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Scale Down Model Qualification Criteria For Mammal

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Paper The role of Raman spectroscopy in biopharmaceuticals from development to manufacturing
Esmonde‐White, Karen A.; Cuellar, Maryann; Lewis, Ian R. · 2021 · Analytical and Bioanalytical Chemistry · DOI
Full title: The role of Raman spectroscopy in biopharmaceuticals from development to manufacturing
Authors: Esmonde‐White, Karen A.; Cuellar, Maryann; Lewis, Ian R.
Year: 2021
Venue: Analytical and Bioanalytical Chemistry
Paper Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors
Metze, Sabrina; Ruhl, S. F.; Greller, Gerhard et al. · 2019 · Bioprocess and Biosystems Engineering · DOI
Full title: Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors
Authors: Metze, Sabrina; Ruhl, S. F.; Greller, Gerhard; Grimm, C.; Scholz, Judith
Year: 2019
Venue: Bioprocess and Biosystems Engineering
Paper Automated Conditional Screening of Escherichia Coli Knockout Mutants in Parallel Adaptive Fed-Batch Cultivations
Hans, Sebastian; Haby, Benjamin; Krausch, Niels et al. · 2020 · Preprints.org · DOI
Full title: Automated Conditional Screening of Escherichia Coli Knockout Mutants in Parallel Adaptive Fed-Batch Cultivations
Authors: Hans, Sebastian; Haby, Benjamin; Krausch, Niels; Barz, Tilman; Neubauer, Peter; Bournazou, Mariano Nicolás Cruz
Year: 2020
Venue: Preprints.org
Paper Glucose-Limited Fed-Batch Cultivation Strategy to Mimic Large-Scale Effects in Escherichia coli Linked to Accumulation of Non-Canonical Branched-Chain Amino Acids by Combination of Pyruvate Pulses and Dissolved Oxygen Limitation.
García, Ángel Córcoles; Hauptmann, Peter; Neubauer, Peter · 2021 · Microorganisms · DOI
Full title: Glucose-Limited Fed-Batch Cultivation Strategy to Mimic Large-Scale Effects in Escherichia coli Linked to Accumulation of Non-Canonical Branched-Chain Amino Acids by Combination of Pyruvate Pulses and Dissolved Oxygen Limitation.
Authors: García, Ángel Córcoles; Hauptmann, Peter; Neubauer, Peter
Year: 2021
Venue: Microorganisms
Paper Методические подходы к валидации технологических процессов получения терапевтических рекомбинатных белков на основе концепции «Quality by Design»
Н. В. Стратонова; Александр Сергеевич Лисов; Алексей Николаевич Морозов et al. · 2018 · Biological Products Prevention Diagnosis Treatment · DOI
Full title: Методические подходы к валидации технологических процессов получения терапевтических рекомбинатных белков на основе концепции «Quality by Design»
Authors: Н. В. Стратонова; Александр Сергеевич Лисов; Алексей Николаевич Морозов; Д. В. Тюпа; Р. А. Хамитов
Year: 2018
Venue: Biological Products Prevention Diagnosis Treatment
Paper Optimization of an Industrial Aerobic Bioreactor Using Combined CFD, Scale-Down, and Experimental Techniques
Esmaeilnejad-Ahranjani, Parvaneh; Noofeli, Mojtaba; Faramarzi, Ardeshir · 2022 · SHILAP Revista de lepidopterología · DOI
Full title: Optimization of an Industrial Aerobic Bioreactor Using Combined CFD, Scale-Down, and Experimental Techniques
Authors: Esmaeilnejad-Ahranjani, Parvaneh; Noofeli, Mojtaba; Faramarzi, Ardeshir
Year: 2022
Venue: SHILAP Revista de lepidopterología
Paper Cell clone selection—impact of operation modes and medium exchange strategies on clone ranking
Dorn, Marie; Ferng, Christine; Klottrup‐Rees, Kerensa et al. · 2025 · Frontiers in Bioengineering and Biotechnology · DOI
Full title: Cell clone selection—impact of operation modes and medium exchange strategies on clone ranking
Authors: Dorn, Marie; Ferng, Christine; Klottrup‐Rees, Kerensa; Lee, Kenneth; Micheletti, Martina
Year: 2025
Venue: Frontiers in Bioengineering and Biotechnology
Paper CFD supported scale up of perfusion bioreactors in biopharma
M. Kuschel; J. Wutz; Mustafa Salli et al. · 2023 · Frontiers in Chemical Engineering · DOI
Full title: CFD supported scale up of perfusion bioreactors in biopharma
Authors: M. Kuschel; J. Wutz; Mustafa Salli; D. Monteil; T. Wucherpfennig
Year: 2023
Venue: Frontiers in Chemical Engineering
Paper Scalable CAR-T production in a 2-litre perfusion stirred-tank bioreactor with automated harvesting and scale-down model characterisation.
Springuel, Pierre; Silva Couto, Pedro; Stibbs, Dale J et al. · 2025 · Frontiers in bioengineering and biotechnology · DOI
Full title: Scalable CAR-T production in a 2-litre perfusion stirred-tank bioreactor with automated harvesting and scale-down model characterisation.
Authors: Springuel, Pierre; Silva Couto, Pedro; Stibbs, Dale J; Szelwicki, Michal; Frangleton, Amanda; Schmidberger, Timo; George, Ajith; Slingsby, Fern; Bevan, Nicola; Ahmad, Asma; Legmann, Rachel; Dianat, Noushin; Ladi, Rukmini; Hengst, Julia; Rafiq, Qasim A
Year: 2025
Venue: Frontiers in bioengineering and biotechnology
Paper Small-Scale Fluidized Bed Bioreactor for Long-Term Dynamic Culture of 3D Cell Constructs and in vitro Testing.
Mendonça da Silva, Joana; Erro, Eloy; Awan, Maooz et al. · 2020 · Frontiers in bioengineering and biotechnology · DOI
Full title: Small-Scale Fluidized Bed Bioreactor for Long-Term Dynamic Culture of 3D Cell Constructs and in vitro Testing.
Authors: Mendonça da Silva, Joana; Erro, Eloy; Awan, Maooz; Chalmers, Sherri-Ann; Fuller, Barry; Selden, Clare
Year: 2020
Venue: Frontiers in bioengineering and biotechnology
Paper Growth and eGFP Production of CHO-K1 Suspension Cells Cultivated From Single Cell to Laboratory Scale
Schmitz, Julian; Hertel, Oliver; Yermakov, Boris et al. · 2021 · Frontiers in Bioengineering and Biotechnology · DOI
Full title: Growth and eGFP Production of CHO-K1 Suspension Cells Cultivated From Single Cell to Laboratory Scale
Authors: Schmitz, Julian; Hertel, Oliver; Yermakov, Boris; Noll, Thomas; Grünberger, Alexander
Year: 2021
Venue: Frontiers in Bioengineering and Biotechnology
Paper Development of 10 L mass culture system of human induced pluripotent stem cells with intermittent agitation using plastic fluid.
Tokura, Tomohiro; Yamamoto, Riku; Kino-Oka, Masahiro · 2025 · Frontiers in bioengineering and biotechnology · DOI
Full title: Development of 10 L mass culture system of human induced pluripotent stem cells with intermittent agitation using plastic fluid.
Authors: Tokura, Tomohiro; Yamamoto, Riku; Kino-Oka, Masahiro
Year: 2025
Venue: Frontiers in bioengineering and biotechnology
Paper Putting the Spotlight Back on Plant Suspension Cultures
Santos, Rita B.; Abranches, Rita; Fischer, Rainer et al. · 2016 · Frontiers in Plant Science · DOI
Full title: Putting the Spotlight Back on Plant Suspension Cultures
Authors: Santos, Rita B.; Abranches, Rita; Fischer, Rainer; Sack, M.; Holland, Tanja
Year: 2016
Venue: Frontiers in Plant Science
Paper Miniaturization and 3D Printing of Bioreactors: A Technological Mini Review
Achinas, Spyridon; Heins, Jorn‐Ids; Krooneman, Janneke et al. · 2020 · Micromachines · DOI
Full title: Miniaturization and 3D Printing of Bioreactors: A Technological Mini Review
Authors: Achinas, Spyridon; Heins, Jorn‐Ids; Krooneman, Janneke; Euverink, Gerrit Jan Willem
Year: 2020
Venue: Micromachines
Paper Seed Train Optimization in Microcarrier-Based Cell Culture Post In Situ Cell Detachment through Scale-Down Hybrid Modeling
Ebrahimian, Atefeh; Schalk, Mona; Dürkop, Mark et al. · 2024 · Bioengineering · DOI
Full title: Seed Train Optimization in Microcarrier-Based Cell Culture Post In Situ Cell Detachment through Scale-Down Hybrid Modeling
Authors: Ebrahimian, Atefeh; Schalk, Mona; Dürkop, Mark; Maurer, Michael; Bliem, Rudolf; Kühnel, Harald
Year: 2024
Venue: Bioengineering
Paper Monitoring of the Single-Cell Behavior of an Escherichia coli Reporter Strain Producing L-phenylalanine in a Scale-Down Bioreactor by Automated Real-Time Flow Cytometry.
Arulrajah, Prasika; Riessner, Sophi Katharina; Heins, Anna-Lena et al. · 2025 · Biotech (Basel (Switzerland)) · DOI
Full title: Monitoring of the Single-Cell Behavior of an Escherichia coli Reporter Strain Producing L-phenylalanine in a Scale-Down Bioreactor by Automated Real-Time Flow Cytometry.
Authors: Arulrajah, Prasika; Riessner, Sophi Katharina; Heins, Anna-Lena; Weuster-Botz, Dirk
Year: 2025
Venue: Biotech (Basel (Switzerland))
Paper Bioprocess Design Considerations for Cultured Meat Production With a Focus on the Expansion Bioreactor
Allan, Scott J.; Bank, Paul De; Ellis, Marianne J. · 2019 · Frontiers in Sustainable Food Systems · DOI
Full title: Bioprocess Design Considerations for Cultured Meat Production With a Focus on the Expansion Bioreactor
Authors: Allan, Scott J.; Bank, Paul De; Ellis, Marianne J.
Year: 2019
Venue: Frontiers in Sustainable Food Systems
Paper Optimization and Scale-Up of Fermentation Processes Driven by Models
Du, Yuan‐Hang; Wang, Min-Yu; Yang, Linhui et al. · 2022 · Bioengineering · DOI
Full title: Optimization and Scale-Up of Fermentation Processes Driven by Models
Authors: Du, Yuan‐Hang; Wang, Min-Yu; Yang, Linhui; Tong, Lingling; Guo, Dong‐Sheng; Ji, Xiao‐Jun
Year: 2022
Venue: Bioengineering
Paper Automated Conditional Screening of Multiple Escherichia coli Strains in Parallel Adaptive Fed-Batch Cultivations
Hans, Sebastian; Haby, Benjamin; Krausch, Niels et al. · 2020 · Bioengineering · DOI
Full title: Automated Conditional Screening of Multiple Escherichia coli Strains in Parallel Adaptive Fed-Batch Cultivations
Authors: Hans, Sebastian; Haby, Benjamin; Krausch, Niels; Barz, Tilman; Neubauer, Peter; Bournazou, Mariano Nicolás Cruz
Year: 2020
Venue: Bioengineering
Paper Measurement of Oxygen Transfer Rate and Specific Oxygen Uptake Rate of h-iPSC Aggregates in Vertical Wheel Bioreactors to Predict Maximum Cell Density Before Oxygen Limitation
Kim, James; Agbojo, Omokhowa M.; Jung, Sunghoon et al. · 2025 · Bioengineering · DOI
Full title: Measurement of Oxygen Transfer Rate and Specific Oxygen Uptake Rate of h-iPSC Aggregates in Vertical Wheel Bioreactors to Predict Maximum Cell Density Before Oxygen Limitation
Authors: Kim, James; Agbojo, Omokhowa M.; Jung, Sunghoon; Croughan, Matthew S.
Year: 2025
Venue: Bioengineering
Paper Hydrodynamics and Mass Transfer Analysis in BioFlow® Bioreactor Systems
Kordas, Marian; Konopacki, Maciej; Grygorcewicz, Bartłomiej et al. · 2020 · Processes · DOI
Full title: Hydrodynamics and Mass Transfer Analysis in BioFlow® Bioreactor Systems
Authors: Kordas, Marian; Konopacki, Maciej; Grygorcewicz, Bartłomiej; Augustyniak, Adrian; Musik, Daniel; Wójcik, Krzysztof; Jędrzejczak-Silicka, Magdalena; Rakoczy, Rafał
Year: 2020
Venue: Processes
Paper Predicting By-Product Gradients of Baker’s Yeast Production at Industrial Scale: A Practical Simulation Approach
Hajian, Christopher Sarkizi Shams; Haringa, Cees; Noorman, Henk et al. · 2020 · Processes · DOI
Full title: Predicting By-Product Gradients of Baker’s Yeast Production at Industrial Scale: A Practical Simulation Approach
Authors: Hajian, Christopher Sarkizi Shams; Haringa, Cees; Noorman, Henk; Takors, Ralf
Year: 2020
Venue: Processes
Paper Hybrid Approach for Mixing Time Characterization and Scale-Up in Geometrical Nonsimilar Stirred Vessels Equipped with Eccentric Multi-Impeller Systems—An Industrial Perspective
Michael C. Martinetz; F. Kaiser; M. Kellner et al. · 2021 · DOI
Full title: Hybrid Approach for Mixing Time Characterization and Scale-Up in Geometrical Nonsimilar Stirred Vessels Equipped with Eccentric Multi-Impeller Systems—An Industrial Perspective
Authors: Michael C. Martinetz; F. Kaiser; M. Kellner; D. Schlosser; A. Lange; Michaela Brueckner-Pichler; C. Brocard; M. Šoóš
Year: 2021
Paper Monitoring Intracellular Metabolite Dynamics in Saccharomyces cerevisiae during Industrially Relevant Famine Stimuli
Minden, Steven; Aniolek, Maria; Hajian, Christopher Sarkizi Shams et al. · 2022 · Metabolites · DOI
Full title: Monitoring Intracellular Metabolite Dynamics in Saccharomyces cerevisiae during Industrially Relevant Famine Stimuli
Authors: Minden, Steven; Aniolek, Maria; Hajian, Christopher Sarkizi Shams; Teleki, Attila; Zerrer, Tobias; Delvigne, Frank; Gulik, Walter van; Deshmukh, Amit T.; Noorman, Henk; Takors, Ralf
Year: 2022
Venue: Metabolites
Paper Glucose-Limited Fed-Batch Cultivation Strategy to Mimic Large-Scale Effects in Escherichia coli Linked to Accumulation of Non-Canonical Branched-Chain Amino Acids by Combination of Pyruvate Pulses and Dissolved Oxygen Limitation.
García, Ángel Córcoles; Hauptmann, Peter; Neubauer, Peter · 2021 · Microorganisms · DOI
Full title: Glucose-Limited Fed-Batch Cultivation Strategy to Mimic Large-Scale Effects in Escherichia coli Linked to Accumulation of Non-Canonical Branched-Chain Amino Acids by Combination of Pyruvate Pulses and Dissolved Oxygen Limitation.
Authors: García, Ángel Córcoles; Hauptmann, Peter; Neubauer, Peter
Year: 2021
Venue: Microorganisms
Paper Optimization of YF17D-Vectored Zika Vaccine Production by Employing Small-Molecule Viral Sensitizers to Enhance Yields
Sven Göbel; Tilia Zinnecker; I. Jordan et al. · 2025 · Vaccines · DOI
Full title: Optimization of YF17D-Vectored Zika Vaccine Production by Employing Small-Molecule Viral Sensitizers to Enhance Yields
Authors: Sven Göbel; Tilia Zinnecker; I. Jordan; V. Sandig; Andrea Vervoort; Jondavid de Jong; Jean-Simon Diallo; P. Satzer; Manfred Satzer; K. Dallmeier; Udo Reichl; Y. Genzel
Year: 2025
Venue: Vaccines
Paper Accumulation of amino acids deriving from pyruvate in <i>Escherichia coli</i> W3110 during fed-batch cultivation in a two-compartment scale-down bioreactor
Soini, Jaakko; Ukkonen, Kaisa; Neubauer, Peter · 2011 · Advances in Bioscience and Biotechnology · DOI
Full title: Accumulation of amino acids deriving from pyruvate in <i>Escherichia coli</i> W3110 during fed-batch cultivation in a two-compartment scale-down bioreactor
Authors: Soini, Jaakko; Ukkonen, Kaisa; Neubauer, Peter
Year: 2011
Venue: Advances in Bioscience and Biotechnology
Paper Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
Kempf, Henning; Olmer, Ruth; Haase, Alexandra et al. · 2016 · Nature Communications · DOI
Full title: Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
Authors: Kempf, Henning; Olmer, Ruth; Haase, Alexandra; Franke, Annika; Bolesani, Emiliano; Schwanke, Kristin; Robles-Diaz, Diana; Coffee, Michelle; Göhring, Gudrun; Dräger, Gerald; Pötz, Oliver; Joos, Thomas; Martı́nez-Hackert, Erik; Haverich, Axel; Buettner, Falk F. R.; Martin, Ulrich; Zweigerdt, Robert
Year: 2016
Venue: Nature Communications
Paper A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production.
Nicholas J. Mozdzierz; K. Love; K. Lee et al. · 2015 · Lab on a Chip · DOI
Full title: A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production.
Authors: Nicholas J. Mozdzierz; K. Love; K. Lee; Harry L. T. Lee; Kartik Shah; Rajeev J Ram; J. C. Love
Year: 2015
Venue: Lab on a Chip
Paper Microbioreactor for lower cost and faster optimisation of protein production
Parekh, Mayur; ali, abdulaziz; Ali, Zulfiqur et al. · 2020 · The Analyst · DOI
Full title: Microbioreactor for lower cost and faster optimisation of protein production
Authors: Parekh, Mayur; ali, abdulaziz; Ali, Zulfiqur; Bateson, Simon; Abugchem, Fathi; Pybus, Leon P.; Lennon, Christopher
Year: 2020
Venue: The Analyst
Paper Pseudo perfusion of Chinese Hamster Ovary (CHO) cells as a reliable platform for data generation to model and guide continuous perfusion biomanufacturing
Malinov, Nikola G.; Barodiya, Shivam; Ierapetritou, Marianthi et al. · 2025 · DOI
Full title: Pseudo perfusion of Chinese Hamster Ovary (CHO) cells as a reliable platform for data generation to model and guide continuous perfusion biomanufacturing
Authors: Malinov, Nikola G.; Barodiya, Shivam; Ierapetritou, Marianthi; Papoutsakis, Eleftherios T.
Year: 2025
Paper Development and application of a cultivation platform for mammalian suspension cell lines with single-cell resolution (MaSC)
Schmitz, Julian; Täuber, Sarah; Westerwalbesloh, Christoph et al. · 2020 · DOI
Full title: Development and application of a cultivation platform for mammalian suspension cell lines with single-cell resolution (MaSC)
Authors: Schmitz, Julian; Täuber, Sarah; Westerwalbesloh, Christoph; Lieres, Eric von; Noll, Thomas; Grünberger, Alexander
Year: 2020
Paper Microfluidic single-cell scale-down bioreactors: A proof-of-concept for the growth of <i>Corynebacterium glutamicum</i> at oscillating pH values
Täuber, Sarah; Blöbaum, Luisa; Steier, Valentin et al. · 2022 · Biotechnology and Bioengineering · DOI
Full title: Microfluidic single-cell scale-down bioreactors: A proof-of-concept for the growth of <i>Corynebacterium glutamicum</i> at oscillating pH values
Authors: Täuber, Sarah; Blöbaum, Luisa; Steier, Valentin; Oldiges, Marco; Grünberger, Alexander
Year: 2022
Venue: Biotechnology and Bioengineering
Paper Optimal operation of parallel mini-bioreactors in bioprocess development using multi-stage MPC
Krausch, Niels; Kim, Jong Woo; Lucia, Sergio et al. · 2021 · DOI
Full title: Optimal operation of parallel mini-bioreactors in bioprocess development using multi-stage MPC
Authors: Krausch, Niels; Kim, Jong Woo; Lucia, Sergio; Groß, Sebastian; Barz, Tilman; Neubauer, Peter; Bournazou, Mariano Nicolás Cruz
Year: 2021
Paper An automated workflow for enhancing microbial bioprocess optimization on a novel microbioreactor platform
Rohe, Peter; Venkanna, Deepak; Kleine, Britta et al. · 2012 · Microbial Cell Factories · DOI
Full title: An automated workflow for enhancing microbial bioprocess optimization on a novel microbioreactor platform
Authors: Rohe, Peter; Venkanna, Deepak; Kleine, Britta; Freudl, Roland; Oldiges, Marco
Year: 2012
Venue: Microbial Cell Factories
Paper Miniature bioreactors: current practices and future opportunities.
Betts, Jonathan Ian; Baganz, Frank · 2006 · Microbial Cell Factories · DOI
Full title: Miniature bioreactors: current practices and future opportunities.
Authors: Betts, Jonathan Ian; Baganz, Frank
Year: 2006
Venue: Microbial Cell Factories
Paper Bioreactor mixing efficiency modulates the activity of a prpoS::GFP reporter gene in E. coli
F. Delvigne; M. Boxus; S. Ingels et al. · 2009 · Microbial Cell Factories · DOI
Full title: Bioreactor mixing efficiency modulates the activity of a prpoS::GFP reporter gene in E. coli
Authors: F. Delvigne; M. Boxus; S. Ingels; P. Thonart
Year: 2009
Venue: Microbial Cell Factories
Paper High cell density media for Escherichia coli are generally designed for aerobic cultivations - consequences for large-scale bioprocesses and shake flask cultures.
Soini, Jaakko; Ukkonen, Kaisa; Neubauer, Peter · 2008 · Microbial cell factories · DOI
Full title: High cell density media for Escherichia coli are generally designed for aerobic cultivations - consequences for large-scale bioprocesses and shake flask cultures.
Authors: Soini, Jaakko; Ukkonen, Kaisa; Neubauer, Peter
Year: 2008
Venue: Microbial cell factories
Paper Exometabolome analysis reveals hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process
Fu, Zhibiao; Verderame, Thomas D; Leighton, Julie et al. · 2014 · Microbial Cell Factories · DOI
Full title: Exometabolome analysis reveals hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process
Authors: Fu, Zhibiao; Verderame, Thomas D; Leighton, Julie; Sampey, Brante P.; Appelbaum, Edward R.; Patel, Pramatesh S.; Aon, Juan C.
Year: 2014
Venue: Microbial Cell Factories
Paper Developing a scalable model of recombinant protein yield from Pichia pastoris: the influence of culture conditions, biomass and induction regime
Holmes, William J.; Darby, Richard A. J.; Wilks, Martin DB et al. · 2009 · Microbial Cell Factories · DOI
Full title: Developing a scalable model of recombinant protein yield from Pichia pastoris: the influence of culture conditions, biomass and induction regime
Authors: Holmes, William J.; Darby, Richard A. J.; Wilks, Martin DB; Smith, Rodney; Bill, Roslyn M.
Year: 2009
Venue: Microbial Cell Factories
Paper Comparisons of optically monitored small-scale stirred tank vessels to optically controlled disposable bag bioreactors.
Hanson, Michael A; Brorson, Kurt A; Moreira, Antonio R et al. · 2009 · Microbial cell factories · DOI
Full title: Comparisons of optically monitored small-scale stirred tank vessels to optically controlled disposable bag bioreactors.
Authors: Hanson, Michael A; Brorson, Kurt A; Moreira, Antonio R; Rao, Govind
Year: 2009
Venue: Microbial cell factories
Paper Antibody disulfide bond reduction during process development: Insights using a scale-down model process
Julie Ruaudel; M. Bertschinger; Sonia Letestu et al. · 2015 · BMC Proceedings · DOI
Full title: Antibody disulfide bond reduction during process development: Insights using a scale-down model process
Authors: Julie Ruaudel; M. Bertschinger; Sonia Letestu; R. Giovannini; P. Wassmann; P. Moretti
Year: 2015
Venue: BMC Proceedings
Paper Bioprocess Control in Microscale: Scalable Fermentations in Disposable and User-Friendly Microfluidic Systems
Funke, Matthias; Buchenauer, Andreas; Mokwa, W. et al. · 2010 · Microbial Cell Factories · DOI
Full title: Bioprocess Control in Microscale: Scalable Fermentations in Disposable and User-Friendly Microfluidic Systems
Authors: Funke, Matthias; Buchenauer, Andreas; Mokwa, W.; Kluge, Stefanie; Hein, Lea; Müller, Carsten H. G.; Kensy, Frank; Büchs, Jochen
Year: 2010
Venue: Microbial Cell Factories
Paper Validation of a high-throughput fermentation system based on online monitoring of biomass and fluorescence in continuously shaken microtiter plates
Kensy, Frank; Zang, Emerson; Faulhammer, Christian et al. · 2009 · Microbial Cell Factories · DOI
Full title: Validation of a high-throughput fermentation system based on online monitoring of biomass and fluorescence in continuously shaken microtiter plates
Authors: Kensy, Frank; Zang, Emerson; Faulhammer, Christian; Tan, Rung-Kai; Büchs, Jochen
Year: 2009
Venue: Microbial Cell Factories
Paper Development and fine-tuning of a scale down model for process characterization studies of a monoclonal antibody upstream production process.
Harmsen, Mareike; Stofferis, Jimmy; Malphettes, Laetitia · 2011 · BMC proceedings · DOI
Full title: Development and fine-tuning of a scale down model for process characterization studies of a monoclonal antibody upstream production process.
Authors: Harmsen, Mareike; Stofferis, Jimmy; Malphettes, Laetitia
Year: 2011
Venue: BMC proceedings
Paper Escherichia coli metabolism under short-term repetitive substrate dynamics: adaptation and trade-offs
Vasilakou, Eleni; Loosdrecht, Mark C.M. van; Wahl, A. · 2020 · Microbial Cell Factories · DOI
Full title: Escherichia coli metabolism under short-term repetitive substrate dynamics: adaptation and trade-offs
Authors: Vasilakou, Eleni; Loosdrecht, Mark C.M. van; Wahl, A.
Year: 2020
Venue: Microbial Cell Factories
Paper Scale-up from microtiter plate to laboratory fermenter: evaluation by online monitoring techniques of growth and protein expression in Escherichia coli and Hansenula polymorpha fermentations
Kensy, Frank; Engelbrecht, Christoph; Büchs, Jochen · 2009 · Microbial Cell Factories · DOI
Full title: Scale-up from microtiter plate to laboratory fermenter: evaluation by online monitoring techniques of growth and protein expression in Escherichia coli and Hansenula polymorpha fermentations
Authors: Kensy, Frank; Engelbrecht, Christoph; Büchs, Jochen
Year: 2009
Venue: Microbial Cell Factories
Paper How to assess chemically defined media and feeds from 9 suppliers on CHO cells producing mAb
Aurore Polès-Lahille; Margaux Paillet; Aurélie Da Silva et al. · 2013 · BMC Proceedings · DOI
Full title: How to assess chemically defined media and feeds from 9 suppliers on CHO cells producing mAb
Authors: Aurore Polès-Lahille; Margaux Paillet; Aurélie Da Silva; Nora Kadi; E. Basque; Flavien Thuet; D. Balbuena; S. Ribault
Year: 2013
Venue: BMC Proceedings
Paper Technology transfer and scale down model development strategy for biotherapeutics produced in mammalian cells
N. Kochanowski; Laetitia Malphettes · 2013 · BMC Proceedings · DOI
Full title: Technology transfer and scale down model development strategy for biotherapeutics produced in mammalian cells
Authors: N. Kochanowski; Laetitia Malphettes
Year: 2013
Venue: BMC Proceedings
Paper Automation assisted anaerobic phenotyping for metabolic engineering.
Raj, Kaushik; Venayak, Naveen; Diep, Patrick et al. · 2021 · Microbial cell factories · DOI
Full title: Automation assisted anaerobic phenotyping for metabolic engineering.
Authors: Raj, Kaushik; Venayak, Naveen; Diep, Patrick; Golla, Sai Akhil; Yakunin, Alexander F; Mahadevan, Radhakrishnan
Year: 2021
Venue: Microbial cell factories
Paper The way to a design space for an animal cell culture process according to Quality by Design (QbD)
R. Puskeiler; Jan Kreuzmann; Caroline Schuster et al. · 2011 · BMC Proceedings · DOI
Full title: The way to a design space for an animal cell culture process according to Quality by Design (QbD)
Authors: R. Puskeiler; Jan Kreuzmann; Caroline Schuster; K. Didzus; Nicole Bartsch; Christian Hakemeyer; H. Schmidt; Melanie Jacobs; Stefan Wolf
Year: 2011
Venue: BMC Proceedings
Paper Parallel use of shake flask and microtiter plate online measuring devices (RAMOS and BioLector) reduces the number of experiments in laboratory-scale stirred tank bioreactors
Wewetzer, Sandra; Kunze, Martin; Ladner, Tobias et al. · 2015 · Journal of Biological Engineering · DOI
Full title: Parallel use of shake flask and microtiter plate online measuring devices (RAMOS and BioLector) reduces the number of experiments in laboratory-scale stirred tank bioreactors
Authors: Wewetzer, Sandra; Kunze, Martin; Ladner, Tobias; Luchterhand, Bettina; Roth, Simon; Rahmen, Natalie; Kloß, Ramona; Silva, A. Costa e; Regestein, Lars; Büchs, Jochen
Year: 2015
Venue: Journal of Biological Engineering
Paper Microfabricated Modular Scale-Down Device for Regenerative Medicine Process Development
Reichen, Marcel; Macown, Rhys J.; Jaccard, Nicolas et al. · 2012 · PLoS ONE · DOI
Full title: Microfabricated Modular Scale-Down Device for Regenerative Medicine Process Development
Authors: Reichen, Marcel; Macown, Rhys J.; Jaccard, Nicolas; Super, Alexandre; Ruban, Ludmila; Griffin, Lewis D.; Veraitch, Farlan; Szita, Nicolas
Year: 2012
Venue: PLoS ONE
Paper Novel low shear 3D bioreactor for high purity mesenchymal stem cell production
Burns, Andrew; Doris, Corinna; Vehar, Kevin et al. · 2021 · PLoS ONE · DOI
Full title: Novel low shear 3D bioreactor for high purity mesenchymal stem cell production
Authors: Burns, Andrew; Doris, Corinna; Vehar, Kevin; Saxena, Vinit; Bardliving, Cameron; Shamlou, P. Ayazi; Phillips, M. Ian
Year: 2021
Venue: PLoS ONE
Paper Flow Characterization of a Spinner Flask for Induced Pluripotent Stem Cell Culture Application
Ismadi, Mohd‐Zulhilmi; Gupta, Priyanka; Fouras, Andreas et al. · 2014 · PLoS ONE · DOI
Full title: Flow Characterization of a Spinner Flask for Induced Pluripotent Stem Cell Culture Application
Authors: Ismadi, Mohd‐Zulhilmi; Gupta, Priyanka; Fouras, Andreas; Verma, Paul J.; Jadhav, Sameer; Bellare, Jayesh; Hourigan, Kerry
Year: 2014
Venue: PLoS ONE
Paper Scale-down bioreactors-comparative analysis of configurations.
Arulrajah, Prasika; Lievonen, Anni Elina; Subaşı, Dilara et al. · 2025 · Bioprocess and biosystems engineering · DOI
Full title: Scale-down bioreactors-comparative analysis of configurations.
Authors: Arulrajah, Prasika; Lievonen, Anni Elina; Subaşı, Dilara; Pagal, Subhashree; Weuster-Botz, Dirk; Heins, Anna-Lena
Year: 2025
Venue: Bioprocess and biosystems engineering
Paper Bovine myoblast cell production in a microcarriers-based system
Verbruggen, Sanne; Luining, Daan; Essen, Anon van et al. · 2017 · Cytotechnology · DOI
Full title: Bovine myoblast cell production in a microcarriers-based system
Authors: Verbruggen, Sanne; Luining, Daan; Essen, Anon van; Post, Mark J.
