effects of human growth factors TGF-β1 and PDGF-BB stable heterologous expression and exogenous addition over the growth performance of CHO and HEK cell lines in adherent culture
ThesisThe Effect of Dietary Nucleotide Supplementation on Growth and Feed Efficiency of Rainbow Trout (Oncorhynchus mykiss) Fed Fish Meal-Free and Animal Protein-Free Diets
Full title: The Effect of Dietary Nucleotide Supplementation on Growth and Feed Efficiency of Rainbow Trout (Oncorhynchus mykiss) Fed Fish Meal-Free and Animal Protein-Free Diets
ThesisUsing simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe et al. · 2016 · Theses · DOI
Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
Authors: López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe; Carrillo-Cocom, Leydi Maribel; Rocha-Pizaña, María del Refugio; Alvarez, Mario Moises
ThesisStrategies to improve protein production of Chinese hamster ovary cell lines and genome annotation under the guidance of high throughput omics technology
Full title: Strategies to improve protein production of Chinese hamster ovary cell lines and genome annotation under the guidance of high throughput omics technology
Full title: An investigation of the effects of additives on Chinese Hamster ovary cells : the optimization of a quantitative technique for mass screening /
ThesisRational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions
Backliwal, G; Hildinger, M; Chenuet, S et al. · 2009 · Theses · DOI
Full title: Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions
Authors: Backliwal, G; Hildinger, M; Chenuet, S; Wulhfard, S; De Jesus, M; Wurm, FM
ThesisProcess optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand
Full title: Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand
ThesisEnhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium
Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Òdena, Andreu et al. · 2023 · Theses · DOI
Full title: Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium
Authors: Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Òdena, Andreu; Karottki, Karen Julie la Cour; Kim, Che Lin; Hefzi, Hooman; Lee, Gyun Min; Faustrup Kildegaard, Helene; Nielsen, Lars K.; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lewis, Nathan E.
ThesisAssessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing
Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP] et al. · 2019 · Theses · DOI
Full title: Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing
Authors: Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP]; Deffune, Elenice; Suazo, Cláudio Alberto Torres
ThesisSolving the foetal bovine serum problem for cultivated meat – investigation of methods, adult bovine blood products, and first isolation and cultivation of cervine muscle cells in a defined system
Full title: Solving the foetal bovine serum problem for cultivated meat – investigation of methods, adult bovine blood products, and first isolation and cultivation of cervine muscle cells in a defined system
ThesisSobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes
Full title: Sobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes
Full title: Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms
ThesisEnhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium
Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Òdena, Andreu et al. · 2023 · Technical University of Denmark (DTU) · DOI
Full title: Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium
Authors: Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Òdena, Andreu; Karottki, Karen Julie la Cour; Kim, Che Lin; Hefzi, Hooman; Lee, Gyun Min; Faustrup Kildegaard, Helene; Nielsen, Lars K.; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lewis, Nathan E.
ThesisAssessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing
Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP] et al. · 2019 · Universidade Estadual Paulista (UNESP) · DOI
Full title: Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing
Authors: Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP]; Deffune, Elenice; Suazo, Cláudio Alberto Torres
ThesisComputer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.
Traustason, Bergthor; Cheeks, Matthew; Dikicioglu, Duygu · 2020 · University of Cambridge · DOI
Full title: Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.
ThesisUsing simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe et al. · 2016 · Massachusetts Institute of Technology (MIT) · DOI
Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
Authors: López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe; Carrillo-Cocom, Leydi Maribel; Rocha-Pizaña, María del Refugio; Alvarez, Mario Moises
Year: 2016
Venue: Massachusetts Institute of Technology (MIT)
ThesisInfluência do butirato de sódio, da cicloheximida e do cloreto de manganês na produtividade, glicosilação e propriedades biológicas da tireotrofina humana derivada de CHO
Ribela, Maria Teresa de Carvalho Pinto · 2014 · Universidade de São Paulo – USP Digital Library · DOI
Full title: Influência do butirato de sódio, da cicloheximida e do cloreto de manganês na produtividade, glicosilação e propriedades biológicas da tireotrofina humana derivada de CHO
Authors: Ribela, Maria Teresa de Carvalho Pinto
Year: 2014
Venue: Universidade de São Paulo – USP Digital Library
ThesisRational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions
Backliwal, G; Hildinger, M; Chenuet, S et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions
Authors: Backliwal, G; Hildinger, M; Chenuet, S; Wulhfard, S; De Jesus, M; Wurm, FM
Year: 2009
Venue: École polytechnique fédérale de Lausanne (EPFL)
ThesisProcess optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand
Full title: Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand
ThesisEffects of human growth factors TGF-β1 and PDGF-BB stable heterologous expression and exogenous addition over the growth performance of CHO and HEK cell lines in adherent culture
Tonso, Aldo · 2022 · Universidade de São Paulo – USP Digital Library · DOI
Full title: Effects of human growth factors TGF-β1 and PDGF-BB stable heterologous expression and exogenous addition over the growth performance of CHO and HEK cell lines in adherent culture
Authors: Tonso, Aldo
Year: 2022
Venue: Universidade de São Paulo – USP Digital Library
ThesisSobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes
Bulté Ocaña, Dubhe Beatriz · 2021 · Universidad Nacional Autónoma de México (UNAM) · DOI
Full title: Sobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes
Authors: Bulté Ocaña, Dubhe Beatriz
Year: 2021
Venue: Universidad Nacional Autónoma de México (UNAM)
ThesisSolving the foetal bovine serum problem for cultivated meat – investigation of methods, adult bovine blood products, and first isolation and cultivation of cervine muscle cells in a defined system
Steinmetz, Kai · 2025 · University of Auckland · DOI
Full title: Solving the foetal bovine serum problem for cultivated meat – investigation of methods, adult bovine blood products, and first isolation and cultivation of cervine muscle cells in a defined system
ThesisIdentification of cellular changes associated with increased production of human follicle stimulating hormone in a recombinant Chinese hamster ovary cell line
Full title: Identification of cellular changes associated with increased production of human follicle stimulating hormone in a recombinant Chinese hamster ovary cell line
ThesisStrategies to improve protein production of Chinese hamster ovary cell lines and genome annotation under the guidance of high throughput omics technology
Li, Shangzhong · 2019 · University of California, San Diego (UCSD) · DOI
Full title: Strategies to improve protein production of Chinese hamster ovary cell lines and genome annotation under the guidance of high throughput omics technology
ThesisAn investigation of the effects of additives on Chinese Hamster ovary cells : the optimization of a quantitative technique for mass screening /
Younger, Angela Camille · 1999 · OhioLINK Electronic Theses and Dissertations · DOI
Full title: An investigation of the effects of additives on Chinese Hamster ovary cells : the optimization of a quantitative technique for mass screening /
Authors: Younger, Angela Camille
Year: 1999
Venue: OhioLINK Electronic Theses and Dissertations
PaperMethylthioadenosine (MTA) boosts cell‐specific productivities of Chinese hamster ovary cultures: dosage effects on proliferation, cell cycle and gene expression
Verhagen, Natascha, Zieringer, Julia, Takors, Ralf · 2020 · FEBS Open Bio · DOI
Full title: Methylthioadenosine (MTA) boosts cell‐specific productivities of Chinese hamster ovary cultures: dosage effects on proliferation, cell cycle and gene expression
Paper<i>Pichia pastoris</i> secretes recombinant proteins less efficiently than Chinese hamster ovary cells but allows higher space‐time yields for less complex proteins
Full title: <i>Pichia pastoris</i> secretes recombinant proteins less efficiently than Chinese hamster ovary cells but allows higher space‐time yields for less complex proteins
PaperMetabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness
Sellick, Christopher, Croxford, Alexandra S., Maqsood, Arfa, Stephens, Gill, Westerhoff, Hans V., Goodacre, Royston, Dickson, Alan J. · 2015 · Biotechnology Journal · DOI
Full title: Metabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness
Authors: Sellick, Christopher, Croxford, Alexandra S., Maqsood, Arfa, Stephens, Gill, Westerhoff, Hans V., Goodacre, Royston, Dickson, Alan J.
PaperReal‐time monitoring of specific oxygen uptake rates of embryonic stem cells in a microfluidic cell culture device
Super, Alexandre, Jaccard, Nicolas, Marques, Marco P. C., Macown, Rhys J., Griffin, Lewis D., Veraitch, Farlan, Szita, Nicolas · 2016 · Biotechnology Journal · DOI
Full title: Real‐time monitoring of specific oxygen uptake rates of embryonic stem cells in a microfluidic cell culture device
Authors: Super, Alexandre, Jaccard, Nicolas, Marques, Marco P. C., Macown, Rhys J., Griffin, Lewis D., Veraitch, Farlan, Szita, Nicolas
PaperMulti-Omics Reveals Impact of Cysteine Feed Concentration and Resulting Redox Imbalance on Cellular Energy Metabolism and Specific Productivity in CHO Cell Bioprocessing.
Ali, Amr S, Chen, Rachel, Raju, Ravali, Kshirsagar, Rashmi, Gilbert, Alan, Zang, Li, Karger, Barry L, Ivanov, Alexander R · 2020 · Biotechnology journal · DOI
Full title: Multi-Omics Reveals Impact of Cysteine Feed Concentration and Resulting Redox Imbalance on Cellular Energy Metabolism and Specific Productivity in CHO Cell Bioprocessing.
Authors: Ali, Amr S, Chen, Rachel, Raju, Ravali, Kshirsagar, Rashmi, Gilbert, Alan, Zang, Li, Karger, Barry L, Ivanov, Alexander R
PaperContinuous optical in‐line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency while maintaining darbepoetin alfa product quality
Full title: Continuous optical in‐line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency while maintaining darbepoetin alfa product quality
PaperReal‐time amino acid and glucose monitoring system for the automatic control of nutrient feeding in CHO cell culture using Raman spectroscopy
Júlia Domján, Eszter Pantea, M. Gyürkés, L. Madarász, Dóra Kozák, A. Farkas, B. Horváth, Zsuzsa Benkő, Z. Nagy, G. Marosi, E. Hirsch · 2022 · Biotechnology Journal · DOI
Full title: Real‐time amino acid and glucose monitoring system for the automatic control of nutrient feeding in CHO cell culture using Raman spectroscopy
Authors: Júlia Domján, Eszter Pantea, M. Gyürkés, L. Madarász, Dóra Kozák, A. Farkas, B. Horváth, Zsuzsa Benkő, Z. Nagy, G. Marosi, E. Hirsch
PaperHigh cysteine concentrations in cell culture media lead to oxidative stress and reduced bioprocess performance of recombinant CHO cells
D. Komuczki, Anna Stadermann, Maximilian Bentele, A. Unsoeld, J. Grillari, M. M. Mueller, Albert J Paul, Simon Fischer · 2022 · Biotechnology Journal · DOI
Full title: High cysteine concentrations in cell culture media lead to oxidative stress and reduced bioprocess performance of recombinant CHO cells
Authors: D. Komuczki, Anna Stadermann, Maximilian Bentele, A. Unsoeld, J. Grillari, M. M. Mueller, Albert J Paul, Simon Fischer
PaperCottonseed hydrolysate supplementation alters metabolic and proteomics responses in Chinese hamster ovary cell cultures
Venkata Gayatri Dhara, Swetha Kumar, L. Devine, Harnish Mukesh Naik, R. Cole, Abbie J. More, E. Lau, M. Betenbaugh · 2023 · Biotechnology Journal · DOI
Full title: Cottonseed hydrolysate supplementation alters metabolic and proteomics responses in Chinese hamster ovary cell cultures
Authors: Venkata Gayatri Dhara, Swetha Kumar, L. Devine, Harnish Mukesh Naik, R. Cole, Abbie J. More, E. Lau, M. Betenbaugh
PaperCharacterization of the Ubiquitin-Modified Proteome of Recombinant Chinese Hamster Ovary Cells in Response to Endoplasmic Reticulum Stress.
Selvaprakash, Karuppuchamy, Sideri, Christiana-Kondylo, Henry, Michael, Efeoglu, Esen, Ryan, David, Meleady, Paula · 2024 · Biotechnology journal · DOI
Full title: Characterization of the Ubiquitin-Modified Proteome of Recombinant Chinese Hamster Ovary Cells in Response to Endoplasmic Reticulum Stress.
PaperInhibition of sodium butyrate-induced apoptosis in recombinant Chinese hamster ovary cells by constitutively expressing antisense RNA of caspase-3.
Kim, No Soo, Lee, Gyun Min · 2002 · Biotechnology and bioengineering · DOI
Full title: Inhibition of sodium butyrate-induced apoptosis in recombinant Chinese hamster ovary cells by constitutively expressing antisense RNA of caspase-3.
PaperA novel function for selenium in biological system: selenite as a highly effective iron carrier for Chinese hamster ovary cell growth and monoclonal antibody production.
Zhang, Jinyou, Robinson, David, Salmon, Peter · 2006 · Biotechnology and bioengineering · DOI
Full title: A novel function for selenium in biological system: selenite as a highly effective iron carrier for Chinese hamster ovary cell growth and monoclonal antibody production.
Authors: Zhang, Jinyou, Robinson, David, Salmon, Peter
PaperIdentification of novel small molecule enhancers of protein production by cultured mammalian cells.
Allen, Martin J, Boyce, James P, Trentalange, Michael T, Treiber, David L, Rasmussen, Brian, Tillotson, Benjamin, Davis, Raymond, Reddy, Pranhitha · 2008 · Biotechnology and bioengineering · DOI
Full title: Identification of novel small molecule enhancers of protein production by cultured mammalian cells.
Authors: Allen, Martin J, Boyce, James P, Trentalange, Michael T, Treiber, David L, Rasmussen, Brian, Tillotson, Benjamin, Davis, Raymond, Reddy, Pranhitha
PaperOverexpression of taurine transporter in Chinese hamster ovary cells can enhance cell viability and product yield, while promoting glutamine consumption.
Tabuchi, Hisahiro, Sugiyama, Tomoya, Tanaka, Saeko, Tainaka, Satoshi · 2010 · Biotechnology and bioengineering · DOI
Full title: Overexpression of taurine transporter in Chinese hamster ovary cells can enhance cell viability and product yield, while promoting glutamine consumption.
PaperMolecular polygamy: The promiscuity of l-phenylalanyl-tRNA-synthetase triggers misincorporation of meta- and ortho-tyrosine in monoclonal antibodies expressed by Chinese hamster ovary cells.
Full title: Molecular polygamy: The promiscuity of l-phenylalanyl-tRNA-synthetase triggers misincorporation of meta- and ortho-tyrosine in monoclonal antibodies expressed by Chinese hamster ovary cells.
PaperA multi‐pronged investigation into the effect of glucose starvation and culture duration on fed‐batch CHO cell culture
Fan, Yuzhou, Val, Ioscani Jiménez del, Müller, Christian, Lund, Anne Mathilde, Sen, Jette W., Rasmussen, Søren Kofoed, Kontoravdi, Cleo, Baycin‐Hizal, Deniz, Betenbaugh, Michael J., Weilguny, Dietmar, Andersen, Mikael Rørdam · 2015 · Biotechnology and Bioengineering · DOI
Full title: A multi‐pronged investigation into the effect of glucose starvation and culture duration on fed‐batch CHO cell culture
Authors: Fan, Yuzhou, Val, Ioscani Jiménez del, Müller, Christian, Lund, Anne Mathilde, Sen, Jette W., Rasmussen, Søren Kofoed, Kontoravdi, Cleo, Baycin‐Hizal, Deniz, Betenbaugh, Michael J., Weilguny, Dietmar, Andersen, Mikael Rørdam
PaperMulti‐omic profiling of EPO‐producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production
Ley, Daniel, Seresht, Ali Kazemi, Engmark, Mikael, Magdenoska, Olivera, Nielsen, Kristian Fog, Kildegaard, Helene Faustrup, Andersen, Mikael Rørdam · 2015 · Biotechnology and Bioengineering · DOI
Full title: Multi‐omic profiling of EPO‐producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production
Authors: Ley, Daniel, Seresht, Ali Kazemi, Engmark, Mikael, Magdenoska, Olivera, Nielsen, Kristian Fog, Kildegaard, Helene Faustrup, Andersen, Mikael Rørdam
PaperIntracellular response to process optimization and impact on productivity and product aggregates for a high‐titer CHO cell process
Michael W Handlogten, Allison Lee-O'Brien, G. Roy, S. Levitskaya, Raghavan V. Venkat, Shailendra Singh, Sanjeev Ahuja · 2018 · Biotechnology and Bioengineering · DOI
Full title: Intracellular response to process optimization and impact on productivity and product aggregates for a high‐titer CHO cell process
Authors: Michael W Handlogten, Allison Lee-O'Brien, G. Roy, S. Levitskaya, Raghavan V. Venkat, Shailendra Singh, Sanjeev Ahuja
PaperCharacterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis
Chevallier, Valentine, Schoof, Erwin M., Malphettes, Laetitia, Andersen, Mikael Rørdam, Workman, Christopher T. · 2020 · Biotechnology and Bioengineering · DOI
Full title: Characterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis
Authors: Chevallier, Valentine, Schoof, Erwin M., Malphettes, Laetitia, Andersen, Mikael Rørdam, Workman, Christopher T.
Full title: Production of butyrate and branched-chain amino acid catabolic byproducts by CHO cells in fed-batch culture enhances their specific productivity.
PaperA comparative analysis of recombinant Fab and full‐length antibody production in Chinese hamster ovary cells
Hussain, Hirra, Patel, Tulshi, Ozanne, Angelica M. S., Vito, Davide, Ellis, Mark, Hinchliffe, Matthew, Humphreys, David P., Stephens, Paul E., Sweeney, Bernie, White, James H., Dickson, Alan J., Smales, C. Mark · 2021 · Biotechnology and Bioengineering · DOI
Full title: A comparative analysis of recombinant Fab and full‐length antibody production in Chinese hamster ovary cells
Authors: Hussain, Hirra, Patel, Tulshi, Ozanne, Angelica M. S., Vito, Davide, Ellis, Mark, Hinchliffe, Matthew, Humphreys, David P., Stephens, Paul E., Sweeney, Bernie, White, James H., Dickson, Alan J., Smales, C. Mark
PaperModular development enables rapid design of media for alternative hosts
Biedermann, Andrew M., Gengaro, Isabella R., Rodriguez‐Aponte, Sergio A., Love, Kerry R., Love, J. Christopher · 2021 · Biotechnology and Bioengineering · DOI
Full title: Modular development enables rapid design of media for alternative hosts
Authors: Biedermann, Andrew M., Gengaro, Isabella R., Rodriguez‐Aponte, Sergio A., Love, Kerry R., Love, J. Christopher
PaperMetabolic analysis of the asparagine and glutamine dynamics in an industrial Chinese hamster ovary fed‐batch process
B. Kirsch, Sandra V. Bennun, A. Mendez, Amy S Johnson, Hongxia Wang, Haibo Qiu, Ning Li, S. Lawrence, H. Bak, M. Betenbaugh · 2021 · Biotechnology and Bioengineering · DOI
Full title: Metabolic analysis of the asparagine and glutamine dynamics in an industrial Chinese hamster ovary fed‐batch process
Authors: B. Kirsch, Sandra V. Bennun, A. Mendez, Amy S Johnson, Hongxia Wang, Haibo Qiu, Ning Li, S. Lawrence, H. Bak, M. Betenbaugh
PaperSoft-sensors application for automated feeding control in high-throughput mammalian cell cultures.
Martínez-Monge, Iván, Martínez, Carlos, Decker, Marianne, Udugama, Isuru A, Marín de Mas, Igor, Gernaey, Krist V, Nielsen, Lars K · 2022 · Biotechnology and bioengineering · DOI
Full title: Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures.
Authors: Martínez-Monge, Iván, Martínez, Carlos, Decker, Marianne, Udugama, Isuru A, Marín de Mas, Igor, Gernaey, Krist V, Nielsen, Lars K
PaperOptimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided by design of experiments
Schwarz, Hubert, Lee, Kevin, Castan, Andreas, Chotteau, Véronique · 2023 · Biotechnology and Bioengineering · DOI
Full title: Optimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided by design of experiments
PaperChemical inhibitors of hexokinase‐2 enzyme reduce lactate accumulation, alter glycosylation processing, and produce altered glycoforms in CHO cell cultures
Naik, Harnish Mukesh, Kumar, Swetha, Reddy, Jayanth Venkatarama, Gonzalez, Jacqueline E., McConnell, Brian O., Dhara, Venkata Gayatri, Wang, Tiexin, Yu, Marcella, Antoniewicz, Maciek R., Betenbaugh, Michael J. · 2023 · Biotechnology and Bioengineering · DOI
Full title: Chemical inhibitors of hexokinase‐2 enzyme reduce lactate accumulation, alter glycosylation processing, and produce altered glycoforms in CHO cell cultures
Authors: Naik, Harnish Mukesh, Kumar, Swetha, Reddy, Jayanth Venkatarama, Gonzalez, Jacqueline E., McConnell, Brian O., Dhara, Venkata Gayatri, Wang, Tiexin, Yu, Marcella, Antoniewicz, Maciek R., Betenbaugh, Michael J.
PaperHarnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation
Nöbel, Matthias, Barry, Craig, MacDonald, M. A., Baker, Kym, Shave, Evan, Mahler, Stephen M., Munro, Trent P., Martínez, Verónica S., Nielsen, Lars K., Marcellin, Esteban · 2023 · Biotechnology and Bioengineering · DOI
Full title: Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation
Authors: Nöbel, Matthias, Barry, Craig, MacDonald, M. A., Baker, Kym, Shave, Evan, Mahler, Stephen M., Munro, Trent P., Martínez, Verónica S., Nielsen, Lars K., Marcellin, Esteban
PaperMetabolomic characterization of monoclonal antibody-producing Chinese hamster lung (CHL)-YN cells in glucose-controlled serum-free fed-batch operation.
Sukwattananipaat, Puriwat, Kuroda, Hirotaka, Yamano-Adachi, Noriko, Omasa, Takeshi · 2024 · Biotechnology and bioengineering · DOI
Full title: Metabolomic characterization of monoclonal antibody-producing Chinese hamster lung (CHL)-YN cells in glucose-controlled serum-free fed-batch operation.
PaperFlux Sampling Suggests Metabolic Signatures of High Antibody-Producing CHO Cells.
Meeson, Kate E, Watson, Joanne, Rosser, Susan, Hawke, Ellie, Pitt, Andrew, Moses, Tessa, Pybus, Leon, Rattray, Magnus, Dickson, Alan J, Schwartz, Jean-Marc · 2025 · Biotechnology and bioengineering · DOI
Full title: Flux Sampling Suggests Metabolic Signatures of High Antibody-Producing CHO Cells.
Authors: Meeson, Kate E, Watson, Joanne, Rosser, Susan, Hawke, Ellie, Pitt, Andrew, Moses, Tessa, Pybus, Leon, Rattray, Magnus, Dickson, Alan J, Schwartz, Jean-Marc
PaperLC-HRMS-based targeted metabolomics for high-throughput and quantitative analysis of 21 growth inhibition-related metabolites in Chinese hamster ovary cell fed-batch cultures.
Full title: LC-HRMS-based targeted metabolomics for high-throughput and quantitative analysis of 21 growth inhibition-related metabolites in Chinese hamster ovary cell fed-batch cultures.
PaperEffect of amino acid supplementation on titer and glycosylation distribution in hybridoma cell cultures—Systems biology‐based interpretation using genome‐scale metabolic flux balance model and multivariate data analysis
Thomas M. Reimonn, Seo-Young Park, C. Agarabi, K. Brorson, Seongkyu Yoon · 2016 · Biotechnology progress (Print) · DOI
Full title: Effect of amino acid supplementation on titer and glycosylation distribution in hybridoma cell cultures—Systems biology‐based interpretation using genome‐scale metabolic flux balance model and multivariate data analysis
Authors: Thomas M. Reimonn, Seo-Young Park, C. Agarabi, K. Brorson, Seongkyu Yoon
PaperPrinciples and approach to developing mammalian cell culture media for high cell density perfusion process leveraging established fed-batch media.
Lin, Henry, Leighty, Robert Woodrow, Godfrey, Scott, Wang, Samantha Boran · 2017 · Biotechnology progress · DOI
Full title: Principles and approach to developing mammalian cell culture media for high cell density perfusion process leveraging established fed-batch media.
PaperMultivariate data analysis of growth medium trends affecting antibody glycosylation
Powers, David N., Trunfio, Nicholas, Velugula‐Yellela, Sai Rashmika, Angart, Phillip, Faustino, Anneliese M., Agarabi, Cyrus · 2019 · Biotechnology Progress · DOI
Full title: Multivariate data analysis of growth medium trends affecting antibody glycosylation
Authors: Powers, David N., Trunfio, Nicholas, Velugula‐Yellela, Sai Rashmika, Angart, Phillip, Faustino, Anneliese M., Agarabi, Cyrus
PaperEffects of cysteine, asparagine, or glutamine limitations in Chinese hamster ovary cell batch and fed-batch cultures.
Ghaffari, Navid, Jardon, Mario A, Krahn, Natalie, Butler, Michael, Kennard, Malcolm, Turner, Robin F B, Gopaluni, Bhushan, Piret, James M · 2020 · Biotechnology progress · DOI
Full title: Effects of cysteine, asparagine, or glutamine limitations in Chinese hamster ovary cell batch and fed-batch cultures.
Authors: Ghaffari, Navid, Jardon, Mario A, Krahn, Natalie, Butler, Michael, Kennard, Malcolm, Turner, Robin F B, Gopaluni, Bhushan, Piret, James M
PaperRaman‐based dynamic feeding strategies using real‐time glucose concentration monitoring system during adalimumab producing CHO cell cultivation
Júlia Domján, Annamária Fricska, L. Madarász, M. Gyürkés, Á. Köte, A. Farkas, Panna Vass, C. Fehér, B. Horváth, Kalman Könczöl, H. Pataki, Z. Nagy, G. Marosi, E. Hirsch · 2020 · Biotechnology progress (Print) · DOI
Full title: Raman‐based dynamic feeding strategies using real‐time glucose concentration monitoring system during adalimumab producing CHO cell cultivation
Authors: Júlia Domján, Annamária Fricska, L. Madarász, M. Gyürkés, Á. Köte, A. Farkas, Panna Vass, C. Fehér, B. Horváth, Kalman Könczöl, H. Pataki, Z. Nagy, G. Marosi, E. Hirsch
PaperCharacterization of soy protein hydrolysates and influence of its iron content on monoclonal antibody production by a murine hybridoma cell line.
Djemal, Leïla, von Hagen, Joerg, Kolmar, Harald, Deparis, Véronique · 2021 · Biotechnology progress · DOI
Full title: Characterization of soy protein hydrolysates and influence of its iron content on monoclonal antibody production by a murine hybridoma cell line.
Authors: Djemal, Leïla, von Hagen, Joerg, Kolmar, Harald, Deparis, Véronique
PaperPreventing pyruvate kinase muscle expression in Chinese hamster ovary cells curbs lactogenic behavior by altering glycolysis, gating pyruvate generation, and increasing pyruvate flux into the TCA cycle.
Full title: Preventing pyruvate kinase muscle expression in Chinese hamster ovary cells curbs lactogenic behavior by altering glycolysis, gating pyruvate generation, and increasing pyruvate flux into the TCA cycle.
PaperAn automated high inoculation density fed‐batch bioreactor, enabled through N‐1 perfusion, accommodates clonal diversity and doubles titers
Olin, Mikayla, Wolnick, Nicolas, Crittenden, Hunter, Quach, Anthony, Russell, Brian, Hendrick, Shannon, Armstrong, Julia, Webster, Thaddaeus A., Hadley, Brian C., Dickson, Marissa, Hodgkins, Jessica, Busa, Kevin, Connolly, R., Downey, Brandon · 2023 · Biotechnology Progress · DOI
Full title: An automated high inoculation density fed‐batch bioreactor, enabled through N‐1 perfusion, accommodates clonal diversity and doubles titers
PaperMultivariate data analysis of process parameters affecting the growth and productivity of stable Chinese hamster ovary cell pools expressing SARS‐CoV ‐2 spike protein as vaccine antigen in early process development
Full title: Multivariate data analysis of process parameters affecting the growth and productivity of stable Chinese hamster ovary cell pools expressing SARS‐CoV ‐2 spike protein as vaccine antigen in early process development
PaperStrategies to improve CHO cell culture performance: Targeted deletion of amino acid catabolism and apoptosis genes paired with growth inhibitor supplementation.
Full title: Strategies to improve CHO cell culture performance: Targeted deletion of amino acid catabolism and apoptosis genes paired with growth inhibitor supplementation.
Full title: CHO stable pool fed-batch process development of SARS-CoV-2 spike protein production: Impact of aeration conditions and feeding strategies.
PaperUse of a Plackett-Burman statistical design to determine the effect of selected amino acids on monoclonal antibody production in CHO cells.
González-Leal, I J, Carrillo-Cocom, L M, Ramírez-Medrano, A, López-Pacheco, F, Bulnes-Abundis, D, Webb-Vargas, Y, Alvarez, M M · 2011 · Biotechnology progress · DOI
Full title: Use of a Plackett-Burman statistical design to determine the effect of selected amino acids on monoclonal antibody production in CHO cells.
Authors: González-Leal, I J, Carrillo-Cocom, L M, Ramírez-Medrano, A, López-Pacheco, F, Bulnes-Abundis, D, Webb-Vargas, Y, Alvarez, M M
PaperIncreased MSX level improves biological productivity and production stability in multiple recombinant GS CHO cell lines
Tian, Jun, He, Qin, Oliveira, Christopher L., Qian, Yueming, Egan, Susan, Xu, Jianlin, Qian, Nan‐Xin, Langsdorf, Erik F., Warrack, Bethanne M., Aranı́bar, Nelly, Reily, Michael D., Borys, Michael, Li, Zheng Jian · 2020 · Engineering in Life Sciences · DOI
Full title: Increased MSX level improves biological productivity and production stability in multiple recombinant GS CHO cell lines
Authors: Tian, Jun, He, Qin, Oliveira, Christopher L., Qian, Yueming, Egan, Susan, Xu, Jianlin, Qian, Nan‐Xin, Langsdorf, Erik F., Warrack, Bethanne M., Aranı́bar, Nelly, Reily, Michael D., Borys, Michael, Li, Zheng Jian
PaperCellular and molecular outcomes of glutamine supplementation in the brain of succinic semialdehyde dehydrogenase-deficient mice.
Brown, Madalyn N, Gibson, K Michael, Schmidt, Michelle A, Walters, Dana C, Arning, Erland, Bottiglieri, Teodoro, Roullet, Jean-Baptiste · 2020 · JIMD reports · DOI
Full title: Cellular and molecular outcomes of glutamine supplementation in the brain of succinic semialdehyde dehydrogenase-deficient mice.
Authors: Brown, Madalyn N, Gibson, K Michael, Schmidt, Michelle A, Walters, Dana C, Arning, Erland, Bottiglieri, Teodoro, Roullet, Jean-Baptiste
PaperDietary stevioside supplementation increases feed intake by altering the hypothalamic transcriptome profile and gut microbiota in broiler chickens.
Jiang, Jingle, Qi, Lina, Lv, Zengpeng, Wei, Quanwei, Shi, Fangxiong · 2021 · Journal of the science of food and agriculture · DOI
Full title: Dietary stevioside supplementation increases feed intake by altering the hypothalamic transcriptome profile and gut microbiota in broiler chickens.
PaperFolate deficiency and over-supplementation causes impaired folate metabolism: Regulation and adaptation mechanisms in Caenorhabditis elegans.
Ortbauer, Martina, Ripper, Doris, Fuhrmann, Thomas, Lassi, Maximilian, Auernigg-Haselmaier, Sandra, Stiegler, Christina, König, Jürgen · 2016 · Molecular nutrition & food research · DOI
Full title: Folate deficiency and over-supplementation causes impaired folate metabolism: Regulation and adaptation mechanisms in Caenorhabditis elegans.
PaperMetabolomics profiling of extracellular metabolites in recombinant Chinese Hamster Ovary fed-batch culture.
Chong, William P K, Goh, Lin Tang, Reddy, Satty G, Yusufi, Faraaz N K, Lee, Dong Yup, Wong, Niki S C, Heng, Chew Kiat, Yap, Miranda G S, Ho, Ying Swan · 2009 · Rapid communications in mass spectrometry : RCM · DOI
Full title: Metabolomics profiling of extracellular metabolites in recombinant Chinese Hamster Ovary fed-batch culture.
Authors: Chong, William P K, Goh, Lin Tang, Reddy, Satty G, Yusufi, Faraaz N K, Lee, Dong Yup, Wong, Niki S C, Heng, Chew Kiat, Yap, Miranda G S, Ho, Ying Swan
Year: 2009
Venue: Rapid communications in mass spectrometry : RCM
PaperEffects of Dietary Supplementation of Coenzyme Q10 on Growth Performance, Biochemical and Physiological Attributes of Rainbow Trout (Oncorhynchus mykiss).
Asgari, Hajar, Jalali, Sayed Mohammad Ali, Faghani, Mostafa, Hematzadeh, Azar · 2025 · Veterinary medicine and science · DOI
Full title: Effects of Dietary Supplementation of Coenzyme Q10 on Growth Performance, Biochemical and Physiological Attributes of Rainbow Trout (Oncorhynchus mykiss).
PaperResponse of plasma and gastrointestinal melatonin, plasma cortisol and activity rhythms of European sea bass (Dicentrarchus labrax) to dietary supplementation with tryptophan and melatonin.
Herrero, M J, Martínez, F J, Míguez, J M, Madrid, J A · 2007 · Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · DOI
Full title: Response of plasma and gastrointestinal melatonin, plasma cortisol and activity rhythms of European sea bass (Dicentrarchus labrax) to dietary supplementation with tryptophan and melatonin.
Authors: Herrero, M J, Martínez, F J, Míguez, J M, Madrid, J A
Year: 2007
Venue: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
PaperCodon optimization of xylA gene for recombinant glucose isomerase production in Pichia pastoris and fed-batch feeding strategies to fine-tune bioreactor performance.
Ata, Özge, Boy, Erdem, Güneş, Hande, Çalık, Pınar · 2015 · Bioprocess and biosystems engineering · DOI
Full title: Codon optimization of xylA gene for recombinant glucose isomerase production in Pichia pastoris and fed-batch feeding strategies to fine-tune bioreactor performance.
PaperEnhanced production of recombinant proteins by a small molecule protein synthesis enhancer in combination with an antioxidant in recombinant Chinese hamster ovary cells
Joseph Camire, Dongjoo Kim, Soonjo Kwon · 2017 · Bioprocess and biosystems engineering (Print) · DOI
Full title: Enhanced production of recombinant proteins by a small molecule protein synthesis enhancer in combination with an antioxidant in recombinant Chinese hamster ovary cells
Authors: Joseph Camire, Dongjoo Kim, Soonjo Kwon
Year: 2017
Venue: Bioprocess and biosystems engineering (Print)
PaperAll-trans retinoic acid in combination with sodium butyrate enhances specific monoclonal antibody productivity in recombinant CHO cell line
Mahmood Rahimi-Zarchi, S. Shojaosadati, M. Amiri, M. Jeddi-Tehrani, F. Shokri · 2018 · Bioprocess and biosystems engineering (Print) · DOI
Full title: All-trans retinoic acid in combination with sodium butyrate enhances specific monoclonal antibody productivity in recombinant CHO cell line
Authors: Mahmood Rahimi-Zarchi, S. Shojaosadati, M. Amiri, M. Jeddi-Tehrani, F. Shokri
Year: 2018
Venue: Bioprocess and biosystems engineering (Print)
PaperFeedback control of two supplemental feeds during fed-batch culture on a platform process using inline Raman models for glucose and phenylalanine concentration.
