Pat Tools For Real Time Monitoring Of Critical Qua

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445 papers 407 patents 348 theses

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Paper Probeless non-invasive near-infrared spectroscopic bioprocess monitoring using microspectrometer technology

Zimmerleiter, Robert; Kager, Julian; Nikzad‐Langerodi, Ramin et al. · 2019 · Analytical and Bioanalytical Chemistry · DOI

Full title: Probeless non-invasive near-infrared spectroscopic bioprocess monitoring using microspectrometer technology

Authors: Zimmerleiter, Robert; Kager, Julian; Nikzad‐Langerodi, Ramin; Berezhinskiy, Vladimir; Westad, Frank; Herwig, Christoph; Brandstetter, Markus

Year: 2019

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-019-02227-w

Paper A novel toolbox for E. coli lysis monitoring

Rajamanickam, Vignesh; Wurm, David Johannes; Slouka, Christoph et al. · 2016 · Analytical and Bioanalytical Chemistry · DOI

Full title: A novel toolbox for E. coli lysis monitoring

Authors: Rajamanickam, Vignesh; Wurm, David Johannes; Slouka, Christoph; Herwig, Christoph; Spadiut, Oliver

Year: 2016

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-016-9907-z

Paper The role of Raman spectroscopy in biopharmaceuticals from development to manufacturing.

Esmonde-White, Karen A; Cuellar, Maryann; Lewis, Ian R · 2022 · Analytical and bioanalytical chemistry · DOI

Full title: The role of Raman spectroscopy in biopharmaceuticals from development to manufacturing.

Authors: Esmonde-White, Karen A; Cuellar, Maryann; Lewis, Ian R

Year: 2022

Venue: Analytical and bioanalytical chemistry

DOI: https://doi.org/10.1007/s00216-021-03727-4

Paper Biopharmaceutical analysis — current analytical challenges, limitations, and perspectives

Cunha, Diana R; Garcia, M. Beatriz Q.; Segundo, Marcela A. · 2025 · Analytical and Bioanalytical Chemistry · DOI

Full title: Biopharmaceutical analysis — current analytical challenges, limitations, and perspectives

Authors: Cunha, Diana R; Garcia, M. Beatriz Q.; Segundo, Marcela A.

Year: 2025

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-025-06036-2

Paper Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra

Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn et al. · 2021 · Analytical and Bioanalytical Chemistry · DOI

Full title: Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra

Authors: Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn; Mastrobattista, Enrico; Yamabhai, Montarop

Year: 2021

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-021-03549-4

Paper Bioanalytical Reviews

Quaranta, Michela; Borisov, Sergey M.; Klimant, Ingo et al. · 2016 · Bioanalytical reviews · DOI

Full title: Bioanalytical Reviews

Authors: Quaranta, Michela; Borisov, Sergey M.; Klimant, Ingo; Alava-Moreno, F; Valencia-Gonzalez, M; Sanz-Medel, A; Diaz-Garcia, M; Alford, P; Cook, M; Lewis, Apmgsg; Skarda, V; Thomson, A; Glasper, J; Robbins, D; Amao, Y; Amao, Y; Asai, K; Okura, I; Amao, Y; Asai, K; Okura, I; Amao, Y; Asai, Koi; Shinohara, H; Nishide, H; Amao, Y; Ishikawa, Y; Okura, I; Amao, Y; Ishikawa, Y; Okura, I; Miyashita, T; Amao, Y; Miyashita, T; Okura, I; Amao, Y; Okura, I; Amao, Y; Okura, I; Amao, Y; Okura, I; Miyashita, T; Amao, Y; Okura, I; Miyashita, T; Amao, Y; Tabuchi, Y; Yamashita, Y; Kimura, K; Anni, M; Rella, R; Arain, S; Gernot, J; Krause, C; Gerlach, J; Wolfbeis, O; Klimant, I; Babilas, P; Lamby, P; Prantl, L; Schreml, S; Jung, E; Liebsch, G; Wolfbeis, O; Landthaler, M; Szeimies, R-M; Abels, C; Badocco, D; Mondin, A; Pastore, P; Voltolina, S; Gross, S; Baldini, F; Bacci, M; Cosi, F; Bianco, Adb; Basu, B; Anandan, C; Rajam, K; Basu, B; Thirumurugan, A; Dinesh, A; Anandan, C; Rajam, K; Bergman, I; Bizzarri, A; Koehler, H; Cajlakovic, M; Pasic, A; Schaupp, L; Klimant, I; Ribitsch, V; Borisov, S; Klimant, I; Borisov, Smlp; Klimant, I; Borisov, S; Klimant, I; Borisov, S; Nuss, G

Year: 2016

Venue: Bioanalytical reviews

DOI: https://doi.org/10.1007/12566.1867-2094

Paper A process analyzer assembly for real-time automated near-infrared, Raman, and proton nuclear magnetic resonance spectroscopic monitoring enhanced by heterocovariance spectroscopy and chemometry applied to a Schiff base formation

Wilbert, Dominik; Voigt, Melanie; Jaeger, Martin · 2025 · Analytical and Bioanalytical Chemistry · DOI

Full title: A process analyzer assembly for real-time automated near-infrared, Raman, and proton nuclear magnetic resonance spectroscopic monitoring enhanced by heterocovariance spectroscopy and chemometry applied to a Schiff base formation

Authors: Wilbert, Dominik; Voigt, Melanie; Jaeger, Martin

Year: 2025

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-025-05945-6

Paper Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing.

Esmonde-White, Karen A; Cuellar, Maryann; Uerpmann, Carsten et al. · 2017 · Analytical and bioanalytical chemistry · DOI

Full title: Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing.

Authors: Esmonde-White, Karen A; Cuellar, Maryann; Uerpmann, Carsten; Lenain, Bruno; Lewis, Ian R

Year: 2017

Venue: Analytical and bioanalytical chemistry

DOI: https://doi.org/10.1007/s00216-016-9824-1

Paper A robust flow cytometry-based biomass monitoring tool enables rapid at-line characterization of S. cerevisiae physiology during continuous bioprocessing of spent sulfite liquor

Vees, Charlotte Anne; Veiter, Lukas; Sax, Fritz et al. · 2020 · Analytical and Bioanalytical Chemistry · DOI

Full title: A robust flow cytometry-based biomass monitoring tool enables rapid at-line characterization of S. cerevisiae physiology during continuous bioprocessing of spent sulfite liquor

Authors: Vees, Charlotte Anne; Veiter, Lukas; Sax, Fritz; Herwig, Christoph; Pflügl, Stefan

Year: 2020

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-020-02423-z

Paper Becoming fully circular facilitated by PAT

Eifert, Tobias; Gerlach, Martin; Dahlmann, Katharina et al. · 2025 · Analytical and Bioanalytical Chemistry · DOI

Full title: Becoming fully circular facilitated by PAT

Authors: Eifert, Tobias; Gerlach, Martin; Dahlmann, Katharina; Lendl, Bernhard; Rädle, Matthias; Jaeger, Martin

Year: 2025

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-025-05977-y

Paper Monitoring of ultra- and diafiltration processes by Kalman-filtered Raman measurements

Rolinger, Laura; Hubbuch, Jürgen; Rüdt, Matthias · 2023 · Analytical and Bioanalytical Chemistry · DOI

Full title: Monitoring of ultra- and diafiltration processes by Kalman-filtered Raman measurements

Authors: Rolinger, Laura; Hubbuch, Jürgen; Rüdt, Matthias

Year: 2023

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-022-04477-7

Paper Metrological traceability in process analytical technologies and point-of-need technologies for food safety and quality control: not a straightforward issue

Mattarozzi, Monica; Laski, Eleni; Bertucci, Alessandro et al. · 2022 · Analytical and Bioanalytical Chemistry · DOI

Full title: Metrological traceability in process analytical technologies and point-of-need technologies for food safety and quality control: not a straightforward issue

Authors: Mattarozzi, Monica; Laski, Eleni; Bertucci, Alessandro; Giannetto, Marco; Bianchi, Federica; Zoani, Claudia; Careri, Maria

Year: 2022

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-022-04398-5

Paper Micro simulated moving bed chromatography-mass spectrometry as a continuous on-line process analytical tool

Diehm, Juliane; Witting, Lennart; Kirschhöfer, Frank et al. · 2023 · Analytical and Bioanalytical Chemistry · DOI

Full title: Micro simulated moving bed chromatography-mass spectrometry as a continuous on-line process analytical tool

Authors: Diehm, Juliane; Witting, Lennart; Kirschhöfer, Frank; Brenner‐Weiß, Gerald; Franzreb, Matthias

Year: 2023

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-023-05023-9

Paper Synthetic spectral libraries for Raman model calibration

Hellequin, Louis; Borràs, Vicent J.; Romann, Patrick et al. · 2025 · Analytical and Bioanalytical Chemistry · DOI

Full title: Synthetic spectral libraries for Raman model calibration

Authors: Hellequin, Louis; Borràs, Vicent J.; Romann, Patrick; Vishwanathan, Nandita; Souquet, Jonathan; Villiger, Thomas K.

Year: 2025

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-025-05985-y

Paper The Good pH probe: non-invasive pH in-line monitoring using Good buffers and Raman spectroscopy

Müller, David Heinrich; Börger, Marieke; Thien, Julia et al. · 2023 · Analytical and Bioanalytical Chemistry · DOI

Full title: The Good pH probe: non-invasive pH in-line monitoring using Good buffers and Raman spectroscopy

Authors: Müller, David Heinrich; Börger, Marieke; Thien, Julia; Koß, Hans‐Jürgen

Year: 2023

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-023-04993-0

Paper Single compound data supplementation to enhance transferability of fermentation specific Raman spectroscopy models

Klaverdijk, Maarten; Ottens, Marcel; Klijn, Marieke E. · 2025 · Analytical and Bioanalytical Chemistry · DOI

Full title: Single compound data supplementation to enhance transferability of fermentation specific Raman spectroscopy models

Authors: Klaverdijk, Maarten; Ottens, Marcel; Klijn, Marieke E.

Year: 2025

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-025-05768-5

Paper On-line glucose monitoring by near infrared spectroscopy during the scale up steps of mammalian cell cultivation process development

Kozma, Bence; Salgó, András; Gergely, Szilveszter · 2019 · Bioprocess and Biosystems Engineering · DOI

Full title: On-line glucose monitoring by near infrared spectroscopy during the scale up steps of mammalian cell cultivation process development

Authors: Kozma, Bence; Salgó, András; Gergely, Szilveszter

Year: 2019

Venue: Bioprocess and Biosystems Engineering

DOI: https://doi.org/10.1007/s00449-019-02091-z

Paper Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors

Metze, Sabrina; Ruhl, S. F.; Greller, Gerhard et al. · 2019 · Bioprocess and Biosystems Engineering · DOI

Full title: Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors

Authors: Metze, Sabrina; Ruhl, S. F.; Greller, Gerhard; Grimm, C.; Scholz, Judith

Year: 2019

Venue: Bioprocess and Biosystems Engineering

DOI: https://doi.org/10.1007/s00449-019-02216-4

Paper Hyperspectral image and chemometrics. A step beyond classical spectroscopic PAT tools.

de Juan, Anna; de Oliveira, Rodrigo Rocha · 2026 · Analytical and bioanalytical chemistry · DOI

Full title: Hyperspectral image and chemometrics. A step beyond classical spectroscopic PAT tools.

Authors: de Juan, Anna; de Oliveira, Rodrigo Rocha

Year: 2026

Venue: Analytical and bioanalytical chemistry

DOI: https://doi.org/10.1007/s00216-025-06154-x

Paper Advances in monitoring and control of refolding kinetics combining PAT and modeling

Pauk, Jan Niklas; Palanisamy, Janani Raju; Kager, Julian et al. · 2021 · Applied Microbiology and Biotechnology · DOI

Full title: Advances in monitoring and control of refolding kinetics combining PAT and modeling

Authors: Pauk, Jan Niklas; Palanisamy, Janani Raju; Kager, Julian; Koczka, Krisztina; Berghammer, Gerald; Herwig, Christoph; Veiter, Lukas

Year: 2021

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-021-11151-y

Paper A New Index to Detect Process Deviations Using IR Spectroscopy and Chemometrics Process Tools

Schorn‐García, Daniel; Ezenarro, Jokin; Busto, Olga et al. · 2023 · Food and Bioprocess Technology · DOI

Full title: A New Index to Detect Process Deviations Using IR Spectroscopy and Chemometrics Process Tools

Authors: Schorn‐García, Daniel; Ezenarro, Jokin; Busto, Olga; Aceña, Laura; Boqué, Ricard; Mestres, Montserrat; Giussani, Barbara

Year: 2023

Venue: Food and Bioprocess Technology

DOI: https://doi.org/10.1007/s11947-023-03266-z

Paper Model-Based Methods in the Biopharmaceutical Process Lifecycle

Kröll, Paul; Hofer, Alexandra; Ulonska, Sophia et al. · 2017 · Pharmaceutical Research · DOI

Full title: Model-Based Methods in the Biopharmaceutical Process Lifecycle

Authors: Kröll, Paul; Hofer, Alexandra; Ulonska, Sophia; Kager, Julian; Herwig, Christoph

Year: 2017

Venue: Pharmaceutical Research

DOI: https://doi.org/10.1007/s11095-017-2308-y

Paper Monitoring and modelling the glutamine metabolic pathway: a review and future perspectives

Mirveis, Zohreh; Howe, Orla; Cahill, Paul A. et al. · 2023 · Metabolomics · DOI

Full title: Monitoring and modelling the glutamine metabolic pathway: a review and future perspectives

Authors: Mirveis, Zohreh; Howe, Orla; Cahill, Paul A.; Patil, Nitin; Byrne, Hugh J.

Year: 2023

Venue: Metabolomics

DOI: https://doi.org/10.1007/s11306-023-02031-9

Paper Enhancing analytical sensitivity in upstream bioprocess using time-gated Raman spectroscopy.

Shaikat, Mahdi Mubin; Dhara, Venkata Gayatri; Drennen, James K et al. · 2026 · Bioprocess and biosystems engineering · DOI

Full title: Enhancing analytical sensitivity in upstream bioprocess using time-gated Raman spectroscopy.

Authors: Shaikat, Mahdi Mubin; Dhara, Venkata Gayatri; Drennen, James K; Dong, Guogang; Anderson, Carl A

Year: 2026

Venue: Bioprocess and biosystems engineering

DOI: https://doi.org/10.1007/s00449-025-03261-y

Paper Spectroscopic-Based Prediction of Milk Foam Properties for Barista Applications

Brettschneider, Kim; Zettel, Viktoria; Vasafi, Pegah Sadeghi et al. · 2022 · Food and Bioprocess Technology · DOI

Full title: Spectroscopic-Based Prediction of Milk Foam Properties for Barista Applications

Authors: Brettschneider, Kim; Zettel, Viktoria; Vasafi, Pegah Sadeghi; Hummel, Darius; Hinrichs, Jörg; Hitzmann, Bernd

Year: 2022

Venue: Food and Bioprocess Technology

DOI: https://doi.org/10.1007/s11947-022-02822-3

Paper Metabolic analysis of the response of Pseudomonas putida DOT-T1E strains to toluene using Fourier transform infrared spectroscopy and gas chromatography mass spectrometry

Sayqal, Ali; Xu, Yun; Trivedi, Drupad K. et al. · 2016 · Metabolomics · DOI

Full title: Metabolic analysis of the response of Pseudomonas putida DOT-T1E strains to toluene using Fourier transform infrared spectroscopy and gas chromatography mass spectrometry

Authors: Sayqal, Ali; Xu, Yun; Trivedi, Drupad K.; AlMasoud, Najla; Ellis, David I.; Muhamadali, Howbeer; Rattray, Nicholas J. W.; Webb, Carole; Goodacre, Royston

Year: 2016

Venue: Metabolomics

DOI: https://doi.org/10.1007/s11306-016-1054-1

Paper Software sensors in the monitoring of microalgae cultivations

Reyes, Luis Porras; Havlík, I.; Beutel, Sascha · 2024 · Reviews in Environmental Science and Bio/Technology · DOI

Full title: Software sensors in the monitoring of microalgae cultivations

Authors: Reyes, Luis Porras; Havlík, I.; Beutel, Sascha

Year: 2024

Venue: Reviews in Environmental Science and Bio/Technology

DOI: https://doi.org/10.1007/s11157-023-09679-8

Paper Wanted: more monitoring and control during inclusion body processing

Humer, Diana; Spadiut, Oliver · 2018 · World Journal of Microbiology and Biotechnology · DOI

Full title: Wanted: more monitoring and control during inclusion body processing

Authors: Humer, Diana; Spadiut, Oliver

Year: 2018

Venue: World Journal of Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s11274-018-2541-5

Paper Indicators for optical oxygen sensors

Quaranta, Michela; Borisov, Sergey M.; Klimant, Ingo · 2012 · Bioanalytical reviews · DOI

Full title: Indicators for optical oxygen sensors

Authors: Quaranta, Michela; Borisov, Sergey M.; Klimant, Ingo

Year: 2012

Venue: Bioanalytical reviews

DOI: https://doi.org/10.1007/s12566-012-0032-y

Paper Methods for quantification of growth and productivity in anaerobic microbiology and biotechnology

Mauerhofer, Lisa‐Maria; Pappenreiter, Patricia; Paulik, Christian et al. · 2018 · Folia Microbiologica · DOI

Full title: Methods for quantification of growth and productivity in anaerobic microbiology and biotechnology

Authors: Mauerhofer, Lisa‐Maria; Pappenreiter, Patricia; Paulik, Christian; Seifert, Arne H.; Bernacchi, Sébastien; Rittmann, Simon K.‐M. R.

Year: 2018

Venue: Folia Microbiologica

DOI: https://doi.org/10.1007/s12223-018-0658-4

Paper A probabilistic model-based soft sensor to monitor lactic acid bacteria fermentations

R. Spann; C. Roca; David Kold et al. · 2018 · Biochemical engineering journal · DOI

Full title: A probabilistic model-based soft sensor to monitor lactic acid bacteria fermentations

Authors: R. Spann; C. Roca; David Kold; A. Lantz; K. Gernaey; G. Sin

Year: 2018

Venue: Biochemical engineering journal

DOI: https://doi.org/10.1016/j.bej.2018.03.016

Paper Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-Linked Glycosylation.

Gyorgypal, Aron; Chundawat, Shishir P S · 2022 · Analytical chemistry · DOI

Full title: Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-Linked Glycosylation.

Authors: Gyorgypal, Aron; Chundawat, Shishir P S

Year: 2022

Venue: Analytical chemistry

DOI: https://doi.org/10.1021/acs.analchem.1c05396

Paper Development of process analytical tools for rapid monitoring of live virus vaccines in manufacturing.

Yi, Sijia; McCracken, Reilly; Davide, Joseph et al. · 2022 · Scientific reports · DOI

Full title: Development of process analytical tools for rapid monitoring of live virus vaccines in manufacturing.

Authors: Yi, Sijia; McCracken, Reilly; Davide, Joseph; Salovich, Daniel Ryan; Whitmer, Travis; Bhat, Aditya; Vlasak, Josef; Ha, Sha; Sehlin, Darrell; Califano, Joseph; Ploeger, Kristin; Mukherjee, Malini

Year: 2022

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-022-19744-x

Paper Optics miniaturization strategy for demanding Raman spectroscopy applications

Ilchenko, Oleksii; Pilhun, Yurii; Kutsyk, Andrii et al. · 2024 · Nature Communications · DOI

Full title: Optics miniaturization strategy for demanding Raman spectroscopy applications

Authors: Ilchenko, Oleksii; Pilhun, Yurii; Kutsyk, Andrii; Slobodianiuk, Denys; Göksel, Yaman; Dumont, Elodie; Vaut, Lukas; Mazzoni, Chiara; Morelli, Lidia; Boisen, Sofus; Stergiou, Konstantinos I.; Aulin, Yaroslav V.; Rindzevicius, Tomas; Andersen, Thomas Emil; Lassen, Mikael; Mundhada, Hemanshu; Jendresen, Christian Bille; Philipsen, Peter A.; Hædersdal, Merete; Boisen, Anja

Year: 2024

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-024-47044-7

Paper Time-Resolved Pharmacological Studies using Automated, On-line Monitoring of Five Parallel Suspension Cultures

Alhusban, Ala A.; Breadmore, Michael C.; Gueven, Nuri et al. · 2017 · Scientific Reports · DOI

Full title: Time-Resolved Pharmacological Studies using Automated, On-line Monitoring of Five Parallel Suspension Cultures

Authors: Alhusban, Ala A.; Breadmore, Michael C.; Gueven, Nuri; Guijt, Rosanne M.

Year: 2017

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-017-10472-1

Paper Simplifying the detection and monitoring of protein glycosylation during in vitro glycoengineering

Matthew J Saunders; Robert J. Woods; Loretta Yang · 2023 · Scientific Reports · DOI

Full title: Simplifying the detection and monitoring of protein glycosylation during in vitro glycoengineering

Authors: Matthew J Saunders; Robert J. Woods; Loretta Yang

Year: 2023

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-023-27634-z

Paper Deep Learning-Powered Colloidal Digital SERS for Precise Monitoring of Cell Culture Media

Peng Zheng; Lintong Wu; Michael Ka Ho Lee et al. · 2025 · bioRxiv · DOI

Full title: Deep Learning-Powered Colloidal Digital SERS for Precise Monitoring of Cell Culture Media

Authors: Peng Zheng; Lintong Wu; Michael Ka Ho Lee; Andy Nelson; Michael J. Betenbaugh; Ishan Barman

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.02.03.636280

Paper In situ monitoring of Lentilactobacillus parabuchneri biofilm formation via real-time infrared spectroscopy

Bajrami, Diellza; Fischer, Stephan; Barth, Holger et al. · 2022 · npj Biofilms and Microbiomes · DOI

Full title: In situ monitoring of Lentilactobacillus parabuchneri biofilm formation via real-time infrared spectroscopy

Authors: Bajrami, Diellza; Fischer, Stephan; Barth, Holger; Sarquis, Agustina; Ladero, Víctor; Fernández, Marı́a; Sportelli, Maria Chiara; Cioffi, Nicola; Kranz, Christine; Mizaikoff, Boris

Year: 2022

Venue: npj Biofilms and Microbiomes

DOI: https://doi.org/10.1038/s41522-022-00353-5

Paper FTIR microspectroscopy for rapid screening and monitoring of polyunsaturated fatty acid production in commercially valuable marine yeasts and protists

Vongsvivut, Jitraporn; Heraud, Philip; Gupta, Adarsha et al. · 2013 · The Analyst · DOI

Full title: FTIR microspectroscopy for rapid screening and monitoring of polyunsaturated fatty acid production in commercially valuable marine yeasts and protists

Authors: Vongsvivut, Jitraporn; Heraud, Philip; Gupta, Adarsha; Puri, Munish; McNaughton, Don; Barrow, Colin J.

Year: 2013

Venue: The Analyst

DOI: https://doi.org/10.1039/c3an00485f

Paper Comprehensive modeling of cell culture profile using Raman spectroscopy and machine learning

Tanemura, Hiroki; Kitamura, Ryunosuke; Yamada, Yasuko et al. · 2023 · Scientific Reports · DOI

Full title: Comprehensive modeling of cell culture profile using Raman spectroscopy and machine learning

Authors: Tanemura, Hiroki; Kitamura, Ryunosuke; Yamada, Yasuko; Hoshino, M.; Kakihara, Hirofumi; Nonaka, Koichi

Year: 2023

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-023-49257-0

Paper Elucidating time-resolved intracellular metabolic dynamics via label-free Raman microspectroscopy and 2D correlation spectroscopy

Mirveis, Zohreh; Patil, Nitin; Byrne, Hugh J. · 2025 · The Analyst · DOI

Full title: Elucidating time-resolved intracellular metabolic dynamics via label-free Raman microspectroscopy and 2D correlation spectroscopy

Authors: Mirveis, Zohreh; Patil, Nitin; Byrne, Hugh J.

Year: 2025

Venue: The Analyst

DOI: https://doi.org/10.1039/d5an01114k

Paper Integration and application of optical chemical sensors in microbioreactors

Gruber, Pia; Marques, Marco P. C.; Szita, Nicolas et al. · 2017 · Lab on a Chip · DOI

Full title: Integration and application of optical chemical sensors in microbioreactors

Authors: Gruber, Pia; Marques, Marco P. C.; Szita, Nicolas; Mayr, Torsten

Year: 2017

Venue: Lab on a Chip

DOI: https://doi.org/10.1039/c7lc00538e

Paper Point-and-shoot: rapid quantitative detection methods for on-site food fraud analysis – moving out of the laboratory and into the food supply chain

Ellis, David I.; Muhamadali, Howbeer; Haughey, Simon A. et al. · 2015 · Analytical Methods · DOI

Full title: Point-and-shoot: rapid quantitative detection methods for on-site food fraud analysis – moving out of the laboratory and into the food supply chain

Authors: Ellis, David I.; Muhamadali, Howbeer; Haughey, Simon A.; Elliott, Christopher T.; Goodacre, Royston

Year: 2015

Venue: Analytical Methods

DOI: https://doi.org/10.1039/c5ay02048d

Paper Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing

Williams, Thomas J.; Kalinka, Kevin; Sanches, Rui et al. · 2023 · Scientific Reports · DOI

Full title: Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing

Authors: Williams, Thomas J.; Kalinka, Kevin; Sanches, Rui; Blanchard-Emmerson, Greg; Watts, Samuel; Davies, Lee; Knevelman, Carol; McCloskey, Laura J.; Jones, Peter B.; Mitrophanous, Kyriacos; Miskin, James; Dikicioǧlu, Duygu

Year: 2023

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-023-27998-2

Paper Deep learning-enabled Inference of 3D molecular absorption distribution of biological cells from IR spectra

Magnussen, Eirik Almklov; Zimmermann, Boris; Blazhko, Uladzislau et al. · 2022 · Communications Chemistry · DOI

Full title: Deep learning-enabled Inference of 3D molecular absorption distribution of biological cells from IR spectra

Authors: Magnussen, Eirik Almklov; Zimmermann, Boris; Blazhko, Uladzislau; Dzurendová, Simona; Dupuy-Galet, Benjamin Xavier; Byrtusová, Dana; Muthreich, Florian; Tafintseva, Valeria; Liland, Kristian Hovde; Tøndel, Kristin; Shapaval, Volha; Köhler, Achim

Year: 2022

Venue: Communications Chemistry

DOI: https://doi.org/10.1038/s42004-022-00792-3

Paper Exploration of linear and interpretable models for quantification of cell parameters via contactless short-wave infrared hyperspectral sensing

Hevaganinge, Anjana; Lowenstein, Eve J.; Filatova, Аnna et al. · 2025 · Scientific Reports · DOI

Full title: Exploration of linear and interpretable models for quantification of cell parameters via contactless short-wave infrared hyperspectral sensing

Authors: Hevaganinge, Anjana; Lowenstein, Eve J.; Filatova, Аnna; Modak, M J; Mogo, Nandi Thales; Rowley, Bryana; Yarmowsky, Jenny; Ehizibolo, Joshua; Hevaganinge, Ravidu; Musser, Amy; Ким, А. Ю.; Neri, Anthony; Conway, Jessica; Yuan, Yiding; Cattaneo, Maurizio; Tee, Sui Seng; Yang, Tao

Year: 2025

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-025-85930-2

Paper Improving the Model Migration Ability by a Hyperspectral Method With a High Spatial Resolution

Zhang, Mengqiu; Hou, Xingwei; Gang, Li et al. · 2019 · IEEE Access · DOI

Full title: Improving the Model Migration Ability by a Hyperspectral Method With a High Spatial Resolution

Authors: Zhang, Mengqiu; Hou, Xingwei; Gang, Li; Lin, Ling

Year: 2019

Venue: IEEE Access

DOI: https://doi.org/10.1109/access.2019.2955821

Paper Automated Workflow for Instant Labeling and Real-Time Monitoring of Monoclonal Antibody N-Glycosylation

Aron Gyorgypal; O. Potter; Antash Chaturvedi et al. · 2022 · bioRxiv · DOI

Full title: Automated Workflow for Instant Labeling and Real-Time Monitoring of Monoclonal Antibody N-Glycosylation

Authors: Aron Gyorgypal; O. Potter; Antash Chaturvedi; David N. Powers; S. Chundawat

Year: 2022

Venue: bioRxiv

DOI: https://doi.org/10.1101/2022.12.22.521623

Paper Automated Bioprocess Feedback Operation in a High-Throughput Facility via the Integration of a Mobile Robotic Lab Assistant

Kaspersetz, Lucas; Waldburger, Saskia; Schermeyer, Marie‐Therese et al. · 2022 · Frontiers in Chemical Engineering · DOI

Full title: Automated Bioprocess Feedback Operation in a High-Throughput Facility via the Integration of a Mobile Robotic Lab Assistant

Authors: Kaspersetz, Lucas; Waldburger, Saskia; Schermeyer, Marie‐Therese; Riedel, Sebastian L.; Groß, Sebastian; Neubauer, Peter; Bournazou, Mariano Nicolás Cruz

Year: 2022

Venue: Frontiers in Chemical Engineering

DOI: https://doi.org/10.3389/fceng.2022.812140

Paper Ultrasonic Techniques for Liquids Characterisation

Povey, Megan; Pinfield, Valerie J.; Hefft, Daniel Ingo et al. · 2025 · DOI

Full title: Ultrasonic Techniques for Liquids Characterisation

Authors: Povey, Megan; Pinfield, Valerie J.; Hefft, Daniel Ingo; Bowler, Alexander L.; Watson, Nicholas J.

Year: 2025

DOI: https://doi.org/10.1088/978-0-7503-3203-3

Paper Reaction kinetics of procainamide dye derivatization of N-linked glycans to enable robust process analytical workflows for glycoprotein-based biologics manufacturing

Nurulhuda Binte Suaini; Aditya Narvekar; S. Chundawat · 2025 · bioRxiv · DOI

Full title: Reaction kinetics of procainamide dye derivatization of N-linked glycans to enable robust process analytical workflows for glycoprotein-based biologics manufacturing

Authors: Nurulhuda Binte Suaini; Aditya Narvekar; S. Chundawat

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.10.15.682640

Paper Temporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch and Perfusion Bioreactor Operation

Aron Gyorgypal; Erica J. Fratz-Berilla; C. Kohnhorst et al. · 2023 · bioRxiv · DOI

Full title: Temporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch and Perfusion Bioreactor Operation

Authors: Aron Gyorgypal; Erica J. Fratz-Berilla; C. Kohnhorst; David N. Powers; S. Chundawat

Year: 2023

Venue: bioRxiv

DOI: https://doi.org/10.1101/2023.04.15.535602

Paper Sensor technologies for quality control in engineered tissue manufacturing

McCorry, Mary Clare; Reardon, Kenneth F.; Black, Marcie R. et al. · 2022 · Biofabrication · DOI

Full title: Sensor technologies for quality control in engineered tissue manufacturing

Authors: McCorry, Mary Clare; Reardon, Kenneth F.; Black, Marcie R.; Williams, Chrysanthi; Babakhanova, Greta; Halpern, Jeffrey Mark; Sarkar, Sumona; Swami, Nathan S.; Mirica, Katherine A.; Boermeester, Sarah; Underhill, Abbie K.

Year: 2022

Venue: Biofabrication

DOI: https://doi.org/10.1088/1758-5090/ac94a1

Paper Microalgae Lipids Detection and Quantification Method Towards Online Real-Time Monitoring: A Review

Chong, Kar Lok; Ahmad, Mohd Ridzuan · 2023 · ELEKTRIKA- Journal of Electrical Engineering · DOI

Full title: Microalgae Lipids Detection and Quantification Method Towards Online Real-Time Monitoring: A Review

Authors: Chong, Kar Lok; Ahmad, Mohd Ridzuan

Year: 2023

Venue: ELEKTRIKA- Journal of Electrical Engineering

DOI: https://doi.org/10.11113/elektrika.v22n3.454

Paper Deep Learning-Powered Colloidal Digital SERS for Precise Monitoring of Cell Culture Media

Peng Zheng; Lintong Wu; Michael Ka Ho Lee et al. · 2025 · bioRxiv · DOI

Full title: Deep Learning-Powered Colloidal Digital SERS for Precise Monitoring of Cell Culture Media

Authors: Peng Zheng; Lintong Wu; Michael Ka Ho Lee; Andy Nelson; Michael J. Betenbaugh; Ishan Barman

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.02.03.636280

Paper REAL-TIME AT-LINE MONITORING OF INFLUENZA VIRUS IN CELL CULTURE BY A SURFACE PLASMON RESONANCE BIOSENSOR

Durous, Laurent; Padey, Blandine; Traversier, Aurélien et al. · 2023 · DOI

Full title: REAL-TIME AT-LINE MONITORING OF INFLUENZA VIRUS IN CELL CULTURE BY A SURFACE PLASMON RESONANCE BIOSENSOR

Authors: Durous, Laurent; Padey, Blandine; Traversier, Aurélien; Chupin, Caroline; Julien, Thomas; Blum, Loı̈c J.; Marquette, Christophe A.; Rosa‐Calatrava, Manuel; Petiot, Emma

Year: 2023

DOI: https://doi.org/10.1101/2023.03.16.532923

Paper Review of multidimensional data processing approaches for Raman and infrared spectroscopy

Gautam, Rekha; Vanga, Sandeep; Ariese, Freek et al. · 2015 · EPJ Techniques and Instrumentation · DOI

Full title: Review of multidimensional data processing approaches for Raman and infrared spectroscopy

Authors: Gautam, Rekha; Vanga, Sandeep; Ariese, Freek; Umapathy, Siva

Year: 2015

Venue: EPJ Techniques and Instrumentation

DOI: https://doi.org/10.1140/epjti/s40485-015-0018-6

Paper Quantificação óptica de carboidratos e etanol em mosto cervejeiro

Estracanholli, Éverton Sérgio · 2012 · Prof. Dr. · DOI

Full title: Quantificação óptica de carboidratos e etanol em mosto cervejeiro

Authors: Estracanholli, Éverton Sérgio

Year: 2012

Venue: Prof. Dr.

DOI: https://doi.org/10.11606/t.76.2012.tde-17122012-150125

Paper Real-time and on-line monitoring of ethanol fermentation process by viable cell sensor and electronic nose

Feng, Yao; Tian, Xiwei; Chen, Yang et al. · 2021 · Bioresources and Bioprocessing · DOI

Full title: Real-time and on-line monitoring of ethanol fermentation process by viable cell sensor and electronic nose

Authors: Feng, Yao; Tian, Xiwei; Chen, Yang; Wang, Zeyu; Xia, Jianye; Qian, Jiangchao; Zhuang, Yingping; Chu, Ju

Year: 2021

Venue: Bioresources and Bioprocessing

DOI: https://doi.org/10.1186/s40643-021-00391-5

Paper Improvement of bioprocess monitoring: development of novel concepts

Clementschitsch, Franz; Bayer, Karl · 2006 · Microbial Cell Factories · DOI

Full title: Improvement of bioprocess monitoring: development of novel concepts

Authors: Clementschitsch, Franz; Bayer, Karl

Year: 2006

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-5-19

Paper A dynamic method for the investigation of induced state metabolic capacities as a function of temperature

Sagmeister, Patrick; Langemann, Timo; Wechselberger, Patrick et al. · 2013 · Microbial Cell Factories · DOI

Full title: A dynamic method for the investigation of induced state metabolic capacities as a function of temperature

Authors: Sagmeister, Patrick; Langemann, Timo; Wechselberger, Patrick; Meitz, Andrea; Herwig, Christoph

Year: 2013

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-12-94

Paper Towards better understanding of an industrial cell factory: investigating the feasibility of real-time metabolic flux analysis in Pichia pastoris

Fazenda, Mariana L.; Dias, João M.L.; Harvey, Linda M. et al. · 2013 · Microbial Cell Factories · DOI

Full title: Towards better understanding of an industrial cell factory: investigating the feasibility of real-time metabolic flux analysis in Pichia pastoris

Authors: Fazenda, Mariana L.; Dias, João M.L.; Harvey, Linda M.; Nordon, Alison; Edrada‐Ebel, RuAngelie; Littlejohn, David; McNeil, Brian

Year: 2013

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-12-51

Paper Raman spectroscopy online monitoring of biomass production, intracellular metabolites and carbon substrates during submerged fermentation of oleaginous and carotenogenic microorganisms.

Dzurendova, Simona; Olsen, Pernille Margrethe; Byrtusová, Dana et al. · 2023 · Microbial cell factories · DOI

Full title: Raman spectroscopy online monitoring of biomass production, intracellular metabolites and carbon substrates during submerged fermentation of oleaginous and carotenogenic microorganisms.

Authors: Dzurendova, Simona; Olsen, Pernille Margrethe; Byrtusová, Dana; Tafintseva, Valeria; Shapaval, Volha; Horn, Svein Jarle; Kohler, Achim; Szotkowski, Martin; Marova, Ivana; Zimmermann, Boris

Year: 2023

Venue: Microbial cell factories

DOI: https://doi.org/10.1186/s12934-023-02268-y

Paper Application of near-infrared spectroscopy technology in the complex fermentation system to achieve high-efficiency production

Chen, Yang; Lingli, Chen; Guo, Meijin et al. · 2021 · Bioresources and Bioprocessing · DOI

Full title: Application of near-infrared spectroscopy technology in the complex fermentation system to achieve high-efficiency production

Authors: Chen, Yang; Lingli, Chen; Guo, Meijin; Xu, Li; Liu, Jinsong; Liu, Xiaofeng; Chen, Zhongbing; Tian, Xiaojun; Zheng, Haoyue; Tian, Xiwei; Chu, Ju; Zhuang, Yingping

Year: 2021

Venue: Bioresources and Bioprocessing

DOI: https://doi.org/10.1186/s40643-021-00452-9

Paper Metabolomics investigation of recombinant mTNFα production in Streptomyces lividans

Muhamadali, Howbeer; Xu, Yun; Ellis, David I. et al. · 2015 · Microbial Cell Factories · DOI

Full title: Metabolomics investigation of recombinant mTNFα production in Streptomyces lividans

Authors: Muhamadali, Howbeer; Xu, Yun; Ellis, David I.; Trivedi, Drupad K.; Rattray, Nicholas J. W.; Bernaerts, Kristel; Goodacre, Royston

Year: 2015

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-015-0350-1

Paper Metabolomics Analysis Reveals the Participation of Efflux Pumps and Ornithine in the Response of Pseudomonas putida DOT-T1E Cells to Challenge with Propranolol

Sayqal, Ali; Xu, Yun; Trivedi, Drupad K. et al. · 2016 · PLoS ONE · DOI

Full title: Metabolomics Analysis Reveals the Participation of Efflux Pumps and Ornithine in the Response of Pseudomonas putida DOT-T1E Cells to Challenge with Propranolol

Authors: Sayqal, Ali; Xu, Yun; Trivedi, Drupad K.; AlMasoud, Najla; Ellis, David I.; Rattray, Nicholas J. W.; Goodacre, Royston

Year: 2016

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0156509

Paper Prediction Performance and Economic Efficiency of Soft Sensors for in-Line Water Content Monitoring in Fluidized Bed Granulation: PP-Based Model vs. NIRS-Based Model.

Yaginuma, Keita; Tanabe, Shuichi; Sugiyama, Hirokazu et al. · 2021 · Chemical & pharmaceutical bulletin · DOI

Full title: Prediction Performance and Economic Efficiency of Soft Sensors for in-Line Water Content Monitoring in Fluidized Bed Granulation: PP-Based Model vs. NIRS-Based Model.

Authors: Yaginuma, Keita; Tanabe, Shuichi; Sugiyama, Hirokazu; Kano, Manabu

Year: 2021

Venue: Chemical & pharmaceutical bulletin

DOI: https://doi.org/10.1248/cpb.c20-01016

Paper Lipids detection and quantification in oleaginous microorganisms: an overview of the current state of the art

Patel, Alok; Antonopoulou, Io; Enman, Josefine et al. · 2019 · BMC Chemical Engineering · DOI

Full title: Lipids detection and quantification in oleaginous microorganisms: an overview of the current state of the art

Authors: Patel, Alok; Antonopoulou, Io; Enman, Josefine; Rova, Ulrika; Christakopoulos, Paul; Μάτσακας, Λεωνίδας

Year: 2019

Venue: BMC Chemical Engineering

DOI: https://doi.org/10.1186/s42480-019-0013-9

Paper Machine Learning-Enabled NIR Spectroscopy. Part 3: Hyperparameter by Design (HyD) Based ANN-MLP Optimization, Model Generalizability, and Model Transferability

Ali, Hussain; Muthudoss, Prakash; Chauhan, Chirag et al. · 2023 · AAPS PharmSciTech · DOI

Full title: Machine Learning-Enabled NIR Spectroscopy. Part 3: Hyperparameter by Design (HyD) Based ANN-MLP Optimization, Model Generalizability, and Model Transferability

Authors: Ali, Hussain; Muthudoss, Prakash; Chauhan, Chirag; Ilango, K.; Kumar, Dinesh; Paudel, Amrit; Ramasamy, Gobi

Year: 2023

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-023-02697-3

Paper Improved production of polysaccharides in Ganoderma lingzhi mycelia by plasma mutagenesis and rapid screening of mutated strains through infrared spectroscopy

Ma, Yuhan; Zhang, Qianqian; Zhang, Qifu et al. · 2018 · PLoS ONE · DOI

Full title: Improved production of polysaccharides in Ganoderma lingzhi mycelia by plasma mutagenesis and rapid screening of mutated strains through infrared spectroscopy

Authors: Ma, Yuhan; Zhang, Qianqian; Zhang, Qifu; Hua-qi, HE; Chen, Zhu; Zhao, Yan; Wei, Da; Kong, Mingguang; Huang, Qing

Year: 2018

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0204266

Paper Quantitative Comparison and Clustering of Circular Dichroism Spectra Using a Symmetrized Weighted Spectral Difference

Chouchane, Karim; Kirkitadze, Marina; Misra, Rahul et al. · 2024 · The AAPS Journal · DOI

Full title: Quantitative Comparison and Clustering of Circular Dichroism Spectra Using a Symmetrized Weighted Spectral Difference

Authors: Chouchane, Karim; Kirkitadze, Marina; Misra, Rahul; Kowal, Przemysław; Dalloz-bourguignon, Olivier; Greco, Frédéric; Fayard, Sylvie; Marco, Sergio; Clénet, Didier

Year: 2024

Venue: The AAPS Journal

DOI: https://doi.org/10.1208/s12248-024-01005-6

Paper Application of vibrational spectroscopies as process analytical techniques for monitoring fermentation and the conversion of lignocellulosic biomass by oleaginous filamentous fungi

Dzurendová, Simona; Losada, Cristian Bolaño; Dupuy-Galet, Benjamin Xavier et al. · 2025 · Microbial Cell Factories · DOI

Full title: Application of vibrational spectroscopies as process analytical techniques for monitoring fermentation and the conversion of lignocellulosic biomass by oleaginous filamentous fungi

Authors: Dzurendová, Simona; Losada, Cristian Bolaño; Dupuy-Galet, Benjamin Xavier; Slaný, Ondrej; Fjær, Kai; Bartolomeo, Francesca Di; Markussen, Sidsel; Wentzel, Alexander; Várnai, Anikó; Hansen, Line Degn; Horn, Svein Jarle; Köhler, Achim; Shapaval, Volha; Zimmermann, Boris

Year: 2025

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-025-02868-w

Paper Gray-box Soft Sensor for Water Content Monitoring in Fluidized Bed Granulation.

Yaginuma, Keita; Tanabe, Shuichi; Kano, Manabu · 2022 · Chemical & pharmaceutical bulletin · DOI

Full title: Gray-box Soft Sensor for Water Content Monitoring in Fluidized Bed Granulation.

Authors: Yaginuma, Keita; Tanabe, Shuichi; Kano, Manabu

Year: 2022

Venue: Chemical & pharmaceutical bulletin

DOI: https://doi.org/10.1248/cpb.c21-00777

Paper Recent applications of quantitative analytical FTIR spectroscopy in pharmaceutical, biomedical, and clinical fields: A brief review

Fahelelbom, Khairi Mustafa; Saleh, Abdullah; Al-Tabakha, Moawia M. et al. · 2022 · Reviews in Analytical Chemistry · DOI

Full title: Recent applications of quantitative analytical FTIR spectroscopy in pharmaceutical, biomedical, and clinical fields: A brief review

Authors: Fahelelbom, Khairi Mustafa; Saleh, Abdullah; Al-Tabakha, Moawia M.; Ashames, Akram

Year: 2022

Venue: Reviews in Analytical Chemistry

DOI: https://doi.org/10.1515/revac-2022-0030

Paper - **Authors:** Y. Havrylko, O. A. Kurchenko, I. Tereshchenko, A. Tereshchenko - **Year:** 2019 - **Journal:** Radio Electronics, Computer Science, Control - **Source:** semanticscholar

Y. Havrylko; O. A. Kurchenko; I. Tereshchenko et al. · 2019 · Radio Electronics, Computer Science, Control · DOI

Full title: - **Authors:** Y. Havrylko, O. A. Kurchenko, I. Tereshchenko, A. Tereshchenko - **Year:** 2019 - **Journal:** Radio Electronics, Computer Science, Control - **Source:** semanticscholar

Authors: Y. Havrylko; O. A. Kurchenko; I. Tereshchenko; A. Tereshchenko

Year: 2019

Venue: Radio Electronics, Computer Science, Control

DOI: https://doi.org/10.15588/1607-3274-2019-1-16

Paper Entwicklung und Charakterisierung eines neuen Fluoreszenzsensors für die online-Überwachung von Bioprozessen

König, Jan Christoph · 2019 · Institutional Repository of Leibniz Universität Hannover (Leibniz Universität Hannover) · DOI

Full title: Entwicklung und Charakterisierung eines neuen Fluoreszenzsensors für die online-Überwachung von Bioprozessen

Authors: König, Jan Christoph

Year: 2019

Venue: Institutional Repository of Leibniz Universität Hannover (Leibniz Universität Hannover)

DOI: https://doi.org/10.15488/4864

Paper Fourier-transform infrared spectroscopy and machine learning to predict amino acid content of nine commercial insects

Hou, Yinchen; Zhao, Penghui; Zhang, Fan et al. · 2022 · Food Science and Technology · DOI

Full title: Fourier-transform infrared spectroscopy and machine learning to predict amino acid content of nine commercial insects

Authors: Hou, Yinchen; Zhao, Penghui; Zhang, Fan; Yang, Shengru; Rady, Ahmed; Wijewardane, Nuwan K.; Huang, Jihong; Li, Mengxing

Year: 2022

Venue: Food Science and Technology

DOI: https://doi.org/10.1590/fst.100821

Paper Use of Raman spectroscopy for continuous monitoring and control of lignocellulosic biorefinery processes

Ewanick, Shannon; Schmitt, Elliott; Gustafson, Rick et al. · 2014 · Pure and Applied Chemistry · DOI

Full title: Use of Raman spectroscopy for continuous monitoring and control of lignocellulosic biorefinery processes

Authors: Ewanick, Shannon; Schmitt, Elliott; Gustafson, Rick; Bura, Renata

Year: 2014

Venue: Pure and Applied Chemistry

DOI: https://doi.org/10.1515/pac-2013-1022

Paper Phenotypic and Metabolic profiling of Biological Samples in Near Real-Time using Raman Spectroscopy

Zu, Theresah Nom Korbieh · 2014 · VTechWorks (Virginia Tech) · DOI

Full title: Phenotypic and Metabolic profiling of Biological Samples in Near Real-Time using Raman Spectroscopy

Authors: Zu, Theresah Nom Korbieh

Year: 2014

Venue: VTechWorks (Virginia Tech)

DOI: https://doi.org/10.13140/rg.2.1.4373.3368

Paper Overview: flexible and versatile approach of quality by design & process analytical technology in industries

Kutty, Razia; Nikam, Machindra; Chaudhari, Sakshi et al. · 2024 · Journal of Pharmaceutical and Biological Sciences · DOI

Full title: Overview: flexible and versatile approach of quality by design & process analytical technology in industries

Authors: Kutty, Razia; Nikam, Machindra; Chaudhari, Sakshi; Shinde, Chetana; Gadakh, Priya; Niphade, Pooja Shankar; Kakad, A.

Year: 2024

Venue: Journal of Pharmaceutical and Biological Sciences

DOI: https://doi.org/10.18231/j.jpbs.2023.014

Paper Raman Spectroscopy for Quantitative Analysis in the Pharmaceutical Industry

Jesus, José Izo Santana da Silva de; Löbenberg, Raimar; Bou‐Chacra, Nádia Araci · 2020 · Journal of Pharmacy & Pharmaceutical Sciences · DOI

Full title: Raman Spectroscopy for Quantitative Analysis in the Pharmaceutical Industry

Authors: Jesus, José Izo Santana da Silva de; Löbenberg, Raimar; Bou‐Chacra, Nádia Araci

Year: 2020

Venue: Journal of Pharmacy & Pharmaceutical Sciences

DOI: https://doi.org/10.18433/jpps30649

Paper Enhanced optical detection of chemical and biological species with volume-shrinkable hydrogel and AI-assisted spectrum analysis

Zheng, Yiting · 2023 · DOI

Full title: Enhanced optical detection of chemical and biological species with volume-shrinkable hydrogel and AI-assisted spectrum analysis

Authors: Zheng, Yiting

Year: 2023

DOI: https://doi.org/10.17760/d20487149

Paper Co-clustering the data of multivariate quality attributes for the estimation of mutual influence factors

S. Shtangey; I. Tereshchenko; A. Tereshchenko · 2018 · Bulletin of the National Technical University «KhPI» Series New solutions in modern technologies · DOI

Full title: Co-clustering the data of multivariate quality attributes for the estimation of mutual influence factors

Authors: S. Shtangey; I. Tereshchenko; A. Tereshchenko

Year: 2018

Venue: Bulletin of the National Technical University «KhPI» Series New solutions in modern technologies

DOI: https://doi.org/10.20998/2413-4295.2018.26.31

Paper Digital Twin Technology and Process Validation in Pharmaceutical Manufacturing:Bridging Virtual Simulation and Regulatory Compliance for Next-Generation Drug Production

Patel, B. V.; Pacha, Nageswara; Patel, Jayminkumar et al. · 2026 · Preprints.org · DOI

Full title: Digital Twin Technology and Process Validation in Pharmaceutical Manufacturing:Bridging Virtual Simulation and Regulatory Compliance for Next-Generation Drug Production

Authors: Patel, B. V.; Pacha, Nageswara; Patel, Jayminkumar; Singh, Abhishek

Year: 2026

Venue: Preprints.org

DOI: https://doi.org/10.20944/preprints202602.1643.v1

Paper Developing Magnetic Resonance Based Analytics to Support Continuous Bioprocess

Legrand, Cloe · 2020 · Apollo (University of Cambridge) · DOI

Full title: Developing Magnetic Resonance Based Analytics to Support Continuous Bioprocess

Authors: Legrand, Cloe

Year: 2020

Venue: Apollo (University of Cambridge)

DOI: https://doi.org/10.17863/cam.64745

Paper Raman-guided Sample Subset Selection for Cost-efficient Offline Calibration in Bioprocesses

Wilms, Terrance; Schwenke, Fabian; King, Rudibert et al. · 2026 · DOI

Full title: Raman-guided Sample Subset Selection for Cost-efficient Offline Calibration in Bioprocesses

Authors: Wilms, Terrance; Schwenke, Fabian; King, Rudibert; Knorn, Steffi

Year: 2026

DOI: https://doi.org/10.21203/rs.3.rs-8990237/v1

Paper Prediction of citral superficial content on microparticles by NIR spectroscopy and partial least square regression

Yoplac, Ives; Ávila-George, Himer; Delgado, Luis Fernando Vargas et al. · 2019 · Revista Tecnica De La Facultad De Ingenieria Universidad Del Zulia · DOI

Full title: Prediction of citral superficial content on microparticles by NIR spectroscopy and partial least square regression

Authors: Yoplac, Ives; Ávila-George, Himer; Delgado, Luis Fernando Vargas; Robert, Paz; Castro, Wilson; Vargas, L.; Perú, Facultad de Industrias Alimentarias, Universidad Nacional Agraria La Molina,; Robert, P.; Chile, Dpto. Ciencia de los Alimentos y Tecnología Química, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de; Castro, W.; Perú, Facultad de Ingeniería, Universidad privada del Norte, Cajamarca,

Year: 2019

Venue: Revista Tecnica De La Facultad De Ingenieria Universidad Del Zulia

DOI: https://doi.org/10.22209/rt.v42n2a04

Paper Quantitative analysis of glucose in whole blood using FT-Raman spectroscopy and artificial neural network

Wang, Qiaoyun; Zheng, Nianzu; Li, Zhigang et al. · 2015 · Advances in computer science research · DOI

Full title: Quantitative analysis of glucose in whole blood using FT-Raman spectroscopy and artificial neural network

Authors: Wang, Qiaoyun; Zheng, Nianzu; Li, Zhigang; Ma, Zhenhe

Year: 2015

Venue: Advances in computer science research

DOI: https://doi.org/10.2991/iccse-15.2015.87

Paper Investigation of Differences in the Cultivation of Nannochloropsis and Chlorella species by Fourier-transform Infrared Spectroscopy

Kiss, Bernadett; Gergely, Szilveszter; Salgó, András et al. · 2018 · Periodica Polytechnica Chemical Engineering · DOI

Full title: Investigation of Differences in the Cultivation of Nannochloropsis and Chlorella species by Fourier-transform Infrared Spectroscopy

Authors: Kiss, Bernadett; Gergely, Szilveszter; Salgó, András; Németh, Áron

Year: 2018

Venue: Periodica Polytechnica Chemical Engineering

DOI: https://doi.org/10.3311/ppch.12863

Paper Quality-by-design in pharmaceutical development: From current perspectives to practical applications.

Kovács, Béla; Péterfi, Orsolya; Kovács-Deák, Boglárka et al. · 2021 · Acta pharmaceutica (Zagreb, Croatia) · DOI

Full title: Quality-by-design in pharmaceutical development: From current perspectives to practical applications.

Authors: Kovács, Béla; Péterfi, Orsolya; Kovács-Deák, Boglárka; Székely-Szentmiklósi, István; Fülöp, Ibolya; Bába, László-István; Boda, Francisc

Year: 2021

Venue: Acta pharmaceutica (Zagreb, Croatia)

DOI: https://doi.org/10.2478/acph-2021-0039

Paper Emerging analytical tools for biopharmaceuticals: A critical review of cutting-edge technologies

Patel, Rakesh; Patel, Ankur · 2024 · International Journal of Science and Research Archive · DOI

Full title: Emerging analytical tools for biopharmaceuticals: A critical review of cutting-edge technologies

Authors: Patel, Rakesh; Patel, Ankur

Year: 2024

Venue: International Journal of Science and Research Archive

DOI: https://doi.org/10.30574/ijsra.2024.12.2.1345

Paper - **Authors:** Є. В. Гаврилко, Олег Анастасійович Курченко, Ігор Володимирович Терещенко, Антон Ігорович Терещенко - **Year:** 2018 - **Journal:** N/A - **Source:** semanticscholar

Є. В. Гаврилко; Олег Анастасійович Курченко; Ігор Володимирович Терещенко et al. · 2018 · DOI

Full title: - **Authors:** Є. В. Гаврилко, Олег Анастасійович Курченко, Ігор Володимирович Терещенко, Антон Ігорович Терещенко - **Year:** 2018 - **Journal:** N/A - **Source:** semanticscholar

Authors: Є. В. Гаврилко; Олег Анастасійович Курченко; Ігор Володимирович Терещенко; Антон Ігорович Терещенко

Year: 2018

DOI: https://doi.org/10.30837/2522-9818.2018.5.005

Paper Multivariate Analysis for the Processing of Signals

Beattie, J. Renwick · 2014 · Oil & Gas Science and Technology – Revue d’IFP Energies nouvelles · DOI

Full title: Multivariate Analysis for the Processing of Signals

Authors: Beattie, J. Renwick

Year: 2014

Venue: Oil & Gas Science and Technology – Revue d’IFP Energies nouvelles

DOI: https://doi.org/10.2516/ogst/2013185

Paper Raman spectroscopy for multiplexed protein detection in tissue bioreactors

Perlaki, Clint Michael · 2017 · DOI

Full title: Raman spectroscopy for multiplexed protein detection in tissue bioreactors

Authors: Perlaki, Clint Michael

Year: 2017

DOI: https://doi.org/10.32657/10356/72388

Paper Calibration-free PAT: Locating selective crystallization or precipitation sweet spot in screenings with multi-way PARAFAC models

Wegner, Christina H.; Hubbuch, Jürgen · 2022 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Calibration-free PAT: Locating selective crystallization or precipitation sweet spot in screenings with multi-way PARAFAC models

Authors: Wegner, Christina H.; Hubbuch, Jürgen

Year: 2022

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2022.1051129

Paper Challenges in the Development of Soft Sensors for Bioprocesses: A Critical Review

Brunner, Vincent; Siegl, Manuel; Geier, Dominik et al. · 2021 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Challenges in the Development of Soft Sensors for Bioprocesses: A Critical Review

Authors: Brunner, Vincent; Siegl, Manuel; Geier, Dominik; Becker, Thomas

Year: 2021

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2021.722202

Paper Raman-based PAT for multi-attribute monitoring during VLP recovery by dual-stage CFF: attribute-specific spectral preprocessing for model transfer.