Year: 2017
Venue: Cytotechnology
Paper Morphology-driven downscaling of Streptomyces lividans to micro-cultivation
Dissel, Dino van; Wezel, Gilles P. van · 2017 · Antonie van Leeuwenhoek · DOI
Full title: Morphology-driven downscaling of Streptomyces lividans to micro-cultivation
Authors: Dissel, Dino van; Wezel, Gilles P. van
Year: 2017
Venue: Antonie van Leeuwenhoek
Paper Does the BioBLU 0.3f single-use scale to the BioFlo® 320 reuseable bioreactor on a matched volumetric oxygen mass transfer coefficient?
Olughu, Williams; Galbraith, Duncan M.; Paget, Cillian et al. · 2021 · World Journal of Microbiology and Biotechnology · DOI
Full title: Does the BioBLU 0.3f single-use scale to the BioFlo® 320 reuseable bioreactor on a matched volumetric oxygen mass transfer coefficient?
Authors: Olughu, Williams; Galbraith, Duncan M.; Paget, Cillian; Ruscoe, Steve; Smith, Josh; Mason, Alison
Year: 2021
Venue: World Journal of Microbiology and Biotechnology
Paper Indicators for optical oxygen sensors
Quaranta, Michela; Borisov, Sergey M.; Klimant, Ingo · 2012 · Bioanalytical reviews · DOI
Full title: Indicators for optical oxygen sensors
Authors: Quaranta, Michela; Borisov, Sergey M.; Klimant, Ingo
Year: 2012
Venue: Bioanalytical reviews
Paper Process Validation in Manufacturing of Biopharmaceuticals
A. Rathore; G. Sofer · 2012 · DOI
Full title: Process Validation in Manufacturing of Biopharmaceuticals
Authors: A. Rathore; G. Sofer
Year: 2012
Paper Engineering of Scale-Down Bioreactor Setup: Deciphering Metabolic Phenotype of Corynebacterium glutamicum under Simulated Bioreactor Inhomogeneity
M. Limberg; W. Wiechert; M. Oldiges et al. · 2017 · DOI
Full title: Engineering of Scale-Down Bioreactor Setup: Deciphering Metabolic Phenotype of Corynebacterium glutamicum under Simulated Bioreactor Inhomogeneity
Authors: M. Limberg; W. Wiechert; M. Oldiges; L. Blank
Year: 2017
Paper Influence of Microenvironment on Mesenchymal Stem Cell Therapeutic Potency: From Planar Culture to Microcarriers
Tsai, Ang‐Chen; Jeske, Richard; Chen, Xingchi et al. · 2020 · Frontiers in Bioengineering and Biotechnology · DOI
Full title: Influence of Microenvironment on Mesenchymal Stem Cell Therapeutic Potency: From Planar Culture to Microcarriers
Authors: Tsai, Ang‐Chen; Jeske, Richard; Chen, Xingchi; Yuan, Xuegang; Li, Yan
Year: 2020
Venue: Frontiers in Bioengineering and Biotechnology
Paper Modern Sensor Tools and Techniques for Monitoring, Controlling, and Improving Cell Culture Processes
Reyes, Sebastian Juan; Durocher, Yves; Pham, Phuong Lan et al. · 2022 · Processes · DOI
Full title: Modern Sensor Tools and Techniques for Monitoring, Controlling, and Improving Cell Culture Processes
Authors: Reyes, Sebastian Juan; Durocher, Yves; Pham, Phuong Lan; Henry, Olivier
Year: 2022
Venue: Processes
Paper Lentiviral Vector Bioprocessing
Perry, Christopher; Rayat, Andrea · 2021 · Viruses · DOI
Full title: Lentiviral Vector Bioprocessing
Authors: Perry, Christopher; Rayat, Andrea
Year: 2021
Venue: Viruses
Paper The effect of potential large-scale bioreactor environmental heterogeneities during fed-batch culture on the performance of an industrially-relevant GS-CHO cell culture, producing an IgG antibody
Scott, William H. · 2011 · University of Birmingham Institutional Research Archive (University of Birmingham)
Full title: The effect of potential large-scale bioreactor environmental heterogeneities during fed-batch culture on the performance of an industrially-relevant GS-CHO cell culture, producing an IgG antibody
Authors: Scott, William H.
Year: 2011
Venue: University of Birmingham Institutional Research Archive (University of Birmingham)
Paper Two-compartment bioreactor as a scale-down model to study the effect of glucose overflow and anaerobiosis on large-scale recombinant protein production processes
Soini, Jaakko; Pajulampi, Ulla; Sandqvist, Janne et al. · 2006 · Microbial Cell Factories · DOI
Full title: Two-compartment bioreactor as a scale-down model to study the effect of glucose overflow and anaerobiosis on large-scale recombinant protein production processes
Authors: Soini, Jaakko; Pajulampi, Ulla; Sandqvist, Janne; Matzen, Arne; Neubauer, Peter
Year: 2006
Venue: Microbial Cell Factories
Paper Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments
Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald et al. · 2021 · Frontiers in Bioengineering and Biotechnology · DOI
Full title: Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments
Authors: Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald; Sissolak, Bernhard
Year: 2021
Venue: Frontiers in Bioengineering and Biotechnology
Paper Novel oscillatory flow reactors for biotechnological applications
Reis, Nuno M. · 2006 · RepositóriUM (Universidade do Minho)
Full title: Novel oscillatory flow reactors for biotechnological applications
Authors: Reis, Nuno M.
Year: 2006
Venue: RepositóriUM (Universidade do Minho)
Thesis Influence of shear stress by gas aspersion in Baculovirus production by SF9 cells in bioreactor
Tonso, Aldo · 2018 · Universidade de São Paulo – USP Digital Library · DOI
Full title: Influence of shear stress by gas aspersion in Baculovirus production by SF9 cells in bioreactor
Authors: Tonso, Aldo
Year: 2018
Venue: Universidade de São Paulo – USP Digital Library
Thesis Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
Monsalve-Bravo, Gloria M; Garelli, Fabricio; Mozumder, Salatul Islam et al. · 2015 · National University of La Plata – SeDiCI · DOI
Full title: Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
Authors: Monsalve-Bravo, Gloria M; Garelli, Fabricio; Mozumder, Salatul Islam; Alvarez, Hernan; De Battista, Hernán
Year: 2015
Venue: National University of La Plata – SeDiCI
Thesis Enhancing the Functionality of a Microscale Bioreactor System as an Industrial Process Development Tool for Mammalian Perfusion Culture
Sewell, David J; Turner, Richard; Field, Ray et al. · 2019 · University of Cambridge · DOI
Full title: Enhancing the Functionality of a Microscale Bioreactor System as an Industrial Process Development Tool for Mammalian Perfusion Culture
Authors: Sewell, David J; Turner, Richard; Field, Ray; Holmes, William; Pradhan, Rahul; Spencer, Christopher; Oliver, Stephen; Slater, Nigel; Dikicioglu, Duygu
Year: 2019
Venue: University of Cambridge
Thesis Computational Fluid Dynamics Simulations of Single-Use Bioreactors for the Scale-Up of Cell Culture Processes
Kreitmayer, Diana · 2022 · Heidelberg University · DOI
Full title: Computational Fluid Dynamics Simulations of Single-Use Bioreactors for the Scale-Up of Cell Culture Processes
Authors: Kreitmayer, Diana
Year: 2022
Venue: Heidelberg University
Thesis Tools for the development of intensified perfusion processes for mammalian cell culture
Schwarz, Hubert · 2022 · KTH Royal Institute of Technology · DOI
Full title: Tools for the development of intensified perfusion processes for mammalian cell culture
Authors: Schwarz, Hubert
Year: 2022
Venue: KTH Royal Institute of Technology
Thesis A computational framework for predicting CHO cell culture performance in bioreactors
Cárcamo Behrens, Martín. · 2019 · Massachusetts Institute of Technology (MIT) · DOI
Full title: A computational framework for predicting CHO cell culture performance in bioreactors
Authors: Cárcamo Behrens, Martín.
Year: 2019
Venue: Massachusetts Institute of Technology (MIT)
Thesis Model-based Design and Control of Biopharmaceutical Manufacturing Processes
Hong, Moo Sun · 2022 · Massachusetts Institute of Technology (MIT) · DOI
Full title: Model-based Design and Control of Biopharmaceutical Manufacturing Processes
Authors: Hong, Moo Sun
Year: 2022
Venue: Massachusetts Institute of Technology (MIT)
Thesis Improving predictability of cell culture processes during biologics manufacturing scale-up through hybrid modeling
Wolszon, Zoë. · 2020 · Massachusetts Institute of Technology (MIT) · DOI
Full title: Improving predictability of cell culture processes during biologics manufacturing scale-up through hybrid modeling
Authors: Wolszon, Zoë.
Year: 2020
Venue: Massachusetts Institute of Technology (MIT)
Thesis Oxygen transport in animal cell biogreactors with vibrating-plate aerators
Nayar, Gautam · 2007 · Massachusetts Institute of Technology (MIT) · DOI
Full title: Oxygen transport in animal cell biogreactors with vibrating-plate aerators
Authors: Nayar, Gautam
Year: 2007
Venue: Massachusetts Institute of Technology (MIT)
Thesis Micro-bioreactor design for Chinese hamster ovary cells
Goh, Shireen · 2013 · Massachusetts Institute of Technology (MIT) · DOI
Full title: Micro-bioreactor design for Chinese hamster ovary cells
Authors: Goh, Shireen
Year: 2013
Venue: Massachusetts Institute of Technology (MIT)
Thesis High-Throughput Platform Development for Chinese Hamster Ovary (CHO) Cell Culture Performance Enhancement Using Small Molecules.
Kalsi, Devika · 2018 · White Rose eTheses (Leeds, Sheffield, York) · DOI
Full title: High-Throughput Platform Development for Chinese Hamster Ovary (CHO) Cell Culture Performance Enhancement Using Small Molecules.
Authors: Kalsi, Devika
Year: 2018
Venue: White Rose eTheses (Leeds, Sheffield, York)
Thesis Integration of CFD Bioreactor Models with Cell Growth Models for the Scale-Up of Cultivated Meat
Kiviat, Kira Leigh · 2024 · University of California, Davis · DOI
Full title: Integration of CFD Bioreactor Models with Cell Growth Models for the Scale-Up of Cultivated Meat
Authors: Kiviat, Kira Leigh
Year: 2024
Venue: University of California, Davis
Thesis Modeling sparging related death in animal cell bioreactors
Meier, Steven J. (Steven John), 1969- · 2009 · Massachusetts Institute of Technology (MIT) · DOI
Full title: Modeling sparging related death in animal cell bioreactors
Authors: Meier, Steven J. (Steven John), 1969-
Year: 2009
Venue: Massachusetts Institute of Technology (MIT)
Thesis Studies on the characterization of the hydrodynamic environment in sparged animal cell cultures /
Garcia-Briones, Miguel Angel · 1994 · OhioLINK Electronic Theses and Dissertations · DOI
Full title: Studies on the characterization of the hydrodynamic environment in sparged animal cell cultures /
Authors: Garcia-Briones, Miguel Angel
Year: 1994
Venue: OhioLINK Electronic Theses and Dissertations
Thesis Study of Hydrodynamics Due to Turbulent Mixing in Animal Cell Microcarrier Bioreactors /
Venkat, Raghavan V. · 1995 · OhioLINK Electronic Theses and Dissertations · DOI
Full title: Study of Hydrodynamics Due to Turbulent Mixing in Animal Cell Microcarrier Bioreactors /
Authors: Venkat, Raghavan V.
Year: 1995
Venue: OhioLINK Electronic Theses and Dissertations
Thesis Bioreactor processes based on disposable materials for the production of recombinant proteins from mammalian cells
Stettler, Matthieu · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Bioreactor processes based on disposable materials for the production of recombinant proteins from mammalian cells
Authors: Stettler, Matthieu
Year: 2007
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up
Tissot, Stéphanie · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up
Authors: Tissot, Stéphanie
Year: 2011
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis Predictive models for upstream mammalian cell culture development: a review
Yatipanthalawa, BS; Gras, SL · 2023 · University of Melbourne · DOI
Full title: Predictive models for upstream mammalian cell culture development: a review
Authors: Yatipanthalawa, BS; Gras, SL
Year: 2023
Venue: University of Melbourne
Thesis Kontinuierliche Bioprozessführung in miniaturisierten Rührkesselreaktoren
Schmideder, Andreas · 2016 · Technical University of Munich · DOI
Full title: Kontinuierliche Bioprozessführung in miniaturisierten Rührkesselreaktoren
Authors: Schmideder, Andreas
Year: 2016
Venue: Technical University of Munich
Thesis Strömungssimulation als Werkzeug zur Bioreaktorcharakterisierung
Brüning, Stefanie · 2015 · Technical University of Munich · DOI
Full title: Strömungssimulation als Werkzeug zur Bioreaktorcharakterisierung
Authors: Brüning, Stefanie
Year: 2015
Venue: Technical University of Munich
Thesis Scale-down and parallel operation of a riboflavin production process with Bacillus subtilis
Knorr, Bettina · 2007 · Technical University of Munich · DOI
Full title: Scale-down and parallel operation of a riboflavin production process with Bacillus subtilis
Authors: Knorr, Bettina
Year: 2007
Venue: Technical University of Munich
Thesis Reaktionstechnische Optimierung von Parallelreaktoren für kontrollierte Bioprozesse
Kusterer, Andreas · 2008 · Technical University of Munich · DOI
Full title: Reaktionstechnische Optimierung von Parallelreaktoren für kontrollierte Bioprozesse
Authors: Kusterer, Andreas
Year: 2008
Venue: Technical University of Munich
Thesis Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand
Chua, Gek Kee · 2011 · Massey University · DOI
Full title: Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand
Authors: Chua, Gek Kee
Year: 2011
Venue: Massey University
Thesis Miniaturisierte Parallelreaktoren zur Hochdurchsatz-Bioprozessentwicklung
Puskeiler, Robert · 2007 · Technical University of Munich · DOI
Full title: Miniaturisierte Parallelreaktoren zur Hochdurchsatz-Bioprozessentwicklung
Authors: Puskeiler, Robert
Year: 2007
Venue: Technical University of Munich
Thesis Development of a novel bioreactor and systems for suspension cell culture in biopharmaceutical production
Sharma, Rajesh · 2022 · University of Cape Town · DOI
Full title: Development of a novel bioreactor and systems for suspension cell culture in biopharmaceutical production
Authors: Sharma, Rajesh
Year: 2022
Venue: University of Cape Town
Thesis Effects of imperfect mixing in suspended plant and animal cell cultures
Cheung, Caleb Kin Lok · 2006 · UNSW Sydney · DOI
Full title: Effects of imperfect mixing in suspended plant and animal cell cultures
Authors: Cheung, Caleb Kin Lok
Year: 2006
Venue: UNSW Sydney
Thesis Microbubble fermentation of recombinant Pichia pastoris for human serum albumin production
Zhang, Wei · 2014 · Virginia Tech - VTechWorks · DOI
Full title: Microbubble fermentation of recombinant Pichia pastoris for human serum albumin production
Authors: Zhang, Wei
Year: 2014
Venue: Virginia Tech - VTechWorks
Thesis The Biological Impact of High Throughput Continuous Bioprocessing
Sewell, David John · 2020 · University of Cambridge · DOI
Full title: The Biological Impact of High Throughput Continuous Bioprocessing
Authors: Sewell, David John
Year: 2020
Venue: University of Cambridge
Thesis Disseny i desenvolupament de minibioreactors amb instrumentació per a l’optimització de cultius cel· lulars
Soley Astals, Albert · 2011 · Universitat Autònoma de Barcelona (TDX) · DOI
Full title: Disseny i desenvolupament de minibioreactors amb instrumentació per a l’optimització de cultius cel· lulars
Authors: Soley Astals, Albert
Year: 2011
Venue: Universitat Autònoma de Barcelona (TDX)
Thesis A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production
Lee, Kevin S.; Lee, Harry L. T.; Mozdzierz, Nicholas Joseph et al. · 2017 · Massachusetts Institute of Technology (MIT) · DOI
Full title: A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production
Authors: Lee, Kevin S.; Lee, Harry L. T.; Mozdzierz, Nicholas Joseph; Love, Kerry R.; Shah, Kartik A; Ram, Rajeev J; Love, John C
Year: 2017
Venue: Massachusetts Institute of Technology (MIT)
Thesis Preemptive variation reduction in biologic drug substance manufacturing
Güereca Valdivia, Ismael · 2024 · Massachusetts Institute of Technology (MIT) · DOI
Full title: Preemptive variation reduction in biologic drug substance manufacturing
Authors: Güereca Valdivia, Ismael
Year: 2024
Venue: Massachusetts Institute of Technology (MIT)
Thesis Fed-batch microbioreactor platform for scale down and analysis of a plasmid DNA production process
Bower, Diana Morgan; Lee, Kevin Shao-Kwan; Ram, Rajeev J et al. · 2019 · Massachusetts Institute of Technology (MIT) · DOI
Full title: Fed-batch microbioreactor platform for scale down and analysis of a plasmid DNA production process
Authors: Bower, Diana Morgan; Lee, Kevin Shao-Kwan; Ram, Rajeev J; Prather, Kristala L
Year: 2019
Venue: Massachusetts Institute of Technology (MIT)
Thesis Effect of Gas Sparging in Mammalian Cell Bioreactors
Wang, Daniel I.C.; Orton, Dawn · 2005 · Massachusetts Institute of Technology (MIT) · DOI
Full title: Effect of Gas Sparging in Mammalian Cell Bioreactors
Authors: Wang, Daniel I.C.; Orton, Dawn
Year: 2005
Venue: Massachusetts Institute of Technology (MIT)
Thesis Detection of Circulating Tumor Cells in Peripheral Blood and Mixing Time Quantification in Millipore Disposable Bioreactors
Sadeli, Adeline R. · 2011 · OhioLINK Electronic Theses and Dissertations · DOI
Full title: Detection of Circulating Tumor Cells in Peripheral Blood and Mixing Time Quantification in Millipore Disposable Bioreactors
Authors: Sadeli, Adeline R.
Year: 2011
Venue: OhioLINK Electronic Theses and Dissertations
Thesis Helical-Track Bioreactors for Bacterial, Mammalian and Insect Cell Cultures
Tissot, Stéphanie; Michel, Patrik; Douet, Clara et al. · 2013 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Helical-Track Bioreactors for Bacterial, Mammalian and Insect Cell Cultures
Authors: Tissot, Stéphanie; Michel, Patrik; Douet, Clara; Grezet, Sarah; Baldi, Lucia; Hacker, David; Wurm, Florian
Year: 2013
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells
Meuwly, F.; von Stockar, U.; Kadouri, A. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells
Authors: Meuwly, F.; von Stockar, U.; Kadouri, A.
Year: 2006
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis Bioreactor Controls for High Oxygen Uptake Rate (OUR) Demand Processes
Cho, Hyun Woo · 2019 · Johns Hopkins University · DOI
Full title: Bioreactor Controls for High Oxygen Uptake Rate (OUR) Demand Processes
Authors: Cho, Hyun Woo
Year: 2019
Venue: Johns Hopkins University
Thesis Screening for Antibody Reduction at the Clone Selection Stage to Prevent Reduction During Manufacturing
Lakhani, Aliya Abdulaziz · 2019 · Johns Hopkins University · DOI
Full title: Screening for Antibody Reduction at the Clone Selection Stage to Prevent Reduction During Manufacturing
Authors: Lakhani, Aliya Abdulaziz
Year: 2019
Venue: Johns Hopkins University
Thesis Developing a CFD-based axial compartment model for a lab scale bioreactor
Karawan, Blake A. · 2022 · Kansas State University - K-REx · DOI
Full title: Developing a CFD-based axial compartment model for a lab scale bioreactor
Authors: Karawan, Blake A.
Year: 2022
Venue: Kansas State University - K-REx
Thesis Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture
Shariatzadeh, M; Lopes, AG; Glen, KE et al. · 2021 · University of Melbourne · DOI
Full title: Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture
Authors: Shariatzadeh, M; Lopes, AG; Glen, KE; Sinclair, A; Thomas, RJ
Year: 2021
Venue: University of Melbourne
Thesis A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments
Karimi Alavijeh, M; Lee, YY; Gras, SL · 2024 · University of Melbourne · DOI
Full title: A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments
Authors: Karimi Alavijeh, M; Lee, YY; Gras, SL
Year: 2024
Venue: University of Melbourne
Thesis Hydrodynamics considerations in cells systems from ocean flow to perfusion cultivation process
Zhan, Caijuan · 2019 · KTH Royal Institute of Technology · DOI
Full title: Hydrodynamics considerations in cells systems from ocean flow to perfusion cultivation process
Authors: Zhan, Caijuan
Year: 2019
Venue: KTH Royal Institute of Technology
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Metadata only

Paper Bioreactor Scale-Down
L. A. Palomares; O. Ramírez · 2003 · Encyclopedia of Industrial Biotechnology · DOI
Full title: Bioreactor Scale-Down
Authors: L. A. Palomares; O. Ramírez
Year: 2003
Venue: Encyclopedia of Industrial Biotechnology
Paper Bioreactor scale‐down studies of suspended plant cell cultures
Cheung, Caleb K. ‐L.; Leksawasdi, Noppol; Doran, Pauline M. · 2018 · AIChE Journal · DOI
Full title: Bioreactor scale‐down studies of suspended plant cell cultures
Authors: Cheung, Caleb K. ‐L.; Leksawasdi, Noppol; Doran, Pauline M.
Year: 2018
Venue: AIChE Journal
Paper Scale‐Up and Scale‐Down Methodologies for Bioreactors
Neubauer, Peter; Junne, Stefan · 2016 · DOI
Full title: Scale‐Up and Scale‐Down Methodologies for Bioreactors
Authors: Neubauer, Peter; Junne, Stefan
Year: 2016
Paper Perfusion Formats and Their Specific Medium Requirements
Sieck, Jochen B.; Schild, Christian; Hagen, Jörg von · 2017 · DOI
Full title: Perfusion Formats and Their Specific Medium Requirements
Authors: Sieck, Jochen B.; Schild, Christian; Hagen, Jörg von
Year: 2017
Paper Low-cost microbioreactor for high-throughput bioprocessing
Kostov, Yordan; Harms, Peter; Randers‐Eichhorn, Lisa et al. · 2000 · Biotechnology and Bioengineering · DOI
Full title: Low-cost microbioreactor for high-throughput bioprocessing
Authors: Kostov, Yordan; Harms, Peter; Randers‐Eichhorn, Lisa; Rao, Govind
Year: 2000
Venue: Biotechnology and Bioengineering
Paper Scale‐Down: Simulating Large‐Scale Cultures in the Laboratory
Lara, Alvaro R.; Palomares, Laura A.; Ramı́rez, Octavio T. · 2016 · Industrial Biotechnology · DOI
Full title: Scale‐Down: Simulating Large‐Scale Cultures in the Laboratory
Authors: Lara, Alvaro R.; Palomares, Laura A.; Ramı́rez, Octavio T.
Year: 2016
Venue: Industrial Biotechnology
Paper Mixing in the Fermentation and Cell Culture Industries
Amanullah, Ashraf; Buckland, Barry C.; Nienow, Alvin W. · 2003 · DOI
Full title: Mixing in the Fermentation and Cell Culture Industries
Authors: Amanullah, Ashraf; Buckland, Barry C.; Nienow, Alvin W.
Year: 2003
Paper A two-compartment bioreactor system made of commercial parts for bioprocess scale-down studies: impact of oscillations on Bacillus subtilis fed-batch cultivations.
Junne, Stefan; Klingner, Arne; Kabisch, Johannes et al. · 2011 · Biotechnology journal · DOI
Full title: A two-compartment bioreactor system made of commercial parts for bioprocess scale-down studies: impact of oscillations on Bacillus subtilis fed-batch cultivations.
Authors: Junne, Stefan; Klingner, Arne; Kabisch, Johannes; Schweder, Thomas; Neubauer, Peter
Year: 2011
Venue: Biotechnology journal
Paper A Monte‐Carlo approach for the simulation of microbial population dynamics in an heterogeneous scale‐down bioreactor
Doan, Dieu Thi; Kremling, Andreas; Morchain, Jérôme · 2024 · AIChE Journal · DOI
Full title: A Monte‐Carlo approach for the simulation of microbial population dynamics in an heterogeneous scale‐down bioreactor
Authors: Doan, Dieu Thi; Kremling, Andreas; Morchain, Jérôme
Year: 2024
Venue: AIChE Journal
Paper Two scale‐down tools for the optimization of perfusion bioreactors for the manufacture of biopharmaceuticals
Lucas, Ciara; Blackman, Martin; Rayat, Andrea et al. · 2024 · Journal of Advanced Manufacturing and Processing · DOI
Full title: Two scale‐down tools for the optimization of perfusion bioreactors for the manufacture of biopharmaceuticals
Authors: Lucas, Ciara; Blackman, Martin; Rayat, Andrea; Mainwaring, David E.; Micheletti, Martina
Year: 2024
Venue: Journal of Advanced Manufacturing and Processing
Paper Scale-Down Model Development in ambr systems: An Industrial Perspective.
Sandner, Viktor; Pybus, Leon P; McCreath, Graham et al. · 2019 · Biotechnology journal · DOI
Full title: Scale-Down Model Development in ambr systems: An Industrial Perspective.
Authors: Sandner, Viktor; Pybus, Leon P; McCreath, Graham; Glassey, Jarka
Year: 2019
Venue: Biotechnology journal
Paper Challenges in industrial fermentation technology research
Formenti, Luca Riccardo; Nørregaard, Anders; Bolic, Andrijana et al. · 2014 · Biotechnology Journal · DOI
Full title: Challenges in industrial fermentation technology research
Authors: Formenti, Luca Riccardo; Nørregaard, Anders; Bolic, Andrijana; Hernandez, Daniela Quintanilla; Hagemann, Timo; Heins, Anna‐Lena; Larsson, Hilde; Mears, Lisa; Mauricio‐Iglesias, Miguel; Krühne, Ulrich; Gernaey, Krist V.
Year: 2014
Venue: Biotechnology Journal
Paper Scale‐Down Analysis of Fouling in Cell Retention Devices for the Continuous Production of Monoclonal Antibodies
Delphine Tavernier; Timothy Erlandson; A. Rayat · 2025 · Journal of Advanced Manufacturing and Processing · DOI
Full title: Scale‐Down Analysis of Fouling in Cell Retention Devices for the Continuous Production of Monoclonal Antibodies
Authors: Delphine Tavernier; Timothy Erlandson; A. Rayat
Year: 2025
Venue: Journal of Advanced Manufacturing and Processing
Paper Antibody production by a hybridoma cell line at high cell density is limited by two independent mechanisms
Gramer, Michael J.; Britton, Tracey L. · 2002 · Biotechnology and Bioengineering · DOI
Full title: Antibody production by a hybridoma cell line at high cell density is limited by two independent mechanisms
Authors: Gramer, Michael J.; Britton, Tracey L.
Year: 2002
Venue: Biotechnology and Bioengineering
Paper Editorial: Towards faster bioprocess development
Neubauer, Peter · 2011 · Biotechnology Journal · DOI
Full title: Editorial: Towards faster bioprocess development
Authors: Neubauer, Peter
Year: 2011
Venue: Biotechnology Journal
Paper Simulation of dissolved CO<sub>2</sub> gradients in a scale‐down system: A metabolic and transcriptional study of recombinant <i>Escherichia coli</i>
Baez, Antonino; Flores, Noemí; Bolívar, Francisco et al. · 2011 · Biotechnology Journal · DOI
Full title: Simulation of dissolved CO<sub>2</sub> gradients in a scale‐down system: A metabolic and transcriptional study of recombinant <i>Escherichia coli</i>
Authors: Baez, Antonino; Flores, Noemí; Bolívar, Francisco; Ramı́rez, Octavio T.
Year: 2011
Venue: Biotechnology Journal
Paper The impact of pH inhomogeneities on CHO cell physiology and fed-batch process performance - two-compartment scale-down modelling and intracellular pH excursion.
Brunner, Matthias; Braun, Philipp; Doppler, Philipp et al. · 2017 · Biotechnology journal · DOI
Full title: The impact of pH inhomogeneities on CHO cell physiology and fed-batch process performance - two-compartment scale-down modelling and intracellular pH excursion.
Authors: Brunner, Matthias; Braun, Philipp; Doppler, Philipp; Posch, Christoph; Behrens, Dirk; Herwig, Christoph; Fricke, Jens
Year: 2017
Venue: Biotechnology journal
Paper Analysis of particle strain in stirred bioreactors by drop breakage investigations
Maaß, Sebastian; Buscher, Susanne; Hermann, Stephanie et al. · 2011 · Biotechnology Journal · DOI
Full title: Analysis of particle strain in stirred bioreactors by drop breakage investigations
Authors: Maaß, Sebastian; Buscher, Susanne; Hermann, Stephanie; Kraume, Matthias
Year: 2011
Venue: Biotechnology Journal
Paper Computational fluid dynamics simulation improves the design and characterization of a plug‐flow‐type scale‐down reactor for microbial cultivation processes
Mayer, Florian; Cserjan‐Puschmann, Monika; Haslinger, Benedikt et al. · 2022 · Biotechnology Journal · DOI
Full title: Computational fluid dynamics simulation improves the design and characterization of a plug‐flow‐type scale‐down reactor for microbial cultivation processes
Authors: Mayer, Florian; Cserjan‐Puschmann, Monika; Haslinger, Benedikt; Shpylovyi, Anton; Sam, Christian; Šoóš, Miroslav; Hahn, Rainer; Striedner, Gerald
Year: 2022
Venue: Biotechnology Journal
Paper An industrial perspective on bioreactor scale‐down: What we can learn from combined large‐scale bioprocess and model fluid studies
Noorman, Henk · 2011 · Biotechnology Journal · DOI
Full title: An industrial perspective on bioreactor scale‐down: What we can learn from combined large‐scale bioprocess and model fluid studies
Authors: Noorman, Henk
Year: 2011
Venue: Biotechnology Journal
Paper Multivariate Data Analysis Methodology to Solve Data Challenges Related to Scale-Up Model Validation and Missing Data on a Micro-Bioreactor System.
Goldrick, Stephen; Sandner, Viktor; Cheeks, Matthew et al. · 2020 · Biotechnology journal · DOI
Full title: Multivariate Data Analysis Methodology to Solve Data Challenges Related to Scale-Up Model Validation and Missing Data on a Micro-Bioreactor System.
Authors: Goldrick, Stephen; Sandner, Viktor; Cheeks, Matthew; Turner, Richard; Farid, Suzanne S; McCreath, Graham; Glassey, Jarka
Year: 2020
Venue: Biotechnology journal
Paper Culture of <i>Escherichia coli</i> under dissolved oxygen gradients simulated in a two‐compartment scale‐down system: Metabolic response and production of recombinant protein
Sandoval‐Basurto, Edgar A.; Gosset, Guillermo; Bolívar, Francisco et al. · 2004 · Biotechnology and Bioengineering · DOI
Full title: Culture of <i>Escherichia coli</i> under dissolved oxygen gradients simulated in a two‐compartment scale‐down system: Metabolic response and production of recombinant protein
Authors: Sandoval‐Basurto, Edgar A.; Gosset, Guillermo; Bolívar, Francisco; Ramı́rez, Octavio T.
Year: 2004
Venue: Biotechnology and Bioengineering
Paper Scale-down model to simulate spatial pH variations in large-scale bioreactors.
Amanullah, A; McFarlane, C M; Emery, A N et al. · 2001 · Biotechnology and bioengineering · DOI
Full title: Scale-down model to simulate spatial pH variations in large-scale bioreactors.
Authors: Amanullah, A; McFarlane, C M; Emery, A N; Nienow, A W
Year: 2001
Venue: Biotechnology and bioengineering
Paper Equal mixing time enables scale-down and optimization of a CHO cell culture process using a shaken microbioreactor system.
Wiegmann, Vincent; Gardner, Richard A; Spencer, Daniel I R et al. · 2021 · Biotechnology journal · DOI
Full title: Equal mixing time enables scale-down and optimization of a CHO cell culture process using a shaken microbioreactor system.