Webster, Thaddaeus A, Hadley, Brian C, Dickson, Marissa, Busa, John K, Jaques, Colin, Mason, Carrie · 2021 · Bioprocess and biosystems engineering · DOI
Full title: Feedback control of two supplemental feeds during fed-batch culture on a platform process using inline Raman models for glucose and phenylalanine concentration.
Authors: Webster, Thaddaeus A, Hadley, Brian C, Dickson, Marissa, Busa, John K, Jaques, Colin, Mason, Carrie
PaperAutomated Raman feed-back control of multiple supplemental feeds to enable an intensified high inoculation density fed-batch platform process.
Webster, Thaddaeus A, Hadley, Brian C, Dickson, Marissa, Hodgkins, Jessica, Olin, Mikayla, Wolnick, Nicolas, Armstrong, Julia, Mason, Carrie, Downey, Brandon · 2023 · Bioprocess and biosystems engineering · DOI
Full title: Automated Raman feed-back control of multiple supplemental feeds to enable an intensified high inoculation density fed-batch platform process.
PaperMechanistic insights into sodium citrate-induced metabolic rewiring for enhanced S-adenosylmethionine synthesis via transcriptomics and constraint-based modeling.
Dong, Le, Song, Weijing, Li, Zhongyue, Qian, Jiangchao, Xu, Feng, Huang, Mingzhi · 2026 · Bioprocess and biosystems engineering · DOI
Full title: Mechanistic insights into sodium citrate-induced metabolic rewiring for enhanced S-adenosylmethionine synthesis via transcriptomics and constraint-based modeling.
PaperChickpea protein hydrolysate as a substitute for serum in cell culture
Girón‐Calle, Julio, Vioque, Javier, Pedroche, Justo, Alaiz, Manuel, Yust, María del Mar, Megías, Cristina, Millán, Francisco · 2008 · Cytotechnology · DOI
Full title: Chickpea protein hydrolysate as a substitute for serum in cell culture
Authors: Girón‐Calle, Julio, Vioque, Javier, Pedroche, Justo, Alaiz, Manuel, Yust, María del Mar, Megías, Cristina, Millán, Francisco
Full title: Adaptation and cultivation of permanent fish cell line CCO in serum-free medium and influence of protein hydrolysates on growth performance
PaperDevelopment of a chemically defined platform fed-batch culture media for monoclonal antibody-producing CHO cell lines with optimized choline content
Full title: Development of a chemically defined platform fed-batch culture media for monoclonal antibody-producing CHO cell lines with optimized choline content
PaperCombination of temperature shift and hydrolysate addition regulates anti-IgE monoclonal antibody charge heterogeneity in Chinese hamster ovary cell fed-batch culture
Full title: Combination of temperature shift and hydrolysate addition regulates anti-IgE monoclonal antibody charge heterogeneity in Chinese hamster ovary cell fed-batch culture
PaperDietary probiotic supplementation (Shewanella putrefaciens Pdp11) modulates gut microbiota and promotes growth and condition in Senegalese sole larviculture.
Lobo, Carmen, Moreno-Ventas, Xabier, Tapia-Paniagua, Silvana, Rodríguez, Covadonga, Moriñigo, Miguel A, de La Banda, Inés García · 2014 · Fish physiology and biochemistry · DOI
Full title: Dietary probiotic supplementation (Shewanella putrefaciens Pdp11) modulates gut microbiota and promotes growth and condition in Senegalese sole larviculture.
Authors: Lobo, Carmen, Moreno-Ventas, Xabier, Tapia-Paniagua, Silvana, Rodríguez, Covadonga, Moriñigo, Miguel A, de La Banda, Inés García
PaperDietary indispensable amino acids profile affects protein utilization and growth of Senegalese sole larvae.
Canada, Paula, Engrola, Sofia, Richard, Nadège, Lopes, Ana Filipa, Pinto, Wilson, Valente, Luísa M P, Conceição, Luís E C · 2016 · Fish physiology and biochemistry · DOI
Full title: Dietary indispensable amino acids profile affects protein utilization and growth of Senegalese sole larvae.
Authors: Canada, Paula, Engrola, Sofia, Richard, Nadège, Lopes, Ana Filipa, Pinto, Wilson, Valente, Luísa M P, Conceição, Luís E C
PaperEffect of N-acetyl cysteine and glycine supplementation on growth performance, glutathione synthesis, and antioxidative ability of grass carp, Ctenopharyngodon idella.
Xie, Shiwei, Tian, Lixia, Niu, Jin, Liang, Guiying, Liu, Yongjian · 2017 · Fish physiology and biochemistry · DOI
Full title: Effect of N-acetyl cysteine and glycine supplementation on growth performance, glutathione synthesis, and antioxidative ability of grass carp, Ctenopharyngodon idella.
PaperThe study of ameliorative effect of dietary supplementation of vitamin C, vitamin E, and tryptophan on Labeo rohita (Cyprinidae) fry exposed to intense light.
Khan, Nawaz Alam, Sharma, JaiGopal, Chakrabarti, Rina · 2019 · Fish physiology and biochemistry · DOI
Full title: The study of ameliorative effect of dietary supplementation of vitamin C, vitamin E, and tryptophan on Labeo rohita (Cyprinidae) fry exposed to intense light.
Authors: Khan, Nawaz Alam, Sharma, JaiGopal, Chakrabarti, Rina
PaperDietary cobalt supplementation improves growth and body composition and induces the expression of growth and stress response genes in Tor putitora.
Younus, Naima, Zuberi, Amina, Rashidpour, Ania, Metón, Isidoro · 2020 · Fish physiology and biochemistry · DOI
Full title: Dietary cobalt supplementation improves growth and body composition and induces the expression of growth and stress response genes in Tor putitora.
PaperEPA and DHA promote cell proliferation and enhance activity of the Akt-TOR-S6K anabolic signaling pathway in primary muscle cells of turbot (Scophthalmus maximus L.)
Ya Gao, Chengdong Liu, Xuan Wang, Huihui Zhou, K. Mai, G. He · 2024 · Fish Physiology & Biochemistry · DOI
Full title: EPA and DHA promote cell proliferation and enhance activity of the Akt-TOR-S6K anabolic signaling pathway in primary muscle cells of turbot (Scophthalmus maximus L.)
Authors: Ya Gao, Chengdong Liu, Xuan Wang, Huihui Zhou, K. Mai, G. He
PaperInteraction of supplementary L-carnitine and dietary energy levels on feed utilization and blood constituents in New Zealand White rabbits reared under summer conditions.
Ayyat, Mohamed S, Abd El-Latif, Khaled M, Helal, Amera A, Al-Sagheer, Adham A · 2021 · Tropical animal health and production · DOI
Full title: Interaction of supplementary L-carnitine and dietary energy levels on feed utilization and blood constituents in New Zealand White rabbits reared under summer conditions.
Authors: Ayyat, Mohamed S, Abd El-Latif, Khaled M, Helal, Amera A, Al-Sagheer, Adham A
PaperDietary supplementation with curcumin nanomicelles, curcumin, and turmeric affects growth performance and silver nanoparticle toxicity in Cyprinus carpio.
Pirani, Fereshteh, Moradi, Shadieh, Ashouri, Samyar, Johari, Seyed Ali, Ghaderi, Edris, Kim, Hoi Pin, Yu, Il Je · 2021 · Environmental science and pollution research international · DOI
Full title: Dietary supplementation with curcumin nanomicelles, curcumin, and turmeric affects growth performance and silver nanoparticle toxicity in Cyprinus carpio.
Authors: Pirani, Fereshteh, Moradi, Shadieh, Ashouri, Samyar, Johari, Seyed Ali, Ghaderi, Edris, Kim, Hoi Pin, Yu, Il Je
Year: 2021
Venue: Environmental science and pollution research international
PaperEffects of Organic Selenium Supplementation on Growth, Accumulation, Haematology and Histopathology of Juvenile Barramundi (Lates calcarifer) Fed High Soybean Meal Diets.
Ilham, Ilham, Siddik, Muhammad Abu Bakar, Fotedar, Ravi · 2016 · Biological trace element research · DOI
Full title: Effects of Organic Selenium Supplementation on Growth, Accumulation, Haematology and Histopathology of Juvenile Barramundi (Lates calcarifer) Fed High Soybean Meal Diets.
Authors: Ilham, Ilham, Siddik, Muhammad Abu Bakar, Fotedar, Ravi
PaperDietary Chromium Picolinate Supplementation Affects Growth, Whole-Body Composition, and Gene Expression Related to Glucose Metabolism and Lipogenesis in Juvenile Blunt Snout Bream, Megalobrama amblycephala.
Ren, Mingchun, Mokrani, Ahmed, Liang, Hualiang, Ji, Ke, Xie, Jun, Ge, Xianping, Liu, Bo · 2018 · Biological trace element research · DOI
Full title: Dietary Chromium Picolinate Supplementation Affects Growth, Whole-Body Composition, and Gene Expression Related to Glucose Metabolism and Lipogenesis in Juvenile Blunt Snout Bream, Megalobrama amblycephala.
Authors: Ren, Mingchun, Mokrani, Ahmed, Liang, Hualiang, Ji, Ke, Xie, Jun, Ge, Xianping, Liu, Bo
PaperLeucine supplementation at the onset of high-fat feeding does not prevent weight gain or improve glycemic regulation in male Sprague-Dawley rats.
Baum, Jamie I, Washington, Tyrone A, Shouse, Stephanie A, Bottje, Walter, Dridi, Sami, Davis, Gina, Smith, Dameon · 2016 · Journal of physiology and biochemistry · DOI
Full title: Leucine supplementation at the onset of high-fat feeding does not prevent weight gain or improve glycemic regulation in male Sprague-Dawley rats.
Authors: Baum, Jamie I, Washington, Tyrone A, Shouse, Stephanie A, Bottje, Walter, Dridi, Sami, Davis, Gina, Smith, Dameon
PaperThe influence of high dietary protein, energy and mineral intake on deficient young camel (Camelus dromedarius)--II. Changes in mineral status.
Faye, B, Saint-Martin, G, Cherrier, R, Ruffa, A · 1992 · Comparative biochemistry and physiology. Comparative physiology · DOI
Full title: The influence of high dietary protein, energy and mineral intake on deficient young camel (Camelus dromedarius)--II. Changes in mineral status.
Authors: Faye, B, Saint-Martin, G, Cherrier, R, Ruffa, A
Year: 1992
Venue: Comparative biochemistry and physiology. Comparative physiology
PaperDietary guanidinoacetic acid supplementation improves water holding capacity and lowers free amino acid concentration of fresh meat in finishing pigs fed with various dietary protein levels.
Wang, Lu, Wang, Yubo, Xu, Doudou, He, Linjuan, Zhu, Xiaoyan, Yin, Jingdong · 2022 · Animal nutrition (Zhongguo xu mu shou yi xue hui) · DOI
Full title: Dietary guanidinoacetic acid supplementation improves water holding capacity and lowers free amino acid concentration of fresh meat in finishing pigs fed with various dietary protein levels.
PaperEffects of dietary supplementation of Bacillus subtilis DSM 32315 on growth, immune response and acute ammonia stress tolerance of Nile tilapia (Oreochromis niloticus) fed with high or low protein diets.
Liao, Zhihong, Liu, Yantao, Wei, Hanlin, He, Xuanshu, Wang, Ziqiao, Zhuang, Zhenxiao, Zhao, Wei, Masagounder, Karthik, He, Juyun, Niu, Jin · 2023 · Animal nutrition (Zhongguo xu mu shou yi xue hui) · DOI
Full title: Effects of dietary supplementation of Bacillus subtilis DSM 32315 on growth, immune response and acute ammonia stress tolerance of Nile tilapia (Oreochromis niloticus) fed with high or low protein diets.
PaperEpigallocatechin-3-gallate supplementation regulates glucose redistribution through its potential endogenous receptor in grass carp (Ctenopharyngodon idella).
Full title: Epigallocatechin-3-gallate supplementation regulates glucose redistribution through its potential endogenous receptor in grass carp (Ctenopharyngodon idella).
PaperDaily rhythms of locomotor activity, feeding behavior and dietary selection in Nile tilapia (Oreochromis niloticus).
Fortes-Silva, R, Martínez, F J, Villarroel, M, Sánchez-Vázquez, F J · 2010 · Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · DOI
Full title: Daily rhythms of locomotor activity, feeding behavior and dietary selection in Nile tilapia (Oreochromis niloticus).
Authors: Fortes-Silva, R, Martínez, F J, Villarroel, M, Sánchez-Vázquez, F J
Year: 2010
Venue: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
PaperDietary probiotic supplementation modulated gut microbiota and improved growth of juvenile rainbow trout (Oncorhynchus mykiss).
Ramos, M A, Weber, B, Gonçalves, J F, Santos, G A, Rema, P, Ozório, R O A · 2013 · Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · DOI
Full title: Dietary probiotic supplementation modulated gut microbiota and improved growth of juvenile rainbow trout (Oncorhynchus mykiss).
Authors: Ramos, M A, Weber, B, Gonçalves, J F, Santos, G A, Rema, P, Ozório, R O A
Year: 2013
Venue: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
PaperEffects of bioprocessed soybean meal and nucleotide supplementation on growth, physiology and histomorphology in largemouth bass, Micropterus salmoides, juveniles.
Romano, Nicholas, Fischer, Hayden, Rossi, Waldemar, Quintero, Herbert, Limbaugh, Noah, Sinha, Amit Kumar · 2021 · Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · DOI
Full title: Effects of bioprocessed soybean meal and nucleotide supplementation on growth, physiology and histomorphology in largemouth bass, Micropterus salmoides, juveniles.
PaperEffects of vitamin A supplementation on ovarian development of Astyanax lacustris (Teleostei: Characidae) during the non-breeding season.
da Silva, Joseane, Brambila-Souza, Gabriela, Araujo, Daniel de Magalhães, Moreira, Renata G · 2022 · Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · DOI
Full title: Effects of vitamin A supplementation on ovarian development of Astyanax lacustris (Teleostei: Characidae) during the non-breeding season.
Authors: da Silva, Joseane, Brambila-Souza, Gabriela, Araujo, Daniel de Magalhães, Moreira, Renata G
Year: 2022
Venue: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
PaperProtective effects of dietary icariin on lipopolysaccharide-induced acute oxidative stress and hepatopancreas injury in Chinese mitten crab, Eriocheir sinensis.
Full title: Protective effects of dietary icariin on lipopolysaccharide-induced acute oxidative stress and hepatopancreas injury in Chinese mitten crab, Eriocheir sinensis.
PaperA Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering
Liang, Chenguang, Chiang, Austin W.T., Hansen, Anders Holmgaard, Arnsdorf, Johnny, Schoffelen, Sanne, Sorrentino, James T., Kellman, Benjamin P., Bao, Bokan, Voldborg, Björn G., Lewis, Nathan E. · 2020 · Current Research in Biotechnology · DOI
Full title: A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering
Authors: Liang, Chenguang, Chiang, Austin W.T., Hansen, Anders Holmgaard, Arnsdorf, Johnny, Schoffelen, Sanne, Sorrentino, James T., Kellman, Benjamin P., Bao, Bokan, Voldborg, Björn G., Lewis, Nathan E.
PaperEvaluating dynamic effects of dietary glycerol monolaurate on the productive performance and flesh quality of large yellow croaker (Larimichthys crocea).
Full title: Evaluating dynamic effects of dietary glycerol monolaurate on the productive performance and flesh quality of large yellow croaker (Larimichthys crocea).
PaperInfluence of dietary resveratrol supplementation on integrity and colloidal characteristics of Myofibrillar proteins in broiler chicken breast meat.
Full title: Influence of dietary resveratrol supplementation on integrity and colloidal characteristics of Myofibrillar proteins in broiler chicken breast meat.
PaperEffect of N-acetyl cysteine and glycine supplementation on growth performance, glutathione synthesis, anti-oxidative and immune ability of Nile tilapia, Oreochromis niloticus.
Xie, Shiwei, Zhou, Weiwen, Tian, Lixia, Niu, Jin, Liu, Yongjian · 2016 · Fish & shellfish immunology · DOI
Full title: Effect of N-acetyl cysteine and glycine supplementation on growth performance, glutathione synthesis, anti-oxidative and immune ability of Nile tilapia, Oreochromis niloticus.
PaperEffect of dietary supplementation with apple cider vinegar and propionic acid on hemolymph chemistry, intestinal microbiota and histological structure of hepatopancreas in white shrimp, Litopenaeus vannamei.
Pourmozaffar, Sajjad, Hajimoradloo, Abdolmajid, Paknejad, Hamed, Rameshi, Hossein · 2019 · Fish & shellfish immunology · DOI
Full title: Effect of dietary supplementation with apple cider vinegar and propionic acid on hemolymph chemistry, intestinal microbiota and histological structure of hepatopancreas in white shrimp, Litopenaeus vannamei.
PaperDietary taurine modulates hepatic oxidative status, ER stress and inflammation in juvenile turbot (Scophthalmus maximus L.) fed high carbohydrate diets.
Zhang, Yue, Wei, Zehong, Yang, Mengxi, Liu, Danni, Pan, Mingzhu, Wu, Chenglong, Zhang, Wenbing, Mai, Kangsen · 2021 · Fish & shellfish immunology · DOI
Full title: Dietary taurine modulates hepatic oxidative status, ER stress and inflammation in juvenile turbot (Scophthalmus maximus L.) fed high carbohydrate diets.
PaperModulation of growth performance, gut microflora, non-specific immunity and gene expression of proinflammatory cytokines in shabout (Tor grypus) upon dietary prebiotic supplementation.
Full title: Modulation of growth performance, gut microflora, non-specific immunity and gene expression of proinflammatory cytokines in shabout (Tor grypus) upon dietary prebiotic supplementation.
PaperAdministration of EPA improves lipopolysaccharide-induced intestinal dysfunction in turbot (Scophthalmus maximus L.) through modulation of TORC1 signaling.
Gao, Zongyu, Gao, Ya, Wang, Xuan, Wang, Tingting, Zhou, Huihui, Liu, Chengdong, Mai, Kangsen, He, Gen · 2025 · Fish & shellfish immunology · DOI
Full title: Administration of EPA improves lipopolysaccharide-induced intestinal dysfunction in turbot (Scophthalmus maximus L.) through modulation of TORC1 signaling.
Authors: Gao, Zongyu, Gao, Ya, Wang, Xuan, Wang, Tingting, Zhou, Huihui, Liu, Chengdong, Mai, Kangsen, He, Gen
PaperSulforaphane attenuates HFD-induced enteritis in yellow river carp by restoring immune homeostasis, repairing intestinal barrier, and modulating gut microbiota.
Full title: Sulforaphane attenuates HFD-induced enteritis in yellow river carp by restoring immune homeostasis, repairing intestinal barrier, and modulating gut microbiota.
PaperNitrogen supplementation ameliorates product quality and quantity during high cell density bioreactor studies of Pichia pastoris: A case study with proteolysis prone streptokinase.
Adivitiya, Babbal, Mohanty, Shilpa, Khasa, Yogender Pal · 2021 · International journal of biological macromolecules · DOI
Full title: Nitrogen supplementation ameliorates product quality and quantity during high cell density bioreactor studies of Pichia pastoris: A case study with proteolysis prone streptokinase.
Authors: Adivitiya, Babbal, Mohanty, Shilpa, Khasa, Yogender Pal
Year: 2021
Venue: International journal of biological macromolecules
PaperHigh glucose enhances cAMP level and extracellular signal-regulated kinase phosphorylation in Chinese hamster ovary cell: Usage of Br-cAMP in foreign protein β-galactosidase expression.
Lin, Hsiao-Hsien, Lee, Tsung-Yih, Liu, Ting-Wei, Tseng, Ching-Ping · 2017 · Journal of bioscience and bioengineering · DOI
Full title: High glucose enhances cAMP level and extracellular signal-regulated kinase phosphorylation in Chinese hamster ovary cell: Usage of Br-cAMP in foreign protein β-galactosidase expression.
PaperDifferential expression of microRNAs in recombinant Chinese hamster ovary cells treated with sodium butyrate using digital RNA counting.
Lim, Sung-Min, Park, Sun-Hye, Lee, Joo-Hyoung, Kim, Sun Hong, Kim, Jee Yon, Min, Jeong-Ki, Lee, Gyun Min, Kim, Yeon-Gu · 2018 · Journal of biotechnology · DOI
Full title: Differential expression of microRNAs in recombinant Chinese hamster ovary cells treated with sodium butyrate using digital RNA counting.
Authors: Lim, Sung-Min, Park, Sun-Hye, Lee, Joo-Hyoung, Kim, Sun Hong, Kim, Jee Yon, Min, Jeong-Ki, Lee, Gyun Min, Kim, Yeon-Gu
PaperXylanase supplementation of pelleted wheat-based diets increases growth efficiency and apparent metabolizable energy and decreases viscosity of intestinal contents in broilers.
Gorenz, Brad, Iseri, Vanessa, Rubach, Jon, Dilger, Ryan N · 2022 · Poultry science · DOI
Full title: Xylanase supplementation of pelleted wheat-based diets increases growth efficiency and apparent metabolizable energy and decreases viscosity of intestinal contents in broilers.
Authors: Gorenz, Brad, Iseri, Vanessa, Rubach, Jon, Dilger, Ryan N
PaperPhytase supplementation in sorghum-based diet enhances nutrient digestibility, energy utilization, and antioxidant status of Campbell ducks.
Li, Z, Raziq, F, Khan, M T, Ali, S, Ullah, A, Ahmed, I, Alfaleh, A A, Albalawi, M A, Ahmed, A E, Al-Hoshani, N, Yuan, H · 2025 · Poultry science · DOI
Full title: Phytase supplementation in sorghum-based diet enhances nutrient digestibility, energy utilization, and antioxidant status of Campbell ducks.
Authors: Li, Z, Raziq, F, Khan, M T, Ali, S, Ullah, A, Ahmed, I, Alfaleh, A A, Albalawi, M A, Ahmed, A E, Al-Hoshani, N, Yuan, H
PaperExpression in CHO cells of a bacterial biosynthetic pathway producing a small non-ribosomal peptide aldehyde prevents proteolysis of recombinant proteins.
Guadarrama-Pérez, Violeta, Aguilar, César, Porras-Sanjuanico, Alberto, Merino, Enrique, Ramírez, Octavio T, Barona-Gómez, Francisco, Palomares, Laura A · 2024 · Metabolic engineering · DOI
Full title: Expression in CHO cells of a bacterial biosynthetic pathway producing a small non-ribosomal peptide aldehyde prevents proteolysis of recombinant proteins.
Authors: Guadarrama-Pérez, Violeta, Aguilar, César, Porras-Sanjuanico, Alberto, Merino, Enrique, Ramírez, Octavio T, Barona-Gómez, Francisco, Palomares, Laura A
PaperAla-Cys-Cys-Ala dipeptide dimer alleviates problematic cysteine and cystine levels in media formulations and enhances CHO cell growth and metabolism.
Full title: Ala-Cys-Cys-Ala dipeptide dimer alleviates problematic cysteine and cystine levels in media formulations and enhances CHO cell growth and metabolism.
PaperDL-methionyl-DL-methionine as an efficient methionine source for promoting zootechnical performance and methionine-related pathways in the whiteleg shrimp (Penaeus vannamei)
M. Machado, S. Fernández-Boo, Carla Teixeira, Michael N. Viegas, R. Serradeiro, J. Dias, B. Costas, K. Masagounder · 2023 · British Journal of Nutrition · DOI
Full title: DL-methionyl-DL-methionine as an efficient methionine source for promoting zootechnical performance and methionine-related pathways in the whiteleg shrimp (Penaeus vannamei)
Authors: M. Machado, S. Fernández-Boo, Carla Teixeira, Michael N. Viegas, R. Serradeiro, J. Dias, B. Costas, K. Masagounder
PaperEffects of feeding propylene glycol on dry matter intake, lactation performance, energy balance and blood metabolites in early lactation dairy cows.
Liu, Q, Wang, C, Yang, W Z, Zhang, W W, Yang, X M, He, D C, Dong, K H, Huang, Y X · 2009 · Animal : an international journal of animal bioscience · DOI
Full title: Effects of feeding propylene glycol on dry matter intake, lactation performance, energy balance and blood metabolites in early lactation dairy cows.
Authors: Liu, Q, Wang, C, Yang, W Z, Zhang, W W, Yang, X M, He, D C, Dong, K H, Huang, Y X
Year: 2009
Venue: Animal : an international journal of animal bioscience
PaperRepeated acidosis challenges and live yeast supplementation shape rumen microbiota and fermentations and modulate inflammatory status in sheep.
Silberberg, M, Chaucheyras-Durand, F, Commun, L, Mialon, M M, Monteils, V, Mosoni, P, Morgavi, D P, Martin, C · 2013 · Animal : an international journal of animal bioscience · DOI
Full title: Repeated acidosis challenges and live yeast supplementation shape rumen microbiota and fermentations and modulate inflammatory status in sheep.
Authors: Silberberg, M, Chaucheyras-Durand, F, Commun, L, Mialon, M M, Monteils, V, Mosoni, P, Morgavi, D P, Martin, C
Year: 2013
Venue: Animal : an international journal of animal bioscience
PaperThe effect of supplementing pony diets with yeast on 2. The faecal microbiome.
Garber, A, Hastie, P M, Farci, V, McGuinness, D, Bulmer, L, Alzahal, O, Murray, J M D · 2020 · Animal : an international journal of animal bioscience · DOI
Full title: The effect of supplementing pony diets with yeast on 2. The faecal microbiome.
Authors: Garber, A, Hastie, P M, Farci, V, McGuinness, D, Bulmer, L, Alzahal, O, Murray, J M D
Year: 2020
Venue: Animal : an international journal of animal bioscience
PaperPoria cocos Polysaccharide Delays Aging by Enhancing the Antioxidant Ability and Suppressing the Expression of the Branched-Chain Amino Acid Transferase-Encoding Gene in Drosophila melanogaster.
Kai Zhu, Dongsheng Du, Yuxia Shi, Fan Hu, Wenting Zhang, Hang Ni, Eqra Hafeez, Dongsheng Chen · 2025 · Journal of Agricultural and Food Chemistry · DOI
Full title: Poria cocos Polysaccharide Delays Aging by Enhancing the Antioxidant Ability and Suppressing the Expression of the Branched-Chain Amino Acid Transferase-Encoding Gene in Drosophila melanogaster.
Authors: Kai Zhu, Dongsheng Du, Yuxia Shi, Fan Hu, Wenting Zhang, Hang Ni, Eqra Hafeez, Dongsheng Chen
PaperMaternal Betaine Supplementation during Gestation Enhances Expression of mtDNA-Encoded Genes through D-Loop DNA Hypomethylation in the Skeletal Muscle of Newborn Piglets.
Jia, Yimin, Song, Haogang, Gao, Guichao, Cai, Demin, Yang, Xiaojing, Zhao, Ruqian · 2015 · Journal of agricultural and food chemistry · DOI
Full title: Maternal Betaine Supplementation during Gestation Enhances Expression of mtDNA-Encoded Genes through D-Loop DNA Hypomethylation in the Skeletal Muscle of Newborn Piglets.
PaperSestrin2 Negatively Regulates Casein Synthesis through the SH3BP4-mTORC1 Pathway in Response to AA Depletion or Supplementation in Cow Mammary Epithelial Cells.
C. Luo, N. Zheng, Shengguo Zhao, Jiaqi Wang · 2019 · Journal of Agricultural and Food Chemistry · DOI
Full title: Sestrin2 Negatively Regulates Casein Synthesis through the SH3BP4-mTORC1 Pathway in Response to AA Depletion or Supplementation in Cow Mammary Epithelial Cells.
Authors: C. Luo, N. Zheng, Shengguo Zhao, Jiaqi Wang
PaperCompartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells
Pérez-Rodríguez, Saumel, Wulff, Tune, Voldborg, Björn G., Altamirano, Claudia, Trujillo‐Roldán, Mauricio A., Valdez‐Cruz, Norma A. · 2021 · ACS Omega · DOI
Full title: Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells
Authors: Pérez-Rodríguez, Saumel, Wulff, Tune, Voldborg, Björn G., Altamirano, Claudia, Trujillo‐Roldán, Mauricio A., Valdez‐Cruz, Norma A.
PaperStimulation of monoclonal antibody production of hybridoma cells by butyrate: evaluation of a feeding strategy and characterization of cell behaviour
Cherlet, Marc, Marc, A. · 2000 · Cytotechnology · DOI
Full title: Stimulation of monoclonal antibody production of hybridoma cells by butyrate: evaluation of a feeding strategy and characterization of cell behaviour
PaperThe use of peptones as medium additives for the production of a recombinant therapeutic protein in high density perfusion cultures of mammalian cells
R. Heidemann, Chun Zhang, H. Qi, James Larrick Rule, Carl Rozales, Sinyoung Park, S. Chuppa, M. Ray, J. Michaels, K. Konstantinov, D. Naveh · 2000 · Cytotechnology (Dordrecht) · DOI
Full title: The use of peptones as medium additives for the production of a recombinant therapeutic protein in high density perfusion cultures of mammalian cells
Authors: R. Heidemann, Chun Zhang, H. Qi, James Larrick Rule, Carl Rozales, Sinyoung Park, S. Chuppa, M. Ray, J. Michaels, K. Konstantinov, D. Naveh
PaperIncreased productivity of recombinant tissular plasminogen activator (t-PA) by butyrate and shift of temperature: a cell cycle phases analysis
V. Hendrick, P. Winnepenninckx, C. Abdelkafi, Olivier M. Vandeputte, M. Cherlet, T. Marique, G. Renemann, A. Loa, G. Kretzmer, J. Wérenne · 2001 · Cytotechnology (Dordrecht) · DOI
Full title: Increased productivity of recombinant tissular plasminogen activator (t-PA) by butyrate and shift of temperature: a cell cycle phases analysis
Authors: V. Hendrick, P. Winnepenninckx, C. Abdelkafi, Olivier M. Vandeputte, M. Cherlet, T. Marique, G. Renemann, A. Loa, G. Kretzmer, J. Wérenne
PaperDeciphering the determinants of recombinant protein expression across the human secretome.
Masson, Helen O, Di Giusto, Pablo, Kuo, Chih-Chung, Malm, Magdalena, Lundqvist, Magnus, Sievertsson, Åsa, Berling, Anna, Tegel, Hanna, Hober, Sophia, Uhlen, Mathias, Grassi, Luigi, Robasky, Kimberly, Hsieh, Chen-Lin, Hatton, Diane, Rockberg, Johan, Lewis, Nathan E · 2025 · Proceedings of the National Academy of Sciences of the United States of America · DOI
Full title: Deciphering the determinants of recombinant protein expression across the human secretome.
Authors: Masson, Helen O, Di Giusto, Pablo, Kuo, Chih-Chung, Malm, Magdalena, Lundqvist, Magnus, Sievertsson, Åsa, Berling, Anna, Tegel, Hanna, Hober, Sophia, Uhlen, Mathias, Grassi, Luigi, Robasky, Kimberly, Hsieh, Chen-Lin, Hatton, Diane, Rockberg, Johan, Lewis, Nathan E
Year: 2025
Venue: Proceedings of the National Academy of Sciences of the United States of America
PaperP-selectin Glycoprotein Ligand-1 and E-selectin Ligand-1 Are Differentially Modified by Fucosyltransferases Fuc-TIV and Fuc-TVII in Mouse Neutrophils
Huang, Min‐Chuan, Zöllner, Olaf, Moll, Thomas, Malý, Petr, Thall, Aron D., Lowe, John B., Vestweber, Dietmar · 2000 · Journal of Biological Chemistry · DOI
Full title: P-selectin Glycoprotein Ligand-1 and E-selectin Ligand-1 Are Differentially Modified by Fucosyltransferases Fuc-TIV and Fuc-TVII in Mouse Neutrophils
Authors: Huang, Min‐Chuan, Zöllner, Olaf, Moll, Thomas, Malý, Petr, Thall, Aron D., Lowe, John B., Vestweber, Dietmar
PaperAmino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability*
L. R. de la Ballina, Sara Cano-Crespo, Elena González-Munoz, Susanna Bial, S. Estrach, Laurence Cailleteau, Floriane S. Tissot, H. Daniel, A. Zorzano, M. Ginsberg, M. Palacín, C. Féral · 2016 · Journal of Biological Chemistry · DOI
Full title: Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability*
Authors: L. R. de la Ballina, Sara Cano-Crespo, Elena González-Munoz, Susanna Bial, S. Estrach, Laurence Cailleteau, Floriane S. Tissot, H. Daniel, A. Zorzano, M. Ginsberg, M. Palacín, C. Féral
PaperEffects of methionine and guanidinoacetic acid supplementation on performance and energy metabolites in breast muscle of male broiler chickens fed corn-soybean diets.
Majdeddin, M, Golian, A, Kermanshahi, H, Michiels, J, De Smet, S · 2019 · British poultry science · DOI
Full title: Effects of methionine and guanidinoacetic acid supplementation on performance and energy metabolites in breast muscle of male broiler chickens fed corn-soybean diets.
Authors: Majdeddin, M, Golian, A, Kermanshahi, H, Michiels, J, De Smet, S
PaperEffects of cottonseed meal bioactive peptides on growth performance, ileal digestibility, serum amino acid and immune responses of broiler chickens
M. Mohammadrezaei, B. Navidshad, A. Gheisari · 2025 · British Poultry Science · DOI
Full title: Effects of cottonseed meal bioactive peptides on growth performance, ileal digestibility, serum amino acid and immune responses of broiler chickens
Authors: M. Mohammadrezaei, B. Navidshad, A. Gheisari
PaperEffect of three probiotic Bacillus strains supplemented feeds on growth, carcass composition and blood parameters of Clarias magur (Hamilton)
Arindam Ganguly, S. Chattaraj, Mousumi Ganguly, Manasi Chattaraj, Amrita Banerjee, A. Mandal, Mohammad Muktafi Ali Khan, Sudip Kumar Sen, P. K. Das Mohapatra · 2024 · Journal of Applied Aquaculture · DOI
Full title: Effect of three probiotic Bacillus strains supplemented feeds on growth, carcass composition and blood parameters of Clarias magur (Hamilton)
Authors: Arindam Ganguly, S. Chattaraj, Mousumi Ganguly, Manasi Chattaraj, Amrita Banerjee, A. Mandal, Mohammad Muktafi Ali Khan, Sudip Kumar Sen, P. K. Das Mohapatra
Paper[Effect of the polyether antibiotic "monensin" on fattening and slaughtering performance as well as protein and energy retention in bulls].
