Intensified And Model Based Doe Versus Traditional

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Paper Design and optimization of an IgG human ELISA assay reactive to recombinant RBD SARS-CoV-2 protein.

Rodríguez, María Celeste; Ceaglio, Natalia; Gugliotta, Agustina et al. · 2022 · Applied microbiology and biotechnology · DOI

Full title: Design and optimization of an IgG human ELISA assay reactive to recombinant RBD SARS-CoV-2 protein.

Authors: Rodríguez, María Celeste; Ceaglio, Natalia; Gugliotta, Agustina; Villarraza, Javier; Garay, Ernesto; Fuselli, Antonela; Gastaldi, Victoria; Tardivo, María Belén; Antuña, Sebastián; Fontana, Diego; Prieto, Claudio

Year: 2022

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-022-12254-w

Paper Optimized biosynthesis of bioactive silver nanoparticle-kombucha cellulose nanocomposites for enhanced antimicrobial applications.

Aboul-Nasr, M Bassam; Yasien, Alaa A; Mohamed, Sabah S et al. · 2025 · Applied microbiology and biotechnology · DOI

Full title: Optimized biosynthesis of bioactive silver nanoparticle-kombucha cellulose nanocomposites for enhanced antimicrobial applications.

Authors: Aboul-Nasr, M Bassam; Yasien, Alaa A; Mohamed, Sabah S; Obiedallah, Marwa

Year: 2025

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-025-13585-0

Paper Endophytic Aspergillus fumigatiaffinis: Novel paclitaxel production and optimization insights.

Obiedallah, Marwa; Yasien, Alaa A; Mohamed, Sabah S et al. · 2024 · Applied microbiology and biotechnology · DOI

Full title: Endophytic Aspergillus fumigatiaffinis: Novel paclitaxel production and optimization insights.

Authors: Obiedallah, Marwa; Yasien, Alaa A; Mohamed, Sabah S; Aboul-Nasr, M Bassam

Year: 2024

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-024-13230-2

Paper Recombinant T7 RNA polymerase production using ClearColi BL21(DE3) and animal-free media for in vitro transcription.

Liang, Qianying; Tu, Bowen; Cui, Lun · 2024 · Applied microbiology and biotechnology · DOI

Full title: Recombinant T7 RNA polymerase production using ClearColi BL21(DE3) and animal-free media for in vitro transcription.

Authors: Liang, Qianying; Tu, Bowen; Cui, Lun

Year: 2024

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-023-12939-w

Paper Optimisation of the fermentation media to enhance the production of the bioactive isomer of vitamin menaquinone-7.

Lal, Neha; Seifan, Mostafa; Berenjian, Aydin · 2022 · Bioprocess and biosystems engineering · DOI

Full title: Optimisation of the fermentation media to enhance the production of the bioactive isomer of vitamin menaquinone-7.

Authors: Lal, Neha; Seifan, Mostafa; Berenjian, Aydin

Year: 2022

Venue: Bioprocess and biosystems engineering

DOI: https://doi.org/10.1007/s00449-022-02752-6

Paper Design modification and optimisation of the perfusion system of a tri-axial bioreactor for tissue engineering.

Hussein, Husnah; Williams, David J; Liu, Yang · 2015 · Bioprocess and biosystems engineering · DOI

Full title: Design modification and optimisation of the perfusion system of a tri-axial bioreactor for tissue engineering.

Authors: Hussein, Husnah; Williams, David J; Liu, Yang

Year: 2015

Venue: Bioprocess and biosystems engineering

DOI: https://doi.org/10.1007/s00449-015-1371-1

Paper Model-assisted DoE software: optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses.

Moser, André; Kuchemüller, Kim B; Deppe, Sahar et al. · 2021 · Bioprocess and biosystems engineering · DOI

Full title: Model-assisted DoE software: optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses.

Authors: Moser, André; Kuchemüller, Kim B; Deppe, Sahar; Hernández Rodríguez, Tanja; Frahm, Björn; Pörtner, Ralf; Hass, Volker C; Möller, Johannes

Year: 2021

Venue: Bioprocess and biosystems engineering

DOI: https://doi.org/10.1007/s00449-020-02478-3

Paper Design of experiments and machine learning with application to industrial experiments

Fontana, Roberto; Molena, Alberto; Pegoraro, Luca et al. · 2023 · Statistical Papers · DOI

Full title: Design of experiments and machine learning with application to industrial experiments

Authors: Fontana, Roberto; Molena, Alberto; Pegoraro, Luca; Salmaso, Luigi

Year: 2023

Venue: Statistical Papers

DOI: https://doi.org/10.1007/s00362-023-01437-w

Paper Tuning Dunaliella tertiolecta for Enhanced Antioxidant Production by Modification of Culture Conditions.

Roy, Uttam K; Nielsen, Birthe V; Milledge, John J · 2021 · Marine biotechnology (New York, N.Y.) · DOI

Full title: Tuning Dunaliella tertiolecta for Enhanced Antioxidant Production by Modification of Culture Conditions.

Authors: Roy, Uttam K; Nielsen, Birthe V; Milledge, John J

Year: 2021

Venue: Marine biotechnology (New York, N.Y.)

DOI: https://doi.org/10.1007/s10126-021-10041-8

Paper Efficient design of experiments for sensitivity analysis based on polynomial chaos expansions

Evgeny Burnaev; I. Panin; B. Sudret · 2017 · Annals of Mathematics and Artificial Intelligence · DOI

Full title: Efficient design of experiments for sensitivity analysis based on polynomial chaos expansions

Authors: Evgeny Burnaev; I. Panin; B. Sudret

Year: 2017

Venue: Annals of Mathematics and Artificial Intelligence

DOI: https://doi.org/10.1007/s10472-017-9542-1

Paper Design of experiment (DOE) applied to artificial neural network architecture enables rapid bioprocess improvement.

Rodriguez-Granrose, Daniel; Jones, Amanda; Loftus, Hannah et al. · 2021 · Bioprocess and biosystems engineering · DOI

Full title: Design of experiment (DOE) applied to artificial neural network architecture enables rapid bioprocess improvement.

Authors: Rodriguez-Granrose, Daniel; Jones, Amanda; Loftus, Hannah; Tandeski, Terry; Heaton, Will; Foley, Kevin T; Silverman, Lara

Year: 2021

Venue: Bioprocess and biosystems engineering

DOI: https://doi.org/10.1007/s00449-021-02529-3

Paper Research on the ability of propionic acid and vitamin B12 biosynthesis by Propionibacterium freudenreichii strain T82.

Piwowarek, Kamil; Lipińska, Edyta; Hać-Szymańczuk, Elżbieta et al. · 2018 · Antonie van Leeuwenhoek · DOI

Full title: Research on the ability of propionic acid and vitamin B12 biosynthesis by Propionibacterium freudenreichii strain T82.

Authors: Piwowarek, Kamil; Lipińska, Edyta; Hać-Szymańczuk, Elżbieta; Bzducha-Wróbel, Anna; Synowiec, Alicja

Year: 2018

Venue: Antonie van Leeuwenhoek

DOI: https://doi.org/10.1007/s10482-017-0991-7

Paper Design of experiments approach to engineer cell-secreted matrices for directing osteogenic differentiation.

Decaris, Martin L; Leach, J Kent · 2011 · Annals of biomedical engineering · DOI

Full title: Design of experiments approach to engineer cell-secreted matrices for directing osteogenic differentiation.

Authors: Decaris, Martin L; Leach, J Kent

Year: 2011

Venue: Annals of biomedical engineering

DOI: https://doi.org/10.1007/s10439-010-0217-x

Paper Tuning the Microenvironment to Create Functionally Distinct Mesenchymal Stromal Cell Spheroids.

Thai, Victoria L; Candelas, Diego O; Leach, J Kent · 2023 · Annals of biomedical engineering · DOI

Full title: Tuning the Microenvironment to Create Functionally Distinct Mesenchymal Stromal Cell Spheroids.

Authors: Thai, Victoria L; Candelas, Diego O; Leach, J Kent

Year: 2023

Venue: Annals of biomedical engineering

DOI: https://doi.org/10.1007/s10439-023-03162-9

Paper Influences of operational parameters on phosphorus removal in batch and continuous electrocoagulation process performance

D. Nguyen; Y. Yoon; X. Bui et al. · 2017 · Environmental science and pollution research international · DOI

Full title: Influences of operational parameters on phosphorus removal in batch and continuous electrocoagulation process performance

Authors: D. Nguyen; Y. Yoon; X. Bui; Sung Su Kim; S. Chang; Wenshan Guo; H. Ngo

Year: 2017

Venue: Environmental science and pollution research international

DOI: https://doi.org/10.1007/s11356-017-0180-2

Paper Statistical investigation of extraction parameters of keratin from chicken feather using Design-Expert.

Kamarudin, Nuruldiyanah Binti; Sharma, Swati; Gupta, Arun et al. · 2017 · 3 Biotech · DOI

Full title: Statistical investigation of extraction parameters of keratin from chicken feather using Design-Expert.

Authors: Kamarudin, Nuruldiyanah Binti; Sharma, Swati; Gupta, Arun; Kee, Chua Gek; Chik, Syed Mohd Saufi Bin Tuan; Gupta, Ritu

Year: 2017

Venue: 3 Biotech

DOI: https://doi.org/10.1007/s13205-017-0767-9

Paper Enhanced production of thermostable amidase from Geobacillus subterraneus RL-2a MTCC 11502 via optimization of physicochemical parameters using Taguchi DOE methodology.

Mehta, Praveen Kumar; Bhatia, Shashi Kant; Bhatia, Ravi Kant et al. · 2016 · 3 Biotech · DOI

Full title: Enhanced production of thermostable amidase from Geobacillus subterraneus RL-2a MTCC 11502 via optimization of physicochemical parameters using Taguchi DOE methodology.

Authors: Mehta, Praveen Kumar; Bhatia, Shashi Kant; Bhatia, Ravi Kant; Bhalla, Tek Chand

Year: 2016

Venue: 3 Biotech

DOI: https://doi.org/10.1007/s13205-016-0390-1

Paper Oxidative Depolymerization of Lignosulfonates for Muconic Acid Production Using Recombinant Pseudomonas putida CJ475

Selda Bekirovska; F. Lund; L. I. Ajakaiye Jensen et al. · 2025 · Waste and Biomass Valorization · DOI

Full title: Oxidative Depolymerization of Lignosulfonates for Muconic Acid Production Using Recombinant Pseudomonas putida CJ475

Authors: Selda Bekirovska; F. Lund; L. I. Ajakaiye Jensen; Christian P. Hulteberg; M. Gorwa-Grauslund; Omar Y. Abdelaziz

Year: 2025

Venue: Waste and Biomass Valorization

DOI: https://doi.org/10.1007/s12649-025-02890-4

Paper Development of semi-defined rice straw-based medium for butanol production and its kinetic study.

Ranjan, Amrita; Mayank, Rahul; Moholkar, Vijayanand S · 2013 · 3 Biotech · DOI

Full title: Development of semi-defined rice straw-based medium for butanol production and its kinetic study.

Authors: Ranjan, Amrita; Mayank, Rahul; Moholkar, Vijayanand S

Year: 2013

Venue: 3 Biotech

DOI: https://doi.org/10.1007/s13205-013-0120-x

Paper Statistical optimization of chitosan-based synthesis strategies to generate albumin nanoparticles.

Martín-Escaño, Aitana; Barbuzano, Claudia; Rodríguez-Díaz, Juan Manuel et al. · 2026 · Drug delivery and translational research · DOI

Full title: Statistical optimization of chitosan-based synthesis strategies to generate albumin nanoparticles.

Authors: Martín-Escaño, Aitana; Barbuzano, Claudia; Rodríguez-Díaz, Juan Manuel; Pérez-Herrero, Edgar

Year: 2026

Venue: Drug delivery and translational research

DOI: https://doi.org/10.1007/s13346-026-02046-4

Paper Optimization of gelatinolytic enzyme production by B. amyloliquefaciens sp. H11 through Plackett–Burman design and response surface methodology

S. Sai-ut; S. Benjakul; P. Sumpavapol et al. · 2014 · International Aquatic Research · DOI

Full title: Optimization of gelatinolytic enzyme production by B. amyloliquefaciens sp. H11 through Plackett–Burman design and response surface methodology

Authors: S. Sai-ut; S. Benjakul; P. Sumpavapol; H. Kishimura

Year: 2014

Venue: International Aquatic Research

DOI: https://doi.org/10.1007/s40071-014-0059-5

Paper Application of Sono–photo-Fenton process for degradation of phenol derivatives in petrochemical wastewater using full factorial design of experiment

Shokri, Aref · 2018 · International Journal of Industrial Chemistry · DOI

Full title: Application of Sono–photo-Fenton process for degradation of phenol derivatives in petrochemical wastewater using full factorial design of experiment

Authors: Shokri, Aref

Year: 2018

Venue: International Journal of Industrial Chemistry

DOI: https://doi.org/10.1007/s40090-018-0159-y

Paper 3D printed ceramics as solid supports for enzyme immobilization: an automated DoE approach for applications in continuous flow.

Valotta, Alessia; Maier, Manuel C; Soritz, Sebastian et al. · 2021 · Journal of flow chemistry · DOI

Full title: 3D printed ceramics as solid supports for enzyme immobilization: an automated DoE approach for applications in continuous flow.

Authors: Valotta, Alessia; Maier, Manuel C; Soritz, Sebastian; Pauritsch, Magdalena; Koenig, Michael; Brouczek, Dominik; Schwentenwein, Martin; Gruber-Woelfler, Heidrun

Year: 2021

Venue: Journal of flow chemistry

DOI: https://doi.org/10.1007/s41981-021-00163-4

Paper HPLC-PDA analysis of ACE-inhibitors, hydrochlorothiazide and indapamide utilizing design of experiments

Dawud, Eyad Rashed; Shakya, Ashok K. · 2014 · Arabian Journal of Chemistry · DOI

Full title: HPLC-PDA analysis of ACE-inhibitors, hydrochlorothiazide and indapamide utilizing design of experiments

Authors: Dawud, Eyad Rashed; Shakya, Ashok K.

Year: 2014

Venue: Arabian Journal of Chemistry

DOI: https://doi.org/10.1016/j.arabjc.2014.10.052

Paper Development and validation of simple RP-HPLC-PDA analytical protocol for zileuton assisted with Design of Experiments for robustness determination

Ganorkar, Saurabh B.; Dhumal, Dinesh; Shirkhedkar, Atul A. · 2014 · Arabian Journal of Chemistry · DOI

Full title: Development and validation of simple RP-HPLC-PDA analytical protocol for zileuton assisted with Design of Experiments for robustness determination

Authors: Ganorkar, Saurabh B.; Dhumal, Dinesh; Shirkhedkar, Atul A.

Year: 2014

Venue: Arabian Journal of Chemistry

DOI: https://doi.org/10.1016/j.arabjc.2014.03.009

Paper Blocking response surface designs

Peter Goos; A. Donev · 2006 · Computational Statistics & Data Analysis · DOI

Full title: Blocking response surface designs

Authors: Peter Goos; A. Donev

Year: 2006

Venue: Computational Statistics & Data Analysis

DOI: https://doi.org/10.1016/j.csda.2005.11.003

Paper Modeling and optimization of factors influencing adsorptive performance of agrowaste-derived nanocellulose/iron oxide nanobiocomposites during remediation of arsenic contaminated groundwater.

Julie Baruah; C. Chaliha; E. Kalita et al. · 2020 · International Journal of Biological Macromolecules · DOI

Full title: Modeling and optimization of factors influencing adsorptive performance of agrowaste-derived nanocellulose/iron oxide nanobiocomposites during remediation of arsenic contaminated groundwater.

Authors: Julie Baruah; C. Chaliha; E. Kalita; B. Nath; R. A. Field; Pritam Deb

Year: 2020

Venue: International Journal of Biological Macromolecules

DOI: https://doi.org/10.1016/j.ijbiomac.2020.07.113

Paper Co-treatment of landfill leachate and municipal wastewater using the ZELIAC/zeolite constructed wetland system.

A. Mojiri; Ziyang Lou; R. Tajuddin et al. · 2016 · Journal of Environmental Management · DOI

Full title: Co-treatment of landfill leachate and municipal wastewater using the ZELIAC/zeolite constructed wetland system.

Authors: A. Mojiri; Ziyang Lou; R. Tajuddin; Hossein Farraji; N. Alifar

Year: 2016

Venue: Journal of Environmental Management

DOI: https://doi.org/10.1016/j.jenvman.2015.10.020

Paper Mixture design as a tool for improving full-to-empty particle ratios across various GOIs in rAAV production.

Tzimou, Konstantina; Hulsbus-Andreu, Pol; Yildirim, Ece Bahar et al. · 2026 · Gene therapy · DOI

Full title: Mixture design as a tool for improving full-to-empty particle ratios across various GOIs in rAAV production.

Authors: Tzimou, Konstantina; Hulsbus-Andreu, Pol; Yildirim, Ece Bahar; Nielsen, Lars K; Lavado-García, Jesús

Year: 2026

Venue: Gene therapy

DOI: https://doi.org/10.1038/s41434-025-00546-5

Paper Optimization of Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Mass Spectrometry Detection of Glutamine-FMOC Ad-Hoc Derivative by Central Composite Design.

Bheemanapally, Khaggeswar; Ibrahim, Mostafa M H; Briski, Karen P · 2020 · Scientific reports · DOI

Full title: Optimization of Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Mass Spectrometry Detection of Glutamine-FMOC Ad-Hoc Derivative by Central Composite Design.

Authors: Bheemanapally, Khaggeswar; Ibrahim, Mostafa M H; Briski, Karen P

Year: 2020

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-020-64099-w

Paper Preclinical optimization of an enterotoxigenic Escherichia coli adjuvanted subunit vaccine using response surface design of experiments.

Poncet, David; Hessler, Catherine; Liang, Hong et al. · 2020 · NPJ vaccines · DOI

Full title: Preclinical optimization of an enterotoxigenic Escherichia coli adjuvanted subunit vaccine using response surface design of experiments.

Authors: Poncet, David; Hessler, Catherine; Liang, Hong; Gautheron, Sylviane; Sergent, Michelle; Rintala, Nicholas D; Seydoux, Emilie; Huang, Po-Wei D; Argilla, David; Ruiz, Sophie; Heinrichs, Jon; Maciel, Milton; Orr, Mark T

Year: 2020

Venue: NPJ vaccines

DOI: https://doi.org/10.1038/s41541-020-00228-w

Paper Parameters influencing the size of chitosan-TPP nano- and microparticles.

Sreekumar, Sruthi; Goycoolea, Francisco M; Moerschbacher, Bruno M et al. · 2018 · Scientific reports · DOI

Full title: Parameters influencing the size of chitosan-TPP nano- and microparticles.

Authors: Sreekumar, Sruthi; Goycoolea, Francisco M; Moerschbacher, Bruno M; Rivera-Rodriguez, Gustavo R

Year: 2018

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-018-23064-4

Paper Utilisation of Design of Experiments Approach to Optimise Supercritical Fluid Extraction of Medicinal Cannabis

Rochfort, Simone; Isbel, Ashley; Ezernieks, Vilnis et al. · 2020 · Scientific Reports · DOI

Full title: Utilisation of Design of Experiments Approach to Optimise Supercritical Fluid Extraction of Medicinal Cannabis

Authors: Rochfort, Simone; Isbel, Ashley; Ezernieks, Vilnis; Elkins, Aaron; Vincent, Delphine; Deseo, Myrna A.; Spangenberg, Germán

Year: 2020

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-020-66119-1

Paper Optimization of an O2-balanced bioartificial pancreas for type 1 diabetes using statistical design of experiment.

Mouré, Anne; Bekir, Sawsen; Bacou, Elodie et al. · 2022 · Scientific reports · DOI

Full title: Optimization of an O2-balanced bioartificial pancreas for type 1 diabetes using statistical design of experiment.

Authors: Mouré, Anne; Bekir, Sawsen; Bacou, Elodie; Pruvost, Quentin; Haurogné, Karine; Allard, Marie; De Beaurepaire, Laurence; Bosch, Steffi; Riochet, David; Gauthier, Olivier; Blancho, Gilles; Soulillou, Jean-Paul; Poncelet, Denis; Mignot, Grégoire; Courcoux, Philippe; Jegou, Dominique; Bach, Jean-Marie; Mosser, Mathilde

Year: 2022

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-022-07887-w

Paper Development of a zinc-enriched yeast strain for nutritional applications using low-cost ingredients

Pegah Zare; Minoo Giyahchi; Tabasom Entezari et al. · 2025 · Scientific Reports · DOI

Full title: Development of a zinc-enriched yeast strain for nutritional applications using low-cost ingredients

Authors: Pegah Zare; Minoo Giyahchi; Tabasom Entezari; Hamid Moghimi

Year: 2025

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-025-26371-9

Paper A Design of Experiments (DoE) Approach Accelerates the Optimization of Copper-Mediated 18F-Fluorination Reactions of Arylstannanes.

Bowden, Gregory D; Pichler, Bernd J; Maurer, Andreas · 2019 · Scientific reports · DOI

Full title: A Design of Experiments (DoE) Approach Accelerates the Optimization of Copper-Mediated 18F-Fluorination Reactions of Arylstannanes.

Authors: Bowden, Gregory D; Pichler, Bernd J; Maurer, Andreas

Year: 2019

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-019-47846-6

Paper A pre-formulation study of tetracaine loaded in optimized nanostructured lipid carriers.

Castro, Simone R; Ribeiro, Lígia N M; Breitkreitz, Márcia C et al. · 2021 · Scientific reports · DOI

Full title: A pre-formulation study of tetracaine loaded in optimized nanostructured lipid carriers.

Authors: Castro, Simone R; Ribeiro, Lígia N M; Breitkreitz, Márcia C; Guilherme, Viviane A; Rodrigues da Silva, Gustavo H; Mitsutake, Hery; Alcântara, Ana C S; Yokaichiya, Fabiano; Franco, Margareth K K D; Clemens, Daniel; Kent, Ben; Lancellotti, Marcelo; de Araújo, Daniele R; de Paula, Eneida

Year: 2021

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-021-99743-6

Paper Quality by design approach identifies critical parameters driving oxygen delivery performance in vitro for perfluorocarbon based artificial oxygen carriers.

Lambert, Eric; Janjic, Jelena M · 2021 · Scientific reports · DOI

Full title: Quality by design approach identifies critical parameters driving oxygen delivery performance in vitro for perfluorocarbon based artificial oxygen carriers.

Authors: Lambert, Eric; Janjic, Jelena M

Year: 2021

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-021-84076-1

Paper Numerical parametric optimization of fluid flow profiles in membranes using the Taguchi method.

Arslan, Muhammad; Xian, Haizhen; Shah, Imran et al. · 2025 · Scientific reports · DOI

Full title: Numerical parametric optimization of fluid flow profiles in membranes using the Taguchi method.

Authors: Arslan, Muhammad; Xian, Haizhen; Shah, Imran; Aziz, Shahid; Jung, Dong-Won

Year: 2025

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-025-19792-z

Paper Design of experiments as a tool to guide the preparation of tailor-made activated carbons.

Schaubeder, Jana B; Guizani, Chamseddine; Selinger, Julian et al. · 2023 · Scientific reports · DOI

Full title: Design of experiments as a tool to guide the preparation of tailor-made activated carbons.

Authors: Schaubeder, Jana B; Guizani, Chamseddine; Selinger, Julian; Mautner, Andreas; Hummel, Michael; Spirk, Stefan

Year: 2023

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-023-30642-8

Paper Valorization of wood waste for enhanced polyhydroxybutyrate production by Klebsiella sp. MK3.

Kumar, Mukesh; Sachan, Rohan Samir Kumar; Karnwal, Arun et al. · 2025 · Scientific reports · DOI

Full title: Valorization of wood waste for enhanced polyhydroxybutyrate production by Klebsiella sp. MK3.

Authors: Kumar, Mukesh; Sachan, Rohan Samir Kumar; Karnwal, Arun; Sur, Dharmesh; Thakur, Rahul; Kumar, Abhinav; Manickkam, Sathiyamoorthy; Ayanie, Abinet Gosaye; Almujibah, Hamad

Year: 2025

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-025-01305-7

Paper A new evidence-based design-of-experiments approach for optimizing drug delivery systems with exemplification by emulsion-derived Vancomycin-loaded PLGA capsules.

Namdar, Ashkan; Borhanzadeh, Tina; Salahinejad, Erfan · 2024 · Scientific reports · DOI

Full title: A new evidence-based design-of-experiments approach for optimizing drug delivery systems with exemplification by emulsion-derived Vancomycin-loaded PLGA capsules.

Authors: Namdar, Ashkan; Borhanzadeh, Tina; Salahinejad, Erfan

Year: 2024

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-024-82496-3

Paper A multi-stage lithium-ion battery aging dataset using various experimental design methodologies.

Stroebl, Florian; Petersohn, Ronny; Schricker, Barbara et al. · 2024 · Scientific data · DOI

Full title: A multi-stage lithium-ion battery aging dataset using various experimental design methodologies.

Authors: Stroebl, Florian; Petersohn, Ronny; Schricker, Barbara; Schaeufl, Florian; Bohlen, Oliver; Palm, Herbert

Year: 2024

Venue: Scientific data

DOI: https://doi.org/10.1038/s41597-024-03859-z

Paper Single and multi-objective real-time optimisation of an industrial injection moulding process via a Bayesian adaptive design of experiment approach.

Kariminejad, Mandana; Tormey, David; Ryan, Caitríona et al. · 2024 · Scientific reports · DOI

Full title: Single and multi-objective real-time optimisation of an industrial injection moulding process via a Bayesian adaptive design of experiment approach.

Authors: Kariminejad, Mandana; Tormey, David; Ryan, Caitríona; O'Hara, Christopher; Weinert, Albert; McAfee, Marion

Year: 2024

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-024-80405-2

Paper AutoML based workflow for design of experiments (DOE) selection and benchmarking data acquisition strategies with simulation models.

Xu, Xukuan; Li, Donghui; Bi, Jinghou et al. · 2024 · Scientific reports · DOI

Full title: AutoML based workflow for design of experiments (DOE) selection and benchmarking data acquisition strategies with simulation models.

Authors: Xu, Xukuan; Li, Donghui; Bi, Jinghou; Moeckel, Michael

Year: 2024

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-024-83581-3

Paper Intelligent information management enables quality-by-design in pharmaceutical production.

Zhu, Zihan · 2025 · Scientific reports · DOI

Full title: Intelligent information management enables quality-by-design in pharmaceutical production.

Authors: Zhu, Zihan

Year: 2025

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-025-27879-w

Paper Design framework and optimization of portable biomedical waste decomposition systems using ANN and MOPSO.

Bhaiswar, Naresh N; Satputaley, Sushant S; Kadam, Sandeep M et al. · 2025 · Scientific reports · DOI

Full title: Design framework and optimization of portable biomedical waste decomposition systems using ANN and MOPSO.

Authors: Bhaiswar, Naresh N; Satputaley, Sushant S; Kadam, Sandeep M; Dinesha, P; Mohan, Sooraj

Year: 2025

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-025-33723-y

Paper Systematic optimization of human pluripotent stem cells media using Design of Experiments.

Marinho, Paulo A; Chailangkarn, Thanathom; Muotri, Alysson R · 2015 · Scientific reports · DOI

Full title: Systematic optimization of human pluripotent stem cells media using Design of Experiments.

Authors: Marinho, Paulo A; Chailangkarn, Thanathom; Muotri, Alysson R

Year: 2015

Venue: Scientific reports

DOI: https://doi.org/10.1038/srep09834

Paper DOE Optimization of Nano-based Carrier of Pregabalin as Hydrogel: New Therapeutic &Chemometric Approaches for Controlled Drug Delivery Systems.

Arafa, Mona G; Ayoub, Bassam M · 2017 · Scientific reports · DOI

Full title: DOE Optimization of Nano-based Carrier of Pregabalin as Hydrogel: New Therapeutic &Chemometric Approaches for Controlled Drug Delivery Systems.

Authors: Arafa, Mona G; Ayoub, Bassam M

Year: 2017

Venue: Scientific reports

DOI: https://doi.org/10.1038/srep41503

Paper Multi-response optimization of defined and undefined serum-free media for enhanced proliferation of immortalized lamb muscle cells.

Amirvaresi, Arian; Ovissipour, Reza · 2025 · Scientific reports · DOI

Full title: Multi-response optimization of defined and undefined serum-free media for enhanced proliferation of immortalized lamb muscle cells.

Authors: Amirvaresi, Arian; Ovissipour, Reza

Year: 2025

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-025-27508-6

Paper Application of a definitive screening design for the synthesis of a charge-transfer complex of sparfloxacin with tetracyanoethylene: spectroscopic, thermodynamic, kinetics, and DFT computational studies.

El-Shafie, Ahmed S; Khashan, Areej W; Hussein, Yasser H A et al. · 2019 · RSC advances · DOI

Full title: Application of a definitive screening design for the synthesis of a charge-transfer complex of sparfloxacin with tetracyanoethylene: spectroscopic, thermodynamic, kinetics, and DFT computational studies.

Authors: El-Shafie, Ahmed S; Khashan, Areej W; Hussein, Yasser H A; El-Azazy, Marwa

Year: 2019

Venue: RSC advances

DOI: https://doi.org/10.1039/c9ra03141c

Paper Machine learning and molecular descriptors enable rational solvent selection in asymmetric catalysis.

Amar, Yehia; Schweidtmann, Artur M; Deutsch, Paul et al. · 2019 · Chemical science · DOI

Full title: Machine learning and molecular descriptors enable rational solvent selection in asymmetric catalysis.

Authors: Amar, Yehia; Schweidtmann, Artur M; Deutsch, Paul; Cao, Liwei; Lapkin, Alexei

Year: 2019

Venue: Chemical science

DOI: https://doi.org/10.1039/c9sc01844a

Paper Statistical Optimization of Hydrazone-Crosslinked Hyaluronic Acid Hydrogels for Protein Delivery.

Mozipo, Esther A; Galindo, Alycia N; Khachatourian, Jenna D et al. · 2023 · bioRxiv : the preprint server for biology · DOI

Full title: Statistical Optimization of Hydrazone-Crosslinked Hyaluronic Acid Hydrogels for Protein Delivery.

Authors: Mozipo, Esther A; Galindo, Alycia N; Khachatourian, Jenna D; Harris, Conor G; Dorogin, Jonathan; Spaulding, Veronica R; Ford, Madeleine R; Singhal, Malvika; Fogg, Kaitlin C; Hettiaratchi, Marian H

Year: 2023

Venue: bioRxiv : the preprint server for biology

DOI: https://doi.org/10.1101/2023.07.14.549125

Paper The application of design of experiments (DoE) reaction optimisation and solvent selection in the development of new synthetic chemistry.

Murray, Paul M; Bellany, Fiona; Benhamou, Laure et al. · 2016 · Organic & biomolecular chemistry · DOI

Full title: The application of design of experiments (DoE) reaction optimisation and solvent selection in the development of new synthetic chemistry.

Authors: Murray, Paul M; Bellany, Fiona; Benhamou, Laure; Bučar, Dejan-Krešimir; Tabor, Alethea B; Sheppard, Tom D

Year: 2016

Venue: Organic & biomolecular chemistry

DOI: https://doi.org/10.1039/c5ob01892g

Paper Microfluidic synthesis of protein-loaded nanogels in a coaxial flow reactor using a design of experiments approach

Whiteley, Zoe; Ho, Hei Ming Kenneth; Gan, Yee Xin et al. · 2021 · Nanoscale Advances · DOI

Full title: Microfluidic synthesis of protein-loaded nanogels in a coaxial flow reactor using a design of experiments approach

Authors: Whiteley, Zoe; Ho, Hei Ming Kenneth; Gan, Yee Xin; Panariello, Luca; Gkogkos, Georgios; Gavriilidis, Asterios; Craig, Duncan Q.M.

Year: 2021

Venue: Nanoscale Advances

DOI: https://doi.org/10.1039/d0na01051k

Paper Development of a fluorescence-based assay for RecBCD activity using functional data analysis and design of experiments.

Winnifrith, Adam; Brown, Steven R; Jedryszek, Piotr et al. · 2025 · RSC chemical biology · DOI

Full title: Development of a fluorescence-based assay for RecBCD activity using functional data analysis and design of experiments.

Authors: Winnifrith, Adam; Brown, Steven R; Jedryszek, Piotr; Grant, C; Kay, Philip E; Thomas, Adam M; Bradbury, Jacob D; Lanyon-Hogg, Thomas

Year: 2025

Venue: RSC chemical biology

DOI: https://doi.org/10.1039/d4cb00291a

Paper Self-optimising processes and real-time-optimisation of organic syntheses in a microreactor system using Nelder–Mead and design of experiments

Fath, Verena; Kockmann, Norbert; Otto, Jürgen C. et al. · 2020 · Reaction Chemistry & Engineering · DOI

Full title: Self-optimising processes and real-time-optimisation of organic syntheses in a microreactor system using Nelder–Mead and design of experiments

Authors: Fath, Verena; Kockmann, Norbert; Otto, Jürgen C.; Röder, Thorsten

Year: 2020

Venue: Reaction Chemistry & Engineering

DOI: https://doi.org/10.1039/d0re00081g

Paper PEGylated lipid screening, composition optimization, and structure-activity relationship determination for lipid nanoparticle-mediated mRNA delivery.

Liu, Lingyun; Kim, Jae-Heon; Li, Zhongyu et al. · 2025 · Nanoscale · DOI

Full title: PEGylated lipid screening, composition optimization, and structure-activity relationship determination for lipid nanoparticle-mediated mRNA delivery.

Authors: Liu, Lingyun; Kim, Jae-Heon; Li, Zhongyu; Sun, Mengwei; Northen, Trent; Tang, Jackie; Mcintosh, Emma; Karve, Shrirang; DeRosa, Frank

Year: 2025

Venue: Nanoscale

DOI: https://doi.org/10.1039/d5nr00433k

Paper Harnessing data and control with AI/ML-driven polymerization and copolymerization.

Advincula, Rigoberto; Ivanov, Ilia; Vasudevan, Rama et al. · 2026 · Faraday discussions · DOI

Full title: Harnessing data and control with AI/ML-driven polymerization and copolymerization.

Authors: Advincula, Rigoberto; Ivanov, Ilia; Vasudevan, Rama; Kumar, Rajeev; Christakopoulos, Panagiotis; Tsakanika, Marileta; Chen, Jihua; Carillo, Jan Michael; Zhu, Qinyu; Sumpter, Bobby

Year: 2026

Venue: Faraday discussions

DOI: https://doi.org/10.1039/d5fd00066a

Paper Statistical optimization of cell-hydrogel interactions for green microbiology - a tutorial review.

Harris, Conor G; Semprini, Lewis; Rochefort, Willie E et al. · 2024 · RSC sustainability · DOI

Full title: Statistical optimization of cell-hydrogel interactions for green microbiology - a tutorial review.

Authors: Harris, Conor G; Semprini, Lewis; Rochefort, Willie E; Fogg, Kaitlin C

Year: 2024

Venue: RSC sustainability

DOI: https://doi.org/10.1039/d4su00400k

Paper The design of experiments (DoE) in optimization of an aerobic flow Pd-catalyzed oxidation of alcohol towards an important aldehyde precursor in the synthesis of phosphatidylinositide 3-kinase inhibitor (CPL302415).

Michałek, Stanisław; Gurba-Bryśkiewicz, Lidia; Maruszak, Wioleta et al. · 2022 · RSC advances · DOI

Full title: The design of experiments (DoE) in optimization of an aerobic flow Pd-catalyzed oxidation of alcohol towards an important aldehyde precursor in the synthesis of phosphatidylinositide 3-kinase inhibitor (CPL302415).

Authors: Michałek, Stanisław; Gurba-Bryśkiewicz, Lidia; Maruszak, Wioleta; Zagozda, Marcin; Maj, Anna M; Ochal, Zbigniew; Dubiel, Krzysztof; Wieczorek, Maciej

Year: 2022

Venue: RSC advances

DOI: https://doi.org/10.1039/d2ra07003k

Paper Combination of Ultrasound with Ammonification Pretreatment for the Fiber Composition of Corn Straw: a Predictive Model by Response Surface Methodology

Xiaoli Wei; Runtao Wang; Tengyu Qu et al. · 2019 · Journal of Physics: Conference Series · DOI

Full title: Combination of Ultrasound with Ammonification Pretreatment for the Fiber Composition of Corn Straw: a Predictive Model by Response Surface Methodology

Authors: Xiaoli Wei; Runtao Wang; Tengyu Qu; Gen li

Year: 2019

Venue: Journal of Physics: Conference Series

DOI: https://doi.org/10.1088/1742-6596/1169/1/012023

Paper Optimization of Bioleaching Process of High-Fluoride-Bearing Uranium by Response Surface Methodology

Xiang Li; Xiao-lan Mo; J. Wen et al. · 2019 · IOP Conference Series: Materials Science and Engineering · DOI

Full title: Optimization of Bioleaching Process of High-Fluoride-Bearing Uranium by Response Surface Methodology

Authors: Xiang Li; Xiao-lan Mo; J. Wen; Hong-ying Yang

Year: 2019

Venue: IOP Conference Series: Materials Science and Engineering

DOI: https://doi.org/10.1088/1757-899x/562/1/012100

Paper Optimization of Different Parameter in Synthesis Ion Imprinted Polymers via Precipitation Polymerization for Nitrate Adsorption

Noorhidayah Ishak; Teh Chin Xin; Azalina Mohamed Nasir et al. · 2020 · IOP Conference Series: Materials Science and Engineering · DOI

Full title: Optimization of Different Parameter in Synthesis Ion Imprinted Polymers via Precipitation Polymerization for Nitrate Adsorption

Authors: Noorhidayah Ishak; Teh Chin Xin; Azalina Mohamed Nasir; Shuit Siew Hoong

Year: 2020

Venue: IOP Conference Series: Materials Science and Engineering

DOI: https://doi.org/10.1088/1757-899x/864/1/012184

Paper Statistical optimization strategies on waste substrates for solving high-cost challenges in biosurfactants production: a review

Abimbola Bowofoluwa Sharon; E. Ahuekwe; Elughi Gift Nzubechi et al. · 2023 · IOP Conference Series: Earth and Environment · DOI

Full title: Statistical optimization strategies on waste substrates for solving high-cost challenges in biosurfactants production: a review

Authors: Abimbola Bowofoluwa Sharon; E. Ahuekwe; Elughi Gift Nzubechi; O. Oziegbe; M. Oniha

Year: 2023

Venue: IOP Conference Series: Earth and Environment

DOI: https://doi.org/10.1088/1755-1315/1197/1/012004

Paper 2-[(Hydroxymethyl)amino]ethanol in water as a preservative: Study of formaldehyde released by Taguchi's method

W. Wisessirikul; S. Loykulnant; S. Montha et al. · 2016 · Conf. Ser. · DOI

Full title: 2-[(Hydroxymethyl)amino]ethanol in water as a preservative: Study of formaldehyde released by Taguchi's method

Authors: W. Wisessirikul; S. Loykulnant; S. Montha; T. Fhulua; P. Prapainainar

Year: 2016

Venue: Conf. Ser.

DOI: https://doi.org/10.1088/1755-1315/36/1/012049

Paper Immobilization of cyclodextrin glucanotransferase on hollow fiber membrane: optimization of the immobilization parameters by response surface methodology

N. Jamil; R. C. Man; S. Suhaimi et al. · 2019 · IOP Conference Series: Earth and Environment · DOI

Full title: Immobilization of cyclodextrin glucanotransferase on hollow fiber membrane: optimization of the immobilization parameters by response surface methodology

Authors: N. Jamil; R. C. Man; S. Suhaimi; S. Shaarani; Z. I. M. Arshad; S. K. A. Mudalip; S. Z. Sulaiman

Year: 2019

Venue: IOP Conference Series: Earth and Environment

DOI: https://doi.org/10.1088/1755-1315/268/1/012008

Paper Response Surface Methodology for Optimization Studies of Microwave-assisted hydrodistillation of essential oil from Vietnamese Citrus aurantifolia (Lemon fruit)

T. Hien Tran; Tri Duc Lam; Van Tien Nguyen et al. · 2019 · IOP Conference Series: Materials Science and Engineering · DOI

Full title: Response Surface Methodology for Optimization Studies of Microwave-assisted hydrodistillation of essential oil from Vietnamese Citrus aurantifolia (Lemon fruit)

Authors: T. Hien Tran; Tri Duc Lam; Van Tien Nguyen; Tan Phat Dao; Le Thi Hong Nhan; Tran Quoc Toan; D. Vo; Tran Anh Vy; L. M. Bui

Year: 2019

Venue: IOP Conference Series: Materials Science and Engineering

DOI: https://doi.org/10.1088/1757-899x/542/1/012042

Paper Application of response surface methodology in optimization condition of anthocyanin extraction process of cocoa peel waste with Microwave Assisted Extraction Method (MAE)

I. Rahmawati; B. A. Fachri; Y. Manurung et al. · 2021 · Conf. Ser. · DOI

Full title: Application of response surface methodology in optimization condition of anthocyanin extraction process of cocoa peel waste with Microwave Assisted Extraction Method (MAE)

Authors: I. Rahmawati; B. A. Fachri; Y. Manurung; Nurtsulutsiyah; M. Reza

Year: 2021

Venue: Conf. Ser.

DOI: https://doi.org/10.1088/1755-1315/743/1/012091

Paper Optimization of the Extraction Process of Anti-Vibrio parahaemolyticus Active Substances from Coptidis Rhizoma (Huanglian)

Xintong Wang; Siya Guo; Zongyi Zhang et al. · 2020 · Journal of Physics: Conference Series · DOI

Full title: Optimization of the Extraction Process of Anti-Vibrio parahaemolyticus Active Substances from Coptidis Rhizoma (Huanglian)

Authors: Xintong Wang; Siya Guo; Zongyi Zhang; Qian Xu; Lei Guo

Year: 2020

Venue: Journal of Physics: Conference Series

DOI: https://doi.org/10.1088/1742-6596/1637/1/012108

Paper A design of experiments approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies.

Ruiter, F A A; Alexander, C; Rose, F R A J et al. · 2017 · Biomedical materials (Bristol, England) · DOI

Full title: A design of experiments approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies.

Authors: Ruiter, F A A; Alexander, C; Rose, F R A J; Segal, J I

Year: 2017

Venue: Biomedical materials (Bristol, England)

DOI: https://doi.org/10.1088/1748-605X/aa7b54

Paper Statistical Optimization of Hydrazone-Crosslinked Hyaluronic Acid Hydrogels for Protein Delivery.

Mozipo, Esther A; Galindo, Alycia N; Khachatourian, Jenna D et al. · 2023 · bioRxiv : the preprint server for biology · DOI

Full title: Statistical Optimization of Hydrazone-Crosslinked Hyaluronic Acid Hydrogels for Protein Delivery.

Year: 2023

Venue: bioRxiv : the preprint server for biology

DOI: https://doi.org/10.1101/2023.07.14.549125

Paper A dynamic method for the investigation of induced state metabolic capacities as a function of temperature.

Sagmeister, Patrick; Langemann, Timo; Wechselberger, Patrick et al. · 2013 · Microbial cell factories · DOI

Full title: A dynamic method for the investigation of induced state metabolic capacities as a function of temperature.

Authors: Sagmeister, Patrick; Langemann, Timo; Wechselberger, Patrick; Meitz, Andrea; Herwig, Christoph

Year: 2013

Venue: Microbial cell factories

DOI: https://doi.org/10.1186/1475-2859-12-94

Paper Optimisation of the synthesis of vancomycin-selective molecularly imprinted polymer nanoparticles using automatic photoreactor.

Muzyka, Kateryna; Karim, Khalku; Guerreiro, Antonio et al. · 2014 · Nanoscale research letters · DOI

Full title: Optimisation of the synthesis of vancomycin-selective molecularly imprinted polymer nanoparticles using automatic photoreactor.

Authors: Muzyka, Kateryna; Karim, Khalku; Guerreiro, Antonio; Poma, Alessandro; Piletsky, Sergey

Year: 2014

Venue: Nanoscale research letters

DOI: https://doi.org/10.1186/1556-276X-9-154

Paper Enhancing nitrilase production from Fusarium proliferatum using response surface methodology.

Yusuf, Farnaz; Chaubey, Asha; Raina, Arvind et al. · 2013 · SpringerPlus · DOI

Full title: Enhancing nitrilase production from Fusarium proliferatum using response surface methodology.

Authors: Yusuf, Farnaz; Chaubey, Asha; Raina, Arvind; Jamwal, Urmila; Parshad, Rajinder

Year: 2013

Venue: SpringerPlus

DOI: https://doi.org/10.1186/2193-1801-2-290

Paper Optimization of ultrasonic extraction of polysaccharides from Ziziphus jujuba Mill. by response surface methodology.

Qu, Chenling; Yu, Songcheng; Luo, Li et al. · 2013 · Chemistry Central journal · DOI

Full title: Optimization of ultrasonic extraction of polysaccharides from Ziziphus jujuba Mill. by response surface methodology.

Authors: Qu, Chenling; Yu, Songcheng; Luo, Li; Zhao, Yan; Huang, Yawei

Year: 2013

Venue: Chemistry Central journal

DOI: https://doi.org/10.1186/1752-153X-7-160

Paper Optimization of protein production by Micrococcus luteus for exploring pollutant-degrading uncultured bacteria.

Su, Xiaomei; Liu, Yindong; Hu, Jinxing et al. · 2014 · SpringerPlus · DOI

Full title: Optimization of protein production by Micrococcus luteus for exploring pollutant-degrading uncultured bacteria.

Authors: Su, Xiaomei; Liu, Yindong; Hu, Jinxing; Ding, Linxian; Shen, Chaofeng

Year: 2014

Venue: SpringerPlus

DOI: https://doi.org/10.1186/2193-1801-3-117

Paper Developing a scalable model of recombinant protein yield from Pichia pastoris: the influence of culture conditions, biomass and induction regime.

Holmes, William J; Darby, Richard Aj; Wilks, Martin Db et al. · 2009 · Microbial cell factories · DOI

Full title: Developing a scalable model of recombinant protein yield from Pichia pastoris: the influence of culture conditions, biomass and induction regime.

Authors: Holmes, William J; Darby, Richard Aj; Wilks, Martin Db; Smith, Rodney; Bill, Roslyn M

Year: 2009

Venue: Microbial cell factories

DOI: https://doi.org/10.1186/1475-2859-8-35

Paper Influência de diferentes meios de cultura em cultivos de Streptococcus pneumoniae sorotipo 1 para produção de polissacarídeo capsular.

Bruno Vitório Marthos · 2012 · DOI

Full title: Influência de diferentes meios de cultura em cultivos de Streptococcus pneumoniae sorotipo 1 para produção de polissacarídeo capsular.

Authors: Bruno Vitório Marthos

Year: 2012

DOI: https://doi.org/10.11606/d.87.2012.tde-30102012-161733

Paper Enhanced cell disruption strategy in the release of recombinant hepatitis B surface antigen from Pichia pastoris using response surface methodology

Y. J. Tam; Z. Allaudin; M. Lila et al. · 2012 · BMC Biotechnology · DOI

Full title: Enhanced cell disruption strategy in the release of recombinant hepatitis B surface antigen from Pichia pastoris using response surface methodology

Authors: Y. J. Tam; Z. Allaudin; M. Lila; A. R. Bahaman; J. Tan; M. Rezaei

Year: 2012

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-12-70

Paper Optimization of production of the anti-keratin 8 single-chain Fv TS1-218 in Pichia pastoris using design of experiments

Jafari, Rozbeh; Sundström, Birgitta; Holm, Patrik · 2011 · Microbial Cell Factories · DOI

Full title: Optimization of production of the anti-keratin 8 single-chain Fv TS1-218 in Pichia pastoris using design of experiments

Authors: Jafari, Rozbeh; Sundström, Birgitta; Holm, Patrik

Year: 2011

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-10-34

Paper Climbing the mountain: experimental design for the efficient optimization of stem cell bioprocessing.

Toms, Derek; Deardon, Rob; Ungrin, Mark · 2017 · Journal of biological engineering · DOI

Full title: Climbing the mountain: experimental design for the efficient optimization of stem cell bioprocessing.

Authors: Toms, Derek; Deardon, Rob; Ungrin, Mark

Year: 2017

Venue: Journal of biological engineering

DOI: https://doi.org/10.1186/s13036-017-0078-z

Paper Optimization of a recombinant BlaR-CTD protein formulation using the response surface methodology.

Abdolvahab, Mohadeseh Haji; Safari, Mojdeh; Hasannejad, Farkhonde et al. · 2024 · Journal of biological engineering · DOI

Full title: Optimization of a recombinant BlaR-CTD protein formulation using the response surface methodology.

Authors: Abdolvahab, Mohadeseh Haji; Safari, Mojdeh; Hasannejad, Farkhonde; Asefi, Nika; Salimi, Alireza; Nazari, Mahboobeh

Year: 2024

Venue: Journal of biological engineering

DOI: https://doi.org/10.1186/s13036-023-00399-9

Paper Improved production of andrimid in Erwinia persicina BST187 strain by fermentation optimization.

Cheng, Tingfeng; Ge, Tongling; Zhao, Lunqiang et al. · 2023 · BMC microbiology · DOI

Full title: Improved production of andrimid in Erwinia persicina BST187 strain by fermentation optimization.

Authors: Cheng, Tingfeng; Ge, Tongling; Zhao, Lunqiang; Hou, Yuyong; Xia, Jianye; Zhao, Lei

Year: 2023

Venue: BMC microbiology

DOI: https://doi.org/10.1186/s12866-023-02946-2

Paper Use of a design of experiments approach to optimise production of a recombinant antibody fragment in the periplasm of Escherichia coli: selection of signal peptide and optimal growth conditions.

Kasli, Ikhlaas M; Thomas, Owen R T; Overton, Tim W · 2019 · AMB Express · DOI

Full title: Use of a design of experiments approach to optimise production of a recombinant antibody fragment in the periplasm of Escherichia coli: selection of signal peptide and optimal growth conditions.

Authors: Kasli, Ikhlaas M; Thomas, Owen R T; Overton, Tim W

Year: 2019

Venue: AMB Express

DOI: https://doi.org/10.1186/s13568-018-0727-8

Paper Cell factory for γ-aminobutyric acid (GABA) production using Bifidobacterium adolescentis

Hend Altaib; Tomoya Kozakai; Y. Badr et al. · 2022 · Microbial Cell Factories · DOI

Full title: Cell factory for γ-aminobutyric acid (GABA) production using Bifidobacterium adolescentis

Authors: Hend Altaib; Tomoya Kozakai; Y. Badr; Hazuki Nakao; Mahmoud A. M. El-Nouby; Emiko Yanase; Izumi Nomura; Tohru Suzuki

Year: 2022

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-021-01729-6

Paper Optimal process design space to ensure maximum viability and productivity in Penicillium chrysogenum pellets during fed-batch cultivations through morphological and physiological control.

Veiter, Lukas; Kager, Julian; Herwig, Christoph · 2020 · Microbial cell factories · DOI

Full title: Optimal process design space to ensure maximum viability and productivity in Penicillium chrysogenum pellets during fed-batch cultivations through morphological and physiological control.

Authors: Veiter, Lukas; Kager, Julian; Herwig, Christoph

Year: 2020

Venue: Microbial cell factories

DOI: https://doi.org/10.1186/s12934-020-1288-5

Paper Optimization of tenocyte lineage-related factors from tonsil-derived mesenchymal stem cells using response surface methodology.

Kwon, Soon-Sun; Kim, Hyang; Shin, Sang-Jin et al. · 2020 · Journal of orthopaedic surgery and research · DOI

Full title: Optimization of tenocyte lineage-related factors from tonsil-derived mesenchymal stem cells using response surface methodology.

Authors: Kwon, Soon-Sun; Kim, Hyang; Shin, Sang-Jin; Lee, Seung Yeol

Year: 2020

Venue: Journal of orthopaedic surgery and research

DOI: https://doi.org/10.1186/s13018-020-01623-8

Paper Optimization of medium compositions to improve a novel glycoprotein production by Streptomyces kanasenisi ZX01.

Zhou, Yong; Sun, Yu-Bo; He, Hong-Wei et al. · 2017 · AMB Express · DOI

Full title: Optimization of medium compositions to improve a novel glycoprotein production by Streptomyces kanasenisi ZX01.

Authors: Zhou, Yong; Sun, Yu-Bo; He, Hong-Wei; Feng, Jun-Tao; Zhang, Xing; Han, Li-Rong

Year: 2017

Venue: AMB Express

DOI: https://doi.org/10.1186/s13568-016-0316-7

Paper Optimization of laccase production from Marasmiellus palmivorus LA1 by Taguchi method of Design of experiments.

Chenthamarakshan, Aiswarya; Parambayil, Nayana; Miziriya, Nafeesathul et al. · 2017 · BMC biotechnology · DOI

Full title: Optimization of laccase production from Marasmiellus palmivorus LA1 by Taguchi method of Design of experiments.

Authors: Chenthamarakshan, Aiswarya; Parambayil, Nayana; Miziriya, Nafeesathul; Soumya, P S; Lakshmi, M S Kiran; Ramgopal, Anala; Dileep, Anuja; Nambisan, Padma

Year: 2017

Venue: BMC biotechnology

DOI: https://doi.org/10.1186/s12896-017-0333-x

Paper Modeling the dependence of respiration and photosynthesis upon light, acetate, carbon dioxide, nitrate and ammonium in Chlamydomonas reinhardtii using design of experiments and multiple regression.

Gérin, Stéphanie; Mathy, Grégory; Franck, Fabrice · 2014 · BMC systems biology · DOI

Full title: Modeling the dependence of respiration and photosynthesis upon light, acetate, carbon dioxide, nitrate and ammonium in Chlamydomonas reinhardtii using design of experiments and multiple regression.

Authors: Gérin, Stéphanie; Mathy, Grégory; Franck, Fabrice

Year: 2014

Venue: BMC systems biology

DOI: https://doi.org/10.1186/s12918-014-0096-0

Paper Combinatorial engineering pinpoints shikimate pathway bottlenecks in para-aminobenzoic acid production in Pseudomonas putida.

Campos-Magaña, Marco A; Moreno-Paz, Sara; Martin-Pascual, Maria et al. · 2025 · Journal of biological engineering · DOI

Full title: Combinatorial engineering pinpoints shikimate pathway bottlenecks in para-aminobenzoic acid production in Pseudomonas putida.

Authors: Campos-Magaña, Marco A; Moreno-Paz, Sara; Martin-Pascual, Maria; Martins Dos Santos, Vitor Ap; Garcia-Morales, Luis; Suarez-Diez, Maria

Year: 2025

Venue: Journal of biological engineering

DOI: https://doi.org/10.1186/s13036-025-00553-5

Paper Screening for efficient nitrogen sources for overproduction of the biomass of the functionally probiotic L. plantarum strain RPR42 in a cane molasses-based medium.

Papizadeh, Moslem; Rohani, Mahdi; Hosseini, Seyed Nezamedin et al. · 2020 · AMB Express · DOI

Full title: Screening for efficient nitrogen sources for overproduction of the biomass of the functionally probiotic L. plantarum strain RPR42 in a cane molasses-based medium.

Authors: Papizadeh, Moslem; Rohani, Mahdi; Hosseini, Seyed Nezamedin; Shojaosadati, Seyed Abbas; Nahrevanian, Hossein; Talebi, Malihe; Pourshafie, Mohammad Reza

Year: 2020

Venue: AMB Express

DOI: https://doi.org/10.1186/s13568-020-00976-x

Paper A numerical compass for experiment design in chemical kinetics and molecular property estimation.