Dietrich, Annabelle; Heim, Luca; Hubbuch, Jürgen · 2025 · Frontiers in bioengineering and biotechnology · DOI

Full title: Raman-based PAT for multi-attribute monitoring during VLP recovery by dual-stage CFF: attribute-specific spectral preprocessing for model transfer.

Authors: Dietrich, Annabelle; Heim, Luca; Hubbuch, Jürgen

Year: 2025

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2025.1631807

Paper Industrializing Autologous Adoptive Immunotherapies: Manufacturing Advances and Challenges

Iyer, R.; Bowles, Paul A.; Kim, Howard S. et al. · 2018 · Frontiers in Medicine · DOI

Full title: Industrializing Autologous Adoptive Immunotherapies: Manufacturing Advances and Challenges

Authors: Iyer, R.; Bowles, Paul A.; Kim, Howard S.; Dulgar-Tulloch, Aaron

Year: 2018

Venue: Frontiers in Medicine

DOI: https://doi.org/10.3389/fmed.2018.00150

Paper Spectroscopic insights into multi-phase protein crystallization in complex lysate using Raman spectroscopy and a particle-free bypass

Wegner, Christina H.; Eming, Sebastian Mathis; Walla, Brigitte et al. · 2024 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Spectroscopic insights into multi-phase protein crystallization in complex lysate using Raman spectroscopy and a particle-free bypass

Authors: Wegner, Christina H.; Eming, Sebastian Mathis; Walla, Brigitte; Bischoff, Daniel; Weuster‐Botz, Dirk; Hubbuch, Jürgen

Year: 2024

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2024.1397465

Paper Evaluating Lignocellulosic Biomass, Its Derivatives, and Downstream Products with Raman Spectroscopy

Lupoi, Jason S.; Gjersing, Erica; Davis, Mark F. · 2015 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Evaluating Lignocellulosic Biomass, Its Derivatives, and Downstream Products with Raman Spectroscopy

Authors: Lupoi, Jason S.; Gjersing, Erica; Davis, Mark F.

Year: 2015

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2015.00050

Paper Bioprocess monitoring applications of an innovative ATR-FTIR spectroscopy platform

Christie, Loren; Rutherford, Samantha H.; Palmer, David Scott et al. · 2024 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Bioprocess monitoring applications of an innovative ATR-FTIR spectroscopy platform

Authors: Christie, Loren; Rutherford, Samantha H.; Palmer, David Scott; Baker, Matthew J.; Butler, Holly J.

Year: 2024

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2024.1349473

Paper Advancement of sensor technology for monitoring and control of upstream bioprocesses

Randek, Judit · 2020 · Linköping studies in science and technology. Dissertations · DOI

Full title: Advancement of sensor technology for monitoring and control of upstream bioprocesses

Authors: Randek, Judit

Year: 2020

Venue: Linköping studies in science and technology. Dissertations

DOI: https://doi.org/10.3384/diss.diva-165116

Paper Recent Developments in Bioprocessing of Recombinant Proteins: Expression Hosts and Process Development

Tripathi, Nagesh K.; Shrivastava, Ambuj · 2019 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Recent Developments in Bioprocessing of Recombinant Proteins: Expression Hosts and Process Development

Authors: Tripathi, Nagesh K.; Shrivastava, Ambuj

Year: 2019

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2019.00420

Paper A Lightweight convolutional neural network for nicotine prediction in tobacco by near-infrared spectroscopy

Wang, Di; Zhao, Fengyuan; Wang, Rui et al. · 2023 · Frontiers in Plant Science · DOI

Full title: A Lightweight convolutional neural network for nicotine prediction in tobacco by near-infrared spectroscopy

Authors: Wang, Di; Zhao, Fengyuan; Wang, Rui; Guo, Junwei; Zhang, Cihai; Liu, Huimin; Wang, Yongsheng; Zong, Guohao; Zhao, Le; Feng, Weihua

Year: 2023

Venue: Frontiers in Plant Science

DOI: https://doi.org/10.3389/fpls.2023.1138693

Paper Automated Bioprocess Feedback Operation in a High-Throughput Facility via the Integration of a Mobile Robotic Lab Assistant

Kaspersetz, Lucas; Waldburger, Saskia; Schermeyer, Marie‐Therese et al. · 2022 · Frontiers in Chemical Engineering · DOI

Full title: Automated Bioprocess Feedback Operation in a High-Throughput Facility via the Integration of a Mobile Robotic Lab Assistant

Authors: Kaspersetz, Lucas; Waldburger, Saskia; Schermeyer, Marie‐Therese; Riedel, Sebastian L.; Groß, Sebastian; Neubauer, Peter; Bournazou, Mariano Nicolás Cruz

Year: 2022

Venue: Frontiers in Chemical Engineering

DOI: https://doi.org/10.3389/fceng.2022.812140

Paper Deep neural network for prediction and control of permeability decline in single pass tangential flow ultrafiltration in continuous processing of monoclonal antibodies

Jesubalan, Naveen G.; Thakur, Garima; Rathore, Anurag S. · 2023 · Frontiers in Chemical Engineering · DOI

Full title: Deep neural network for prediction and control of permeability decline in single pass tangential flow ultrafiltration in continuous processing of monoclonal antibodies

Authors: Jesubalan, Naveen G.; Thakur, Garima; Rathore, Anurag S.

Year: 2023

Venue: Frontiers in Chemical Engineering

DOI: https://doi.org/10.3389/fceng.2023.1182817

Paper Raman-based PAT for VLP precipitation: systematic data diversification and preprocessing pipeline identification

Dietrich, Annabelle; Schiemer, Robin; Kurmann, Jasper et al. · 2024 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Raman-based PAT for VLP precipitation: systematic data diversification and preprocessing pipeline identification

Authors: Dietrich, Annabelle; Schiemer, Robin; Kurmann, Jasper; Zhang, Shiqi; Hubbuch, Jürgen

Year: 2024

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2024.1399938

Paper Portable Analytical Techniques for Monitoring Volatile Organic Chemicals in Biomanufacturing Processes: Recent Advances and Limitations

Chen, Xiaofeng; Hu, Runmen; Hu, Luoyu et al. · 2020 · Frontiers in Chemistry · DOI

Full title: Portable Analytical Techniques for Monitoring Volatile Organic Chemicals in Biomanufacturing Processes: Recent Advances and Limitations

Authors: Chen, Xiaofeng; Hu, Runmen; Hu, Luoyu; Huang, Yingcan; Shi, Wenyang; Wei, Qingshan; Li, Zheng

Year: 2020

Venue: Frontiers in Chemistry

DOI: https://doi.org/10.3389/fchem.2020.00837

Paper Synchronization-Free Multivariate Statistical Process Control for Online Monitoring of Batch Process Evolution

Oliveira, Rodrigo Rocha de; Juan, Anna de · 2022 · Frontiers in Analytical Science · DOI

Full title: Synchronization-Free Multivariate Statistical Process Control for Online Monitoring of Batch Process Evolution

Authors: Oliveira, Rodrigo Rocha de; Juan, Anna de

Year: 2022

Venue: Frontiers in Analytical Science

DOI: https://doi.org/10.3389/frans.2021.772844

Paper Applications of Fourier Transform-Infrared spectroscopy in microbial cell biology and environmental microbiology: advances, challenges, and future perspectives

Kassem, Amin; Abbas, Lana; Coutinho, Oliver A et al. · 2023 · Frontiers in Microbiology · DOI

Full title: Applications of Fourier Transform-Infrared spectroscopy in microbial cell biology and environmental microbiology: advances, challenges, and future perspectives

Authors: Kassem, Amin; Abbas, Lana; Coutinho, Oliver A; Opara, Somie; Najaf, Hawraa; Kasperek, Diana; Pokhrel, Keshav; Li, Xiaohua; Tiquia-Arashiro, Sonia M.

Year: 2023

Venue: Frontiers in Microbiology

DOI: https://doi.org/10.3389/fmicb.2023.1304081

Paper Estimating Extrinsic Dyes for Fluorometric Online Monitoring of Antibody Aggregation in CHO Fed-Batch Cultivations

Schwab, Karen; Hesse, Friedemann · 2017 · Bioengineering · DOI

Full title: Estimating Extrinsic Dyes for Fluorometric Online Monitoring of Antibody Aggregation in CHO Fed-Batch Cultivations

Authors: Schwab, Karen; Hesse, Friedemann

Year: 2017

Venue: Bioengineering

DOI: https://doi.org/10.3390/bioengineering4030065

Paper Opportunities in optical and electrical single-cell technologies to study microbial ecosystems

Mermans, Fabian; Mattelin, Valérie; Eeckhoudt, Ruben Van den et al. · 2023 · Frontiers in Microbiology · DOI

Full title: Opportunities in optical and electrical single-cell technologies to study microbial ecosystems

Authors: Mermans, Fabian; Mattelin, Valérie; Eeckhoudt, Ruben Van den; García‐Timermans, Cristina; Landuyt, Josefien Van; Guo, Yuting; Taurino, Irene; Tavernier, Filip; Kraft, Michaël; Khan, Hira; Boon, Nico

Year: 2023

Venue: Frontiers in Microbiology

DOI: https://doi.org/10.3389/fmicb.2023.1233705

Paper Intelligent Sensors for Sustainable Food and Drink Manufacturing

Watson, Nicholas J.; Bowler, Alexander L.; Rady, Ahmed et al. · 2021 · Frontiers in Sustainable Food Systems · DOI

Full title: Intelligent Sensors for Sustainable Food and Drink Manufacturing

Authors: Watson, Nicholas J.; Bowler, Alexander L.; Rady, Ahmed; Fisher, Oliver J.; Simeone, Alessandro; Escrig, Josep; Woolley, Elliot; Adedeji, Akinbode A.

Year: 2021

Venue: Frontiers in Sustainable Food Systems

DOI: https://doi.org/10.3389/fsufs.2021.642786

Paper rAAV Manufacturing: The Challenges of Soft Sensing during Upstream Processing

Iglesias, Cristovão Freitas; Ristovski, Miliça; Bolić, Miodrag et al. · 2023 · Bioengineering · DOI

Full title: rAAV Manufacturing: The Challenges of Soft Sensing during Upstream Processing

Authors: Iglesias, Cristovão Freitas; Ristovski, Miliça; Bolić, Miodrag; Čuperlović‐Culf, Miroslava

Year: 2023

Venue: Bioengineering

DOI: https://doi.org/10.3390/bioengineering10020229

Paper Influence of Incident Wavelength and Detector Material Selection on Fluorescence in the Application of Raman Spectroscopy to a Fungal Fermentation Process

Goldrick, Stephen; Lovett, David; Montague, G.A. et al. · 2018 · Bioengineering · DOI

Full title: Influence of Incident Wavelength and Detector Material Selection on Fluorescence in the Application of Raman Spectroscopy to a Fungal Fermentation Process

Authors: Goldrick, Stephen; Lovett, David; Montague, G.A.; Lennox, Barry

Year: 2018

Venue: Bioengineering

DOI: https://doi.org/10.3390/bioengineering5040079

Paper Comparison of Raman and Mid-Infrared Spectroscopy for Real-Time Monitoring of Yeast Fermentations: A Proof-of-Concept for Multi-Channel Photometric Sensors

Schalk, R.M.; Heintz, Annabell; Braun, Frank et al. · 2019 · Applied Sciences · DOI

Full title: Comparison of Raman and Mid-Infrared Spectroscopy for Real-Time Monitoring of Yeast Fermentations: A Proof-of-Concept for Multi-Channel Photometric Sensors

Authors: Schalk, R.M.; Heintz, Annabell; Braun, Frank; Iacono, Giuseppe; Rädle, Matthias; Gretz, Norbert; Methner, Frank‐Jürgen; Beuermann, Thomas

Year: 2019

Venue: Applied Sciences

DOI: https://doi.org/10.3390/app9122472

Paper Application of Raman Spectroscopy and Univariate Modelling As a Process Analytical Technology for Cell Therapy Bioprocessing.

Baradez, Marc-Olivier; Biziato, Daniela; Hassan, Enas et al. · 2018 · Frontiers in medicine · DOI

Full title: Application of Raman Spectroscopy and Univariate Modelling As a Process Analytical Technology for Cell Therapy Bioprocessing.

Authors: Baradez, Marc-Olivier; Biziato, Daniela; Hassan, Enas; Marshall, Damian

Year: 2018

Venue: Frontiers in medicine

DOI: https://doi.org/10.3389/fmed.2018.00047

Paper Multivariate Curve Resolution and Carbon Balance Constraint to Unravel FTIR Spectra from Fed-Batch Fermentation Samples

Vier, D.; Wambach, S.; Schünemann, Volker et al. · 2017 · Bioengineering · DOI

Full title: Multivariate Curve Resolution and Carbon Balance Constraint to Unravel FTIR Spectra from Fed-Batch Fermentation Samples

Authors: Vier, D.; Wambach, S.; Schünemann, Volker; Gollmer, Klaus-Uwe

Year: 2017

Venue: Bioengineering

DOI: https://doi.org/10.3390/bioengineering4010009

Paper Online 2D Fluorescence Monitoring in Microtiter Plates Allows Prediction of Cultivation Parameters and Considerable Reduction in Sampling Efforts for Parallel Cultivations of Hansenula polymorpha

Berg, Christoph; Ihling, Nina; Finger, Maurice et al. · 2022 · Bioengineering · DOI

Full title: Online 2D Fluorescence Monitoring in Microtiter Plates Allows Prediction of Cultivation Parameters and Considerable Reduction in Sampling Efforts for Parallel Cultivations of Hansenula polymorpha

Authors: Berg, Christoph; Ihling, Nina; Finger, Maurice; Paquet‐Durand, Olivier; Hitzmann, Bernd; Büchs, Jochen

Year: 2022

Venue: Bioengineering

DOI: https://doi.org/10.3390/bioengineering9090438

Paper In-Line Monitoring of Polyhydroxyalkanoate (PHA) Production during High-Cell-Density Plant Oil Cultivations Using Photon Density Wave Spectroscopy

Gutschmann, Björn; Schiewe, Thomas; Weiske, Manon T.H. et al. · 2019 · Bioengineering · DOI

Full title: In-Line Monitoring of Polyhydroxyalkanoate (PHA) Production during High-Cell-Density Plant Oil Cultivations Using Photon Density Wave Spectroscopy

Authors: Gutschmann, Björn; Schiewe, Thomas; Weiske, Manon T.H.; Neubauer, Peter; Hass, Roland; Riedel, Sebastian L.

Year: 2019

Venue: Bioengineering

DOI: https://doi.org/10.3390/bioengineering6030085

Paper Cultivating Multidisciplinarity: Manufacturing and Sensing Challenges in Cultured Meat Production

Djisalov, Mila; Knežić, Teodora; Podunavac, Ivana et al. · 2021 · Biology · DOI

Full title: Cultivating Multidisciplinarity: Manufacturing and Sensing Challenges in Cultured Meat Production

Authors: Djisalov, Mila; Knežić, Teodora; Podunavac, Ivana; Živojević, Kristina; Radonić, Vasa; Knežević, Nikola Ž.; Bobrinetskiy, Ivan; Gadjanski, Ivana

Year: 2021

Venue: Biology

DOI: https://doi.org/10.3390/biology10030204

Paper From Spatial-Temporal Multiscale Modeling to Application: Bridging the Valley of Death in Industrial Biotechnology

Wang, Xueting; Mohsin, Ali; Sun, Yifei et al. · 2023 · Bioengineering · DOI

Full title: From Spatial-Temporal Multiscale Modeling to Application: Bridging the Valley of Death in Industrial Biotechnology

Authors: Wang, Xueting; Mohsin, Ali; Sun, Yifei; Li, Chao; Zhuang, Yingping; Wang, Guan

Year: 2023

Venue: Bioengineering

DOI: https://doi.org/10.3390/bioengineering10060744

Paper Process Analytical Technology for Advanced Process Control in Biologics Manufacturing with the Aid of Macroscopic Kinetic Modeling.

Kornecki, Martin; Strube, Jochen · 2018 · Bioengineering (Basel, Switzerland) · DOI

Full title: Process Analytical Technology for Advanced Process Control in Biologics Manufacturing with the Aid of Macroscopic Kinetic Modeling.

Authors: Kornecki, Martin; Strube, Jochen

Year: 2018

Venue: Bioengineering (Basel, Switzerland)

DOI: https://doi.org/10.3390/bioengineering5010025

Paper Multi-Sensing Monitoring of the Microalgae Biomass Cultivation Systems for Biofuels and Added Value Products Synthesis—Challenges and Opportunities

Dębowski, Marcin; Kazimierowicz, Joanna; Zieliński, Marcin · 2025 · Applied Sciences · DOI

Full title: Multi-Sensing Monitoring of the Microalgae Biomass Cultivation Systems for Biofuels and Added Value Products Synthesis—Challenges and Opportunities

Authors: Dębowski, Marcin; Kazimierowicz, Joanna; Zieliński, Marcin

Year: 2025

Venue: Applied Sciences

DOI: https://doi.org/10.3390/app15137324

Paper Representative Sampling Implementation in Online VFA/TIC Monitoring for Anaerobic Digestion

Wilches, Camilo; Vaske, Maik; Hartmann, Kilian et al. · 2019 · Energies · DOI

Full title: Representative Sampling Implementation in Online VFA/TIC Monitoring for Anaerobic Digestion

Authors: Wilches, Camilo; Vaske, Maik; Hartmann, Kilian; Nelles, Michael

Year: 2019

Venue: Energies

DOI: https://doi.org/10.3390/en12061179

Paper The Use of UV-Vis Spectroscopy in Bioprocess and Fermentation Monitoring

Roberts, Jessica; Power, Aoife; Chapman, James et al. · 2018 · Fermentation · DOI

Full title: The Use of UV-Vis Spectroscopy in Bioprocess and Fermentation Monitoring

Authors: Roberts, Jessica; Power, Aoife; Chapman, James; Chandra, Shaneel; Cozzolino, Daniel

Year: 2018

Venue: Fermentation

DOI: https://doi.org/10.3390/fermentation4010018

Paper N-1 Perfusion Platform Development Using a Capacitance Probe for Biomanufacturing

Emily S. C. Rittershaus; M. Rehmann; Jianlin Xu et al. · 2022 · Bioengineering · DOI

Full title: N-1 Perfusion Platform Development Using a Capacitance Probe for Biomanufacturing

Authors: Emily S. C. Rittershaus; M. Rehmann; Jianlin Xu; Qin He; Charles Hill; Jeffrey C Swanberg; Michael C. Borys; Z. Li; Anurag Khetan

Year: 2022

Venue: Bioengineering

DOI: https://doi.org/10.3390/bioengineering9040128

Paper Sensors and Techniques for On-Line Determination of Cell Viability in Bioprocess Monitoring

Rösner, Laura; Walter, Franziska; Ude, Christian et al. · 2022 · Bioengineering · DOI

Full title: Sensors and Techniques for On-Line Determination of Cell Viability in Bioprocess Monitoring

Authors: Rösner, Laura; Walter, Franziska; Ude, Christian; John, Gernot T.; Beutel, Sascha

Year: 2022

Venue: Bioengineering

DOI: https://doi.org/10.3390/bioengineering9120762

Paper Factors Affecting Microalgae Production for Biofuels and the Potentials of Chemometric Methods in Assessing and Optimizing Productivity

Musa, Mutah; Ayoko, Godwin A.; Ward, Andrew et al. · 2019 · Cells · DOI

Full title: Factors Affecting Microalgae Production for Biofuels and the Potentials of Chemometric Methods in Assessing and Optimizing Productivity

Authors: Musa, Mutah; Ayoko, Godwin A.; Ward, Andrew; Rösch, Christine; Brown, Richard; Rainey, Thomas J.

Year: 2019

Venue: Cells

DOI: https://doi.org/10.3390/cells8080851

Paper Next-Generation Chemical Sensors: The Convergence of Nanomaterials, Advanced Characterization, and Real-World Applications

Machín, Abniel; Márquez, Francisco · 2025 · Chemosensors · DOI

Full title: Next-Generation Chemical Sensors: The Convergence of Nanomaterials, Advanced Characterization, and Real-World Applications

Authors: Machín, Abniel; Márquez, Francisco

Year: 2025

Venue: Chemosensors

DOI: https://doi.org/10.3390/chemosensors13090345

Paper Application of Spectroscopy Techniques for Monitoring (Bio)Catalytic Processes in Continuously Operated Microreactor Systems

Jurina, Tamara; Cvetnić, Tea Sokač; Šalić, Anita et al. · 2023 · Catalysts · DOI

Full title: Application of Spectroscopy Techniques for Monitoring (Bio)Catalytic Processes in Continuously Operated Microreactor Systems

Authors: Jurina, Tamara; Cvetnić, Tea Sokač; Šalić, Anita; Benković, Maja; Valinger, Davor; Kljusurić, Jasenka Gajdoš; Zelić, Bruno; Tušek, Ana Jurinjak

Year: 2023

Venue: Catalysts

DOI: https://doi.org/10.3390/catal13040690

Paper Discrimination of Stressed and Non-Stressed Food-Related Bacteria Using Raman-Microspectroscopy

Klein, Daniel; Breuch, René; Reinmüller, Jessica et al. · 2022 · Foods · DOI

Full title: Discrimination of Stressed and Non-Stressed Food-Related Bacteria Using Raman-Microspectroscopy

Authors: Klein, Daniel; Breuch, René; Reinmüller, Jessica; Engelhard, Carsten; Kaul, Peter

Year: 2022

Venue: Foods

DOI: https://doi.org/10.3390/foods11101506

Paper Informative Wavelength Selection for Evaluation of Bacterial Spoilage in Raw Salmon (Salmo salar) Fillet Using FT-NIR Spectroscopy

Panwar, R. D.; Lin, Shin‐Ping; Lin, Shyh‐Hsiang et al. · 2025 · Foods · DOI

Full title: Informative Wavelength Selection for Evaluation of Bacterial Spoilage in Raw Salmon (Salmo salar) Fillet Using FT-NIR Spectroscopy

Authors: Panwar, R. D.; Lin, Shin‐Ping; Lin, Shyh‐Hsiang; Lin, Jer‐An; Wang, Yu-Jen; Chuang, Yung‐Kun

Year: 2025

Venue: Foods

DOI: https://doi.org/10.3390/foods14122074

Paper Characterization and Viability Prediction of Commercial Probiotic Supplements under Temperature and Concentration Conditioning Factors by NIR Spectroscopy

Bósquez, Juan Pablo Aguinaga; Oğuz, Esma; Cebeci, Aybike et al. · 2022 · Fermentation · DOI

Full title: Characterization and Viability Prediction of Commercial Probiotic Supplements under Temperature and Concentration Conditioning Factors by NIR Spectroscopy

Authors: Bósquez, Juan Pablo Aguinaga; Oğuz, Esma; Cebeci, Aybike; Majadi, Mariem; Kiskó, Gabriella; Gillay, Zoltán; Kovács, Zoltán

Year: 2022

Venue: Fermentation

DOI: https://doi.org/10.3390/fermentation8020066

Paper A Review on the Application of Near-Infrared Technology for Monitoring and Control of Food Fermentation Process

Zhang, Ao; Liu, Y; Yu, Chao et al. · 2025 · Fermentation · DOI

Full title: A Review on the Application of Near-Infrared Technology for Monitoring and Control of Food Fermentation Process

Authors: Zhang, Ao; Liu, Y; Yu, Chao; Yu, Mengting; Xu, Yang; Gao, Bingning; Yang, Chenyu; Xia, Jianye; Zheng, Yu; Song, Jia; Wang, M. R.

Year: 2025

Venue: Fermentation

DOI: https://doi.org/10.3390/fermentation12010004

Paper Predicting Alcohol Concentration during Beer Fermentation Using Ultrasonic Measurements and Machine Learning

Bowler, Alexander L.; Escrig, Josep; Pound, Michael P. et al. · 2021 · Fermentation · DOI

Full title: Predicting Alcohol Concentration during Beer Fermentation Using Ultrasonic Measurements and Machine Learning

Authors: Bowler, Alexander L.; Escrig, Josep; Pound, Michael P.; Watson, Nicholas J.

Year: 2021

Venue: Fermentation

DOI: https://doi.org/10.3390/fermentation7010034

Paper Characterizing Spray-Dried Powders through NIR Spectroscopy: Effect of Two Preparation Strategies for Calibration Samples and Comparison of Two Types of NIR Spectrometers

Tu, Zhiyang; Irudayaraj, Joseph; Lee, Youngsoo · 2023 · Foods · DOI

Full title: Characterizing Spray-Dried Powders through NIR Spectroscopy: Effect of Two Preparation Strategies for Calibration Samples and Comparison of Two Types of NIR Spectrometers

Authors: Tu, Zhiyang; Irudayaraj, Joseph; Lee, Youngsoo

Year: 2023

Venue: Foods

DOI: https://doi.org/10.3390/foods12030467

Paper Process Control via Electrical Impedance Tomography for Energy-Aware Industrial Systems

Król, Krzysztof; Kłosowski, Grzegorz; Rymarczyk, Tomasz et al. · 2025 · Energies · DOI

Full title: Process Control via Electrical Impedance Tomography for Energy-Aware Industrial Systems

Authors: Król, Krzysztof; Kłosowski, Grzegorz; Rymarczyk, Tomasz; Gauda, Konrad; Kulisz, Monika; Golec, Ewa; Surowiec, Agnieszka

Year: 2025

Venue: Energies

DOI: https://doi.org/10.3390/en18225956

Paper A Review of Sensors for the Monitoring, Modeling, and Control of Commercial Wine Fermentations

Boulton, Roger B.; Nelson, James T.; Knoesen, A. · 2025 · Fermentation · DOI

Full title: A Review of Sensors for the Monitoring, Modeling, and Control of Commercial Wine Fermentations

Authors: Boulton, Roger B.; Nelson, James T.; Knoesen, A.

Year: 2025

Venue: Fermentation

DOI: https://doi.org/10.3390/fermentation11060329

Paper Smart Fermentation Technologies: Microbial Process Control in Traditional Fermented Foods

Yee, Chong Shin; Zahia-Azizan, Nur Asyiqin; Rahim, Muhamad Hafiz Abd et al. · 2025 · Fermentation · DOI

Full title: Smart Fermentation Technologies: Microbial Process Control in Traditional Fermented Foods

Authors: Yee, Chong Shin; Zahia-Azizan, Nur Asyiqin; Rahim, Muhamad Hafiz Abd; Zaini, Nurul Aqilah Mohd; Raja-Razali, Raja Balqis; Ushidee-Radzi, Muhammad Ameer; Ilham, Zul; Wan‐Mohtar, Wan Abd Al Qadr Imad

Year: 2025

Venue: Fermentation

DOI: https://doi.org/10.3390/fermentation11060323

Paper SVR Chemometrics to Quantify β-Lactoglobulin and α-Lactalbumin in Milk Using MIR

Babatunde, Habeeb Abolaji; Collins, Joseph M.; Lukman, Rianat Olabisi et al. · 2024 · Foods · DOI

Full title: SVR Chemometrics to Quantify β-Lactoglobulin and α-Lactalbumin in Milk Using MIR

Authors: Babatunde, Habeeb Abolaji; Collins, Joseph M.; Lukman, Rianat Olabisi; Saxton, Rose; Andersen, Tim; McDougal, Owen M.

Year: 2024

Venue: Foods

DOI: https://doi.org/10.3390/foods13010166

Paper Comparative Analysis of XGB, CNN, and ResNet Models for Predicting Moisture Content in Porphyra yezoensis Using Near-Infrared Spectroscopy

Zhang, Wenwen; Pan, Mingxuan; Wang, Peng et al. · 2024 · Foods · DOI

Full title: Comparative Analysis of XGB, CNN, and ResNet Models for Predicting Moisture Content in Porphyra yezoensis Using Near-Infrared Spectroscopy

Authors: Zhang, Wenwen; Pan, Mingxuan; Wang, Peng; Jiao, Xue; Zhou, Xinghu; Sun, Wenke; Hu, Yadong; Shen, Zhaopeng

Year: 2024

Venue: Foods

DOI: https://doi.org/10.3390/foods13193023

Paper Applications of Infrared and Raman Spectroscopies to Probiotic Investigation

Santos, Mauricio; Gerbino, Esteban; Tymczyszyn, E. Elizabeth et al. · 2015 · Foods · DOI

Full title: Applications of Infrared and Raman Spectroscopies to Probiotic Investigation

Authors: Santos, Mauricio; Gerbino, Esteban; Tymczyszyn, E. Elizabeth; Gómez‐Zavaglia, Andrea

Year: 2015

Venue: Foods

DOI: https://doi.org/10.3390/foods4030283

Paper Assessment of Biotechnologically Important Filamentous Fungal Biomass by Fourier Transform Raman Spectroscopy

Dzurendová, Simona; Shapaval, Volha; Tafintseva, Valeria et al. · 2021 · International Journal of Molecular Sciences · DOI

Full title: Assessment of Biotechnologically Important Filamentous Fungal Biomass by Fourier Transform Raman Spectroscopy

Authors: Dzurendová, Simona; Shapaval, Volha; Tafintseva, Valeria; Köhler, Achim; Byrtusová, Dana; Szotkowski, Martin; Márová, Ivana; Zimmermann, Boris

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms22136710

Paper Metabolic Fingerprinting of Pseudomonas putida DOT-T1E Strains: Understanding the Influence of Divalent Cations in Adaptation Mechanisms Following Exposure to Toluene

Sayqal, Ali; Xu, Yun; Trivedi, Drupad K. et al. · 2016 · Metabolites · DOI

Full title: Metabolic Fingerprinting of Pseudomonas putida DOT-T1E Strains: Understanding the Influence of Divalent Cations in Adaptation Mechanisms Following Exposure to Toluene

Authors: Sayqal, Ali; Xu, Yun; Trivedi, Drupad K.; AlMasoud, Najla; Ellis, David I.; Goodacre, Royston

Year: 2016

Venue: Metabolites

DOI: https://doi.org/10.3390/metabo6020014

Paper Illuminating the Tiny World: A Navigation Guide for Proper Raman Studies on Microorganisms

Frempong, Sandra Baaba; Salbreiter, Markus; Mostafapour, Sara et al. · 2024 · Molecules · DOI

Full title: Illuminating the Tiny World: A Navigation Guide for Proper Raman Studies on Microorganisms

Authors: Frempong, Sandra Baaba; Salbreiter, Markus; Mostafapour, Sara; Pistiki, Aikaterini; Bocklitz, Thomas; Rösch, Petra; Popp, Jürgen

Year: 2024

Venue: Molecules

DOI: https://doi.org/10.3390/molecules29051077

Paper Aspects and Implementation of Pharmaceutical Quality by Design from Conceptual Frameworks to Industrial Applications.

Yang, Shiwei; Hu, Xingming; Zhu, Jinmiao et al. · 2025 · Pharmaceutics · DOI

Full title: Aspects and Implementation of Pharmaceutical Quality by Design from Conceptual Frameworks to Industrial Applications.

Authors: Yang, Shiwei; Hu, Xingming; Zhu, Jinmiao; Zheng, Bin; Bi, Wenjie; Wang, Xiaohong; Wu, Jialing; Mi, Zimeng; Wu, Yifei

Year: 2025

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics17050623

Paper Analysis of the Composition of Different Instars of Tenebrio molitor Larvae using Near-Infrared Reflectance Spectroscopy for Prediction of Amino and Fatty Acid Content

Kröncke, Nina; Wittke, Stefan; Steinmann, Nico et al. · 2023 · Insects · DOI

Full title: Analysis of the Composition of Different Instars of Tenebrio molitor Larvae using Near-Infrared Reflectance Spectroscopy for Prediction of Amino and Fatty Acid Content

Authors: Kröncke, Nina; Wittke, Stefan; Steinmann, Nico; Benning, R.

Year: 2023

Venue: Insects

DOI: https://doi.org/10.3390/insects14040310

Paper Genotypic and Phenotypic Characterisation of Staphylococcus aureus Enterotoxins Using Single-Cell Raman Spectroscopy and Metabolomics

Song, X H; Zhang, Z Z; Zhan, Taijie et al. · 2026 · Pathogens · DOI

Full title: Genotypic and Phenotypic Characterisation of Staphylococcus aureus Enterotoxins Using Single-Cell Raman Spectroscopy and Metabolomics

Authors: Song, X H; Zhang, Z Z; Zhan, Taijie; Liu, Li; Wei, Xiaoyue; Liu, Ying; Tao, Jing; Xie, Mengjiao; Liu, Gege; Wang, Duochun; Fu, Yu; Yan, Xiaoli; Wei, Qi

Year: 2026

Venue: Pathogens

DOI: https://doi.org/10.3390/pathogens15030255

Paper Continuous Manufacturing of Recombinant Drugs: Comprehensive Analysis of Cost Reduction Strategies, Regulatory Pathways, and Global Implementation

Niazi, Sarfaraz K. · 2025 · Pharmaceuticals · DOI

Full title: Continuous Manufacturing of Recombinant Drugs: Comprehensive Analysis of Cost Reduction Strategies, Regulatory Pathways, and Global Implementation

Authors: Niazi, Sarfaraz K.

Year: 2025

Venue: Pharmaceuticals

DOI: https://doi.org/10.3390/ph18081157

Paper Modern Sensor Tools and Techniques for Monitoring, Controlling, and Improving Cell Culture Processes

Reyes, Sebastian Juan; Durocher, Yves; Pham, Phuong Lan et al. · 2022 · Processes · DOI

Full title: Modern Sensor Tools and Techniques for Monitoring, Controlling, and Improving Cell Culture Processes

Authors: Reyes, Sebastian Juan; Durocher, Yves; Pham, Phuong Lan; Henry, Olivier

Year: 2022

Venue: Processes

DOI: https://doi.org/10.3390/pr10020189

Paper Merging Real-Time NIR and Process Parameter Measurements in a Fluidized Bed Granulation Process to Predict Particle Size.

Jovic, Ozren; O'Mahony, Marcus; Solomon, Samuel et al. · 2025 · Pharmaceutics · DOI

Full title: Merging Real-Time NIR and Process Parameter Measurements in a Fluidized Bed Granulation Process to Predict Particle Size.

Authors: Jovic, Ozren; O'Mahony, Marcus; Solomon, Samuel; Egan, David; O'Callaghan, Chris; McCormack, Caroline; Jones, Ian; Cronin, Patrick; Walker, Gavin M; Mouras, Rabah

Year: 2025

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics17060720

Paper Working within the Design Space: Do Our Static Process Characterization Methods Suffice?

von Stosch, Moritz; Schenkendorf, René; Geldhof, Geoffroy et al. · 2020 · Pharmaceutics · DOI

Full title: Working within the Design Space: Do Our Static Process Characterization Methods Suffice?

Authors: von Stosch, Moritz; Schenkendorf, René; Geldhof, Geoffroy; Varsakelis, Christos; Mariti, Marco; Dessoy, Sandrine; Vandercammen, Annick; Pysik, Alexander; Sanders, Matthew

Year: 2020

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics12060562

Paper Controlled Release of D-Limonene from Biodegradable Films with Enzymatic Treatment

Nakonechnyi, V. I.; Havryliak, V. V.; Lubеnets, Vira · 2025 · Polymers · DOI

Full title: Controlled Release of D-Limonene from Biodegradable Films with Enzymatic Treatment

Authors: Nakonechnyi, V. I.; Havryliak, V. V.; Lubеnets, Vira

Year: 2025

Venue: Polymers

DOI: https://doi.org/10.3390/polym17162238

Paper Automatic Control of Nucleation and Crystal Growth Using Online Raman Analyzer

Li, Aofei; Chang, Boxue; Li, Zhen et al. · 2024 · Processes · DOI

Full title: Automatic Control of Nucleation and Crystal Growth Using Online Raman Analyzer

Authors: Li, Aofei; Chang, Boxue; Li, Zhen; Chen, Biao; Ji, Kaidi; Chen, Yangshun; Ou, S. L.; Zhang, Fengming; Wei, Jiaoning; Ruan, Yinlan

Year: 2024

Venue: Processes

DOI: https://doi.org/10.3390/pr12040774

Paper Process Analytical Technology Tools for Monitoring Pharmaceutical Unit Operations: A Control Strategy for Continuous Process Verification.

Kim, Eun Ji; Kim, Ji Hyeon; Kim, Min-Soo et al. · 2021 · Pharmaceutics · DOI

Full title: Process Analytical Technology Tools for Monitoring Pharmaceutical Unit Operations: A Control Strategy for Continuous Process Verification.

Authors: Kim, Eun Ji; Kim, Ji Hyeon; Kim, Min-Soo; Jeong, Seong Hoon; Choi, Du Hyung

Year: 2021

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics13060919

Paper Raman Spectroscopy Coupled with Multivariate Statistical Process Control for Detecting Anomalies During Milk Coagulation

Sibono, Leonardo; Tronci, Stefania; Hedegaard, Martin A.B. et al. · 2025 · Processes · DOI

Full title: Raman Spectroscopy Coupled with Multivariate Statistical Process Control for Detecting Anomalies During Milk Coagulation

Authors: Sibono, Leonardo; Tronci, Stefania; Hedegaard, Martin A.B.; Errico, Massimiliano; Grosso, Massimiliano

Year: 2025

Venue: Processes

DOI: https://doi.org/10.3390/pr13113519

Paper NIR-Based Real-Time Monitoring of Freeze-Drying Processes: Application to Fault and Endpoint Detection

Massei, Ambra; Falco, Nunzia; Fissore, Davide · 2025 · Processes · DOI

Full title: NIR-Based Real-Time Monitoring of Freeze-Drying Processes: Application to Fault and Endpoint Detection

Authors: Massei, Ambra; Falco, Nunzia; Fissore, Davide

Year: 2025

Venue: Processes

DOI: https://doi.org/10.3390/pr13020452

Paper Monitoring of Nutrients, Metabolites, IgG Titer, and Cell Densities in 10 L Bioreactors Using Raman Spectroscopy and PLS Regression Models.

Rubini, Morandise; Boyer, Julien; Poulain, Jordane et al. · 2025 · Pharmaceutics · DOI

Full title: Monitoring of Nutrients, Metabolites, IgG Titer, and Cell Densities in 10 L Bioreactors Using Raman Spectroscopy and PLS Regression Models.

Authors: Rubini, Morandise; Boyer, Julien; Poulain, Jordane; Berger, Anaïs; Saillard, Thomas; Louet, Julien; Soucé, Martin; Roussel, Sylvie; Arnould, Sylvain; Vergès, Murielle; Chauchard-Rios, Fabien; Chourpa, Igor

Year: 2025

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics17040473

Paper Digital Twin Implementation for Manufacturing of Adjuvants

P. Phalak; Emanuele Tomba; Philippe Jehoulet et al. · 2023 · Processes · DOI

Full title: Digital Twin Implementation for Manufacturing of Adjuvants

Authors: P. Phalak; Emanuele Tomba; Philippe Jehoulet; André Kapitan-Gnimdu; Pablo Martin Soladana; Loredana Vagaggini; M. Brochier; B. Stevens; Thomas Peel; L. Strodiot; S. Dessoy

Year: 2023

Venue: Processes

DOI: https://doi.org/10.3390/pr11061717

Paper Accelerating Biomanufacturing by Modeling of Continuous Bioprocessing—Piloting Case Study of Monoclonal Antibody Manufacturing

Kornecki, Martin; Schmidt, A.; Lohmann, Lara Julia et al. · 2019 · Processes · DOI

Full title: Accelerating Biomanufacturing by Modeling of Continuous Bioprocessing—Piloting Case Study of Monoclonal Antibody Manufacturing

Authors: Kornecki, Martin; Schmidt, A.; Lohmann, Lara Julia; Huter, Maximilian Johannes; Mestmäcker, Fabian; Klepzig, L.; Mouellef, Mourad; Zobel‐Roos, Steffen; Strube, Jochen

Year: 2019

Venue: Processes

DOI: https://doi.org/10.3390/pr7080495

Paper Raman Microspectroscopy of Individual Algal Cells: Sensing Unsaturation of Storage Lipids in vivo

Samek, Ota; Jonáš, Alexandr; Pilát, Zdeněk et al. · 2010 · Sensors · DOI

Full title: Raman Microspectroscopy of Individual Algal Cells: Sensing Unsaturation of Storage Lipids in vivo

Authors: Samek, Ota; Jonáš, Alexandr; Pilát, Zdeněk; Zemánek, Pavel; Nedbal, Ladislav; Třı́ska, Jan; Kotas, Petr; Trtílek, Martin

Year: 2010

Venue: Sensors

DOI: https://doi.org/10.3390/s100908635

Paper A Chemometric Tool to Monitor and Predict Cell Viability in Filamentous Fungi Bioprocesses Using UV Chromatogram Fingerprints

Doppler, Philipp; Veiter, Lukas; Spadiut, Oliver et al. · 2020 · Processes · DOI

Full title: A Chemometric Tool to Monitor and Predict Cell Viability in Filamentous Fungi Bioprocesses Using UV Chromatogram Fingerprints

Authors: Doppler, Philipp; Veiter, Lukas; Spadiut, Oliver; Herwig, Christoph; Rajamanickam, Vignesh

Year: 2020

Venue: Processes

DOI: https://doi.org/10.3390/pr8040461

Paper A Review of Intelligent Modeling for Microalgae Systems: Integrating Data Mining, Machine Learning, and Hybrid Approaches

Freitas, Geovani R.; Badenes, Sara M.; Oliveira, Rui et al. · 2025 · Processes · DOI

Full title: A Review of Intelligent Modeling for Microalgae Systems: Integrating Data Mining, Machine Learning, and Hybrid Approaches

Authors: Freitas, Geovani R.; Badenes, Sara M.; Oliveira, Rui; Martins, F.G.

Year: 2025

Venue: Processes

DOI: https://doi.org/10.3390/pr13092956

Paper Dielectric Spectroscopy to Improve the Production of rAAV Used in Gene Therapy

Pais, Daniel A. M.; Brown, Chris W.; Neuman, Anastasia et al. · 2020 · Processes · DOI

Full title: Dielectric Spectroscopy to Improve the Production of rAAV Used in Gene Therapy

Authors: Pais, Daniel A. M.; Brown, Chris W.; Neuman, Anastasia; Mathur, Krishanu; Isidro, Inês A.; Alves, Paula M.; Slade, Peter G.

Year: 2020

Venue: Processes

DOI: https://doi.org/10.3390/pr8111456

Paper Why Is Batch Processing Still Dominating the Biologics Landscape? Towards an Integrated Continuous Bioprocessing Alternative

Kumar, Ashish; Udugama, Isuru A.; Gargalo, Carina L. et al. · 2020 · Processes · DOI

Full title: Why Is Batch Processing Still Dominating the Biologics Landscape? Towards an Integrated Continuous Bioprocessing Alternative

Authors: Kumar, Ashish; Udugama, Isuru A.; Gargalo, Carina L.; Gernaey, Krist V.

Year: 2020

Venue: Processes

DOI: https://doi.org/10.3390/pr8121641

Paper Model-Based Process Optimization for the Production of Macrolactin D by Paenibacillus polymyxa

Krämer, Dominik; Wilms, Terrance; King, Rudibert · 2020 · Processes · DOI

Full title: Model-Based Process Optimization for the Production of Macrolactin D by Paenibacillus polymyxa

Authors: Krämer, Dominik; Wilms, Terrance; King, Rudibert

Year: 2020

Venue: Processes

DOI: https://doi.org/10.3390/pr8070752

Paper Process Analytical Technology for Precipitation Process Integration into Biologics Manufacturing towards Autonomous Operation—mAb Case Study

Lohmann, Lara Julia; Strube, Jochen · 2021 · Processes · DOI

Full title: Process Analytical Technology for Precipitation Process Integration into Biologics Manufacturing towards Autonomous Operation—mAb Case Study

Authors: Lohmann, Lara Julia; Strube, Jochen

Year: 2021

Venue: Processes

DOI: https://doi.org/10.3390/pr9030488

Paper Fluorescence Spectroscopy and Chemometric Modeling for Bioprocess Monitoring

Faassen, Saskia; Hitzmann, Bernd · 2015 · Sensors · DOI

Full title: Fluorescence Spectroscopy and Chemometric Modeling for Bioprocess Monitoring

Authors: Faassen, Saskia; Hitzmann, Bernd

Year: 2015

Venue: Sensors

DOI: https://doi.org/10.3390/s150510271

Paper On the Use of Surface Plasmon Resonance-Based Biosensors for Advanced Bioprocess Monitoring

Gaudreault, Jimmy; Forest‐Nault, Catherine; Crescenzo, Grégory De et al. · 2021 · Processes · DOI

Full title: On the Use of Surface Plasmon Resonance-Based Biosensors for Advanced Bioprocess Monitoring

Authors: Gaudreault, Jimmy; Forest‐Nault, Catherine; Crescenzo, Grégory De; Durocher, Yves; Henry, Olivier

Year: 2021

Venue: Processes

DOI: https://doi.org/10.3390/pr9111996

Paper Recent Progress in Lab-On-a-Chip Systems for the Monitoring of Metabolites for Mammalian and Microbial Cell Research

Dervisevic, Esma; Tuck, Kellie L.; Voelcker, Nicolas H. et al. · 2019 · Sensors · DOI

Full title: Recent Progress in Lab-On-a-Chip Systems for the Monitoring of Metabolites for Mammalian and Microbial Cell Research

Authors: Dervisevic, Esma; Tuck, Kellie L.; Voelcker, Nicolas H.; Cadarso, Víctor J.

Year: 2019

Venue: Sensors

DOI: https://doi.org/10.3390/s19225027

Paper Wavelength Selection FOR Rapid Identification of Different Particle Size Fractions of Milk Powder Using Hyperspectral Imaging

Khan, Asma; Munir, Muhammad Tajammal; Yu, Wei et al. · 2020 · Sensors · DOI

Full title: Wavelength Selection FOR Rapid Identification of Different Particle Size Fractions of Milk Powder Using Hyperspectral Imaging

Authors: Khan, Asma; Munir, Muhammad Tajammal; Yu, Wei; Young, Brent R.

Year: 2020

Venue: Sensors

DOI: https://doi.org/10.3390/s20164645

Paper Monitoring E. coli Cell Integrity by ATR-FTIR Spectroscopy and Chemometrics: Opportunities and Caveats

Kastenhofer, Jens; Libiseller-Egger, Julian; Rajamanickam, Vignesh et al. · 2021 · Processes · DOI

Full title: Monitoring E. coli Cell Integrity by ATR-FTIR Spectroscopy and Chemometrics: Opportunities and Caveats

Authors: Kastenhofer, Jens; Libiseller-Egger, Julian; Rajamanickam, Vignesh; Spadiut, Oliver

Year: 2021

Venue: Processes

DOI: https://doi.org/10.3390/pr9030422

Paper Towards Autonomous Operation by Advanced Process Control—Process Analytical Technology for Continuous Biologics Antibody Manufacturing

Helgers, Heribert; Schmidt, A.; Lohmann, Lara Julia et al. · 2021 · Processes · DOI

Full title: Towards Autonomous Operation by Advanced Process Control—Process Analytical Technology for Continuous Biologics Antibody Manufacturing

Authors: Helgers, Heribert; Schmidt, A.; Lohmann, Lara Julia; Vetter, Florian Lukas; Juckers, Alex; Jensch, Christoph; Mouellef, Mourad; Zobel‐Roos, Steffen; Strube, Jochen

Year: 2021

Venue: Processes

DOI: https://doi.org/10.3390/pr9010172

Paper Improving Sensitivity in Raman Imaging for Thin Layered and Powdered Food Analysis Utilizing a Reflection Mirror

Lohumi, Santosh; Kim, Moon S.; Qin, Jianwei et al. · 2019 · Sensors · DOI

Full title: Improving Sensitivity in Raman Imaging for Thin Layered and Powdered Food Analysis Utilizing a Reflection Mirror

Authors: Lohumi, Santosh; Kim, Moon S.; Qin, Jianwei; Cho, Byoung–Kwan

Year: 2019

Venue: Sensors

DOI: https://doi.org/10.3390/s19122698

Paper NIR Instruments and Prediction Methods for Rapid Access to Grain Protein Content in Multiple Cereals

Chadalavada, Keerthi; Anbazhagan, Krithika; Ndour, Adama et al. · 2022 · Sensors · DOI

Full title: NIR Instruments and Prediction Methods for Rapid Access to Grain Protein Content in Multiple Cereals

Authors: Chadalavada, Keerthi; Anbazhagan, Krithika; Ndour, Adama; Choudhary, Sunita; Palmer, William E.; Flynn, Jamie R.; Mallayee, Srikanth; Pothu, Sharada; Prasad, Kodukula V. S. V.; Varijakshapanikar, Padmakumar; Jones, Chris S.; Kholová, Jana

Year: 2022

Venue: Sensors

DOI: https://doi.org/10.3390/s22103710

Paper Absorption Spectra Description for T-Cell Concentrations Determination and Simultaneous Measurements of Species during Co-Cultures

Wacogne, B.; Vaccari, Naïs; Koubevi, Claudia et al. · 2022 · Sensors · DOI

Full title: Absorption Spectra Description for T-Cell Concentrations Determination and Simultaneous Measurements of Species during Co-Cultures

Authors: Wacogne, B.; Vaccari, Naïs; Koubevi, Claudia; Belinger-Podevin, Marine; Robert-Nicoud, Marjorie; Rouleau, Alain; Frelet‐Barrand, Annie

Year: 2022

Venue: Sensors

DOI: https://doi.org/10.3390/s22239223

Paper Monitoring Mixing Processes Using Ultrasonic Sensors and Machine Learning

Bowler, Alexander L.; Bakalis, Serafim; Watson, Nicholas J. · 2020 · Sensors · DOI

Full title: Monitoring Mixing Processes Using Ultrasonic Sensors and Machine Learning

Authors: Bowler, Alexander L.; Bakalis, Serafim; Watson, Nicholas J.

Year: 2020

Venue: Sensors

DOI: https://doi.org/10.3390/s20071813

Paper Rapid Determination of Chlorogenic Acid, Luteoloside and 3,5-O-dicaffeoylquinic Acid in Chrysanthemum Using Near-Infrared Spectroscopy

Xia, Zhengyan; Sun, Yiming; Cai, Chengyong et al. · 2019 · Sensors · DOI

Full title: Rapid Determination of Chlorogenic Acid, Luteoloside and 3,5-O-dicaffeoylquinic Acid in Chrysanthemum Using Near-Infrared Spectroscopy

Authors: Xia, Zhengyan; Sun, Yiming; Cai, Chengyong; He, Yong; Nie, Pengcheng

Year: 2019

Venue: Sensors

DOI: https://doi.org/10.3390/s19091981

Paper Fiber-Optic Chemical Sensors and Fiber-Optic Bio-Sensors

Pospı́šilová, Marie; Kuncová, Gabriela; Trögl, Josef · 2015 · Sensors · DOI

Full title: Fiber-Optic Chemical Sensors and Fiber-Optic Bio-Sensors

Authors: Pospı́šilová, Marie; Kuncová, Gabriela; Trögl, Josef

Year: 2015

Venue: Sensors

DOI: https://doi.org/10.3390/s151025208

Paper Raman Spectroscopy of Glass Beads in Ammonium Nitrate Solution and Compensation of Signal Losses

Spoor, Erik; Rädle, Matthias; Repke, Jens‐Uwe · 2024 · Sensors · DOI

Full title: Raman Spectroscopy of Glass Beads in Ammonium Nitrate Solution and Compensation of Signal Losses

Authors: Spoor, Erik; Rädle, Matthias; Repke, Jens‐Uwe

Year: 2024

Venue: Sensors

DOI: https://doi.org/10.3390/s24020314

Paper Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors.

Graf, Alexander; Woodhams, Angus; Nelson, Michael et al. · 2022 · Sensors (Basel, Switzerland) · DOI

Full title: Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors.

Authors: Graf, Alexander; Woodhams, Angus; Nelson, Michael; Richardson, Douglas D; Short, Steven M; Brower, Mark; Hoehse, Marek

Year: 2022

Venue: Sensors (Basel, Switzerland)

DOI: https://doi.org/10.3390/s22093397

Paper Halfway to Automated Feeding of Chinese Hamster Ovary Cells.

Tomažič, Simon; Škrjanc, Igor · 2023 · Sensors (Basel, Switzerland) · DOI

Full title: Halfway to Automated Feeding of Chinese Hamster Ovary Cells.

Authors: Tomažič, Simon; Škrjanc, Igor

Year: 2023

Venue: Sensors (Basel, Switzerland)

DOI: https://doi.org/10.3390/s23146618

Paper Smart Sensor Control and Monitoring of an Automated Cell Expansion Process

Nettleton, David; Marí‐Buyé, Núria; Martí-Soler, Helena et al. · 2023 · Sensors · DOI

Full title: Smart Sensor Control and Monitoring of an Automated Cell Expansion Process

Authors: Nettleton, David; Marí‐Buyé, Núria; Martí-Soler, Helena; Egan, Joseph R.; Hort, Simon; Horna, David; Costa, Miquel; Benítez‐Cano, Elia Vallejo; Goldrick, Stephen; Rafiq, Qasim A.; König, Niels; Schmitt, Robert; Reyes, Aldo R.

Year: 2023

Venue: Sensors

DOI: https://doi.org/10.3390/s23249676

Paper Raman Spectroscopy of Disperse Systems with Varying Particle Sizes and Correction of Signal Losses

Spoor, Erik; Oerke, Viktoria; Rädle, Matthias et al. · 2024 · Sensors · DOI

Full title: Raman Spectroscopy of Disperse Systems with Varying Particle Sizes and Correction of Signal Losses

Authors: Spoor, Erik; Oerke, Viktoria; Rädle, Matthias; Repke, Jens‐Uwe

Year: 2024

Venue: Sensors

DOI: https://doi.org/10.3390/s24103132

Paper Optical Fiber pH and Dissolved Oxygen Sensors for Bioreactor Monitoring: A Review

Cui, Guoqiang; Wu, Ruiquan; Cao, Lidan et al. · 2025 · Sensors · DOI

Full title: Optical Fiber pH and Dissolved Oxygen Sensors for Bioreactor Monitoring: A Review

Authors: Cui, Guoqiang; Wu, Ruiquan; Cao, Lidan; Abedin, Sabrina; Goel, Kanika; Yoon, Seongkyu; Wang, Xingwei

Year: 2025

Venue: Sensors

DOI: https://doi.org/10.3390/s26010010

Paper Aerogel-Lined Capillaries as Liquid-Core Waveguides for Raman Signal Gain of Aqueous Samples: Advanced Manufacturing and Performance Characterization

Spiske, Felix; Jakob, Lara Sophie; Lippold, M. et al. · 2024 · Sensors · DOI

Full title: Aerogel-Lined Capillaries as Liquid-Core Waveguides for Raman Signal Gain of Aqueous Samples: Advanced Manufacturing and Performance Characterization

Authors: Spiske, Felix; Jakob, Lara Sophie; Lippold, M.; Rahimi, Parvaneh; Joseph, Yvonne; Braeuer, Andreas

Year: 2024

Venue: Sensors

DOI: https://doi.org/10.3390/s24185979

Paper Batch Process Optimization Using Multi-Variate Data Analysis (MVDA)

-, Ravi Kiran Koppichetti · 2025 · International Journal For Multidisciplinary Research · DOI

Full title: Batch Process Optimization Using Multi-Variate Data Analysis (MVDA)

Authors: -, Ravi Kiran Koppichetti

Year: 2025

Venue: International Journal For Multidisciplinary Research

DOI: https://doi.org/10.36948/ijfmr.2025.v07i01.37180

Paper Challenges and Opportunities in the Process Development of Chimeric Vaccines

Chauhan, Shivani; Khasa, Yogender Pal · 2023 · Vaccines · DOI

Full title: Challenges and Opportunities in the Process Development of Chimeric Vaccines

Authors: Chauhan, Shivani; Khasa, Yogender Pal

Year: 2023

Venue: Vaccines

DOI: https://doi.org/10.3390/vaccines11121828

Paper Rapid In-Process Measurement of Live Virus Vaccine Potency Using Laser Force Cytology: Paving the Way for Rapid Vaccine Development.