Authors: Wiegmann, Vincent; Gardner, Richard A; Spencer, Daniel I R; Baganz, Frank
Year: 2021
Venue: Biotechnology journal
Paper Twenty-four well plate miniature bioreactor system as a scale-down model for cell culture process development.
Chen, Aaron; Chitta, Rajesh; Chang, David et al. · 2009 · Biotechnology and bioengineering · DOI
Full title: Twenty-four well plate miniature bioreactor system as a scale-down model for cell culture process development.
Authors: Chen, Aaron; Chitta, Rajesh; Chang, David; Amanullah, Ashraf
Year: 2009
Venue: Biotechnology and bioengineering
Paper Heterogeneous conditions in dissolved oxygen affect N‐glycosylation but not productivity of a monoclonal antibody in hybridoma cultures
Serrato, José A.; Palomares, Laura A.; Meneses‐Acosta, Angélica et al. · 2004 · Biotechnology and Bioengineering · DOI
Full title: Heterogeneous conditions in dissolved oxygen affect N‐glycosylation but not productivity of a monoclonal antibody in hybridoma cultures
Authors: Serrato, José A.; Palomares, Laura A.; Meneses‐Acosta, Angélica; Ramı́rez, Octavio T.
Year: 2004
Venue: Biotechnology and Bioengineering
Paper Engineering <i>Escherichia coli</i> to improve culture performance and reduce formation of by‐products during recombinant protein production under transient intermittent anaerobic conditions
Lara, Alvaro R.; Vázquez-Limón, Consuelo; Gosset, Guillermo et al. · 2006 · Biotechnology and Bioengineering · DOI
Full title: Engineering <i>Escherichia coli</i> to improve culture performance and reduce formation of by‐products during recombinant protein production under transient intermittent anaerobic conditions
Authors: Lara, Alvaro R.; Vázquez-Limón, Consuelo; Gosset, Guillermo; Bolívar, Francisco; López-Munguı́a, Agustı́n; Ramı́rez, Octavio T.
Year: 2006
Venue: Biotechnology and Bioengineering
Paper NS0 cell damage by high gas velocity sparging in protein‐free and cholesterol‐free cultures
Zhu, Ying; Cuenca, James V.; Zhou, Weichang et al. · 2008 · Biotechnology and Bioengineering · DOI
Full title: NS0 cell damage by high gas velocity sparging in protein‐free and cholesterol‐free cultures
Authors: Zhu, Ying; Cuenca, James V.; Zhou, Weichang; Varma, Amit H.
Year: 2008
Venue: Biotechnology and Bioengineering
Paper Scaling strategy for cell and gene therapy bioreactors based on turbulent parameters
Iurashev, Dmytro; Jones, Peter A.; Andreev, Nadejda et al. · 2023 · Biotechnology Journal · DOI
Full title: Scaling strategy for cell and gene therapy bioreactors based on turbulent parameters
Authors: Iurashev, Dmytro; Jones, Peter A.; Andreev, Nadejda; Wang, Yana; Iwata‐Kajihara, Tomoko; Kraus, Barbara; Bort, Juan A. Hernández
Year: 2023
Venue: Biotechnology Journal
Paper Optical sensor enabled rocking T‐flasks as novel upstream bioprocessing tools
Vallejos, José R.; Micheletti, Martina; Brorson, Kurt et al. · 2012 · Biotechnology and Bioengineering · DOI
Full title: Optical sensor enabled rocking T‐flasks as novel upstream bioprocessing tools
Authors: Vallejos, José R.; Micheletti, Martina; Brorson, Kurt; Moreira, Antonio R.; Rao, Govind
Year: 2012
Venue: Biotechnology and Bioengineering
Paper Transcriptional and metabolic response of recombinant <i>Escherichia coli</i> to spatial dissolved oxygen tension gradients simulated in a scale‐down system
Lara, Alvaro R.; Leal, Lidia; Flores, Noemí et al. · 2005 · Biotechnology and Bioengineering · DOI
Full title: Transcriptional and metabolic response of recombinant <i>Escherichia coli</i> to spatial dissolved oxygen tension gradients simulated in a scale‐down system
Authors: Lara, Alvaro R.; Leal, Lidia; Flores, Noemí; Gosset, Guillermo; Bolívar, Francisco; Ramı́rez, Octavio T.
Year: 2005
Venue: Biotechnology and Bioengineering
Paper Oxygen transfer characteristics of miniaturized bioreactor systems
Kirk, Timothy V.; Szita, Nicolas · 2012 · Biotechnology and Bioengineering · DOI
Full title: Oxygen transfer characteristics of miniaturized bioreactor systems
Authors: Kirk, Timothy V.; Szita, Nicolas
Year: 2012
Venue: Biotechnology and Bioengineering
Paper BAK and BAX deletion using zinc‐finger nucleases yields apoptosis‐resistant CHO cells
Cost, Gregory J.; Freyvert, Yevgeniy; Vafiadis, Annamaria et al. · 2009 · Biotechnology and Bioengineering · DOI
Full title: BAK and BAX deletion using zinc‐finger nucleases yields apoptosis‐resistant CHO cells
Authors: Cost, Gregory J.; Freyvert, Yevgeniy; Vafiadis, Annamaria; Santiago, Yolanda; Miller, Jeffrey C.; Rebar, Edward J.; Collingwood, Trevor N.; Snowden, Andrew; Gregory, Philip D.
Year: 2009
Venue: Biotechnology and Bioengineering
Paper Scale-down of the inactivated polio vaccine production process.
Thomassen, Yvonne E; van 't Oever, Aart G; Vinke, Marian et al. · 2013 · Biotechnology and bioengineering · DOI
Full title: Scale-down of the inactivated polio vaccine production process.
Authors: Thomassen, Yvonne E; van 't Oever, Aart G; Vinke, Marian; Spiekstra, Arjen; Wijffels, René H; van der Pol, Leo A; Bakker, Wilfried A M
Year: 2013
Venue: Biotechnology and bioengineering
Paper Proof‐of‐concept of a novel micro‐bioreactor for fast development of industrial bioprocesses
Reis, Nuno M.; Gonçalves, Cristiana; Vicente, António A. et al. · 2006 · Biotechnology and Bioengineering · DOI
Full title: Proof‐of‐concept of a novel micro‐bioreactor for fast development of industrial bioprocesses
Authors: Reis, Nuno M.; Gonçalves, Cristiana; Vicente, António A.; Teixeira, J. A.
Year: 2006
Venue: Biotechnology and Bioengineering
Paper A predictive high-throughput scale-down model of monoclonal antibody production in CHO cells.
Legmann, Rachel; Schreyer, H Brett; Combs, Rodney G et al. · 2009 · Biotechnology and bioengineering · DOI
Full title: A predictive high-throughput scale-down model of monoclonal antibody production in CHO cells.
Authors: Legmann, Rachel; Schreyer, H Brett; Combs, Rodney G; McCormick, Ellen L; Russo, A Peter; Rodgers, Seth T
Year: 2009
Venue: Biotechnology and bioengineering
Paper Software sensor design considering oscillating conditions as present in industrial scale fed‐batch cultivations
Lyubenova, Velislava; Junne, Stefan; Ignatova, Мilena et al. · 2013 · Biotechnology and Bioengineering · DOI
Full title: Software sensor design considering oscillating conditions as present in industrial scale fed‐batch cultivations
Authors: Lyubenova, Velislava; Junne, Stefan; Ignatova, Мilena; Neubauer, Peter
Year: 2013
Venue: Biotechnology and Bioengineering
Paper Metabolic profile of 1,5‐diaminopentane producing Corynebacterium glutamicum under scale‐down conditions: Blueprint for robustness to bioreactor inhomogeneities
Limberg, Michael; Schulte, Julia; Aryani, Tita et al. · 2016 · Biotechnology and Bioengineering · DOI
Full title: Metabolic profile of 1,5‐diaminopentane producing Corynebacterium glutamicum under scale‐down conditions: Blueprint for robustness to bioreactor inhomogeneities
Authors: Limberg, Michael; Schulte, Julia; Aryani, Tita; Mahr, Regina; Baumgart, Meike; Bott, Michael; Wiechert, Wolfgang; Oldiges, Marco
Year: 2016
Venue: Biotechnology and Bioengineering
Paper Physiological effects of pH gradients on Escherichia coli during plasmid DNA production.
Cortés, José T; Flores, Noemí; Bolívar, Francisco et al. · 2016 · Biotechnology and bioengineering · DOI
Full title: Physiological effects of pH gradients on Escherichia coli during plasmid DNA production.
Authors: Cortés, José T; Flores, Noemí; Bolívar, Francisco; Lara, Alvaro R; Ramírez, Octavio T
Year: 2016
Venue: Biotechnology and bioengineering
Paper Application of bioreactor design principles and multivariate analysis for development of cell culture scale down models.
Tescione, Lia; Lambropoulos, James; Paranandi, Madhava Ram et al. · 2015 · Biotechnology and bioengineering · DOI
Full title: Application of bioreactor design principles and multivariate analysis for development of cell culture scale down models.
Authors: Tescione, Lia; Lambropoulos, James; Paranandi, Madhava Ram; Makagiansar, Helena; Ryll, Thomas
Year: 2015
Venue: Biotechnology and bioengineering
Paper Response of Corynebacterium glutamicum exposed to oscillating cultivation conditions in a two- and a novel three-compartment scale-down bioreactor.
Lemoine, Anja; Maya Martίnez-Iturralde, Nina; Spann, Robert et al. · 2015 · Biotechnology and bioengineering · DOI
Full title: Response of Corynebacterium glutamicum exposed to oscillating cultivation conditions in a two- and a novel three-compartment scale-down bioreactor.
Authors: Lemoine, Anja; Maya Martίnez-Iturralde, Nina; Spann, Robert; Neubauer, Peter; Junne, Stefan
Year: 2015
Venue: Biotechnology and bioengineering
Paper Enhancing the functionality of a microscale bioreactor system as an industrial process development tool for mammalian perfusion culture.
Sewell, David J; Turner, Richard; Field, Ray et al. · 2019 · Biotechnology and bioengineering · DOI
Full title: Enhancing the functionality of a microscale bioreactor system as an industrial process development tool for mammalian perfusion culture.
Authors: Sewell, David J; Turner, Richard; Field, Ray; Holmes, William; Pradhan, Rahul; Spencer, Christopher; Oliver, Stephen G; Slater, Nigel Kh; Dikicioglu, Duygu
Year: 2019
Venue: Biotechnology and bioengineering
Paper Power input effects on degeneration in prolonged penicillin chemostat cultures: A systems analysis at flux, residual glucose, metabolite, and transcript levels
Wang, Guan; Wu, Baofeng; Zhao, Junfei et al. · 2017 · Biotechnology and Bioengineering · DOI
Full title: Power input effects on degeneration in prolonged penicillin chemostat cultures: A systems analysis at flux, residual glucose, metabolite, and transcript levels
Authors: Wang, Guan; Wu, Baofeng; Zhao, Junfei; Haringa, Cees; Xia, Jianye; Chu, Ju; Zhuang, Yingping; Zhang, Siliang; Heijnen, Joseph J.; Gulik, Walter van; Deshmukh, Amit T.; Noorman, Henk
Year: 2017
Venue: Biotechnology and Bioengineering
Paper Coupled metabolic‐hydrodynamic modeling enabling rational scale‐up of industrial bioprocesses
Wang, Guan; Haringa, Cees; Tang, Wenjun et al. · 2019 · Biotechnology and Bioengineering · DOI
Full title: Coupled metabolic‐hydrodynamic modeling enabling rational scale‐up of industrial bioprocesses
Authors: Wang, Guan; Haringa, Cees; Tang, Wenjun; Noorman, Henk; Chu, Ju; Zhuang, Yingping; Zhang, Siliang
Year: 2019
Venue: Biotechnology and Bioengineering
Paper Air sparging for prevention of antibody disulfide bond reduction in harvested CHO cell culture fluid.
Mun, Melissa; Khoo, Stefanie; Do Minh, Aline et al. · 2015 · Biotechnology and bioengineering · DOI
Full title: Air sparging for prevention of antibody disulfide bond reduction in harvested CHO cell culture fluid.
Authors: Mun, Melissa; Khoo, Stefanie; Do Minh, Aline; Dvornicky, James; Trexler-Schmidt, Melody; Kao, Yung-Hsiang; Laird, Michael W
Year: 2015
Venue: Biotechnology and bioengineering
Paper Real‐time dissolved carbon dioxide monitoring I: Application of a novel in situ sensor for CO<sub>2</sub> monitoring and control
Chopda, Viki; Holzberg, Timothy; Ge, Xudong et al. · 2019 · Biotechnology and Bioengineering · DOI
Full title: Real‐time dissolved carbon dioxide monitoring I: Application of a novel in situ sensor for CO<sub>2</sub> monitoring and control
Authors: Chopda, Viki; Holzberg, Timothy; Ge, Xudong; Folio, Brandon; Tolosa, Michael; Kostov, Yordan; Tolosa, Leah; Rao, Govind
Year: 2019
Venue: Biotechnology and Bioengineering
Paper Development of a shake tube-based scale-down model for perfusion cultures.
Wolf, Moritz K F; Lorenz, Veronika; Karst, Daniel J et al. · 2018 · Biotechnology and bioengineering · DOI
Full title: Development of a shake tube-based scale-down model for perfusion cultures.
Authors: Wolf, Moritz K F; Lorenz, Veronika; Karst, Daniel J; Souquet, Jonathan; Broly, Hervé; Morbidelli, Massimo
Year: 2018
Venue: Biotechnology and bioengineering
Paper A model‐based framework for parallel scale‐down fed‐batch cultivations in mini‐bioreactors for accelerated phenotyping
Anane, Emmanuel; García, Ángel Córcoles; Haby, Benjamin et al. · 2019 · Biotechnology and Bioengineering · DOI
Full title: A model‐based framework for parallel scale‐down fed‐batch cultivations in mini‐bioreactors for accelerated phenotyping
Authors: Anane, Emmanuel; García, Ángel Córcoles; Haby, Benjamin; Hans, Sebastian; Krausch, Niels; Krewinkel, Manuel; Hauptmann, Peter; Neubauer, Peter; Bournazou, Mariano Nicolás Cruz
Year: 2019
Venue: Biotechnology and Bioengineering
Paper Microfluidic single‐cell scale‐down bioreactors: A proof‐of‐concept for the growth of <i>Corynebacterium glutamicum</i> at oscillating pH values
Täuber, Sarah; Blöbaum, Luisa; Steier, Valentin et al. · 2022 · Biotechnology and Bioengineering · DOI
Full title: Microfluidic single‐cell scale‐down bioreactors: A proof‐of‐concept for the growth of <i>Corynebacterium glutamicum</i> at oscillating pH values
Authors: Täuber, Sarah; Blöbaum, Luisa; Steier, Valentin; Oldiges, Marco; Grünberger, Alexander
Year: 2022
Venue: Biotechnology and Bioengineering
Paper A scaled‐down model for the translation of bacteriophage culture to manufacturing scale
Ali, Junaid; Rafiq, Qasim A.; Ratcliffe, Elizabeth · 2018 · Biotechnology and Bioengineering · DOI
Full title: A scaled‐down model for the translation of bacteriophage culture to manufacturing scale
Authors: Ali, Junaid; Rafiq, Qasim A.; Ratcliffe, Elizabeth
Year: 2018
Venue: Biotechnology and Bioengineering
Paper Understanding the effect of high gas entrance velocity on Chinese hamster ovary (CHO) cell culture performance and its implications on bioreactor scale-up and sparger design.
Chaudhary, Garima; Luo, Robin; George, Meena et al. · 2020 · Biotechnology and bioengineering · DOI
Full title: Understanding the effect of high gas entrance velocity on Chinese hamster ovary (CHO) cell culture performance and its implications on bioreactor scale-up and sparger design.
Authors: Chaudhary, Garima; Luo, Robin; George, Meena; Tescione, Lia; Khetan, Anurag; Lin, Henry
Year: 2020
Venue: Biotechnology and bioengineering
Paper Physiological Response of <i>Penicillium chrysogenum</i> to Mimicked Local and Global Perturbations of Substrate and Dissolved Oxygen Gradients at Industrial‐Scale
Chen, Yining; Haringa, Cees; Wang, Zejian et al. · 2025 · Biotechnology and Bioengineering · DOI
Full title: Physiological Response of <i>Penicillium chrysogenum</i> to Mimicked Local and Global Perturbations of Substrate and Dissolved Oxygen Gradients at Industrial‐Scale
Authors: Chen, Yining; Haringa, Cees; Wang, Zejian; Zhuang, Yingping; Wang, Guan
Year: 2025
Venue: Biotechnology and Bioengineering
Paper Computational fluid dynamics based digital twins of fixed bed bioreactors validate scaling principles for recombinant adeno-associated virus gene therapy manufacturing.
Hill, Michael; White, Colten; Wang, Shaoying et al. · 2024 · Biotechnology and bioengineering · DOI
Full title: Computational fluid dynamics based digital twins of fixed bed bioreactors validate scaling principles for recombinant adeno-associated virus gene therapy manufacturing.
Authors: Hill, Michael; White, Colten; Wang, Shaoying; Thomas, John; DeVincentis, Brian; Singh, Nripen
Year: 2024
Venue: Biotechnology and bioengineering
Paper A CFD model for predicting protein aggregation in low-pH virial inactivation for mAb production.
Xing, Zizhuo; Jin, Weixin; Xu, Xuankuo et al. · 2020 · Biotechnology and bioengineering · DOI
Full title: A CFD model for predicting protein aggregation in low-pH virial inactivation for mAb production.
Authors: Xing, Zizhuo; Jin, Weixin; Xu, Xuankuo; Song, Yuanli; Huang, Chao; Borys, Michael C; Ghose, Sanchayita; Li, Zheng Jian
Year: 2020
Venue: Biotechnology and bioengineering
Paper Mimicking CHO large‐scale effects in the single multicompartment bioreactor: A new approach to access scale‐up behavior
Gaugler, Lena; Hofmann, Sebastian; Schlüter, Michael et al. · 2024 · Biotechnology and Bioengineering · DOI
Full title: Mimicking CHO large‐scale effects in the single multicompartment bioreactor: A new approach to access scale‐up behavior
Authors: Gaugler, Lena; Hofmann, Sebastian; Schlüter, Michael; Takors, Ralf
Year: 2024
Venue: Biotechnology and Bioengineering
Paper Optimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided by design of experiments.
Schwarz, Hubert; Lee, Kevin; Castan, Andreas et al. · 2023 · Biotechnology and bioengineering · DOI
Full title: Optimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided by design of experiments.
Authors: Schwarz, Hubert; Lee, Kevin; Castan, Andreas; Chotteau, Veronique
Year: 2023
Venue: Biotechnology and bioengineering
Paper Perfusion Process Intensification for Lentivirus Production Using a Novel Scale-Down Model.
Klimpel, Maximilian; Pflüger-Müller, Beatrice; Cascallana, Marta Arrizabalaga et al. · 2025 · Biotechnology and bioengineering · DOI
Full title: Perfusion Process Intensification for Lentivirus Production Using a Novel Scale-Down Model.
Authors: Klimpel, Maximilian; Pflüger-Müller, Beatrice; Cascallana, Marta Arrizabalaga; Schwingal, Sarah; Lal, Nikki Indresh; Noll, Thomas; Pirzas, Vicky; Laux, Holger
Year: 2025
Venue: Biotechnology and bioengineering
Paper Bioreactor environment‐sensitive sentinel genes as novel metrics for cell culture scale‐down comparability
Kondragunta, Bhargavi; Joshi, Bharat; Han, Jing et al. · 2012 · Biotechnology Progress · DOI
Full title: Bioreactor environment‐sensitive sentinel genes as novel metrics for cell culture scale‐down comparability
Authors: Kondragunta, Bhargavi; Joshi, Bharat; Han, Jing; Brorson, Kurt; Puri, Raj K.; Moreira, António; Rao, Govind
Year: 2012
Venue: Biotechnology Progress
Paper An industrial perspective on metabolic responses of <i>Penicillium chrysogenum</i> to periodic dissolved oxygen feast‐famine cycles in a scale‐down system
Wang, Xueting; Yang, Qi; Haringa, Cees et al. · 2024 · Biotechnology and Bioengineering · DOI
Full title: An industrial perspective on metabolic responses of <i>Penicillium chrysogenum</i> to periodic dissolved oxygen feast‐famine cycles in a scale‐down system
Authors: Wang, Xueting; Yang, Qi; Haringa, Cees; Wang, Zejian; Chu, Ju; Zhuang, Yingping; Wang, Guan
Year: 2024
Venue: Biotechnology and Bioengineering
Paper Platform development for high‐throughput optimization of perfusion processes: Part I: Implementation of cell bleeds in microwell plates
Marie Dorn; Kerensa Klottrup-Rees; Ken Lee et al. · 2024 · Biotechnology and Bioengineering · DOI
Full title: Platform development for high‐throughput optimization of perfusion processes: Part I: Implementation of cell bleeds in microwell plates
Authors: Marie Dorn; Kerensa Klottrup-Rees; Ken Lee; Martina Micheletti
Year: 2024
Venue: Biotechnology and Bioengineering
Paper Direct and indirect use of GFP whole cell biosensors for the assessment of bioprocess performances: Design of milliliter scale‐down bioreactors
Alison Brognaux; P. Thonart; F. Delvigne et al. · 2013 · Biotechnology progress (Print) · DOI
Full title: Direct and indirect use of GFP whole cell biosensors for the assessment of bioprocess performances: Design of milliliter scale‐down bioreactors
Authors: Alison Brognaux; P. Thonart; F. Delvigne; P. Neubauer; J. Twizere; F. Francis; N. Gorret
Year: 2013
Venue: Biotechnology progress (Print)
Paper Development of a scale down cell culture model using multivariate analysis as a qualification tool.
Tsang, Valerie Liu; Wang, Angela X; Yusuf-Makagiansar, Helena et al. · 2014 · Biotechnology progress · DOI
Full title: Development of a scale down cell culture model using multivariate analysis as a qualification tool.
Authors: Tsang, Valerie Liu; Wang, Angela X; Yusuf-Makagiansar, Helena; Ryll, Thomas
Year: 2014
Venue: Biotechnology progress
Paper Design of growth-dependent biosensors based on destabilized GFP for the detection of physiological behavior of Escherichia coli in heterogeneous bioreactors.
Han, Shanshan; Delvigne, Frank; Brognaux, Alison et al. · 2013 · Biotechnology progress · DOI
Full title: Design of growth-dependent biosensors based on destabilized GFP for the detection of physiological behavior of Escherichia coli in heterogeneous bioreactors.
Authors: Han, Shanshan; Delvigne, Frank; Brognaux, Alison; Charbon, Gitte E; Sørensen, Søren J
Year: 2013
Venue: Biotechnology progress
Paper Establishing a scalable perfusion strategy for the manufacture of CAR ‐T cells in stirred‐tank bioreactors using a quality‐by‐design approach
Hood, Tiffany; Springuel, Pierre; Slingsby, Fern et al. · 2025 · Bioengineering & Translational Medicine · DOI
Full title: Establishing a scalable perfusion strategy for the manufacture of CAR ‐T cells in stirred‐tank bioreactors using a quality‐by‐design approach
Authors: Hood, Tiffany; Springuel, Pierre; Slingsby, Fern; Sandner, Viktor; Geis, W.; Schmidberger, Timo; Bevan, Nicola; Vicard, Quentin; HENGST, J. VAN; Dianat, Noushin; Rafiq, Qasim A.
Year: 2025
Venue: Bioengineering & Translational Medicine
Paper Verification of energy dissipation rate scalability in pilot and production scale bioreactors using computational fluid dynamics
Johnson, C. G.; Natarajan, Venkatesh; Antoniou, Chris · 2014 · Biotechnology Progress · DOI
Full title: Verification of energy dissipation rate scalability in pilot and production scale bioreactors using computational fluid dynamics
Authors: Johnson, C. G.; Natarajan, Venkatesh; Antoniou, Chris
Year: 2014
Venue: Biotechnology Progress
Paper Development of small scale cell culture models for screening poloxamer 188 lot-to-lot variation.
Peng, Haofan; Hall, Kaitlyn M; Clayton, Blake et al. · 2014 · Biotechnology progress · DOI
Full title: Development of small scale cell culture models for screening poloxamer 188 lot-to-lot variation.
Authors: Peng, Haofan; Hall, Kaitlyn M; Clayton, Blake; Wiltberger, Kelly; Hu, Weiwei; Hughes, Erik; Kane, John; Ney, Rachel; Ryll, Thomas
Year: 2014
Venue: Biotechnology progress
Paper An automated RNA‐Seq analysis pipeline to identify and visualize differentially expressed genes and pathways in CHO cells
Chun Chen; Huong Le; C. Goudar · 2015 · Biotechnology progress (Print) · DOI
Full title: An automated RNA‐Seq analysis pipeline to identify and visualize differentially expressed genes and pathways in CHO cells
Authors: Chun Chen; Huong Le; C. Goudar
Year: 2015
Venue: Biotechnology progress (Print)
Paper A practical approach in bioreactor scale‐up and process transfer using a combination of constant <i>P</i>/<i>V</i> and vvm as the criterion
Xu, Sen; Hoshan, Linda; Jiang, Rubin et al. · 2017 · Biotechnology Progress · DOI
Full title: A practical approach in bioreactor scale‐up and process transfer using a combination of constant <i>P</i>/<i>V</i> and vvm as the criterion
Authors: Xu, Sen; Hoshan, Linda; Jiang, Rubin; Gupta, Balrina; Brodean, Eric; O'Neill, Kristin; Seamans, T. Craig; Bowers, J.S.; Chen, Hao
Year: 2017
Venue: Biotechnology Progress
Paper The effect of antiapoptosis genes on clarification performance.
Potty, Ajish S R; Xenopoulos, Alex; Patel, Sonal et al. · 2014 · Biotechnology progress · DOI
Full title: The effect of antiapoptosis genes on clarification performance.
Authors: Potty, Ajish S R; Xenopoulos, Alex; Patel, Sonal; Prentice, Holly; Dileo, Anthony
Year: 2014
Venue: Biotechnology progress
Paper Ultra scale-down approach to correct dispersive and retentive effects in small-scale columns when predicting larger scale elution profiles.
Hutchinson, N; Chhatre, S; Baldascini, H et al. · 2009 · Biotechnology progress · DOI
Full title: Ultra scale-down approach to correct dispersive and retentive effects in small-scale columns when predicting larger scale elution profiles.
Authors: Hutchinson, N; Chhatre, S; Baldascini, H; Davies, J L; Bracewell, D G; Hoare, M
Year: 2009
Venue: Biotechnology progress
Paper Application of multivariate analysis and mass transfer principles for refinement of a 3-L bioreactor scale-down model--when shake flasks mimic 15,000-L bioreactors better.
Ahuja, Sanjeev; Jain, Shilpa; Ram, Kripa · 2015 · Biotechnology progress · DOI
Full title: Application of multivariate analysis and mass transfer principles for refinement of a 3-L bioreactor scale-down model--when shake flasks mimic 15,000-L bioreactors better.
Authors: Ahuja, Sanjeev; Jain, Shilpa; Ram, Kripa
Year: 2015
Venue: Biotechnology progress
Paper High throughput automated microbial bioreactor system used for clone selection and rapid scale‐down process optimization
Velez‐Suberbie, M. Lourdes; Betts, John; Walker, Kelly L. et al. · 2017 · Biotechnology Progress · DOI
Full title: High throughput automated microbial bioreactor system used for clone selection and rapid scale‐down process optimization
Authors: Velez‐Suberbie, M. Lourdes; Betts, John; Walker, Kelly L.; Robinson, Colin; Zoro, Barney; Keshavarz‐Moore, Eli
Year: 2017
Venue: Biotechnology Progress
Paper Optimizing performance of semi-continuous cell culture in an ambr15™ microbioreactor using dynamic flux balance modeling.
Kelly, William; Veigne, Sorelle; Li, Xianhua et al. · 2018 · Biotechnology progress · DOI
Full title: Optimizing performance of semi-continuous cell culture in an ambr15™ microbioreactor using dynamic flux balance modeling.
Authors: Kelly, William; Veigne, Sorelle; Li, Xianhua; Subramanian, Shyam Sundar; Huang, Zuyi; Schaefer, Eugene
Year: 2018
Venue: Biotechnology progress
Paper Characterization of TAP Ambr 250 disposable bioreactors, as a reliable scale-down model for biologics process development.
Xu, Ping; Clark, Colleen; Ryder, Todd et al. · 2017 · Biotechnology progress · DOI
Full title: Characterization of TAP Ambr 250 disposable bioreactors, as a reliable scale-down model for biologics process development.
Authors: Xu, Ping; Clark, Colleen; Ryder, Todd; Sparks, Colleen; Zhou, Jiping; Wang, Michelle; Russell, Reb; Scott, Charo
Year: 2017
Venue: Biotechnology progress
Paper Evaluating manufacturing process profile comparability with multivariate equivalence testing: Case study of cell-culture small scale model transfer.
Cao, Yang; Obeng, Daniel; Hui, Guodong et al. · 2018 · Biotechnology progress · DOI
Full title: Evaluating manufacturing process profile comparability with multivariate equivalence testing: Case study of cell-culture small scale model transfer.
Authors: Cao, Yang; Obeng, Daniel; Hui, Guodong; Xue, Luting; Ren, Yukun; Yu, Xianjie; Wang, Fei; Atwell, Chad
Year: 2018
Venue: Biotechnology progress
Paper Application of high-throughput mini-bioreactor system for systematic scale-down modeling, process characterization, and control strategy development.
Janakiraman, Vijay; Kwiatkowski, Chris; Kshirsagar, Rashmi et al. · 2015 · Biotechnology progress · DOI
Full title: Application of high-throughput mini-bioreactor system for systematic scale-down modeling, process characterization, and control strategy development.
Authors: Janakiraman, Vijay; Kwiatkowski, Chris; Kshirsagar, Rashmi; Ryll, Thomas; Huang, Yao-Ming
Year: 2015
Venue: Biotechnology progress
Paper Identification of upstream culture conditions and harvest time parameters that affect host cell protein clearance
Wilson, Louisa J.; Lewis, Will; Kucia‐Tran, Richard et al. · 2019 · Biotechnology Progress · DOI
Full title: Identification of upstream culture conditions and harvest time parameters that affect host cell protein clearance
Authors: Wilson, Louisa J.; Lewis, Will; Kucia‐Tran, Richard; Bracewell, Daniel G.
Year: 2019
Venue: Biotechnology Progress
Paper A protocol to transfer a fed-batch platform process into semi-perfusion mode: The benefit of automated small-scale bioreactors compared to shake flasks as scale-down model.
Janoschek, Sabrina; Schulze, Markus; Zijlstra, Gerben et al. · 2019 · Biotechnology progress · DOI
Full title: A protocol to transfer a fed-batch platform process into semi-perfusion mode: The benefit of automated small-scale bioreactors compared to shake flasks as scale-down model.