Krüger, Matteo; Mishra, Ashmi; Spichtinger, Peter et al. · 2024 · Journal of cheminformatics · DOI

Full title: A numerical compass for experiment design in chemical kinetics and molecular property estimation.

Authors: Krüger, Matteo; Mishra, Ashmi; Spichtinger, Peter; Pöschl, Ulrich; Berkemeier, Thomas

Year: 2024

Venue: Journal of cheminformatics

DOI: https://doi.org/10.1186/s13321-024-00825-0

Paper Optimization and characterization of spray-dried IgG formulations: a design of experiment approach

Faghihi, Homa; Najafabadi, Abdolhosein Rouholamini; Vatanara, Alireza · 2017 · DARU Journal of Pharmaceutical Sciences · DOI

Full title: Optimization and characterization of spray-dried IgG formulations: a design of experiment approach

Authors: Faghihi, Homa; Najafabadi, Abdolhosein Rouholamini; Vatanara, Alireza

Year: 2017

Venue: DARU Journal of Pharmaceutical Sciences

DOI: https://doi.org/10.1186/s40199-017-0187-8

Paper Addressing bioreactor hiPSC aggregate stability, maintenance and scaleup challenges using a design of experiment approach.

Yehya, Haneen; Raudins, Sofija; Padmanabhan, Roshan et al. · 2024 · Stem cell research & therapy · DOI

Full title: Addressing bioreactor hiPSC aggregate stability, maintenance and scaleup challenges using a design of experiment approach.

Authors: Yehya, Haneen; Raudins, Sofija; Padmanabhan, Roshan; Jensen, Jan; Bukys, Michael A

Year: 2024

Venue: Stem cell research & therapy

DOI: https://doi.org/10.1186/s13287-024-03802-4

Paper Optimising environmental factors for maximal lactate productivity in Synechocystis sp. PCC 6803 through a design of experiments approach.

Faulkner, Matthew; Andrews, Fraser; Scrutton, Nigel S · 2025 · Biotechnology for biofuels and bioproducts · DOI

Full title: Optimising environmental factors for maximal lactate productivity in Synechocystis sp. PCC 6803 through a design of experiments approach.

Authors: Faulkner, Matthew; Andrews, Fraser; Scrutton, Nigel S

Year: 2025

Venue: Biotechnology for biofuels and bioproducts

DOI: https://doi.org/10.1186/s13068-025-02718-2

Paper Design of experiments to assess the effect of culture parameters on the osteogenic differentiation of human adipose stromal cells.

Kuterbekov, Mirasbek; Machillot, Paul; Baillet, Francis et al. · 2019 · Stem cell research & therapy · DOI

Full title: Design of experiments to assess the effect of culture parameters on the osteogenic differentiation of human adipose stromal cells.

Authors: Kuterbekov, Mirasbek; Machillot, Paul; Baillet, Francis; Jonas, Alain M; Glinel, Karine; Picart, Catherine

Year: 2019

Venue: Stem cell research & therapy

DOI: https://doi.org/10.1186/s13287-019-1333-7

Paper Indirect optimization of staphylokinase expression level in dicistronic auto-inducible system.

Shariati, Fatemeh Sadat; Keramati, Malihe; Cohan, Reza Ahangari · 2022 · AMB Express · DOI

Full title: Indirect optimization of staphylokinase expression level in dicistronic auto-inducible system.

Authors: Shariati, Fatemeh Sadat; Keramati, Malihe; Cohan, Reza Ahangari

Year: 2022

Venue: AMB Express

DOI: https://doi.org/10.1186/s13568-022-01464-0

Paper Effective flow-through polishing strategies for knob-into-hole bispecific antibodies.

Chen, Serene W; Hoi, Kong Meng; Mahfut, Farouq Bin et al. · 2022 · Bioresources and bioprocessing · DOI

Full title: Effective flow-through polishing strategies for knob-into-hole bispecific antibodies.

Authors: Chen, Serene W; Hoi, Kong Meng; Mahfut, Farouq Bin; Yang, Yuansheng; Zhang, Wei

Year: 2022

Venue: Bioresources and bioprocessing

DOI: https://doi.org/10.1186/s40643-022-00590-8

Paper Defined YNB-free mineral medium improves reproducibility and enables high-titer production in Yarrowia lipolytica.

Dietrich, Demian; Qi, Hang; Jovanovic Gasovic, Sofija et al. · 2026 · Microbial cell factories · DOI

Full title: Defined YNB-free mineral medium improves reproducibility and enables high-titer production in Yarrowia lipolytica.

Authors: Dietrich, Demian; Qi, Hang; Jovanovic Gasovic, Sofija; Kohlstedt, Michael; Wittmann, Christoph

Year: 2026

Venue: Microbial cell factories

DOI: https://doi.org/10.1186/s12934-026-02939-6

Paper Design and Analysis of Experiments with R

Lawson, John · 2014 · DOI

Full title: Design and Analysis of Experiments with R

Authors: Lawson, John

Year: 2014

DOI: https://doi.org/10.1201/b17883

Paper Design of Experiments

Fisher, Ronald Aylmer · 1936 · BMJ · DOI

Full title: Design of Experiments

Authors: Fisher, Ronald Aylmer

Year: 1936

Venue: BMJ

DOI: https://doi.org/10.1136/bmj.1.3923.554-a

Paper Statistical Design of Experiments with Engineering Applications

Rekab, Kamel; Shaikh, Muzaffar · 2005 · DOI

Full title: Statistical Design of Experiments with Engineering Applications

Authors: Rekab, Kamel; Shaikh, Muzaffar

Year: 2005

DOI: https://doi.org/10.1201/b16326

Paper Design and Modeling for Computer Experiments

Fang, K.-T.; Li, Run-ze; Sudjianto, Agus · 2005 · DOI

Full title: Design and Modeling for Computer Experiments

Authors: Fang, K.-T.; Li, Run-ze; Sudjianto, Agus

Year: 2005

DOI: https://doi.org/10.1201/9781420034899

Paper The Theory of the Design of Experiments

Cox, D. R.; Reid, Nancy · 2000 · DOI

Full title: The Theory of the Design of Experiments

Authors: Cox, D. R.; Reid, Nancy

Year: 2000

DOI: https://doi.org/10.1201/9781420035834

Paper Preparation, Characterization, and Optimization of Folic Acid-Chitosan-Methotrexate Core-Shell Nanoparticles by Box-Behnken Design for Tumor-Targeted Drug Delivery.

Naghibi Beidokhti, Hamid Reza; Ghaffarzadegan, Reza; Mirzakhanlouei, Sasan et al. · 2017 · AAPS PharmSciTech · DOI

Full title: Preparation, Characterization, and Optimization of Folic Acid-Chitosan-Methotrexate Core-Shell Nanoparticles by Box-Behnken Design for Tumor-Targeted Drug Delivery.

Authors: Naghibi Beidokhti, Hamid Reza; Ghaffarzadegan, Reza; Mirzakhanlouei, Sasan; Ghazizadeh, Leila; Dorkoosh, Farid Abedin

Year: 2017

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-015-0445-3

Paper Machine Learning-Enabled NIR Spectroscopy. Part 3: Hyperparameter by Design (HyD) Based ANN-MLP Optimization, Model Generalizability, and Model Transferability.

Ali, Hussain; Muthudoss, Prakash; Chauhan, Chirag et al. · 2023 · AAPS PharmSciTech · DOI

Full title: Machine Learning-Enabled NIR Spectroscopy. Part 3: Hyperparameter by Design (HyD) Based ANN-MLP Optimization, Model Generalizability, and Model Transferability.

Authors: Ali, Hussain; Muthudoss, Prakash; Chauhan, Chirag; Kaliappan, Ilango; Kumar, Dinesh; Paudel, Amrit; Ramasamy, Gobi

Year: 2023

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-023-02697-3

Paper Effect of Percent Relative Humidity, Moisture Content, and Compression Force on Light-Induced Fluorescence (LIF) Response as a Process Analytical Tool.

Shah, Ishan G; Stagner, William C · 2016 · AAPS PharmSciTech · DOI

Full title: Effect of Percent Relative Humidity, Moisture Content, and Compression Force on Light-Induced Fluorescence (LIF) Response as a Process Analytical Tool.

Authors: Shah, Ishan G; Stagner, William C

Year: 2016

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-015-0420-z

Paper Automated discovery of novel drug formulations using predictive iterated high throughput experimentation.

Caschera, Filippo; Gazzola, Gianluca; Bedau, Mark A et al. · 2010 · PloS one · DOI

Full title: Automated discovery of novel drug formulations using predictive iterated high throughput experimentation.

Authors: Caschera, Filippo; Gazzola, Gianluca; Bedau, Mark A; Bosch Moreno, Carolina; Buchanan, Andrew; Cawse, James; Packard, Norman; Hanczyc, Martin M

Year: 2010

Venue: PloS one

DOI: https://doi.org/10.1371/journal.pone.0008546

Paper Design space construction of multiple dose-strength tablets utilizing bayesian estimation based on one set of design-of-experiments.

Maeda, Jin; Suzuki, Tatsuya; Takayama, Kozo · 2012 · Chemical & pharmaceutical bulletin · DOI

Full title: Design space construction of multiple dose-strength tablets utilizing bayesian estimation based on one set of design-of-experiments.

Authors: Maeda, Jin; Suzuki, Tatsuya; Takayama, Kozo

Year: 2012

Venue: Chemical & pharmaceutical bulletin

DOI: https://doi.org/10.1248/cpb.c12-00491

Paper Optimization Using Response Surface Methodology for Biodiesel Production by Double-Pipe Static Mixer Reactor

Wissarut Attahiran; Kulchanat Prasertsit; Songtham Photaworn · 2024 · Journal of Ecological Engineering · DOI

Full title: Optimization Using Response Surface Methodology for Biodiesel Production by Double-Pipe Static Mixer Reactor

Authors: Wissarut Attahiran; Kulchanat Prasertsit; Songtham Photaworn

Year: 2024

Venue: Journal of Ecological Engineering

DOI: https://doi.org/10.12911/22998993/183956

Paper Statistical modeling, optimization and characterization of spray-dried solid self-microemulsifying drug delivery system using design of experiments.

Marasini, Nirmal; Tran, Tuan Hiep; Poudel, Bijay Kumar et al. · 2013 · Chemical & pharmaceutical bulletin · DOI

Full title: Statistical modeling, optimization and characterization of spray-dried solid self-microemulsifying drug delivery system using design of experiments.

Authors: Marasini, Nirmal; Tran, Tuan Hiep; Poudel, Bijay Kumar; Choi, Han-Gon; Yong, Chul Soon; Kim, Jong Oh

Year: 2013

Venue: Chemical & pharmaceutical bulletin

DOI: https://doi.org/10.1248/cpb.c12-00823

Paper Practical adoption of state-of-the-art hiPSC-cardiomyocyte differentiation techniques.

Rupert, Cassady E; Irofuala, Chinedu; Coulombe, Kareen L K · 2020 · PloS one · DOI

Full title: Practical adoption of state-of-the-art hiPSC-cardiomyocyte differentiation techniques.

Authors: Rupert, Cassady E; Irofuala, Chinedu; Coulombe, Kareen L K

Year: 2020

Venue: PloS one

DOI: https://doi.org/10.1371/journal.pone.0230001

Paper Determining the Influence of Granule Size on Simulation Parameters and Residual Shear Stress Distribution in Tablets by Combining the Finite Element Method into the Design of Experiments.

Hayashi, Yoshihiro; Kosugi, Atsushi; Miura, Takahiro et al. · 2018 · Chemical & pharmaceutical bulletin · DOI

Full title: Determining the Influence of Granule Size on Simulation Parameters and Residual Shear Stress Distribution in Tablets by Combining the Finite Element Method into the Design of Experiments.

Authors: Hayashi, Yoshihiro; Kosugi, Atsushi; Miura, Takahiro; Takayama, Kozo; Onuki, Yoshinori

Year: 2018

Venue: Chemical & pharmaceutical bulletin

DOI: https://doi.org/10.1248/cpb.c17-00955

Paper Novel method for constructing a large-scale design space in lubrication process by using Bayesian estimation based on the reliability of a scale-up rule.

Maeda, Jin; Suzuki, Tatsuya; Takayama, Kozo · 2012 · Chemical & pharmaceutical bulletin · DOI

Full title: Novel method for constructing a large-scale design space in lubrication process by using Bayesian estimation based on the reliability of a scale-up rule.

Authors: Maeda, Jin; Suzuki, Tatsuya; Takayama, Kozo

Year: 2012

Venue: Chemical & pharmaceutical bulletin

DOI: https://doi.org/10.1248/cpb.c12-00340

Paper Application of design of experiments and multilayer perceptrons neural network in the optimization of diclofenac sodium extended release tablets with Carbopol 71G.

Ivić, Branka; Ibrić, Svetlana; Cvetković, Nebojsa et al. · 2010 · Chemical & pharmaceutical bulletin · DOI

Full title: Application of design of experiments and multilayer perceptrons neural network in the optimization of diclofenac sodium extended release tablets with Carbopol 71G.

Authors: Ivić, Branka; Ibrić, Svetlana; Cvetković, Nebojsa; Petrović, Aleksandra; Trajković, Svetlana; Djurić, Zorica

Year: 2010

Venue: Chemical & pharmaceutical bulletin

DOI: https://doi.org/10.1248/cpb.58.947

Paper Design of Experiments to Study the Impact of Process Parameters on Droplet Size and Development of Non-Invasive Imaging Techniques in Tablet Coating.

Dennison, Thomas J; Smith, Julian; Hofmann, Michael P et al. · 2016 · PloS one · DOI

Full title: Design of Experiments to Study the Impact of Process Parameters on Droplet Size and Development of Non-Invasive Imaging Techniques in Tablet Coating.

Authors: Dennison, Thomas J; Smith, Julian; Hofmann, Michael P; Bland, Charlotte E; Badhan, Raj K; Al-Khattawi, Ali; Mohammed, Afzal R

Year: 2016

Venue: PloS one

DOI: https://doi.org/10.1371/journal.pone.0157267

Paper Optimization of Low-Temperature Methanol Crystallization for Unsaturated Fatty Acids Separation from Crude Palm Fatty Acids Mixture Using Response Surface Methodology

M. Bahadi; Mohamad Firdaus Yusoff; J. Salimon et al. · 2019 · Asian Journal of Chemistry · DOI

Full title: Optimization of Low-Temperature Methanol Crystallization for Unsaturated Fatty Acids Separation from Crude Palm Fatty Acids Mixture Using Response Surface Methodology

Authors: M. Bahadi; Mohamad Firdaus Yusoff; J. Salimon; A. A. Japir; D. Derawi

Year: 2019

Venue: Asian Journal of Chemistry

DOI: https://doi.org/10.14233/ajchem.2019.21974

Paper Statistical experimental design guided optimization of a one-pot biphasic multienzyme total synthesis of amorpha-4,11-diene.

Chen, Xixian; Zhang, Congqiang; Zou, Ruiyang et al. · 2013 · PloS one · DOI

Full title: Statistical experimental design guided optimization of a one-pot biphasic multienzyme total synthesis of amorpha-4,11-diene.

Authors: Chen, Xixian; Zhang, Congqiang; Zou, Ruiyang; Zhou, Kang; Stephanopoulos, Gregory; Too, Heng Phon

Year: 2013

Venue: PloS one

DOI: https://doi.org/10.1371/journal.pone.0079650

Paper Controllability analysis of protein glycosylation in CHO cells.

St Amand, Melissa M; Tran, Kevin; Radhakrishnan, Devesh et al. · 2014 · PloS one · DOI

Full title: Controllability analysis of protein glycosylation in CHO cells.

Authors: St Amand, Melissa M; Tran, Kevin; Radhakrishnan, Devesh; Robinson, Anne S; Ogunnaike, Babatunde A

Year: 2014

Venue: PloS one

DOI: https://doi.org/10.1371/journal.pone.0087973

Paper Optimization of UV irradiation mutation conditions for cellulase production by mutant fungal strains of Aspergillus niger through solid state fermentation

Nahideh Jafari; Hoda Jafarizadeh-Malmiri; Maryam Hamzeh-Mivehroud et al. · 2017 · DOI

Full title: Optimization of UV irradiation mutation conditions for cellulase production by mutant fungal strains of Aspergillus niger through solid state fermentation

Authors: Nahideh Jafari; Hoda Jafarizadeh-Malmiri; Maryam Hamzeh-Mivehroud; M. Adibpour

Year: 2017

DOI: https://doi.org/10.1515/gps-2016-0145

Paper Design of experiments in liquid chromatography (HPLC) analysis of pharmaceuticals: analytics, applications, implications and future prospects

Ganorkar, Saurabh B.; Shirkhedkar, Atul A. · 2017 · Reviews in Analytical Chemistry · DOI

Full title: Design of experiments in liquid chromatography (HPLC) analysis of pharmaceuticals: analytics, applications, implications and future prospects

Authors: Ganorkar, Saurabh B.; Shirkhedkar, Atul A.

Year: 2017

Venue: Reviews in Analytical Chemistry

DOI: https://doi.org/10.1515/revac-2016-0025

Paper Production of Reducing Sugar from Oil Palm Empty Fruit Bunch (EFB) Cellulose Fibres via Acid Hydrolysis

S. Chin; C. Chia; S. Zakaria · 2012 · DOI

Full title: Production of Reducing Sugar from Oil Palm Empty Fruit Bunch (EFB) Cellulose Fibres via Acid Hydrolysis

Authors: S. Chin; C. Chia; S. Zakaria

Year: 2012

DOI: https://doi.org/10.15376/biores.8.1.447-460

Paper RECURSIVE CO-KRIGING MODEL FOR DESIGN OF COMPUTER EXPERIMENTS WITH MULTIPLE LEVELS OF FIDELITY

Gratiet, Loïc Le; Garnier, Josselin · 2014 · International Journal for Uncertainty Quantification · DOI

Full title: RECURSIVE CO-KRIGING MODEL FOR DESIGN OF COMPUTER EXPERIMENTS WITH MULTIPLE LEVELS OF FIDELITY

Authors: Gratiet, Loïc Le; Garnier, Josselin

Year: 2014

Venue: International Journal for Uncertainty Quantification

DOI: https://doi.org/10.1615/int.j.uncertaintyquantification.2014006914

Paper Encapsulation of Eucalyptus tereticornis extract in polylactic-co-glycolic acid nanoparticles: standardization, optimization and cell viability.

Maria C Cely-Garcia; Diana Y Espinel-Pabón; Nancy Jaimes-Mendez et al. · 2025 · Anais da Academia Brasileira de Ciências · DOI

Full title: Encapsulation of Eucalyptus tereticornis extract in polylactic-co-glycolic acid nanoparticles: standardization, optimization and cell viability.

Authors: Maria C Cely-Garcia; Diana Y Espinel-Pabón; Nancy Jaimes-Mendez; Norman Balcazar-Morales; Edwin A Murillo-Ruiz

Year: 2025

Venue: Anais da Academia Brasileira de Ciências

DOI: https://doi.org/10.1590/0001-3765202520241069

Paper Design of Experiments (DoE) applied to Pharmaceutical and Analytical Quality by Design (QbD)

Fukuda, Isa Martins; Pinto, Camila Francini Fidelis; Moreira, Camila dos Santos et al. · 2018 · Brazilian Journal of Pharmaceutical Sciences · DOI

Full title: Design of Experiments (DoE) applied to Pharmaceutical and Analytical Quality by Design (QbD)

Authors: Fukuda, Isa Martins; Pinto, Camila Francini Fidelis; Moreira, Camila dos Santos; Saviano, Alessandro Morais; Lourenço, Felipe Rebello

Year: 2018

Venue: Brazilian Journal of Pharmaceutical Sciences

DOI: https://doi.org/10.1590/s2175-97902018000001006

Paper Application of statistical experimental design for optimisation of bioinsecticides production by sporeless Bacillus thuringiensis strain on cheap medium.

Ben Khedher, Saoussen; Jaoua, Samir; Zouari, Nabil · 2013 · Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · DOI

Full title: Application of statistical experimental design for optimisation of bioinsecticides production by sporeless Bacillus thuringiensis strain on cheap medium.

Authors: Ben Khedher, Saoussen; Jaoua, Samir; Zouari, Nabil

Year: 2013

Venue: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]

DOI: https://doi.org/10.1590/s1517-83822013000300043

Paper Effect of Extraction Conditions of Green Tea on Antioxidant Activity and EGCG Content: Optimization using Response Surface Methodology

Mun Jun Kim; J. Ahn; S. Kim et al. · 2016 · DOI

Full title: Effect of Extraction Conditions of Green Tea on Antioxidant Activity and EGCG Content: Optimization using Response Surface Methodology

Authors: Mun Jun Kim; J. Ahn; S. Kim; Y. Jo; Qing Liu; B. Hwang; M. Lee

Year: 2016

DOI: https://doi.org/10.20307/nps.2016.22.4.270

Paper Data-Driven Process Optimization Using AI and Statistical Methods in High-Tech Manufacturing

Gaurav Rajendra Parashare · 2024 · International Journal of Scientific Research and Management · DOI

Full title: Data-Driven Process Optimization Using AI and Statistical Methods in High-Tech Manufacturing

Authors: Gaurav Rajendra Parashare

Year: 2024

Venue: International Journal of Scientific Research and Management

DOI: https://doi.org/10.18535/ijsrm/v12i12.ec09

Paper Developing a Cell Culture Protocol to Induce Quiescence in Intestinal Fibroblasts Using Design of Experiments Statistical Optimization.

Mohammadalizadeh, Zahra; Estrada, Katherine Bauer; Almonte, Morgenne et al. · 2025 · Research square · DOI

Full title: Developing a Cell Culture Protocol to Induce Quiescence in Intestinal Fibroblasts Using Design of Experiments Statistical Optimization.

Authors: Mohammadalizadeh, Zahra; Estrada, Katherine Bauer; Almonte, Morgenne; Fogg, Kaitlin C; Porras, Ana M

Year: 2025

Venue: Research square

DOI: https://doi.org/10.21203/rs.3.rs-7677632/v1

Paper Development of a thermostable nanoemulsion adjuvanted vaccine against tuberculosis using a design-of-experiments approach

Kramer, Ryan M.; Archer, Michelle; Orr, Mark T. et al. · 2018 · International Journal of Nanomedicine · DOI

Full title: Development of a thermostable nanoemulsion adjuvanted vaccine against tuberculosis using a design-of-experiments approach

Authors: Kramer, Ryan M.; Archer, Michelle; Orr, Mark T.; Cauwelaert, Natasha Dubois; Beebe, Elyse A.; Huang, Po‐Wei; Dowling, Quinton M.; Schwartz, Alicia M.; Fedor, Dawn M.; Vedvick, Thomas S.; Fox, Christopher B.

Year: 2018

Venue: International Journal of Nanomedicine

DOI: https://doi.org/10.2147/ijn.s159839

Paper DESIGN OF EXPERIMENTS MODEL FOR THE OPTIMIZATION OF SILK FIBROIN BASED NANOPARTICLES

Phạm, Duy Toàn; Saelim, Nuttawut; Tiyaboonchai, Waree · 2018 · International Journal of Applied Pharmaceutics · DOI

Full title: DESIGN OF EXPERIMENTS MODEL FOR THE OPTIMIZATION OF SILK FIBROIN BASED NANOPARTICLES

Authors: Phạm, Duy Toàn; Saelim, Nuttawut; Tiyaboonchai, Waree

Year: 2018

Venue: International Journal of Applied Pharmaceutics

DOI: https://doi.org/10.22159/ijap.2018v10i5.28139

Paper The outline of the expert system for the design of experiment

Dwornicka, Renata; Pietraszek, Jacek · 2018 · Production Engineering Archives · DOI

Full title: The outline of the expert system for the design of experiment

Authors: Dwornicka, Renata; Pietraszek, Jacek

Year: 2018

Venue: Production Engineering Archives

DOI: https://doi.org/10.30657/pea.2018.20.09

Paper Biostoning of textile effluent with laccase enzyme

K. Iqbal; A. Nadeem; U. Zafar · 2021 · Sci. Ind. Res. · DOI

Full title: Biostoning of textile effluent with laccase enzyme

Authors: K. Iqbal; A. Nadeem; U. Zafar

Year: 2021

Venue: Sci. Ind. Res.

DOI: https://doi.org/10.3329/bjsir.v56i2.54318

Paper An Alternative Perfusion Approach for the Intensification of Virus-Like Particle Production in HEK293 Cultures.

Lavado-García, Jesús; Cervera, Laura; Gòdia, Francesc · 2020 · Frontiers in bioengineering and biotechnology · DOI

Full title: An Alternative Perfusion Approach for the Intensification of Virus-Like Particle Production in HEK293 Cultures.

Authors: Lavado-García, Jesús; Cervera, Laura; Gòdia, Francesc

Year: 2020

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2020.00617

Paper One-Time Optimization of Advanced T Cell Culture Media Using a Machine Learning Pipeline.

Grzesik, Paul; Warth, Sebastian C · 2021 · Frontiers in bioengineering and biotechnology · DOI

Full title: One-Time Optimization of Advanced T Cell Culture Media Using a Machine Learning Pipeline.

Authors: Grzesik, Paul; Warth, Sebastian C

Year: 2021

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2021.614324

Paper Modeling and Optimization of Propane Selective Oxidation to Acrylic Acid Over Mo 1 V 0.3 Te 0.23 NB 0.12 O X Catalyst Using Artificial Neural Network and Box-Behnken Design

Golshan Mazloom · 2020 · DOI

Full title: Modeling and Optimization of Propane Selective Oxidation to Acrylic Acid Over Mo 1 V 0.3 Te 0.23 NB 0.12 O X Catalyst Using Artificial Neural Network and Box-Behnken Design

Authors: Golshan Mazloom

Year: 2020

DOI: https://doi.org/10.3329/cerb.v21i1.47368

Paper Biosynthesis of Silver Nanoparticles by Aspergillus terreus: Characterization, Optimization, and Biological Activities.

Lotfy, Walid A; Alkersh, Basma M; Sabry, Soraya A et al. · 2021 · Frontiers in bioengineering and biotechnology · DOI

Full title: Biosynthesis of Silver Nanoparticles by Aspergillus terreus: Characterization, Optimization, and Biological Activities.

Authors: Lotfy, Walid A; Alkersh, Basma M; Sabry, Soraya A; Ghozlan, Hanan A

Year: 2021

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2021.633468

Paper DoE-based medium optimization for improved biosurfactant production with Aureobasidium pullulans.

Haala, Frederick; Dielentheis-Frenken, Marie R E; Brandt, Friedrich M et al. · 2024 · Frontiers in bioengineering and biotechnology · DOI

Full title: DoE-based medium optimization for improved biosurfactant production with Aureobasidium pullulans.

Authors: Haala, Frederick; Dielentheis-Frenken, Marie R E; Brandt, Friedrich M; Karmainski, Tobias; Blank, Lars M; Tiso, Till

Year: 2024

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2024.1379707

Paper Media formulation using statistical methodology to enhance α-amylase production for green synthesis of Au-NPs by Bacillus subtilis VSP4 under solid-state fermentation.

Prajapati, Vimalkumar S; Mehta, Vaibhavkumar N; Patel, Swati K · 2025 · Frontiers in bioengineering and biotechnology · DOI

Full title: Media formulation using statistical methodology to enhance α-amylase production for green synthesis of Au-NPs by Bacillus subtilis VSP4 under solid-state fermentation.

Authors: Prajapati, Vimalkumar S; Mehta, Vaibhavkumar N; Patel, Swati K

Year: 2025

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2025.1569902

Paper Using design of experiments (DoE) to optimize performance and stability of biomimetic cell membrane-coated nanostructures for cancer therapy.

Ferreira, Natália Noronha; Miranda, Renata Rank; Moreno, Natália Sanchez et al. · 2023 · Frontiers in bioengineering and biotechnology · DOI

Full title: Using design of experiments (DoE) to optimize performance and stability of biomimetic cell membrane-coated nanostructures for cancer therapy.

Authors: Ferreira, Natália Noronha; Miranda, Renata Rank; Moreno, Natália Sanchez; Pincela Lins, Paula Maria; Leite, Celisnolia Morais; Leite, Ana Elisa Tognoli; Machado, Thales Rafael; Cataldi, Thaís Regiani; Labate, Carlos Alberto; Reis, Rui Manuel; Zucolotto, Valtencir

Year: 2023

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2023.1120179

Paper Process Characterization by Definitive Screening Design Approach on DNA Vaccine Production.

Hocharoen, Lalintip; Noppiboon, Sarawuth; Kitsubun, Panit · 2020 · Frontiers in bioengineering and biotechnology · DOI

Full title: Process Characterization by Definitive Screening Design Approach on DNA Vaccine Production.

Authors: Hocharoen, Lalintip; Noppiboon, Sarawuth; Kitsubun, Panit

Year: 2020

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2020.574809

Paper Towards the Experimentally-Informed In Silico Nozzle Design Optimization for Extrusion-Based Bioprinting of Shear-Thinning Hydrogels.

Reina-Romo, Esther; Mandal, Sourav; Amorim, Paulo et al. · 2021 · Frontiers in bioengineering and biotechnology · DOI

Full title: Towards the Experimentally-Informed In Silico Nozzle Design Optimization for Extrusion-Based Bioprinting of Shear-Thinning Hydrogels.

Authors: Reina-Romo, Esther; Mandal, Sourav; Amorim, Paulo; Bloemen, Veerle; Ferraris, Eleonora; Geris, Liesbet

Year: 2021

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2021.701778

Paper Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments.

Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald et al. · 2021 · Frontiers in bioengineering and biotechnology · DOI

Full title: Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments.

Authors: Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald; Sissolak, Bernhard

Year: 2021

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2021.740215

Paper Micronutrient optimization for tissue engineered articular cartilage production of type II collagen.

Cruz, Maria A; Gonzalez, Yamilet; Vélez Toro, Javier A et al. · 2023 · Frontiers in bioengineering and biotechnology · DOI

Full title: Micronutrient optimization for tissue engineered articular cartilage production of type II collagen.

Authors: Cruz, Maria A; Gonzalez, Yamilet; Vélez Toro, Javier A; Karimzadeh, Makan; Rubbo, Anthony; Morris, Lauren; Medam, Ramapaada; Splawn, Taylor; Archer, Marilyn; Fernandes, Russell J; Dennis, James E; Kean, Thomas J

Year: 2023

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2023.1179332

Paper Perfusion process with tangential flow filtration for oncolytic VSV-GP production.

Hamusics, Orsolya; Wittmann, Anja; Hasler, Katrin et al. · 2025 · Frontiers in bioengineering and biotechnology · DOI

Full title: Perfusion process with tangential flow filtration for oncolytic VSV-GP production.

Authors: Hamusics, Orsolya; Wittmann, Anja; Hasler, Katrin; Müller, Sabrina; Birk, Daniel; Gorr, Ingo H; Brix, Alexander; Soza-Ried, Jorge

Year: 2025

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2025.1588293

Paper Enabling and improving trans-nerolidol production by Corynebacterium glutamicum: combining metabolic engineering and trace elements medium refinement.

Seeger, Jan; Lohoff, Stella; Schmitfranz, Fabian et al. · 2025 · Frontiers in bioengineering and biotechnology · DOI

Full title: Enabling and improving trans-nerolidol production by Corynebacterium glutamicum: combining metabolic engineering and trace elements medium refinement.

Authors: Seeger, Jan; Lohoff, Stella; Schmitfranz, Fabian; Henke, Nadja A; Wendisch, Volker F

Year: 2025

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2025.1621955

Paper Optimization of Monascus purpureus for Natural Food Pigments Production on Potato Wastes and Their Application in Ice Lolly

Hossam E. F. Abdel-Raheam; S. Alrumman; S. Gadow et al. · 2022 · Frontiers in Microbiology · DOI

Full title: Optimization of Monascus purpureus for Natural Food Pigments Production on Potato Wastes and Their Application in Ice Lolly

Authors: Hossam E. F. Abdel-Raheam; S. Alrumman; S. Gadow; M. El-Sayed; Dalia M. Hikal; A. Hesham; Maysa M. A. Ali

Year: 2022

Venue: Frontiers in Microbiology

DOI: https://doi.org/10.3389/fmicb.2022.862080

Paper High-throughput optimization of antibody production in CHO cells by tuning heavy- and light-chain promoter strength.

Rahimi, Marzia; Adams, Anna Christina; Grav, Lise M et al. · 2025 · Frontiers in bioengineering and biotechnology · DOI

Full title: High-throughput optimization of antibody production in CHO cells by tuning heavy- and light-chain promoter strength.

Authors: Rahimi, Marzia; Adams, Anna Christina; Grav, Lise M; Nielsen, Lars K; Lavado-García, Jesús

Year: 2025

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2025.1747473

Paper Highly Efficient One-Step Protein Immobilization on Polymer Membranes Supported by Response Surface Methodology.

Schmidt, Martin; Abdul Latif, Amira; Prager, Andrea et al. · 2021 · Frontiers in chemistry · DOI

Full title: Highly Efficient One-Step Protein Immobilization on Polymer Membranes Supported by Response Surface Methodology.

Authors: Schmidt, Martin; Abdul Latif, Amira; Prager, Andrea; Gläser, Roger; Schulze, Agnes

Year: 2021

Venue: Frontiers in chemistry

DOI: https://doi.org/10.3389/fchem.2021.804698

Paper Optimizing a Multi-Component Intranasal Entamoeba Histolytica Vaccine Formulation Using a Design of Experiments Strategy.

Abhyankar, Mayuresh M; Orr, Mark T; Kinsey, Robert et al. · 2021 · Frontiers in immunology · DOI

Full title: Optimizing a Multi-Component Intranasal Entamoeba Histolytica Vaccine Formulation Using a Design of Experiments Strategy.

Authors: Abhyankar, Mayuresh M; Orr, Mark T; Kinsey, Robert; Sivananthan, Sandra; Nafziger, Andrew J; Oakland, David N; Young, Mary K; Farr, Laura; Uddin, Md Jashim; Leslie, Jhansi L; Burgess, Stacey L; Liang, Hong; De Lima, Ines; Larson, Elise; Guderian, Jeffrey A; Lin, Susan; Kahn, Aaron; Ghosh, Prakash; Reed, Sierra; Tomai, Mark A; Pedersen, Karl; Petri, William A; Fox, Christopher B

Year: 2021

Venue: Frontiers in immunology

DOI: https://doi.org/10.3389/fimmu.2021.683157

Paper Non-edible Oil Cakes as a Novel Substrate for DPA Production and Augmenting Biocontrol Activity of Paecilomyces variotii.

Arora, Kalpana; Sharma, Satyawati; Krishna, Suresh B N et al. · 2017 · Frontiers in microbiology · DOI

Full title: Non-edible Oil Cakes as a Novel Substrate for DPA Production and Augmenting Biocontrol Activity of Paecilomyces variotii.

Authors: Arora, Kalpana; Sharma, Satyawati; Krishna, Suresh B N; Adam, Jamila K; Kumar, Ashwani

Year: 2017

Venue: Frontiers in microbiology

DOI: https://doi.org/10.3389/fmicb.2017.00753

Paper Optimizing microwave-assisted extraction of ursolic acid from apple pomace using response surface methodology

Xiyun Sun; Wenjian Zhang; Xianjun Meng et al. · 2025 · Frontiers in Nutrition · DOI

Full title: Optimizing microwave-assisted extraction of ursolic acid from apple pomace using response surface methodology

Authors: Xiyun Sun; Wenjian Zhang; Xianjun Meng; Sajad Shokri

Year: 2025

Venue: Frontiers in Nutrition

DOI: https://doi.org/10.3389/fnut.2025.1604863

Paper Chromatography Conditions Development by Design of Experiments for the Chemotype Differentiation of Four Bauhinia Species.

Aquino, Amanda J; Pereira-Filho, Edenir R; Oliveira, Regina V et al. · 2022 · Frontiers in chemistry · DOI

Full title: Chromatography Conditions Development by Design of Experiments for the Chemotype Differentiation of Four Bauhinia Species.

Authors: Aquino, Amanda J; Pereira-Filho, Edenir R; Oliveira, Regina V; Cass, Quezia B

Year: 2022

Venue: Frontiers in chemistry

DOI: https://doi.org/10.3389/fchem.2022.800729

Paper Characterization of saltern based Streptomyces sp. and statistical media optimization for its improved antibacterial activity.

Rajeswari, Pandiyan; Jose, Polpass Arul; Amiya, Richa et al. · 2014 · Frontiers in microbiology · DOI

Full title: Characterization of saltern based Streptomyces sp. and statistical media optimization for its improved antibacterial activity.

Authors: Rajeswari, Pandiyan; Jose, Polpass Arul; Amiya, Richa; Jebakumar, Solomon Robinson David

Year: 2014

Venue: Frontiers in microbiology

DOI: https://doi.org/10.3389/fmicb.2014.00753

Paper 3D culture of neural progenitor cells in gelatin norbornene (GelNB) hydrogels: mechanical tuning and hypoxia characterization.

Dienemann, Sandra; Wohlenberg, Ole Jacob; Gerstenberger, Jan Georg et al. · 2025 · Frontiers in bioengineering and biotechnology · DOI

Full title: 3D culture of neural progenitor cells in gelatin norbornene (GelNB) hydrogels: mechanical tuning and hypoxia characterization.

Authors: Dienemann, Sandra; Wohlenberg, Ole Jacob; Gerstenberger, Jan Georg; Lavrentieva, Antonina; Pepelanova, Iliyana

Year: 2025

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2025.1579580

Paper Exploring the Potential of Lactic Acid Fermentation for the Recovery of Exhausted Vanilla Beans.

Hadj Saadoun, Jasmine; Levante, Alessia; Ferrillo, Antonio et al. · 2022 · Frontiers in nutrition · DOI

Full title: Exploring the Potential of Lactic Acid Fermentation for the Recovery of Exhausted Vanilla Beans.

Authors: Hadj Saadoun, Jasmine; Levante, Alessia; Ferrillo, Antonio; Trapani, Francesca; Bernini, Valentina; Galaverna, Gianni; Neviani, Erasmo; Lazzi, Camilla

Year: 2022

Venue: Frontiers in nutrition

DOI: https://doi.org/10.3389/fnut.2022.858716

Paper Comprehensive Exploration of the Growth and Lipid Synthesis Phases of T. oleaginosus Cultures Implementing Design of Experiments and Response Surface Methodology.

Parisis, Vasileios; Tsave, Olga; Papanikolaou, Christina et al. · 2023 · Bioengineering (Basel, Switzerland) · DOI

Full title: Comprehensive Exploration of the Growth and Lipid Synthesis Phases of T. oleaginosus Cultures Implementing Design of Experiments and Response Surface Methodology.

Authors: Parisis, Vasileios; Tsave, Olga; Papanikolaou, Christina; Pantazopoulou, Erasmia; Chatzidoukas, Christos

Year: 2023

Venue: Bioengineering (Basel, Switzerland)

DOI: https://doi.org/10.3390/bioengineering10121359

Paper New Features on the Environmental Regulation of Metabolism Revealed by Modeling the Cellular Proteomic Adaptations Induced by Light, Carbon, and Inorganic Nitrogen in Chlamydomonas reinhardtii.

Gérin, Stéphanie; Leprince, Pierre; Sluse, Francis E et al. · 2016 · Frontiers in plant science · DOI

Full title: New Features on the Environmental Regulation of Metabolism Revealed by Modeling the Cellular Proteomic Adaptations Induced by Light, Carbon, and Inorganic Nitrogen in Chlamydomonas reinhardtii.

Authors: Gérin, Stéphanie; Leprince, Pierre; Sluse, Francis E; Franck, Fabrice; Mathy, Grégory

Year: 2016

Venue: Frontiers in plant science

DOI: https://doi.org/10.3389/fpls.2016.01158

Paper Investigation of Cellular Interactions of Lipid-Structured Nanoparticles With Oral Mucosal Epithelial Cells.

Jeitler, R; Glader, C; Tetyczka, C et al. · 2022 · Frontiers in molecular biosciences · DOI

Full title: Investigation of Cellular Interactions of Lipid-Structured Nanoparticles With Oral Mucosal Epithelial Cells.

Authors: Jeitler, R; Glader, C; Tetyczka, C; Zeiringer, S; Absenger-Novak, M; Selmani, A; Fröhlich, E; Roblegg, E

Year: 2022

Venue: Frontiers in molecular biosciences

DOI: https://doi.org/10.3389/fmolb.2022.917921

Paper Modeling and Optimizing Culture Medium Mineral Composition for in vitro Propagation of Actinidia arguta.

Hameg, Radhia; Arteta, Tomás A; Landin, Mariana et al. · 2020 · Frontiers in plant science · DOI

Full title: Modeling and Optimizing Culture Medium Mineral Composition for in vitro Propagation of Actinidia arguta.

Authors: Hameg, Radhia; Arteta, Tomás A; Landin, Mariana; Gallego, Pedro P; Barreal, M Esther

Year: 2020

Venue: Frontiers in plant science

DOI: https://doi.org/10.3389/fpls.2020.554905

Paper Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties.

Tanase, Corneliu; Mocan, Andrei; Coșarcă, Sanda et al. · 2019 · Antioxidants (Basel, Switzerland) · DOI

Full title: Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties.

Authors: Tanase, Corneliu; Mocan, Andrei; Coșarcă, Sanda; Gavan, Alexandru; Nicolescu, Alexandru; Gheldiu, Ana-Maria; Vodnar, Dan C; Muntean, Daniela-Lucia; Crișan, Ovidiu

Year: 2019

Venue: Antioxidants (Basel, Switzerland)

DOI: https://doi.org/10.3390/antiox8090417

Paper Combining DOE With Neurofuzzy Logic for Healthy Mineral Nutrition of Pistachio Rootstocks in vitro Culture.

Nezami-Alanagh, Esmaeil; Garoosi, Ghasem-Ali; Landín, Mariana et al. · 2018 · Frontiers in plant science · DOI

Full title: Combining DOE With Neurofuzzy Logic for Healthy Mineral Nutrition of Pistachio Rootstocks in vitro Culture.

Authors: Nezami-Alanagh, Esmaeil; Garoosi, Ghasem-Ali; Landín, Mariana; Gallego, Pedro Pablo

Year: 2018

Venue: Frontiers in plant science

DOI: https://doi.org/10.3389/fpls.2018.01474

Paper Exploiting the Potential of Bioactive Molecules Extracted by Ultrasounds from Avocado Peels—Food and Nutraceutical Applications

Beatriz Rodríguez-Martínez; P. Ferreira-Santos; B. Gullón et al. · 2021 · Antioxidants · DOI

Full title: Exploiting the Potential of Bioactive Molecules Extracted by Ultrasounds from Avocado Peels—Food and Nutraceutical Applications

Authors: Beatriz Rodríguez-Martínez; P. Ferreira-Santos; B. Gullón; J. Teixeira; C. Botelho; R. Yáñez

Year: 2021

Venue: Antioxidants

DOI: https://doi.org/10.3390/antiox10091475

Paper An Integrated Downstream Process Development Strategy along QbD Principles.

Meitz, Andrea; Sagmeister, Patrick; Langemann, Timo et al. · 2014 · Bioengineering (Basel, Switzerland) · DOI

Full title: An Integrated Downstream Process Development Strategy along QbD Principles.

Authors: Meitz, Andrea; Sagmeister, Patrick; Langemann, Timo; Herwig, Christoph

Year: 2014

Venue: Bioengineering (Basel, Switzerland)

DOI: https://doi.org/10.3390/bioengineering1040213

Paper Optimization of High-Temperature CO2 Capture by Lithium Orthosilicate-Based Sorbents Using Response Surface Methodology

Eleonora Stefanelli; Flavio Francalanci; S. Vitolo et al. · 2024 · Atmosphere · DOI

Full title: Optimization of High-Temperature CO2 Capture by Lithium Orthosilicate-Based Sorbents Using Response Surface Methodology

Authors: Eleonora Stefanelli; Flavio Francalanci; S. Vitolo; Monica Puccini

Year: 2024

Venue: Atmosphere

DOI: https://doi.org/10.3390/atmos15080908

Paper Effect of Zinc-Calcium on Xylose Consumption by Mucor circinelloides (MN128960): Xylitol and Ethanol Yield Optimization

Hector M. Fonseca-Peralta; Karen V. Pineda-Hidalgo; C. Castro-Martínez et al. · 2022 · Energies · DOI

Full title: Effect of Zinc-Calcium on Xylose Consumption by Mucor circinelloides (MN128960): Xylitol and Ethanol Yield Optimization

Authors: Hector M. Fonseca-Peralta; Karen V. Pineda-Hidalgo; C. Castro-Martínez; I. Contreras-Andrade

Year: 2022

Venue: Energies

DOI: https://doi.org/10.3390/en15030906

Paper Seed Train Optimization in Microcarrier-Based Cell Culture Post In Situ Cell Detachment through Scale-Down Hybrid Modeling.

Ebrahimian, Atefeh; Schalk, Mona; Dürkop, Mark et al. · 2024 · Bioengineering (Basel, Switzerland) · DOI

Full title: Seed Train Optimization in Microcarrier-Based Cell Culture Post In Situ Cell Detachment through Scale-Down Hybrid Modeling.

Authors: Ebrahimian, Atefeh; Schalk, Mona; Dürkop, Mark; Maurer, Michael; Bliem, Rudolf; Kühnel, Harald

Year: 2024

Venue: Bioengineering (Basel, Switzerland)

DOI: https://doi.org/10.3390/bioengineering11030268

Paper Computer-Based Tools Unmask Critical Mineral Nutrient Interactions in Hoagland Solution for Healthy Kiwiberry Plant Acclimatization.

Maleki, Sara; Maleki Zanjani, Bahram; Kohnehrouz, Bahram Baghban et al. · 2021 · Frontiers in plant science · DOI

Full title: Computer-Based Tools Unmask Critical Mineral Nutrient Interactions in Hoagland Solution for Healthy Kiwiberry Plant Acclimatization.

Authors: Maleki, Sara; Maleki Zanjani, Bahram; Kohnehrouz, Bahram Baghban; Landin, Mariana; Gallego, Pedro Pablo

Year: 2021

Venue: Frontiers in plant science

DOI: https://doi.org/10.3389/fpls.2021.723992

Paper Lifecycle DoE-The Companion for a Holistic Development Process.

Kunzelmann, Marco; Wittmann, Anja; Presser, Beate et al. · 2024 · Bioengineering (Basel, Switzerland) · DOI

Full title: Lifecycle DoE-The Companion for a Holistic Development Process.

Authors: Kunzelmann, Marco; Wittmann, Anja; Presser, Beate; Brosig, Philipp; Marhoffer, Pia Kristin; Haider, Marlene Antje; Martin, Julia; Berger, Martina; Wucherpfennig, Thomas

Year: 2024

Venue: Bioengineering (Basel, Switzerland)

DOI: https://doi.org/10.3390/bioengineering11111089

Paper Sustainable Endoglucanase Production from Lignocellulosic Waste Through Fungal Co-Culture Technology: A Step Towards Circular Economy.

Ali, Imran; Butt, Hira; Abdullah, Roheena et al. · 2026 · Biology · DOI

Full title: Sustainable Endoglucanase Production from Lignocellulosic Waste Through Fungal Co-Culture Technology: A Step Towards Circular Economy.

Authors: Ali, Imran; Butt, Hira; Abdullah, Roheena; Kaleem, Afshan; Aftab, Mahwish; Iqtedar, Mehwish; Iqbal, Irfana; Chen, Xiaoming

Year: 2026

Venue: Biology

DOI: https://doi.org/10.3390/biology15050399

Paper Holistic Design of Experiments Using an Integrated Process Model.

Oberleitner, Thomas; Zahel, Thomas; Pretzner, Barbara et al. · 2022 · Bioengineering (Basel, Switzerland) · DOI

Full title: Holistic Design of Experiments Using an Integrated Process Model.

Authors: Oberleitner, Thomas; Zahel, Thomas; Pretzner, Barbara; Herwig, Christoph

Year: 2022

Venue: Bioengineering (Basel, Switzerland)

DOI: https://doi.org/10.3390/bioengineering9110643

Paper Finite Element Analysis of a Rib Cage Model: Influence of Four Variables on Fatigue Life during Simulated Manual CPR.

Jeon, Jong Hyeok; Sul, Jae Ho; Ko, Dae Hwan et al. · 2024 · Bioengineering (Basel, Switzerland) · DOI

Full title: Finite Element Analysis of a Rib Cage Model: Influence of Four Variables on Fatigue Life during Simulated Manual CPR.

Authors: Jeon, Jong Hyeok; Sul, Jae Ho; Ko, Dae Hwan; Seo, Myoung Jae; Kim, Sung Min; Lim, Hong Seok

Year: 2024

Venue: Bioengineering (Basel, Switzerland)

DOI: https://doi.org/10.3390/bioengineering11050491

Paper Defining a Simplified Process in Yeast for Production of Enveloped VLP Dengue Vaccine.

de Sá Magalhães, Salomé; Morris, Stephen A; Kusumawardani, Shinta et al. · 2025 · Bioengineering (Basel, Switzerland) · DOI

Full title: Defining a Simplified Process in Yeast for Production of Enveloped VLP Dengue Vaccine.

Authors: de Sá Magalhães, Salomé; Morris, Stephen A; Kusumawardani, Shinta; Wijayadikusumah, Acep Riza; Nurainy, Neni; Keshavarz-Moore, Eli

Year: 2025

Venue: Bioengineering (Basel, Switzerland)

DOI: https://doi.org/10.3390/bioengineering12090956

Paper The Goldilocks Approach: A Review of Employing Design of Experiments in Prokaryotic Recombinant Protein Production.

Uhoraningoga, Albert; Kinsella, Gemma K; Henehan, Gary T et al. · 2018 · Bioengineering (Basel, Switzerland) · DOI

Full title: The Goldilocks Approach: A Review of Employing Design of Experiments in Prokaryotic Recombinant Protein Production.

Authors: Uhoraningoga, Albert; Kinsella, Gemma K; Henehan, Gary T; Ryan, Barry J

Year: 2018

Venue: Bioengineering (Basel, Switzerland)

DOI: https://doi.org/10.3390/bioengineering5040089

Paper A Design of Experiments Approach for Enhancing Room Temperature Stability of a Lyophilised and Paper-Based Bacterial Cell-Free System.

Shivakumar, Tejasvi; Clark, Joshua; Goode, Alice et al. · 2025 · Bioengineering (Basel, Switzerland) · DOI

Full title: A Design of Experiments Approach for Enhancing Room Temperature Stability of a Lyophilised and Paper-Based Bacterial Cell-Free System.

Authors: Shivakumar, Tejasvi; Clark, Joshua; Goode, Alice; Anyanwu, Valentine E; Williams, Philip M

Year: 2025

Venue: Bioengineering (Basel, Switzerland)

DOI: https://doi.org/10.3390/bioengineering12030223

Paper Maximization of the Minicircle DNA Vaccine Production Expressing SARS-CoV-2 RBD.

Ventura, Cathy; Eusébio, Dalinda; Gonçalves, Ana M et al. · 2022 · Biomedicines · DOI

Full title: Maximization of the Minicircle DNA Vaccine Production Expressing SARS-CoV-2 RBD.

Authors: Ventura, Cathy; Eusébio, Dalinda; Gonçalves, Ana M; Barroca-Ferreira, Jorge; Costa, Diana; Cui, Zhengrong; Passarinha, Luís A; Sousa, Ângela

Year: 2022

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines10050990

Paper The Statistical Optimisation of Recombinant β-glucosidase Production through a Two-Stage, Multi-Model, Design of Experiments Approach.

Uhoraningoga, Albert; Kinsella, Gemma K; Frias, Jesus M et al. · 2019 · Bioengineering (Basel, Switzerland) · DOI

Full title: The Statistical Optimisation of Recombinant β-glucosidase Production through a Two-Stage, Multi-Model, Design of Experiments Approach.

Authors: Uhoraningoga, Albert; Kinsella, Gemma K; Frias, Jesus M; Henehan, Gary T; Ryan, Barry J

Year: 2019

Venue: Bioengineering (Basel, Switzerland)

DOI: https://doi.org/10.3390/bioengineering6030061

Paper Bayesian Optimization Based on K-Optimality.

Yan, Liang; Duan, Xiaojun; Liu, Bowen et al. · 2018 · Entropy (Basel, Switzerland) · DOI

Full title: Bayesian Optimization Based on K-Optimality.

Authors: Yan, Liang; Duan, Xiaojun; Liu, Bowen; Xu, Jin

Year: 2018

Venue: Entropy (Basel, Switzerland)

DOI: https://doi.org/10.3390/e20080594

Paper A Design of Experiments Strategy to Enhance the Recovery of Polyphenolic Compounds from Vitis vinifera By-Products through Heat Reflux Extraction.

Moldovan, Mirela L; Iurian, Sonia; Puscas, Cristina et al. · 2019 · Biomolecules · DOI

Full title: A Design of Experiments Strategy to Enhance the Recovery of Polyphenolic Compounds from Vitis vinifera By-Products through Heat Reflux Extraction.

Authors: Moldovan, Mirela L; Iurian, Sonia; Puscas, Cristina; Silaghi-Dumitrescu, Radu; Hanganu, Daniela; Bogdan, Catalina; Vlase, Laurian; Oniga, Ilioara; Benedec, Daniela

Year: 2019

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom9100529

Paper Design of Experiments: Useful Orthogonal Arrays for Number of Experiments from 4 to 16

Bolboacă, Sorana D.; Jäntschi, Lorentz · 2007 · Entropy · DOI

Full title: Design of Experiments: Useful Orthogonal Arrays for Number of Experiments from 4 to 16

Authors: Bolboacă, Sorana D.; Jäntschi, Lorentz

Year: 2007

Venue: Entropy

DOI: https://doi.org/10.3390/e9040198

Paper Quality by Design (QbD) and Design of Experiments (DOE) as a Strategy for Tuning Lipid Nanoparticle Formulations for RNA Delivery.

Gurba-Bryśkiewicz, Lidia; Maruszak, Wioleta; Smuga, Damian A et al. · 2023 · Biomedicines · DOI

Full title: Quality by Design (QbD) and Design of Experiments (DOE) as a Strategy for Tuning Lipid Nanoparticle Formulations for RNA Delivery.

Authors: Gurba-Bryśkiewicz, Lidia; Maruszak, Wioleta; Smuga, Damian A; Dubiel, Krzysztof; Wieczorek, Maciej

Year: 2023

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines11102752

Paper Optimizing Soluble Cues for Salivary Gland Tissue Mimetics Using a Design of Experiments (DoE) Approach.

Piraino, Lindsay R; Benoit, Danielle S W; DeLouise, Lisa A · 2022 · Cells · DOI

Full title: Optimizing Soluble Cues for Salivary Gland Tissue Mimetics Using a Design of Experiments (DoE) Approach.

Authors: Piraino, Lindsay R; Benoit, Danielle S W; DeLouise, Lisa A

Year: 2022

Venue: Cells

DOI: https://doi.org/10.3390/cells11121962

Paper Phytochemicals Recovery from Grape Pomace: Extraction Improvement and Chemometric Study.

Ferri, Maura; Lima, Vasco; Zappi, Alessandro et al. · 2023 · Foods (Basel, Switzerland) · DOI

Full title: Phytochemicals Recovery from Grape Pomace: Extraction Improvement and Chemometric Study.