McCracken, Reilly; Al-Nazal, Noor; Whitmer, Travis et al. · 2022 · Vaccines · DOI

Full title: Rapid In-Process Measurement of Live Virus Vaccine Potency Using Laser Force Cytology: Paving the Way for Rapid Vaccine Development.

Authors: McCracken, Reilly; Al-Nazal, Noor; Whitmer, Travis; Yi, Sijia; Wagner, James M; Hebert, Colin G; Lowry, Matthew J; Hayes, Peter R; Schneider, James W; Przybycien, Todd M; Mukherjee, Malini

Year: 2022

Venue: Vaccines

DOI: https://doi.org/10.3390/vaccines10101589

Paper Development and Application of an Automated Raman Sensor for Bioprocess Monitoring: From the Laboratory to an Algae Production Platform

Wieser, Wiviane; Assaf, Antony Ali; Gouic, Benjamin Le et al. · 2023 · Sensors · DOI

Full title: Development and Application of an Automated Raman Sensor for Bioprocess Monitoring: From the Laboratory to an Algae Production Platform

Authors: Wieser, Wiviane; Assaf, Antony Ali; Gouic, Benjamin Le; Dechandol, Emmanuel; Herve, Laura; Louineau, Thomas; Dib, Omar Hussein; Gonçalves, Olivier; Titica, Mariana; Couzinet‐Mossion, Aurélie; Wielgosz‐Collin, Gaëtane; Bittel, Marine; Thouand, Gérald

Year: 2023

Venue: Sensors

DOI: https://doi.org/10.3390/s23249746

Paper Comparison of different model-based observers for monitoring substrate and product concentrations in a Penicillium chrysogenum Fed-batch process

Berezhinskiy, Vladimir · 2019 · reposiTUm (TU Wien) · DOI

Full title: Comparison of different model-based observers for monitoring substrate and product concentrations in a Penicillium chrysogenum Fed-batch process

Authors: Berezhinskiy, Vladimir

Year: 2019

Venue: reposiTUm (TU Wien)

DOI: https://doi.org/10.34726/hss.2019.63131

Paper Moleküler Spektroskopinin Temel Prensipleri ve Uygulamaları

Bayraktutan, Tuğba; Akın, İlker; Demirel, Serkan et al. · 2026 · DOI

Full title: Moleküler Spektroskopinin Temel Prensipleri ve Uygulamaları

Authors: Bayraktutan, Tuğba; Akın, İlker; Demirel, Serkan; Koçyiğit, Adem; Selimoğlu, Faysal; Ayhan, Muhammed Emre; Ayhan, Muhammed Emre; Yiğit, Aybek

Year: 2026

DOI: https://doi.org/10.37609/akya.3978

Paper Differentiation of bacterial strains by means of surface enhanced FT-Raman spectroscopy

Kairyte, Kristina; Lukšiené, Živilė; Pučetaitė, Milda et al. · 2012 · Lithuanian Journal of Physics · DOI

Full title: Differentiation of bacterial strains by means of surface enhanced FT-Raman spectroscopy

Authors: Kairyte, Kristina; Lukšiené, Živilė; Pučetaitė, Milda; Šablinskas, Valdas

Year: 2012

Venue: Lithuanian Journal of Physics

DOI: https://doi.org/10.3952/physics.v52i3.2480

Paper Uncertainty Quantification Using Ensemble Learning and Monte Carlo Sampling for Performance Prediction and Monitoring in Cell Culture Processes

Khuat, Thanh Tung; Bassett, Robert; Otte, Ellen et al. · 2025 · Journal of Raman Spectroscopy · DOI

Full title: Uncertainty Quantification Using Ensemble Learning and Monte Carlo Sampling for Performance Prediction and Monitoring in Cell Culture Processes

Authors: Khuat, Thanh Tung; Bassett, Robert; Otte, Ellen; Gabryś, Bogdan

Year: 2025

Venue: Journal of Raman Spectroscopy

DOI: https://doi.org/10.1002/jrs.6808

Paper Development and characterisation of a new fluorescence sensor for online monitoring of bioprocesses

König, Jan Christoph; Steinwedel, Tobias; Solle, Dörte et al. · 2018 · Journal of sensors and sensor systems · DOI

Full title: Development and characterisation of a new fluorescence sensor for online monitoring of bioprocesses

Authors: König, Jan Christoph; Steinwedel, Tobias; Solle, Dörte; Lindner, Patrick; Vries, Ingo de; Hentrop, Thorleif; Findeis, Michael; John, Gernot T.; Scheper, Thomas; Beutel, Sascha

Year: 2018

Venue: Journal of sensors and sensor systems

DOI: https://doi.org/10.5194/jsss-7-461-2018

Paper A customized stand-alone photometric Raman sensor applicable in explosive atmospheres: a proof-of-concept study

Nachtmann, Marcel; Keck, Shaun; Braun, Frank et al. · 2018 · Journal of sensors and sensor systems · DOI

Full title: A customized stand-alone photometric Raman sensor applicable in explosive atmospheres: a proof-of-concept study

Authors: Nachtmann, Marcel; Keck, Shaun; Braun, Frank; Eckhardt, Hanns Simon; Mattolat, Christoph; Gretz, Norbert; Scholl, Stephan; Rädle, Matthias

Year: 2018

Venue: Journal of sensors and sensor systems

DOI: https://doi.org/10.5194/jsss-7-543-2018

Paper Machine Learning for Raman Spectroscopy-based Cyber-Marine Fish Biochemical Composition Analysis

Zhou, Yun; Chen, Gang; Xue, Bing et al. · 2024 · arXiv (Cornell University) · DOI

Full title: Machine Learning for Raman Spectroscopy-based Cyber-Marine Fish Biochemical Composition Analysis

Authors: Zhou, Yun; Chen, Gang; Xue, Bing; Zhang, Jun; Rooney, Jeremy S.; Lagutin, Kirill; MacKenzie, Andrew; Gordon, Keith C.; Killeen, Daniel P.

Year: 2024

Venue: arXiv (Cornell University)

DOI: https://doi.org/10.48550/arxiv.2409.19688

Paper PAT and automation strategies for the process development of PEGylated proteins

Sanden, Adrian Simon Johannes Marius · 2020 · Repository KITopen (Karlsruhe Institute of Technology) · DOI

Full title: PAT and automation strategies for the process development of PEGylated proteins

Authors: Sanden, Adrian Simon Johannes Marius

Year: 2020

Venue: Repository KITopen (Karlsruhe Institute of Technology)

DOI: https://doi.org/10.5445/ir/1000122597

Paper Simplified approaches to mid-infrared spectrometers calibration for bioprocess monitoring applications

Schenk, Jonas · 2007 · Infoscience (Ecole Polytechnique Fédérale de Lausanne) · DOI

Full title: Simplified approaches to mid-infrared spectrometers calibration for bioprocess monitoring applications

Authors: Schenk, Jonas

Year: 2007

Venue: Infoscience (Ecole Polytechnique Fédérale de Lausanne)

DOI: https://doi.org/10.5075/epfl-thesis-3917

Paper Applications of Machine Learning in Biopharmaceutical Process Development and Manufacturing: Current Trends, Challenges, and Opportunities

Khuat, Thanh Tung; Bassett, Robert; Otte, Ellen et al. · 2023 · arXiv (Cornell University) · DOI

Full title: Applications of Machine Learning in Biopharmaceutical Process Development and Manufacturing: Current Trends, Challenges, and Opportunities

Authors: Khuat, Thanh Tung; Bassett, Robert; Otte, Ellen; Grevis-James, Alistair; Gabryś, Bogdan

Year: 2023

Venue: arXiv (Cornell University)

DOI: https://doi.org/10.48550/arxiv.2310.09991

Paper Challenges and Emerging Technologies in Biomanufacturing of Monoclonal Antibodies (mAbs)

McDonnell, Susan; Principe, Raymon Floyd; Zamprognio, Maycou Soares et al. · 2022 · Biomedical engineering · DOI

Full title: Challenges and Emerging Technologies in Biomanufacturing of Monoclonal Antibodies (mAbs)

Authors: McDonnell, Susan; Principe, Raymon Floyd; Zamprognio, Maycou Soares; Whelan, Jessica

Year: 2022

Venue: Biomedical engineering

DOI: https://doi.org/10.5772/intechopen.108565

Paper Soft Sensors for Biomass Monitoring during Low Cost Cellulase Production

C. Murugan · 2021 · Biotechnological Applications of Biomass · DOI

Full title: Soft Sensors for Biomass Monitoring during Low Cost Cellulase Production

Authors: C. Murugan

Year: 2021

Venue: Biotechnological Applications of Biomass

DOI: https://doi.org/10.5772/intechopen.96027

Paper Process Analytical Technology (PAT) Model Lifecycle Management

McDermott, Larry · 2023 · Spectroscopy · DOI

Full title: Process Analytical Technology (PAT) Model Lifecycle Management

Authors: McDermott, Larry

Year: 2023

Venue: Spectroscopy

DOI: https://doi.org/10.56530/spectroscopy.pk3974j5

Paper Mathematical decomposition and multivariate analysis applied to Raman imaging

Holahan, Erin C. · 2024 · Library, Museums and Press - UDSpace (University of Delaware) · DOI

Full title: Mathematical decomposition and multivariate analysis applied to Raman imaging

Authors: Holahan, Erin C.

Year: 2024

Venue: Library, Museums and Press - UDSpace (University of Delaware)

DOI: https://doi.org/10.58088/vn5d-v207

Paper A Review on Progress and Potential of Machine Learning and AI in Pharmaceutical Development

Uriti, Sri Venkatesh · 2025 · Journal of Pharma Insights and Research. · DOI

Full title: A Review on Progress and Potential of Machine Learning and AI in Pharmaceutical Development

Authors: Uriti, Sri Venkatesh

Year: 2025

Venue: Journal of Pharma Insights and Research.

DOI: https://doi.org/10.69613/8pyky553

Paper Untitled

· 2024 · Indian Journal of Health Care Medical & Pharmacy Practice · DOI

Full title: Untitled

Year: 2024

Venue: Indian Journal of Health Care Medical & Pharmacy Practice

DOI: https://doi.org/10.59551/ijhmp/25832069/4.1.2023

Paper Spectroscopy as Process Analytical Technology for Preparative Protein Purification

Matthias Rüdt · 2019 · Prof. Dr. · DOI

Full title: Spectroscopy as Process Analytical Technology for Preparative Protein Purification

Authors: Matthias Rüdt

Year: 2019

Venue: Prof. Dr.

DOI: https://doi.org/10.5445/ir/1000089062

Paper HPLC in the Era of Biopharma: Advances in Column Chemistry, Automation and Data Analytics

Bhavanam, Nagajyothi · 2025 · Scientific Hub of Applied Research in Emerging Medical science & technology · DOI

Full title: HPLC in the Era of Biopharma: Advances in Column Chemistry, Automation and Data Analytics

Authors: Bhavanam, Nagajyothi

Year: 2025

Venue: Scientific Hub of Applied Research in Emerging Medical science & technology

DOI: https://doi.org/10.61096/shareme.v4.iss4.2025.142-152

Paper Quantitative analysis of glycerol concentration in red wine using Fourier transform infrared spectroscopy and chemometrics analysis

Joshi, Rahul; Joshi, Ritu; Amanah, Hanim Zuhrotul et al. · 2021 · Korean Journal of Agricultural Science · DOI

Full title: Quantitative analysis of glycerol concentration in red wine using Fourier transform infrared spectroscopy and chemometrics analysis

Authors: Joshi, Rahul; Joshi, Ritu; Amanah, Hanim Zuhrotul; Faqeerzada, Mohammad Akbar; Kumar, J.; Kim, Geonwoo; Baek, Insuck; Park, Eun-Sung; Masithoh, Rudiati Evi; Cho, Byoung–Kwan

Year: 2021

Venue: Korean Journal of Agricultural Science

DOI: https://doi.org/10.7744/kjoas.20210023

Paper An environmental metabolomics study of the effect of abiotic substances on Pseudomonas putida by employing analytical techniques

Sayqal, Ali · 2017 · Research Explorer (The University of Manchester)

Full title: An environmental metabolomics study of the effect of abiotic substances on Pseudomonas putida by employing analytical techniques

Authors: Sayqal, Ali

Year: 2017

Venue: Research Explorer (The University of Manchester)

Paper Advanced modelling, monitoring, and process control of bioconversion systems

Schmitt, Elliott · 2015 · ResearchWorks at the University of Washington (University of Washington)

Full title: Advanced modelling, monitoring, and process control of bioconversion systems

Authors: Schmitt, Elliott

Year: 2015

Venue: ResearchWorks at the University of Washington (University of Washington)

Paper Modelling Bacterial Growth for Applying Photodynamic Therapy with Indocyanine Green

Nguyen, Minh Quang · 2018 · Aaltodoc (Aalto University)

Full title: Modelling Bacterial Growth for Applying Photodynamic Therapy with Indocyanine Green

Authors: Nguyen, Minh Quang

Year: 2018

Venue: Aaltodoc (Aalto University)

Paper Assessment of Embryo Health and Circulating Tumor Cell Metabolism Using the Phasor-FLIM Approach

Ma, Ning · 2019 · eScholarship (California Digital Library)

Full title: Assessment of Embryo Health and Circulating Tumor Cell Metabolism Using the Phasor-FLIM Approach

Authors: Ma, Ning

Year: 2019

Venue: eScholarship (California Digital Library)

Paper Effect of mesenchymal stem cell source on the molecular profile of extracellular vesicles for cell therapy

Pires, Filipa · 2019 · Repositório Científico do Instituto Politécnico de Lisboa (Instituto Politécnico de Lisboa)

Full title: Effect of mesenchymal stem cell source on the molecular profile of extracellular vesicles for cell therapy

Authors: Pires, Filipa

Year: 2019

Venue: Repositório Científico do Instituto Politécnico de Lisboa (Instituto Politécnico de Lisboa)

Paper Development of Soft Sensors for Monitoring of Chinese Hamster Ovary Cell Processes

Ohadi, Seyed Kaveh · 2014 · UWSpace (University of Waterloo)

Full title: Development of Soft Sensors for Monitoring of Chinese Hamster Ovary Cell Processes

Authors: Ohadi, Seyed Kaveh

Year: 2014

Venue: UWSpace (University of Waterloo)

Paper Real time monitoring of the extraction process of Tagitinin C according to the physicochemical properties of supercritical CO2 by means of optical fibers coupling a FT-IR spectrometer and a supercritical fluid extractor

Eric, Ziemons, · 2006 · Open Repository and Bibliography (University of Liège)

Full title: Real time monitoring of the extraction process of Tagitinin C according to the physicochemical properties of supercritical CO2 by means of optical fibers coupling a FT-IR spectrometer and a supercritical fluid extractor

Authors: Eric, Ziemons,

Year: 2006

Venue: Open Repository and Bibliography (University of Liège)

Paper Investigating Protein Modifications Using Vibrational Spectroscopy and Fluorescence Spectroscopy.

Brewster, Victoria L. · 2013 · Research Portal (King's College London)

Full title: Investigating Protein Modifications Using Vibrational Spectroscopy and Fluorescence Spectroscopy.

Authors: Brewster, Victoria L.

Year: 2013

Venue: Research Portal (King's College London)

Paper Online Raman spectroscopy for bioprocess monitoring

Gil, Gustavo Adolfo · 2005 · DSpace@MIT (Massachusetts Institute of Technology)

Full title: Online Raman spectroscopy for bioprocess monitoring

Authors: Gil, Gustavo Adolfo

Year: 2005

Venue: DSpace@MIT (Massachusetts Institute of Technology)

Paper Seleção de variáveis baseada na integração de ranking de importância SVD com métodos de aprendizagem de máquina

Brito, João B. G. · 2020 · Lume (Universidade Federal do Rio Grande do Sul)

Full title: Seleção de variáveis baseada na integração de ranking de importância SVD com métodos de aprendizagem de máquina

Authors: Brito, João B. G.

Year: 2020

Venue: Lume (Universidade Federal do Rio Grande do Sul)

Paper Screening and Engineering Phenotypes using Big Data Systems Biology

Huttanus, Herbert M. · 2019 · VTechWorks (Virginia Tech)

Full title: Screening and Engineering Phenotypes using Big Data Systems Biology

Authors: Huttanus, Herbert M.

Year: 2019

Venue: VTechWorks (Virginia Tech)

Paper Single cell analysis and quantitative modelling of ion concentrations and dielectric properties of Chinese hamster ovary cells

Fazelkhah, Azita · 2020 · Mspace (University of Manitoba)

Full title: Single cell analysis and quantitative modelling of ion concentrations and dielectric properties of Chinese hamster ovary cells

Authors: Fazelkhah, Azita

Year: 2020

Venue: Mspace (University of Manitoba)

Paper Valorisation of olive mill solid waste through the production of volatile fatty acids within a biorefinery approach

Elena, Jiménez Páez, · 2025 · Institutional Repository of the University of Granada (University of Granada)

Full title: Valorisation of olive mill solid waste through the production of volatile fatty acids within a biorefinery approach

Authors: Elena, Jiménez Páez,

Year: 2025

Venue: Institutional Repository of the University of Granada (University of Granada)

Paper Sol-gel-derived optical oxygen, pH and dissolved carbon dioxide sensors

Wencel, Dorota · 2008 · Arrow@dit (Dublin Institute of Technology)

Full title: Sol-gel-derived optical oxygen, pH and dissolved carbon dioxide sensors

Authors: Wencel, Dorota

Year: 2008

Venue: Arrow@dit (Dublin Institute of Technology)

Paper Using Ft-Nir Spectroscopy To Automate Constant Sugar Concentration Fed-Batch Fermentations With Saccharomyces Cerevisiae: Effects On Cellular Viability And Kinetics Of Osmotic Stress Associated Metabolites

Frohman, Charles · 2013 · eCommons (Cornell University)

Full title: Using Ft-Nir Spectroscopy To Automate Constant Sugar Concentration Fed-Batch Fermentations With Saccharomyces Cerevisiae: Effects On Cellular Viability And Kinetics Of Osmotic Stress Associated Metabolites

Authors: Frohman, Charles

Year: 2013

Venue: eCommons (Cornell University)

Paper Untersuchung der Auswirkung verschiedener Umwelteinflüsse auf Mikroorganismen mittels ortsaufgelöster Raman-Spektroskopie

Münchberg, Ute · 2015 · Common Library Network (Der Gemeinsame Bibliotheksverbund)

Full title: Untersuchung der Auswirkung verschiedener Umwelteinflüsse auf Mikroorganismen mittels ortsaufgelöster Raman-Spektroskopie

Authors: Münchberg, Ute

Year: 2015

Venue: Common Library Network (Der Gemeinsame Bibliotheksverbund)

Thesis Implementation of process analytical technology (PAT) systems in manufacturing processes of liquid formulations

Brouckaert, Davinia · 2017 · Ghent University (Universiteit Gent) · DOI

Full title: Implementation of process analytical technology (PAT) systems in manufacturing processes of liquid formulations

Authors: Brouckaert, Davinia

Year: 2017

Venue: Ghent University (Universiteit Gent)

DOI: https://biblio.ugent.be/publication/8540958

Thesis Evaluation of accuracy dependence of Raman spectroscopic models on the ratio of calibration and validation points for non-invasive glucose sensing

Singh, Surya P; Mukherjee, Soumavo; Galindo, Luis H et al. · 2021 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Evaluation of accuracy dependence of Raman spectroscopic models on the ratio of calibration and validation points for non-invasive glucose sensing

Authors: Singh, Surya P; Mukherjee, Soumavo; Galindo, Luis H; So, Peter TC; Dasari, Ramachandra Rao; Khan, Uzma Zubair; Kannan, Raghuraman; Upendran, Anandhi; Kang, Jeon Woong

Year: 2021

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/135824

Thesis Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing

Soenksen Martinez, Luis Ruben; Kassis, Timothy; Noh, Minkyun et al. · 2018 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing

Authors: Soenksen Martinez, Luis Ruben; Kassis, Timothy; Noh, Minkyun; Griffith, Linda G; Trumper, David L

Year: 2018

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/116892

Thesis Industry 4.0 in Biomanufacturing: Predictive Real-Time Models Using Process Analytical Technology

Murr, Michaela · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Industry 4.0 in Biomanufacturing: Predictive Real-Time Models Using Process Analytical Technology

Authors: Murr, Michaela

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/151710

Thesis Chemometric techniques for multivariate calibration and their application in spectroscopic sensors

Ke, Wang · 2012 · Nanyang Technological University (NTU) · DOI

Full title: Chemometric techniques for multivariate calibration and their application in spectroscopic sensors

Authors: Ke, Wang

Year: 2012

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/48640

Thesis Analytical tools for monitoring and control of fermentation processes

Sundström, Heléne · 2007 · KTH Royal Institute of Technology · DOI

Full title: Analytical tools for monitoring and control of fermentation processes

Authors: Sundström, Heléne

Year: 2007

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4531

Thesis An Investigation of Multivariate Process Control for Biomanufacturing

Lui, Christopher A. · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: An Investigation of Multivariate Process Control for Biomanufacturing

Authors: Lui, Christopher A.

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/139505

Thesis PROCESS ANALYTICAL TECHNOLOGY APPROACHES FOR DAIRY INDUSTRY

STRANI, LORENZO · 2021 · Università degli Studi di Milano (AIR) · DOI

Full title: PROCESS ANALYTICAL TECHNOLOGY APPROACHES FOR DAIRY INDUSTRY

Authors: STRANI, LORENZO

Year: 2021

Venue: Università degli Studi di Milano (AIR)

DOI: http://hdl.handle.net/2434/814055

Thesis Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022 · KTH Royal Institute of Technology · DOI

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

Year: 2022

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Hong, Moo Sun · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Authors: Hong, Moo Sun

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/138943

Thesis Optical in-line biosensor for long-term continuous glucose monitoring and control in cell culture

Tric, Mircea · 2017 · Heidelberg University · DOI

Full title: Optical in-line biosensor for long-term continuous glucose monitoring and control in cell culture

Authors: Tric, Mircea

Year: 2017

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/23763/1/Dissertation%20Mircea%20Tric.pdf

Thesis Preemptive variation reduction in biologic drug substance manufacturing

Güereca Valdivia, Ismael · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Preemptive variation reduction in biologic drug substance manufacturing

Authors: Güereca Valdivia, Ismael

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/155982

Thesis Contact Free Monitoring of Cell Density in a Bioreactor with Magnetic Resonance Relaxometry

Gaensbauer, Hans · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Contact Free Monitoring of Cell Density in a Bioreactor with Magnetic Resonance Relaxometry

Authors: Gaensbauer, Hans

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/158512

Thesis Process Analytical Technology in biopharmaceutical manufacturing

Cosby, Samuel T. (Samuel Thomas) · 2013 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Process Analytical Technology in biopharmaceutical manufacturing

Authors: Cosby, Samuel T. (Samuel Thomas)

Year: 2013

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/80911

Thesis Wavelength selection-based nonlinear calibration for transcutaneous blood glucose sensing using Raman spectroscopy

Dingari, Narahara Chari; Barman, Ishan; Kang, Jeon Woong et al. · 2011 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Wavelength selection-based nonlinear calibration for transcutaneous blood glucose sensing using Raman spectroscopy

Authors: Dingari, Narahara Chari; Barman, Ishan; Kang, Jeon Woong; Kong, Chae-Ryon; Dasari, Ramachandra Rao; Feld, Michael S.

Year: 2011

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/67302

Thesis Smart Data Analytics for Manufacturing Processes

Mohr, Fabian · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Smart Data Analytics for Manufacturing Processes

Authors: Mohr, Fabian

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/155866

Thesis Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Maloney, Andrew John · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Authors: Maloney, Andrew John

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/158315

Thesis Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays

Rohskopf, Zhumei · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays

Authors: Rohskopf, Zhumei

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/152457

Thesis Automated Optimization and Control of Modular Chemical Systems

Nikolakopoulou, Anastasia · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Automated Optimization and Control of Modular Chemical Systems

Authors: Nikolakopoulou, Anastasia

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/143234

Thesis Effect of photobleaching on calibration model development in biological Raman spectroscopy

Barman, Ishan; Kong, Chae-Ryon; Singh, Gajendra P. et al. · 2011 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Effect of photobleaching on calibration model development in biological Raman spectroscopy

Authors: Barman, Ishan; Kong, Chae-Ryon; Singh, Gajendra P.; Dasari, Ramachandra Rao

Year: 2011

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/64970

Thesis Chemical Sensing as a Utility using Swept-Source Raman Spectroscopy

Persits, Nili · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Chemical Sensing as a Utility using Swept-Source Raman Spectroscopy

Authors: Persits, Nili

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/156629

Thesis Towards Using Portable NMR for Process Monitoring of Aqueous Turbulent Systems

Cutler, Brandon John · 2024 · University of California, Davis · DOI

Full title: Towards Using Portable NMR for Process Monitoring of Aqueous Turbulent Systems

Authors: Cutler, Brandon John

Year: 2024

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/30p745r6

Thesis Multiplexed microfluidics utilizing genome-scale dynamics for biosensing and fermentation monitoring

Stasiowski, Elizabeth · 2019 · University of California, San Diego (UCSD) · DOI

Full title: Multiplexed microfluidics utilizing genome-scale dynamics for biosensing and fermentation monitoring

Authors: Stasiowski, Elizabeth

Year: 2019

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/4n38g65x

Thesis Vibrational Spectroscopic Applications of Fourier Transform Infrared and Raman Spectroscopy in Biochemistry and Microbiology

Alrasheedi, Muneera · 2021 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Vibrational Spectroscopic Applications of Fourier Transform Infrared and Raman Spectroscopy in Biochemistry and Microbiology

Authors: Alrasheedi, Muneera

Year: 2021

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/30163/1/Muneera%20final%20PhD%20thesis%202021%20.pdf

Thesis The use of Raman spectroscopy for the live aseptic monitoring of stem cell differentiation

Mitchell, Adam James · 2014 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: The use of Raman spectroscopy for the live aseptic monitoring of stem cell differentiation

Authors: Mitchell, Adam James

Year: 2014

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/7616/1/ethesis%20final%20copy.pdf

Thesis Correlation of fermentation redox potential and induction of recombinant E. coli expression system

Guo, Jingjie 1990- · 2018 · University of Saskatchewan - HARVEST · DOI

Full title: Correlation of fermentation redox potential and induction of recombinant E. coli expression system

Authors: Guo, Jingjie 1990-

Year: 2018

Venue: University of Saskatchewan - HARVEST

DOI: http://hdl.handle.net/10388/11536

Thesis Gaussian Process Adaptive Soft Sensors and their Applications in Inferential Control Systems

Abusnina, Ali · 2014 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Gaussian Process Adaptive Soft Sensors and their Applications in Inferential Control Systems

Authors: Abusnina, Ali

Year: 2014

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/8870/19/EngD%20Thesis.pdf

Thesis On-line analysis of bacterial metabolism by modern spectroscopic laser techniques

Metcalfe, George Derek · 2022 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: On-line analysis of bacterial metabolism by modern spectroscopic laser techniques

Authors: Metcalfe, George Derek

Year: 2022

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/31732/1/George%20Derek%20Metcalfe%20PhD%20Thesis%20Minor%20Corrections.pdf

Thesis Microbial fuel cell-based biosensor for redox potential detection in fermentation process

Shen, Siyang · 2022 · University of Saskatchewan - HARVEST · DOI

Full title: Microbial fuel cell-based biosensor for redox potential detection in fermentation process

Authors: Shen, Siyang

Year: 2022

Venue: University of Saskatchewan - HARVEST

DOI: https://hdl.handle.net/10388/13798

Thesis Kinetic modelling of dissolution and crystallization of slurries with attenuated total reflectance UV-visible absorbance and near-infrared reflectance measurements

Hsieh, Chun; Billeter, Julien; McNally, Mary Ellen et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Kinetic modelling of dissolution and crystallization of slurries with attenuated total reflectance UV-visible absorbance and near-infrared reflectance measurements

Authors: Hsieh, Chun; Billeter, Julien; McNally, Mary Ellen; Hoffman, Ronald; Gemperline, Paul

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/85670

Thesis Kinetic modeling of dissolution of salicylic acid with in situ ATR UV-vis spectroscopy

Hsieh, Chun; Billeter, Julien; McNally, Mary Ellen et al. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Kinetic modeling of dissolution of salicylic acid with in situ ATR UV-vis spectroscopy

Authors: Hsieh, Chun; Billeter, Julien; McNally, Mary Ellen; Hoffman, Ronald; Gemperline, Paul

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76055

Thesis Kinetic modeling of dissolution and crystallization of batch reactions with in situ spectroscopic measurements

Hsieh, Chun; Billeter, Julien; McNally, Mary Ellen et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Kinetic modeling of dissolution and crystallization of batch reactions with in situ spectroscopic measurements

Authors: Hsieh, Chun; Billeter, Julien; McNally, Mary Ellen; Hoffman, Ronald; Gemperline, Paul

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76230

Thesis Real-time kinetic hard-modelling for the optimisation of reaction conditions and the detection of process upset in semi-batch reactors

Billeter, Julien; Neuhold, Yorck-Michael; Puxty, Graeme et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Real-time kinetic hard-modelling for the optimisation of reaction conditions and the detection of process upset in semi-batch reactors

Authors: Billeter, Julien; Neuhold, Yorck-Michael; Puxty, Graeme; Hungerbühler, Konrad

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/79407

Thesis In-Situ Bioreactor Monitoring and Control Based on Mid-Infrared Spectroscopic Measurements

Rhiel, M.; Valentinotti, S.; Amrhein, M. et al. · 2004 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: In-Situ Bioreactor Monitoring and Control Based on Mid-Infrared Spectroscopic Measurements

Authors: Rhiel, M.; Valentinotti, S.; Amrhein, M.; Cannizzaro, C.; Herwig, C.; Voisard, D.; Stark, D.; Bonvin, D.; Marison, I.; von Stockar, U.

Year: 2004

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/175459

Thesis Subspace Correction Methods in Multivariate Calibration

Gujral, Pamandeep Singh · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Subspace Correction Methods in Multivariate Calibration

Authors: Gujral, Pamandeep Singh

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/56274

Thesis Simplified approaches to mid-infrared spectrometers calibration for bioprocess monitoring applications

Schenk, Jonas · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Simplified approaches to mid-infrared spectrometers calibration for bioprocess monitoring applications

Authors: Schenk, Jonas

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/10286

Thesis Online optimisation and detection of process upset in semi-batch reactors using a kinetic modelling approach

Billeter, Julien; Neuhold, Yorck-Michael; Puxty, Graeme et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Online optimisation and detection of process upset in semi-batch reactors using a kinetic modelling approach

Authors: Billeter, Julien; Neuhold, Yorck-Michael; Puxty, Graeme; Hungerbühler, Konrad

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/79409

Thesis Cole-Cole, linear and multivariate modeling of capacitance data for on-line monitoring of biomass

Dabros, Michal; Dennewald, Danielle; Currie, David J. et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Cole-Cole, linear and multivariate modeling of capacitance data for on-line monitoring of biomass

Authors: Dabros, Michal; Dennewald, Danielle; Currie, David J.; Lee, Mark H.; Todd, Robert W.; Marison, Ian W.; von Stockar, U.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/58355

Thesis Electrochemical Biosensors for On-line Monitoring of Cell Culture Metabolism

Boero, Cristina · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Electrochemical Biosensors for On-line Monitoring of Cell Culture Metabolism

Authors: Boero, Cristina

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/87270

Thesis Evaluation of an online biomass probe to monitor cell growth and cell death.

Perani, A; Gloria, B; Wang, D et al. · 2022 · University of Melbourne · DOI

Full title: Evaluation of an online biomass probe to monitor cell growth and cell death.

Authors: Perani, A; Gloria, B; Wang, D; Buffier, A-S; Berteau, O; Esteban, G; Smyth, FE; Scott, AM

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/303929

Thesis DESIGN OF A SELF-CONSTRUCTED ELECTROCHEMICAL SYSTEM FOR HIGH SENSITIVITY DETECTION OF 9 MAJOR WATER-SOLUBLE VITAMINS AND DEGRADATION PRODUCTS IN MAMMALIAN CELL CULTURE MEDIA

Chen, Haiqi · 2024 · Johns Hopkins University · DOI

Full title: DESIGN OF A SELF-CONSTRUCTED ELECTROCHEMICAL SYSTEM FOR HIGH SENSITIVITY DETECTION OF 9 MAJOR WATER-SOLUBLE VITAMINS AND DEGRADATION PRODUCTS IN MAMMALIAN CELL CULTURE MEDIA

Authors: Chen, Haiqi

Year: 2024

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/69624

Thesis A Digital Approach to Model Quality and Sensory Traits of Beers Fermented under Sonication Based on Chemical Fingerprinting

Viejo, CG; Fuentes, S · 2021 · University of Melbourne · DOI

Full title: A Digital Approach to Model Quality and Sensory Traits of Beers Fermented under Sonication Based on Chemical Fingerprinting

Authors: Viejo, CG; Fuentes, S

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/274597

Thesis Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture

Shariatzadeh, M; Lopes, AG; Glen, KE et al. · 2021 · University of Melbourne · DOI

Full title: Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture

Authors: Shariatzadeh, M; Lopes, AG; Glen, KE; Sinclair, A; Thomas, RJ

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/289743

Thesis Predictive models for upstream mammalian cell culture development: a review

Yatipanthalawa, BS; Gras, SL · 2023 · University of Melbourne · DOI

Full title: Predictive models for upstream mammalian cell culture development: a review

Authors: Yatipanthalawa, BS; Gras, SL

Year: 2023

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/339523

Thesis Capturing prediction uncertainty in upstream cell culture models using conformal prediction and Gaussian processes

Pham, TD; Aickelin, U; Bassett, R · 2024 · University of Melbourne · DOI

Full title: Capturing prediction uncertainty in upstream cell culture models using conformal prediction and Gaussian processes

Authors: Pham, TD; Aickelin, U; Bassett, R

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/339627

Thesis Bioreactor Controls for High Oxygen Uptake Rate (OUR) Demand Processes

Cho, Hyun Woo · 2019 · Johns Hopkins University · DOI

Full title: Bioreactor Controls for High Oxygen Uptake Rate (OUR) Demand Processes

Authors: Cho, Hyun Woo

Year: 2019

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/60474

Thesis Data-driven soft sensing towards quality monitoring of industrial pasteurization processes

Filios, Gabriel; Kyriakopoulos, Andreas; Livanios, Stavros et al. · 2022 · University of Liverpool · DOI

Full title: Data-driven soft sensing towards quality monitoring of industrial pasteurization processes

Authors: Filios, Gabriel; Kyriakopoulos, Andreas; Livanios, Stavros; Manolopoulos, Fotis; Nikoletseas, Sotiris; Panagiotou, Stefanos H; Spirakis, Paul

Year: 2022

Venue: University of Liverpool

DOI: https://livrepository.liverpool.ac.uk/3156617/1/DCOSS22.pdf

Thesis A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments

Karimi Alavijeh, M; Lee, YY; Gras, SL · 2024 · University of Melbourne · DOI

Full title: A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments

Authors: Karimi Alavijeh, M; Lee, YY; Gras, SL

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/351093

Thesis Application of dielectric spectroscopy in an industrial bioprocess utilizing the baculovirus expression vector system

Brix, Alexander · 2016 · Kansas State University - K-REx · DOI

Full title: Application of dielectric spectroscopy in an industrial bioprocess utilizing the baculovirus expression vector system

Authors: Brix, Alexander

Year: 2016

Venue: Kansas State University - K-REx

DOI: http://hdl.handle.net/2097/32926

Thesis Enhancing beer authentication, quality, and control assessment using non-invasive spectroscopy through bottle and machine learning modeling

Harris, N; Gonzalez Viejo, C; Zhang, J et al. · 2025 · University of Melbourne · DOI

Full title: Enhancing beer authentication, quality, and control assessment using non-invasive spectroscopy through bottle and machine learning modeling

Authors: Harris, N; Gonzalez Viejo, C; Zhang, J; Pang, A; Hernandez-Brenes, C; Fuentes, S

Year: 2025

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/359649

Thesis Method development of flow cytometry analysis of yeast and lactic acid bacteria viability for alcohol fermentation

Komahan, Megha · 2023 · Lund University Student Papers · DOI

Full title: Method development of flow cytometry analysis of yeast and lactic acid bacteria viability for alcohol fermentation

Authors: Komahan, Megha

Year: 2023

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9125957

Thesis Probing Control in B. licheniformis Fermentations

Johnsson, Ola · 2010 · Lund University Student Papers · DOI

Full title: Probing Control in B. licheniformis Fermentations

Authors: Johnsson, Ola

Year: 2010

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/8847429

Thesis Using an Industrial Robot Arm for Monitoring Cultivations of Mammalian Cells in Pilot Scale

Poggendorf, Iris; Lütkemeyer, Dirk; Scherer, Torsten et al. · 2001 · Technical University of Munich (TUM) · DOI

Full title: Using an Industrial Robot Arm for Monitoring Cultivations of Mammalian Cells in Pilot Scale

Authors: Poggendorf, Iris;Lütkemeyer, Dirk;Scherer, Torsten;Zhang, Jianwei;Knoll, Alois;Lehmann, Jürgen

Year: 2001

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1290595

Thesis Perturbation-based Control of Industrial Fed-batch Bioprocesses

Johnsson, Ola · 2015 · Lund University (LUP) · DOI

Full title: Perturbation-based Control of Industrial Fed-batch Bioprocesses

Authors: Johnsson, Ola

Year: 2015

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/8412104

Thesis Real time estimations of kLa and viscosity in a fermentation pilot plant

Norberg, Arvid · 2022 · Lund University Student Papers · DOI

Full title: Real time estimations of kLa and viscosity in a fermentation pilot plant

Authors: Norberg, Arvid

Year: 2022

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9096296

Thesis APPLICATIONS OF METABOLOMICS APPROACHES FOR THE IMPROVEMENT OF MICROBIAL BIOPROCESS

Tengsuttiwat, Thanyaporn · 2025 · University of Liverpool · DOI

Full title: APPLICATIONS OF METABOLOMICS APPROACHES FOR THE IMPROVEMENT OF MICROBIAL BIOPROCESS

Authors: Tengsuttiwat, Thanyaporn

Year: 2025

Venue: University of Liverpool

DOI: https://livrepository.liverpool.ac.uk/3192146/1/201453891_Sep2024.pdf

Thesis FIA-Based Process Monitoring in Simulated Bioreactor for Monoclonal Antibody Production

Fernandez Alcantara, Leonardo Renzo · 2025 · Lund University Student Papers · DOI

Full title: FIA-Based Process Monitoring in Simulated Bioreactor for Monoclonal Antibody Production

Authors: Fernandez Alcantara, Leonardo Renzo

Year: 2025

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9188201

Thesis Biosensors and Automation for Bioprocess Monitoring and Control

Kumar, M A · 2011 · Lund University (LUP) · DOI

Full title: Biosensors and Automation for Bioprocess Monitoring and Control

Authors: Kumar, M A

Year: 2011

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/1737382

Thesis Ultrasound based PAT-concept for online monitoring of fermentative bioprocesses.

Hoche, Sven · 2018 · Technical University of Munich (TUM) · DOI

Full title: Ultrasound based PAT-concept for online monitoring of fermentative bioprocesses.

Authors: Hoche, Sven

Year: 2018

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1327420

Thesis Biomass soft sensor for a Pichia pastoris fed‐batch process based on phase detection and hybrid modeling

Brunner, Vincent; Siegl, Manuel; Geier, Dominik et al. · 2020 · Technical University of Munich (TUM) · DOI

Full title: Biomass soft sensor for a Pichia pastoris fed‐batch process based on phase detection and hybrid modeling

Authors: Brunner, Vincent;Siegl, Manuel;Geier, Dominik;Becker, Thomas

Year: 2020

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1576014

Thesis Computationally aided reliability analysis of sensor data using multivariate data analysis and modelling approaches for bioprocesses

Krause, Daniel · 2018 · Technical University of Munich (TUM) · DOI

Full title: Computationally aided reliability analysis of sensor data using multivariate data analysis and modelling approaches for bioprocesses

Authors: Krause, Daniel

Year: 2018

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1364668

Thesis Mathematially based management of Saccharomyces sp. batch propagations and fermentations

Kurz, Tomas · 2005 · Technical University of Munich · DOI

Full title: Mathematially based management of Saccharomyces sp. batch propagations and fermentations

Authors: Kurz, Tomas

Year: 2005

Venue: Technical University of Munich

DOI: https://mediatum.ub.tum.de/603297

Thesis Metabolic Profiling of Mesenchymal Stromal Cells for Critical Quality Attribute Identification

Maughon, Ty · 2024 · University of Georgia - UGA Open Scholar · DOI

Full title: Metabolic Profiling of Mesenchymal Stromal Cells for Critical Quality Attribute Identification

Authors: Maughon, Ty

Year: 2024

Venue: University of Georgia - UGA Open Scholar

DOI: https://openscholar.uga.edu/record/3044/files/MaughonTimothyPHD.pdf

Thesis Phenotypic and Metabolic Profiling of Biological Samples in Near Real-Time Using Raman Spectroscopy

Zu, Theresah Nom Korbieh · 2016 · Virginia Tech - VTechWorks · DOI

Full title: Phenotypic and Metabolic Profiling of Biological Samples in Near Real-Time Using Raman Spectroscopy

Authors: Zu, Theresah Nom Korbieh

Year: 2016

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/65153

Thesis Machine Learning and Multivariate Statistics for Optimizing Bioprocessing and Polyolefin Manufacturing

Agarwal, Aman · 2022 · Virginia Tech - VTechWorks · DOI

Full title: Machine Learning and Multivariate Statistics for Optimizing Bioprocessing and Polyolefin Manufacturing

Authors: Agarwal, Aman

Year: 2022

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/107480

Thesis Data Analytics and Machine Learning Applications in Fermentation Processes and Molecular Property Prediction

Nguyen, Xuan Dung · 2025 · Virginia Tech - VTechWorks · DOI

Full title: Data Analytics and Machine Learning Applications in Fermentation Processes and Molecular Property Prediction

Authors: Nguyen, Xuan Dung

Year: 2025

Venue: Virginia Tech - VTechWorks

DOI: https://hdl.handle.net/10919/134219

Thesis Compressive Sensing Approaches for Sensor based Predictive Analytics in Manufacturing and Service Systems

Bastani, Kaveh · 2016 · Virginia Tech - VTechWorks · DOI

Full title: Compressive Sensing Approaches for Sensor based Predictive Analytics in Manufacturing and Service Systems

Authors: Bastani, Kaveh

Year: 2016

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/64917

Thesis Miniaturisation of pH Holographic Sensors for Nano-Bioreactors

Chan, Leon, Cong Zhi · 2017 · University of Cambridge · DOI

Full title: Miniaturisation of pH Holographic Sensors for Nano-Bioreactors

Authors: Chan, Leon, Cong Zhi

Year: 2017

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/268167

Thesis Neural Networks in Bioprocessing and Chemical Engineering

Baughman, D. Richard · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Neural Networks in Bioprocessing and Chemical Engineering

Authors: Baughman, D. Richard

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/29061

Thesis Design and Fabrication of Piezoelectric Sensors and Actuators for Characterization of Soft Materials

Cesewski, Ellen · 2022 · Virginia Tech - VTechWorks · DOI

Full title: Design and Fabrication of Piezoelectric Sensors and Actuators for Characterization of Soft Materials

Authors: Cesewski, Ellen

Year: 2022

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/108758

Thesis Mid-Infrared Integrated Devices for Optical Chemical Sensing

Alimagham, Farah Christina · 2020 · University of Cambridge · DOI

Full title: Mid-Infrared Integrated Devices for Optical Chemical Sensing

Authors: Alimagham, Farah Christina

Year: 2020

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/307700

Thesis Virtualization and real-time analysis of pharmaceutical and food products by near infrared spectroscopy

Sun, Dong · 2018 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Virtualization and real-time analysis of pharmaceutical and food products by near infrared spectroscopy

Authors: Sun, Dong

Year: 2018

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/459155

Thesis Development of analytical methods based on Near Infrared Spectroscopy for monitoring of pharmaceutical and biotechnological processes and control of new psychoactive substances

Miró Vera, Aira Yira · 2020 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Development of analytical methods based on Near Infrared Spectroscopy for monitoring of pharmaceutical and biotechnological processes and control of new psychoactive substances

Authors: Miró Vera, Aira Yira

Year: 2020

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/669569

Thesis Development of new analytical methods using Near Infrared and Chemometrics for pharmaceutical quality control: Enhancement of modelling strategies towards a better product understanding

Cárdenas Espitia, Vanessa · 2016 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Development of new analytical methods using Near Infrared and Chemometrics for pharmaceutical quality control: Enhancement of modelling strategies towards a better product understanding

Authors: Cárdenas Espitia, Vanessa

Year: 2016

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/377466

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Metadata only

Paper Towards a digital twin: a hybrid data‐driven and mechanistic digital shadow to forecast the evolution of lignocellulosic fermentation

López, Pau Cabañeros; Udugama, Isuru A.; Thomsen, Sune Tjalfe et al. · 2020 · Biofuels Bioproducts and Biorefining · DOI

Full title: Towards a digital twin: a hybrid data‐driven and mechanistic digital shadow to forecast the evolution of lignocellulosic fermentation

Authors: López, Pau Cabañeros; Udugama, Isuru A.; Thomsen, Sune Tjalfe; Roslander, Christian; Junicke, Helena; Mauricio‐Iglesias, Miguel; Gernaey, Krist V.

Year: 2020

Venue: Biofuels Bioproducts and Biorefining

DOI: https://doi.org/10.1002/bbb.2108

Paper Design of a microfluidic mixer channel: First steps into creating a fluorescent dye-based biosensor for mAb aggregate detection.

São Pedro, Mariana N; Santos, Mafalda S; Eppink, Michel H M et al. · 2023 · Biotechnology journal · DOI

Full title: Design of a microfluidic mixer channel: First steps into creating a fluorescent dye-based biosensor for mAb aggregate detection.

Authors: São Pedro, Mariana N; Santos, Mafalda S; Eppink, Michel H M; Ottens, Marcel

Year: 2023

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202200332

Paper Intelligent process development — An in‐line Raman‐assisted automatic cell culture process development platform

Zhijun Zhang; Zhe Lang; Gong Chen et al. · 2025 · AIChE Journal · DOI

Full title: Intelligent process development — An in‐line Raman‐assisted automatic cell culture process development platform

Authors: Zhijun Zhang; Zhe Lang; Gong Chen; Mingyue Fang; Hang Zhou; Weichang Zhou

Year: 2025

Venue: AIChE Journal

DOI: https://doi.org/10.1002/aic.18851

Paper Opportunities and challenges of real-time release testing in biopharmaceutical manufacturing.

Jiang, Mo; Severson, Kristen A; Love, John Christopher et al. · 2017 · Biotechnology and bioengineering · DOI

Full title: Opportunities and challenges of real-time release testing in biopharmaceutical manufacturing.

Authors: Jiang, Mo; Severson, Kristen A; Love, John Christopher; Madden, Helena; Swann, Patrick; Zang, Li; Braatz, Richard D

Year: 2017

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.26383

Paper Localized Sampling Enables Monitoring of Cell State via Inline Electrospray Ionization Mass Spectrometry

Mason A Chilmonczyk; Gilad Doron; P. Kottke et al. · 2020 · Biotechnology Journal · DOI

Full title: Localized Sampling Enables Monitoring of Cell State via Inline Electrospray Ionization Mass Spectrometry

Authors: Mason A Chilmonczyk; Gilad Doron; P. Kottke; A. Culberson; Kelly E Leguineche; R. Guldberg; E. Horwitz; A. Fedorov

Year: 2020

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202000277

Paper Hybrid Modeling and Intensified DoE: An Approach to Accelerate Upstream Process Characterization

Bayer, Benjamin; Striedner, Gerald; Duerkop, Mark · 2020 · Biotechnology Journal · DOI

Full title: Hybrid Modeling and Intensified DoE: An Approach to Accelerate Upstream Process Characterization

Authors: Bayer, Benjamin; Striedner, Gerald; Duerkop, Mark

Year: 2020

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202000121

Paper Label‐free live cell imaging by Confocal Raman Microscopy identifies CHO host and producer cell lines

Mateu, Batirtze Prats; Harreither, Eva; Schosserer, Markus et al. · 2016 · Biotechnology Journal · DOI

Full title: Label‐free live cell imaging by Confocal Raman Microscopy identifies CHO host and producer cell lines

Authors: Mateu, Batirtze Prats; Harreither, Eva; Schosserer, Markus; Puxbaum, Verena; Gludovacz, Elisabeth; Borth, Nicole; Gierlinger, Notburga; Grillari, Johannes

Year: 2016

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.201600037

Paper Quality by control: Towards model predictive control of mammalian cell culture bioprocesses.

Sommeregger, Wolfgang; Sissolak, Bernhard; Kandra, Kulwant et al. · 2017 · Biotechnology journal · DOI

Full title: Quality by control: Towards model predictive control of mammalian cell culture bioprocesses.

Authors: Sommeregger, Wolfgang; Sissolak, Bernhard; Kandra, Kulwant; von Stosch, Moritz; Mayer, Martin; Striedner, Gerald

Year: 2017

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201600546

Paper Automatic Assay Preparation Platform (A2P2) for Real-Time Critical Quality Attributes Monitoring of Cell Culture Samples.

Chan, Pik K; Wu, Chao-Hsiang Richard; Duan, Yaokai et al. · 2025 · Biotechnology journal · DOI

Full title: Automatic Assay Preparation Platform (A2P2) for Real-Time Critical Quality Attributes Monitoring of Cell Culture Samples.

Authors: Chan, Pik K; Wu, Chao-Hsiang Richard; Duan, Yaokai; Song, Jiu-Li; Goudar, Chetan T

Year: 2025

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.70082

Paper Enhancing cross‐scale Raman in‐line monitoring capability of cell culture process in large‐scale manufacturing

Lang, Zhe; Chen, Gong; Yan, Shaofan et al. · 2024 · AIChE Journal · DOI

Full title: Enhancing cross‐scale Raman in‐line monitoring capability of cell culture process in large‐scale manufacturing

Authors: Lang, Zhe; Chen, Gong; Yan, Shaofan; Zhang, Zhijun; Yang, Yang; Tang, Ziran; Zhu, Huilin; Dong, S.B.; Zhou, Hang; Zhou, Weichang

Year: 2024

Venue: AIChE Journal

DOI: https://doi.org/10.1002/aic.18608

Paper Explainable deep learning enhances robust and reliable real‐time monitoring of a chromatographic protein A capture step

Medl, Matthias; Leisch, Friedrich; Dürauer, Astrid et al. · 2024 · Biotechnology Journal · DOI

Full title: Explainable deep learning enhances robust and reliable real‐time monitoring of a chromatographic protein A capture step

Authors: Medl, Matthias; Leisch, Friedrich; Dürauer, Astrid; Scharl, Theresa

Year: 2024

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202300554

Paper Bridging the gap between PAT concepts and implementation: An integrated software platform for fermentation.

Chopda, Viki R; Gomes, James; Rathore, Anurag S · 2016 · Biotechnology journal · DOI

Full title: Bridging the gap between PAT concepts and implementation: An integrated software platform for fermentation.

Authors: Chopda, Viki R; Gomes, James; Rathore, Anurag S

Year: 2016

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201500507

Paper Capacitance spectroscopy enables real-time monitoring of early cell death in mammalian cell culture.

Wu, Suyang; Ketcham, Stephanie A; Corredor, Claudia C et al. · 2023 · Biotechnology journal · DOI

Full title: Capacitance spectroscopy enables real-time monitoring of early cell death in mammalian cell culture.

Authors: Wu, Suyang; Ketcham, Stephanie A; Corredor, Claudia C; Both, Douglas; Drennen, James K; Anderson, Carl A

Year: 2023

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202200231

Paper Influence of cell specific parameters in a dielectric spectroscopy conversion model used to monitor viable cell density in bioreactors

Schini, Adèle; Canditiis, B. De; Sanchez, Célia et al. · 2023 · Biotechnology Journal · DOI

Full title: Influence of cell specific parameters in a dielectric spectroscopy conversion model used to monitor viable cell density in bioreactors

Authors: Schini, Adèle; Canditiis, B. De; Sanchez, Célia; Pierrelée, Michaël; Voltz, Karine‐Elise; Jourdainne, Laurent

Year: 2023

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202300028

Paper Process‐induced cell cycle oscillations in CHO cultures: Online monitoring and model‐based investigation

Möller, Johannes; Bhat, Krathika; Riecken, Kristoffer et al. · 2019 · Biotechnology and Bioengineering · DOI

Full title: Process‐induced cell cycle oscillations in CHO cultures: Online monitoring and model‐based investigation

Authors: Möller, Johannes; Bhat, Krathika; Riecken, Kristoffer; Pörtner, Ralf; Zeng, An‐Ping; Jandt, Uwe

Year: 2019

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27124

Paper Process analytical technology and compensating for nonlinear effects in process spectroscopic data for improved process monitoring and control

Chen, Zeng‐Ping; Morris, Julian · 2009 · Biotechnology Journal · DOI

Full title: Process analytical technology and compensating for nonlinear effects in process spectroscopic data for improved process monitoring and control

Authors: Chen, Zeng‐Ping; Morris, Julian

Year: 2009

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.200800314

Paper Influence of Produced Water and Light Irradiation on the Composition of Exopolysaccharide Produced by L. amnigena Evaluated by Raman Spectroscopy

Silva, Anna Paula L. T. da; Soares, Luiz Guilherme P.; Gulberg, Lars Duarte et al. · 2025 · Biopolymers · DOI

Full title: Influence of Produced Water and Light Irradiation on the Composition of Exopolysaccharide Produced by L. amnigena Evaluated by Raman Spectroscopy

Authors: Silva, Anna Paula L. T. da; Soares, Luiz Guilherme P.; Gulberg, Lars Duarte; Crugeira, Pedro Jorge Louro; Almeida, Paulo Fernando de; Fernandes, Adjaci Uchôa; Silveira, Landulfo; Pinheiro, Antônio Luiz Barbosa

Year: 2025

Venue: Biopolymers

DOI: https://doi.org/10.1002/bip.70022

Paper Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe.

Abu-Absi, Nicholas R; Kenty, Brian M; Cuellar, Maryann Ehly et al. · 2011 · Biotechnology and bioengineering · DOI

Full title: Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe.

Authors: Abu-Absi, Nicholas R; Kenty, Brian M; Cuellar, Maryann Ehly; Borys, Michael C; Sakhamuri, Sivakesava; Strachan, David J; Hausladen, Michael C; Li, Zheng Jian

Year: 2011

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.23023

Paper Advanced process monitoring and feedback control to enhance cell culture process production and robustness.

Zhang, An; Tsang, Valerie Liu; Moore, Brandon et al. · 2015 · Biotechnology and bioengineering · DOI

Full title: Advanced process monitoring and feedback control to enhance cell culture process production and robustness.

Authors: Zhang, An; Tsang, Valerie Liu; Moore, Brandon; Shen, Vivian; Huang, Yao-Ming; Kshirsagar, Rashmi; Ryll, Thomas

Year: 2015

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.25684

Paper Advances in bioreactor control for production of biotherapeutic products.

Nikita, Saxena; Mishra, Somesh; Gupta, Keshari et al. · 2023 · Biotechnology and bioengineering · DOI

Full title: Advances in bioreactor control for production of biotherapeutic products.

Authors: Nikita, Saxena; Mishra, Somesh; Gupta, Keshari; Runkana, Venkataramana; Gomes, James; Rathore, Anurag S

Year: 2023

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28346

Paper A multisensor approach for improved protein A load phase monitoring by conductivity‐based background subtraction of UV spectra

Rolinger, Laura; Rüdt, Matthias; Hubbuch, Jürgen · 2020 · Biotechnology and Bioengineering · DOI

Full title: A multisensor approach for improved protein A load phase monitoring by conductivity‐based background subtraction of UV spectra

Authors: Rolinger, Laura; Rüdt, Matthias; Hubbuch, Jürgen

Year: 2020

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27616

Paper Online/at-line measurement, analysis and control of product titer and critical product quality attributes (CQAs) during process development.

Chemmalil, Letha; Prabhakar, Tanushree; Kuang, June et al. · 2020 · Biotechnology and bioengineering · DOI

Full title: Online/at-line measurement, analysis and control of product titer and critical product quality attributes (CQAs) during process development.