Authors: Janoschek, Sabrina; Schulze, Markus; Zijlstra, Gerben; Greller, Gerhard; Matuszczyk, Jens
Year: 2019
Venue: Biotechnology progress
Paper Semi‐continuous scale‐down models for clone and operating parameter screening in perfusion bioreactors
Jean-Marc Bielser; Jakub Domaradzki; J. Souquet et al. · 2019 · Biotechnology progress (Print) · DOI
Full title: Semi‐continuous scale‐down models for clone and operating parameter screening in perfusion bioreactors
Authors: Jean-Marc Bielser; Jakub Domaradzki; J. Souquet; H. Broly; M. Morbidelli
Year: 2019
Venue: Biotechnology progress (Print)
Paper Novel electrodynamic oscillation technique enables enhanced mass transfer and mixing for cultivation in micro‐bioreactor
Frey, Lasse Jannis; Vorländer, David; Rasch, Detlev et al. · 2019 · Biotechnology Progress · DOI
Full title: Novel electrodynamic oscillation technique enables enhanced mass transfer and mixing for cultivation in micro‐bioreactor
Authors: Frey, Lasse Jannis; Vorländer, David; Rasch, Detlev; Ostsieker, Hendrik; Müller, Bernhard; Schulze, Moritz; Schenkendorf, René; Mayr, Torsten; Grosch, Jan‐Hendrik; Krull, Rainer
Year: 2019
Venue: Biotechnology Progress
Paper A novel scale‐down mimic of perfusion cell culture using sedimentation in an automated microbioreactor (SAM)
Kreye, Steffen; Stahn, Rainer; Nawrath, Karina et al. · 2019 · Biotechnology Progress · DOI
Full title: A novel scale‐down mimic of perfusion cell culture using sedimentation in an automated microbioreactor (SAM)
Authors: Kreye, Steffen; Stahn, Rainer; Nawrath, Karina; Goralczyk, Vicky; Zoro, Barney; Goletz, Steffen
Year: 2019
Venue: Biotechnology Progress
Paper Model‐based workflow for scale‐up of process strategies developed in miniaturized bioreactor systems
Arndt, Lukas; Wiegmann, Vincent; Kuchemüller, Kim B. et al. · 2021 · Biotechnology Progress · DOI
Full title: Model‐based workflow for scale‐up of process strategies developed in miniaturized bioreactor systems
Authors: Arndt, Lukas; Wiegmann, Vincent; Kuchemüller, Kim B.; Baganz, Frank; Pörtner, Ralf; Möller, Johannes
Year: 2021
Venue: Biotechnology Progress
Paper Microbioreactor ( micro‐Matrix ) potential in aerobic and anaerobic conditions with different industrially relevant microbial strains
D’ambrosio, Sergio; Ventrone, Michela; Alfano, Alberto et al. · 2021 · Biotechnology Progress · DOI
Full title: Microbioreactor ( micro‐Matrix ) potential in aerobic and anaerobic conditions with different industrially relevant microbial strains
Authors: D’ambrosio, Sergio; Ventrone, Michela; Alfano, Alberto; Schiraldi, Chiara; Cimini, Donatella
Year: 2021
Venue: Biotechnology Progress
Paper Scale-down model qualification of ambr® 250 high-throughput mini-bioreactor system for two commercial-scale mAb processes.
Manahan, Matthew; Nelson, Michael; Cacciatore, Jonathan J et al. · 2019 · Biotechnology progress · DOI
Full title: Scale-down model qualification of ambr® 250 high-throughput mini-bioreactor system for two commercial-scale mAb processes.
Authors: Manahan, Matthew; Nelson, Michael; Cacciatore, Jonathan J; Weng, Jessica; Xu, Sen; Pollard, Jennifer
Year: 2019
Venue: Biotechnology progress
Paper Development of a small-scale rotary lobe-pump cell culture model for examining cell damage in large-scale N-1 seed perfusion process.
Johnstone, Patrick; Mast, Elena; Hughes, Erik et al. · 2020 · Biotechnology progress · DOI
Full title: Development of a small-scale rotary lobe-pump cell culture model for examining cell damage in large-scale N-1 seed perfusion process.
Authors: Johnstone, Patrick; Mast, Elena; Hughes, Erik; Peng, Haofan
Year: 2020
Venue: Biotechnology progress
Paper High‐throughput screening of antibody‐expressing CHO clones using an automated shaken deep‐well system
Wang, Benjamin; Albanetti, Thomas; Miró-Quesada, Guillermo et al. · 2018 · Biotechnology Progress · DOI
Full title: High‐throughput screening of antibody‐expressing CHO clones using an automated shaken deep‐well system
Authors: Wang, Benjamin; Albanetti, Thomas; Miró-Quesada, Guillermo; Flack, Layla; Li, Lina; Klover, Judith; Burson, Kerri; Evans, Krista; Ivory, William; Bowen, Michael A.; Schoner, Ronald G.; Hawley‐Nelson, Pamela
Year: 2018
Venue: Biotechnology Progress
Paper Development of bioreactor scale-down model using orthogonal projections to latent structures method and CO2 supplementation.
Gao, Jinxin; Hazeltine, Laurie B; Stroud, Neal et al. · 2024 · Biotechnology progress · DOI
Full title: Development of bioreactor scale-down model using orthogonal projections to latent structures method and CO2 supplementation.
Authors: Gao, Jinxin; Hazeltine, Laurie B; Stroud, Neal; Liu, Ning; Huang, Yao-Ming
Year: 2024
Venue: Biotechnology progress
Paper Computational fluid dynamics analysis of mixing and gas–liquid mass transfer in wave bag bioreactor
Svay, Kirilynn; Urrea, Christine; Shamlou, P. Ayazi et al. · 2020 · Biotechnology Progress · DOI
Full title: Computational fluid dynamics analysis of mixing and gas–liquid mass transfer in wave bag bioreactor
Authors: Svay, Kirilynn; Urrea, Christine; Shamlou, P. Ayazi; Zhang, Hu
Year: 2020
Venue: Biotechnology Progress
Paper Cross-scale quality assessment of a mechanistic cation exchange chromatography model.
Saleh, David; Wang, Gang; Mueller, Benedict et al. · 2021 · Biotechnology progress · DOI
Full title: Cross-scale quality assessment of a mechanistic cation exchange chromatography model.
Authors: Saleh, David; Wang, Gang; Mueller, Benedict; Rischawy, Federico; Kluters, Simon; Studts, Joey; Hubbuch, Jürgen
Year: 2021
Venue: Biotechnology progress
Paper A strategy for clone selection under different production conditions.
Legmann, Rachel; Benoit, Brian; Fedechko, Ronald W et al. · 2011 · Biotechnology progress · DOI
Full title: A strategy for clone selection under different production conditions.
Authors: Legmann, Rachel; Benoit, Brian; Fedechko, Ronald W; Deppeler, Cynthia L; Srinivasan, Sriram; Robins, Russell H; McCormick, Ellen L; Ferrick, David A; Rodgers, Seth T; Russo, A Peter
Year: 2011
Venue: Biotechnology progress
Paper Modeling scalability of impurity precipitation in downstream biomanufacturing.
Guo, Jing; Traylor, Steven J; Agoub, Mohamed et al. · 2024 · Biotechnology progress · DOI
Full title: Modeling scalability of impurity precipitation in downstream biomanufacturing.
Authors: Guo, Jing; Traylor, Steven J; Agoub, Mohamed; Jin, Weixin; Hua, Helen; Diemer, R Bertrum; Xu, Xuankuo; Ghose, Sanchayita; Li, Zheng Jian; Lenhoff, Abraham M
Year: 2024
Venue: Biotechnology progress
Paper Application of quality by design principles to the development and technology transfer of a major process improvement for the manufacture of a recombinant protein.
Looby, Mairead; Ibarra, Neysi; Pierce, James J et al. · 2011 · Biotechnology progress · DOI
Full title: Application of quality by design principles to the development and technology transfer of a major process improvement for the manufacture of a recombinant protein.
Authors: Looby, Mairead; Ibarra, Neysi; Pierce, James J; Buckley, Kevin; O'Donovan, Eimear; Heenan, Mary; Moran, Enda; Farid, Suzanne S; Baganz, Frank
Year: 2011
Venue: Biotechnology progress
Paper Development of a high-throughput scale-down model in Ambr® 250 HT for plasmid DNA fermentation processes.
Fang, Shu; Sinanan, Dillon J; Perez, Marc H et al. · 2024 · Biotechnology progress · DOI
Full title: Development of a high-throughput scale-down model in Ambr® 250 HT for plasmid DNA fermentation processes.
Authors: Fang, Shu; Sinanan, Dillon J; Perez, Marc H; Cruz-Quintero, Raúl G; Jadhav, Sachin R
Year: 2024
Venue: Biotechnology progress
Paper pH measurement and a rational and practical pH control strategy for high throughput cell culture system.
Zhou, Haiying; Purdie, Jennifer; Wang, Tongtong et al. · 2010 · Biotechnology progress · DOI
Full title: pH measurement and a rational and practical pH control strategy for high throughput cell culture system.
Authors: Zhou, Haiying; Purdie, Jennifer; Wang, Tongtong; Ouyang, Anli
Year: 2010
Venue: Biotechnology progress
Paper Characterization and feasibility of a miniaturized stirred tank bioreactor to perform <i>E. coli</i> high cell density fed‐batch fermentations
Ali, Shaukat; Perez‐Pardo, Miguel Angel; Aucamp, Jean P. et al. · 2011 · Biotechnology Progress · DOI
Full title: Characterization and feasibility of a miniaturized stirred tank bioreactor to perform <i>E. coli</i> high cell density fed‐batch fermentations
Authors: Ali, Shaukat; Perez‐Pardo, Miguel Angel; Aucamp, Jean P.; Craig, Alan; Bracewell, Daniel G.; Baganz, Frank
Year: 2011
Venue: Biotechnology Progress
Paper Integration of microbial kinetics and fluid dynamics toward model‐driven scale‐up of industrial bioprocesses
Wang, Guan; Tang, Wenjun; Xia, Jianye et al. · 2014 · Engineering in Life Sciences · DOI
Full title: Integration of microbial kinetics and fluid dynamics toward model‐driven scale‐up of industrial bioprocesses
Authors: Wang, Guan; Tang, Wenjun; Xia, Jianye; Chu, Ju; Noorman, Henk; Gulik, Walter M. van
Year: 2014
Venue: Engineering in Life Sciences
Paper Development of a method for reliable power input measurements in conventional and single‐use stirred bioreactors at laboratory scale
Kaiser, Stephan C.; Werner, Sören; Jossen, Valentin et al. · 2016 · Engineering in Life Sciences · DOI
Full title: Development of a method for reliable power input measurements in conventional and single‐use stirred bioreactors at laboratory scale
Authors: Kaiser, Stephan C.; Werner, Sören; Jossen, Valentin; Kraume, Matthias; Eibl, Dieter
Year: 2016
Venue: Engineering in Life Sciences
Paper Editorial: How can we ensure the successful transfer from lab‐ to large‐scale production?
Takors, Ralf · 2016 · Engineering in Life Sciences · DOI
Full title: Editorial: How can we ensure the successful transfer from lab‐ to large‐scale production?
Authors: Takors, Ralf
Year: 2016
Venue: Engineering in Life Sciences
Paper Influence of fructose and oxygen gradients on fed‐batch recombinant protein production using <i>Bacillus megaterium</i>
Korneli, Claudia; David, Florian; Godard, Thibault et al. · 2011 · Engineering in Life Sciences · DOI
Full title: Influence of fructose and oxygen gradients on fed‐batch recombinant protein production using <i>Bacillus megaterium</i>
Authors: Korneli, Claudia; David, Florian; Godard, Thibault; Franco‐Lara, Ezequiel
Year: 2011
Venue: Engineering in Life Sciences
Paper Plug flow versus stirred tank reactor flow characteristics in two‐compartment scale‐down bioreactor: Setup‐specific influence on the metabolic phenotype and bioprocess performance of <i>Corynebacterium glutamicum</i>
Limberg, Michael; Pooth, Viola; Wiechert, Wolfgang et al. · 2016 · Engineering in Life Sciences · DOI
Full title: Plug flow versus stirred tank reactor flow characteristics in two‐compartment scale‐down bioreactor: Setup‐specific influence on the metabolic phenotype and bioprocess performance of <i>Corynebacterium glutamicum</i>
Authors: Limberg, Michael; Pooth, Viola; Wiechert, Wolfgang; Oldiges, Marco
Year: 2016
Venue: Engineering in Life Sciences
Paper Euler‐Lagrange computational fluid dynamics for (bio)reactor scale down: An analysis of organism lifelines
Haringa, Cees; Tang, Wenjun; Deshmukh, Amit T. et al. · 2016 · Engineering in Life Sciences · DOI
Full title: Euler‐Lagrange computational fluid dynamics for (bio)reactor scale down: An analysis of organism lifelines
Authors: Haringa, Cees; Tang, Wenjun; Deshmukh, Amit T.; Xia, Jianye; Reuß, Matthias; Heijnen, Joseph J.; Mudde, R.F.; Noorman, Henk
Year: 2016
Venue: Engineering in Life Sciences
Paper Performance loss of <i>Corynebacterium glutamicum</i> cultivations under scale‐down conditions using complex media
Lemoine, Anja; Limberg, Michael; Kästner, Steffen et al. · 2016 · Engineering in Life Sciences · DOI
Full title: Performance loss of <i>Corynebacterium glutamicum</i> cultivations under scale‐down conditions using complex media
Authors: Lemoine, Anja; Limberg, Michael; Kästner, Steffen; Oldiges, Marco; Neubauer, Peter; Junne, Stefan
Year: 2016
Venue: Engineering in Life Sciences
Paper Development, characterization, and application of a 2‐Compartment system to investigate the impact of pH inhomogeneities in large‐scale CHO‐based processes
Paul, Katrin; Böttinger, Katharina; Mitic, Bernd M. et al. · 2020 · Engineering in Life Sciences · DOI
Full title: Development, characterization, and application of a 2‐Compartment system to investigate the impact of pH inhomogeneities in large‐scale CHO‐based processes
Authors: Paul, Katrin; Böttinger, Katharina; Mitic, Bernd M.; Scherfler, Georg; Posch, C.; Behrens, Dirk; Huber, Christian G.; Herwig, Christoph
Year: 2020
Venue: Engineering in Life Sciences
Paper Mathematical modeling and simulation studies of scale‐down fermentation systems
Özbek, Belma · 1997 · Chemical Engineering & Technology · DOI
Full title: Mathematical modeling and simulation studies of scale‐down fermentation systems
Authors: Özbek, Belma
Year: 1997
Venue: Chemical Engineering & Technology
Paper Microbial population heterogeneity versus bioreactor heterogeneity: Evaluation of Redox Sensor Green as an exogenous metabolic biosensor
Baert, Jonathan; Delepierre, Anissa; Telek, Samuel et al. · 2016 · Engineering in Life Sciences · DOI
Full title: Microbial population heterogeneity versus bioreactor heterogeneity: Evaluation of Redox Sensor Green as an exogenous metabolic biosensor
Authors: Baert, Jonathan; Delepierre, Anissa; Telek, Samuel; Fickers, Patrick; Toye, Dominique; Lamotte, Anne de; Lara, Alvaro R.; Jaén, Karim E.; Gosset, Guillermo; Jensen, Peter Ruhdal; Delvigne, Frank
Year: 2016
Venue: Engineering in Life Sciences
Paper Scale‐down simulators for mammalian cell culture as tools to access the impact of inhomogeneities occurring in large‐scale bioreactors
Paul, Katrin; Herwig, Christoph · 2020 · Engineering in Life Sciences · DOI
Full title: Scale‐down simulators for mammalian cell culture as tools to access the impact of inhomogeneities occurring in large‐scale bioreactors
Authors: Paul, Katrin; Herwig, Christoph
Year: 2020
Venue: Engineering in Life Sciences
Paper An analysis of organism lifelines in an industrial bioreactor using Lattice‐Boltzmann CFD
Haringa, Cees · 2022 · Engineering in Life Sciences · DOI
Full title: An analysis of organism lifelines in an industrial bioreactor using Lattice‐Boltzmann CFD
Authors: Haringa, Cees
Year: 2022
Venue: Engineering in Life Sciences
Paper A perspective‐driven and technical evaluation of machine learning in bioreactor scale‐up: A case‐study for potential model developments
Alavijeh, Masih Karimi; Lee, Yih Yean; Gras, Sally L. · 2024 · Engineering in Life Sciences · DOI
Full title: A perspective‐driven and technical evaluation of machine learning in bioreactor scale‐up: A case‐study for potential model developments
Authors: Alavijeh, Masih Karimi; Lee, Yih Yean; Gras, Sally L.
Year: 2024
Venue: Engineering in Life Sciences
Paper Investigation of cell line specific responses to pH inhomogeneity and consequences for process design
Paul, Katrin; Hartmann, Thomas; Posch, C. et al. · 2020 · Engineering in Life Sciences · DOI
Full title: Investigation of cell line specific responses to pH inhomogeneity and consequences for process design
Authors: Paul, Katrin; Hartmann, Thomas; Posch, C.; Behrens, Dirk; Herwig, Christoph
Year: 2020
Venue: Engineering in Life Sciences
Paper Modelling concentration gradients in fed-batch cultivations of E. coli
Emmanuel Anane, A. Sawatzki, P. Neubauer, M. Cruz-Bournazou · 2018 · Journal of Chemical Technology & Biotechnology · DOI
Full title: Modelling concentration gradients in fed-batch cultivations of E. coli
Authors: Emmanuel Anane, A. Sawatzki, P. Neubauer, M. Cruz-Bournazou
Year: 2018
Venue: Journal of Chemical Technology & Biotechnology
Paper Scaling‐down biopharmaceutical production processes via a single multi‐compartment bioreactor (SMCB)
Gaugler, Lena; Mast, Yannic; Fitschen, Jürgen et al. · 2022 · Engineering in Life Sciences · DOI
Full title: Scaling‐down biopharmaceutical production processes via a single multi‐compartment bioreactor (SMCB)
Authors: Gaugler, Lena; Mast, Yannic; Fitschen, Jürgen; Hofmann, Sebastian; Schlüter, Michael; Takors, Ralf
Year: 2022
Venue: Engineering in Life Sciences
Paper Development of parallel miniature bubble column bioreactors for fermentation process
Soheila Kheradmandnia; S. Hashemi-Najafabadi; S. Shojaosadati et al. · 2015 · Journal of Chemical Technology & Biotechnology · DOI
Full title: Development of parallel miniature bubble column bioreactors for fermentation process
Authors: Soheila Kheradmandnia; S. Hashemi-Najafabadi; S. Shojaosadati; S. Mousavi; K. Khosravi
Year: 2015
Venue: Journal of Chemical Technology & Biotechnology
Paper Process adapted calibration improves fluorometric pH sensor precision in sophisticated fermentation processes.
Newton, Joseph; Oeggl, Reinhard; Janzen, Nils H et al. · 2020 · Engineering in life sciences · DOI
Full title: Process adapted calibration improves fluorometric pH sensor precision in sophisticated fermentation processes.
Authors: Newton, Joseph; Oeggl, Reinhard; Janzen, Nils H; Abad, Sandra; Reinisch, Daniela
Year: 2020
Venue: Engineering in life sciences
Paper Experimental and <i>in silico</i> investigation of population heterogeneity in continuous <i>Sachharomyces cerevisiae</i> scale‐down fermentation in a two‐compartment setup
Heins, Anna‐Lena; Fernandes, Rita Lencastre; Gernaey, Krist V. et al. · 2014 · Journal of Chemical Technology & Biotechnology · DOI
Full title: Experimental and <i>in silico</i> investigation of population heterogeneity in continuous <i>Sachharomyces cerevisiae</i> scale‐down fermentation in a two‐compartment setup
Authors: Heins, Anna‐Lena; Fernandes, Rita Lencastre; Gernaey, Krist V.; Lantz, Anna Eliasson
Year: 2014
Venue: Journal of Chemical Technology & Biotechnology
Paper Influence of oxygen concentration on the metabolism of Penicillium chrysogenum
Janoska, Agnes; Verheijen, Jelle J.; Tang, Wenjung et al. · 2022 · Engineering in Life Sciences · DOI
Full title: Influence of oxygen concentration on the metabolism of Penicillium chrysogenum
Authors: Janoska, Agnes; Verheijen, Jelle J.; Tang, Wenjung; Lee, Queenie; Sikkema, Baukje; Gulik, Walter M. van
Year: 2022
Venue: Engineering in Life Sciences
Paper Development of an original approach to evaluate effects of surfactants, biomass and pollutants on the scaling‐up of a two‐phase partitioning bioreactor
Aldric, Jean‐Marc; Gillet, Sébastien; Delvigne, Frank et al. · 2010 · Journal of Chemical Technology & Biotechnology · DOI
Full title: Development of an original approach to evaluate effects of surfactants, biomass and pollutants on the scaling‐up of a two‐phase partitioning bioreactor
Authors: Aldric, Jean‐Marc; Gillet, Sébastien; Delvigne, Frank; Thonart, Philippe
Year: 2010
Venue: Journal of Chemical Technology & Biotechnology
Paper Shake tube perfusion cell cultures are suitable tools for the prediction of limiting substrate, CSPR , bleeding strategy, growth and productivity behavior
Mayrhofer, Patrick; Castan, Andreas; Kunert, Renate · 2021 · Journal of Chemical Technology & Biotechnology · DOI
Full title: Shake tube perfusion cell cultures are suitable tools for the prediction of limiting substrate, CSPR , bleeding strategy, growth and productivity behavior
Authors: Mayrhofer, Patrick; Castan, Andreas; Kunert, Renate
Year: 2021
Venue: Journal of Chemical Technology & Biotechnology
Paper Design and characterization of a one‐compartment scale‐down system for simulating dissolved oxygen tension gradients
León‐Rodríguez, Antonio De; Galindo, Enrique; Ramı́rez, Octavio T. · 2010 · Journal of Chemical Technology & Biotechnology · DOI
Full title: Design and characterization of a one‐compartment scale‐down system for simulating dissolved oxygen tension gradients
Authors: León‐Rodríguez, Antonio De; Galindo, Enrique; Ramı́rez, Octavio T.
Year: 2010
Venue: Journal of Chemical Technology & Biotechnology
Paper Insight into the large‐scale upstream fermentation environment using scaled‐down models
Olughu, Williams; Deepika, G.; Hewitt, Christopher J. et al. · 2018 · Journal of Chemical Technology & Biotechnology · DOI
Full title: Insight into the large‐scale upstream fermentation environment using scaled‐down models
Authors: Olughu, Williams; Deepika, G.; Hewitt, Christopher J.; Rielly, Chris D.
Year: 2018
Venue: Journal of Chemical Technology & Biotechnology
Paper Transcriptomics as a tool for assessing the scalability of mammalian cell perfusion systems.
Jayapal, Karthik P; Goudar, Chetan T · 2014 · Advances in biochemical engineering/biotechnology · DOI
Full title: Transcriptomics as a tool for assessing the scalability of mammalian cell perfusion systems.
Authors: Jayapal, Karthik P; Goudar, Chetan T
Year: 2014
Venue: Advances in biochemical engineering/biotechnology
Paper Tools for High-Throughput Medium and Process Optimization
Jordan, Martin; Jenkins, Nigel · 2007 · Methods in biotechnology · DOI
Full title: Tools for High-Throughput Medium and Process Optimization
Authors: Jordan, Martin; Jenkins, Nigel
Year: 2007
Venue: Methods in biotechnology
Paper Microbioreactors and Scale-Down Models: Growth of CHO Cells Using the Pall Micro24 MicroReactor System
Warr, Steve · 2013 · Methods in molecular biology · DOI
Full title: Microbioreactors and Scale-Down Models: Growth of CHO Cells Using the Pall Micro24 MicroReactor System
Authors: Warr, Steve
Year: 2013
Venue: Methods in molecular biology
Paper Sterol synthesis and cell size distribution under oscillatory growth conditions in <i>Saccharomyces cerevisiae</i> scale‐down cultivations
Marbà‐Ardébol, Anna‐Maria; Bockisch, Anika; Neubauer, Peter et al. · 2017 · Yeast · DOI
Full title: Sterol synthesis and cell size distribution under oscillatory growth conditions in <i>Saccharomyces cerevisiae</i> scale‐down cultivations
Authors: Marbà‐Ardébol, Anna‐Maria; Bockisch, Anika; Neubauer, Peter; Junne, Stefan
Year: 2017
Venue: Yeast
Paper Importance of the cultivation history for the response of Escherichia coli to oscillations in scale-down experiments.
Brand, Eva; Junne, Stefan; Anane, Emmanuel et al. · 2018 · Bioprocess and biosystems engineering · DOI
Full title: Importance of the cultivation history for the response of Escherichia coli to oscillations in scale-down experiments.
Authors: Brand, Eva; Junne, Stefan; Anane, Emmanuel; Cruz-Bournazou, Mariano Nicolas; Neubauer, Peter
Year: 2018
Venue: Bioprocess and biosystems engineering
Paper Scale-Up Considerations Based on Studies at the Bench Scale in Stirred Bioreactors
Nienow, Alvin W. · 2009 · JOURNAL OF CHEMICAL ENGINEERING OF JAPAN · DOI
Full title: Scale-Up Considerations Based on Studies at the Bench Scale in Stirred Bioreactors
Authors: Nienow, Alvin W.
Year: 2009
Venue: JOURNAL OF CHEMICAL ENGINEERING OF JAPAN
Paper Development, characterization, and application of a novel scale-down apparatus for the investigation of the scale-up dependent CO2/HCO3– stimulus in Corynebacterium glutamicum
Buchholz, Jens · 2015 · OPUS Publication Server of the University of Stuttgart (University of Stuttgart) · DOI
Full title: Development, characterization, and application of a novel scale-down apparatus for the investigation of the scale-up dependent CO2/HCO3– stimulus in Corynebacterium glutamicum
Authors: Buchholz, Jens
Year: 2015
Venue: OPUS Publication Server of the University of Stuttgart (University of Stuttgart)
Paper Culture Miniaturization of Lipase Production by Yarrowia lipolytica
Santos, Ariane Gaspar; Ribeiro, Bernardo Dias; Nascimento, Felipe et al. · 2018 · Current Biochemical Engineering · DOI
Full title: Culture Miniaturization of Lipase Production by Yarrowia lipolytica
Authors: Santos, Ariane Gaspar; Ribeiro, Bernardo Dias; Nascimento, Felipe; Coelho, Maria Alice Zarur
Year: 2018
Venue: Current Biochemical Engineering
Paper Using computational fluid dynamics simulation improves the design and subsequent characterization of a plug-flow type scale-down reactor for microbial cultivation processes
Mayer, Florian; Cserjan‐Puschmann, Monika; Haslinger, Benedikt et al. · 2022 · DOI
Full title: Using computational fluid dynamics simulation improves the design and subsequent characterization of a plug-flow type scale-down reactor for microbial cultivation processes
Authors: Mayer, Florian; Cserjan‐Puschmann, Monika; Haslinger, Benedikt; Shpylovyi, Anton; Sam, Christian; Šoóš, Miroslav; Hahn, Rainer; Striedner, Gerald
Year: 2022
Paper Reconstruction of Industrial Processes for Cultivating CHO Cells in a Scale-Down Bioreactor Model
A. N. Morozov; Z. V. Zakharov; S. Kalenov et al. · 2021 · Biotekhnologiya · DOI
Full title: Reconstruction of Industrial Processes for Cultivating CHO Cells in a Scale-Down Bioreactor Model
Authors: A. N. Morozov; Z. V. Zakharov; S. Kalenov; R. Khamitov
Year: 2021
Venue: Biotekhnologiya
Paper Novel spiking methods developed for anion exchange chromatography operating in continuous processing
Y. Li; Audrey-Chingzu Chang; D. Beattie et al. · 2020 · DOI
Full title: Novel spiking methods developed for anion exchange chromatography operating in continuous processing
Authors: Y. Li; Audrey-Chingzu Chang; D. Beattie; K. Remington
Year: 2020
Paper Engineering Considerations for Process Development in Mammalian Cell Cultivation
Zhang, Hu; Wang, Weixiang; Quan, Chunshan et al. · 2010 · Current Pharmaceutical Biotechnology · DOI
Full title: Engineering Considerations for Process Development in Mammalian Cell Cultivation
Authors: Zhang, Hu; Wang, Weixiang; Quan, Chunshan; Sheng-di, Fan
Year: 2010
Venue: Current Pharmaceutical Biotechnology
Paper An industrial perspective on in vivo kinetics of central metabolite pools and dynamic flux responses in Penicillium chrysogenum during periodic dissolved oxygen feast-famine cycles in a scale-down system
Wang, Guan; Wang, Xueting; Yang, Qi et al. · 2023 · DOI
Full title: An industrial perspective on in vivo kinetics of central metabolite pools and dynamic flux responses in Penicillium chrysogenum during periodic dissolved oxygen feast-famine cycles in a scale-down system
Authors: Wang, Guan; Wang, Xueting; Yang, Qi; Haringa, Cees; Wang, Zejian; Chu, Ju; Zhuang, Yingping
Year: 2023
Paper Perfusion-Based Antibody Production in the Ambr® 250 Modular.
Ott, Vivian; Ott, Jan; Mannone, Andry D et al. · 2025 · Chimia · DOI
Full title: Perfusion-Based Antibody Production in the Ambr® 250 Modular.
Authors: Ott, Vivian; Ott, Jan; Mannone, Andry D; Eibl, Regine
Year: 2025
Venue: Chimia
Paper Hydrodynamics of a model stirred anaerobic digester
Montante, Giuseppina; Paglianti, Alessandro · 2014 · Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) · DOI
Full title: Hydrodynamics of a model stirred anaerobic digester
Authors: Montante, Giuseppina; Paglianti, Alessandro
Year: 2014
Venue: Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna)
Paper Developing an effective scale-down model for a suspension adapted HEK293T-derived lentiviral vector stable producer cell line
Patel, Hamza; Archibald, Peter; Jung, Cindy et al. · 2021 · DOI
Full title: Developing an effective scale-down model for a suspension adapted HEK293T-derived lentiviral vector stable producer cell line
Authors: Patel, Hamza; Archibald, Peter; Jung, Cindy; Roszell, Blair; Veraitch, Farlan; Rafiq, Qasim A.; Micheletti, Martina
Year: 2021
Paper A Review of Computational Fluid Dynamics (CFD) Simulations of Mixing in the Pharmaceutical Industry
Pohar, Andrej · 2020 · Biomedical Journal of Scientific & Technical Research · DOI
Full title: A Review of Computational Fluid Dynamics (CFD) Simulations of Mixing in the Pharmaceutical Industry
Authors: Pohar, Andrej
Year: 2020
Venue: Biomedical Journal of Scientific & Technical Research
Paper Potential effects of roadside dry wells on groundwater quality on the Island of Hawai&#x27;i — Assessment using numerical groundwater models
Izuka, Scot K. · 2011 · Scientific investigations report · DOI
Full title: Potential effects of roadside dry wells on groundwater quality on the Island of Hawai&#x27;i — Assessment using numerical groundwater models
Authors: Izuka, Scot K.