Authors: Ferri, Maura; Lima, Vasco; Zappi, Alessandro; Fernando, Ana Luísa; Melucci, Dora; Tassoni, Annalisa

Year: 2023

Venue: Foods (Basel, Switzerland)

DOI: https://doi.org/10.3390/foods12050959

Paper Chemical Composition, Fatty Acid Profile, and Optimization of the Sacha Inchi (Plukenetia volubilis L.) Seed-Roasting Process Using Response Surface Methodology: Assessment of Oxidative Stability and Antioxidant Activity

Nelsy Bocanegra Morales; Paula Galeano García · 2023 · Foods · DOI

Full title: Chemical Composition, Fatty Acid Profile, and Optimization of the Sacha Inchi (Plukenetia volubilis L.) Seed-Roasting Process Using Response Surface Methodology: Assessment of Oxidative Stability and Antioxidant Activity

Authors: Nelsy Bocanegra Morales; Paula Galeano García

Year: 2023

Venue: Foods

DOI: https://doi.org/10.3390/foods12183405

Paper Supercritical Carbon Dioxide in Presence of Water for the Valorization of Spent Coffee Grounds: Optimization by Response Surface Methodology and Investigation of Caffeine Extraction Mechanism.

Vandeponseele, Alexandre; Draye, Micheline; Piot, Christine et al. · 2022 · Foods (Basel, Switzerland) · DOI

Full title: Supercritical Carbon Dioxide in Presence of Water for the Valorization of Spent Coffee Grounds: Optimization by Response Surface Methodology and Investigation of Caffeine Extraction Mechanism.

Authors: Vandeponseele, Alexandre; Draye, Micheline; Piot, Christine; Bernard, Damien; Fanget, Philippe; Chatel, Gregory

Year: 2022

Venue: Foods (Basel, Switzerland)

DOI: https://doi.org/10.3390/foods11244089

Paper Optimization of cis-9-Heptadecenoic Acid Production from the Oleaginous Yeast Yarrowia lipolytica

Wendy Al Sahyouni; Sally El Kantar; A. Khelfa et al. · 2022 · Fermentation · DOI

Full title: Optimization of cis-9-Heptadecenoic Acid Production from the Oleaginous Yeast Yarrowia lipolytica

Authors: Wendy Al Sahyouni; Sally El Kantar; A. Khelfa; Young-Kyoung Park; J. Nicaud; N. Louka; M. Koubaa

Year: 2022

Venue: Fermentation

DOI: https://doi.org/10.3390/fermentation8060245

Paper Exploring the Bioactive Potential of Gracilaria gracilis: An Extraction Optimization Study Using Response Surface Methodology

C. Neves; S. Morais; T. Vale et al. · 2023 · Foods · DOI

Full title: Exploring the Bioactive Potential of Gracilaria gracilis: An Extraction Optimization Study Using Response Surface Methodology

Authors: C. Neves; S. Morais; T. Vale; Cristina Soares; Clara Grosso; V. Domingues; Mónica Vieira; C. Delerue-Matos

Year: 2023

Venue: Foods

DOI: https://doi.org/10.3390/foods2023-15026

Paper Clever Experimental Designs: Shortcuts for Better iPSC Differentiation.

Yasui, Ryota; Sekine, Keisuke; Taniguchi, Hideki · 2021 · Cells · DOI

Full title: Clever Experimental Designs: Shortcuts for Better iPSC Differentiation.

Authors: Yasui, Ryota; Sekine, Keisuke; Taniguchi, Hideki

Year: 2021

Venue: Cells

DOI: https://doi.org/10.3390/cells10123540

Paper Optimization of Protein Extraction of Oenological Interest from Grape Seed Meal Using Design of Experiments and Response Surface Methodology.

Baca-Bocanegra, Berta; Nogales-Bueno, Julio; Hernández-Hierro, José Miguel et al. · 2021 · Foods (Basel, Switzerland) · DOI

Full title: Optimization of Protein Extraction of Oenological Interest from Grape Seed Meal Using Design of Experiments and Response Surface Methodology.

Authors: Baca-Bocanegra, Berta; Nogales-Bueno, Julio; Hernández-Hierro, José Miguel; Heredia, Francisco José

Year: 2021

Venue: Foods (Basel, Switzerland)

DOI: https://doi.org/10.3390/foods10010079

Paper The Role of Machine Learning and Design of Experiments in the Advancement of Biomaterial and Tissue Engineering Research.

Al-Kharusi, Ghayadah; Dunne, Nicholas J; Little, Suzanne et al. · 2022 · Bioengineering (Basel, Switzerland) · DOI

Full title: The Role of Machine Learning and Design of Experiments in the Advancement of Biomaterial and Tissue Engineering Research.

Authors: Al-Kharusi, Ghayadah; Dunne, Nicholas J; Little, Suzanne; Levingstone, Tanya J

Year: 2022

Venue: Bioengineering (Basel, Switzerland)

DOI: https://doi.org/10.3390/bioengineering9100561

Paper Production of Trans-Cinnamic Acid by Immobilization of the Bambusa oldhamii BoPAL1 and BoPAL2 Phenylalanine Ammonia-Lyases on Electrospun Nanofibers

Pei-Yu Hong; Yi-Hao Huang; G. W. Lim et al. · 2021 · International Journal of Molecular Sciences · DOI

Full title: Production of Trans-Cinnamic Acid by Immobilization of the Bambusa oldhamii BoPAL1 and BoPAL2 Phenylalanine Ammonia-Lyases on Electrospun Nanofibers

Authors: Pei-Yu Hong; Yi-Hao Huang; G. W. Lim; Yen-Po Chen; C. Hsiao; Li-Hsien Chen; Jhih‐Ying Ciou; L. Hsieh

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms222011184

Paper Optimization of Xylanase production from Penicillium sp.WX-Z1 by a two-step statistical strategy: Plackett-Burman and Box-Behnken experimental design.

Cui, Fengjie; Zhao, Liming · 2012 · International journal of molecular sciences · DOI

Full title: Optimization of Xylanase production from Penicillium sp.WX-Z1 by a two-step statistical strategy: Plackett-Burman and Box-Behnken experimental design.

Authors: Cui, Fengjie; Zhao, Liming

Year: 2012

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms130810630

Paper Optimization of ligninolytic enzyme activity and production rate with Ceriporiopsis subvermispora for application in bioremediation by varying submerged media composition and growth immobilization support.

Babič, Janja; Likozar, Blaž; Pavko, Aleksander · 2012 · International journal of molecular sciences · DOI

Full title: Optimization of ligninolytic enzyme activity and production rate with Ceriporiopsis subvermispora for application in bioremediation by varying submerged media composition and growth immobilization support.

Authors: Babič, Janja; Likozar, Blaž; Pavko, Aleksander

Year: 2012

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms130911365

Paper Use of Food Spoilage and Safety Predictor for an "A Priori" Modeling of the Growth of Lactic Acid Bacteria in Fermented Smoked Fish Products.

Racioppo, Angela; Campaniello, Daniela; Sinigaglia, Milena et al. · 2022 · Foods (Basel, Switzerland) · DOI

Full title: Use of Food Spoilage and Safety Predictor for an "A Priori" Modeling of the Growth of Lactic Acid Bacteria in Fermented Smoked Fish Products.

Authors: Racioppo, Angela; Campaniello, Daniela; Sinigaglia, Milena; Bevilacqua, Antonio; Speranza, Barbara; Corbo, Maria Rosaria

Year: 2022

Venue: Foods (Basel, Switzerland)

DOI: https://doi.org/10.3390/foods11070946

Paper Production of Polyhydroxyalkanoates through Soybean Hull and Waste Glycerol Valorization: Subsequent Alkaline Pretreatment and Enzymatic Hydrolysis

Zulma Sarmiento-Vásquez; L. Vandenberghe; S. Karp et al. · 2022 · Fermentation · DOI

Full title: Production of Polyhydroxyalkanoates through Soybean Hull and Waste Glycerol Valorization: Subsequent Alkaline Pretreatment and Enzymatic Hydrolysis

Authors: Zulma Sarmiento-Vásquez; L. Vandenberghe; S. Karp; C. Soccol

Year: 2022

Venue: Fermentation

DOI: https://doi.org/10.3390/fermentation8090433

Paper Optimization of Polyplex Formation between DNA Oligonucleotide and Poly(ʟ-Lysine): Experimental Study and Modeling Approach.

Vasiliu, Tudor; Cojocaru, Corneliu; Rotaru, Alexandru et al. · 2017 · International journal of molecular sciences · DOI

Full title: Optimization of Polyplex Formation between DNA Oligonucleotide and Poly(ʟ-Lysine): Experimental Study and Modeling Approach.

Authors: Vasiliu, Tudor; Cojocaru, Corneliu; Rotaru, Alexandru; Pricope, Gabriela; Pinteala, Mariana; Clima, Lilia

Year: 2017

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms18061291

Paper Optimization and Validation of an Ultra-Performance Liquid Chromatography with Quadrupole Detector Mass Spectrometry Quantification Method for the Simultaneous Detection of Tazarotene and Tazarotenic Acid in Porcine Skin: An In Vitro Study.

Hamzehpour, Helena; Hauksson, Kristófer H; Jónsson, Helgi et al. · 2025 · International journal of molecular sciences · DOI

Full title: Optimization and Validation of an Ultra-Performance Liquid Chromatography with Quadrupole Detector Mass Spectrometry Quantification Method for the Simultaneous Detection of Tazarotene and Tazarotenic Acid in Porcine Skin: An In Vitro Study.

Authors: Hamzehpour, Helena; Hauksson, Kristófer H; Jónsson, Helgi; Gizurarson, Sveinbjorn; Snorradottir, Bergthora S

Year: 2025

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms26020489

Paper Biocatalyzed Synthesis of Flavor Esters and Polyesters: A Design of Experiments (DoE) Approach.

Fabbri, Filippo; Bertolini, Federico A; Guebitz, Georg M et al. · 2021 · International journal of molecular sciences · DOI

Full title: Biocatalyzed Synthesis of Flavor Esters and Polyesters: A Design of Experiments (DoE) Approach.

Authors: Fabbri, Filippo; Bertolini, Federico A; Guebitz, Georg M; Pellis, Alessandro

Year: 2021

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms22168493

Paper Alginate-Gelatin Hydrogel Scaffolds; An Optimization of Post-Printing Treatment for Enhanced Degradation and Swelling Behavior.

Kaliampakou, Christina; Lagopati, Nefeli; Pavlatou, Evangelia A et al. · 2023 · Gels (Basel, Switzerland) · DOI

Full title: Alginate-Gelatin Hydrogel Scaffolds; An Optimization of Post-Printing Treatment for Enhanced Degradation and Swelling Behavior.

Authors: Kaliampakou, Christina; Lagopati, Nefeli; Pavlatou, Evangelia A; Charitidis, Costas A

Year: 2023

Venue: Gels (Basel, Switzerland)

DOI: https://doi.org/10.3390/gels9110857

Paper Development of In Vitro Dry Eye Models to Study Proliferative and Anti-Inflammatory Effects of Allogeneic Serum Eye Drops.

Voß, Silja; Behrmann, Till; Reichl, Stephan · 2023 · International journal of molecular sciences · DOI

Full title: Development of In Vitro Dry Eye Models to Study Proliferative and Anti-Inflammatory Effects of Allogeneic Serum Eye Drops.

Authors: Voß, Silja; Behrmann, Till; Reichl, Stephan

Year: 2023

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms24021567

Paper RSM Optimization for the Recovery of Technofunctional Protein Extracts from Porcine Hearts

D. Parés; M. Toldrà; E. Camps et al. · 2020 · Foods · DOI

Full title: RSM Optimization for the Recovery of Technofunctional Protein Extracts from Porcine Hearts

Authors: D. Parés; M. Toldrà; E. Camps; Juan Geli; E. Saguer; C. Carretero

Year: 2020

Venue: Foods

DOI: https://doi.org/10.3390/foods9121733

Paper Computer Optimization of Biodegradable Nanoparticles Fabricated by Dispersion Polymerization.

Akala, Emmanuel O; Adesina, Simeon; Ogunwuyi, Oluwaseun · 2015 · International journal of environmental research and public health · DOI

Full title: Computer Optimization of Biodegradable Nanoparticles Fabricated by Dispersion Polymerization.

Authors: Akala, Emmanuel O; Adesina, Simeon; Ogunwuyi, Oluwaseun

Year: 2015

Venue: International journal of environmental research and public health

DOI: https://doi.org/10.3390/ijerph13010047

Paper Optimization of Film-Dressings Containing Herbal Extracts for Wound Care-A Quality by Design Approach.

Safta, Diana Antonia; Bogdan, Cătălina; Iurian, Sonia et al. · 2025 · Gels (Basel, Switzerland) · DOI

Full title: Optimization of Film-Dressings Containing Herbal Extracts for Wound Care-A Quality by Design Approach.

Authors: Safta, Diana Antonia; Bogdan, Cătălina; Iurian, Sonia; Moldovan, Mirela-Liliana

Year: 2025

Venue: Gels (Basel, Switzerland)

DOI: https://doi.org/10.3390/gels11050322

Paper A Novel Approach to Optimize Hot Melt Impregnation in Terms of Amorphization Efficiency.

Garbera, Kamil; Ciura, Krzesimir; Sawicki, Wiesław · 2020 · International journal of molecular sciences · DOI

Full title: A Novel Approach to Optimize Hot Melt Impregnation in Terms of Amorphization Efficiency.

Authors: Garbera, Kamil; Ciura, Krzesimir; Sawicki, Wiesław

Year: 2020

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms21114032

Paper Optimization Workflow of Fumonisin Esterase Production for Biocatalytic Degradation of Fumonisin B1.

Incze, Dániel János; Poppe, László; Bata, Zsófia · 2023 · Life (Basel, Switzerland) · DOI

Full title: Optimization Workflow of Fumonisin Esterase Production for Biocatalytic Degradation of Fumonisin B1.

Authors: Incze, Dániel János; Poppe, László; Bata, Zsófia

Year: 2023

Venue: Life (Basel, Switzerland)

DOI: https://doi.org/10.3390/life13091885

Paper Optimization of Bromelain-Aided Production of Angiotensin I-Converting Enzyme Inhibitory Hydrolysates from Stone Fish Using Response Surface Methodology.

Muhammad Auwal, Shehu; Zarei, Mohammad; Abdul-Hamid, Azizah et al. · 2017 · Marine drugs · DOI

Full title: Optimization of Bromelain-Aided Production of Angiotensin I-Converting Enzyme Inhibitory Hydrolysates from Stone Fish Using Response Surface Methodology.

Authors: Muhammad Auwal, Shehu; Zarei, Mohammad; Abdul-Hamid, Azizah; Saari, Nazamid

Year: 2017

Venue: Marine drugs

DOI: https://doi.org/10.3390/md15040104

Paper Suitability of Gelatin Methacrylate and Hydroxyapatite Hydrogels for 3D-Bioprinted Bone Tissue.

Stolarov, Paul; de Vries, Jonathan; Stapleton, Sean et al. · 2024 · Materials (Basel, Switzerland) · DOI

Full title: Suitability of Gelatin Methacrylate and Hydroxyapatite Hydrogels for 3D-Bioprinted Bone Tissue.

Authors: Stolarov, Paul; de Vries, Jonathan; Stapleton, Sean; Morris, Lauren; Martyniak, Kari; Kean, Thomas J

Year: 2024

Venue: Materials (Basel, Switzerland)

DOI: https://doi.org/10.3390/ma17051218

Paper Surface Response Based Modeling of Liposome Characteristics in a Periodic Disturbance Mixer.

López, Rubén R; Ocampo, Ixchel; Sánchez, Luz-María et al. · 2020 · Micromachines · DOI

Full title: Surface Response Based Modeling of Liposome Characteristics in a Periodic Disturbance Mixer.

Authors: López, Rubén R; Ocampo, Ixchel; Sánchez, Luz-María; Alazzam, Anas; Bergeron, Karl-F; Camacho-León, Sergio; Mounier, Catherine; Stiharu, Ion; Nerguizian, Vahé

Year: 2020

Venue: Micromachines

DOI: https://doi.org/10.3390/mi11030235

Paper Towards a Material-by-Design Approach to Electrospun Scaffolds for Tissue Engineering Based on Statistical Design of Experiments (DOE).

Carotenuto, Felicia; Fiaschini, Noemi; Di Nardo, Paolo et al. · 2023 · Materials (Basel, Switzerland) · DOI

Full title: Towards a Material-by-Design Approach to Electrospun Scaffolds for Tissue Engineering Based on Statistical Design of Experiments (DOE).

Authors: Carotenuto, Felicia; Fiaschini, Noemi; Di Nardo, Paolo; Rinaldi, Antonio

Year: 2023

Venue: Materials (Basel, Switzerland)

DOI: https://doi.org/10.3390/ma16041539

Paper Improved Itaconate Production with Ustilago cynodontis via Co-Metabolism of CO2-Derived Formate.

Ullmann, Lena; Guntermann, Nils; Kohl, Philipp et al. · 2022 · Journal of fungi (Basel, Switzerland) · DOI

Full title: Improved Itaconate Production with Ustilago cynodontis via Co-Metabolism of CO2-Derived Formate.

Authors: Ullmann, Lena; Guntermann, Nils; Kohl, Philipp; Schröders, Gereon; Müsgens, Andreas; Franciò, Giancarlo; Leitner, Walter; Blank, Lars M

Year: 2022

Venue: Journal of fungi (Basel, Switzerland)

DOI: https://doi.org/10.3390/jof8121277

Paper Optimizing Thermoplastic Starch Film with Heteroscedastic Gaussian Processes in Bayesian Experimental Design Framework.

White, Gracie M; Siegel, Amanda P; Tovar, Andres · 2024 · Materials (Basel, Switzerland) · DOI

Full title: Optimizing Thermoplastic Starch Film with Heteroscedastic Gaussian Processes in Bayesian Experimental Design Framework.

Authors: White, Gracie M; Siegel, Amanda P; Tovar, Andres

Year: 2024

Venue: Materials (Basel, Switzerland)

DOI: https://doi.org/10.3390/ma17215345

Paper Impact of the Membrane Structure of the Stationary Phase on Steric Exclusion Chromatography (SXC) of Lentiviral Vectors.

Labisch, Jennifer J; Wiese, G Philip; Pflanz, Karl et al. · 2023 · Membranes · DOI

Full title: Impact of the Membrane Structure of the Stationary Phase on Steric Exclusion Chromatography (SXC) of Lentiviral Vectors.

Authors: Labisch, Jennifer J; Wiese, G Philip; Pflanz, Karl; Linkhorst, John

Year: 2023

Venue: Membranes

DOI: https://doi.org/10.3390/membranes13100849

Paper Screening of a Thraustochytrid Strain Collection for Carotenoid and Squalene Production Characterized by Cluster Analysis, Comparison of 18S rRNA Gene Sequences, Growth Behavior, and Morphology.

Koopmann, Inga K; Müller, Bettina A; Labes, Antje · 2023 · Marine drugs · DOI

Full title: Screening of a Thraustochytrid Strain Collection for Carotenoid and Squalene Production Characterized by Cluster Analysis, Comparison of 18S rRNA Gene Sequences, Growth Behavior, and Morphology.

Authors: Koopmann, Inga K; Müller, Bettina A; Labes, Antje

Year: 2023

Venue: Marine drugs

DOI: https://doi.org/10.3390/md21040204

Paper Dynamic Adsorption of a Cationic Dye onto Wool Fibers as Column-Filling Media: Response Surface Optimization and Fixed-Bed Adsorption Modeling.

Condurache, Bogdan-Constantin; Cojocaru, Corneliu; Bargan, Alexandra et al. · 2024 · Materials (Basel, Switzerland) · DOI

Full title: Dynamic Adsorption of a Cationic Dye onto Wool Fibers as Column-Filling Media: Response Surface Optimization and Fixed-Bed Adsorption Modeling.

Authors: Condurache, Bogdan-Constantin; Cojocaru, Corneliu; Bargan, Alexandra; Samoila, Petrisor; Harabagiu, Valeria

Year: 2024

Venue: Materials (Basel, Switzerland)

DOI: https://doi.org/10.3390/ma17040790

Paper Response surface methodology optimization of fermentation conditions for rapid and efficient accumulation of macrolactin A by marine Bacillus amyloliquefaciens ESB-2.

He, Shan; Wang, Hongqiang; Wu, Bin et al. · 2012 · Molecules (Basel, Switzerland) · DOI

Full title: Response surface methodology optimization of fermentation conditions for rapid and efficient accumulation of macrolactin A by marine Bacillus amyloliquefaciens ESB-2.

Authors: He, Shan; Wang, Hongqiang; Wu, Bin; Zhou, Hui; Zhu, Peng; Yang, Rui; Yan, Xiaojun

Year: 2012

Venue: Molecules (Basel, Switzerland)

DOI: https://doi.org/10.3390/molecules18010408

Paper Scenedesmus rubescens Heterotrophic Production Strategies for Added Value Biomass.

Santo, Gonçalo Espírito; Barros, Ana; Costa, Margarida et al. · 2023 · Marine drugs · DOI

Full title: Scenedesmus rubescens Heterotrophic Production Strategies for Added Value Biomass.

Authors: Santo, Gonçalo Espírito; Barros, Ana; Costa, Margarida; Pereira, Hugo; Trovão, Mafalda; Cardoso, Helena; Carvalho, Bernardo; Soares, Maria; Correia, Nádia; Silva, Joana T; Mateus, Marília; Silva, Joana L

Year: 2023

Venue: Marine drugs

DOI: https://doi.org/10.3390/md21070411

Paper Optimization of PLGA Nanoparticle Formulation via Microfluidic and Batch Nanoprecipitation Techniques.

Kozalak, Gül; Heyat Davoudian, Salar; Natsaridis, Evangelos et al. · 2025 · Micromachines · DOI

Full title: Optimization of PLGA Nanoparticle Formulation via Microfluidic and Batch Nanoprecipitation Techniques.

Authors: Kozalak, Gül; Heyat Davoudian, Salar; Natsaridis, Evangelos; Gogniat, Nubia; Koşar, Ali; Tagit, Oya

Year: 2025

Venue: Micromachines

DOI: https://doi.org/10.3390/mi16090972

Paper DoE Analysis of Approaches for Hydrogel Microbeads' Preparation by Millifluidic Methods.

Nastruzzi, Anna; Pitingolo, Gabriele; Luca, Giovanni et al. · 2020 · Micromachines · DOI

Full title: DoE Analysis of Approaches for Hydrogel Microbeads' Preparation by Millifluidic Methods.

Authors: Nastruzzi, Anna; Pitingolo, Gabriele; Luca, Giovanni; Nastruzzi, Claudio

Year: 2020

Venue: Micromachines

DOI: https://doi.org/10.3390/mi11111007

Paper Optimization of High-Pressure Extraction Process of Antioxidant Compounds from Feteasca regala Leaves Using Response Surface Methodology.

Becze, Anca; Babalau-Fuss, Vanda Liliana; Varaticeanu, Cerasel et al. · 2020 · Molecules (Basel, Switzerland) · DOI

Full title: Optimization of High-Pressure Extraction Process of Antioxidant Compounds from Feteasca regala Leaves Using Response Surface Methodology.

Authors: Becze, Anca; Babalau-Fuss, Vanda Liliana; Varaticeanu, Cerasel; Roman, Cecilia

Year: 2020

Venue: Molecules (Basel, Switzerland)

DOI: https://doi.org/10.3390/molecules25184209

Paper Pigment Production Improvement in Rhodotorula mucilaginosa AJB01 Using Design of Experiments

Garcia-Cortes, Alejandra; Garcia-Vásquez, Julián Andres; Aranguren, Yani et al. · 2021 · Microorganisms · DOI

Full title: Pigment Production Improvement in Rhodotorula mucilaginosa AJB01 Using Design of Experiments

Authors: Garcia-Cortes, Alejandra; Garcia-Vásquez, Julián Andres; Aranguren, Yani; Ramírez-Castrillón, Maurício

Year: 2021

Venue: Microorganisms

DOI: https://doi.org/10.3390/microorganisms9020387

Paper Response Surface Methodology (RSM) Mediated Optimization of Medium Components for Mycelial Growth and Metabolites Production of Streptomyces alfalfae XN-04.

Chen, Jing; Lan, Xingjie; Jia, Ruimin et al. · 2022 · Microorganisms · DOI

Full title: Response Surface Methodology (RSM) Mediated Optimization of Medium Components for Mycelial Growth and Metabolites Production of Streptomyces alfalfae XN-04.

Authors: Chen, Jing; Lan, Xingjie; Jia, Ruimin; Hu, Lifang; Wang, Yang

Year: 2022

Venue: Microorganisms

DOI: https://doi.org/10.3390/microorganisms10091854

Paper Reagent-Free Immobilization of Industrial Lipases to Develop Lipolytic Membranes with Self-Cleaning Surfaces.

Schmidt, Martin; Prager, Andrea; Schönherr, Nadja et al. · 2022 · Membranes · DOI

Full title: Reagent-Free Immobilization of Industrial Lipases to Develop Lipolytic Membranes with Self-Cleaning Surfaces.

Authors: Schmidt, Martin; Prager, Andrea; Schönherr, Nadja; Gläser, Roger; Schulze, Agnes

Year: 2022

Venue: Membranes

DOI: https://doi.org/10.3390/membranes12060599

Paper Improved Artificial Neural Network Training Based on Response Surface Methodology for Membrane Flux Prediction.

Ibrahim, Syahira; Abdul Wahab, Norhaliza · 2022 · Membranes · DOI

Full title: Improved Artificial Neural Network Training Based on Response Surface Methodology for Membrane Flux Prediction.

Authors: Ibrahim, Syahira; Abdul Wahab, Norhaliza

Year: 2022

Venue: Membranes

DOI: https://doi.org/10.3390/membranes12080726

Paper Microwave-Assisted Extraction of Phenolic Compounds from Spent Coffee Grounds. Process Optimization Applying Design of Experiments.

Coelho, José P; Robalo, Maria P; Boyadzhieva, Stanislava et al. · 2021 · Molecules (Basel, Switzerland) · DOI

Full title: Microwave-Assisted Extraction of Phenolic Compounds from Spent Coffee Grounds. Process Optimization Applying Design of Experiments.

Authors: Coelho, José P; Robalo, Maria P; Boyadzhieva, Stanislava; Stateva, Roumiana P

Year: 2021

Venue: Molecules (Basel, Switzerland)

DOI: https://doi.org/10.3390/molecules26237320

Paper Optimization of Lipopeptide Biosurfactant Production by Salibacterium sp. 4CTb in Batch Stirred-Tank Bioreactors.

Márquez-Villa, José Martín; Mateos-Díaz, Juan Carlos; Rodríguez-González, Jorge Alberto et al. · 2022 · Microorganisms · DOI

Full title: Optimization of Lipopeptide Biosurfactant Production by Salibacterium sp. 4CTb in Batch Stirred-Tank Bioreactors.

Authors: Márquez-Villa, José Martín; Mateos-Díaz, Juan Carlos; Rodríguez-González, Jorge Alberto; Camacho-Ruíz, Rosa María

Year: 2022

Venue: Microorganisms

DOI: https://doi.org/10.3390/microorganisms10050983

Paper Characterization and Optimization of the Tyrosinase Inhibitory Activity of Vitis amurensis Root Using LC-Q-TOF-MS Coupled with a Bioassay and Response Surface Methodology

Kyung-Eon Oh; Hyeji Shin; M. Lee et al. · 2021 · Molecules · DOI

Full title: Characterization and Optimization of the Tyrosinase Inhibitory Activity of Vitis amurensis Root Using LC-Q-TOF-MS Coupled with a Bioassay and Response Surface Methodology

Authors: Kyung-Eon Oh; Hyeji Shin; M. Lee; Byoungduck Park; K. Lee

Year: 2021

Venue: Molecules

DOI: https://doi.org/10.3390/molecules26020446

Paper Biosurfactant-Producing Bacteria Isolated from a Microbial Consortium Previously Subjected to Adaptive Laboratory Evolution in Oily Sludge.

Bessa Souza, Maria Clara; Rezende, Rachel Passos; Dotivo, Natielle Cachoeira et al. · 2026 · Microorganisms · DOI

Full title: Biosurfactant-Producing Bacteria Isolated from a Microbial Consortium Previously Subjected to Adaptive Laboratory Evolution in Oily Sludge.

Authors: Bessa Souza, Maria Clara; Rezende, Rachel Passos; Dotivo, Natielle Cachoeira; Freitas, Angelina Moreira de; Aguiar-Oliveira, Elizama; Salay, Luiz Carlos; Marques, Eric de Lima Silva; Moura, Suzana Rodrigues de; Ferreira, Erivelton Santana; Ferreira, Luana Silva; Bonfim, Henrique Andrade Rabelo; Thompson, Fabiano Lopes; Maciel, Bianca Mendes; Dias, João Carlos Teixeira

Year: 2026

Venue: Microorganisms

DOI: https://doi.org/10.3390/microorganisms14020503

Paper Influence of Temperature, Solvent and pH on the Selective Extraction of Phenolic Compounds from Tiger Nuts by-Products: Triple-TOF-LC-MS-MS Characterization

Elena Roselló-Soto; F. J. Martí-Quijal; A. Cilla et al. · 2019 · Molecules · DOI

Full title: Influence of Temperature, Solvent and pH on the Selective Extraction of Phenolic Compounds from Tiger Nuts by-Products: Triple-TOF-LC-MS-MS Characterization

Authors: Elena Roselló-Soto; F. J. Martí-Quijal; A. Cilla; P. E. Munekata; J. Lorenzo; F. Remize; F. Barba

Year: 2019

Venue: Molecules

DOI: https://doi.org/10.3390/molecules24040797

Paper Bioactive Hydrolysates from Chlorella vulgaris: Optimal Process and Bioactive Properties.

Cunha, Sara A; Coscueta, Ezequiel R; Nova, Paulo et al. · 2022 · Molecules (Basel, Switzerland) · DOI

Full title: Bioactive Hydrolysates from Chlorella vulgaris: Optimal Process and Bioactive Properties.

Authors: Cunha, Sara A; Coscueta, Ezequiel R; Nova, Paulo; Silva, Joana Laranjeira; Pintado, Maria Manuela

Year: 2022

Venue: Molecules (Basel, Switzerland)

DOI: https://doi.org/10.3390/molecules27082505

Paper Optimization of Medium Constituents for the Production of Citric Acid from Waste Glycerol Using the Central Composite Rotatable Design of Experiments.

Książek, Ewelina Ewa; Janczar-Smuga, Małgorzata; Pietkiewicz, Jerzy Jan et al. · 2023 · Molecules (Basel, Switzerland) · DOI

Full title: Optimization of Medium Constituents for the Production of Citric Acid from Waste Glycerol Using the Central Composite Rotatable Design of Experiments.

Authors: Książek, Ewelina Ewa; Janczar-Smuga, Małgorzata; Pietkiewicz, Jerzy Jan; Walaszczyk, Ewa

Year: 2023

Venue: Molecules (Basel, Switzerland)

DOI: https://doi.org/10.3390/molecules28073268

Paper User-Driven Strategy for In Silico Screening of Reversed-Phase Liquid Chromatography Conditions for Known Pharmaceutical-Related Small Molecules.

Van Laethem, Thomas; Kumari, Priyanka; Boulanger, Bruno et al. · 2022 · Molecules (Basel, Switzerland) · DOI

Full title: User-Driven Strategy for In Silico Screening of Reversed-Phase Liquid Chromatography Conditions for Known Pharmaceutical-Related Small Molecules.

Authors: Van Laethem, Thomas; Kumari, Priyanka; Boulanger, Bruno; Hubert, Philippe; Fillet, Marianne; Sacré, Pierre-Yves; Hubert, Cédric

Year: 2022

Venue: Molecules (Basel, Switzerland)

DOI: https://doi.org/10.3390/molecules27238306

Paper Optimized Protocol for Microalgae DNA Staining with SYTO9/SYBR Green I, Based on Flow Cytometry and RSM Methodology: Experimental Design, Impacts and Validation.

Ihadjadene, Yob; Walther, Thomas; Krujatz, Felix · 2022 · Methods and protocols · DOI

Full title: Optimized Protocol for Microalgae DNA Staining with SYTO9/SYBR Green I, Based on Flow Cytometry and RSM Methodology: Experimental Design, Impacts and Validation.

Authors: Ihadjadene, Yob; Walther, Thomas; Krujatz, Felix

Year: 2022

Venue: Methods and protocols

DOI: https://doi.org/10.3390/mps5050076

Paper Design of Experiments for Optimizing Ultrasound-Assisted Extraction of Bioactive Compounds from Plant-Based Sources.

Anaya-Esparza, Luis Miguel; Aurora-Vigo, Edward F; Villagrán, Zuamí et al. · 2023 · Molecules (Basel, Switzerland) · DOI

Full title: Design of Experiments for Optimizing Ultrasound-Assisted Extraction of Bioactive Compounds from Plant-Based Sources.

Authors: Anaya-Esparza, Luis Miguel; Aurora-Vigo, Edward F; Villagrán, Zuamí; Rodríguez-Lafitte, Ernesto; Ruvalcaba-Gómez, José Martín; Solano-Cornejo, Miguel Ángel; Zamora-Gasga, Victor Manuel; Montalvo-González, Efigenia; Gómez-Rodríguez, Horacio; Aceves-Aldrete, César Eduardo; González-Silva, Napoleón

Year: 2023

Venue: Molecules (Basel, Switzerland)

DOI: https://doi.org/10.3390/molecules28237752

Paper Application of Experimental Design Methodologies in the Enantioseparation of Pharmaceuticals by Capillary Electrophoresis: A Review.

Hancu, Gabriel; Orlandini, Serena; Papp, Lajos Attila et al. · 2021 · Molecules (Basel, Switzerland) · DOI

Full title: Application of Experimental Design Methodologies in the Enantioseparation of Pharmaceuticals by Capillary Electrophoresis: A Review.

Authors: Hancu, Gabriel; Orlandini, Serena; Papp, Lajos Attila; Modroiu, Adriana; Gotti, Roberto; Furlanetto, Sandra

Year: 2021

Venue: Molecules (Basel, Switzerland)

DOI: https://doi.org/10.3390/molecules26154681

Paper Green Method Comparison and Optimization of Anthocyanin Recovery from "Sangiovese" Grape Pomace: A Critical Evaluation of the Design of Experiments Approach.

Lianza, Mariacaterina; Antognoni, Fabiana · 2024 · Molecules (Basel, Switzerland) · DOI

Full title: Green Method Comparison and Optimization of Anthocyanin Recovery from "Sangiovese" Grape Pomace: A Critical Evaluation of the Design of Experiments Approach.

Authors: Lianza, Mariacaterina; Antognoni, Fabiana

Year: 2024

Venue: Molecules (Basel, Switzerland)

DOI: https://doi.org/10.3390/molecules29112679

Paper Important Aspects of the Design of Experiments and Data Treatment in the Analytical Quality by Design Framework for Chromatographic Method Development.

Passerine, Bianca F G; Breitkreitz, Márcia C · 2024 · Molecules (Basel, Switzerland) · DOI

Full title: Important Aspects of the Design of Experiments and Data Treatment in the Analytical Quality by Design Framework for Chromatographic Method Development.

Authors: Passerine, Bianca F G; Breitkreitz, Márcia C

Year: 2024

Venue: Molecules (Basel, Switzerland)

DOI: https://doi.org/10.3390/molecules29246057

Paper Influence of the Binder Jetting Process Parameters and Binder Liquid Composition on the Relevant Attributes of 3D-Printed Tablets.

Kreft, Klemen; Lavrič, Zoran; Stanić, Tijana et al. · 2022 · Pharmaceutics · DOI

Full title: Influence of the Binder Jetting Process Parameters and Binder Liquid Composition on the Relevant Attributes of 3D-Printed Tablets.

Authors: Kreft, Klemen; Lavrič, Zoran; Stanić, Tijana; Perhavec, Petra; Dreu, Rok

Year: 2022

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics14081568

Paper Design of Experiments to Achieve an Efficient Chitosan-Based DNA Vaccine Delivery System.

Rodolfo, Carlos; Eusébio, Dalinda; Ventura, Cathy et al. · 2021 · Pharmaceutics · DOI

Full title: Design of Experiments to Achieve an Efficient Chitosan-Based DNA Vaccine Delivery System.

Authors: Rodolfo, Carlos; Eusébio, Dalinda; Ventura, Cathy; Nunes, Renato; Florindo, Helena F; Costa, Diana; Sousa, Ângela

Year: 2021

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics13091369

Paper QbD-Based Formulation Development of Amiodarone Hydrochloride Tablet.

Jeon, Chae-Won; Yoon, Ju-Hyun; Kim, Joo-Eun · 2026 · Pharmaceutics · DOI

Full title: QbD-Based Formulation Development of Amiodarone Hydrochloride Tablet.

Authors: Jeon, Chae-Won; Yoon, Ju-Hyun; Kim, Joo-Eun

Year: 2026

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics18020264

Paper Lipid-Based Nanocarriers for Ophthalmic Administration: Towards Experimental Design Implementation.

González-Fernández, Felipe M; Bianchera, Annalisa; Gasco, Paolo et al. · 2021 · Pharmaceutics · DOI

Full title: Lipid-Based Nanocarriers for Ophthalmic Administration: Towards Experimental Design Implementation.

Authors: González-Fernández, Felipe M; Bianchera, Annalisa; Gasco, Paolo; Nicoli, Sara; Pescina, Silvia

Year: 2021

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics13040447

Paper Lipase-Assisted Synthesis of Alkyl Stearates: Optimization by Taguchi Design of Experiments and Application as Defoamers.

Olvera-Ureña, Enoch; Lopez-Tellez, Jorge; Vizueto, M Monserrat et al. · 2023 · Molecules (Basel, Switzerland) · DOI

Full title: Lipase-Assisted Synthesis of Alkyl Stearates: Optimization by Taguchi Design of Experiments and Application as Defoamers.

Authors: Olvera-Ureña, Enoch; Lopez-Tellez, Jorge; Vizueto, M Monserrat; Hidalgo-Ledezma, J Guadalupe; Martinez-Quiroz, Baltazar; Rodriguez, Jose A

Year: 2023

Venue: Molecules (Basel, Switzerland)

DOI: https://doi.org/10.3390/molecules29010195

Paper Process Optimization and Upscaling of Spray-Dried Drug-Amino acid Co-Amorphous Formulations.

Kasten, Georgia; Duarte, Íris; Paisana, Maria et al. · 2019 · Pharmaceutics · DOI

Full title: Process Optimization and Upscaling of Spray-Dried Drug-Amino acid Co-Amorphous Formulations.

Authors: Kasten, Georgia; Duarte, Íris; Paisana, Maria; Löbmann, Korbinian; Rades, Thomas; Grohganz, Holger

Year: 2019

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics11010024

Paper Design and Manufacturing of Antibacterial Electrospun Polysulfone Membranes Functionalized by Ag Nanocoating via Magnetron Sputtering.

Fiaschini, Noemi; Giuliani, Chiara; Vitali, Roberta et al. · 2022 · Nanomaterials (Basel, Switzerland) · DOI

Full title: Design and Manufacturing of Antibacterial Electrospun Polysulfone Membranes Functionalized by Ag Nanocoating via Magnetron Sputtering.

Authors: Fiaschini, Noemi; Giuliani, Chiara; Vitali, Roberta; Tammaro, Loredana; Valerini, Daniele; Rinaldi, Antonio

Year: 2022

Venue: Nanomaterials (Basel, Switzerland)

DOI: https://doi.org/10.3390/nano12223962

Paper Sustainable and Biomimetic Methodology for Extraction of High-Value-Added Compounds in Almond Hulls.

Cremasco, Gabriela; Sutton, Adam T; Funari, Cristiano S et al. · 2024 · Molecules (Basel, Switzerland) · DOI

Full title: Sustainable and Biomimetic Methodology for Extraction of High-Value-Added Compounds in Almond Hulls.

Authors: Cremasco, Gabriela; Sutton, Adam T; Funari, Cristiano S; Arrua, Dario R; Dussan, Kelly J; Hilder, Emily F; Bolzani, Vanderlan S; Rinaldo, Daniel

Year: 2024

Venue: Molecules (Basel, Switzerland)

DOI: https://doi.org/10.3390/molecules29133034

Paper Model-Based Product Temperature and Endpoint Determination in Primary Drying of Lyophilization Processes.

Juckers, Alex; Knerr, Petra; Harms, Frank et al. · 2022 · Pharmaceutics · DOI

Full title: Model-Based Product Temperature and Endpoint Determination in Primary Drying of Lyophilization Processes.

Authors: Juckers, Alex; Knerr, Petra; Harms, Frank; Strube, Jochen

Year: 2022

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics14040809

Paper Optimization of Solid Lipid Nanoparticle Formulation Using Design of Experiments, PART I: Strategic Tool for the Determination of Critical Parameters Regarding Formulation and Process.

Cassayre, Margot; Teles de Souza, Dany; Claeys-Bruno, Magalie et al. · 2025 · Nanomaterials (Basel, Switzerland) · DOI

Full title: Optimization of Solid Lipid Nanoparticle Formulation Using Design of Experiments, PART I: Strategic Tool for the Determination of Critical Parameters Regarding Formulation and Process.

Authors: Cassayre, Margot; Teles de Souza, Dany; Claeys-Bruno, Magalie; Altié, Alexandre; Piccerelle, Philippe; Sauzet, Christophe

Year: 2025

Venue: Nanomaterials (Basel, Switzerland)

DOI: https://doi.org/10.3390/nano15131034

Paper Quality by Design (QbD)-Driven Development and Optimization of Tacrolimus-Loaded Microemulsion for the Treatment of Skin Inflammation.

Srishti, Sanjida Ahmed; Pinky, Paromita Paul; Taylor, Ryan et al. · 2024 · Pharmaceutics · DOI

Full title: Quality by Design (QbD)-Driven Development and Optimization of Tacrolimus-Loaded Microemulsion for the Treatment of Skin Inflammation.

Authors: Srishti, Sanjida Ahmed; Pinky, Paromita Paul; Taylor, Ryan; Guess, Jacob; Karlik, Natasha; Janjic, Jelena M

Year: 2024

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics16121487

Paper The Application of the Design of Experiments and Artificial Neural Networks in the Development of a Fast and Straightforward HPLC-UV Method for Fluconazole Determination in Hemato-Oncologic Pediatric Patients and Its Adaptation to Therapeutic Drug Monitoring.

Adamiszak, Arkadiusz; Czyrski, Andrzej; Sznek, Bartosz et al. · 2024 · Pharmaceuticals (Basel, Switzerland) · DOI

Full title: The Application of the Design of Experiments and Artificial Neural Networks in the Development of a Fast and Straightforward HPLC-UV Method for Fluconazole Determination in Hemato-Oncologic Pediatric Patients and Its Adaptation to Therapeutic Drug Monitoring.

Authors: Adamiszak, Arkadiusz; Czyrski, Andrzej; Sznek, Bartosz; Grześkowiak, Edmund; Bienert, Agnieszka

Year: 2024

Venue: Pharmaceuticals (Basel, Switzerland)

DOI: https://doi.org/10.3390/ph17121679

Paper Quality by Design Micro-Engineering Optimisation of NSAID-Loaded Electrospun Fibrous Patches.

Nazari, Kazem; Mehta, Prina; Arshad, Muhammad Sohail et al. · 2019 · Pharmaceutics · DOI

Full title: Quality by Design Micro-Engineering Optimisation of NSAID-Loaded Electrospun Fibrous Patches.

Authors: Nazari, Kazem; Mehta, Prina; Arshad, Muhammad Sohail; Ahmed, Shahabuddin; Andriotis, Eleftherios G; Singh, Neenu; Qutachi, Omar; Chang, Ming-Wei; Fatouros, Dimitrios G; Ahmad, Zeeshan

Year: 2019

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics12010002

Paper Microfluidics-Assisted Formulation of Polymeric Oxytocin Nanoparticles for Targeted Brain Delivery.

Adediran, Emmanuel; Vijayanand, Sharon; Kale, Akanksha et al. · 2025 · Pharmaceutics · DOI

Full title: Microfluidics-Assisted Formulation of Polymeric Oxytocin Nanoparticles for Targeted Brain Delivery.

Authors: Adediran, Emmanuel; Vijayanand, Sharon; Kale, Akanksha; Gulani, Mahek; Wong, Jennifer C; Escayg, Andrew; Murnane, Kevin S; D'Souza, Martin J

Year: 2025

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics17040452

Paper Aerosolizable Lipid Nanoparticles for Pulmonary Delivery of mRNA through Design of Experiments.

Zhang, Hairui; Leal, Jasmim; Soto, Melissa R et al. · 2020 · Pharmaceutics · DOI

Full title: Aerosolizable Lipid Nanoparticles for Pulmonary Delivery of mRNA through Design of Experiments.

Authors: Zhang, Hairui; Leal, Jasmim; Soto, Melissa R; Smyth, Hugh D C; Ghosh, Debadyuti

Year: 2020

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics12111042

Paper Box–Behnken Design of Experiments of Polycaprolactone Nanoparticles Loaded with Irinotecan Hydrochloride

Mahmoud, Basant Salah; McConville, Christopher · 2023 · Pharmaceutics · DOI

Full title: Box–Behnken Design of Experiments of Polycaprolactone Nanoparticles Loaded with Irinotecan Hydrochloride

Authors: Mahmoud, Basant Salah; McConville, Christopher

Year: 2023

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics15041271

Paper Optimization of Enterovirus-like Particle Production and Purification Using Design of Experiments.

Kuijpers, Louis; van den Braak, Wouter J P; Freydoonian, Abbas et al. · 2025 · Pathogens (Basel, Switzerland) · DOI

Full title: Optimization of Enterovirus-like Particle Production and Purification Using Design of Experiments.

Authors: Kuijpers, Louis; van den Braak, Wouter J P; Freydoonian, Abbas; Dekker, Nynke H; van der Pol, Leo A

Year: 2025

Venue: Pathogens (Basel, Switzerland)

DOI: https://doi.org/10.3390/pathogens14020118

Paper Application of Design of Experiments in the Development of Self-Microemulsifying Drug Delivery Systems.

Hsieh, Chien-Ming; Yang, Ting-Lun; Putri, Athika Darumas et al. · 2023 · Pharmaceuticals (Basel, Switzerland) · DOI

Full title: Application of Design of Experiments in the Development of Self-Microemulsifying Drug Delivery Systems.

Authors: Hsieh, Chien-Ming; Yang, Ting-Lun; Putri, Athika Darumas; Chen, Chin-Tin

Year: 2023

Venue: Pharmaceuticals (Basel, Switzerland)

DOI: https://doi.org/10.3390/ph16020283

Paper Determination of Response Factors for Analytes Detected during Migration Studies, Strategy and Internal Standard Selection for Risk Minimization.

Kritikos, Nikolaos; Bletsou, Anna; Konstantinou, Christina et al. · 2023 · Molecules (Basel, Switzerland) · DOI

Full title: Determination of Response Factors for Analytes Detected during Migration Studies, Strategy and Internal Standard Selection for Risk Minimization.

Authors: Kritikos, Nikolaos; Bletsou, Anna; Konstantinou, Christina; Neofotistos, Antonios-Dionysios; Kousoulos, Constantinos; Dotsikas, Yannis

Year: 2023

Venue: Molecules (Basel, Switzerland)

DOI: https://doi.org/10.3390/molecules28155772

Paper Quality by Design Methodology Applied to Process Optimization and Scale up of Curcumin Nanoemulsions Produced by Catastrophic Phase Inversion.

Adena, Sandeep Kumar Reddy; Herneisey, Michele; Pierce, Eric et al. · 2021 · Pharmaceutics · DOI

Full title: Quality by Design Methodology Applied to Process Optimization and Scale up of Curcumin Nanoemulsions Produced by Catastrophic Phase Inversion.

Authors: Adena, Sandeep Kumar Reddy; Herneisey, Michele; Pierce, Eric; Hartmeier, Paul R; Adlakha, Suneera; Hosfeld, Marco A I; Drennen, James K; Janjic, Jelena M

Year: 2021

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics13060880

Paper Valorization of Turnip Greens (Brassica rapa subsp. sylvestris) Wastes: Investigation on the Sustainable Recovery of Bioactive Extracts with Antioxidant and Antibiofilm Properties.

Maurelli, Anna Maria; Coniglio, Davide; Milano, Francesco et al. · 2026 · Molecules (Basel, Switzerland) · DOI

Full title: Valorization of Turnip Greens (Brassica rapa subsp. sylvestris) Wastes: Investigation on the Sustainable Recovery of Bioactive Extracts with Antioxidant and Antibiofilm Properties.

Authors: Maurelli, Anna Maria; Coniglio, Davide; Milano, Francesco; Mancarella, Sara; Laddomada, Barbara; De Leo, Vincenzo; Longobardi, Francesco; Coppola, Francesca; Fratianni, Florinda; Pascale, Michelangelo; Nazzaro, Filomena; Catucci, Lucia

Year: 2026

Venue: Molecules (Basel, Switzerland)

DOI: https://doi.org/10.3390/molecules31020388

Paper QbD-Based Development and Evaluation of Pazopanib Hydrochloride Extrudates Prepared by Hot-Melt Extrusion Technique: In Vitro and In Vivo Evaluation.

Gupta, Amit; Dahima, Rashmi; Panda, Sunil K et al. · 2024 · Pharmaceutics · DOI

Full title: QbD-Based Development and Evaluation of Pazopanib Hydrochloride Extrudates Prepared by Hot-Melt Extrusion Technique: In Vitro and In Vivo Evaluation.

Authors: Gupta, Amit; Dahima, Rashmi; Panda, Sunil K; Gupta, Annie; Singh, Gaurav Deep; Wani, Tanveer A; Hussain, Afzal; Rathore, Devashish

Year: 2024

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics16060764

Paper Optimized Green Extraction of Polyphenols from Cassia javanica L. Petals for Their Application in Sunflower Oil: Anticancer and Antioxidant Properties

M. I. Younis; Xiaofeng Ren; A. K. Alzubaidi et al. · 2022 · Molecules · DOI

Full title: Optimized Green Extraction of Polyphenols from Cassia javanica L. Petals for Their Application in Sunflower Oil: Anticancer and Antioxidant Properties

Authors: M. I. Younis; Xiaofeng Ren; A. K. Alzubaidi; K. Mahmoud; A. Altemimi; F. Cacciola; Husnain Raza; Anubhav Pratap‐Singh; T. Abedelmaksoud

Year: 2022

Venue: Molecules

DOI: https://doi.org/10.3390/molecules27144329

Paper Can We Simplify Liposome Manufacturing Using a Complex DoE Approach?

Lindsay, Sarah; Tumolva, Olympia; Khamiakova, Tatsiana et al. · 2024 · Pharmaceutics · DOI

Full title: Can We Simplify Liposome Manufacturing Using a Complex DoE Approach?

Authors: Lindsay, Sarah; Tumolva, Olympia; Khamiakova, Tatsiana; Coppenolle, Hans; Kovarik, Martin; Shah, Sanket; Holm, René; Perrie, Yvonne

Year: 2024

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics16091159

Paper Development of Biopredictive Dissolution Method for Extended-Release Desvenlafaxine Tablets.

Carapeto, Gustavo Vaiano; Duque, Marcelo Dutra; Issa, Michele Georges et al. · 2023 · Pharmaceutics · DOI

Full title: Development of Biopredictive Dissolution Method for Extended-Release Desvenlafaxine Tablets.

Authors: Carapeto, Gustavo Vaiano; Duque, Marcelo Dutra; Issa, Michele Georges; Ferraz, Humberto Gomes

Year: 2023

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics15051544

Paper Rheology of Complex Topical Formulations: An Analytical Quality by Design Approach to Method Optimization and Validation.

Chiarentin, Lucas; Cardoso, Catarina; Miranda, Margarida et al. · 2023 · Pharmaceutics · DOI

Full title: Rheology of Complex Topical Formulations: An Analytical Quality by Design Approach to Method Optimization and Validation.

Authors: Chiarentin, Lucas; Cardoso, Catarina; Miranda, Margarida; Vitorino, Carla

Year: 2023

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics15071810

Paper Process Development for the Continuous Manufacturing of Carbamazepine-Nicotinamide Co-Crystals Utilizing Hot-Melt Extrusion Technology.

Huang, Lianghao; Ni, Wen; Jia, Yaru et al. · 2025 · Pharmaceutics · DOI

Full title: Process Development for the Continuous Manufacturing of Carbamazepine-Nicotinamide Co-Crystals Utilizing Hot-Melt Extrusion Technology.

Authors: Huang, Lianghao; Ni, Wen; Jia, Yaru; Zhu, Minqing; Yang, Tiantian; Yu, Mingchao; Zhang, Jiaxiang

Year: 2025

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics17050568

Paper Development of a 3D Printing Liquid Crystal Display (LCD)-Assisted Micromolding Methodology for Custom Fabrication of Polymeric Microneedles Using Experimental Design.

Antonara, Lefkothea; Rekkas, Dimitrios M; Pippa, Natassa et al. · 2025 · Pharmaceutics · DOI

Full title: Development of a 3D Printing Liquid Crystal Display (LCD)-Assisted Micromolding Methodology for Custom Fabrication of Polymeric Microneedles Using Experimental Design.

Authors: Antonara, Lefkothea; Rekkas, Dimitrios M; Pippa, Natassa; Dallas, Paraskevas P

Year: 2025

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics17121571

Paper Intensification of Polyphenols Extraction from Eryngium creticum Leaves Using Ired-Irrad® and Evaluation of Antibiofilm and Antibacterial Activities

M. Hammoud; A. Chokr; H. Rajha et al. · 2022 · Plants · DOI

Full title: Intensification of Polyphenols Extraction from Eryngium creticum Leaves Using Ired-Irrad® and Evaluation of Antibiofilm and Antibacterial Activities

Authors: M. Hammoud; A. Chokr; H. Rajha; C. Safi; Martijn van Walsem; L. A. Broek; Espérance Debs; R. Maroun; N. Louka; H. Rammal

Year: 2022

Venue: Plants

DOI: https://doi.org/10.3390/plants11192458

Paper Artificial neural networks in evaluation and optimization of modified release solid dosage forms.

Ibrić, Svetlana; Djuriš, Jelena; Parojčić, Jelena et al. · 2012 · Pharmaceutics · DOI

Full title: Artificial neural networks in evaluation and optimization of modified release solid dosage forms.

Authors: Ibrić, Svetlana; Djuriš, Jelena; Parojčić, Jelena; Djurić, Zorica

Year: 2012

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics4040531

Paper Optimize, Modulate, and Scale-up Resveratrol and Resveratrol Dimers Bioproduction in Vitis labrusca L. Cell Suspension from Flasks to 20 L Bioreactor

C. Lambert; J. Lemaire; Hélène Auger et al. · 2019 · Plants · DOI

Full title: Optimize, Modulate, and Scale-up Resveratrol and Resveratrol Dimers Bioproduction in Vitis labrusca L. Cell Suspension from Flasks to 20 L Bioreactor

Authors: C. Lambert; J. Lemaire; Hélène Auger; Arnaud Guilleret; R. Reynaud; C. Clément; E. Courot; B. Taidi

Year: 2019

Venue: Plants

DOI: https://doi.org/10.3390/plants8120567

Paper Parameter Screening of PVDF/PVP Multi-Channel Capillary Membranes.

Back, Jan O; Brandstätter, Rupert; Spruck, Martin et al. · 2019 · Polymers · DOI

Full title: Parameter Screening of PVDF/PVP Multi-Channel Capillary Membranes.

Authors: Back, Jan O; Brandstätter, Rupert; Spruck, Martin; Koch, Marc; Penner, Simon; Rupprich, Marco

Year: 2019

Venue: Polymers

DOI: https://doi.org/10.3390/polym11030463

Paper A Design of Experiments Approach to Identify Critical Processing Parameters for Manufacture of an Autologous Platelet Gel for Diabetic Foot Ulcer.

Olszewska, Aleksandra; Egorova, Olga; Gaggia, Gabriella et al. · 2025 · Pharmaceutics · DOI

Full title: A Design of Experiments Approach to Identify Critical Processing Parameters for Manufacture of an Autologous Platelet Gel for Diabetic Foot Ulcer.