Richter, G, Flachowsky, G, Löhnert, H J, Hennig, A · 1984 · Archiv fur Tierernahrung · DOI
Full title: [Effect of the polyether antibiotic "monensin" on fattening and slaughtering performance as well as protein and energy retention in bulls].
Authors: Richter, G, Flachowsky, G, Löhnert, H J, Hennig, A
Paper[Methodical studies of metabolism oriented methionine requirement determination in broiler chicks. 2. Effect of feeding frequency on methionine utilization].
Mnilk, B, Bergner, H, Simon, A · 1993 · Archiv fur Tierernahrung · DOI
Full title: [Methodical studies of metabolism oriented methionine requirement determination in broiler chicks. 2. Effect of feeding frequency on methionine utilization].
PaperNutrient supplementation strategy improves cell concentration and longevity, monoclonal antibody production and lactate metabolism of Chinese hamster ovary cells.
Pérez-Rodriguez, Saumel, Ramírez-Lira, María de Jesús, Trujillo-Roldán, Mauricio A, Valdez-Cruz, Norma A · 2020 · Bioengineered · DOI
Full title: Nutrient supplementation strategy improves cell concentration and longevity, monoclonal antibody production and lactate metabolism of Chinese hamster ovary cells.
Authors: Pérez-Rodriguez, Saumel, Ramírez-Lira, María de Jesús, Trujillo-Roldán, Mauricio A, Valdez-Cruz, Norma A
Paper67 Effect of Different Dietary Protein Sources on Skeletal Muscle Growth Characteristics and Satellite Cell Mitotic Activity of Young Piglets
Jorge L. Sandoval, Allan J. Calderon, Samuel F. Leiva, Brian L Anderson, J. Starkey, C. Starkey · 2023 · Journal of Animal Science · DOI
Full title: 67 Effect of Different Dietary Protein Sources on Skeletal Muscle Growth Characteristics and Satellite Cell Mitotic Activity of Young Piglets
Authors: Jorge L. Sandoval, Allan J. Calderon, Samuel F. Leiva, Brian L Anderson, J. Starkey, C. Starkey
Paper48 The impact of leucine supplementation in milk replacer on muscle proteome and metabolism in neonatal dairy calves
K. S. Safain, P. Pucetti, Júlia Travassos da Silva, Y. Entzie, J. Syring, Ellem Maria De Almeida Matos, Kendall C. Swanson · 2025 · Journal of Animal Science · DOI
Full title: 48 The impact of leucine supplementation in milk replacer on muscle proteome and metabolism in neonatal dairy calves
Authors: K. S. Safain, P. Pucetti, Júlia Travassos da Silva, Y. Entzie, J. Syring, Ellem Maria De Almeida Matos, Kendall C. Swanson
PaperDietary supplementation of short-chain fructooligosaccharides influences gastrointestinal microbiota composition and immunity characteristics of Pacific white shrimp, Litopenaeus vannamei, cultured in a recirculating system.
Li, Peng, Burr, Gary S, Gatlin, Delbert M, Hume, Michael E, Patnaik, Susmita, Castille, Frank L, Lawrence, Addison L · 2007 · The Journal of nutrition · DOI
Full title: Dietary supplementation of short-chain fructooligosaccharides influences gastrointestinal microbiota composition and immunity characteristics of Pacific white shrimp, Litopenaeus vannamei, cultured in a recirculating system.
Authors: Li, Peng, Burr, Gary S, Gatlin, Delbert M, Hume, Michael E, Patnaik, Susmita, Castille, Frank L, Lawrence, Addison L
PaperA Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and β Cells in Late-Gestation Sheep.
B. Boehmer, L. Brown, Stephanie R. Wesolowski, W. Hay, P. Rozance · 2020 · Journal of NutriLife · DOI
Full title: A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and β Cells in Late-Gestation Sheep.
Authors: B. Boehmer, L. Brown, Stephanie R. Wesolowski, W. Hay, P. Rozance
PaperFine-Tuning of Postprandial Responses via Feeding Frequency and Leucine Supplementation Affects Dietary Performance in Turbot (Scophthalmus maximus L.).
Wang, Ning, Zhang, Xuemin, Liu, Chengdong, Wang, Xuan, Zhou, Huihui, Mai, Kangsen, He, Gen · 2021 · The Journal of nutrition · DOI
Full title: Fine-Tuning of Postprandial Responses via Feeding Frequency and Leucine Supplementation Affects Dietary Performance in Turbot (Scophthalmus maximus L.).
Authors: Wang, Ning, Zhang, Xuemin, Liu, Chengdong, Wang, Xuan, Zhou, Huihui, Mai, Kangsen, He, Gen
PaperEffects of encapsulated cinnamaldehyde on growth performance, intestinal digestive and absorptive functions, meat quality and gut microbiota in broiler chickens
Chongwu Yang, M. Diarra, Janghan Choi, A. Rodas‐Gonzalez, D. Lepp, Shangxin Liu, P. Lu, Marion Mogire, Qi Wang, J. Gong, Chengbo Yang · 2021 · Translational Animal Science · DOI
Full title: Effects of encapsulated cinnamaldehyde on growth performance, intestinal digestive and absorptive functions, meat quality and gut microbiota in broiler chickens
Authors: Chongwu Yang, M. Diarra, Janghan Choi, A. Rodas‐Gonzalez, D. Lepp, Shangxin Liu, P. Lu, Marion Mogire, Qi Wang, J. Gong, Chengbo Yang
PaperZebrafish Gonadotropins and Their Receptors: II. Cloning and Characterization of Zebrafish Follicle-Stimulating Hormone and Luteinizing Hormone Subunits—Their Spatial-Temporal Expression Patterns and Receptor Specificity1
So, Wai‐Kin, Kwok, Hin-Fai, Ge, Wei · 2005 · Biology of Reproduction · DOI
Full title: Zebrafish Gonadotropins and Their Receptors: II. Cloning and Characterization of Zebrafish Follicle-Stimulating Hormone and Luteinizing Hormone Subunits—Their Spatial-Temporal Expression Patterns and Receptor Specificity1
PaperInfluence of ammonia and lysine supplementation on yeast growth and fermentation with respect to gluten‐free type brewing using unmalted sorghum grain
B. Dlamini, John R. N. Taylor, E. Buys · 2020 · International Journal of Food Science & Technology · DOI
Full title: Influence of ammonia and lysine supplementation on yeast growth and fermentation with respect to gluten‐free type brewing using unmalted sorghum grain
Authors: B. Dlamini, John R. N. Taylor, E. Buys
Year: 2020
Venue: International Journal of Food Science & Technology
PaperMolecular identification and tissue distribution of peroxisome proliferators activated receptor gamma transcript in cultured Thunnus orientalis
Y. Agawa, Tomoki Honryo, A. Ishii, Toru Kobayashi, H. Oku, Yoshifumi Sawada · 2012 · DOI
Full title: Molecular identification and tissue distribution of peroxisome proliferators activated receptor gamma transcript in cultured Thunnus orientalis
Authors: Y. Agawa, Tomoki Honryo, A. Ishii, Toru Kobayashi, H. Oku, Yoshifumi Sawada
PaperEffects of dietary supplementation of synbiotic on growth performance, serum biochemical parameters and carcass composition in rainbow trout (Oncorhynchus mykiss) fingerlings.
Mehrabi, Z, Firouzbakhsh, F, Jafarpour, A · 2012 · Journal of animal physiology and animal nutrition · DOI
Full title: Effects of dietary supplementation of synbiotic on growth performance, serum biochemical parameters and carcass composition in rainbow trout (Oncorhynchus mykiss) fingerlings.
Authors: Mehrabi, Z, Firouzbakhsh, F, Jafarpour, A
Year: 2012
Venue: Journal of animal physiology and animal nutrition
PaperEffects of dietary hydrolysate supplementation on growth, body composition, hematological responses, and liver histology of juvenile giant trevally (Caranx ignobilis Forsskal, 1775).
Nguyen, Minh Chau, Fotedar, Ravi, Pham, Hung Duc · 2024 · Journal of fish biology · DOI
Full title: Effects of dietary hydrolysate supplementation on growth, body composition, hematological responses, and liver histology of juvenile giant trevally (Caranx ignobilis Forsskal, 1775).
PaperEffects of dietary serine addition to a high plant protein diet on growth performance, body composition, hepatosomatic histological structure and metabolism of taurine synthesis in juvenile turbot (Scophthalmus maximus L.).
Qi, Guoshan, Ai, Qinghui, Jin, Xiaomin, Mu, Ye, Mai, Kangsen, Ge, Muxiang, Zhang, Wenxiang, Ren, Hai, Wang, Qinglin · 2025 · Journal of fish biology · DOI
Full title: Effects of dietary serine addition to a high plant protein diet on growth performance, body composition, hepatosomatic histological structure and metabolism of taurine synthesis in juvenile turbot (Scophthalmus maximus L.).
Authors: Qi, Guoshan, Ai, Qinghui, Jin, Xiaomin, Mu, Ye, Mai, Kangsen, Ge, Muxiang, Zhang, Wenxiang, Ren, Hai, Wang, Qinglin
PaperIron supplementation in the diets of hybrid catfish (Ictalurus punctatus × I. furcatus) juveniles affected haematocrit levels and potentially decreased disease resistance to Edwardsiella ictaluri.
Yamamoto, Fernando Y, Griffin, Matt J, Richardson, Bradley M, Stilwell, Justin M, Romano, Nicholas, Goodman, Penelope M, Reifers, J Grant, Wise, David J · 2024 · Journal of fish diseases · DOI
Full title: Iron supplementation in the diets of hybrid catfish (Ictalurus punctatus × I. furcatus) juveniles affected haematocrit levels and potentially decreased disease resistance to Edwardsiella ictaluri.
Authors: Yamamoto, Fernando Y, Griffin, Matt J, Richardson, Bradley M, Stilwell, Justin M, Romano, Nicholas, Goodman, Penelope M, Reifers, J Grant, Wise, David J
PaperPositive effects of dietary supplementation of three probiotics on milk yield, milk composition and intestinal flora in Sannan dairy goats varied in kind of probiotics.
Ma, Zhen-Zhu, Cheng, Yu-Yang, Wang, Sheng-Qi, Ge, Jian-Zhen, Shi, Huai-Ping, Kou, Jian-Cun · 2020 · Journal of animal physiology and animal nutrition · DOI
Full title: Positive effects of dietary supplementation of three probiotics on milk yield, milk composition and intestinal flora in Sannan dairy goats varied in kind of probiotics.
PaperGrowth Performance and Microbial Activity Positively Responded to Interactive Effect of Nitrogen and Phosphorus in Young Holstein Dairy Calves.
Mahmoudi, Vahid, Kazemi-Bonchenari, Mehdi, Yazdi, Mehdi Hossein, Mirzaei, Mehdi · 2025 · Journal of animal physiology and animal nutrition · DOI
Full title: Growth Performance and Microbial Activity Positively Responded to Interactive Effect of Nitrogen and Phosphorus in Young Holstein Dairy Calves.
Authors: Mahmoudi, Vahid, Kazemi-Bonchenari, Mehdi, Yazdi, Mehdi Hossein, Mirzaei, Mehdi
Year: 2025
Venue: Journal of animal physiology and animal nutrition
PaperEffects of Cerulenin upon the Syntheses of Lipid and Protein and upon the Formation of Respiratory Enzymes in Adapting, Lipid-Limited Saccharomyces cerevisiae
William Rouslin · 1979 · Journal of Bacteriology · DOI
Full title: Effects of Cerulenin upon the Syntheses of Lipid and Protein and upon the Formation of Respiratory Enzymes in Adapting, Lipid-Limited Saccharomyces cerevisiae
PaperExogenous methionine increases levels of mRNAs transcribed from pcbAB, pcbC, and cefEF genes, encoding enzymes of the cephalosporin biosynthetic pathway, in Acremonium chrysogenum
J. Velasco, S. Gutiérrez, F. J. Fernández, A. T. Marcos, C. Arenós, J. Martín · 1994 · Journal of Bacteriology · DOI
Full title: Exogenous methionine increases levels of mRNAs transcribed from pcbAB, pcbC, and cefEF genes, encoding enzymes of the cephalosporin biosynthetic pathway, in Acremonium chrysogenum
Authors: J. Velasco, S. Gutiérrez, F. J. Fernández, A. T. Marcos, C. Arenós, J. Martín
PaperGenetic mechanisms underlying feed utilization and implementation of genomic selection for improved feed efficiency in dairy cattle
Brito, Luiz F., Oliveira, Hinayah Rojas de, Houlahan, Kerry, Fonseca, Pablo Augusto de Souza, Lam, Stephanie, Butty, Adrien M., Seymour, Dave J, Vargas, G., Chud, T.C.S., Silva, Fabyano Fonseca e, Baes, Christine F., Cánovas, Ángela, Miglior, F., Schenkel, Flávio S. · 2020 · Canadian Journal of Animal Science · DOI
Full title: Genetic mechanisms underlying feed utilization and implementation of genomic selection for improved feed efficiency in dairy cattle
Authors: Brito, Luiz F., Oliveira, Hinayah Rojas de, Houlahan, Kerry, Fonseca, Pablo Augusto de Souza, Lam, Stephanie, Butty, Adrien M., Seymour, Dave J, Vargas, G., Chud, T.C.S., Silva, Fabyano Fonseca e, Baes, Christine F., Cánovas, Ángela, Miglior, F., Schenkel, Flávio S.
PaperImpact of prolonged leucine supplementation on protein synthesis and lean growth in neonatal pigs.
Columbus, Daniel A, Steinhoff-Wagner, Julia, Suryawan, Agus, Nguyen, Hanh V, Hernandez-Garcia, Adriana, Fiorotto, Marta L, Davis, Teresa A · 2015 · American journal of physiology. Endocrinology and metabolism · DOI
Full title: Impact of prolonged leucine supplementation on protein synthesis and lean growth in neonatal pigs.
Authors: Columbus, Daniel A, Steinhoff-Wagner, Julia, Suryawan, Agus, Nguyen, Hanh V, Hernandez-Garcia, Adriana, Fiorotto, Marta L, Davis, Teresa A
Year: 2015
Venue: American journal of physiology. Endocrinology and metabolism
PaperFolic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism.
Sid, Victoria, Wu, Nan, Sarna, Lindsei K, Siow, Yaw L, House, James D, O, Karmin · 2015 · American journal of physiology. Regulatory, integrative and comparative physiology · DOI
Full title: Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism.
Authors: Sid, Victoria, Wu, Nan, Sarna, Lindsei K, Siow, Yaw L, House, James D, O, Karmin
Year: 2015
Venue: American journal of physiology. Regulatory, integrative and comparative physiology
PaperDoes Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action
Humberto Nicastro, C. R. da Luz, D. F. Chaves, L. Bechara, V. Voltarelli, M. Rogero, A. Lancha · 2012 · Journal of Nutrition and Metabolism · DOI
Full title: Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action
Authors: Humberto Nicastro, C. R. da Luz, D. F. Chaves, L. Bechara, V. Voltarelli, M. Rogero, A. Lancha
PaperArginine Relieves the Inflammatory Response and Enhances the Casein Expression in Bovine Mammary Epithelial Cells Induced by Lipopolysaccharide
Tianyou Wu, Chao Wang, L. Ding, Yizhao Shen, H. Cui, Mengzhi Wang, Hongrong Wang · 2016 · Mediators of Inflammation · DOI
Full title: Arginine Relieves the Inflammatory Response and Enhances the Casein Expression in Bovine Mammary Epithelial Cells Induced by Lipopolysaccharide
Authors: Tianyou Wu, Chao Wang, L. Ding, Yizhao Shen, H. Cui, Mengzhi Wang, Hongrong Wang
PaperDietary Supplementation of L-Arginine and N-Carbamylglutamate Attenuated the Hepatic Inflammatory Response and Apoptosis in Suckling Lambs with Intrauterine Growth Retardation
Hao Zhang, Yaotian Fan, M. Elsabagh, Shuang Guo, Mengzhi Wang, Honghua Jiang · 2020 · Mediators of Inflammation · DOI
Full title: Dietary Supplementation of L-Arginine and N-Carbamylglutamate Attenuated the Hepatic Inflammatory Response and Apoptosis in Suckling Lambs with Intrauterine Growth Retardation
PaperEvaluation of the Role of Soybean Lecithin, Egg Yolk Lecithin, and Krill Oil in Promoting Ovarian Development in the Female Redclaw Crayfish Cherax quadricarinatus.
Full title: Evaluation of the Role of Soybean Lecithin, Egg Yolk Lecithin, and Krill Oil in Promoting Ovarian Development in the Female Redclaw Crayfish Cherax quadricarinatus.
PaperEvaluation of Dietary Essential Amino Acid Supplementation on Growth, Digestive Capacity, Antioxidant, and Intestine Health of the Juvenile Redclaw Crayfish, <i>Cherax quadricarinatus</i>
Full title: Evaluation of Dietary Essential Amino Acid Supplementation on Growth, Digestive Capacity, Antioxidant, and Intestine Health of the Juvenile Redclaw Crayfish, <i>Cherax quadricarinatus</i>
PaperBetaine Supplementation Into High-Carbohydrate Diets Improves Feed Efficiency and Liver Health of Megalobrama amblycephala by Increasing Taurine Synthesis.
Full title: Betaine Supplementation Into High-Carbohydrate Diets Improves Feed Efficiency and Liver Health of Megalobrama amblycephala by Increasing Taurine Synthesis.
PaperOptimization of recombinant antibody production based on the vector design and the level of metabolites for generation of Ig- producing stable cell lines
Топорова, В. А., Аргентова, В. В., Алиев, Т. К., Панина, А. А., Долгих, Д. А., Кирпичников, М. П. · 2023 · Journal of Genetic Engineering and Biotechnology · DOI
Full title: Optimization of recombinant antibody production based on the vector design and the level of metabolites for generation of Ig- producing stable cell lines
Authors: Топорова, В. А., Аргентова, В. В., Алиев, Т. К., Панина, А. А., Долгих, Д. А., Кирпичников, М. П.
Year: 2023
Venue: Journal of Genetic Engineering and Biotechnology
PaperThe Human Growth Hormone (GH) Receptor and Its Truncated Isoform: Sulfhydryl Group Inactivation in the Study of Receptor Internalization and GH-Binding Protein Generation
Full title: The Human Growth Hormone (GH) Receptor and Its Truncated Isoform: Sulfhydryl Group Inactivation in the Study of Receptor Internalization and GH-Binding Protein Generation
PaperEffect of zinc supplementation from different sources on growth, nutrient digestibility, blood metabolic profile, and immune response of male Guinea pigs.
Shinde, Prashant, Dass, Ram Sharan, Garg, Anil Kumar, Chaturvedi, Vinod Kumar, Kumar, Ripusudan · 2006 · Biological trace element research · DOI
Full title: Effect of zinc supplementation from different sources on growth, nutrient digestibility, blood metabolic profile, and immune response of male Guinea pigs.
PaperFACTORS AFFECTING CHINESE HAMSTER OVARY CELL PROLIFERATION AND VIABILITY
Reķēna, Alīna, Livkisa, Dora, Loča, Dagnija · 2019 · Environment Technology Resources Proceedings of the International Scientific and Practical Conference · DOI
Full title: FACTORS AFFECTING CHINESE HAMSTER OVARY CELL PROLIFERATION AND VIABILITY
PaperUpdated transient gene expression protocol and the development of a small-scale transient gene expression protocol -evaluated by testing of longevity molecules as potential protein expression enhancers
Rosa, Andrés de la, Petrovic, Alex, Godec, Ana, Napoleone, Antonino, Metzendorf, Nicole G., Hultqvist, Greta · 2023 · Research Square (Research Square) · DOI
Full title: Updated transient gene expression protocol and the development of a small-scale transient gene expression protocol -evaluated by testing of longevity molecules as potential protein expression enhancers
Authors: Rosa, Andrés de la, Petrovic, Alex, Godec, Ana, Napoleone, Antonino, Metzendorf, Nicole G., Hultqvist, Greta
PaperEffects of dietary N-carbamylglutamate supplementation on milk production performance, nutrient digestibility and blood metabolomics of lactating Holstein cows under heat stress
Ning Ma, Yan Li, L. Ren, Linqi Hu, Ruiting Xu, Yizhao Shen, Yufeng Cao, Yanxia Gao, Jianguo Li · 2020 · Animal Feed Science and Technology · DOI
Full title: Effects of dietary N-carbamylglutamate supplementation on milk production performance, nutrient digestibility and blood metabolomics of lactating Holstein cows under heat stress
Authors: Ning Ma, Yan Li, L. Ren, Linqi Hu, Ruiting Xu, Yizhao Shen, Yufeng Cao, Yanxia Gao, Jianguo Li
PaperMitochondrial Hyperfusion Via Metabolic Sensing of Regulatory Amino Acids
Mahmud O. Abdullah, Run X. Zeng, Mohammad Al-Rofaidi, N. Al-Tannak, Nicholas Rattray, E. Eskelinen, David G. Watson, Edmond Y W Chan · 2020 · Social Science Research Network · DOI
Full title: Mitochondrial Hyperfusion Via Metabolic Sensing of Regulatory Amino Acids
Authors: Mahmud O. Abdullah, Run X. Zeng, Mohammad Al-Rofaidi, N. Al-Tannak, Nicholas Rattray, E. Eskelinen, David G. Watson, Edmond Y W Chan
PaperLactate Control Enhances Growth Advantage in Fed-batch Cultures of Metabolically Engineered CHO Cells with Reduced Novel Growth-inhibitory Compound Formation
Full title: Lactate Control Enhances Growth Advantage in Fed-batch Cultures of Metabolically Engineered CHO Cells with Reduced Novel Growth-inhibitory Compound Formation
PaperUsing MVDA with Stoichiometric Balances to Optimize Amino Acid Concentrations in Chemically Defined CHO Cell Culture Medium for Improved Culture Performance
Salim, Taha, Chauhan, Gaurav, Templeton, Neil, Ling, Wai Lam W. · 2021 · DOI
Full title: Using MVDA with Stoichiometric Balances to Optimize Amino Acid Concentrations in Chemically Defined CHO Cell Culture Medium for Improved Culture Performance
PaperIntracellular CHO cell metabolite profiling and in vivo monitoring of redox state unravel the effect of temperature downshift on cell growth, antibody titer and product quality
Full title: Intracellular CHO cell metabolite profiling and in vivo monitoring of redox state unravel the effect of temperature downshift on cell growth, antibody titer and product quality
PaperInfluence of dietary supplementation with (L)-carnitine on metabolic rate, fatty acid oxidation, body condition, and weight loss in overweight cats.
Center, Sharon A, Warner, Karen L, Randolph, John F, Sunvold, Gregory D, Vickers, Jason R · 2012 · American journal of veterinary research · DOI
Full title: Influence of dietary supplementation with (L)-carnitine on metabolic rate, fatty acid oxidation, body condition, and weight loss in overweight cats.
Authors: Center, Sharon A, Warner, Karen L, Randolph, John F, Sunvold, Gregory D, Vickers, Jason R
PaperEffects of corn grinding and time of corn feeding on growth, starch utilization and digesta passage characteristics of growing steers fed hay-based diets.
Leonard, E S, Pond, K R, Harvey, R W, Crickenberger, R G · 1989 · Journal of animal science · DOI
Full title: Effects of corn grinding and time of corn feeding on growth, starch utilization and digesta passage characteristics of growing steers fed hay-based diets.
Authors: Leonard, E S, Pond, K R, Harvey, R W, Crickenberger, R G
PaperDietary supplementation of conjugated linoleic acid in horses increases plasma conjugated linoleic acid and decreases plasma arachidonic acid but does not alter body fat.
Headley, S, Coverdale, J A, Jenkins, T C, Klein, C M, Sharp, J L, Vernon, K L · 2012 · Journal of animal science · DOI
Full title: Dietary supplementation of conjugated linoleic acid in horses increases plasma conjugated linoleic acid and decreases plasma arachidonic acid but does not alter body fat.
Authors: Headley, S, Coverdale, J A, Jenkins, T C, Klein, C M, Sharp, J L, Vernon, K L
PaperEffects of feed grade L-methionine on intestinal redox status, intestinal development, and growth performance of young chickens compared with conventional DL-methionine
Shen, Y. B., Ferket, P.R., Park, I., Malheiros, Ramon D., Kim, Sung Woo · 2015 · Journal of Animal Science · DOI
Full title: Effects of feed grade L-methionine on intestinal redox status, intestinal development, and growth performance of young chickens compared with conventional DL-methionine
Authors: Shen, Y. B., Ferket, P.R., Park, I., Malheiros, Ramon D., Kim, Sung Woo
PaperTranscriptomic signature of high dietary organic selenium supplementation in sheep: A nutrigenomic insight using a custom microarray platform and gene set enrichment analysis.
Elgendy, R, Giantin, M, Castellani, F, Grotta, L, Palazzo, F, Dacasto, M, Martino, G · 2016 · Journal of animal science · DOI
Full title: Transcriptomic signature of high dietary organic selenium supplementation in sheep: A nutrigenomic insight using a custom microarray platform and gene set enrichment analysis.
Authors: Elgendy, R, Giantin, M, Castellani, F, Grotta, L, Palazzo, F, Dacasto, M, Martino, G
PaperExploration of peroxisome proliferator-exploration of peroxisome proliferator-activated receptor gamma agonist in Alzheimer’s disease therapy – a therapeutic enigma
Chang, Kai · 2014 · Spiral (Imperial College London) · DOI
Full title: Exploration of peroxisome proliferator-exploration of peroxisome proliferator-activated receptor gamma agonist in Alzheimer’s disease therapy – a therapeutic enigma
Paper- **DOI:** 10.25687/1996-6733.prodanimbiol.2018.3.65-74 - **Authors:** Макар З.Н., Черепанов Г.Г. - **Year:** 2018 - **Journal:** Проблемы биологии продуктивных животных
Макар З.Н., Черепанов Г.Г. · 2018 · Проблемы биологии продуктивных животных · DOI
Full title: - **DOI:** 10.25687/1996-6733.prodanimbiol.2018.3.65-74 - **Authors:** Макар З.Н., Черепанов Г.Г. - **Year:** 2018 - **Journal:** Проблемы биологии продуктивных животных
PaperSafety and efficacy of l‐arginine produced by fermentation using Corynebacterium glutamicum KCCM 10741P for all animal species
G. Rychen, G. Aquilina, Giovanna Azimonti, V. Bampidis, M. Bastos, G. Bories, A. Chesson, P. Cocconcelli, G. Flachowsky, J. Gropp, B. Kolar, M. Kouba, M. López-Alonso, Secundino López Puente, A. Mantovani, B. Mayo, F. Ramos, M. Saarela, R. Villa, P. Wester, L. Costa, N. Dierick, L. Leng, J. Tárres‐Call, R. Wallace · 2018 · EFSA journal. European Food Safety Authority · DOI
Full title: Safety and efficacy of l‐arginine produced by fermentation using Corynebacterium glutamicum KCCM 10741P for all animal species
Authors: G. Rychen, G. Aquilina, Giovanna Azimonti, V. Bampidis, M. Bastos, G. Bories, A. Chesson, P. Cocconcelli, G. Flachowsky, J. Gropp, B. Kolar, M. Kouba, M. López-Alonso, Secundino López Puente, A. Mantovani, B. Mayo, F. Ramos, M. Saarela, R. Villa, P. Wester, L. Costa, N. Dierick, L. Leng, J. Tárres‐Call, R. Wallace
Year: 2018
Venue: EFSA journal. European Food Safety Authority
PaperCombination of histidine, lysine, methionine, and leucine promotes β-casein synthesis via the mechanistic target of rapamycin signaling pathway in bovine mammary epithelial cells.
Huijun Gao, Shengguo Zhao, N. Zheng, Yangdong Zhang, S. Wang, X. Q. Zhou, Jiaqi Wang · 2017 · Journal of Dairy Science · DOI
Full title: Combination of histidine, lysine, methionine, and leucine promotes β-casein synthesis via the mechanistic target of rapamycin signaling pathway in bovine mammary epithelial cells.
Authors: Huijun Gao, Shengguo Zhao, N. Zheng, Yangdong Zhang, S. Wang, X. Q. Zhou, Jiaqi Wang
PaperIncreasing the availability of threonine, isoleucine, valine, and leucine relative to lysine while maintaining an ideal ratio of lysine:methionine alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription
Dong, Xianwen, Zhou, Zhen, Wang, L., Saremi, B., Helmbrecht, A., Wang, Z., Loor, Juan J. · 2018 · Journal of Dairy Science · DOI
Full title: Increasing the availability of threonine, isoleucine, valine, and leucine relative to lysine while maintaining an ideal ratio of lysine:methionine alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription
Authors: Dong, Xianwen, Zhou, Zhen, Wang, L., Saremi, B., Helmbrecht, A., Wang, Z., Loor, Juan J.
PaperMethionine and valine activate the mammalian target of rapamycin complex 1 pathway through heterodimeric amino acid taste receptor (TAS1R1/TAS1R3) and intracellular Ca2+ in bovine mammary epithelial cells.
Y. Zhou, Z. Zhou, J. Peng, J. Loor · 2018 · Journal of Dairy Science · DOI
Full title: Methionine and valine activate the mammalian target of rapamycin complex 1 pathway through heterodimeric amino acid taste receptor (TAS1R1/TAS1R3) and intracellular Ca2+ in bovine mammary epithelial cells.
PaperNutrient-sensing kinase signaling in bovine immune cells is altered during the postpartum nutrient deficit: A possible role in transition cow inflammatory response.
S. Mann, A. Sipka, F. L. Leal Yepes, D. Nydam, T. Overton, J. Wakshlag · 2018 · Journal of Dairy Science · DOI
Full title: Nutrient-sensing kinase signaling in bovine immune cells is altered during the postpartum nutrient deficit: A possible role in transition cow inflammatory response.
Authors: S. Mann, A. Sipka, F. L. Leal Yepes, D. Nydam, T. Overton, J. Wakshlag
PaperEffect of dietary supplementation or cessation of magnesium-based alkalizers on milk fat output in dairy cows under milk fat depression conditions.
Razzaghi, A, Vakili, A R, Khorrami, B, Ghaffari, M H, Rico, D E · 2022 · Journal of dairy science · DOI
Full title: Effect of dietary supplementation or cessation of magnesium-based alkalizers on milk fat output in dairy cows under milk fat depression conditions.
Authors: Razzaghi, A, Vakili, A R, Khorrami, B, Ghaffari, M H, Rico, D E
PaperEffects of branched-chain amino acids on glucose uptake and lactose synthesis rates in bovine mammary epithelial cells and lactating mammary tissue slices.
J.V.V. Silva, S. Ganesan, H. Wickramasinghe, N. Stepanchenko, C. Kaya, D. Beitz, J. Appuhamy · 2021 · Journal of Dairy Science · DOI
Full title: Effects of branched-chain amino acids on glucose uptake and lactose synthesis rates in bovine mammary epithelial cells and lactating mammary tissue slices.
Authors: J.V.V. Silva, S. Ganesan, H. Wickramasinghe, N. Stepanchenko, C. Kaya, D. Beitz, J. Appuhamy
PaperEffects of hydrogen peroxide and l-tryptophan on antioxidative potential, apoptosis, and mammalian target of rapamycin signaling in bovine intestinal epithelial cells.
Xiaoshi Wei, Dongping Li, Changdong Feng, H. Mao, Jinpeng Zhu, Yanjun Cui, Jinyong Yang, Hui Gao, Chong Wang · 2022 · Journal of Dairy Science · DOI
Full title: Effects of hydrogen peroxide and l-tryptophan on antioxidative potential, apoptosis, and mammalian target of rapamycin signaling in bovine intestinal epithelial cells.
Authors: Xiaoshi Wei, Dongping Li, Changdong Feng, H. Mao, Jinpeng Zhu, Yanjun Cui, Jinyong Yang, Hui Gao, Chong Wang
PaperMeta-analysis of the effects of supplemental leucine alone or in combination with other branched-chain amino acids on lactational performance in dairy cows and the associated influencing factors.
Wang, Xiaowen, Sun, Mengxu, Hu, Zhisheng, Zhan, Hengrui, Bu, Dengpan, Xu, Lianbin · 2025 · Journal of dairy science · DOI
Full title: Meta-analysis of the effects of supplemental leucine alone or in combination with other branched-chain amino acids on lactational performance in dairy cows and the associated influencing factors.
PaperA hierarchical 3-level meta-analysis of the effects of supplemental histidine on lactational performance in dairy cows and the associated influencing factors.
Xu, Lianbin, He, Minjia, Wang, Jianhua, Li, Peipei, Wang, Yijian, Wang, Xiaowen, Bu, Dengpan · 2026 · Journal of dairy science · DOI
Full title: A hierarchical 3-level meta-analysis of the effects of supplemental histidine on lactational performance in dairy cows and the associated influencing factors.
PaperA hierarchical 3-level meta-analysis of the effect of arginine supplementation on lactational performance in dairy cows and the associated influencing factors.
Li, Xiuli, Wang, Xiaowen, Sun, Le, He, Minjia, Wang, Luzhen, Bu, Dengpan, Xu, Lianbin · 2026 · Journal of dairy science · DOI
Full title: A hierarchical 3-level meta-analysis of the effect of arginine supplementation on lactational performance in dairy cows and the associated influencing factors.
Authors: Li, Xiuli, Wang, Xiaowen, Sun, Le, He, Minjia, Wang, Luzhen, Bu, Dengpan, Xu, Lianbin
PaperImpacts of feeding milk replacer supplemented with increasing concentrations of choline on feed intake, growth, and scouring incidence for 7 weeks preweaning and 1 week postweaning.
Ravelo, Anay D, Dufour, Ellan I, Klejeski, Makaila, Ziegler, Bruce, Golombeski, Angie, Salfer, Isaac J · 2024 · JDS communications · DOI
Full title: Impacts of feeding milk replacer supplemented with increasing concentrations of choline on feed intake, growth, and scouring incidence for 7 weeks preweaning and 1 week postweaning.
Authors: Ravelo, Anay D, Dufour, Ellan I, Klejeski, Makaila, Ziegler, Bruce, Golombeski, Angie, Salfer, Isaac J
PaperNitrogen supplementation of corn silages. 1. Effects on feed intake and milk production of dairy cows.
Cabrita, A R J, Fonseca, A J M, Dewhurst, R J, Sampaio, C V P, Miranda, M F S, Sousa, G N S, Miranda, I M F, Gomes, E · 2003 · Journal of dairy science · DOI
Full title: Nitrogen supplementation of corn silages. 1. Effects on feed intake and milk production of dairy cows.
Authors: Cabrita, A R J, Fonseca, A J M, Dewhurst, R J, Sampaio, C V P, Miranda, M F S, Sousa, G N S, Miranda, I M F, Gomes, E
PaperMammalian Cell Line Development Platform for Recombinant Protein Production: Expanding the Protein Expression Toolbox for Research and Drug Discovery Applications
Full title: Mammalian Cell Line Development Platform for Recombinant Protein Production: Expanding the Protein Expression Toolbox for Research and Drug Discovery Applications
PaperL-arginine upregulates the gene expression of target of rapamycin signaling pathway and stimulates protein synthesis in chicken intestinal epithelial cells.