Authors: Chemmalil, Letha; Prabhakar, Tanushree; Kuang, June; West, Jay; Tan, Zhijun; Ehamparanathan, Vivekh; Song, Yuanli; Xu, Jianlin; Ding, Julia; Li, Zhengjian

Year: 2020

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.27531

Paper Process analytical technology implementation for protein refolding: GCSF as a case study.

Hebbi, Vishwanath; Thakur, Garima; Rathore, Anurag S · 2019 · Biotechnology and bioengineering · DOI

Full title: Process analytical technology implementation for protein refolding: GCSF as a case study.

Authors: Hebbi, Vishwanath; Thakur, Garima; Rathore, Anurag S

Year: 2019

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.26900

Paper Impacts on product quality attributes of monoclonal antibodies produced in CHO cell bioreactor cultures during intentional mycoplasma contamination events

Fratz‐Berilla, Erica J.; Angart, Phillip; Graham, Ryan J. et al. · 2020 · Biotechnology and Bioengineering · DOI

Full title: Impacts on product quality attributes of monoclonal antibodies produced in CHO cell bioreactor cultures during intentional mycoplasma contamination events

Authors: Fratz‐Berilla, Erica J.; Angart, Phillip; Graham, Ryan J.; Powers, David N.; Mohammad, Adil; Kohnhorst, Casey; Faison, Talia; Velugula‐Yellela, Sai Rashmika; Trunfio, Nicholas; Agarabi, Cyrus

Year: 2020

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27436

Paper Model‐based control system design to manage process parameters in mammalian cell culture for biopharmaceutical manufacturing

Sakaki, Ayumu; Namatame, Tetsushi; Nakaya, Makoto et al. · 2023 · Biotechnology and Bioengineering · DOI

Full title: Model‐based control system design to manage process parameters in mammalian cell culture for biopharmaceutical manufacturing

Authors: Sakaki, Ayumu; Namatame, Tetsushi; Nakaya, Makoto; Ōmasa, Takeshi

Year: 2023

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28593

Paper Online monitoring and control of upstream cell culture process using 1D and 2D-LC with SegFlow interface.

Chemmalil, Letha; Wasalathanthri, Dhanuka P; Zhang, Xin et al. · 2021 · Biotechnology and bioengineering · DOI

Full title: Online monitoring and control of upstream cell culture process using 1D and 2D-LC with SegFlow interface.

Authors: Chemmalil, Letha; Wasalathanthri, Dhanuka P; Zhang, Xin; Kuang, June; Shao, Chun; Barbour, Robin; Bhavsar, Sohil; Prabhakar, Tanushree; Knihtila, Ryan; West, Jay; Puri, Neha; McHugh, Kyle; Rehmann, Matthew S; He, Qin; Xu, Jianlin; Borys, Michael C; Ding, Julia; Li, Zhengjian

Year: 2021

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.27873

Paper Technology outlook for real-time quality attribute and process parameter monitoring in biopharmaceutical development-A review.

Wasalathanthri, Dhanuka P; Rehmann, Matthew S; Song, Yuanli et al. · 2020 · Biotechnology and bioengineering · DOI

Full title: Technology outlook for real-time quality attribute and process parameter monitoring in biopharmaceutical development-A review.

Authors: Wasalathanthri, Dhanuka P; Rehmann, Matthew S; Song, Yuanli; Gu, Yan; Mi, Luo; Shao, Chun; Chemmalil, Letha; Lee, Jongchan; Ghose, Sanchayita; Borys, Michael C; Ding, Julia; Li, Zheng Jian

Year: 2020

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.27461

Paper Transforming data to information: A parallel hybrid model for real‐time state estimation in lignocellulosic ethanol fermentation

López, Pau Cabañeros; Udugama, Isuru A.; Thomsen, Sune Tjalfe et al. · 2020 · Biotechnology and Bioengineering · DOI

Full title: Transforming data to information: A parallel hybrid model for real‐time state estimation in lignocellulosic ethanol fermentation

Authors: López, Pau Cabañeros; Udugama, Isuru A.; Thomsen, Sune Tjalfe; Roslander, Christian; Junicke, Helena; Mauricio‐Iglesias, Miguel; Gernaey, Krist V.

Year: 2020

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27586

Paper Methodology for real‐time, multianalyte monitoring of fermentations using an in‐situ mid‐infrared sensor

Kornmann, Henri; Rhiel, Martin; Cannizzaro, Christopher et al. · 2003 · Biotechnology and Bioengineering · DOI

Full title: Methodology for real‐time, multianalyte monitoring of fermentations using an in‐situ mid‐infrared sensor

Authors: Kornmann, Henri; Rhiel, Martin; Cannizzaro, Christopher; Marison, I. W.; Stockar, Urs von

Year: 2003

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.10618

Paper Development of a rapid polarized total synchronous fluorescence spectroscopy (pTSFS) method for protein quantification in a model bioreactor broth

Boateng, Bernard O.; Elcoroaristizabal, Saioa; Ryder, Alan G. · 2021 · Biotechnology and Bioengineering · DOI

Full title: Development of a rapid polarized total synchronous fluorescence spectroscopy (pTSFS) method for protein quantification in a model bioreactor broth

Authors: Boateng, Bernard O.; Elcoroaristizabal, Saioa; Ryder, Alan G.

Year: 2021

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27694

Paper On‐line untargeted metabolomics monitoring of an Escherichia coli succinate fermentation process

Cortada‐Garcia, Joan; Haggarty, Jennifer; Moses, Tessa et al. · 2022 · Biotechnology and Bioengineering · DOI

Full title: On‐line untargeted metabolomics monitoring of an Escherichia coli succinate fermentation process

Authors: Cortada‐Garcia, Joan; Haggarty, Jennifer; Moses, Tessa; Daly, Rónán; Arnold, S. Alison; Burgess, Karl

Year: 2022

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28173

Paper Application of green analytical chemistry to a green chemistry process: Magnetic resonance and Raman spectroscopic process monitoring of continuous ethanolic fermentation

Legner, Robin; Wirtz, Alexander; Koza, Tim et al. · 2019 · Biotechnology and Bioengineering · DOI

Full title: Application of green analytical chemistry to a green chemistry process: Magnetic resonance and Raman spectroscopic process monitoring of continuous ethanolic fermentation

Authors: Legner, Robin; Wirtz, Alexander; Koza, Tim; Tetzlaff, Till K.; Nickisch‐Hartfiel, Anna; Jaeger, Martin

Year: 2019

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27112

Paper Comparison of UV‐ and Raman‐based monitoring of the Protein A load phase and evaluation of data fusion by PLS models and CNNs

Rolinger, Laura; Rüdt, Matthias; Hubbuch, Jürgen · 2021 · Biotechnology and Bioengineering · DOI

Full title: Comparison of UV‐ and Raman‐based monitoring of the Protein A load phase and evaluation of data fusion by PLS models and CNNs

Authors: Rolinger, Laura; Rüdt, Matthias; Hubbuch, Jürgen

Year: 2021

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27894

Paper Robotic integration enables autonomous operation of laboratory scale stirred tank bioreactors with model‐driven process analysis

Morschett, Holger; Tenhaef, Niklas; Hemmerich, Johannes et al. · 2021 · Biotechnology and Bioengineering · DOI

Full title: Robotic integration enables autonomous operation of laboratory scale stirred tank bioreactors with model‐driven process analysis

Authors: Morschett, Holger; Tenhaef, Niklas; Hemmerich, Johannes; Herbst, Laura; Spiertz, Markus; Doğan, Deniz; Wiechert, Wolfgang; Noack, Stephan; Oldiges, Marco

Year: 2021

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27795

Paper Cell culture product quality attribute prediction using convolutional neural networks and Raman spectroscopy

Khodabandehlou, Hamid; Rashedi, Mohammad; Wang, Tony et al. · 2024 · Biotechnology and Bioengineering · DOI

Full title: Cell culture product quality attribute prediction using convolutional neural networks and Raman spectroscopy

Authors: Khodabandehlou, Hamid; Rashedi, Mohammad; Wang, Tony; Tulsyan, Aditya; Schorner, Gregg; Garvin, Christopher; Ündey, Cenk

Year: 2024

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28646

Paper Control of surge tanks for continuous manufacturing of monoclonal antibodies.

Thakur, Garima; Nikita, Saxena; Tiwari, Anamika et al. · 2021 · Biotechnology and bioengineering · DOI

Full title: Control of surge tanks for continuous manufacturing of monoclonal antibodies.

Authors: Thakur, Garima; Nikita, Saxena; Tiwari, Anamika; Rathore, Anurag S

Year: 2021

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.27706

Paper Bioprocess in-line monitoring using Raman spectroscopy and Indirect Hard Modeling (IHM): A simple calibration yields a robust model.

Müller, David Heinrich; Flake, Carsten; Brands, Thorsten et al. · 2023 · Biotechnology and bioengineering · DOI

Full title: Bioprocess in-line monitoring using Raman spectroscopy and Indirect Hard Modeling (IHM): A simple calibration yields a robust model.

Authors: Müller, David Heinrich; Flake, Carsten; Brands, Thorsten; Koß, Hans-Jürgen

Year: 2023

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28424

Paper A low‐temperature SPR‐based assay for monoclonal antibody galactosylation and fucosylation assessment using FcγRIIA/B

J. Gaudreault; Catherine Forest-Nault; Michel Gilbert et al. · 2024 · Biotechnology and Bioengineering · DOI

Full title: A low‐temperature SPR‐based assay for monoclonal antibody galactosylation and fucosylation assessment using FcγRIIA/B

Authors: J. Gaudreault; Catherine Forest-Nault; Michel Gilbert; Yves Durocher; Olivier Henry; G. De Crescenzo

Year: 2024

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28673

Paper Real‐time detection of mAb aggregates in an integrated downstream process

Pedro, Mariana N. São; Isaksson, M.; Gomis‐Fons, Joaquín et al. · 2023 · Biotechnology and Bioengineering · DOI

Full title: Real‐time detection of mAb aggregates in an integrated downstream process

Authors: Pedro, Mariana N. São; Isaksson, M.; Gomis‐Fons, Joaquín; Eppink, Michel H. M.; Nilsson, Bernt; Ottens, Marcel

Year: 2023

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28466

Paper Automated calibration and in‐line measurement of product quality during therapeutic monoclonal antibody purification using Raman spectroscopy

Wang, Jiarui; Chen, Jingyi; Studts, Joey et al. · 2023 · Biotechnology and Bioengineering · DOI

Full title: Automated calibration and in‐line measurement of product quality during therapeutic monoclonal antibody purification using Raman spectroscopy

Authors: Wang, Jiarui; Chen, Jingyi; Studts, Joey; Wang, Gang

Year: 2023

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28514

Paper Nonlinear state estimation as tool for online monitoring and adaptive feed in high throughput cultivations

Kemmer, Annina; Fischer, N.H.; Wilms, Terrance et al. · 2023 · Biotechnology and Bioengineering · DOI

Full title: Nonlinear state estimation as tool for online monitoring and adaptive feed in high throughput cultivations

Authors: Kemmer, Annina; Fischer, N.H.; Wilms, Terrance; Cai, Linda; Groß, Sebastian; King, Rudibert; Neubauer, Peter; Bournazou, Mariano Nicolás Cruz

Year: 2023

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28509

Paper Integration of just‐in‐time learning with variational autoencoder for cell culture process monitoring based on Raman spectroscopy

Rashedi, Mohammad; Khodabandehlou, Hamid; Wang, Tony et al. · 2024 · Biotechnology and Bioengineering · DOI

Full title: Integration of just‐in‐time learning with variational autoencoder for cell culture process monitoring based on Raman spectroscopy

Authors: Rashedi, Mohammad; Khodabandehlou, Hamid; Wang, Tony; Demers, Matthew; Tulsyan, Aditya; Garvin, Christopher; Ündey, Cenk

Year: 2024

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28713

Paper Monitoring of the Biotechnological Production of Dihydroxyacetone Using a Low‐Field 1H NMR Spectrometer

Mahler, Lukas; Tasdemir, Ebru; Nickisch‐Hartfiel, Anna et al. · 2024 · Biotechnology and Bioengineering · DOI

Full title: Monitoring of the Biotechnological Production of Dihydroxyacetone Using a Low‐Field 1H NMR Spectrometer

Authors: Mahler, Lukas; Tasdemir, Ebru; Nickisch‐Hartfiel, Anna; Mayer, Christian; Jaeger, Martin

Year: 2024

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28901

Paper Bioprocess in‐line monitoring and control using Raman spectroscopy and Indirect Hard Modeling (IHM)

D. H. Müller; Marieke Börger; J. Thien et al. · 2024 · Biotechnology and Bioengineering · DOI

Full title: Bioprocess in‐line monitoring and control using Raman spectroscopy and Indirect Hard Modeling (IHM)

Authors: D. H. Müller; Marieke Börger; J. Thien; H. Koß

Year: 2024

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28724

Paper Vaccine process technology—A decade of progress

Barry Buckland; Gautam Sanyal; Todd Ranheim et al. · 2024 · Biotechnology and Bioengineering · DOI

Full title: Vaccine process technology—A decade of progress

Authors: Barry Buckland; Gautam Sanyal; Todd Ranheim; David Pollard; J. Searles; Sue Behrens; Stefanie Pluschkell; Jessica O. Josefsberg; Christopher J Roberts

Year: 2024

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28703

Paper An adaptive soft-sensor for advanced real-time monitoring of an antibody-drug conjugation reaction.

Schiemer, Robin; Weggen, Jan Tobias; Schmitt, Katrin Marianne et al. · 2023 · Biotechnology and bioengineering · DOI

Full title: An adaptive soft-sensor for advanced real-time monitoring of an antibody-drug conjugation reaction.

Authors: Schiemer, Robin; Weggen, Jan Tobias; Schmitt, Katrin Marianne; Hubbuch, Jürgen

Year: 2023

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28428

Paper NIR spectroscopy—CNN‐enabled chemometrics for multianalyte monitoring in microbial fermentation

Banerjee, Shantanu; Mandal, Shyamapada; Jesubalan, Naveen G. et al. · 2024 · Biotechnology and Bioengineering · DOI

Full title: NIR spectroscopy—CNN‐enabled chemometrics for multianalyte monitoring in microbial fermentation

Authors: Banerjee, Shantanu; Mandal, Shyamapada; Jesubalan, Naveen G.; Jain, Rijul; Rathore, Anurag S.

Year: 2024

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28681

Paper Predictive modeling for cell culture in commercial manufacturing of biotherapeutics

Panjwani, Shyam; Almazan, Alice; Hille, Rubin et al. · 2024 · Biotechnology and Bioengineering · DOI

Full title: Predictive modeling for cell culture in commercial manufacturing of biotherapeutics

Authors: Panjwani, Shyam; Almazan, Alice; Hille, Rubin; Spetsieris, Konstantinos

Year: 2024

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28813

Paper Implementation of Innovative Process Analytical Technologies to Characterize Critical Quality Attributes of Co-Formulated Monoclonal Antibody Products.

Godbole, Apurva; Chen, Lyufei; Desai, Jay et al. · 2025 · Biotechnology and bioengineering · DOI

Full title: Implementation of Innovative Process Analytical Technologies to Characterize Critical Quality Attributes of Co-Formulated Monoclonal Antibody Products.

Authors: Godbole, Apurva; Chen, Lyufei; Desai, Jay; Raghava, Smita; Ruzanski, Richard; Patel, Bhumit; Appiah-Amponsah, Emmanuel; Feng, Hanzhou

Year: 2025

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28881

Paper Temporal Galactose‐Manganese Feeding in Fed‐Batch and Perfusion Bioreactors Modulates UDP‐Galactose Pools for Enhanced mAb Glycosylation Homogeneity

Aron Gyorgypal; Erica J. Fratz-Berilla; Casey Kohnhorst et al. · 2025 · Biotechnology and Bioengineering · DOI

Full title: Temporal Galactose‐Manganese Feeding in Fed‐Batch and Perfusion Bioreactors Modulates UDP‐Galactose Pools for Enhanced mAb Glycosylation Homogeneity

Authors: Aron Gyorgypal; Erica J. Fratz-Berilla; Casey Kohnhorst; David N. Powers; S. Chundawat

Year: 2025

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28999

Paper Defining Golden Batches in Biomanufacturing Processes From Internal Metabolic Activity to Detect Process Changes That May Affect Product Quality

Bush, Xin; Fratz‐Berilla, Erica J.; Kohnhorst, Casey et al. · 2024 · Biotechnology and Bioengineering · DOI

Full title: Defining Golden Batches in Biomanufacturing Processes From Internal Metabolic Activity to Detect Process Changes That May Affect Product Quality

Authors: Bush, Xin; Fratz‐Berilla, Erica J.; Kohnhorst, Casey; King, Robert J.; Agarabi, Cyrus; Powers, David N.; Trunfio, Nicholas

Year: 2024

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28873

Paper Development of Raman Spectroscopy and Machine Learning Methods for Protein Aggregate Quantification: Application to BSA in Chromatographic Processes

Heyer‐Müller, Jakob; Schiemer, Robin; Robbel, Lars et al. · 2026 · Biotechnology and Bioengineering · DOI

Full title: Development of Raman Spectroscopy and Machine Learning Methods for Protein Aggregate Quantification: Application to BSA in Chromatographic Processes

Authors: Heyer‐Müller, Jakob; Schiemer, Robin; Robbel, Lars; Schmitt, Michael; Hubbuch, Jürgen

Year: 2026

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.70163

Paper A Setup for Automatic Raman Measurements in High‐Throughput Experimentation

Lange, Catherine; Seidel, Simon; Altmann, Margaret et al. · 2025 · Biotechnology and Bioengineering · DOI

Full title: A Setup for Automatic Raman Measurements in High‐Throughput Experimentation

Authors: Lange, Catherine; Seidel, Simon; Altmann, Margaret; Stors, Daniel; Kemmer, Annina; Cai, Linda; Born, Stefan; Neubauer, Peter; Bournazou, Mariano Nicolás Cruz

Year: 2025

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.70006

Paper Towards Rapid Calibration of Bioprocess Quantification Models Using Single Compound Raman Spectra: A Comparison of Four Approaches.

Klaverdijk, Maarten; Smulders, Lisa A; Ottens, Marcel et al. · 2026 · Biotechnology and bioengineering · DOI

Full title: Towards Rapid Calibration of Bioprocess Quantification Models Using Single Compound Raman Spectra: A Comparison of Four Approaches.

Authors: Klaverdijk, Maarten; Smulders, Lisa A; Ottens, Marcel; Klijn, Marieke E

Year: 2026

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.70092

Paper On‐line targeted metabolomics for real‐time monitoring of relevant compounds in fermentation processes

Cortada‐Garcia, Joan; Haggarty, Jennifer; Weidt, Stefan et al. · 2023 · Biotechnology and Bioengineering · DOI

Full title: On‐line targeted metabolomics for real‐time monitoring of relevant compounds in fermentation processes

Authors: Cortada‐Garcia, Joan; Haggarty, Jennifer; Weidt, Stefan; Daly, Rónán; Arnold, S. Alison; Burgess, Karl

Year: 2023

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28599

Paper Less Is More: Practical Insights Into Multivariate Regression Models for Raman Spectroscopy in Bioprocess Monitoring

Borg, Åke; Elhabiri, Mourad; Calvé, Stéphane Le et al. · 2025 · Biotechnology and Bioengineering · DOI

Full title: Less Is More: Practical Insights Into Multivariate Regression Models for Raman Spectroscopy in Bioprocess Monitoring

Authors: Borg, Åke; Elhabiri, Mourad; Calvé, Stéphane Le; Portaluri, Vincent

Year: 2025

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.70118

Paper Characterization of mammalian cell culture raw materials by combining spectroscopy and chemometrics

Trunfio, Nicholas; Lee, Haewoo; Starkey, Jason A. et al. · 2017 · Biotechnology Progress · DOI

Full title: Characterization of mammalian cell culture raw materials by combining spectroscopy and chemometrics

Authors: Trunfio, Nicholas; Lee, Haewoo; Starkey, Jason A.; Agarabi, Cyrus; Liu, Jay; Yoon, Seongkyu

Year: 2017

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2480

Paper Glucose monitoring and adaptive feeding of mammalian cell culture in the presence of strong autofluorescence by near infrared Raman spectroscopy.

Matthews, Thomas E; Smelko, John P; Berry, Brandon et al. · 2018 · Biotechnology progress · DOI

Full title: Glucose monitoring and adaptive feeding of mammalian cell culture in the presence of strong autofluorescence by near infrared Raman spectroscopy.

Authors: Matthews, Thomas E; Smelko, John P; Berry, Brandon; Romero-Torres, Saly; Hill, Dan; Kshirsagar, Rashmi; Wiltberger, Kelly

Year: 2018

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2711

Paper Raman based chemometric model development for glycation and glycosylation real time monitoring in a manufacturing scale CHO cell bioreactor process.

A Gibbons, Luke; Rafferty, Carl; Robinson, Kerry et al. · 2022 · Biotechnology progress · DOI

Full title: Raman based chemometric model development for glycation and glycosylation real time monitoring in a manufacturing scale CHO cell bioreactor process.

Authors: A Gibbons, Luke; Rafferty, Carl; Robinson, Kerry; Abad, Marta; Maslanka, Francis; Le, Nikky; Mo, Jingjie; Clark, Kevin; Madden, Fiona; Hayes, Ronan; McCarthy, Barry; Rode, Christopher; O'Mahony, Jim; Rea, Rosemary; O'Mahony Hartnett, Caitlin

Year: 2022

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3223

Paper Multivariate data analysis on multisensor measurement for inline process monitoring of adenovirus production in HEK293 cells.

Xu, Xingge; Farnós, Omar; Paes, Barbara C M F et al. · 2024 · Biotechnology and bioengineering · DOI

Full title: Multivariate data analysis on multisensor measurement for inline process monitoring of adenovirus production in HEK293 cells.

Authors: Xu, Xingge; Farnós, Omar; Paes, Barbara C M F; Nesdoly, Sean; Kamen, Amine A

Year: 2024

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28712

Paper Comparison of spectroscopy technologies for improved monitoring of cell culture processes in miniature bioreactors

Rowland‐Jones, Ruth C.; Berg, Frans van den; Racher, Andrew J. et al. · 2017 · Biotechnology Progress · DOI

Full title: Comparison of spectroscopy technologies for improved monitoring of cell culture processes in miniature bioreactors

Authors: Rowland‐Jones, Ruth C.; Berg, Frans van den; Racher, Andrew J.; Martin, Elaine; Jaques, Colin

Year: 2017

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2459

Paper Interest of locally weighted regression to overcome nonlinear effects during in situ NIR monitoring of CHO cell culture parameters and antibody glycosylation

Zavala-Ortiz, Daniel; Ebel, Bruno; Li, Mengyao et al. · 2019 · Biotechnology Progress · DOI

Full title: Interest of locally weighted regression to overcome nonlinear effects during in situ NIR monitoring of CHO cell culture parameters and antibody glycosylation

Authors: Zavala-Ortiz, Daniel; Ebel, Bruno; Li, Mengyao; Barradas-Dermitz, Dulce; Hayward‐Jones, Patricia M.; Aguilar‐Uscanga, María Guadalupe; Marc, Annie; Guédon, Emmanuel

Year: 2019

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2924

Paper Inline noninvasive Raman monitoring and feedback control of glucose concentration during ethanol fermentation

Hirsch, Edit; Pataki, Hajnalka; Domján, Júlia et al. · 2019 · Biotechnology Progress · DOI

Full title: Inline noninvasive Raman monitoring and feedback control of glucose concentration during ethanol fermentation

Authors: Hirsch, Edit; Pataki, Hajnalka; Domján, Júlia; Farkas, Attila; Vass, Panna; Fehér, Csaba; Barta, Zsolt; Nagy, Zsombor Kristóf; Marosi, György; Csontos, István

Year: 2019

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2848

Paper An assessment of the impact of Raman based glucose feedback control on CHO cell bioreactor process development.

Gibbons, Luke; Maslanka, Francis; Le, Nikky et al. · 2023 · Biotechnology progress · DOI

Full title: An assessment of the impact of Raman based glucose feedback control on CHO cell bioreactor process development.

Authors: Gibbons, Luke; Maslanka, Francis; Le, Nikky; Magill, Al; Singh, Pankaj; Mclaughlin, Joseph; Madden, Fiona; Hayes, Ronan; McCarthy, Barry; Rode, Christopher; O'Mahony, Jim; Rea, Rosemary; O'Mahony-Hartnett, Caitlin

Year: 2023

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3371

Paper Micro sequential injection system as the interfacing device for process analytical applications.

Wu, Chao-Hsiang Richard; Wee, Siowfong · 2015 · Biotechnology progress · DOI

Full title: Micro sequential injection system as the interfacing device for process analytical applications.

Authors: Wu, Chao-Hsiang Richard; Wee, Siowfong

Year: 2015

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2055

Paper Tuning monoclonal antibody galactosylation using Raman spectroscopy-controlled lactic acid feeding.

W Eyster, Thomas; Talwar, Sameer; Fernandez, Janice et al. · 2021 · Biotechnology progress · DOI

Full title: Tuning monoclonal antibody galactosylation using Raman spectroscopy-controlled lactic acid feeding.

Authors: W Eyster, Thomas; Talwar, Sameer; Fernandez, Janice; Foster, Shelby; Hayes, James; Allen, Randal; Reidinger, Scot; Wan, Boyong; Ji, Xiaodan; Aon, Juan; Patel, Pramthesh; Ritz, Diana B

Year: 2021

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3085

Paper Monitoring mAb cultivations with in-situ raman spectroscopy: The influence of spectral selectivity on calibration models and industrial use as reliable PAT tool.

Santos, Rafael M; Kessler, Jean-Michel; Salou, Patrick et al. · 2018 · Biotechnology progress · DOI

Full title: Monitoring mAb cultivations with in-situ raman spectroscopy: The influence of spectral selectivity on calibration models and industrial use as reliable PAT tool.

Authors: Santos, Rafael M; Kessler, Jean-Michel; Salou, Patrick; Menezes, Jose C; Peinado, Antonio

Year: 2018

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2635

Paper Raw material quality assessment approaches comparison in pectin production

Caroço, Ricardo F.; Bevilacqua, Marta; Armagan, Ibrahim et al. · 2018 · Biotechnology Progress · DOI

Full title: Raw material quality assessment approaches comparison in pectin production

Authors: Caroço, Ricardo F.; Bevilacqua, Marta; Armagan, Ibrahim; Santacoloma, Paloma A.; Abildskov, Jens; Skov, Thomas; Huusom, Jakob Kjøbsted

Year: 2018

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2762

Paper Comparison of time‐gated surface‐enhanced raman spectroscopy (TG‐SERS) and classical SERS based monitoring of Escherichia coli cultivation samples

Kögler, Martin; Paul, Andrea; Anane, Emmanuel et al. · 2018 · Biotechnology Progress · DOI

Full title: Comparison of time‐gated surface‐enhanced raman spectroscopy (TG‐SERS) and classical SERS based monitoring of Escherichia coli cultivation samples

Authors: Kögler, Martin; Paul, Andrea; Anane, Emmanuel; Birkholz, M.; Bunker, Alex; Viitala, Tapani; Maiwald, Michael; Junne, Stefan; Neubauer, Peter

Year: 2018

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2665

Paper Rapid total sialic acid monitoring during cell culture process using a machine learning model based soft sensor.

Behdani, Amir M; Zhao, Yuxiang; Yao, Grace et al. · 2024 · Biotechnology progress · DOI

Full title: Rapid total sialic acid monitoring during cell culture process using a machine learning model based soft sensor.

Authors: Behdani, Amir M; Zhao, Yuxiang; Yao, Grace; Wasalathanthri, Dhanuka; Hodgman, Eric; Borys, Michael; Li, Gloria; Khetan, Anurag; Wijesinghe, Dayanjan; Leone, Anthony

Year: 2024

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3493

Paper Minimizing batch-to-batch variability of a live virus vaccine by process analytical technologies.

Forrester, Katherine; Blanda, Thomas R; Trauger, Marena et al. · 2025 · Biotechnology progress · DOI

Full title: Minimizing batch-to-batch variability of a live virus vaccine by process analytical technologies.

Authors: Forrester, Katherine; Blanda, Thomas R; Trauger, Marena; Thompson, Rachel; Templeton, Neil

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.70037

Paper Innovative methodology for flexible monitoring of various bioprocesses by using pre-existing Raman data coupled with automated transfer learning technique.

Schini, Adèle; El Radi, Hadi; Cailletaud, Johan et al. · 2026 · Biotechnology progress · DOI

Full title: Innovative methodology for flexible monitoring of various bioprocesses by using pre-existing Raman data coupled with automated transfer learning technique.

Authors: Schini, Adèle; El Radi, Hadi; Cailletaud, Johan; Sanchez, Célia; Gay, Nathan; Ebel, Bruno; Guedon, Emmanuel; Jourdainne, Laurent

Year: 2026

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.70111

Paper Application of a fluorescent dye‐based microfluidic sensor for real‐time detection of mAb aggregates

Mariana N São Pedro; M. Eppink; M. Ottens · 2023 · Biotechnology progress (Print) · DOI

Full title: Application of a fluorescent dye‐based microfluidic sensor for real‐time detection of mAb aggregates

Authors: Mariana N São Pedro; M. Eppink; M. Ottens

Year: 2023

Venue: Biotechnology progress (Print)

DOI: https://doi.org/10.1002/btpr.3355

Paper Real time on‐line amino acid analysis to explore amino acid trends and link to glycosylation outcomes of a model monoclonal antibody

Azer, Nicole; Trunfio, Nicholas; Fratz‐Berilla, Erica J. et al. · 2023 · Biotechnology Progress · DOI

Full title: Real time on‐line amino acid analysis to explore amino acid trends and link to glycosylation outcomes of a model monoclonal antibody

Authors: Azer, Nicole; Trunfio, Nicholas; Fratz‐Berilla, Erica J.; Hong, Jin Sung; Cullinan, Jackie; Faison, Talia; Agarabi, Cyrus; Powers, David N.

Year: 2023

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.3347

Paper An adaptive modeling approach using spiking‐augmentation method to improve chemometric model performance in bioprocess monitoring

Zhao, Yuxiang; Tang, Yawen; Wasalathanthri, Dhanuka P. et al. · 2023 · Biotechnology Progress · DOI

Full title: An adaptive modeling approach using spiking‐augmentation method to improve chemometric model performance in bioprocess monitoring

Authors: Zhao, Yuxiang; Tang, Yawen; Wasalathanthri, Dhanuka P.; Xu, Jianlin; Ding, Julia

Year: 2023

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.3349

Paper Near-infrared spectroscopy coupled with convolutional neural network as a checkpoint tool for cell culture bioprocess media characterization.

Gangwar, Neelesh; Balraj, Keerthiveena; Rathore, Anurag S · 2025 · Biotechnology progress · DOI

Full title: Near-infrared spectroscopy coupled with convolutional neural network as a checkpoint tool for cell culture bioprocess media characterization.

Authors: Gangwar, Neelesh; Balraj, Keerthiveena; Rathore, Anurag S

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.70056

Paper Cell Culture Media and Raman Spectra Preprocessing Procedures Impact Glucose Chemometrics

Pavurala, Naresh; Madhavarao, Chikkathur N.; Lee, Jaeweon et al. · 2025 · Journal of Chemometrics · DOI

Full title: Cell Culture Media and Raman Spectra Preprocessing Procedures Impact Glucose Chemometrics

Authors: Pavurala, Naresh; Madhavarao, Chikkathur N.; Lee, Jaeweon; Das, Jayanti; Ashraf, Muhammad; O’Connor, Thomas

Year: 2025

Venue: Journal of Chemometrics

DOI: https://doi.org/10.1002/cem.70005

Paper Exploring the potential of machine learning for more efficient development and production of biopharmaceuticals.

Puranik, Amita; Dandekar, Prajakta; Jain, Ratnesh · 2022 · Biotechnology progress · DOI

Full title: Exploring the potential of machine learning for more efficient development and production of biopharmaceuticals.

Authors: Puranik, Amita; Dandekar, Prajakta; Jain, Ratnesh

Year: 2022

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3291

Paper A recurrent neural network for soft sensor development using CHO stable pools in fed‐batch process for SARS ‐ CoV ‐2 spike protein production as a vaccine antigen

Reyes, Sebastian‐Juan; Voyer, Robert; Durocher, Yves et al. · 2025 · Biotechnology Progress · DOI

Full title: A recurrent neural network for soft sensor development using CHO stable pools in fed‐batch process for SARS ‐ CoV ‐2 spike protein production as a vaccine antigen

Authors: Reyes, Sebastian‐Juan; Voyer, Robert; Durocher, Yves; Henry, Olivier; Pham, Phuong Lan

Year: 2025

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.70046

Paper Sensors for disposable bioreactors

Busse, Christoph; Biechele, P.; Vries, Ingo de et al. · 2017 · Engineering in Life Sciences · DOI

Full title: Sensors for disposable bioreactors

Authors: Busse, Christoph; Biechele, P.; Vries, Ingo de; Reardon, Kenneth F.; Solle, Dörte; Scheper, Thomas

Year: 2017

Venue: Engineering in Life Sciences

DOI: https://doi.org/10.1002/elsc.201700049

Paper Novel approach for the prediction of cell densities and viability in standardized translucent cell culture biochips with near infrared spectroscopy

Gröger, Marko; Lange, Matthias; Rennert, Knut et al. · 2016 · Engineering in Life Sciences · DOI

Full title: Novel approach for the prediction of cell densities and viability in standardized translucent cell culture biochips with near infrared spectroscopy

Authors: Gröger, Marko; Lange, Matthias; Rennert, Knut; Kaschowitz, Tobias; Plettenberg, Holger; Hoffmann, Martin; Mosig, Alexander S.

Year: 2016

Venue: Engineering in Life Sciences

DOI: https://doi.org/10.1002/elsc.201600162

Paper Progress of Complex System Process Analysis Based on Modern Spectroscopy Combined With Chemometrics

Li, Maogang; Cai, Qi; Zhang, Tianlong et al. · 2025 · Journal of Chemometrics · DOI

Full title: Progress of Complex System Process Analysis Based on Modern Spectroscopy Combined With Chemometrics

Authors: Li, Maogang; Cai, Qi; Zhang, Tianlong; Tang, Hongsheng; Li, Hua

Year: 2025

Venue: Journal of Chemometrics

DOI: https://doi.org/10.1002/cem.70006

Paper A novel LED‐based 2D‐fluorescence spectroscopy system for in‐line bioprocess monitoring of Chinese hamster ovary cell cultivations—Part II

Claßen, Jens; Graf, Alexander; Aupert, Florian et al. · 2019 · Engineering in Life Sciences · DOI

Full title: A novel LED‐based 2D‐fluorescence spectroscopy system for in‐line bioprocess monitoring of Chinese hamster ovary cell cultivations—Part II

Authors: Claßen, Jens; Graf, Alexander; Aupert, Florian; Solle, Dörte; Höhse, Marek; Scheper, Thomas

Year: 2019

Venue: Engineering in Life Sciences

DOI: https://doi.org/10.1002/elsc.201800146

Paper Lean Chemometrics in Spectroscopic Process Analytical Technology

Rish, Adam J.; Henson, Samuel R.; Rehrauer, Owen G. · 2026 · Journal of Chemometrics · DOI

Full title: Lean Chemometrics in Spectroscopic Process Analytical Technology

Authors: Rish, Adam J.; Henson, Samuel R.; Rehrauer, Owen G.

Year: 2026

Venue: Journal of Chemometrics

DOI: https://doi.org/10.1002/cem.70105

Paper Advanced monitoring and control of pharmaceutical production processes with Pichia pastoris by using Raman spectroscopy and multivariate calibration methods

Voss, Jan‐Patrick; Mittelheuser, Nina E.; Lemke, Roman et al. · 2017 · Engineering in Life Sciences · DOI

Full title: Advanced monitoring and control of pharmaceutical production processes with Pichia pastoris by using Raman spectroscopy and multivariate calibration methods

Authors: Voss, Jan‐Patrick; Mittelheuser, Nina E.; Lemke, Roman; Luttmann, R.

Year: 2017

Venue: Engineering in Life Sciences

DOI: https://doi.org/10.1002/elsc.201600229

Paper Continuous glucose feedback control using Raman spectroscopy and deep learning models for biopharmaceutical processes.

Rashedi, Mohammad; Demers, Matthew; Khodabandehlou, Hamid et al. · 2025 · Biotechnology progress · DOI

Full title: Continuous glucose feedback control using Raman spectroscopy and deep learning models for biopharmaceutical processes.

Authors: Rashedi, Mohammad; Demers, Matthew; Khodabandehlou, Hamid; Wang, Tony; Garvin, Christopher; Rianna, Steve

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.70020

Paper Enabler for process analytical technology implementation in Pichia pastoris fermentation: Fluorescence-based soft sensors for rapid quantitation of product titer.

Chopda, Viki R; Pathak, Mili; Batra, Jyoti et al. · 2017 · Engineering in life sciences · DOI

Full title: Enabler for process analytical technology implementation in Pichia pastoris fermentation: Fluorescence-based soft sensors for rapid quantitation of product titer.

Authors: Chopda, Viki R; Pathak, Mili; Batra, Jyoti; Gomes, James; Rathore, Anurag S

Year: 2017

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.201600155

Paper In-line monitoring of protein concentration with MIR spectroscopy during UFDF.

Milewska, Adrianna; Baekelandt, Géraldine; Boutaieb, Sarra et al. · 2023 · Engineering in life sciences · DOI

Full title: In-line monitoring of protein concentration with MIR spectroscopy during UFDF.

Authors: Milewska, Adrianna; Baekelandt, Géraldine; Boutaieb, Sarra; Mozin, Vitalii; Falconbridge, Andrew

Year: 2023

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.202200050

Paper Soft sensor based on 2D-fluorescence and process data enabling real-time estimation of biomass in Escherichia coli cultivations.

Bayer, Benjamin; von Stosch, Moritz; Melcher, Michael et al. · 2020 · Engineering in life sciences · DOI

Full title: Soft sensor based on 2D-fluorescence and process data enabling real-time estimation of biomass in Escherichia coli cultivations.

Authors: Bayer, Benjamin; von Stosch, Moritz; Melcher, Michael; Duerkop, Mark; Striedner, Gerald

Year: 2020

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.201900076

Paper Real-Time VCC Monitoring and Forecasting in HEK-Cell-Based rAAV Vector Production Using Capacitance Spectroscopy.

Machleid, Rafael; Nunna, Suneetha; George, Ajith et al. · 2025 · Engineering in life sciences · DOI

Full title: Real-Time VCC Monitoring and Forecasting in HEK-Cell-Based rAAV Vector Production Using Capacitance Spectroscopy.

Authors: Machleid, Rafael; Nunna, Suneetha; George, Ajith; Austerjost, Jonas; Tomala, Magda; Surowiec, Izabella

Year: 2025

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.70004

Paper Optimization of a mAb production process with regard to robustness and product quality using quality by design principles.

Wohlenberg, Ole Jacob; Kortmann, Carlotta; Meyer, Katharina V et al. · 2022 · Engineering in life sciences · DOI

Full title: Optimization of a mAb production process with regard to robustness and product quality using quality by design principles.

Authors: Wohlenberg, Ole Jacob; Kortmann, Carlotta; Meyer, Katharina V; Schellenberg, Jana; Dahlmann, Katharina; Bahnemann, Janina; Scheper, Thomas; Solle, Dörte

Year: 2022

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.202100172

Paper Raman‐Enabled Predictions of Protein Content and Metabolites in Biopharmaceutical Saccharomyces cerevisiae Fermentations

Hagedorn, Jeppe; Ramos, Guilherme Piovezani; Ressurreição, Miguel et al. · 2024 · Engineering in Life Sciences · DOI

Full title: Raman‐Enabled Predictions of Protein Content and Metabolites in Biopharmaceutical Saccharomyces cerevisiae Fermentations

Authors: Hagedorn, Jeppe; Ramos, Guilherme Piovezani; Ressurreição, Miguel; Hansen, Ernst Broberg; Sokolov, Michael; Vázquez, Carlos; Panos, Charles

Year: 2024

Venue: Engineering in Life Sciences

DOI: https://doi.org/10.1002/elsc.202400045

Paper A Novel Raman-Chromatography Assembly for Automated Calibration and In-Line Monitoring in Bioprocessing.

Heyer-Müller, Jakob; Schiemer, Robin; Lopinski, Matthias et al. · 2025 · Engineering in life sciences · DOI

Full title: A Novel Raman-Chromatography Assembly for Automated Calibration and In-Line Monitoring in Bioprocessing.

Authors: Heyer-Müller, Jakob; Schiemer, Robin; Lopinski, Matthias; Wang, Caty; Willems, Franka; Robbel, Lars; Schmitt, Michael; Hubbuch, Jurgen

Year: 2025

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.70044

Paper Towards robust cell culture processes — Unraveling the impact of media preparation by spectroscopic online monitoring

Brunner, Matthias; Brosig, Philipp; Losing, Monika et al. · 2019 · Engineering in Life Sciences · DOI

Full title: Towards robust cell culture processes — Unraveling the impact of media preparation by spectroscopic online monitoring

Authors: Brunner, Matthias; Brosig, Philipp; Losing, Monika; Kunzelmann, Marco; Calvet, Amandine; Stiefel, Fabian; Bechmann, Jan; Unsoeld, Andreas; Schaub, Jochen

Year: 2019

Venue: Engineering in Life Sciences

DOI: https://doi.org/10.1002/elsc.201900050

Paper Automized inline monitoring in perfused mammalian cell culture by MIR spectroscopy without calibration model building

Hannah Marienberg; Nicole Desch; Vitalii Mozin et al. · 2023 · Engineering in Life Sciences · DOI

Full title: Automized inline monitoring in perfused mammalian cell culture by MIR spectroscopy without calibration model building

Authors: Hannah Marienberg; Nicole Desch; Vitalii Mozin; Lorenz Sykora‐Mirle; Anja Müller; Andreas Roth; Mathias Käfer; Rüdiger Neef

Year: 2023

Venue: Engineering in Life Sciences

DOI: https://doi.org/10.1002/elsc.202300237

Paper Integrated SegFlow, µSIA, and UPLC for Online Sialic Acid Quantitation of Glycoproteins Directly from Bioreactors

Letha Chemmalil; T. Kulkarni; Mathura Raman et al. · 2025 · Engineering in Life Sciences · DOI

Full title: Integrated SegFlow, µSIA, and UPLC for Online Sialic Acid Quantitation of Glycoproteins Directly from Bioreactors

Authors: Letha Chemmalil; T. Kulkarni; Mathura Raman; Priya Singh; Yueming Qian; Chris Chumsae; Kyle P. McHugh; Zhuangrong Huang; Eric Hodgman; Michael C. Borys; Julia Ding; Gloria Li; Anthony Leone

Year: 2025

Venue: Engineering in Life Sciences

DOI: https://doi.org/10.1002/elsc.202400031

Paper In‐line monitoring of amino acids in mammalian cell cultures using raman spectroscopy and multivariate chemometrics models

Bhatia, Hemlata; Mehdizadeh, Hamidreza; Drapeau, Denis et al. · 2017 · Engineering in Life Sciences · DOI

Full title: In‐line monitoring of amino acids in mammalian cell cultures using raman spectroscopy and multivariate chemometrics models

Authors: Bhatia, Hemlata; Mehdizadeh, Hamidreza; Drapeau, Denis; Yoon, Seongkyu

Year: 2017

Venue: Engineering in Life Sciences

DOI: https://doi.org/10.1002/elsc.201700084

Paper Process analytical technique ( PAT ) miniaturization for monoclonal antibody aggregate detection in continuous downstream processing

Pedro, Mariana N. São; Klijn, Marieke E.; Eppink, Michel H. M. et al. · 2021 · Journal of Chemical Technology & Biotechnology · DOI

Full title: Process analytical technique ( PAT ) miniaturization for monoclonal antibody aggregate detection in continuous downstream processing

Authors: Pedro, Mariana N. São; Klijn, Marieke E.; Eppink, Michel H. M.; Ottens, Marcel

Year: 2021

Venue: Journal of Chemical Technology & Biotechnology

DOI: https://doi.org/10.1002/jctb.6920

Paper Raman Spectroscopy as a Tool for Real‐Time Nutrient Monitoring in Bioreactor Cultivation of Microalgae

Karnachoriti, Maria; Chatzipetrou, Marianneza; Touloupakis, Eleftherios et al. · 2025 · Journal of Raman Spectroscopy · DOI

Full title: Raman Spectroscopy as a Tool for Real‐Time Nutrient Monitoring in Bioreactor Cultivation of Microalgae

Authors: Karnachoriti, Maria; Chatzipetrou, Marianneza; Touloupakis, Eleftherios; Kontos, Athanassios G.; Zergioti, I.

Year: 2025

Venue: Journal of Raman Spectroscopy

DOI: https://doi.org/10.1002/jrs.6841

Paper Prediction of intensified ethanol fermentation of sugarcane using a deep learning soft sensor and process analytical technology

Elmer C Rivera; C. K. Yamakawa; C. Rossell et al. · 2023 · Journal of Chemical Technology & Biotechnology · DOI

Full title: Prediction of intensified ethanol fermentation of sugarcane using a deep learning soft sensor and process analytical technology

Authors: Elmer C Rivera; C. K. Yamakawa; C. Rossell; Jonas Nolasco; Hyun J. Kwon

Year: 2023

Venue: Journal of Chemical Technology & Biotechnology

DOI: https://doi.org/10.1002/jctb.7525

Paper Introducing diffusing wave spectroscopy as a process analytical tool for pharmaceutical emulsion manufacturing.

Reufer, Mathias; Machado, Alexandra H E; Niederquell, Andreas et al. · 2014 · Journal of pharmaceutical sciences · DOI

Full title: Introducing diffusing wave spectroscopy as a process analytical tool for pharmaceutical emulsion manufacturing.

Authors: Reufer, Mathias; Machado, Alexandra H E; Niederquell, Andreas; Bohnenblust, Katharina; Müller, Beat; Völker, Andreas Charles; Kuentz, Martin

Year: 2014

Venue: Journal of pharmaceutical sciences

DOI: https://doi.org/10.1002/jps.24197

Paper Calibration transfer for bioprocess Raman monitoring using Kennard Stone piecewise direct standardization and multivariate algorithms

Pétillot, Laure; Pewny, Fiona; Wolf, Martin et al. · 2020 · Engineering Reports · DOI

Full title: Calibration transfer for bioprocess Raman monitoring using Kennard Stone piecewise direct standardization and multivariate algorithms

Authors: Pétillot, Laure; Pewny, Fiona; Wolf, Martin; Sanchez, Célia; Thomas, Fabrice; Sarrazin, Johan; Fauland, Katharina; Katinger, Hermann; Javalet, Charlotte; Bonneville, Christophe

Year: 2020

Venue: Engineering Reports

DOI: https://doi.org/10.1002/eng2.12230

Paper Feasibility assessment of a low‐cost near‐infrared spectroscopy‐based prototype for monitoring polyphenol extraction in fermenting musts

Alfieri, Gianmarco; Riggi, Riccardo; Modesti, Margherita et al. · 2025 · Journal of the Science of Food and Agriculture · DOI

Full title: Feasibility assessment of a low‐cost near‐infrared spectroscopy‐based prototype for monitoring polyphenol extraction in fermenting musts

Authors: Alfieri, Gianmarco; Riggi, Riccardo; Modesti, Margherita; Bellincontro, Andrea; Renzi, Francesco; Aleixandre-Tudó, José Luis

Year: 2025

Venue: Journal of the Science of Food and Agriculture

DOI: https://doi.org/10.1002/jsfa.14321

Paper Sustainability impacts for converting to Raman spectroscopy inline monitoring from traditional offline manual sampling in small‐scale and large‐scale biomanufacturing

S. Simon; Phyllis Pugh; Preeya Boppana et al. · 2025 · Journal of Chemical Technology & Biotechnology · DOI

Full title: Sustainability impacts for converting to Raman spectroscopy inline monitoring from traditional offline manual sampling in small‐scale and large‐scale biomanufacturing

Authors: S. Simon; Phyllis Pugh; Preeya Boppana; Zahra Allen; Jenna Lemons; Veera Padmanabhan

Year: 2025

Venue: Journal of Chemical Technology & Biotechnology

DOI: https://doi.org/10.1002/jctb.70084

Paper Uncertainty Quantification Using Ensemble Learning and Monte Carlo Sampling for Performance Prediction and Monitoring in Cell Culture Processes

Khuat, Thanh Tung; Bassett, Robert; Otte, Ellen et al. · 2025 · Journal of Raman Spectroscopy · DOI

Full title: Uncertainty Quantification Using Ensemble Learning and Monte Carlo Sampling for Performance Prediction and Monitoring in Cell Culture Processes

Authors: Khuat, Thanh Tung; Bassett, Robert; Otte, Ellen; Gabryś, Bogdan

Year: 2025

Venue: Journal of Raman Spectroscopy

DOI: https://doi.org/10.1002/jrs.6808

Paper ATR-FTIR sensor development for continuous on-line monitoring of chlorinated aliphatic hydrocarbons in a fixed-bed bioreactor

Acha, Victor; Meurens, Marc; Naveau, Henry et al. · 2000 · Biotechnology and Bioengineering · DOI

Full title: ATR-FTIR sensor development for continuous on-line monitoring of chlorinated aliphatic hydrocarbons in a fixed-bed bioreactor

Authors: Acha, Victor; Meurens, Marc; Naveau, Henry; Agathos, Spiros N.

Year: 2000

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/(sici)1097-0290(20000605)68:5<473::aid-bit1>3.0.co;2-8

Paper Process Analytical Technologies in Biopharmaceutical Process Development

Rathore, Anurag S.; Gernaey, Krist V.; Calado, Cecília R. C. et al. · 2015 · Journal of Chemical Technology & Biotechnology · DOI

Full title: Process Analytical Technologies in Biopharmaceutical Process Development

Authors: Rathore, Anurag S.; Gernaey, Krist V.; Calado, Cecília R. C.; Yoon, Seongkyu

Year: 2015

Venue: Journal of Chemical Technology & Biotechnology

DOI: https://doi.org/10.1002/jctb.4614

Paper Batch Statistical Process Monitoring Approach to a Cocrystallization Process.

Sarraguça, Mafalda C; Ribeiro, Paulo R S; Dos Santos, Adenilson O et al. · 2015 · Journal of pharmaceutical sciences · DOI

Full title: Batch Statistical Process Monitoring Approach to a Cocrystallization Process.

Authors: Sarraguça, Mafalda C; Ribeiro, Paulo R S; Dos Santos, Adenilson O; Lopes, João A

Year: 2015

Venue: Journal of pharmaceutical sciences

DOI: https://doi.org/10.1002/jps.24623

Paper Turbidimetry and Dielectric Spectroscopy as Process Analytical Technologies for Mammalian and Insect Cell Cultures.

Käßer, Lukas; Zitzmann, Jan; Grein, Tanja et al. · 2020 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Turbidimetry and Dielectric Spectroscopy as Process Analytical Technologies for Mammalian and Insect Cell Cultures.

Authors: Käßer, Lukas; Zitzmann, Jan; Grein, Tanja; Weidner, Tobias; Salzig, Denise; Czermak, Peter

Year: 2020

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-0716-0191-4_20

Paper Multi‐dimensional technology – Recent advances and applications for biotherapeutic characterization

Bouvarel, Thomas; Camperi, Julien; Guillarme, Davy · 2024 · Journal of Separation Science · DOI

Full title: Multi‐dimensional technology – Recent advances and applications for biotherapeutic characterization

Authors: Bouvarel, Thomas; Camperi, Julien; Guillarme, Davy

Year: 2024

Venue: Journal of Separation Science

DOI: https://doi.org/10.1002/jssc.202300928

Paper Cavity‐Like Silver Aggregates‐Based Colloidal SERS Microfluidic Platform for Highly Reproducible Online Reaction Process Analysis

Yan, Shuoyang; Zhang, Zhiyang; Chen, Jiadong et al. · 2025 · Small · DOI

Full title: Cavity‐Like Silver Aggregates‐Based Colloidal SERS Microfluidic Platform for Highly Reproducible Online Reaction Process Analysis

Authors: Yan, Shuoyang; Zhang, Zhiyang; Chen, Jiadong; Wang, Qiaoning; Wu, Yanzhou; Sui, Yifan; Wang, Shiyu; Che, Quande; Zhou, N.; Chen, Lingxin; Chen, Lingxin

Year: 2025

Venue: Small

DOI: https://doi.org/10.1002/smll.202501338

Paper Autoencoding Raman Spectra to Predict Analyte Concentrations

Poppe, Alex; Warren, C. H.; Brooks, W.S.M. et al. · 2025 · Journal of Raman Spectroscopy · DOI

Full title: Autoencoding Raman Spectra to Predict Analyte Concentrations

Authors: Poppe, Alex; Warren, C. H.; Brooks, W.S.M.; Gibson, Stuart; Foster, Michael J.

Year: 2025

Venue: Journal of Raman Spectroscopy

DOI: https://doi.org/10.1002/jrs.70003

Paper Process analytical technology (PAT) in insect and mammalian cell culture processes: dielectric spectroscopy and focused beam reflectance measurement (FBRM).

Druzinec, Damir; Weiss, Katja; Elseberg, Christiane et al. · 2014 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Process analytical technology (PAT) in insect and mammalian cell culture processes: dielectric spectroscopy and focused beam reflectance measurement (FBRM).

Authors: Druzinec, Damir; Weiss, Katja; Elseberg, Christiane; Salzig, Denise; Kraume, Matthias; Pörtner, Ralf; Czermak, Peter

Year: 2014

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-62703-733-4_20

Paper A novel rapid analysis using mass spectrometry to evaluate downstream refolding of recombinant human insulin-like growth factor-1 (mecasermin).

Furuki, Kenichiro; Toyo'oka, Toshimasa; Yamaguchi, Hideto · 2017 · Rapid communications in mass spectrometry : RCM · DOI

Full title: A novel rapid analysis using mass spectrometry to evaluate downstream refolding of recombinant human insulin-like growth factor-1 (mecasermin).

Authors: Furuki, Kenichiro; Toyo'oka, Toshimasa; Yamaguchi, Hideto

Year: 2017

Venue: Rapid communications in mass spectrometry : RCM

DOI: https://doi.org/10.1002/rcm.7906

Paper The choice of suitable online analytical techniques and data processing for monitoring of bioprocesses.

Marison, Ian; Hennessy, Siobhán; Foley, Róisín et al. · 2013 · Advances in biochemical engineering/biotechnology · DOI

Full title: The choice of suitable online analytical techniques and data processing for monitoring of bioprocesses.

Authors: Marison, Ian; Hennessy, Siobhán; Foley, Róisín; Schuler, Moira; Sivaprakasam, Senthilkumar; Freeland, Brian

Year: 2013

Venue: Advances in biochemical engineering/biotechnology

DOI: https://doi.org/10.1007/10_2012_175

Paper Multi-attribute PAT for UF/DF of Proteins-Monitoring Concentration, particle sizes, and Buffer Exchange.

Rolinger, Laura; Rüdt, Matthias; Diehm, Juliane et al. · 2020 · Analytical and bioanalytical chemistry · DOI

Full title: Multi-attribute PAT for UF/DF of Proteins-Monitoring Concentration, particle sizes, and Buffer Exchange.

Authors: Rolinger, Laura; Rüdt, Matthias; Diehm, Juliane; Chow-Hubbertz, Jessica; Heitmann, Martin; Schleper, Stefan; Hubbuch, Jürgen

Year: 2020

Venue: Analytical and bioanalytical chemistry

DOI: https://doi.org/10.1007/s00216-019-02318-8

Paper Multivariate data analysis of capacitance frequency scanning for online monitoring of viable cell concentrations in small-scale bioreactors

S. Metze; Stefanie Blioch; J. Matuszczyk et al. · 2019 · Analytical and Bioanalytical Chemistry · DOI

Full title: Multivariate data analysis of capacitance frequency scanning for online monitoring of viable cell concentrations in small-scale bioreactors

Authors: S. Metze; Stefanie Blioch; J. Matuszczyk; G. Greller; C. Grimm; J. Scholz; M. Hoehse

Year: 2019

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-019-02096-3

Paper Spectroscopic sensors for in-line bioprocess monitoring in research and pharmaceutical industrial application.

Claßen, Jens; Aupert, Florian; Reardon, Kenneth F et al. · 2017 · Analytical and bioanalytical chemistry · DOI

Full title: Spectroscopic sensors for in-line bioprocess monitoring in research and pharmaceutical industrial application.

Authors: Claßen, Jens; Aupert, Florian; Reardon, Kenneth F; Solle, Dörte; Scheper, Thomas

Year: 2017

Venue: Analytical and bioanalytical chemistry

DOI: https://doi.org/10.1007/s00216-016-0068-x

Paper Direct optical detection of cell density and viability of mammalian cells by means of UV/VIS spectroscopy.