Authors: Olszewska, Aleksandra; Egorova, Olga; Gaggia, Gabriella; Mylona, Kalliopi; Pitchford, Simon; Rickard, James; Forbes, Ben

Year: 2025

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics17111482

Paper Aspects and Implementation of Pharmaceutical Quality by Design from Conceptual Frameworks to Industrial Applications.

Yang, Shiwei; Hu, Xingming; Zhu, Jinmiao et al. · 2025 · Pharmaceutics · DOI

Full title: Aspects and Implementation of Pharmaceutical Quality by Design from Conceptual Frameworks to Industrial Applications.

Authors: Yang, Shiwei; Hu, Xingming; Zhu, Jinmiao; Zheng, Bin; Bi, Wenjie; Wang, Xiaohong; Wu, Jialing; Mi, Zimeng; Wu, Yifei

Year: 2025

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics17050623

Paper Experimental and Modeling-Based Approaches for Mechanistic Understanding of Pan Coating Process-A Detailed Review.

Aminahmadi, Behrad; Vaes, Elise; Willemse, Filip et al. · 2025 · Pharmaceutics · DOI

Full title: Experimental and Modeling-Based Approaches for Mechanistic Understanding of Pan Coating Process-A Detailed Review.

Authors: Aminahmadi, Behrad; Vaes, Elise; Willemse, Filip; Braile, Domenica; Gomez, Luz Naranjo; Andersen, Sune Klint; Beer, Thomas De; Kumar, Ashish

Year: 2025

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics18010019

Paper Quality by Design and In Silico Approach in SNEDDS Development: A Comprehensive Formulation Framework.

Priani, Sani Ega; Fakih, Taufik Muhammad; Wilar, Gofarana et al. · 2025 · Pharmaceutics · DOI

Full title: Quality by Design and In Silico Approach in SNEDDS Development: A Comprehensive Formulation Framework.

Authors: Priani, Sani Ega; Fakih, Taufik Muhammad; Wilar, Gofarana; Chaerunisaa, Anis Yohana; Sopyan, Iyan

Year: 2025

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics17060701

Paper Optimization of a Green Ultrasound-Assisted Extraction of Different Polyphenols from Pistacia lentiscus L. Leaves Using a Response Surface Methodology.

Detti, Cassandra; Dos Santos Nascimento, Luana Beatriz; Brunetti, Cecilia et al. · 2020 · Plants (Basel, Switzerland) · DOI

Full title: Optimization of a Green Ultrasound-Assisted Extraction of Different Polyphenols from Pistacia lentiscus L. Leaves Using a Response Surface Methodology.

Authors: Detti, Cassandra; Dos Santos Nascimento, Luana Beatriz; Brunetti, Cecilia; Ferrini, Francesco; Gori, Antonella

Year: 2020

Venue: Plants (Basel, Switzerland)

DOI: https://doi.org/10.3390/plants9111482

Paper Artificial Neural Networks Elucidated the Essential Role of Mineral Nutrients versus Vitamins and Plant Growth Regulators in Achieving Healthy Micropropagated Plants.

Arteta, Tomás A; Hameg, Radhia; Landin, Mariana et al. · 2022 · Plants (Basel, Switzerland) · DOI

Full title: Artificial Neural Networks Elucidated the Essential Role of Mineral Nutrients versus Vitamins and Plant Growth Regulators in Achieving Healthy Micropropagated Plants.

Authors: Arteta, Tomás A; Hameg, Radhia; Landin, Mariana; Gallego, Pedro P; Barreal, M Esther

Year: 2022

Venue: Plants (Basel, Switzerland)

DOI: https://doi.org/10.3390/plants11101284

Paper Design of Experiments-Based Optimization of Flavonoids Extraction from Daphne genkwa Flower Buds and Flavonoids Contents at Different Blooming Stages.

Kim, Min-Kyoung; Park, Geonha; Ji, Yura et al. · 2022 · Plants (Basel, Switzerland) · DOI

Full title: Design of Experiments-Based Optimization of Flavonoids Extraction from Daphne genkwa Flower Buds and Flavonoids Contents at Different Blooming Stages.

Authors: Kim, Min-Kyoung; Park, Geonha; Ji, Yura; Lee, Yun-Gyo; Choi, Minsik; Go, Seung-Hyeon; Son, Miwon; Jang, Young-Pyo

Year: 2022

Venue: Plants (Basel, Switzerland)

DOI: https://doi.org/10.3390/plants11070925

Paper Dissolution of Silk Fibroin in Mixtures of Ionic Liquids and Dimethyl Sulfoxide: On the Relative Importance of Temperature and Binary Solvent Composition.

El Seoud, Omar A; Kostag, Marc; Possidonio, Shirley et al. · 2021 · Polymers · DOI

Full title: Dissolution of Silk Fibroin in Mixtures of Ionic Liquids and Dimethyl Sulfoxide: On the Relative Importance of Temperature and Binary Solvent Composition.

Authors: El Seoud, Omar A; Kostag, Marc; Possidonio, Shirley; Dignani, Marcella T; Pires, Paulo A R; Lourenço, Matheus C

Year: 2021

Venue: Polymers

DOI: https://doi.org/10.3390/polym14010013

Paper History, Phylogeny, Biodiversity, and New Computer-Based Tools for Efficient Micropropagation and Conservation of Pistachio (Pistacia spp.) Germplasm.

Nezami, Esmaeil; Gallego, Pedro P · 2023 · Plants (Basel, Switzerland) · DOI

Full title: History, Phylogeny, Biodiversity, and New Computer-Based Tools for Efficient Micropropagation and Conservation of Pistachio (Pistacia spp.) Germplasm.

Authors: Nezami, Esmaeil; Gallego, Pedro P

Year: 2023

Venue: Plants (Basel, Switzerland)

DOI: https://doi.org/10.3390/plants12020323

Paper Experimental Design in Polymer Chemistry-A Guide towards True Optimization of a RAFT Polymerization Using Design of Experiments (DoE).

Eckert, Tilman; Klein, Florian C; Frieler, Piet et al. · 2021 · Polymers · DOI

Full title: Experimental Design in Polymer Chemistry-A Guide towards True Optimization of a RAFT Polymerization Using Design of Experiments (DoE).

Authors: Eckert, Tilman; Klein, Florian C; Frieler, Piet; Thunich, Oliver; Abetz, Volker

Year: 2021

Venue: Polymers

DOI: https://doi.org/10.3390/polym13183147

Paper Extraction, Isolation, Screening, and Preliminary Characterization of Polysaccharides with Anti–Oxidant Activities from Oudemansiella raphanipies

Junqiang Qiu; Wang Shi; Jingnan Miao et al. · 2023 · Polymers · DOI

Full title: Extraction, Isolation, Screening, and Preliminary Characterization of Polysaccharides with Anti–Oxidant Activities from Oudemansiella raphanipies

Authors: Junqiang Qiu; Wang Shi; Jingnan Miao; Hui Hu; Yanan Gao

Year: 2023

Venue: Polymers

DOI: https://doi.org/10.3390/polym15132917

Paper The Use of Response Surface Methodology to Optimize Assisted Extraction of Bioactive Compounds from Cucurbita maxima Fruit By-Products

R. B. Mansour; H. Falleh; M. Hammami et al. · 2023 · Processes · DOI

Full title: The Use of Response Surface Methodology to Optimize Assisted Extraction of Bioactive Compounds from Cucurbita maxima Fruit By-Products

Authors: R. B. Mansour; H. Falleh; M. Hammami; L. Barros; S. Petropoulos; N. Tarchoun; R. Ksouri

Year: 2023

Venue: Processes

DOI: https://doi.org/10.3390/pr11061726

Paper Fused-Filament Fabrication of Short Carbon Fiber-Reinforced Polyamide: Parameter Optimization for Improved Performance under Uniaxial Tensile Loading.

Belei, Carlos; Joeressen, Jana; Amancio-Filho, Sergio T · 2022 · Polymers · DOI

Full title: Fused-Filament Fabrication of Short Carbon Fiber-Reinforced Polyamide: Parameter Optimization for Improved Performance under Uniaxial Tensile Loading.

Authors: Belei, Carlos; Joeressen, Jana; Amancio-Filho, Sergio T

Year: 2022

Venue: Polymers

DOI: https://doi.org/10.3390/polym14071292

Paper A Design of Experiments (DoE) Approach to Optimize Cryogel Manufacturing for Tissue Engineering Applications.

Carvalho, Duarte Nuno; Gonçalves, Cristiana; Oliveira, Joaquim Miguel et al. · 2022 · Polymers · DOI

Full title: A Design of Experiments (DoE) Approach to Optimize Cryogel Manufacturing for Tissue Engineering Applications.

Authors: Carvalho, Duarte Nuno; Gonçalves, Cristiana; Oliveira, Joaquim Miguel; Williams, David S; Mearns-Spragg, Andrew; Reis, Rui L; Silva, Tiago H

Year: 2022

Venue: Polymers

DOI: https://doi.org/10.3390/polym14102026

Paper Modeling, the Optimization of the Composition of Emulgels with Ciclopirox Olamine, and Quality Assessment.

Mazurkeviciute, Agne; Matulyte, Inga; Ivaskiene, Marija et al. · 2024 · Polymers · DOI

Full title: Modeling, the Optimization of the Composition of Emulgels with Ciclopirox Olamine, and Quality Assessment.

Authors: Mazurkeviciute, Agne; Matulyte, Inga; Ivaskiene, Marija; Zilius, Modestas

Year: 2024

Venue: Polymers

DOI: https://doi.org/10.3390/polym16131816

Paper Optimization of Polyacrylic Acid Coating on Graphene Oxide-Functionalized Reverse-Osmosis Membrane Using UV Radiation through Response Surface Methodology.

Ashfaq, Mohammad Yousaf; Al-Ghouti, Mohammad A · 2022 · Polymers · DOI

Full title: Optimization of Polyacrylic Acid Coating on Graphene Oxide-Functionalized Reverse-Osmosis Membrane Using UV Radiation through Response Surface Methodology.

Authors: Ashfaq, Mohammad Yousaf; Al-Ghouti, Mohammad A

Year: 2022

Venue: Polymers

DOI: https://doi.org/10.3390/polym14183711

Paper Analytical Enantio-Separation of Linagliptin in Linagliptin and Metformin HCl Dosage Forms by Applying Two-Level Factorial Design.

Jadhav, Sushant B; Mane, Rahul M; Narayanan, Kalyanraman L et al. · 2016 · Scientia pharmaceutica · DOI

Full title: Analytical Enantio-Separation of Linagliptin in Linagliptin and Metformin HCl Dosage Forms by Applying Two-Level Factorial Design.

Authors: Jadhav, Sushant B; Mane, Rahul M; Narayanan, Kalyanraman L; Bhosale, Popatrao N

Year: 2016

Venue: Scientia pharmaceutica

DOI: https://doi.org/10.3390/scipharm84040671

Paper Analyzing Homogeneity of Highly Viscous Polymer Suspensions in Change Can Mixers.

Larsen, Michael Roland; Holmen Olofsson, Erik Tomas; Spangenberg, Jon · 2024 · Polymers · DOI

Full title: Analyzing Homogeneity of Highly Viscous Polymer Suspensions in Change Can Mixers.

Authors: Larsen, Michael Roland; Holmen Olofsson, Erik Tomas; Spangenberg, Jon

Year: 2024

Venue: Polymers

DOI: https://doi.org/10.3390/polym16182675

Paper A Novel Approach for the Estimation of the Efficiency of Demulsification of Water-In-Crude Oil Emulsions.

Nešić, Slavko; Govedarica, Olga; Jovičić, Mirjana et al. · 2025 · Polymers · DOI

Full title: A Novel Approach for the Estimation of the Efficiency of Demulsification of Water-In-Crude Oil Emulsions.

Authors: Nešić, Slavko; Govedarica, Olga; Jovičić, Mirjana; Žeravica, Julijana; Stojanov, Sonja; Antić, Cvijan; Govedarica, Dragan

Year: 2025

Venue: Polymers

DOI: https://doi.org/10.3390/polym17212957

Paper Optimization and Modeling of Citrobacter freundii AD119 Growth and 1,3-Propanediol Production Using Two-Step Statistical Experimental Design and Artificial Neural Networks

A. Drożdżyńska; J. Wawrzyniak; P. Kubiak et al. · 2023 · Italian National Conference on Sensors · DOI

Full title: Optimization and Modeling of Citrobacter freundii AD119 Growth and 1,3-Propanediol Production Using Two-Step Statistical Experimental Design and Artificial Neural Networks

Authors: A. Drożdżyńska; J. Wawrzyniak; P. Kubiak; Martyna Przybylak; W. Białas; K. Czaczyk

Year: 2023

Venue: Italian National Conference on Sensors

DOI: https://doi.org/10.3390/s23031266

Paper Enhancing Process Control and Quality in Amorphous Solid Dispersions Using In-Line UV-Vis Monitoring of L* as a Real-Time Response.

Bezerra, Mariana; Almeida, Juan; de Castro, Matheus et al. · 2025 · Pharmaceutics · DOI

Full title: Enhancing Process Control and Quality in Amorphous Solid Dispersions Using In-Line UV-Vis Monitoring of L* as a Real-Time Response.

Authors: Bezerra, Mariana; Almeida, Juan; de Castro, Matheus; Grootveld, Martin; Schlindwein, Walkiria

Year: 2025

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics17020151

Paper Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors.

Graf, Alexander; Woodhams, Angus; Nelson, Michael et al. · 2022 · Sensors (Basel, Switzerland) · DOI

Full title: Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors.

Authors: Graf, Alexander; Woodhams, Angus; Nelson, Michael; Richardson, Douglas D; Short, Steven M; Brower, Mark; Hoehse, Marek

Year: 2022

Venue: Sensors (Basel, Switzerland)

DOI: https://doi.org/10.3390/s22093397

Paper Biogas Upgrading by Pressure Swing Adsorption with Design of Experiments

Chen, Yi-Fang; Lin, Po-Wei; Chen, Wen‐Hua et al. · 2021 · Processes · DOI

Full title: Biogas Upgrading by Pressure Swing Adsorption with Design of Experiments

Authors: Chen, Yi-Fang; Lin, Po-Wei; Chen, Wen‐Hua; Yen, Fong-Yu; Yang, Hong-Sung; Chou, Cheng-Tung

Year: 2021

Venue: Processes

DOI: https://doi.org/10.3390/pr9081325

Paper Comparison of four functionalization methods of gold nanoparticles for enhancing the enzyme-linked immunosorbent assay (ELISA).

Ciaurriz, Paula; Fernández, Fátima; Tellechea, Edurne et al. · 2017 · Beilstein journal of nanotechnology · DOI

Full title: Comparison of four functionalization methods of gold nanoparticles for enhancing the enzyme-linked immunosorbent assay (ELISA).

Authors: Ciaurriz, Paula; Fernández, Fátima; Tellechea, Edurne; Moran, Jose F; Asensio, Aaron C

Year: 2017

Venue: Beilstein journal of nanotechnology

DOI: https://doi.org/10.3762/bjnano.8.27

Paper Challenges and Opportunities in the Process Development of Chimeric Vaccines.

Chauhan, Shivani; Khasa, Yogender Pal · 2023 · Vaccines · DOI

Full title: Challenges and Opportunities in the Process Development of Chimeric Vaccines.

Authors: Chauhan, Shivani; Khasa, Yogender Pal

Year: 2023

Venue: Vaccines

DOI: https://doi.org/10.3390/vaccines11121828

Paper Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A-F Employing Taguchi Design-of-Experiments.

von Berg, Laura; Stern, Daniel; Weisemann, Jasmin et al. · 2019 · Toxins · DOI

Full title: Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A-F Employing Taguchi Design-of-Experiments.

Authors: von Berg, Laura; Stern, Daniel; Weisemann, Jasmin; Rummel, Andreas; Dorner, Martin Bernhard; Dorner, Brigitte Gertrud

Year: 2019

Venue: Toxins

DOI: https://doi.org/10.3390/toxins11100588

Paper Development of Long-Term Stability of Enveloped rVSV Viral Vector Expressing SARS-CoV-2 Antigen Using a DOE-Guided Approach.

Khan, M D Faizul Hussain; Wagner, Caroline E; Kamen, Amine A · 2024 · Vaccines · DOI

Full title: Development of Long-Term Stability of Enveloped rVSV Viral Vector Expressing SARS-CoV-2 Antigen Using a DOE-Guided Approach.

Authors: Khan, M D Faizul Hussain; Wagner, Caroline E; Kamen, Amine A

Year: 2024

Venue: Vaccines

DOI: https://doi.org/10.3390/vaccines12111240

Paper Implementation of a Design of Experiments to Improve Periplasmic Yield of Functional ScFv Antibodies in a Phage Display Platform.

Aghdam, Marjan Abri; Tohidkia, Mohammad Reza; Ghamghami, Elham et al. · 2022 · Advanced pharmaceutical bulletin · DOI

Full title: Implementation of a Design of Experiments to Improve Periplasmic Yield of Functional ScFv Antibodies in a Phage Display Platform.

Authors: Aghdam, Marjan Abri; Tohidkia, Mohammad Reza; Ghamghami, Elham; Ahmadikhah, Asadollah; Khanmahamadi, Morteza; Baradaran, Behzad; Mokhtarzadeh, Ahad

Year: 2022

Venue: Advanced pharmaceutical bulletin

DOI: https://doi.org/10.34172/apb.2022.061

Paper Optimization, Production, Purification and Characterization of HIV-1 GAG-Based Virus-like Particles Functionalized with SARS-CoV-2.

Boix-Besora, Arnau; Lorenzo, Elianet; Lavado-García, Jesús et al. · 2022 · Vaccines · DOI

Full title: Optimization, Production, Purification and Characterization of HIV-1 GAG-Based Virus-like Particles Functionalized with SARS-CoV-2.

Authors: Boix-Besora, Arnau; Lorenzo, Elianet; Lavado-García, Jesús; Gòdia, Francesc; Cervera, Laura

Year: 2022

Venue: Vaccines

DOI: https://doi.org/10.3390/vaccines10020250

Paper Optimization of Phenolic Compound Extraction from Brewers’ Spent Grain Using Ultrasound Technologies Coupled with Response Surface Methodology

Rosamaria Iadecola; R. Ciccoritti; B. Ceccantoni et al. · 2022 · Sustainability · DOI

Full title: Optimization of Phenolic Compound Extraction from Brewers’ Spent Grain Using Ultrasound Technologies Coupled with Response Surface Methodology

Authors: Rosamaria Iadecola; R. Ciccoritti; B. Ceccantoni; A. Bellincontro; T. Amoriello

Year: 2022

Venue: Sustainability

DOI: https://doi.org/10.3390/su14063309

Paper Optimization of Spray Drying Parameters for White Dragon Fruit (Hylocereus undatus) Juice Powder using Response Surface Methodology (RSM)

N. Yusof; N. Adzahan; Kharidah Muhammad · 2020 · Malaysian Journal of Applied Sciences · DOI

Full title: Optimization of Spray Drying Parameters for White Dragon Fruit (Hylocereus undatus) Juice Powder using Response Surface Methodology (RSM)

Authors: N. Yusof; N. Adzahan; Kharidah Muhammad

Year: 2020

Venue: Malaysian Journal of Applied Sciences

DOI: https://doi.org/10.37231/myjas.2020.5.2.262

Paper Self-optimisation and model-based design of experiments for developing a C–H activation flow process

Echtermeyer, Alexander Walter Wilhelm; Amar, Yehia; Zakrzewski, J. et al. · 2017 · Beilstein Journal of Organic Chemistry · DOI

Full title: Self-optimisation and model-based design of experiments for developing a C–H activation flow process

Authors: Echtermeyer, Alexander Walter Wilhelm; Amar, Yehia; Zakrzewski, J.; Lapkin, Alexei A.

Year: 2017

Venue: Beilstein Journal of Organic Chemistry

DOI: https://doi.org/10.3762/bjoc.13.18

Paper Optimization of biodiesel production from spent cooking oil by fungal lipase using response surface methodology

S. O. Kareem; Olayinka Quadri Adio; M. Osho et al. · 2018 · Nigerian Journal of Biotechnology · DOI

Full title: Optimization of biodiesel production from spent cooking oil by fungal lipase using response surface methodology

Authors: S. O. Kareem; Olayinka Quadri Adio; M. Osho; T. Banjo; S. O. Omeike

Year: 2018

Venue: Nigerian Journal of Biotechnology

DOI: https://doi.org/10.4314/njb.v35i1.4

Paper Statistical Approaches With Emphasis on Design of Experiments Applied to Chemical Processes

Silva, Valter · 2018 · InTech eBooks · DOI

Full title: Statistical Approaches With Emphasis on Design of Experiments Applied to Chemical Processes

Authors: Silva, Valter

Year: 2018

Venue: InTech eBooks

DOI: https://doi.org/10.5772/65616

Paper Isolation of Total Saponins from Sapindus mukorossi Gaerth

Menghao Du; Sume Huang; Jinping Zhang et al. · 2014 · Journal of Forestry · DOI

Full title: Isolation of Total Saponins from Sapindus mukorossi Gaerth

Authors: Menghao Du; Sume Huang; Jinping Zhang; Jingwen Wang; Lisong Hu; Jingmin Jiang

Year: 2014

Venue: Journal of Forestry

DOI: https://doi.org/10.4236/ojf.2014.41004

Paper Hybridization of Selected Nigerian Lignocellulosic Biomass Feedstocks for Bioethanol Production: Modeling and Optimization of Pretreatment and Fermentation Process Parameters Using Response Surface Methodology.

Awoyale, Adeolu A; Lokhat, David · 2021 · Journal of oleo science · DOI

Full title: Hybridization of Selected Nigerian Lignocellulosic Biomass Feedstocks for Bioethanol Production: Modeling and Optimization of Pretreatment and Fermentation Process Parameters Using Response Surface Methodology.

Authors: Awoyale, Adeolu A; Lokhat, David

Year: 2021

Venue: Journal of oleo science

DOI: https://doi.org/10.5650/jos.ess21038

Paper Optimization of ultrasonic-assisted enzymatic hydrolysis conditions for the production of antioxidant hydrolysates from porcine liver by using response surface methodology

Hui-Chuan Yu; F. Tan · 2017 · Asian-Australasian Journal of Animal Sciences · DOI

Full title: Optimization of ultrasonic-assisted enzymatic hydrolysis conditions for the production of antioxidant hydrolysates from porcine liver by using response surface methodology

Authors: Hui-Chuan Yu; F. Tan

Year: 2017

Venue: Asian-Australasian Journal of Animal Sciences

DOI: https://doi.org/10.5713/ajas.16.0807

Paper Isolation and culture medium optimisation using one-factor-at-time and Response Surface Methodology on the biodegradation of the azo-dye amaranth

Noris Kartika Sari Islahuddin; M. Halmi; M. Manogaran et al. · 2017 · Bioremediation Science and Technology Research · DOI

Full title: Isolation and culture medium optimisation using one-factor-at-time and Response Surface Methodology on the biodegradation of the azo-dye amaranth

Authors: Noris Kartika Sari Islahuddin; M. Halmi; M. Manogaran; M. Shukor

Year: 2017

Venue: Bioremediation Science and Technology Research

DOI: https://doi.org/10.54987/bstr.v5i2.360

Paper State-of-the-Art Review of Design of Experiments for Physics-Informed Deep Learning

Das, Sourav; Tesfamariam, Solomon · 2022 · arXiv (Cornell University) · DOI

Full title: State-of-the-Art Review of Design of Experiments for Physics-Informed Deep Learning

Authors: Das, Sourav; Tesfamariam, Solomon

Year: 2022

Venue: arXiv (Cornell University)

DOI: https://doi.org/10.48550/arxiv.2202.06416

Paper A Taguchi Design of Experiments Approach for Untargeted Metabolomics Sample Preparation Optimization.

Garcia, Brianna M; Gouveia, Goncalo J; Shaver, Amanda O et al. · 2025 · Journal of biomolecular techniques : JBT · DOI

Full title: A Taguchi Design of Experiments Approach for Untargeted Metabolomics Sample Preparation Optimization.

Authors: Garcia, Brianna M; Gouveia, Goncalo J; Shaver, Amanda O; Borges, Ricardo M; Amster, I Jonathan; Edison, Arthur S; Iii, Franklin E Leach

Year: 2025

Venue: Journal of biomolecular techniques : JBT

DOI: https://doi.org/10.7171/3fc1f5fe.54585830

Paper Application of Taguchi-Based Design of Experiments for Industrial Chemical Processes

Davis, Rahul; John, Pretesh · 2018 · InTech eBooks · DOI

Full title: Application of Taguchi-Based Design of Experiments for Industrial Chemical Processes

Authors: Davis, Rahul; John, Pretesh

Year: 2018

Venue: InTech eBooks

DOI: https://doi.org/10.5772/intechopen.69501

Paper Use of design of experiments to optimize the production of microbial probiotic biofilms.

Speranza, Barbara; Liso, Arcangelo; Corbo, Maria Rosaria · 2018 · PeerJ · DOI

Full title: Use of design of experiments to optimize the production of microbial probiotic biofilms.

Authors: Speranza, Barbara; Liso, Arcangelo; Corbo, Maria Rosaria

Year: 2018

Venue: PeerJ

DOI: https://doi.org/10.7717/peerj.4826

Paper A first course in design and analysis of experiments

Oehlert, Gary W. · 2000 · University of Minnesota Digital Conservancy (University of Minnesota)

Full title: A first course in design and analysis of experiments

Authors: Oehlert, Gary W.

Year: 2000

Venue: University of Minnesota Digital Conservancy (University of Minnesota)

Paper Rotatable central composite design of experiments versus Taguchi method in the optimization of turning

Cukor, Goran; Jurković, Zoran; Sekulić, Milenko · 2011 · University of Zagreb University Computing Centre (SRCE)

Full title: Rotatable central composite design of experiments versus Taguchi method in the optimization of turning

Authors: Cukor, Goran; Jurković, Zoran; Sekulić, Milenko

Year: 2011

Venue: University of Zagreb University Computing Centre (SRCE)

Thesis Optimisation of Multiple Response Processes Using Different Modeling Techniques

Silva, Messias Borges · 2023 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Optimisation of Multiple Response Processes Using Different Modeling Techniques

Authors: Silva, Messias Borges

Year: 2023

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.12776/qip.v27i3.1899

Thesis Design of Experiments (DoE) applied to Pharmaceutical and Analytical Quality by Design (QbD)

Lourenço, Felipe Rebello · 2018 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Design of Experiments (DoE) applied to Pharmaceutical and Analytical Quality by Design (QbD)

Authors: Lourenço, Felipe Rebello

Year: 2018

Venue: Universidade de São Paulo – USP Digital Library

DOI: http://www.scielo.br/pdf/bjps/v54nspe/2175-9790-bjps-54-spe-e01006.pdf

Thesis Design of experiments approach for the development of a validated method to determine the exenatide content in poly(lactide-co-glycolide) microspheres

Sheikhi, Mojgan; Sharifzadeh, Mohammad; Hennink, Wim E. et al. · 2023 · Utrecht University · DOI

Full title: Design of experiments approach for the development of a validated method to determine the exenatide content in poly(lactide-co-glycolide) microspheres

Authors: Sheikhi, Mojgan; Sharifzadeh, Mohammad; Hennink, Wim E.; Firoozpour, Loghman; Hajimahmoodi, Mannan; Khoshayand, Mohammad Reza; Shirangi, Mehrnoosh

Year: 2023

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/435878

Thesis Optimal experimental design for calibration of bioprocess models : a validated software toolbox

De Pauw, Dirk · 2005 · Ghent University (Universiteit Gent) · DOI

Full title: Optimal experimental design for calibration of bioprocess models : a validated software toolbox

Authors: De Pauw, Dirk

Year: 2005

Venue: Ghent University (Universiteit Gent)

DOI: https://biblio.ugent.be/publication/472062

Thesis Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022 · KTH Royal Institute of Technology · DOI

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

Year: 2022

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis Advancing Cell Culture Engineering Through Mechanistic Model Optimization

O'Brien, Conor · 2020 · University of Minnesota - Digital Conservancy · DOI

Full title: Advancing Cell Culture Engineering Through Mechanistic Model Optimization

Authors: O'Brien, Conor

Year: 2020

Venue: University of Minnesota - Digital Conservancy

DOI: http://hdl.handle.net/11299/215059

Thesis Development of a framework for descriptive and quantitative analysis of biotechnological processes

Carrillo Le Roux, Galo Antonio · 2025 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Development of a framework for descriptive and quantitative analysis of biotechnological processes

Authors: Carrillo Le Roux, Galo Antonio

Year: 2025

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://www.teses.usp.br/teses/disponiveis/3/3137/tde-25092025-104431/pt-br.php

Thesis Algorithmic co-optimization of genetic constructs and growth conditions: application to 6-ACA, a potential nylon-6 precursor

Zhou, Hui; Vonk, Brenda; Roubos, Johannes A. et al. · 2016 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Algorithmic co-optimization of genetic constructs and growth conditions: application to 6-ACA, a potential nylon-6 precursor

Authors: Zhou, Hui; Vonk, Brenda; Roubos, Johannes A.; Voigt, Christopher A.; Bovenberg, Roel A. L.

Year: 2016

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/100578

Thesis Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Murayyan, Abdulmonem · 2013 · University of Guelph · DOI

Full title: Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Authors: Murayyan, Abdulmonem

Year: 2013

Venue: University of Guelph

DOI: http://hdl.handle.net/10214/6604

Thesis Bioprocess Strategies for the Production of Designer Rhamnolipid Biosurfactants

Nasser, Makary · 2025 · University of Guelph · DOI

Full title: Bioprocess Strategies for the Production of Designer Rhamnolipid Biosurfactants

Authors: Nasser, Makary

Year: 2025

Venue: University of Guelph

DOI: https://hdl.handle.net/10214/28811

Thesis Rapid optimization of processes for the integrated purification of biopharmaceuticals

Crowell, Laura E; Rodriguez, Sergio A; Love, Kerry R et al. · 2021 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Rapid optimization of processes for the integrated purification of biopharmaceuticals

Authors: Crowell, Laura E; Rodriguez, Sergio A; Love, Kerry R; Cramer, Steven M; Love, J Christopher

Year: 2021

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/135519

Thesis Design of experiments for model-based optimization

Singh, Prashant · 2016 · Ghent University (Universiteit Gent) · DOI

Full title: Design of experiments for model-based optimization

Authors: Singh, Prashant

Year: 2016

Venue: Ghent University (Universiteit Gent)

DOI: https://biblio.ugent.be/publication/7223691

Thesis Tradespace as a decision making tool in bioprocess design

Tang, Yu-wen, S.M. Massachusetts Institute of Technology · 2017 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Tradespace as a decision making tool in bioprocess design

Authors: Tang, Yu-wen, S.M. Massachusetts Institute of Technology

Year: 2017

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/107362

Thesis Computation and predictive modeling to increase efficiency and performance in cell line and bioprocess development

Baskerville-Bridges, Aaron(Aaron Davis) · 2020 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Computation and predictive modeling to increase efficiency and performance in cell line and bioprocess development

Authors: Baskerville-Bridges, Aaron(Aaron Davis)

Year: 2020

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/126944

Thesis Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Hong, Moo Sun · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Authors: Hong, Moo Sun

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/138943

Thesis Model‐based control for column‐based continuous viral inactivation of biopharmaceuticals

Hong, Moo Sun; Lu, Amos E.; Ou, Rui Wen et al. · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Model‐based control for column‐based continuous viral inactivation of biopharmaceuticals

Authors: Hong, Moo Sun; Lu, Amos E.; Ou, Rui Wen; Wolfrum, Jacqueline M.; Springs, Stacy L.; Sinskey, Anthony J.; Braatz, Richard D.

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/140434

Thesis A central composite design to investigate antibody fragment production by Pichia pastoris

Chan, Joyce, M. Eng. Massachusetts Institute of Technology · 2006 · Massachusetts Institute of Technology (MIT) · DOI

Full title: A central composite design to investigate antibody fragment production by Pichia pastoris

Authors: Chan, Joyce, M. Eng. Massachusetts Institute of Technology

Year: 2006

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/33872

Thesis Dynamic flow experiments for Bayesian optimization of a single process objective

Florit, Federico; Nandiwale, Kakasaheb Y; Armstrong, Cameron T et al. · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Dynamic flow experiments for Bayesian optimization of a single process objective

Authors: Florit, Federico; Nandiwale, Kakasaheb Y; Armstrong, Cameron T; Grohowalski, Katharina; Diaz, Angel R; Mustakis, Jason; Guinness, Steven M; Jensen, Klavs F

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/162459

Thesis Bayesian Inference and Experimental Design of Combustion Kinetic Models

Chen, Huaibo · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Bayesian Inference and Experimental Design of Combustion Kinetic Models

Authors: Chen, Huaibo

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/153682

Thesis Optimal replicates for designed experiments under the online framework

Sudarsanam, Nandan; Pitchai Kannu, Balaji; Frey, Daniel · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Optimal replicates for designed experiments under the online framework

Authors: Sudarsanam, Nandan; Pitchai Kannu, Balaji; Frey, Daniel

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/131804.2

Thesis Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel et al. · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Authors: Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel; Dang, Brendan; Wolffe, Lenna A; Atari, Adel; Tseng, Yuen-Yi; Love, J Christopher

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/163220

Thesis Preemptive variation reduction in biologic drug substance manufacturing

Güereca Valdivia, Ismael · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Preemptive variation reduction in biologic drug substance manufacturing

Authors: Güereca Valdivia, Ismael

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/155982

Thesis Automated Optimization and Control of Modular Chemical Systems

Nikolakopoulou, Anastasia · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Automated Optimization and Control of Modular Chemical Systems

Authors: Nikolakopoulou, Anastasia

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/143234

Thesis Metabolomics and machine learning to assist biotechnology culture optimisation

Valencia Albornoz, Ricardo Gabriel · 2025 · The University of Edinburgh · DOI

Full title: Metabolomics and machine learning to assist biotechnology culture optimisation

Authors: Valencia Albornoz, Ricardo Gabriel

Year: 2025

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/43540

Thesis Characterizing Hollow Fiber Membranes an Application of Sequential Design of Experiments

Nemetz, Leo Richard · 2023 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Characterizing Hollow Fiber Membranes an Application of Sequential Design of Experiments

Authors: Nemetz, Leo Richard

Year: 2023

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1678927636676011

Thesis Sequential, Batch and Multi-Objective Bayesian Design of Experiments for Additive Manufacturing Processes

Harding, Guy · 2023 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Sequential, Batch and Multi-Objective Bayesian Design of Experiments for Additive Manufacturing Processes

Authors: Harding, Guy

Year: 2023

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/33550/1/Updated%20Thesis%20GuyHarding.pdf

Thesis Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Cosenza, Zachary Anthony · 2022 · University of California, Davis · DOI

Full title: Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Authors: Cosenza, Zachary Anthony

Year: 2022

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/119489fc

Thesis Experimental planning and sequential kriging optimization using variable fidelity data

Huang, Deng · 2005 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Experimental planning and sequential kriging optimization using variable fidelity data

Authors: Huang, Deng

Year: 2005

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1110297243

Thesis Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection-A Simulation Study

Hernandez Rodriguez, Tanja; Morerod, Sophie; Poertner, Ralf et al. · 2021 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection-A Simulation Study

Authors: Hernandez Rodriguez, Tanja; Morerod, Sophie; Poertner, Ralf; Wurm, Florian M.; Frahm, Bjorn

Year: 2021

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/180009

Thesis Modern design of experiments methods for screening and experimentations with mixture and qualitative variables

Chantarat, Navara · 2003 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Modern design of experiments methods for screening and experimentations with mixture and qualitative variables

Authors: Chantarat, Navara

Year: 2003

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1064198056

Thesis Impact of Dispersion Effect on Model Selection for Definitive Screening Designs

Torsu, Blessing Anarfi-Dziwornu · 2023 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Impact of Dispersion Effect on Model Selection for Definitive Screening Designs

Authors: Torsu, Blessing Anarfi-Dziwornu

Year: 2023

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1683655390292968

Thesis White-Box Approaches to Cell Culture Media Optimization for Cultivated Meat

O'Neill, Edward N · 2024 · University of California, Davis · DOI

Full title: White-Box Approaches to Cell Culture Media Optimization for Cultivated Meat

Authors: O'Neill, Edward N

Year: 2024

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/9920t5d7

Thesis Optimisation of plasma sprayed hydroxyapatite coatings using a design of experiments approach

Kuntin, David · 2020 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Optimisation of plasma sprayed hydroxyapatite coatings using a design of experiments approach

Authors: Kuntin, David

Year: 2020

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/28155/1/Kuntin_201043602_Thesis.pdf

Thesis Pharmaceutical process optimisation: Decision support under high uncertainty

Pham, TD; Manapragada, C; Rajan, N et al. · 2022 · University of Melbourne · DOI

Full title: Pharmaceutical process optimisation: Decision support under high uncertainty

Authors: Pham, TD; Manapragada, C; Rajan, N; Aickelin, U

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/324485

Thesis Characterization of the mechanism of action of spin-filters for animal cell perfusion cultures

Vallez-Chetreanu, Florentina · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Characterization of the mechanism of action of spin-filters for animal cell perfusion cultures

Authors: Vallez-Chetreanu, Florentina

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/224152

Thesis Response improvement in complex experiments by co-information composite likelihood optimization

Ferrari, D; Borrotti, M; De March, D · 2021 · University of Melbourne · DOI

Full title: Response improvement in complex experiments by co-information composite likelihood optimization

Authors: Ferrari, D; Borrotti, M; De March, D

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/282753

Thesis Development of an integrated platform for the production of recombinant biopharmaceuticals

Segarra, Camille · 2013 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Development of an integrated platform for the production of recombinant biopharmaceuticals

Authors: Segarra, Camille

Year: 2013

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/4147/1/Segarra_Thesis_PostCorrections.pdf

Thesis Capturing prediction uncertainty in upstream cell culture models using conformal prediction and Gaussian processes

Pham, TD; Aickelin, U; Bassett, R · 2024 · University of Melbourne · DOI

Full title: Capturing prediction uncertainty in upstream cell culture models using conformal prediction and Gaussian processes

Authors: Pham, TD; Aickelin, U; Bassett, R

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/339627

Thesis Optimal Bayesian design for model discrimination via classification

Hainy, M; Price, DJ; Restif, O et al. · 2022 · University of Melbourne · DOI

Full title: Optimal Bayesian design for model discrimination via classification

Authors: Hainy, M; Price, DJ; Restif, O; Drovandi, C

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/306676

Thesis Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture

Shariatzadeh, M; Lopes, AG; Glen, KE et al. · 2021 · University of Melbourne · DOI

Full title: Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture

Authors: Shariatzadeh, M; Lopes, AG; Glen, KE; Sinclair, A; Thomas, RJ

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/289743

Thesis Predictive models for upstream mammalian cell culture development: a review

Yatipanthalawa, BS; Gras, SL · 2023 · University of Melbourne · DOI

Full title: Predictive models for upstream mammalian cell culture development: a review

Authors: Yatipanthalawa, BS; Gras, SL

Year: 2023

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/339523

Thesis Application of mechanistic modelling in membrane and fiber chromatography for purification of biotherapeutics — A review

Qu, Y; Baker, I; Black, J et al. · 2024 · University of Melbourne · DOI

Full title: Application of mechanistic modelling in membrane and fiber chromatography for purification of biotherapeutics — A review

Authors: Qu, Y; Baker, I; Black, J; Fabri, L; Gras, SL; Lenhoff, AM; Kentish, SE

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/340258

Thesis A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments

Karimi Alavijeh, M; Lee, YY; Gras, SL · 2024 · University of Melbourne · DOI

Full title: A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments

Authors: Karimi Alavijeh, M; Lee, YY; Gras, SL

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/351093

Thesis Tools for digital twins in continuous downstream processing

Tallvod, Simon · 2023 · Lund University (LUP) · DOI

Full title: Tools for digital twins in continuous downstream processing

Authors: Tallvod, Simon

Year: 2023

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/191aa4b8-990d-47f1-a248-68bfb57ff330

Thesis A Model-based Approach to Evaluating Chromatography Capture Steps

Ulmestig, Jakob · 2017 · Lund University Student Papers · DOI

Full title: A Model-based Approach to Evaluating Chromatography Capture Steps

Authors: Ulmestig, Jakob

Year: 2017

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/8928249

Thesis Efficacy of robust regression applied to fractional factorial treatment structures.

McCants, Michael · 2011 · Kansas State University - K-REx · DOI

Full title: Efficacy of robust regression applied to fractional factorial treatment structures.

Authors: McCants, Michael

Year: 2011

Venue: Kansas State University - K-REx

DOI: http://hdl.handle.net/2097/9260

Thesis Design and Control of Integrated Continuous Processes for the Purification of Biopharmaceuticals

Gomis Fons, Joaquin · 2022 · Lund University (LUP) · DOI

Full title: Design and Control of Integrated Continuous Processes for the Purification of Biopharmaceuticals

Authors: Gomis Fons, Joaquin

Year: 2022

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/7de201f7-6a1b-4772-b3d1-e5d221e9515c

Thesis Digitalization in biopharmaceutical downstream processes

Espinoza, Daniel · 2024 · Lund University (LUP) · DOI

Full title: Digitalization in biopharmaceutical downstream processes

Authors: Espinoza, Daniel

Year: 2024

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/f936d3e3-244e-4f3b-812a-6866d82a1eee

Thesis Optimization of batch adsorption and fixed-bed adsorption of vanillin onto resin H103

Abu Samah, Rozaimi · 2016 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Optimization of batch adsorption and fixed-bed adsorption of vanillin onto resin H103

Authors: Abu Samah, Rozaimi

Year: 2016

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/112951/1/112951.pdf

Thesis Biomanufacturing of an organic solvent tolerant and thermostable lipase by recombinant E. coli

Nelofer, Rubina · 2012 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Biomanufacturing of an organic solvent tolerant and thermostable lipase by recombinant E. coli

Authors: Nelofer, Rubina

Year: 2012

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/33307/1/FBSB%202012%2019R.pdf

Thesis A MINE alternative to D-optimal designs for the linear model

Bouffier, Amanda Marie · 2024 · University of Georgia - UGA Open Scholar · DOI

Full title: A MINE alternative to D-optimal designs for the linear model

Authors: Bouffier, Amanda Marie

Year: 2024

Venue: University of Georgia - UGA Open Scholar

DOI: https://openscholar.uga.edu/record/20247/files/bouffier_amanda_m_201308_ms.pdf

Thesis Development of an integrated fermentation pervaporation model for bioethanol production

Hamid, Zentou · 2021 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Development of an integrated fermentation pervaporation model for bioethanol production

Authors: Hamid, Zentou

Year: 2021

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/98171/1/FK%202021%2087%20-%20IR.pdf

Thesis Optimization of a centrifugal electrospinning process using response surface methods and artificial neural networks

Greenawalt, Frank E., author; Duff, William S., advisor; Bradley, Thomas H., committee member et al. · 2007 · Colorado State University · DOI

Full title: Optimization of a centrifugal electrospinning process using response surface methods and artificial neural networks

Authors: Greenawalt, Frank E., author; Duff, William S., advisor; Bradley, Thomas H., committee member; Labadie, John W., committee member; Popat, Ketul C., committee member

Year: 2007

Venue: Colorado State University

DOI: http://hdl.handle.net/10217/82600

Thesis Optimal designs for generalized linear models

Tan, Xijue · 2024 · University of Georgia - UGA Open Scholar · DOI

Full title: Optimal designs for generalized linear models

Authors: Tan, Xijue

Year: 2024

Venue: University of Georgia - UGA Open Scholar

DOI: https://openscholar.uga.edu/record/12986/files/tan_xijue_201505_phd.pdf

Thesis Optimal Physical Experiments and Surrogates for Complex Computer Models

Jankar, Jeevan · 2025 · University of Georgia - UGA Open Scholar · DOI

Full title: Optimal Physical Experiments and Surrogates for Complex Computer Models

Authors: Jankar, Jeevan

Year: 2025

Venue: University of Georgia - UGA Open Scholar

DOI: https://openscholar.uga.edu/record/27335/files/Jankar_uga_0077E_16588.pdf

Thesis Systematic sequencing of factorial experiments as an alternative to the random order

Oprime, Pedro Carlos; Pureza, Vitória Maria Miranda; De Oliveira, Samuel Conceição [UNESP] · 2018 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Systematic sequencing of factorial experiments as an alternative to the random order

Authors: Oprime, Pedro Carlos; Pureza, Vitória Maria Miranda; De Oliveira, Samuel Conceição [UNESP]

Year: 2018

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1590/0104-530X1266-16

Thesis Fundamental concepts and recent applications of factorial statistical designs

Mainardi, Pedro Henrique [UNESP]; Bidoia, Ederio Dino [UNESP] · 2022 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Fundamental concepts and recent applications of factorial statistical designs

Authors: Mainardi, Pedro Henrique [UNESP]; Bidoia, Ederio Dino [UNESP]

Year: 2022

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://hdl.handle.net/11449/217478

Thesis Modelos estatísticos fatoriais: conceitos e aplicações

Mainardi, Pedro Henrique [UNESP]; Bidoia, Ederio Dino [UNESP] · 2021 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Modelos estatísticos fatoriais: conceitos e aplicações

Authors: Mainardi, Pedro Henrique [UNESP]; Bidoia, Ederio Dino [UNESP]

Year: 2021

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://hdl.handle.net/11449/214146

Thesis An application of sequential experimental design in catalyst kinetic studies

Agarwal, Anil K. (Anil Kumar) · 1994 · University of Sydney · DOI

Full title: An application of sequential experimental design in catalyst kinetic studies

Authors: Agarwal, Anil K. (Anil Kumar)

Year: 1994

Venue: University of Sydney

DOI: http://hdl.handle.net/2123/10235

Thesis Quality by design framework applied to GMMA purification

Giannelli, Carlo; Necchi, Francesca; Palmieri, Elena et al. · 2024 · Imperial College London · DOI

Full title: Quality by design framework applied to GMMA purification

Authors: Giannelli, Carlo; Necchi, Francesca; Palmieri, Elena; Oldrini, Davide; Ricchetti, Beatrice; Papathanasiou, Maria M; Kis, Zoltan; Kontoravdi, Cleo; Campa, Cristiana; Micoli, Francesca

Year: 2024

Venue: Imperial College London

DOI: https://link.springer.com/article/10.1208/s12248-024-00902-0

Thesis Discrete and mixed-variable experimental design with surrogate-based approach

Zhu, Mengjia; Mroz, Austin; Gui, Lingfeng et al. · 2024 · Imperial College London · DOI

Full title: Discrete and mixed-variable experimental design with surrogate-based approach

Authors: Zhu, Mengjia; Mroz, Austin; Gui, Lingfeng; Jelfs, Kim E; Bemporad, Alberto; del Río Chanona, Ehecatl Antonio; Lee, Ye Seol

Year: 2024

Venue: Imperial College London

DOI: http://dx.doi.org/10.1039/d4dd00113c

Thesis Bayesian Optimization with Dimension Scheduling: Application to Biological Systems

Ulmasov, D; Baroukh, C; Chachuat, B et al. · 2016 · Imperial College London · DOI

Full title: Bayesian Optimization with Dimension Scheduling: Application to Biological Systems

Authors: Ulmasov, D; Baroukh, C; Chachuat, B; Deisenroth, MP; Misener, R

Year: 2016

Venue: Imperial College London

DOI: http://arxiv.org/abs/1511.05385v1

Thesis Design of Experiments for Verifying Biomolecular Networks

Sedgwick, Ruby; Goertz, John; Stevens, Molly et al. · 2020 · Imperial College London · DOI

Full title: Design of Experiments for Verifying Biomolecular Networks

Authors: Sedgwick, Ruby; Goertz, John; Stevens, Molly; Misener, Ruth; Wilk, Mark van der

Year: 2020

Venue: Imperial College London

DOI: http://arxiv.org/abs/2011.10575v2

Thesis GPdoemd: a python package for design of experiments for model discrimination

Olofsson, Simon; Misener, Ruth · 2018 · Imperial College London · DOI

Full title: GPdoemd: a python package for design of experiments for model discrimination

Authors: Olofsson, Simon; Misener, Ruth

Year: 2018

Venue: Imperial College London

DOI: http://arxiv.org/abs/1810.02561v1

Thesis Safe real-time optimization using multi-fidelity guassian processes

Petsagkourakis, Panagiotis; Chachuat, Benoit; Rio-Chanona, Ehecatl Antonio del · 2022 · Imperial College London · DOI

Full title: Safe real-time optimization using multi-fidelity guassian processes

Authors: Petsagkourakis, Panagiotis; Chachuat, Benoit; Rio-Chanona, Ehecatl Antonio del

Year: 2022

Venue: Imperial College London

DOI: http://arxiv.org/abs/2111.05589v1

Thesis Bayesian hierarchical modelling of dual response surfaces

Chen, Younan · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Bayesian hierarchical modelling of dual response surfaces

Authors: Chen, Younan

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/29924

Thesis Bioprocess efficiency as a roadmap to establish Pichia pastoris as a reliable cell factory

Ponte Font, Xavier · 2017 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Bioprocess efficiency as a roadmap to establish Pichia pastoris as a reliable cell factory

Authors: Ponte Font, Xavier

Year: 2017

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/457712

Thesis Optimal Experimental Design for Poisson Impaired Reproduction Studies

Huffman, Jennifer Wade · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Optimal Experimental Design for Poisson Impaired Reproduction Studies

Authors: Huffman, Jennifer Wade

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/30751

Thesis Machine Learning and Multivariate Statistics for Optimizing Bioprocessing and Polyolefin Manufacturing

Agarwal, Aman · 2022 · Virginia Tech - VTechWorks · DOI

Full title: Machine Learning and Multivariate Statistics for Optimizing Bioprocessing and Polyolefin Manufacturing

Authors: Agarwal, Aman

Year: 2022

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/107480

Thesis Probabilistic framework for optimal experimental campaigns in the presence of operational constraints

Kusumo, Kennedy; Kuriyan, kamal; Vaidyaraman, Shankar et al. · 2022 · Imperial College London · DOI

Full title: Probabilistic framework for optimal experimental campaigns in the presence of operational constraints

Authors: Kusumo, Kennedy; Kuriyan, kamal; Vaidyaraman, Shankar; Garcia Munoz, Salvador; Shah, Nilay; Chachuat, Benoit

Year: 2022

Venue: Imperial College London

DOI: https://pubs.rsc.org/en/content/articlelanding/2022/RE/D1RE00465D

Thesis Neural Networks in Bioprocessing and Chemical Engineering

Baughman, D. Richard · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Neural Networks in Bioprocessing and Chemical Engineering

Authors: Baughman, D. Richard

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/29061

Thesis Data Driven Surrogate Based Optimization in the Problem Solving Environment WBCSim

Deshpande, Shubhangi · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Data Driven Surrogate Based Optimization in the Problem Solving Environment WBCSim

Authors: Deshpande, Shubhangi

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/35901

Thesis Bayesian Optimization for Engineering Design and Quality Control of Manufacturing Systems

AlBahar, Areej Ahmad · 2022 · Virginia Tech - VTechWorks · DOI

Full title: Bayesian Optimization for Engineering Design and Quality Control of Manufacturing Systems

Authors: AlBahar, Areej Ahmad

Year: 2022

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/109668

Thesis Bayesian D-Optimal Design for Generalized Linear Models

Zhang, Ying · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Bayesian D-Optimal Design for Generalized Linear Models

Authors: Zhang, Ying

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/30147

Thesis Adapting Response Surface Methods for the Optimization of Black-Box Systems

Zielinski, Jacob Jonathan · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Adapting Response Surface Methods for the Optimization of Black-Box Systems

Authors: Zielinski, Jacob Jonathan

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/39295

Thesis Enhancing the Functionality of a Microscale Bioreactor System as an Industrial Process Development Tool for Mammalian Perfusion Culture

Sewell, David J; Turner, Richard; Field, Ray et al. · 2019 · University of Cambridge · DOI

Full title: Enhancing the Functionality of a Microscale Bioreactor System as an Industrial Process Development Tool for Mammalian Perfusion Culture

Authors: Sewell, David J; Turner, Richard; Field, Ray; Holmes, William; Pradhan, Rahul; Spencer, Christopher; Oliver, Stephen; Slater, Nigel; Dikicioglu, Duygu

Year: 2019

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/289313

Thesis Data Analytics and Machine Learning Applications in Fermentation Processes and Molecular Property Prediction

Nguyen, Xuan Dung · 2025 · Virginia Tech - VTechWorks · DOI

Full title: Data Analytics and Machine Learning Applications in Fermentation Processes and Molecular Property Prediction

Authors: Nguyen, Xuan Dung

Year: 2025

Venue: Virginia Tech - VTechWorks

DOI: https://hdl.handle.net/10919/134219

Thesis Bayesian Two Stage Design Under Model Uncertainty

Neff, Angela R. · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Bayesian Two Stage Design Under Model Uncertainty

Authors: Neff, Angela R.

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/30303

Thesis Simulation and Comparison of Operational Modes in Simulated Moving Bed Chromatography and Gas-Phase Adsorptive Separation

Yu, Yueying · 2017 · Virginia Tech - VTechWorks · DOI

Full title: Simulation and Comparison of Operational Modes in Simulated Moving Bed Chromatography and Gas-Phase Adsorptive Separation

Authors: Yu, Yueying

Year: 2017

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/78319

Thesis General Weighted Optimality of Designed Experiments

Stallings, Jonathan W. · 2015 · Virginia Tech - VTechWorks · DOI

Full title: General Weighted Optimality of Designed Experiments

Authors: Stallings, Jonathan W.

Year: 2015

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/56949

Thesis Optimal experimental designs for two-variable logistic regression models

Jia, Yan · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Optimal experimental designs for two-variable logistic regression models

Authors: Jia, Yan

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/38044

Thesis Studies in process optimisation

Hiep, Luu Tien · 1972 · UNSW Sydney · DOI

Full title: Studies in process optimisation

Authors: Hiep, Luu Tien

Year: 1972

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/57733

Thesis Quantifying the maximum possible improvement in $$2^{k}$$ 2 k experiments

Sudarsanam, Nandan; Kumar, Anusha; Frey, Daniel D. · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Quantifying the maximum possible improvement in $$2^{k}$$ 2 k experiments

Authors: Sudarsanam, Nandan; Kumar, Anusha; Frey, Daniel D.

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/142959

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Metadata only

Paper Design of Experiment

Khan, Rehman M. · 2013 · DOI

Full title: Design of Experiment

Authors: Khan, Rehman M.

Year: 2013

DOI: https://doi.org/10.1002/9781118307502.ch10

Paper The use and importance of design of experiments (DOE) in process modelling in food science and technology

Granato, Daniel; Calado, Verônica · 2013 · DOI

Full title: The use and importance of design of experiments (DOE) in process modelling in food science and technology

Authors: Granato, Daniel; Calado, Verônica

Year: 2013

DOI: https://doi.org/10.1002/9781118434635.ch01

Paper Hydrogel Design of Experiments Methodology to Optimize Hydrogel for iPSC‐NPC Culture

Lam, Jonathan; Carmichael, S. Thomas; Lowry, William E. et al. · 2014 · Advanced Healthcare Materials · DOI

Full title: Hydrogel Design of Experiments Methodology to Optimize Hydrogel for iPSC‐NPC Culture

Authors: Lam, Jonathan; Carmichael, S. Thomas; Lowry, William E.; Segura, Tatiana

Year: 2014

Venue: Advanced Healthcare Materials

DOI: https://doi.org/10.1002/adhm.201400410

Paper Design of Experiments in Chemical Engineering

Lazić, Živorad R. · 2004 · DOI

Full title: Design of Experiments in Chemical Engineering

Authors: Lazić, Živorad R.