Year: 2011
Venue: Scientific investigations report
Paper Intracellular Profiling for Biopharmaceutical Cultivation Processes
Maroto, Vania Bertrand · 2018 · Repository for Publications and Research Data (ETH Zurich) · DOI
Full title: Intracellular Profiling for Biopharmaceutical Cultivation Processes
Authors: Maroto, Vania Bertrand
Year: 2018
Venue: Repository for Publications and Research Data (ETH Zurich)
Paper The Engineering of a Scalable Disposable Orbitally Shaken Bioreactor System for Animal Cell Cultivation and Therapeutic Protein Production
Monteil · 2014 · Infoscience (Ecole Polytechnique Fédérale de Lausanne) · DOI
Full title: The Engineering of a Scalable Disposable Orbitally Shaken Bioreactor System for Animal Cell Cultivation and Therapeutic Protein Production
Authors: Monteil
Year: 2014
Venue: Infoscience (Ecole Polytechnique Fédérale de Lausanne)
Paper Amino Acid Fermentation: Evaluation of Scale-Down Capabili- ties Using DASbox ® Mini Bioreactors
Schlottbom, Christiane; Kleebank, Sebastian; Hauser, Manuela et al. · 2013
Full title: Amino Acid Fermentation: Evaluation of Scale-Down Capabili- ties Using DASbox ® Mini Bioreactors
Authors: Schlottbom, Christiane; Kleebank, Sebastian; Hauser, Manuela; Hans, Stephan
Year: 2013
Paper Application of flow cytometry analysis to elucidate the impact of scale-down conditions in Escherichia coli cultivations P. Gil Salvador 2013 Award in Bioengineering category. (November 22, 2013 in the Annual General Assembly of the AIQS)
Marbà-Ardébol, Anna Maria; Turón, Xavier; Neubauer, Peter et al. · 2016 · RACO (Revistes Catalanes amb Accés Obert) (Consorci de Serveis Universitaris de Catalunya)
Full title: Application of flow cytometry analysis to elucidate the impact of scale-down conditions in Escherichia coli cultivations P. Gil Salvador 2013 Award in Bioengineering category. (November 22, 2013 in the Annual General Assembly of the AIQS)
Authors: Marbà-Ardébol, Anna Maria; Turón, Xavier; Neubauer, Peter; Junne, Stefan
Year: 2016
Venue: RACO (Revistes Catalanes amb Accés Obert) (Consorci de Serveis Universitaris de Catalunya)
Paper Application of flow cytometry analysis to elucidate the impact of scale-down conditions in Escherichia coli cultivations P. Gil Salvador 2013 Award in Bioengineering category. (November 22, 2013 in the Annual General Assembly of the AIQS)
Marbà-Ardébol, Anna Maria; Turón, Xavier; Neubauer, Peter et al. · 2016 · RACO (Revistes Catalanes amb Accés Obert) (Consorci de Serveis Universitaris de Catalunya)
Full title: Application of flow cytometry analysis to elucidate the impact of scale-down conditions in Escherichia coli cultivations P. Gil Salvador 2013 Award in Bioengineering category. (November 22, 2013 in the Annual General Assembly of the AIQS)
Authors: Marbà-Ardébol, Anna Maria; Turón, Xavier; Neubauer, Peter; Junne, Stefan
Year: 2016
Venue: RACO (Revistes Catalanes amb Accés Obert) (Consorci de Serveis Universitaris de Catalunya)
Paper A study of fermentation heterogeneity in a pilot scale airlift bioreactor
Pollard, David · 1995 · UCL Discovery (University College London)
Full title: A study of fermentation heterogeneity in a pilot scale airlift bioreactor
Authors: Pollard, David
Year: 1995
Venue: UCL Discovery (University College London)
Paper Characterization of bioreactors and scaling down of Escherichia coli culture in a vaccine manufacturing process
Medina, Nathalia Andrea Carreño · 2024 · Universidad Industrial de Santander
Full title: Characterization of bioreactors and scaling down of Escherichia coli culture in a vaccine manufacturing process
Authors: Medina, Nathalia Andrea Carreño
Year: 2024
Venue: Universidad Industrial de Santander
Paper Control of Proteolysis of Recombinant Proteins in Escherichia coli
Rozkov, Aleksei · 2001
Full title: Control of Proteolysis of Recombinant Proteins in Escherichia coli
Authors: Rozkov, Aleksei
Year: 2001
Paper Characterization and Scalability Assessment of a Parallel Single-Use Bioreactor System for Mammalian Cell Culture
Clark, Colleen E. · 2020 · UCL Discovery (University College London)
Full title: Characterization and Scalability Assessment of a Parallel Single-Use Bioreactor System for Mammalian Cell Culture
Authors: Clark, Colleen E.
Year: 2020
Venue: UCL Discovery (University College London)
Paper Design and characterisation of a parallel miniaturised bioreactor system for mammalian cell culture
O. Al-Ramadhani · 2015 · UCL Discovery (University College London)
Full title: Design and characterisation of a parallel miniaturised bioreactor system for mammalian cell culture
Authors: O. Al-Ramadhani
Year: 2015
Venue: UCL Discovery (University College London)
Paper Cultivation of Human CAP ® Cells: Evaluation of Scale-Down Capabili- ties using Single-Use Bioreactors
Hüther-Franken, Claudia M.; Kewes, Helmut; Schomberg, Michael · 2013
Full title: Cultivation of Human CAP ® Cells: Evaluation of Scale-Down Capabili- ties using Single-Use Bioreactors
Authors: Hüther-Franken, Claudia M.; Kewes, Helmut; Schomberg, Michael
Year: 2013
Paper Development and Automation of Microturbulence Intensifying Systems and Biosynthesis Conditions in Bioreactors
Viesturs, U. · 2007 · SHILAP Revista de lepidopterología
Full title: Development and Automation of Microturbulence Intensifying Systems and Biosynthesis Conditions in Bioreactors
Authors: Viesturs, U.
Year: 2007
Venue: SHILAP Revista de lepidopterología
Paper Evaluation of microwell based systems and miniature bioreactors for rapid cell culture bioprocess development and scale-up
Sani, Mohd Helmi · 2015 · UCL Discovery (University College London)
Full title: Evaluation of microwell based systems and miniature bioreactors for rapid cell culture bioprocess development and scale-up
Authors: Sani, Mohd Helmi
Year: 2015
Venue: UCL Discovery (University College London)
Paper Identification des critères d’extrapolation du procédé de production de cellulases par Trichoderma reesei en utilisant l’approche « scale-down »
Hardy, Nicolas · 2016 · HAL (Le Centre pour la Communication Scientifique Directe)
Full title: Identification des critères d’extrapolation du procédé de production de cellulases par Trichoderma reesei en utilisant l’approche « scale-down »
Authors: Hardy, Nicolas
Year: 2016
Venue: HAL (Le Centre pour la Communication Scientifique Directe)
Paper Influence of fungal morphology on the performance of industrial fermentation processes for enzyme production
Hernandez, Daniela Alejandra Quintanilla · 2017
Full title: Influence of fungal morphology on the performance of industrial fermentation processes for enzyme production
Authors: Hernandez, Daniela Alejandra Quintanilla
Year: 2017
Paper Incorporation of developability into cell line selection
Betts, John · 2015 · UCL Discovery (University College London)
Full title: Incorporation of developability into cell line selection
Authors: Betts, John
Year: 2015
Venue: UCL Discovery (University College London)
Paper pH fluctuations imperil the robustness of C. glutamicum to short term oxygen limitation.
Limberg, Michael H; Joachim, Mathias; Klein, Bianca et al. · 2017 · Journal of biotechnology · DOI
Full title: pH fluctuations imperil the robustness of C. glutamicum to short term oxygen limitation.
Authors: Limberg, Michael H; Joachim, Mathias; Klein, Bianca; Wiechert, Wolfgang; Oldiges, Marco
Year: 2017
Venue: Journal of biotechnology
Paper A robust scale-down model development and process characterization for monoclonal antibody biomanufacturing using multivariate data analysis.
Han, Sung-Hyuk; Park, Seo-Young; Cha, Hyun-Myoung et al. · 2025 · Journal of biotechnology · DOI
Full title: A robust scale-down model development and process characterization for monoclonal antibody biomanufacturing using multivariate data analysis.
Authors: Han, Sung-Hyuk; Park, Seo-Young; Cha, Hyun-Myoung; Lee, Kwang-Bae; Lim, Jin-Hyuk; Lee, Dong-Yup
Year: 2025
Venue: Journal of biotechnology
Paper AAV vector production: Troublesome host innate responses in another setting
Wright, J. Fraser · 2023 · Molecular Therapy — Methods & Clinical Development · DOI
Full title: AAV vector production: Troublesome host innate responses in another setting
Authors: Wright, J. Fraser
Year: 2023
Venue: Molecular Therapy — Methods & Clinical Development
Paper Multi-parameter process optimization for high yield AAV2 vector production using scale-down multi-parallel bioreactor systems and high-throughput analytical tools.
Wagner, Nazgul; Austerjost, Jonas; Niemann, Julia · 2026 · Journal of biotechnology · DOI
Full title: Multi-parameter process optimization for high yield AAV2 vector production using scale-down multi-parallel bioreactor systems and high-throughput analytical tools.
Authors: Wagner, Nazgul; Austerjost, Jonas; Niemann, Julia
Year: 2026
Venue: Journal of biotechnology
Paper Predicting the influence of combined oxygen and glucose gradients based on scale-down and modelling approaches for the scale-up of penicillin fermentations
Janoska, Agnes; Buijs, Joran; Gulik, Walter M. van · 2022 · Process Biochemistry · DOI
Full title: Predicting the influence of combined oxygen and glucose gradients based on scale-down and modelling approaches for the scale-up of penicillin fermentations
Authors: Janoska, Agnes; Buijs, Joran; Gulik, Walter M. van
Year: 2022
Venue: Process Biochemistry
Paper A scale-down model of 4000-L cell culture process for inactivated foot-and-mouth disease vaccine production.
Li, Xin-Ran; Yang, Yan-Kun; Wang, Rong-Bin et al. · 2019 · Vaccine · DOI
Full title: A scale-down model of 4000-L cell culture process for inactivated foot-and-mouth disease vaccine production.
Authors: Li, Xin-Ran; Yang, Yan-Kun; Wang, Rong-Bin; An, Fang-Lan; Zhang, Yun-De; Nie, Jian-Qi; Ahamada, Hadji; Liu, Xiu-Xia; Liu, Chun-Li; Deng, Yu; Bai, Zhong-Hu; Li, Ye; Liu, Xue-Rong
Year: 2019
Venue: Vaccine
Paper The use of dissolved oxygen-controlled, fed-batch aerobic cultivation for recombinant protein subunit vaccine manufacturing.
Farrell, Patrick; Sun, Jacob; Champagne, Paul-Philippe et al. · 2015 · Vaccine · DOI
Full title: The use of dissolved oxygen-controlled, fed-batch aerobic cultivation for recombinant protein subunit vaccine manufacturing.
Authors: Farrell, Patrick; Sun, Jacob; Champagne, Paul-Philippe; Lau, Heron; Gao, Meg; Sun, Hong; Zeiser, Arno; D'Amore, Tony
Year: 2015
Venue: Vaccine
Paper Production Process Development of Pseudorabies Virus Vaccine by Using a Novel Scale-Down Model of a Fixed-Bed Bioreactor.
Nie, Jianqi; Sun, Yang; Peng, Feng et al. · 2020 · Journal of pharmaceutical sciences · DOI
Full title: Production Process Development of Pseudorabies Virus Vaccine by Using a Novel Scale-Down Model of a Fixed-Bed Bioreactor.
Authors: Nie, Jianqi; Sun, Yang; Peng, Feng; Li, Xinran; Yang, Yankun; Liu, Xiuxia; Li, Ye; Liu, Chunli; Bai, Zhonghu
Year: 2020
Venue: Journal of pharmaceutical sciences
Paper Stochastic Models To Study the Impact of Mixing on a Fed-Batch Culture of Saccharomyces cerevisiae
Delvign, F.; Lejeune, Annick; Destain, Jacqueline et al. · 2006 · Biotechnology Progress · DOI
Full title: Stochastic Models To Study the Impact of Mixing on a Fed-Batch Culture of Saccharomyces cerevisiae
Authors: Delvign, F.; Lejeune, Annick; Destain, Jacqueline; Thonart, Philippe
Year: 2006
Venue: Biotechnology Progress
Paper Computational Fluid Dynamics Modeling of Steady‐State Momentum and Mass Transport in a Bioreactor for Cartilage Tissue Engineering
Williams, Kenneth; Saini, Sunil Kumar; Wick, Timothy M. · 2002 · Biotechnology Progress · DOI
Full title: Computational Fluid Dynamics Modeling of Steady‐State Momentum and Mass Transport in a Bioreactor for Cartilage Tissue Engineering
Authors: Williams, Kenneth; Saini, Sunil Kumar; Wick, Timothy M.
Year: 2002
Venue: Biotechnology Progress
Paper Characterization and Application of a Miniature 10 mL Stirred-Tank Bioreactor, Showing Scale-Down Equivalence with a Conventional 7 L Reactor
Betts, Jonathan Ian; Doig, Steven D.; Baganz, Frank · 2006 · Biotechnology Progress · DOI
Full title: Characterization and Application of a Miniature 10 mL Stirred-Tank Bioreactor, Showing Scale-Down Equivalence with a Conventional 7 L Reactor
Authors: Betts, Jonathan Ian; Doig, Steven D.; Baganz, Frank
Year: 2006
Venue: Biotechnology Progress
Paper Design of a Tubular Loop Bioreactor for Scale‐up and Scale‐down of Fermentation Processes
Papagianni, Maria; Mattey, M.; Kristiansen, Bjørn‐Erik · 2003 · Biotechnology Progress · DOI
Full title: Design of a Tubular Loop Bioreactor for Scale‐up and Scale‐down of Fermentation Processes
Authors: Papagianni, Maria; Mattey, M.; Kristiansen, Bjørn‐Erik
Year: 2003
Venue: Biotechnology Progress
Paper Development of Scale‐Down Techniques for Investigation of Recombinant <i>Escherichia coli</i> Fermentations: Acid Metabolites in Shake Flasks and Stirred Bioreactors
Dahlgren, Mary Ellen; Powell, Alan L.; Greasham, Randolph et al. · 1993 · Biotechnology Progress · DOI
Full title: Development of Scale‐Down Techniques for Investigation of Recombinant <i>Escherichia coli</i> Fermentations: Acid Metabolites in Shake Flasks and Stirred Bioreactors
Authors: Dahlgren, Mary Ellen; Powell, Alan L.; Greasham, Randolph; George, Hugh A.
Year: 1993
Venue: Biotechnology Progress
Paper A methodical approach to ultra-scale-down of process sequences: application to casein removal from the milk of transgenic animals.
Pampel, Lars W; Boushaba, Rihab; Titchener-Hooker, Nigel J · 2008 · Biotechnology progress · DOI
Full title: A methodical approach to ultra-scale-down of process sequences: application to casein removal from the milk of transgenic animals.
Authors: Pampel, Lars W; Boushaba, Rihab; Titchener-Hooker, Nigel J
Year: 2008
Venue: Biotechnology progress
Paper A systematic approach for scale-down model development and characterization of commercial cell culture processes.
Li, Feng; Hashimura, Yasunori; Pendleton, Robert et al. · 2006 · Biotechnology progress · DOI
Full title: A systematic approach for scale-down model development and characterization of commercial cell culture processes.
Authors: Li, Feng; Hashimura, Yasunori; Pendleton, Robert; Harms, Jean; Collins, Erin; Lee, Brian
Year: 2006
Venue: Biotechnology progress
Paper A comprehensive study of glucose and oxygen gradients in a scaled-down model of recombinant HuGM-CSF production in thermoinduced Escherichia coli fed-batch cultures.
Reynoso-Cereceda, Greta I; Valdez-Cruz, Norma A; Pérez, Nestor O et al. · 2024 · Preparative biochemistry & biotechnology · DOI
Full title: A comprehensive study of glucose and oxygen gradients in a scaled-down model of recombinant HuGM-CSF production in thermoinduced Escherichia coli fed-batch cultures.
Authors: Reynoso-Cereceda, Greta I; Valdez-Cruz, Norma A; Pérez, Nestor O; Trujillo-Roldán, Mauricio A
Year: 2024
Venue: Preparative biochemistry & biotechnology
Paper Toward a Stochastic Formulation of Microbial Growth in Relation to Bioreactor Performances: Case Study of an E. coli Fed-Batch Process
Delvigne, Frank; Destain, Jean-Pierre; Thonart, Philippe · 2006 · Biotechnology Progress · DOI
Full title: Toward a Stochastic Formulation of Microbial Growth in Relation to Bioreactor Performances: Case Study of an E. coli Fed-Batch Process
Authors: Delvigne, Frank; Destain, Jean-Pierre; Thonart, Philippe
Year: 2006
Venue: Biotechnology Progress
Paper Upstream cell culture process characterization and in-process control strategy development at pandemic speed.
Xu, Jianlin; Ou, Jianfa; McHugh, Kyle P et al. · 2022 · mAbs · DOI
Full title: Upstream cell culture process characterization and in-process control strategy development at pandemic speed.
Authors: Xu, Jianlin; Ou, Jianfa; McHugh, Kyle P; Borys, Michael C; Khetan, Anurag
Year: 2022
Venue: mAbs
Paper Performing in spite of starvation: How Saccharomyces cerevisiae maintains robust growth when facing famine zones in industrial bioreactors
Minden, Steven; Aniolek, Maria; Noorman, Henk et al. · 2022 · Microbial Biotechnology · DOI
Full title: Performing in spite of starvation: How Saccharomyces cerevisiae maintains robust growth when facing famine zones in industrial bioreactors
Authors: Minden, Steven; Aniolek, Maria; Noorman, Henk; Takors, Ralf
Year: 2022
Venue: Microbial Biotechnology
Paper Biological processing in oscillatory baffled reactors: operation, advantages and potential
Abbott, Matthew S.R.; Harvey, Adam; Perez, Gustavo Valente et al. · 2012 · Interface Focus · DOI
Full title: Biological processing in oscillatory baffled reactors: operation, advantages and potential
Authors: Abbott, Matthew S.R.; Harvey, Adam; Perez, Gustavo Valente; Theodorou, M. K.
Year: 2012
Venue: Interface Focus
Paper Chemical and Biological Sensor Capsules for Real-Time Measurement of Cell Properties in Bioreactors
Jin, Decarle S.; Zhu, Xingyuan; Brightbill, Eleanor L. et al. · 2021 · ECS Meeting Abstracts · DOI
Full title: Chemical and Biological Sensor Capsules for Real-Time Measurement of Cell Properties in Bioreactors
Authors: Jin, Decarle S.; Zhu, Xingyuan; Brightbill, Eleanor L.; Brown, Billyde; Vogel, Eric M.
Year: 2021
Venue: ECS Meeting Abstracts
Paper Bioprocess scale‐up/down as integrative enabling technology: from fluid mechanics to systems biology and beyond
Delvigne, Frank; Takors, Ralf; Mudde, Rob et al. · 2017 · Microbial Biotechnology · DOI
Full title: Bioprocess scale‐up/down as integrative enabling technology: from fluid mechanics to systems biology and beyond
Authors: Delvigne, Frank; Takors, Ralf; Mudde, Rob; Gulik, Walter van; Noorman, Henk
Year: 2017
Venue: Microbial Biotechnology
Paper Genome reduction improves octanoic acid production in scale down bioreactors
Cordell, William T.; Avolio, Gennaro; Takors, Ralf et al. · 2024 · Microbial Biotechnology · DOI
Full title: Genome reduction improves octanoic acid production in scale down bioreactors
Authors: Cordell, William T.; Avolio, Gennaro; Takors, Ralf; Pfleger, Brian F.
Year: 2024
Venue: Microbial Biotechnology
Paper Integrated Robotic Mini Bioreactor Platform for Automated, Parallel Microbial Cultivation With Online Data Handling and Process Control
Haby, Benjamin; Hans, Sebastian; Anane, Emmanuel et al. · 2019 · SLAS TECHNOLOGY · DOI
Full title: Integrated Robotic Mini Bioreactor Platform for Automated, Parallel Microbial Cultivation With Online Data Handling and Process Control
Authors: Haby, Benjamin; Hans, Sebastian; Anane, Emmanuel; Sawatzki, Annina; Krausch, Niels; Neubauer, Peter; Bournazou, Mariano Nicolás Cruz
Year: 2019
Venue: SLAS TECHNOLOGY
Paper Scaling Up and Scaling Down for Cell Culture Bioreactors
Hu, Wei‐Shou · 2020 · DOI
Full title: Scaling Up and Scaling Down for Cell Culture Bioreactors
Authors: Hu, Wei‐Shou
Year: 2020
Paper Scale-Down Effect on Hydrodynamics, Mass Transfer, and Bioconversion in a Multiphase Partitioning Bioreactor
Melgarejo-Torres, Rodrigo; Castillo‐Araiza, Carlos O.; Palmerín-Carreño, Dulce María et al. · 2019 · DOI
Full title: Scale-Down Effect on Hydrodynamics, Mass Transfer, and Bioconversion in a Multiphase Partitioning Bioreactor
Authors: Melgarejo-Torres, Rodrigo; Castillo‐Araiza, Carlos O.; Palmerín-Carreño, Dulce María; Gansbeke, Bart Van; Huerta‐Ochoa, Sergio
Year: 2019
Paper Aeration, Mixing and Hydrodynamics in Bioreactors
Ma, Ningning; Mollet, Mike; Chalmers, Jeffrey J. · 2005 · DOI
Full title: Aeration, Mixing and Hydrodynamics in Bioreactors
Authors: Ma, Ningning; Mollet, Mike; Chalmers, Jeffrey J.
Year: 2005
Paper Development and Qualification of a Scale-Down Mammalian Cell Culture Model and Application in Design Space Development by Definitive Screening Design.
Nie, Lei; Gao, Dong; Jiang, Haiyan et al. · 2019 · AAPS PharmSciTech · DOI
Full title: Development and Qualification of a Scale-Down Mammalian Cell Culture Model and Application in Design Space Development by Definitive Screening Design.
Authors: Nie, Lei; Gao, Dong; Jiang, Haiyan; Gou, Jinxia; Li, Lei; Hu, Feng; Guo, Tingting; Wang, Haibin; Qu, Haibin
Year: 2019
Venue: AAPS PharmSciTech
Paper Real-time monitoring of cell viability and cell density on the basis of a three dimensional optical reflectance method (3D-ORM): investigation of the effect of sub-lethal and lethal injuries.
Brognaux, Alison; Bugge, Jörg; Schwartz, Friedel H et al. · 2013 · Journal of industrial microbiology & biotechnology · DOI
Full title: Real-time monitoring of cell viability and cell density on the basis of a three dimensional optical reflectance method (3D-ORM): investigation of the effect of sub-lethal and lethal injuries.
Authors: Brognaux, Alison; Bugge, Jörg; Schwartz, Friedel H; Thonart, Philippe; Telek, Samuel; Delvigne, Frank
Year: 2013
Venue: Journal of industrial microbiology & biotechnology
Paper Use of near-infrared spectroscopy (NIRs) in the biopharmaceutical industry for real-time determination of critical process parameters and integration of advanced feedback control strategies using MIDUS control
Vann, Lucas; Sheppard, John D. · 2017 · Journal of Industrial Microbiology & Biotechnology · DOI
Full title: Use of near-infrared spectroscopy (NIRs) in the biopharmaceutical industry for real-time determination of critical process parameters and integration of advanced feedback control strategies using MIDUS control
Authors: Vann, Lucas; Sheppard, John D.
Year: 2017
Venue: Journal of Industrial Microbiology & Biotechnology
Paper Scale-down assessment of the sensitivity of <i>Yarrowia lipolytica</i> to oxygen transfer and foam management in bioreactors: investigation of the underlying physiological mechanisms
Kar, Tambi; Destain, Jacqueline; Thonart, Philippe et al. · 2011 · Journal of Industrial Microbiology & Biotechnology · DOI
Full title: Scale-down assessment of the sensitivity of <i>Yarrowia lipolytica</i> to oxygen transfer and foam management in bioreactors: investigation of the underlying physiological mechanisms
Authors: Kar, Tambi; Destain, Jacqueline; Thonart, Philippe; Delvigne, Frank
Year: 2011
Venue: Journal of Industrial Microbiology & Biotechnology
Paper Influence of bioreactor hydraulic characteristics on a Saccharomyces cerevisiae fed-batch culture: hydrodynamic modelling and scale-down investigations
Lejeune, Annick; Delvigne, Frank; Thonart, Philippe · 2009 · Journal of Industrial Microbiology & Biotechnology · DOI
Full title: Influence of bioreactor hydraulic characteristics on a Saccharomyces cerevisiae fed-batch culture: hydrodynamic modelling and scale-down investigations
Authors: Lejeune, Annick; Delvigne, Frank; Thonart, Philippe
Year: 2009
Venue: Journal of Industrial Microbiology & Biotechnology
Paper Pseudorabies virus production using a serum-free medium in fixed-bed bioreactors with low cell inoculum density.
Nie, Jianqi; Sun, Yang; Peng, Feng et al. · 2020 · Biotechnology letters · DOI
Full title: Pseudorabies virus production using a serum-free medium in fixed-bed bioreactors with low cell inoculum density.
Authors: Nie, Jianqi; Sun, Yang; Peng, Feng; Han, Fei; Yang, Yankun; Liu, Xiuxia; Liu, Chunli; Li, Ye; Bai, Zhonghu
Year: 2020
Venue: Biotechnology letters
Paper Establishment and optimization of a high-throughput mimic perfusion model in ambr® 15.
Jin, Lu; Wang, Zhen-Shou; Cao, Yun et al. · 2021 · Biotechnology letters · DOI
Full title: Establishment and optimization of a high-throughput mimic perfusion model in ambr® 15.
Authors: Jin, Lu; Wang, Zhen-Shou; Cao, Yun; Sun, Rui-Qiang; Zhou, Hang; Cao, Rong-Yue
Year: 2021
Venue: Biotechnology letters
Paper Establishment of a semi-continuous scale-down clone screening model for intensified perfusion culture.
Sun, Tao; Zhang, Yu; Liang, Hengrui et al. · 2024 · Biotechnology letters · DOI
Full title: Establishment of a semi-continuous scale-down clone screening model for intensified perfusion culture.
Authors: Sun, Tao; Zhang, Yu; Liang, Hengrui; Fang, Wenjing; Qian, Zichen; Tan, Kee Wee; Li, Junjie; Zheng, Xiang; Fang, Mingyue; Zhou, Hang; Zhou, Weichang; Zhang, Sam
Year: 2024
Venue: Biotechnology letters
Paper Rapid process development of serum-free pseudorabies virus production with the Quality by Design approach.
Nie, Jianqi; Sun, Yang; Han, Fei et al. · 2020 · Cytotechnology · DOI
Full title: Rapid process development of serum-free pseudorabies virus production with the Quality by Design approach.
Authors: Nie, Jianqi; Sun, Yang; Han, Fei; Yang, Yankun; Liu, Xiuxia; Liu, Chunli; Li, Ye; Bai, Zhonghu
Year: 2020
Venue: Cytotechnology
Paper Advanced microscale bioreactor system: a representative scale-down model for bench-top bioreactors.
Hsu, Wei-Ting; Aulakh, Rigzen P S; Traul, Donald L et al. · 2012 · Cytotechnology · DOI
Full title: Advanced microscale bioreactor system: a representative scale-down model for bench-top bioreactors.
Authors: Hsu, Wei-Ting; Aulakh, Rigzen P S; Traul, Donald L; Yuk, Inn H
Year: 2012
Venue: Cytotechnology
Paper Characterization of a monoclonal antibody cell culture production process using a quality by design approach.
Horvath, Brian; Mun, Melissa; Laird, Michael W · 2010 · Molecular biotechnology · DOI
Full title: Characterization of a monoclonal antibody cell culture production process using a quality by design approach.
Authors: Horvath, Brian; Mun, Melissa; Laird, Michael W
Year: 2010
Venue: Molecular biotechnology
Paper Quality by Design characterization of the perfusion culture process for recombinant FVIII.
Yong Jae Kim; S. Paik; S. Han et al. · 2019 · Biologicals (Print) · DOI
Full title: Quality by Design characterization of the perfusion culture process for recombinant FVIII.
Authors: Yong Jae Kim; S. Paik; S. Han; Sunggeun Lee; Yoomin Jeong; Ji-Youn Kim; C. W. Kim
Year: 2019
Venue: Biologicals (Print)
Paper Modelling of industrial-scale bioreactors using the particle lifeline approach
Nadal‐Rey, Gisela; Kavanagh, John M.; Cassells, Benny et al. · 2023 · Biochemical Engineering Journal · DOI
Full title: Modelling of industrial-scale bioreactors using the particle lifeline approach
Authors: Nadal‐Rey, Gisela; Kavanagh, John M.; Cassells, Benny; Cornelissen, Sjef; Fletcher, David F.; Gernaey, Krist V.; McClure, Dale D.
Year: 2023
Venue: Biochemical Engineering Journal
Paper CFD predictive simulations of miniature bioreactor mixing dynamics coupled with photo-bioreaction kinetics in transitional flow regime
Cho, Bovinille Anye; Teke, George M.; Gakingo, Godfrey K. et al. · 2024 · Biochemical Engineering Journal · DOI
Full title: CFD predictive simulations of miniature bioreactor mixing dynamics coupled with photo-bioreaction kinetics in transitional flow regime
Authors: Cho, Bovinille Anye; Teke, George M.; Gakingo, Godfrey K.; Pott, Robert W. M.; Zhang, Dongda
Year: 2024
Venue: Biochemical Engineering Journal
Paper Power, mixing and flow dynamics of the novel Allegro™ stirred tank reactor
Delbridge, J.N.; Barrett, T.A.; Ducci, Andrea et al. · 2023 · Chemical Engineering Science · DOI
Full title: Power, mixing and flow dynamics of the novel Allegro™ stirred tank reactor
Authors: Delbridge, J.N.; Barrett, T.A.; Ducci, Andrea; Micheletti, Martina
Year: 2023
Venue: Chemical Engineering Science
Paper Euler-Lagrange analysis towards representative down-scaling of a 22 m3 aerobic S. cerevisiae fermentation
Haringa, Cees; Deshmukh, Amit T.; Mudde, R.F. et al. · 2017 · Chemical Engineering Science · DOI
Full title: Euler-Lagrange analysis towards representative down-scaling of a 22 m3 aerobic S. cerevisiae fermentation
Authors: Haringa, Cees; Deshmukh, Amit T.; Mudde, R.F.; Noorman, Henk
Year: 2017
Venue: Chemical Engineering Science
Paper Flow-informed clustering of bioreactor volumes to build CFD-based compartment models
Carfort, Johan le Nepvou de; Laborda, Víctor Puig I; Nielsen, Lars K. et al. · 2025 · Chemical Engineering Science · DOI
Full title: Flow-informed clustering of bioreactor volumes to build CFD-based compartment models
Authors: Carfort, Johan le Nepvou de; Laborda, Víctor Puig I; Nielsen, Lars K.; Gernaey, Krist V.; Krühne, Ulrich
Year: 2025
Venue: Chemical Engineering Science
Paper Computational fluid dynamics simulation of an industrial P. chrysogenum fermentation with a coupled 9-pool metabolic model: Towards rational scale-down and design optimization
Haringa, Cees; Tang, Wenjun; Wang, Guan et al. · 2017 · Chemical Engineering Science · DOI
Full title: Computational fluid dynamics simulation of an industrial P. chrysogenum fermentation with a coupled 9-pool metabolic model: Towards rational scale-down and design optimization
Authors: Haringa, Cees; Tang, Wenjun; Wang, Guan; Deshmukh, Amit T.; Winden, Wouter A. van; Chu, Ju; Gulik, Walter M. van; Heijnen, Joseph J.; Mudde, R.F.; Noorman, Henk
Year: 2017
Venue: Chemical Engineering Science
Paper Microfluidic single-cell scale-down systems: introduction, application, and future challenges.
S. Täuber; A. Grünberger · 2023 · Current Opinion in Biotechnology · DOI
Full title: Microfluidic single-cell scale-down systems: introduction, application, and future challenges.
Authors: S. Täuber; A. Grünberger
Year: 2023
Venue: Current Opinion in Biotechnology
Paper Suspension and flow dynamics of the Allegro™ stirred tank reactor
Delbridge, J.N.; Barrett, T.A.; Ducci, Andrea et al. · 2023 · Process Safety and Environmental Protection · DOI
Full title: Suspension and flow dynamics of the Allegro™ stirred tank reactor
Authors: Delbridge, J.N.; Barrett, T.A.; Ducci, Andrea; Micheletti, Martina
Year: 2023
Venue: Process Safety and Environmental Protection
Paper Unsupervised learning bioreactor regimes
Laborda, Víctor Puig I; Puiman, Lars; Groves, Teddy et al. · 2024 · Computers & Chemical Engineering · DOI
Full title: Unsupervised learning bioreactor regimes
Authors: Laborda, Víctor Puig I; Puiman, Lars; Groves, Teddy; Haringa, Cees; Nielsen, Lars K.
Year: 2024
Venue: Computers & Chemical Engineering
Paper Bioprocess microfluidics: applying microfluidic devices for bioprocessing
Marques, Marco P. C.; Szita, Nicolas · 2017 · Current Opinion in Chemical Engineering · DOI
Full title: Bioprocess microfluidics: applying microfluidic devices for bioprocessing
Authors: Marques, Marco P. C.; Szita, Nicolas
Year: 2017
Venue: Current Opinion in Chemical Engineering
Paper Chemical reactor/compounding vessel fingerprinting: Scale-up/down considerations for homogeneous and heterogeneous mixing using computational fluid dynamics
A. Pohar; Omar Naneh; D. Bajec et al. · 2020 · DOI
Full title: Chemical reactor/compounding vessel fingerprinting: Scale-up/down considerations for homogeneous and heterogeneous mixing using computational fluid dynamics
Authors: A. Pohar; Omar Naneh; D. Bajec; B. Likozar
Year: 2020
Paper A novel automated bioreactor for scalable process optimisation of haematopoietic stem cell culture
Ratcliffe, Elizabeth; Glen, Katie; Workman, Victoria L. et al. · 2012 · Journal of Biotechnology · DOI
Full title: A novel automated bioreactor for scalable process optimisation of haematopoietic stem cell culture
Authors: Ratcliffe, Elizabeth; Glen, Katie; Workman, Victoria L.; Stacey, A. J.; Thomas, Robert J.