C. Yuan, Y. Ding, Qiang He, M. Azzam, J. Lu, X. Zou · 2015 · Poultry Science · DOI
Full title: L-arginine upregulates the gene expression of target of rapamycin signaling pathway and stimulates protein synthesis in chicken intestinal epithelial cells.
Authors: C. Yuan, Y. Ding, Qiang He, M. Azzam, J. Lu, X. Zou
PaperEffects of Dietary Supplementation of Lauric Acid on Lactation Function, Mammary Gland Development, and Serum Lipid Metabolites in Lactating Mice.
Yang, Lin, Yang, Qiang, Li, Fan, Yi, Wuzhou, Liu, Fangfang, Wang, Songbo, Jiang, Qingyan · 2020 · Animals : an open access journal from MDPI · DOI
Full title: Effects of Dietary Supplementation of Lauric Acid on Lactation Function, Mammary Gland Development, and Serum Lipid Metabolites in Lactating Mice.
PaperToo Much of a Good Thing: Rethinking Feed Formulation and Feeding Practices for Zinc in Swine Diets to Achieve One Health and Environmental Sustainability.
Shurson, Gerald C, Urriola, Pedro E, Hung, Yuan-Tai · 2022 · Animals : an open access journal from MDPI · DOI
Full title: Too Much of a Good Thing: Rethinking Feed Formulation and Feeding Practices for Zinc in Swine Diets to Achieve One Health and Environmental Sustainability.
Authors: Shurson, Gerald C, Urriola, Pedro E, Hung, Yuan-Tai
PaperEffects of Dietary Glycine Supplementation on Growth Performance, Immunological, and Erythrocyte Antioxidant Parameters in Common Carp, Cyprinus carpio.
Abbasi, Marzieh, Taheri Mirghaed, Ali, Hoseini, Seyyed Morteza, Rajabiesterabadi, Hamid, Hoseinifar, Seyed Hossein, Van Doan, Hien · 2023 · Animals : an open access journal from MDPI · DOI
Full title: Effects of Dietary Glycine Supplementation on Growth Performance, Immunological, and Erythrocyte Antioxidant Parameters in Common Carp, Cyprinus carpio.
Authors: Abbasi, Marzieh, Taheri Mirghaed, Ali, Hoseini, Seyyed Morteza, Rajabiesterabadi, Hamid, Hoseinifar, Seyed Hossein, Van Doan, Hien
PaperEffects of Protein Supplementation Strategy and Genotype on Milk Production and Nitrogen Utilisation Efficiency in Late-Lactation, Spring-Calving Grazing Dairy Cows.
Doran, M J, Mulligan, Finbar J, Lynch, Mary B, Fahey, Alan G, Markiewicz-Keszycka, Maria, Rajauria, Gaurav, Pierce, Karina M · 2023 · Animals : an open access journal from MDPI · DOI
Full title: Effects of Protein Supplementation Strategy and Genotype on Milk Production and Nitrogen Utilisation Efficiency in Late-Lactation, Spring-Calving Grazing Dairy Cows.
Authors: Doran, M J, Mulligan, Finbar J, Lynch, Mary B, Fahey, Alan G, Markiewicz-Keszycka, Maria, Rajauria, Gaurav, Pierce, Karina M
PaperUtilization of Cottonseed Meal Protein Hydrolysate by Crustaceans: Insights on Growth Performance, Protein Turnover, and Metabolism in Chinese Mitten Crab Eriocheir sinensis
Full title: Utilization of Cottonseed Meal Protein Hydrolysate by Crustaceans: Insights on Growth Performance, Protein Turnover, and Metabolism in Chinese Mitten Crab Eriocheir sinensis
PaperQuantitative Proteomics Revealed the Molecular Regulatory Network of Lysine and the Effects of Lysine Supplementation on Sunit Skeletal Muscle Satellite Cells
Mingxu Wang, Fan Bai, Qinan Zhao, Jianan Shi, Yutian Hao, Jindi Wu · 2025 · Animals · DOI
Full title: Quantitative Proteomics Revealed the Molecular Regulatory Network of Lysine and the Effects of Lysine Supplementation on Sunit Skeletal Muscle Satellite Cells
PaperLong-Term Feeding with Curcumin Affects the Growth, Antioxidant Capacity, Immune Status, Tissue Histoarchitecture, Immune Expression of Proinflammatory Cytokines, and Apoptosis Indicators in Nile Tilapia, Oreochromis niloticus.
Amer, Shimaa A, El-Araby, Doaa A, Tartor, Haitham, Farahat, Mahmoud, Goda, Nehal I A, Farag, Mohamed F M, Fahmy, Esraa M, Hassan, Aziza M, Abo El-Maati, Mohamed F, Osman, Ali · 2022 · Antioxidants (Basel, Switzerland) · DOI
Full title: Long-Term Feeding with Curcumin Affects the Growth, Antioxidant Capacity, Immune Status, Tissue Histoarchitecture, Immune Expression of Proinflammatory Cytokines, and Apoptosis Indicators in Nile Tilapia, Oreochromis niloticus.
Authors: Amer, Shimaa A, El-Araby, Doaa A, Tartor, Haitham, Farahat, Mahmoud, Goda, Nehal I A, Farag, Mohamed F M, Fahmy, Esraa M, Hassan, Aziza M, Abo El-Maati, Mohamed F, Osman, Ali
PaperEffects of Dietary Inosine 5'-Monophosphate Supplementation on the Growth Performance and Salinity and Oxidative Stress Resistance of Gibel Carp (Carassius auratus gibelio).
Full title: Effects of Dietary Inosine 5'-Monophosphate Supplementation on the Growth Performance and Salinity and Oxidative Stress Resistance of Gibel Carp (Carassius auratus gibelio).
PaperDeciphering Metabolic Pathways in High-Seeding-Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective.
Full title: Deciphering Metabolic Pathways in High-Seeding-Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective.
PaperAdvances in Escherichia coli-Based Therapeutic Protein Expression: Mammalian Conversion, Continuous Manufacturing, and Cell-Free Production
Niazi, Sarfaraz K., Magoola, Matthias · 2023 · Biologics · DOI
Full title: Advances in Escherichia coli-Based Therapeutic Protein Expression: Mammalian Conversion, Continuous Manufacturing, and Cell-Free Production
Full title: Dietary Tryptophan Plays a Role as an Anti-Inflammatory Agent in European Seabass (Dicentrarchus labrax) Juveniles during Chronic Inflammation.
PaperThe Effect of β-Carotene, Tocopherols and Ascorbic Acid as Anti-Oxidant Molecules on Human and Animal In Vitro/In Vivo Studies: A Review of Research Design and Analytical Techniques Used
Full title: The Effect of β-Carotene, Tocopherols and Ascorbic Acid as Anti-Oxidant Molecules on Human and Animal In Vitro/In Vivo Studies: A Review of Research Design and Analytical Techniques Used
PaperLeucine-Rich Diet Modulates the Metabolomic and Proteomic Profile of Skeletal Muscle during Cancer Cachexia
B. Cruz, André Gustavo Oliveira, L. Viana, L. Lopes‐Aguiar, Rafael Canevarolo, Maiara Caroline Colombera, Rafael R Valentim, Fernanda Garcia-Fossa, L. M. de Sousa, B. Castelucci, S. Consonni, D. Martins‐de‐Souza, M. D. de Jesus, S. Russell, Maria Cristina Cintra Gomes-Mardondes · 2020 · Cancers · DOI
Full title: Leucine-Rich Diet Modulates the Metabolomic and Proteomic Profile of Skeletal Muscle during Cancer Cachexia
Authors: B. Cruz, André Gustavo Oliveira, L. Viana, L. Lopes‐Aguiar, Rafael Canevarolo, Maiara Caroline Colombera, Rafael R Valentim, Fernanda Garcia-Fossa, L. M. de Sousa, B. Castelucci, S. Consonni, D. Martins‐de‐Souza, M. D. de Jesus, S. Russell, Maria Cristina Cintra Gomes-Mardondes
PaperDietary Supplementation of a Mixture of Nucleotides, β-Glucan and Vitamins C and E Improved the Growth and Health Performance of Olive Flounder, Paralichthys olivaceus
Full title: Dietary Supplementation of a Mixture of Nucleotides, β-Glucan and Vitamins C and E Improved the Growth and Health Performance of Olive Flounder, Paralichthys olivaceus
Full title: Transcriptome Analysis Suggests Dietary Tributyrin Enhances Feeding Intensity via Modulating Steroid Biosynthesis in Mandarin Fish (Siniperca chuatsi).
PaperStudies to Prevent Degradation of Recombinant Fc-Fusion Protein Expressed in Mammalian Cell Line and Protein Characterization
Chakrabarti, Sanjukta, Barrow, Colin J., Kanwar, Jagat R., Ramana, Venkata, Kanwar, Jagat R. · 2016 · International Journal of Molecular Sciences · DOI
Full title: Studies to Prevent Degradation of Recombinant Fc-Fusion Protein Expressed in Mammalian Cell Line and Protein Characterization
Authors: Chakrabarti, Sanjukta, Barrow, Colin J., Kanwar, Jagat R., Ramana, Venkata, Kanwar, Jagat R.
Year: 2016
Venue: International Journal of Molecular Sciences
PaperComputer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms
Traustason, Bergthor, Cheeks, Matthew, Dikicioǧlu, Duygu · 2019 · International Journal of Molecular Sciences · DOI
Full title: Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms
PaperEffects of Tyrosine and Tryptophan in Rats with Diet-Induced Obesity
V. Shipelin, N. Trusov, S. Apryatin, A. Shumakova, Anastasia S Balakina, N. Riger, I. Gmoshinski, D. B. Nikityuk · 2021 · International Journal of Molecular Sciences · DOI
Full title: Effects of Tyrosine and Tryptophan in Rats with Diet-Induced Obesity
Authors: V. Shipelin, N. Trusov, S. Apryatin, A. Shumakova, Anastasia S Balakina, N. Riger, I. Gmoshinski, D. B. Nikityuk
Year: 2021
Venue: International Journal of Molecular Sciences
PaperAre the Main Methionine Sources Equivalent? A Focus on DL-Methionine and DL-Methionine Hydroxy Analog Reveals Differences on Rainbow Trout Hepatic Cell Lines Functions
Karine Pinel, C. Heraud, G. Morin, K. Dias, A. Marcé, L. Beauclair, S. Fontagné-Dicharry, K. Masagounder, M. Klünemann, I. Seiliez, F. Beaumatin · 2022 · International Journal of Molecular Sciences · DOI
Full title: Are the Main Methionine Sources Equivalent? A Focus on DL-Methionine and DL-Methionine Hydroxy Analog Reveals Differences on Rainbow Trout Hepatic Cell Lines Functions
Authors: Karine Pinel, C. Heraud, G. Morin, K. Dias, A. Marcé, L. Beauclair, S. Fontagné-Dicharry, K. Masagounder, M. Klünemann, I. Seiliez, F. Beaumatin
Year: 2022
Venue: International Journal of Molecular Sciences
PaperIntegrated Transcriptomic Analyses of Liver and Mammary Gland Tissues Reveals the Regulatory Mechanism Underlying Dairy Goats at Late Lactation When Feeding Rumen-Protected Lysine.
Dai, Wenting, Han, Bingqing, Sun, Yalu, Hou, Pengfei, Wang, Chong, Li, Weini, Liu, Hongyun · 2024 · International journal of molecular sciences · DOI
Full title: Integrated Transcriptomic Analyses of Liver and Mammary Gland Tissues Reveals the Regulatory Mechanism Underlying Dairy Goats at Late Lactation When Feeding Rumen-Protected Lysine.
PaperEffect of Supplementing Lysine and Isoleucine as Limiting Amino Acids on Growth Performance and Amino Acid Deposition of Tenebrio molitor Larvae Reared on a Cereal-Based Substrate.
Fondevila, Guillermo, Fatmi, Habib, Fernando, Pilar, Dapoza, Carlos, Fondevila, Manuel · 2025 · Insects · DOI
Full title: Effect of Supplementing Lysine and Isoleucine as Limiting Amino Acids on Growth Performance and Amino Acid Deposition of Tenebrio molitor Larvae Reared on a Cereal-Based Substrate.
PaperEnhancing Metabolism and Milk Production Performance in Periparturient Dairy Cattle through Rumen-Protected Methionine and Choline Supplementation.
Huang, Bingjian, Khan, Muhammad Zahoor, Kou, Xiyan, Chen, Yinghui, Liang, Huili, Ullah, Qudrat, Khan, Nadar, Khan, Adnan, Chai, Wenqiong, Wang, Changfa · 2023 · Metabolites · DOI
Full title: Enhancing Metabolism and Milk Production Performance in Periparturient Dairy Cattle through Rumen-Protected Methionine and Choline Supplementation.
Authors: Huang, Bingjian, Khan, Muhammad Zahoor, Kou, Xiyan, Chen, Yinghui, Liang, Huili, Ullah, Qudrat, Khan, Nadar, Khan, Adnan, Chai, Wenqiong, Wang, Changfa
PaperEffects of Supplementation of Branched-Chain Amino Acids to Reduced-Protein Diet on Skeletal Muscle Protein Synthesis and Degradation in the Fed and Fasted States in a Piglet Model.
Full title: Effects of Supplementation of Branched-Chain Amino Acids to Reduced-Protein Diet on Skeletal Muscle Protein Synthesis and Degradation in the Fed and Fasted States in a Piglet Model.
PaperProduction of a Dulaglutide Analogue by Apoptosis-Resistant Chinese Hamster Ovary Cells in a 3-Week Fed-Batch Process.
Shaifutdinov, Rolan R, Sinegubova, Maria V, Vorobiev, Ivan I, Prokhorova, Polina E, Podkorytov, Alexey B, Orlova, Nadezhda A · 2025 · Pharmaceuticals (Basel, Switzerland) · DOI
Full title: Production of a Dulaglutide Analogue by Apoptosis-Resistant Chinese Hamster Ovary Cells in a 3-Week Fed-Batch Process.
Authors: Shaifutdinov, Rolan R, Sinegubova, Maria V, Vorobiev, Ivan I, Prokhorova, Polina E, Podkorytov, Alexey B, Orlova, Nadezhda A
PaperFecal Microbiota and Performance of Dairy Cattle from a West Mexican Family Dairy Farm Supplemented with a Fiber-Degrading Enzymatic Complex.
Ruvalcaba-Gómez, José Martín, Arteaga-Garibay, Ramón Ignacio, Anaya-Esparza, Luis Miguel, Gómez-Godínez, Lorena Jacqueline, Martínez-Sotelo, Jazmín Guadalupe, Hernández-Cruz, Elías, Arias-Chávez, Luis Eduardo · 2025 · Veterinary sciences · DOI
Full title: Fecal Microbiota and Performance of Dairy Cattle from a West Mexican Family Dairy Farm Supplemented with a Fiber-Degrading Enzymatic Complex.
Authors: Ruvalcaba-Gómez, José Martín, Arteaga-Garibay, Ramón Ignacio, Anaya-Esparza, Luis Miguel, Gómez-Godínez, Lorena Jacqueline, Martínez-Sotelo, Jazmín Guadalupe, Hernández-Cruz, Elías, Arias-Chávez, Luis Eduardo
PaperPurification and Analytics of a Monoclonal Antibody from Chinese Hamster Ovary Cells Using an Automated Microbioreactor System
Velugula‐Yellela, Sai Rashmika, Powers, David N., Angart, Phillip, Faustino, Anneliese M., Faison, Talia, Kohnhorst, Casey, Fratz‐Berilla, Erica J., Agarabi, Cyrus · 2019 · Journal of Visualized Experiments · DOI
Full title: Purification and Analytics of a Monoclonal Antibody from Chinese Hamster Ovary Cells Using an Automated Microbioreactor System
Authors: Velugula‐Yellela, Sai Rashmika, Powers, David N., Angart, Phillip, Faustino, Anneliese M., Faison, Talia, Kohnhorst, Casey, Fratz‐Berilla, Erica J., Agarabi, Cyrus
PaperLeucine supplementation of a low-protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR-dependent translation initiation.
Murgas Torrazza, Roberto, Suryawan, Agus, Gazzaneo, Maria C, Orellana, Renán A, Frank, Jason W, Nguyen, Hanh V, Fiorotto, Marta L, El-Kadi, Samer, Davis, Teresa A · 2010 · The Journal of nutrition · DOI
Full title: Leucine supplementation of a low-protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR-dependent translation initiation.
Authors: Murgas Torrazza, Roberto, Suryawan, Agus, Gazzaneo, Maria C, Orellana, Renán A, Frank, Jason W, Nguyen, Hanh V, Fiorotto, Marta L, El-Kadi, Samer, Davis, Teresa A
PaperMetabolic status, reproductive, and productive performances of transition dairy cows as affected by dietary rumen-protected choline supplementation.
Lunsin, Ratchataporn, Sokantat, Damrongchai, Silvestre, Taina, Neto, Helio Rezende Lima, Koh, Thong Jin, Sun, Fei, Yeanpet, Chittraporn, Pilajun, Ruangyote · 2024 · Journal of advanced veterinary and animal research · DOI
Full title: Metabolic status, reproductive, and productive performances of transition dairy cows as affected by dietary rumen-protected choline supplementation.
PaperPotential of growth factors and steroid hormones from cell cultures to improve in vitro fertilization in bovine
Sri Mulyati, F. Rantam, A. Khairullah, Imam Mustofa, A. Akintunde, R. Ahmad, Ulvi Fitri Handayani, A. Khalisa, Lili Anggraini, Bima Putra Pratama, Latifah Latifah, B. Wardhani, D. Kurniasih, Syahputra Wibowo · 2025 · Open Veterinary Journal · DOI
Full title: Potential of growth factors and steroid hormones from cell cultures to improve in vitro fertilization in bovine
Authors: Sri Mulyati, F. Rantam, A. Khairullah, Imam Mustofa, A. Akintunde, R. Ahmad, Ulvi Fitri Handayani, A. Khalisa, Lili Anggraini, Bima Putra Pratama, Latifah Latifah, B. Wardhani, D. Kurniasih, Syahputra Wibowo
PaperConformational Bias in 2'-Selenium-Modified Nucleosides and the Effect on Helical Structure and Extracellular Recombinant Protein Production: Current Systems and Applications
Thompson, R. Adam · 2022 · Counseling And Psychological Services Dissertations (Georgia State University) · DOI
Full title: Conformational Bias in 2'-Selenium-Modified Nucleosides and the Effect on Helical Structure and Extracellular Recombinant Protein Production: Current Systems and Applications
Authors: Thompson, R. Adam
Year: 2022
Venue: Counseling And Psychological Services Dissertations (Georgia State University)
PaperEffect of in ovo Feeding of Graded Levels of L-glutamine on Blood Biochemistry, Colour and Texture of Selected Muscles, Carcass Quality Traits of Coloured Chicken during Heat Stress
J.K. Sharma, A. Bhattacharyya, P. Shukla, V. Pathak, M. Goswami, S. Bharti, C. Singh, Y. Singh, R. Kushwaha, A. Pandey, S. Singireddy, Tarun Singh Mathuriya, Rahul Sahu · 2026 · Journal of Advances in Biology & Biotechnology · DOI
Full title: Effect of in ovo Feeding of Graded Levels of L-glutamine on Blood Biochemistry, Colour and Texture of Selected Muscles, Carcass Quality Traits of Coloured Chicken during Heat Stress
Authors: J.K. Sharma, A. Bhattacharyya, P. Shukla, V. Pathak, M. Goswami, S. Bharti, C. Singh, Y. Singh, R. Kushwaha, A. Pandey, S. Singireddy, Tarun Singh Mathuriya, Rahul Sahu
Year: 2026
Venue: Journal of Advances in Biology & Biotechnology
PaperAchievement of high cell density and high antibody productivity by a controlled-fed perfusion bioreactor process.
Yang, J D, Angelillo, Y, Chaudhry, M, Goldenberg, C, Goldenberg, D M · 2000 · Biotechnology and bioengineering
Full title: Achievement of high cell density and high antibody productivity by a controlled-fed perfusion bioreactor process.
Authors: Yang, J D, Angelillo, Y, Chaudhry, M, Goldenberg, C, Goldenberg, D M
Year: 2000
Venue: Biotechnology and bioengineering
PaperAmélioration de la production et de la qualité des protéines thérapeutiques recombinantes produites en culture en mode cuvée-alimentée de cellules de mammifère
Karengera, Eric · 2017 · PolyPublie (École Polytechnique de Montréal)
Full title: Amélioration de la production et de la qualité des protéines thérapeutiques recombinantes produites en culture en mode cuvée-alimentée de cellules de mammifère
Authors: Karengera, Eric
Year: 2017
Venue: PolyPublie (École Polytechnique de Montréal)
PaperAn investigation into factors that cause inhibition of the growth of animal cells In Vitro
O'Toole, Angela · 1997 · Dublin City University Open Access Institutional Repository (Dublin City University)
Full title: An investigation into factors that cause inhibition of the growth of animal cells In Vitro
Authors: O'Toole, Angela
Year: 1997
Venue: Dublin City University Open Access Institutional Repository (Dublin City University)
PaperAdaptation of CHO cells in serum-free conditions for erythropoietin production: Application of EVOP technique for process optimization.
Jukić, Suzana; Bubenik, Dijana; Pavlović, Nediljko et al. · 2016 · Biotechnology and applied biochemistry · DOI
Full title: Adaptation of CHO cells in serum-free conditions for erythropoietin production: Application of EVOP technique for process optimization.
PaperCaractérisation de la mort des cellules animales cultivées en bioréacteur
Carmaux, Sandra, Annie, MARC, · 2008 · Publications Et Travaux Academiques de Lorraine (Universite de Lorraine)
Full title: Caractérisation de la mort des cellules animales cultivées en bioréacteur
Authors: Carmaux, Sandra, Annie, MARC,
Year: 2008
Venue: Publications Et Travaux Academiques de Lorraine (Universite de Lorraine)
PaperCharacterisation of the Scs system that confers copper tolerance in Salmonella enterica serovar Typhimurium
Yucel, Buke · 2019 · Kent Academic Repository (University of Kent)
Full title: Characterisation of the Scs system that confers copper tolerance in Salmonella enterica serovar Typhimurium
Authors: Yucel, Buke
Year: 2019
Venue: Kent Academic Repository (University of Kent)
PaperChemically modified cysteine in fed-batch processes and impact on CHO specific productivity
Zimmer, Aline · 2015 · Journal of Biotechnology & Biomaterials
Full title: Chemically modified cysteine in fed-batch processes and impact on CHO specific productivity
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PaperCloning, Sequencing and Expression of a Porcine Intestinal Peptide Transporter in a Mammalian Cell Line
Klang, J. E. · 2002 · VTechWorks (Virginia Tech)
Full title: Cloning, Sequencing and Expression of a Porcine Intestinal Peptide Transporter in a Mammalian Cell Line
Authors: Klang, J. E.
Year: 2002
Venue: VTechWorks (Virginia Tech)
PaperComprehensive Characterization of an Inducible Mammalian Expression System Using 13C-Metabolic Flux Analysis
Sheikholeslami, Zahra · 2013 · PolyPublie (École Polytechnique de Montréal)
Full title: Comprehensive Characterization of an Inducible Mammalian Expression System Using 13C-Metabolic Flux Analysis
Authors: Sheikholeslami, Zahra
Year: 2013
Venue: PolyPublie (École Polytechnique de Montréal)
PaperControl of development of gastrointestinal system in neonates.
Zabielski, R, Godlewski, M M, Guilloteau, P · 2008 · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
Full title: Control of development of gastrointestinal system in neonates.
Authors: Zabielski, R, Godlewski, M M, Guilloteau, P
Year: 2008
Venue: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
PaperCorrelation and Predictive Modeling of Extracellular Cell Culture Metabolites to Drug Product Titer and Cellular Viability Using Untargeted High Resolution Mass Spectrometry
Giuggio, Michael N. · 2018 · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
Full title: Correlation and Predictive Modeling of Extracellular Cell Culture Metabolites to Drug Product Titer and Cellular Viability Using Untargeted High Resolution Mass Spectrometry
Authors: Giuggio, Michael N.
Year: 2018
Venue: Digital Access to Scholarship at Harvard (DASH) (Harvard University)
PaperCorrelation between enhancing effect of sodium butyrate on specific productivity and mRNA transcription level in recombinant Chinese hamster ovary cells producing antibody.
Min Kyoung Jeon, G. Lee · 2007 · Journal of Microbiology and Biotechnology
Full title: Correlation between enhancing effect of sodium butyrate on specific productivity and mRNA transcription level in recombinant Chinese hamster ovary cells producing antibody.
Authors: Min Kyoung Jeon, G. Lee
Year: 2007
Venue: Journal of Microbiology and Biotechnology
PaperDevelopment and Application of a Chemically Defined Bioreactor Feed for CHO Cells
J. Beckmann, Benito Delgado, M. Williams, S. Mcnorton, Dennis F Cooley, J. Hartshorn · 2012
Full title: Development and Application of a Chemically Defined Bioreactor Feed for CHO Cells
Authors: J. Beckmann, Benito Delgado, M. Williams, S. Mcnorton, Dennis F Cooley, J. Hartshorn
Year: 2012
PaperDevelopment and application of quantitative liquid chromatography – mass spectrometry techniques to facilitate enhanced bioprocessing of therapeutic proteins
Farrell, Amy · 2016
Full title: Development and application of quantitative liquid chromatography – mass spectrometry techniques to facilitate enhanced bioprocessing of therapeutic proteins
Authors: Farrell, Amy
Year: 2016
PaperDevelopment of a Dynamic Model to Describe CHO cells Metabolic Network and Regulation
Ghorbaniaghdam, Atefeh · 2013 · PolyPublie (École Polytechnique de Montréal)
Full title: Development of a Dynamic Model to Describe CHO cells Metabolic Network and Regulation
Authors: Ghorbaniaghdam, Atefeh
Year: 2013
Venue: PolyPublie (École Polytechnique de Montréal)
PaperDevelopment of a Supplement for CHO Cell Culture Serum-free Media by the Fractionation of Peptide mixtures using Nanofiltration
Bissegger, Sonja · 2009 · UWSpace (University of Waterloo)
Full title: Development of a Supplement for CHO Cell Culture Serum-free Media by the Fractionation of Peptide mixtures using Nanofiltration
Authors: Bissegger, Sonja
Year: 2009
Venue: UWSpace (University of Waterloo)
PaperDevelopment of Saccharomyces cerevisiae as a recombinant antibody factory
Ruijter, Jorg C. de, Jorg, C · 2016 · Aaltodoc (Aalto University)
Full title: Development of Saccharomyces cerevisiae as a recombinant antibody factory
Authors: Ruijter, Jorg C. de, Jorg, C
Year: 2016
Venue: Aaltodoc (Aalto University)
PaperDialysis culture in animal cell growth and protein production
Amos, B. · 1995 · University of Birmingham Institutional Research Archive (University of Birmingham)
Full title: Dialysis culture in animal cell growth and protein production
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Venue: University of Birmingham Institutional Research Archive (University of Birmingham)
PaperEffect of Different Feeds and Gas Spargers on Monoclonal Antibody Yields in Stirred Tank Reactors
Ouellette, Christina Elizabeth · 2014 · Digital WPI
Full title: Effect of Different Feeds and Gas Spargers on Monoclonal Antibody Yields in Stirred Tank Reactors
Authors: Ouellette, Christina Elizabeth
Year: 2014
Venue: Digital WPI
PaperEffect of different media supplements on amino acid uptake and mitotic stimulation in BHK cells.
M. Shodell, K. Isselbacher · 1973 · Nature: New biology
Full title: Effect of different media supplements on amino acid uptake and mitotic stimulation in BHK cells.
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Year: 1973
Venue: Nature: New biology
PaperEffects of Cellular Apoptosis on Productivity of a Mammalian Cell Culture Process
Cote, Shelly A. · 2006 · Digital WPI
Full title: Effects of Cellular Apoptosis on Productivity of a Mammalian Cell Culture Process
Authors: Cote, Shelly A.
Year: 2006
Venue: Digital WPI
PaperEffects of phytase supplementation on calcium and phosphorus output, production traits and mechanical stability of the tibia in broiler chickens.
Vetési, M, Mézes, M, Baskay, G, Gelencsér, E · 1998 · Acta veterinaria Hungarica
Full title: Effects of phytase supplementation on calcium and phosphorus output, production traits and mechanical stability of the tibia in broiler chickens.
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PaperEngineering Oxidative Stress Resistance in CHO Cell Factories
Fairbrass, Danielle L · 2016 · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Full title: Engineering Oxidative Stress Resistance in CHO Cell Factories
Authors: Fairbrass, Danielle L
Year: 2016
Venue: White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
PaperEvaluation of Cellular Mechanisms Involved in Recombinant Antibody Expression in Transiently Transfected Chinese Hamster Ovary Cells
Masterjohn, Elizabeth · 2016 · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
Full title: Evaluation of Cellular Mechanisms Involved in Recombinant Antibody Expression in Transiently Transfected Chinese Hamster Ovary Cells
Authors: Masterjohn, Elizabeth
Year: 2016
Venue: Digital Access to Scholarship at Harvard (DASH) (Harvard University)
PaperFractionation of non-animal protein hydrolysates for use in Chinese Hamster Ovary cell media
Yoo, Seung Mi · 2010 · UWSpace (University of Waterloo)
Full title: Fractionation of non-animal protein hydrolysates for use in Chinese Hamster Ovary cell media
Authors: Yoo, Seung Mi
Year: 2010
Venue: UWSpace (University of Waterloo)
PaperHigh density CHO cell cultures: Improved productivity and product quality
Byrne, Karen M. · 2014
Full title: High density CHO cell cultures: Improved productivity and product quality
Authors: Byrne, Karen M.
Year: 2014
PaperHigh level recombinant antibody production in Chinese hamster ovary (CHO) cells and characterisation of the carcinoembryonic antigen (CEA) specific human full-size IgG1 H10
Full title: High level recombinant antibody production in Chinese hamster ovary (CHO) cells and characterisation of the carcinoembryonic antigen (CEA) specific human full-size IgG1 H10
Authors: Peuscher, Anne Verena, Fischer, Rainer
Year: 2011
Venue: RWTH Publications (RWTH Aachen)
PaperHigh-Throughput Platform Development for Chinese Hamster Ovary (CHO) Cell Culture Performance Enhancement Using Small Molecules.
Kalsi, Devika · 2018 · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Full title: High-Throughput Platform Development for Chinese Hamster Ovary (CHO) Cell Culture Performance Enhancement Using Small Molecules.
Authors: Kalsi, Devika
Year: 2018
Venue: White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
PaperHigh Through-Put Screening and Optimization of Serum-free Media Development for CHO Cells Using Simplex Lattice and Elements Dialogue Design Methods
Lin Xiao-l · 2014
Full title: High Through-Put Screening and Optimization of Serum-free Media Development for CHO Cells Using Simplex Lattice and Elements Dialogue Design Methods
Authors: Lin Xiao-l
Year: 2014
PaperImprovement of Semen Quality in Holstein Bulls during Heat Stress by Dietary Supplementation of Omega-3 Fatty Acids.
Gholami, Hamid, Chamani, Mohamad, Towhidi, Armin, Fazeli, Mohammad Hashem · 2011 · International journal of fertility & sterility
Full title: Improvement of Semen Quality in Holstein Bulls during Heat Stress by Dietary Supplementation of Omega-3 Fatty Acids.
Authors: Gholami, Hamid, Chamani, Mohamad, Towhidi, Armin, Fazeli, Mohammad Hashem
Year: 2011
Venue: International journal of fertility & sterility
PaperInvestigating the Restraints Upon Recombinant Protein Production in Mammalian Cells via the Manipulation of eEF2, eEF2K and mTOR
Dean, Andrew P. · 2014 · Kent Academic Repository (University of Kent)
Full title: Investigating the Restraints Upon Recombinant Protein Production in Mammalian Cells via the Manipulation of eEF2, eEF2K and mTOR
Authors: Dean, Andrew P.
Year: 2014
Venue: Kent Academic Repository (University of Kent)
PaperInvestigation into alternatives to fetal calf serum in animal cell culture
Keenan, Joanne · 1994 · Dublin City University Open Access Institutional Repository (Dublin City University)
Full title: Investigation into alternatives to fetal calf serum in animal cell culture
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Year: 1994
Venue: Dublin City University Open Access Institutional Repository (Dublin City University)
PaperInvestigation of Sf-9 Cell Metabolism Before and After Baculovirus Infection Using Biovolume: a Case for the Improvement of Adeno-Associated Viral Vector Production
Cheng, Yu-Lei · 2009 · UWSpace (University of Waterloo)
Full title: Investigation of Sf-9 Cell Metabolism Before and After Baculovirus Infection Using Biovolume: a Case for the Improvement of Adeno-Associated Viral Vector Production
Authors: Cheng, Yu-Lei
Year: 2009
Venue: UWSpace (University of Waterloo)
PaperLactagogue effects of Torbangun, a Bataknese traditional cuisine.
Damanik, Rizal, Wahlqvist, Mark L, Wattanapenpaiboon, N · 2006 · Asia Pacific journal of clinical nutrition
Full title: Lactagogue effects of Torbangun, a Bataknese traditional cuisine.
Authors: Damanik, Rizal, Wahlqvist, Mark L, Wattanapenpaiboon, N
Year: 2006
Venue: Asia Pacific journal of clinical nutrition
PaperLactation performance and milk composition studies in transgenic goats expressing recombinant proteins in the milk
Baldassarre, Hernán · 2009
Full title: Lactation performance and milk composition studies in transgenic goats expressing recombinant proteins in the milk
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PaperL-carnitine as essential methylated compound in animal metabolism. An overview.
Szilágyi, M · 1998 · Acta biologica Hungarica
Full title: L-carnitine as essential methylated compound in animal metabolism. An overview.