Year: 2004

DOI: https://doi.org/10.1002/3527604162

Paper The Impact of Culture Variables on a 3D Human In Vitro Bone Remodeling Model: A Design of Experiments Approach

B. W. de Wildt; L. Cuypers; E. Cramer et al. · 2023 · Advanced Healthcare Materials · DOI

Full title: The Impact of Culture Variables on a 3D Human In Vitro Bone Remodeling Model: A Design of Experiments Approach

Authors: B. W. de Wildt; L. Cuypers; E. Cramer; Annelieke S Wentzel; Keita Ito; S. Hofmann

Year: 2023

Venue: Advanced Healthcare Materials

DOI: https://doi.org/10.1002/adhm.202301205

Paper Pyomo.DOE : An open‐source package for model‐based design of experiments in Python

Wang, Jialu; Dowling, Alexander W. · 2022 · AIChE Journal · DOI

Full title: Pyomo.DOE : An open‐source package for model‐based design of experiments in Python

Authors: Wang, Jialu; Dowling, Alexander W.

Year: 2022

Venue: AIChE Journal

DOI: https://doi.org/10.1002/aic.17813

Paper Continuous precipitation of process related impurities from clarified cell culture supernatant using a novel coiled flow inversion reactor (CFIR).

Kateja, Nikhil; Agarwal, Harshit; Saraswat, Aditya et al. · 2016 · Biotechnology journal · DOI

Full title: Continuous precipitation of process related impurities from clarified cell culture supernatant using a novel coiled flow inversion reactor (CFIR).

Authors: Kateja, Nikhil; Agarwal, Harshit; Saraswat, Aditya; Bhat, Manish; Rathore, Anurag S

Year: 2016

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201600271

Paper Using prior parameter knowledge in model‐based design of experiments for pharmaceutical production

Shahmohammadi, Ali; McAuley, Kimberley B. · 2020 · AIChE Journal · DOI

Full title: Using prior parameter knowledge in model‐based design of experiments for pharmaceutical production

Authors: Shahmohammadi, Ali; McAuley, Kimberley B.

Year: 2020

Venue: AIChE Journal

DOI: https://doi.org/10.1002/aic.17021

Paper Advancing Cellular-Specific Delivery: Machine Learning Insights into Lipid Nanoparticles Design and Cellular Tropism.

Hanafy, Belal I; Munson, Michael J; Soundararajan, Ramesh et al. · 2025 · Advanced healthcare materials · DOI

Full title: Advancing Cellular-Specific Delivery: Machine Learning Insights into Lipid Nanoparticles Design and Cellular Tropism.

Authors: Hanafy, Belal I; Munson, Michael J; Soundararajan, Ramesh; Pereira, Sara; Gallud, Audrey; Sanaullah, Sajib Md; Carlesso, Gianluca; Mazza, Mariarosa

Year: 2025

Venue: Advanced healthcare materials

DOI: https://doi.org/10.1002/adhm.202500383

Paper High recovery of intracellular recombinant HBsAg from Pichia pastoris via continuous pulsed laser cell disruption system optimized by response surface methodology.

Gazor, Maryam; Ashraf Talesh, Seyed Siamak; Hosseini, Seyed Nezamedin et al. · 2019 · Biotechnology and applied biochemistry · DOI

Full title: High recovery of intracellular recombinant HBsAg from Pichia pastoris via continuous pulsed laser cell disruption system optimized by response surface methodology.

Authors: Gazor, Maryam; Ashraf Talesh, Seyed Siamak; Hosseini, Seyed Nezamedin; Javidanbardan, Amin; Khatami, Maryam

Year: 2019

Venue: Biotechnology and applied biochemistry

DOI: https://doi.org/10.1002/bab.1701

Paper An integrated scale-down plant for optimal recombinant enzyme production by Pichia pastoris.

Loegering, Kai; Mueller, Christian; Voss, Jan-Patrick et al. · 2011 · Biotechnology journal · DOI

Full title: An integrated scale-down plant for optimal recombinant enzyme production by Pichia pastoris.

Authors: Loegering, Kai; Mueller, Christian; Voss, Jan-Patrick; Wagenfuehrer, Claudia; Zahn, Daniel; Bertelsen, Hans-Peter; Scheffler, Ulrich; Luttmann, Reiner

Year: 2011

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201000384

Paper Recovery of Chinese hamster ovary host cell proteins for proteomic analysis.

Valente, Kristin N; Schaefer, Amy K; Kempton, Hannah R et al. · 2014 · Biotechnology journal · DOI

Full title: Recovery of Chinese hamster ovary host cell proteins for proteomic analysis.

Authors: Valente, Kristin N; Schaefer, Amy K; Kempton, Hannah R; Lenhoff, Abraham M; Lee, Kelvin H

Year: 2014

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201300190

Paper Optimization of thermophilic trans-isoprenyl diphosphate synthase expression in Escherichia coli by response surface methodology.

Piccolomini, Angelica A; Fiabon, Alex; Borrotti, Matteo et al. · 2017 · Biotechnology and applied biochemistry · DOI

Full title: Optimization of thermophilic trans-isoprenyl diphosphate synthase expression in Escherichia coli by response surface methodology.

Authors: Piccolomini, Angelica A; Fiabon, Alex; Borrotti, Matteo; De Lucrezia, Davide

Year: 2017

Venue: Biotechnology and applied biochemistry

DOI: https://doi.org/10.1002/bab.1459

Paper Comparison of Modeling Methods for DoE-Based Holistic Upstream Process Characterization.

Bayer, Benjamin; von Stosch, Moritz; Striedner, Gerald et al. · 2020 · Biotechnology journal · DOI

Full title: Comparison of Modeling Methods for DoE-Based Holistic Upstream Process Characterization.

Authors: Bayer, Benjamin; von Stosch, Moritz; Striedner, Gerald; Duerkop, Mark

Year: 2020

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201900551

Paper Hybrid Modeling and Intensified DoE: An Approach to Accelerate Upstream Process Characterization.

Bayer, Benjamin; Striedner, Gerald; Duerkop, Mark · 2020 · Biotechnology journal · DOI

Full title: Hybrid Modeling and Intensified DoE: An Approach to Accelerate Upstream Process Characterization.

Authors: Bayer, Benjamin; Striedner, Gerald; Duerkop, Mark

Year: 2020

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202000121

Paper Coping with complexity: machine learning optimization of cell-free protein synthesis.

Caschera, Filippo; Bedau, Mark A; Buchanan, Andrew et al. · 2011 · Biotechnology and bioengineering · DOI

Full title: Coping with complexity: machine learning optimization of cell-free protein synthesis.

Authors: Caschera, Filippo; Bedau, Mark A; Buchanan, Andrew; Cawse, James; de Lucrezia, Davide; Gazzola, Gianluca; Hanczyc, Martin M; Packard, Norman H

Year: 2011

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.23178

Paper Design of experiments reveals critical parameters for pilot-scale freeze-and-thaw processing of L-lactic dehydrogenase.

Roessl, Ulrich; Humi, Sebastian; Leitgeb, Stefan et al. · 2015 · Biotechnology journal · DOI

Full title: Design of experiments reveals critical parameters for pilot-scale freeze-and-thaw processing of L-lactic dehydrogenase.

Authors: Roessl, Ulrich; Humi, Sebastian; Leitgeb, Stefan; Nidetzky, Bernd

Year: 2015

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201400766

Paper Optimization of muscle cell culture media using nonlinear design of experiments.

Cosenza, Zachary; Block, David E; Baar, Keith · 2021 · Biotechnology journal · DOI

Full title: Optimization of muscle cell culture media using nonlinear design of experiments.

Authors: Cosenza, Zachary; Block, David E; Baar, Keith

Year: 2021

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202100228

Paper Reducing water uptake into BY-2 cells by systematically optimizing the cultivation parameters increases product yields achieved by transient expression in plant cell packs.

Opdensteinen, P; Buyel, J F · 2022 · Biotechnology journal · DOI

Full title: Reducing water uptake into BY-2 cells by systematically optimizing the cultivation parameters increases product yields achieved by transient expression in plant cell packs.

Authors: Opdensteinen, P; Buyel, J F

Year: 2022

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202200134

Paper Designing a fully automated multi-bioreactor plant for fast DoE optimization of pharmaceutical protein production.

Fricke, Jens; Pohlmann, Kristof; Jonescheit, Nils A et al. · 2013 · Biotechnology journal · DOI

Full title: Designing a fully automated multi-bioreactor plant for fast DoE optimization of pharmaceutical protein production.

Authors: Fricke, Jens; Pohlmann, Kristof; Jonescheit, Nils A; Ellert, Andree; Joksch, Burkhard; Luttmann, Reiner

Year: 2013

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201200190

Paper Defined Serum-Free Medium for Bioreactor Culture of an Immortalized Human Erythroblast Cell Line.

Lee, Esmond; Lim, Zhong Ri; Chen, Hong-Yu et al. · 2018 · Biotechnology journal · DOI

Full title: Defined Serum-Free Medium for Bioreactor Culture of an Immortalized Human Erythroblast Cell Line.

Authors: Lee, Esmond; Lim, Zhong Ri; Chen, Hong-Yu; Yang, Bin Xia; Lam, Alan Tin-Lun; Chen, Allen Kuan-Liang; Sivalingam, Jaichandran; Reuveny, Shaul; Loh, Yuin-Han; Oh, Steve Kah-Weng

Year: 2018

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201700567

Paper Simplex-based optimization of numerical and categorical inputs in early bioprocess development: Case studies in HT chromatography.

Konstantinidis, Spyridon; Titchener-Hooker, Nigel; Velayudhan, Ajoy · 2017 · Biotechnology journal · DOI

Full title: Simplex-based optimization of numerical and categorical inputs in early bioprocess development: Case studies in HT chromatography.

Authors: Konstantinidis, Spyridon; Titchener-Hooker, Nigel; Velayudhan, Ajoy

Year: 2017

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201700174

Paper Cellulose-based filter aids increase the capacity of depth filters during the downstream processing of plant-derived biopharmaceutical proteins.

Buyel, Johannes F; Opdensteinen, Patrick; Fischer, Rainer · 2015 · Biotechnology journal · DOI

Full title: Cellulose-based filter aids increase the capacity of depth filters during the downstream processing of plant-derived biopharmaceutical proteins.

Authors: Buyel, Johannes F; Opdensteinen, Patrick; Fischer, Rainer

Year: 2015

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201400611

Paper Identification of manipulated variables for a glycosylation control strategy.

St Amand, Melissa M; Radhakrishnan, Devesh; Robinson, Anne S et al. · 2014 · Biotechnology and bioengineering · DOI

Full title: Identification of manipulated variables for a glycosylation control strategy.

Authors: St Amand, Melissa M; Radhakrishnan, Devesh; Robinson, Anne S; Ogunnaike, Babatunde A

Year: 2014

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.25251

Paper Toward Machine Learning-Guided CHO Bioprocess and Media Optimization for Improved Titer and Glycosylation.

Walsh, Ian; Shozui, Fumi; Sato, Ayaka et al. · 2025 · Biotechnology journal · DOI

Full title: Toward Machine Learning-Guided CHO Bioprocess and Media Optimization for Improved Titer and Glycosylation.

Authors: Walsh, Ian; Shozui, Fumi; Sato, Ayaka; Park, Uiseon; Cho, Hyeran; Chia, Charmaine

Year: 2025

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.70149

Paper Optimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided by design of experiments.

Schwarz, Hubert; Lee, Kevin; Castan, Andreas et al. · 2023 · Biotechnology and bioengineering · DOI

Full title: Optimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided by design of experiments.

Authors: Schwarz, Hubert; Lee, Kevin; Castan, Andreas; Chotteau, Veronique

Year: 2023

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28397

Paper Identification of process conditions influencing protein aggregation in Chinese hamster ovary cell culture.

Paul, Albert J; Handrick, René; Ebert, Sybille et al. · 2018 · Biotechnology and bioengineering · DOI

Full title: Identification of process conditions influencing protein aggregation in Chinese hamster ovary cell culture.

Authors: Paul, Albert J; Handrick, René; Ebert, Sybille; Hesse, Friedemann

Year: 2018

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.26534

Paper Hyperthermic shift and cell engineering increase small extracellular vesicle production in HEK293F cells.

Keysberg, Christoph; Hertel, Oliver; Hoffrogge, Raimund et al. · 2024 · Biotechnology and bioengineering · DOI

Full title: Hyperthermic shift and cell engineering increase small extracellular vesicle production in HEK293F cells.

Authors: Keysberg, Christoph; Hertel, Oliver; Hoffrogge, Raimund; Reich, Sibylle; Hornung, Nadine; Holzmann, Karlheinz; Otte, Kerstin

Year: 2024

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28612

Paper Model-assisted process characterization and validation for a continuous two-column protein A capture process.

Baur, Daniel; Angelo, James; Chollangi, Srinivas et al. · 2019 · Biotechnology and bioengineering · DOI

Full title: Model-assisted process characterization and validation for a continuous two-column protein A capture process.

Authors: Baur, Daniel; Angelo, James; Chollangi, Srinivas; Müller-Späth, Thomas; Xu, Xuankuo; Ghose, Sanchayita; Li, Zheng Jian; Morbidelli, Massimo

Year: 2019

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.26849

Paper Advanced multivariate data analysis to determine the root cause of trisulfide bond formation in a novel antibody-peptide fusion.

Goldrick, Stephen; Holmes, William; Bond, Nicholas J et al. · 2017 · Biotechnology and bioengineering · DOI

Full title: Advanced multivariate data analysis to determine the root cause of trisulfide bond formation in a novel antibody-peptide fusion.

Authors: Goldrick, Stephen; Holmes, William; Bond, Nicholas J; Lewis, Gareth; Kuiper, Marcel; Turner, Richard; Farid, Suzanne S

Year: 2017

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.26339

Paper Rapid optimization of protein freeze‐drying formulations using ultra scale‐down and factorial design of experiment in microplates

Grant, Yitzchak; Matejtschuk, Paul; Dalby, Paul A. · 2009 · Biotechnology and Bioengineering · DOI

Full title: Rapid optimization of protein freeze‐drying formulations using ultra scale‐down and factorial design of experiment in microplates

Authors: Grant, Yitzchak; Matejtschuk, Paul; Dalby, Paul A.

Year: 2009

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.22448

Paper Defining process design space for monoclonal antibody cell culture.

Abu-Absi, Susan Fugett; Yang, LiYing; Thompson, Patrick et al. · 2010 · Biotechnology and bioengineering · DOI

Full title: Defining process design space for monoclonal antibody cell culture.

Authors: Abu-Absi, Susan Fugett; Yang, LiYing; Thompson, Patrick; Jiang, Canping; Kandula, Sunitha; Schilling, Bernhard; Shukla, Abhinav A

Year: 2010

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.22764

Paper CHO cell line specific prediction and control of recombinant monoclonal antibody N-glycosylation.

Grainger, Rhian K; James, David C · 2013 · Biotechnology and bioengineering · DOI

Full title: CHO cell line specific prediction and control of recombinant monoclonal antibody N-glycosylation.

Authors: Grainger, Rhian K; James, David C

Year: 2013

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.24959

Paper The simplex algorithm for the rapid identification of operating conditions during early bioprocess development: case studies in FAb' precipitation and multimodal chromatography.

Chhatre, Sunil; Konstantinidis, Spyridon; Ji, Yu et al. · 2011 · Biotechnology and bioengineering · DOI

Full title: The simplex algorithm for the rapid identification of operating conditions during early bioprocess development: case studies in FAb' precipitation and multimodal chromatography.

Authors: Chhatre, Sunil; Konstantinidis, Spyridon; Ji, Yu; Edwards-Parton, Simon; Zhou, Yuhong; Titchener-Hooker, Nigel J

Year: 2011

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.23151

Paper Addressing amino acid-derived inhibitory metabolites and enhancing CHO cell culture performance through DOE-guided media modifications.

Ladiwala, Pranay; Dhara, Venkata Gayatri; Jenkins, Jackson et al. · 2023 · Biotechnology and bioengineering · DOI

Full title: Addressing amino acid-derived inhibitory metabolites and enhancing CHO cell culture performance through DOE-guided media modifications.

Authors: Ladiwala, Pranay; Dhara, Venkata Gayatri; Jenkins, Jackson; Kuang, Bingyu; Hoang, Duc; Yoon, Seongkyu; Betenbaugh, Michael J

Year: 2023

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28403

Paper Red cell manufacturing using parallel stirred-tank bioreactors at the final stages of differentiation enhances reticulocyte maturation.

Han, So Yeon; Lee, Eun Mi; Lee, Janghan et al. · 2021 · Biotechnology and bioengineering · DOI

Full title: Red cell manufacturing using parallel stirred-tank bioreactors at the final stages of differentiation enhances reticulocyte maturation.

Authors: Han, So Yeon; Lee, Eun Mi; Lee, Janghan; Lee, Hyosang; Kwon, Amy M; Ryu, Ki Young; Choi, Won-Seok; Baek, Eun Jung

Year: 2021

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.27691

Paper Rational optimization of culture conditions for the most efficient ethanol production in Scheffersomyces stipitis using design of experiments.

Unrean, Pornkamol; Nguyen, Nhung H A · 2012 · Biotechnology progress · DOI

Full title: Rational optimization of culture conditions for the most efficient ethanol production in Scheffersomyces stipitis using design of experiments.

Authors: Unrean, Pornkamol; Nguyen, Nhung H A

Year: 2012

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.1595

Paper UHPLC Method Development for the Trace Level Quantification of Anastrozole and Its Process-Related Impurities Using Design of Experiments.

Tadisetty, Narasimha Rao; Yanamandra, Ramesh; Pradhan, Subhalaxmi et al. · 2026 · Biomedical chromatography : BMC · DOI

Full title: UHPLC Method Development for the Trace Level Quantification of Anastrozole and Its Process-Related Impurities Using Design of Experiments.

Authors: Tadisetty, Narasimha Rao; Yanamandra, Ramesh; Pradhan, Subhalaxmi; Pradhan, Gitanjali

Year: 2026

Venue: Biomedical chromatography : BMC

DOI: https://doi.org/10.1002/bmc.70279

Paper Design of transfections: Implementation of design of experiments for cell transfection fine tuning.

Mancinelli, Sara; Turcato, Andrea; Kisslinger, Annamaria et al. · 2021 · Biotechnology and bioengineering · DOI

Full title: Design of transfections: Implementation of design of experiments for cell transfection fine tuning.

Authors: Mancinelli, Sara; Turcato, Andrea; Kisslinger, Annamaria; Bongiovanni, Antonella; Zazzu, Valeria; Lanati, Antonella; Liguori, Giovanna Lucia

Year: 2021

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.27918

Paper Quality by design approach to improve quality and decrease cost of in vitro transcription of mRNA using design of experiments.

Boman, Jimmy; Marušič, Tjaša; Seravalli, Tina Vodopivec et al. · 2024 · Biotechnology and bioengineering · DOI

Full title: Quality by design approach to improve quality and decrease cost of in vitro transcription of mRNA using design of experiments.

Authors: Boman, Jimmy; Marušič, Tjaša; Seravalli, Tina Vodopivec; Skok, Janja; Pettersson, Fredrik; Nemec, Kristina Šprinzar; Widmark, Henrik; Sekirnik, Rok

Year: 2024

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28806

Paper Toward intensifying design of experiments in upstream bioprocess development: An industrial <i>Escherichia coli</i> feasibility study

Stosch, Moritz von; Hamelink, Jan‐Martijn; Oliveira, Rui · 2016 · Biotechnology Progress · DOI

Full title: Toward intensifying design of experiments in upstream bioprocess development: An industrial <i>Escherichia coli</i> feasibility study

Authors: Stosch, Moritz von; Hamelink, Jan‐Martijn; Oliveira, Rui

Year: 2016

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2295

Paper Design of experiments applications in bioprocessing: concepts and approach.

Kumar, Vijesh; Bhalla, Akriti; Rathore, Anurag S · 2014 · Biotechnology progress · DOI

Full title: Design of experiments applications in bioprocessing: concepts and approach.

Authors: Kumar, Vijesh; Bhalla, Akriti; Rathore, Anurag S

Year: 2014

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.1821

Paper Integrating Ensemble NSGA-II for Multi-Objective Process Optimization: Refolding of Proinsulin as a Case Study.

Sharma, Rashmi; Jesubalan, Naveen G; Rathore, Anurag S · 2026 · Biotechnology and bioengineering · DOI

Full title: Integrating Ensemble NSGA-II for Multi-Objective Process Optimization: Refolding of Proinsulin as a Case Study.

Authors: Sharma, Rashmi; Jesubalan, Naveen G; Rathore, Anurag S

Year: 2026

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.70119

Paper Combining mechanistic and data-driven approaches to gain process knowledge on the control of the metabolic shift to lactate uptake in a fed-batch CHO process.

Zalai, Dénes; Koczka, Krisztina; Párta, László et al. · 2015 · Biotechnology progress · DOI

Full title: Combining mechanistic and data-driven approaches to gain process knowledge on the control of the metabolic shift to lactate uptake in a fed-batch CHO process.

Authors: Zalai, Dénes; Koczka, Krisztina; Párta, László; Wechselberger, Patrick; Klein, Tobias; Herwig, Christoph

Year: 2015

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2179

Paper Effect of pH, NaCl concentration, and mAb concentration of feed solution on the filterability of Planova™ 20N and Planova™ BioEX.

Hashikawa-Muto, Chie; Yokoyama, Yoshiro; Hamamoto, Ryo et al. · 2024 · Biotechnology progress · DOI

Full title: Effect of pH, NaCl concentration, and mAb concentration of feed solution on the filterability of Planova™ 20N and Planova™ BioEX.

Authors: Hashikawa-Muto, Chie; Yokoyama, Yoshiro; Hamamoto, Ryo; Kobayashi, Kazuya; Masuda, Yumiko; Nonaka, Koichi

Year: 2024

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3420

Paper Application of simplex-based experimental optimization to challenging bioprocess development problems: Case studies in downstream processing.

Konstantinidis, Spyridon; Welsh, John P; Roush, David J et al. · 2016 · Biotechnology progress · DOI

Full title: Application of simplex-based experimental optimization to challenging bioprocess development problems: Case studies in downstream processing.

Authors: Konstantinidis, Spyridon; Welsh, John P; Roush, David J; Velayudhan, Ajoy

Year: 2016

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2234

Paper At-line raman spectroscopy and design of experiments for robust monitoring and control of miniature bioreactor cultures.

Rowland-Jones, Ruth C; Jaques, Colin · 2019 · Biotechnology progress · DOI

Full title: At-line raman spectroscopy and design of experiments for robust monitoring and control of miniature bioreactor cultures.

Authors: Rowland-Jones, Ruth C; Jaques, Colin

Year: 2019

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2740

Paper Optimization of a Saccharomyces cerevisiae fermentation process for production of a therapeutic recombinant protein using a multivariate Bayesian approach.

Fu, Zhibiao; Leighton, Julie; Cheng, Aili et al. · 2012 · Biotechnology progress · DOI

Full title: Optimization of a Saccharomyces cerevisiae fermentation process for production of a therapeutic recombinant protein using a multivariate Bayesian approach.

Authors: Fu, Zhibiao; Leighton, Julie; Cheng, Aili; Appelbaum, Edward; Aon, Juan C

Year: 2012

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.1557

Paper Statistical vs. stochastic experimental design: an experimental comparison on the example of protein refolding.

Anselment, Bernd; Schoemig, Veronika; Kesten, Christopher et al. · 2012 · Biotechnology progress · DOI

Full title: Statistical vs. stochastic experimental design: an experimental comparison on the example of protein refolding.

Authors: Anselment, Bernd; Schoemig, Veronika; Kesten, Christopher; Weuster-Botz, Dirk

Year: 2012

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.1635

Paper Efficient high-throughput biological process characterization: Definitive screening design with the ambr250 bioreactor system.

Tai, Mitchell; Ly, Amanda; Leung, Inne et al. · 2015 · Biotechnology progress · DOI

Full title: Efficient high-throughput biological process characterization: Definitive screening design with the ambr250 bioreactor system.

Authors: Tai, Mitchell; Ly, Amanda; Leung, Inne; Nayar, Gautam

Year: 2015

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2142

Paper Optimizing glutamine concentration enhances ex vivo expansion of natural killer cells through improved redox status.

Ying, Danni; Zhang, Guofeng; Huang, Huimin et al. · 2024 · Biotechnology progress · DOI

Full title: Optimizing glutamine concentration enhances ex vivo expansion of natural killer cells through improved redox status.

Authors: Ying, Danni; Zhang, Guofeng; Huang, Huimin; Tan, Wen-Song; Cai, Haibo

Year: 2024

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3464

Paper Data-driven multi-objective optimization via grid compatible simplex technique and desirability approach for challenging high throughput chromatography applications.

Konstantinidis, Spyridon; Welsh, John P; Titchener-Hooker, Nigel J et al. · 2018 · Biotechnology progress · DOI

Full title: Data-driven multi-objective optimization via grid compatible simplex technique and desirability approach for challenging high throughput chromatography applications.

Authors: Konstantinidis, Spyridon; Welsh, John P; Titchener-Hooker, Nigel J; Roush, David J; Velayudhan, Ajoy

Year: 2018

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2673

Paper Characterization of a Saccharomyces cerevisiae fermentation process for production of a therapeutic recombinant protein using a multivariate Bayesian approach.

Fu, Zhibiao; Baker, Daniel; Cheng, Aili et al. · 2016 · Biotechnology progress · DOI

Full title: Characterization of a Saccharomyces cerevisiae fermentation process for production of a therapeutic recombinant protein using a multivariate Bayesian approach.

Authors: Fu, Zhibiao; Baker, Daniel; Cheng, Aili; Leighton, Julie; Appelbaum, Edward; Aon, Juan

Year: 2016

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2264

Paper Efficient optimization of time-varying inputs in a fed-batch cell culture process using design of dynamic experiments.

Luo, Yu; Stanton, Duane A; Sharp, Rachel C et al. · 2023 · Biotechnology progress · DOI

Full title: Efficient optimization of time-varying inputs in a fed-batch cell culture process using design of dynamic experiments.

Authors: Luo, Yu; Stanton, Duane A; Sharp, Rachel C; Parrillo, Alexis J; Morgan, Kelsey T; Ritz, Diana B; Talwar, Sameer

Year: 2023

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3380

Paper Traces matter: Targeted optimization of monoclonal antibody N-glycosylation based on/by implementing automated high-throughput trace element screening.

Markert, Sven; Torkler, Stephanie; Hohmann, Katharina et al. · 2020 · Biotechnology progress · DOI

Full title: Traces matter: Targeted optimization of monoclonal antibody N-glycosylation based on/by implementing automated high-throughput trace element screening.

Authors: Markert, Sven; Torkler, Stephanie; Hohmann, Katharina; Popp, Oliver

Year: 2020

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3042

Paper Trace metal optimization in CHO cell culture through statistical design of experiments.

Polanco, Ashli; Liang, George; Park, SoYoung et al. · 2023 · Biotechnology progress · DOI

Full title: Trace metal optimization in CHO cell culture through statistical design of experiments.

Authors: Polanco, Ashli; Liang, George; Park, SoYoung; Wang, Yongdan; Graham, Ryan J; Yoon, Seongkyu

Year: 2023

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3368

Paper Crosslinked Aggregates of Fusion Enzymes in Microaqueous Organic Media.

Vernet, Guillem; Ma, Yu; Zhang, Ningning et al. · 2023 · Chembiochem : a European journal of chemical biology · DOI

Full title: Crosslinked Aggregates of Fusion Enzymes in Microaqueous Organic Media.

Authors: Vernet, Guillem; Ma, Yu; Zhang, Ningning; Kara, Selin

Year: 2023

Venue: Chembiochem : a European journal of chemical biology

DOI: https://doi.org/10.1002/cbic.202200794

Paper Design of experiments applications in bioprocessing: Chromatography process development using split design of experiments.

Shekhawat, Lalita K; Godara, Avinash; Kumar, Vijesh et al. · 2019 · Biotechnology progress · DOI

Full title: Design of experiments applications in bioprocessing: Chromatography process development using split design of experiments.

Authors: Shekhawat, Lalita K; Godara, Avinash; Kumar, Vijesh; Rathore, Anurag S

Year: 2019

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2730

Paper High-throughput screening techniques for rapid PEG-based precipitation of IgG4 mAb from clarified cell culture supernatant.

Knevelman, Carol; Davies, Jim; Allen, Lee et al. · 2010 · Biotechnology progress · DOI

Full title: High-throughput screening techniques for rapid PEG-based precipitation of IgG4 mAb from clarified cell culture supernatant.

Authors: Knevelman, Carol; Davies, Jim; Allen, Lee; Titchener-Hooker, Nigel J

Year: 2010

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.357

Paper Bioprocess optimization using design-of-experiments methodology.

Mandenius, Carl-Fredrik; Brundin, Anders · 2008 · Biotechnology progress · DOI

Full title: Bioprocess optimization using design-of-experiments methodology.

Authors: Mandenius, Carl-Fredrik; Brundin, Anders

Year: 2008

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.67

Paper Strategies for developing design spaces for viral clearance by anion exchange chromatography during monoclonal antibody production.

Strauss, Daniel M; Cano, Tony; Cai, Nick et al. · 2010 · Biotechnology progress · DOI

Full title: Strategies for developing design spaces for viral clearance by anion exchange chromatography during monoclonal antibody production.

Authors: Strauss, Daniel M; Cano, Tony; Cai, Nick; Delucchi, Heather; Plancarte, Magdalena; Coleman, Daniel; Blank, Gregory S; Chen, Qi; Yang, Bin

Year: 2010

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.385

Paper Reusing wastewater from Coffea arabica processing to produce single-cell protein using Candida sorboxylosa: Optimizing of culture conditions.

Pillaca-Pullo, Omar Santiago; Lopes, André Moreni; Estela-Escalante, Waldir D · 2024 · Biotechnology progress · DOI

Full title: Reusing wastewater from Coffea arabica processing to produce single-cell protein using Candida sorboxylosa: Optimizing of culture conditions.

Authors: Pillaca-Pullo, Omar Santiago; Lopes, André Moreni; Estela-Escalante, Waldir D

Year: 2024

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3393

Paper Enhancing the performance of an in vitro RNA biosensor through iterative design of experiments.

Aw, Rochelle; Polizzi, Karen · 2025 · Biotechnology progress · DOI

Full title: Enhancing the performance of an in vitro RNA biosensor through iterative design of experiments.

Authors: Aw, Rochelle; Polizzi, Karen

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.70005

Paper Tailoring Natural Solvents: Deep Eutectic Approach for Recovering Bioactives From Prunus spinosa L.

Bozkurt, Rabia Nur; Falsafi, Seid Reza; Şahin, Selin · 2025 · Chemistry & biodiversity · DOI

Full title: Tailoring Natural Solvents: Deep Eutectic Approach for Recovering Bioactives From Prunus spinosa L.

Authors: Bozkurt, Rabia Nur; Falsafi, Seid Reza; Şahin, Selin

Year: 2025

Venue: Chemistry & biodiversity

DOI: https://doi.org/10.1002/cbdv.202501858

Paper Downstream antibody purification using aqueous two-phase extraction.

Mao, Lisong Nathan; Rogers, Jameson K; Westoby, Matthew et al. · 2010 · Biotechnology progress · DOI

Full title: Downstream antibody purification using aqueous two-phase extraction.

Authors: Mao, Lisong Nathan; Rogers, Jameson K; Westoby, Matthew; Conley, Lynn; Pieracci, John

Year: 2010

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.477

Paper Statistical Design of Experiments for Screening and Optimization

Lee, Robert · 2019 · Chemie Ingenieur Technik · DOI

Full title: Statistical Design of Experiments for Screening and Optimization

Authors: Lee, Robert

Year: 2019

Venue: Chemie Ingenieur Technik

DOI: https://doi.org/10.1002/cite.201800100

Paper Cell line specific control of polyethylenimine-mediated transient transfection optimized with "Design of experiments" methodology.

Thompson, Ben C; Segarra, Camille R J; Mozley, Olivia L et al. · 2012 · Biotechnology progress · DOI

Full title: Cell line specific control of polyethylenimine-mediated transient transfection optimized with "Design of experiments" methodology.

Authors: Thompson, Ben C; Segarra, Camille R J; Mozley, Olivia L; Daramola, Olalekan; Field, Ray; Levison, Peter R; James, David C

Year: 2012

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.715

Paper Design of Experiments: A comparison study from the non‐expert user's perspective

Santos, Catarina Pereira; Rato, Tiago J.; Reis, Marco S. · 2018 · Journal of Chemometrics · DOI

Full title: Design of Experiments: A comparison study from the non‐expert user's perspective

Authors: Santos, Catarina Pereira; Rato, Tiago J.; Reis, Marco S.

Year: 2018

Venue: Journal of Chemometrics

DOI: https://doi.org/10.1002/cem.3087

Paper The design of experiments when there are errors in all the variables

Keeler, Scott E.; Reilly, Park M. · 1992 · The Canadian Journal of Chemical Engineering · DOI

Full title: The design of experiments when there are errors in all the variables

Authors: Keeler, Scott E.; Reilly, Park M.

Year: 1992

Venue: The Canadian Journal of Chemical Engineering

DOI: https://doi.org/10.1002/cjce.5450700422

Paper Optimization of EGFR high positive cell isolation procedure by design of experiments methodology.

Levi, Ofer; Tal, Baruch; Hileli, Sagi et al. · 2015 · Cytometry. Part B, Clinical cytometry · DOI

Full title: Optimization of EGFR high positive cell isolation procedure by design of experiments methodology.

Authors: Levi, Ofer; Tal, Baruch; Hileli, Sagi; Shapira, Assaf; Benhar, Itai; Grabov, Pavel; Eliaz, Noam

Year: 2015

Venue: Cytometry. Part B, Clinical cytometry

DOI: https://doi.org/10.1002/cyto.b.21246

Paper Guidelines for the optimal design of experiments to estimate parameters in first order kinetic models

Reilly, Park M.; Bajramovic, R.; Blau, Gary et al. · 1977 · The Canadian Journal of Chemical Engineering · DOI

Full title: Guidelines for the optimal design of experiments to estimate parameters in first order kinetic models

Authors: Reilly, Park M.; Bajramovic, R.; Blau, Gary; Branson, Dean R.; Sauerhoff, Mitchell W.

Year: 1977

Venue: The Canadian Journal of Chemical Engineering

DOI: https://doi.org/10.1002/cjce.5450550521

Paper Experimental design for the optimization and robustness testing of a liquid chromatography tandem mass spectrometry method for the trace analysis of the potentially genotoxic 1,3-diisopropylurea.

Székely, György; Henriques, Bruno; Gil, Marco et al. · 2014 · Drug testing and analysis · DOI

Full title: Experimental design for the optimization and robustness testing of a liquid chromatography tandem mass spectrometry method for the trace analysis of the potentially genotoxic 1,3-diisopropylurea.

Authors: Székely, György; Henriques, Bruno; Gil, Marco; Alvarez, Carlos

Year: 2014

Venue: Drug testing and analysis

DOI: https://doi.org/10.1002/dta.1583

Paper Treatment of Pulp Black Liquor with an Ionic Liquid: Modeling and Optimization by Using Response Surface Methodology and Central Composite Design.

Papaiconomou, Nicolas; Magnin, Jean-Pierre; Billard, Isabelle · 2023 · ChemPlusChem · DOI

Full title: Treatment of Pulp Black Liquor with an Ionic Liquid: Modeling and Optimization by Using Response Surface Methodology and Central Composite Design.

Authors: Papaiconomou, Nicolas; Magnin, Jean-Pierre; Billard, Isabelle

Year: 2023

Venue: ChemPlusChem

DOI: https://doi.org/10.1002/cplu.202200348

Paper Sustainability-Driven Accelerated Shear-Mediated Immunoassay for Amyotrophic Lateral Sclerosis Detection.

Luo, Xuan; Heydari, Amir; Renfrey, Danielle et al. · 2024 · ChemSusChem · DOI

Full title: Sustainability-Driven Accelerated Shear-Mediated Immunoassay for Amyotrophic Lateral Sclerosis Detection.

Authors: Luo, Xuan; Heydari, Amir; Renfrey, Danielle; Gardner, Zoe; He, Shan; Tang, Youhong; Weiss, Gregory A; Rogers, Mary-Louise; Raston, Colin L

Year: 2024

Venue: ChemSusChem

DOI: https://doi.org/10.1002/cssc.202401008

Paper Applying intensified design of experiments to mammalian cell culture processes.

Nold, Verena; Junghans, Lisa; Bisgen, Lorenzo et al. · 2022 · Engineering in life sciences · DOI

Full title: Applying intensified design of experiments to mammalian cell culture processes.

Authors: Nold, Verena; Junghans, Lisa; Bisgen, Lorenzo; Drerup, Raphael; Presser, Beate; Gorr, Ingo; Schwab, Thomas; Knapp, Bettina; Wieschalka, Stefan

Year: 2022

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.202100123

Paper Intensified design of experiments for upstream bioreactors.

von Stosch, Moritz; Willis, Mark J · 2017 · Engineering in life sciences · DOI

Full title: Intensified design of experiments for upstream bioreactors.

Authors: von Stosch, Moritz; Willis, Mark J

Year: 2017

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.201600037

Paper DoE-based validation of a HPLC-UV method for quantification of rotigotine nanocrystals: Application to in vitro dissolution and ex vivo nasal permeation studies.

Saha, Paramita; Pandey, Murali Monohar · 2022 · Electrophoresis · DOI

Full title: DoE-based validation of a HPLC-UV method for quantification of rotigotine nanocrystals: Application to in vitro dissolution and ex vivo nasal permeation studies.

Authors: Saha, Paramita; Pandey, Murali Monohar

Year: 2022

Venue: Electrophoresis

DOI: https://doi.org/10.1002/elps.202100157

Paper Design of experiments-based high-throughput strategy for development and optimization of efficient cell disruption protocols.

Glauche, Florian; Pilarek, Maciej; Bournazou, Mariano Nicolas Cruz et al. · 2017 · Engineering in life sciences · DOI

Full title: Design of experiments-based high-throughput strategy for development and optimization of efficient cell disruption protocols.

Authors: Glauche, Florian; Pilarek, Maciej; Bournazou, Mariano Nicolas Cruz; Grunzel, Petra; Neubauer, Peter

Year: 2017

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.201600030

Paper Lignocellulose Treatment Using a Flow-Through Variant of OrganoCat Process.

Schoofs, Leonie; Weidener, Dennis; Leitner, Walter et al. · 2025 · ChemSusChem · DOI

Full title: Lignocellulose Treatment Using a Flow-Through Variant of OrganoCat Process.

Authors: Schoofs, Leonie; Weidener, Dennis; Leitner, Walter; Klose, Holger; Grande, Philipp M

Year: 2025

Venue: ChemSusChem

DOI: https://doi.org/10.1002/cssc.202401063

Paper Employing QbD strategies to assess the impact of cell viability and density on the primary recovery of monoclonal antibodies.

Wohlenberg, Ole Jacob; Kortmann, Carlotta; Meyer, Katharina V et al. · 2023 · Engineering in life sciences · DOI

Full title: Employing QbD strategies to assess the impact of cell viability and density on the primary recovery of monoclonal antibodies.

Authors: Wohlenberg, Ole Jacob; Kortmann, Carlotta; Meyer, Katharina V; Scheper, Thomas; Solle, Dörte

Year: 2023

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.202200056

Paper Implementation of a design of experiments to study the influence of the background electrolyte on separation and detection in non-aqueous capillary electrophoresis-mass spectrometry.

Posch, Tjorben Nils; Müller, Alexander; Schulz, Wolfgang et al. · 2012 · Electrophoresis · DOI

Full title: Implementation of a design of experiments to study the influence of the background electrolyte on separation and detection in non-aqueous capillary electrophoresis-mass spectrometry.

Authors: Posch, Tjorben Nils; Müller, Alexander; Schulz, Wolfgang; Pütz, Michael; Huhn, Carolin

Year: 2012

Venue: Electrophoresis

DOI: https://doi.org/10.1002/elps.201100381

Paper Optimization of the enantioseparation of a diaryl-pyrazole sulfonamide derivative by capillary electrophoresis in a dual CD mode using experimental design.

Rogez-Florent, Tiphaine; Foulon, Catherine; Six, Perrine et al. · 2014 · Electrophoresis · DOI

Full title: Optimization of the enantioseparation of a diaryl-pyrazole sulfonamide derivative by capillary electrophoresis in a dual CD mode using experimental design.

Authors: Rogez-Florent, Tiphaine; Foulon, Catherine; Six, Perrine; Goossens, Laurence; Danel, Cécile; Goossens, Jean-François

Year: 2014

Venue: Electrophoresis

DOI: https://doi.org/10.1002/elps.201300639

Paper Optimizing selectivity of anion hydrophobic multimodal chromatography for purification of a single-chain variable fragment.

Sakhnini, Laila I; Pedersen, Anja K; León, Ileana Rodríguez et al. · 2019 · Engineering in life sciences · DOI

Full title: Optimizing selectivity of anion hydrophobic multimodal chromatography for purification of a single-chain variable fragment.

Authors: Sakhnini, Laila I; Pedersen, Anja K; León, Ileana Rodríguez; Greisen, Per J; Hansen, Jens Jacob; Vester-Christensen, Malene B; Bülow, Leif; Dainiak, Maria B

Year: 2019

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.201800207

Paper An improved high cell density cultivation-iHCDC-strategy for leucine auxotrophic Escherichia coli K12 ER2507.

Beckmann, Björn; Hohmann, Dorothea; Eickmeyer, Moritz et al. · 2017 · Engineering in life sciences · DOI

Full title: An improved high cell density cultivation-iHCDC-strategy for leucine auxotrophic Escherichia coli K12 ER2507.

Authors: Beckmann, Björn; Hohmann, Dorothea; Eickmeyer, Moritz; Bolz, Sarah; Brodhagen, Corinna; Derr, Petra; Sanders, Ernst A

Year: 2017

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.201700054

Paper Influenza A Virus Production Following Quality by Design Principles.

Zinnecker, Tilia; Thiele, Kristin; Schmidberger, Timo et al. · 2025 · Engineering in life sciences · DOI

Full title: Influenza A Virus Production Following Quality by Design Principles.

Authors: Zinnecker, Tilia; Thiele, Kristin; Schmidberger, Timo; Genzel, Yvonne; Reichl, Udo

Year: 2025

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.70027

Paper Towards electroenzymatic processes involving old yellow enzymes and mediated cofactor regeneration.

Tosstorff, Andreas; Kroner, Cora; Opperman, Diederik J et al. · 2017 · Engineering in life sciences · DOI

Full title: Towards electroenzymatic processes involving old yellow enzymes and mediated cofactor regeneration.

Authors: Tosstorff, Andreas; Kroner, Cora; Opperman, Diederik J; Hollmann, Frank; Holtmann, Dirk

Year: 2017

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.201600158

Paper Optimization of capillary zone electrophoresis for charge heterogeneity testing of biopharmaceuticals using enhanced method development principles.

Moritz, Bernd; Locatelli, Valentina; Niess, Michele et al. · 2017 · Electrophoresis · DOI

Full title: Optimization of capillary zone electrophoresis for charge heterogeneity testing of biopharmaceuticals using enhanced method development principles.

Authors: Moritz, Bernd; Locatelli, Valentina; Niess, Michele; Bathke, Andrea; Kiessig, Steffen; Entler, Barbara; Finkler, Christof; Wegele, Harald; Stracke, Jan

Year: 2017

Venue: Electrophoresis

DOI: https://doi.org/10.1002/elps.201700145

Paper Design of experiments for development and optimization of a liquid chromatography coupled to tandem mass spectrometry bioanalytical assay.

Thorsteinsdóttir, Unnur Arna; Thorsteinsdóttir, Margrét · 2021 · Journal of mass spectrometry : JMS · DOI

Full title: Design of experiments for development and optimization of a liquid chromatography coupled to tandem mass spectrometry bioanalytical assay.

Authors: Thorsteinsdóttir, Unnur Arna; Thorsteinsdóttir, Margrét

Year: 2021

Venue: Journal of mass spectrometry : JMS

DOI: https://doi.org/10.1002/jms.4727

Paper Optimizing Tissue-Engineered Periosteum Biochemical Cues to Hasten Bone Allograft Healing.

March, Alyson; Wu, Hao; Choe, Regine et al. · 2025 · Journal of biomedical materials research. Part A · DOI

Full title: Optimizing Tissue-Engineered Periosteum Biochemical Cues to Hasten Bone Allograft Healing.

Authors: March, Alyson; Wu, Hao; Choe, Regine; Benoit, Danielle S W

Year: 2025

Venue: Journal of biomedical materials research. Part A

DOI: https://doi.org/10.1002/jbm.a.37890

Paper Bioreactor process parameter screening utilizing a Plackett-Burman design for a model monoclonal antibody.

Agarabi, Cyrus D; Schiel, John E; Lute, Scott C et al. · 2015 · Journal of pharmaceutical sciences · DOI

Full title: Bioreactor process parameter screening utilizing a Plackett-Burman design for a model monoclonal antibody.

Authors: Agarabi, Cyrus D; Schiel, John E; Lute, Scott C; Chavez, Brittany K; Boyne, Michael T; Brorson, Kurt A; Khan, Mansoora; Read, Erik K

Year: 2015

Venue: Journal of pharmaceutical sciences

DOI: https://doi.org/10.1002/jps.24420

Paper Investigating thiol-modification on hyaluronan via carbodiimide chemistry using response surface methodology.

Santhanam, Sruthi; Liang, Jue; Baid, Rinku et al. · 2015 · Journal of biomedical materials research. Part A · DOI

Full title: Investigating thiol-modification on hyaluronan via carbodiimide chemistry using response surface methodology.

Authors: Santhanam, Sruthi; Liang, Jue; Baid, Rinku; Ravi, Nathan

Year: 2015

Venue: Journal of biomedical materials research. Part A

DOI: https://doi.org/10.1002/jbm.a.35366

Paper Optimization of laccase production by Pleurotus ostreatus IMI 395545 using the Taguchi DOE methodology.

Periasamy, Rathinasamy; Palvannan, Thayumanavan · 2010 · Journal of basic microbiology · DOI

Full title: Optimization of laccase production by Pleurotus ostreatus IMI 395545 using the Taguchi DOE methodology.

Authors: Periasamy, Rathinasamy; Palvannan, Thayumanavan

Year: 2010

Venue: Journal of basic microbiology

DOI: https://doi.org/10.1002/jobm.201000095

Paper Determination of the clean-up efficiency of the solid-phase extraction of rosemary extracts: Application of full-factorial design in hyphenation with Gaussian peak fit function.

Meischl, Florian; Kirchler, Christian Günter; Jäger, Michael Andreas et al. · 2018 · Journal of separation science · DOI

Full title: Determination of the clean-up efficiency of the solid-phase extraction of rosemary extracts: Application of full-factorial design in hyphenation with Gaussian peak fit function.

Authors: Meischl, Florian; Kirchler, Christian Günter; Jäger, Michael Andreas; Huck, Christian Wolfgang; Rainer, Matthias

Year: 2018

Venue: Journal of separation science

DOI: https://doi.org/10.1002/jssc.201701008

Paper HPLC-electrospray ionization-mass spectrometry optimization by high-performance design of experiments for astrocyte glutamine measurement.

Bheemanapally, Khaggeswar; Ibrahim, Mostafa M H; Briski, Karen P · 2021 · Journal of mass spectrometry : JMS · DOI

Full title: HPLC-electrospray ionization-mass spectrometry optimization by high-performance design of experiments for astrocyte glutamine measurement.

Authors: Bheemanapally, Khaggeswar; Ibrahim, Mostafa M H; Briski, Karen P

Year: 2021

Venue: Journal of mass spectrometry : JMS

DOI: https://doi.org/10.1002/jms.4680

Paper Evaluation of Analytical Quality by Design Approaches on the Development and Optimization of Size Exclusion Chromatography Analytical Procedures for Bovine Serum Albumin.

Gaggero, Alessio; Jeremic, Dalibor; Sattler, Reingard et al. · 2025 · Journal of separation science · DOI

Full title: Evaluation of Analytical Quality by Design Approaches on the Development and Optimization of Size Exclusion Chromatography Analytical Procedures for Bovine Serum Albumin.

Authors: Gaggero, Alessio; Jeremic, Dalibor; Sattler, Reingard; Paudel, Amrit; Afonso Urich, Jesús Alberto

Year: 2025

Venue: Journal of separation science

DOI: https://doi.org/10.1002/jssc.70168

Paper An algorithm for fast optimal Latin hypercube design of experiments

Viana, Felipe; Venter, Gerhard; Balabanov, Vladimir · 2009 · International Journal for Numerical Methods in Engineering · DOI

Full title: An algorithm for fast optimal Latin hypercube design of experiments

Authors: Viana, Felipe; Venter, Gerhard; Balabanov, Vladimir

Year: 2009

Venue: International Journal for Numerical Methods in Engineering

DOI: https://doi.org/10.1002/nme.2750

Paper Biotechnological Control of Hydrogel Properties via Recombinant Protein Molecular Weight Engineering.

Schlauch, Domenic; Ebbecke, Jan Peter; von Alwörden, Amelie Paula et al. · 2026 · Macromolecular bioscience · DOI

Full title: Biotechnological Control of Hydrogel Properties via Recombinant Protein Molecular Weight Engineering.

Authors: Schlauch, Domenic; Ebbecke, Jan Peter; von Alwörden, Amelie Paula; Solle, Dörte; Kara, Selin; Lavrentieva, Antonina; Pepelanova, Iliyana

Year: 2026

Venue: Macromolecular bioscience

DOI: https://doi.org/10.1002/mabi.202500575

Paper Dual-Template Imprinted Polyaniline Designed by Response Surface Methodology.

Gorlo, V D; Pidenko, P S; Burmistrova, N A · 2025 · Journal of separation science · DOI

Full title: Dual-Template Imprinted Polyaniline Designed by Response Surface Methodology.

Authors: Gorlo, V D; Pidenko, P S; Burmistrova, N A

Year: 2025

Venue: Journal of separation science

DOI: https://doi.org/10.1002/jssc.70091

Paper Design of experiments approach for systematic optimization of a single-shot diaPASEF plasma proteomics workflow applicable for high-throughput.

Rice, Shawn J; Belani, Chandra P · 2024 · Proteomics. Clinical applications · DOI

Full title: Design of experiments approach for systematic optimization of a single-shot diaPASEF plasma proteomics workflow applicable for high-throughput.

Authors: Rice, Shawn J; Belani, Chandra P

Year: 2024

Venue: Proteomics. Clinical applications

DOI: https://doi.org/10.1002/prca.202300006

Paper Automated statistical experimental design approach for rapid separation of coenzyme Q10 and identification of its biotechnological process related impurities using UHPLC and UHPLC-APCI-MS.

Talluri, Murali V N Kumar; Kalariya, Pradipbhai D; Dharavath, Shireesha et al. · 2016 · Journal of separation science · DOI

Full title: Automated statistical experimental design approach for rapid separation of coenzyme Q10 and identification of its biotechnological process related impurities using UHPLC and UHPLC-APCI-MS.

Authors: Talluri, Murali V N Kumar; Kalariya, Pradipbhai D; Dharavath, Shireesha; Shaikh, Naeem; Garg, Prabha; Ramisetti, Nageswara Rao; Ragampeta, Srinivas

Year: 2016

Venue: Journal of separation science

DOI: https://doi.org/10.1002/jssc.201501405

Paper Development of a fluid bed granulation design space using critical quality attribute weighted tolerance intervals.

Zacour, Brian M; Drennen, James K; Anderson, Carl A · 2012 · Journal of pharmaceutical sciences · DOI

Full title: Development of a fluid bed granulation design space using critical quality attribute weighted tolerance intervals.

Authors: Zacour, Brian M; Drennen, James K; Anderson, Carl A

Year: 2012

Venue: Journal of pharmaceutical sciences

DOI: https://doi.org/10.1002/jps.23185

Paper Enrichment of Kaempferol-3-O-Sophoroside From Saffron Petals Using Macroporous Resin: Static Adsorption Characteristics and Dynamic Optimization Based on Analytical Hierarchy Process-Entropy Weight Method-Response Surface Methodology.

Xinyi Huo; Liling Wang; Lele Li et al. · 2025 · Journal of Separation Science · DOI

Full title: Enrichment of Kaempferol-3-O-Sophoroside From Saffron Petals Using Macroporous Resin: Static Adsorption Characteristics and Dynamic Optimization Based on Analytical Hierarchy Process-Entropy Weight Method-Response Surface Methodology.

Authors: Xinyi Huo; Liling Wang; Lele Li; Wanyan Zhu; Qilin Xu; Xiaohan Zhao; Xianggang Yin; Linlin Wu; Yifeng Zhou; Jun Huang

Year: 2025

Venue: Journal of Separation Science

DOI: https://doi.org/10.1002/jssc.70307

Paper Sensitivity analysis and optimization of system dynamics models: Regression analysis and statistical design of experiments

Kleijnen, J.P.C. · 1995 · System Dynamics Review · DOI

Full title: Sensitivity analysis and optimization of system dynamics models: Regression analysis and statistical design of experiments

Authors: Kleijnen, J.P.C.

Year: 1995

Venue: System Dynamics Review

DOI: https://doi.org/10.1002/sdr.4260110403

Paper Machine learning and Design of Experiments: Alternative approaches or complementary methodologies for quality improvement?

Freiesleben, Johannes; Keim, Jan; Grutsch, Markus · 2020 · Quality and Reliability Engineering International · DOI

Full title: Machine learning and Design of Experiments: Alternative approaches or complementary methodologies for quality improvement?

Authors: Freiesleben, Johannes; Keim, Jan; Grutsch, Markus

Year: 2020

Venue: Quality and Reliability Engineering International

DOI: https://doi.org/10.1002/qre.2579

Paper Robust parameter design of human induced pluripotent stem cell differentiation protocols defines lineage-specific induction of anterior-posterior gut tube endodermal cells.

Yasui, Ryota; Sekine, Keisuke; Yamaguchi, Kiyoshi et al. · 2021 · Stem cells (Dayton, Ohio) · DOI

Full title: Robust parameter design of human induced pluripotent stem cell differentiation protocols defines lineage-specific induction of anterior-posterior gut tube endodermal cells.

Authors: Yasui, Ryota; Sekine, Keisuke; Yamaguchi, Kiyoshi; Furukawa, Yoichi; Taniguchi, Hideki

Year: 2021

Venue: Stem cells (Dayton, Ohio)

DOI: https://doi.org/10.1002/stem.3326

Paper Human prorenin determination by hybrid immunocapture liquid chromatography/mass spectrometry: A mixed-solvent-triggered digestion utilizing D-optimal design.

Burdman, Ilja; Burckhardt, Bjoern B · 2020 · Rapid communications in mass spectrometry : RCM · DOI

Full title: Human prorenin determination by hybrid immunocapture liquid chromatography/mass spectrometry: A mixed-solvent-triggered digestion utilizing D-optimal design.

Authors: Burdman, Ilja; Burckhardt, Bjoern B

Year: 2020

Venue: Rapid communications in mass spectrometry : RCM

DOI: https://doi.org/10.1002/rcm.8932

Paper Improving waste activated sludge dewaterability with sodium periodate pre‐oxidation on extracellular polymeric substances

Bingbing Lan; Ruofei Jin; Guangfei Liu et al. · 2021 · Water environment research · DOI

Full title: Improving waste activated sludge dewaterability with sodium periodate pre‐oxidation on extracellular polymeric substances

Authors: Bingbing Lan; Ruofei Jin; Guangfei Liu; Bin Dong; Ji-ti Zhou; D. Xing

Year: 2021

Venue: Water environment research

DOI: https://doi.org/10.1002/wer.1553

Paper I-Optimal design of poly(lactic-co-glycolic) acid/hydroxyapatite three-dimensional scaffolds produced by thermally induced phase separation.