Year: 2012
Venue: Journal of Biotechnology
Paper Proteomic analysis of micro-scale bioreactors as scale-down model for a mAb producing CHO industrial fed-batch platform.
Bertrand, Vania; Vogg, Sebastian; Villiger, Thomas K et al. · 2018 · Journal of biotechnology · DOI
Full title: Proteomic analysis of micro-scale bioreactors as scale-down model for a mAb producing CHO industrial fed-batch platform.
Authors: Bertrand, Vania; Vogg, Sebastian; Villiger, Thomas K; Stettler, Matthieu; Broly, Hervé; Soos, Miroslav; Morbidelli, Massimo
Year: 2018
Venue: Journal of biotechnology
Paper High-density perfusion cultures of the marine bacterium Rhodovulum sulfidophilum for the biomanufacturing of oligonucleotides.
Iannacci, Francesco; Medeiros Garcia Alcântara, João; Marani, Martina et al. · 2024 · Journal of biotechnology · DOI
Full title: High-density perfusion cultures of the marine bacterium Rhodovulum sulfidophilum for the biomanufacturing of oligonucleotides.
Authors: Iannacci, Francesco; Medeiros Garcia Alcântara, João; Marani, Martina; Camesasca, Paolo; Chen, Michele; Sousa, Fani; Morbidelli, Massimo; Sponchioni, Mattia
Year: 2024
Venue: Journal of biotechnology
Paper Investigation of the physiological response to oxygen limited process conditions of Pichia pastoris Mut(+) strain using a two-compartment scale-down system.
Lorantfy, Bettina; Jazini, Mohammadhadi; Herwig, Christoph · 2013 · Journal of bioscience and bioengineering · DOI
Full title: Investigation of the physiological response to oxygen limited process conditions of Pichia pastoris Mut(+) strain using a two-compartment scale-down system.
Authors: Lorantfy, Bettina; Jazini, Mohammadhadi; Herwig, Christoph
Year: 2013
Venue: Journal of bioscience and bioengineering
Paper An in-silico analysis of hydrodynamics and gas mass transfer characteristics in scale-down models for mammalian cell cultures.
Anand, Alaina; McCahill, Madelynn; Thomas, John et al. · 2024 · Journal of biotechnology · DOI
Full title: An in-silico analysis of hydrodynamics and gas mass transfer characteristics in scale-down models for mammalian cell cultures.
Authors: Anand, Alaina; McCahill, Madelynn; Thomas, John; Sood, Aishwarya; Kinross, Jonathan; Dasgupta, Aparajita; Rajendran, Aravindan
Year: 2024
Venue: Journal of biotechnology
Paper Development of a Scale-Down Model of hydrodynamic stress to study the performance of an industrial CHO cell line under simulated production scale bioreactor conditions.
Sieck, Jochen B; Cordes, Thekla; Budach, Wolfgang E et al. · 2013 · Journal of biotechnology · DOI
Full title: Development of a Scale-Down Model of hydrodynamic stress to study the performance of an industrial CHO cell line under simulated production scale bioreactor conditions.
Authors: Sieck, Jochen B; Cordes, Thekla; Budach, Wolfgang E; Rhiel, Martin H; Suemeghy, Zoltan; Leist, Christian; Villiger, Thomas K; Morbidelli, Massimo; Soos, Miroslav
Year: 2013
Venue: Journal of biotechnology
Paper Development and qualification of a representative scale-down model of automated Ficoll-based processing of a cell-based therapeutic according to quality by design principles.
Sanjuan-Gimenez, Jose Carlos; Morales, Macarena López; Carranza-Garcia, Isabel et al. · 2021 · Cytotherapy · DOI
Full title: Development and qualification of a representative scale-down model of automated Ficoll-based processing of a cell-based therapeutic according to quality by design principles.
Authors: Sanjuan-Gimenez, Jose Carlos; Morales, Macarena López; Carranza-Garcia, Isabel; Pino-Zumaquero, Alberto Del; Hernández-Ruiz, Laura; Villegas, Enrique
Year: 2021
Venue: Cytotherapy
Paper The design and characterisation of miniature bioreactors for microbial fermentation process development
Betts, Jonathan Ian · 2006 · OpenGrey (Institut de l'Information Scientifique et Technique)
Full title: The design and characterisation of miniature bioreactors for microbial fermentation process development
Authors: Betts, Jonathan Ian
Year: 2006
Venue: OpenGrey (Institut de l'Information Scientifique et Technique)
Paper Trehalose as a stress marker of the physiological impact of mixing on yeast production: scale-down reactors and mini-bioreactors investigations
Lejeune, Annick; Delvigne, Frank; Thonart, Philippe · 2010 · SHILAP Revista de lepidopterología
Full title: Trehalose as a stress marker of the physiological impact of mixing on yeast production: scale-down reactors and mini-bioreactors investigations
Authors: Lejeune, Annick; Delvigne, Frank; Thonart, Philippe
Year: 2010
Venue: SHILAP Revista de lepidopterología
Paper Simulating Process Limitations in Microbial Cultivation: A Parallel Two-Compartment Scale-Down Approach
Limberg, Michael; Zelle, Stephan; Schlottbom, Christiane et al. · 2016
Full title: Simulating Process Limitations in Microbial Cultivation: A Parallel Two-Compartment Scale-Down Approach
Authors: Limberg, Michael; Zelle, Stephan; Schlottbom, Christiane; Oldiges, Marco
Year: 2016
Paper Process design and development of a mammalian cell perfusion culture in shake-tube and benchtop bioreactors.
Wolf, Moritz K F; Müller, Andrea; Souquet, Jonathan et al. · 2019 · Biotechnology and bioengineering · DOI
Full title: Process design and development of a mammalian cell perfusion culture in shake-tube and benchtop bioreactors.
Authors: Wolf, Moritz K F; Müller, Andrea; Souquet, Jonathan; Broly, Hervé; Morbidelli, Massimo
Year: 2019
Venue: Biotechnology and bioengineering
Paper Development and qualification of 3 L scale-down model for large scale vaccine process on Vero cell culture using microcarriers.
Huang, Renjing; Wang, Kai; Flamm, Matthew H et al. · 2024 · Biotechnology and bioengineering · DOI
Full title: Development and qualification of 3 L scale-down model for large scale vaccine process on Vero cell culture using microcarriers.
Authors: Huang, Renjing; Wang, Kai; Flamm, Matthew H; Vazquez, Jorge; Gercke, Chris; Ton, Christopher; Whitmer, Travis; Mathis, Pamela K; Ploeger, Kristin J M; Rameez, Shahid
Year: 2024
Venue: Biotechnology and bioengineering
Paper Analysis of Tubespins as a suitable scale-down model of bioreactors for high cell density CHO cell culture.
Gomez, Natalia; Ambhaikar, Malhar; Zhang, Li et al. · 2017 · Biotechnology progress · DOI
Full title: Analysis of Tubespins as a suitable scale-down model of bioreactors for high cell density CHO cell culture.
Authors: Gomez, Natalia; Ambhaikar, Malhar; Zhang, Li; Huang, Chung-Jr; Barkhordarian, Hedieh; Lull, Jonathan; Gutierrez, Chris
Year: 2017
Venue: Biotechnology progress
Paper Development of a miniature bioreactor model to study the impact of pH and DOT fluctuations on CHO cell culture performance as a tool to understanding heterogeneity effects at large‐scale
Zakrzewski, R.; Lee, Kenneth; Lye, Gary J. · 2022 · Biotechnology Progress · DOI
Full title: Development of a miniature bioreactor model to study the impact of pH and DOT fluctuations on CHO cell culture performance as a tool to understanding heterogeneity effects at large‐scale
Authors: Zakrzewski, R.; Lee, Kenneth; Lye, Gary J.
Year: 2022
Venue: Biotechnology Progress
Paper A new microfluidic concept for parallel operated milliliter‐scale stirred tank bioreactors
Gebhardt, Gabi; Hortsch, Ralf; Kaufmann, Klaus et al. · 2011 · Biotechnology Progress · DOI
Full title: A new microfluidic concept for parallel operated milliliter‐scale stirred tank bioreactors
Authors: Gebhardt, Gabi; Hortsch, Ralf; Kaufmann, Klaus; Arnold, Matthias; Weuster‐Botz, Dirk
Year: 2011
Venue: Biotechnology Progress
Paper Investigation of the effect of different extracellular factors on the lipase production by Yarrowia lipolityca on the basis of a scale-down approach
Kar, Tambi; Delvigne, Frank; Masson, Martial et al. · 2008 · Journal of Industrial Microbiology & Biotechnology · DOI
Full title: Investigation of the effect of different extracellular factors on the lipase production by Yarrowia lipolityca on the basis of a scale-down approach
Authors: Kar, Tambi; Delvigne, Frank; Masson, Martial; Destain, Jacqueline; Thonart, Philippe
Year: 2008
Venue: Journal of Industrial Microbiology & Biotechnology
Paper Rapid vaccine development using a micro-scale platform
Mukhopadhyay, Tarit · 2008 · Doctoral thesis, UCL (University College London).
Full title: Rapid vaccine development using a micro-scale platform
Authors: Mukhopadhyay, Tarit
Year: 2008
Venue: Doctoral thesis, UCL (University College London).
Thesis Unsupervised learning bioreactor regimes
Laborda, Víctor Puig I.; Puiman, Lars; Groves, Teddy et al. · 2025 · Technical University of Denmark (DTU) · DOI
Full title: Unsupervised learning bioreactor regimes
Authors: Laborda, Víctor Puig I.; Puiman, Lars; Groves, Teddy; Haringa, Cees; Nielsen, Lars Keld
Year: 2025
Venue: Technical University of Denmark (DTU)
Thesis A new approach for k(L)a determination by gassing-out method in pneumatic bioreactors
Cerri, Marcel Otavio [UNESP]; Esperanca, Mateus Nordi; Badino, Alberto Colli et al. · 2018 · Universidade Estadual Paulista (UNESP) · DOI
Full title: A new approach for k(L)a determination by gassing-out method in pneumatic bioreactors
Authors: Cerri, Marcel Otavio [UNESP]; Esperanca, Mateus Nordi; Badino, Alberto Colli; Arruda Ribeiro, Marcelo Perencin de
Year: 2018
Venue: Universidade Estadual Paulista (UNESP)
Thesis Automated algorithm to determine k(L)a considering system delay
Torres, Paulina; Cerri, Marcel Otavio [UNESP]; Arruda Ribeiro, Marcelo Perencin de et al. · 2018 · Universidade Estadual Paulista (UNESP) · DOI
Full title: Automated algorithm to determine k(L)a considering system delay
Authors: Torres, Paulina; Cerri, Marcel Otavio [UNESP]; Arruda Ribeiro, Marcelo Perencin de; Ricardo Perez-Correa, J.; Agosin, Eduardo
Year: 2018
Venue: Universidade Estadual Paulista (UNESP)
Thesis Aeration step method for k(L)a measurement under growth conditions in pneumatic bioreactors
Mestre, Julia C.; Cerri, Marcel O. [UNESP]; Esperanca, Mateus N. et al. · 2019 · Universidade Estadual Paulista (UNESP) · DOI
Full title: Aeration step method for k(L)a measurement under growth conditions in pneumatic bioreactors
Authors: Mestre, Julia C.; Cerri, Marcel O. [UNESP]; Esperanca, Mateus N.; Pedrolli, Danielle B. [UNESP]; Badino, Alberto C.
Year: 2019
Venue: Universidade Estadual Paulista (UNESP)
Thesis Hydrodynamic comparison of different geometries of square cross-section airlift bioreactor using computational fluid dynamics
Esperança, Mateus N.; Cerri, Marcel O. [UNESP]; Mazziero, Vítor T. [UNESP] et al. · 2025 · Universidade Estadual Paulista (UNESP) · DOI
Full title: Hydrodynamic comparison of different geometries of square cross-section airlift bioreactor using computational fluid dynamics
Authors: Esperança, Mateus N.; Cerri, Marcel O. [UNESP]; Mazziero, Vítor T. [UNESP]; Béttega, Rodrigo; Badino, Alberto C.
Year: 2025
Venue: Universidade Estadual Paulista (UNESP)
Thesis Linking maximal shear rate and energy dissipation/circulation function in airlift bioreactors
Esperança, Mateus N.; Buffo, Mariane M.; Mendes, Caroline E. et al. · 2022 · Universidade Estadual Paulista (UNESP) · DOI
Full title: Linking maximal shear rate and energy dissipation/circulation function in airlift bioreactors
Authors: Esperança, Mateus N.; Buffo, Mariane M.; Mendes, Caroline E.; Rodriguez, Guilherme Y.; Béttega, Rodrigo; Badino, Alberto C.; Cerri, Marcel O. [UNESP]
Year: 2022
Venue: Universidade Estadual Paulista (UNESP)
Thesis DROSOPHILA S2 cell culture in a WAVE Bioreactor: potential for scaling up the production of the recombinant rabies virus glycoprotein
Decarli, Monize Caiado; Santos, Diogo Peres dos; Astray, Renato Mancini et al. · 2018 · Universidade Estadual Paulista (UNESP) · DOI
Full title: DROSOPHILA S2 cell culture in a WAVE Bioreactor: potential for scaling up the production of the recombinant rabies virus glycoprotein
Authors: Decarli, Monize Caiado; Santos, Diogo Peres dos; Astray, Renato Mancini; Ventini-Monteiro, Daniella Cristina; Calil Jorge, Soraia Attie; Correia, Daniela Matilde; Silva, Juliana de Sa da; Rocca, Mayra Pereira [UNESP]; Langoni, Helio [UNESP]; Menozzi, Benedito Donizete [UNESP]; Pereira, Carlos Augusto; Torres Suazo, Claudio Alberto
Year: 2018
Venue: Universidade Estadual Paulista (UNESP)
Thesis Oxygen transfer and gas holdup in airlift bioreactors assembled with helical flow promoters
Picão, Bruno W. [UNESP]; Gonçalves, Daniele O. [UNESP]; Ribeiro, Renata M. M. G. P. et al. · 2023 · Universidade Estadual Paulista (UNESP) · DOI
Full title: Oxygen transfer and gas holdup in airlift bioreactors assembled with helical flow promoters
Authors: Picão, Bruno W. [UNESP]; Gonçalves, Daniele O. [UNESP]; Ribeiro, Renata M. M. G. P.; Esperança, Mateus N.; Peixoto, Guilherme [UNESP]; Cerri, Marcel O. [UNESP]
Year: 2023
Venue: Universidade Estadual Paulista (UNESP)
Thesis CHO cell cultures in shake flasks and bioreactors present different host cell protein profiles in the supernatant
Goey, CH; Bell, D; Kontoravdi, C · 2019 · Imperial College London · DOI
Full title: CHO cell cultures in shake flasks and bioreactors present different host cell protein profiles in the supernatant
Authors: Goey, CH; Bell, D; Kontoravdi, C
Year: 2019
Venue: Imperial College London
Thesis Automated Conditional Screening of Multiple Escherichia coli Strains in Parallel Adaptive Fed-Batch Cultivations
Hans, Sebastian; Haby, Benjamin; Krausch, Niels et al. · 2020 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI
Full title: Automated Conditional Screening of Multiple Escherichia coli Strains in Parallel Adaptive Fed-Batch Cultivations
Authors: Hans, Sebastian; Haby, Benjamin; Krausch, Niels; id_orcid0000-0003-2325-6001; Barz, Tilman; Neubauer, Peter; Cruz Bournazou, Mariano Nicolas; id_orcid0000-0003-2325-6001
Year: 2020
Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)
Thesis Design, characterization and application of the multiple air-lift loop bioreactor
Bakker, W.A.M. · 1995 · Wageningen University & Research · DOI
Full title: Design, characterization and application of the multiple air-lift loop bioreactor
Authors: Bakker, W.A.M.
Year: 1995
Venue: Wageningen University & Research
Thesis IPV v2.0 : upgrading the established inactivated polio vaccine production process
Thomassen, Y.E. · 2014 · Wageningen University & Research · DOI
Full title: IPV v2.0 : upgrading the established inactivated polio vaccine production process
Authors: Thomassen, Y.E.
Year: 2014
Venue: Wageningen University & Research
Thesis Scale-down of CHO cell fed-batch cultures
Pan, Xiao · 2018 · Wageningen University & Research · DOI
Full title: Scale-down of CHO cell fed-batch cultures
Authors: Pan, Xiao
Year: 2018
Venue: Wageningen University & Research
Thesis Acoustic perfusion processes for hybridoma cultures: viability, cell cycle and metabolic analysis
Dalm, M.C.F. · 2007 · Wageningen University & Research · DOI
Full title: Acoustic perfusion processes for hybridoma cultures: viability, cell cycle and metabolic analysis
Authors: Dalm, M.C.F.
Year: 2007
Venue: Wageningen University & Research
Thesis Transcriptomic profiling as a tool to characterize CHO cell processes
Al Sayyari, Abdulaziz Abdullah · 2018 · Wageningen University & Research · DOI
Full title: Transcriptomic profiling as a tool to characterize CHO cell processes
Authors: Al Sayyari, Abdulaziz Abdullah
Year: 2018
Venue: Wageningen University & Research
Thesis On the lattice Boltzmann method simulation of a two-phase flow bioreactor for artificially grown cartilage cells
Hussein, M. A.; Esterl, S.; Pörtner, R. et al. · 2008 · Technical University of Munich (TUM) · DOI
Full title: On the lattice Boltzmann method simulation of a two-phase flow bioreactor for artificially grown cartilage cells
Authors: Hussein, M. A.;Esterl, S.;Pörtner, R.;Wiegandt, K.;Becker, T.
Year: 2008
Venue: Technical University of Munich (TUM)
Thesis Investigation of the effect of uncertain growth kinetics on a CFD based model for the growth of S. cerevisiae in an industrial bioreactor
Wright, Mathias Risager; Bach, Christian; Gernaey, Krist V. et al. · 2018 · Technical University of Denmark (DTU) · DOI
Full title: Investigation of the effect of uncertain growth kinetics on a CFD based model for the growth of S. cerevisiae in an industrial bioreactor
Authors: Wright, Mathias Risager; Bach, Christian; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Krühne, Ulrich; id_orcid 0000-0001-7774-7442
Year: 2018
Venue: Technical University of Denmark (DTU)
Thesis Experimental and in-silico investigation of population heterogeneity in continuous Sachharomyces cerevisiae scale-down fermentation in a novel two-compartment setup.
Heins, Anna-Lena; Lencastre Fernandes, Rita; Gernaey, Krist et al. · 2015 · Technical University of Denmark (DTU) · DOI
Full title: Experimental and in-silico investigation of population heterogeneity in continuous Sachharomyces cerevisiae scale-down fermentation in a novel two-compartment setup.
Authors: Heins, Anna-Lena; Lencastre Fernandes, Rita; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Eliasson Lantz, Anna
Year: 2015
Venue: Technical University of Denmark (DTU)
Thesis Optimising the biosynthesis of oxygenated and acetylated Taxol precursors in Saccharomyces cerevisiae using advanced bioprocessing strategies
Walls, Laura E.; Malci, Koray; Nowrouzi, Behnaz et al. · 2021 · Technical University of Denmark (DTU) · DOI
Full title: Optimising the biosynthesis of oxygenated and acetylated Taxol precursors in Saccharomyces cerevisiae using advanced bioprocessing strategies
Authors: Walls, Laura E.; Malci, Koray; Nowrouzi, Behnaz; Li, Rachel; d'Espaux, Leo; Wong, Jeff; Dennis, Jonathan A.; Semiao, Andrea J C; Wallace, Stephen; Martinez, José L.; id_orcid 0000-0002-4490-8534; Keasling, Jay D.; Rios-Solis, Leonardo
Year: 2021
Venue: Technical University of Denmark (DTU)
Thesis Mechanistic Modelling for Risk-Based Monitoring of Lactic Acid Bacteria Cultivations
Spann, Robert; id_orcid 0000-0003-1223-2805 · 2018 · Technical University of Denmark (DTU) · DOI
Full title: Mechanistic Modelling for Risk-Based Monitoring of Lactic Acid Bacteria Cultivations
Authors: Spann, Robert; id_orcid 0000-0003-1223-2805
Year: 2018
Venue: Technical University of Denmark (DTU)
Thesis Modelling of industrial-scale bioreactors using the particle lifeline approach
Nadal-Rey, Gisela; Kavanagh, John M.; Cassells, Benny et al. · 2023 · Technical University of Denmark (DTU) · DOI
Full title: Modelling of industrial-scale bioreactors using the particle lifeline approach
Authors: Nadal-Rey, Gisela; Kavanagh, John M.; Cassells, Benny; Cornelissen, Sjef; Fletcher, David F.; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; McClure, Dale D.
Year: 2023
Venue: Technical University of Denmark (DTU)
Thesis Hypothesis-driven compartment model for stirred bioreactors utilizing computational fluid dynamics and multiple pH sensors
Nørregaard, Anders; Bach, Christian; Krühne, Ulrich et al. · 2018 · Technical University of Denmark (DTU) · DOI
Full title: Hypothesis-driven compartment model for stirred bioreactors utilizing computational fluid dynamics and multiple pH sensors
Authors: Nørregaard, Anders; Bach, Christian; Krühne, Ulrich; id_orcid 0000-0001-7774-7442; Borbjerg, Ulrik; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773
Year: 2018
Venue: Technical University of Denmark (DTU)
Thesis CFD predicted pH gradients in lactic acid bacteria cultivations
Spann, Robert; id_orcid 0000-0003-1223-2805; Glibstrup, Jens et al. · 2019 · Technical University of Denmark (DTU) · DOI
Full title: CFD predicted pH gradients in lactic acid bacteria cultivations
Authors: Spann, Robert; id_orcid 0000-0003-1223-2805; Glibstrup, Jens; Pellicer-Alborch, Klaus; Junne, Stefan; Neubauer, Peter; Roca, Christophe; Kold, David; Lantz, Anna Eliasson; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Krühne, Ulrich; id_orcid 0000-0001-7774-7442
Year: 2019
Venue: Technical University of Denmark (DTU)
Thesis Strategies and tools to select E. coli fermenterphiles for industrial application
Bafna-Rührer, Jonas; id_orcid 0000-0002-7780-1012 · 2024 · Technical University of Denmark (DTU) · DOI
Full title: Strategies and tools to select E. coli fermenterphiles for industrial application
Authors: Bafna-Rührer, Jonas; id_orcid 0000-0002-7780-1012
Year: 2024
Venue: Technical University of Denmark (DTU)
Thesis Automated compartment model development based on data from flow-following sensor devices
Bisgaard, Jonas; Tajsoleiman, Tannaz; id_orcid 0000-0001-8543-4585 et al. · 2021 · Technical University of Denmark (DTU) · DOI
Full title: Automated compartment model development based on data from flow-following sensor devices
Authors: Bisgaard, Jonas; Tajsoleiman, Tannaz; id_orcid 0000-0001-8543-4585; Muldbak, Monica; id_orcid 0000-0001-6368-3804; Rydal, Thomas; Rasmussen, Tue; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773
Year: 2021
Venue: Technical University of Denmark (DTU)
Thesis Modelling of gradients in industrial aerobic fed-batch fermentation processes
Nadal Rey, Gisela · 2020 · Technical University of Denmark (DTU) · DOI
Full title: Modelling of gradients in industrial aerobic fed-batch fermentation processes
Authors: Nadal Rey, Gisela
Year: 2020
Venue: Technical University of Denmark (DTU)
Thesis An Automatic Method for Generation of CFD-Based 3D Compartment Models: Towards Real-Time Mixing Simulations
Le Nepvou De Carfort, Johan; Pinto, Tiago; Krühne, Ulrich et al. · 2024 · Technical University of Denmark (DTU) · DOI
Full title: An Automatic Method for Generation of CFD-Based 3D Compartment Models: Towards Real-Time Mixing Simulations
Authors: Le Nepvou De Carfort, Johan; Pinto, Tiago; Krühne, Ulrich; id_orcid 0000-0001-7774-7442
Year: 2024
Venue: Technical University of Denmark (DTU)
Thesis A CFD model for determining mixing and mass transfer in a high power agitated bioreactor
Bach, Christian; Albæk, Mads O.; Stocks, Stuart M. et al. · 2016 · Technical University of Denmark (DTU) · DOI
Full title: A CFD model for determining mixing and mass transfer in a high power agitated bioreactor
Authors: Bach, Christian; Albæk, Mads O.; Stocks, Stuart M.; Krühne, Ulrich; id_orcid 0000-0001-7774-7442; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773
Year: 2016
Venue: Technical University of Denmark (DTU)
Thesis Parallel scale-down tool to accelerate fermenterphile selection
Bafna-Rührer, Jonas; id_orcid 0000-0002-7780-1012; Sudarsan, Suresh · 2022 · Technical University of Denmark (DTU) · DOI
Full title: Parallel scale-down tool to accelerate fermenterphile selection
Authors: Bafna-Rührer, Jonas; id_orcid 0000-0002-7780-1012; Sudarsan, Suresh
Year: 2022
Venue: Technical University of Denmark (DTU)
Thesis Computational Fluid Dynamics modelling of hydrodynamics, mixing and oxygen transfer in industrial bioreactors with Newtonian broths
Nadal-Rey, Gisela; McClure, Dale D.; Kavanagh, John M. et al. · 2022 · Technical University of Denmark (DTU) · DOI
Full title: Computational Fluid Dynamics modelling of hydrodynamics, mixing and oxygen transfer in industrial bioreactors with Newtonian broths
Authors: Nadal-Rey, Gisela; McClure, Dale D.; Kavanagh, John M.; Cassells, Benny; Cornelissen, Sjef; Fletcher, David F.; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773
Year: 2022
Venue: Technical University of Denmark (DTU)
Thesis Development and Application of a Novel Free-floating Sensor Device for Bioprocess Optimization
Bisgaard, Jonas · 2021 · Technical University of Denmark (DTU) · DOI
Full title: Development and Application of a Novel Free-floating Sensor Device for Bioprocess Optimization
Authors: Bisgaard, Jonas
Year: 2021
Venue: Technical University of Denmark (DTU)
Thesis Development of dynamic compartment models for industrial aerobic fed-batch fermentation processes
Nadal-Rey, Gisela; McClure, Dale D.; Kavanagh, John M. et al. · 2021 · Technical University of Denmark (DTU) · DOI
Full title: Development of dynamic compartment models for industrial aerobic fed-batch fermentation processes
Authors: Nadal-Rey, Gisela; McClure, Dale D.; Kavanagh, John M.; Cassells, Benny; Cornelissen, Sjef; Fletcher, David F.; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773
Year: 2021
Venue: Technical University of Denmark (DTU)
Thesis Digital models in biotechnology: Towards multi-scale integration and implementation
Hartmann, Fabian S.F.; id_orcid 0000-0001-5394-1865; Udugama, Isuru A. et al. · 2022 · Technical University of Denmark (DTU) · DOI
Full title: Digital models in biotechnology: Towards multi-scale integration and implementation
Authors: Hartmann, Fabian S.F.; id_orcid 0000-0001-5394-1865; Udugama, Isuru A.; Seibold, Gerd M.; id_orcid 0000-0002-9823-8134; Sugiyama, Hirokazu; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773
Year: 2022
Venue: Technical University of Denmark (DTU)
Thesis Dynamic Interplay between O2 Availability, Growth Rates, and the Transcriptome of Yarrowia lipolytica
Kerssemakers, Abraham Antonius Johannes; id_orcid 0000-0002-3462-4642; Øzmerih, Süleyman et al. · 2023 · Technical University of Denmark (DTU) · DOI
Full title: Dynamic Interplay between O2 Availability, Growth Rates, and the Transcriptome of Yarrowia lipolytica
Authors: Kerssemakers, Abraham Antonius Johannes; id_orcid 0000-0002-3462-4642; Øzmerih, Süleyman; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Sudarsan, Suresh
Year: 2023
Venue: Technical University of Denmark (DTU)
Thesis Unsupervised learning bioreactor regimes
Laborda, Víctor Puig I.; Puiman, Lars; Groves, Teddy et al. · 2025 · Technical University of Denmark (DTU) · DOI
Full title: Unsupervised learning bioreactor regimes
Authors: Laborda, Víctor Puig I.; Puiman, Lars; Groves, Teddy; Haringa, Cees; Nielsen, Lars Keld
Year: 2025
Venue: Technical University of Denmark (DTU)
Thesis Flow-informed clustering of bioreactor volumes to build CFD-based compartment models
Le Nepvou De Carfort, Johan; Puig I Laborda, Víctor; Nielsen, Lars Keld et al. · 2025 · Technical University of Denmark (DTU) · DOI
Full title: Flow-informed clustering of bioreactor volumes to build CFD-based compartment models
Authors: Le Nepvou De Carfort, Johan; Puig I Laborda, Víctor; Nielsen, Lars Keld; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Krühne, Ulrich; id_orcid 0000-0001-7774-7442
Year: 2025
Venue: Technical University of Denmark (DTU)
Thesis Challenges in industrial fermentation technology research
Formenti, Luca Riccardo; Nørregaard, Anders; Bolic, Andrijana et al. · 2014 · Technical University of Denmark (DTU) · DOI
Full title: Challenges in industrial fermentation technology research
Authors: Formenti, Luca Riccardo; Nørregaard, Anders; Bolic, Andrijana; Quintanilla Hernandez, Daniela Alejandra; Hagemann, Timo; Larsson, Hilde; Mears, Lisa; Mauricio Iglesias, Miguel; Krühne, Ulrich; id_orcid 0000-0001-7774-7442; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Heins, Anna-Lena
Year: 2014
Venue: Technical University of Denmark (DTU)
Thesis Mechanistic Modelling for Risk-Based Monitoring of Lactic Acid Bacteria Cultivations
Spann, Robert; id_orcid 0000-0003-1223-2805 · 2018 · Technical University of Denmark (DTU) · DOI
Full title: Mechanistic Modelling for Risk-Based Monitoring of Lactic Acid Bacteria Cultivations
Authors: Spann, Robert; id_orcid 0000-0003-1223-2805
Year: 2018
Venue: Technical University of Denmark (DTU)
Thesis Fluid dynamics of a pilot-scale OrbShake bioreactor under different operating conditions
Zhu, Likuan; Zhao, Chunyang; Shiue, Angus et al. · 2021 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Fluid dynamics of a pilot-scale OrbShake bioreactor under different operating conditions
Authors: Zhu, Likuan; Zhao, Chunyang; Shiue, Angus; Jeng, Jyh-Cheng; Wurm, Maria J.; Raussin, Guillaume; Buerki, Cedric-Alain; Wurm, Florian M.
Year: 2021
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis Analysis of volumetric mass transfer coefficient (k(L)a) in small- (250 mL) to large-scale (2500 L) orbitally shaken bioreactors
Zhu, Likuan; Xu, Bin; Wu, Xiaoyu et al. · 2020 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Analysis of volumetric mass transfer coefficient (k(L)a) in small- (250 mL) to large-scale (2500 L) orbitally shaken bioreactors
Authors: Zhu, Likuan; Xu, Bin; Wu, Xiaoyu; Lei, Jianguo; Hacker, David L.; Liang, Xiong; Wurm, Florian M.