Drieschner, Tobias; Ostertag, Edwin; Boldrini, Barbara et al. · 2020 · Analytical and bioanalytical chemistry · DOI

Full title: Direct optical detection of cell density and viability of mammalian cells by means of UV/VIS spectroscopy.

Authors: Drieschner, Tobias; Ostertag, Edwin; Boldrini, Barbara; Lorenz, Anita; Brecht, Marc; Rebner, Karsten

Year: 2020

Venue: Analytical and bioanalytical chemistry

DOI: https://doi.org/10.1007/s00216-019-02322-y

Paper Biomass measurement online: the performance of in situ measurements and software sensors

Kiviharju, Kristiina; Salonen, Kalle; Moilanen, Ulla et al. · 2008 · Journal of Industrial Microbiology & Biotechnology · DOI

Full title: Biomass measurement online: the performance of in situ measurements and software sensors

Authors: Kiviharju, Kristiina; Salonen, Kalle; Moilanen, Ulla; Eerikäinen, Tero

Year: 2008

Venue: Journal of Industrial Microbiology & Biotechnology

DOI: https://doi.org/10.1007/s10295-008-0346-5

Paper Use of near-infrared spectroscopy (NIRs) in the biopharmaceutical industry for real-time determination of critical process parameters and integration of advanced feedback control strategies using MIDUS control

Vann, Lucas; Sheppard, John D. · 2017 · Journal of Industrial Microbiology & Biotechnology · DOI

Full title: Use of near-infrared spectroscopy (NIRs) in the biopharmaceutical industry for real-time determination of critical process parameters and integration of advanced feedback control strategies using MIDUS control

Authors: Vann, Lucas; Sheppard, John D.

Year: 2017

Venue: Journal of Industrial Microbiology & Biotechnology

DOI: https://doi.org/10.1007/s10295-017-1984-2

Paper Chemometrics-based process analytical technology (PAT) tools: applications and adaptation in pharmaceutical and biopharmaceutical industries.

Challa, Shruthi; Potumarthi, Ravichandra · 2013 · Applied biochemistry and biotechnology · DOI

Full title: Chemometrics-based process analytical technology (PAT) tools: applications and adaptation in pharmaceutical and biopharmaceutical industries.

Authors: Challa, Shruthi; Potumarthi, Ravichandra

Year: 2013

Venue: Applied biochemistry and biotechnology

DOI: https://doi.org/10.1007/s12010-012-9950-y

Paper Development of sustained-release formulations processed by hot-melt extrusion by using a quality-by-design approach.

Islam, Muhammad T; Maniruzzaman, Mohammed; Halsey, Sheelagh A et al. · 2014 · Drug delivery and translational research · DOI

Full title: Development of sustained-release formulations processed by hot-melt extrusion by using a quality-by-design approach.

Authors: Islam, Muhammad T; Maniruzzaman, Mohammed; Halsey, Sheelagh A; Chowdhry, Babur Z; Douroumis, Dennis

Year: 2014

Venue: Drug delivery and translational research

DOI: https://doi.org/10.1007/s13346-014-0197-8

Paper Process analytical technology (PAT) tools: Uses in pharmaceutical manufacturing

S. S. Das; S. H. Alkahtani; A. Nayak et al. · 2021 · DOI

Full title: Process analytical technology (PAT) tools: Uses in pharmaceutical manufacturing

Authors: S. S. Das; S. H. Alkahtani; A. Nayak; Saquib Hasnain

Year: 2021

DOI: https://doi.org/10.1016/b978-0-12-820043-8.00007-4

Paper Advanced process design and understanding of continuous twin-screw granulation via implementation of in-line process analytical technologies

Wei Meng; Andrés D. Román-Ospino; Savitha S. Panikar et al. · 2019 · Advanced Powder Technology · DOI

Full title: Advanced process design and understanding of continuous twin-screw granulation via implementation of in-line process analytical technologies

Authors: Wei Meng; Andrés D. Román-Ospino; Savitha S. Panikar; Christopher P. O'Callaghan; Sean J. Gilliam; R. Ramachandran; F. Muzzio

Year: 2019

Venue: Advanced Powder Technology

DOI: https://doi.org/10.1016/j.apt.2019.01.017

Paper An integrated perspective on measuring cytokines to inform CAR-T bioprocessing

Williamson, Hannah K.; Mendes, Paula M. · 2024 · Biotechnology Advances · DOI

Full title: An integrated perspective on measuring cytokines to inform CAR-T bioprocessing

Authors: Williamson, Hannah K.; Mendes, Paula M.

Year: 2024

Venue: Biotechnology Advances

DOI: https://doi.org/10.1016/j.biotechadv.2024.108405

Paper Advances and opportunities in process analytical technologies for viral vector manufacturing.

Sripada, Sobhana A; Hosseini, Mahshid; Ramesh, Srivatsan et al. · 2024 · Biotechnology advances · DOI

Full title: Advances and opportunities in process analytical technologies for viral vector manufacturing.

Authors: Sripada, Sobhana A; Hosseini, Mahshid; Ramesh, Srivatsan; Wang, Junhyeong; Ritola, Kimberly; Menegatti, Stefano; Daniele, Michael A

Year: 2024

Venue: Biotechnology advances

DOI: https://doi.org/10.1016/j.biotechadv.2024.108391

Paper Towards real-time monitoring of therapeutic protein quality in mammalian cell processes.

Pais, Daniel A M; Carrondo, Manuel J T; Alves, Paula M et al. · 2014 · Current opinion in biotechnology · DOI

Full title: Towards real-time monitoring of therapeutic protein quality in mammalian cell processes.

Authors: Pais, Daniel A M; Carrondo, Manuel J T; Alves, Paula M; Teixeira, Ana P

Year: 2014

Venue: Current opinion in biotechnology

DOI: https://doi.org/10.1016/j.copbio.2014.06.019

Paper PAT-on-a-chip: Miniaturization of analytical assays towards data-driven bioprocess development and optimization.

Pinto, Inês F; Abeille, Fabien; Giehring, Sebastian et al. · 2025 · Biosensors & bioelectronics · DOI

Full title: PAT-on-a-chip: Miniaturization of analytical assays towards data-driven bioprocess development and optimization.

Authors: Pinto, Inês F; Abeille, Fabien; Giehring, Sebastian; Akhtar, Ahmad S; Sergeant, David; Chotteau, Veronique; Russom, Aman

Year: 2025

Venue: Biosensors & bioelectronics

DOI: https://doi.org/10.1016/j.bios.2025.117625

Paper Application of Raman spectroscopy during pharmaceutical process development for determination of critical quality attributes in Protein A chromatography.

Chen, Jingyi; Wang, Jiarui; Hess, Rudger et al. · 2024 · Journal of chromatography. A · DOI

Full title: Application of Raman spectroscopy during pharmaceutical process development for determination of critical quality attributes in Protein A chromatography.

Authors: Chen, Jingyi; Wang, Jiarui; Hess, Rudger; Wang, Gang; Studts, Joey; Franzreb, Matthias

Year: 2024

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2024.464721

Paper Harnessing Raman spectroscopy for cell therapy bioprocessing.

Costa, Marta H G; Carrondo, Inês; Isidro, Inês A et al. · 2024 · Biotechnology advances · DOI

Full title: Harnessing Raman spectroscopy for cell therapy bioprocessing.

Authors: Costa, Marta H G; Carrondo, Inês; Isidro, Inês A; Serra, Margarida

Year: 2024

Venue: Biotechnology advances

DOI: https://doi.org/10.1016/j.biotechadv.2024.108472

Paper Comparison of chemometrics strategies for the spectroscopic monitoring of active pharmaceutical ingredients in chemical reactions

Michel Thiel; N. Sauwen; Tastiana Khamiakova et al. · 2021 · Chemometrics and Intelligent Laboratory Systems · DOI

Full title: Comparison of chemometrics strategies for the spectroscopic monitoring of active pharmaceutical ingredients in chemical reactions

Authors: Michel Thiel; N. Sauwen; Tastiana Khamiakova; Tor Maes; B. Govaerts

Year: 2021

Venue: Chemometrics and Intelligent Laboratory Systems

DOI: https://doi.org/10.1016/j.chemolab.2021.104273

Paper Digital Butterworth filter as preprocessing method for implementing Raman spectroscopy as an analytical method in downstream processing of biopharmaceuticals.

Chen, Jingyi; Reyes, José Munoz; Schiemer, Robin et al. · 2025 · Journal of chromatography. A · DOI

Full title: Digital Butterworth filter as preprocessing method for implementing Raman spectroscopy as an analytical method in downstream processing of biopharmaceuticals.

Authors: Chen, Jingyi; Reyes, José Munoz; Schiemer, Robin; Wang, Gang; Studts, Joey; Franzreb, Matthias

Year: 2025

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2025.466069

Paper Knowing more from less: miniaturization of ligand-binding assays and electrophoresis as new paradigms for at-line monitoring and control of mammalian cell bioprocesses.

I. Pinto; Saara Mikkonen; Leila Josefsson et al. · 2021 · Current Opinion in Biotechnology · DOI

Full title: Knowing more from less: miniaturization of ligand-binding assays and electrophoresis as new paradigms for at-line monitoring and control of mammalian cell bioprocesses.

Authors: I. Pinto; Saara Mikkonen; Leila Josefsson; M. Mäkinen; R. Soares; A. Russom; Å. Emmer; V. Chotteau

Year: 2021

Venue: Current Opinion in Biotechnology

DOI: https://doi.org/10.1016/j.copbio.2021.06.018

Paper Proof-of-concept analytical instrument for label-free optical deconvolution of protein species in a mixture.

Hales, John E; Aoudjane, Samir; Aeppli, Gabriel et al. · 2021 · Journal of chromatography. A · DOI

Full title: Proof-of-concept analytical instrument for label-free optical deconvolution of protein species in a mixture.

Authors: Hales, John E; Aoudjane, Samir; Aeppli, Gabriel; Dalby, Paul A

Year: 2021

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2021.461968

Paper Antibody glycan quality predicted from CHO cell culture media markers and machine learning

Lakshmanan, Meiyappan; Chia, Sean; Pang, Kuin Tian et al. · 2024 · Computational and Structural Biotechnology Journal · DOI

Full title: Antibody glycan quality predicted from CHO cell culture media markers and machine learning

Authors: Lakshmanan, Meiyappan; Chia, Sean; Pang, Kuin Tian; Sim, Lyn Chiin; Teo, Gavin; Mak, Shi Ya; Chen, Shuwen; Lim, Hsueh Lee; Lee, Alison; Mahfut, Farouq Bin; Ng, Say Kong; Yang, Yuansheng; Soh, Annie; Tan, Andy Hee‐Meng; Choo, Andre; Ho, Ying Swan; Nguyen‐Khuong, Terry; Walsh, Ian

Year: 2024

Venue: Computational and Structural Biotechnology Journal

DOI: https://doi.org/10.1016/j.csbj.2024.05.046

Paper New unique PAT method and instrument for real-time inline size characterization of concentrated, flowing nanosuspensions.

Besseling, R; Damen, M; Wijgergangs, J et al. · 2019 · European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · DOI

Full title: New unique PAT method and instrument for real-time inline size characterization of concentrated, flowing nanosuspensions.

Authors: Besseling, R; Damen, M; Wijgergangs, J; Hermes, M; Wynia, G; Gerich, A

Year: 2019

Venue: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

DOI: https://doi.org/10.1016/j.ejps.2019.03.024

Paper PAT tools for the control of co-extrusion implants manufacturing process.

Krier, Fabrice; Mantanus, Jérôme; Sacré, Pierre-Yves et al. · 2013 · International journal of pharmaceutics · DOI

Full title: PAT tools for the control of co-extrusion implants manufacturing process.

Authors: Krier, Fabrice; Mantanus, Jérôme; Sacré, Pierre-Yves; Chavez, Pierre-François; Thiry, Justine; Pestieau, Aude; Rozet, Eric; Ziemons, Eric; Hubert, Philippe; Evrard, Brigitte

Year: 2013

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2013.09.040

Paper Process analytical technology as in-process control tool in semi-continuous manufacturing of PLGA/PEG-PLGA microspheres.

Anwar, Arfidin; Sun, Pengfei; Rong, Xiaoxu et al. · 2023 · Heliyon · DOI

Full title: Process analytical technology as in-process control tool in semi-continuous manufacturing of PLGA/PEG-PLGA microspheres.

Authors: Anwar, Arfidin; Sun, Pengfei; Rong, Xiaoxu; Arkin, Abdulaziz; Elham, Aliya; Yalkun, Zilala; Li, Xun; Iminjan, Mubarak

Year: 2023

Venue: Heliyon

DOI: https://doi.org/10.1016/j.heliyon.2023.e15753

Paper An examination of process models and model risk frameworks for pharmaceutical manufacturing

O’Connor, Thomas; Chatterjee, Sharmista; Lam, Johnny et al. · 2024 · International Journal of Pharmaceutics X · DOI

Full title: An examination of process models and model risk frameworks for pharmaceutical manufacturing

Authors: O’Connor, Thomas; Chatterjee, Sharmista; Lam, Johnny; Ossa, Dolores Hernán Pérez de la; Martinez-Peyrat, Leticia; Hoefnagel, Marcel H. N.; Fisher, Adam C.

Year: 2024

Venue: International Journal of Pharmaceutics X

DOI: https://doi.org/10.1016/j.ijpx.2024.100274

Paper In situ monitoring of cocrystals in formulation development using low-frequency Raman spectroscopy.

Otaki, Takashi; Tanabe, Yuta; Kojima, Takashi et al. · 2018 · International journal of pharmaceutics · DOI

Full title: In situ monitoring of cocrystals in formulation development using low-frequency Raman spectroscopy.

Authors: Otaki, Takashi; Tanabe, Yuta; Kojima, Takashi; Miura, Masaru; Ikeda, Yukihiro; Koide, Tatsuo; Fukami, Toshiro

Year: 2018

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2018.03.008

Paper Near Infrared Spectroscopy as a PAT tool for monitoring and control of protein and excipient concentration in ultrafiltration of highly concentrated antibody formulations.

Thakur, Garima; Hebbi, Vishwanath; Rathore, Anurag S · 2021 · International journal of pharmaceutics · DOI

Full title: Near Infrared Spectroscopy as a PAT tool for monitoring and control of protein and excipient concentration in ultrafiltration of highly concentrated antibody formulations.

Authors: Thakur, Garima; Hebbi, Vishwanath; Rathore, Anurag S

Year: 2021

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2021.120456

Paper Towards Point-of-Care Manufacturing and Analysis of Immediate-Release 3D Printed Hydrocortisone Tablets for The Treatment of Congenital Adrenal Hyperplasia.

Tzuyi L Yang; Melpomeni Stogiannari; Sylwia Janeczko et al. · 2023 · International journal of pharmaceutics · DOI

Full title: Towards Point-of-Care Manufacturing and Analysis of Immediate-Release 3D Printed Hydrocortisone Tablets for The Treatment of Congenital Adrenal Hyperplasia.

Authors: Tzuyi L Yang; Melpomeni Stogiannari; Sylwia Janeczko; Marva Khoshan; Yueyuan Lin; Abdullah Isreb; R. Habashy; Joanna Giebułtowic; M. Peak; M. Alhnan

Year: 2023

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2023.123072

Paper Power and fluid stress in disposable square stirred tank to streamline pharmaceutical process development.

M. Antognoli; Hessam Qeysari; F. Alberini et al. · 2025 · International journal of pharmaceutics · DOI

Full title: Power and fluid stress in disposable square stirred tank to streamline pharmaceutical process development.

Authors: M. Antognoli; Hessam Qeysari; F. Alberini; A. Paglianti; Pushpinder Singh; A. Albano

Year: 2025

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2025.126243

Paper Longitudinal two-dimensional gas chromatography mass spectrometry as a non-destructive at-line monitoring tool during cell manufacturing identifies volatile features correlative to cell product quality.

Jimenez, Angela C; Heist, Christopher A; Navaei, Milad et al. · 2022 · Cytotherapy · DOI

Full title: Longitudinal two-dimensional gas chromatography mass spectrometry as a non-destructive at-line monitoring tool during cell manufacturing identifies volatile features correlative to cell product quality.

Authors: Jimenez, Angela C; Heist, Christopher A; Navaei, Milad; Yeago, Carolyn; Roy, Krishnendu

Year: 2022

Venue: Cytotherapy

DOI: https://doi.org/10.1016/j.jcyt.2022.06.001

Paper Bridging process diversity in cell therapies toward standardization of manufacturing workflows.

Costa, Marta H G; Carrondo, Manuel J T; Alves, Paula M et al. · 2026 · Cytotherapy · DOI

Full title: Bridging process diversity in cell therapies toward standardization of manufacturing workflows.

Authors: Costa, Marta H G; Carrondo, Manuel J T; Alves, Paula M; Serra, Margarida

Year: 2026

Venue: Cytotherapy

DOI: https://doi.org/10.1016/j.jcyt.2025.102041

Paper The integration of artificial intelligence through quality by digital design for sustainable pharmaceutical manufacturing.

Abdulhussain, Rand; Muhamad, Haja; Fiza, Toaha et al. · 2026 · International journal of pharmaceutics · DOI

Full title: The integration of artificial intelligence through quality by digital design for sustainable pharmaceutical manufacturing.

Authors: Abdulhussain, Rand; Muhamad, Haja; Fiza, Toaha; Dereiah, Saedah; Mawla, Nihad; Patel, Krishan; Adebisi, Adeola; Asare-Addo, Kofi

Year: 2026

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2026.126682

Paper Raman spectroscopy for adaptive process control of adoptive T-cell immunotherapy manufacture

M. Baradez; N. Nicholas; R. Petrovic et al. · 2020 · DOI

Full title: Raman spectroscopy for adaptive process control of adoptive T-cell immunotherapy manufacture

Authors: M. Baradez; N. Nicholas; R. Petrovic; J. Churchwell; I. Evie; A. Keogh; D. Grandolfo; J. Sanchez-Nieto; R. Labbe; D. Biziato; Enas Hassan; D. Marshall

Year: 2020

DOI: https://doi.org/10.1016/j.jcyt.2020.03.217

Paper A universal digital control concept for end-to-end manufacturing.

Kuchler, L; Azimi, A; Damiri, H et al. · 2025 · International journal of pharmaceutics · DOI

Full title: A universal digital control concept for end-to-end manufacturing.

Authors: Kuchler, L; Azimi, A; Damiri, H; Martinuzzi, S; Steinberger, M; Rehrl, J; Poms, J; Kureck, M; Kirschneck, D; Horn, M; Khinast, J; Sacher, S

Year: 2025

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2025.125599

Paper Deployment of metabolic heat rate based soft sensor for estimation and control of specific growth rate in glycoengineered Pichia pastoris for human interferon alpha 2b production.

Allampalli, Pavan; Rathinavelu, Sivakumar; Mohan, Naresh et al. · 2022 · Journal of biotechnology · DOI

Full title: Deployment of metabolic heat rate based soft sensor for estimation and control of specific growth rate in glycoengineered Pichia pastoris for human interferon alpha 2b production.

Authors: Allampalli, Pavan; Rathinavelu, Sivakumar; Mohan, Naresh; Sivaprakasam, Senthilkumar

Year: 2022

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2022.10.006

Paper Real-time process monitoring in a semi-continuous fluid-bed dryer - microwave resonance technology versus near-infrared spectroscopy.

Peters, Johanna; Teske, Andreas; Taute, Wolfgang et al. · 2018 · International journal of pharmaceutics · DOI

Full title: Real-time process monitoring in a semi-continuous fluid-bed dryer - microwave resonance technology versus near-infrared spectroscopy.

Authors: Peters, Johanna; Teske, Andreas; Taute, Wolfgang; Döscher, Claas; Höft, Michael; Knöchel, Reinhard; Breitkreutz, Jörg

Year: 2018

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2017.12.040

Paper Early detection and metabolic pathway identification of T cell activation by in-process intracellular mass spectrometry.

Culberson, Austin L; Bowles-Welch, Annie C; Wang, Bryan et al. · 2023 · Cytotherapy · DOI

Full title: Early detection and metabolic pathway identification of T cell activation by in-process intracellular mass spectrometry.

Authors: Culberson, Austin L; Bowles-Welch, Annie C; Wang, Bryan; Kottke, Peter A; Jimenez, Angela C; Roy, Krishnendu; Fedorov, Andrei G

Year: 2023

Venue: Cytotherapy

DOI: https://doi.org/10.1016/j.jcyt.2023.03.010

Paper Development of process analytical technology to monitor the cell secretome during differentiation of pluripotent stem cells

C. P. Ricardo; I. Evie; M. Henry et al. · 2020 · DOI

Full title: Development of process analytical technology to monitor the cell secretome during differentiation of pluripotent stem cells

Authors: C. P. Ricardo; I. Evie; M. Henry; J. Sanchez-Nieto; M. Jayawardena; A. Soula; K. Daldoul; M. Arya; C. O'Grady; O. Dewhirst; M. Smart; M. Munye; J. Hasan

Year: 2020

DOI: https://doi.org/10.1016/j.jcyt.2020.03.049

Paper Automated vertical wheel bioreactor integrated with process analytics for T-cell manufacturing.

Wang, Bryan; Kanwar, Bharat; Bowles-Welch, Annie C et al. · 2025 · Cytotherapy · DOI

Full title: Automated vertical wheel bioreactor integrated with process analytics for T-cell manufacturing.

Authors: Wang, Bryan; Kanwar, Bharat; Bowles-Welch, Annie C; Byrnes, Walker; Costa, Paloma Casteleiro; Filan, Caroline; Tran, Reginald; Kotanchek, Theresa; Robles, Francisco; Roy, Krishnendu; Balakirsky, Stephen

Year: 2025

Venue: Cytotherapy

DOI: https://doi.org/10.1016/j.jcyt.2025.08.007

Paper Foundation model cascades enable zero-shot microscopy image analysis for cell therapy manufacturing.

R. Chen; Yeonju Lee; Benjamin Joffe et al. · 2026 · Cytotherapy · DOI

Full title: Foundation model cascades enable zero-shot microscopy image analysis for cell therapy manufacturing.

Authors: R. Chen; Yeonju Lee; Benjamin Joffe; Caroline E. Serafini; P. C. Costa; Bryan Wang; Bharat Kanwar; Stephen Balakirsky; Aaron D. Silva Trenkle; Linda E. Kippner; Isaac LeCompte; Ye Li; Christine Brown; Gabriel A. Kwong; F. Robles; Krishnendu Roy; Jing Li

Year: 2026

Venue: Cytotherapy

DOI: https://doi.org/10.1016/j.jcyt.2026.102078

Paper Comparative study of non-invasive monitoring via infrared spectroscopy for mammalian cell cultivations.

Sandor, M; Rüdinger, F; Bienert, R et al. · 2013 · Journal of biotechnology · DOI

Full title: Comparative study of non-invasive monitoring via infrared spectroscopy for mammalian cell cultivations.

Authors: Sandor, M; Rüdinger, F; Bienert, R; Grimm, C; Solle, D; Scheper, T

Year: 2013

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2013.08.002

Paper Development and validation of in-line near-infrared spectroscopy based analytical method for commercial production of a botanical drug product.

Zhang, Shunnan; Xiong, Haoshu; Zhou, Lihong et al. · 2019 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Development and validation of in-line near-infrared spectroscopy based analytical method for commercial production of a botanical drug product.

Authors: Zhang, Shunnan; Xiong, Haoshu; Zhou, Lihong; Ju, Wei; Yang, Zhexuan; Yan, Kaijing; Yan, Binjun; Qu, Haibin

Year: 2019

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2019.06.046

Paper Soft sensor for viable cell counting by measuring dynamic oxygen uptake rate.

Winter, M; Achleitner, L; Satzer, P · 2024 · New biotechnology · DOI

Full title: Soft sensor for viable cell counting by measuring dynamic oxygen uptake rate.

Authors: Winter, M; Achleitner, L; Satzer, P

Year: 2024

Venue: New biotechnology

DOI: https://doi.org/10.1016/j.nbt.2024.06.001

Paper Improving reliability of Raman spectroscopy for mAb production by upstream processes during bioprocess development stages.

Santos, Rafael M; Kaiser, Philipp; Menezes, Jose C et al. · 2019 · Talanta · DOI

Full title: Improving reliability of Raman spectroscopy for mAb production by upstream processes during bioprocess development stages.

Authors: Santos, Rafael M; Kaiser, Philipp; Menezes, Jose C; Peinado, Antonio

Year: 2019

Venue: Talanta

DOI: https://doi.org/10.1016/j.talanta.2019.02.088

Paper Use of Raman spectroscopy and PLS for the quantification of critical quality attributes in biopharmaceutical products.

Massei, Ambra; Falco, Nunzia; Fissore, Davide · 2026 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Use of Raman spectroscopy and PLS for the quantification of critical quality attributes in biopharmaceutical products.

Authors: Massei, Ambra; Falco, Nunzia; Fissore, Davide

Year: 2026

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2025.117185

Paper Real-time determination of critical quality attributes using near-infrared spectroscopy: a contribution for Process Analytical Technology (PAT).

Rosas, Juan G; Blanco, Marcel; González, Josep M et al. · 2012 · Talanta · DOI

Full title: Real-time determination of critical quality attributes using near-infrared spectroscopy: a contribution for Process Analytical Technology (PAT).

Authors: Rosas, Juan G; Blanco, Marcel; González, Josep M; Alcalà, Manel

Year: 2012

Venue: Talanta

DOI: https://doi.org/10.1016/j.talanta.2012.04.012

Paper Process Analytical Technologies and Data Analytics for the Manufacture of Monoclonal Antibodies.

Maruthamuthu, Murali K; Rudge, Scott R; Ardekani, Arezoo M et al. · 2020 · Trends in biotechnology · DOI

Full title: Process Analytical Technologies and Data Analytics for the Manufacture of Monoclonal Antibodies.

Authors: Maruthamuthu, Murali K; Rudge, Scott R; Ardekani, Arezoo M; Ladisch, Michael R; Verma, Mohit S

Year: 2020

Venue: Trends in biotechnology

DOI: https://doi.org/10.1016/j.tibtech.2020.07.004

Paper Near-infrared spectroscopy based monitoring of all 20 amino acids in mammalian cell culture broth.

Hubli, Geetanjali Basavaraj; Banerjee, Shantanu; Rathore, Anurag S · 2023 · Talanta · DOI

Full title: Near-infrared spectroscopy based monitoring of all 20 amino acids in mammalian cell culture broth.

Authors: Hubli, Geetanjali Basavaraj; Banerjee, Shantanu; Rathore, Anurag S

Year: 2023

Venue: Talanta

DOI: https://doi.org/10.1016/j.talanta.2022.124187

Paper Recent Advances in Biologic Therapeutic N-Glycan Preparation Techniques and Analytical Methods for Facilitating Biomanufacturing Automation.

Erin K. Tiwold; Aron Gyorgypal; Shishir P. S. Chundawat · 2023 · Journal of Pharmacy and Science · DOI

Full title: Recent Advances in Biologic Therapeutic N-Glycan Preparation Techniques and Analytical Methods for Facilitating Biomanufacturing Automation.

Authors: Erin K. Tiwold; Aron Gyorgypal; Shishir P. S. Chundawat

Year: 2023

Venue: Journal of Pharmacy and Science

DOI: https://doi.org/10.1016/j.xphs.2023.01.012

Paper Characterization of Protein Aggregation Using Hydrogel-Encapsulated nIR Fluorescent Nanoparticle Sensors.

Salem, Daniel P; Gong, Xun; Lee, Heejin et al. · 2020 · ACS sensors · DOI

Full title: Characterization of Protein Aggregation Using Hydrogel-Encapsulated nIR Fluorescent Nanoparticle Sensors.

Authors: Salem, Daniel P; Gong, Xun; Lee, Heejin; Zeng, Alicia; Xue, Gang; Schacherl, Jeff; Gibson, Scott; Strano, Michael S

Year: 2020

Venue: ACS sensors

DOI: https://doi.org/10.1021/acssensors.9b01586

Paper Excitation–Emission Matrix Fluorescence Spectroscopy Coupled with PARAFAC Modeling for Viability Prediction of Cells

Głowacz, Klaudia; Skorupska, Sandra; Grabowska‐Jadach, Ilona et al. · 2023 · ACS Omega · DOI

Full title: Excitation–Emission Matrix Fluorescence Spectroscopy Coupled with PARAFAC Modeling for Viability Prediction of Cells

Authors: Głowacz, Klaudia; Skorupska, Sandra; Grabowska‐Jadach, Ilona; Bro, Rasmus; Ciosek, Patrycja

Year: 2023

Venue: ACS Omega

DOI: https://doi.org/10.1021/acsomega.2c05383

Paper Artificial Intelligence in Pharmaceutical Manufacturing: Applications, Case Studies, and GxP Implementation Considerations.

Nakka, Gowtham; Gupta, Sakshi; Reddy, Katti Kartik · 2026 · Journal of pharmaceutical sciences · DOI

Full title: Artificial Intelligence in Pharmaceutical Manufacturing: Applications, Case Studies, and GxP Implementation Considerations.

Authors: Nakka, Gowtham; Gupta, Sakshi; Reddy, Katti Kartik

Year: 2026

Venue: Journal of pharmaceutical sciences

DOI: https://doi.org/10.1016/j.xphs.2026.104240

Paper On-Line Ion Exchange Liquid Chromatography as a Process Analytical Technology for Monoclonal Antibody Characterization in Continuous Bioprocessing.

Patel, Bhumit A; Pinto, Nuno D S; Gospodarek, Adrian et al. · 2017 · Analytical chemistry · DOI

Full title: On-Line Ion Exchange Liquid Chromatography as a Process Analytical Technology for Monoclonal Antibody Characterization in Continuous Bioprocessing.

Authors: Patel, Bhumit A; Pinto, Nuno D S; Gospodarek, Adrian; Kilgore, Bruce; Goswami, Kudrat; Napoli, William N; Desai, Jayesh; Heo, Jun H; Panzera, Dominick; Pollard, David; Richardson, Daisy; Brower, Mark; Richardson, Douglas D

Year: 2017

Venue: Analytical chemistry

DOI: https://doi.org/10.1021/acs.analchem.7b02228

Paper Real-Time Bioconjugation Reaction Monitoring of Antibody-Drug Conjugates with Multiattribute High-Throughput Hydrophobic Interaction Chromatography.

Cadang, Lance; Li, Songman; Wang, Jenny et al. · 2025 · Analytical chemistry · DOI

Full title: Real-Time Bioconjugation Reaction Monitoring of Antibody-Drug Conjugates with Multiattribute High-Throughput Hydrophobic Interaction Chromatography.

Authors: Cadang, Lance; Li, Songman; Wang, Jenny; Stumpf, Andreas; Kempen, Trevor; Dai, Lulu; Bouskila, Alan; Meadows, Corey W; Breton, Abbie; Yi, Lian; Fan, Yuchen; Chen, Tao; Zhang, Kelly; Wei, Bingchuan

Year: 2025

Venue: Analytical chemistry

DOI: https://doi.org/10.1021/acs.analchem.5c03553

Paper Toward biotherapeutic product real-time quality monitoring.

Guerra, André; von Stosch, Moritz; Glassey, Jarka · 2019 · Critical reviews in biotechnology · DOI

Full title: Toward biotherapeutic product real-time quality monitoring.

Authors: Guerra, André; von Stosch, Moritz; Glassey, Jarka

Year: 2019

Venue: Critical reviews in biotechnology

DOI: https://doi.org/10.1080/07388551.2018.1524362

Paper In-line product quality monitoring during biopharmaceutical manufacturing using computational Raman spectroscopy

Jiarui Wang; Jingyi Chen; J. Studts et al. · 2023 · mAbs · DOI

Full title: In-line product quality monitoring during biopharmaceutical manufacturing using computational Raman spectroscopy

Authors: Jiarui Wang; Jingyi Chen; J. Studts; G. Wang

Year: 2023

Venue: mAbs

DOI: https://doi.org/10.1080/19420862.2023.2220149

Paper Development of automated metabolite control using mid-infrared probe for bioprocesses and vaccine manufacturing

Reid, Jennifer; Haer, Manjit; CHEN, A. et al. · 2024 · Journal of Industrial Microbiology & Biotechnology · DOI

Full title: Development of automated metabolite control using mid-infrared probe for bioprocesses and vaccine manufacturing

Authors: Reid, Jennifer; Haer, Manjit; CHEN, A.; Adams, Calvin; Lin, Yu Chen; Cronin, J.F.; Yu, Zhou; Kirkitadze, Marina; Yuan, Tao

Year: 2024

Venue: Journal of Industrial Microbiology & Biotechnology

DOI: https://doi.org/10.1093/jimb/kuae019

Paper Application of recurrent neural network for online prediction of cell density of recombinant Pichia pastoris producing HBsAg

A. Beiroti; M. Aghasadeghi; S. Hosseini et al. · 2019 · Preparative Biochemistry & Biotechnology · DOI

Full title: Application of recurrent neural network for online prediction of cell density of recombinant Pichia pastoris producing HBsAg

Authors: A. Beiroti; M. Aghasadeghi; S. Hosseini; D. Norouzian

Year: 2019

Venue: Preparative Biochemistry & Biotechnology

DOI: https://doi.org/10.1080/10826068.2019.1566153

Paper A framework for transferring sinomenine hydrochloride sustained-release tablet from batch to continuous direct compression manufacturing.

Zhou, Guoming; Chang, Hao; Fang, Guangpu et al. · 2026 · Drug development and industrial pharmacy · DOI

Full title: A framework for transferring sinomenine hydrochloride sustained-release tablet from batch to continuous direct compression manufacturing.

Authors: Zhou, Guoming; Chang, Hao; Fang, Guangpu; Cai, Xingshi; Rong, Zhigang; Li, Wenlong

Year: 2026

Venue: Drug development and industrial pharmacy

DOI: https://doi.org/10.1080/03639045.2026.2629616

Paper Perspectives of fluorescence spectroscopy for online monitoring in microalgae industry

Sá, Marta; Ferrer-Ledo, Narcís; Gao, Fengzheng et al. · 2022 · Microbial Biotechnology · DOI

Full title: Perspectives of fluorescence spectroscopy for online monitoring in microalgae industry

Authors: Sá, Marta; Ferrer-Ledo, Narcís; Gao, Fengzheng; Bertinetto‬, ‪Carlo; Jansen, Jeroen J.; Crespo, João G.; Wijffels, René H.; Barbosa, María J.; Galinha, Cláudia F.

Year: 2022

Venue: Microbial Biotechnology

DOI: https://doi.org/10.1111/1751-7915.14013

Paper Using Compact 1H NMR, NIR, and Raman Spectroscopy Combined with Multivariate Data Analysis to Monitor a Biocatalyzed Reaction in a Microreaction System

Legner, Robin; Wirtz, Alexander; Jaeger, Martin · 2018 · Journal of Spectroscopy · DOI

Full title: Using Compact 1H NMR, NIR, and Raman Spectroscopy Combined with Multivariate Data Analysis to Monitor a Biocatalyzed Reaction in a Microreaction System

Authors: Legner, Robin; Wirtz, Alexander; Jaeger, Martin

Year: 2018

Venue: Journal of Spectroscopy

DOI: https://doi.org/10.1155/2018/5120789

Paper Rapid and Nondestructive Detection of Proline in Serum Using Near‐Infrared Spectroscopy and Partial Least Squares

Zhu, Kejing; Zhang, Shengsheng; Yue, Keyu et al. · 2022 · Journal of Analytical Methods in Chemistry · DOI

Full title: Rapid and Nondestructive Detection of Proline in Serum Using Near‐Infrared Spectroscopy and Partial Least Squares

Authors: Zhu, Kejing; Zhang, Shengsheng; Yue, Keyu; Zuo, Yaming; Niu, Yulin; Wu, Qing; Pan, Wei

Year: 2022

Venue: Journal of Analytical Methods in Chemistry

DOI: https://doi.org/10.1155/2022/4610140

Paper Development of Raman Calibration Model Without Culture Data for In-Line Analysis of Metabolites in Cell Culture Media

Hara, Risa; Kobayashi, Wataru; Yamanaka, Hiroaki et al. · 2023 · Applied Spectroscopy · DOI

Full title: Development of Raman Calibration Model Without Culture Data for In-Line Analysis of Metabolites in Cell Culture Media

Authors: Hara, Risa; Kobayashi, Wataru; Yamanaka, Hiroaki; Murayama, Kodai; Shimoda, Soichiro; Ozaki, Yukihiro

Year: 2023

Venue: Applied Spectroscopy

DOI: https://doi.org/10.1177/00037028231160197

Paper Calibration Transfer Across Instrument Vendors for Bioprocess Raman Monitoring

Nathaniel M. Myers; Beibei Gao; Daniel Amchin et al. · 2025 · AAPS Journal · DOI

Full title: Calibration Transfer Across Instrument Vendors for Bioprocess Raman Monitoring

Authors: Nathaniel M. Myers; Beibei Gao; Daniel Amchin; Erin M Masucci; Karin M Balss

Year: 2025

Venue: AAPS Journal

DOI: https://doi.org/10.1208/s12248-025-01156-0

Paper Multivariate data analysis of near-infrared spectra of cultivation medium powders for mammalian cells

Szabó, Éva; Gergely, Szilveszter; Salgó, András · 2019 · IM Publications Open LLP eBooks · DOI

Full title: Multivariate data analysis of near-infrared spectra of cultivation medium powders for mammalian cells

Authors: Szabó, Éva; Gergely, Szilveszter; Salgó, András

Year: 2019

Venue: IM Publications Open LLP eBooks

DOI: https://doi.org/10.1255/nir2017.143

Paper Development of rapid spectroscopic methods for the analysis of cell culture media

Kissane, Bridget · 2014 · Arrow@dit (Dublin Institute of Technology) · DOI

Full title: Development of rapid spectroscopic methods for the analysis of cell culture media

Authors: Kissane, Bridget

Year: 2014

Venue: Arrow@dit (Dublin Institute of Technology)

DOI: https://doi.org/10.13025/16018

Paper Einsatz der IR-Spektroskopie bei der Prozessverfolgung von Hefe-Fermentationen sowie bei der Qualitätskontrolle von Getränken,Obst und Hefen

Egly, Dominik · 2012 · DepositOnce · DOI

Full title: Einsatz der IR-Spektroskopie bei der Prozessverfolgung von Hefe-Fermentationen sowie bei der Qualitätskontrolle von Getränken,Obst und Hefen

Authors: Egly, Dominik

Year: 2012

Venue: DepositOnce

DOI: https://doi.org/10.14279/depositonce-3239

Paper Monitoring lactic acid concentrations by infrared spectroscopy: A new developed method for Lactobacillus fermenting media with potential food applications

Păucean, Adriana; Vodnar, Dan Cristian; Mureşan, Vlad et al. · 2017 · Acta Alimentaria · DOI

Full title: Monitoring lactic acid concentrations by infrared spectroscopy: A new developed method for Lactobacillus fermenting media with potential food applications

Authors: Păucean, Adriana; Vodnar, Dan Cristian; Mureşan, Vlad; Fetea, Florinela; Ranga, Floricuța; MAN, Simona; MUSTE, Sevastița; Socaciu, Carmen

Year: 2017

Venue: Acta Alimentaria

DOI: https://doi.org/10.1556/066.2017.0003

Paper Tumor-infiltrating lymphocyte therapies: personal, powerful, with possibilities for improvement

S. Ribeiro; Therese Choquette · 2025 · Cell and Gene Therapy Insights · DOI

Full title: Tumor-infiltrating lymphocyte therapies: personal, powerful, with possibilities for improvement

Authors: S. Ribeiro; Therese Choquette

Year: 2025

Venue: Cell and Gene Therapy Insights

DOI: https://doi.org/10.18609/cgti.2025.124

Paper Bioprozessanalytik mittels Raman- und MIR-ATR-Spektroskopie

Schalk, R.M. · 2019 · DepositOnce · DOI

Full title: Bioprozessanalytik mittels Raman- und MIR-ATR-Spektroskopie

Authors: Schalk, R.M.

Year: 2019

Venue: DepositOnce

DOI: https://doi.org/10.14279/depositonce-7823

Paper Machine Learning algorithms for in-line monitoring during Yeast Fermentations based on Raman Spectroscopy

Wu, Debiao; Xu, Yaying; Xu, Feng et al. · 2023 · Research Square (Research Square) · DOI

Full title: Machine Learning algorithms for in-line monitoring during Yeast Fermentations based on Raman Spectroscopy

Authors: Wu, Debiao; Xu, Yaying; Xu, Feng; Shao, Minghao; Huang, Mingzhi

Year: 2023

Venue: Research Square (Research Square)

DOI: https://doi.org/10.21203/rs.3.rs-2615036/v1

Paper Exploring multiple bioprocess monitoring modalities for Large-scale 3D Bioprinted Tissue Cultivation

Chastagnier, Laura; Pragnère, Sarah; Gimènez, Yilbert et al. · 2024 · Research Square (Research Square) · DOI

Full title: Exploring multiple bioprocess monitoring modalities for Large-scale 3D Bioprinted Tissue Cultivation

Authors: Chastagnier, Laura; Pragnère, Sarah; Gimènez, Yilbert; Loubière, Céline; el-Kholti, Naima; Mazarakis, Kleanthis; Schmidberger, Timo; Olmos, Éric; Lambert, Simon A.; Marquette, Christophe A.; Petiot, Emma

Year: 2024

Venue: Research Square (Research Square)

DOI: https://doi.org/10.21203/rs.3.rs-4021195/v1

Paper Real-time and on-line parallel detection of key fermentation process parameters by near-infrared spectroscopy in different environments

Chen, Yang; Chen, Lingli; Guo, Meijin et al. · 2021 · Research Square (Research Square) · DOI

Full title: Real-time and on-line parallel detection of key fermentation process parameters by near-infrared spectroscopy in different environments

Authors: Chen, Yang; Chen, Lingli; Guo, Meijin; Li, Xu; Liu, Jinsong; Liu, Xiaofeng; Chen, Zhongbing; Tian, Xiaojun; Zheng, Haoyue; Tian, Xiwei; Chu, Ju; Zhuang, Yingping

Year: 2021

Venue: Research Square (Research Square)

DOI: https://doi.org/10.21203/rs.3.rs-507588/v1

Paper A hierarchical model combining process and Raman spectroscopic data for real-time monitoring of cell culture process

Yin, Pei; Tong, Jing; Zhang, Liwei et al. · 2023 · DOI

Full title: A hierarchical model combining process and Raman spectroscopic data for real-time monitoring of cell culture process

Authors: Yin, Pei; Tong, Jing; Zhang, Liwei; Tang, Weihua; Jiang, Pei; Wan, Xun; Guo, Meijin

Year: 2023

DOI: https://doi.org/10.21203/rs.3.rs-3532087/v1

Paper Real-time and on-line monitoring of ethanol fermentation process by viable cell sensor and electronic nose

Feng, Yao; Tian, Xiwei; Chen, Yang et al. · 2021 · Bioresources and Bioprocessing · DOI

Full title: Real-time and on-line monitoring of ethanol fermentation process by viable cell sensor and electronic nose

Authors: Feng, Yao; Tian, Xiwei; Chen, Yang; Wang, Zeyu; Xia, Jianye; Qian, Jiangchao; Zhuang, Yingping; Chu, Ju

Year: 2021

Venue: Bioresources and Bioprocessing

DOI: https://doi.org/10.1186/s40643-021-00391-5

Paper Optics miniaturization strategy for demanding Raman spectroscopy applications

Ilchenko, Oleksii; Pilhun, Yurii; Kutsyk, Andrii et al. · 2024 · Nature Communications · DOI

Full title: Optics miniaturization strategy for demanding Raman spectroscopy applications

Year: 2024

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-024-47044-7

Paper Articulation of Quality By Design Elements for Product Development and its Unique Applications

Sitre, Dnyaneshwar G; Kamble, Ravindra K · 2020 · Journal of Drug Delivery and Therapeutics · DOI

Full title: Articulation of Quality By Design Elements for Product Development and its Unique Applications

Authors: Sitre, Dnyaneshwar G; Kamble, Ravindra K

Year: 2020

Venue: Journal of Drug Delivery and Therapeutics

DOI: https://doi.org/10.22270/jddt.v10i3.4080

Paper Spectroscopy as a tool for process development and control in cultured meat production by analyzing media composition

Andersen, Petter Vejle; Wubshet, Sileshi Gizachew; Tzimorotas, Dimitrios et al. · 2025 · DOI

Full title: Spectroscopy as a tool for process development and control in cultured meat production by analyzing media composition

Authors: Andersen, Petter Vejle; Wubshet, Sileshi Gizachew; Tzimorotas, Dimitrios; Dankel, Katinka R.; Afseth, Nils Kristian; Wold, Jens Petter; Rønning, Sissel Beate

Year: 2025

DOI: https://doi.org/10.21203/rs.3.rs-6123711/v1

Paper Monitoring PHB production in Synechocystis sp. with hyperspectral images

Lorenzo, Francisco Rodríguez; Lorenzo, Miguel Placer; Castilla, Luz Herrero et al. · 2022 · Water Science & Technology · DOI

Full title: Monitoring PHB production in Synechocystis sp. with hyperspectral images

Authors: Lorenzo, Francisco Rodríguez; Lorenzo, Miguel Placer; Castilla, Luz Herrero; Rodríguez, Juan Antonio Álvarez; Iglesias, Sandra; Gómez-Cuervo, Santiago; Montenegro, Juan Manuel Fernández; Rueda, Estel; Díez-Montero, Rubén; Garcı́a, Joan; Gonzalez-Flo, Eva

Year: 2022

Venue: Water Science & Technology

DOI: https://doi.org/10.2166/wst.2022.194

Paper Raman (Rs) Spectroscopy for Biopharmaceutical Quality Control and PAT. Raw Material - Final Products: the Nanolipids Effect on Signal Intensity. Regulatory and Toxicological Aspects

Luisetto, M · 2022 · Medicinal & Analytical Chemistry International · DOI

Full title: Raman (Rs) Spectroscopy for Biopharmaceutical Quality Control and PAT. Raw Material - Final Products: the Nanolipids Effect on Signal Intensity. Regulatory and Toxicological Aspects

Authors: Luisetto, M

Year: 2022

Venue: Medicinal & Analytical Chemistry International

DOI: https://doi.org/10.23880/macij-16000175

Paper Monitoring Cell Development via In Situ Localized Sampling

Mason A Chilmonczyk; Gilad Doron; P. Kottke et al. · 2020 · DOI

Full title: Monitoring Cell Development via In Situ Localized Sampling

Authors: Mason A Chilmonczyk; Gilad Doron; P. Kottke; A. Culberson; Kelly E Leguineche; R. Guldberg; E. Horwitz; A. Fedorov

Year: 2020

DOI: https://doi.org/10.22541/au.159225468.87424839

Paper Online/At-line Measurement, Analysis and Control of Product Titer & Critical Product Quality Attributes (CQAs) During Process Development

Letha Chemmalil · 2020 · DOI

Full title: Online/At-line Measurement, Analysis and Control of Product Titer & Critical Product Quality Attributes (CQAs) During Process Development

Authors: Letha Chemmalil

Year: 2020

DOI: https://doi.org/10.22541/au.159410541.13429511

Paper Probing multivalent particle–surface interactions using a quartz crystal resonator

Da-Silva-Granja, Carlos António · 2019 · DOI

Full title: Probing multivalent particle–surface interactions using a quartz crystal resonator

Authors: Da-Silva-Granja, Carlos António

Year: 2019

DOI: https://doi.org/10.26174/thesis.lboro.8323562.v1

Paper Uncovering the Impact of Spectroscopic Data Reduction Techniques on the Process Control Mode Pattern Recognition: The Case of Industrial Penicillin Production

Vishakha, Vishakha; Jančář, Josef · 2024 · DOI

Full title: Uncovering the Impact of Spectroscopic Data Reduction Techniques on the Process Control Mode Pattern Recognition: The Case of Industrial Penicillin Production

Authors: Vishakha, Vishakha; Jančář, Josef

Year: 2024

DOI: https://doi.org/10.26434/chemrxiv-2024-c1b8w

Paper Modeling of a spiral resonant sensor for biological process monitoring

Elsherbiny, Omar Hesham · 2022 · DOI

Full title: Modeling of a spiral resonant sensor for biological process monitoring

Authors: Elsherbiny, Omar Hesham

Year: 2022

DOI: https://doi.org/10.31274/td-20240329-514

Paper Bioprocess monitoring using sequential injection capillary electrophoresis

Alhusban, Aaa · 2023 · Open Access Repository (University of Tasmania) · DOI

Full title: Bioprocess monitoring using sequential injection capillary electrophoresis

Authors: Alhusban, Aaa

Year: 2023

Venue: Open Access Repository (University of Tasmania)

DOI: https://doi.org/10.25959/23239175

Paper Development of soft sensors for monitoring and control of bioprocesses

Gustavsson, Robert · 2018 · DOI

Full title: Development of soft sensors for monitoring and control of bioprocesses

Authors: Gustavsson, Robert

Year: 2018

DOI: https://doi.org/10.3384/diss.diva-152439

Paper Real-time in situ monitoring of CRM-197 and polysaccharide conjugation reaction by fluorescence spectroscopy.

Saha-Shah, Anumita; Smith, Joseph P; Konietzko, Janelle et al. · 2023 · Bioanalysis · DOI

Full title: Real-time in situ monitoring of CRM-197 and polysaccharide conjugation reaction by fluorescence spectroscopy.

Authors: Saha-Shah, Anumita; Smith, Joseph P; Konietzko, Janelle; Costell, Emily; McHugh, Patrick M; Lo-Mont, Justin P; Ralbovsky, Nicole M; Obando, Louis; Wang, Sheng-Ching; Appiah-Amponsah, Emmanuel; Mangion, Ian

Year: 2023

Venue: Bioanalysis

DOI: https://doi.org/10.4155/bio-2023-0010

Paper A Bluetooth Low-Energy Wireless Sensor Platform for Continuous Monitoring of a Bioreactor Environment during Cell Manufacturing

Nelson, Brad H. · 2018 · DOI

Full title: A Bluetooth Low-Energy Wireless Sensor Platform for Continuous Monitoring of a Bioreactor Environment during Cell Manufacturing

Authors: Nelson, Brad H.

Year: 2018

DOI: https://doi.org/10.37099/mtu.dc.etdr/609

Paper Process analytical technology (PAT) for CGT: User requirements specifications

Benjamin Ross-Johnsrud; B. Silva; Dan Some et al. · 2025 · DOI

Full title: Process analytical technology (PAT) for CGT: User requirements specifications

Authors: Benjamin Ross-Johnsrud; B. Silva; Dan Some; J. Hasan; Jakob Heckel; Jay A. A. West; Jochen Scholz; Madeline Ostrom; Mohiuddin Mohiuddin; Moira Lynch; Rafael A Masitas; R. Gopalakrishnan; Sameer Hadawale; Wilson Li; Zhijie Wu

Year: 2025

DOI: https://doi.org/10.46220/2025atmp007

Paper QbD Approach in Method Development

Aishwarya Reddy; Shikha Saxena · 2026 · Research Journal of Pharmacy and Technology · DOI

Full title: QbD Approach in Method Development

Authors: Aishwarya Reddy; Shikha Saxena

Year: 2026

Venue: Research Journal of Pharmacy and Technology

DOI: https://doi.org/10.52711/0974-360x.2026.00067

Paper A Critical Review on Recently Used PAT in Pharmaceutical Industry

Arti Swami; Shivani Chakankar; Prajakta Chavan et al. · 2023 · Research Journal of Pharmacy and Technology · DOI

Full title: A Critical Review on Recently Used PAT in Pharmaceutical Industry

Authors: Arti Swami; Shivani Chakankar; Prajakta Chavan; Dnyanesh Limaye; A. Tagalpallewar

Year: 2023

Venue: Research Journal of Pharmacy and Technology

DOI: https://doi.org/10.52711/0974-360x.2023.00724

Paper An Overview on Quality by Design in Pharmaceutical Product Development

P. Mallikarjun; P. Kumari; S. Kumar et al. · 2025 · Journal of Chemical Health Risks · DOI

Full title: An Overview on Quality by Design in Pharmaceutical Product Development

Authors: P. Mallikarjun; P. Kumari; S. Kumar; G. Sowmya

Year: 2025

Venue: Journal of Chemical Health Risks

DOI: https://doi.org/10.52783/jchr.v15.i1.7345

Paper Limitations of Joint and Dual Nonlinear Kalman Estimators in Low-Cost Bioprocess Monitoring

Iglesias, Cristovão Freitas; Pessoa, L. M.; Miceli, Claudio et al. · 2024 · DOI

Full title: Limitations of Joint and Dual Nonlinear Kalman Estimators in Low-Cost Bioprocess Monitoring

Authors: Iglesias, Cristovão Freitas; Pessoa, L. M.; Miceli, Claudio; Bolić, Miodrag

Year: 2024

DOI: https://doi.org/10.52591/lxai202407273

Paper Quality by Design Approch Based in Analytical Method Validation

Prerana Musale; S. Mankar · 2023 · Asian Journal of Pharmaceutical Analysis · DOI

Full title: Quality by Design Approch Based in Analytical Method Validation

Authors: Prerana Musale; S. Mankar

Year: 2023

Venue: Asian Journal of Pharmaceutical Analysis

DOI: https://doi.org/10.52711/2231-5675.2023.00031

Paper - **DOI:** 10.5281/zenodo.5176016 - **Authors:** Y. AchyuthaValliDevi, M. SaiRamya, Likitha, S. NatrajK - **Year:** 2021 - **Journal:** N/A

Y. AchyuthaValliDevi; M. SaiRamya; Likitha et al. · 2021 · DOI

Full title: - **DOI:** 10.5281/zenodo.5176016 - **Authors:** Y. AchyuthaValliDevi, M. SaiRamya, Likitha, S. NatrajK - **Year:** 2021 - **Journal:** N/A

Authors: Y. AchyuthaValliDevi; M. SaiRamya; Likitha; S. NatrajK

Year: 2021

DOI: https://doi.org/10.5281/zenodo.5176016

Paper Online HPLC–HRMS Platform: The Next-Generation Process Analytical Technology Tool for Real-Time Monitoring of Antibody Quality Attributes in Biopharmaceutical Processes

Julien Camperi · 2022 · LCGC North America · DOI

Full title: Online HPLC–HRMS Platform: The Next-Generation Process Analytical Technology Tool for Real-Time Monitoring of Antibody Quality Attributes in Biopharmaceutical Processes

Authors: Julien Camperi

Year: 2022

Venue: LCGC North America

DOI: https://doi.org/10.56530/lcgc.na.op5766f2

Paper PAT-on-a-chip: Miniaturization of analytical assays towards data-driven bioprocess development and optimization.

Pinto, Inês F; Abeille, Fabien; Giehring, Sebastian et al. · 2025 · Biosensors & bioelectronics · DOI

Full title: PAT-on-a-chip: Miniaturization of analytical assays towards data-driven bioprocess development and optimization.

Authors: Pinto, Inês F; Abeille, Fabien; Giehring, Sebastian; Akhtar, Ahmad S; Sergeant, David; Chotteau, Veronique; Russom, Aman

Year: 2025

Venue: Biosensors & bioelectronics

DOI: https://doi.org/10.1016/j.bios.2025.117625

Paper Aplicações da espectroscopia de infravermelho próximo em Ciências Farmacêuticas

Leitão, Tiago Miguel Dinis · 2012 · Repositorio Institucional (Universidade Fernando Pessoa)

Full title: Aplicações da espectroscopia de infravermelho próximo em Ciências Farmacêuticas

Authors: Leitão, Tiago Miguel Dinis

Year: 2012

Venue: Repositorio Institucional (Universidade Fernando Pessoa)

Paper Computationally aided reliability analysis of sensor data using multivariate data analysis and modelling approaches for bioprocesses

Krause, Daniel · 2018 · mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)

Full title: Computationally aided reliability analysis of sensor data using multivariate data analysis and modelling approaches for bioprocesses

Authors: Krause, Daniel

Year: 2018

Venue: mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)

Paper Design, Fabrication and Assessment of a Short Tank Internally-Illuminated Concentric-Tube Airlift Photobioreactor for the Cultivation of Spirulina platensis

Bataller, Butch G. · 2018 · OakTrust (Texas A&M University Libraries)

Full title: Design, Fabrication and Assessment of a Short Tank Internally-Illuminated Concentric-Tube Airlift Photobioreactor for the Cultivation of Spirulina platensis

Authors: Bataller, Butch G.