Liu, Junyi; Zhang, Jing; James, Paul F et al. · 2019 · Polymer engineering and science · DOI

Full title: I-Optimal design of poly(lactic-co-glycolic) acid/hydroxyapatite three-dimensional scaffolds produced by thermally induced phase separation.

Authors: Liu, Junyi; Zhang, Jing; James, Paul F; Yousefi, Azizeh-Mitra

Year: 2019

Venue: Polymer engineering and science

DOI: https://doi.org/10.1002/pen.25094

Paper Strategies for sequential design of experiments and augmentation

Lu, Lu; Anderson‐Cook, Christine M. · 2020 · Quality and Reliability Engineering International · DOI

Full title: Strategies for sequential design of experiments and augmentation

Authors: Lu, Lu; Anderson‐Cook, Christine M.

Year: 2020

Venue: Quality and Reliability Engineering International

DOI: https://doi.org/10.1002/qre.2823

Paper Downstream Processing Technologies/Capturing and Final Purification : Opportunities for Innovation, Change, and Improvement. A Review of Downstream Processing Developments in Protein Purification.

Singh, Nripen; Herzer, Sibylle · 2018 · Advances in biochemical engineering/biotechnology · DOI

Full title: Downstream Processing Technologies/Capturing and Final Purification : Opportunities for Innovation, Change, and Improvement. A Review of Downstream Processing Developments in Protein Purification.

Authors: Singh, Nripen; Herzer, Sibylle

Year: 2018

Venue: Advances in biochemical engineering/biotechnology

DOI: https://doi.org/10.1007/10_2017_12

Paper Efficient Optimization of Process Strategies with Model-Assisted Design of Experiments.

Kuchemüller, Kim B; Pörtner, Ralf; Möller, Johannes · 2020 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Efficient Optimization of Process Strategies with Model-Assisted Design of Experiments.

Authors: Kuchemüller, Kim B; Pörtner, Ralf; Möller, Johannes

Year: 2020

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-0716-0191-4_13

Paper Yarrowia lipolytica Bioprocess Development: From Flask to Bioreactor.

Darvishi, Farshad; Moradi, Marzieh · 2021 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Yarrowia lipolytica Bioprocess Development: From Flask to Bioreactor.

Authors: Darvishi, Farshad; Moradi, Marzieh

Year: 2021

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-0716-1414-3_15

Paper Multifactorial Experimental Design to Optimize the Anti-Inflammatory and Proangiogenic Potential of Mesenchymal Stem Cell Spheroids.

Murphy, Kaitlin C; Whitehead, Jacklyn; Falahee, Patrick C et al. · 2017 · Stem cells (Dayton, Ohio) · DOI

Full title: Multifactorial Experimental Design to Optimize the Anti-Inflammatory and Proangiogenic Potential of Mesenchymal Stem Cell Spheroids.

Authors: Murphy, Kaitlin C; Whitehead, Jacklyn; Falahee, Patrick C; Zhou, Dejie; Simon, Scott I; Leach, J Kent

Year: 2017

Venue: Stem cells (Dayton, Ohio)

DOI: https://doi.org/10.1002/stem.2606

Paper Step-By-Step Standardization of the Bottom-Up Semi-Automated Nanocrystallization of Pharmaceuticals: A Quality By Design and Design of Experiments Joint Approach.

Castillo Henríquez, Luis; Bahloul, Badr; Alhareth, Khair et al. · 2024 · Small (Weinheim an der Bergstrasse, Germany) · DOI

Full title: Step-By-Step Standardization of the Bottom-Up Semi-Automated Nanocrystallization of Pharmaceuticals: A Quality By Design and Design of Experiments Joint Approach.

Authors: Castillo Henríquez, Luis; Bahloul, Badr; Alhareth, Khair; Oyoun, Feras; Frejková, Markéta; Kostka, Libor; Etrych, Tomáš; Kalshoven, Luc; Guillaume, Alain; Mignet, Nathalie; Corvis, Yohann

Year: 2024

Venue: Small (Weinheim an der Bergstrasse, Germany)

DOI: https://doi.org/10.1002/smll.202306054

Paper Model‐based design of experiments for cellular processes

Chakrabarty, Ankush; Buzzard, Gregery T.; Rundell, Ann E. · 2013 · WIREs Systems Biology and Medicine · DOI

Full title: Model‐based design of experiments for cellular processes

Authors: Chakrabarty, Ankush; Buzzard, Gregery T.; Rundell, Ann E.

Year: 2013

Venue: WIREs Systems Biology and Medicine

DOI: https://doi.org/10.1002/wsbm.1204

Paper Microplate-Based Method for High-Throughput Screening (HTS) of Chromatographic Conditions Studies for Recombinant Protein Purification.

Carvalho, Rimenys J; Cruz, Thayana A · 2018 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Microplate-Based Method for High-Throughput Screening (HTS) of Chromatographic Conditions Studies for Recombinant Protein Purification.

Authors: Carvalho, Rimenys J; Cruz, Thayana A

Year: 2018

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-4939-7312-5_17

Paper Fractional Factorial Designs: An Underutilized Tool for Rapid In Vitro System Development.

Niedz, Randall P · 2021 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Fractional Factorial Designs: An Underutilized Tool for Rapid In Vitro System Development.

Authors: Niedz, Randall P

Year: 2021

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-0716-1331-3_2

Paper Digital Twins and Their Role in Model-Assisted Design of Experiments.

Kuchemüller, Kim B; Pörtner, Ralf; Möller, Johannes · 2021 · Advances in biochemical engineering/biotechnology · DOI

Full title: Digital Twins and Their Role in Model-Assisted Design of Experiments.

Authors: Kuchemüller, Kim B; Pörtner, Ralf; Möller, Johannes

Year: 2021

Venue: Advances in biochemical engineering/biotechnology

DOI: https://doi.org/10.1007/10_2020_136

Paper High-Throughput Process Development: II-Membrane Chromatography.

Rathore, Anurag S; Muthukumar, S · 2021 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: High-Throughput Process Development: II-Membrane Chromatography.

Authors: Rathore, Anurag S; Muthukumar, S

Year: 2021

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-0716-0775-6_3

Paper Medium optimization of antifungal lipopeptide, iturin A, production by Bacillus subtilis in solid-state fermentation by response surface methodology.

Mizumoto, Shinji; Shoda, Makoto · 2007 · Applied microbiology and biotechnology · DOI

Full title: Medium optimization of antifungal lipopeptide, iturin A, production by Bacillus subtilis in solid-state fermentation by response surface methodology.

Authors: Mizumoto, Shinji; Shoda, Makoto

Year: 2007

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-007-0994-9

Paper Design of experiments, a powerful tool for method development in forensic toxicology: application to the optimization of urinary morphine 3-glucuronide acid hydrolysis.

Costa, S; Barroso, M; Castañera, A et al. · 2010 · Analytical and bioanalytical chemistry · DOI

Full title: Design of experiments, a powerful tool for method development in forensic toxicology: application to the optimization of urinary morphine 3-glucuronide acid hydrolysis.

Authors: Costa, S; Barroso, M; Castañera, A; Dias, M

Year: 2010

Venue: Analytical and bioanalytical chemistry

DOI: https://doi.org/10.1007/s00216-009-3447-8

Paper Simultaneous detection of nicotinamide adenine nucleotides and adenylate pool to quantify redox and energy states in mAb-producing CHO cells by capillary electrophoresis.

Wang, Jiaqi; Wang, Chen; Fan, Li et al. · 2019 · Analytical and bioanalytical chemistry · DOI

Full title: Simultaneous detection of nicotinamide adenine nucleotides and adenylate pool to quantify redox and energy states in mAb-producing CHO cells by capillary electrophoresis.

Authors: Wang, Jiaqi; Wang, Chen; Fan, Li; Zhao, Liang; Tan, Wen-Song

Year: 2019

Venue: Analytical and bioanalytical chemistry

DOI: https://doi.org/10.1007/s00216-019-01747-9

Paper Xylanase recovery. Effect of extraction conditions on the aqueous two-phase system using experimental design.

Costa, S A; Pessoa, A; Roberto, I C · 1998 · Applied biochemistry and biotechnology · DOI

Full title: Xylanase recovery. Effect of extraction conditions on the aqueous two-phase system using experimental design.

Authors: Costa, S A; Pessoa, A; Roberto, I C

Year: 1998

Venue: Applied biochemistry and biotechnology

DOI: https://doi.org/10.1007/BF02920174

Paper Optimisation of electrochemical sensors based on molecularly imprinted polymers: from OFAT to machine learning.

Di Masi, Sabrina; De Benedetto, Giuseppe Egidio; Malitesta, Cosimino · 2024 · Analytical and bioanalytical chemistry · DOI

Full title: Optimisation of electrochemical sensors based on molecularly imprinted polymers: from OFAT to machine learning.

Authors: Di Masi, Sabrina; De Benedetto, Giuseppe Egidio; Malitesta, Cosimino

Year: 2024

Venue: Analytical and bioanalytical chemistry

DOI: https://doi.org/10.1007/s00216-023-05085-9

Paper Optimization and modeling of phenanthrene degradation by Mycobacterium sp. 6PY1 in a biphasic medium using response-surface methodology.

Abdelhay, Arwa; Magnin, Jean-Pierre; Gondrexon, Nicolas et al. · 2008 · Applied microbiology and biotechnology · DOI

Full title: Optimization and modeling of phenanthrene degradation by Mycobacterium sp. 6PY1 in a biphasic medium using response-surface methodology.

Authors: Abdelhay, Arwa; Magnin, Jean-Pierre; Gondrexon, Nicolas; Baup, Stéphane; Willison, John

Year: 2008

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-008-1365-x

Paper Optimisation of media and cultivation conditions for L(+)(S)-lactic acid production by Lactobacillus casei NRRL B-441.

Hujanen, M; Linko, S; Linko, Y Y et al. · 2001 · Applied microbiology and biotechnology · DOI

Full title: Optimisation of media and cultivation conditions for L(+)(S)-lactic acid production by Lactobacillus casei NRRL B-441.

Authors: Hujanen, M; Linko, S; Linko, Y Y; Leisola, M

Year: 2001

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s002530000501

Paper Overcoming hydrolysis of raw corn starch under industrial conditions with Bacillus licheniformis ATCC 9945a α-amylase.

Šokarda Slavić, Marinela; Pešić, Milja; Vujčić, Zoran et al. · 2016 · Applied microbiology and biotechnology · DOI

Full title: Overcoming hydrolysis of raw corn starch under industrial conditions with Bacillus licheniformis ATCC 9945a α-amylase.

Authors: Šokarda Slavić, Marinela; Pešić, Milja; Vujčić, Zoran; Božić, Nataša

Year: 2016

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-015-7101-4

Paper The importance of factorial design on the optimization of biosensor performance: immobilization of glucose oxidase as a case study.

Reséndiz-Jaramillo, A Y; Mendoza-Camargo, A P; Ortiz-Contreras, O E et al. · 2024 · Analytical and bioanalytical chemistry · DOI

Full title: The importance of factorial design on the optimization of biosensor performance: immobilization of glucose oxidase as a case study.

Authors: Reséndiz-Jaramillo, A Y; Mendoza-Camargo, A P; Ortiz-Contreras, O E; Rodríguez-Morales, J A; Huerta-Manzanilla, Eric L; Escalona-Villalpando, Ricardo A; Ledesma-García, J

Year: 2024

Venue: Analytical and bioanalytical chemistry

DOI: https://doi.org/10.1007/s00216-024-05582-5

Paper Rapid direct analysis in real time (DART) mass spectrometric detection of juvenile hormone III and its terpene precursors.

Navare, Arti T; Mayoral, Jaime G; Nouzova, Marcela et al. · 2010 · Analytical and bioanalytical chemistry · DOI

Full title: Rapid direct analysis in real time (DART) mass spectrometric detection of juvenile hormone III and its terpene precursors.

Authors: Navare, Arti T; Mayoral, Jaime G; Nouzova, Marcela; Noriega, Fernando G; Fernández, Facundo M

Year: 2010

Venue: Analytical and bioanalytical chemistry

DOI: https://doi.org/10.1007/s00216-010-4269-4

Paper Critical factors for the replication of mumps virus in primary chicken embryo fibroblasts defined by the use of design of experiments (DoE).

Markusic, Maja; Pavlović, Nediljko; Santak, Maja et al. · 2013 · Applied microbiology and biotechnology · DOI

Full title: Critical factors for the replication of mumps virus in primary chicken embryo fibroblasts defined by the use of design of experiments (DoE).

Authors: Markusic, Maja; Pavlović, Nediljko; Santak, Maja; Marić, Gorana; Kotarski, Ljerka; Forcic, Dubravko

Year: 2013

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-012-4394-4

Paper Cupriavidus metallidurans biomineralization ability and its application as a bioconsolidation enhancer for ornamental marble stone.

Daskalakis, Markos I; Magoulas, Antonis; Kotoulas, Georgios et al. · 2014 · Applied microbiology and biotechnology · DOI

Full title: Cupriavidus metallidurans biomineralization ability and its application as a bioconsolidation enhancer for ornamental marble stone.

Authors: Daskalakis, Markos I; Magoulas, Antonis; Kotoulas, Georgios; Katsikis, Ioannis; Bakolas, Asterios; Karageorgis, Aristomenis P; Mavridou, Athena; Doulia, Danae; Rigas, Fotis

Year: 2014

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-014-5753-0

Paper Optimization of alkaline protease production by Aspergillus clavatus ES1 in Mirabilis jalapa tuber powder using statistical experimental design.

Hajji, Mohamed; Rebai, Ahmed; Gharsallah, Néji et al. · 2008 · Applied microbiology and biotechnology · DOI

Full title: Optimization of alkaline protease production by Aspergillus clavatus ES1 in Mirabilis jalapa tuber powder using statistical experimental design.

Authors: Hajji, Mohamed; Rebai, Ahmed; Gharsallah, Néji; Nasri, Moncef

Year: 2008

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-008-1508-0

Paper Optimizing emulsan production of A. venetianus RAG-1 using response surface methodology.

Su, Wen-Ta; Chen, Wen-Jang; Lin, Yi-Fan · 2009 · Applied microbiology and biotechnology · DOI

Full title: Optimizing emulsan production of A. venetianus RAG-1 using response surface methodology.

Authors: Su, Wen-Ta; Chen, Wen-Jang; Lin, Yi-Fan

Year: 2009

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-009-1957-0

Paper Stepwise optimization of recombinant protein production in Escherichia coli utilizing computational and experimental approaches.

Packiam, Kulandai Arockia Rajesh; Ramanan, Ramakrishnan Nagasundara; Ooi, Chien Wei et al. · 2020 · Applied microbiology and biotechnology · DOI

Full title: Stepwise optimization of recombinant protein production in Escherichia coli utilizing computational and experimental approaches.

Authors: Packiam, Kulandai Arockia Rajesh; Ramanan, Ramakrishnan Nagasundara; Ooi, Chien Wei; Krishnaswamy, Lakshminarasimhan; Tey, Beng Ti

Year: 2020

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-020-10454-w

Paper Capsular polysaccharide production by Streptococcus pneumoniae serotype 1: from strain selection to fed-batch cultivation.

Marthos, Bruno Vitorio; Ferri, Anne Letícia Silva; de Figueiredo, Douglas Borges et al. · 2015 · Applied microbiology and biotechnology · DOI

Full title: Capsular polysaccharide production by Streptococcus pneumoniae serotype 1: from strain selection to fed-batch cultivation.

Authors: Marthos, Bruno Vitorio; Ferri, Anne Letícia Silva; de Figueiredo, Douglas Borges; Zangirolami, Teresa Cristina; Gonçalves, Viviane Maimoni

Year: 2015

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-015-6928-z

Paper Chitinase production in solid-state fermentation by Enterobacter sp. NRG4 using statistical experimental design.

Dahiya, Neetu; Tewari, Rupinder; Tiwari, Ram Prakash et al. · 2005 · Current microbiology · DOI

Full title: Chitinase production in solid-state fermentation by Enterobacter sp. NRG4 using statistical experimental design.

Authors: Dahiya, Neetu; Tewari, Rupinder; Tiwari, Ram Prakash; Hoondal, Gurinder Singh

Year: 2005

Venue: Current microbiology

DOI: https://doi.org/10.1007/s00284-005-4520-y

Paper Lysis and IB washing procedures significantly impact the recovery of rHumanized ranibizumab from inclusion bodies expressed in Escherichia coli.

Patil, Rucha S; Khan, Nida; Rathore, Anurag S · 2026 · Bioprocess and biosystems engineering · DOI

Full title: Lysis and IB washing procedures significantly impact the recovery of rHumanized ranibizumab from inclusion bodies expressed in Escherichia coli.

Authors: Patil, Rucha S; Khan, Nida; Rathore, Anurag S

Year: 2026

Venue: Bioprocess and biosystems engineering

DOI: https://doi.org/10.1007/s00449-025-03241-2

Paper Enhanced production of amidase from Rhodococcus erythropolis MTCC 1526 by medium optimisation using a statistical experimental design.

Vaidya, Bhalchandra K; Mutalik, Snehal R; Joshi, Renuka M et al. · 2009 · Journal of industrial microbiology & biotechnology · DOI

Full title: Enhanced production of amidase from Rhodococcus erythropolis MTCC 1526 by medium optimisation using a statistical experimental design.

Authors: Vaidya, Bhalchandra K; Mutalik, Snehal R; Joshi, Renuka M; Nene, Sanjay N; Kulkarni, Bhaskar D

Year: 2009

Venue: Journal of industrial microbiology & biotechnology

DOI: https://doi.org/10.1007/s10295-009-0536-9

Paper Application of Response Surface Methodology For Modeling and Optimization of A Bio Coagulation Process (Sewage Wastewater Treatment Plant).

Ayat, Asma; Arris, Sihem; Abbaz, Amina et al. · 2021 · Environmental management · DOI

Full title: Application of Response Surface Methodology For Modeling and Optimization of A Bio Coagulation Process (Sewage Wastewater Treatment Plant).

Authors: Ayat, Asma; Arris, Sihem; Abbaz, Amina; Bencheikh-Lehocine, Mossaab; Meniai, Abdeslam Hassen

Year: 2021

Venue: Environmental management

DOI: https://doi.org/10.1007/s00267-020-01407-0

Paper Optimization of fermentation parameters in phage production using response surface methodology.

Grieco, Sung-Hye H; Wong, Ann Y K; Dunbar, W Scott et al. · 2012 · Journal of industrial microbiology & biotechnology · DOI

Full title: Optimization of fermentation parameters in phage production using response surface methodology.

Authors: Grieco, Sung-Hye H; Wong, Ann Y K; Dunbar, W Scott; MacGillivray, Ross T A; Curtis, Susan B

Year: 2012

Venue: Journal of industrial microbiology & biotechnology

DOI: https://doi.org/10.1007/s10295-012-1148-3

Paper Process mapping and optimization study of CHO cell cultures for mAb production using Ambr® 250 high-throughput parallel bioreactors.

Bordoloi, A; Rowshan, F Talebnia · 2025 · Bioprocess and biosystems engineering · DOI

Full title: Process mapping and optimization study of CHO cell cultures for mAb production using Ambr® 250 high-throughput parallel bioreactors.

Authors: Bordoloi, A; Rowshan, F Talebnia

Year: 2025

Venue: Bioprocess and biosystems engineering

DOI: https://doi.org/10.1007/s00449-025-03229-y

Paper Improvement of sordarin production through process optimization: combining traditional approaches with DOE.

Tully, Thomas P; Bergum, James S; Schwarz, Steven R et al. · 2007 · Journal of industrial microbiology & biotechnology · DOI

Full title: Improvement of sordarin production through process optimization: combining traditional approaches with DOE.

Authors: Tully, Thomas P; Bergum, James S; Schwarz, Steven R; Durand, Susan C; Howell, Jeffrey M; Patel, Ramesh N; Cino, Paul M

Year: 2007

Venue: Journal of industrial microbiology & biotechnology

DOI: https://doi.org/10.1007/s10295-006-0186-0

Paper Upstream development of Escherichia coli fermentation process with PhoA promoter using design of experiments (DoE).

Agbogbo, Frank K; Ramsey, Phil; George, Renija et al. · 2020 · Journal of industrial microbiology & biotechnology · DOI

Full title: Upstream development of Escherichia coli fermentation process with PhoA promoter using design of experiments (DoE).

Authors: Agbogbo, Frank K; Ramsey, Phil; George, Renija; Joy, Jobin; Srivastava, Shikha; Huang, Mian; McCool, Jesse

Year: 2020

Venue: Journal of industrial microbiology & biotechnology

DOI: https://doi.org/10.1007/s10295-020-02302-7

Paper Microbial transformation of 2-amino-4-methyl-3-nitropyridine.

Tully, Thomas; Liu, Mark; Huang, Yande et al. · 2012 · Journal of industrial microbiology & biotechnology · DOI

Full title: Microbial transformation of 2-amino-4-methyl-3-nitropyridine.

Authors: Tully, Thomas; Liu, Mark; Huang, Yande; Ye, Qingmei; Patel, Ramesh N; Goswami, Animesh

Year: 2012

Venue: Journal of industrial microbiology & biotechnology

DOI: https://doi.org/10.1007/s10295-012-1189-7

Paper Application of experimental design as a statistical approach to recover bioactive peptides from different food sources.

de Albuquerque Mendes, Mikael Kélvin; Dos Santos Oliveira, Christian Bremmer; da Silva Medeiros, Carla Mariana et al. · 2024 · Food science and biotechnology · DOI

Full title: Application of experimental design as a statistical approach to recover bioactive peptides from different food sources.

Authors: de Albuquerque Mendes, Mikael Kélvin; Dos Santos Oliveira, Christian Bremmer; da Silva Medeiros, Carla Mariana; Dantas, Clecio; Carrilho, Emanuel; de Araujo Nogueira, Ana Rita; Lopes Júnior, Cícero Alves; Vieira, Edivan Carvalho

Year: 2024

Venue: Food science and biotechnology

DOI: https://doi.org/10.1007/s10068-024-01540-0

Paper Optimization of ultrasound-assisted production of ergosterol from Penicillium brevicompactum by Taguchi statistical method.

Vali, Nasim; Fatemi, Seyed-Safa-Ali; Alinaghi, Masoumeh · 2022 · Biotechnology letters · DOI

Full title: Optimization of ultrasound-assisted production of ergosterol from Penicillium brevicompactum by Taguchi statistical method.

Authors: Vali, Nasim; Fatemi, Seyed-Safa-Ali; Alinaghi, Masoumeh

Year: 2022

Venue: Biotechnology letters

DOI: https://doi.org/10.1007/s10529-022-03297-0

Paper Optimization of a serum-free culture medium for mouse embryonic stem cells using design of experiments (DoE) methodology.

Knöspel, Fanny; Schindler, Rudolf K; Lübberstedt, Marc et al. · 2010 · Cytotechnology · DOI

Full title: Optimization of a serum-free culture medium for mouse embryonic stem cells using design of experiments (DoE) methodology.

Authors: Knöspel, Fanny; Schindler, Rudolf K; Lübberstedt, Marc; Petzolt, Stephanie; Gerlach, Jörg C; Zeilinger, Katrin

Year: 2010

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-010-9307-8

Paper Evaluation and optimization of hepatocyte culture media factors by design of experiments (DoE) methodology.

Dong, Jia; Mandenius, Carl-Fredrik; Lübberstedt, Marc et al. · 2008 · Cytotechnology · DOI

Full title: Evaluation and optimization of hepatocyte culture media factors by design of experiments (DoE) methodology.

Authors: Dong, Jia; Mandenius, Carl-Fredrik; Lübberstedt, Marc; Urbaniak, Thomas; Nüssler, Andreas K N; Knobeloch, Daniel; Gerlach, Jörg C; Zeilinger, Katrin

Year: 2008

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-008-9168-6

Paper Engineering of an inhalable DDA/TDB liposomal adjuvant: a quality-by-design approach towards optimization of the spray drying process.

Ingvarsson, Pall Thor; Yang, Mingshi; Mulvad, Helle et al. · 2013 · Pharmaceutical research · DOI

Full title: Engineering of an inhalable DDA/TDB liposomal adjuvant: a quality-by-design approach towards optimization of the spray drying process.

Authors: Ingvarsson, Pall Thor; Yang, Mingshi; Mulvad, Helle; Nielsen, Hanne Mørck; Rantanen, Jukka; Foged, Camilla

Year: 2013

Venue: Pharmaceutical research

DOI: https://doi.org/10.1007/s11095-013-1096-2

Paper Enhanced decolourization of Direct Red-80 dye by the white rot fungus Phanerochaete chrysosporium employing sequential design of experiments.

Singh, Sukhwinder; Pakshirajan, Kannan; Daverey, Achlesh · 2010 · Biodegradation · DOI

Full title: Enhanced decolourization of Direct Red-80 dye by the white rot fungus Phanerochaete chrysosporium employing sequential design of experiments.

Authors: Singh, Sukhwinder; Pakshirajan, Kannan; Daverey, Achlesh

Year: 2010

Venue: Biodegradation

DOI: https://doi.org/10.1007/s10532-009-9319-2

Paper Coagulant recovery from water treatment plant sludge and reuse in post-treatment of UASB reactor effluent treating municipal wastewater.

Nair, Abhilash T; Ahammed, M Mansoor · 2014 · Environmental science and pollution research international · DOI

Full title: Coagulant recovery from water treatment plant sludge and reuse in post-treatment of UASB reactor effluent treating municipal wastewater.

Authors: Nair, Abhilash T; Ahammed, M Mansoor

Year: 2014

Venue: Environmental science and pollution research international

DOI: https://doi.org/10.1007/s11356-014-2900-1

Paper Optimization of o-Chlorophenol Biodegradation by Combined Mycelial Pellets Using Response Surface Methodology

Yihua Dong; Liang Li; Xiaomin Hu et al. · 2017 · Water, Air and Soil Pollution · DOI

Full title: Optimization of o-Chlorophenol Biodegradation by Combined Mycelial Pellets Using Response Surface Methodology

Authors: Yihua Dong; Liang Li; Xiaomin Hu; Cheng-Xun Wu

Year: 2017

Venue: Water, Air and Soil Pollution

DOI: https://doi.org/10.1007/s11270-017-3606-z

Paper Comprehensive Optimization of LC-MS Metabolomics Methods Using Design of Experiments (COLMeD).

Rhoades, Seth D; Weljie, Aalim M · 2016 · Metabolomics : Official journal of the Metabolomic Society · DOI

Full title: Comprehensive Optimization of LC-MS Metabolomics Methods Using Design of Experiments (COLMeD).

Authors: Rhoades, Seth D; Weljie, Aalim M

Year: 2016

Venue: Metabolomics : Official journal of the Metabolomic Society

DOI: https://doi.org/10.1007/s11306-016-1132-4

Paper Production and optimization of biodiesel using mixed immobilized biocatalysts in packed bed reactor.

Bakkiyaraj, S; Syed, Mahin Basha; Devanesan, M G et al. · 2016 · Environmental science and pollution research international · DOI

Full title: Production and optimization of biodiesel using mixed immobilized biocatalysts in packed bed reactor.

Authors: Bakkiyaraj, S; Syed, Mahin Basha; Devanesan, M G; Thangavelu, Viruthagiri

Year: 2016

Venue: Environmental science and pollution research international

DOI: https://doi.org/10.1007/s11356-015-4583-7

Paper Optimisation of critical medium components and culture conditions for enhanced biomass and lipid production in the oleaginous diatom Navicula phyllepta: a statistical approach.

Sabu, Sanyo; Singh, Isaac Sarojini Bright; Joseph, Valsamma · 2017 · Environmental science and pollution research international · DOI

Full title: Optimisation of critical medium components and culture conditions for enhanced biomass and lipid production in the oleaginous diatom Navicula phyllepta: a statistical approach.

Authors: Sabu, Sanyo; Singh, Isaac Sarojini Bright; Joseph, Valsamma

Year: 2017

Venue: Environmental science and pollution research international

DOI: https://doi.org/10.1007/s11356-017-0274-x

Paper Optimization of crucial reaction conditions for the production of nicotinamide by nitrile hydratase using response surface methodology.

Kamble, Ashwini; Banerjee, U C · 2008 · Applied biochemistry and biotechnology · DOI

Full title: Optimization of crucial reaction conditions for the production of nicotinamide by nitrile hydratase using response surface methodology.

Authors: Kamble, Ashwini; Banerjee, U C

Year: 2008

Venue: Applied biochemistry and biotechnology

DOI: https://doi.org/10.1007/s12010-008-8161-z

Paper Enhancement of Aeribacillus pallidus strain VP3 lipase catalytic activity through optimization of medium composition using Box-Behnken design and its application in detergent formulations.

Ktata, Ameni; Karray, Aida; Mnif, Ines et al. · 2020 · Environmental science and pollution research international · DOI

Full title: Enhancement of Aeribacillus pallidus strain VP3 lipase catalytic activity through optimization of medium composition using Box-Behnken design and its application in detergent formulations.

Authors: Ktata, Ameni; Karray, Aida; Mnif, Ines; Bezzine, Sofiane

Year: 2020

Venue: Environmental science and pollution research international

DOI: https://doi.org/10.1007/s11356-020-07853-x

Paper Characterization of a monoclonal antibody cell culture production process using a quality by design approach.

Horvath, Brian; Mun, Melissa; Laird, Michael W · 2010 · Molecular biotechnology · DOI

Full title: Characterization of a monoclonal antibody cell culture production process using a quality by design approach.

Authors: Horvath, Brian; Mun, Melissa; Laird, Michael W

Year: 2010

Venue: Molecular biotechnology

DOI: https://doi.org/10.1007/s12033-010-9267-4

Paper A statistical approach for optimization of polyhydroxybutyrate production by Bacillus sphaericus NCIM 5149 under submerged fermentation using central composite design.

Ramadas, Nisha V; Soccol, Carlos R; Pandey, Ashok · 2010 · Applied biochemistry and biotechnology · DOI

Full title: A statistical approach for optimization of polyhydroxybutyrate production by Bacillus sphaericus NCIM 5149 under submerged fermentation using central composite design.

Authors: Ramadas, Nisha V; Soccol, Carlos R; Pandey, Ashok

Year: 2010

Venue: Applied biochemistry and biotechnology

DOI: https://doi.org/10.1007/s12010-009-8807-5

Paper Optimization of Soluble Expression and Purification of Recombinant Human Rhinovirus Type-14 3C Protease Using Statistically Designed Experiments: Isolation and Characterization of the Enzyme.

Antoniou, Georgia; Papakyriacou, Irineos; Papaneophytou, Christos · 2017 · Molecular biotechnology · DOI

Full title: Optimization of Soluble Expression and Purification of Recombinant Human Rhinovirus Type-14 3C Protease Using Statistically Designed Experiments: Isolation and Characterization of the Enzyme.

Authors: Antoniou, Georgia; Papakyriacou, Irineos; Papaneophytou, Christos

Year: 2017

Venue: Molecular biotechnology

DOI: https://doi.org/10.1007/s12033-017-0032-9

Paper Process Optimization for Biosurfactant Production by Bacillus aryabhattai SPS1001 using Taguchi Method.

Fatima, Farkhunda; Tiwari, Nishi Prakash; Singh, Varsha · 2025 · Applied biochemistry and biotechnology · DOI

Full title: Process Optimization for Biosurfactant Production by Bacillus aryabhattai SPS1001 using Taguchi Method.

Authors: Fatima, Farkhunda; Tiwari, Nishi Prakash; Singh, Varsha

Year: 2025

Venue: Applied biochemistry and biotechnology

DOI: https://doi.org/10.1007/s12010-024-05019-w

Paper Statistical experimental design optimization of rhamsan gum production by Sphingomonas sp. CGMCC 6833.

Xu, Xiao-Ying; Dong, Shu-Hao; Li, Sha et al. · 2015 · Journal of microbiology (Seoul, Korea) · DOI

Full title: Statistical experimental design optimization of rhamsan gum production by Sphingomonas sp. CGMCC 6833.

Authors: Xu, Xiao-Ying; Dong, Shu-Hao; Li, Sha; Chen, Xiao-Ye; Wu, Ding; Xu, Hong

Year: 2015

Venue: Journal of microbiology (Seoul, Korea)

DOI: https://doi.org/10.1007/s12275-015-3662-2

Paper Analyzing the Impact of Physicochemical Factors on Chlorella vulgaris Growth Through Design of Experiment (DoE) for Carbon Capture System.

Nurrusyda, Fajriana Shafira; Subroto, Toto; Hardianto, Ari et al. · 2024 · Molecular biotechnology · DOI

Full title: Analyzing the Impact of Physicochemical Factors on Chlorella vulgaris Growth Through Design of Experiment (DoE) for Carbon Capture System.

Authors: Nurrusyda, Fajriana Shafira; Subroto, Toto; Hardianto, Ari; Sumeru, Husain Akbar; Ishmayana, Safri; Pratomo, Uji; Oktavia, Diah N; Latifah, Rina G; Dewi, Dewa A S L A; Rachmadona, Nova

Year: 2024

Venue: Molecular biotechnology

DOI: https://doi.org/10.1007/s12033-023-01036-y

Paper Design of Experiments As a Tool for Optimization in Recombinant Protein Biotechnology: From Constructs to Crystals.

Papaneophytou, Christos · 2019 · Molecular biotechnology · DOI

Full title: Design of Experiments As a Tool for Optimization in Recombinant Protein Biotechnology: From Constructs to Crystals.

Authors: Papaneophytou, Christos

Year: 2019

Venue: Molecular biotechnology

DOI: https://doi.org/10.1007/s12033-019-00218-x

Paper Toward the Development of a Biosimilar Variant of Glucarpidase (Carboxypeptidase G2): Secretory Production, Optimization, and Immobilization.

Moradbeygi, Fatemeh; Ghoshoon, Mohammad Bagher; Sadeghian, Issa et al. · 2025 · Molecular biotechnology · DOI

Full title: Toward the Development of a Biosimilar Variant of Glucarpidase (Carboxypeptidase G2): Secretory Production, Optimization, and Immobilization.

Authors: Moradbeygi, Fatemeh; Ghoshoon, Mohammad Bagher; Sadeghian, Issa; Moradi, Anahita; Ghasemi, Younes; Morowvat, Mohammad Hossein; Hemmati, Shiva

Year: 2025

Venue: Molecular biotechnology

DOI: https://doi.org/10.1007/s12033-025-01450-4

Paper Optimization of Culture Conditions for Fermentation of Soymilk Using Lactobacillus casei by Response Surface Methodology.

Khoshayand, Feriyar; Goodarzi, Sanaz; Shahverdi, Ahmad Reza et al. · 2011 · Probiotics and antimicrobial proteins · DOI

Full title: Optimization of Culture Conditions for Fermentation of Soymilk Using Lactobacillus casei by Response Surface Methodology.

Authors: Khoshayand, Feriyar; Goodarzi, Sanaz; Shahverdi, Ahmad Reza; Khoshayand, Mohammad Reza

Year: 2011

Venue: Probiotics and antimicrobial proteins

DOI: https://doi.org/10.1007/s12602-011-9079-2

Paper Response surface optimization of ultrasound-assisted protein extraction from Spirulina platensis: investigation of the effect of extraction conditions on techno-functional properties of protein concentrates.

Yücetepe, Aysun; Saroğlu, Öznur; Özçelik, Beraat · 2019 · Journal of food science and technology · DOI

Full title: Response surface optimization of ultrasound-assisted protein extraction from Spirulina platensis: investigation of the effect of extraction conditions on techno-functional properties of protein concentrates.

Authors: Yücetepe, Aysun; Saroğlu, Öznur; Özçelik, Beraat

Year: 2019

Venue: Journal of food science and technology

DOI: https://doi.org/10.1007/s13197-019-03796-5

Paper An Experimental Design to Evaluate the Effects of Process and Formulation on the Viability and Efficacy of L. reuteri Enteric-Coated Pellets in a Rat Model with Colitis.

Nouraei, Maedeh Shams; Samadi, Nasrin; Faghihi, Homa et al. · 2025 · Probiotics and antimicrobial proteins · DOI

Full title: An Experimental Design to Evaluate the Effects of Process and Formulation on the Viability and Efficacy of L. reuteri Enteric-Coated Pellets in a Rat Model with Colitis.

Authors: Nouraei, Maedeh Shams; Samadi, Nasrin; Faghihi, Homa; Sharifzadeh, Mohammad; Moraffah, Fatemeh; Kiani-Dehkordi, Banafsheh; Ebrahimi, Maryam Tajabadi; Vatanara, Alireza

Year: 2025

Venue: Probiotics and antimicrobial proteins

DOI: https://doi.org/10.1007/s12602-025-10787-w

Paper Optimization of Astaxanthin microencapsulation in hydrophilic carriers using response surface methodology.

Nalawade, Pravin; Gajjar, Anuradha · 2015 · Archives of pharmacal research · DOI

Full title: Optimization of Astaxanthin microencapsulation in hydrophilic carriers using response surface methodology.

Authors: Nalawade, Pravin; Gajjar, Anuradha

Year: 2015

Venue: Archives of pharmacal research

DOI: https://doi.org/10.1007/s12272-015-0693-5

Paper Design of experiments (DoE) to model phenolic compounds recovery from grape pomace using ultrasounds.

Ćućuz, Veljko; Cvejić, Jelena; Torović, Ljilja et al. · 2022 · Journal of food science and technology · DOI

Full title: Design of experiments (DoE) to model phenolic compounds recovery from grape pomace using ultrasounds.

Authors: Ćućuz, Veljko; Cvejić, Jelena; Torović, Ljilja; Gojković-Bukarica, Ljiljana; Acevska, Jelena; Dimitrovska, Aneta; Aldawoud, Turki M S; Galanakis, Charis M

Year: 2022

Venue: Journal of food science and technology

DOI: https://doi.org/10.1007/s13197-021-05317-9

Paper Improving proteome coverage on a LTQ-Orbitrap using design of experiments.

Andrews, Genna L; Dean, Ralph A; Hawkridge, Adam M et al. · 2011 · Journal of the American Society for Mass Spectrometry · DOI

Full title: Improving proteome coverage on a LTQ-Orbitrap using design of experiments.

Authors: Andrews, Genna L; Dean, Ralph A; Hawkridge, Adam M; Muddiman, David C

Year: 2011

Venue: Journal of the American Society for Mass Spectrometry

DOI: https://doi.org/10.1007/s13361-011-0075-2

Paper Quality-by-design principles applied to the development and optimisation of lidocaine-loaded dissolving microneedle arrays - a proof-of-concept.

Yong, Pei Gie; Segorean, Ana-Manuela; Cordeiro, Ana Sara · 2025 · Drug delivery and translational research · DOI

Full title: Quality-by-design principles applied to the development and optimisation of lidocaine-loaded dissolving microneedle arrays - a proof-of-concept.

Authors: Yong, Pei Gie; Segorean, Ana-Manuela; Cordeiro, Ana Sara

Year: 2025

Venue: Drug delivery and translational research

DOI: https://doi.org/10.1007/s13346-024-01758-9

Paper The role of statistical methods in optimizing and enhancing fungal chitosan commercial production.

Karamchandani, Bhoomika M; Maurya, Priya A; Pawar, Ameya A et al. · 2025 · 3 Biotech · DOI

Full title: The role of statistical methods in optimizing and enhancing fungal chitosan commercial production.

Authors: Karamchandani, Bhoomika M; Maurya, Priya A; Pawar, Ameya A; Pable, Anupama; Awale, Manik; Dalvi, Sunil G; Banat, Ibrahim M; Satpute, Surekha K

Year: 2025

Venue: 3 Biotech

DOI: https://doi.org/10.1007/s13205-025-04236-2

Paper The hybrid experimental simplex algorithm--an alternative method for 'sweet spot' identification in early bioprocess development: case studies in ion exchange chromatography.

Konstantinidis, Spyridon; Chhatre, Sunil; Velayudhan, Ajoy et al. · 2012 · Analytica chimica acta · DOI

Full title: The hybrid experimental simplex algorithm--an alternative method for 'sweet spot' identification in early bioprocess development: case studies in ion exchange chromatography.

Authors: Konstantinidis, Spyridon; Chhatre, Sunil; Velayudhan, Ajoy; Heldin, Eva; Titchener-Hooker, Nigel

Year: 2012

Venue: Analytica chimica acta

DOI: https://doi.org/10.1016/j.aca.2012.06.039

Paper A high-resolution multi-attribute method for product characterization, process characterization, and quality control of therapeutic proteins.

Guan, Xiaoyan; Eris, Tamer; Zhang, Le et al. · 2022 · Analytical biochemistry · DOI

Full title: A high-resolution multi-attribute method for product characterization, process characterization, and quality control of therapeutic proteins.

Authors: Guan, Xiaoyan; Eris, Tamer; Zhang, Le; Ren, Da; Ricci, Margaret S; Thiel, Tiffany; Goudar, Chetan T

Year: 2022

Venue: Analytical biochemistry

DOI: https://doi.org/10.1016/j.ab.2022.114575

Paper Artificial neural network and response surface methodology modeling in mass transfer parameters predictions during osmotic dehydration of Carica papaya L.

J. Maran; V. Sivakumar; K. Thirugnanasambandham et al. · 2013 · DOI

Full title: Artificial neural network and response surface methodology modeling in mass transfer parameters predictions during osmotic dehydration of Carica papaya L.

Authors: J. Maran; V. Sivakumar; K. Thirugnanasambandham; R. Sridhar

Year: 2013

DOI: https://doi.org/10.1016/j.aej.2013.06.007

Paper Boosting model performance and interpretation by entangling preprocessing selection and variable selection.

Gerretzen, Jan; Szymańska, Ewa; Bart, Jacob et al. · 2016 · Analytica chimica acta · DOI

Full title: Boosting model performance and interpretation by entangling preprocessing selection and variable selection.

Authors: Gerretzen, Jan; Szymańska, Ewa; Bart, Jacob; Davies, Antony N; van Manen, Henk-Jan; van den Heuvel, Edwin R; Jansen, Jeroen J; Buydens, Lutgarde M C

Year: 2016

Venue: Analytica chimica acta

DOI: https://doi.org/10.1016/j.aca.2016.08.022

Paper Enantioseparation of tropic acid by biphasic enantioselective liquid-liquid extraction: Experimental and simulation.

Chenggong Zhou; Shaofen Lai; Zhihong Yan et al. · 2025 · Analytica Chimica Acta · DOI

Full title: Enantioseparation of tropic acid by biphasic enantioselective liquid-liquid extraction: Experimental and simulation.

Authors: Chenggong Zhou; Shaofen Lai; Zhihong Yan; Weiyang Tang; Genlin Sun

Year: 2025

Venue: Analytica Chimica Acta

DOI: https://doi.org/10.1016/j.aca.2025.344790

Paper Experimental designs for solid-phase microextraction method development in bioanalysis: A review.

Marrubini, Giorgio; Dugheri, Stefano; Cappelli, Giovanni et al. · 2020 · Analytica chimica acta · DOI

Full title: Experimental designs for solid-phase microextraction method development in bioanalysis: A review.

Authors: Marrubini, Giorgio; Dugheri, Stefano; Cappelli, Giovanni; Arcangeli, Giulio; Mucci, Nicola; Appelblad, Patrik; Melzi, Camillo; Speltini, Andrea

Year: 2020

Venue: Analytica chimica acta

DOI: https://doi.org/10.1016/j.aca.2020.04.012

Paper Optimal design of experiments applied to headspace solid phase microextraction for the quantification of vicinal diketones in beer through gas chromatography-mass spectrometric detection.

Leça, João M; Pereira, Ana C; Vieira, Ana C et al. · 2015 · Analytica chimica acta · DOI

Full title: Optimal design of experiments applied to headspace solid phase microextraction for the quantification of vicinal diketones in beer through gas chromatography-mass spectrometric detection.

Authors: Leça, João M; Pereira, Ana C; Vieira, Ana C; Reis, Marco S; Marques, José C

Year: 2015

Venue: Analytica chimica acta

DOI: https://doi.org/10.1016/j.aca.2015.06.044

Paper Development and validation of mathematical models for testing antifungal activity of different essential oils against Candida species.

Mirjana Perić; K. Rajkovic; Aleksandra Milić Lemić et al. · 2019 · Archives of Oral Biology · DOI

Full title: Development and validation of mathematical models for testing antifungal activity of different essential oils against Candida species.

Authors: Mirjana Perić; K. Rajkovic; Aleksandra Milić Lemić; R. Živković; V. Arsić Arsenijević

Year: 2019

Venue: Archives of Oral Biology

DOI: https://doi.org/10.1016/j.archoralbio.2018.11.029

Paper Production of multiple xylanolytic and cellulolytic enzymes by thermophilic fungus Myceliophthora sp. IMI 387099.

Badhan, A K; Chadha, B S; Kaur, Jatinder et al. · 2007 · Bioresource technology · DOI

Full title: Production of multiple xylanolytic and cellulolytic enzymes by thermophilic fungus Myceliophthora sp. IMI 387099.

Authors: Badhan, A K; Chadha, B S; Kaur, Jatinder; Saini, H S; Bhat, M K

Year: 2007

Venue: Bioresource technology

DOI: https://doi.org/10.1016/j.biortech.2006.02.009

Paper Optimized simultaneous saccharification and co-fermentation of rice straw for ethanol production by Saccharomyces cerevisiae and Scheffersomyces stipitis co-culture using design of experiments.

Suriyachai, Nopparat; Weerasaia, Khatiya; Laosiripojana, Navadol et al. · 2013 · Bioresource technology · DOI

Full title: Optimized simultaneous saccharification and co-fermentation of rice straw for ethanol production by Saccharomyces cerevisiae and Scheffersomyces stipitis co-culture using design of experiments.

Authors: Suriyachai, Nopparat; Weerasaia, Khatiya; Laosiripojana, Navadol; Champreda, Verawat; Unrean, Pornkamol

Year: 2013

Venue: Bioresource technology

DOI: https://doi.org/10.1016/j.biortech.2013.05.003

Paper Economical production of agricultural γ-polyglutamic acid using industrial wastes by Bacillus subtilis

Chao Zhang; Daoji Wu; Huixue Ren · 2019 · Biochemical engineering journal · DOI

Full title: Economical production of agricultural γ-polyglutamic acid using industrial wastes by Bacillus subtilis

Authors: Chao Zhang; Daoji Wu; Huixue Ren

Year: 2019

Venue: Biochemical engineering journal

DOI: https://doi.org/10.1016/j.bej.2019.03.013

Paper Optimization of medium composition for alkali-stable xylanase production by Aspergillus fischeri Fxn 1 in solid-state fermentation using central composite rotary design.

Senthilkumar, S R; Ashokkumar, B; Chandra Raj, K et al. · 2005 · Bioresource technology · DOI

Full title: Optimization of medium composition for alkali-stable xylanase production by Aspergillus fischeri Fxn 1 in solid-state fermentation using central composite rotary design.

Authors: Senthilkumar, S R; Ashokkumar, B; Chandra Raj, K; Gunasekaran, P

Year: 2005

Venue: Bioresource technology

DOI: https://doi.org/10.1016/j.biortech.2004.11.005

Paper Evaluation of a DoE based approach for comprehensive modelling of the effect of lipid nanoparticle composition on nucleic acid delivery.

Qin, Yue; Walters, Adam A; Rouatbi, Nadia et al. · 2023 · Biomaterials · DOI

Full title: Evaluation of a DoE based approach for comprehensive modelling of the effect of lipid nanoparticle composition on nucleic acid delivery.

Authors: Qin, Yue; Walters, Adam A; Rouatbi, Nadia; Wang, Julie Tzu-Wen; Abdel-Bar, Hend Mohamed; Al-Jamal, Khuloud T

Year: 2023

Venue: Biomaterials

DOI: https://doi.org/10.1016/j.biomaterials.2023.122158

Paper Optimization of electron donors to improve CO2 fixation efficiency by a non-photosynthetic microbial community under aerobic condition using statistical experimental design.

Hu, Jia-jun; Wang, Lei; Zhang, Shi-ping et al. · 2010 · Bioresource technology · DOI

Full title: Optimization of electron donors to improve CO2 fixation efficiency by a non-photosynthetic microbial community under aerobic condition using statistical experimental design.

Authors: Hu, Jia-jun; Wang, Lei; Zhang, Shi-ping; Fu, Xiao-hua; Le, Yi-quan

Year: 2010

Venue: Bioresource technology

DOI: https://doi.org/10.1016/j.biortech.2010.03.138

Paper Application of response surface methodology and artificial neural network methods in modelling and optimization of biosorption process.

Witek-Krowiak, Anna; Chojnacka, Katarzyna; Podstawczyk, Daria et al. · 2014 · Bioresource technology · DOI

Full title: Application of response surface methodology and artificial neural network methods in modelling and optimization of biosorption process.

Authors: Witek-Krowiak, Anna; Chojnacka, Katarzyna; Podstawczyk, Daria; Dawiec, Anna; Bubała, Karol

Year: 2014

Venue: Bioresource technology

DOI: https://doi.org/10.1016/j.biortech.2014.01.021

Paper The use of Design of Experiments and Response Surface Methodology to optimize biomass and lipid production by the oleaginous marine green alga, Nannochloropsis gaditana in response to light intensity, inoculum size and CO2.

Hallenbeck, Patrick C; Grogger, Melanie; Mraz, Megan et al. · 2015 · Bioresource technology · DOI

Full title: The use of Design of Experiments and Response Surface Methodology to optimize biomass and lipid production by the oleaginous marine green alga, Nannochloropsis gaditana in response to light intensity, inoculum size and CO2.

Authors: Hallenbeck, Patrick C; Grogger, Melanie; Mraz, Megan; Veverka, Donald

Year: 2015

Venue: Bioresource technology

DOI: https://doi.org/10.1016/j.biortech.2014.09.022

Paper Optimization of medium composition for butyric acid production by Clostridium thermobutyricum using response surface methodology.

Zhang, Chun-Hui; Ma, Yu-Jiu; Yang, Fang-Xiao et al. · 2009 · Bioresource technology · DOI

Full title: Optimization of medium composition for butyric acid production by Clostridium thermobutyricum using response surface methodology.

Authors: Zhang, Chun-Hui; Ma, Yu-Jiu; Yang, Fang-Xiao; Liu, Wei; Zhang, Yue-Dong

Year: 2009

Venue: Bioresource technology

DOI: https://doi.org/10.1016/j.biortech.2009.03.022

Paper The use of laboratory scale reactors to predict sensitivity to changes in operating conditions for full-scale anaerobic digestion treating municipal sewage sludge.

McLeod, James D; Othman, Maazuza Z; Beale, David J et al. · 2015 · Bioresource technology · DOI

Full title: The use of laboratory scale reactors to predict sensitivity to changes in operating conditions for full-scale anaerobic digestion treating municipal sewage sludge.

Authors: McLeod, James D; Othman, Maazuza Z; Beale, David J; Joshi, Deepak

Year: 2015

Venue: Bioresource technology

DOI: https://doi.org/10.1016/j.biortech.2015.04.049

Paper Development of a genosensor for peanut allergen ARA h 2 detection and its optimization by surface response methodology.

López, Marta Sánchez-Paniagua; Cabanillas, Gloria Frutos; Castañón, M Jesús Lobo et al. · 2014 · Biosensors & bioelectronics · DOI

Full title: Development of a genosensor for peanut allergen ARA h 2 detection and its optimization by surface response methodology.

Authors: López, Marta Sánchez-Paniagua; Cabanillas, Gloria Frutos; Castañón, M Jesús Lobo; López-Ruiz, Beatriz

Year: 2014

Venue: Biosensors & bioelectronics

DOI: https://doi.org/10.1016/j.bios.2014.06.065

Paper Building a better mousetrap II: using Design of Experiments with unconfounded ions to compare the growth of different microalgae.

Hallenbeck, Patrick C; Grogger, Melanie; Mraz, Megan et al. · 2015 · Bioresource technology · DOI

Full title: Building a better mousetrap II: using Design of Experiments with unconfounded ions to compare the growth of different microalgae.

Authors: Hallenbeck, Patrick C; Grogger, Melanie; Mraz, Megan; Veverka, Donald

Year: 2015

Venue: Bioresource technology

DOI: https://doi.org/10.1016/j.biortech.2014.11.006

Paper Process optimization of the polyhydroxybutyrate production in the cyanobacteria Synechocystis sp. and Synechococcus sp.

Rueda, Estel; Altamira-Algarra, Beatriz; García, Joan · 2022 · Bioresource technology · DOI

Full title: Process optimization of the polyhydroxybutyrate production in the cyanobacteria Synechocystis sp. and Synechococcus sp.

Authors: Rueda, Estel; Altamira-Algarra, Beatriz; García, Joan

Year: 2022

Venue: Bioresource technology

DOI: https://doi.org/10.1016/j.biortech.2022.127330

Paper Quantifying second generation ethanol inhibition: Design of Experiments approach and kinetic model development.

Schneiderman, Steven J; Johnson, Roger W; Menkhaus, Todd J et al. · 2015 · Bioresource technology · DOI

Full title: Quantifying second generation ethanol inhibition: Design of Experiments approach and kinetic model development.

Authors: Schneiderman, Steven J; Johnson, Roger W; Menkhaus, Todd J; Gilcrease, Patrick C

Year: 2015

Venue: Bioresource technology

DOI: https://doi.org/10.1016/j.biortech.2014.11.087

Paper An improvement of surfactin production by B. subtilis BBG131 using design of experiments in microbioreactors and continuous process in bubbleless membrane bioreactor.

Motta Dos Santos, Luiz Fernando; Coutte, François; Ravallec, Rozenn et al. · 2016 · Bioresource technology · DOI

Full title: An improvement of surfactin production by B. subtilis BBG131 using design of experiments in microbioreactors and continuous process in bubbleless membrane bioreactor.

Authors: Motta Dos Santos, Luiz Fernando; Coutte, François; Ravallec, Rozenn; Dhulster, Pascal; Tournier-Couturier, Lucie; Jacques, Philippe

Year: 2016

Venue: Bioresource technology

DOI: https://doi.org/10.1016/j.biortech.2016.07.053

Paper Reliable protocol using gradient boosting decision tree with limited experimental data to modify membrane surface for enhanced resilience and nitrogen removal in biofilm system.

Jie Wang; Qi Shen; Senyao Zhang et al. · 2025 · Bioresource Technology · DOI

Full title: Reliable protocol using gradient boosting decision tree with limited experimental data to modify membrane surface for enhanced resilience and nitrogen removal in biofilm system.

Authors: Jie Wang; Qi Shen; Senyao Zhang; Chunyan Yuan; Mingming Wang; Honghua Tu; Liang Feng; Feiyun Sun

Year: 2025

Venue: Bioresource Technology

DOI: https://doi.org/10.1016/j.biortech.2025.132602

Paper Optimization and kinetic study of ultrasonic assisted esterification process from rubber seed oil.

Trinh, Huong; Yusup, Suzana; Uemura, Yoshimitsu · 2018 · Bioresource technology · DOI

Full title: Optimization and kinetic study of ultrasonic assisted esterification process from rubber seed oil.

Authors: Trinh, Huong; Yusup, Suzana; Uemura, Yoshimitsu

Year: 2018

Venue: Bioresource technology

DOI: https://doi.org/10.1016/j.biortech.2017.09.075

Paper Photobioreactor strategies for improving the CO2 fixation efficiency of indigenous Scenedesmus obliquus CNW-N: statistical optimization of CO2 feeding, illumination, and operation mode.