Year: 2020
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis Use of Orbital Shaken Disposable Bioreactors for Mammalian Cell Cultures from the Milliliter-Scale to the 1,000-Liter Scale
Zhang, X; Stettler, M; Sanctis, DD et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Use of Orbital Shaken Disposable Bioreactors for Mammalian Cell Cultures from the Milliliter-Scale to the 1,000-Liter Scale
Authors: Zhang, X; Stettler, M; Sanctis, DD; Perrone, M; Parolini, N; Discacciati, M; Jesus, MD; Hacker, D; Quarteroni, A; Wurm, F
Year: 2009
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis Efficient oxygen transfer by surface aeration in shaken cylindrical containers for mammalian cell cultivation at volumetric scales up to 1,000 liters
Zhang, X.; Bürki, C.­A.; Stettler, M. et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Efficient oxygen transfer by surface aeration in shaken cylindrical containers for mammalian cell cultivation at volumetric scales up to 1,000 liters
Authors: Zhang, X.; Bürki, C.­A.; Stettler, M.; De Sanctis, D.; Perrone, M.; Discacciati, M.; Parolini, N.; De Jesus, M.; Hacker, D.L.; Quarteroni, A.; Wurm, F.M.
Year: 2009
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis Development of a predictive model for cell growth in shaken bioreactors as a function of the effects of temperature, oxygen transfer rate and seeding cell concentration
Broccard, Gilles · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Development of a predictive model for cell growth in shaken bioreactors as a function of the effects of temperature, oxygen transfer rate and seeding cell concentration
Authors: Broccard, Gilles
Year: 2009
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis Orbitally shaken bioreactors for mammalian cell culture : engineering characterization and bioprocess scale-up
Zhang, Xiaowei · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Orbitally shaken bioreactors for mammalian cell culture : engineering characterization and bioprocess scale-up
Authors: Zhang, Xiaowei
Year: 2009
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis Determination of a scale-up factor from mixing time studies in orbitally shaken bioreactors
Tissot, Stéphanie; Farhat, Mohamed; Hacker, David L. et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Determination of a scale-up factor from mixing time studies in orbitally shaken bioreactors
Authors: Tissot, Stéphanie; Farhat, Mohamed; Hacker, David L.; Anderlei, Tibor; Kühner, Markus; Comninellis, Christos; Wurm, Florian
Year: 2010
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis Shaken helical track bioreactors: Providing oxygen to high-density cultures of mammalian cells at volumes up to 1000L by surface aeration with air
Zhang, X.; Stettler, M.; Reif, O. et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Shaken helical track bioreactors: Providing oxygen to high-density cultures of mammalian cells at volumes up to 1000L by surface aeration with air
Authors: Zhang, X.; Stettler, M.; Reif, O.; Kocourek, A.; Dejesus, M.; Hacker, D.; Wurm, F.
Year: 2009
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis k(L)a as a predictor for successful probe-independent mammalian cell bioprocesses in orbitally shaken bioreactors
Tissot, Stéphanie; Michel, Patrik O.; Hacker, David L. et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: k(L)a as a predictor for successful probe-independent mammalian cell bioprocesses in orbitally shaken bioreactors
Authors: Tissot, Stéphanie; Michel, Patrik O.; Hacker, David L.; Baldi, Lucia; Jesus, Maria De; Wurm, Florian M.
Year: 2012
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis Novel orbital shake bioreactors for transient production of CHO derived IgGs
Stettler, Matthieu; Zhang, Xiaowei; Hacker, David L. et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Novel orbital shake bioreactors for transient production of CHO derived IgGs
Authors: Stettler, Matthieu; Zhang, Xiaowei; Hacker, David L.; De Jesus, Maria; Wurm, Florian M.
Year: 2012
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis Power input correlation to characterize the hydrodynamics of cylindrical orbitally shaken bioreactors
Klöckner, Wolf; Tissot, Stéphanie; Wurm, Florian et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Power input correlation to characterize the hydrodynamics of cylindrical orbitally shaken bioreactors
Authors: Klöckner, Wolf; Tissot, Stéphanie; Wurm, Florian; Büchs, Jochen
Year: 2012
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis Disposable 600-mL orbitally shaken bioreactor for mammalian cell cultivation in suspension
Monteil, Dominique T.; Tontodonati, Giulia; Ghimire, Saroj et al. · 2013 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Disposable 600-mL orbitally shaken bioreactor for mammalian cell cultivation in suspension
Authors: Monteil, Dominique T.; Tontodonati, Giulia; Ghimire, Saroj; Baldi, Lucia; Hacker, David L.; Bürki, Cédric A.; Wurm, Florian M.
Year: 2013
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis A comparison of orbitally-shaken and stirred-tank bioreactors: pH modulation and bioreactor type affect CHO cell growth and protein glycosylation
Monteil, Dominique T.; Juvet, Valentin; Paz, Jonathan et al. · 2017 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: A comparison of orbitally-shaken and stirred-tank bioreactors: pH modulation and bioreactor type affect CHO cell growth and protein glycosylation
Authors: Monteil, Dominique T.; Juvet, Valentin; Paz, Jonathan; Moniatte, Marc; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.
Year: 2017
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis The Engineering of a Scalable Disposable Orbitally Shaken Bioreactor System for Animal Cell Cultivation and Therapeutic Protein Production
Monteil Jr, Dominique Terry · 2014 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: The Engineering of a Scalable Disposable Orbitally Shaken Bioreactor System for Animal Cell Cultivation and Therapeutic Protein Production
Authors: Monteil Jr, Dominique Terry
Year: 2014
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis Studies on fluid dynamics of the flow field and gas transfer in orbitally shaken tubes
Zhu, Li-Kuan; Song, Bo-Yan; Wang, Zhen-Long et al. · 2017 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Studies on fluid dynamics of the flow field and gas transfer in orbitally shaken tubes
Authors: Zhu, Li-Kuan; Song, Bo-Yan; Wang, Zhen-Long; Monteil, Dominique T.; Shen, Xiao; Hacker, David L.; De Jesus, Maria; Wurm, Florian M.
Year: 2017
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis Fluid dynamics of flow fields in a disposable 600-mL orbitally shaken bioreactor
Zhu, Likuan; Monteil, Dominique T.; Wang, Yukui et al. · 2018 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Fluid dynamics of flow fields in a disposable 600-mL orbitally shaken bioreactor
Authors: Zhu, Likuan; Monteil, Dominique T.; Wang, Yukui; Song, Boyan; Hacker, David L.; Wurm, Maria J.; Li, Xiaobin; Wang, Zhenlong; Wurm, Florian M.
Year: 2018
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis A new method for on-line measurement of the volumetric oxygen uptake rate in membrane aerated animal cell cultures
Ducommun, P.; Ruffieux, P. A.; Furter, M. P. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: A new method for on-line measurement of the volumetric oxygen uptake rate in membrane aerated animal cell cultures
Authors: Ducommun, P.; Ruffieux, P. A.; Furter, M. P.; Marison, I.; von Stockar, U.
Year: 2006
Venue: École polytechnique fédérale de Lausanne (EPFL)
Thesis Optimising the biosynthesis of oxygenated and acetylated Taxol precursors in Saccharomyces cerevisiae using advanced bioprocessing strategies
Walls, Laura E.; Malci, Koray; Nowrouzi, Behnaz et al. · 2021 · Technical University of Denmark (DTU) · DOI
Full title: Optimising the biosynthesis of oxygenated and acetylated Taxol precursors in Saccharomyces cerevisiae using advanced bioprocessing strategies
Authors: Walls, Laura E.; Malci, Koray; Nowrouzi, Behnaz; Li, Rachel; d'Espaux, Leo; Wong, Jeff; Dennis, Jonathan A.; Semiao, Andrea J C; Wallace, Stephen; Martinez, José L.; id_orcid 0000-0002-4490-8534; Keasling, Jay D.; Rios-Solis, Leonardo
Year: 2021
Venue: Technical University of Denmark (DTU)
Thesis Experimental and in-silico investigation of population heterogeneity in continuous Sachharomyces cerevisiae scale-down fermentation in a novel two-compartment setup.
Heins, Anna-Lena; Lencastre Fernandes, Rita; Gernaey, Krist et al. · 2015 · Technical University of Denmark (DTU) · DOI
Full title: Experimental and in-silico investigation of population heterogeneity in continuous Sachharomyces cerevisiae scale-down fermentation in a novel two-compartment setup.
Authors: Heins, Anna-Lena; Lencastre Fernandes, Rita; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Eliasson Lantz, Anna
Year: 2015
Venue: Technical University of Denmark (DTU)
Thesis Sensor equipment for quantification of spatial heterogeneity in large bioreactor
Nørregaard, Anders; Formenti, Luca Riccardo; Stocks, Stuart M. et al. · 2014 · Technical University of Denmark (DTU) · DOI
Full title: Sensor equipment for quantification of spatial heterogeneity in large bioreactor
Authors: Nørregaard, Anders; Formenti, Luca Riccardo; Stocks, Stuart M.; Madsen, Brian; Woodley, John; id_orcid 0000-0002-7976-2483; Gernaey, Krist; id_orcid 0000-0002-0364-1773
Year: 2014
Venue: Technical University of Denmark (DTU)
Thesis An Industrial Perspective on Scale-Down Challenges Using Miniaturized Bioreactors
Tajsoleiman, Tannaz; id_orcid 0000-0001-8543-4585; Mears, Lisa et al. · 2019 · Technical University of Denmark (DTU) · DOI
Full title: An Industrial Perspective on Scale-Down Challenges Using Miniaturized Bioreactors
Authors: Tajsoleiman, Tannaz; id_orcid 0000-0001-8543-4585; Mears, Lisa; Krühne, Ulrich; id_orcid 0000-0001-7774-7442; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Cornelissen, Sjef
Year: 2019
Venue: Technical University of Denmark (DTU)
Thesis Hypothesis-driven compartment model for stirred bioreactors utilizing computational fluid dynamics and multiple pH sensors
Nørregaard, Anders; Bach, Christian; Krühne, Ulrich et al. · 2018 · Technical University of Denmark (DTU) · DOI
Full title: Hypothesis-driven compartment model for stirred bioreactors utilizing computational fluid dynamics and multiple pH sensors
Authors: Nørregaard, Anders; Bach, Christian; Krühne, Ulrich; id_orcid 0000-0001-7774-7442; Borbjerg, Ulrik; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773
Year: 2018
Venue: Technical University of Denmark (DTU)
Thesis A Well-mixed, Polymer-based Microbioreactor with Integrated Optical Measurements
Zhang, Z.; Szita, Nicolas; Boccazzi, P. et al. · 2005 · Technical University of Denmark (DTU) · DOI
Full title: A Well-mixed, Polymer-based Microbioreactor with Integrated Optical Measurements
Authors: Zhang, Z.; Szita, Nicolas; Boccazzi, P.; Sinskey, A.J.; Jensen, K.F.
Year: 2005
Venue: Technical University of Denmark (DTU)
Thesis Modelling of industrial-scale bioreactors using the particle lifeline approach
Nadal-Rey, Gisela; Kavanagh, John M.; Cassells, Benny et al. · 2023 · Technical University of Denmark (DTU) · DOI
Full title: Modelling of industrial-scale bioreactors using the particle lifeline approach
Authors: Nadal-Rey, Gisela; Kavanagh, John M.; Cassells, Benny; Cornelissen, Sjef; Fletcher, David F.; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; McClure, Dale D.
Year: 2023
Venue: Technical University of Denmark (DTU)
Thesis Automated compartment model development based on data from flow-following sensor devices
Bisgaard, Jonas; Tajsoleiman, Tannaz; id_orcid 0000-0001-8543-4585 et al. · 2021 · Technical University of Denmark (DTU) · DOI
Full title: Automated compartment model development based on data from flow-following sensor devices
Authors: Bisgaard, Jonas; Tajsoleiman, Tannaz; id_orcid 0000-0001-8543-4585; Muldbak, Monica; id_orcid 0000-0001-6368-3804; Rydal, Thomas; Rasmussen, Tue; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773
Year: 2021
Venue: Technical University of Denmark (DTU)
Thesis CFD predicted pH gradients in lactic acid bacteria cultivations
Spann, Robert; id_orcid 0000-0003-1223-2805; Glibstrup, Jens et al. · 2019 · Technical University of Denmark (DTU) · DOI
Full title: CFD predicted pH gradients in lactic acid bacteria cultivations
Authors: Spann, Robert; id_orcid 0000-0003-1223-2805; Glibstrup, Jens; Pellicer-Alborch, Klaus; Junne, Stefan; Neubauer, Peter; Roca, Christophe; Kold, David; Lantz, Anna Eliasson; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Krühne, Ulrich; id_orcid 0000-0001-7774-7442
Year: 2019
Venue: Technical University of Denmark (DTU)
Thesis Strategies and tools to select E. coli fermenterphiles for industrial application
Bafna-Rührer, Jonas; id_orcid 0000-0002-7780-1012 · 2024 · Technical University of Denmark (DTU) · DOI
Full title: Strategies and tools to select E. coli fermenterphiles for industrial application
Authors: Bafna-Rührer, Jonas; id_orcid 0000-0002-7780-1012
Year: 2024
Venue: Technical University of Denmark (DTU)
Thesis A CFD model for determining mixing and mass transfer in a high power agitated bioreactor
Bach, Christian; Albæk, Mads O.; Stocks, Stuart M. et al. · 2016 · Technical University of Denmark (DTU) · DOI
Full title: A CFD model for determining mixing and mass transfer in a high power agitated bioreactor
Authors: Bach, Christian; Albæk, Mads O.; Stocks, Stuart M.; Krühne, Ulrich; id_orcid 0000-0001-7774-7442; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773
Year: 2016
Venue: Technical University of Denmark (DTU)
Thesis Evaluation of mixing and mass transfer in a stirred pilot scale bioreactor utilizing CFD
Bach, Christian; Yang, Jifeng; Larsson, Hilde Kristina et al. · 2017 · Technical University of Denmark (DTU) · DOI
Full title: Evaluation of mixing and mass transfer in a stirred pilot scale bioreactor utilizing CFD
Authors: Bach, Christian; Yang, Jifeng; Larsson, Hilde Kristina; Stocks, Stuart M.; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Albæk, Mads Orla; Krühne, Ulrich; id_orcid 0000-0001-7774-7442
Year: 2017
Venue: Technical University of Denmark (DTU)
Thesis Parallel scale-down tool to accelerate fermenterphile selection
Bafna-Rührer, Jonas; id_orcid 0000-0002-7780-1012; Sudarsan, Suresh · 2022 · Technical University of Denmark (DTU) · DOI
Full title: Parallel scale-down tool to accelerate fermenterphile selection
Authors: Bafna-Rührer, Jonas; id_orcid 0000-0002-7780-1012; Sudarsan, Suresh
Year: 2022
Venue: Technical University of Denmark (DTU)
Thesis Design and Application of an Electrochemical Sensor for Ammonium Monitoring in Bioprocesses
Hasanzadeh, Aliyeh; id_orcid 0000-0001-7505-7317; Junicke, Helena et al. · 2020 · Technical University of Denmark (DTU) · DOI
Full title: Design and Application of an Electrochemical Sensor for Ammonium Monitoring in Bioprocesses
Authors: Hasanzadeh, Aliyeh; id_orcid 0000-0001-7505-7317; Junicke, Helena; id_orcid 0000-0002-2513-2486; Dimaki, Maria; id_orcid 0000-0001-5037-2388; Semenova, Daria; Kilstrup, Mogens; id_orcid 0000-0002-3900-723X; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773
Year: 2020
Venue: Technical University of Denmark (DTU)
Thesis Towards a single empirical correlation to predict kLa across scales and processes
Quintanilla Hernandez, Daniela Alejandra; Gernaey, Krist; id_orcid 0000-0002-0364-1773 et al. · 2014 · Technical University of Denmark (DTU) · DOI
Full title: Towards a single empirical correlation to predict kLa across scales and processes
Authors: Quintanilla Hernandez, Daniela Alejandra; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Albæk, Mads O.; Stocks, Stuart M.
Year: 2014
Venue: Technical University of Denmark (DTU)
Thesis Development and Application of a Novel Free-floating Sensor Device for Bioprocess Optimization
Bisgaard, Jonas · 2021 · Technical University of Denmark (DTU) · DOI
Full title: Development and Application of a Novel Free-floating Sensor Device for Bioprocess Optimization
Authors: Bisgaard, Jonas
Year: 2021
Venue: Technical University of Denmark (DTU)
Thesis Computational Fluid Dynamics modelling of hydrodynamics, mixing and oxygen transfer in industrial bioreactors with Newtonian broths
Nadal-Rey, Gisela; McClure, Dale D.; Kavanagh, John M. et al. · 2022 · Technical University of Denmark (DTU) · DOI
Full title: Computational Fluid Dynamics modelling of hydrodynamics, mixing and oxygen transfer in industrial bioreactors with Newtonian broths
Authors: Nadal-Rey, Gisela; McClure, Dale D.; Kavanagh, John M.; Cassells, Benny; Cornelissen, Sjef; Fletcher, David F.; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773
Year: 2022
Venue: Technical University of Denmark (DTU)
Thesis A novel scale-down mimic of perfusion cell culture using sedimentation in an automated microbioreactor (SAM)
Kreye, Steffen; Stahn, Rainer; Nawrath, Karina et al. · 2019 · Technical University of Denmark (DTU) · DOI
Full title: A novel scale-down mimic of perfusion cell culture using sedimentation in an automated microbioreactor (SAM)
Authors: Kreye, Steffen; Stahn, Rainer; Nawrath, Karina; Goralczyk, Vicky; Zoro, Barney; Goletz, Steffen; id_orcid 0000-0003-1463-5448
Year: 2019
Venue: Technical University of Denmark (DTU)
Thesis Scale-down of continuous protein producing Saccharomyces cerevisiae cultivations using a two compartment system
Wright, Naia Risager; Rønnest, Nanna Petersen; Thykær, Jette · 2016 · Technical University of Denmark (DTU) · DOI
Full title: Scale-down of continuous protein producing Saccharomyces cerevisiae cultivations using a two compartment system
Authors: Wright, Naia Risager; Rønnest, Nanna Petersen; Thykær, Jette
Year: 2016
Venue: Technical University of Denmark (DTU)
Thesis Development of dynamic compartment models for industrial aerobic fed-batch fermentation processes
Nadal-Rey, Gisela; McClure, Dale D.; Kavanagh, John M. et al. · 2021 · Technical University of Denmark (DTU) · DOI
Full title: Development of dynamic compartment models for industrial aerobic fed-batch fermentation processes
Authors: Nadal-Rey, Gisela; McClure, Dale D.; Kavanagh, John M.; Cassells, Benny; Cornelissen, Sjef; Fletcher, David F.; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773
Year: 2021
Venue: Technical University of Denmark (DTU)
Thesis A CFD based automatic method for compartment model development
Tajsoleiman, Tannaz; id_orcid 0000-0001-8543-4585; Spann, Robert et al. · 2019 · Technical University of Denmark (DTU) · DOI
Full title: A CFD based automatic method for compartment model development
Authors: Tajsoleiman, Tannaz; id_orcid 0000-0001-8543-4585; Spann, Robert; id_orcid 0000-0003-1223-2805; Bach, Christian; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Huusom, Jakob Kjøbsted; id_orcid 0000-0002-1367-7235; Krühne, Ulrich; id_orcid 0000-0001-7774-7442
Year: 2019
Venue: Technical University of Denmark (DTU)
Thesis Dynamic Interplay between O2 Availability, Growth Rates, and the Transcriptome of Yarrowia lipolytica
Kerssemakers, Abraham Antonius Johannes; id_orcid 0000-0002-3462-4642; Øzmerih, Süleyman et al. · 2023 · Technical University of Denmark (DTU) · DOI
Full title: Dynamic Interplay between O2 Availability, Growth Rates, and the Transcriptome of Yarrowia lipolytica
Authors: Kerssemakers, Abraham Antonius Johannes; id_orcid 0000-0002-3462-4642; Øzmerih, Süleyman; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Sudarsan, Suresh
Year: 2023
Venue: Technical University of Denmark (DTU)
Thesis A flexible well-mixed milliliter-scale reactor with high oxygen transfer rate for microbial cultivations
Bolic, Andrijana; Larsson, Hilde Kristina; Hugelier, Siewert et al. · 2016 · Technical University of Denmark (DTU) · DOI
Full title: A flexible well-mixed milliliter-scale reactor with high oxygen transfer rate for microbial cultivations
Authors: Bolic, Andrijana; Larsson, Hilde Kristina; Hugelier, Siewert; Eliasson Lantz, Anna; Krühne, Ulrich; id_orcid 0000-0001-7774-7442; Gernaey, Krist; id_orcid 0000-0002-0364-1773
Year: 2016
Venue: Technical University of Denmark (DTU)
Thesis Flow-informed clustering of bioreactor volumes to build CFD-based compartment models
Le Nepvou De Carfort, Johan; Puig I Laborda, Víctor; Nielsen, Lars Keld et al. · 2025 · Technical University of Denmark (DTU) · DOI
Full title: Flow-informed clustering of bioreactor volumes to build CFD-based compartment models
Authors: Le Nepvou De Carfort, Johan; Puig I Laborda, Víctor; Nielsen, Lars Keld; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Krühne, Ulrich; id_orcid 0000-0001-7774-7442
Year: 2025
Venue: Technical University of Denmark (DTU)
Thesis Gradient simulation experiments for targeting population heterogeneity in continuous Saccharomyces cerevisiae fermentation
Heins, Anna-Lena; Lencastre Fernandes, Rita; Lundin, L. et al. · 2011 · Technical University of Denmark (DTU) · DOI
Full title: Gradient simulation experiments for targeting population heterogeneity in continuous Saccharomyces cerevisiae fermentation
Authors: Heins, Anna-Lena; Lencastre Fernandes, Rita; Lundin, L.; Carlquist, M.; Sörensen, S.; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Eliasson Lantz, Anna
Year: 2011
Venue: Technical University of Denmark (DTU)
Thesis Efficient and reproducible mammalian cell bioprocesses without probes and controllers?
Tissot, Stéphanie; Oberbek, Agata; Reclari, Martino et al. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Efficient and reproducible mammalian cell bioprocesses without probes and controllers?
Authors: Tissot, Stéphanie; Oberbek, Agata; Reclari, Martino; Dreyer, Matthieu; Hacker, David L.; Baldi, Lucia; Farhat, Mohamed; Wurm, Florian Maria
Year: 2011
Venue: École polytechnique fédérale de Lausanne (EPFL)
Patent us-2009187009-a1
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Full title: us-2009187009-a1
Year: 2009
Patent us-2008311614-a1
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Full title: us-2008311614-a1
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Patent us-2010190245-a1
· 2010
Full title: us-2010190245-a1
Year: 2010
Patent us-2011207165-a1
· 2011
Full title: us-2011207165-a1
Year: 2011
Patent us-2016108112-a1
· 2016
Full title: us-2016108112-a1
Year: 2016
Patent us-2016281044-a1
· 2016
Full title: us-2016281044-a1
Year: 2016
Patent us-2020172606-a1
· 2020
Full title: us-2020172606-a1
Year: 2020
Patent us-8889372-b2
· 2014
Full title: us-8889372-b2
Year: 2014
Patent us-9512392-b2
· 2016
Full title: us-9512392-b2
Year: 2016
Patent us-10544209-b2
· 2020
Full title: us-10544209-b2
Year: 2020
Patent us-11104726-b2
· 2021
Full title: us-11104726-b2
Year: 2021
Patent us-2006024751-a1
· 2006
Full title: us-2006024751-a1
Year: 2006

2. Data Extraction

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Paper
The role of Raman spectroscopy in biopharmaceuticals from development to manufacturing
Esmonde‐White, Karen A.; Cuellar, Maryann; Lewis, Ian R. · 2021
Full title: The role of Raman spectroscopy in biopharmaceuticals from development to manufacturing
Authors: Esmonde‐White, Karen A.; Cuellar, Maryann; Lewis, Ian R.
Paper
Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors
Metze, Sabrina; Ruhl, S. F.; Greller, Gerhard et al. · 2019
Full title: Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors
Authors: Metze, Sabrina; Ruhl, S. F.; Greller, Gerhard; Grimm, C.; Scholz, Judith
Paper
Automated Conditional Screening of Escherichia Coli Knockout Mutants in Parallel Adaptive Fed-Batch Cultivations
Hans, Sebastian; Haby, Benjamin; Krausch, Niels et al. · 2020
Full title: Automated Conditional Screening of Escherichia Coli Knockout Mutants in Parallel Adaptive Fed-Batch Cultivations
Authors: Hans, Sebastian; Haby, Benjamin; Krausch, Niels; Barz, Tilman; Neubauer, Peter; Bournazou, Mariano Nicolás Cruz
Paper
Glucose-Limited Fed-Batch Cultivation Strategy to Mimic Large-Scale Effects in Escherichia coli Linked to Accumulation of Non-Canonical Branched-Chain Amino Acids by Combination of Pyruvate Pulses and Dissolved Oxygen Limitation.
García, Ángel Córcoles; Hauptmann, Peter; Neubauer, Peter · 2021
Full title: Glucose-Limited Fed-Batch Cultivation Strategy to Mimic Large-Scale Effects in Escherichia coli Linked to Accumulation of Non-Canonical Branched-Chain Amino Acids by Combination of Pyruvate Pulses and Dissolved Oxygen Limitation.
Authors: García, Ángel Córcoles; Hauptmann, Peter; Neubauer, Peter
Paper
Методические подходы к валидации технологических процессов получения терапевтических рекомбинатных белков на основе концепции «Quality by Design»
Н. В. Стратонова; Александр Сергеевич Лисов; Алексей Николаевич Морозов et al. · 2018
Full title: Методические подходы к валидации технологических процессов получения терапевтических рекомбинатных белков на основе концепции «Quality by Design»
Authors: Н. В. Стратонова; Александр Сергеевич Лисов; Алексей Николаевич Морозов; Д. В. Тюпа; Р. А. Хамитов
Paper
Optimization of an Industrial Aerobic Bioreactor Using Combined CFD, Scale-Down, and Experimental Techniques
Esmaeilnejad-Ahranjani, Parvaneh; Noofeli, Mojtaba; Faramarzi, Ardeshir · 2022
Full title: Optimization of an Industrial Aerobic Bioreactor Using Combined CFD, Scale-Down, and Experimental Techniques
Authors: Esmaeilnejad-Ahranjani, Parvaneh; Noofeli, Mojtaba; Faramarzi, Ardeshir
Paper
Cell clone selection—impact of operation modes and medium exchange strategies on clone ranking
Dorn, Marie; Ferng, Christine; Klottrup‐Rees, Kerensa et al. · 2025
Full title: Cell clone selection—impact of operation modes and medium exchange strategies on clone ranking
Authors: Dorn, Marie; Ferng, Christine; Klottrup‐Rees, Kerensa; Lee, Kenneth; Micheletti, Martina
Paper
CFD supported scale up of perfusion bioreactors in biopharma
M. Kuschel; J. Wutz; Mustafa Salli et al. · 2023
Full title: CFD supported scale up of perfusion bioreactors in biopharma
Authors: M. Kuschel; J. Wutz; Mustafa Salli; D. Monteil; T. Wucherpfennig
Paper
Scalable CAR-T production in a 2-litre perfusion stirred-tank bioreactor with automated harvesting and scale-down model characterisation.
Springuel, Pierre; Silva Couto, Pedro; Stibbs, Dale J et al. · 2025
Full title: Scalable CAR-T production in a 2-litre perfusion stirred-tank bioreactor with automated harvesting and scale-down model characterisation.
Authors: Springuel, Pierre; Silva Couto, Pedro; Stibbs, Dale J; Szelwicki, Michal; Frangleton, Amanda; Schmidberger, Timo; George, Ajith; Slingsby, Fern; Bevan, Nicola; Ahmad, Asma; Legmann, Rachel; Dianat, Noushin; Ladi, Rukmini; Hengst, Julia; Rafiq, Qasim A
Paper
Small-Scale Fluidized Bed Bioreactor for Long-Term Dynamic Culture of 3D Cell Constructs and in vitro Testing.
Mendonça da Silva, Joana; Erro, Eloy; Awan, Maooz et al. · 2020
Full title: Small-Scale Fluidized Bed Bioreactor for Long-Term Dynamic Culture of 3D Cell Constructs and in vitro Testing.
Authors: Mendonça da Silva, Joana; Erro, Eloy; Awan, Maooz; Chalmers, Sherri-Ann; Fuller, Barry; Selden, Clare
Paper
Growth and eGFP Production of CHO-K1 Suspension Cells Cultivated From Single Cell to Laboratory Scale
Schmitz, Julian; Hertel, Oliver; Yermakov, Boris et al. · 2021
Full title: Growth and eGFP Production of CHO-K1 Suspension Cells Cultivated From Single Cell to Laboratory Scale
Authors: Schmitz, Julian; Hertel, Oliver; Yermakov, Boris; Noll, Thomas; Grünberger, Alexander
Paper
Development of 10 L mass culture system of human induced pluripotent stem cells with intermittent agitation using plastic fluid.
Tokura, Tomohiro; Yamamoto, Riku; Kino-Oka, Masahiro · 2025
Full title: Development of 10 L mass culture system of human induced pluripotent stem cells with intermittent agitation using plastic fluid.
Authors: Tokura, Tomohiro; Yamamoto, Riku; Kino-Oka, Masahiro
Paper
Putting the Spotlight Back on Plant Suspension Cultures
Santos, Rita B.; Abranches, Rita; Fischer, Rainer et al. · 2016
Full title: Putting the Spotlight Back on Plant Suspension Cultures
Authors: Santos, Rita B.; Abranches, Rita; Fischer, Rainer; Sack, M.; Holland, Tanja
Paper
Miniaturization and 3D Printing of Bioreactors: A Technological Mini Review
Achinas, Spyridon; Heins, Jorn‐Ids; Krooneman, Janneke et al. · 2020
Full title: Miniaturization and 3D Printing of Bioreactors: A Technological Mini Review
Authors: Achinas, Spyridon; Heins, Jorn‐Ids; Krooneman, Janneke; Euverink, Gerrit Jan Willem
Paper
Seed Train Optimization in Microcarrier-Based Cell Culture Post In Situ Cell Detachment through Scale-Down Hybrid Modeling
Ebrahimian, Atefeh; Schalk, Mona; Dürkop, Mark et al. · 2024
Full title: Seed Train Optimization in Microcarrier-Based Cell Culture Post In Situ Cell Detachment through Scale-Down Hybrid Modeling
Authors: Ebrahimian, Atefeh; Schalk, Mona; Dürkop, Mark; Maurer, Michael; Bliem, Rudolf; Kühnel, Harald
Paper
Monitoring of the Single-Cell Behavior of an Escherichia coli Reporter Strain Producing L-phenylalanine in a Scale-Down Bioreactor by Automated Real-Time Flow Cytometry.
Arulrajah, Prasika; Riessner, Sophi Katharina; Heins, Anna-Lena et al. · 2025
Full title: Monitoring of the Single-Cell Behavior of an Escherichia coli Reporter Strain Producing L-phenylalanine in a Scale-Down Bioreactor by Automated Real-Time Flow Cytometry.
Authors: Arulrajah, Prasika; Riessner, Sophi Katharina; Heins, Anna-Lena; Weuster-Botz, Dirk
Paper
Bioprocess Design Considerations for Cultured Meat Production With a Focus on the Expansion Bioreactor
Allan, Scott J.; Bank, Paul De; Ellis, Marianne J. · 2019
Full title: Bioprocess Design Considerations for Cultured Meat Production With a Focus on the Expansion Bioreactor
Authors: Allan, Scott J.; Bank, Paul De; Ellis, Marianne J.
Paper
Optimization and Scale-Up of Fermentation Processes Driven by Models
Du, Yuan‐Hang; Wang, Min-Yu; Yang, Linhui et al. · 2022
Full title: Optimization and Scale-Up of Fermentation Processes Driven by Models
Authors: Du, Yuan‐Hang; Wang, Min-Yu; Yang, Linhui; Tong, Lingling; Guo, Dong‐Sheng; Ji, Xiao‐Jun
Paper
Automated Conditional Screening of Multiple Escherichia coli Strains in Parallel Adaptive Fed-Batch Cultivations
Hans, Sebastian; Haby, Benjamin; Krausch, Niels et al. · 2020
Full title: Automated Conditional Screening of Multiple Escherichia coli Strains in Parallel Adaptive Fed-Batch Cultivations
Authors: Hans, Sebastian; Haby, Benjamin; Krausch, Niels; Barz, Tilman; Neubauer, Peter; Bournazou, Mariano Nicolás Cruz
Paper
Measurement of Oxygen Transfer Rate and Specific Oxygen Uptake Rate of h-iPSC Aggregates in Vertical Wheel Bioreactors to Predict Maximum Cell Density Before Oxygen Limitation
Kim, James; Agbojo, Omokhowa M.; Jung, Sunghoon et al. · 2025
Full title: Measurement of Oxygen Transfer Rate and Specific Oxygen Uptake Rate of h-iPSC Aggregates in Vertical Wheel Bioreactors to Predict Maximum Cell Density Before Oxygen Limitation
Authors: Kim, James; Agbojo, Omokhowa M.; Jung, Sunghoon; Croughan, Matthew S.