Authors: Szilágyi, M
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Venue: Acta biologica Hungarica
PaperLipopolysaccharide Induces The Production Of Diagnostic Monoclonal Antibody By Hybridoma Cells Against Congenital Adrenal Hyperplasia
Chua, Gek Kee, Anis, Mohamad Ariff Nur · 2017 · UMP Institutional Repository (Universiti Malaysia Pahang)
Full title: Lipopolysaccharide Induces The Production Of Diagnostic Monoclonal Antibody By Hybridoma Cells Against Congenital Adrenal Hyperplasia
Authors: Chua, Gek Kee, Anis, Mohamad Ariff Nur
Year: 2017
Venue: UMP Institutional Repository (Universiti Malaysia Pahang)
PaperMetabolic Analysis of a CHO Cell Line in Batch and Fed-batch Culture
Naderi, Saeideh · 2011 · UWSpace (University of Waterloo)
Full title: Metabolic Analysis of a CHO Cell Line in Batch and Fed-batch Culture
Authors: Naderi, Saeideh
Year: 2011
Venue: UWSpace (University of Waterloo)
PaperModélisation dynamique de cultures de cellules CHO produisant un anticorps monoclonal en mode cuvée-alimentée
Robitaille, Julien · 2015 · PolyPublie (École Polytechnique de Montréal)
Full title: Modélisation dynamique de cultures de cellules CHO produisant un anticorps monoclonal en mode cuvée-alimentée
Authors: Robitaille, Julien
Year: 2015
Venue: PolyPublie (École Polytechnique de Montréal)
PaperNeuropeptide Y at the cellular level – Studies on PreproNPY L7P Polymorphism and the Mitochondrial Form of NPY
Kaipio, Katja · 2009 · UTUPub (University of Turku)
Full title: Neuropeptide Y at the cellular level – Studies on PreproNPY L7P Polymorphism and the Mitochondrial Form of NPY
Authors: Kaipio, Katja
Year: 2009
Venue: UTUPub (University of Turku)
PaperNutrient Supplementation Strategies for Biopharmaceutical Production, Part 2 Feeding for Optimal Recombinant Protein Production
R. Fike · 2009
Full title: Nutrient Supplementation Strategies for Biopharmaceutical Production, Part 2 Feeding for Optimal Recombinant Protein Production
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Year: 2009
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Wong, Hee‐Kit, Wilke, C. R., Blanch, Harvey W. · 1983 · eScholarship (California Digital Library)
Full title: Nutritional and environmental factors in ethanol fermentation by Saccharomyces cerevisiae
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Hullár, I, Brand, A · 1993 · Acta veterinaria Hungarica
Full title: Nutritional factors affecting milk quality, with special regard to milk protein: a review.
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Jun Tang
Full title: Effects of peptone on hybridoma growth and monoclona ! antibody formation
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PaperProduction and Modeling of Recombinant Protein
Yaeck, Jason · 2007 · UWSpace (University of Waterloo)
Full title: Production and Modeling of Recombinant Protein
Authors: Yaeck, Jason
Year: 2007
Venue: UWSpace (University of Waterloo)
PaperPartial Characterization of Yeast Hydrolysates for Insights on Chemically Defined Media for Sf-9 Insect Cells
Quattrociocchi, Marco · 2017 · UWSpace (University of Waterloo)
Full title: Partial Characterization of Yeast Hydrolysates for Insights on Chemically Defined Media for Sf-9 Insect Cells
Authors: Quattrociocchi, Marco
Year: 2017
Venue: UWSpace (University of Waterloo)
PaperPeptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells.
Davami, Fatemeh, Baldi, Lucia, Rajendra, Yashas, M Wurm, Florian · 2014 · International journal of molecular and cellular medicine
Full title: Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells.
Authors: Davami, Fatemeh, Baldi, Lucia, Rajendra, Yashas, M Wurm, Florian
Year: 2014
Venue: International journal of molecular and cellular medicine
PaperProfiling the dynamic changes in the phosphoproteome of Chinese hamster ovary cells
Kaushik, Prashant · 2020 · Dublin City University Open Access Institutional Repository (Dublin City University)
Full title: Profiling the dynamic changes in the phosphoproteome of Chinese hamster ovary cells
Authors: Kaushik, Prashant
Year: 2020
Venue: Dublin City University Open Access Institutional Repository (Dublin City University)
PaperMaximizing interferon‐γ production by chinese hamster ovary cells through temperature shift optimization: <i>Experimental and modeling</i>
Fox, Stephen R.; Patel, Upasana A.; Yap, Miranda G.S. et al. · 2003 · Biotechnology and Bioengineering · DOI
Full title: Maximizing interferon‐γ production by chinese hamster ovary cells through temperature shift optimization: <i>Experimental and modeling</i>
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PaperSerum-free cell growth and differentiation studies in cultured cell lines
Meleady, Paula · 1997 · Dublin City University Open Access Institutional Repository (Dublin City University)
Full title: Serum-free cell growth and differentiation studies in cultured cell lines
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PaperSupplementation Strategies for Tuning Glycosylation of Monoclonal Antibodies and Enhancing Growth in Mammalian Cell Culture by Omics Analysis
Blondeel, Eric J. M. · 2018 · UWSpace (University of Waterloo)
Full title: Supplementation Strategies for Tuning Glycosylation of Monoclonal Antibodies and Enhancing Growth in Mammalian Cell Culture by Omics Analysis
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Year: 2018
Venue: UWSpace (University of Waterloo)
PaperThe co-modulation of apoptosis and the cell cycle
Astley, Kelly · 2010 · University of Birmingham Institutional Research Archive (University of Birmingham)
Full title: The co-modulation of apoptosis and the cell cycle
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Venue: University of Birmingham Institutional Research Archive (University of Birmingham)
PaperThe Effect of Hyper-Osmotic Conditions on the Growth, Metabolism, and Specific Antibody Productivity of a GS-NS0 Cell Line
Brady, Stefanie Ellen · 2009 · University Libraries (University of Maryland)
Full title: The Effect of Hyper-Osmotic Conditions on the Growth, Metabolism, and Specific Antibody Productivity of a GS-NS0 Cell Line
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Venue: University Libraries (University of Maryland)
PaperTherapeutic modulation of Alzheimer’s disease with biological (HUCBS) and pharmacological (LISPRO) approaches
Habib, Ahsan · 2018 · Digital Commons - University of South Florida (University of South Florida)
Full title: Therapeutic modulation of Alzheimer’s disease with biological (HUCBS) and pharmacological (LISPRO) approaches
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Year: 2018
Venue: Digital Commons - University of South Florida (University of South Florida)
PaperThe Role of Biogenic Amines and Dopamine Receptors in Envenomation by the Parasitoid Wasp Ampulex compressa
Banks, Christopher N. · 2010 · eScholarship (California Digital Library)
Full title: The Role of Biogenic Amines and Dopamine Receptors in Envenomation by the Parasitoid Wasp Ampulex compressa
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Venue: eScholarship (California Digital Library)
PaperThe Role of Different Supplements in Expression Level of Monoclonal Antibody against Human CD20.
Mahboudi, Fereidoun, Abolhassan, Mohammad Reza, Azarpanah, Armita, Aghajani-Lazarjani, Hamideh, Sadeghi-Haskoo, Mohammad Amin, Maleknia, Shaian, Vaziri, Behrouz · 2013 · Avicenna journal of medical biotechnology
Full title: The Role of Different Supplements in Expression Level of Monoclonal Antibody against Human CD20.
Authors: Mahboudi, Fereidoun, Abolhassan, Mohammad Reza, Azarpanah, Armita, Aghajani-Lazarjani, Hamideh, Sadeghi-Haskoo, Mohammad Amin, Maleknia, Shaian, Vaziri, Behrouz
Year: 2013
Venue: Avicenna journal of medical biotechnology
PaperThoroughbred blood serum inorganic phosphate concentrations in relation to feeding regime and racing performance.
Denny, J E · 1987 · Journal of the South African Veterinary Association
Full title: Thoroughbred blood serum inorganic phosphate concentrations in relation to feeding regime and racing performance.
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PaperUnderstanding the post-translational control of CD86 in regulating T cell stimulation AND What is the role of Lyp phosphatase (PTPN22) in phagocyte signaling?
Halford, Emily E. · 2012 · Jurnal Natural (Faculty of Mathematics and Natural Science, Syiah Kuala University)
Full title: Understanding the post-translational control of CD86 in regulating T cell stimulation AND What is the role of Lyp phosphatase (PTPN22) in phagocyte signaling?
Authors: Halford, Emily E.
Year: 2012
Venue: Jurnal Natural (Faculty of Mathematics and Natural Science, Syiah Kuala University)
PaperImproved production of recombinant human antithrombin III in Chinese hamster ovary cells by ATF4 overexpression
Ohya, Tomoshi; Hayashi, Tetsuji; Kiyama, Eriko et al. · 2007 · Biotechnology and Bioengineering · DOI
Full title: Improved production of recombinant human antithrombin III in Chinese hamster ovary cells by ATF4 overexpression
Paper<i>N</i>‐glycans of recombinant human interferon‐γ change during batch culture of chinese hamster ovary cells
Hooker, Andrew D.; Goldman, Merlin H.; Markham, N. et al. · 1995 · Biotechnology and Bioengineering · DOI
Full title: <i>N</i>‐glycans of recombinant human interferon‐γ change during batch culture of chinese hamster ovary cells
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PaperBridging Offline Functional Model Carrying Aging-Specific Growth Rate Information and Recombinant Protein Expression: Entropic Extension of Akaike Information Criterion.
Full title: Bridging Offline Functional Model Carrying Aging-Specific Growth Rate Information and Recombinant Protein Expression: Entropic Extension of Akaike Information Criterion.
PaperCloning of the genes for T84.66, an antibody that has a high specificity and affinity for carcinoembryonic antigen, and expression of chimeric human/mouse T84.66 genes in myeloma and Chinese hamster ovary cells.
Neumaier, Michael; Shively, L; Chen, F S et al. · 1990 · PubMed
Full title: Cloning of the genes for T84.66, an antibody that has a high specificity and affinity for carcinoembryonic antigen, and expression of chimeric human/mouse T84.66 genes in myeloma and Chinese hamster ovary cells.
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PaperAttenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production
Henry, Matthew; MacDonald, M. A.; Orellana, Camila A. et al. · 2020 · Biotechnology and Bioengineering · DOI
Full title: Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production
Authors: Henry, Matthew; MacDonald, M. A.; Orellana, Camila A.; Gray, Peter P.; Gillard, Marianne; Baker, Kym; Nielsen, Lars K.; Marcellin, Esteban; Mahler, Stephen M.; Martínez, Verónica S.
Venue: Sheng wu gong cheng xue bao = Chinese journal of biotechnology
PaperThe macroheterogeneity of recombinant human interferon-gamma produced by Chinese-hamster ovary cells is affected by the protein and lipid content of the culture medium.
Castro, P M; Ison, A P; Hayter, P M et al. · 1995 · Biotechnology and applied biochemistry
Full title: The macroheterogeneity of recombinant human interferon-gamma produced by Chinese-hamster ovary cells is affected by the protein and lipid content of the culture medium.
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Venue: Biotechnology and applied biochemistry
PaperThe effects of glucose on protein synthesis and thermosensitivity in Chinese hamster ovary cells.
Sciandra, J J; Subjeck, J R · 1983 · The Journal of biological chemistry
Full title: The effects of glucose on protein synthesis and thermosensitivity in Chinese hamster ovary cells.
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Venue: Sheng wu gong cheng xue bao = Chinese journal of biotechnology
PaperThe effect of ammonia on the <i>O</i>‐linked glycosylation of granulocyte colony‐stimulating factor produced by chinese hamster ovary cells
Andersen, Dana C.; Goochee, Charles F. · 1995 · Biotechnology and Bioengineering · DOI
Full title: The effect of ammonia on the <i>O</i>‐linked glycosylation of granulocyte colony‐stimulating factor produced by chinese hamster ovary cells
PaperConsequences of trace metal variability and supplementation on Chinese hamster ovary (CHO) cell culture performance: A review of key mechanisms and considerations.
Graham, Ryan J; Bhatia, Hemlata; Yoon, Seongkyu · 2019 · Biotechnology and bioengineering · DOI
Full title: Consequences of trace metal variability and supplementation on Chinese hamster ovary (CHO) cell culture performance: A review of key mechanisms and considerations.
Authors: Graham, Ryan J; Bhatia, Hemlata; Yoon, Seongkyu
PaperUsing MVDA with stoichiometric balances to optimize amino acid concentrations in chemically defined CHO cell culture medium for improved culture performance.
Salim, Taha; Chauhan, Gaurav; Templeton, Neil et al. · 2022 · Biotechnology and bioengineering · DOI
Full title: Using MVDA with stoichiometric balances to optimize amino acid concentrations in chemically defined CHO cell culture medium for improved culture performance.
PaperEnhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium.
Ha, Tae Kwang; Òdena, Andreu; Karottki, Karen Julie la Cour et al. · 2023 · Biotechnology and bioengineering · DOI
Full title: Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium.
Authors: Ha, Tae Kwang; Òdena, Andreu; Karottki, Karen Julie la Cour; Kim, Che Lin; Hefzi, Hooman; Lee, Gyun Min; Faustrup Kildegaard, Helene; Nielsen, Lars K; Grav, Lise Marie; Lewis, Nathan E
PaperIdentifying bottlenecks in transient and stable production of recombinant monoclonal‐antibody sequence variants in chinese hamster ovary cells
Mason, Megan; Sweeney, Bernadette; Cain, Katharine et al. · 2012 · Biotechnology Progress · DOI
Full title: Identifying bottlenecks in transient and stable production of recombinant monoclonal‐antibody sequence variants in chinese hamster ovary cells
Authors: Mason, Megan; Sweeney, Bernadette; Cain, Katharine; Stephens, Paul E.; Sharfstein, Susan T.
PaperApplication of aurintricarboxylic acid for the adherence of mouse P19 neurons and primary hippocampal neurons to noncoated surface in serum-free culture.
Lee, Tsung-Yih; Chen, Wen-Shin; Huang, Yung-An et al. · 2012 · Biotechnology progress · DOI
Full title: Application of aurintricarboxylic acid for the adherence of mouse P19 neurons and primary hippocampal neurons to noncoated surface in serum-free culture.
PaperCell culture media for recombinant protein expression in Chinese hamster ovary (CHO) cells: History, key components, and optimization strategies.
Ritacco, Frank V; Wu, Yongqi; Khetan, Anurag · 2018 · Biotechnology progress · DOI
Full title: Cell culture media for recombinant protein expression in Chinese hamster ovary (CHO) cells: History, key components, and optimization strategies.
Authors: Ritacco, Frank V; Wu, Yongqi; Khetan, Anurag
PaperPrinciples and approach to developing mammalian cell culture media for high cell density perfusion process leveraging established fed-batch media.
Lin, Henry; Leighty, Robert Woodrow; Godfrey, Scott et al. · 2017 · Biotechnology progress · DOI
Full title: Principles and approach to developing mammalian cell culture media for high cell density perfusion process leveraging established fed-batch media.
PaperRaman-based dynamic feeding strategies using real-time glucose concentration monitoring system during adalimumab producing CHO cell cultivation.
Domján, Júlia; Fricska, Annamária; Madarász, Lajos et al. · 2020 · Biotechnology progress · DOI
Full title: Raman-based dynamic feeding strategies using real-time glucose concentration monitoring system during adalimumab producing CHO cell cultivation.
PaperPreventing pyruvate kinase muscle expression in Chinese hamster ovary cells curbs lactogenic behavior by altering glycolysis, gating pyruvate generation, and increasing pyruvate flux into the TCA cycle
D. Tang, W. Sandoval, Peter S. Liu, Cynthia Lam, B. Snedecor, S. Misaghi · 2021 · Biotechnology progress (Print) · DOI
Full title: Preventing pyruvate kinase muscle expression in Chinese hamster ovary cells curbs lactogenic behavior by altering glycolysis, gating pyruvate generation, and increasing pyruvate flux into the TCA cycle
Authors: D. Tang, W. Sandoval, Peter S. Liu, Cynthia Lam, B. Snedecor, S. Misaghi
PaperCHO stable pool fed-batch process development of SARS-CoV-2 spike protein production: Impact of aeration conditions and feeding strategies.
Reyes, Sebastian-Juan; Pham, Phuong Lan; Durocher, Yves et al. · 2025 · Biotechnology progress · DOI
Full title: CHO stable pool fed-batch process development of SARS-CoV-2 spike protein production: Impact of aeration conditions and feeding strategies.
PaperUtilizing Cole-Cole parameters for in-line feedback: Cell culture process adjustments based on cell health.
N. Krishnan; Tingting Jiang; Jacob Crowe et al. · 2025 · Biotechnology progress (Print) · DOI
Full title: Utilizing Cole-Cole parameters for in-line feedback: Cell culture process adjustments based on cell health.
Authors: N. Krishnan; Tingting Jiang; Jacob Crowe; Stefano Gotta; Theresa Wittmer; Jennifer Staffenhagen; B. Alvarado; Pooja Jambunathan; Shahid Rameez
PaperOptimization of amino acid composition in CHO cell perfusion medium using definitive screening design and 1H NMR-based consumption profiling.
Xu, Shanshan; Wan, Yuxiang; Shi, Yingting et al. · 2026 · Biotechnology progress · DOI
Full title: Optimization of amino acid composition in CHO cell perfusion medium using definitive screening design and 1H NMR-based consumption profiling.
PaperUse of a Plackett-Burman statistical design to determine the effect of selected amino acids on monoclonal antibody production in CHO cells.
González-Leal, I J; Carrillo-Cocom, L M; Ramírez-Medrano, A et al. · 2011 · Biotechnology progress · DOI
Full title: Use of a Plackett-Burman statistical design to determine the effect of selected amino acids on monoclonal antibody production in CHO cells.
Authors: González-Leal, I J; Carrillo-Cocom, L M; Ramírez-Medrano, A; López-Pacheco, F; Bulnes-Abundis, D; Webb-Vargas, Y; Alvarez, M M
PaperInfluence of Primatone RL supplementation on sialylation of recombinant human interferon-gamma produced by Chinese hamster ovary cell culture using serum-free media.
Gu, X; Xie, L; Harmon, B J et al. · 1997 · Biotechnology and bioengineering · DOI
Full title: Influence of Primatone RL supplementation on sialylation of recombinant human interferon-gamma produced by Chinese hamster ovary cell culture using serum-free media.
PaperGamma-interferon production and quality in stoichiometric fed-batch cultures of Chinese hamster ovary (CHO) cells under serum-free conditions.
Xie, L; Nyberg, G; Gu, X et al. · 1997 · Biotechnology and bioengineering · DOI
Full title: Gamma-interferon production and quality in stoichiometric fed-batch cultures of Chinese hamster ovary (CHO) cells under serum-free conditions.
Authors: Xie, L; Nyberg, G; Gu, X; Li, H; Möllborn, F; Wang, D I
PaperIdentification of cellular changes associated with increased production of human growth hormone in a recombinant Chinese hamster ovary cell line
Dyk, Derek D. Van; Misztal, David R.; Wilkins, Marc R. et al. · 2003 · PROTEOMICS · DOI
Full title: Identification of cellular changes associated with increased production of human growth hormone in a recombinant Chinese hamster ovary cell line
Authors: Dyk, Derek D. Van; Misztal, David R.; Wilkins, Marc R.; Mackintosh, James A.; Poljak, Anne; Varnai, Jodie C.; Teber, Erdahl; Walsh, Bradley J.; Gray, Peter P.
PaperEnhancing therapeutic glycoprotein production in Chinese hamster ovary cells by metabolic engineering endogenous gene control with antisense DNA and gene targeting
Full title: Enhancing therapeutic glycoprotein production in Chinese hamster ovary cells by metabolic engineering endogenous gene control with antisense DNA and gene targeting
PaperEffects of <i>N</i>‐butyldeoxynojirimycin and the Lec3.2.8.1 mutant phenotype on N‐glycan processing in Chinese hamster ovary cells: Application to glycoprotein crystallization
Butters, Terry D.; Sparks, Lisa M.; Harlos, Karl et al. · 1999 · Protein Science · DOI
Full title: Effects of <i>N</i>‐butyldeoxynojirimycin and the Lec3.2.8.1 mutant phenotype on N‐glycan processing in Chinese hamster ovary cells: Application to glycoprotein crystallization
Authors: Butters, Terry D.; Sparks, Lisa M.; Harlos, Karl; Ikemizu, Shinji; Stuart, David I.; Jones, E. Yvonne; Davis, Simon J.
PaperEvaluation of pseudorabies virus glycoprotein gp50 as a vaccine for Aujeszky's disease in mice and swine: expression by vaccinia virus and Chinese hamster ovary cells
Marchioli, C C; Yancey, Robert J.; Petrovskis, Erik et al. · 1987 · Journal of Virology · DOI
Full title: Evaluation of pseudorabies virus glycoprotein gp50 as a vaccine for Aujeszky's disease in mice and swine: expression by vaccinia virus and Chinese hamster ovary cells
Authors: Marchioli, C C; Yancey, Robert J.; Petrovskis, Erik; Timmins, James; Post, Leonard
PaperCrosstalk Between Protein Restriction and Fasting and Its Impacts on Growth, Digestive Enzymes, Immunity, Antioxidant Activity, and Relative Genes of Whiteleg Shrimp (Litopenaeus vannamei).
Jahangiri, Fatemeh; Sotoudeh, Ebrahim; Ghasemi, Ahmad et al. · 2025 · Aquaculture nutrition · DOI
Full title: Crosstalk Between Protein Restriction and Fasting and Its Impacts on Growth, Digestive Enzymes, Immunity, Antioxidant Activity, and Relative Genes of Whiteleg Shrimp (Litopenaeus vannamei).
PaperCHO-S antibody titers>1 gram/liter using flow electroporation-mediated transient gene expression followed by rapid migration to high-yield stable cell lines.
Steger, Krista; Brady, James; Wang, Weili et al. · 2015 · Journal of biomolecular screening · DOI
Full title: CHO-S antibody titers>1 gram/liter using flow electroporation-mediated transient gene expression followed by rapid migration to high-yield stable cell lines.
PaperOptimization of heterologous protein production in Chinese hamster ovary cells under overexpression of spliced form of human X-box binding protein.
Gulis, Galina; Simi, Kelly Cristina Rodrigues; de Toledo, Renata Rodrigues et al. · 2014 · BMC biotechnology · DOI
Full title: Optimization of heterologous protein production in Chinese hamster ovary cells under overexpression of spliced form of human X-box binding protein.
Authors: Gulis, Galina; Simi, Kelly Cristina Rodrigues; de Toledo, Renata Rodrigues; Maranhao, Andrea Queiroz; Brigido, Marcelo Macedo
PaperA two-dimensional protein map of Chinese hamster ovary cells
Champion, Kathleen M.; Arnott, David; Henzel, William J. et al. · 1999 · Electrophoresis · DOI
Full title: A two-dimensional protein map of Chinese hamster ovary cells
Authors: Champion, Kathleen M.; Arnott, David; Henzel, William J.; Hermes, Sam M.; Weikert, Stefanie; Stults, John T.; Vanderlaan, Martin; Krummen, Lynne
PaperImproved Monoclonal Antibody Production via Controlled Feeding Strategies during Fedbatch Cultures of a Hybridoma Cell Line Utilizing Protein Free Media
W. Niloperbowo, L. Nielsen, S. Reid, P. Greenfield · 1993 · DOI
Full title: Improved Monoclonal Antibody Production via Controlled Feeding Strategies during Fedbatch Cultures of a Hybridoma Cell Line Utilizing Protein Free Media
Authors: W. Niloperbowo, L. Nielsen, S. Reid, P. Greenfield
PaperApplication of a statistical design to the optimization of culture medium for recombinant interferon-gamma production by Chinese hamster ovary cells.
Castro, P M; Hayter, P M; Ison, A P et al. · 1992 · Applied microbiology and biotechnology · DOI
Full title: Application of a statistical design to the optimization of culture medium for recombinant interferon-gamma production by Chinese hamster ovary cells.
Authors: Castro, P M; Hayter, P M; Ison, A P; Bull, A T
PaperYeast hydrolysate as a low-cost additive to serum-free medium for the production of human thrombopoietin in suspension cultures of Chinese hamster ovary cells
Sung, Yi-Juan; Lim, S. W.; Chung, Jy et al. · 2004 · Applied Microbiology and Biotechnology · DOI
Full title: Yeast hydrolysate as a low-cost additive to serum-free medium for the production of human thrombopoietin in suspension cultures of Chinese hamster ovary cells
Authors: Sung, Yi-Juan; Lim, S. W.; Chung, Jy; Lee, G. M.
PaperDown-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin
Kim, Sung Hyun; Lee, Gyun Min · 2006 · Applied Microbiology and Biotechnology · DOI
Full title: Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin
PaperPrimary metabolism in the new human cell line AGE1.HN at various substrate levels: increased metabolic efficiency and α1-antitrypsin production at reduced pyruvate load.
Niklas, Jens; Priesnitz, Christian; Rose, Thomas et al. · 2012 · Applied microbiology and biotechnology · DOI
Full title: Primary metabolism in the new human cell line AGE1.HN at various substrate levels: increased metabolic efficiency and α1-antitrypsin production at reduced pyruvate load.
PaperEnhanced cell growth, production, and mAb quality produced in Chinese hamster ovary-K1 cells by supplementing polyamine in the media.
Kang, Da Eun; An, Yeong Bin; Kim, Yeunju et al. · 2023 · Applied microbiology and biotechnology · DOI
Full title: Enhanced cell growth, production, and mAb quality produced in Chinese hamster ovary-K1 cells by supplementing polyamine in the media.
Authors: Kang, Da Eun; An, Yeong Bin; Kim, Yeunju; Ahn, Seawon; Kim, Young Jin; Lim, Jung Soo; Ryu, Soo Hyun; Choi, Hyoju; Yoo, Jiseon; You, Weon-Kyoo; Lee, Dong-Yup; Park, Junsoo; Hong, Minsun; Lee, Gyun Min; Baik, Jong Youn; Hong, Jong Kwang
PaperProteomic understanding of intracellular responses of recombinant Chinese hamster ovary cells cultivated in serum-free medium supplemented with hydrolysates.
Kim, Jee Yon; Kim, Yeon-Gu; Han, Young Kue et al. · 2011 · Applied microbiology and biotechnology · DOI
Full title: Proteomic understanding of intracellular responses of recombinant Chinese hamster ovary cells cultivated in serum-free medium supplemented with hydrolysates.
Authors: Kim, Jee Yon; Kim, Yeon-Gu; Han, Young Kue; Choi, Hyun Soo; Kim, Young Hwan; Lee, Gyun Min
PaperDifferential effects of bioreactor process variables and purification on the human recombinant lysosomal enzyme β-glucuronidase produced from Chinese hamster ovary cells
H. Parhiz, Stephanie A. Ketcham, Guozhang Zou, B. Ghosh, Erica J. Fratz-Berilla, Muhammad Ashraf, T. Ju, C. N. Madhavarao · 2019 · Applied Microbiology and Biotechnology · DOI
Full title: Differential effects of bioreactor process variables and purification on the human recombinant lysosomal enzyme β-glucuronidase produced from Chinese hamster ovary cells
Authors: H. Parhiz, Stephanie A. Ketcham, Guozhang Zou, B. Ghosh, Erica J. Fratz-Berilla, Muhammad Ashraf, T. Ju, C. N. Madhavarao
PaperOsmoprotective effect of glycine betaine on foreign protein production in hyperosmotic recombinant Chinese hamster ovary cell cultures differs among cell lines
Ryu, Joon Soo; Kim, Tae Kyung; Chung, Joo Young et al. · 2000 · Biotechnology and Bioengineering · DOI
Full title: Osmoprotective effect of glycine betaine on foreign protein production in hyperosmotic recombinant Chinese hamster ovary cell cultures differs among cell lines
Authors: Ryu, Joon Soo; Kim, Tae Kyung; Chung, Joo Young; Lee, Gyun Min
PaperOverexpression ofbcl-2 inhibits sodium butyrate-induced apoptosis in Chinese hamster ovary cells resulting in enhanced humanized antibody production
Kim, No Soo; Lee, Gyun Min · 2000 · Biotechnology and Bioengineering · DOI
Full title: Overexpression ofbcl-2 inhibits sodium butyrate-induced apoptosis in Chinese hamster ovary cells resulting in enhanced humanized antibody production
Paper13 C Flux Analysis Reveals that Rebalancing Medium Amino Acid Composition can Reduce Ammonia Production while Preserving Central Carbon Metabolism of CHO Cell Cultures.
McAtee Pereira, Allison G; Walther, Jason L; Hollenbach, Myles et al. · 2018 · Biotechnology journal · DOI
Full title: 13 C Flux Analysis Reveals that Rebalancing Medium Amino Acid Composition can Reduce Ammonia Production while Preserving Central Carbon Metabolism of CHO Cell Cultures.
Authors: McAtee Pereira, Allison G; Walther, Jason L; Hollenbach, Myles; Young, Jamey D
PaperEffect of doxycycline‐regulated calnexin and calreticulin expression on specific thrombopoietin productivity of recombinant chinese hamster ovary cells
Chung, Joo Young; Lim, Seung Wook; Hong, Yeon Joo et al. · 2004 · Biotechnology and Bioengineering · DOI
Full title: Effect of doxycycline‐regulated calnexin and calreticulin expression on specific thrombopoietin productivity of recombinant chinese hamster ovary cells
Authors: Chung, Joo Young; Lim, Seung Wook; Hong, Yeon Joo; Hwang, Sun Ok; Lee, Gyun Min
PaperNovel Data-Driven Mechanistic Modeling of Untargeted Metabolome Data Reveals Feed Component Effects in CHO Cell Bioprocess Using Column Generation-Based EFMs.
Mäkinen, Meeri E-L; Zacharouli, Markella; Särnlund, Sigrid et al. · 2025 · Biotechnology journal · DOI
Full title: Novel Data-Driven Mechanistic Modeling of Untargeted Metabolome Data Reveals Feed Component Effects in CHO Cell Bioprocess Using Column Generation-Based EFMs.
PaperReal-time amino acid and glucose monitoring system for the automatic control of nutrient feeding in CHO cell culture using Raman spectroscopy.
Domján, Júlia; Pantea, Eszter; Gyürkés, Martin et al. · 2022 · Biotechnology journal · DOI
Full title: Real-time amino acid and glucose monitoring system for the automatic control of nutrient feeding in CHO cell culture using Raman spectroscopy.
PaperInhibition of sodium butyrate‐induced apoptosis in recombinant Chinese hamster ovary cells by constitutively expressing antisense RNA of caspase‐3
Kim, No Soo; Lee, Gyun Min · 2002 · Biotechnology and Bioengineering · DOI
Full title: Inhibition of sodium butyrate‐induced apoptosis in recombinant Chinese hamster ovary cells by constitutively expressing antisense RNA of caspase‐3
PaperFed-batch production of recombinant beta-galactosidase using the universal stress promoters uspA and uspB in high cell density cultivations.
Prytz, Ingela; Sandén, Anna Maria; Nyström, Thomas et al. · 2003 · Biotechnology and bioengineering · DOI
Full title: Fed-batch production of recombinant beta-galactosidase using the universal stress promoters uspA and uspB in high cell density cultivations.
PaperEnhanced cell culture performance using inducible anti‐apoptotic genes <i>E1B‐19K</i> and <i>Aven</i> in the production of a monoclonal antibody with Chinese hamster ovary cells
Figueroa, Bruno; Ailor, Eric; Osborne, Douglas G. et al. · 2006 · Biotechnology and Bioengineering · DOI
Full title: Enhanced cell culture performance using inducible anti‐apoptotic genes <i>E1B‐19K</i> and <i>Aven</i> in the production of a monoclonal antibody with Chinese hamster ovary cells
Authors: Figueroa, Bruno; Ailor, Eric; Osborne, Douglas G.; Hardwick, J. Marie; Reff, Mitchell E.; Betenbaugh, Michael J.
PaperCombined approach of NMR and chemometrics for screening peptones used in the cell culture medium for the production of a recombinant therapeutic protein.
Luo, Ying; Chen, Guoxiang · 2007 · Biotechnology and bioengineering · DOI
Full title: Combined approach of NMR and chemometrics for screening peptones used in the cell culture medium for the production of a recombinant therapeutic protein.
PaperPost‐translational events of a model reporter protein proceed with higher fidelity and accuracy upon mild hypothermic culturing of Chinese hamster ovary cells
Masterton, Rosalyn J.; Roobol, Anne; Al‐Fageeh, Mohamed B. et al. · 2009 · Biotechnology and Bioengineering · DOI
Full title: Post‐translational events of a model reporter protein proceed with higher fidelity and accuracy upon mild hypothermic culturing of Chinese hamster ovary cells
Authors: Masterton, Rosalyn J.; Roobol, Anne; Al‐Fageeh, Mohamed B.; Carden, Martin J.; Smales, C. Mark
PaperThe effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells
Nam, Jong Hyun; Zhang, Fuming; Ermonval, Myriam et al. · 2008 · Biotechnology and Bioengineering · DOI
Full title: The effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells
Authors: Nam, Jong Hyun; Zhang, Fuming; Ermonval, Myriam; Linhardt, Robert J.; Sharfstein, Susan T.
PaperModulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose.
Gramer, Michael J; Eckblad, Jackie J; Donahue, Ruth et al. · 2011 · Biotechnology and bioengineering · DOI
Full title: Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose.
Authors: Gramer, Michael J; Eckblad, Jackie J; Donahue, Ruth; Brown, Joseph; Shultz, Carrie; Vickerman, Kent; Priem, Patrick; van den Bremer, Ewald T J; Gerritsen, Jolanda; van Berkel, Patrick H C
PaperEctopic expression of human mTOR increases viability, robustness, cell size, proliferation, and antibody production of chinese hamster ovary cells
Dreesen, Imke A.J.; Fussenegger, Martin · 2010 · Biotechnology and Bioengineering · DOI
Full title: Ectopic expression of human mTOR increases viability, robustness, cell size, proliferation, and antibody production of chinese hamster ovary cells
PaperGlucose‐limited chemostat culture of chinese hamster ovary cells producing recombinant human interferon‐γ
Hayter, Paul M.; Curling, Elisabeth M. A.; Baines, Anthony J. et al. · 1992 · Biotechnology and Bioengineering · DOI
Full title: Glucose‐limited chemostat culture of chinese hamster ovary cells producing recombinant human interferon‐γ
Authors: Hayter, Paul M.; Curling, Elisabeth M. A.; Baines, Anthony J.; Jenkins, Nigel; Salmon, Ian; Strange, Phillip G.; Tong, Jeremy M.; Bull, Alan T.
PaperAmmonia affects the glycosylation patterns of recombinant mouse placental lactogen‐I by chinese hamster ovary cells in a pH‐dependent manner
Borys, Michael; Linzer, Daniel I. H.; Papoutsakis, Eleftherios T. · 1994 · Biotechnology and Bioengineering · DOI
Full title: Ammonia affects the glycosylation patterns of recombinant mouse placental lactogen‐I by chinese hamster ovary cells in a pH‐dependent manner
Authors: Borys, Michael; Linzer, Daniel I. H.; Papoutsakis, Eleftherios T.
PaperProbing of C‐terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media
Luo, Jun; Zhang, Jian; Ren, Diya et al. · 2012 · Biotechnology and Bioengineering · DOI
Full title: Probing of C‐terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media
Authors: Luo, Jun; Zhang, Jian; Ren, Diya; Tsai, Wen‐Lin; Feng, Li; Amanullah, Ashraf; Hudson, Terry M.
PaperParallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to improve biosimilar product quality.
Brühlmann, David; Sokolov, Michael; Butté, Alessandro et al. · 2017 · Biotechnology and bioengineering · DOI
Full title: Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to improve biosimilar product quality.
PaperEstablishment of a fully automated microtiter plate-based system for suspension cell culture and its application for enhanced process optimization.
Markert, Sven; Joeris, Klaus · 2017 · Biotechnology and bioengineering · DOI
Full title: Establishment of a fully automated microtiter plate-based system for suspension cell culture and its application for enhanced process optimization.