Ho, Shih-Hsin; Lu, Wei-Bin; Chang, Jo-Shu · 2012 · Bioresource technology · DOI

Full title: Photobioreactor strategies for improving the CO2 fixation efficiency of indigenous Scenedesmus obliquus CNW-N: statistical optimization of CO2 feeding, illumination, and operation mode.

Authors: Ho, Shih-Hsin; Lu, Wei-Bin; Chang, Jo-Shu

Year: 2012

Venue: Bioresource technology

DOI: https://doi.org/10.1016/j.biortech.2011.11.091

Paper Simultaneous production of amylases and proteases by Bacillus subtilis in brewery wastes

Alina Sánchez Blanco; Osmar Palacios Durive; S. Pérez et al. · 2016 · DOI

Full title: Simultaneous production of amylases and proteases by Bacillus subtilis in brewery wastes

Authors: Alina Sánchez Blanco; Osmar Palacios Durive; S. Pérez; Zoraida Díaz Montes; N. P. Guerra

Year: 2016

DOI: https://doi.org/10.1016/j.bjm.2016.04.019

Paper Lipase production from Fusarium incarnatum KU377454 and its immobilization using Fe3O4 NPs for application in waste cooking oil degradation

R. Joshi; Rekha Sharma; Arindam Kuila · 2019 · Bioresource Technology Reports · DOI

Full title: Lipase production from Fusarium incarnatum KU377454 and its immobilization using Fe3O4 NPs for application in waste cooking oil degradation

Authors: R. Joshi; Rekha Sharma; Arindam Kuila

Year: 2019

Venue: Bioresource Technology Reports

DOI: https://doi.org/10.1016/j.biteb.2019.01.005

Paper Engineering spray-dried rosemary extracts with improved physicomechanical properties: a design of experiments issue

Chaul, Luíza Toubas; Conceição, Edemilson Cardoso da; Bara, Maria Teresa Freitas et al. · 2016 · Revista Brasileira de Farmacognosia · DOI

Full title: Engineering spray-dried rosemary extracts with improved physicomechanical properties: a design of experiments issue

Authors: Chaul, Luíza Toubas; Conceição, Edemilson Cardoso da; Bara, Maria Teresa Freitas; Paula, José Realino de; Couto, Renê Oliveira do

Year: 2016

Venue: Revista Brasileira de Farmacognosia

DOI: https://doi.org/10.1016/j.bjp.2016.10.006

Paper An iterative approach to statistical optimization of exopolysaccharide produced by fermentation of Aureobasidium pullulans.

Dsouza, Venessa; Thoidingjam, Goldee; Saleh, Abdelrahman et al. · 2025 · Biotechnology reports (Amsterdam, Netherlands) · DOI

Full title: An iterative approach to statistical optimization of exopolysaccharide produced by fermentation of Aureobasidium pullulans.

Authors: Dsouza, Venessa; Thoidingjam, Goldee; Saleh, Abdelrahman; Zavrel, Michael

Year: 2025

Venue: Biotechnology reports (Amsterdam, Netherlands)

DOI: https://doi.org/10.1016/j.btre.2025.e00914

Paper Optimization of solvent-free enzymatic esterification in eutectic substrate reaction mixture.

Pätzold, M; Weimer, A; Liese, A et al. · 2019 · Biotechnology reports (Amsterdam, Netherlands) · DOI

Full title: Optimization of solvent-free enzymatic esterification in eutectic substrate reaction mixture.

Authors: Pätzold, M; Weimer, A; Liese, A; Holtmann, D

Year: 2019

Venue: Biotechnology reports (Amsterdam, Netherlands)

DOI: https://doi.org/10.1016/j.btre.2019.e00333

Paper Exopolysaccharide production from Bacillus velezensis KY471306 using statistical experimental design.

Moghannem, Saad A M; Farag, Mohamed M S; Shehab, Amr M et al. · 2018 · Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · DOI

Full title: Exopolysaccharide production from Bacillus velezensis KY471306 using statistical experimental design.

Authors: Moghannem, Saad A M; Farag, Mohamed M S; Shehab, Amr M; Azab, Mohamed S

Year: 2018

Venue: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]

DOI: https://doi.org/10.1016/j.bjm.2017.05.012

Paper Preparation and characterization of a composite biomaterial including starch micro/nano particles loaded chitosan gel.

Dehghan Baniani, Dorsa; Bagheri, Reza; Solouk, Atefeh · 2017 · Carbohydrate polymers · DOI

Full title: Preparation and characterization of a composite biomaterial including starch micro/nano particles loaded chitosan gel.

Authors: Dehghan Baniani, Dorsa; Bagheri, Reza; Solouk, Atefeh

Year: 2017

Venue: Carbohydrate polymers

DOI: https://doi.org/10.1016/j.carbpol.2017.06.095

Paper Rational design of a scalable bioprocess platform for bacterial cellulose production.

Basu, Anindya; Vadanan, Sundaravadanam Vishnu; Lim, Sierin · 2019 · Carbohydrate polymers · DOI

Full title: Rational design of a scalable bioprocess platform for bacterial cellulose production.

Authors: Basu, Anindya; Vadanan, Sundaravadanam Vishnu; Lim, Sierin

Year: 2019

Venue: Carbohydrate polymers

DOI: https://doi.org/10.1016/j.carbpol.2018.10.085

Paper Controlled sulfation of mixed-linkage glucan by Response Surface Methodology for the development of biologically applicable polysaccharides.

Solhi, Laleh; Sun, He Song; Daswani, Sailesh Haresh et al. · 2021 · Carbohydrate polymers · DOI

Full title: Controlled sulfation of mixed-linkage glucan by Response Surface Methodology for the development of biologically applicable polysaccharides.

Authors: Solhi, Laleh; Sun, He Song; Daswani, Sailesh Haresh; Shojania, Shaheen; Springate, Christopher M K; Brumer, Harry

Year: 2021

Venue: Carbohydrate polymers

DOI: https://doi.org/10.1016/j.carbpol.2021.118275

Paper One-step immobilization of chitosanase on microcrystalline cellulose using a carbohydrate binding module family 2.

Yu, Qijun; Yang, Jinshui; Liu, Liang et al. · 2025 · Carbohydrate polymers · DOI

Full title: One-step immobilization of chitosanase on microcrystalline cellulose using a carbohydrate binding module family 2.

Authors: Yu, Qijun; Yang, Jinshui; Liu, Liang; Huang, Yaru; Wang, Entao; Li, Dongmei; Yuan, Hongli

Year: 2025

Venue: Carbohydrate polymers

DOI: https://doi.org/10.1016/j.carbpol.2025.123291

Paper Morphology and water flux of produced cellulose acetate membranes reinforced by the design of experiments (DOE).

Silva, Mónica A; Belmonte-Reche, Efres; de Amorim, M T Pessoa · 2021 · Carbohydrate polymers · DOI

Full title: Morphology and water flux of produced cellulose acetate membranes reinforced by the design of experiments (DOE).

Authors: Silva, Mónica A; Belmonte-Reche, Efres; de Amorim, M T Pessoa

Year: 2021

Venue: Carbohydrate polymers

DOI: https://doi.org/10.1016/j.carbpol.2020.117407

Paper Carboxymethylation of pectin: Optimization, characterization and in-vitro drug release studies.

Muthukumaran C.; Kanmani B.R.; Sharmila G. et al. · 2018 · Carbohydrate Polymers · DOI

Full title: Carboxymethylation of pectin: Optimization, characterization and in-vitro drug release studies.

Authors: Muthukumaran C.; Kanmani B.R.; Sharmila G.; M. N; Shanmugaprakash M.

Year: 2018

Venue: Carbohydrate Polymers

DOI: https://doi.org/10.1016/j.carbpol.2018.04.042

Paper Accurate definition of control strategies using cross validated stepwise regression and Monte Carlo simulation.

Yang, Patrick Y; Hui, Cerintha J; Tien, Daniel J et al. · 2019 · Journal of biotechnology · DOI

Full title: Accurate definition of control strategies using cross validated stepwise regression and Monte Carlo simulation.

Authors: Yang, Patrick Y; Hui, Cerintha J; Tien, Daniel J; Snowden, Andrew W; Derfus, Gayle E; Opel, Cary F

Year: 2019

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.btecx.2019.100006

Paper Design of experiments optimization of N,N,N-trimethyl chitosan synthesis using N,N-diisopropylethylamine base.

Nagy, Vivien; Snorradóttir, Bergthóra S; Lauzon, Héléne Liette et al. · 2024 · Carbohydrate research · DOI

Full title: Design of experiments optimization of N,N,N-trimethyl chitosan synthesis using N,N-diisopropylethylamine base.

Authors: Nagy, Vivien; Snorradóttir, Bergthóra S; Lauzon, Héléne Liette; Másson, Már

Year: 2024

Venue: Carbohydrate research

DOI: https://doi.org/10.1016/j.carres.2024.109289

Paper Optimizing N,N,N-trimethyl chitosan synthesis: A design of experiments (DoE) approach.

Nagy, Vivien; Snorradóttir, Bergthóra S; Lauzon, Hélène Liette et al. · 2024 · Carbohydrate polymers · DOI

Full title: Optimizing N,N,N-trimethyl chitosan synthesis: A design of experiments (DoE) approach.

Authors: Nagy, Vivien; Snorradóttir, Bergthóra S; Lauzon, Hélène Liette; Másson, Már

Year: 2024

Venue: Carbohydrate polymers

DOI: https://doi.org/10.1016/j.carbpol.2024.122065

Paper A quality by design approach to optimise disulfide-linked hyaluronic acid hydrogels.

Ranamalla, Saketh Reddy; Tavakoli, Shima; Porfire, Alina Silvia et al. · 2024 · Carbohydrate polymers · DOI

Full title: A quality by design approach to optimise disulfide-linked hyaluronic acid hydrogels.

Authors: Ranamalla, Saketh Reddy; Tavakoli, Shima; Porfire, Alina Silvia; Tefas, Lucia Ruxandra; Banciu, Manuela; Tomuța, Ioan; Varghese, Oommen P

Year: 2024

Venue: Carbohydrate polymers

DOI: https://doi.org/10.1016/j.carbpol.2024.122251

Paper Multivariate optimization of ulvan extraction applying Response Surface Methodology (RSM): the case of Ulva lactuca L. from Orbetello lagoon.

Zonfrillo, Beatrice; Bellumori, Maria; Digiglio, Irene et al. · 2025 · Carbohydrate polymers · DOI

Full title: Multivariate optimization of ulvan extraction applying Response Surface Methodology (RSM): the case of Ulva lactuca L. from Orbetello lagoon.

Authors: Zonfrillo, Beatrice; Bellumori, Maria; Digiglio, Irene; Innocenti, Marzia; Orlandini, Serena; Furlanetto, Sandra; Khatib, Mohamad; Papini, Alessio; Mainente, Federica; Zoccatelli, Gianni; Mulinacci, Nadia

Year: 2025

Venue: Carbohydrate polymers

DOI: https://doi.org/10.1016/j.carbpol.2025.123340

Paper Laccase mediated biodegradation of 2,4-dichlorophenol using response surface methodology.

Bhattacharya, S S; Banerjee, R · 2008 · Chemosphere · DOI

Full title: Laccase mediated biodegradation of 2,4-dichlorophenol using response surface methodology.

Authors: Bhattacharya, S S; Banerjee, R

Year: 2008

Venue: Chemosphere

DOI: https://doi.org/10.1016/j.chemosphere.2008.05.005

Paper Development of liposomes using formulation by design: Basics to recent advances.

Jain, Ankit; Hurkat, Pooja; Jain, Sanjay K · 2019 · Chemistry and physics of lipids · DOI

Full title: Development of liposomes using formulation by design: Basics to recent advances.

Authors: Jain, Ankit; Hurkat, Pooja; Jain, Sanjay K

Year: 2019

Venue: Chemistry and physics of lipids

DOI: https://doi.org/10.1016/j.chemphyslip.2019.03.017

Paper Innovative high-performance liquid chromatography method development for the screening of 19 antimalarial drugs based on a generic approach, using design of experiments, independent component analysis and design space.

Debrus, B; Lebrun, P; Kindenge, J Mbinze et al. · 2011 · Journal of chromatography. A · DOI

Full title: Innovative high-performance liquid chromatography method development for the screening of 19 antimalarial drugs based on a generic approach, using design of experiments, independent component analysis and design space.

Authors: Debrus, B; Lebrun, P; Kindenge, J Mbinze; Lecomte, F; Ceccato, A; Caliaro, G; Mbay, J Mavar Tayey; Boulanger, B; Marini, R D; Rozet, E; Hubert, Ph

Year: 2011

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2011.05.102

Paper High productivity chromatography refolding process for Hepatitis B Virus X (HBx) protein guided by statistical design of experiment studies.

Basu, Anindya; Leong, Susanna Su Jan · 2012 · Journal of chromatography. A · DOI

Full title: High productivity chromatography refolding process for Hepatitis B Virus X (HBx) protein guided by statistical design of experiment studies.

Authors: Basu, Anindya; Leong, Susanna Su Jan

Year: 2012

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2011.12.037

Paper Development and validation of a liquid chromatography-ultraviolet absorbance detection assay using derivatisation for the novel marine anticancer agent ES-285 x HCl [(2S,3R)-2-amino-3-octadecanol hydrochloride] and its pharmaceutical dosage form.

den Brok, Monique W J; Nuijen, Bastiaan; Miranda, Elena et al. · 2003 · Journal of chromatography. A · DOI

Full title: Development and validation of a liquid chromatography-ultraviolet absorbance detection assay using derivatisation for the novel marine anticancer agent ES-285 x HCl [(2S,3R)-2-amino-3-octadecanol hydrochloride] and its pharmaceutical dosage form.

Authors: den Brok, Monique W J; Nuijen, Bastiaan; Miranda, Elena; Floriano, Pablo; Munt, Simon; Manzanares, Ignacio; Beijnen, Jos H

Year: 2003

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2003.08.094

Paper Protein digestion optimization for characterization of drug-protein adducts using response surface modeling.

Switzar, L; Giera, M; Lingeman, H et al. · 2011 · Journal of chromatography. A · DOI

Full title: Protein digestion optimization for characterization of drug-protein adducts using response surface modeling.

Authors: Switzar, L; Giera, M; Lingeman, H; Irth, H; Niessen, W M A

Year: 2011

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2010.12.043

Paper Chemometric evaluation of the combined effect of temperature, pressure, and co-solvent fractions on the chiral separation of basic pharmaceuticals using actual vs set operational conditions.

Forss, Erik; Haupt, Dan; Stålberg, Olle et al. · 2017 · Journal of chromatography. A · DOI

Full title: Chemometric evaluation of the combined effect of temperature, pressure, and co-solvent fractions on the chiral separation of basic pharmaceuticals using actual vs set operational conditions.

Authors: Forss, Erik; Haupt, Dan; Stålberg, Olle; Enmark, Martin; Samuelsson, Jörgen; Fornstedt, Torgny

Year: 2017

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2017.03.077

Paper Design and optimization of a chromatographic purification process for Streptococcus pneumoniae serotype 23F capsular polysaccharide by a Design of Experiments approach.

Ji, Yu; Tian, Yang; Ahnfelt, Mattias et al. · 2014 · Journal of chromatography. A · DOI

Full title: Design and optimization of a chromatographic purification process for Streptococcus pneumoniae serotype 23F capsular polysaccharide by a Design of Experiments approach.

Authors: Ji, Yu; Tian, Yang; Ahnfelt, Mattias; Sui, Lili

Year: 2014

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2014.04.096

Paper Method development and validation for optimised separation of salicylic, acetyl salicylic and ascorbic acid in pharmaceutical formulations by hydrophilic interaction chromatography and response surface methodology.

Hatambeygi, Nader; Abedi, Ghazaleh; Talebi, Mohammad · 2011 · Journal of chromatography. A · DOI

Full title: Method development and validation for optimised separation of salicylic, acetyl salicylic and ascorbic acid in pharmaceutical formulations by hydrophilic interaction chromatography and response surface methodology.

Authors: Hatambeygi, Nader; Abedi, Ghazaleh; Talebi, Mohammad

Year: 2011

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2011.06.009

Paper Optimization of a preparative multimodal ion exchange step for purification of a potential malaria vaccine.

Paul, Jessica; Jensen, Sonja; Dukart, Arthur et al. · 2014 · Journal of chromatography. A · DOI

Full title: Optimization of a preparative multimodal ion exchange step for purification of a potential malaria vaccine.

Authors: Paul, Jessica; Jensen, Sonja; Dukart, Arthur; Cornelissen, Gesine

Year: 2014

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2014.09.029

Paper Fast-multivariate optimization of chiral separations in capillary electrophoresis: anticipative strategies.

Escuder-Gilabert, L; Martín-Biosca, Y; Sagrado, S et al. · 2014 · Journal of chromatography. A · DOI

Full title: Fast-multivariate optimization of chiral separations in capillary electrophoresis: anticipative strategies.

Authors: Escuder-Gilabert, L; Martín-Biosca, Y; Sagrado, S; Medina-Hernández, M J

Year: 2014

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2014.06.095

Paper Combination of partial least squares regression and design of experiments to model the retention of pharmaceutical compounds in supercritical fluid chromatography.

Andri, Bertyl; Dispas, Amandine; Marini, Roland Djang'Eing'a et al. · 2017 · Journal of chromatography. A · DOI

Full title: Combination of partial least squares regression and design of experiments to model the retention of pharmaceutical compounds in supercritical fluid chromatography.

Authors: Andri, Bertyl; Dispas, Amandine; Marini, Roland Djang'Eing'a; Hubert, Philippe; Sassiat, Patrick; Al Bakain, Ramia; Thiébaut, Didier; Vial, Jérôme

Year: 2017

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2017.02.030

Paper Innovative green supercritical fluid chromatography development for the determination of polar compounds.

Dispas, Amandine; Lebrun, Pierre; Sassiat, Patrick et al. · 2012 · Journal of chromatography. A · DOI

Full title: Innovative green supercritical fluid chromatography development for the determination of polar compounds.

Authors: Dispas, Amandine; Lebrun, Pierre; Sassiat, Patrick; Ziemons, Eric; Thiébaut, Didier; Vial, Jérôme; Hubert, Philippe

Year: 2012

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2012.07.043

Paper Optimizing a chromatographic three component separation: a comparison of mechanistic and empiric modeling approaches.

Osberghaus, A; Hepbildikler, S; Nath, S et al. · 2012 · Journal of chromatography. A · DOI

Full title: Optimizing a chromatographic three component separation: a comparison of mechanistic and empiric modeling approaches.

Authors: Osberghaus, A; Hepbildikler, S; Nath, S; Haindl, M; von Lieres, E; Hubbuch, J

Year: 2012

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2012.03.029

Paper Effects of resin ligand density on yield and impurity clearance in preparative cation exchange chromatography. II. Process characterization.

Fogle, Jace; Persson, Josefine · 2012 · Journal of chromatography. A · DOI

Full title: Effects of resin ligand density on yield and impurity clearance in preparative cation exchange chromatography. II. Process characterization.

Authors: Fogle, Jace; Persson, Josefine

Year: 2012

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2011.12.049

Paper The development and qualification of liquid adsorption chromatography for poloxamer 188 characterization.

Chen, Wei; Ross, Alfred; Steinhuber, Bernd et al. · 2021 · Journal of chromatography. A · DOI

Full title: The development and qualification of liquid adsorption chromatography for poloxamer 188 characterization.

Authors: Chen, Wei; Ross, Alfred; Steinhuber, Bernd; Hoffmann, Gabriel; Oltra, Nuria Sancho; Ravuri, Satya Krishna Kishore; Bond, Steven; Bell, Christian; Kopf, Robert

Year: 2021

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2021.462353

Paper A simultaneous determination of related substances by high performance liquid chromatography in a drug product using quality by design approach.

Tol, Trupti; Kadam, Nilesh; Raotole, Nilesh et al. · 2016 · Journal of chromatography. A · DOI

Full title: A simultaneous determination of related substances by high performance liquid chromatography in a drug product using quality by design approach.

Authors: Tol, Trupti; Kadam, Nilesh; Raotole, Nilesh; Desai, Anita; Samanta, Gautam

Year: 2016

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2015.12.080

Paper High throughput process development workflow with advanced decision-support for antibody purification.

Stamatis, Christos; Goldrick, Stephen; Gruber, David et al. · 2019 · Journal of chromatography. A · DOI

Full title: High throughput process development workflow with advanced decision-support for antibody purification.

Authors: Stamatis, Christos; Goldrick, Stephen; Gruber, David; Turner, Richard; Titchener-Hooker, Nigel J; Farid, Suzanne S

Year: 2019

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2019.03.005

Paper Monitoring leachables from single-use bioreactor bags for mammalian cell culture by dispersive liquid-liquid microextraction followed by ultra high performance liquid chromatography quadrupole time of flight mass spectrometry.

Dorival-García, N; Bones, J · 2017 · Journal of chromatography. A · DOI

Full title: Monitoring leachables from single-use bioreactor bags for mammalian cell culture by dispersive liquid-liquid microextraction followed by ultra high performance liquid chromatography quadrupole time of flight mass spectrometry.

Authors: Dorival-García, N; Bones, J

Year: 2017

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2017.06.077

Paper SPE-LC-MS/MS optimisation using response surface methodology for quantification of pharmaceuticals, pesticides and organic UV filters included in water protection guidelines.

Gorito, Ana M; Mota, Beatriz R; Silva, Adrián M T et al. · 2025 · Journal of chromatography. A · DOI

Full title: SPE-LC-MS/MS optimisation using response surface methodology for quantification of pharmaceuticals, pesticides and organic UV filters included in water protection guidelines.

Authors: Gorito, Ana M; Mota, Beatriz R; Silva, Adrián M T; Ribeiro, Ana R L

Year: 2025

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2025.466052

Paper The application of design of experiments and artificial neural networks in the evaluation of the impact of acidic conditions on cloud point extraction.

Sznek, Bartosz; Czyrski, Andrzej · 2025 · Journal of chromatography. A · DOI

Full title: The application of design of experiments and artificial neural networks in the evaluation of the impact of acidic conditions on cloud point extraction.

Authors: Sznek, Bartosz; Czyrski, Andrzej

Year: 2025

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2025.465686

Paper Optimization and troubleshooting of preparative liquid chromatography using statistical design of experiments: Four small-molecule case studies.

Hochdorfer, Teri Shanklin; Wang, Ke · 2022 · Journal of chromatography. A · DOI

Full title: Optimization and troubleshooting of preparative liquid chromatography using statistical design of experiments: Four small-molecule case studies.

Authors: Hochdorfer, Teri Shanklin; Wang, Ke

Year: 2022

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2022.463212

Paper Evaluation of solvent systems for optimized extractables studies of single use bioprocessing solutions.

Dorival-García, Noemí; Bones, Jonathan · 2017 · Journal of chromatography. A · DOI

Full title: Evaluation of solvent systems for optimized extractables studies of single use bioprocessing solutions.

Authors: Dorival-García, Noemí; Bones, Jonathan

Year: 2017

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2017.06.066

Paper Streamlining cation exchange chromatography process development for therapeutic monoclonal antibody purification.

Lau, Wing Yee; Mi, Xue; Dumont, Alex et al. · 2025 · Journal of chromatography. A · DOI

Full title: Streamlining cation exchange chromatography process development for therapeutic monoclonal antibody purification.

Authors: Lau, Wing Yee; Mi, Xue; Dumont, Alex; Yang, Lihua

Year: 2025

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2025.466391

Paper Application of design of experiments to optimize the separation of lipid-related compounds in supercritical fluid chromatography-mass spectrometry.

Kazmouz, Muhamad Yahia; Mayer, Mátyás; Felinger, Attila · 2026 · Journal of chromatography. A · DOI

Full title: Application of design of experiments to optimize the separation of lipid-related compounds in supercritical fluid chromatography-mass spectrometry.

Authors: Kazmouz, Muhamad Yahia; Mayer, Mátyás; Felinger, Attila

Year: 2026

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2025.466567

Paper Optimization of peptide-plasmid DNA vectors formulation for gene delivery in cancer therapy exploring design of experiments.

Sousa, Ângela; Almeida, Ana M; Faria, Rúben et al. · 2019 · Colloids and surfaces. B, Biointerfaces · DOI

Full title: Optimization of peptide-plasmid DNA vectors formulation for gene delivery in cancer therapy exploring design of experiments.

Authors: Sousa, Ângela; Almeida, Ana M; Faria, Rúben; Konate, Karidia; Boisguerin, Prisca; Queiroz, João A; Costa, Diana

Year: 2019

Venue: Colloids and surfaces. B, Biointerfaces

DOI: https://doi.org/10.1016/j.colsurfb.2019.110417

Paper Bioremediation of chlorpyrifos contaminated soil by two phase bioslurry reactor: Processes evaluation and optimization by Taguchi's design of experimental (DOE) methodology.

Pant, Apourv; Rai, J P N · 2018 · Ecotoxicology and environmental safety · DOI

Full title: Bioremediation of chlorpyrifos contaminated soil by two phase bioslurry reactor: Processes evaluation and optimization by Taguchi's design of experimental (DOE) methodology.

Authors: Pant, Apourv; Rai, J P N

Year: 2018

Venue: Ecotoxicology and environmental safety

DOI: https://doi.org/10.1016/j.ecoenv.2017.12.052

Paper Enhanced production of dimethyl phthalate-degrading strain Bacillus sp. QD14 by optimizing fermentation medium

Mo Jixian; Zhigang Wang; Weihui Xu et al. · 2015 · DOI

Full title: Enhanced production of dimethyl phthalate-degrading strain Bacillus sp. QD14 by optimizing fermentation medium

Authors: Mo Jixian; Zhigang Wang; Weihui Xu; Li Shanshan; Yu Zhidan

Year: 2015

DOI: https://doi.org/10.1016/j.ejbt.2015.03.013

Paper Key reaction components affect the kinetics and performance robustness of cell-free protein synthesis reactions.

Banks, Alice M; Whitfield, Colette J; Brown, Steven R et al. · 2022 · Computational and structural biotechnology journal · DOI

Full title: Key reaction components affect the kinetics and performance robustness of cell-free protein synthesis reactions.

Authors: Banks, Alice M; Whitfield, Colette J; Brown, Steven R; Fulton, David A; Goodchild, Sarah A; Grant, Christopher; Love, John; Lendrem, Dennis W; Fieldsend, Jonathan E; Howard, Thomas P

Year: 2022

Venue: Computational and structural biotechnology journal

DOI: https://doi.org/10.1016/j.csbj.2021.12.013

Paper Application of experimental design and derivative spectrophotometry methods in optimization and analysis of biosorption of binary mixtures of basic dyes from aqueous solutions.

Asfaram, Arash; Ghaedi, Mehrorang; Ghezelbash, Gholam Reza et al. · 2017 · Ecotoxicology and environmental safety · DOI

Full title: Application of experimental design and derivative spectrophotometry methods in optimization and analysis of biosorption of binary mixtures of basic dyes from aqueous solutions.

Authors: Asfaram, Arash; Ghaedi, Mehrorang; Ghezelbash, Gholam Reza; Pepe, Francesco

Year: 2017

Venue: Ecotoxicology and environmental safety

DOI: https://doi.org/10.1016/j.ecoenv.2017.01.043

Paper Lost in space: design of experiments and scientific exploration in a Hogarth Universe.

Lendrem, Dennis W; Lendrem, B Clare; Woods, David et al. · 2015 · Drug discovery today · DOI

Full title: Lost in space: design of experiments and scientific exploration in a Hogarth Universe.

Authors: Lendrem, Dennis W; Lendrem, B Clare; Woods, David; Rowland-Jones, Ruth; Burke, Matthew; Chatfield, Marion; Isaacs, John D; Owen, Martin R

Year: 2015

Venue: Drug discovery today

DOI: https://doi.org/10.1016/j.drudis.2015.09.015

Paper Image dataset: Optimizing growth of nonembryogenic citrus tissue cultures using response surface methodology.

Niedz, Randall P; Wynn, Eldridge T · 2024 · Data in brief · DOI

Full title: Image dataset: Optimizing growth of nonembryogenic citrus tissue cultures using response surface methodology.

Authors: Niedz, Randall P; Wynn, Eldridge T

Year: 2024

Venue: Data in brief

DOI: https://doi.org/10.1016/j.dib.2024.111091

Paper Quality by design - Spray drying of insulin intended for inhalation.

Maltesen, Morten Jonas; Bjerregaard, Simon; Hovgaard, Lars et al. · 2008 · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · DOI

Full title: Quality by design - Spray drying of insulin intended for inhalation.

Authors: Maltesen, Morten Jonas; Bjerregaard, Simon; Hovgaard, Lars; Havelund, Svend; van de Weert, Marco

Year: 2008

Venue: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

DOI: https://doi.org/10.1016/j.ejpb.2008.07.015

Paper Predicting the influence of liposomal lipid composition on liposome size, zeta potential and liposome-induced dendritic cell maturation using a design of experiments approach.

Soema, Peter C; Willems, Geert-Jan; Jiskoot, Wim et al. · 2015 · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · DOI

Full title: Predicting the influence of liposomal lipid composition on liposome size, zeta potential and liposome-induced dendritic cell maturation using a design of experiments approach.

Authors: Soema, Peter C; Willems, Geert-Jan; Jiskoot, Wim; Amorij, Jean-Pierre; Kersten, Gideon F

Year: 2015

Venue: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

DOI: https://doi.org/10.1016/j.ejpb.2015.06.026

Paper Evaluation of in-line spatial filter velocimetry as PAT monitoring tool for particle growth during fluid bed granulation.

Burggraeve, A; Van Den Kerkhof, T; Hellings, M et al. · 2010 · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · DOI

Full title: Evaluation of in-line spatial filter velocimetry as PAT monitoring tool for particle growth during fluid bed granulation.

Authors: Burggraeve, A; Van Den Kerkhof, T; Hellings, M; Remon, J P; Vervaet, C; De Beer, T

Year: 2010

Venue: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

DOI: https://doi.org/10.1016/j.ejpb.2010.06.001

Paper Global Sensitivity Analysis as Good Modelling Practices tool for the identification of the most influential process parameters of the primary drying step during freeze-drying.

Van Bockstal, Pieter-Jan; Mortier, Séverine Thérèse F C; Corver, Jos et al. · 2018 · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · DOI

Full title: Global Sensitivity Analysis as Good Modelling Practices tool for the identification of the most influential process parameters of the primary drying step during freeze-drying.

Authors: Van Bockstal, Pieter-Jan; Mortier, Séverine Thérèse F C; Corver, Jos; Nopens, Ingmar; Gernaey, Krist V; De Beer, Thomas

Year: 2018

Venue: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

DOI: https://doi.org/10.1016/j.ejpb.2017.12.006

Paper Process optimization by use of design of experiments: Application for liposomalization of FK506.

Toyota, Hiroyasu; Asai, Tomohiro; Oku, Naoto · 2017 · European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · DOI

Full title: Process optimization by use of design of experiments: Application for liposomalization of FK506.

Authors: Toyota, Hiroyasu; Asai, Tomohiro; Oku, Naoto

Year: 2017

Venue: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

DOI: https://doi.org/10.1016/j.ejps.2017.03.007

Paper Quality by design in pharmaceutical manufacturing: A systematic review of current status, challenges and future perspectives.

Grangeia, Helena Bigares; Silva, Cláudia; Simões, Sérgio Paulo et al. · 2020 · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · DOI

Full title: Quality by design in pharmaceutical manufacturing: A systematic review of current status, challenges and future perspectives.

Authors: Grangeia, Helena Bigares; Silva, Cláudia; Simões, Sérgio Paulo; Reis, Marco S

Year: 2020

Venue: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

DOI: https://doi.org/10.1016/j.ejpb.2019.12.007

Paper Estimation of design space for an extrusion-spheronization process using response surface methodology and artificial neural network modelling.

Sovány, Tamás; Tislér, Zsófia; Kristó, Katalin et al. · 2016 · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · DOI

Full title: Estimation of design space for an extrusion-spheronization process using response surface methodology and artificial neural network modelling.

Authors: Sovány, Tamás; Tislér, Zsófia; Kristó, Katalin; Kelemen, András; Regdon, Géza

Year: 2016

Venue: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

DOI: https://doi.org/10.1016/j.ejpb.2016.05.009

Paper Advancing forced degradation studies: Design of experiments for enhanced structure-function relationship analysis in biotherapeutics.

Kronsbein, Klaus; Nold, Verena; Böhrer, Armin et al. · 2025 · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · DOI

Full title: Advancing forced degradation studies: Design of experiments for enhanced structure-function relationship analysis in biotherapeutics.

Authors: Kronsbein, Klaus; Nold, Verena; Böhrer, Armin; Presser, Beate; Gaissmaier, Tanja; Schindowski, Katharina; Mizaikoff, Boris; Krattenmacher, Florian

Year: 2025

Venue: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

DOI: https://doi.org/10.1016/j.ejpb.2025.114787

Paper Improving extracellular vesicles production through a Bayesian optimization-based experimental design.

Bader, Johannes; Narayanan, Harini; Arosio, Paolo et al. · 2023 · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · DOI

Full title: Improving extracellular vesicles production through a Bayesian optimization-based experimental design.

Authors: Bader, Johannes; Narayanan, Harini; Arosio, Paolo; Leroux, Jean-Christophe

Year: 2023

Venue: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

DOI: https://doi.org/10.1016/j.ejpb.2022.12.004

Paper Design-of-experiments based development and in vitro evaluation of a cationic lipid-based triple adjuvanted subunit pertussis vaccine.

Mandava, Tavonga T; Gerdts, Volker; Ejlali, Maryam et al. · 2025 · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · DOI

Full title: Design-of-experiments based development and in vitro evaluation of a cationic lipid-based triple adjuvanted subunit pertussis vaccine.

Authors: Mandava, Tavonga T; Gerdts, Volker; Ejlali, Maryam; Wasan, Ellen K

Year: 2025

Venue: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

DOI: https://doi.org/10.1016/j.ejpb.2025.114890

Paper The influence of cetomacrogol ointment processing on structure: A definitive screening design.

van Heugten, A J P; Braal, C L; Versluijs-Helder, M et al. · 2017 · European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · DOI

Full title: The influence of cetomacrogol ointment processing on structure: A definitive screening design.

Authors: van Heugten, A J P; Braal, C L; Versluijs-Helder, M; Vromans, H

Year: 2017

Venue: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

DOI: https://doi.org/10.1016/j.ejps.2016.12.029

Paper Design of experiments approach for the development of a validated method to determine the exenatide content in poly(lactide-co-glycolide) microspheres.

Sheikhi, Mojgan; Sharifzadeh, Mohammad; Hennink, Wim E et al. · 2023 · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · DOI

Full title: Design of experiments approach for the development of a validated method to determine the exenatide content in poly(lactide-co-glycolide) microspheres.

Authors: Sheikhi, Mojgan; Sharifzadeh, Mohammad; Hennink, Wim E; Firoozpour, Loghman; Hajimahmoodi, Mannan; Khoshayand, Mohammad Reza; Shirangi, Mehrnoosh

Year: 2023

Venue: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

DOI: https://doi.org/10.1016/j.ejpb.2023.09.016

Paper Optimizing spray-dried liposomes for pulmonary delivery: impact of lipids composition and of drying parameters using experimental design.

Bya, Laure-Anne; Dinh, Tuan Nghia; Penoy, Noémie et al. · 2026 · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · DOI

Full title: Optimizing spray-dried liposomes for pulmonary delivery: impact of lipids composition and of drying parameters using experimental design.

Authors: Bya, Laure-Anne; Dinh, Tuan Nghia; Penoy, Noémie; Sacré, Pierre-Yves; Bottero, Benedetta; Cataldo, Didier; Hendrickx, Erika; Conrard, Louise; Evrard, Brigitte; Piel, Géraldine; Lechanteur, Anna

Year: 2026

Venue: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

DOI: https://doi.org/10.1016/j.ejpb.2026.115035

Paper Biodegradable Electrospun Nanofibers: A New Approach For Rhinosinusitis Treatment.

Rivelli, Graziella Gomes; Perez, André Coura; Silva, Pedro Henrique Reis et al. · 2021 · European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · DOI

Full title: Biodegradable Electrospun Nanofibers: A New Approach For Rhinosinusitis Treatment.

Authors: Rivelli, Graziella Gomes; Perez, André Coura; Silva, Pedro Henrique Reis; Gomes, Elionai Cassiana de Lima; Moreira, Carolina Paula de Souza; Tamashiro, Edwin; Valera, Fabiana Cardoso Pereira; Anselmo-Lima, Wilma Terezinha; Pianetti, Gérson Antônio; Silva-Cunha, Armando

Year: 2021

Venue: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

DOI: https://doi.org/10.1016/j.ejps.2021.105852

Paper Human intestinal fluid factors affecting intestinal drug permeation in vitro.

Riethorst, Danny; Brouwers, Joachim; Motmans, Jens et al. · 2018 · European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · DOI

Full title: Human intestinal fluid factors affecting intestinal drug permeation in vitro.

Authors: Riethorst, Danny; Brouwers, Joachim; Motmans, Jens; Augustijns, Patrick

Year: 2018

Venue: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

DOI: https://doi.org/10.1016/j.ejps.2018.06.007

Paper Designing the design of experiments (DOE) – An investigation on the influence of different factorial designs on the characterization of complex systems

Janković, A.; Chaudhary, Gaurav; Goia, Francesco · 2021 · Energy and Buildings · DOI

Full title: Designing the design of experiments (DOE) – An investigation on the influence of different factorial designs on the characterization of complex systems

Authors: Janković, A.; Chaudhary, Gaurav; Goia, Francesco

Year: 2021

Venue: Energy and Buildings

DOI: https://doi.org/10.1016/j.enbuild.2021.111298

Paper Miniaturized screening and performance prediction of tailored subcutaneous extended-release formulations for preclinical in vivo studies.

Block, Marco; Sieger, Peter; Truenkle, Cornelius et al. · 2024 · European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · DOI

Full title: Miniaturized screening and performance prediction of tailored subcutaneous extended-release formulations for preclinical in vivo studies.

Authors: Block, Marco; Sieger, Peter; Truenkle, Cornelius; Saal, Christoph; Simon, Roman; Truebenbach, Ines

Year: 2024

Venue: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

DOI: https://doi.org/10.1016/j.ejps.2024.106733

Paper Predicting and validating surfactant performance in nanocrystal stabilization using multi-criteria decision analysis and solubility parameter modeling.

Ndongwe, Tanaka; Makoni, Pedzisai A; Matlou, Gauta G et al. · 2026 · European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · DOI

Full title: Predicting and validating surfactant performance in nanocrystal stabilization using multi-criteria decision analysis and solubility parameter modeling.

Authors: Ndongwe, Tanaka; Makoni, Pedzisai A; Matlou, Gauta G; Nhlapo, Toitoi A; Corvis, Yohann; Siwe-Noundou, Xavier; Witika, Bwalya A

Year: 2026

Venue: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

DOI: https://doi.org/10.1016/j.ejps.2026.107479

Paper Optimising functional properties during preparation of cowpea protein concentrate.

Mune Mune, Martin Alain; Minka, Samuel René; Mbome, Israël Lape · 2014 · Food chemistry · DOI

Full title: Optimising functional properties during preparation of cowpea protein concentrate.

Authors: Mune Mune, Martin Alain; Minka, Samuel René; Mbome, Israël Lape

Year: 2014

Venue: Food chemistry

DOI: https://doi.org/10.1016/j.foodchem.2013.12.108

Paper Biobleaching of loblolly pine kraft pulp with Trametes trogii culture fluids followed by a peroxide stage. Application of Doehlert experimental design to evaluate process parameters.

V. Ré; L. Papinutti; F. Forchiassin et al. · 2010 · DOI

Full title: Biobleaching of loblolly pine kraft pulp with Trametes trogii culture fluids followed by a peroxide stage. Application of Doehlert experimental design to evaluate process parameters.

Authors: V. Ré; L. Papinutti; F. Forchiassin; L. Levin

Year: 2010

DOI: https://doi.org/10.1016/j.enzmictec.2009.12.006

Paper Efficient in vitro megakaryocyte maturation using cytokine cocktails optimized by statistical experimental design.

Cortin, Valérie; Garnier, Alain; Pineault, Nicolas et al. · 2005 · Experimental hematology · DOI

Full title: Efficient in vitro megakaryocyte maturation using cytokine cocktails optimized by statistical experimental design.

Authors: Cortin, Valérie; Garnier, Alain; Pineault, Nicolas; Lemieux, Réal; Boyer, Lucie; Proulx, Chantal

Year: 2005

Venue: Experimental hematology

DOI: https://doi.org/10.1016/j.exphem.2005.06.020

Paper Comparing design of experiments and optimal experimental design techniques for modelling the microbial growth rate under static environmental conditions.

Akkermans, Simen; Nimmegeers, Philippe; Van Impe, Jan F · 2018 · Food microbiology · DOI

Full title: Comparing design of experiments and optimal experimental design techniques for modelling the microbial growth rate under static environmental conditions.

Authors: Akkermans, Simen; Nimmegeers, Philippe; Van Impe, Jan F

Year: 2018

Venue: Food microbiology

DOI: https://doi.org/10.1016/j.fm.2018.05.010

Paper Evaluation of cysteine ethyl ester as efficient inducer for glutathione overproduction in Saccharomyces spp.

Lorenz, Eric; Schmacht, Maximilian; Senz, Martin · 2016 · Enzyme and microbial technology · DOI

Full title: Evaluation of cysteine ethyl ester as efficient inducer for glutathione overproduction in Saccharomyces spp.

Authors: Lorenz, Eric; Schmacht, Maximilian; Senz, Martin

Year: 2016

Venue: Enzyme and microbial technology

DOI: https://doi.org/10.1016/j.enzmictec.2016.08.004

Paper Production of xylo-oligosaccharides (XOS) of tailored degree of polymerization from acetylated xylans through modelling of enzymatic hydrolysis.

Fuso, Andrea; Rosso, Franco; Rosso, Ginevra et al. · 2022 · Food research international (Ottawa, Ont.) · DOI

Full title: Production of xylo-oligosaccharides (XOS) of tailored degree of polymerization from acetylated xylans through modelling of enzymatic hydrolysis.

Authors: Fuso, Andrea; Rosso, Franco; Rosso, Ginevra; Risso, Davide; Manera, Ileana; Caligiani, Augusta

Year: 2022

Venue: Food research international (Ottawa, Ont.)

DOI: https://doi.org/10.1016/j.foodres.2022.112019

Paper Inactivation of Bacillus sporothermodurans spores by nisin and temperature studied by design of experiments in water and milk.

Aouadhi, Chedia; Rouissi, Zeineb; Mejri, Slah et al. · 2014 · Food microbiology · DOI

Full title: Inactivation of Bacillus sporothermodurans spores by nisin and temperature studied by design of experiments in water and milk.

Authors: Aouadhi, Chedia; Rouissi, Zeineb; Mejri, Slah; Maaroufi, Abderrazak

Year: 2014

Venue: Food microbiology

DOI: https://doi.org/10.1016/j.fm.2013.10.005

Paper Release of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from milk protein isolate (MPI) during enzymatic hydrolysis.

Nongonierma, Alice B; Mazzocchi, Caterina; Paolella, Sara et al. · 2017 · Food research international (Ottawa, Ont.) · DOI

Full title: Release of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from milk protein isolate (MPI) during enzymatic hydrolysis.

Authors: Nongonierma, Alice B; Mazzocchi, Caterina; Paolella, Sara; FitzGerald, Richard J

Year: 2017

Venue: Food research international (Ottawa, Ont.)

DOI: https://doi.org/10.1016/j.foodres.2017.02.004

Paper Development of a multiplex forensic identity panel for massively parallel sequencing and its systematic optimization using design of experiments.

Ganschow, Sebastian; Silvery, Janine; Tiemann, Carsten · 2019 · Forensic science international. Genetics · DOI

Full title: Development of a multiplex forensic identity panel for massively parallel sequencing and its systematic optimization using design of experiments.

Authors: Ganschow, Sebastian; Silvery, Janine; Tiemann, Carsten

Year: 2019

Venue: Forensic science international. Genetics

DOI: https://doi.org/10.1016/j.fsigen.2018.11.023

Paper Optimization of culture conditions for Mpt64 synthetic gene expression in Escherichia coli BL21 (DE3) using surface response methodology

S. Kusuma; I. Parwati; T. Rostinawati et al. · 2019 · Heliyon · DOI

Full title: Optimization of culture conditions for Mpt64 synthetic gene expression in Escherichia coli BL21 (DE3) using surface response methodology

Authors: S. Kusuma; I. Parwati; T. Rostinawati; M. Yusuf; M. Fadhlillah; R. Ahyudanari; Y. Rukayadi; T. Subroto

Year: 2019

Venue: Heliyon

DOI: https://doi.org/10.1016/j.heliyon.2019.e02741

Paper Systematic optimization of culture media for maintenance of human induced pluripotent stem cells using the response surface methodology.

Mousavi Mirkalaei, Seyedmilad; Farivar, Shirin · 2024 · Heliyon · DOI

Full title: Systematic optimization of culture media for maintenance of human induced pluripotent stem cells using the response surface methodology.

Authors: Mousavi Mirkalaei, Seyedmilad; Farivar, Shirin

Year: 2024

Venue: Heliyon

DOI: https://doi.org/10.1016/j.heliyon.2024.e32558

Paper Removal of malachite green by polyacrylamide-g-chitosan γ-Fe2O3 nanocomposite-an application of central composite design

I. Hasan; D. Bhatia; S. Walia et al. · 2020 · Groundwater for Sustainable Development · DOI

Full title: Removal of malachite green by polyacrylamide-g-chitosan γ-Fe2O3 nanocomposite-an application of central composite design

Authors: I. Hasan; D. Bhatia; S. Walia; Parshottam Singh

Year: 2020

Venue: Groundwater for Sustainable Development

DOI: https://doi.org/10.1016/j.gsd.2020.100378

Paper Traditional or adaptive design of experiments? A pilot-scale comparison on wood delignification.

Rummukainen, Hannu; Hörhammer, Hanna; Kuusela, Pirkko et al. · 2024 · Heliyon · DOI

Full title: Traditional or adaptive design of experiments? A pilot-scale comparison on wood delignification.

Authors: Rummukainen, Hannu; Hörhammer, Hanna; Kuusela, Pirkko; Kilpi, Jorma; Sirviö, Jari; Mäkelä, Mikko

Year: 2024

Venue: Heliyon

DOI: https://doi.org/10.1016/j.heliyon.2024.e24484

Paper Optimization and characterization of PHA from isolate Pannonibacter phragmitetus ERC8 using glycerol waste.

Ray, Sanket; Prajapati, Vimal; Patel, Kamlesh et al. · 2016 · International journal of biological macromolecules · DOI

Full title: Optimization and characterization of PHA from isolate Pannonibacter phragmitetus ERC8 using glycerol waste.

Authors: Ray, Sanket; Prajapati, Vimal; Patel, Kamlesh; Trivedi, Ujjval

Year: 2016

Venue: International journal of biological macromolecules

DOI: https://doi.org/10.1016/j.ijbiomac.2016.02.002

Paper Statistical optimization of pullulan production from Asian palm kernel and evaluation of its properties.

Sugumaran, K R; Shobana, P; Mohan Balaji, P et al. · 2014 · International journal of biological macromolecules · DOI

Full title: Statistical optimization of pullulan production from Asian palm kernel and evaluation of its properties.

Authors: Sugumaran, K R; Shobana, P; Mohan Balaji, P; Ponnusami, V; Gowdhaman, D

Year: 2014

Venue: International journal of biological macromolecules

DOI: https://doi.org/10.1016/j.ijbiomac.2014.02.045

Paper Cd2+ removal efficiency of activated carbon from Prosopis juliflora: Optimization of preparation parameters by the Box-Behnken Design of Response Surface Methodology.

Chintokoma, Gilbert C; Chebude, Yonas; Kassahun, Shimelis K · 2024 · Heliyon · DOI

Full title: Cd2+ removal efficiency of activated carbon from Prosopis juliflora: Optimization of preparation parameters by the Box-Behnken Design of Response Surface Methodology.

Authors: Chintokoma, Gilbert C; Chebude, Yonas; Kassahun, Shimelis K

Year: 2024

Venue: Heliyon

DOI: https://doi.org/10.1016/j.heliyon.2024.e31357

Paper Optimization of in vitro refolding conditions of recombinant Lepidium draba peroxidase using design of experiments.

Fattahian, Yaser; Riahi-Madvar, Ali; Mirzaee, Reza et al. · 2018 · International journal of biological macromolecules · DOI

Full title: Optimization of in vitro refolding conditions of recombinant Lepidium draba peroxidase using design of experiments.

Authors: Fattahian, Yaser; Riahi-Madvar, Ali; Mirzaee, Reza; Torkzadeh-Mahani, Masoud; Asadikaram, Gholamreza; Sargazi, Ghasem

Year: 2018

Venue: International journal of biological macromolecules

DOI: https://doi.org/10.1016/j.ijbiomac.2018.06.122

Paper Extraction and antioxidant activities of polysaccharides from roots of Arctium lappa L.

Yuanyuan Jiang; Jun Yu; Yabo Li et al. · 2019 · International Journal of Biological Macromolecules · DOI

Full title: Extraction and antioxidant activities of polysaccharides from roots of Arctium lappa L.

Authors: Yuanyuan Jiang; Jun Yu; Yabo Li; Long Wang; Liang Hu; Li Zhang; Yonghong Zhou

Year: 2019

Venue: International Journal of Biological Macromolecules

DOI: https://doi.org/10.1016/j.ijbiomac.2018.11.087

Paper Optimization of recombinant hexaoligochitin-producing chitinase production with response surface methodology.

Liu, Chao-Lin; Lin, Tsung-Han; Juang, Ruey-Shin · 2013 · International journal of biological macromolecules · DOI

Full title: Optimization of recombinant hexaoligochitin-producing chitinase production with response surface methodology.

Authors: Liu, Chao-Lin; Lin, Tsung-Han; Juang, Ruey-Shin

Year: 2013

Venue: International journal of biological macromolecules

DOI: https://doi.org/10.1016/j.ijbiomac.2013.09.048

Paper Biological treatment of lignocellulosic biomass by Chaetomium globosporum: Process derivation and improved biogas production.

Yadav, Monika; Singh, Amit; Balan, Venkatesh et al. · 2019 · International journal of biological macromolecules · DOI

Full title: Biological treatment of lignocellulosic biomass by Chaetomium globosporum: Process derivation and improved biogas production.

Authors: Yadav, Monika; Singh, Amit; Balan, Venkatesh; Pareek, Nidhi; Vivekanand, Vivekanand

Year: 2019

Venue: International journal of biological macromolecules

DOI: https://doi.org/10.1016/j.ijbiomac.2019.01.118

Paper DOE-based process optimization for development of efficient methods for purification of recombinant hepatitis B surface antigen from Pichia pastoris feedstock using Capto adhere resin.

Moazami Goodarzi, Maryam; Jalalirad, Reza; Doroud, Delaram et al. · 2024 · Heliyon · DOI

Full title: DOE-based process optimization for development of efficient methods for purification of recombinant hepatitis B surface antigen from Pichia pastoris feedstock using Capto adhere resin.

Authors: Moazami Goodarzi, Maryam; Jalalirad, Reza; Doroud, Delaram; Hozouri, Hamidreza; Aghasadeghi, Mohammad Reza

Year: 2024

Venue: Heliyon

DOI: https://doi.org/10.1016/j.heliyon.2024.e35124

Paper Systematic optimization of histidine-tagged enhanced green fluorescent protein (His-EGFP) purification using packed bed immobilized metal affinity chromatography: A multistage design of experiments approach.

Chou, Yen-Hsun; Hanh, Nguyen The Duc; Panjapornpon, Chanin et al. · 2025 · International journal of biological macromolecules · DOI

Full title: Systematic optimization of histidine-tagged enhanced green fluorescent protein (His-EGFP) purification using packed bed immobilized metal affinity chromatography: A multistage design of experiments approach.

Authors: Chou, Yen-Hsun; Hanh, Nguyen The Duc; Panjapornpon, Chanin; Charoenchaitrakool, Manop; Sudsakorn, Kandis; Jitapunkul, Kulpavee; Chiu, Chen-Yaw; Liu, Bing-Lan; Chen, Kuei-Hsiang; Chang, Yu-Kaung

Year: 2025

Venue: International journal of biological macromolecules

DOI: https://doi.org/10.1016/j.ijbiomac.2025.147325

Paper Optimization for simultaneous enhancement of biobutanol and biohydrogen production

Santoshnambi Yadav; Vaishali Singh; C. Mahata et al. · 2020 · DOI

Full title: Optimization for simultaneous enhancement of biobutanol and biohydrogen production

Authors: Santoshnambi Yadav; Vaishali Singh; C. Mahata; D. Das

Year: 2020

DOI: https://doi.org/10.1016/j.ijhydene.2020.10.267

Paper Extraction, characterization and biological activity of sulfated polysaccharides from seaweed Dictyopteris divaricata.

Yinxin Cui; Xin Liu; Shufang Li et al. · 2018 · International Journal of Biological Macromolecules · DOI

Full title: Extraction, characterization and biological activity of sulfated polysaccharides from seaweed Dictyopteris divaricata.

Authors: Yinxin Cui; Xin Liu; Shufang Li; Limin Hao; Juan Du; Dahai Gao; Qiao-zhen Kang; Jike Lu

Year: 2018

Venue: International Journal of Biological Macromolecules

DOI: https://doi.org/10.1016/j.ijbiomac.2018.05.134

Paper Optimization of process using carboxymethyl chitosan for the removal of mixed heavy metals from aqueous streams.

Kavitha, Edward; Kedia, Ritika; Babaria, Nikhil et al. · 2020 · International journal of biological macromolecules · DOI

Full title: Optimization of process using carboxymethyl chitosan for the removal of mixed heavy metals from aqueous streams.

Authors: Kavitha, Edward; Kedia, Ritika; Babaria, Nikhil; Prabhakar, Sivaraman; Rajesh, Mathur P

Year: 2020

Venue: International journal of biological macromolecules

DOI: https://doi.org/10.1016/j.ijbiomac.2020.01.066

Paper Formulation optimization of itraconazole loaded PEGylated liposomes for parenteral administration by using design of experiments.

Curić, Anamarija; Reul, Regina; Möschwitzer, Jan et al. · 2013 · International journal of pharmaceutics · DOI

Full title: Formulation optimization of itraconazole loaded PEGylated liposomes for parenteral administration by using design of experiments.

Authors: Curić, Anamarija; Reul, Regina; Möschwitzer, Jan; Fricker, Gert

Year: 2013

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2013.03.029

Paper Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules.

Mehta, Samata; De Beer, Thomas; Remon, Jean Paul et al. · 2012 · International journal of pharmaceutics · DOI

Full title: Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules.

Authors: Mehta, Samata; De Beer, Thomas; Remon, Jean Paul; Vervaet, Chris

Year: 2012

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2011.11.017

Paper Production and optimization of high grade cellulase from waste date seeds by Cellulomonas uda NCIM 2353 for biohydrogen production

R. Swathy; K. Rambabu; F. Banat et al. · 2020 · International journal of hydrogen energy · DOI

Full title: Production and optimization of high grade cellulase from waste date seeds by Cellulomonas uda NCIM 2353 for biohydrogen production

Authors: R. Swathy; K. Rambabu; F. Banat; Shih‐Hsin Ho; D. Chu; P. Show

Year: 2020

Venue: International journal of hydrogen energy

DOI: https://doi.org/10.1016/j.ijhydene.2019.06.171

Paper Optimization of a pharmaceutical tablet formulation based on a design space approach and using vibrational spectroscopy as PAT tool.