Paper
Hydrodynamics and Mass Transfer Analysis in BioFlow® Bioreactor Systems
Kordas, Marian; Konopacki, Maciej; Grygorcewicz, Bartłomiej et al. · 2020
Full title: Hydrodynamics and Mass Transfer Analysis in BioFlow® Bioreactor Systems
Authors: Kordas, Marian; Konopacki, Maciej; Grygorcewicz, Bartłomiej; Augustyniak, Adrian; Musik, Daniel; Wójcik, Krzysztof; Jędrzejczak-Silicka, Magdalena; Rakoczy, Rafał
Paper
Predicting By-Product Gradients of Baker’s Yeast Production at Industrial Scale: A Practical Simulation Approach
Hajian, Christopher Sarkizi Shams; Haringa, Cees; Noorman, Henk et al. · 2020
Full title: Predicting By-Product Gradients of Baker’s Yeast Production at Industrial Scale: A Practical Simulation Approach
Authors: Hajian, Christopher Sarkizi Shams; Haringa, Cees; Noorman, Henk; Takors, Ralf
Paper
Hybrid Approach for Mixing Time Characterization and Scale-Up in Geometrical Nonsimilar Stirred Vessels Equipped with Eccentric Multi-Impeller Systems—An Industrial Perspective
Michael C. Martinetz; F. Kaiser; M. Kellner et al. · 2021
Full title: Hybrid Approach for Mixing Time Characterization and Scale-Up in Geometrical Nonsimilar Stirred Vessels Equipped with Eccentric Multi-Impeller Systems—An Industrial Perspective
Authors: Michael C. Martinetz; F. Kaiser; M. Kellner; D. Schlosser; A. Lange; Michaela Brueckner-Pichler; C. Brocard; M. Šoóš
Paper
Monitoring Intracellular Metabolite Dynamics in Saccharomyces cerevisiae during Industrially Relevant Famine Stimuli
Minden, Steven; Aniolek, Maria; Hajian, Christopher Sarkizi Shams et al. · 2022
Full title: Monitoring Intracellular Metabolite Dynamics in Saccharomyces cerevisiae during Industrially Relevant Famine Stimuli
Authors: Minden, Steven; Aniolek, Maria; Hajian, Christopher Sarkizi Shams; Teleki, Attila; Zerrer, Tobias; Delvigne, Frank; Gulik, Walter van; Deshmukh, Amit T.; Noorman, Henk; Takors, Ralf
Paper
Glucose-Limited Fed-Batch Cultivation Strategy to Mimic Large-Scale Effects in Escherichia coli Linked to Accumulation of Non-Canonical Branched-Chain Amino Acids by Combination of Pyruvate Pulses and Dissolved Oxygen Limitation.
García, Ángel Córcoles; Hauptmann, Peter; Neubauer, Peter · 2021
Full title: Glucose-Limited Fed-Batch Cultivation Strategy to Mimic Large-Scale Effects in Escherichia coli Linked to Accumulation of Non-Canonical Branched-Chain Amino Acids by Combination of Pyruvate Pulses and Dissolved Oxygen Limitation.
Authors: García, Ángel Córcoles; Hauptmann, Peter; Neubauer, Peter
Paper
Optimization of YF17D-Vectored Zika Vaccine Production by Employing Small-Molecule Viral Sensitizers to Enhance Yields
Sven Göbel; Tilia Zinnecker; I. Jordan et al. · 2025
Full title: Optimization of YF17D-Vectored Zika Vaccine Production by Employing Small-Molecule Viral Sensitizers to Enhance Yields
Authors: Sven Göbel; Tilia Zinnecker; I. Jordan; V. Sandig; Andrea Vervoort; Jondavid de Jong; Jean-Simon Diallo; P. Satzer; Manfred Satzer; K. Dallmeier; Udo Reichl; Y. Genzel
Paper
Accumulation of amino acids deriving from pyruvate in &amp;lt;i&amp;gt;Escherichia coli&amp;lt;/i&amp;gt; W3110 during fed-batch cultivation in a two-compartment scale-down bioreactor
Soini, Jaakko; Ukkonen, Kaisa; Neubauer, Peter · 2011
Full title: Accumulation of amino acids deriving from pyruvate in &amp;lt;i&amp;gt;Escherichia coli&amp;lt;/i&amp;gt; W3110 during fed-batch cultivation in a two-compartment scale-down bioreactor
Authors: Soini, Jaakko; Ukkonen, Kaisa; Neubauer, Peter
Paper
Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
Kempf, Henning; Olmer, Ruth; Haase, Alexandra et al. · 2016
Full title: Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
Authors: Kempf, Henning; Olmer, Ruth; Haase, Alexandra; Franke, Annika; Bolesani, Emiliano; Schwanke, Kristin; Robles-Diaz, Diana; Coffee, Michelle; Göhring, Gudrun; Dräger, Gerald; Pötz, Oliver; Joos, Thomas; Martı́nez-Hackert, Erik; Haverich, Axel; Buettner, Falk F. R.; Martin, Ulrich; Zweigerdt, Robert
Paper
A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production.
Nicholas J. Mozdzierz; K. Love; K. Lee et al. · 2015
Full title: A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production.
Authors: Nicholas J. Mozdzierz; K. Love; K. Lee; Harry L. T. Lee; Kartik Shah; Rajeev J Ram; J. C. Love
Paper
Microbioreactor for lower cost and faster optimisation of protein production
Parekh, Mayur; ali, abdulaziz; Ali, Zulfiqur et al. · 2020
Full title: Microbioreactor for lower cost and faster optimisation of protein production
Authors: Parekh, Mayur; ali, abdulaziz; Ali, Zulfiqur; Bateson, Simon; Abugchem, Fathi; Pybus, Leon P.; Lennon, Christopher
Paper
Pseudo perfusion of Chinese Hamster Ovary (CHO) cells as a reliable platform for data generation to model and guide continuous perfusion biomanufacturing
Malinov, Nikola G.; Barodiya, Shivam; Ierapetritou, Marianthi et al. · 2025
Full title: Pseudo perfusion of Chinese Hamster Ovary (CHO) cells as a reliable platform for data generation to model and guide continuous perfusion biomanufacturing
Authors: Malinov, Nikola G.; Barodiya, Shivam; Ierapetritou, Marianthi; Papoutsakis, Eleftherios T.
Paper
Development and application of a cultivation platform for mammalian suspension cell lines with single-cell resolution (MaSC)
Schmitz, Julian; Täuber, Sarah; Westerwalbesloh, Christoph et al. · 2020
Full title: Development and application of a cultivation platform for mammalian suspension cell lines with single-cell resolution (MaSC)
Authors: Schmitz, Julian; Täuber, Sarah; Westerwalbesloh, Christoph; Lieres, Eric von; Noll, Thomas; Grünberger, Alexander
Paper
Microfluidic single-cell scale-down bioreactors: A proof-of-concept for the growth of <i>Corynebacterium glutamicum</i> at oscillating pH values
Täuber, Sarah; Blöbaum, Luisa; Steier, Valentin et al. · 2022
Full title: Microfluidic single-cell scale-down bioreactors: A proof-of-concept for the growth of <i>Corynebacterium glutamicum</i> at oscillating pH values
Authors: Täuber, Sarah; Blöbaum, Luisa; Steier, Valentin; Oldiges, Marco; Grünberger, Alexander
Paper
Optimal operation of parallel mini-bioreactors in bioprocess development using multi-stage MPC
Krausch, Niels; Kim, Jong Woo; Lucia, Sergio et al. · 2021
Full title: Optimal operation of parallel mini-bioreactors in bioprocess development using multi-stage MPC
Authors: Krausch, Niels; Kim, Jong Woo; Lucia, Sergio; Groß, Sebastian; Barz, Tilman; Neubauer, Peter; Bournazou, Mariano Nicolás Cruz
Paper
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Full title: An automated workflow for enhancing microbial bioprocess optimization on a novel microbioreactor platform
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Miniature bioreactors: current practices and future opportunities.
Betts, Jonathan Ian; Baganz, Frank · 2006
Full title: Miniature bioreactors: current practices and future opportunities.
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Bioreactor mixing efficiency modulates the activity of a prpoS::GFP reporter gene in E. coli
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High cell density media for Escherichia coli are generally designed for aerobic cultivations - consequences for large-scale bioprocesses and shake flask cultures.
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Full title: High cell density media for Escherichia coli are generally designed for aerobic cultivations - consequences for large-scale bioprocesses and shake flask cultures.
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Exometabolome analysis reveals hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process
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Developing a scalable model of recombinant protein yield from Pichia pastoris: the influence of culture conditions, biomass and induction regime
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Full title: Developing a scalable model of recombinant protein yield from Pichia pastoris: the influence of culture conditions, biomass and induction regime
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Comparisons of optically monitored small-scale stirred tank vessels to optically controlled disposable bag bioreactors.
Hanson, Michael A; Brorson, Kurt A; Moreira, Antonio R et al. · 2009
Full title: Comparisons of optically monitored small-scale stirred tank vessels to optically controlled disposable bag bioreactors.
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Antibody disulfide bond reduction during process development: Insights using a scale-down model process
Julie Ruaudel; M. Bertschinger; Sonia Letestu et al. · 2015
Full title: Antibody disulfide bond reduction during process development: Insights using a scale-down model process
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Bioprocess Control in Microscale: Scalable Fermentations in Disposable and User-Friendly Microfluidic Systems
Funke, Matthias; Buchenauer, Andreas; Mokwa, W. et al. · 2010
Full title: Bioprocess Control in Microscale: Scalable Fermentations in Disposable and User-Friendly Microfluidic Systems
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Validation of a high-throughput fermentation system based on online monitoring of biomass and fluorescence in continuously shaken microtiter plates
Kensy, Frank; Zang, Emerson; Faulhammer, Christian et al. · 2009
Full title: Validation of a high-throughput fermentation system based on online monitoring of biomass and fluorescence in continuously shaken microtiter plates
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Development and fine-tuning of a scale down model for process characterization studies of a monoclonal antibody upstream production process.
Harmsen, Mareike; Stofferis, Jimmy; Malphettes, Laetitia · 2011
Full title: Development and fine-tuning of a scale down model for process characterization studies of a monoclonal antibody upstream production process.
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Escherichia coli metabolism under short-term repetitive substrate dynamics: adaptation and trade-offs
Vasilakou, Eleni; Loosdrecht, Mark C.M. van; Wahl, A. · 2020
Full title: Escherichia coli metabolism under short-term repetitive substrate dynamics: adaptation and trade-offs
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Scale-up from microtiter plate to laboratory fermenter: evaluation by online monitoring techniques of growth and protein expression in Escherichia coli and Hansenula polymorpha fermentations
Kensy, Frank; Engelbrecht, Christoph; Büchs, Jochen · 2009
Full title: Scale-up from microtiter plate to laboratory fermenter: evaluation by online monitoring techniques of growth and protein expression in Escherichia coli and Hansenula polymorpha fermentations
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How to assess chemically defined media and feeds from 9 suppliers on CHO cells producing mAb
Aurore Polès-Lahille; Margaux Paillet; Aurélie Da Silva et al. · 2013
Full title: How to assess chemically defined media and feeds from 9 suppliers on CHO cells producing mAb
Authors: Aurore Polès-Lahille; Margaux Paillet; Aurélie Da Silva; Nora Kadi; E. Basque; Flavien Thuet; D. Balbuena; S. Ribault
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Technology transfer and scale down model development strategy for biotherapeutics produced in mammalian cells
N. Kochanowski; Laetitia Malphettes · 2013
Full title: Technology transfer and scale down model development strategy for biotherapeutics produced in mammalian cells
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Automation assisted anaerobic phenotyping for metabolic engineering.
Raj, Kaushik; Venayak, Naveen; Diep, Patrick et al. · 2021
Full title: Automation assisted anaerobic phenotyping for metabolic engineering.
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The way to a design space for an animal cell culture process according to Quality by Design (QbD)
R. Puskeiler; Jan Kreuzmann; Caroline Schuster et al. · 2011
Full title: The way to a design space for an animal cell culture process according to Quality by Design (QbD)
Authors: R. Puskeiler; Jan Kreuzmann; Caroline Schuster; K. Didzus; Nicole Bartsch; Christian Hakemeyer; H. Schmidt; Melanie Jacobs; Stefan Wolf
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Parallel use of shake flask and microtiter plate online measuring devices (RAMOS and BioLector) reduces the number of experiments in laboratory-scale stirred tank bioreactors
Wewetzer, Sandra; Kunze, Martin; Ladner, Tobias et al. · 2015
Full title: Parallel use of shake flask and microtiter plate online measuring devices (RAMOS and BioLector) reduces the number of experiments in laboratory-scale stirred tank bioreactors
Authors: Wewetzer, Sandra; Kunze, Martin; Ladner, Tobias; Luchterhand, Bettina; Roth, Simon; Rahmen, Natalie; Kloß, Ramona; Silva, A. Costa e; Regestein, Lars; Büchs, Jochen
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Microfabricated Modular Scale-Down Device for Regenerative Medicine Process Development
Reichen, Marcel; Macown, Rhys J.; Jaccard, Nicolas et al. · 2012
Full title: Microfabricated Modular Scale-Down Device for Regenerative Medicine Process Development
Authors: Reichen, Marcel; Macown, Rhys J.; Jaccard, Nicolas; Super, Alexandre; Ruban, Ludmila; Griffin, Lewis D.; Veraitch, Farlan; Szita, Nicolas
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Novel low shear 3D bioreactor for high purity mesenchymal stem cell production
Burns, Andrew; Doris, Corinna; Vehar, Kevin et al. · 2021
Full title: Novel low shear 3D bioreactor for high purity mesenchymal stem cell production
Authors: Burns, Andrew; Doris, Corinna; Vehar, Kevin; Saxena, Vinit; Bardliving, Cameron; Shamlou, P. Ayazi; Phillips, M. Ian
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Flow Characterization of a Spinner Flask for Induced Pluripotent Stem Cell Culture Application
Ismadi, Mohd‐Zulhilmi; Gupta, Priyanka; Fouras, Andreas et al. · 2014
Full title: Flow Characterization of a Spinner Flask for Induced Pluripotent Stem Cell Culture Application
Authors: Ismadi, Mohd‐Zulhilmi; Gupta, Priyanka; Fouras, Andreas; Verma, Paul J.; Jadhav, Sameer; Bellare, Jayesh; Hourigan, Kerry
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Scale-down bioreactors-comparative analysis of configurations.
Arulrajah, Prasika; Lievonen, Anni Elina; Subaşı, Dilara et al. · 2025
Full title: Scale-down bioreactors-comparative analysis of configurations.
Authors: Arulrajah, Prasika; Lievonen, Anni Elina; Subaşı, Dilara; Pagal, Subhashree; Weuster-Botz, Dirk; Heins, Anna-Lena
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Bovine myoblast cell production in a microcarriers-based system
Verbruggen, Sanne; Luining, Daan; Essen, Anon van et al. · 2017
Full title: Bovine myoblast cell production in a microcarriers-based system
Authors: Verbruggen, Sanne; Luining, Daan; Essen, Anon van; Post, Mark J.
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Morphology-driven downscaling of Streptomyces lividans to micro-cultivation
Dissel, Dino van; Wezel, Gilles P. van · 2017
Full title: Morphology-driven downscaling of Streptomyces lividans to micro-cultivation
Authors: Dissel, Dino van; Wezel, Gilles P. van
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Does the BioBLU 0.3f single-use scale to the BioFlo® 320 reuseable bioreactor on a matched volumetric oxygen mass transfer coefficient?
Olughu, Williams; Galbraith, Duncan M.; Paget, Cillian et al. · 2021
Full title: Does the BioBLU 0.3f single-use scale to the BioFlo® 320 reuseable bioreactor on a matched volumetric oxygen mass transfer coefficient?
Authors: Olughu, Williams; Galbraith, Duncan M.; Paget, Cillian; Ruscoe, Steve; Smith, Josh; Mason, Alison
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Indicators for optical oxygen sensors
Quaranta, Michela; Borisov, Sergey M.; Klimant, Ingo · 2012
Full title: Indicators for optical oxygen sensors
Authors: Quaranta, Michela; Borisov, Sergey M.; Klimant, Ingo
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Process Validation in Manufacturing of Biopharmaceuticals
A. Rathore; G. Sofer · 2012
Full title: Process Validation in Manufacturing of Biopharmaceuticals
Authors: A. Rathore; G. Sofer
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Engineering of Scale-Down Bioreactor Setup: Deciphering Metabolic Phenotype of Corynebacterium glutamicum under Simulated Bioreactor Inhomogeneity
M. Limberg; W. Wiechert; M. Oldiges et al. · 2017
Full title: Engineering of Scale-Down Bioreactor Setup: Deciphering Metabolic Phenotype of Corynebacterium glutamicum under Simulated Bioreactor Inhomogeneity
Authors: M. Limberg; W. Wiechert; M. Oldiges; L. Blank
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Influence of Microenvironment on Mesenchymal Stem Cell Therapeutic Potency: From Planar Culture to Microcarriers
Tsai, Ang‐Chen; Jeske, Richard; Chen, Xingchi et al. · 2020
Full title: Influence of Microenvironment on Mesenchymal Stem Cell Therapeutic Potency: From Planar Culture to Microcarriers
Authors: Tsai, Ang‐Chen; Jeske, Richard; Chen, Xingchi; Yuan, Xuegang; Li, Yan
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Modern Sensor Tools and Techniques for Monitoring, Controlling, and Improving Cell Culture Processes
Reyes, Sebastian Juan; Durocher, Yves; Pham, Phuong Lan et al. · 2022
Full title: Modern Sensor Tools and Techniques for Monitoring, Controlling, and Improving Cell Culture Processes
Authors: Reyes, Sebastian Juan; Durocher, Yves; Pham, Phuong Lan; Henry, Olivier
Paper
Lentiviral Vector Bioprocessing
Perry, Christopher; Rayat, Andrea · 2021
Full title: Lentiviral Vector Bioprocessing
Authors: Perry, Christopher; Rayat, Andrea
Paper
The effect of potential large-scale bioreactor environmental heterogeneities during fed-batch culture on the performance of an industrially-relevant GS-CHO cell culture, producing an IgG antibody
Scott, William H. · 2011
Full title: The effect of potential large-scale bioreactor environmental heterogeneities during fed-batch culture on the performance of an industrially-relevant GS-CHO cell culture, producing an IgG antibody
Authors: Scott, William H.
Paper
Two-compartment bioreactor as a scale-down model to study the effect of glucose overflow and anaerobiosis on large-scale recombinant protein production processes
Soini, Jaakko; Pajulampi, Ulla; Sandqvist, Janne et al. · 2006
Full title: Two-compartment bioreactor as a scale-down model to study the effect of glucose overflow and anaerobiosis on large-scale recombinant protein production processes
Authors: Soini, Jaakko; Pajulampi, Ulla; Sandqvist, Janne; Matzen, Arne; Neubauer, Peter
Paper
Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments
Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald et al. · 2021
Full title: Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments
Authors: Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald; Sissolak, Bernhard
Paper
Novel oscillatory flow reactors for biotechnological applications
Reis, Nuno M. · 2006
Full title: Novel oscillatory flow reactors for biotechnological applications
Authors: Reis, Nuno M.
Thesis
Influence of shear stress by gas aspersion in Baculovirus production by SF9 cells in bioreactor
Tonso, Aldo · 2018
Full title: Influence of shear stress by gas aspersion in Baculovirus production by SF9 cells in bioreactor
Authors: Tonso, Aldo
Thesis
Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
Monsalve-Bravo, Gloria M; Garelli, Fabricio; Mozumder, Salatul Islam et al. · 2015
Full title: Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
Authors: Monsalve-Bravo, Gloria M; Garelli, Fabricio; Mozumder, Salatul Islam; Alvarez, Hernan; De Battista, Hernán
Thesis
Enhancing the Functionality of a Microscale Bioreactor System as an Industrial Process Development Tool for Mammalian Perfusion Culture
Sewell, David J; Turner, Richard; Field, Ray et al. · 2019
Full title: Enhancing the Functionality of a Microscale Bioreactor System as an Industrial Process Development Tool for Mammalian Perfusion Culture
Authors: Sewell, David J; Turner, Richard; Field, Ray; Holmes, William; Pradhan, Rahul; Spencer, Christopher; Oliver, Stephen; Slater, Nigel; Dikicioglu, Duygu
Thesis
Computational Fluid Dynamics Simulations of Single-Use Bioreactors for the Scale-Up of Cell Culture Processes
Kreitmayer, Diana · 2022
Full title: Computational Fluid Dynamics Simulations of Single-Use Bioreactors for the Scale-Up of Cell Culture Processes
Authors: Kreitmayer, Diana
Thesis
Tools for the development of intensified perfusion processes for mammalian cell culture
Schwarz, Hubert · 2022
Full title: Tools for the development of intensified perfusion processes for mammalian cell culture
Authors: Schwarz, Hubert
Thesis
A computational framework for predicting CHO cell culture performance in bioreactors
Cárcamo Behrens, Martín. · 2019
Full title: A computational framework for predicting CHO cell culture performance in bioreactors
Authors: Cárcamo Behrens, Martín.
Thesis
Model-based Design and Control of Biopharmaceutical Manufacturing Processes
Hong, Moo Sun · 2022
Full title: Model-based Design and Control of Biopharmaceutical Manufacturing Processes
Authors: Hong, Moo Sun
Thesis
Improving predictability of cell culture processes during biologics manufacturing scale-up through hybrid modeling
Wolszon, Zoë. · 2020
Full title: Improving predictability of cell culture processes during biologics manufacturing scale-up through hybrid modeling
Authors: Wolszon, Zoë.
Thesis
Oxygen transport in animal cell biogreactors with vibrating-plate aerators
Nayar, Gautam · 2007
Full title: Oxygen transport in animal cell biogreactors with vibrating-plate aerators
Authors: Nayar, Gautam
Thesis
Micro-bioreactor design for Chinese hamster ovary cells
Goh, Shireen · 2013
Full title: Micro-bioreactor design for Chinese hamster ovary cells
Authors: Goh, Shireen
Thesis
High-Throughput Platform Development for Chinese Hamster Ovary (CHO) Cell Culture Performance Enhancement Using Small Molecules.
Kalsi, Devika · 2018
Full title: High-Throughput Platform Development for Chinese Hamster Ovary (CHO) Cell Culture Performance Enhancement Using Small Molecules.
Authors: Kalsi, Devika
Thesis
Integration of CFD Bioreactor Models with Cell Growth Models for the Scale-Up of Cultivated Meat
Kiviat, Kira Leigh · 2024
Full title: Integration of CFD Bioreactor Models with Cell Growth Models for the Scale-Up of Cultivated Meat
Authors: Kiviat, Kira Leigh
Thesis
Modeling sparging related death in animal cell bioreactors
Meier, Steven J. (Steven John), 1969- · 2009
Full title: Modeling sparging related death in animal cell bioreactors
Authors: Meier, Steven J. (Steven John), 1969-
Thesis
Studies on the characterization of the hydrodynamic environment in sparged animal cell cultures /
Garcia-Briones, Miguel Angel · 1994
Full title: Studies on the characterization of the hydrodynamic environment in sparged animal cell cultures /
Authors: Garcia-Briones, Miguel Angel
Thesis
Study of Hydrodynamics Due to Turbulent Mixing in Animal Cell Microcarrier Bioreactors /
Venkat, Raghavan V. · 1995
Full title: Study of Hydrodynamics Due to Turbulent Mixing in Animal Cell Microcarrier Bioreactors /
Authors: Venkat, Raghavan V.
Thesis
Bioreactor processes based on disposable materials for the production of recombinant proteins from mammalian cells
Stettler, Matthieu · 2007
Full title: Bioreactor processes based on disposable materials for the production of recombinant proteins from mammalian cells
Authors: Stettler, Matthieu
Thesis
OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up
Tissot, Stéphanie · 2011
Full title: OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up
Authors: Tissot, Stéphanie
Thesis
Predictive models for upstream mammalian cell culture development: a review
Yatipanthalawa, BS; Gras, SL · 2023
Full title: Predictive models for upstream mammalian cell culture development: a review
Authors: Yatipanthalawa, BS; Gras, SL
Thesis
Kontinuierliche Bioprozessführung in miniaturisierten Rührkesselreaktoren
Schmideder, Andreas · 2016
Full title: Kontinuierliche Bioprozessführung in miniaturisierten Rührkesselreaktoren
Authors: Schmideder, Andreas
Thesis
Strömungssimulation als Werkzeug zur Bioreaktorcharakterisierung
Brüning, Stefanie · 2015
Full title: Strömungssimulation als Werkzeug zur Bioreaktorcharakterisierung
Authors: Brüning, Stefanie
Thesis
Scale-down and parallel operation of a riboflavin production process with Bacillus subtilis
Knorr, Bettina · 2007
Full title: Scale-down and parallel operation of a riboflavin production process with Bacillus subtilis
Authors: Knorr, Bettina
Thesis
Reaktionstechnische Optimierung von Parallelreaktoren für kontrollierte Bioprozesse
Kusterer, Andreas · 2008
Full title: Reaktionstechnische Optimierung von Parallelreaktoren für kontrollierte Bioprozesse
Authors: Kusterer, Andreas
Thesis
Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand
Chua, Gek Kee · 2011
Full title: Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand
Authors: Chua, Gek Kee
Thesis
Miniaturisierte Parallelreaktoren zur Hochdurchsatz-Bioprozessentwicklung
Puskeiler, Robert · 2007
Full title: Miniaturisierte Parallelreaktoren zur Hochdurchsatz-Bioprozessentwicklung
Authors: Puskeiler, Robert
Thesis
Development of a novel bioreactor and systems for suspension cell culture in biopharmaceutical production
Sharma, Rajesh · 2022
Full title: Development of a novel bioreactor and systems for suspension cell culture in biopharmaceutical production
Authors: Sharma, Rajesh
Thesis
Effects of imperfect mixing in suspended plant and animal cell cultures
Cheung, Caleb Kin Lok · 2006
Full title: Effects of imperfect mixing in suspended plant and animal cell cultures
Authors: Cheung, Caleb Kin Lok
Thesis
Microbubble fermentation of recombinant Pichia pastoris for human serum albumin production
Zhang, Wei · 2014
Full title: Microbubble fermentation of recombinant Pichia pastoris for human serum albumin production
Authors: Zhang, Wei
Thesis
The Biological Impact of High Throughput Continuous Bioprocessing
Sewell, David John · 2020
Full title: The Biological Impact of High Throughput Continuous Bioprocessing
Authors: Sewell, David John
Thesis
Disseny i desenvolupament de minibioreactors amb instrumentació per a l’optimització de cultius cel· lulars
Soley Astals, Albert · 2011
Full title: Disseny i desenvolupament de minibioreactors amb instrumentació per a l’optimització de cultius cel· lulars
Authors: Soley Astals, Albert
Thesis
A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production
Lee, Kevin S.; Lee, Harry L. T.; Mozdzierz, Nicholas Joseph et al. · 2017
Full title: A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production
Authors: Lee, Kevin S.; Lee, Harry L. T.; Mozdzierz, Nicholas Joseph; Love, Kerry R.; Shah, Kartik A; Ram, Rajeev J; Love, John C
Thesis
Preemptive variation reduction in biologic drug substance manufacturing
Güereca Valdivia, Ismael · 2024
Full title: Preemptive variation reduction in biologic drug substance manufacturing
Authors: Güereca Valdivia, Ismael
Thesis
Fed-batch microbioreactor platform for scale down and analysis of a plasmid DNA production process
Bower, Diana Morgan; Lee, Kevin Shao-Kwan; Ram, Rajeev J et al. · 2019
Full title: Fed-batch microbioreactor platform for scale down and analysis of a plasmid DNA production process
Authors: Bower, Diana Morgan; Lee, Kevin Shao-Kwan; Ram, Rajeev J; Prather, Kristala L
Thesis
Effect of Gas Sparging in Mammalian Cell Bioreactors
Wang, Daniel I.C.; Orton, Dawn · 2005
Full title: Effect of Gas Sparging in Mammalian Cell Bioreactors
Authors: Wang, Daniel I.C.; Orton, Dawn
Thesis
Detection of Circulating Tumor Cells in Peripheral Blood and Mixing Time Quantification in Millipore Disposable Bioreactors
Sadeli, Adeline R. · 2011
Full title: Detection of Circulating Tumor Cells in Peripheral Blood and Mixing Time Quantification in Millipore Disposable Bioreactors
Authors: Sadeli, Adeline R.
Thesis
Helical-Track Bioreactors for Bacterial, Mammalian and Insect Cell Cultures
Tissot, Stéphanie; Michel, Patrik; Douet, Clara et al. · 2013
Full title: Helical-Track Bioreactors for Bacterial, Mammalian and Insect Cell Cultures
Authors: Tissot, Stéphanie; Michel, Patrik; Douet, Clara; Grezet, Sarah; Baldi, Lucia; Hacker, David; Wurm, Florian
Thesis
Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells
Meuwly, F.; von Stockar, U.; Kadouri, A. · 2006
Full title: Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells
Authors: Meuwly, F.; von Stockar, U.; Kadouri, A.
Thesis
Bioreactor Controls for High Oxygen Uptake Rate (OUR) Demand Processes
Cho, Hyun Woo · 2019
Full title: Bioreactor Controls for High Oxygen Uptake Rate (OUR) Demand Processes
Authors: Cho, Hyun Woo
Thesis
Screening for Antibody Reduction at the Clone Selection Stage to Prevent Reduction During Manufacturing
Lakhani, Aliya Abdulaziz · 2019
Full title: Screening for Antibody Reduction at the Clone Selection Stage to Prevent Reduction During Manufacturing
Authors: Lakhani, Aliya Abdulaziz
Thesis
Developing a CFD-based axial compartment model for a lab scale bioreactor
Karawan, Blake A. · 2022
Full title: Developing a CFD-based axial compartment model for a lab scale bioreactor
Authors: Karawan, Blake A.
Thesis
Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture
Shariatzadeh, M; Lopes, AG; Glen, KE et al. · 2021
Full title: Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture
Authors: Shariatzadeh, M; Lopes, AG; Glen, KE; Sinclair, A; Thomas, RJ
Thesis
A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments
Karimi Alavijeh, M; Lee, YY; Gras, SL · 2024
Full title: A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments
Authors: Karimi Alavijeh, M; Lee, YY; Gras, SL
Thesis
Hydrodynamics considerations in cells systems from ocean flow to perfusion cultivation process
Zhan, Caijuan · 2019
Full title: Hydrodynamics considerations in cells systems from ocean flow to perfusion cultivation process
Authors: Zhan, Caijuan
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· 2021
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· 2022
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· 2022
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· 2024
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· 2024
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· 2024
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· 2024
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us-2024101950-a1
· 2024
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· 2025
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· 2025
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Full title: us-2025171742-a1
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us-2025154445-a1
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us-4643972-a
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us-2025327014-a1
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Full title: us-2025327014-a1
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us-5102790-a
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Full title: us-5102790-a
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us-5187095-a
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us-7442538-b2
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Full title: us-7442538-b2
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us-7099721-b2
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Full title: us-8241904-b2
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us-8822198-b2
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Full title: us-8822198-b2
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Full title: us-9550972-b2
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us-10131868-b2
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Full title: us-10870822-b2
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Full title: us-12221602-b2
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us-12227732-b2
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us-2004030516-a1
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Full title: us-2004030516-a1
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us-2006199260-a1
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us-2007269888-a1
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Full title: us-9969965-b2

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