PaperPeroxisome proliferator-induced acyl-CoA thioesterase from rat liver cytosol: molecular cloning and functional expression in Chinese hamster ovary cells
Engberg, Susanna; Aoyama, Toshifumi; Alexson, Stefan E.H. et al. · 1997 · Biochemical Journal · DOI
Full title: Peroxisome proliferator-induced acyl-CoA thioesterase from rat liver cytosol: molecular cloning and functional expression in Chinese hamster ovary cells
Authors: Engberg, Susanna; Aoyama, Toshifumi; Alexson, Stefan E.H.; Hashimoto, Takashi; Svensson, Thomas
PaperComprehensive stable-isotope tracing of glucose and amino acids identifies metabolic by-products and their sources in CHO cell culture.
Gonzalez, Jacqueline E; Naik, Harnish Mukesh; Oates, Eleanor H et al. · 2024 · Proceedings of the National Academy of Sciences of the United States of America · DOI
Full title: Comprehensive stable-isotope tracing of glucose and amino acids identifies metabolic by-products and their sources in CHO cell culture.
Authors: Gonzalez, Jacqueline E; Naik, Harnish Mukesh; Oates, Eleanor H; Dhara, Venkata Gayatri; McConnell, Brian O; Kumar, Swetha; Betenbaugh, Michael J; Antoniewicz, Maciek R
Year: 2024
Venue: Proceedings of the National Academy of Sciences of the United States of America
PaperCloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.
Yamada, Yuichiro; Post, Steven R.; Wang, K et al. · 1992 · Proceedings of the National Academy of Sciences · DOI
Full title: Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.
Authors: Yamada, Yuichiro; Post, Steven R.; Wang, K; Tager, Howard S.; Bell, George I.; Seino, Susumu
Year: 1992
Venue: Proceedings of the National Academy of Sciences
PaperCharacterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin.
Mansukhani, Alka; Dell’Era, Patrizia; Moscatelli, David et al. · 1992 · Proceedings of the National Academy of Sciences · DOI
Full title: Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin.
PaperProfactor IX Propeptide and Glutamate Substrate Binding Sites on the Vitamin K-dependent Carboxylase Identified by Site-directed Mutagenesis*
I. Sugiura, B. Furie, C. Walsh, B. Furie · 1996 · Journal of Biological Chemistry · DOI
Full title: Profactor IX Propeptide and Glutamate Substrate Binding Sites on the Vitamin K-dependent Carboxylase Identified by Site-directed Mutagenesis*
PaperThe Biosynthesis of Hepatic Cholesterol Esters and Triglycerides Is Impaired in Mice with a Disruption of the Gene for Stearoyl-CoA Desaturase 1
Miyazaki, Makoto; Kim, Young‐Cheul; Gray-Keller, Mark P. et al. · 2000 · Journal of Biological Chemistry · DOI
Full title: The Biosynthesis of Hepatic Cholesterol Esters and Triglycerides Is Impaired in Mice with a Disruption of the Gene for Stearoyl-CoA Desaturase 1
Authors: Miyazaki, Makoto; Kim, Young‐Cheul; Gray-Keller, Mark P.; Attie, Alan; Ntambi, James M.
PaperDiscovery and Investigation of Misincorporation of Serine at Asparagine Positions in Recombinant Proteins Expressed in Chinese Hamster Ovary Cells
Wen, Dingyi; Vecchi, Malgorzata M.; Gu, Sheng et al. · 2009 · Journal of Biological Chemistry · DOI
Full title: Discovery and Investigation of Misincorporation of Serine at Asparagine Positions in Recombinant Proteins Expressed in Chinese Hamster Ovary Cells
Authors: Wen, Dingyi; Vecchi, Malgorzata M.; Gu, Sheng; Su, Lihe; Dolníková, Jana; Huang, Yao‐ming; Foley, Susan F.; Garber, Ellen A.; Pederson, Nels E.; Meier, Werner
PaperEnhancement of anti-TNFα monoclonal antibody production in CHO cells through the use of UCOE and DHFR elements in vector construction and the optimization of cell culture media.
Full title: Enhancement of anti-TNFα monoclonal antibody production in CHO cells through the use of UCOE and DHFR elements in vector construction and the optimization of cell culture media.
PaperNutrient supplementation strategy improves cell concentration and longevity, monoclonal antibody production and lactate metabolism of Chinese hamster ovary cells.
Pérez-Rodriguez, Saumel; Ramírez-Lira, María de Jesús; Trujillo-Roldán, Mauricio A et al. · 2020 · Bioengineered · DOI
Full title: Nutrient supplementation strategy improves cell concentration and longevity, monoclonal antibody production and lactate metabolism of Chinese hamster ovary cells.
Authors: Pérez-Rodriguez, Saumel; Ramírez-Lira, María de Jesús; Trujillo-Roldán, Mauricio A; Valdez-Cruz, Norma A
PaperComposition and colour indices of sheep’s bulk-tank milk are influenced by production practices
L. Jiménez Sobrino, J. P. Poveda Colado, A. I. Garzón Sigler, A. M. Martínez Marín, N. Núñez Sánchez, Jesús Romero Asensio, María Dolores Pérez-Guzmán Palomares, R. Arias Sánchez · 2017 · DOI
Full title: Composition and colour indices of sheep’s bulk-tank milk are influenced by production practices
Authors: L. Jiménez Sobrino, J. P. Poveda Colado, A. I. Garzón Sigler, A. M. Martínez Marín, N. Núñez Sánchez, Jesús Romero Asensio, María Dolores Pérez-Guzmán Palomares, R. Arias Sánchez
PaperSystematic development of temperature shift strategies for Chinese hamster ovary cells based on short duration cultures and kinetic modeling
Xu, Jianlin; Tang, Peifeng; Yongky, Andrew et al. · 2018 · mAbs · DOI
Full title: Systematic development of temperature shift strategies for Chinese hamster ovary cells based on short duration cultures and kinetic modeling
PaperManNAc attenuates Man5 glycoform abundance through GNE-mediated metabolic channeling of UDP-GlcNAc to N-glycosylation modifications via CMP-Neu5Ac biosynthesis
Full title: ManNAc attenuates Man5 glycoform abundance through GNE-mediated metabolic channeling of UDP-GlcNAc to N-glycosylation modifications via CMP-Neu5Ac biosynthesis
PaperImproving titer while maintaining quality of final formulated drug substance via optimization of CHO cell culture conditions in low-iron chemically defined media.
Xu, Jianlin; Rehmann, Matthew S; Xu, Xuankuo et al. · 2018 · mAbs · DOI
Full title: Improving titer while maintaining quality of final formulated drug substance via optimization of CHO cell culture conditions in low-iron chemically defined media.
PaperIncorporation of 15N from ammonium into the N-linked oligosaccharides of an immunoadhesin glycoprotein expressed in Chinese hamster ovary cells
Gawlitzek, Martin; Papac, Damon I.; Sliwkowski, Mary B. et al. · 1999 · Glycobiology · DOI
Full title: Incorporation of 15N from ammonium into the N-linked oligosaccharides of an immunoadhesin glycoprotein expressed in Chinese hamster ovary cells
Authors: Gawlitzek, Martin; Papac, Damon I.; Sliwkowski, Mary B.; Ryll, Thomas
PaperMetabolic engineering of Chinese hamster ovary cells: Towards a bioengineered heparin
Baik, Jong Youn; Gasimli, Leyla; Yang, Bo et al. · 2012 · Metabolic Engineering · DOI
Full title: Metabolic engineering of Chinese hamster ovary cells: Towards a bioengineered heparin
Authors: Baik, Jong Youn; Gasimli, Leyla; Yang, Bo; Datta, P.K.; Zhang, Fuming; Glass, Charles A.; Esko, Jeffrey D.; Linhardt, Robert J.; Sharfstein, Susan T.
PaperInferring secretory and metabolic pathway activity from omic data with secCellFie.
Helen Masson, M. Samoudi, C. M. Robinson, Chih-Chung Kuo, Linus Weiss, Km Shams Ud Doha, Alex Campos, Vijay Tejwani, Hussain Dahodwala, Patrice Ménard, B. Voldborg, Bradley Robasky, S. Sharfstein, Nathan E. Lewis · 2023 · Metabolic Engineering · DOI
Full title: Inferring secretory and metabolic pathway activity from omic data with secCellFie.
Authors: Helen Masson, M. Samoudi, C. M. Robinson, Chih-Chung Kuo, Linus Weiss, Km Shams Ud Doha, Alex Campos, Vijay Tejwani, Hussain Dahodwala, Patrice Ménard, B. Voldborg, Bradley Robasky, S. Sharfstein, Nathan E. Lewis
PaperReconstruction of reverse transsulfuration pathway enables cysteine biosynthesis and enhances resilience to oxidative stress in Chinese Hamster Ovary cells.
Chen, Yiqun; Betenbaugh, Michael J · 2023 · Metabolic engineering · DOI
Full title: Reconstruction of reverse transsulfuration pathway enables cysteine biosynthesis and enhances resilience to oxidative stress in Chinese Hamster Ovary cells.
PaperDifferential expression of an E-selectin ligand (SLex) by two Chinese hamster ovary cell lines transfected with the same alpha (1,3)-fucosyltransferase gene (ELFT).
S. Goelz; R. Kumar; B. Potvin et al. · 1994 · Journal of Biological Chemistry · DOI
Full title: Differential expression of an E-selectin ligand (SLex) by two Chinese hamster ovary cell lines transfected with the same alpha (1,3)-fucosyltransferase gene (ELFT).
Authors: S. Goelz; R. Kumar; B. Potvin; S. Sundaram; M. Brickelmaier; P. Stanley
PaperRegulation of phosphatidylcholine metabolism in mammalian cells. Isolation and characterization of a Chinese hamster ovary cell pleiotropic mutant defective in both choline kinase and choline-exchange reaction activities.
Nishijima, Masahiro; Kuge, Osamu; Maeda, Masatomo et al. · 1984 · Journal of Biological Chemistry · DOI
Full title: Regulation of phosphatidylcholine metabolism in mammalian cells. Isolation and characterization of a Chinese hamster ovary cell pleiotropic mutant defective in both choline kinase and choline-exchange reaction activities.
PaperSphingolipids are essential for the growth of Chinese hamster ovary cells. Restoration of the growth of a mutant defective in sphingoid base biosynthesis by exogenous sphingolipids.
Hanada, Kentaro; Nishijima, Masahiro; KISO, M. et al. · 1992 · Journal of Biological Chemistry · DOI
Full title: Sphingolipids are essential for the growth of Chinese hamster ovary cells. Restoration of the growth of a mutant defective in sphingoid base biosynthesis by exogenous sphingolipids.
Authors: Hanada, Kentaro; Nishijima, Masahiro; KISO, M.; Hasegawa, Ayaka; Fujita, Shushi; Ogawa, Tomohisa; Akamatsu, Y
PaperRegulation of folylpoly-gamma-glutamate synthesis in mammalian cells. In vivo and in vitro synthesis of pteroylpoly-gamma-glutamates by Chinese hamster ovary cells.
Foo, Siang K.; Shane, Barry · 1982 · Journal of Biological Chemistry · DOI
Full title: Regulation of folylpoly-gamma-glutamate synthesis in mammalian cells. In vivo and in vitro synthesis of pteroylpoly-gamma-glutamates by Chinese hamster ovary cells.
PaperRegulation of phosphatidylcholine biosynthesis in mammalian cells. II. Effects of phospholipase C treatment on the activity and subcellular distribution of CTP:phosphocholine cytidylyltransferase in Chinese hamster ovary and LM cell lines.
Sleight, Richard G.; Kent, C · 1983 · Journal of Biological Chemistry · DOI
Full title: Regulation of phosphatidylcholine biosynthesis in mammalian cells. II. Effects of phospholipase C treatment on the activity and subcellular distribution of CTP:phosphocholine cytidylyltransferase in Chinese hamster ovary and LM cell lines.
PaperRegulation of phosphatidylcholine biosynthesis in mammalian cells. I. Effects of phospholipase C treatment on phosphatidylcholine metabolism in Chinese hamster ovary cells and LM mouse fibroblasts.
Sleight, Richard G.; Kent, C · 1983 · Journal of Biological Chemistry · DOI
Full title: Regulation of phosphatidylcholine biosynthesis in mammalian cells. I. Effects of phospholipase C treatment on phosphatidylcholine metabolism in Chinese hamster ovary cells and LM mouse fibroblasts.
PaperExpression of the aminoacyl-tRNA synthetase complex in cultured Chinese hamster ovary cells. Specific depression of the methionyl-tRNA synthetase component upon methionine restriction.
Lazard, Myriam; Mirande, Marc; Waller, Jean‐Pierre · 1987 · Journal of Biological Chemistry · DOI
Full title: Expression of the aminoacyl-tRNA synthetase complex in cultured Chinese hamster ovary cells. Specific depression of the methionyl-tRNA synthetase component upon methionine restriction.
PaperControl of ornithine decarboxylase in Chinese hamster ovary cells by polyamines. Translational inhibition of synthesis and acceleration of degradation of the enzyme by putrescine, spermidine, and spermine.
Hölttä, Erkki; Pohjanpelto, Pirkko · 1986 · Journal of Biological Chemistry · DOI
Full title: Control of ornithine decarboxylase in Chinese hamster ovary cells by polyamines. Translational inhibition of synthesis and acceleration of degradation of the enzyme by putrescine, spermidine, and spermine.
PaperFunctional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: 1. Activation of postsynaptic D3 receptors mediates hypothermia, whereas blockade of D2 receptors elicits prolactin secretion and catalepsy.
Mark J. Millan, J. Peglion, J. Vian, J. Rivet, M. Brocco, A. Gobert, A. Newman-Tancredi, Catherine Dacquet, K. Bervoets, S. Girardon · 1995 · Journal of Pharmacology and Experimental Therapeutics · DOI
Full title: Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: 1. Activation of postsynaptic D3 receptors mediates hypothermia, whereas blockade of D2 receptors elicits prolactin secretion and catalepsy.
Authors: Mark J. Millan, J. Peglion, J. Vian, J. Rivet, M. Brocco, A. Gobert, A. Newman-Tancredi, Catherine Dacquet, K. Bervoets, S. Girardon
Year: 1995
Venue: Journal of Pharmacology and Experimental Therapeutics
PaperDevelopment of a serum-free medium for the production of erythropoietin by suspension culture of recombinant Chinese hamster ovary cells using a statistical design.
Lee, G M; Kim, E J; Kim, N S et al. · 1999 · Journal of biotechnology · DOI
Full title: Development of a serum-free medium for the production of erythropoietin by suspension culture of recombinant Chinese hamster ovary cells using a statistical design.
Authors: Lee, G M; Kim, E J; Kim, N S; Yoon, S K; Ahn, Y H; Song, J Y
PaperAcidic Derivatization of Thiols Using Diethyl 2-Methylenemalonate: Thiol-Michael Addition Click Reaction for Simultaneous Analysis of Cysteine and Cystine in Culture Media Using LC-MS/MS.
Harada, Masashi; Kato, Yumiko; Tsuji, Chihiro et al. · 2024 · Analytical chemistry · DOI
Full title: Acidic Derivatization of Thiols Using Diethyl 2-Methylenemalonate: Thiol-Michael Addition Click Reaction for Simultaneous Analysis of Cysteine and Cystine in Culture Media Using LC-MS/MS.
PaperInvestigation of protein patterns in mammalian cells and culture supernatants by matrix-assisted laser desorption/ionization mass spectrometry.
van Adrichem, J H; Börnsen, K O; Conzelmann, H et al. · 1998 · Analytical chemistry · DOI
Full title: Investigation of protein patterns in mammalian cells and culture supernatants by matrix-assisted laser desorption/ionization mass spectrometry.
Authors: van Adrichem, J H; Börnsen, K O; Conzelmann, H; Gass, M A; Eppenberger, H; Kresbach, G M; Ehrat, M; Leist, C H
PaperEffect of Low Culture Temperature on Specific Productivity and Transcription Level of Anti-4-1BB Antibody in Recombinant Chinese Hamster Ovary Cells
Yoon, Sung Kwan; Kim, Sung Hyun; Lee, Gyun Min · 2003 · Biotechnology Progress · DOI
Full title: Effect of Low Culture Temperature on Specific Productivity and Transcription Level of Anti-4-1BB Antibody in Recombinant Chinese Hamster Ovary Cells
Authors: Yoon, Sung Kwan; Kim, Sung Hyun; Lee, Gyun Min
PaperLimitations to the Development of Humanized Antibody Producing Chinese Hamster Ovary Cells Using Glutamine Synthetase-Mediated Gene Amplification
Jun, Sung Chan; Kim, Minsoo; Hong, H.J. et al. · 2006 · Biotechnology Progress · DOI
Full title: Limitations to the Development of Humanized Antibody Producing Chinese Hamster Ovary Cells Using Glutamine Synthetase-Mediated Gene Amplification
Authors: Jun, Sung Chan; Kim, Minsoo; Hong, H.J.; Lee, G.M.
PaperControl of culture environment for improved polyethylenimine-mediated transient production of recombinant monoclonal antibodies by CHO cells.
Galbraith, Douglas J; Tait, Andrew S; Racher, Andrew J et al. · 2006 · Biotechnology progress · DOI
Full title: Control of culture environment for improved polyethylenimine-mediated transient production of recombinant monoclonal antibodies by CHO cells.
Authors: Galbraith, Douglas J; Tait, Andrew S; Racher, Andrew J; Birch, John R; James, David C
PaperHigh Level Expression of Tissue Inhibitor of Metalloproteinases in Chinese Hamster Ovary Cells Using Glutamine Synthetase Gene Amplification
Cockett, Mark I.; Bebbington, C. R.; Yarranton, Geoffrey · 1990 · Nature Biotechnology · DOI
Full title: High Level Expression of Tissue Inhibitor of Metalloproteinases in Chinese Hamster Ovary Cells Using Glutamine Synthetase Gene Amplification
Authors: Cockett, Mark I.; Bebbington, C. R.; Yarranton, Geoffrey
PaperProduction of analytical quantities of recombinant proteins in Chinese hamster ovary cells using sodium butyrate to elevate gene expression
Palermo, Daniel P.; DeGraaf, Michael E.; Marotti, K.R. et al. · 1991 · Journal of Biotechnology · DOI
Full title: Production of analytical quantities of recombinant proteins in Chinese hamster ovary cells using sodium butyrate to elevate gene expression
Authors: Palermo, Daniel P.; DeGraaf, Michael E.; Marotti, K.R.; Rehberg, E.F.; Post, Leonard
PaperNovel chemometric strategy based on the application of artificial neural networks to crossed mixture design for the improvement of recombinant protein production in continuous culture.
Didier, Caroline; Forno, Guillermina; Etcheverrigaray, Marina et al. · 2009 · Analytica chimica acta · DOI
Full title: Novel chemometric strategy based on the application of artificial neural networks to crossed mixture design for the improvement of recombinant protein production in continuous culture.
PaperUsability of size-excluded fractions of soy protein hydrolysates for growth and viability of Chinese hamster ovary cells in protein-free suspension culture
Chun, Bok-Hwan; Kim, Jong-Hwang; Lee, Ho-Joung et al. · 2006 · Bioresource Technology · DOI
Full title: Usability of size-excluded fractions of soy protein hydrolysates for growth and viability of Chinese hamster ovary cells in protein-free suspension culture
Authors: Chun, Bok-Hwan; Kim, Jong-Hwang; Lee, Ho-Joung; Chung, Namhyun
PaperRecent advances in culture medium design for enhanced production of monoclonal antibodies in CHO cells: A comparative study of machine learning and systems biology approaches.
Kavoni, Hossein; Savizi, Iman Shahidi Pour; Lewis, Nathan E et al. · 2025 · Biotechnology advances · DOI
Full title: Recent advances in culture medium design for enhanced production of monoclonal antibodies in CHO cells: A comparative study of machine learning and systems biology approaches.
Authors: Kavoni, Hossein; Savizi, Iman Shahidi Pour; Lewis, Nathan E; Shojaosadati, Seyed Abbas
PaperImproving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
Hansen, Henning Gram; Pristovšek, Nuša; Kildegaard, Helene Faustrup et al. · 2016 · Biotechnology Advances · DOI
Full title: Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
Authors: Hansen, Henning Gram; Pristovšek, Nuša; Kildegaard, Helene Faustrup; Lee, Gyun Min
PaperEffect of co-overexpression of the cargo receptor ERGIC-53/MCFD2 on antibody production and intracellular IgG secretion in recombinant Chinese hamster ovary cells.
Kirimoto, Yutaka; Yamano-Adachi, Noriko; Koga, Yuichi et al. · 2023 · Journal of bioscience and bioengineering · DOI
Full title: Effect of co-overexpression of the cargo receptor ERGIC-53/MCFD2 on antibody production and intracellular IgG secretion in recombinant Chinese hamster ovary cells.
PaperStrategies for fed-batch cultivation of t-PA producing CHO cells: substitution of glucose and glutamine and rational design of culture medium.
Altamirano, C; Paredes, C; Illanes, A et al. · 2004 · Journal of biotechnology · DOI
Full title: Strategies for fed-batch cultivation of t-PA producing CHO cells: substitution of glucose and glutamine and rational design of culture medium.
PaperEffect of sodium butyrate on the production, heterogeneity and biological activity of human thrombopoietin by recombinant Chinese hamster ovary cells
Sung, Yun Hee; Song, Yeon Jung; Lim, Seung Wook et al. · 2004 · Journal of Biotechnology · DOI
Full title: Effect of sodium butyrate on the production, heterogeneity and biological activity of human thrombopoietin by recombinant Chinese hamster ovary cells
PaperAn XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes.
Becker, Eric; Florin, Lore; Pfizenmaier, Klaus et al. · 2008 · Journal of biotechnology · DOI
Full title: An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes.
PaperEnhancing precursors availability in Pichia pastoris for the overproduction of S-adenosyl-L-methionine employing molecular strategies with process tuning.
Ravi Kant, Harit; Balamurali, M; Meenakshisundaram, Sankaranarayanan · 2014 · Journal of biotechnology · DOI
Full title: Enhancing precursors availability in Pichia pastoris for the overproduction of S-adenosyl-L-methionine employing molecular strategies with process tuning.
Authors: Ravi Kant, Harit; Balamurali, M; Meenakshisundaram, Sankaranarayanan
PapermiRNA profiling of high, low and non-producing CHO cells during biphasic fed-batch cultivation reveals process relevant targets for host cell engineering.
Stiefel, Fabian; Fischer, Simon; Sczyrba, Alexander et al. · 2016 · Journal of biotechnology · DOI
Full title: miRNA profiling of high, low and non-producing CHO cells during biphasic fed-batch cultivation reveals process relevant targets for host cell engineering.
PaperEnhancing thermo-induced recombinant protein production in Escherichia coli by temperature oscillations and post-induction nutrient feeding strategies.
Caspeta, Luis; Lara, Alvaro R; Pérez, Néstor O et al. · 2013 · Journal of biotechnology · DOI
Full title: Enhancing thermo-induced recombinant protein production in Escherichia coli by temperature oscillations and post-induction nutrient feeding strategies.
PaperTranscriptomic changes in CHO cells after adaptation to suspension growth in protein-free medium analysed by a species-specific microarray.
Shridhar, Smriti; Klanert, Gerald; Auer, Norbert et al. · 2017 · Journal of biotechnology · DOI
Full title: Transcriptomic changes in CHO cells after adaptation to suspension growth in protein-free medium analysed by a species-specific microarray.
Authors: Shridhar, Smriti; Klanert, Gerald; Auer, Norbert; Hernandez-Lopez, Inmaculada; Kańduła, Maciej M; Hackl, Matthias; Grillari, Johannes; Stralis-Pavese, Nancy; Kreil, David P; Borth, Nicole
PaperTransfection of miR-31* boosts oxidative phosphorylation metabolism in the mitochondria and enhances recombinant protein production in Chinese hamster ovary cells.
J. E. Martínez-López, Orla Coleman, P. Meleady, M. Clynes · 2021 · Journal of Biotechnology · DOI
Full title: Transfection of miR-31* boosts oxidative phosphorylation metabolism in the mitochondria and enhances recombinant protein production in Chinese hamster ovary cells.
Authors: J. E. Martínez-López, Orla Coleman, P. Meleady, M. Clynes
PaperMonitoring utilizations of amino acids and vitamins in culture media and Chinese hamster ovary cells by liquid chromatography tandem mass spectrometry.
Qiu, Jinshu; Chan, Pik Kay; Bondarenko, Pavel V · 2016 · Journal of pharmaceutical and biomedical analysis · DOI
Full title: Monitoring utilizations of amino acids and vitamins in culture media and Chinese hamster ovary cells by liquid chromatography tandem mass spectrometry.
Authors: Qiu, Jinshu; Chan, Pik Kay; Bondarenko, Pavel V
Year: 2016
Venue: Journal of pharmaceutical and biomedical analysis
PaperEffect of protein supplementation in potassium simplex optimization medium on preimplantation development of bovine non-transgenic and transgenic cloned embryos.
Bhuiyan, M M U; Cho, Jong-ki; Jang, Goo et al. · 2004 · Theriogenology · DOI
Full title: Effect of protein supplementation in potassium simplex optimization medium on preimplantation development of bovine non-transgenic and transgenic cloned embryos.
Authors: Bhuiyan, M M U; Cho, Jong-ki; Jang, Goo; Park, Eul-soon; Kang, Sung-keun; Lee, Byeong-chun; Hwang, Woo-suk
PaperDeciphering Metabolic Pathways in High-Seeding-Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective
Full title: Deciphering Metabolic Pathways in High-Seeding-Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective
PaperComputer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.
Traustason, Bergthor; Cheeks, Matthew; Dikicioglu, Duygu · 2019 · International journal of molecular sciences · DOI
Full title: Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.
PaperInhibition of tumor growth in a mouse xenograft model by the humanized anti-HGF monoclonal antibody YYB-101 produced in a large-scale CHO cell culture.
Song, Seong-Won; Lee, Song-Jae; Kim, Chang-Young et al. · 2013 · Journal of microbiology and biotechnology · DOI
Full title: Inhibition of tumor growth in a mouse xenograft model by the humanized anti-HGF monoclonal antibody YYB-101 produced in a large-scale CHO cell culture.
PaperEffects of Peptone Supplementation in Different Culture Media on Growth, Metabolic Pathway and Productivity of CHO DG44 Cells; a New Insight into Amino Acid Profiles.
Davami, Fatemeh; Eghbalpour, Farnaz; Nematollahi, Leila et al. · 2015 · Iranian biomedical journal · DOI
Full title: Effects of Peptone Supplementation in Different Culture Media on Growth, Metabolic Pathway and Productivity of CHO DG44 Cells; a New Insight into Amino Acid Profiles.
PaperPre-stage perfusion and ultra-high seeding cell density in CHO fed-batch culture: a case study for process intensification guided by systems biotechnology.
Stepper, Lisa; Filser, Florian Alois; Fischer, Simon et al. · 2020 · Bioprocess and biosystems engineering · DOI
Full title: Pre-stage perfusion and ultra-high seeding cell density in CHO fed-batch culture: a case study for process intensification guided by systems biotechnology.
PaperCompartment-specific metabolome labeling enables the identification of subcellular fluxes that may serve as promising metabolic engineering targets in CHO cells.
Wijaya, Andy Wiranata; Ulmer, Andreas; Hundsdorfer, Lara et al. · 2021 · Bioprocess and biosystems engineering · DOI
Full title: Compartment-specific metabolome labeling enables the identification of subcellular fluxes that may serve as promising metabolic engineering targets in CHO cells.
PaperBioprocess biomarker identification and diagnosis for industrial mAb production based on metabolic profiling and multivariate data analysis.
Shi, Yingting; Wan, Yuxiang; Yang, Jiayu et al. · 2025 · Bioprocess and biosystems engineering · DOI
Full title: Bioprocess biomarker identification and diagnosis for industrial mAb production based on metabolic profiling and multivariate data analysis.
PaperParallelized microscale fed-batch cultivation in online-monitored microtiter plates: implications of media composition and feed strategies for process design and performance.
Morschett, Holger; Jansen, Roman; Neuendorf, Christian et al. · 2020 · Journal of industrial microbiology & biotechnology · DOI
Full title: Parallelized microscale fed-batch cultivation in online-monitored microtiter plates: implications of media composition and feed strategies for process design and performance.
PaperA novel method based on nonparametric regression with a Gaussian kernel algorithm identifies the critical components in CHO media and feed optimization.
Zou, Mao; Zhou, Zi-Wei; Fan, Li et al. · 2020 · Journal of industrial microbiology & biotechnology · DOI
Full title: A novel method based on nonparametric regression with a Gaussian kernel algorithm identifies the critical components in CHO media and feed optimization.
PaperNovel cholesterol feeding strategy enables a high-density cultivation of cholesterol-dependent NS0 cells in linear low-density polyethylene-based disposable bioreactors
Yiwen Tao, H. Yusuf‐Makagiansar, Jennifer Shih, T. Ryll, M. Sinacore · 2012 · Biotechnology Letters · DOI
Full title: Novel cholesterol feeding strategy enables a high-density cultivation of cholesterol-dependent NS0 cells in linear low-density polyethylene-based disposable bioreactors
Authors: Yiwen Tao, H. Yusuf‐Makagiansar, Jennifer Shih, T. Ryll, M. Sinacore
PaperDevelopment of a chemically defined platform fed-batch culture media for monoclonal antibody-producing CHO cell lines with optimized choline content.
Full title: Development of a chemically defined platform fed-batch culture media for monoclonal antibody-producing CHO cell lines with optimized choline content.
PaperA case study: Correlation of the nutrient composition in Chinese Hamster Ovary cultures with cell growth, antibody titre and quality attributes using multivariate analyses for guiding medium and feed optimization in early upstream process development.
Saldanha, Marianne; Shelar, Ashutosh; Patil, Vaibhav et al. · 2023 · Cytotechnology · DOI
Full title: A case study: Correlation of the nutrient composition in Chinese Hamster Ovary cultures with cell growth, antibody titre and quality attributes using multivariate analyses for guiding medium and feed optimization in early upstream process development.
PaperComparative study of commercial media to improve GMP manufacturing of recombinant human interferon β-1a by CHO cells in perfusion bioreactor.
Sedighikamal, Hossein; Karimi Mostofi, Reza; Sattarzadeh, Alireza et al. · 2022 · Cytotechnology · DOI
Full title: Comparative study of commercial media to improve GMP manufacturing of recombinant human interferon β-1a by CHO cells in perfusion bioreactor.
PaperDevelopment of a serum-free medium for dihydrofolate reductase-deficient Chinese hamster ovary cells (DG44) using a statistical design: beneficial effect of weaning of cells.
Kim, E J; Kim, N S; Lee, G M · 1999 · In vitro cellular & developmental biology. Animal · DOI
Full title: Development of a serum-free medium for dihydrofolate reductase-deficient Chinese hamster ovary cells (DG44) using a statistical design: beneficial effect of weaning of cells.
Authors: Kim, E J; Kim, N S; Lee, G M
Year: 1999
Venue: In vitro cellular & developmental biology. Animal
PaperPurification and characterization of recombinant human thyrotropin (TSH) isoforms produced by Chinese hamster ovary cells: the role of sialylation and sulfation in TSH bioactivity.
Szkudlinski, Mariusz W.; Thotakura, N R; Bucci, Ines et al. · 1993 · Endocrinology · DOI
Full title: Purification and characterization of recombinant human thyrotropin (TSH) isoforms produced by Chinese hamster ovary cells: the role of sialylation and sulfation in TSH bioactivity.
Authors: Szkudlinski, Mariusz W.; Thotakura, N R; Bucci, Ines; Joshi, Lata; Tsai, Amos M.; East-Palmer, Joyce; Shiloach, Joseph; Weintraub, B D
PaperPurification and characterization of recombinant human thyrotropin (TSH) isoforms produced by Chinese hamster ovary cells: the role of sialylation and sulfation in TSH bioactivity.
Szkudlinski, Mariusz W.; Thotakura, N R; Bucci, Ines et al. · 1993 · Endocrinology · DOI
Full title: Purification and characterization of recombinant human thyrotropin (TSH) isoforms produced by Chinese hamster ovary cells: the role of sialylation and sulfation in TSH bioactivity.
Authors: Szkudlinski, Mariusz W.; Thotakura, N R; Bucci, Ines; Joshi, Lata; Tsai, Amos M.; East-Palmer, Joyce; Shiloach, Joseph; Weintraub, B D
PaperThe murine macrophage apoB-48 receptor gene (Apob-48r): homology to the human receptor.
Matthew L. Brown, K. Yui, Jonathan D. Smith, R. Leboeuf, W. Weng, P. Umeda, Ran Li, R. Song, S. Gianturco, W. Bradley · 2002 · Journal of Lipid Research · DOI
Full title: The murine macrophage apoB-48 receptor gene (Apob-48r): homology to the human receptor.
Authors: Matthew L. Brown, K. Yui, Jonathan D. Smith, R. Leboeuf, W. Weng, P. Umeda, Ran Li, R. Song, S. Gianturco, W. Bradley
Paper4-(2,5-Dimethyl-1H-pyrrol-1-yl)-N-(2,5-dioxopyrrolidin-1-yl) benzamide improves monoclonal antibody production in a Chinese hamster ovary cell culture.
Aki, Yuichi; Katsumata, Yuta; Kakihara, Hirofumi et al. · 2021 · PloS one · DOI
Full title: 4-(2,5-Dimethyl-1H-pyrrol-1-yl)-N-(2,5-dioxopyrrolidin-1-yl) benzamide improves monoclonal antibody production in a Chinese hamster ovary cell culture.
PaperProteomics Profiling of Chimeric-Truncated Tissue Plasminogen activator Producing- Chinese Hamster Ovary Cells Cultivated in a Chemically Defined Medium Supplemented with Protein Hydrolysates.
Azarian, Bahareh; Sajedin, Seyedeh Matin; Azimi, Amin et al. · 2017 · Iranian biomedical journal · DOI
Full title: Proteomics Profiling of Chimeric-Truncated Tissue Plasminogen activator Producing- Chinese Hamster Ovary Cells Cultivated in a Chemically Defined Medium Supplemented with Protein Hydrolysates.
PaperEffects of different durations of fasting/re-feeding bouts on growth, biochemical and histological changes in the digestive tract of Gansu golden trout (Oncorhynchus mykiss)
X. Liu, I. Hegab, J. Su, X. Du, X. Fan, Q. Zhang, Y. Gao, H. Wang · 2018 · Czech Journal of Animal Science · DOI
Full title: Effects of different durations of fasting/re-feeding bouts on growth, biochemical and histological changes in the digestive tract of Gansu golden trout (Oncorhynchus mykiss)
Authors: X. Liu, I. Hegab, J. Su, X. Du, X. Fan, Q. Zhang, Y. Gao, H. Wang
PaperHeterotrophically Ultrahigh-Cell-Density Cultivation of a High Protein-Yielding Unicellular Alga Chlorella With a Novel Nitrogen-Supply Strategy.