Year: 2018

Venue: OakTrust (Texas A&M University Libraries)

Paper Farmasötik İlaçlar İçin Non invasif Kalite Kontrol Yöntemlerinin Tasarlanması

Hani, ALAM, · 2024 · OpenMETU (Middle East Technical University)

Full title: Farmasötik İlaçlar İçin Non invasif Kalite Kontrol Yöntemlerinin Tasarlanması

Authors: Hani, ALAM,

Year: 2024

Venue: OpenMETU (Middle East Technical University)

Paper Fourier transform infrared spectroscopy, a powerful tool to monitor biopharmaceuticals production

Sales, Kevin C. · 2014 · Repositório Institucional da Universidade Católica Portuguesa (Universidade Católica Portuguesa)

Full title: Fourier transform infrared spectroscopy, a powerful tool to monitor biopharmaceuticals production

Authors: Sales, Kevin C.

Year: 2014

Venue: Repositório Institucional da Universidade Católica Portuguesa (Universidade Católica Portuguesa)

Paper PAT (Process Analytical Technology) in bioprocess industry

김효진 · 2009 · 한국생물공학회 학술대회

Full title: PAT (Process Analytical Technology) in bioprocess industry

Authors: 김효진

Year: 2009

Venue: 한국생물공학회 학술대회

Thesis A Systematic Framework to Optimize and Control Monoclonal Antibody Manufacturing Process

Li, Ying Fei · 2018 · Columbia University · DOI

Full title: A Systematic Framework to Optimize and Control Monoclonal Antibody Manufacturing Process

Authors: Li, Ying Fei

Year: 2018

Venue: Columbia University

DOI: https://doi.org/10.7916/D8GX5TJP

Thesis Continuous Online Protein Quality Monitoring during Perfusion Culture Production Using an Integrated Micro/Nanofluidic System

Kwon, Taehong; Ko, Sung Hee; Hamel, Jean-Francois P et al. · 2020 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Continuous Online Protein Quality Monitoring during Perfusion Culture Production Using an Integrated Micro/Nanofluidic System

Authors: Kwon, Taehong; Ko, Sung Hee; Hamel, Jean-Francois P; Han, Jongyoon

Year: 2020

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/125538

Thesis Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra

Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn et al. · 2021 · Utrecht University · DOI

Authors: Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn; Mastrobattista, Enrico; Yamabhai, Montarop

Year: 2021

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/418108

Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn et al. · 2021 · Utrecht University · DOI

Authors: Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn; Mastrobattista, Enrico; Yamabhai, Montarop

Year: 2021

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/419433

Thesis Spectroscopic approach for dynamic bioanalyte tracking with minimal concentration information

Spegazzini, Nicolas; Barman, Ishan; Dingari, Narahara Chari et al. · 2014 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Spectroscopic approach for dynamic bioanalyte tracking with minimal concentration information

Authors: Spegazzini, Nicolas; Barman, Ishan; Dingari, Narahara Chari; Pandey, Rishikesh; Soares, Jaqueline S.; Ozaki, Yukihiro; Dasari, Ramachandra Rao

Year: 2014

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/92575

Thesis Continuous reaction monitoring by dielectric spectroscopy

Dalligos, Desiree · 2024 · University of Nottingham · DOI

Full title: Continuous reaction monitoring by dielectric spectroscopy

Authors: Dalligos, Desiree

Year: 2024

Venue: University of Nottingham

DOI: https://eprints.nottingham.ac.uk/77036/1/Desiree%20Dalligos%2014342637%20thesis%20final.pdf

Thesis Confocal Raman imaging of live cells

Zoladek, Alina · 2011 · University of Nottingham · DOI

Full title: Confocal Raman imaging of live cells

Authors: Zoladek, Alina

Year: 2011

Venue: University of Nottingham

DOI: https://eprints.nottingham.ac.uk/13338/1/539199.pdf

Thesis Detection and monitoring of the autophagy response in mammalian cells using Raman spectroscopy and machine learning

Davison-Gates, Liam · 2022 · The University of Edinburgh · DOI

Full title: Detection and monitoring of the autophagy response in mammalian cells using Raman spectroscopy and machine learning

Authors: Davison-Gates, Liam

Year: 2022

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/39251

Thesis Use of on-line metabolomics for bioprocess monitoring

Cortada Garcia, Joan · 2022 · The University of Edinburgh · DOI

Full title: Use of on-line metabolomics for bioprocess monitoring

Authors: Cortada Garcia, Joan

Year: 2022

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/39209

Thesis Sustainable cultivation and harvesting strategy for Spirulina biorefinery: integrating internet-of-things monitoring and continuous cultivation

Lim, Hooi Ren · 2024 · University of Nottingham · DOI

Full title: Sustainable cultivation and harvesting strategy for Spirulina biorefinery: integrating internet-of-things monitoring and continuous cultivation

Authors: Lim, Hooi Ren

Year: 2024

Venue: University of Nottingham

DOI: https://eprints.nottingham.ac.uk/77945/1/Lim%20Hooi%20Ren%20-%2020323109%20-%20Thesis.pdf

Thesis Metabolomics-driven investigation of novel growth inhibitors in CHO cell bioprocessing

Johnston, Luke · 2025 · The University of Edinburgh · DOI

Full title: Metabolomics-driven investigation of novel growth inhibitors in CHO cell bioprocessing

Authors: Johnston, Luke

Year: 2025

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/44239

Thesis Ultrasonic measurements and machine learning methods to monitor industrial processes

Bowler, Alexander · 2023 · University of Nottingham · DOI

Full title: Ultrasonic measurements and machine learning methods to monitor industrial processes

Authors: Bowler, Alexander

Year: 2023

Venue: University of Nottingham

DOI: https://eprints.nottingham.ac.uk/76333/1/Revised%20thesis%20-%20280923.pdf

Thesis The Digitization of Wine Fermentation

Nelson, James · 2023 · University of California, Davis · DOI

Full title: The Digitization of Wine Fermentation

Authors: Nelson, James

Year: 2023

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/878621p3

Thesis Proof-of-concept analytical instrument for label-free optical deconvolution of protein species in a mixture

Hales, John E.; Aoudjane, Samir; Aeppli, Gabriel et al. · 2021 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Proof-of-concept analytical instrument for label-free optical deconvolution of protein species in a mixture

Authors: Hales, John E.; Aoudjane, Samir; Aeppli, Gabriel; Dalby, Paul A.

Year: 2021

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/177182

Thesis Data Reconciliation of Concentration Estimates from Mid-Infrared and Dielectric Spectral Measurements for Improved On-Line Monitoring of Bioprocesses

Dabros, Michal; Amrhein, Michael; Bonvin, Dominique et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Data Reconciliation of Concentration Estimates from Mid-Infrared and Dielectric Spectral Measurements for Improved On-Line Monitoring of Bioprocesses

Authors: Dabros, Michal; Amrhein, Michael; Bonvin, Dominique; Marison, Ian W.; von Stockar, Urs

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/58352

Thesis Robust model development and enhancement techniques for improved on-line spectroscopic monitoring of bioprocesses

Dabros, Michal · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Robust model development and enhancement techniques for improved on-line spectroscopic monitoring of bioprocesses

Authors: Dabros, Michal

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/15562

Thesis On-Line Recalibration of Spectral Measurements Using Metabolite Injections and Dynamic Orthogonal Projection

Dabros, Michal; Amrhein, Michael; Gujral, Paman et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-Line Recalibration of Spectral Measurements Using Metabolite Injections and Dynamic Orthogonal Projection

Authors: Dabros, Michal; Amrhein, Michael; Gujral, Paman; von Stockar, Urs

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7458

Thesis One-line monitoring, state and parameter estimation, adaptive/computer control and dynamic optimization of a continuous bioreactor

Thatipamala, Ramakrishnaiah · 2008 · University of Saskatchewan - HARVEST · DOI

Full title: One-line monitoring, state and parameter estimation, adaptive/computer control and dynamic optimization of a continuous bioreactor

Authors: Thatipamala, Ramakrishnaiah

Year: 2008

Venue: University of Saskatchewan - HARVEST

DOI: http://hdl.handle.net/10388/etd-09232008-091731

Thesis Drift Correction in Multivariate Calibration Models Using On-line Reference Measurements

Gujral, Paman; Amrhein, Michael; Bonvin, Dominique · 2008 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Drift Correction in Multivariate Calibration Models Using On-line Reference Measurements

Authors: Gujral, Paman; Amrhein, Michael; Bonvin, Dominique

Year: 2008

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/27832

Thesis On-line monitoring of nine different batch cultures of E-coli by mid-infrared spectroscopy, using a single spectra library for calibration

Schenk, Jonas; Viscasillas, Carla; Marison, Ian W. et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-line monitoring of nine different batch cultures of E-coli by mid-infrared spectroscopy, using a single spectra library for calibration

Authors: Schenk, Jonas; Viscasillas, Carla; Marison, Ian W.; von Stockar, Urs

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/58368

Thesis pH prediction and control in bioprocesses using mid-infrared spectroscopy

Schenk, Jonas; Marison, Ian W.; von Stockarl, Urs · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: pH prediction and control in bioprocesses using mid-infrared spectroscopy

Authors: Schenk, Jonas; Marison, Ian W.; von Stockarl, Urs

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/58366

Thesis Preferential Estimation for Uncertain Linear Systems at Steady State: Application to Filamentous Fungal Fermentation

Bodizs, Levente; Srinivasan, Bala; Bonvin, Dominique · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Preferential Estimation for Uncertain Linear Systems at Steady State: Application to Filamentous Fungal Fermentation

Authors: Bodizs, Levente; Srinivasan, Bala; Bonvin, Dominique

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/212723

Thesis Online calorimetry as a technique for process monitoring and control in biotechnology

vonStockar, Urs; Duboc, Philippe; Menoud, Laurent et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Online calorimetry as a technique for process monitoring and control in biotechnology

Authors: vonStockar, Urs; Duboc, Philippe; Menoud, Laurent; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226013

Thesis Mid-infrared spectroscopic monitoring of animal cell culture bioreactor processes

Rhiel, M.; Ziegler, T.; Ducommun, P. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Mid-infrared spectroscopic monitoring of animal cell culture bioreactor processes

Authors: Rhiel, M.; Ziegler, T.; Ducommun, P.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226036

Thesis Comprehensive in-situ Bioreactor Monitoring and Control Based on a Mid-Infrared Spectroscopic Sensor System

Rhiel, M.; Cannizzaro, C.; Valentinotti, S. et al. · 2004 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Comprehensive in-situ Bioreactor Monitoring and Control Based on a Mid-Infrared Spectroscopic Sensor System

Authors: Rhiel, M.; Cannizzaro, C.; Valentinotti, S.; Marison, I.; von Stockar, U.

Year: 2004

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/175516

Thesis Indirect biomass determination in case of non-constant metabolic rates

Ducommun, P.; Ziegler, T.; Rhiel, M. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Indirect biomass determination in case of non-constant metabolic rates

Authors: Ducommun, P.; Ziegler, T.; Rhiel, M.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226037

Thesis Kinetic Modeling of Dissolution and Crystallization of Batch Reactions with in Situ Spectroscopic Measurements

Hsieh, Chun · 2013 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Kinetic Modeling of Dissolution and Crystallization of Batch Reactions with in Situ Spectroscopic Measurements

Authors: Hsieh, Chun

Year: 2013

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/92451

Thesis Large-scale calorimetry and biotechnology

Von Stockar, U.; Marison, I. W. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Large-scale calorimetry and biotechnology

Authors: Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/225961

Thesis Anaerobic calorimetry of the growth of Lactobacillus helveticus using a highly sensitive bio-RCl

Liu, J. S.; Marison, I. W.; Von Stockar, U. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Anaerobic calorimetry of the growth of Lactobacillus helveticus using a highly sensitive bio-RCl

Authors: Liu, J. S.; Marison, I. W.; Von Stockar, U.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226043

Thesis A new method for on-line measurement of the volumetric oxygen uptake rate in membrane aerated animal cell cultures

Ducommun, P.; Ruffieux, P. A.; Furter, M. P. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A new method for on-line measurement of the volumetric oxygen uptake rate in membrane aerated animal cell cultures

Authors: Ducommun, P.; Ruffieux, P. A.; Furter, M. P.; Marison, I.; von Stockar, U.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226045

Thesis On-line monitoring of Phaffia rhodozyma fed-batch process with in situ dispersive raman spectroscopy

Cannizzaro, Christopher; Rhiel, Martin; Marison, Ian et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-line monitoring of Phaffia rhodozyma fed-batch process with in situ dispersive raman spectroscopy

Authors: Cannizzaro, Christopher; Rhiel, Martin; Marison, Ian; von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226086

Thesis On-line determination of animal cell concentration in two industrial high-density culture processes by dielectric spectroscopy

Ducommun, P.; Kadouri, A.; Von Stockar, U. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-line determination of animal cell concentration in two industrial high-density culture processes by dielectric spectroscopy

Authors: Ducommun, P.; Kadouri, A.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226068

Thesis Real-time in situ monitoring of freely suspended and immobilized cell cultures based on mid-infrared spectroscopic measurements

Rhiel, Martin; Ducommun, Paul; Bolzonella, Ivan et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Real-time in situ monitoring of freely suspended and immobilized cell cultures based on mid-infrared spectroscopic measurements

Authors: Rhiel, Martin; Ducommun, Paul; Bolzonella, Ivan; Marison, Ian; Von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226062

Thesis All-in-one bioprocess monitoring with a mid-IR spectroscopic sensor

Rhiel, Martin; Cannizzaro, Christopher; Marison, Ian et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: All-in-one bioprocess monitoring with a mid-IR spectroscopic sensor

Authors: Rhiel, Martin; Cannizzaro, Christopher; Marison, Ian; von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226049

Thesis On-line stoichiometry and identification of metabolic state under dynamic process conditions

Herwig, Christoph; Marison, Ian; Von Stockar, Urs · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-line stoichiometry and identification of metabolic state under dynamic process conditions

Authors: Herwig, Christoph; Marison, Ian; Von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226052

Thesis The development and characterization of a high resolution bio-reaction calorimeter for weakly exothermic cultures

Garcia-Payo, M. C.; Ampuero, S.; Liu, J. S. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: The development and characterization of a high resolution bio-reaction calorimeter for weakly exothermic cultures

Authors: Garcia-Payo, M. C.; Ampuero, S.; Liu, J. S.; Marison, I. W.; von Stockar, U.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226080

Thesis Experimental versus simulated calibration mdels for in situ FTIR monitoring of bioprocesses

Valentinotti, Sergio; Kornmann, Henri; Rhiel, Martin H. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Experimental versus simulated calibration mdels for in situ FTIR monitoring of bioprocesses

Authors: Valentinotti, Sergio; Kornmann, Henri; Rhiel, Martin H.; von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226096

Thesis On-line biomass monitoring with scanning dielectric spectroscopy

Cannizzaro, Christopher M.; Valentinotti, Sergio; Marison, Ian W. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-line biomass monitoring with scanning dielectric spectroscopy

Authors: Cannizzaro, Christopher M.; Valentinotti, Sergio; Marison, Ian W.; von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226087

Thesis Characterization of Fibra-Cel® packed-bed bioreactors for the culture of CHO cells

Meuwly, Frédéric · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Characterization of Fibra-Cel® packed-bed bioreactors for the culture of CHO cells

Authors: Meuwly, Frédéric

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/218454

Thesis Real-time update of calibration model for better monitoring of batch processes using spectroscopy

Kornmann, Henri; Valentinotti, Sergio; Marison, Ian et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Real-time update of calibration model for better monitoring of batch processes using spectroscopy

Authors: Kornmann, Henri; Valentinotti, Sergio; Marison, Ian; von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226102

Thesis Bioprocess monitoring and control using the combination of fluorescence, mid-IR, and Raman spectroscopy

Rhiel, Martin; Cannizzaro, Christopher; Valentinotti, Sergio et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Bioprocess monitoring and control using the combination of fluorescence, mid-IR, and Raman spectroscopy

Authors: Rhiel, Martin; Cannizzaro, Christopher; Valentinotti, Sergio; Marison, Ian; von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226057

Thesis Development of a large-scale biocalorimeter to monitor and control bioprocesses

Voisard, D.; Pugeaud, P.; Kumar, A. R. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Development of a large-scale biocalorimeter to monitor and control bioprocesses

Authors: Voisard, D.; Pugeaud, P.; Kumar, A. R.; Jenny, K.; Jayaraman, K.; Marison, I. W.; Von Stockar, U.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226079

Thesis Know-how and know-why in biochemical engineering

von Stockar, U.; Valentinotti, S.; Marison, I. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Know-how and know-why in biochemical engineering

Authors: von Stockar, U.; Valentinotti, S.; Marison, I.; Cannizzaro, C.; Herwig, C.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226090

Thesis The influence of correlated calibration samples on the prediction performance of multivariate models based on mid-infrared spectra of animal cell cultures

Rhiel Martin, H.; Amrhein Michael, I.; Marison Ian, W. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: The influence of correlated calibration samples on the prediction performance of multivariate models based on mid-infrared spectra of animal cell cultures

Authors: Rhiel Martin, H.; Amrhein Michael, I.; Marison Ian, W.; von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226073

Thesis ENGINEERING BIOSENSOR CELL LINES TO INVESTIGATE INTRACELLULAR IMPACTS OF MAMMALIAN BIOPROCESSES

McFarland, Kevin Stephen · 2023 · Johns Hopkins University · DOI

Full title: ENGINEERING BIOSENSOR CELL LINES TO INVESTIGATE INTRACELLULAR IMPACTS OF MAMMALIAN BIOPROCESSES

Authors: McFarland, Kevin Stephen

Year: 2023

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/68933

Thesis On-line biomass monitoring of CHO perfusion culture with scanning dielectric spectroscopy

Cannizzaro, Christopher; Guegerli, Raphael; Marison, Ian et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-line biomass monitoring of CHO perfusion culture with scanning dielectric spectroscopy

Authors: Cannizzaro, Christopher; Guegerli, Raphael; Marison, Ian; von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226088

Thesis Methodology for real-time, multianalyte monitoring of fermentations using an in-situ mid-infrared sensor

Kornmann, Henri; Rhiel, Martin; Cannizzaro, Christopher et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Methodology for real-time, multianalyte monitoring of fermentations using an in-situ mid-infrared sensor

Authors: Kornmann, Henri; Rhiel, Martin; Cannizzaro, Christopher; Marison, Ian; von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226089

Thesis Development and validation of a hybrid model for prediction of viable cell density, titer and cumulative glucose consumption in a mammalian cell culture system

Yatipanthalawa, BS; Wallace Fitzsimons, SE; Horning, T et al. · 2024 · University of Melbourne · DOI

Full title: Development and validation of a hybrid model for prediction of viable cell density, titer and cumulative glucose consumption in a mammalian cell culture system

Authors: Yatipanthalawa, BS; Wallace Fitzsimons, SE; Horning, T; Lee, YY; Gras, SL

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/345116

Thesis Automatic detection of reaction start/endpoints in chemical and biotechnological reaction systems

Corminboeuf, Grégory; Amrhein, Michael; Naef, Olivier et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Automatic detection of reaction start/endpoints in chemical and biotechnological reaction systems

Authors: Corminboeuf, Grégory; Amrhein, Michael; Naef, Olivier; Voirin, Pascale; Vanoli, Ennio; Aebischer, Jean-Nicolas; Crelier, Simon

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/228822

Thesis Biomass performance : monitoring and control in bio-pharmaceutical production

Neeleman, R. · 2002 · Wageningen University & Research · DOI

Full title: Biomass performance : monitoring and control in bio-pharmaceutical production

Authors: Neeleman, R.

Year: 2002

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/biomass-performance-monitoring-and-control-in-bio-pharmaceutical-

Thesis Advanced monitoring and control in biopharmaceutical production

Soons, Z.I.T.A. · 2008 · Wageningen University & Research · DOI

Full title: Advanced monitoring and control in biopharmaceutical production

Authors: Soons, Z.I.T.A.

Year: 2008

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/advanced-monitoring-and-control-in-biopharmaceutical-production

Thesis Decoding the gut’s volatilome : novel in-vitro approaches to understand diet-microbiota dynamics

Dell'Olio, Andrea · 2025 · Wageningen University & Research · DOI

Full title: Decoding the gut’s volatilome : novel in-vitro approaches to understand diet-microbiota dynamics

Authors: Dell'Olio, Andrea

Year: 2025

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/decoding-the-guts-volatilome-novel-in-vitro-approaches-to-underst

Thesis Single-objective robust optimisation in bioprocessing with conformalised quantile regression as interval-based surrogate models

Pham, TD; Bassett, R; Aickelin, U · 2025 · University of Melbourne · DOI

Full title: Single-objective robust optimisation in bioprocessing with conformalised quantile regression as interval-based surrogate models

Authors: Pham, TD; Bassett, R; Aickelin, U

Year: 2025

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/361033

Thesis On-line monitoring and control of animal-cell cultures

van der Pol, J.J. · 1996 · Wageningen University & Research · DOI

Full title: On-line monitoring and control of animal-cell cultures

Authors: van der Pol, J.J.

Year: 1996

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/on-line-monitoring-and-control-of-animal-cell-cultures

Thesis Transcriptomic profiling as a tool to characterize CHO cell processes

Al Sayyari, Abdulaziz Abdullah · 2018 · Wageningen University & Research · DOI

Full title: Transcriptomic profiling as a tool to characterize CHO cell processes

Authors: Al Sayyari, Abdulaziz Abdullah

Year: 2018

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/transcriptomic-profiling-as-a-tool-to-characterize-cho-cell-proce

Thesis Software sensors as a tool for optimization of animal-cell cultures

Dorresteijn, R.C. · 1997 · Wageningen University & Research · DOI

Full title: Software sensors as a tool for optimization of animal-cell cultures

Authors: Dorresteijn, R.C.

Year: 1997

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/software-sensors-as-a-tool-for-optimization-of-animal-cell-cultur

Thesis Developing an Automated System for Yeast Culture Cultivation and Control using Flow Cytometry

Magnusson, Sara · 2023 · Lund University Student Papers · DOI

Full title: Developing an Automated System for Yeast Culture Cultivation and Control using Flow Cytometry

Authors: Magnusson, Sara

Year: 2023

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9139429

Thesis Robust spectral estimation for speed of sound with phase shift correction applied online in yeast fermentation processes

Hussein, Walid B.; Hussein, Mohamed A.; Becker, Thomas · 2012 · Technical University of Munich (TUM) · DOI

Full title: Robust spectral estimation for speed of sound with phase shift correction applied online in yeast fermentation processes

Authors: Hussein, Walid B.;Hussein, Mohamed A.;Becker, Thomas

Year: 2012

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1377128

Thesis Fuzzy logic control and soft sensing applications in food and beverage processes

Birle, S.; Hussein, M. A.; Becker, T. · 2013 · Technical University of Munich (TUM) · DOI

Full title: Fuzzy logic control and soft sensing applications in food and beverage processes

Authors: Birle, S.;Hussein, M. A.;Becker, T.

Year: 2013

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1377099

Thesis On-line yeast propagation process monitoring and control using an intelligent automatic control system

Birle, Stephan; Hussein, Mohamed Ahmed; Becker, Thomas · 2015 · Technical University of Munich (TUM) · DOI

Full title: On-line yeast propagation process monitoring and control using an intelligent automatic control system

Authors: Birle, Stephan;Hussein, Mohamed Ahmed;Becker, Thomas

Year: 2015

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1377100

Thesis Probing Control of a Fedbatch Fermentation. Simulation and Implementation in ABB Industrial IT

Li, Tory · 2004 · Lund University Student Papers · DOI

Full title: Probing Control of a Fedbatch Fermentation. Simulation and Implementation in ABB Industrial IT

Authors: Li, Tory

Year: 2004

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/8848000

Thesis Time-of-flight prediction for fermentation process monitoring

Hoche, Sven; Hussein, Walid B.; Hussein, Mohamed A. et al. · 2011 · Technical University of Munich (TUM) · DOI

Full title: Time-of-flight prediction for fermentation process monitoring

Authors: Hoche, Sven;Hussein, Walid B.;Hussein, Mohamed A.;Becker, Thomas

Year: 2011

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1377119

Thesis Raman activated cell sorting and counting in continuous flow

McIlvenna, David · 2015 · University of Glasgow · DOI

Full title: Raman activated cell sorting and counting in continuous flow

Authors: McIlvenna, David

Year: 2015

Venue: University of Glasgow

DOI: oai:theses.gla.ac.uk:6333

Thesis Biomass estimation in Pichia pastoris cultures by combined single-wavelength fluorescence measurements

Brunner, Vincent; Hussein, Mohamed; Becker, Thomas · 2016 · Technical University of Munich (TUM) · DOI

Full title: Biomass estimation in Pichia pastoris cultures by combined single-wavelength fluorescence measurements

Authors: Brunner, Vincent;Hussein, Mohamed;Becker, Thomas

Year: 2016

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1377103

Thesis Effects of yeast and maltose concentration on ultrasonic velocity and attenuation coefficient and its application for process monitoring

Geier, Dominik; Heermann, Katrin; Hussein, Mohamed et al. · 2014 · Technical University of Munich (TUM) · DOI

Full title: Effects of yeast and maltose concentration on ultrasonic velocity and attenuation coefficient and its application for process monitoring

Authors: Geier, Dominik;Heermann, Katrin;Hussein, Mohamed;Becker, Thomas

Year: 2014

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1377113

Thesis Ultrasonic sensor for predicting sugar concentration using multivariate calibration

Krause, D.; Hussein, W. B.; Hussein, M. A. et al. · 2014 · Technical University of Munich (TUM) · DOI

Full title: Ultrasonic sensor for predicting sugar concentration using multivariate calibration

Authors: Krause, D.;Hussein, W. B.;Hussein, M. A.;Becker, T.

Year: 2014

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1377225

Thesis Bioprocess monitoring and control via adaptive sensor calibration

Krause, Daniel; Birle, Stephan; Hussein, Mohamed A. et al. · 2011 · Technical University of Munich (TUM) · DOI

Full title: Bioprocess monitoring and control via adaptive sensor calibration

Authors: Krause, Daniel;Birle, Stephan;Hussein, Mohamed A.;Becker, Thomas

Year: 2011

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1377224

Thesis Development of a real-time algal biomass and health optical sensor

Ferrell-Carretey, Elliot, author; Reardon, Ken F., advisor; Dandy, David, committee member et al. · 2025 · Colorado State University · DOI

Full title: Development of a real-time algal biomass and health optical sensor

Authors: Ferrell-Carretey, Elliot, author; Reardon, Ken F., advisor; Dandy, David, committee member; Henry, Chuck, committee member

Year: 2025

Venue: Colorado State University

DOI: https://hdl.handle.net/10217/241813

Thesis Simultaneous real-time estimation of maximum substrate uptake capacity and yield coefficient in induced microbial cultures

Müller, Don Fabian; Wibbing, Daniel; Herwig, Christoph et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Simultaneous real-time estimation of maximum substrate uptake capacity and yield coefficient in induced microbial cultures

Authors: Müller, Don Fabian; Wibbing, Daniel; Herwig, Christoph; Kager, Julian; id_orcid 0000-0001-7274-6678

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0c248b7d-bf0c-43c4-a5b3-532cb4003c87

Thesis A probabilistic model-based soft sensor to monitor lactic acid bacteria fermentations

Spann, Robert; id_orcid 0000-0003-1223-2805; Roca, Christophe et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: A probabilistic model-based soft sensor to monitor lactic acid bacteria fermentations

Authors: Spann, Robert; id_orcid 0000-0003-1223-2805; Roca, Christophe; Kold, David; Eliasson Lantz, Anna; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Sin, Gürkan; id_orcid 0000-0003-0513-4502

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/06a320b8-2a66-40cf-9b98-d296481ec8b7

Thesis Comparison of noninvasive, in-situ and external monitoring of microbial growth in fed-batch cultivations in Corynebacterium glutamicum

Lira-Parada, Pedro A.; Tuveri, Andrea; Seibold, Gerd M. et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Comparison of noninvasive, in-situ and external monitoring of microbial growth in fed-batch cultivations in Corynebacterium glutamicum

Authors: Lira-Parada, Pedro A.; Tuveri, Andrea; Seibold, Gerd M.; id_orcid 0000-0002-9823-8134; Bar, Nadav

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2af65589-a5cf-48ba-a9cb-f024e8ea03d1

Thesis Hybrid Modelling for Enhanced Bioreactor Performance

Thaysen, Mads · 2006 · Technical University of Denmark (DTU) · DOI

Full title: Hybrid Modelling for Enhanced Bioreactor Performance

Authors: Thaysen, Mads

Year: 2006

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0bf63473-e65c-4330-b41d-de9efc18fe1c

Thesis Novel strategies for control of fermentation processes

Mears, Lisa; Stocks, Stuart; Sin, Gürkan et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Novel strategies for control of fermentation processes

Authors: Mears, Lisa; Stocks, Stuart; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Villez, Kris

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0a72255f-95c0-49d4-a1a0-94bd2bf871b1

Thesis PAT tools for fermentation processes

Gernaey, Krist; id_orcid 0000-0002-0364-1773 · 2012 · Technical University of Denmark (DTU) · DOI

Full title: PAT tools for fermentation processes

Authors: Gernaey, Krist; id_orcid 0000-0002-0364-1773

Year: 2012

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/34b57d31-6333-4953-a068-52705b8ef865

Thesis Monitoring yeast fermentations by nonlinear infrared technology and chemometrics-understanding process correlations and indirect predictions

Pontius, Katrin; Junicke, Helena; id_orcid 0000-0002-2513-2486 et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Monitoring yeast fermentations by nonlinear infrared technology and chemometrics-understanding process correlations and indirect predictions

Authors: Pontius, Katrin; Junicke, Helena; id_orcid 0000-0002-2513-2486; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Bevilacqua, Marta

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2fba9be3-176c-43ae-96fd-694952fade50

Thesis Towards a digital twin: a hybrid data‐driven and mechanistic digital shadow to forecast the evolution of lignocellulosic fermentation

Lopez, Pau Cabañeros; Udugama, Isuru A.; Thomsen, Sune Tjalfe et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Towards a digital twin: a hybrid data‐driven and mechanistic digital shadow to forecast the evolution of lignocellulosic fermentation

Authors: Lopez, Pau Cabañeros; Udugama, Isuru A.; Thomsen, Sune Tjalfe; Roslander, Christian; Junicke, Helena; id_orcid 0000-0002-2513-2486; Mauricio‐Iglesias, Miguel; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2c30c0c9-78cc-47a9-a575-7eff034581f2

Thesis Mechanistic Modelling for Risk-Based Monitoring of Lactic Acid Bacteria Cultivations

Spann, Robert; id_orcid 0000-0003-1223-2805 · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Mechanistic Modelling for Risk-Based Monitoring of Lactic Acid Bacteria Cultivations

Authors: Spann, Robert; id_orcid 0000-0003-1223-2805

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2c6994fa-1b56-43d2-b037-9a4a2ff8321c

Thesis Towards Digitalization in Bio-Manufacturing Operations: A Survey on Application of Big Data and Digital Twin Concepts in Denmark

A. Udugama, Isuru; Öner, Merve; Lopez, Pau C. et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Towards Digitalization in Bio-Manufacturing Operations: A Survey on Application of Big Data and Digital Twin Concepts in Denmark

Authors: A. Udugama, Isuru; Öner, Merve; Lopez, Pau C.; Beenfeldt, Christan; Bayer, Christoph; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Sin, Gürkan; id_orcid 0000-0003-0513-4502

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3b235ea5-e6fe-4ae1-ab77-68ef017d8a55

Thesis A “real‐time” sequential hybrid modeling approach to monitor and forecast key process variables in ethanol fermentation using lignocellulosic feedstocks

Lopez, Pau Cabañeros; Udugama, Isuru; Thomsen, Sune Tjalfe et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: A “real‐time” sequential hybrid modeling approach to monitor and forecast key process variables in ethanol fermentation using lignocellulosic feedstocks

Authors: Lopez, Pau Cabañeros; Udugama, Isuru; Thomsen, Sune Tjalfe; Roslander, Christian; Junicke, Helena; id_orcid 0000-0002-2513-2486; Mauricio-Iglesias, Miguel; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3a162256-b10e-48e0-89bf-1d67d41c02b3

Thesis Implementation of real-time incremental learning for ensemble hybrid model prediction in pilot scale bubble column aeration

Jul-Rasmussen, Peter; Stevnsborg, Mads; Liang, Xiaodong et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Implementation of real-time incremental learning for ensemble hybrid model prediction in pilot scale bubble column aeration

Authors: Jul-Rasmussen, Peter; Stevnsborg, Mads; Liang, Xiaodong; id_orcid 0000-0002-2007-546X; Huusom, Jakob Kjøbsted; id_orcid 0000-0002-1367-7235

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3a281c09-30fc-4659-9dc6-33d64f78b7b8

Thesis An all-in-one state-observer for protein refolding reactions using particle filters and delayed measurements

Pauk, Jan Niklas; Igwe, Chika Linda; Herwig, Christoph et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: An all-in-one state-observer for protein refolding reactions using particle filters and delayed measurements

Authors: Pauk, Jan Niklas; Igwe, Chika Linda; Herwig, Christoph; Kager, Julian; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/43b69497-a5a8-42c2-a0b3-6c75473918f9

Thesis Accelerating Vaccine Manufacturing Development through Model-Based Approaches: Current Advances and Future Opportunities

Ramin, Elham; id_orcid 0000-0002-2301-7492; Cardillo, Antonio Gaetano et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Accelerating Vaccine Manufacturing Development through Model-Based Approaches: Current Advances and Future Opportunities

Authors: Ramin, Elham; id_orcid 0000-0002-2301-7492; Cardillo, Antonio Gaetano; Liebers, Reinhard; Schmölder, Johannes; von Lieres, Eric; Van Molle, Wim; Niebel, Bastian; Natalis, Laurent; Meln, Irina; Perea-Vélez, Mónica; Clénet, Didier; Jørgensen, John Bagterp; id_orcid 0000-0001-9799-2808; Nilsson, Bernt; Bracewell, Daniel G.; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/438c59d4-d768-4ed9-8894-06993d050d91

Thesis Hybrid machine-learning for dynamic plant-wide biomanufacturing

Shahhoseyni, Shabnam; Chakraborty, Arijit; Boskabadi, Mohammad Reza et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Hybrid machine-learning for dynamic plant-wide biomanufacturing

Authors: Shahhoseyni, Shabnam; Chakraborty, Arijit; Boskabadi, Mohammad Reza; Venkatasubramanian, Venkat; Mansouri, Seyed Soheil; id_orcid 0000-0002-0924-4947

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/31b83b7d-b842-484f-9d03-65c948d398c6

Thesis Model Predictive Control of dissolved oxygen level in an intermittent fed-batch process – Simulation & Application

Pably, P.; Huusom, J. K.; id_orcid 0000-0002-1367-7235 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Model Predictive Control of dissolved oxygen level in an intermittent fed-batch process – Simulation & Application

Authors: Pably, P.; Huusom, J. K.; id_orcid 0000-0002-1367-7235; Kager, J.; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/67f0a177-939b-4449-92b5-edae7e087c69

Thesis Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Martínez-Monge, I.; Martínez, C.; Decker, M. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Authors: Martínez-Monge, I.; Martínez, C.; Decker, M.; Udugama, I. A.; Marín de Mas, I.; Gernaey, K. V.; id_orcid 0000-0002-0364-1773; Nielsen, L. K.

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3b1685d4-5ab9-4737-b414-d28fecf9b9eb

Thesis Raw material quality assessment approaches comparison in pectin production

Caroço, Ricardo F.; Bevilacqua, Marta; Armagan, Ibrahim et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Raw material quality assessment approaches comparison in pectin production

Authors: Caroço, Ricardo F.; Bevilacqua, Marta; Armagan, Ibrahim; Santacoloma, Paloma A.; Abildskov, Jens; id_orcid 0000-0003-1187-8778; Skov, Thomas; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/72ad7018-cbc0-4ce1-861b-9224a96ed072

Thesis Determining the linear correlation between dielectric spectroscopy and viable biomass concentration in filamentous fungal fermentations

Magnússon, Atli; id_orcid 0000-0003-4060-2965; Pajander, Jari et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Determining the linear correlation between dielectric spectroscopy and viable biomass concentration in filamentous fungal fermentations

Authors: Magnússon, Atli; id_orcid 0000-0003-4060-2965; Pajander, Jari; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Stocks, Stuart

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/341dab79-38a5-4b5b-8d46-857102473ea9

Thesis Automated Electrochemical Glucose Biosensor Platform as an Efficient Tool Toward On-Line Fermentation Monitoring:Novel Application Approaches and Insights

Pontius, Katrin; Semenova, Daria; Silina, Yuliya E. et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Automated Electrochemical Glucose Biosensor Platform as an Efficient Tool Toward On-Line Fermentation Monitoring:Novel Application Approaches and Insights

Authors: Pontius, Katrin; Semenova, Daria; Silina, Yuliya E.; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Junicke, Helena; id_orcid 0000-0002-2513-2486

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/715e756f-cf70-460c-b319-b3014dd5729d

Thesis Potential of predictive model-based dissolved oxygen control for intermittent fed-batch processes

Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Potential of predictive model-based dissolved oxygen control for intermittent fed-batch processes

Authors: Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235; Kager, Julian; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/672b1410-685c-430d-9a82-cd4a33c61d66

Thesis Design and development of electrochemical polymer-based lab-on-a-disc devices for biological applications

Sanger, Kuldeep · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Design and development of electrochemical polymer-based lab-on-a-disc devices for biological applications

Authors: Sanger, Kuldeep

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/6d310172-65be-4d90-a18d-66fbedc1d77c

Thesis Advanced modeling of industrial-scale fermentation process for antibiotic production

Magnusson, Atli Freyr; id_orcid 0000-0003-4060-2965 · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Advanced modeling of industrial-scale fermentation process for antibiotic production

Authors: Magnusson, Atli Freyr; id_orcid 0000-0003-4060-2965

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5ec6b30f-579e-465d-b28a-5223114e5c8d

Thesis Optics miniaturization strategy for demanding Raman spectroscopy applications

Ilchenko, Oleksii; id_orcid 0000-0002-2150-895X; Pilhun, Yurii et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Optics miniaturization strategy for demanding Raman spectroscopy applications

Authors: Ilchenko, Oleksii; id_orcid 0000-0002-2150-895X; Pilhun, Yurii; Kutsyk, Andrii; Slobodianiuk, Denys; Goksel, Yaman; Dumont, Elodie; id_orcid 0000-0003-4798-1937; Vaut, Lukas; Mazzoni, Chiara; id_orcid 0000-0002-0988-3108; Morelli, Lidia; Boisen, Sofus; Stergiou, Konstantinos; Aulin, Yaroslav; Rindzevicius, Tomas; id_orcid 0000-0002-0712-1388; Andersen, Thomas Emil; Lassen, Mikael; Mundhada, Hemanshu; Jendresen, Christian Bille; Philipsen, Peter Alshede; Hædersdal, Merete; Boisen, Anja; id_orcid 0000-0002-9918-6567

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/65c2a878-1298-4d94-b404-fb32ae75d80d

Thesis Transforming data to information: A parallel hybrid model for real-time state estimation in lignocellulosic ethanol fermentations

Lopez, Pau Cabañeros; Udugama, Isuru A.; Thomsen, Sune Tjalfe et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Transforming data to information: A parallel hybrid model for real-time state estimation in lignocellulosic ethanol fermentations

Authors: Lopez, Pau Cabañeros; Udugama, Isuru A.; Thomsen, Sune Tjalfe; Roslander, Christian; Junicke, Helena; id_orcid 0000-0002-2513-2486; Mauricio Iglesias, Miguel; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/73a15f9b-df7c-4935-9424-e542ba4f7ab9

Thesis On-line monitoring of fermentation processes for 2G bioethanol production

Lopez, Pau Cabañeros; André Fernandes , Ricardo C.; Junicke, Helena et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: On-line monitoring of fermentation processes for 2G bioethanol production

Authors: Lopez, Pau Cabañeros; André Fernandes , Ricardo C.; Junicke, Helena; id_orcid 0000-0002-2513-2486; Mauricio-Iglesias, Miguel; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/903229bf-0b12-48a9-968b-d89c6bcbdd47

Thesis Fast measurement of phosphates and ammonium in fermentation-like media: a feasibility study

Pontius, Katrin; Praticò, Giulia; Larsen, Flemming H et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Fast measurement of phosphates and ammonium in fermentation-like media: a feasibility study

Authors: Pontius, Katrin; Praticò, Giulia; Larsen, Flemming H; Skov, Thomas; Arneborg, Nils; Eliasson Lantz, Anna; Bevilacqua, Marta

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/8a513d88-d298-4a40-82d6-707c3c58053c

Thesis In-silico process design and evaluation tool for pharmaceutical manufacturing

do Carmo Montes, Frederico da Conceicao · 2020 · Technical University of Denmark (DTU) · DOI

Full title: In-silico process design and evaluation tool for pharmaceutical manufacturing

Authors: do Carmo Montes, Frederico da Conceicao

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7cd25837-dafc-4484-b16b-af385ad1fce6

Thesis Automated compartment model development based on data from flow-following sensor devices

Bisgaard, Jonas; Tajsoleiman, Tannaz; id_orcid 0000-0001-8543-4585 et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Automated compartment model development based on data from flow-following sensor devices

Authors: Bisgaard, Jonas; Tajsoleiman, Tannaz; id_orcid 0000-0001-8543-4585; Muldbak, Monica; id_orcid 0000-0001-6368-3804; Rydal, Thomas; Rasmussen, Tue; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7871337b-69b9-4a30-a085-eff52694deb6

Thesis IR-spectroscopy and PLS modelling for advanced bio-process monitoring: simultaneous and rapid sensing of various components

Pontius, Katrin; Bevilacqua, Marta; Junicke, Helena et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: IR-spectroscopy and PLS modelling for advanced bio-process monitoring: simultaneous and rapid sensing of various components

Authors: Pontius, Katrin; Bevilacqua, Marta; Junicke, Helena; id_orcid 0000-0002-2513-2486; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/93c1f2e3-1971-4783-b94f-5b5c18c6036d

Thesis Continuous ethanol production via ultrasound-enhanced yeast sedimentation

Domingo-Félez, Carlos; Jankowska, Katarzyna; id_orcid 0000-0002-3283-0338 et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Continuous ethanol production via ultrasound-enhanced yeast sedimentation

Authors: Domingo-Félez, Carlos; Jankowska, Katarzyna; id_orcid 0000-0002-3283-0338; Skiadas, Ioannis V.; id_orcid 0000-0001-6183-4592; Woodley, John M.; id_orcid 0000-0002-7976-2483; Pinelo, Manuel; id_orcid 0000-0002-3944-6144

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9dd0dd08-655a-429c-a5bc-6186023c6c6b

Thesis Multivariate analysis of industrial scale fermentation data

Mears, Lisa; Nørregård, Rasmus; Stocks, Stuart et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Multivariate analysis of industrial scale fermentation data

Authors: Mears, Lisa; Nørregård, Rasmus; Stocks, Stuart; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Villez, Kris

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a481700c-5fd9-4857-b39c-877760461b94

Thesis A compartment model for risk-based monitoring of lactic acid bacteria cultivations

Spann, Robert; id_orcid 0000-0003-1223-2805; Gernaey, Krist V. et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: A compartment model for risk-based monitoring of lactic acid bacteria cultivations

Authors: Spann, Robert; id_orcid 0000-0003-1223-2805; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Sin, Gürkan; id_orcid 0000-0003-0513-4502

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b48fccb9-5c2b-4d67-9980-a437405c4249

Thesis Harvest time prediction for batch processes

Spooner, Max Peter; Kold, David; Kulahci, Murat et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Harvest time prediction for batch processes

Authors: Spooner, Max Peter; Kold, David; Kulahci, Murat; id_orcid 0000-0003-4222-9631

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a5a9f2c7-da9c-4a06-8c72-3a364d5bb0e5

Thesis Model-based Monitoring and Optimization of a Bio-based Process

Fernandes Caroço, Ricardo · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Model-based Monitoring and Optimization of a Bio-based Process

Authors: Fernandes Caroço, Ricardo

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9e5fd38b-9431-4535-bbc4-fdb7b96812c5

Thesis A Semi-supervised Soft-sensor of Just-in-time Learning With Structure Entropy Clustering and Applications for Industrial Processes Monitoring

Li, Dong; Liu, Yiqi; id_orcid 0000-0001-8911-727X et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: A Semi-supervised Soft-sensor of Just-in-time Learning With Structure Entropy Clustering and Applications for Industrial Processes Monitoring

Authors: Li, Dong; Liu, Yiqi; id_orcid 0000-0001-8911-727X; Huang, Daoping; Xu, Chong

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a070087c-170b-4c8d-8ac3-35eb49159eb8

Thesis Design and Application of an Electrochemical Sensor for Ammonium Monitoring in Bioprocesses

Hasanzadeh, Aliyeh; id_orcid 0000-0001-7505-7317; Junicke, Helena et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Design and Application of an Electrochemical Sensor for Ammonium Monitoring in Bioprocesses

Authors: Hasanzadeh, Aliyeh; id_orcid 0000-0001-7505-7317; Junicke, Helena; id_orcid 0000-0002-2513-2486; Dimaki, Maria; id_orcid 0000-0001-5037-2388; Semenova, Daria; Kilstrup, Mogens; id_orcid 0000-0002-3900-723X; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a15773cf-19f1-4a40-8168-2c0e66261a3c

Thesis Development and Application of a Novel Free-floating Sensor Device for Bioprocess Optimization

Bisgaard, Jonas · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Development and Application of a Novel Free-floating Sensor Device for Bioprocess Optimization

Authors: Bisgaard, Jonas

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a5765731-0e3a-4e97-942e-0b93dbe22c31

Thesis Microalgal process-monitoring based on high-selectivity spectroscopy tools: status and future perspectives

Podevin, Michael Paul Ambrose; Fotidis, Ioannis; id_orcid 0000-0003-4587-3617 et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Microalgal process-monitoring based on high-selectivity spectroscopy tools: status and future perspectives

Authors: Podevin, Michael Paul Ambrose; Fotidis, Ioannis; id_orcid 0000-0003-4587-3617; Angelidaki, Irini; id_orcid 0000-0002-6357-578X

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ab1769f0-b7f3-4970-87bc-67fead269c6d

Thesis Development of an on-line state estimator for fed-batch filamentous fungal fermentations

Mears, Lisa; Stocks, Stuart M.; Albæk, Mads O. et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Development of an on-line state estimator for fed-batch filamentous fungal fermentations

Authors: Mears, Lisa; Stocks, Stuart M.; Albæk, Mads O.; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist; id_orcid 0000-0002-0364-1773

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b422bebe-f96c-4e37-a349-618f0c11d541

Thesis Fourier Transform Infrared Spectroscopy Tracking of Fermentation of Oat and Pea Bases for Yoghurt-Type Products

Greulich, Olivia; Duedahl-Olesen, Lene; id_orcid 0000-0002-3162-0101 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Fourier Transform Infrared Spectroscopy Tracking of Fermentation of Oat and Pea Bases for Yoghurt-Type Products

Authors: Greulich, Olivia; Duedahl-Olesen, Lene; id_orcid 0000-0002-3162-0101; Mikkelsen, Mette Skau; Smedsgaard, Jørn; Bang-Berthelsen, Claus Heiner; id_orcid 0000-0003-4541-2538

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b021d179-47d4-4a12-bb2e-fbc232ed7ca5

Thesis Hybrid Modelling Strategies for Development of Digital Twins

Nielsen, Rasmus Fjordbak; id_orcid 0000-0002-3830-8743 · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Hybrid Modelling Strategies for Development of Digital Twins

Authors: Nielsen, Rasmus Fjordbak; id_orcid 0000-0002-3830-8743

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b4ca3aca-4ca7-4189-91f5-d5bef44c8f43

Thesis Identifying Drivers of Downstream Yield Variability Using Integrated Process Models: An Application to API Manufacturing

Overgaard, Tobias; Bertran, Maria Ona; Jørgensen, John Bagterp et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Identifying Drivers of Downstream Yield Variability Using Integrated Process Models: An Application to API Manufacturing

Authors: Overgaard, Tobias; Bertran, Maria Ona; Jørgensen, John Bagterp; id_orcid 0000-0001-9799-2808; Nielsen, Bo Friis; id_orcid 0000-0001-9146-9733

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c4296fd2-3123-42e0-8e21-f09af0e5990b

Thesis Monitoring of Bioprocesses. Opportunities and challenges: Opportunities and Challenges

Pontius, Katrin · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Monitoring of Bioprocesses. Opportunities and challenges: Opportunities and Challenges

Authors: Pontius, Katrin

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/aa572dad-0089-4493-8034-c45b878839b8

Thesis Hybrid Modeling for On-Line Fermentation Optimization and Scale-Up:A Review

Albino, Mariana; Gargalo, Carina L.; id_orcid 0000-0002-8740-9591 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Hybrid Modeling for On-Line Fermentation Optimization and Scale-Up:A Review

Authors: Albino, Mariana; Gargalo, Carina L.; id_orcid 0000-0002-8740-9591; Nadal-Rey, Gisela; Albæk, Mads O.; Krühne, Ulrich; id_orcid 0000-0001-7774-7442; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/da2224b1-251a-47ea-abc0-1b523e3fb360

Thesis Application of a Mechanistic Model as a Tool for On-line Monitoring of Pilot Scale Filamentous Fungal Fermentation Processes - The Importance of Evaporation Effects:Mechanistic model for pilot scale monitoring

Mears, Lisa; Stocks, Stuart M.; Albæk, Mads Orla et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Application of a Mechanistic Model as a Tool for On-line Monitoring of Pilot Scale Filamentous Fungal Fermentation Processes - The Importance of Evaporation Effects:Mechanistic model for pilot scale monitoring

Authors: Mears, Lisa; Stocks, Stuart M.; Albæk, Mads Orla; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c64235e7-3d2e-4645-8c15-c5818953a8be

Thesis Methods and tools for the statistical data analysis of large datasets collected from bio-based manufacturing processes

Spooner, Max Peter · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Methods and tools for the statistical data analysis of large datasets collected from bio-based manufacturing processes

Authors: Spooner, Max Peter

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c044b23c-a1c1-4a9c-a2cd-bac25ea815a4

Thesis Modernizing non-classical protein crystallization through industry 4.0: Advanced monitoring and modelling utilizing process analytical technology

Jul-Jørgensen, I.; id_orcid 0000-0003-1335-3772; Oliver, R. et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Modernizing non-classical protein crystallization through industry 4.0: Advanced monitoring and modelling utilizing process analytical technology

Authors: Jul-Jørgensen, I.; id_orcid 0000-0003-1335-3772; Oliver, R.; Gernaey, K. V.; id_orcid 0000-0002-0364-1773; Hundahl, C. A.

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b1a4c697-bd81-42c2-8b15-51ecb96da942

Thesis Artificial neural network associated to UV/Vis spectroscopy for monitoring bioreactions in biopharmaceutical processes

Takahashi, Maria Beatriz [UNESP]; Leme, Jaci; Caricati, Celso Pereira et al. · 2015 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Artificial neural network associated to UV/Vis spectroscopy for monitoring bioreactions in biopharmaceutical processes

Authors: Takahashi, Maria Beatriz [UNESP]; Leme, Jaci; Caricati, Celso Pereira; Tonso, Aldo; Nuñez, Eutimio Gustavo Fernández [UNESP]; Rocha, José Celso [UNESP]

Year: 2015

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://hdl.handle.net/11449/126758

Thesis Small Sensors Go Big: Towards High-Resolution Monitoring of Industrial Fermentations

Junicke, Helena; id_orcid 0000-0002-2513-2486; Semenova, Daria et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Small Sensors Go Big: Towards High-Resolution Monitoring of Industrial Fermentations

Authors: Junicke, Helena; id_orcid 0000-0002-2513-2486; Semenova, Daria; Silina, Yuliya; Koch, Markus; Flores-Alsina, Xavier; id_orcid 0000-0002-9310-0240; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d358e5b6-7cf4-4d40-8d5a-f74afe287730

Thesis Raman spectroscopy and one-dimensional convolutional neural network modeling as a real-time monitoring tool for in vitro transaminase-catalyzed synthesis of a pharmaceutically relevant amine precursor

Madsen, Julie Østerby; Topalian, Sebastian Olivier Nymann; id_orcid 0000-0002-2339-2073 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Raman spectroscopy and one-dimensional convolutional neural network modeling as a real-time monitoring tool for in vitro transaminase-catalyzed synthesis of a pharmaceutically relevant amine precursor

Authors: Madsen, Julie Østerby; Topalian, Sebastian Olivier Nymann; id_orcid 0000-0002-2339-2073; Jacobsen, Mikkel Fog; Skovby, Tommy; Gernaey, Krist V; id_orcid 0000-0002-0364-1773; Myerson, Allan S; Woodley, John; id_orcid 0000-0002-7976-2483

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f7fda0c3-ae47-4d1e-94d7-439cc701affe

Thesis Addressing raw material variability: in-line FTIR sugar composition analysis of lignocellulosic process streams

Waldschitz, Daniel; Bus, Yannick; Herwig, Christoph et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Addressing raw material variability: in-line FTIR sugar composition analysis of lignocellulosic process streams

Authors: Waldschitz, Daniel; Bus, Yannick; Herwig, Christoph; Kager, Julian; id_orcid 0000-0001-7274-6678; Spadiut, Oliver

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b83db1b5-7795-406c-a10f-df72fdb36444

Thesis Towards Industry 4.0 in the Bioprocessing Industries: ’Real-time’ monitoring and control of lignocellulosic ethanol fermentations

Lopez, Pau Cabañeros · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Towards Industry 4.0 in the Bioprocessing Industries: ’Real-time’ monitoring and control of lignocellulosic ethanol fermentations

Authors: Lopez, Pau Cabañeros

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c5213ed1-14f8-4b79-bd14-4cf06561d35e

Thesis Multi-function microfluidic platform for sensor integration

Fernandes, Ana C.; Semenova, Daria; Panjan, Peter et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Multi-function microfluidic platform for sensor integration

Authors: Fernandes, Ana C.; Semenova, Daria; Panjan, Peter; Sesay, Adama M.; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Krühne, Ulrich; id_orcid 0000-0001-7774-7442

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/eaed4eb0-30eb-4527-b02f-072563b02e0f

Thesis Application of Multivariate Analysis Tools to Industrial Scale Fermentation Data

Mears, Lisa; Nørregård, Rasmus; Stocks, Stuart M. et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Application of Multivariate Analysis Tools to Industrial Scale Fermentation Data

Authors: Mears, Lisa; Nørregård, Rasmus; Stocks, Stuart M.; Albæk, Mads O.; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Villez, Kris

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d6574e30-e890-4fdf-aa5a-4378505d80bc

Thesis Online estimation of changing metabolic capacities in continuous Corynebacterium glutamicum cultivations growing on a complex sugar mixture

Sinner, Peter; Stiegler, Marlene; Goldbeck, Oliver et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Online estimation of changing metabolic capacities in continuous Corynebacterium glutamicum cultivations growing on a complex sugar mixture

Authors: Sinner, Peter; Stiegler, Marlene; Goldbeck, Oliver; Seibold, Gerd M.; id_orcid 0000-0002-9823-8134; Herwig, Christoph; Kager, Julian; id_orcid 0000-0001-7274-6678

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e1d47952-5939-40df-b5d8-a033a58e8745

Thesis Model Predictive Control of dissolved oxygen level in an intermittent fed-batch process – Simulation & Application

Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Model Predictive Control of dissolved oxygen level in an intermittent fed-batch process – Simulation & Application

Authors: Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235; Kager, Julian; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/fe55fd04-e378-4860-b304-b314688d1774

Thesis On-line monitoring of fermentation processes using multi-wavelength fluorescence

Odman, Peter; Petersen, Nanna; Johansen, Claus Lindvald et al. · 2007 · Technical University of Denmark (DTU) · DOI

Full title: On-line monitoring of fermentation processes using multi-wavelength fluorescence

Authors: Odman, Peter; Petersen, Nanna; Johansen, Claus Lindvald; Olsson, Lisbeth; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Eliasson Lantz, Anna

Year: 2007

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/02bdfefe-3b85-46c1-b189-df722b23a750

Thesis Applying an MPC algorithm to the dissolved oxygen level of an intermittent fed-batch process

Pably, P.; Huusom, J. K.; id_orcid 0000-0002-1367-7235 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Applying an MPC algorithm to the dissolved oxygen level of an intermittent fed-batch process

Authors: Pably, P.; Huusom, J. K.; id_orcid 0000-0002-1367-7235; Kager, J.; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e5bf89bb-2803-4e21-a9e6-46f1fe8b45c3

Thesis On-line monitoring of fermentation of 2G bioethanol

Lopez, Pau Cabañeros; André Fernandes C., Ricardo; Junicke, Helena et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: On-line monitoring of fermentation of 2G bioethanol

Authors: Lopez, Pau Cabañeros; André Fernandes C., Ricardo; Junicke, Helena; id_orcid 0000-0002-2513-2486; Mauricio-Iglesias, Miguel; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e86079f8-9a99-4f3d-a428-8d8cc501585b

Thesis Novel strategies for control of fermentation processes

Mears, Lisa · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Novel strategies for control of fermentation processes

Authors: Mears, Lisa

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f0e5a504-744d-491b-be8f-d469c1d71bca

Thesis Quantitative monitoring of yeast fermentation using Raman spectroscopy

Iversen, Jens A.; Berg, Rolf W.; id_orcid 0000-0002-3195-1867 et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: Quantitative monitoring of yeast fermentation using Raman spectroscopy

Authors: Iversen, Jens A.; Berg, Rolf W.; id_orcid 0000-0002-3195-1867; Ahring, Birgitte K.

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/06284178-c14c-4a25-87bf-8b088466fba3

Thesis Hybrid machine learning assisted modelling framework for particle processes

Nielsen, Rasmus Fjordbak; id_orcid 0000-0002-3830-8743; Nazemzadeh, Nima et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Hybrid machine learning assisted modelling framework for particle processes

Authors: Nielsen, Rasmus Fjordbak; id_orcid 0000-0002-3830-8743; Nazemzadeh, Nima; id_orcid 0000-0002-9215-3519; Sillesen, Laura Wind; Andersson, Martin Peter; id_orcid 0000-0002-4921-1461; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Mansouri, Seyed Soheil; id_orcid 0000-0002-0924-4947

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/fe5d684e-7028-46f6-af37-4b22552d3206

Thesis Novel strategies for control of fermentation processes

Mears, Lisa; Stocks, Stuart; Sin, Gürkan et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Novel strategies for control of fermentation processes

Authors: Mears, Lisa; Stocks, Stuart; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Villez, Kris

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0a72255f-95c0-49d4-a1a0-94bd2bf871b1

Thesis Hybrid Modelling for Enhanced Bioreactor Performance

Thaysen, Mads · 2006 · Technical University of Denmark (DTU) · DOI

Full title: Hybrid Modelling for Enhanced Bioreactor Performance

Authors: Thaysen, Mads

Year: 2006

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0bf63473-e65c-4330-b41d-de9efc18fe1c

Thesis A probabilistic model-based soft sensor to monitor lactic acid bacteria fermentations

Spann, Robert; id_orcid 0000-0003-1223-2805; Roca, Christophe et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: A probabilistic model-based soft sensor to monitor lactic acid bacteria fermentations

Authors: Spann, Robert; id_orcid 0000-0003-1223-2805; Roca, Christophe; Kold, David; Eliasson Lantz, Anna; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Sin, Gürkan; id_orcid 0000-0003-0513-4502

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/06a320b8-2a66-40cf-9b98-d296481ec8b7

Thesis Chemometrics and visible-near infrared spectroscopic monitoring of red wine fermentation in a pilot scale

Cozzolino, Daniel; Parker, Mango; Dambergs, Robert et al. · 2006 · Charles Sturt University - Research Output · DOI

Full title: Chemometrics and visible-near infrared spectroscopic monitoring of red wine fermentation in a pilot scale

Authors: Cozzolino, Daniel; Parker, Mango; Dambergs, Robert; id_orcid 0000-0001-8366-4264; Herderich, Markus; Gishen, Mark

Year: 2006

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/14953c3a-fc24-4de5-9546-bad52304aea3

Thesis Good Modeling Practice for PAT Applications: Propagation of Input Uncertainty and Sensitivity Analysis

Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist et al. · 2009 · Technical University of Denmark (DTU) · DOI

Full title: Good Modeling Practice for PAT Applications: Propagation of Input Uncertainty and Sensitivity Analysis

Authors: Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Eliasson Lantz, Anna

Year: 2009

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/191480e1-8129-4da7-9f2f-df3c21086144

Thesis On-line cell mass monitoring of Saccharomyces cerevisiae cultivations by multi-wavelength fluorescence

Haack, Martin Brian; Eliasson, Anna; Olsson, Lisbeth · 2004 · Technical University of Denmark (DTU) · DOI

Full title: On-line cell mass monitoring of Saccharomyces cerevisiae cultivations by multi-wavelength fluorescence

Authors: Haack, Martin Brian; Eliasson, Anna; Olsson, Lisbeth

Year: 2004

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/221e301a-f593-4fc5-9fbd-461e7cd8f543

Thesis Multichannel Bipotentiostat Integrated With a Microfluidic Platform for Electrochemical Real-Time Monitoring of Cell Cultures

Vergani, Marco; Carminati, Marco; Ferrari, Giorgio et al. · 2012 · Technical University of Denmark (DTU) · DOI

Full title: Multichannel Bipotentiostat Integrated With a Microfluidic Platform for Electrochemical Real-Time Monitoring of Cell Cultures

Authors: Vergani, Marco; Carminati, Marco; Ferrari, Giorgio; Landini, Ettore; Caviglia, Claudia; Heiskanen, Arto; id_orcid 0000-0002-7124-8420; Comminges, Clément; Zor, Kinga; id_orcid 0000-0002-2905-4155; Sabourin, David; Dufva, Martin; id_orcid 0000-0001-5449-0189; Dimaki, Maria; id_orcid 0000-0001-5037-2388; Raiteri, Roberto; Wollenberger, Ulla; Emnéus, Jenny; id_orcid 0000-0002-8061-201X; Sampietro, Marco

Year: 2012

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/15611ea3-644b-4cfc-9adf-08153fd5ff5a

Thesis Simultaneous real-time estimation of maximum substrate uptake capacity and yield coefficient in induced microbial cultures

Müller, Don Fabian; Wibbing, Daniel; Herwig, Christoph et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Simultaneous real-time estimation of maximum substrate uptake capacity and yield coefficient in induced microbial cultures

Authors: Müller, Don Fabian; Wibbing, Daniel; Herwig, Christoph; Kager, Julian; id_orcid 0000-0001-7274-6678

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0c248b7d-bf0c-43c4-a5b3-532cb4003c87

Thesis Wine and beer

Cozzolino, Daniel; Dambergs, Robert; id_orcid 0000-0001-8366-4264 · 2009 · Charles Sturt University - Research Output · DOI

Full title: Wine and beer

Authors: Cozzolino, Daniel; Dambergs, Robert; id_orcid 0000-0001-8366-4264

Year: 2009

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/2ad4208b-d7dd-4c71-a344-77c83de6c8f0

Thesis Mechanistic modeling of product formation in recombinant Escherichia coli cultivations

Müller, Don Fabian; Pably, Philipp; Wibbing, Daniel et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Mechanistic modeling of product formation in recombinant Escherichia coli cultivations

Authors: Müller, Don Fabian; Pably, Philipp; Wibbing, Daniel; Kager, Julian; id_orcid 0000-0001-7274-6678; Herwig, Christoph

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/13a15152-c0d5-40da-911e-89a5b0f3874b

Thesis Raw material quality assessment approaches comparison in pectin production

André Fernandes Caroço, Ricardo; Bevilacqua, Marta; Armagan, Ibrahim et al. · 2019 · University of Copenhagen · DOI

Full title: Raw material quality assessment approaches comparison in pectin production

Authors: André Fernandes Caroço, Ricardo; Bevilacqua, Marta; Armagan, Ibrahim; Santacoloma, Paloma A.; Abildskov, Jens; Skov, Thomas; Huusom, Jakob Kjøbsted

Year: 2019

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/186d4f11-fdf2-4d64-afe2-98529a196b02

Thesis Comparison of noninvasive, in-situ and external monitoring of microbial growth in fed-batch cultivations in Corynebacterium glutamicum

Lira-Parada, Pedro A.; Tuveri, Andrea; Seibold, Gerd M. et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Comparison of noninvasive, in-situ and external monitoring of microbial growth in fed-batch cultivations in Corynebacterium glutamicum

Authors: Lira-Parada, Pedro A.; Tuveri, Andrea; Seibold, Gerd M.; id_orcid 0000-0002-9823-8134; Bar, Nadav

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2af65589-a5cf-48ba-a9cb-f024e8ea03d1

Thesis Additive manufacturing of prototype elements with process interfaces for continuously operating manufacturing lines:Formulation strategies and manufacturing technologies to enhance non-invasive drug delivery

Hirschberg, Cosima; Schmidt Larsen, Mikkel; Bøtker, Johan Peter et al. · 2018 · University of Copenhagen · DOI

Full title: Additive manufacturing of prototype elements with process interfaces for continuously operating manufacturing lines:Formulation strategies and manufacturing technologies to enhance non-invasive drug delivery

Authors: Hirschberg, Cosima; Schmidt Larsen, Mikkel; Bøtker, Johan Peter; Rantanen, Jukka

Year: 2018

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/26c145a8-c775-4eb9-ad16-b1e5b480d34b

Thesis Mechanistic modeling of industrial fermentation processes for antibiotic production

Magnusson, Atli Freyr; id_orcid 0000-0003-4060-2965; Stocks, Stuart M. et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Mechanistic modeling of industrial fermentation processes for antibiotic production

Authors: Magnusson, Atli Freyr; id_orcid 0000-0003-4060-2965; Stocks, Stuart M.; P. Pajander, Jari; Sin, Gürkan; id_orcid 0000-0003-0513-4502

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2e7d69cb-d49f-430a-b85d-e71243e63860

Thesis Towards Digitalization in Bio-Manufacturing Operations: A Survey on Application of Big Data and Digital Twin Concepts in Denmark

A. Udugama, Isuru; Öner, Merve; Lopez, Pau C. et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Towards Digitalization in Bio-Manufacturing Operations: A Survey on Application of Big Data and Digital Twin Concepts in Denmark

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3b235ea5-e6fe-4ae1-ab77-68ef017d8a55

Thesis Monitoring yeast fermentations by nonlinear infrared technology and chemometrics-understanding process correlations and indirect predictions

Pontius, Katrin; Junicke, Helena; id_orcid 0000-0002-2513-2486 et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Monitoring yeast fermentations by nonlinear infrared technology and chemometrics-understanding process correlations and indirect predictions

Authors: Pontius, Katrin; Junicke, Helena; id_orcid 0000-0002-2513-2486; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Bevilacqua, Marta

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2fba9be3-176c-43ae-96fd-694952fade50

Thesis Towards a digital twin: a hybrid data‐driven and mechanistic digital shadow to forecast the evolution of lignocellulosic fermentation

Lopez, Pau Cabañeros; Udugama, Isuru A.; Thomsen, Sune Tjalfe et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Towards a digital twin: a hybrid data‐driven and mechanistic digital shadow to forecast the evolution of lignocellulosic fermentation

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2c30c0c9-78cc-47a9-a575-7eff034581f2

Thesis Mechanistic Modelling for Risk-Based Monitoring of Lactic Acid Bacteria Cultivations

Spann, Robert; id_orcid 0000-0003-1223-2805 · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Mechanistic Modelling for Risk-Based Monitoring of Lactic Acid Bacteria Cultivations

Authors: Spann, Robert; id_orcid 0000-0003-1223-2805

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2c6994fa-1b56-43d2-b037-9a4a2ff8321c

Thesis Determining the linear correlation between dielectric spectroscopy and viable biomass concentration in filamentous fungal fermentations

Magnússon, Atli; id_orcid 0000-0003-4060-2965; Pajander, Jari et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Determining the linear correlation between dielectric spectroscopy and viable biomass concentration in filamentous fungal fermentations

Authors: Magnússon, Atli; id_orcid 0000-0003-4060-2965; Pajander, Jari; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Stocks, Stuart

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/341dab79-38a5-4b5b-8d46-857102473ea9

Thesis On-line monitoring of process parameters during fermentation

Gargalo, Carina L.; id_orcid 0000-0002-8740-9591; Lopez, Pau Cabaneros et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: On-line monitoring of process parameters during fermentation

Authors: Gargalo, Carina L.; id_orcid 0000-0002-8740-9591; Lopez, Pau Cabaneros; Hasanzadeh, Aliyeh; id_orcid 0000-0001-7505-7317; Udugama, Isuru A.; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2d05766b-b595-457f-8e2b-060b318cea22

Thesis Implementation of real-time incremental learning for ensemble hybrid model prediction in pilot scale bubble column aeration

Jul-Rasmussen, Peter; Stevnsborg, Mads; Liang, Xiaodong et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Implementation of real-time incremental learning for ensemble hybrid model prediction in pilot scale bubble column aeration

Authors: Jul-Rasmussen, Peter; Stevnsborg, Mads; Liang, Xiaodong; id_orcid 0000-0002-2007-546X; Huusom, Jakob Kjøbsted; id_orcid 0000-0002-1367-7235

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3a281c09-30fc-4659-9dc6-33d64f78b7b8

Thesis Moisture and drug solid-state monitoring during a continuous drying process using empirical and mass balance models

Fonteyne, Margot; Gildemyn, Delphine; Peeters, Elisabeth et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: Moisture and drug solid-state monitoring during a continuous drying process using empirical and mass balance models

Authors: Fonteyne, Margot; Gildemyn, Delphine; Peeters, Elisabeth; Mortier, Séverine Thérèse F.C.; Vercruysse, Jurgen; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Vervaet, Chris; Remon, Jean Paul; Nopens, Ingmar; De Beer, Thomas

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/43807e78-b60a-4b93-8089-5150d1174a46

Thesis Fast measurement of phosphates and ammonium in fermentation-like media:A feasibility study

Pontius, Katrin; Praticò, Giulia; Larsen, Flemming H. et al. · 2020 · University of Copenhagen · DOI

Full title: Fast measurement of phosphates and ammonium in fermentation-like media:A feasibility study

Authors: Pontius, Katrin; Praticò, Giulia; Larsen, Flemming H.; Skov, Thomas; Arneborg, Nils; Lantz, Anna Eliasson; Bevilacqua, Marta

Year: 2020

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/38a62381-f9e1-43b6-afb3-71d116129a48

Thesis Hybrid machine-learning for dynamic plant-wide biomanufacturing

Shahhoseyni, Shabnam; Chakraborty, Arijit; Boskabadi, Mohammad Reza et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Hybrid machine-learning for dynamic plant-wide biomanufacturing

Authors: Shahhoseyni, Shabnam; Chakraborty, Arijit; Boskabadi, Mohammad Reza; Venkatasubramanian, Venkat; Mansouri, Seyed Soheil; id_orcid 0000-0002-0924-4947

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/31b83b7d-b842-484f-9d03-65c948d398c6

Thesis Model-based Computer Aided Framework for Design of Process Monitoring and Analysis Systems

Singh, Ravendra; Gernaey, Krist; id_orcid 0000-0002-0364-1773 et al. · 2009 · Technical University of Denmark (DTU) · DOI

Full title: Model-based Computer Aided Framework for Design of Process Monitoring and Analysis Systems

Authors: Singh, Ravendra; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Gani, Rafiqul

Year: 2009

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3a6e7cfa-5506-40bc-8c6e-b58cf76a5598

Thesis Near infrared and acoustic chemometrics monitoring of volatile fatty acids and dry matter during co-digestion of manure and maize silage

Lomborg, Carina J.; Holm-Nielsen, Jens Bo; Oleskowicz-Popiel, Piotr et al. · 2009 · Technical University of Denmark (DTU) · DOI

Full title: Near infrared and acoustic chemometrics monitoring of volatile fatty acids and dry matter during co-digestion of manure and maize silage

Authors: Lomborg, Carina J.; Holm-Nielsen, Jens Bo; Oleskowicz-Popiel, Piotr; Esbensen, Kim H.

Year: 2009

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3915c874-5180-4804-aa10-5c89420fb067

Thesis Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Martínez-Monge, I.; Martínez, C.; Decker, M. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Authors: Martínez-Monge, I.; Martínez, C.; Decker, M.; Udugama, I. A.; Marín de Mas, I.; Gernaey, K. V.; id_orcid 0000-0002-0364-1773; Nielsen, L. K.

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3b1685d4-5ab9-4737-b414-d28fecf9b9eb

Thesis Accelerating Vaccine Manufacturing Development through Model-Based Approaches: Current Advances and Future Opportunities

Ramin, Elham; id_orcid 0000-0002-2301-7492; Cardillo, Antonio Gaetano et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Accelerating Vaccine Manufacturing Development through Model-Based Approaches: Current Advances and Future Opportunities

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/438c59d4-d768-4ed9-8894-06993d050d91

Thesis A “real‐time” sequential hybrid modeling approach to monitor and forecast key process variables in ethanol fermentation using lignocellulosic feedstocks

Lopez, Pau Cabañeros; Udugama, Isuru; Thomsen, Sune Tjalfe et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: A “real‐time” sequential hybrid modeling approach to monitor and forecast key process variables in ethanol fermentation using lignocellulosic feedstocks

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3a162256-b10e-48e0-89bf-1d67d41c02b3

Thesis Data-driven soft sensor design with multiple-rate sampled data: a comparative study

Lin, Bao; Recke, Bodil; Schmidt, Torben M. et al. · 2009 · Technical University of Denmark (DTU) · DOI

Full title: Data-driven soft sensor design with multiple-rate sampled data: a comparative study

Authors: Lin, Bao; Recke, Bodil; Schmidt, Torben M.; Knudsen, Jørgen K.H.; Jørgensen, Sten Bay; id_orcid 0000-0002-3179-972X

Year: 2009

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/460537b5-c708-462c-9997-ba04d49aec58

Thesis An all-in-one state-observer for protein refolding reactions using particle filters and delayed measurements

Pauk, Jan Niklas; Igwe, Chika Linda; Herwig, Christoph et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: An all-in-one state-observer for protein refolding reactions using particle filters and delayed measurements

Authors: Pauk, Jan Niklas; Igwe, Chika Linda; Herwig, Christoph; Kager, Julian; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/43b69497-a5a8-42c2-a0b3-6c75473918f9

Thesis Systematic Methodology for Reproducible Optimizing Batch Operation

Bonné, Dennis; Jørgensen, Sten Bay; id_orcid 0000-0002-3179-972X · 2006 · Technical University of Denmark (DTU) · DOI

Full title: Systematic Methodology for Reproducible Optimizing Batch Operation

Authors: Bonné, Dennis; Jørgensen, Sten Bay; id_orcid 0000-0002-3179-972X

Year: 2006

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4b220b1c-6bd2-4eb7-ac7f-0f5353ddfeb6

Thesis Data Driven Modeling for Monitoring and Control of Industrial Fed-Batch Cultivations

Bonné, Dennis; Alvarez, María Antonieta; Jørgensen, Sten Bay et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: Data Driven Modeling for Monitoring and Control of Industrial Fed-Batch Cultivations

Authors: Bonné, Dennis; Alvarez, María Antonieta; Jørgensen, Sten Bay; id_orcid 0000-0002-3179-972X

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5b645498-f94f-4c2d-bcc1-fd47ad529ccd

Thesis Optics miniaturization strategy for demanding Raman spectroscopy applications

Ilchenko, Oleksii; id_orcid 0000-0002-2150-895X; Pilhun, Yurii et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Optics miniaturization strategy for demanding Raman spectroscopy applications

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/65c2a878-1298-4d94-b404-fb32ae75d80d

Thesis Model Predictive Control of dissolved oxygen level in an intermittent fed-batch process – Simulation & Application

Pably, P.; Huusom, J. K.; id_orcid 0000-0002-1367-7235 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Model Predictive Control of dissolved oxygen level in an intermittent fed-batch process – Simulation & Application

Authors: Pably, P.; Huusom, J. K.; id_orcid 0000-0002-1367-7235; Kager, J.; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/67f0a177-939b-4449-92b5-edae7e087c69

Thesis In Situ Near Infrared Spectroscopy for Analyte-Specific Monitoring of Glucose and Ammonium in Streptomyces coelicolor Fermentations

Petersen, Nanna; Ödman, Peter; Cervera Padrell, Albert Emili et al. · 2010 · Technical University of Denmark (DTU) · DOI

Full title: In Situ Near Infrared Spectroscopy for Analyte-Specific Monitoring of Glucose and Ammonium in Streptomyces coelicolor Fermentations

Authors: Petersen, Nanna; Ödman, Peter; Cervera Padrell, Albert Emili; Stocks, S.; Eliasson Lantz, Anna; Gernaey, Krist; id_orcid 0000-0002-0364-1773

Year: 2010

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5fcb6f42-5a10-455f-8d49-b0bd991e1b5b

Thesis Potential of predictive model-based dissolved oxygen control for intermittent fed-batch processes

Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Potential of predictive model-based dissolved oxygen control for intermittent fed-batch processes

Authors: Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235; Kager, Julian; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/672b1410-685c-430d-9a82-cd4a33c61d66

Thesis Design and development of electrochemical polymer-based lab-on-a-disc devices for biological applications

Sanger, Kuldeep · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Design and development of electrochemical polymer-based lab-on-a-disc devices for biological applications

Authors: Sanger, Kuldeep

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/6d310172-65be-4d90-a18d-66fbedc1d77c

Thesis Automated Electrochemical Glucose Biosensor Platform as an Efficient Tool Toward On-Line Fermentation Monitoring:Novel Application Approaches and Insights

Pontius, Katrin; Semenova, Daria; Silina, Yuliya E. et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Automated Electrochemical Glucose Biosensor Platform as an Efficient Tool Toward On-Line Fermentation Monitoring:Novel Application Approaches and Insights

Authors: Pontius, Katrin; Semenova, Daria; Silina, Yuliya E.; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Junicke, Helena; id_orcid 0000-0002-2513-2486

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/715e756f-cf70-460c-b319-b3014dd5729d

Thesis Advanced modeling of industrial-scale fermentation process for antibiotic production

Magnusson, Atli Freyr; id_orcid 0000-0003-4060-2965 · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Advanced modeling of industrial-scale fermentation process for antibiotic production

Authors: Magnusson, Atli Freyr; id_orcid 0000-0003-4060-2965

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5ec6b30f-579e-465d-b28a-5223114e5c8d

Thesis Automated compartment model development based on data from flow-following sensor devices

Bisgaard, Jonas; Tajsoleiman, Tannaz; id_orcid 0000-0001-8543-4585 et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Automated compartment model development based on data from flow-following sensor devices

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7871337b-69b9-4a30-a085-eff52694deb6

Thesis Transforming data to information: A parallel hybrid model for real-time state estimation in lignocellulosic ethanol fermentations

Lopez, Pau Cabañeros; Udugama, Isuru A.; Thomsen, Sune Tjalfe et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Transforming data to information: A parallel hybrid model for real-time state estimation in lignocellulosic ethanol fermentations

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/73a15f9b-df7c-4935-9424-e542ba4f7ab9

Thesis Sensor combination and chemometric variable selection for online monitoring of Streptomyces coelicolor fed-batch cultivations

Ödman, Peter; Johansen, C.L.; Olsson, L. et al. · 2010 · Technical University of Denmark (DTU) · DOI

Full title: Sensor combination and chemometric variable selection for online monitoring of Streptomyces coelicolor fed-batch cultivations

Authors: Ödman, Peter; Johansen, C.L.; Olsson, L.; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Eliasson Lantz, Anna

Year: 2010

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7910d790-1e56-4476-89b2-7e05b53b456a

Thesis Raw material quality assessment approaches comparison in pectin production

Caroço, Ricardo F.; Bevilacqua, Marta; Armagan, Ibrahim et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Raw material quality assessment approaches comparison in pectin production

Authors: Caroço, Ricardo F.; Bevilacqua, Marta; Armagan, Ibrahim; Santacoloma, Paloma A.; Abildskov, Jens; id_orcid 0000-0003-1187-8778; Skov, Thomas; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/72ad7018-cbc0-4ce1-861b-9224a96ed072

Thesis In-silico process design and evaluation tool for pharmaceutical manufacturing

do Carmo Montes, Frederico da Conceicao · 2020 · Technical University of Denmark (DTU) · DOI

Full title: In-silico process design and evaluation tool for pharmaceutical manufacturing

Authors: do Carmo Montes, Frederico da Conceicao

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7cd25837-dafc-4484-b16b-af385ad1fce6

Thesis New developments in online OUR monitoring and its application to animal cell cultures

Martínez-Monge, I; Roman, R.; Comas, P. et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: New developments in online OUR monitoring and its application to animal cell cultures

Authors: Martínez-Monge, I; Roman, R.; Comas, P.; Fontova, A.; Lecina, M.; Casablancas, A.; Cairó, J J

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/8986a5a2-6603-4730-bb85-0c9865f51e7b

Thesis Robust Monitoring of Lactic Acid Bacteria with Sequential Monte Carlo

Pahija, Ergys; Spann, Robert; Sin, Gürkan et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Robust Monitoring of Lactic Acid Bacteria with Sequential Monte Carlo

Authors: Pahija, Ergys; Spann, Robert; Sin, Gürkan; id_orcid 0000-0003-0513-4502

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/82e883bb-6a5f-4ff8-ba8e-1a98e05f9069

Thesis Harvest time prediction for batch processes

Spooner, Max Peter; Kold, David; Kulahci, Murat et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Harvest time prediction for batch processes

Authors: Spooner, Max Peter; Kold, David; Kulahci, Murat; id_orcid 0000-0003-4222-9631

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a5a9f2c7-da9c-4a06-8c72-3a364d5bb0e5

Thesis Fast measurement of phosphates and ammonium in fermentation-like media: a feasibility study

Pontius, Katrin; Praticò, Giulia; Larsen, Flemming H et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Fast measurement of phosphates and ammonium in fermentation-like media: a feasibility study

Authors: Pontius, Katrin; Praticò, Giulia; Larsen, Flemming H; Skov, Thomas; Arneborg, Nils; Eliasson Lantz, Anna; Bevilacqua, Marta

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/8a513d88-d298-4a40-82d6-707c3c58053c

Thesis Liquid‐to‐solid ratio control as an advanced process control solution for continuous twin‐screw wet granulation

Nicolaï, Niels; Leersnyder, Fien De; Copot, Dana et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Liquid‐to‐solid ratio control as an advanced process control solution for continuous twin‐screw wet granulation

Authors: Nicolaï, Niels; Leersnyder, Fien De; Copot, Dana; Stock, Michiel; Ionescu, Clara M.; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Nopens, Ingmar; Beer, Thomas De

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/80826ff1-81c5-4d2f-b430-bc84c3a886b6

Thesis Bringing a scalable adaptive hybrid modeling framework closer to industrial use: Application on a multiscale fungal fermentation

Rydal, Thomas; Frandsen, Jesper; Nadal-Rey, Gisela et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Bringing a scalable adaptive hybrid modeling framework closer to industrial use: Application on a multiscale fungal fermentation

Authors: Rydal, Thomas; Frandsen, Jesper; Nadal-Rey, Gisela; Albæk, Mads Orla; Ramin, Pedram; id_orcid 0000-0001-7245-072X

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/818c461a-a4db-4668-9732-9f02791c25c7

Thesis On-line monitoring of fermentation processes for 2G bioethanol production

Lopez, Pau Cabañeros; André Fernandes , Ricardo C.; Junicke, Helena et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: On-line monitoring of fermentation processes for 2G bioethanol production

Authors: Lopez, Pau Cabañeros; André Fernandes , Ricardo C.; Junicke, Helena; id_orcid 0000-0002-2513-2486; Mauricio-Iglesias, Miguel; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/903229bf-0b12-48a9-968b-d89c6bcbdd47

Thesis Development and Application of a Novel Free-floating Sensor Device for Bioprocess Optimization

Bisgaard, Jonas · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Development and Application of a Novel Free-floating Sensor Device for Bioprocess Optimization

Authors: Bisgaard, Jonas

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a5765731-0e3a-4e97-942e-0b93dbe22c31

Thesis IR-spectroscopy and PLS modelling for advanced bio-process monitoring: simultaneous and rapid sensing of various components

Pontius, Katrin; Bevilacqua, Marta; Junicke, Helena et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: IR-spectroscopy and PLS modelling for advanced bio-process monitoring: simultaneous and rapid sensing of various components

Authors: Pontius, Katrin; Bevilacqua, Marta; Junicke, Helena; id_orcid 0000-0002-2513-2486; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/93c1f2e3-1971-4783-b94f-5b5c18c6036d

Thesis Continuous ethanol production via ultrasound-enhanced yeast sedimentation

Domingo-Félez, Carlos; Jankowska, Katarzyna; id_orcid 0000-0002-3283-0338 et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Continuous ethanol production via ultrasound-enhanced yeast sedimentation

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9dd0dd08-655a-429c-a5bc-6186023c6c6b

Thesis Design and Application of an Electrochemical Sensor for Ammonium Monitoring in Bioprocesses

Hasanzadeh, Aliyeh; id_orcid 0000-0001-7505-7317; Junicke, Helena et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Design and Application of an Electrochemical Sensor for Ammonium Monitoring in Bioprocesses

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a15773cf-19f1-4a40-8168-2c0e66261a3c

Thesis Fourier Transform Infrared Spectroscopy Tracking of Fermentation of Oat and Pea Bases for Yoghurt-Type Products

Greulich, Olivia; Duedahl-Olesen, Lene; id_orcid 0000-0002-3162-0101 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Fourier Transform Infrared Spectroscopy Tracking of Fermentation of Oat and Pea Bases for Yoghurt-Type Products

Authors: Greulich, Olivia; Duedahl-Olesen, Lene; id_orcid 0000-0002-3162-0101; Mikkelsen, Mette Skau; Smedsgaard, Jørn; Bang-Berthelsen, Claus Heiner; id_orcid 0000-0003-4541-2538

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b021d179-47d4-4a12-bb2e-fbc232ed7ca5

Thesis Multivariate analysis of industrial scale fermentation data

Mears, Lisa; Nørregård, Rasmus; Stocks, Stuart et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Multivariate analysis of industrial scale fermentation data

Authors: Mears, Lisa; Nørregård, Rasmus; Stocks, Stuart; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Villez, Kris

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a481700c-5fd9-4857-b39c-877760461b94

Thesis Semi-on-line analysis for fast and precise monitoring of bioreaction processes.

Christensen, L.H.; Marcher, J.; Schulze, Ulrik et al. · 1996 · Technical University of Denmark (DTU) · DOI

Full title: Semi-on-line analysis for fast and precise monitoring of bioreaction processes.

Authors: Christensen, L.H.; Marcher, J.; Schulze, Ulrik; Carlsen, Morten; Min, R.W.; Nielsen, Jens Bredal; Villadsen, John; id_orcid 0000-0002-6523-8445

Year: 1996

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/8d8d3480-5f2f-40e1-9716-5c278e95e6e8

Thesis A Semi-supervised Soft-sensor of Just-in-time Learning With Structure Entropy Clustering and Applications for Industrial Processes Monitoring

Li, Dong; Liu, Yiqi; id_orcid 0000-0001-8911-727X et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: A Semi-supervised Soft-sensor of Just-in-time Learning With Structure Entropy Clustering and Applications for Industrial Processes Monitoring

Authors: Li, Dong; Liu, Yiqi; id_orcid 0000-0001-8911-727X; Huang, Daoping; Xu, Chong

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a070087c-170b-4c8d-8ac3-35eb49159eb8

Thesis Data fusion of Raman spectra in MSPC for fault detection and diagnosis in pharmaceutical manufacturing

Jul-Jørgensen, I.; id_orcid 0000-0003-1335-3772; Facco, P. et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Data fusion of Raman spectra in MSPC for fault detection and diagnosis in pharmaceutical manufacturing

Authors: Jul-Jørgensen, I.; id_orcid 0000-0003-1335-3772; Facco, P.; Gernaey, K.V.; id_orcid 0000-0002-0364-1773; Barolo, M.; Hundahl, C.A.

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/aad08ef8-555b-4334-8183-d75d48893d65

Thesis Model-based Monitoring and Optimization of a Bio-based Process

Fernandes Caroço, Ricardo · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Model-based Monitoring and Optimization of a Bio-based Process

Authors: Fernandes Caroço, Ricardo

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9e5fd38b-9431-4535-bbc4-fdb7b96812c5

Thesis Application of near-infrared spectroscopy for monitoring and control of cell culture and fermentation

Cervera Padrell, Albert Emili; Petersen, Nanna; Eliasson Lantz, Anna et al. · 2009 · Technical University of Denmark (DTU) · DOI

Full title: Application of near-infrared spectroscopy for monitoring and control of cell culture and fermentation

Authors: Cervera Padrell, Albert Emili; Petersen, Nanna; Eliasson Lantz, Anna; Larsen, A.; Gernaey, Krist; id_orcid 0000-0002-0364-1773

Year: 2009

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a124ef29-e0e8-4bb7-a5e6-217a3def4c06

Thesis Analysis of beverages and brewing products

Dambergs, Robert; id_orcid 0000-0001-8366-4264; Esler, Michael et al. · 2015 · Charles Sturt University - Research Output · DOI

Full title: Analysis of beverages and brewing products

Authors: Dambergs, Robert; id_orcid 0000-0001-8366-4264; Esler, Michael; Gishen, Mark

Year: 2015

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/b5accfc1-9e53-4879-ad54-2f389620289a

Thesis Monitoring of Bioprocesses. Opportunities and challenges: Opportunities and Challenges

Pontius, Katrin · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Monitoring of Bioprocesses. Opportunities and challenges: Opportunities and Challenges

Authors: Pontius, Katrin

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/aa572dad-0089-4493-8034-c45b878839b8

Thesis Comparison of spectroscopy technologies for improved monitoring of cell culture processes in miniature bioreactors

Rowland-Jones, Ruth C.; van der Berg, Franciscus Winfried J; Racher, Andrew J. et al. · 2017 · University of Copenhagen · DOI

Full title: Comparison of spectroscopy technologies for improved monitoring of cell culture processes in miniature bioreactors

Authors: Rowland-Jones, Ruth C.; van der Berg, Franciscus Winfried J; Racher, Andrew J.; Martin, Elaine B.; Jaques, Colin

Year: 2017

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/b0ba0d28-f1e5-4abb-be69-231b4094c928

Thesis Modernizing non-classical protein crystallization through industry 4.0: Advanced monitoring and modelling utilizing process analytical technology

Jul-Jørgensen, I.; id_orcid 0000-0003-1335-3772; Oliver, R. et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Modernizing non-classical protein crystallization through industry 4.0: Advanced monitoring and modelling utilizing process analytical technology

Authors: Jul-Jørgensen, I.; id_orcid 0000-0003-1335-3772; Oliver, R.; Gernaey, K. V.; id_orcid 0000-0002-0364-1773; Hundahl, C. A.

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b1a4c697-bd81-42c2-8b15-51ecb96da942

Thesis Addressing raw material variability: in-line FTIR sugar composition analysis of lignocellulosic process streams

Waldschitz, Daniel; Bus, Yannick; Herwig, Christoph et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Addressing raw material variability: in-line FTIR sugar composition analysis of lignocellulosic process streams

Authors: Waldschitz, Daniel; Bus, Yannick; Herwig, Christoph; Kager, Julian; id_orcid 0000-0001-7274-6678; Spadiut, Oliver

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b83db1b5-7795-406c-a10f-df72fdb36444

Thesis A compartment model for risk-based monitoring of lactic acid bacteria cultivations

Spann, Robert; id_orcid 0000-0003-1223-2805; Gernaey, Krist V. et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: A compartment model for risk-based monitoring of lactic acid bacteria cultivations

Authors: Spann, Robert; id_orcid 0000-0003-1223-2805; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Sin, Gürkan; id_orcid 0000-0003-0513-4502

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b48fccb9-5c2b-4d67-9980-a437405c4249

Thesis Real-time direct cell concentration and viability determination using a fully automated microfluidic platform for standalone process monitoring

Rodrigues de Sousa Nunes, Pedro André; Kjaerulff, S.; Dufva, Martin et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Real-time direct cell concentration and viability determination using a fully automated microfluidic platform for standalone process monitoring

Authors: Rodrigues de Sousa Nunes, Pedro André; Kjaerulff, S.; Dufva, Martin; id_orcid 0000-0001-5449-0189; Mogensen, Klaus Bo

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ba0ac0f2-477d-451c-8818-64d43996edb8

Thesis Development of an on-line state estimator for fed-batch filamentous fungal fermentations

Mears, Lisa; Stocks, Stuart M.; Albæk, Mads O. et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Development of an on-line state estimator for fed-batch filamentous fungal fermentations

Authors: Mears, Lisa; Stocks, Stuart M.; Albæk, Mads O.; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist; id_orcid 0000-0002-0364-1773

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b422bebe-f96c-4e37-a349-618f0c11d541

Mears, Lisa; Stocks, Stuart M.; Albæk, Mads Orla et al. · 2017 · Technical University of Denmark (DTU) · DOI

Authors: Mears, Lisa; Stocks, Stuart M.; Albæk, Mads Orla; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c64235e7-3d2e-4645-8c15-c5818953a8be

Thesis Extension of first principle elemental balancing soft-sensors by nonlinear reaction kinetics for increased robustness in bioprocess monitoring

Müller, Don Fabian; Wibbing, Daniel; Kager, Julian et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Extension of first principle elemental balancing soft-sensors by nonlinear reaction kinetics for increased robustness in bioprocess monitoring

Authors: Müller, Don Fabian; Wibbing, Daniel; Kager, Julian; id_orcid 0000-0001-7274-6678

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c79c6831-fab8-4ea5-af90-5e10a3fac54d

Thesis Real-Time DNP NMR Observations of Acetic Acid Uptake, Intracellular Acidification, and of Consequences for Glycolysis and Alcoholic Fermentation in Yeast

Jensen, Pernille Rose; id_orcid 0000-0003-4359-848X; Karlsson, Magnus et al. · 2013 · Technical University of Denmark (DTU) · DOI

Full title: Real-Time DNP NMR Observations of Acetic Acid Uptake, Intracellular Acidification, and of Consequences for Glycolysis and Alcoholic Fermentation in Yeast

Authors: Jensen, Pernille Rose; id_orcid 0000-0003-4359-848X; Karlsson, Magnus; id_orcid 0000-0001-7738-1700; Lerche, Mathilde Hauge; id_orcid 0000-0002-5899-2781; Meier, Sebastian; id_orcid 0000-0003-3761-3217

Year: 2013

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c2780c8e-8c75-43cb-8337-39f69d739ca3

Thesis Towards Industry 4.0 in the Bioprocessing Industries: ’Real-time’ monitoring and control of lignocellulosic ethanol fermentations

Lopez, Pau Cabañeros · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Towards Industry 4.0 in the Bioprocessing Industries: ’Real-time’ monitoring and control of lignocellulosic ethanol fermentations

Authors: Lopez, Pau Cabañeros

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c5213ed1-14f8-4b79-bd14-4cf06561d35e

Thesis Multimodal modelling of uneven batch data

Magnusson, Atli Freyr; id_orcid 0000-0003-4060-2965; Pajander, Jari et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Multimodal modelling of uneven batch data

Authors: Magnusson, Atli Freyr; id_orcid 0000-0003-4060-2965; Pajander, Jari; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Stocks, Stuart M.

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c7c6f14b-ba6b-4bf9-94e4-e38adda241f9

Thesis On-line monitoring of fermentation of 2G bioethanol

Lopez, Pau Cabañeros; André Fernandes C., Ricardo; Junicke, Helena et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: On-line monitoring of fermentation of 2G bioethanol

Authors: Lopez, Pau Cabañeros; André Fernandes C., Ricardo; Junicke, Helena; id_orcid 0000-0002-2513-2486; Mauricio-Iglesias, Miguel; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e86079f8-9a99-4f3d-a428-8d8cc501585b

Thesis Methods and tools for the statistical data analysis of large datasets collected from bio-based manufacturing processes

Spooner, Max Peter · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Methods and tools for the statistical data analysis of large datasets collected from bio-based manufacturing processes

Authors: Spooner, Max Peter

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c044b23c-a1c1-4a9c-a2cd-bac25ea815a4

Thesis A Systematic Approach for Soft Sensor Development

Lin, Bao; Recke, Bodil; Renaudat, Philippe et al. · 2007 · Technical University of Denmark (DTU) · DOI

Full title: A Systematic Approach for Soft Sensor Development

Authors: Lin, Bao; Recke, Bodil; Renaudat, Philippe; Knudsen, Jørgen; Jørgensen, Sten Bay; id_orcid 0000-0002-3179-972X

Year: 2007

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e1275c06-bc14-400c-9e61-ec01ae699504

Thesis Prediction of intensified ethanol fermentation of sugarcane using a deep learning soft sensor and process analytical technology

C. Rivera, Elmer; Yamakawa, Celina K.; id_orcid 0000-0003-2394-0364 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Prediction of intensified ethanol fermentation of sugarcane using a deep learning soft sensor and process analytical technology

Authors: C. Rivera, Elmer; Yamakawa, Celina K.; id_orcid 0000-0003-2394-0364; Rossell, Carlos E.V.; Nolasco Jr., Jonas; Kwon, Hyun J.

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c8c36853-d297-4cb5-977c-2ecd4c99300d

Thesis Application of Multivariate Analysis Tools to Industrial Scale Fermentation Data

Mears, Lisa; Nørregård, Rasmus; Stocks, Stuart M. et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Application of Multivariate Analysis Tools to Industrial Scale Fermentation Data

Authors: Mears, Lisa; Nørregård, Rasmus; Stocks, Stuart M.; Albæk, Mads O.; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Villez, Kris

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d6574e30-e890-4fdf-aa5a-4378505d80bc

Madsen, Julie Østerby; Topalian, Sebastian Olivier Nymann; id_orcid 0000-0002-2339-2073 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f7fda0c3-ae47-4d1e-94d7-439cc701affe

Thesis Digital Twins in Pilot Scale Fermentation: Non-Linear State Estimation for Improving Induction Timing

Stevnsborg, Mads; Selle, Kurt; Barton, Ryan et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Digital Twins in Pilot Scale Fermentation: Non-Linear State Estimation for Improving Induction Timing

Authors: Stevnsborg, Mads; Selle, Kurt; Barton, Ryan; Prado-Rubio, Oscar A.; Gargalo, Carina; id_orcid 0000-0002-8740-9591; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Gilleskie, Gary; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/df2addff-16df-4cf6-97e3-e7af790bd790

Thesis Applying an MPC algorithm to the dissolved oxygen level of an intermittent fed-batch process

Pably, P.; Huusom, J. K.; id_orcid 0000-0002-1367-7235 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Applying an MPC algorithm to the dissolved oxygen level of an intermittent fed-batch process

Authors: Pably, P.; Huusom, J. K.; id_orcid 0000-0002-1367-7235; Kager, J.; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e5bf89bb-2803-4e21-a9e6-46f1fe8b45c3

Thesis Online estimation of changing metabolic capacities in continuous Corynebacterium glutamicum cultivations growing on a complex sugar mixture

Sinner, Peter; Stiegler, Marlene; Goldbeck, Oliver et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Online estimation of changing metabolic capacities in continuous Corynebacterium glutamicum cultivations growing on a complex sugar mixture

Authors: Sinner, Peter; Stiegler, Marlene; Goldbeck, Oliver; Seibold, Gerd M.; id_orcid 0000-0002-9823-8134; Herwig, Christoph; Kager, Julian; id_orcid 0000-0001-7274-6678

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e1d47952-5939-40df-b5d8-a033a58e8745

Thesis Multi-function microfluidic platform for sensor integration

Fernandes, Ana C.; Semenova, Daria; Panjan, Peter et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Multi-function microfluidic platform for sensor integration

Authors: Fernandes, Ana C.; Semenova, Daria; Panjan, Peter; Sesay, Adama M.; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Krühne, Ulrich; id_orcid 0000-0001-7774-7442

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/eaed4eb0-30eb-4527-b02f-072563b02e0f

Thesis Supervision of Fed-Batch Fermentations

Gregersen, Lars; Jørgensen, Sten Bay; id_orcid 0000-0002-3179-972X · 1999 · Technical University of Denmark (DTU) · DOI

Full title: Supervision of Fed-Batch Fermentations

Authors: Gregersen, Lars; Jørgensen, Sten Bay; id_orcid 0000-0002-3179-972X

Year: 1999

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f3f93564-ae58-4d1e-8dab-11a3c1db50b6

Thesis Applying mechanistic models in bioprocess development.

Lencastre Fernandes, Rita; Bodla, Vijaya Krishna; Carlquist, Magnus et al. · 2013 · Technical University of Denmark (DTU) · DOI

Full title: Applying mechanistic models in bioprocess development.

Authors: Lencastre Fernandes, Rita; Bodla, Vijaya Krishna; Carlquist, Magnus; Heins, Anna-Lena; Eliasson Lantz, Anna; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist V; id_orcid 0000-0002-0364-1773

Year: 2013

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/fe2c6796-3008-4384-b8ce-953dce98e3d9

Thesis Introducing process analytical technology (PAT) in filamentous cultivation process development: comparison of advanced online sensors for biomass measurement

Rønnest, Nanna Petersen; Stocks, Stuart M.; Eliasson Lantz, Anna et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: Introducing process analytical technology (PAT) in filamentous cultivation process development: comparison of advanced online sensors for biomass measurement

Authors: Rønnest, Nanna Petersen; Stocks, Stuart M.; Eliasson Lantz, Anna; Gernaey, Krist; id_orcid 0000-0002-0364-1773

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f97a90b9-0fc6-409d-9360-d33ff5d591c0

Thesis Multivariate Analysis of Industrial Scale Fermentation Data

Mears, Lisa; Nørregård, Rasmus; Stocks, Stuart M. et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Multivariate Analysis of Industrial Scale Fermentation Data

Authors: Mears, Lisa; Nørregård, Rasmus; Stocks, Stuart M.; Albæk, Mads O.; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Villez, Kris

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f598e3df-5a71-4514-9a90-23fb7b6ef399

Thesis A low-cost, multiplexable, automated flow cytometry procedure for the characterization of microbial stress dynamics in bioreactors

Brognaux, Alison; Han, Shanshan; Sørensen, Søren Johannes et al. · 2013 · University of Copenhagen · DOI

Full title: A low-cost, multiplexable, automated flow cytometry procedure for the characterization of microbial stress dynamics in bioreactors

Authors: Brognaux, Alison; Han, Shanshan; Sørensen, Søren Johannes; Lebeau, Frederic; Thonart, Philippe; Delvigne, Frank

Year: 2013

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/efa84723-8a16-4ea4-9f55-e16e922cef8f

Thesis Novel strategies for control of fermentation processes

Mears, Lisa · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Novel strategies for control of fermentation processes

Authors: Mears, Lisa

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f0e5a504-744d-491b-be8f-d469c1d71bca

Thesis Model Predictive Control of dissolved oxygen level in an intermittent fed-batch process – Simulation & Application

Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Model Predictive Control of dissolved oxygen level in an intermittent fed-batch process – Simulation & Application

Authors: Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235; Kager, Julian; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/fe55fd04-e378-4860-b304-b314688d1774

Thesis Monitoring the convection coefficient in fermentative processes using numerical methods

da Paz, Priscila Marques [UNESP]; de Oliveira, Juliana [UNESP] · 2018 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Monitoring the convection coefficient in fermentative processes using numerical methods

Authors: da Paz, Priscila Marques [UNESP]; de Oliveira, Juliana [UNESP]

Year: 2018

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1007/s00449-018-1903-6

Thesis Thin film, wireless, flexible sensing system for real-time cell-culture monitoring

Lodhi, Isha · 2020 · Georgia Institute of Technology · DOI

Full title: Thin film, wireless, flexible sensing system for real-time cell-culture monitoring

Authors: Lodhi, Isha

Year: 2020

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/63568

Thesis A Multivariate Calibration Procedure for UV/VIS Spectrometric Monitoring of BHK-21 Cell Metabolism and Growth

Leme, Jaci; Fernández Núñez, Eutimio Gustavo [UNESP]; Parizotto, Leticia de Almeida et al. · 2014 · Universidade Estadual Paulista (UNESP) · DOI

Full title: A Multivariate Calibration Procedure for UV/VIS Spectrometric Monitoring of BHK-21 Cell Metabolism and Growth

Authors: Leme, Jaci; Fernández Núñez, Eutimio Gustavo [UNESP]; Parizotto, Leticia de Almeida; Chagas, Wagner Antonio; Santos, Erica Salla dos; Prestia Caricati, Aline Tojeira; Rezende, Alexandre Goncalves de; Vale da Costa, Bruno Labate; Ventini Monteiro, Daniela Cristina; Lopes Boldorini, Vera Lucia; Calil Jorge, Soraia Attie; Astray, Renato Mancini; Pereira, Carlos Augusto; Caricati, Celso Pereira; Tonso, Aldo

Year: 2014

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1002/btpr.1847

Thesis Brewing process optimization by artificial neural network and evolutionary algorithm approach

Takahashi, Maria Beatriz [UNESP]; Coelho de Oliveira, Henrique [UNESP]; Fernández Núñez, Eutimio Gustavo et al. · 2019 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Brewing process optimization by artificial neural network and evolutionary algorithm approach

Authors: Takahashi, Maria Beatriz [UNESP]; Coelho de Oliveira, Henrique [UNESP]; Fernández Núñez, Eutimio Gustavo; Rocha, José Celso [UNESP]

Year: 2019

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1111/jfpe.13103

Thesis A microfluidic platform for in situ mass spectrometry of intracellular biomarkers

Culberson, Austin L. · 2024 · Georgia Institute of Technology · DOI

Full title: A microfluidic platform for in situ mass spectrometry of intracellular biomarkers

Authors: Culberson, Austin L.

Year: 2024

Venue: Georgia Institute of Technology

DOI: https://hdl.handle.net/1853/75072

Thesis The Dynamic Sampling Platform (DSP) for Real-time Bioreactor Monitoring

Chilmonczyk, Mason A. · 2021 · Georgia Institute of Technology · DOI

Full title: The Dynamic Sampling Platform (DSP) for Real-time Bioreactor Monitoring

Authors: Chilmonczyk, Mason A.

Year: 2021

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/64969

Thesis Digital Twin Design and Autonomous Control of Bioreactor Systems for Human Immune Cell Expansion

Kanwar, Bharat · 2024 · Georgia Institute of Technology · DOI

Full title: Digital Twin Design and Autonomous Control of Bioreactor Systems for Human Immune Cell Expansion

Authors: Kanwar, Bharat

Year: 2024

Venue: Georgia Institute of Technology

DOI: https://hdl.handle.net/1853/75727

Thesis Artificial intelligence approach based on near-infrared spectral data for monitoring of solid-state fermentation

Barchi, Augusto Cesar [UNESP]; Ito, Shuri [UNESP]; Escaramboni, Bruna [UNESP] et al. · 2018 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Artificial intelligence approach based on near-infrared spectral data for monitoring of solid-state fermentation

Authors: Barchi, Augusto Cesar [UNESP]; Ito, Shuri [UNESP]; Escaramboni, Bruna [UNESP]; Oliva Neto, Pedro de [UNESP]; Herculano, Rondinelli Donizetti [UNESP]; Romeiro Miranda, Matheus Carlos [UNESP]; Passalia, Felipe Jose [UNESP]; Rocha, Jose Celso [UNESP]; Fernandez Nunez, Eutimio Gustavo [UNESP]

Year: 2018

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1016/j.procbio.2016.07.017

Thesis Process development and process analytical technology integration for cell therapy manufacturing

Wang, Bryan · 2025 · Georgia Institute of Technology · DOI

Full title: Process development and process analytical technology integration for cell therapy manufacturing

Authors: Wang, Bryan

Year: 2025

Venue: Georgia Institute of Technology

DOI: https://hdl.handle.net/1853/76777

Thesis A Novel Semi-supervised Two-dimensional Dynamic Soft Sensor for Quality Prediction in Batch Processes

Zhao, Ling; Zhu, Jinlin; Zhang, Zheng et al. · 2023 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: A Novel Semi-supervised Two-dimensional Dynamic Soft Sensor for Quality Prediction in Batch Processes

Authors: Zhao, Ling; Zhu, Jinlin; Zhang, Zheng; Xie, Zhenping; Gao, Furong

Year: 2023

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-135618

Thesis Wireless Biosensor System Electronics For Real-Time Monitoring of Bioreactor Cell Culture Properties

Rafay, Mohammed · 2022 · Georgia Institute of Technology · DOI

Full title: Wireless Biosensor System Electronics For Real-Time Monitoring of Bioreactor Cell Culture Properties

Authors: Rafay, Mohammed

Year: 2022

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/66614

Thesis Improved calibration investigation using phase-wise local and cumulative quality interpretation and prediction

Zhao, Chunhui; Wang, Fuh; Gao, Furong · 2009 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Improved calibration investigation using phase-wise local and cumulative quality interpretation and prediction

Authors: Zhao, Chunhui; Wang, Fuh; Gao, Furong

Year: 2009

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-18128

Thesis Data-Driven Batch-End Quality Modeling and Monitoring Based on Optimized Sparse Partial Least Squares

Jiang, Qingchao; Yan, Xuefeng; Yi, Hui et al. · 2020 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Data-Driven Batch-End Quality Modeling and Monitoring Based on Optimized Sparse Partial Least Squares

Authors: Jiang, Qingchao; Yan, Xuefeng; Yi, Hui; Gao, Furong

Year: 2020

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-103494

Thesis Mesenchymal Stromal Cell Manufacturing for the Identification of Immunomodulatory Properties In Acute Respiratory Distress Syndrome (ARDS)

Jimenez, Angela C. · 2025 · Georgia Institute of Technology · DOI

Full title: Mesenchymal Stromal Cell Manufacturing for the Identification of Immunomodulatory Properties In Acute Respiratory Distress Syndrome (ARDS)

Authors: Jimenez, Angela C.

Year: 2025

Venue: Georgia Institute of Technology

DOI: https://hdl.handle.net/1853/77701

Thesis Design and monitoring of crystallization processes with multiple solid-state forms : temperature cycling induced deracemization with concurrent degradation and a soft sensor for quantifying the mass fractions of crystalline protein solid-state forms

Lo, Po Sang · 2024 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Design and monitoring of crystallization processes with multiple solid-state forms : temperature cycling induced deracemization with concurrent degradation and a soft sensor for quantifying the mass fractions of crystalline protein solid-state forms

Authors: Lo, Po Sang

Year: 2024

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-150226

Thesis Collaborative Multiple Players to Address Label Sparsity in Quality Prediction of Batch Processes

Zhao, Ling; Zhang, Zheng; Zhu, Jinlin et al. · 2024 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Collaborative Multiple Players to Address Label Sparsity in Quality Prediction of Batch Processes

Authors: Zhao, Ling; Zhang, Zheng; Zhu, Jinlin; Wang, Hongchao; Xie, Zhenping

Year: 2024

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-138218

Thesis Two-Dimensional Statistical Pattern Analysis for Effective Modeling and Monitoring of Limited Batch Process Data in Food Industry

Zhu, Jinlin; Zhang, Zheng · 2024 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Two-Dimensional Statistical Pattern Analysis for Effective Modeling and Monitoring of Limited Batch Process Data in Food Industry

Authors: Zhu, Jinlin; Zhang, Zheng

Year: 2024

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-143851

Thesis Investigation on algorithms for determination of chemical concentration by near infrared Raman spectroscopy

Yau, O.L.; Yau, S.F. · 1999 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Investigation on algorithms for determination of chemical concentration by near infrared Raman spectroscopy

Authors: Yau, O.L.; Yau, S.F.