Xu, Quan; Hou, Guoli; Chen, Jianping et al. · 2021 · Frontiers in bioengineering and biotechnology · DOI
Full title: Heterotrophically Ultrahigh-Cell-Density Cultivation of a High Protein-Yielding Unicellular Alga Chlorella With a Novel Nitrogen-Supply Strategy.
PaperTranscriptomic Analysis of Pichia pastoris (Komagataella phaffii) GS115 During Heterologous Protein Production Using a High-Cell-Density Fed-Batch Cultivation Strategy.
Zhang, Chengbo; Ma, Yu; Miao, Huabiao et al. · 2020 · Frontiers in microbiology · DOI
Full title: Transcriptomic Analysis of Pichia pastoris (Komagataella phaffii) GS115 During Heterologous Protein Production Using a High-Cell-Density Fed-Batch Cultivation Strategy.
PaperDifferent feeding strategies can affect growth performance and rumen functions in Gangba sheep as revealed by integrated transcriptome and microbiome analyses.
Jize, Zhang; Zhuoga, Deqing; Xiaoqing, Zhang et al. · 2022 · Frontiers in microbiology · DOI
Full title: Different feeding strategies can affect growth performance and rumen functions in Gangba sheep as revealed by integrated transcriptome and microbiome analyses.
ThesisManufacture of Recombinant Therapeutic Proteins Using Chinese Hamster Ovary Cells in Large-Scale Bioreactors History, Methods, and Perspectives
Wurm, Florian Maria; de Jesus, Maria · 2025 · Theses · DOI
Full title: Manufacture of Recombinant Therapeutic Proteins Using Chinese Hamster Ovary Cells in Large-Scale Bioreactors History, Methods, and Perspectives
ThesisOverexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells
Berger, Audrey; Le Fourn, Valerie; Masternak, Jacqueline et al. · 2020 · Theses · DOI
Full title: Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells
Authors: Berger, Audrey; Le Fourn, Valerie; Masternak, Jacqueline; Regamey, Alexandre; Bodenmann, Iris; Girod, Pierre-Alain; Mermod, Nicolas
ThesisDevelopment and validation of a hybrid model for prediction of viable cell density, titer and cumulative glucose consumption in a mammalian cell culture system
Yatipanthalawa, BS; Wallace Fitzsimons, SE; Horning, T et al. · 2024 · Theses · DOI
Full title: Development and validation of a hybrid model for prediction of viable cell density, titer and cumulative glucose consumption in a mammalian cell culture system
ThesisApplication of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers
Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem et al. · 2019 · Theses · DOI
Full title: Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers
Authors: Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem; Malphettes, Laetitia; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808
ThesisRNA-seq based expression analysis of the CHO cell protein secretion pathway
Lund, Anne Mathilde; Kaas, Christian Schrøder; Kildegaard, Helene Faustrup et al. · 2013 · Theses · DOI
Full title: RNA-seq based expression analysis of the CHO cell protein secretion pathway
Authors: Lund, Anne Mathilde; Kaas, Christian Schrøder; Kildegaard, Helene Faustrup; Kristensen, Claus; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808
ThesisNetwork reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data
Lund, Anne Mathilde; Kaas, Christian Schrøder; Brandl, Julian et al. · 2017 · Theses · DOI
Full title: Network reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data
Authors: Lund, Anne Mathilde; Kaas, Christian Schrøder; Brandl, Julian; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Kildegaard, Helene Faustrup; Kristensen, Claus; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808
Full title: Impact of cellular stress on recombinant monoclonal antibody produced by high yielding Chinese Hamster Ovary (CHO) cell cultures in bioreactors
ThesisUsing titer and titer normalized to confluence are complementary strategies for obtaining Chinese hamster ovary cell lines with high volumetric productivity of etanercept
Pristovšek, Nuša; Hansen, Henning Gram; Sergeeva, Daria et al. · 2018 · Theses · DOI
Full title: Using titer and titer normalized to confluence are complementary strategies for obtaining Chinese hamster ovary cell lines with high volumetric productivity of etanercept
Authors: Pristovšek, Nuša; Hansen, Henning Gram; Sergeeva, Daria; Borth, Nicole; Min Lee, Gyun; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup
ThesisBaicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity
Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard et al. · 2018 · Theses · DOI
Full title: Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity
Authors: Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Kildegaard, Helene Faustrup; Min Lee, Gyun
ThesisImproving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup et al. · 2017 · Theses · DOI
Full title: Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
Authors: Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup; Min Lee, Gyun
ThesisApplication of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers
Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem et al. · 2019 · Theses · DOI
Full title: Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers
Authors: Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem; Malphettes, Laetitia; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808
ThesisRNA-seq based expression analysis of the CHO cell protein secretion pathway
Lund, Anne Mathilde; Kaas, Christian Schrøder; Kildegaard, Helene Faustrup et al. · 2013 · Theses · DOI
Full title: RNA-seq based expression analysis of the CHO cell protein secretion pathway
Authors: Lund, Anne Mathilde; Kaas, Christian Schrøder; Kildegaard, Helene Faustrup; Kristensen, Claus; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808
ThesisNetwork reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data
Lund, Anne Mathilde; Kaas, Christian Schrøder; Brandl, Julian et al. · 2017 · Theses · DOI
Full title: Network reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data
Authors: Lund, Anne Mathilde; Kaas, Christian Schrøder; Brandl, Julian; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Kildegaard, Helene Faustrup; Kristensen, Claus; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808
ThesisImproving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines
Full title: Improving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines
ThesisUntangling the mechanism of 3-methyladenine in enhancing the specific productivity: Transcriptome analysis of recombinant Chinese hamster ovary cells treated with 3-methyladenine
Baek, Eric; Lee, Jae Seong; Min Lee, Gyun · 2018 · Theses · DOI
Full title: Untangling the mechanism of 3-methyladenine in enhancing the specific productivity: Transcriptome analysis of recombinant Chinese hamster ovary cells treated with 3-methyladenine
Authors: Baek, Eric; Lee, Jae Seong; Min Lee, Gyun
ThesisUnraveling productivity-enhancing genes in Chinese hamster ovary cells via CRISPR activation screening using recombinase-mediated cassette exchange system
Baek, Minhye; Kim, Che Lin; Kim, Su Hyun et al. · 2025 · Theses · DOI
Full title: Unraveling productivity-enhancing genes in Chinese hamster ovary cells via CRISPR activation screening using recombinase-mediated cassette exchange system
Authors: Baek, Minhye; Kim, Che Lin; Kim, Su Hyun; la Cour Karottki, Karen Julie; Hefzi, Hooman; id_orcid 0009-0003-4067-6224; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Lewis, Nathan E.; Lee, Jae Seong; Lee, Gyun Min
Full title: Impact of cellular stress on recombinant monoclonal antibody produced by high yielding Chinese Hamster Ovary (CHO) cell cultures in bioreactors
ThesisUsing titer and titer normalized to confluence are complementary strategies for obtaining Chinese hamster ovary cell lines with high volumetric productivity of etanercept
Pristovšek, Nuša; Hansen, Henning Gram; Sergeeva, Daria et al. · 2018 · Theses · DOI
Full title: Using titer and titer normalized to confluence are complementary strategies for obtaining Chinese hamster ovary cell lines with high volumetric productivity of etanercept
Authors: Pristovšek, Nuša; Hansen, Henning Gram; Sergeeva, Daria; Borth, Nicole; Min Lee, Gyun; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup
ThesisNetwork reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data
Lund, Anne Mathilde; Kaas, Christian Schrøder; Brandl, Julian et al. · 2017 · Theses · DOI
Full title: Network reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data
Authors: Lund, Anne Mathilde; Kaas, Christian Schrøder; Brandl, Julian; Pedersen, Lasse Ebdrup; Kildegaard, Helene Faustrup; Kristensen, Claus; Andersen, Mikael Rørdam
ThesisQuantitative Proteomics Analysis of Barley-Based Liquid Feed and the Effect of Protease Inhibitors and NADPH-Dependent Thioredoxin Reductase/Thioredoxin (NTR/Trx) System
Sultan, Abida; Andersen, Birgit; Christensen, Jesper Bjerg et al. · 2019 · Theses · DOI
Full title: Quantitative Proteomics Analysis of Barley-Based Liquid Feed and the Effect of Protease Inhibitors and NADPH-Dependent Thioredoxin Reductase/Thioredoxin (NTR/Trx) System
ThesisBaicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity
Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard et al. · 2018 · Theses · DOI
Full title: Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity
Authors: Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Kildegaard, Helene Faustrup; Min Lee, Gyun
ThesisImproving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup et al. · 2017 · Theses · DOI
Full title: Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
Authors: Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup; Min Lee, Gyun
Full title: Nutritional supplementation to increase growth and paralytic shellfish toxin productivity by the marine dinoflagellate Alexandrium tamarense
Full title: An Unstructured Kinetic Model of Macromolecular Metabolism in Batch and Fed-batch Cultures of Hybridoma Cells Producing Monoclonal Antibody
ThesisEvaluation of the batch kinetics of the amino acid metabolism of a mouse hybridoma and human lymphoblastoid cell line using a pre-column FDNDEA derivitisation, HPLC technique
Marquis, Christopher Peter; Barford, John Patrick; Harbour, Colin et al. · 1996 · Theses · DOI
Full title: Evaluation of the batch kinetics of the amino acid metabolism of a mouse hybridoma and human lymphoblastoid cell line using a pre-column FDNDEA derivitisation, HPLC technique
Authors: Marquis, Christopher Peter; Barford, John Patrick; Harbour, Colin; Nobbs, Denis M.
ThesisUnderstanding the impact of bioprocess conditions on monoclonal antibody glycosylation in mammalian cell cultures through experimental and computational analyses
Full title: Understanding the impact of bioprocess conditions on monoclonal antibody glycosylation in mammalian cell cultures through experimental and computational analyses
ThesisUnraveling productivity-enhancing genes in Chinese hamster ovary cells via CRISPR activation screening using recombinase-mediated cassette exchange system
Baek, Minhye; Kim, Che Lin; Kim, Su Hyun et al. · 2025 · Technical University of Denmark (DTU) · DOI
Full title: Unraveling productivity-enhancing genes in Chinese hamster ovary cells via CRISPR activation screening using recombinase-mediated cassette exchange system
Authors: Baek, Minhye; Kim, Che Lin; Kim, Su Hyun; la Cour Karottki, Karen Julie; Hefzi, Hooman; id_orcid 0009-0003-4067-6224; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Lewis, Nathan E.; Lee, Jae Seong; Lee, Gyun Min
ThesisBaicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity
Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard et al. · 2018 · Technical University of Denmark (DTU) · DOI
Full title: Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity
Authors: Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Kildegaard, Helene Faustrup; Min Lee, Gyun
ThesisImproving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup et al. · 2017 · Technical University of Denmark (DTU) · DOI
Full title: Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
Authors: Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup; Min Lee, Gyun
ThesisDietary protein quality and proper protein to energy ratios: A bioeconomic approach in aquaculture feeding practices
Khan, Kifayat Ullah [UNESP]; Rodrigues, Andressa Tellechea [UNESP]; Mansano, Cleber Fernando Menegasso et al. · 2019 · Universidade Estadual Paulista (UNESP) · DOI
Full title: Dietary protein quality and proper protein to energy ratios: A bioeconomic approach in aquaculture feeding practices
Authors: Khan, Kifayat Ullah [UNESP]; Rodrigues, Andressa Tellechea [UNESP]; Mansano, Cleber Fernando Menegasso; Queiroz, Daniel Monge de Almeida [UNESP]; Sakomura, Nilva Kazue [UNESP]; Romaneli, Rafael de Souza [UNESP]; Do Nascimento, Thiago Matias Torres [UNESP]; Fernandes, João Batista Kochenborger [UNESP]
ThesisMyo-inositol increases respiratory burst, cellular proliferation, and phagocytosis of cultured leukocytes from Nile tilapia
Damasceno Rodrigues, Edgar Junio [UNESP]; Pucci Figueiredo de Carvalho, Pedro Luiz; Silva, Vitor Fernandes et al. · 2025 · Universidade Estadual Paulista (UNESP) · DOI
Full title: Myo-inositol increases respiratory burst, cellular proliferation, and phagocytosis of cultured leukocytes from Nile tilapia
Authors: Damasceno Rodrigues, Edgar Junio [UNESP]; Pucci Figueiredo de Carvalho, Pedro Luiz; Silva, Vitor Fernandes; Gatlin, Delbert M.; Barros, Margarida Maria [UNESP]
ThesisNutritional supplementation to increase growth and paralytic shellfish toxin productivity by the marine dinoflagellate Alexandrium tamarense
Wang, CH; Hsieh, DDP · 2002 · Hong Kong University of Science and Technology (HKUST) · DOI
Full title: Nutritional supplementation to increase growth and paralytic shellfish toxin productivity by the marine dinoflagellate Alexandrium tamarense
Authors: Wang, CH; Hsieh, DDP
Year: 2002
Venue: Hong Kong University of Science and Technology (HKUST)
ThesisAn Unstructured Kinetic Model of Macromolecular Metabolism in Batch and Fed-batch Cultures of Hybridoma Cells Producing Monoclonal Antibody
Jang, DJ; Barford, JP · 2000 · Hong Kong University of Science and Technology (HKUST) · DOI
Full title: An Unstructured Kinetic Model of Macromolecular Metabolism in Batch and Fed-batch Cultures of Hybridoma Cells Producing Monoclonal Antibody
Authors: Jang, DJ; Barford, JP
Year: 2000
Venue: Hong Kong University of Science and Technology (HKUST)
ThesisOverexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells
Berger, Audrey; Le Fourn, Valerie; Masternak, Jacqueline et al. · 2020 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells
Authors: Berger, Audrey; Le Fourn, Valerie; Masternak, Jacqueline; Regamey, Alexandre; Bodenmann, Iris; Girod, Pierre-Alain; Mermod, Nicolas
Year: 2020
Venue: École polytechnique fédérale de Lausanne (EPFL)
ThesisManufacture of Recombinant Therapeutic Proteins Using Chinese Hamster Ovary Cells in Large-Scale Bioreactors History, Methods, and Perspectives
Wurm, Florian Maria; de Jesus, Maria · 2025 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Manufacture of Recombinant Therapeutic Proteins Using Chinese Hamster Ovary Cells in Large-Scale Bioreactors History, Methods, and Perspectives
Authors: Wurm, Florian Maria; de Jesus, Maria
Year: 2025
Venue: École polytechnique fédérale de Lausanne (EPFL)
ThesisA comparison of orbitally-shaken and stirred-tank bioreactors: pH modulation and bioreactor type affect CHO cell growth and protein glycosylation
Monteil, Dominique T.; Juvet, Valentin; Paz, Jonathan et al. · 2017 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: A comparison of orbitally-shaken and stirred-tank bioreactors: pH modulation and bioreactor type affect CHO cell growth and protein glycosylation
Authors: Monteil, Dominique T.; Juvet, Valentin; Paz, Jonathan; Moniatte, Marc; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.
Year: 2017
Venue: École polytechnique fédérale de Lausanne (EPFL)
ThesisApplication of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers
Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem et al. · 2019 · Technical University of Denmark (DTU) · DOI
Full title: Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers
Authors: Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem; Malphettes, Laetitia; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808
ThesisRNA-seq based expression analysis of the CHO cell protein secretion pathway
Lund, Anne Mathilde; Kaas, Christian Schrøder; Kildegaard, Helene Faustrup et al. · 2013 · Technical University of Denmark (DTU) · DOI
Full title: RNA-seq based expression analysis of the CHO cell protein secretion pathway
Authors: Lund, Anne Mathilde; Kaas, Christian Schrøder; Kildegaard, Helene Faustrup; Kristensen, Claus; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808
ThesisUntangling the mechanism of 3-methyladenine in enhancing the specific productivity: Transcriptome analysis of recombinant Chinese hamster ovary cells treated with 3-methyladenine
Baek, Eric; Lee, Jae Seong; Min Lee, Gyun · 2018 · Technical University of Denmark (DTU) · DOI
Full title: Untangling the mechanism of 3-methyladenine in enhancing the specific productivity: Transcriptome analysis of recombinant Chinese hamster ovary cells treated with 3-methyladenine
Authors: Baek, Eric; Lee, Jae Seong; Min Lee, Gyun
ThesisImproving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines
Kim, Che Lin; Min Lee, Gyun · 2019 · Technical University of Denmark (DTU) · DOI
Full title: Improving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines
ThesisImpact of cellular stress on recombinant monoclonal antibody produced by high yielding Chinese Hamster Ovary (CHO) cell cultures in bioreactors
Chevallier, Valentine · 2020 · Technical University of Denmark (DTU) · DOI
Full title: Impact of cellular stress on recombinant monoclonal antibody produced by high yielding Chinese Hamster Ovary (CHO) cell cultures in bioreactors
ThesisApplication of CRISPR/Cas9 Genome Editing to Improve Recombinant Protein Production in CHO Cells
Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Rojek, Johan Blatt et al. · 2025 · Technical University of Denmark (DTU) · DOI
Full title: Application of CRISPR/Cas9 Genome Editing to Improve Recombinant Protein Production in CHO Cells
Authors: Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Rojek, Johan Blatt; la Cour Karottki, Karen Julie; Lee, Jae Seong; Kildegaard, Helene Faustrup
ThesisCompartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells
Pérez-Rodriguez, Saumel; Wulff, Tune; Voldborg, Bjørn G et al. · 2021 · Technical University of Denmark (DTU) · DOI
Full title: Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells
ThesisUsing titer and titer normalized to confluence are complementary strategies for obtaining Chinese hamster ovary cell lines with high volumetric productivity of etanercept
Pristovšek, Nuša; Hansen, Henning Gram; Sergeeva, Daria et al. · 2018 · Technical University of Denmark (DTU) · DOI
Full title: Using titer and titer normalized to confluence are complementary strategies for obtaining Chinese hamster ovary cell lines with high volumetric productivity of etanercept
Authors: Pristovšek, Nuša; Hansen, Henning Gram; Sergeeva, Daria; Borth, Nicole; Min Lee, Gyun; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup
ThesisApplication of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers
Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem et al. · 2019 · Technical University of Denmark (DTU) · DOI
Full title: Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers
Authors: Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem; Malphettes, Laetitia; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808
ThesisRNA-seq based expression analysis of the CHO cell protein secretion pathway
Lund, Anne Mathilde; Kaas, Christian Schrøder; Kildegaard, Helene Faustrup et al. · 2013 · Technical University of Denmark (DTU) · DOI
Full title: RNA-seq based expression analysis of the CHO cell protein secretion pathway
Authors: Lund, Anne Mathilde; Kaas, Christian Schrøder; Kildegaard, Helene Faustrup; Kristensen, Claus; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808
ThesisImpact of cellular stress on recombinant monoclonal antibody produced by high yielding Chinese Hamster Ovary (CHO) cell cultures in bioreactors
Chevallier, Valentine · 2020 · Technical University of Denmark (DTU) · DOI
Full title: Impact of cellular stress on recombinant monoclonal antibody produced by high yielding Chinese Hamster Ovary (CHO) cell cultures in bioreactors
ThesisCompartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells
Pérez-Rodriguez, Saumel; Wulff, Tune; Voldborg, Bjørn G et al. · 2021 · Technical University of Denmark (DTU) · DOI
Full title: Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells
ThesisUsing titer and titer normalized to confluence are complementary strategies for obtaining Chinese hamster ovary cell lines with high volumetric productivity of etanercept
Pristovšek, Nuša; Hansen, Henning Gram; Sergeeva, Daria et al. · 2018 · Technical University of Denmark (DTU) · DOI
Full title: Using titer and titer normalized to confluence are complementary strategies for obtaining Chinese hamster ovary cell lines with high volumetric productivity of etanercept
Authors: Pristovšek, Nuša; Hansen, Henning Gram; Sergeeva, Daria; Borth, Nicole; Min Lee, Gyun; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup
ThesisBaicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity
Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard et al. · 2018 · Technical University of Denmark (DTU) · DOI
Full title: Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity
Authors: Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Kildegaard, Helene Faustrup; Min Lee, Gyun
ThesisImproving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup et al. · 2017 · Technical University of Denmark (DTU) · DOI
Full title: Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
Authors: Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup; Min Lee, Gyun
ThesisDietary macronutrients, endocrine functioning and intermediary metabolism in broiler chickens - Pair wise substitutions between protein, fat and carbohydrate
Malheiros, R. D.; Moraes, VMB; Collin, A. et al. · 2014 · Universidade Estadual Paulista (UNESP) · DOI
Full title: Dietary macronutrients, endocrine functioning and intermediary metabolism in broiler chickens - Pair wise substitutions between protein, fat and carbohydrate
Authors: Malheiros, R. D.; Moraes, VMB; Collin, A.; Janssens, GPJ; Decuypere, E.; Buyse, J.
Growth hormone regulation of DNA replication, but not insulin production, is partly mediated by somatomedin-C/insulin-like growth factor I in isolated pancreatic islets from adult rats
I. Swenne, D. Hill · 1989
Full title: Growth hormone regulation of DNA replication, but not insulin production, is partly mediated by somatomedin-C/insulin-like growth factor I in isolated pancreatic islets from adult rats
Combination of strong anion exchange liquid chromatography with microchip capillary electrophoresis sodium dodecyl sulfate for rapid two-dimensional separations of complex protein mixtures
Zagst, Holger, Elgert, Christin, Behrends, Sönke, Wätzig, Hermann · 2021
Full title: Combination of strong anion exchange liquid chromatography with microchip capillary electrophoresis sodium dodecyl sulfate for rapid two-dimensional separations of complex protein mixtures
Authors: Zagst, Holger, Elgert, Christin, Behrends, Sönke, Wätzig, Hermann
Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production
Full title: Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production
Compartment-specific metabolome labeling enables the identification of subcellular fluxes that may serve as promising metabolic engineering targets in CHO cells
Full title: Compartment-specific metabolome labeling enables the identification of subcellular fluxes that may serve as promising metabolic engineering targets in CHO cells
Culture media selection and feeding strategy for high titer production of a lentiviral vector by stable producer clones cultivated at high cell density
Full title: Culture media selection and feeding strategy for high titer production of a lentiviral vector by stable producer clones cultivated at high cell density
Full title: Enhancement of recombinant human IL-24 (rhIL-24) protein production from site-specific integrated engineered CHO cells by sodium butyrate treatment.
Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins
Wolnick, Nicolas, Dickson, Marissa, Webster, Thaddaeus A., Connolly, Roger P., Fernandes, Nancy, Encheva, Vesela, Crittenden, Hunter, Hodgkins, Jessica, Hadley, Brian C., Palermo, Gabriella, Hendrick, Shannon, Newell, Roy A., Gray, Genevieve, Siltanen, Christian, Armstrong, Julia, Downey, Brandon, Mason, Carrie · 2024
Full title: Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins
Authors: Wolnick, Nicolas, Dickson, Marissa, Webster, Thaddaeus A., Connolly, Roger P., Fernandes, Nancy, Encheva, Vesela, Crittenden, Hunter, Hodgkins, Jessica, Hadley, Brian C., Palermo, Gabriella, Hendrick, Shannon, Newell, Roy A., Gray, Genevieve, Siltanen, Christian, Armstrong, Julia, Downey, Brandon, Mason, Carrie
Honey bee colonies provided with natural forage have lower pathogen loads and higher overwinter survival than those fed protein supplements
G. DeGrandi-Hoffman, Yanping Chen, R. Rivera, M. Carroll, Mona Chambers, Geoffrey Hidalgo, Emily Watkins Jong · 2015
Full title: Honey bee colonies provided with natural forage have lower pathogen loads and higher overwinter survival than those fed protein supplements
Authors: G. DeGrandi-Hoffman, Yanping Chen, R. Rivera, M. Carroll, Mona Chambers, Geoffrey Hidalgo, Emily Watkins Jong
Dietary L-arginine supplementation improves the intestinal development through increasing mucosal Akt and mammalian target of rapamycin signals in intra-uterine growth retarded piglets.
Yuanxiao Wang, Lili Zhang, Genlai Zhou, Zhiyong Liao, H. Ahmad, Wen‐bin Liu, Tian Wang · 2012
Full title: Dietary L-arginine supplementation improves the intestinal development through increasing mucosal Akt and mammalian target of rapamycin signals in intra-uterine growth retarded piglets.
Authors: Yuanxiao Wang, Lili Zhang, Genlai Zhou, Zhiyong Liao, H. Ahmad, Wen‐bin Liu, Tian Wang
Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
Gutierrez, Jahir M., Feizi, Amir, Li, Shangzhong, Kallehauge, Thomas Beuchert, Hefzi, Hooman, Grav, Lise Marie, Ley, Daniel, Hızal, Deniz Baycın, Betenbaugh, Michael J., Voldborg, Björn G., Kildegaard, Helene Faustrup, Lee, Gyun Min, Palsson, Bernhard Ø., Nielsen, Jens, Lewis, Nathan E. · 2020
Full title: Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
Authors: Gutierrez, Jahir M., Feizi, Amir, Li, Shangzhong, Kallehauge, Thomas Beuchert, Hefzi, Hooman, Grav, Lise Marie, Ley, Daniel, Hızal, Deniz Baycın, Betenbaugh, Michael J., Voldborg, Björn G., Kildegaard, Helene Faustrup, Lee, Gyun Min, Palsson, Bernhard Ø., Nielsen, Jens, Lewis, Nathan E.
Effect of cereal soaking and carbohydrase supplementation on growth, nutrient digestibility and intestinal microbiota in liquid-fed grow-finishing pigs.
Torres-Pitarch, Alberto, Gardiner, Gillian E, Cormican, Paul, Rea, Mary, Crispie, Fiona, O'Doherty, John V, Cozannet, Pierre, Ryan, Tomas, Lawlor, Peadar G · 2020
Full title: Effect of cereal soaking and carbohydrase supplementation on growth, nutrient digestibility and intestinal microbiota in liquid-fed grow-finishing pigs.
Authors: Torres-Pitarch, Alberto, Gardiner, Gillian E, Cormican, Paul, Rea, Mary, Crispie, Fiona, O'Doherty, John V, Cozannet, Pierre, Ryan, Tomas, Lawlor, Peadar G
Improved performance of a rainbow trout selected strain is associated with protein digestion rates and synchronization of amino acid absorption.
Brezas, Andreas, Hardy, Ronald W · 2020
Full title: Improved performance of a rainbow trout selected strain is associated with protein digestion rates and synchronization of amino acid absorption.
Development of serum-free and grain-derived-nutrient-free medium using microalga-derived nutrients and mammalian cell-secreted growth factors for sustainable cultured meat production
Full title: Development of serum-free and grain-derived-nutrient-free medium using microalga-derived nutrients and mammalian cell-secreted growth factors for sustainable cultured meat production
Guokai Yan, R. Lestari, Baisheng Long, Qiwen Fan, Zhichang Wang, Xiaozhen Guo, Jie Yu, Jun Hu, Xingya Yang, Changqing Chen, Lu Liu, Xiuzhi Li, A. Purnomoadi, J. Achmadi, Xianghua Yan · 2016
Full title: Comparative Proteomics Analysis Reveals L-Arginine Activates Ethanol Degradation Pathways in HepG2 Cells
Authors: Guokai Yan, R. Lestari, Baisheng Long, Qiwen Fan, Zhichang Wang, Xiaozhen Guo, Jie Yu, Jun Hu, Xingya Yang, Changqing Chen, Lu Liu, Xiuzhi Li, A. Purnomoadi, J. Achmadi, Xianghua Yan
Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion
Kallehauge, Thomas Beuchert, Li, Shangzhong, Pedersen, Lasse Ebdrup, Ha, Tae Kwang, Ley, Daniel, Andersen, Mikael Rørdam, Kildegaard, Helene Faustrup, Lee, Gyun Min, Lewis, Nathan E. · 2017
Full title: Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion
Authors: Kallehauge, Thomas Beuchert, Li, Shangzhong, Pedersen, Lasse Ebdrup, Ha, Tae Kwang, Ley, Daniel, Andersen, Mikael Rørdam, Kildegaard, Helene Faustrup, Lee, Gyun Min, Lewis, Nathan E.
Supply of methionine and arginine alters phosphorylation of mechanistic target of rapamycin (mTOR), circadian clock proteins, and α-s1-casein abundance in bovine mammary epithelial cells.
Liangyu Hu, Yifei Chen, Ismael M Cortes, D. Coleman, H. Dai, Yusheng Liang, C. Parys, C. Fernández, Mengzhi Wang, J. Loor · 2020
Full title: Supply of methionine and arginine alters phosphorylation of mechanistic target of rapamycin (mTOR), circadian clock proteins, and α-s1-casein abundance in bovine mammary epithelial cells.
Authors: Liangyu Hu, Yifei Chen, Ismael M Cortes, D. Coleman, H. Dai, Yusheng Liang, C. Parys, C. Fernández, Mengzhi Wang, J. Loor
Metabolic flux analysis: a comprehensive review on sample preparation, analytical techniques, data analysis, computational modelling, and main application areas
Falco, Bruna de, Giannino, Francesco, Cartenì, Fabrizio, Mazzoleni, Stefano, Kim, Dong‐Hyun · 2022
Full title: Metabolic flux analysis: a comprehensive review on sample preparation, analytical techniques, data analysis, computational modelling, and main application areas
Authors: Falco, Bruna de, Giannino, Francesco, Cartenì, Fabrizio, Mazzoleni, Stefano, Kim, Dong‐Hyun
The influence of force feeding and of protein supplementation to the diet on the metabolisable energy of diets, digestibility of nutrients, nitrogen retention and digestive enzymes output in geese.
Nir, I, Nitsan, Z, Vax, A · 1973
Full title: The influence of force feeding and of protein supplementation to the diet on the metabolisable energy of diets, digestibility of nutrients, nitrogen retention and digestive enzymes output in geese.
The effect of supplemental propionate on insulin responsiveness to glucose and tissue responsiveness to insulin in relation to feeding in sheep.
Sano, H, Terashima, Y · 1998
Full title: The effect of supplemental propionate on insulin responsiveness to glucose and tissue responsiveness to insulin in relation to feeding in sheep.
Glycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster ovary fed-batch cultures
Hutter, Sandro, Villiger, Thomas K., Brühlmann, David, Stettler, Matthieu, Broly, Hervé, Šoóš, Miroslav, Gunawan, Rudiyanto · 2017
Full title: Glycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster ovary fed-batch cultures
Authors: Hutter, Sandro, Villiger, Thomas K., Brühlmann, David, Stettler, Matthieu, Broly, Hervé, Šoóš, Miroslav, Gunawan, Rudiyanto
Essentially leading antibody production: An investigation of amino acids, myeloma and natural V-region signal peptides in producing Pertuzumab and Trastuzumab variants
Ling, Wei‐Li, Su, Chinh Tran-To, Lua, Wai‐Heng, Poh, Jun-Jie, Ng, Yuen-Ling, Wipat, Anil, Gan, Samuel Ken‐En · 2020
Full title: Essentially leading antibody production: An investigation of amino acids, myeloma and natural V-region signal peptides in producing Pertuzumab and Trastuzumab variants
Authors: Ling, Wei‐Li, Su, Chinh Tran-To, Lua, Wai‐Heng, Poh, Jun-Jie, Ng, Yuen-Ling, Wipat, Anil, Gan, Samuel Ken‐En
Evaluating the potential of marine invertebrate and insect protein hydrolysates to reduce fetal bovine serum in cell culture media for cultivated fish production
Full title: Evaluating the potential of marine invertebrate and insect protein hydrolysates to reduce fetal bovine serum in cell culture media for cultivated fish production
Temporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch and Perfusion Bioreactor Operation
Gyorgypal, Aron, Fratz‐Berilla, Erica J., Kohnhorst, Casey, Powers, David N., Chundawat, Shishir P. S. · 2023
Full title: Temporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch and Perfusion Bioreactor Operation
Authors: Gyorgypal, Aron, Fratz‐Berilla, Erica J., Kohnhorst, Casey, Powers, David N., Chundawat, Shishir P. S.
Evaluation of Plant- and Microbial-Derived Protein Hydrolysates as Substitutes for Fetal Bovine Serum in Cultivated Seafood Cell Culture Media
Arian Amirvaresi, Reza Ovissipour · 2024
Full title: Evaluation of Plant- and Microbial-Derived Protein Hydrolysates as Substitutes for Fetal Bovine Serum in Cultivated Seafood Cell Culture Media
Comparing Kinetic versus Stoichiometric Priorities in Hybrid Models of CHO Metabolism
Khare, Pratik, Ndahiro, Nelson, Klaubert, Stephanie R., Ma, Edward, Bertalan, Tom, Kevrekidis, Ioannis G., Harcum, Sarah W., Betenbaugh, Michael J. · 2025
Full title: Comparing Kinetic versus Stoichiometric Priorities in Hybrid Models of CHO Metabolism
Authors: Khare, Pratik, Ndahiro, Nelson, Klaubert, Stephanie R., Ma, Edward, Bertalan, Tom, Kevrekidis, Ioannis G., Harcum, Sarah W., Betenbaugh, Michael J.
Full title: Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family.
Synergizing metabolic flux analysis and nucleotide sugar metabolism to understand the control of glycosylation of recombinant protein in CHO cells
Burleigh, Susan C, Laar, Teun van de, Stroop, Corné J.M., Grunsven, Wout MJ van, O’Donoghue, Niaobh, Rudd, Pauline M., Davey, Gavin P. · 2011
Full title: Synergizing metabolic flux analysis and nucleotide sugar metabolism to understand the control of glycosylation of recombinant protein in CHO cells
Authors: Burleigh, Susan C, Laar, Teun van de, Stroop, Corné J.M., Grunsven, Wout MJ van, O’Donoghue, Niaobh, Rudd, Pauline M., Davey, Gavin P.
Full title: Trace element associated reduction of norleucine and norvaline accumulation during oxygen limitation in a recombinant Escherichia coli fermentation
Selective deposition of dietary α-lipoic acid in mitochondrial fraction and its synergistic effect with α-tocoperhol acetate on broiler meat oxidative stability.
Parveen, Rashida, Asghar, Ali, Anjum, Faqir M, Khan, Muhammad I, Arshad, Muhammad Sajid, Yasmeen, Ammara · 2013
Full title: Selective deposition of dietary α-lipoic acid in mitochondrial fraction and its synergistic effect with α-tocoperhol acetate on broiler meat oxidative stability.
Authors: Parveen, Rashida, Asghar, Ali, Anjum, Faqir M, Khan, Muhammad I, Arshad, Muhammad Sajid, Yasmeen, Ammara
Effect of anionic salt and highly fermentable carbohydrate supplementations on urine pH and on experimentally induced hypocalcaemia in cows.
Mellau, L S B, Jørgensen, R J, Bartlett, P C, Enemark, J M D, Hansen, A K · 2004
Full title: Effect of anionic salt and highly fermentable carbohydrate supplementations on urine pH and on experimentally induced hypocalcaemia in cows.
Authors: Mellau, L S B, Jørgensen, R J, Bartlett, P C, Enemark, J M D, Hansen, A K
Rumen-protected conjugated linoleic acid supplementation to dairy cows in late pregnancy and early lactation: effects on milk composition, milk yield, blood metabolites and gene expression in liver.