Year: 1999

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-25776

Thesis Semi-supervised regression based on Representation Learning for fermentation processes

Liu, Jing; Wang, Junxian; Xia, Jianye et al. · 2024 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Semi-supervised regression based on Representation Learning for fermentation processes

Authors: Liu, Jing; Wang, Junxian; Xia, Jianye; Lv, Fengfeng; Wu, Dawei

Year: 2024

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-140883

Thesis The use of biosensors in control of fed-batch processes - Opportunities and limitations

Renneberg, R.; Barford, JP; Tse, SMA · 1998 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: The use of biosensors in control of fed-batch processes - Opportunities and limitations

Authors: Renneberg, R.; Barford, JP; Tse, SMA

Year: 1998

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-44080

Thesis Improved Nonlinear Quality Estimation for Multiphase Batch Processes Based on Relevance Vector Machine with Neighborhood Component Variable Selection

Zhu, Jinlin CBME; Gao, Furong · 2018 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Improved Nonlinear Quality Estimation for Multiphase Batch Processes Based on Relevance Vector Machine with Neighborhood Component Variable Selection

Authors: Zhu, Jinlin CBME; Gao, Furong

Year: 2018

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-89216

Thesis Multivariate statistical monitoring of two-dimensional dynamic batch processes utilizing non-Gaussian information

Yao, Yuan; Chen, Tao; Gao, Furong · 2010 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Multivariate statistical monitoring of two-dimensional dynamic batch processes utilizing non-Gaussian information

Authors: Yao, Yuan; Chen, Tao; Gao, Furong

Year: 2010

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-39867

Thesis Gaussian Process Regression and Bayesian Inference Based Operating Performance Assessment for Multiphase Batch Processes

Liu, Yan CBE; Wang, Xiaojun; Wang, Fuli et al. · 2018 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Gaussian Process Regression and Bayesian Inference Based Operating Performance Assessment for Multiphase Batch Processes

Authors: Liu, Yan CBE; Wang, Xiaojun; Wang, Fuli; Gao, Furong

Year: 2018

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-90877

Thesis Computer-aided chemical engineering research advances in precision fermentation

Vinestock, Tom; Short, Michael; Ward, Keeran et al. · 2024 · Imperial College London · DOI

Full title: Computer-aided chemical engineering research advances in precision fermentation

Authors: Vinestock, Tom; Short, Michael; Ward, Keeran; Guo, Miao

Year: 2024

Venue: Imperial College London

DOI: http://dx.doi.org/10.1016/j.cofs.2024.101196

Thesis Application of Raman spectroscopy to dynamic binding capacity analysis

Beattie, James W; Rowland-Jones, Ruth C; Farys, Monika et al. · 2024 · Imperial College London · DOI

Full title: Application of Raman spectroscopy to dynamic binding capacity analysis

Authors: Beattie, James W; Rowland-Jones, Ruth C; Farys, Monika; Bettany, Hamish; Hilton, David; Kazarian, Sergei G; Byrne, Bernadette

Year: 2024

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/37908083

Thesis In situ FRET Biosensors for the in vivo measurement of important metabolites during cell culture

Behjousiar, Alireza · 2015 · Imperial College London · DOI

Full title: In situ FRET Biosensors for the in vivo measurement of important metabolites during cell culture

Authors: Behjousiar, Alireza

Year: 2015

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/24852

Thesis Systematic development of predictive mathematical models for animal cell cultures

Kontoravdi, Cleo; Pistikopoulos, Efstratios N; Mantalaris, Athanasios · 2014 · Imperial College London · DOI

Full title: Systematic development of predictive mathematical models for animal cell cultures

Authors: Kontoravdi, Cleo; Pistikopoulos, Efstratios N; Mantalaris, Athanasios

Year: 2014

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000279658700003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Fluorescence diffuse optical monitoring of bioreactors: a hybrid deep learning and model-based approach for tomography

Cao, Jiaming; Gorecki, Jon; Dale, Robin et al. · 2024 · Imperial College London · DOI

Full title: Fluorescence diffuse optical monitoring of bioreactors: a hybrid deep learning and model-based approach for tomography

Authors: Cao, Jiaming; Gorecki, Jon; Dale, Robin; Redwood-Sawyerr, Chileab; Kontoravdi, Cleo; Polizzi, Karen; Rowlands, Christopher J; Dehghani, Hamid

Year: 2024

Venue: Imperial College London

DOI: http://dx.doi.org/10.1364/boe.529884

Thesis Whole-cell Escherichia coli lactate biosensor for monitoring mammalian cell cultures during biopharmaceutical production

Goers, L; Ainsworth, C; Goey, CH et al. · 2017 · Imperial College London · DOI

Full title: Whole-cell Escherichia coli lactate biosensor for monitoring mammalian cell cultures during biopharmaceutical production

Authors: Goers, L; Ainsworth, C; Goey, CH; Kontoravdi; Freemont, PS; Polizzi, KM

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/44165

Thesis Fabrication and Characterization of Fluorescent Oxygen and pH Sensor Films for Real-Time In-Situ Cell Culture Monitoring on Digital Microfluidic (DMF) Platforms

Qiu, Wenting; Nagl, Stefan · 2018 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Fabrication and Characterization of Fluorescent Oxygen and pH Sensor Films for Real-Time In-Situ Cell Culture Monitoring on Digital Microfluidic (DMF) Platforms

Authors: Qiu, Wenting; Nagl, Stefan

Year: 2018

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-96882

Thesis In-column ATR-FTIR spectroscopy to monitor affinity chromatography purification of monoclonal antibodies

Boulet-Audet, M; Kazarian, SG; Byrne, B · 2016 · Imperial College London · DOI

Full title: In-column ATR-FTIR spectroscopy to monitor affinity chromatography purification of monoclonal antibodies

Authors: Boulet-Audet, M; Kazarian, SG; Byrne, B

Year: 2016

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/34378

Thesis Novel in vivo biosensors for monitoring of mammalian cell cultures

Goers, Lisa · 2017 · Imperial College London · DOI

Full title: Novel in vivo biosensors for monitoring of mammalian cell cultures

Authors: Goers, Lisa

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/44463

Thesis Sense and sensitivity in bioprocessing-detecting cellular metabolites with biosensors.

Dekker, L; Polizzi, KM · 2017 · Imperial College London · DOI

Full title: Sense and sensitivity in bioprocessing-detecting cellular metabolites with biosensors.

Authors: Dekker, L; Polizzi, KM

Year: 2017

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/28609710

Thesis Characterisation of pH and Glucose Sensors for use in Cell Culture

Singhal, Suket; Singhal, Suket · 2009 · Imperial College London · DOI

Full title: Characterisation of pH and Glucose Sensors for use in Cell Culture

Authors: Singhal, Suket; Singhal, Suket

Year: 2009

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/4352

Thesis Real-time online in situ monitoring and statistical design strategies for haematopoietic stem cell bioprocessing

Lim, Mayasari; Lim, Mayasari · 2010 · Imperial College London · DOI

Full title: Real-time online in situ monitoring and statistical design strategies for haematopoietic stem cell bioprocessing

Authors: Lim, Mayasari; Lim, Mayasari

Year: 2010

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/4408

Thesis In silico dynamic optimisation studies for batch/fed-batch mammalian cell suspension cultures producing biopharmaceuticals

Lam, Ming-Chi · 2017 · Imperial College London · DOI

Full title: In silico dynamic optimisation studies for batch/fed-batch mammalian cell suspension cultures producing biopharmaceuticals

Authors: Lam, Ming-Chi

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/45465

Thesis In Situ Monitoring of Intracellular Glucose and Glutamine in CHO Cell Culture

Behjousiar, A; Kontoravdi, C; Polizzi, KM · 2014 · Imperial College London · DOI

Full title: In Situ Monitoring of Intracellular Glucose and Glutamine in CHO Cell Culture

Authors: Behjousiar, A; Kontoravdi, C; Polizzi, KM

Year: 2014

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/14483

Thesis Online quantitative monitoring of live cell engineered cartilage growth using diffuse fiber-optic Raman spectroscopy

Bergholt, M; Albro, M; Stevens, MM · 2017 · Imperial College London · DOI

Full title: Online quantitative monitoring of live cell engineered cartilage growth using diffuse fiber-optic Raman spectroscopy

Authors: Bergholt, M; Albro, M; Stevens, MM

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/49140

Thesis Identification and quantification of VOCs by Proton Transfer Reaction Time of Flight Mass Spectrometry: an experimental workflow for the optimization of specificity, sensitivity and accuracy

Romano, A; Hanna, George · 2018 · Imperial College London · DOI

Full title: Identification and quantification of VOCs by Proton Transfer Reaction Time of Flight Mass Spectrometry: an experimental workflow for the optimization of specificity, sensitivity and accuracy

Authors: Romano, A; Hanna, George

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/56097

Thesis Synergising stoichiometric modelling with artificial neural networks to predict antibody glycosylation patterns in Chinese hamster ovary cells

Antonakoudis, Athanasios; Strain, Benjamin; Barbosa, Rodrigo et al. · 2021 · Imperial College London · DOI

Full title: Synergising stoichiometric modelling with artificial neural networks to predict antibody glycosylation patterns in Chinese hamster ovary cells

Authors: Antonakoudis, Athanasios; Strain, Benjamin; Barbosa, Rodrigo; Jimenez del Val, Ioscani; Kontoravdi, Kleio

Year: 2021

Venue: Imperial College London

DOI: https://www.sciencedirect.com/science/article/pii/S0098135421002490?via%3Dihub

Thesis Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch

Gangadharan, Nishanthi · 2023 · University of Cambridge · DOI

Full title: Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch

Authors: Gangadharan, Nishanthi

Year: 2023

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/358135

Thesis Non-invasive real time monitoring of yeast volatilome by PTR-ToF-MS

Khomenko, Iuliia; Stefanini, Irene; Cappellin, Luca et al. · 2017 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Non-invasive real time monitoring of yeast volatilome by PTR-ToF-MS

Authors: Khomenko, Iuliia; Stefanini, Irene; Cappellin, Luca; Cappelletti, Valentina; Franceschi, Pietro; Cavalieri, Duccio; Märk, Tilmann D.; Biasioli, Franco

Year: 2017

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/191304

Thesis Tailor-made PAT platform for safe syngas fermentations in batch, fed-batch and chemostat mode with Rhodospirillum rubrum

Karmann, Stephanie; Follonier, Stéphanie; Egger, Daniel et al. · 2017 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Tailor-made PAT platform for safe syngas fermentations in batch, fed-batch and chemostat mode with Rhodospirillum rubrum

Authors: Karmann, Stephanie; Follonier, Stéphanie; Egger, Daniel; Hebel, Dirk; Panke, Sven; Manfred, Zinn

Year: 2017

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/161249

Thesis Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing

Williams, Thomas; Sanches, Rui; Blanchard-Emmerson, Greg et al. · 2023 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing

Authors: Williams, Thomas; Sanches, Rui; Blanchard-Emmerson, Greg; Watts, Samuel; Davies, Lee; Knevelman, Carol; McCloskey, Laura; Jones, Peter; Mitrophanous, Kyriacos; Miskin, James; Dikicioglu, Duygu

Year: 2023

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/596703

Thesis Combining Mechanistic Modeling and Raman Spectroscopy for Monitoring Antibody Chromatographic Purification

Feidl, Fabian; Garbellini, Simone; Luna, Martin F. et al. · 2019 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Combining Mechanistic Modeling and Raman Spectroscopy for Monitoring Antibody Chromatographic Purification

Authors: Feidl, Fabian; Garbellini, Simone; Luna, Martin F.; Vogg, Sebastian; id_orcid0000-0002-6890-6744; Souquet, Jonathan; Broly, Hervé; Morbidelli, Massimo; Butté, Alessandro

Year: 2019

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/378842

Thesis Bioprocess in-line monitoring using Raman spectroscopy and Indirect Hard Modeling (IHM): A simple calibration yields a robust model

Müller, David Heinrich; Flake, Carsten; Brands, Thorsten et al. · 2023 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Bioprocess in-line monitoring using Raman spectroscopy and Indirect Hard Modeling (IHM): A simple calibration yields a robust model

Authors: Müller, David Heinrich; Flake, Carsten; Brands, Thorsten; Koß, Hans-Jürgen

Year: 2023

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/614575

Thesis Automated online flow cytometry advances microalgal ecosystem management as in situ, high-temporal resolution monitoring tool

Haberkorn, Iris; Off, Cosima L.; Besmer, Michael D. et al. · 2021 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Automated online flow cytometry advances microalgal ecosystem management as in situ, high-temporal resolution monitoring tool

Authors: Haberkorn, Iris; Off, Cosima L.; Besmer, Michael D.; Buchmann, Leandro; id_orcid0000-0002-3601-4645; Mathys, Alexander; id_orcid0000-0002-3601-4645

Year: 2021

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/470693

Thesis Estratègies d'operació en el procés de producció de proteïnes heteròlogues en Pichia pastoris: aplicació de tècniques de monitorització i control

Ramon Real, Ramon · 2011 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Estratègies d'operació en el procés de producció de proteïnes heteròlogues en Pichia pastoris: aplicació de tècniques de monitorització i control

Authors: Ramon Real, Ramon

Year: 2011

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://www.tdx.cat/TDX-0121110-092632

Thesis Accelerated Bioprocess Development of Endopolygalacturonase-Production with Saccharomyces cerevisiae Using Multivariate Prediction in a 48 Mini-Bioreactor Automated Platform

Sawatzki, Annina; Hans, Sebastian; Narayanan, Harini et al. · 2018 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Accelerated Bioprocess Development of Endopolygalacturonase-Production with Saccharomyces cerevisiae Using Multivariate Prediction in a 48 Mini-Bioreactor Automated Platform

Authors: Sawatzki, Annina; Hans, Sebastian; Narayanan, Harini; Haby, Benjamin; Krausch, Niels; Sokolov, Michael; Glauche, Florian; Riedel, Sebastian L.; Neubauer, Peter; Cruz Bournazou, Mariano Nicolas; id_orcid0000-0001-9461-4414

Year: 2018

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/364323

Thesis Monitoring parallel robotic cultivations with online multivariate analysis

Hans, Sebastian; Ulmer, Christian; Narayanan, Harini et al. · 2020 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Monitoring parallel robotic cultivations with online multivariate analysis

Authors: Hans, Sebastian; Ulmer, Christian; Narayanan, Harini; Brautaset, Trygve; Krausch, Niels; id_orcid0000-0003-2325-6001; Neubauer, Peter; Schäffl, Irmgard; Sokolov, Michael; Cruz Bournazou, Mariano Nicolas; id_orcid0000-0003-2325-6001

Year: 2020

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/418739

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Probeless non-invasive near-infrared spectroscopic bioprocess monitoring using microspectrometer technology

Zimmerleiter, Robert; Kager, Julian; Nikzad‐Langerodi, Ramin et al. · 2019

Full title: Probeless non-invasive near-infrared spectroscopic bioprocess monitoring using microspectrometer technology

Authors: Zimmerleiter, Robert; Kager, Julian; Nikzad‐Langerodi, Ramin; Berezhinskiy, Vladimir; Westad, Frank; Herwig, Christoph; Brandstetter, Markus

DOI: https://doi.org/10.1007/s00216-019-02227-w

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A novel toolbox for E. coli lysis monitoring

Rajamanickam, Vignesh; Wurm, David Johannes; Slouka, Christoph et al. · 2016

Full title: A novel toolbox for E. coli lysis monitoring

Authors: Rajamanickam, Vignesh; Wurm, David Johannes; Slouka, Christoph; Herwig, Christoph; Spadiut, Oliver

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The role of Raman spectroscopy in biopharmaceuticals from development to manufacturing.

Esmonde-White, Karen A; Cuellar, Maryann; Lewis, Ian R · 2022

Full title: The role of Raman spectroscopy in biopharmaceuticals from development to manufacturing.

Authors: Esmonde-White, Karen A; Cuellar, Maryann; Lewis, Ian R

DOI: https://doi.org/10.1007/s00216-021-03727-4

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Biopharmaceutical analysis — current analytical challenges, limitations, and perspectives

Cunha, Diana R; Garcia, M. Beatriz Q.; Segundo, Marcela A. · 2025

Full title: Biopharmaceutical analysis — current analytical challenges, limitations, and perspectives

Authors: Cunha, Diana R; Garcia, M. Beatriz Q.; Segundo, Marcela A.

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Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra

Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn et al. · 2021

Authors: Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn; Mastrobattista, Enrico; Yamabhai, Montarop

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Bioanalytical Reviews

Quaranta, Michela; Borisov, Sergey M.; Klimant, Ingo et al. · 2016

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A process analyzer assembly for real-time automated near-infrared, Raman, and proton nuclear magnetic resonance spectroscopic monitoring enhanced by heterocovariance spectroscopy and chemometry applied to a Schiff base formation

Wilbert, Dominik; Voigt, Melanie; Jaeger, Martin · 2025

Authors: Wilbert, Dominik; Voigt, Melanie; Jaeger, Martin

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Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing.

Esmonde-White, Karen A; Cuellar, Maryann; Uerpmann, Carsten et al. · 2017

Full title: Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing.

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A robust flow cytometry-based biomass monitoring tool enables rapid at-line characterization of S. cerevisiae physiology during continuous bioprocessing of spent sulfite liquor

Vees, Charlotte Anne; Veiter, Lukas; Sax, Fritz et al. · 2020

Full title: A robust flow cytometry-based biomass monitoring tool enables rapid at-line characterization of S. cerevisiae physiology during continuous bioprocessing of spent sulfite liquor

Authors: Vees, Charlotte Anne; Veiter, Lukas; Sax, Fritz; Herwig, Christoph; Pflügl, Stefan

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Becoming fully circular facilitated by PAT

Eifert, Tobias; Gerlach, Martin; Dahlmann, Katharina et al. · 2025

Full title: Becoming fully circular facilitated by PAT

Authors: Eifert, Tobias; Gerlach, Martin; Dahlmann, Katharina; Lendl, Bernhard; Rädle, Matthias; Jaeger, Martin

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Monitoring of ultra- and diafiltration processes by Kalman-filtered Raman measurements

Rolinger, Laura; Hubbuch, Jürgen; Rüdt, Matthias · 2023

Full title: Monitoring of ultra- and diafiltration processes by Kalman-filtered Raman measurements

Authors: Rolinger, Laura; Hubbuch, Jürgen; Rüdt, Matthias

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Metrological traceability in process analytical technologies and point-of-need technologies for food safety and quality control: not a straightforward issue

Mattarozzi, Monica; Laski, Eleni; Bertucci, Alessandro et al. · 2022

Full title: Metrological traceability in process analytical technologies and point-of-need technologies for food safety and quality control: not a straightforward issue

Authors: Mattarozzi, Monica; Laski, Eleni; Bertucci, Alessandro; Giannetto, Marco; Bianchi, Federica; Zoani, Claudia; Careri, Maria

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Micro simulated moving bed chromatography-mass spectrometry as a continuous on-line process analytical tool

Diehm, Juliane; Witting, Lennart; Kirschhöfer, Frank et al. · 2023

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Synthetic spectral libraries for Raman model calibration

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Comparison of different model-based observers for monitoring substrate and product concentrations in a Penicillium chrysogenum Fed-batch process

Berezhinskiy, Vladimir · 2019

Full title: Comparison of different model-based observers for monitoring substrate and product concentrations in a Penicillium chrysogenum Fed-batch process

Authors: Berezhinskiy, Vladimir

DOI: https://doi.org/10.34726/hss.2019.63131

Paper

Moleküler Spektroskopinin Temel Prensipleri ve Uygulamaları

Bayraktutan, Tuğba; Akın, İlker; Demirel, Serkan et al. · 2026

Full title: Moleküler Spektroskopinin Temel Prensipleri ve Uygulamaları

Authors: Bayraktutan, Tuğba; Akın, İlker; Demirel, Serkan; Koçyiğit, Adem; Selimoğlu, Faysal; Ayhan, Muhammed Emre; Ayhan, Muhammed Emre; Yiğit, Aybek

DOI: https://doi.org/10.37609/akya.3978

Paper

Differentiation of bacterial strains by means of surface enhanced FT-Raman spectroscopy

Kairyte, Kristina; Lukšiené, Živilė; Pučetaitė, Milda et al. · 2012

Full title: Differentiation of bacterial strains by means of surface enhanced FT-Raman spectroscopy

Authors: Kairyte, Kristina; Lukšiené, Živilė; Pučetaitė, Milda; Šablinskas, Valdas

DOI: https://doi.org/10.3952/physics.v52i3.2480

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Uncertainty Quantification Using Ensemble Learning and Monte Carlo Sampling for Performance Prediction and Monitoring in Cell Culture Processes

Khuat, Thanh Tung; Bassett, Robert; Otte, Ellen et al. · 2025

Full title: Uncertainty Quantification Using Ensemble Learning and Monte Carlo Sampling for Performance Prediction and Monitoring in Cell Culture Processes

Authors: Khuat, Thanh Tung; Bassett, Robert; Otte, Ellen; Gabryś, Bogdan

DOI: https://doi.org/10.1002/jrs.6808

Paper

Development and characterisation of a new fluorescence sensor for online monitoring of bioprocesses

König, Jan Christoph; Steinwedel, Tobias; Solle, Dörte et al. · 2018

Full title: Development and characterisation of a new fluorescence sensor for online monitoring of bioprocesses

Authors: König, Jan Christoph; Steinwedel, Tobias; Solle, Dörte; Lindner, Patrick; Vries, Ingo de; Hentrop, Thorleif; Findeis, Michael; John, Gernot T.; Scheper, Thomas; Beutel, Sascha

DOI: https://doi.org/10.5194/jsss-7-461-2018

Paper

A customized stand-alone photometric Raman sensor applicable in explosive atmospheres: a proof-of-concept study

Nachtmann, Marcel; Keck, Shaun; Braun, Frank et al. · 2018

Full title: A customized stand-alone photometric Raman sensor applicable in explosive atmospheres: a proof-of-concept study

Authors: Nachtmann, Marcel; Keck, Shaun; Braun, Frank; Eckhardt, Hanns Simon; Mattolat, Christoph; Gretz, Norbert; Scholl, Stephan; Rädle, Matthias

DOI: https://doi.org/10.5194/jsss-7-543-2018

Paper

Machine Learning for Raman Spectroscopy-based Cyber-Marine Fish Biochemical Composition Analysis

Zhou, Yun; Chen, Gang; Xue, Bing et al. · 2024

Full title: Machine Learning for Raman Spectroscopy-based Cyber-Marine Fish Biochemical Composition Analysis

Authors: Zhou, Yun; Chen, Gang; Xue, Bing; Zhang, Jun; Rooney, Jeremy S.; Lagutin, Kirill; MacKenzie, Andrew; Gordon, Keith C.; Killeen, Daniel P.

DOI: https://doi.org/10.48550/arxiv.2409.19688

Paper

PAT and automation strategies for the process development of PEGylated proteins

Sanden, Adrian Simon Johannes Marius · 2020

Full title: PAT and automation strategies for the process development of PEGylated proteins

Authors: Sanden, Adrian Simon Johannes Marius

DOI: https://doi.org/10.5445/ir/1000122597

Paper

Simplified approaches to mid-infrared spectrometers calibration for bioprocess monitoring applications

Schenk, Jonas · 2007

Full title: Simplified approaches to mid-infrared spectrometers calibration for bioprocess monitoring applications

Authors: Schenk, Jonas

DOI: https://doi.org/10.5075/epfl-thesis-3917

Paper

Applications of Machine Learning in Biopharmaceutical Process Development and Manufacturing: Current Trends, Challenges, and Opportunities

Khuat, Thanh Tung; Bassett, Robert; Otte, Ellen et al. · 2023

Full title: Applications of Machine Learning in Biopharmaceutical Process Development and Manufacturing: Current Trends, Challenges, and Opportunities

Authors: Khuat, Thanh Tung; Bassett, Robert; Otte, Ellen; Grevis-James, Alistair; Gabryś, Bogdan

DOI: https://doi.org/10.48550/arxiv.2310.09991

Paper

Challenges and Emerging Technologies in Biomanufacturing of Monoclonal Antibodies (mAbs)

McDonnell, Susan; Principe, Raymon Floyd; Zamprognio, Maycou Soares et al. · 2022

Full title: Challenges and Emerging Technologies in Biomanufacturing of Monoclonal Antibodies (mAbs)

Authors: McDonnell, Susan; Principe, Raymon Floyd; Zamprognio, Maycou Soares; Whelan, Jessica

DOI: https://doi.org/10.5772/intechopen.108565

Paper

Soft Sensors for Biomass Monitoring during Low Cost Cellulase Production

C. Murugan · 2021

Full title: Soft Sensors for Biomass Monitoring during Low Cost Cellulase Production

Authors: C. Murugan

DOI: https://doi.org/10.5772/intechopen.96027

Paper

Process Analytical Technology (PAT) Model Lifecycle Management

McDermott, Larry · 2023

Full title: Process Analytical Technology (PAT) Model Lifecycle Management

Authors: McDermott, Larry

DOI: https://doi.org/10.56530/spectroscopy.pk3974j5

Paper

Mathematical decomposition and multivariate analysis applied to Raman imaging

Holahan, Erin C. · 2024

Full title: Mathematical decomposition and multivariate analysis applied to Raman imaging

Authors: Holahan, Erin C.

DOI: https://doi.org/10.58088/vn5d-v207

Paper

A Review on Progress and Potential of Machine Learning and AI in Pharmaceutical Development

Uriti, Sri Venkatesh · 2025

Full title: A Review on Progress and Potential of Machine Learning and AI in Pharmaceutical Development

Authors: Uriti, Sri Venkatesh

DOI: https://doi.org/10.69613/8pyky553

Paper

Untitled

· 2024

Full title: Untitled

DOI: https://doi.org/10.59551/ijhmp/25832069/4.1.2023

Paper

Spectroscopy as Process Analytical Technology for Preparative Protein Purification

Matthias Rüdt · 2019

Full title: Spectroscopy as Process Analytical Technology for Preparative Protein Purification

Authors: Matthias Rüdt

DOI: https://doi.org/10.5445/ir/1000089062

Paper

HPLC in the Era of Biopharma: Advances in Column Chemistry, Automation and Data Analytics

Bhavanam, Nagajyothi · 2025

Full title: HPLC in the Era of Biopharma: Advances in Column Chemistry, Automation and Data Analytics

Authors: Bhavanam, Nagajyothi

DOI: https://doi.org/10.61096/shareme.v4.iss4.2025.142-152

Paper

Quantitative analysis of glycerol concentration in red wine using Fourier transform infrared spectroscopy and chemometrics analysis

Joshi, Rahul; Joshi, Ritu; Amanah, Hanim Zuhrotul et al. · 2021

Full title: Quantitative analysis of glycerol concentration in red wine using Fourier transform infrared spectroscopy and chemometrics analysis

Authors: Joshi, Rahul; Joshi, Ritu; Amanah, Hanim Zuhrotul; Faqeerzada, Mohammad Akbar; Kumar, J.; Kim, Geonwoo; Baek, Insuck; Park, Eun-Sung; Masithoh, Rudiati Evi; Cho, Byoung–Kwan

DOI: https://doi.org/10.7744/kjoas.20210023

Paper

An environmental metabolomics study of the effect of abiotic substances on Pseudomonas putida by employing analytical techniques

Sayqal, Ali · 2017

Full title: An environmental metabolomics study of the effect of abiotic substances on Pseudomonas putida by employing analytical techniques

Authors: Sayqal, Ali

Paper

Advanced modelling, monitoring, and process control of bioconversion systems

Schmitt, Elliott · 2015

Full title: Advanced modelling, monitoring, and process control of bioconversion systems

Authors: Schmitt, Elliott

Paper

Modelling Bacterial Growth for Applying Photodynamic Therapy with Indocyanine Green

Nguyen, Minh Quang · 2018

Full title: Modelling Bacterial Growth for Applying Photodynamic Therapy with Indocyanine Green

Authors: Nguyen, Minh Quang

Paper

Assessment of Embryo Health and Circulating Tumor Cell Metabolism Using the Phasor-FLIM Approach

Ma, Ning · 2019

Full title: Assessment of Embryo Health and Circulating Tumor Cell Metabolism Using the Phasor-FLIM Approach

Authors: Ma, Ning

Paper

Effect of mesenchymal stem cell source on the molecular profile of extracellular vesicles for cell therapy

Pires, Filipa · 2019

Full title: Effect of mesenchymal stem cell source on the molecular profile of extracellular vesicles for cell therapy

Authors: Pires, Filipa

Paper

Development of Soft Sensors for Monitoring of Chinese Hamster Ovary Cell Processes

Ohadi, Seyed Kaveh · 2014

Full title: Development of Soft Sensors for Monitoring of Chinese Hamster Ovary Cell Processes

Authors: Ohadi, Seyed Kaveh

Paper

Real time monitoring of the extraction process of Tagitinin C according to the physicochemical properties of supercritical CO2 by means of optical fibers coupling a FT-IR spectrometer and a supercritical fluid extractor

Eric, Ziemons, · 2006

Authors: Eric, Ziemons,

Paper

Investigating Protein Modifications Using Vibrational Spectroscopy and Fluorescence Spectroscopy.

Brewster, Victoria L. · 2013

Full title: Investigating Protein Modifications Using Vibrational Spectroscopy and Fluorescence Spectroscopy.

Authors: Brewster, Victoria L.

Paper

Online Raman spectroscopy for bioprocess monitoring

Gil, Gustavo Adolfo · 2005

Full title: Online Raman spectroscopy for bioprocess monitoring

Authors: Gil, Gustavo Adolfo

Paper

Seleção de variáveis baseada na integração de ranking de importância SVD com métodos de aprendizagem de máquina

Brito, João B. G. · 2020

Full title: Seleção de variáveis baseada na integração de ranking de importância SVD com métodos de aprendizagem de máquina

Authors: Brito, João B. G.

Paper

Screening and Engineering Phenotypes using Big Data Systems Biology

Huttanus, Herbert M. · 2019

Full title: Screening and Engineering Phenotypes using Big Data Systems Biology

Authors: Huttanus, Herbert M.

Paper

Single cell analysis and quantitative modelling of ion concentrations and dielectric properties of Chinese hamster ovary cells

Fazelkhah, Azita · 2020

Full title: Single cell analysis and quantitative modelling of ion concentrations and dielectric properties of Chinese hamster ovary cells

Authors: Fazelkhah, Azita

Paper

Valorisation of olive mill solid waste through the production of volatile fatty acids within a biorefinery approach

Elena, Jiménez Páez, · 2025

Full title: Valorisation of olive mill solid waste through the production of volatile fatty acids within a biorefinery approach

Authors: Elena, Jiménez Páez,

Paper

Sol-gel-derived optical oxygen, pH and dissolved carbon dioxide sensors

Wencel, Dorota · 2008

Full title: Sol-gel-derived optical oxygen, pH and dissolved carbon dioxide sensors

Authors: Wencel, Dorota

Paper

Using Ft-Nir Spectroscopy To Automate Constant Sugar Concentration Fed-Batch Fermentations With Saccharomyces Cerevisiae: Effects On Cellular Viability And Kinetics Of Osmotic Stress Associated Metabolites

Frohman, Charles · 2013

Authors: Frohman, Charles

Paper

Untersuchung der Auswirkung verschiedener Umwelteinflüsse auf Mikroorganismen mittels ortsaufgelöster Raman-Spektroskopie

Münchberg, Ute · 2015

Full title: Untersuchung der Auswirkung verschiedener Umwelteinflüsse auf Mikroorganismen mittels ortsaufgelöster Raman-Spektroskopie

Authors: Münchberg, Ute

Thesis

Implementation of process analytical technology (PAT) systems in manufacturing processes of liquid formulations

Brouckaert, Davinia · 2017

Full title: Implementation of process analytical technology (PAT) systems in manufacturing processes of liquid formulations

Authors: Brouckaert, Davinia

DOI: https://biblio.ugent.be/publication/8540958

Thesis

Evaluation of accuracy dependence of Raman spectroscopic models on the ratio of calibration and validation points for non-invasive glucose sensing

Singh, Surya P; Mukherjee, Soumavo; Galindo, Luis H et al. · 2021

Full title: Evaluation of accuracy dependence of Raman spectroscopic models on the ratio of calibration and validation points for non-invasive glucose sensing

Authors: Singh, Surya P; Mukherjee, Soumavo; Galindo, Luis H; So, Peter TC; Dasari, Ramachandra Rao; Khan, Uzma Zubair; Kannan, Raghuraman; Upendran, Anandhi; Kang, Jeon Woong

DOI: https://hdl.handle.net/1721.1/135824

Thesis

Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing

Soenksen Martinez, Luis Ruben; Kassis, Timothy; Noh, Minkyun et al. · 2018

Full title: Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing

Authors: Soenksen Martinez, Luis Ruben; Kassis, Timothy; Noh, Minkyun; Griffith, Linda G; Trumper, David L

DOI: http://hdl.handle.net/1721.1/116892

Thesis

Industry 4.0 in Biomanufacturing: Predictive Real-Time Models Using Process Analytical Technology

Murr, Michaela · 2023

Full title: Industry 4.0 in Biomanufacturing: Predictive Real-Time Models Using Process Analytical Technology

Authors: Murr, Michaela

DOI: https://hdl.handle.net/1721.1/151710

Thesis

Chemometric techniques for multivariate calibration and their application in spectroscopic sensors

Ke, Wang · 2012

Full title: Chemometric techniques for multivariate calibration and their application in spectroscopic sensors

Authors: Ke, Wang

DOI: https://hdl.handle.net/10356/48640

Thesis

Analytical tools for monitoring and control of fermentation processes

Sundström, Heléne · 2007

Full title: Analytical tools for monitoring and control of fermentation processes

Authors: Sundström, Heléne

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4531

Thesis

An Investigation of Multivariate Process Control for Biomanufacturing

Lui, Christopher A. · 2022

Full title: An Investigation of Multivariate Process Control for Biomanufacturing

Authors: Lui, Christopher A.

DOI: https://hdl.handle.net/1721.1/139505

Thesis

PROCESS ANALYTICAL TECHNOLOGY APPROACHES FOR DAIRY INDUSTRY

STRANI, LORENZO · 2021

Full title: PROCESS ANALYTICAL TECHNOLOGY APPROACHES FOR DAIRY INDUSTRY

Authors: STRANI, LORENZO

DOI: http://hdl.handle.net/2434/814055

Thesis

Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis

Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Hong, Moo Sun · 2022

Full title: Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Authors: Hong, Moo Sun

DOI: https://hdl.handle.net/1721.1/138943

Thesis

Optical in-line biosensor for long-term continuous glucose monitoring and control in cell culture

Tric, Mircea · 2017

Full title: Optical in-line biosensor for long-term continuous glucose monitoring and control in cell culture

Authors: Tric, Mircea

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/23763/1/Dissertation%20Mircea%20Tric.pdf

Thesis

Preemptive variation reduction in biologic drug substance manufacturing

Güereca Valdivia, Ismael · 2024

Full title: Preemptive variation reduction in biologic drug substance manufacturing

Authors: Güereca Valdivia, Ismael

DOI: https://hdl.handle.net/1721.1/155982

Thesis

Contact Free Monitoring of Cell Density in a Bioreactor with Magnetic Resonance Relaxometry

Gaensbauer, Hans · 2025

Full title: Contact Free Monitoring of Cell Density in a Bioreactor with Magnetic Resonance Relaxometry

Authors: Gaensbauer, Hans

DOI: https://hdl.handle.net/1721.1/158512

Thesis

Process Analytical Technology in biopharmaceutical manufacturing

Cosby, Samuel T. (Samuel Thomas) · 2013

Full title: Process Analytical Technology in biopharmaceutical manufacturing

Authors: Cosby, Samuel T. (Samuel Thomas)

DOI: http://hdl.handle.net/1721.1/80911

Thesis

Wavelength selection-based nonlinear calibration for transcutaneous blood glucose sensing using Raman spectroscopy

Dingari, Narahara Chari; Barman, Ishan; Kang, Jeon Woong et al. · 2011

Full title: Wavelength selection-based nonlinear calibration for transcutaneous blood glucose sensing using Raman spectroscopy

Authors: Dingari, Narahara Chari; Barman, Ishan; Kang, Jeon Woong; Kong, Chae-Ryon; Dasari, Ramachandra Rao; Feld, Michael S.

DOI: http://hdl.handle.net/1721.1/67302

Thesis

Smart Data Analytics for Manufacturing Processes

Mohr, Fabian · 2024

Full title: Smart Data Analytics for Manufacturing Processes

Authors: Mohr, Fabian

DOI: https://hdl.handle.net/1721.1/155866

Thesis

Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Maloney, Andrew John · 2025

Full title: Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Authors: Maloney, Andrew John

DOI: https://hdl.handle.net/1721.1/158315

Thesis

Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays

Rohskopf, Zhumei · 2023

Full title: Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays

Authors: Rohskopf, Zhumei

DOI: https://hdl.handle.net/1721.1/152457

Thesis

Automated Optimization and Control of Modular Chemical Systems

Nikolakopoulou, Anastasia · 2022

Full title: Automated Optimization and Control of Modular Chemical Systems

Authors: Nikolakopoulou, Anastasia

DOI: https://hdl.handle.net/1721.1/143234

Thesis

Effect of photobleaching on calibration model development in biological Raman spectroscopy

Barman, Ishan; Kong, Chae-Ryon; Singh, Gajendra P. et al. · 2011

Full title: Effect of photobleaching on calibration model development in biological Raman spectroscopy

Authors: Barman, Ishan; Kong, Chae-Ryon; Singh, Gajendra P.; Dasari, Ramachandra Rao

DOI: http://hdl.handle.net/1721.1/64970

Thesis

Chemical Sensing as a Utility using Swept-Source Raman Spectroscopy

Persits, Nili · 2024

Full title: Chemical Sensing as a Utility using Swept-Source Raman Spectroscopy

Authors: Persits, Nili

DOI: https://hdl.handle.net/1721.1/156629

Thesis

Towards Using Portable NMR for Process Monitoring of Aqueous Turbulent Systems

Cutler, Brandon John · 2024

Full title: Towards Using Portable NMR for Process Monitoring of Aqueous Turbulent Systems

Authors: Cutler, Brandon John

DOI: https://escholarship.org/uc/item/30p745r6

Thesis

Multiplexed microfluidics utilizing genome-scale dynamics for biosensing and fermentation monitoring

Stasiowski, Elizabeth · 2019

Full title: Multiplexed microfluidics utilizing genome-scale dynamics for biosensing and fermentation monitoring

Authors: Stasiowski, Elizabeth

DOI: https://escholarship.org/uc/item/4n38g65x

Thesis

Vibrational Spectroscopic Applications of Fourier Transform Infrared and Raman Spectroscopy in Biochemistry and Microbiology

Alrasheedi, Muneera · 2021

Full title: Vibrational Spectroscopic Applications of Fourier Transform Infrared and Raman Spectroscopy in Biochemistry and Microbiology

Authors: Alrasheedi, Muneera

DOI: https://etheses.whiterose.ac.uk/id/eprint/30163/1/Muneera%20final%20PhD%20thesis%202021%20.pdf

Thesis

The use of Raman spectroscopy for the live aseptic monitoring of stem cell differentiation

Mitchell, Adam James · 2014

Full title: The use of Raman spectroscopy for the live aseptic monitoring of stem cell differentiation

Authors: Mitchell, Adam James

DOI: https://etheses.whiterose.ac.uk/id/eprint/7616/1/ethesis%20final%20copy.pdf

Thesis

Correlation of fermentation redox potential and induction of recombinant E. coli expression system

Guo, Jingjie 1990- · 2018

Full title: Correlation of fermentation redox potential and induction of recombinant E. coli expression system

Authors: Guo, Jingjie 1990-

DOI: http://hdl.handle.net/10388/11536

Thesis

Gaussian Process Adaptive Soft Sensors and their Applications in Inferential Control Systems

Abusnina, Ali · 2014

Full title: Gaussian Process Adaptive Soft Sensors and their Applications in Inferential Control Systems

Authors: Abusnina, Ali

DOI: https://etheses.whiterose.ac.uk/id/eprint/8870/19/EngD%20Thesis.pdf

Thesis

On-line analysis of bacterial metabolism by modern spectroscopic laser techniques

Metcalfe, George Derek · 2022

Full title: On-line analysis of bacterial metabolism by modern spectroscopic laser techniques

Authors: Metcalfe, George Derek

DOI: https://etheses.whiterose.ac.uk/id/eprint/31732/1/George%20Derek%20Metcalfe%20PhD%20Thesis%20Minor%20Corrections.pdf

Thesis

Microbial fuel cell-based biosensor for redox potential detection in fermentation process

Shen, Siyang · 2022

Full title: Microbial fuel cell-based biosensor for redox potential detection in fermentation process

Authors: Shen, Siyang

DOI: https://hdl.handle.net/10388/13798

Thesis

Kinetic modelling of dissolution and crystallization of slurries with attenuated total reflectance UV-visible absorbance and near-infrared reflectance measurements

Hsieh, Chun; Billeter, Julien; McNally, Mary Ellen et al. · 2012

Full title: Kinetic modelling of dissolution and crystallization of slurries with attenuated total reflectance UV-visible absorbance and near-infrared reflectance measurements

Authors: Hsieh, Chun; Billeter, Julien; McNally, Mary Ellen; Hoffman, Ronald; Gemperline, Paul

DOI: https://infoscience.epfl.ch/handle/20.500.14299/85670

Thesis

Kinetic modeling of dissolution of salicylic acid with in situ ATR UV-vis spectroscopy

Hsieh, Chun; Billeter, Julien; McNally, Mary Ellen et al. · 2011

Full title: Kinetic modeling of dissolution of salicylic acid with in situ ATR UV-vis spectroscopy

Authors: Hsieh, Chun; Billeter, Julien; McNally, Mary Ellen; Hoffman, Ronald; Gemperline, Paul

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76055

Thesis

Kinetic modeling of dissolution and crystallization of batch reactions with in situ spectroscopic measurements

Hsieh, Chun; Billeter, Julien; McNally, Mary Ellen et al. · 2012

Full title: Kinetic modeling of dissolution and crystallization of batch reactions with in situ spectroscopic measurements

Authors: Hsieh, Chun; Billeter, Julien; McNally, Mary Ellen; Hoffman, Ronald; Gemperline, Paul

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76230

Thesis

Real-time kinetic hard-modelling for the optimisation of reaction conditions and the detection of process upset in semi-batch reactors

Billeter, Julien; Neuhold, Yorck-Michael; Puxty, Graeme et al. · 2012

Full title: Real-time kinetic hard-modelling for the optimisation of reaction conditions and the detection of process upset in semi-batch reactors

Authors: Billeter, Julien; Neuhold, Yorck-Michael; Puxty, Graeme; Hungerbühler, Konrad

DOI: https://infoscience.epfl.ch/handle/20.500.14299/79407

Thesis

In-Situ Bioreactor Monitoring and Control Based on Mid-Infrared Spectroscopic Measurements

Rhiel, M.; Valentinotti, S.; Amrhein, M. et al. · 2004

Full title: In-Situ Bioreactor Monitoring and Control Based on Mid-Infrared Spectroscopic Measurements

Authors: Rhiel, M.; Valentinotti, S.; Amrhein, M.; Cannizzaro, C.; Herwig, C.; Voisard, D.; Stark, D.; Bonvin, D.; Marison, I.; von Stockar, U.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/175459

Thesis

Subspace Correction Methods in Multivariate Calibration

Gujral, Pamandeep Singh · 2010

Full title: Subspace Correction Methods in Multivariate Calibration

Authors: Gujral, Pamandeep Singh

DOI: https://infoscience.epfl.ch/handle/20.500.14299/56274

Thesis

Simplified approaches to mid-infrared spectrometers calibration for bioprocess monitoring applications

Schenk, Jonas · 2007

Full title: Simplified approaches to mid-infrared spectrometers calibration for bioprocess monitoring applications

Authors: Schenk, Jonas

DOI: https://infoscience.epfl.ch/handle/20.500.14299/10286

Thesis

Online optimisation and detection of process upset in semi-batch reactors using a kinetic modelling approach

Billeter, Julien; Neuhold, Yorck-Michael; Puxty, Graeme et al. · 2012

Full title: Online optimisation and detection of process upset in semi-batch reactors using a kinetic modelling approach

Authors: Billeter, Julien; Neuhold, Yorck-Michael; Puxty, Graeme; Hungerbühler, Konrad

DOI: https://infoscience.epfl.ch/handle/20.500.14299/79409

Thesis

Cole-Cole, linear and multivariate modeling of capacitance data for on-line monitoring of biomass

Dabros, Michal; Dennewald, Danielle; Currie, David J. et al. · 2010

Full title: Cole-Cole, linear and multivariate modeling of capacitance data for on-line monitoring of biomass

Authors: Dabros, Michal; Dennewald, Danielle; Currie, David J.; Lee, Mark H.; Todd, Robert W.; Marison, Ian W.; von Stockar, U.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/58355

Thesis

Electrochemical Biosensors for On-line Monitoring of Cell Culture Metabolism

Boero, Cristina · 2012

Full title: Electrochemical Biosensors for On-line Monitoring of Cell Culture Metabolism

Authors: Boero, Cristina

DOI: https://infoscience.epfl.ch/handle/20.500.14299/87270

Thesis

Evaluation of an online biomass probe to monitor cell growth and cell death.

Perani, A; Gloria, B; Wang, D et al. · 2022

Full title: Evaluation of an online biomass probe to monitor cell growth and cell death.

Authors: Perani, A; Gloria, B; Wang, D; Buffier, A-S; Berteau, O; Esteban, G; Smyth, FE; Scott, AM

DOI: https://hdl.handle.net/11343/303929

Thesis

DESIGN OF A SELF-CONSTRUCTED ELECTROCHEMICAL SYSTEM FOR HIGH SENSITIVITY DETECTION OF 9 MAJOR WATER-SOLUBLE VITAMINS AND DEGRADATION PRODUCTS IN MAMMALIAN CELL CULTURE MEDIA

Chen, Haiqi · 2024

Full title: DESIGN OF A SELF-CONSTRUCTED ELECTROCHEMICAL SYSTEM FOR HIGH SENSITIVITY DETECTION OF 9 MAJOR WATER-SOLUBLE VITAMINS AND DEGRADATION PRODUCTS IN MAMMALIAN CELL CULTURE MEDIA

Authors: Chen, Haiqi

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/69624

Thesis

A Digital Approach to Model Quality and Sensory Traits of Beers Fermented under Sonication Based on Chemical Fingerprinting

Viejo, CG; Fuentes, S · 2021

Full title: A Digital Approach to Model Quality and Sensory Traits of Beers Fermented under Sonication Based on Chemical Fingerprinting

Authors: Viejo, CG; Fuentes, S

DOI: https://hdl.handle.net/11343/274597

Thesis

Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture

Shariatzadeh, M; Lopes, AG; Glen, KE et al. · 2021

Full title: Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture

Authors: Shariatzadeh, M; Lopes, AG; Glen, KE; Sinclair, A; Thomas, RJ

DOI: https://hdl.handle.net/11343/289743

Thesis

Predictive models for upstream mammalian cell culture development: a review

Yatipanthalawa, BS; Gras, SL · 2023

Full title: Predictive models for upstream mammalian cell culture development: a review

Authors: Yatipanthalawa, BS; Gras, SL

DOI: https://hdl.handle.net/11343/339523

Thesis

Capturing prediction uncertainty in upstream cell culture models using conformal prediction and Gaussian processes

Pham, TD; Aickelin, U; Bassett, R · 2024

Full title: Capturing prediction uncertainty in upstream cell culture models using conformal prediction and Gaussian processes

Authors: Pham, TD; Aickelin, U; Bassett, R

DOI: https://hdl.handle.net/11343/339627

Thesis

Bioreactor Controls for High Oxygen Uptake Rate (OUR) Demand Processes

Cho, Hyun Woo · 2019

Full title: Bioreactor Controls for High Oxygen Uptake Rate (OUR) Demand Processes

Authors: Cho, Hyun Woo

DOI: http://jhir.library.jhu.edu/handle/1774.2/60474

Thesis

Data-driven soft sensing towards quality monitoring of industrial pasteurization processes

Filios, Gabriel; Kyriakopoulos, Andreas; Livanios, Stavros et al. · 2022

Full title: Data-driven soft sensing towards quality monitoring of industrial pasteurization processes

Authors: Filios, Gabriel; Kyriakopoulos, Andreas; Livanios, Stavros; Manolopoulos, Fotis; Nikoletseas, Sotiris; Panagiotou, Stefanos H; Spirakis, Paul

DOI: https://livrepository.liverpool.ac.uk/3156617/1/DCOSS22.pdf

Thesis

A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments

Karimi Alavijeh, M; Lee, YY; Gras, SL · 2024

Full title: A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments

Authors: Karimi Alavijeh, M; Lee, YY; Gras, SL

DOI: https://hdl.handle.net/11343/351093

Thesis

Application of dielectric spectroscopy in an industrial bioprocess utilizing the baculovirus expression vector system

Brix, Alexander · 2016

Full title: Application of dielectric spectroscopy in an industrial bioprocess utilizing the baculovirus expression vector system

Authors: Brix, Alexander

DOI: http://hdl.handle.net/2097/32926

Thesis

Enhancing beer authentication, quality, and control assessment using non-invasive spectroscopy through bottle and machine learning modeling

Harris, N; Gonzalez Viejo, C; Zhang, J et al. · 2025

Full title: Enhancing beer authentication, quality, and control assessment using non-invasive spectroscopy through bottle and machine learning modeling

Authors: Harris, N; Gonzalez Viejo, C; Zhang, J; Pang, A; Hernandez-Brenes, C; Fuentes, S

DOI: https://hdl.handle.net/11343/359649

Thesis

Method development of flow cytometry analysis of yeast and lactic acid bacteria viability for alcohol fermentation

Komahan, Megha · 2023

Full title: Method development of flow cytometry analysis of yeast and lactic acid bacteria viability for alcohol fermentation

Authors: Komahan, Megha

DOI: http://lup.lub.lu.se/student-papers/record/9125957

Thesis

Probing Control in B. licheniformis Fermentations

Johnsson, Ola · 2010

Full title: Probing Control in B. licheniformis Fermentations

Authors: Johnsson, Ola

DOI: http://lup.lub.lu.se/student-papers/record/8847429

Thesis

Using an Industrial Robot Arm for Monitoring Cultivations of Mammalian Cells in Pilot Scale

Poggendorf, Iris; Lütkemeyer, Dirk; Scherer, Torsten et al. · 2001

Full title: Using an Industrial Robot Arm for Monitoring Cultivations of Mammalian Cells in Pilot Scale

Authors: Poggendorf, Iris;Lütkemeyer, Dirk;Scherer, Torsten;Zhang, Jianwei;Knoll, Alois;Lehmann, Jürgen

DOI: https://mediatum.ub.tum.de/1290595

Thesis

Perturbation-based Control of Industrial Fed-batch Bioprocesses

Johnsson, Ola · 2015

Full title: Perturbation-based Control of Industrial Fed-batch Bioprocesses

Authors: Johnsson, Ola

DOI: https://lup.lub.lu.se/record/8412104

Thesis

Real time estimations of kLa and viscosity in a fermentation pilot plant

Norberg, Arvid · 2022

Full title: Real time estimations of kLa and viscosity in a fermentation pilot plant

Authors: Norberg, Arvid

DOI: http://lup.lub.lu.se/student-papers/record/9096296

Thesis

APPLICATIONS OF METABOLOMICS APPROACHES FOR THE IMPROVEMENT OF MICROBIAL BIOPROCESS

Tengsuttiwat, Thanyaporn · 2025

Full title: APPLICATIONS OF METABOLOMICS APPROACHES FOR THE IMPROVEMENT OF MICROBIAL BIOPROCESS

Authors: Tengsuttiwat, Thanyaporn

DOI: https://livrepository.liverpool.ac.uk/3192146/1/201453891_Sep2024.pdf

Thesis

FIA-Based Process Monitoring in Simulated Bioreactor for Monoclonal Antibody Production

Fernandez Alcantara, Leonardo Renzo · 2025

Full title: FIA-Based Process Monitoring in Simulated Bioreactor for Monoclonal Antibody Production

Authors: Fernandez Alcantara, Leonardo Renzo

DOI: http://lup.lub.lu.se/student-papers/record/9188201

Thesis

Biosensors and Automation for Bioprocess Monitoring and Control

Kumar, M A · 2011

Full title: Biosensors and Automation for Bioprocess Monitoring and Control

Authors: Kumar, M A

DOI: https://lup.lub.lu.se/record/1737382

Thesis

Ultrasound based PAT-concept for online monitoring of fermentative bioprocesses.

Hoche, Sven · 2018

Full title: Ultrasound based PAT-concept for online monitoring of fermentative bioprocesses.

Authors: Hoche, Sven

DOI: https://mediatum.ub.tum.de/1327420

Thesis

Biomass soft sensor for a Pichia pastoris fed‐batch process based on phase detection and hybrid modeling

Brunner, Vincent; Siegl, Manuel; Geier, Dominik et al. · 2020

Full title: Biomass soft sensor for a Pichia pastoris fed‐batch process based on phase detection and hybrid modeling

Authors: Brunner, Vincent;Siegl, Manuel;Geier, Dominik;Becker, Thomas

DOI: https://mediatum.ub.tum.de/1576014

Thesis

Computationally aided reliability analysis of sensor data using multivariate data analysis and modelling approaches for bioprocesses

Krause, Daniel · 2018

Full title: Computationally aided reliability analysis of sensor data using multivariate data analysis and modelling approaches for bioprocesses

Authors: Krause, Daniel

DOI: https://mediatum.ub.tum.de/1364668

Thesis

Mathematially based management of Saccharomyces sp. batch propagations and fermentations

Kurz, Tomas · 2005

Full title: Mathematially based management of Saccharomyces sp. batch propagations and fermentations

Authors: Kurz, Tomas

DOI: https://mediatum.ub.tum.de/603297

Thesis

Metabolic Profiling of Mesenchymal Stromal Cells for Critical Quality Attribute Identification

Maughon, Ty · 2024

Full title: Metabolic Profiling of Mesenchymal Stromal Cells for Critical Quality Attribute Identification

Authors: Maughon, Ty

DOI: https://openscholar.uga.edu/record/3044/files/MaughonTimothyPHD.pdf

Thesis

Phenotypic and Metabolic Profiling of Biological Samples in Near Real-Time Using Raman Spectroscopy

Zu, Theresah Nom Korbieh · 2016

Full title: Phenotypic and Metabolic Profiling of Biological Samples in Near Real-Time Using Raman Spectroscopy

Authors: Zu, Theresah Nom Korbieh

DOI: http://hdl.handle.net/10919/65153

Thesis

Machine Learning and Multivariate Statistics for Optimizing Bioprocessing and Polyolefin Manufacturing

Agarwal, Aman · 2022

Full title: Machine Learning and Multivariate Statistics for Optimizing Bioprocessing and Polyolefin Manufacturing

Authors: Agarwal, Aman

DOI: http://hdl.handle.net/10919/107480

Thesis

Data Analytics and Machine Learning Applications in Fermentation Processes and Molecular Property Prediction

Nguyen, Xuan Dung · 2025

Full title: Data Analytics and Machine Learning Applications in Fermentation Processes and Molecular Property Prediction

Authors: Nguyen, Xuan Dung

DOI: https://hdl.handle.net/10919/134219

Thesis

Compressive Sensing Approaches for Sensor based Predictive Analytics in Manufacturing and Service Systems

Bastani, Kaveh · 2016

Full title: Compressive Sensing Approaches for Sensor based Predictive Analytics in Manufacturing and Service Systems

Authors: Bastani, Kaveh

DOI: http://hdl.handle.net/10919/64917

Thesis

Miniaturisation of pH Holographic Sensors for Nano-Bioreactors

Chan, Leon, Cong Zhi · 2017

Full title: Miniaturisation of pH Holographic Sensors for Nano-Bioreactors

Authors: Chan, Leon, Cong Zhi

DOI: https://www.repository.cam.ac.uk/handle/1810/268167

Thesis

Neural Networks in Bioprocessing and Chemical Engineering

Baughman, D. Richard · 2014

Full title: Neural Networks in Bioprocessing and Chemical Engineering

Authors: Baughman, D. Richard

DOI: http://hdl.handle.net/10919/29061

Thesis

Design and Fabrication of Piezoelectric Sensors and Actuators for Characterization of Soft Materials

Cesewski, Ellen · 2022

Full title: Design and Fabrication of Piezoelectric Sensors and Actuators for Characterization of Soft Materials

Authors: Cesewski, Ellen

DOI: http://hdl.handle.net/10919/108758

Thesis

Mid-Infrared Integrated Devices for Optical Chemical Sensing

Alimagham, Farah Christina · 2020

Full title: Mid-Infrared Integrated Devices for Optical Chemical Sensing

Authors: Alimagham, Farah Christina

DOI: https://www.repository.cam.ac.uk/handle/1810/307700

Thesis

Virtualization and real-time analysis of pharmaceutical and food products by near infrared spectroscopy

Sun, Dong · 2018

Full title: Virtualization and real-time analysis of pharmaceutical and food products by near infrared spectroscopy

Authors: Sun, Dong

DOI: http://hdl.handle.net/10803/459155

Thesis

Development of analytical methods based on Near Infrared Spectroscopy for monitoring of pharmaceutical and biotechnological processes and control of new psychoactive substances

Miró Vera, Aira Yira · 2020

Full title: Development of analytical methods based on Near Infrared Spectroscopy for monitoring of pharmaceutical and biotechnological processes and control of new psychoactive substances

Authors: Miró Vera, Aira Yira

DOI: http://hdl.handle.net/10803/669569

Thesis

Development of new analytical methods using Near Infrared and Chemometrics for pharmaceutical quality control: Enhancement of modelling strategies towards a better product understanding

Cárdenas Espitia, Vanessa · 2016

Full title: Development of new analytical methods using Near Infrared and Chemometrics for pharmaceutical quality control: Enhancement of modelling strategies towards a better product understanding

Authors: Cárdenas Espitia, Vanessa

DOI: http://hdl.handle.net/10803/377466

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