Sigl, Tanja, Schlamberger, Gregor, Kienberger, Hermine, Wiedemann, Steffi, Meyer, Heinrich Hd, Kaske, Martin · 2010
Full title: Rumen-protected conjugated linoleic acid supplementation to dairy cows in late pregnancy and early lactation: effects on milk composition, milk yield, blood metabolites and gene expression in liver.
Authors: Sigl, Tanja, Schlamberger, Gregor, Kienberger, Hermine, Wiedemann, Steffi, Meyer, Heinrich Hd, Kaske, Martin
Non-stationary 13C metabolic flux analysis of Chinese hamster ovary cells in batch culture using extracellular labeling highlights metabolic reversibility and compartmentation
Full title: Non-stationary 13C metabolic flux analysis of Chinese hamster ovary cells in batch culture using extracellular labeling highlights metabolic reversibility and compartmentation
Carnitine deficiency presenting with a decreased mental state in a patient with amyotrophic lateral sclerosis receiving long-term tube feeding: a case report.
Full title: Carnitine deficiency presenting with a decreased mental state in a patient with amyotrophic lateral sclerosis receiving long-term tube feeding: a case report.
Analysis of glycolytic flux as a rapid screen to identify low lactate producing CHO cell lines with desirable monoclonal antibody yield and glycan profile
Legmann, Rachel, melito, Julie, Belzer, Ilana, Ferrick, David A. · 2011
Full title: Analysis of glycolytic flux as a rapid screen to identify low lactate producing CHO cell lines with desirable monoclonal antibody yield and glycan profile
Authors: Legmann, Rachel, melito, Julie, Belzer, Ilana, Ferrick, David A.
First CpG island microarray for genome-wide analyses of DNA methylation in Chinese hamster ovary cells: new insights into the epigenetic answer to butyrate treatment
Anna Wippermann, S. Klausing, O. Rupp, T. Noll, R. Hoffrogge · 2013
Full title: First CpG island microarray for genome-wide analyses of DNA methylation in Chinese hamster ovary cells: new insights into the epigenetic answer to butyrate treatment
Authors: Anna Wippermann, S. Klausing, O. Rupp, T. Noll, R. Hoffrogge
Effects of creep feeding and supplemental glutamine or glutamine plus glutamate (Aminogut) on pre- and post-weaning growth performance and intestinal health of piglets
R. Cabrera, J. Usry, Consuelo Arrellano, E. Nogueira, M. Kutschenko, A. Moeser, J. Odle · 2013
Full title: Effects of creep feeding and supplemental glutamine or glutamine plus glutamate (Aminogut) on pre- and post-weaning growth performance and intestinal health of piglets
Authors: R. Cabrera, J. Usry, Consuelo Arrellano, E. Nogueira, M. Kutschenko, A. Moeser, J. Odle
Abstracts from the 26th European Society for Animal Cell Technology Meeting - Cell culture technologies: bridging academia and industry to provide solutions for patients
Full title: Abstracts from the 26th European Society for Animal Cell Technology Meeting - Cell culture technologies: bridging academia and industry to provide solutions for patients
Insights into the roles of exogenous phenylalanine and tyrosine in improving rapamycin production of Streptomyces rapamycinicus with transcriptome analysis
Full title: Insights into the roles of exogenous phenylalanine and tyrosine in improving rapamycin production of Streptomyces rapamycinicus with transcriptome analysis
Experimental studies from shake flasks to 3 L stirred tank bioreactor of nutrients and oxygen supply conditions to improve the growth of the avian cell line DuckCelt®-T17.
Tingaud, Valentine, Bordes, Claire, Al Mouazen, Eyad, Cogné, Claudia, Bolzinger, Marie-Alexandrine, Lawton, Philippe · 2023
Full title: Experimental studies from shake flasks to 3 L stirred tank bioreactor of nutrients and oxygen supply conditions to improve the growth of the avian cell line DuckCelt®-T17.
Authors: Tingaud, Valentine, Bordes, Claire, Al Mouazen, Eyad, Cogné, Claudia, Bolzinger, Marie-Alexandrine, Lawton, Philippe
Systematically programmed adaptive evolution reveals potential role of carbon and nitrogen pathways during lipid accumulation in Chlamydomonas reinhardtii
Velmurugan, Natarajan, Sung, Minji, Yim, Sung Sun, Park, Min S., Yang, Ji Won, Jeong, Ki Jun · 2014
Full title: Systematically programmed adaptive evolution reveals potential role of carbon and nitrogen pathways during lipid accumulation in Chlamydomonas reinhardtii
Authors: Velmurugan, Natarajan, Sung, Minji, Yim, Sung Sun, Park, Min S., Yang, Ji Won, Jeong, Ki Jun
Hydrolyzed fish proteins reduced activation of caspase-3 in H2O2 induced oxidative stressed liver cells isolated from Atlantic salmon (Salmo salar)
M. Espe, E. Holen, J. He, F. Provan, L. Chen, K. B. Øysæd, J. Seliussen · 2015
Full title: Hydrolyzed fish proteins reduced activation of caspase-3 in H2O2 induced oxidative stressed liver cells isolated from Atlantic salmon (Salmo salar)
Authors: M. Espe, E. Holen, J. He, F. Provan, L. Chen, K. B. Øysæd, J. Seliussen
Dietary supplementation with free methionine or methionine dipeptide mitigates intestinal oxidative stress induced by Eimeria spp. challenge in broiler chickens
A. Khatlab, A. P. Del Vesco, A. R. de Oliveira Neto, R. P. Fernandes, E. Gasparino · 2019
Full title: Dietary supplementation with free methionine or methionine dipeptide mitigates intestinal oxidative stress induced by Eimeria spp. challenge in broiler chickens
Authors: A. Khatlab, A. P. Del Vesco, A. R. de Oliveira Neto, R. P. Fernandes, E. Gasparino
Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment
Full title: Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment
Responses of CHO-DHFR cells to ratio of asparagine to glutamine in feed media: cell growth, antibody production, metabolic waste, glutamate, and energy metabolism
Full title: Responses of CHO-DHFR cells to ratio of asparagine to glutamine in feed media: cell growth, antibody production, metabolic waste, glutamate, and energy metabolism
Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process
Morris, Caitlin, Polanco, Ashli, Yongky, Andrew, Xu, Jianlin, Huang, Zhuangrong, Zhao, Jia, McFarland, Kevin S., Park, Seo‐Young, Warrack, Bethanne M., Reily, Michael D., Borys, Michael, Li, Zheng Jian, Yoon, Seongkyu · 2020
Full title: Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process
Authors: Morris, Caitlin, Polanco, Ashli, Yongky, Andrew, Xu, Jianlin, Huang, Zhuangrong, Zhao, Jia, McFarland, Kevin S., Park, Seo‐Young, Warrack, Bethanne M., Reily, Michael D., Borys, Michael, Li, Zheng Jian, Yoon, Seongkyu
Experimental and In Silico Modelling Analyses of the Gene Expression Pathway for Recombinant Antibody and By-Product Production in NS0 Cell Lines
Mead, Emma J., Chiverton, Lesley M., Spurgeon, Sarah K., Martin, Elaine, Montague, G.A., Smales, C. Mark, Haar, Tobias von der · 2012
Full title: Experimental and In Silico Modelling Analyses of the Gene Expression Pathway for Recombinant Antibody and By-Product Production in NS0 Cell Lines
Authors: Mead, Emma J., Chiverton, Lesley M., Spurgeon, Sarah K., Martin, Elaine, Montague, G.A., Smales, C. Mark, Haar, Tobias von der
Availability of Amino Acids Extends Chronological Lifespan by Suppressing Hyper-Acidification of the Environment in Saccharomyces cerevisiae
Y. Maruyama, T. Ito, H. Kodama, A. Matsuura · 2016
Full title: Availability of Amino Acids Extends Chronological Lifespan by Suppressing Hyper-Acidification of the Environment in Saccharomyces cerevisiae
Authors: Y. Maruyama, T. Ito, H. Kodama, A. Matsuura
Comparison of secretory signal peptides for heterologous protein expression in microalgae: Expanding the secretion portfolio for Chlamydomonas reinhardtii
Molino, João Vitor Dutra, Carvalho, João Carlos Monteiro de, Mayfield, Stephen P. · 2018
Full title: Comparison of secretory signal peptides for heterologous protein expression in microalgae: Expanding the secretion portfolio for Chlamydomonas reinhardtii
Authors: Molino, João Vitor Dutra, Carvalho, João Carlos Monteiro de, Mayfield, Stephen P.
Full title: High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells
Evidence for co-translational misincorporation of non-canonical amino acid hydroxyproline in recombinant antibodies produced in Chinese Hamster Ovary (CHO) cell lines
Boddapati, Shanta, Gilmore, Jason M., Boone, Kyle, Bushey, John, Ross, Jonathan, Gfeller, Brian, McFee, William A., Rao, Romesh, Corrigan, Greg, Chen, Aaron, Clarke, Howard R. G., Valliere‐Douglass, John, Bhargava, Swapnil · 2020
Full title: Evidence for co-translational misincorporation of non-canonical amino acid hydroxyproline in recombinant antibodies produced in Chinese Hamster Ovary (CHO) cell lines
Authors: Boddapati, Shanta, Gilmore, Jason M., Boone, Kyle, Bushey, John, Ross, Jonathan, Gfeller, Brian, McFee, William A., Rao, Romesh, Corrigan, Greg, Chen, Aaron, Clarke, Howard R. G., Valliere‐Douglass, John, Bhargava, Swapnil
Enhanced recombinant protein production in CHO cell continuous cultures under growth-inhibiting conditions is associated with an arrested cell cycle in G1/G0 phase.
Full title: Enhanced recombinant protein production in CHO cell continuous cultures under growth-inhibiting conditions is associated with an arrested cell cycle in G1/G0 phase.
Supplementing dairy feed by dicalcium phosphate and effect on dry matter intake, digestibility, milk composition, and blood mineral balances in crossbred dairy cows.
Full title: Supplementing dairy feed by dicalcium phosphate and effect on dry matter intake, digestibility, milk composition, and blood mineral balances in crossbred dairy cows.
Proteomics Profiling of Chimeric-Truncated Tissue Plasminogen activator Producing- Chinese Hamster Ovary Cells Cultivated in a Chemically Defined Medium Supplemented with Protein Hydrolysates
B. Azarian, Seyedeh Matin Sajedin, A. Azimi, M. Raigani, B. Vaziri, Fatemeh Davami · 2017
Full title: Proteomics Profiling of Chimeric-Truncated Tissue Plasminogen activator Producing- Chinese Hamster Ovary Cells Cultivated in a Chemically Defined Medium Supplemented with Protein Hydrolysates
Authors: B. Azarian, Seyedeh Matin Sajedin, A. Azimi, M. Raigani, B. Vaziri, Fatemeh Davami
Supplementing D-Type and L-Type Methionine and Its Precursor Alters the Expression of mRNA, Proteins and Metabolites Involved in Milk Protein Synthesis and Energy Metabolism in Bovine Mammary Cells
S. Jeon, J. R. Conejos, Jungeun Kim, Min-Jeong Kim, Jeong-Eun Lee, B. S. Lee, Park Jinseung, J. Moon, Jae-Sung Lee, Hong-Gu Lee · 2018
Full title: Supplementing D-Type and L-Type Methionine and Its Precursor Alters the Expression of mRNA, Proteins and Metabolites Involved in Milk Protein Synthesis and Energy Metabolism in Bovine Mammary Cells
Authors: S. Jeon, J. R. Conejos, Jungeun Kim, Min-Jeong Kim, Jeong-Eun Lee, B. S. Lee, Park Jinseung, J. Moon, Jae-Sung Lee, Hong-Gu Lee
Supplementing L-Isoleucine Increases Medium Protein and Alters the Expression of Genes and Proteins Involved in Milk Protein Synthesis and Energy Metabolism in Bovine Mammary Cells
J. R. Conejos, Jae-Sung Lee, Jin-Seung Park, J. Moon, Hong-Gu Lee · 2019
Full title: Supplementing L-Isoleucine Increases Medium Protein and Alters the Expression of Genes and Proteins Involved in Milk Protein Synthesis and Energy Metabolism in Bovine Mammary Cells
Authors: J. R. Conejos, Jae-Sung Lee, Jin-Seung Park, J. Moon, Hong-Gu Lee
Full title: Deciphering Metabolic Pathways in High Seeding Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective
Effect of dietary tryptophan supplementation on growth, body composition and digestive enzymes activity of juvenile silver pompano Trachinotus blochii (Lacepede, 1801)
Meenu Devassykutty, Boby Ignatius, V. P., S. Ebeneezar, P. Sawant, B. A. M., E. Varghese, S. P., Sajina K.A · 2022
Full title: Effect of dietary tryptophan supplementation on growth, body composition and digestive enzymes activity of juvenile silver pompano Trachinotus blochii (Lacepede, 1801)
Authors: Meenu Devassykutty, Boby Ignatius, V. P., S. Ebeneezar, P. Sawant, B. A. M., E. Varghese, S. P., Sajina K.A
Dietary Prebiotics and Probiotics Influence the Growth Performance, Feed Utilisation, and Body Indices of Snakehead (Channa striata) Fingerlings.
Munir, Mohammad Bodrul, Hashim, Roshada, Abdul Manaf, Mohammad Suhaimee, Nor, Siti Azizah Mohd · 2016
Full title: Dietary Prebiotics and Probiotics Influence the Growth Performance, Feed Utilisation, and Body Indices of Snakehead (Channa striata) Fingerlings.
Authors: Munir, Mohammad Bodrul, Hashim, Roshada, Abdul Manaf, Mohammad Suhaimee, Nor, Siti Azizah Mohd
Full title: The Epigenetic Regulation of Blinatumomab Gene Expression: Tumor Cell-dependent T cell Response against Lymphoma Cells and Cytotoxic Activity.
Dietary Taurine Improves The Growth Performance, Health Status and Liver Histopathology of Meagre (Argyrosomus Regius) Fed A Reduced Fish Meal Diet
Derya Güroy, Onur Karadal, Betül Güroy, Y. Emre, N. Emre, Durali Eraslan, F. B. Yalım, Serhan Mantoğlu, Abdullah Demir · 2024
Full title: Dietary Taurine Improves The Growth Performance, Health Status and Liver Histopathology of Meagre (Argyrosomus Regius) Fed A Reduced Fish Meal Diet
Authors: Derya Güroy, Onur Karadal, Betül Güroy, Y. Emre, N. Emre, Durali Eraslan, F. B. Yalım, Serhan Mantoğlu, Abdullah Demir
Full title: Ouantitative Proteomic Analysis of Cellular Responses to a Designed Amino Acid Feed in a Monoclonal Antibody Producing Chinese Hamster Ovary Cell Line
Full title: Effects of dietary resveratrol supplementation on digestive enzymes activities and serum biochemistry of rainbow trout (Oncorhynchus mykiss).
Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments
Bayer, Benjamin, Duerkop, Mark, Striedner, Gerald, Sissolak, Bernhard · 2021
Full title: Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments
Authors: Bayer, Benjamin, Duerkop, Mark, Striedner, Gerald, Sissolak, Bernhard
Sodium acetate increases the productivity of HEK293 cells expressing the ECD-Her1 protein in batch cultures: experimental results and metabolic flux analysis
Pérez-Fernández, Bárbara Ariane, Calzadilla, Lisandra, Bena, Chiara Enrico, Giudice, Marco Del, Bosia, Carla, Boggiano-Ayo, Tammy, Mulet, Roberto · 2024
Full title: Sodium acetate increases the productivity of HEK293 cells expressing the ECD-Her1 protein in batch cultures: experimental results and metabolic flux analysis
Authors: Pérez-Fernández, Bárbara Ariane, Calzadilla, Lisandra, Bena, Chiara Enrico, Giudice, Marco Del, Bosia, Carla, Boggiano-Ayo, Tammy, Mulet, Roberto
Changes in the Intestine Microbial, Digestive, and Immune-Related Genes of Litopenaeus vannamei in Response to Dietary Probiotic Clostridium butyricum Supplementation
Full title: Changes in the Intestine Microbial, Digestive, and Immune-Related Genes of Litopenaeus vannamei in Response to Dietary Probiotic Clostridium butyricum Supplementation
Dietary Aroclor 1254-Induced Toxicity on Antioxidant Capacity, Immunity and Energy Metabolism in Chinese Mitten Crab Eriocheir sinensis: Amelioration by Vitamin A.
Full title: Dietary Aroclor 1254-Induced Toxicity on Antioxidant Capacity, Immunity and Energy Metabolism in Chinese Mitten Crab Eriocheir sinensis: Amelioration by Vitamin A.
Effects of Dietary Inclusion of Shrimp Paste on Growth Performance, Digestive Enzymes Activities, Antioxidant and Immunological Status and Intestinal Morphology of Hybrid Snakehead (Channa maculata ♀ × Channa argus ♂).
Full title: Effects of Dietary Inclusion of Shrimp Paste on Growth Performance, Digestive Enzymes Activities, Antioxidant and Immunological Status and Intestinal Morphology of Hybrid Snakehead (Channa maculata ♀ × Channa argus ♂).
Comparative study on the effects of crystalline L-methionine and methionine hydroxy analogue calcium supplementations in the diet of juvenile Pacific white shrimp (Litopenaeus vannamei)
Full title: Comparative study on the effects of crystalline L-methionine and methionine hydroxy analogue calcium supplementations in the diet of juvenile Pacific white shrimp (Litopenaeus vannamei)
Dietary Enteromorpha Polysaccharides Supplementation Improves Breast Muscle Yield and Is Associated With Modification of mRNA Transcriptome in Broiler Chickens.
Full title: Dietary Enteromorpha Polysaccharides Supplementation Improves Breast Muscle Yield and Is Associated With Modification of mRNA Transcriptome in Broiler Chickens.
Bacillus subtilis Produces Amino Acids to Stimulate Protein Synthesis in Ruminal Tissue Explants via the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta–Serine/Threonine Kinase–Mammalian Target of Rapamycin Complex 1 Pathway
Qiuju Wang, Yulong Ren, Yizhe Cui, Bingnan Gao, Hao Zhang, Q. Jiang, J. Loor, Z. Deng, Chuang Xu · 2022
Full title: Bacillus subtilis Produces Amino Acids to Stimulate Protein Synthesis in Ruminal Tissue Explants via the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta–Serine/Threonine Kinase–Mammalian Target of Rapamycin Complex 1 Pathway
Authors: Qiuju Wang, Yulong Ren, Yizhe Cui, Bingnan Gao, Hao Zhang, Q. Jiang, J. Loor, Z. Deng, Chuang Xu
Varying the ratio of Lys: Met through enhancing methionine supplementation improved milk secretion ability through regulating the mRNA expression in bovine mammary epithelial cells under heat stress
Lin Fu, Yinjie You, Yu Zeng, Qifan Ran, Yan Zhou, Rui Long, Heng Yang, Juncai Chen, Juan J. Loor, Gaofu Wang, Li Zhang, Xianwen Dong · 2024
Full title: Varying the ratio of Lys: Met through enhancing methionine supplementation improved milk secretion ability through regulating the mRNA expression in bovine mammary epithelial cells under heat stress
Authors: Lin Fu, Yinjie You, Yu Zeng, Qifan Ran, Yan Zhou, Rui Long, Heng Yang, Juncai Chen, Juan J. Loor, Gaofu Wang, Li Zhang, Xianwen Dong
High-Level Production of scFv-Fc Antibody Using an Artificial Promoter System with Transcriptional Positive Feedback Loop of Transactivator in CHO Cells
Full title: High-Level Production of scFv-Fc Antibody Using an Artificial Promoter System with Transcriptional Positive Feedback Loop of Transactivator in CHO Cells
Dynamics of Amino Acid Metabolism, Gene Expression, and Circulomics in a Recombinant Chinese Hamster Ovary Cell Line Adapted to Moderate and High Levels of Extracellular Lactate
Chitwood, Dylan G., Uy, Lisa, Fu, Wanfang, Klaubert, Stephanie R., Harcum, Sarah W., Saski, Christopher · 2023
Full title: Dynamics of Amino Acid Metabolism, Gene Expression, and Circulomics in a Recombinant Chinese Hamster Ovary Cell Line Adapted to Moderate and High Levels of Extracellular Lactate
Authors: Chitwood, Dylan G., Uy, Lisa, Fu, Wanfang, Klaubert, Stephanie R., Harcum, Sarah W., Saski, Christopher
Identification of Cell Culture Factors Influencing Afucosylation Levels in Monoclonal Antibodies by Partial Least-Squares Regression and Variable Importance Metrics
Rish, Adam J., Huang, Zhuangrong, Siddiquee, Khandaker, Xu, Jianlin, Anderson, Carl A., Borys, Michael, Khetan, Anurag · 2023
Full title: Identification of Cell Culture Factors Influencing Afucosylation Levels in Monoclonal Antibodies by Partial Least-Squares Regression and Variable Importance Metrics
Authors: Rish, Adam J., Huang, Zhuangrong, Siddiquee, Khandaker, Xu, Jianlin, Anderson, Carl A., Borys, Michael, Khetan, Anurag
Full title: Enhanced Production of Anti-PD1 Antibody in CHO Cells through Transient Co-Transfection with Anti-Apoptotic Gene Bcl-xL Combined with Rapamycin
Full title: Effect of Sialic Acid on Mammalian Cell Culture and Protein Expression: A Potential Productivity Enhancer for Biopharmaceutical Cell Culture Processes
Optimizing the Production of gp145, an HIV-1 Envelope Glycoprotein Vaccine Candidate and Its Encapsulation in Guanosine Microparticles
Akamine, Pearl, González‐Feliciano, José A., Almodóvar, Ruth, Morell, Gloriner, Sandoval, Javier, Capó-Vélez, Coral M., Delgado‐Vélez, Manuel, Prieto-Costas, Luis A., Madera, Bismark, Eichinger, Daniel, Pino, Ignacio, Rivera, José H., Ortiz-Ubarri, José, Rivera, José M., Baerga‐Ortiz, Abel, Lasalde‐Dominicci, José A. · 2023
Full title: Optimizing the Production of gp145, an HIV-1 Envelope Glycoprotein Vaccine Candidate and Its Encapsulation in Guanosine Microparticles
Authors: Akamine, Pearl, González‐Feliciano, José A., Almodóvar, Ruth, Morell, Gloriner, Sandoval, Javier, Capó-Vélez, Coral M., Delgado‐Vélez, Manuel, Prieto-Costas, Luis A., Madera, Bismark, Eichinger, Daniel, Pino, Ignacio, Rivera, José H., Ortiz-Ubarri, José, Rivera, José M., Baerga‐Ortiz, Abel, Lasalde‐Dominicci, José A.
Is the development of low-cost media one of the greatest challenges to produce cultivated meat on an industrial scale?
Soccol, Carlos Ricardo, Karp, Susan Grace, Letti, Luiz Alberto Júnior, Biagini, Giuliana, Balla, Gabriel, Boligon, Ana Paula, Candelário, João Pedro Mânica, Faria, Thiago Feliciano, Mattos, Patrícia Beatriz Gruening de, Piazenski, Igor Negreiros, Raymundo, L.C., Valeixo, Daniel Augusto Ribeiro Rolim, Thomaz‐Soccol, Vanete · 2022
Full title: Is the development of low-cost media one of the greatest challenges to produce cultivated meat on an industrial scale?
Authors: Soccol, Carlos Ricardo, Karp, Susan Grace, Letti, Luiz Alberto Júnior, Biagini, Giuliana, Balla, Gabriel, Boligon, Ana Paula, Candelário, João Pedro Mânica, Faria, Thiago Feliciano, Mattos, Patrícia Beatriz Gruening de, Piazenski, Igor Negreiros, Raymundo, L.C., Valeixo, Daniel Augusto Ribeiro Rolim, Thomaz‐Soccol, Vanete
Effects of dandelion (Taraxacum sp.,) supplements on lactation performance, antioxidative activity, and plasma metabolome in primiparous dairy cows
Yan Li, Jie Mei, Jiaqi Wang, Hongyun Liu · 2022
Full title: Effects of dandelion (Taraxacum sp.,) supplements on lactation performance, antioxidative activity, and plasma metabolome in primiparous dairy cows
Effect of different levels of protein concentrates supplementation on the growth performance, plasma amino acids profile and mTOR cascade genes expression in early-weaned yak calves.
Peng, Q H, Khan, N A, Xue, B, Yan, T H, Wang, Z S · 2018
Full title: Effect of different levels of protein concentrates supplementation on the growth performance, plasma amino acids profile and mTOR cascade genes expression in early-weaned yak calves.
Authors: Peng, Q H, Khan, N A, Xue, B, Yan, T H, Wang, Z S
Milk yield and immune response of periparturient and early lactation friesian cows fed diets supplemented with a high level of amino-acid chelated chromium
S. Terramoccia, S. Bartocci, E. Lillini · 2005
Full title: Milk yield and immune response of periparturient and early lactation friesian cows fed diets supplemented with a high level of amino-acid chelated chromium
Use of δ-Aminolevulinic Acid in Swine Diet: Effect on Growth Performance, Behavioral Characteristics and Hematological/Immune Status in Nursery Pigs
R. D. Mateo, J. Morrow, J. Dailey, F. Ji, S. Kim · 2005
Full title: Use of δ-Aminolevulinic Acid in Swine Diet: Effect on Growth Performance, Behavioral Characteristics and Hematological/Immune Status in Nursery Pigs
Authors: R. D. Mateo, J. Morrow, J. Dailey, F. Ji, S. Kim
Effect of Essential and Nonessential Amino Acids in North Carolina State University (NCSU)-23 Medium on Development of Porcine In vitro Fertilized Embryos
M. A. Hashem, D. Bhandari, M. Hossein, Jeong Yeon Woo, Kim Sue, Kim Ji-Hye, Koo Ok-Jae, Park Seon Mi, Lee Eu Gine, Park Sun Woo, S. Kang, Byeong-chun Lee · 2007
Full title: Effect of Essential and Nonessential Amino Acids in North Carolina State University (NCSU)-23 Medium on Development of Porcine In vitro Fertilized Embryos
Authors: M. A. Hashem, D. Bhandari, M. Hossein, Jeong Yeon Woo, Kim Sue, Kim Ji-Hye, Koo Ok-Jae, Park Seon Mi, Lee Eu Gine, Park Sun Woo, S. Kang, Byeong-chun Lee
Effects of Dietary Supplementation of Barodon, an Anionic Alkali Mineral Complex, on Growth Performance, Feed Utilization, Innate Immunity, Goblet Cell and Digestibility in Olive Flounder (Paralichthys olivaceus).
Full title: Effects of Dietary Supplementation of Barodon, an Anionic Alkali Mineral Complex, on Growth Performance, Feed Utilization, Innate Immunity, Goblet Cell and Digestibility in Olive Flounder (Paralichthys olivaceus).
Effects of Peptone Supplementation in Different Culture Media on Growth, Metabolic Pathway and Productivity of CHO DG44 Cells; a New Insight into Amino Acid Profiles.
Full title: Effects of Peptone Supplementation in Different Culture Media on Growth, Metabolic Pathway and Productivity of CHO DG44 Cells; a New Insight into Amino Acid Profiles.
Marked variations in gut microbiota and some innate immune responses of fresh water crayfish, marron (Cherax cainii, Austin 2002) fed dietary supplementation of Clostridium butyricum.
Full title: Marked variations in gut microbiota and some innate immune responses of fresh water crayfish, marron (Cherax cainii, Austin 2002) fed dietary supplementation of Clostridium butyricum.
A genome-scale metabolic network model synergizes with statistical learning to predict amino acid concentrations in Chinese Hamster Ovary cell cultures
Song-Min Schinn, Carly Morrison, Wei Wei, Lin Zhang, Nathan E. Lewis · 2020
Full title: A genome-scale metabolic network model synergizes with statistical learning to predict amino acid concentrations in Chinese Hamster Ovary cell cultures
Authors: Song-Min Schinn, Carly Morrison, Wei Wei, Lin Zhang, Nathan E. Lewis
Immunogenic and Protective Properties of Recombinant Hemagglutinin of Influenza A (H5N8) Virus
N. Rudometova, A. A. Fando, L. A. Kisakova, D. N. Kisakov, M. B. Borgoyakova, V. R. Litvinova, V. A. Yakovlev, E. V. Tigeeva, Danil I. Vahitov, S. V. Sharabrin, D. Shcherbakov, V. I. Evseenko, K. I. Ivanova, A. Gudymo, T. Ilyicheva, V. Marchenko, A. Ilyichev, A. P. Rudometov, L. Karpenko · 2024
Full title: Immunogenic and Protective Properties of Recombinant Hemagglutinin of Influenza A (H5N8) Virus
Authors: N. Rudometova, A. A. Fando, L. A. Kisakova, D. N. Kisakov, M. B. Borgoyakova, V. R. Litvinova, V. A. Yakovlev, E. V. Tigeeva, Danil I. Vahitov, S. V. Sharabrin, D. Shcherbakov, V. I. Evseenko, K. I. Ivanova, A. Gudymo, T. Ilyicheva, V. Marchenko, A. Ilyichev, A. P. Rudometov, L. Karpenko
Influência do butirato de sódio, da cicloheximida e do cloreto de manganês na produtividade, glicosilação e propriedades biológicas da tireotrofina humana derivada de CHO
Ribela, Maria Teresa de Carvalho Pinto · 2014
Full title: Influência do butirato de sódio, da cicloheximida e do cloreto de manganês na produtividade, glicosilação e propriedades biológicas da tireotrofina humana derivada de CHO
Effects of human growth factors TGF-β1 and PDGF-BB stable heterologous expression and exogenous addition over the growth performance of CHO and HEK cell lines in adherent culture
Tonso, Aldo · 2022
Full title: Effects of human growth factors TGF-β1 and PDGF-BB stable heterologous expression and exogenous addition over the growth performance of CHO and HEK cell lines in adherent culture
The Effect of Dietary Nucleotide Supplementation on Growth and Feed Efficiency of Rainbow Trout (Oncorhynchus mykiss) Fed Fish Meal-Free and Animal Protein-Free Diets
Liu, Bing · 2016
Full title: The Effect of Dietary Nucleotide Supplementation on Growth and Feed Efficiency of Rainbow Trout (Oncorhynchus mykiss) Fed Fish Meal-Free and Animal Protein-Free Diets
Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe et al. · 2016
Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
Authors: López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe; Carrillo-Cocom, Leydi Maribel; Rocha-Pizaña, María del Refugio; Alvarez, Mario Moises
Strategies to improve protein production of Chinese hamster ovary cell lines and genome annotation under the guidance of high throughput omics technology
Li, Shangzhong · 2019
Full title: Strategies to improve protein production of Chinese hamster ovary cell lines and genome annotation under the guidance of high throughput omics technology
An investigation of the effects of additives on Chinese Hamster ovary cells : the optimization of a quantitative technique for mass screening /
Younger, Angela Camille · 1999
Full title: An investigation of the effects of additives on Chinese Hamster ovary cells : the optimization of a quantitative technique for mass screening /
Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions
Backliwal, G; Hildinger, M; Chenuet, S et al. · 2009
Full title: Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions
Authors: Backliwal, G; Hildinger, M; Chenuet, S; Wulhfard, S; De Jesus, M; Wurm, FM
Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand
Chua, Gek Kee · 2011
Full title: Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand
Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium
Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Òdena, Andreu et al. · 2023
Full title: Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium
Authors: Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Òdena, Andreu; Karottki, Karen Julie la Cour; Kim, Che Lin; Hefzi, Hooman; Lee, Gyun Min; Faustrup Kildegaard, Helene; Nielsen, Lars K.; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lewis, Nathan E.
Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing
Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP] et al. · 2019
Full title: Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing
Authors: Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP]; Deffune, Elenice; Suazo, Cláudio Alberto Torres
Solving the foetal bovine serum problem for cultivated meat – investigation of methods, adult bovine blood products, and first isolation and cultivation of cervine muscle cells in a defined system
Steinmetz, Kai · 2025
Full title: Solving the foetal bovine serum problem for cultivated meat – investigation of methods, adult bovine blood products, and first isolation and cultivation of cervine muscle cells in a defined system
Sobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes
Bulté Ocaña, Dubhe Beatriz · 2021
Full title: Sobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes
Full title: Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms
Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium
Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Òdena, Andreu et al. · 2023
Full title: Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium
Authors: Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Òdena, Andreu; Karottki, Karen Julie la Cour; Kim, Che Lin; Hefzi, Hooman; Lee, Gyun Min; Faustrup Kildegaard, Helene; Nielsen, Lars K.; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lewis, Nathan E.
Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing
Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP] et al. · 2019
Full title: Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing
Authors: Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP]; Deffune, Elenice; Suazo, Cláudio Alberto Torres
Full title: Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.
Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe et al. · 2016
Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
Authors: López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe; Carrillo-Cocom, Leydi Maribel; Rocha-Pizaña, María del Refugio; Alvarez, Mario Moises
Influência do butirato de sódio, da cicloheximida e do cloreto de manganês na produtividade, glicosilação e propriedades biológicas da tireotrofina humana derivada de CHO
Ribela, Maria Teresa de Carvalho Pinto · 2014
Full title: Influência do butirato de sódio, da cicloheximida e do cloreto de manganês na produtividade, glicosilação e propriedades biológicas da tireotrofina humana derivada de CHO
Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions
Backliwal, G; Hildinger, M; Chenuet, S et al. · 2009
Full title: Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions
Authors: Backliwal, G; Hildinger, M; Chenuet, S; Wulhfard, S; De Jesus, M; Wurm, FM
Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand
Chua, Gek Kee · 2011
Full title: Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand
Effects of human growth factors TGF-β1 and PDGF-BB stable heterologous expression and exogenous addition over the growth performance of CHO and HEK cell lines in adherent culture
Tonso, Aldo · 2022
Full title: Effects of human growth factors TGF-β1 and PDGF-BB stable heterologous expression and exogenous addition over the growth performance of CHO and HEK cell lines in adherent culture
Sobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes
Bulté Ocaña, Dubhe Beatriz · 2021
Full title: Sobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes
Solving the foetal bovine serum problem for cultivated meat – investigation of methods, adult bovine blood products, and first isolation and cultivation of cervine muscle cells in a defined system
Steinmetz, Kai · 2025
Full title: Solving the foetal bovine serum problem for cultivated meat – investigation of methods, adult bovine blood products, and first isolation and cultivation of cervine muscle cells in a defined system
Identification of cellular changes associated with increased production of human follicle stimulating hormone in a recombinant Chinese hamster ovary cell line
Misztal, David Richard · 2008
Full title: Identification of cellular changes associated with increased production of human follicle stimulating hormone in a recombinant Chinese hamster ovary cell line
Strategies to improve protein production of Chinese hamster ovary cell lines and genome annotation under the guidance of high throughput omics technology
Li, Shangzhong · 2019
Full title: Strategies to improve protein production of Chinese hamster ovary cell lines and genome annotation under the guidance of high throughput omics technology
An investigation of the effects of additives on Chinese Hamster ovary cells : the optimization of a quantitative technique for mass screening /
Younger, Angela Camille · 1999
Full title: An investigation of the effects of additives on Chinese Hamster ovary cells : the optimization of a quantitative technique for mass screening /