Chavez, Pierre-François; Lebrun, Pierre; Sacré, Pierre-Yves et al. · 2015 · International journal of pharmaceutics · DOI

Full title: Optimization of a pharmaceutical tablet formulation based on a design space approach and using vibrational spectroscopy as PAT tool.

Authors: Chavez, Pierre-François; Lebrun, Pierre; Sacré, Pierre-Yves; De Bleye, Charlotte; Netchacovitch, Lauranne; Cuypers, Serge; Mantanus, Jérôme; Motte, Henri; Schubert, Martin; Evrard, Brigitte; Hubert, Philippe; Ziemons, Eric

Year: 2015

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2015.03.025

Paper Evaluating the effects of buffer conditions and extremolytes on thermostability of granulocyte colony-stimulating factor using high-throughput screening combined with design of experiments.

Ablinger, Elisabeth; Hellweger, Monika; Leitgeb, Stefan et al. · 2012 · International journal of pharmaceutics · DOI

Full title: Evaluating the effects of buffer conditions and extremolytes on thermostability of granulocyte colony-stimulating factor using high-throughput screening combined with design of experiments.

Authors: Ablinger, Elisabeth; Hellweger, Monika; Leitgeb, Stefan; Zimmer, Andreas

Year: 2012

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2012.07.046

Paper Process optimization of a novel production method for nanosuspensions using design of experiments (DoE).

Salazar, Jaime; Heinzerling, Oliver; Müller, Rainer H et al. · 2011 · International journal of pharmaceutics · DOI

Full title: Process optimization of a novel production method for nanosuspensions using design of experiments (DoE).

Authors: Salazar, Jaime; Heinzerling, Oliver; Müller, Rainer H; Möschwitzer, Jan P

Year: 2011

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2011.09.003

Paper An investigation into the usefulness of different empirical modeling techniques for better control of spray-on fluidized bed melt granulation.

Aleksić, Ivana; Đuriš, Jelena; Ibrić, Svetlana et al. · 2015 · International journal of pharmaceutics · DOI

Full title: An investigation into the usefulness of different empirical modeling techniques for better control of spray-on fluidized bed melt granulation.

Authors: Aleksić, Ivana; Đuriš, Jelena; Ibrić, Svetlana; Parojčić, Jelena

Year: 2015

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2015.11.001

Paper Modelling the response surface to predict the hydrodynamic diameters of theranostic magnetic siRNA nanovectors.

David, Stephanie; Marchais, Hervé; Bedin, Didier et al. · 2015 · International journal of pharmaceutics · DOI

Full title: Modelling the response surface to predict the hydrodynamic diameters of theranostic magnetic siRNA nanovectors.

Authors: David, Stephanie; Marchais, Hervé; Bedin, Didier; Chourpa, Igor

Year: 2015

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2014.11.061

Paper Solid Lipid Nanoparticle assemblies (SLNas) for an anti-TB inhalation treatment-A Design of Experiments approach to investigate the influence of pre-freezing conditions on the powder respirability.

Maretti, Eleonora; Rustichelli, Cecilia; Romagnoli, Marcello et al. · 2016 · International journal of pharmaceutics · DOI

Full title: Solid Lipid Nanoparticle assemblies (SLNas) for an anti-TB inhalation treatment-A Design of Experiments approach to investigate the influence of pre-freezing conditions on the powder respirability.

Authors: Maretti, Eleonora; Rustichelli, Cecilia; Romagnoli, Marcello; Balducci, Anna Giulia; Buttini, Francesca; Sacchetti, Francesca; Leo, Eliana; Iannuccelli, Valentina

Year: 2016

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2016.07.062

Paper Quality by Design approach for studying the impact of formulation and process variables on product quality of oral disintegrating films.

Mazumder, Sonal; Pavurala, Naresh; Manda, Prashanth et al. · 2017 · International journal of pharmaceutics · DOI

Full title: Quality by Design approach for studying the impact of formulation and process variables on product quality of oral disintegrating films.

Authors: Mazumder, Sonal; Pavurala, Naresh; Manda, Prashanth; Xu, Xiaoming; Cruz, Celia N; Krishnaiah, Yellela S R

Year: 2017

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2017.05.048

Paper The application of machine learning algorithms in understanding the effect of core/shell technique on improving powder compactability.

Lou, Hao; Chung, John I; Kiang, Y-H et al. · 2019 · International journal of pharmaceutics · DOI

Full title: The application of machine learning algorithms in understanding the effect of core/shell technique on improving powder compactability.

Authors: Lou, Hao; Chung, John I; Kiang, Y-H; Xiao, Ling-Yun; Hageman, Michael J

Year: 2019

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2018.11.039

Paper Optimization of ciprofloxacin complex loaded PLGA nanoparticles for pulmonary treatment of cystic fibrosis infections: Design of experiments approach.

Günday Türeli, Nazende; Türeli, Akif Emre; Schneider, Marc · 2016 · International journal of pharmaceutics · DOI

Full title: Optimization of ciprofloxacin complex loaded PLGA nanoparticles for pulmonary treatment of cystic fibrosis infections: Design of experiments approach.

Authors: Günday Türeli, Nazende; Türeli, Akif Emre; Schneider, Marc

Year: 2016

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2016.10.025

Paper Carvacrol/clay hybrids loaded into in situ gelling films.

Tenci, M; Rossi, S; Aguzzi, C et al. · 2017 · International journal of pharmaceutics · DOI

Full title: Carvacrol/clay hybrids loaded into in situ gelling films.

Authors: Tenci, M; Rossi, S; Aguzzi, C; Carazo, E; Sandri, G; Bonferoni, M C; Grisoli, P; Viseras, C; Caramella, C M; Ferrari, F

Year: 2017

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2017.06.024

Paper Use of a temperature ramp approach (TRA) to design an optimum and robust freeze-drying process for pharmaceutical formulations.

Assegehegn, Getachew; Brito-de la Fuente, Edmundo; Franco, José M et al. · 2020 · International journal of pharmaceutics · DOI

Full title: Use of a temperature ramp approach (TRA) to design an optimum and robust freeze-drying process for pharmaceutical formulations.

Authors: Assegehegn, Getachew; Brito-de la Fuente, Edmundo; Franco, José M; Gallegos, Críspulo

Year: 2020

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2020.119116

Paper Effects of ionic interactions on protein stability prediction using solid-state hydrogen deuterium exchange with mass spectrometry (ssHDX-MS).

AbouGhaly, Mohamed H H; Du, Jiali; Patel, Sajal M et al. · 2019 · International journal of pharmaceutics · DOI

Full title: Effects of ionic interactions on protein stability prediction using solid-state hydrogen deuterium exchange with mass spectrometry (ssHDX-MS).

Authors: AbouGhaly, Mohamed H H; Du, Jiali; Patel, Sajal M; Topp, Elizabeth M

Year: 2019

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2019.118512

Paper Process optimization of twin-screw melt granulation of fenofibrate using design of experiment (DoE).

Mamidi, Hemanth K; Palekar, Siddhant; Nukala, Pavan Kumar et al. · 2021 · International journal of pharmaceutics · DOI

Full title: Process optimization of twin-screw melt granulation of fenofibrate using design of experiment (DoE).

Authors: Mamidi, Hemanth K; Palekar, Siddhant; Nukala, Pavan Kumar; Mishra, Saurabh M; Patki, Manali; Fu, Yige; Supner, Piyush; Chauhan, Gautam; Patel, Ketan

Year: 2021

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2020.120101

Paper Rheological temperature sweeping in a quality by design approach for formulation development and optimization.

Lauterbach, Andreas; Ekelund, Katarina · 2019 · International journal of pharmaceutics · DOI

Full title: Rheological temperature sweeping in a quality by design approach for formulation development and optimization.

Authors: Lauterbach, Andreas; Ekelund, Katarina

Year: 2019

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2019.118533

Paper Stabilization of HSV-2 viral vaccine candidate by spray drying.

LeClair, Daniel A; Li, Lillian; Rahman, Nausheen et al. · 2019 · International journal of pharmaceutics · DOI

Full title: Stabilization of HSV-2 viral vaccine candidate by spray drying.

Authors: LeClair, Daniel A; Li, Lillian; Rahman, Nausheen; Cranston, Emily D; Xing, Zhou; Thompson, Michael R

Year: 2019

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2019.118615

Paper A Design of Experiment (DoE) approach to optimise spray drying process conditions for the production of trehalose/leucine formulations with application in pulmonary delivery.

Focaroli, S; Mah, P T; Hastedt, J E et al. · 2019 · International journal of pharmaceutics · DOI

Full title: A Design of Experiment (DoE) approach to optimise spray drying process conditions for the production of trehalose/leucine formulations with application in pulmonary delivery.

Authors: Focaroli, S; Mah, P T; Hastedt, J E; Gitlin, I; Oscarson, S; Fahy, J V; Healy, A M

Year: 2019

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2019.03.004

Paper Probabilistic modeling of an injectable aqueous crystalline suspension using influence networks.

Sekulović, Andrea; Petit, Marion; Verrijk, Ruud et al. · 2021 · International journal of pharmaceutics · DOI

Full title: Probabilistic modeling of an injectable aqueous crystalline suspension using influence networks.

Authors: Sekulović, Andrea; Petit, Marion; Verrijk, Ruud; Rades, Thomas; Rantanen, Jukka

Year: 2021

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2021.120283

Paper Pectin microparticles for peptide delivery: Optimization of spray drying processing.

Li, Tingting; Wan, Bo; Jog, Rajan et al. · 2022 · International journal of pharmaceutics · DOI

Full title: Pectin microparticles for peptide delivery: Optimization of spray drying processing.

Authors: Li, Tingting; Wan, Bo; Jog, Rajan; Costa, Antonio; Burgess, Diane J

Year: 2022

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2021.121384

Paper Proof of concept of a predictive model of drug release from long-acting implants obtained by fused-deposition modeling.

Manini, Giuseppe; Benali, Samira; Raquez, Jean-Marie et al. · 2022 · International journal of pharmaceutics · DOI

Full title: Proof of concept of a predictive model of drug release from long-acting implants obtained by fused-deposition modeling.

Authors: Manini, Giuseppe; Benali, Samira; Raquez, Jean-Marie; Goole, Jonathan

Year: 2022

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2022.121663

Paper Encapsulation of a highly hydrophilic drug in polymeric particles: A comparative study of batch and microfluidic processes.

Aboelela, Sarah S; Ibrahim, Mariam; Badruddoza, Abu Zayed M et al. · 2021 · International journal of pharmaceutics · DOI

Full title: Encapsulation of a highly hydrophilic drug in polymeric particles: A comparative study of batch and microfluidic processes.

Authors: Aboelela, Sarah S; Ibrahim, Mariam; Badruddoza, Abu Zayed M; Tran, Valerie; Ferri, James K; Roper, Thomas D

Year: 2021

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2021.120906

Paper Development and optimization of microfluidic assisted manufacturing process to produce PLGA nanoparticles.

Chiesa, Enrica; Bellotti, Marco; Caimi, Alessandro et al. · 2022 · International journal of pharmaceutics · DOI

Full title: Development and optimization of microfluidic assisted manufacturing process to produce PLGA nanoparticles.

Authors: Chiesa, Enrica; Bellotti, Marco; Caimi, Alessandro; Conti, Bice; Dorati, Rossella; Conti, Michele; Genta, Ida; Auricchio, Ferdinando

Year: 2022

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2022.122368

Paper Spray layering of human immunoglobulin G: Optimization of formulation and process parameters.

Jiang, Bowen; Yu, Dongyue; Zhang, Yongrong et al. · 2021 · International journal of pharmaceutics · DOI

Full title: Spray layering of human immunoglobulin G: Optimization of formulation and process parameters.

Authors: Jiang, Bowen; Yu, Dongyue; Zhang, Yongrong; Yu, Hua; Feng, Hanping; Hoag, Stephen W

Year: 2021

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2021.121238

Paper Modeling of a spray drying method to produce ciprofloxacin nanocrystals inside the liposomes utilizing a response surface methodology: Box-Behnken experimental design.

Khatib, Isra; Chow, Michael Y T; Ruan, Juanfang et al. · 2021 · International journal of pharmaceutics · DOI

Full title: Modeling of a spray drying method to produce ciprofloxacin nanocrystals inside the liposomes utilizing a response surface methodology: Box-Behnken experimental design.

Authors: Khatib, Isra; Chow, Michael Y T; Ruan, Juanfang; Cipolla, David; Chan, Hak-Kim

Year: 2021

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2021.120277

Paper Optimising the production of PLGA nanoparticles by combining design of experiment and machine learning.

Seegobin, Nidhi; Abdalla, Youssef; Li, Ge et al. · 2024 · International journal of pharmaceutics · DOI

Full title: Optimising the production of PLGA nanoparticles by combining design of experiment and machine learning.

Authors: Seegobin, Nidhi; Abdalla, Youssef; Li, Ge; Murdan, Sudaxshina; Shorthouse, David; Basit, Abdul W

Year: 2024

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2024.124905

Paper Comparative analysis of tablet dissolution behavior: Batch vs. Continuous direct compression.

Matsunami, Kensaku; Ryckaert, Alexander; Verrecas, Hanne et al. · 2025 · International journal of pharmaceutics · DOI

Full title: Comparative analysis of tablet dissolution behavior: Batch vs. Continuous direct compression.

Authors: Matsunami, Kensaku; Ryckaert, Alexander; Verrecas, Hanne; da Silva, Ana Filipa Tavares; Anderson, Andrew; Wikström, Håkan; Dumarey, Melanie; Mann, James; De Beer, Thomas; Vanhoorne, Valérie; Kumar, Ashish

Year: 2025

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2025.125498

Paper Critical process parameters of gelatin microparticle fabrication with a water-in-oil emulsion method.

Demir, Burak; Hacker, Michael C · 2025 · International journal of pharmaceutics · DOI

Full title: Critical process parameters of gelatin microparticle fabrication with a water-in-oil emulsion method.

Authors: Demir, Burak; Hacker, Michael C

Year: 2025

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2025.126302

Paper Quality by design for Niosome-Based nanocarriers to improve transdermal drug delivery from lab to industry.

Kaur, Prabhjot; Muskan; Kriplani, Priyanka · 2024 · International journal of pharmaceutics · DOI

Full title: Quality by design for Niosome-Based nanocarriers to improve transdermal drug delivery from lab to industry.

Authors: Kaur, Prabhjot; Muskan; Kriplani, Priyanka

Year: 2024

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2024.124747

Paper Scalable microfluidic method for tunable liposomal production by a design of experiment approach.

Buttitta, Giorgio; Bonacorsi, Simone; Barbarito, Chiara et al. · 2024 · International journal of pharmaceutics · DOI

Full title: Scalable microfluidic method for tunable liposomal production by a design of experiment approach.

Authors: Buttitta, Giorgio; Bonacorsi, Simone; Barbarito, Chiara; Moliterno, Mauro; Pompei, Simona; Saito, Gabriele; Oddone, Irene; Verdone, Giuliana; Secci, Daniela; Raimondi, Sergio

Year: 2024

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2024.124460

Paper Automated process development with pure API filling using vacuum drum.

Gallego, Isabel; Brinz, Thomas; Sommerfeld, Martin · 2025 · International journal of pharmaceutics · DOI

Full title: Automated process development with pure API filling using vacuum drum.

Authors: Gallego, Isabel; Brinz, Thomas; Sommerfeld, Martin

Year: 2025

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2025.125665

Paper A multi-step machine learning approach for accelerating QbD-based process development of protein spray drying.

Fiedler, Daniela; Fink, Elisabeth; Aigner, Isabella et al. · 2023 · International journal of pharmaceutics · DOI

Full title: A multi-step machine learning approach for accelerating QbD-based process development of protein spray drying.

Authors: Fiedler, Daniela; Fink, Elisabeth; Aigner, Isabella; Leitinger, Gerd; Keller, Walter; Roblegg, Eva; Khinast, Johannes G

Year: 2023

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2023.123133

Paper A quality-by-design strategic approach for the development of bedaquiline-pretomanid nanoparticles as inhalable dry powders for TB treatment.

Patil, Suyash M; Diorio, Alec M; Kommarajula, Parasharamulu et al. · 2024 · International journal of pharmaceutics · DOI

Full title: A quality-by-design strategic approach for the development of bedaquiline-pretomanid nanoparticles as inhalable dry powders for TB treatment.

Authors: Patil, Suyash M; Diorio, Alec M; Kommarajula, Parasharamulu; Kunda, Nitesh K

Year: 2024

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2024.123920

Paper Quality-by-digital-design for the in-process integration of Raman spectroscopy as a PAT tool in continuous manufacturing of pharmaceutical liquids and semi-solids.

Digkas, Tryfon; Charmchi, Isar; De Beer, Thomas et al. · 2025 · International journal of pharmaceutics · DOI

Full title: Quality-by-digital-design for the in-process integration of Raman spectroscopy as a PAT tool in continuous manufacturing of pharmaceutical liquids and semi-solids.

Authors: Digkas, Tryfon; Charmchi, Isar; De Beer, Thomas; Kumar, Ashish

Year: 2025

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2025.126349

Paper Systematic formulation optimisation to enhance buffer exchange recovery and storage stability for adeno-associated virus (AAV2) vectors.

Carrillo Sanchez, Braulio; Fernández-García, Raquel; Gerontas, Spyridon et al. · 2025 · International journal of pharmaceutics · DOI

Full title: Systematic formulation optimisation to enhance buffer exchange recovery and storage stability for adeno-associated virus (AAV2) vectors.

Authors: Carrillo Sanchez, Braulio; Fernández-García, Raquel; Gerontas, Spyridon; Hales, John E; Aylott, Jonathan W; Dalby, Paul A

Year: 2025

Venue: International journal of pharmaceutics

DOI: https://doi.org/10.1016/j.ijpharm.2025.126312

Paper Integration of Bayesian optimization and solution thermodynamics to optimize media design for mammalian biomanufacturing.

Ndahiro, Nelson; Ma, Edward; Bertalan, Tom et al. · 2025 · iScience · DOI

Full title: Integration of Bayesian optimization and solution thermodynamics to optimize media design for mammalian biomanufacturing.

Authors: Ndahiro, Nelson; Ma, Edward; Bertalan, Tom; Donohue, Marc; Kevrekidis, Yannis; Betenbaugh, Michael

Year: 2025

Venue: iScience

DOI: https://doi.org/10.1016/j.isci.2025.112944

Paper Prediction and optimization of the laccase-mediated synthesis of the antimicrobial compound iodine (I2).

Schubert, M; Fey, A; Ihssen, J et al. · 2015 · Journal of biotechnology · DOI

Full title: Prediction and optimization of the laccase-mediated synthesis of the antimicrobial compound iodine (I2).

Authors: Schubert, M; Fey, A; Ihssen, J; Civardi, C; Schwarze, F W M R; Mourad, S

Year: 2015

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2014.11.029

Paper Synthetic polymers are more effective than natural flocculants for the clarification of tobacco leaf extracts.

Buyel, Johannes F; Fischer, Rainer · 2015 · Journal of biotechnology · DOI

Full title: Synthetic polymers are more effective than natural flocculants for the clarification of tobacco leaf extracts.

Authors: Buyel, Johannes F; Fischer, Rainer

Year: 2015

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2014.12.018

Paper Generation of HIV-1 Gag VLPs by transient transfection of HEK 293 suspension cell cultures using an optimized animal-derived component free medium.

Cervera, Laura; Gutiérrez-Granados, Sonia; Martínez, Marta et al. · 2013 · Journal of biotechnology · DOI

Full title: Generation of HIV-1 Gag VLPs by transient transfection of HEK 293 suspension cell cultures using an optimized animal-derived component free medium.

Authors: Cervera, Laura; Gutiérrez-Granados, Sonia; Martínez, Marta; Blanco, Julià; Gòdia, Francesc; Segura, María Mercedes

Year: 2013

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2013.05.001

Paper Controlling neural territory patterning from pluripotency using a systems developmental biology approach.

Sears, Katie E; Gullapalli, Keerthi; Trivedi, Divya et al. · 2022 · iScience · DOI

Full title: Controlling neural territory patterning from pluripotency using a systems developmental biology approach.

Authors: Sears, Katie E; Gullapalli, Keerthi; Trivedi, Divya; Mihas, Alexander; Bukys, Michael A; Jensen, Jan

Year: 2022

Venue: iScience

DOI: https://doi.org/10.1016/j.isci.2022.104133

Paper Process optimization and kinetic modelling of cyclic (1→3, 1→6)-β-glucans production from Bradyrhizobium japonicum MTCC120.

Nair, Anju V; Gummadi, Sathyanarayana N; Doble, Mukesh · 2016 · Journal of biotechnology · DOI

Full title: Process optimization and kinetic modelling of cyclic (1→3, 1→6)-β-glucans production from Bradyrhizobium japonicum MTCC120.

Authors: Nair, Anju V; Gummadi, Sathyanarayana N; Doble, Mukesh

Year: 2016

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2016.03.055

Paper Optimisation of enzyme cascades for chiral amino alcohol synthesis in aid of host cell integration using a statistical experimental design approach.

Villegas-Torres, Maria F; Ward, John M; Baganz, Frank · 2018 · Journal of biotechnology · DOI

Full title: Optimisation of enzyme cascades for chiral amino alcohol synthesis in aid of host cell integration using a statistical experimental design approach.

Authors: Villegas-Torres, Maria F; Ward, John M; Baganz, Frank

Year: 2018

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2018.07.014

Paper Sequential active learning for medium optimization in mAb production.

Hashizume, Takamasa; Baba, Koki; Matsuo, Naoya et al. · 2026 · Journal of bioscience and bioengineering · DOI

Full title: Sequential active learning for medium optimization in mAb production.

Authors: Hashizume, Takamasa; Baba, Koki; Matsuo, Naoya; Ying, Bei-Wen

Year: 2026

Venue: Journal of bioscience and bioengineering

DOI: https://doi.org/10.1016/j.jbiosc.2025.12.002

Paper Designing new monoclonal antibody purification processes using mixed-mode chromatography sorbents.

Toueille, Magali; Uzel, Audrey; Depoisier, Jean-François et al. · 2011 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · DOI

Full title: Designing new monoclonal antibody purification processes using mixed-mode chromatography sorbents.

Authors: Toueille, Magali; Uzel, Audrey; Depoisier, Jean-François; Gantier, René

Year: 2011

Venue: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

DOI: https://doi.org/10.1016/j.jchromb.2011.02.047

Paper Systematic screening for the biocatalytic hydration of fatty acids from different oily substrates by Elizabethkingia meningoseptica oleate hydratase through a Design-of-experiments approach.

Biundo, Antonino; Lima, Serena; Ciaccia, Marianna et al. · 2024 · Journal of biotechnology · DOI

Full title: Systematic screening for the biocatalytic hydration of fatty acids from different oily substrates by Elizabethkingia meningoseptica oleate hydratase through a Design-of-experiments approach.

Authors: Biundo, Antonino; Lima, Serena; Ciaccia, Marianna; Ciliberti, Cosetta; Serpico, Annabel; Agrimi, Gennaro; Scargiali, Francesca; Pisano, Isabella

Year: 2024

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2024.06.016

Paper Design of experiments-based RP - HPLC bioanalytical method development for estimation of Rufinamide in rat plasma and brain and its application in pharmacokinetic study.

Dalvi, Avantika V; Uppuluri, Chandra Teja; Bommireddy, Ekta Prasanthi et al. · 2018 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · DOI

Full title: Design of experiments-based RP - HPLC bioanalytical method development for estimation of Rufinamide in rat plasma and brain and its application in pharmacokinetic study.

Authors: Dalvi, Avantika V; Uppuluri, Chandra Teja; Bommireddy, Ekta Prasanthi; Ravi, Punna Rao

Year: 2018

Venue: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

DOI: https://doi.org/10.1016/j.jchromb.2018.10.014

Paper Use of response surface methodology in a fed-batch process for optimization of tricarboxylic acid cycle intermediates to achieve high levels of canthaxanthin from Dietzia natronolimnaea HS-1.

Nasri Nasrabadi, Mohammad Reza; Razavi, Seyed Hadi · 2010 · Journal of bioscience and bioengineering · DOI

Full title: Use of response surface methodology in a fed-batch process for optimization of tricarboxylic acid cycle intermediates to achieve high levels of canthaxanthin from Dietzia natronolimnaea HS-1.

Authors: Nasri Nasrabadi, Mohammad Reza; Razavi, Seyed Hadi

Year: 2010

Venue: Journal of bioscience and bioengineering

DOI: https://doi.org/10.1016/j.jbiosc.2009.10.013

Paper Coupling metabolomics analysis and DOE optimization strategy towards enhanced IBDV production by chicken embryo fibroblast DF-1 cells.

Lin, Jia; Yi, Xiaoping; Zhuang, Yingping · 2020 · Journal of biotechnology · DOI

Full title: Coupling metabolomics analysis and DOE optimization strategy towards enhanced IBDV production by chicken embryo fibroblast DF-1 cells.

Authors: Lin, Jia; Yi, Xiaoping; Zhuang, Yingping

Year: 2020

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2019.10.018

Paper Development of an intermediate chromatography step in an insulin purification process. The use of a High Throughput Process Development approach based on selectivity parameters.

Heldin, Eva; Grönlund, Sara; Shanagar, Jamil et al. · 2014 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · DOI

Full title: Development of an intermediate chromatography step in an insulin purification process. The use of a High Throughput Process Development approach based on selectivity parameters.

Authors: Heldin, Eva; Grönlund, Sara; Shanagar, Jamil; Hallgren, Elisabeth; Eriksson, Kjell; Xavier, Mariza; Tunes, Heloisa; Vilela, Luciano

Year: 2014

Venue: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

DOI: https://doi.org/10.1016/j.jchromb.2014.09.024

Paper Effectively removing the homodimer in bispecific antibodies by weak partitioning mode of anion exchange chromatography.

Liang, Xiaoying; He, Qingquan; Qin, Guohong et al. · 2023 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · DOI

Full title: Effectively removing the homodimer in bispecific antibodies by weak partitioning mode of anion exchange chromatography.

Authors: Liang, Xiaoying; He, Qingquan; Qin, Guohong; Li, Guozhu; Li, Qian; Tan, Huanghong; Wang, Zichen; Fan, Mengni; Xu, Dan

Year: 2023

Venue: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

DOI: https://doi.org/10.1016/j.jchromb.2023.123767

Paper Statistical experimental designs to optimize the transient transfection of HEK 293T cells and determine a transfer criterion from adherent cells to larger-scale cell suspension cultures.

Dekevic, Gregor; Tasto, Lars; Czermak, Peter et al. · 2022 · Journal of biotechnology · DOI

Full title: Statistical experimental designs to optimize the transient transfection of HEK 293T cells and determine a transfer criterion from adherent cells to larger-scale cell suspension cultures.

Authors: Dekevic, Gregor; Tasto, Lars; Czermak, Peter; Salzig, Denise

Year: 2022

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2022.01.004

Paper Accelerated development of a SEC-HPLC procedure for purity analysis of monoclonal antibodies using design of experiments.

Cernosek, Terezie; Jain, Nitin; Dalphin, Matthew et al. · 2024 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · DOI

Full title: Accelerated development of a SEC-HPLC procedure for purity analysis of monoclonal antibodies using design of experiments.

Authors: Cernosek, Terezie; Jain, Nitin; Dalphin, Matthew; Behrens, Sue; Wunderli, Peter

Year: 2024

Venue: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

DOI: https://doi.org/10.1016/j.jchromb.2024.124037

Paper A case study application of AQbD to the re-development and validation of an affinity chromatography analytical procedure for mAb titer quantitation.

Cernosek, Terezie; Dalphin, Matthew; Jain, Nitin et al. · 2024 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · DOI

Full title: A case study application of AQbD to the re-development and validation of an affinity chromatography analytical procedure for mAb titer quantitation.

Authors: Cernosek, Terezie; Dalphin, Matthew; Jain, Nitin; Lor, Jason; Richter, Noah; Mellal, Mourad; Behrens, Sue; Wunderli, Peter

Year: 2024

Venue: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

DOI: https://doi.org/10.1016/j.jchromb.2024.124205

Paper Model assisted comparison of Protein A resins and multi-column chromatography for capture processes.

Baur, Daniel; Angelo, James M; Chollangi, Srinivas et al. · 2018 · Journal of biotechnology · DOI

Full title: Model assisted comparison of Protein A resins and multi-column chromatography for capture processes.

Authors: Baur, Daniel; Angelo, James M; Chollangi, Srinivas; Xu, Xuankuo; Müller-Späth, Thomas; Zhang, Na; Ghose, Sanchayita; Li, Zheng Jian; Morbidelli, Massimo

Year: 2018

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2018.08.014

Paper Broad application and optimization of a single wash-step for integrated endotoxin depletion during protein purification.

Koziel, David; Michaelis, Uwe; Kruse, Tobias · 2018 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · DOI

Full title: Broad application and optimization of a single wash-step for integrated endotoxin depletion during protein purification.

Authors: Koziel, David; Michaelis, Uwe; Kruse, Tobias

Year: 2018

Venue: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

DOI: https://doi.org/10.1016/j.jchromb.2018.05.029

Paper Experimental design in chromatography: a tutorial review.

Hibbert, D Brynn · 2012 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · DOI

Full title: Experimental design in chromatography: a tutorial review.

Authors: Hibbert, D Brynn

Year: 2012

Venue: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

DOI: https://doi.org/10.1016/j.jchromb.2012.01.020

Paper Efficient host cell protein clearance: A study of membrane adsorbers and resins in biopharmaceutical processes.

Šprager, Ernest; Reisinger, Veronika; Sommer, Jonas et al. · 2025 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · DOI

Full title: Efficient host cell protein clearance: A study of membrane adsorbers and resins in biopharmaceutical processes.

Authors: Šprager, Ernest; Reisinger, Veronika; Sommer, Jonas; Lekić, Tinkara; Pucelj, Nina; Kljun, Tina; Lunder, Mojca; Vašl, Jožica; Bratkovič, Tomaž

Year: 2025

Venue: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

DOI: https://doi.org/10.1016/j.jchromb.2025.124796

Paper The use of design of experiments with multiple responses to determine optimal formulations for in vivo hepatic mRNA delivery.

Hashiba, Akari; Toyooka, Manaya; Sato, Yusuke et al. · 2020 · Journal of controlled release : official journal of the Controlled Release Society · DOI

Full title: The use of design of experiments with multiple responses to determine optimal formulations for in vivo hepatic mRNA delivery.

Authors: Hashiba, Akari; Toyooka, Manaya; Sato, Yusuke; Maeki, Masatoshi; Tokeshi, Manabu; Harashima, Hideyoshi

Year: 2020

Venue: Journal of controlled release : official journal of the Controlled Release Society

DOI: https://doi.org/10.1016/j.jconrel.2020.08.031

Paper Biphasic cultivation strategy to avoid Epo-Fc aggregation and optimize protein expression.

Kaisermayer, Christian; Reinhart, David; Gili, Andreas et al. · 2016 · Journal of biotechnology · DOI

Full title: Biphasic cultivation strategy to avoid Epo-Fc aggregation and optimize protein expression.

Authors: Kaisermayer, Christian; Reinhart, David; Gili, Andreas; Chang, Martina; Aberg, Per-Mikael; Castan, Andreas; Kunert, Renate

Year: 2016

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2016.03.054

Paper Optimization and validation of analytical affinity chromatography for the in-process monitoring and quantification of peptides containing a C-tag.

Lappöhn, Carolin A; Maerz, Lea; Stei, Robin et al. · 2023 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · DOI

Full title: Optimization and validation of analytical affinity chromatography for the in-process monitoring and quantification of peptides containing a C-tag.

Authors: Lappöhn, Carolin A; Maerz, Lea; Stei, Robin; Weber, Linus G; Wolff, Michael W

Year: 2023

Venue: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

DOI: https://doi.org/10.1016/j.jchromb.2023.123899

Paper Nanoparticles laden In situ gel for sustained drug release after topical ocular administration

U. UpadhyayShivam; K. ChavanSiddhi; U. GajjarDevarshi et al. · 2020 · DOI

Full title: Nanoparticles laden In situ gel for sustained drug release after topical ocular administration

Authors: U. UpadhyayShivam; K. ChavanSiddhi; U. GajjarDevarshi; M. UpadhyayUmeshkumar; K. PatelJayvadan

Year: 2020

DOI: https://doi.org/10.1016/j.jddst.2020.101736

Paper Design of experiments as a decision tool for cell therapy manufacturing.

Lee, Esmond; Shah, Devin; Porteus, Matthew et al. · 2022 · Cytotherapy · DOI

Full title: Design of experiments as a decision tool for cell therapy manufacturing.

Authors: Lee, Esmond; Shah, Devin; Porteus, Matthew; Wright, J Fraser; Bacchetta, Rosa

Year: 2022

Venue: Cytotherapy

DOI: https://doi.org/10.1016/j.jcyt.2022.01.009

Paper Combined Homogeneous Surface Diffusion Model - Design of experiments approach to optimize dye adsorption considering both equilibrium and kinetic aspects.

Muthukkumaran, A; Aravamudan, K · 2017 · Journal of environmental management · DOI

Full title: Combined Homogeneous Surface Diffusion Model - Design of experiments approach to optimize dye adsorption considering both equilibrium and kinetic aspects.

Authors: Muthukkumaran, A; Aravamudan, K

Year: 2017

Venue: Journal of environmental management

DOI: https://doi.org/10.1016/j.jenvman.2017.09.010

Paper Optimization of co-culture inoculated microbial fuel cell performance using response surface methodology.

Islam, M Amirul; Ong, Huei Ruey; Ethiraj, Baranitharan et al. · 2018 · Journal of environmental management · DOI

Full title: Optimization of co-culture inoculated microbial fuel cell performance using response surface methodology.

Authors: Islam, M Amirul; Ong, Huei Ruey; Ethiraj, Baranitharan; Cheng, Chin Kui; Rahman Khan, Md Maksudur

Year: 2018

Venue: Journal of environmental management

DOI: https://doi.org/10.1016/j.jenvman.2018.08.002

Paper Optimizing ELISAs for precision and robustness using laboratory automation and statistical design of experiments.

Joelsson, Daniel; Moravec, Phil; Troutman, Matthew et al. · 2008 · Journal of immunological methods · DOI

Full title: Optimizing ELISAs for precision and robustness using laboratory automation and statistical design of experiments.

Authors: Joelsson, Daniel; Moravec, Phil; Troutman, Matthew; Pigeon, Joseph; DePhillips, Pete

Year: 2008

Venue: Journal of immunological methods

DOI: https://doi.org/10.1016/j.jim.2008.05.012

Paper Biosorption equilibria of binary Cd(II) and Ni(II) systems onto Saccharomyces cerevisiae and Ralstonia eutropha cells: application of response surface methodology.

Fereidouni, Mohammad; Daneshi, Ali; Younesi, Habibollah · 2009 · Journal of hazardous materials · DOI

Full title: Biosorption equilibria of binary Cd(II) and Ni(II) systems onto Saccharomyces cerevisiae and Ralstonia eutropha cells: application of response surface methodology.

Authors: Fereidouni, Mohammad; Daneshi, Ali; Younesi, Habibollah

Year: 2009

Venue: Journal of hazardous materials

DOI: https://doi.org/10.1016/j.jhazmat.2009.03.041

Paper Optimization of laccase production from Aspergillus flavus by design of experiment technique: Partial purification and characterization

Kumar, Rajesh; Kaur, Jaswinder; Jain, Saurabh et al. · 2016 · Journal of Genetic Engineering and Biotechnology · DOI

Full title: Optimization of laccase production from Aspergillus flavus by design of experiment technique: Partial purification and characterization

Authors: Kumar, Rajesh; Kaur, Jaswinder; Jain, Saurabh; Kumar, Ashwani

Year: 2016

Venue: Journal of Genetic Engineering and Biotechnology

DOI: https://doi.org/10.1016/j.jgeb.2016.05.006

Paper Implementation of design of experiments (DOE) in the development and validation of a cell-based bioassay for the detection of anti-drug neutralizing antibodies in human serum.

Chen, Xinyi C; Zhou, Lei; Gupta, Shalini et al. · 2012 · Journal of immunological methods · DOI

Full title: Implementation of design of experiments (DOE) in the development and validation of a cell-based bioassay for the detection of anti-drug neutralizing antibodies in human serum.

Authors: Chen, Xinyi C; Zhou, Lei; Gupta, Shalini; Civoli, Francesca

Year: 2012

Venue: Journal of immunological methods

DOI: https://doi.org/10.1016/j.jim.2011.11.004

Paper Aggregation factor analysis for protein formulation by a systematic approach using FTIR, SEC and design of experiments techniques.

Feng, Yan Wen; Ooishi, Ayako; Honda, Shinya · 2012 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Aggregation factor analysis for protein formulation by a systematic approach using FTIR, SEC and design of experiments techniques.

Authors: Feng, Yan Wen; Ooishi, Ayako; Honda, Shinya

Year: 2012

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2011.08.035

Paper Development of FAcE (Formulated Alhydrogel competitive ELISA) method for direct quantification of OAg present in Shigella sonnei GMMA-based vaccine and its optimization using Design of Experiments approach.

Necchi, Francesca; Carducci, Martina; Pisoni, Ivan et al. · 2019 · Journal of immunological methods · DOI

Full title: Development of FAcE (Formulated Alhydrogel competitive ELISA) method for direct quantification of OAg present in Shigella sonnei GMMA-based vaccine and its optimization using Design of Experiments approach.

Authors: Necchi, Francesca; Carducci, Martina; Pisoni, Ivan; Rossi, Omar; Saul, Allan; Rondini, Simona

Year: 2019

Venue: Journal of immunological methods

DOI: https://doi.org/10.1016/j.jim.2019.04.012

Paper Implementation of a design space approach for enantiomeric separations in polar organic solvent chromatography.

Nistor, Iolanda; Lebrun, Pierre; Ceccato, Attilio et al. · 2013 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Implementation of a design space approach for enantiomeric separations in polar organic solvent chromatography.

Authors: Nistor, Iolanda; Lebrun, Pierre; Ceccato, Attilio; Lecomte, Frédéric; Slama, Ines; Oprean, Radu; Badarau, Eduard; Dufour, Fabien; Dossou, Katina Sourou Sylvestre; Fillet, Marianne; Liégeois, Jean-François; Hubert, Philippe; Rozet, Eric

Year: 2013

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2012.10.015

Paper Application of multi-factorial design of experiments to successfully optimize immunoassays for robust measurements of therapeutic proteins.

Ray, Chad A; Patel, Vimal; Shih, Judy et al. · 2009 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Application of multi-factorial design of experiments to successfully optimize immunoassays for robust measurements of therapeutic proteins.

Authors: Ray, Chad A; Patel, Vimal; Shih, Judy; Macaraeg, Chris; Wu, Yuling; Thway, Theingi; Ma, Mark; Lee, Jean W; Desilva, Binodh

Year: 2009

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2008.11.039

Paper Development and validation of an alpha fetoprotein immunoassay using Gyros technology.

Given, Allison M; Whalen, Pamela M; O'Brien, Peter J et al. · 2012 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Development and validation of an alpha fetoprotein immunoassay using Gyros technology.

Authors: Given, Allison M; Whalen, Pamela M; O'Brien, Peter J; Ray, Chad A

Year: 2012

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2012.02.001

Paper Improved quality-by-design compliant methodology for method development in reversed-phase liquid chromatography.

Debrus, Benjamin; Guillarme, Davy; Rudaz, Serge · 2013 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Improved quality-by-design compliant methodology for method development in reversed-phase liquid chromatography.

Authors: Debrus, Benjamin; Guillarme, Davy; Rudaz, Serge

Year: 2013

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2013.06.013

Paper Renewal of an old European Pharmacopoeia method for Terazosin using modeling with mass spectrometric peak tracking.

Kormány, Róbert; Molnár, Imre; Fekete, Jenő · 2017 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Renewal of an old European Pharmacopoeia method for Terazosin using modeling with mass spectrometric peak tracking.

Authors: Kormány, Róbert; Molnár, Imre; Fekete, Jenő

Year: 2017

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2016.11.050

Paper Quality by Design oriented development of hydrophilic interaction liquid chromatography method for the analysis of amitriptyline and its impurities.

Kasagić-Vujanović, Irena; Jančić-Stojanović, Biljana · 2019 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Quality by Design oriented development of hydrophilic interaction liquid chromatography method for the analysis of amitriptyline and its impurities.

Authors: Kasagić-Vujanović, Irena; Jančić-Stojanović, Biljana

Year: 2019

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2019.05.026

Paper Supercritical fluid chromatography approach for a sustainable manufacture of new stereoisomeric anticancer agent.

Ghinet, Alina; Zehani, Yasmine; Lipka, Emmanuelle · 2017 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Supercritical fluid chromatography approach for a sustainable manufacture of new stereoisomeric anticancer agent.

Authors: Ghinet, Alina; Zehani, Yasmine; Lipka, Emmanuelle

Year: 2017

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2017.08.006

Paper Development of an integrated chromatographic system for ω-transaminase-IMER characterization useful for flow-chemistry applications.

Corti, M; Rinaldi, F; Monti, D et al. · 2019 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Development of an integrated chromatographic system for ω-transaminase-IMER characterization useful for flow-chemistry applications.

Authors: Corti, M; Rinaldi, F; Monti, D; Ferrandi, E E; Marrubini, G; Temporini, C; Tripodo, G; Kupfer, T; Conti, P; Terreni, M; Massolini, G; Calleri, E

Year: 2019

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2019.03.020

Paper Increased sensitivity of SPR assays in plasma through efficient parallel assay optimization.

Moberg, Anna; Lager, Anna; Hämäläinen, Markku D et al. · 2013 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Increased sensitivity of SPR assays in plasma through efficient parallel assay optimization.

Authors: Moberg, Anna; Lager, Anna; Hämäläinen, Markku D; Jarhede, Tanja

Year: 2013

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2013.02.018

Paper Optimization of a liquid chromatography method for the analysis of related substances in daclatasvir tablets using design of experiments integrated with the steepest ascent method and Monte Carlo simulation.

Tol, Trupti; Tawde, Harshad; Gorad, Savita et al. · 2020 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Optimization of a liquid chromatography method for the analysis of related substances in daclatasvir tablets using design of experiments integrated with the steepest ascent method and Monte Carlo simulation.

Authors: Tol, Trupti; Tawde, Harshad; Gorad, Savita; Jagdale, Avinash; Kulkarni, Amol; Kasbale, Avinash; Desai, Anita; Samanta, Gautam

Year: 2020

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2019.112943

Paper Implementation of design of experiments for optimization of forced degradation conditions and development of a stability-indicating method for furosemide.

Kurmi, Moolchand; Kumar, Sanjay; Singh, Bhupinder et al. · 2014 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Implementation of design of experiments for optimization of forced degradation conditions and development of a stability-indicating method for furosemide.

Authors: Kurmi, Moolchand; Kumar, Sanjay; Singh, Bhupinder; Singh, Saranjit

Year: 2014

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2014.03.035

Paper A Quality by Design (QbD) approach to the development of a gradient high-performance liquid chromatography for the simultaneous assay of curcuminoids and doxorubicin from long-circulating liposomes.

Sylvester, Bianca; Tefas, Lucia; Vlase, Laurian et al. · 2018 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: A Quality by Design (QbD) approach to the development of a gradient high-performance liquid chromatography for the simultaneous assay of curcuminoids and doxorubicin from long-circulating liposomes.

Authors: Sylvester, Bianca; Tefas, Lucia; Vlase, Laurian; Tomuţă, Ioan; Porfire, Alina

Year: 2018

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2018.06.018

Paper When it is too much: Identifying butamben excess on the surface of pharmaceutical preformulation samples by Raman mapping.

Mitsutake, Hery; Rodrigues da Silva, Gustavo H; de Paula, Eneida et al. · 2023 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: When it is too much: Identifying butamben excess on the surface of pharmaceutical preformulation samples by Raman mapping.

Authors: Mitsutake, Hery; Rodrigues da Silva, Gustavo H; de Paula, Eneida; Breitkreitz, Márcia C

Year: 2023

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2023.115644

Paper Design of experiments as a tool for LC-MS/MS method development for the trace analysis of the potentially genotoxic 4-dimethylaminopyridine impurity in glucocorticoids.

Székely, Gy; Henriques, B; Gil, M et al. · 2012 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Design of experiments as a tool for LC-MS/MS method development for the trace analysis of the potentially genotoxic 4-dimethylaminopyridine impurity in glucocorticoids.

Authors: Székely, Gy; Henriques, B; Gil, M; Ramos, A; Alvarez, C

Year: 2012

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2012.07.006

Paper Analytical method development supported by DoE-DS approach for enantioseparation of (S,S)- and (R,R)-moxifloxacin.

Rašević, Marija; Malenović, Anđelija; Protić, Ana et al. · 2023 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Analytical method development supported by DoE-DS approach for enantioseparation of (S,S)- and (R,R)-moxifloxacin.

Authors: Rašević, Marija; Malenović, Anđelija; Protić, Ana; Zečević, Mira

Year: 2023

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2023.115645

Paper Analytical quality-by-design approach for sample treatment of BSA-containing solutions.

Taevernier, Lien; Wynendaele, Evelien; D Hondt, Matthias et al. · 2015 · Journal of pharmaceutical analysis · DOI

Full title: Analytical quality-by-design approach for sample treatment of BSA-containing solutions.

Authors: Taevernier, Lien; Wynendaele, Evelien; D Hondt, Matthias; De Spiegeleer, Bart

Year: 2015

Venue: Journal of pharmaceutical analysis

DOI: https://doi.org/10.1016/j.jpha.2014.06.001

Paper Enhancing analytical development in the pharmaceutical industry: A DoE-QSRR model for virtual Method Operable Design Region assessment.

Passarin, Paula Beatriz Silva; Lourenço, Felipe Rebello · 2024 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Enhancing analytical development in the pharmaceutical industry: A DoE-QSRR model for virtual Method Operable Design Region assessment.

Authors: Passarin, Paula Beatriz Silva; Lourenço, Felipe Rebello

Year: 2024

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2023.115907

Paper Validated mass spectrometric assay for the quantification of substance P and human hemokinin-1 in plasma samples: A design of experiments concept for comprehensive method development.

Feickert, Martin; Burckhardt, Bjoern B · 2020 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Validated mass spectrometric assay for the quantification of substance P and human hemokinin-1 in plasma samples: A design of experiments concept for comprehensive method development.

Authors: Feickert, Martin; Burckhardt, Bjoern B

Year: 2020

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2020.113542

Paper Predicting liquid chromatography-electrospray ionization/mass spectrometry signal from the structure of model compounds and experimental factors; case study of aripiprazole and its impurities.

Krmar, Jovana; Stojadinović, Ljiljana Tolić; Đurkić, Tatjana et al. · 2023 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Predicting liquid chromatography-electrospray ionization/mass spectrometry signal from the structure of model compounds and experimental factors; case study of aripiprazole and its impurities.

Authors: Krmar, Jovana; Stojadinović, Ljiljana Tolić; Đurkić, Tatjana; Protić, Ana; Otašević, Biljana

Year: 2023

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2023.115422

Paper Application of experimental design in HPLC method optimisation for the simultaneous determination of multiple bioactive cannabinoids.

Durante, Caterina; Anceschi, Lisa; Brighenti, Virginia et al. · 2022 · Journal of pharmaceutical and biomedical analysis · DOI

Full title: Application of experimental design in HPLC method optimisation for the simultaneous determination of multiple bioactive cannabinoids.

Authors: Durante, Caterina; Anceschi, Lisa; Brighenti, Virginia; Caroli, Clarissa; Afezolli, Cindy; Marchetti, Andrea; Cocchi, Marina; Salamone, Stefano; Pollastro, Federica; Pellati, Federica

Year: 2022

Venue: Journal of pharmaceutical and biomedical analysis

DOI: https://doi.org/10.1016/j.jpba.2022.115037

Paper Membrane-based steric exclusion chromatography for the purification of a recombinant baculovirus and its application for cell therapy.

Lothert, Keven; Sprick, Gundula; Beyer, Felix et al. · 2020 · Journal of virological methods · DOI

Full title: Membrane-based steric exclusion chromatography for the purification of a recombinant baculovirus and its application for cell therapy.

Authors: Lothert, Keven; Sprick, Gundula; Beyer, Felix; Lauria, Guiliano; Czermak, Peter; Wolff, Michael W

Year: 2020

Venue: Journal of virological methods

DOI: https://doi.org/10.1016/j.jviromet.2019.113756

Paper Tuning the performance of a TphR-based terephthalate biosensor with a design of experiments approach.

Alvarez Gonzalez, Guadalupe; Chacón, Micaela; Butterfield, Thomas et al. · 2024 · Metabolic engineering communications · DOI

Full title: Tuning the performance of a TphR-based terephthalate biosensor with a design of experiments approach.

Authors: Alvarez Gonzalez, Guadalupe; Chacón, Micaela; Butterfield, Thomas; Dixon, Neil

Year: 2024

Venue: Metabolic engineering communications

DOI: https://doi.org/10.1016/j.mec.2024.e00250

Paper Optimization of heterologous production of Bacillus ligniniphilus L1 laccase in Escherichia coli through statistical design of experiments.

Mutanda, Ishmael; Zahoor; Sethupathy, Sivasamy et al. · 2023 · Microbiological research · DOI

Full title: Optimization of heterologous production of Bacillus ligniniphilus L1 laccase in Escherichia coli through statistical design of experiments.

Authors: Mutanda, Ishmael; Zahoor; Sethupathy, Sivasamy; Xu, Qi; Zhu, Bin; Shah, Sayed Waqas Ali; Zhuang, Zhipeng; Zhu, Daochen

Year: 2023

Venue: Microbiological research

DOI: https://doi.org/10.1016/j.micres.2023.127416

Paper Optimization of rabies virus production in neuroblastoma cells using quality by design principles for vaccine and diagnostic applications.

Ugeda, Nayara; Ribeiro, Orlando Garcia; Fernandes, Elaine Raniero et al. · 2026 · Journal of virological methods · DOI

Full title: Optimization of rabies virus production in neuroblastoma cells using quality by design principles for vaccine and diagnostic applications.

Authors: Ugeda, Nayara; Ribeiro, Orlando Garcia; Fernandes, Elaine Raniero; Guedes, Fernanda; Dos Ramos Silva, Sandriana; Katz, Iana Suly Santos

Year: 2026

Venue: Journal of virological methods

DOI: https://doi.org/10.1016/j.jviromet.2025.115289

Paper Establishment of a cell-free multi-enzyme cascade for the synthesis of UDP-GalNAc.

Hoang, Tuan Son; Wormstall, Sara-Theres; Hoang, Nam-Hai et al. · 2025 · New biotechnology · DOI

Full title: Establishment of a cell-free multi-enzyme cascade for the synthesis of UDP-GalNAc.

Authors: Hoang, Tuan Son; Wormstall, Sara-Theres; Hoang, Nam-Hai; Reichl, Udo; Rexer, Thomas F T

Year: 2025

Venue: New biotechnology

DOI: https://doi.org/10.1016/j.nbt.2025.05.003

Paper Maximizing the recovery of the native p28 bacterial peptide with improved activity and maintained solubility and stability in Escherichia coli BL21 (DE3).

Abuei, Haniyeh; Pirouzfar, Mohammad; Mojiri, Anahita et al. · 2022 · Journal of microbiological methods · DOI

Full title: Maximizing the recovery of the native p28 bacterial peptide with improved activity and maintained solubility and stability in Escherichia coli BL21 (DE3).

Authors: Abuei, Haniyeh; Pirouzfar, Mohammad; Mojiri, Anahita; Behzad-Behbahani, Abbas; Kalantari, Tahereh; Bemani, Peyman; Farhadi, Ali

Year: 2022

Venue: Journal of microbiological methods

DOI: https://doi.org/10.1016/j.mimet.2022.106560

Paper Optimisation of DNA electroporation protocols for different plant-associated bacteria.

Kim, Edson Yu Sin; Maltempi de Souza, Emanuel; Müller-Santos, Marcelo · 2024 · Journal of microbiological methods · DOI

Full title: Optimisation of DNA electroporation protocols for different plant-associated bacteria.

Authors: Kim, Edson Yu Sin; Maltempi de Souza, Emanuel; Müller-Santos, Marcelo

Year: 2024

Venue: Journal of microbiological methods

DOI: https://doi.org/10.1016/j.mimet.2024.106912

Paper Micrometric DNA/PEI polyplexes correlate with higher transient gene expression yields in HEK 293 cells.

González-Domínguez, Irene; Puente-Massaguer, Eduard; Lavado-García, Jesús et al. · 2022 · New biotechnology · DOI

Full title: Micrometric DNA/PEI polyplexes correlate with higher transient gene expression yields in HEK 293 cells.

Authors: González-Domínguez, Irene; Puente-Massaguer, Eduard; Lavado-García, Jesús; Cervera, Laura; Gòdia, Francesc

Year: 2022

Venue: New biotechnology

DOI: https://doi.org/10.1016/j.nbt.2022.02.002

Paper Optimization of sustained release aceclofenac microspheres using response surface methodology.

Deshmukh, Rameshwar K; Naik, Jitendra B · 2015 · Materials science & engineering. C, Materials for biological applications · DOI

Full title: Optimization of sustained release aceclofenac microspheres using response surface methodology.

Authors: Deshmukh, Rameshwar K; Naik, Jitendra B

Year: 2015

Venue: Materials science & engineering. C, Materials for biological applications

DOI: https://doi.org/10.1016/j.msec.2014.12.008

Paper Analytical approach for identification and mechanistic insights into mRNA-lipid adduct formation.

Peronin, Sebastien; Malburet, Camille; Daher-Hassan, Chamsan et al. · 2025 · Molecular therapy. Nucleic acids · DOI

Full title: Analytical approach for identification and mechanistic insights into mRNA-lipid adduct formation.

Authors: Peronin, Sebastien; Malburet, Camille; Daher-Hassan, Chamsan; Picard, Christelle; Willemin, Thibaut; Costamagna, Federica; Even, Luc; Eynard, Thierry; Bensaid, Fethi; Fertier-Prizzon, Stéphanie; Francois-Heude, Marc

Year: 2025

Venue: Molecular therapy. Nucleic acids

DOI: https://doi.org/10.1016/j.omtn.2025.102684

Paper PCL foamed scaffolds loaded with 5-fluorouracil anti-cancer drug prepared by an eco-friendly route.

Salerno, Aurelio; Domingo, Concepción; Saurina, Javier · 2017 · Materials science & engineering. C, Materials for biological applications · DOI

Full title: PCL foamed scaffolds loaded with 5-fluorouracil anti-cancer drug prepared by an eco-friendly route.

Authors: Salerno, Aurelio; Domingo, Concepción; Saurina, Javier

Year: 2017

Venue: Materials science & engineering. C, Materials for biological applications

DOI: https://doi.org/10.1016/j.msec.2017.03.011

Paper Optimisation of a simple method to transiently transfect a CHO cell line in high-throughput and at large scale.

Abbott, W Mark; Middleton, Brian; Kartberg, Fredrik et al. · 2015 · Protein expression and purification · DOI

Full title: Optimisation of a simple method to transiently transfect a CHO cell line in high-throughput and at large scale.

Authors: Abbott, W Mark; Middleton, Brian; Kartberg, Fredrik; Claesson, Josefine; Roth, Robert; Fisher, David

Year: 2015

Venue: Protein expression and purification

DOI: https://doi.org/10.1016/j.pep.2015.08.016

Paper Design of Experiment in CHO and HEK transient transfection condition optimization.

Bollin, Frederic; Dechavanne, Vincent; Chevalet, Laurent · 2011 · Protein expression and purification · DOI

Full title: Design of Experiment in CHO and HEK transient transfection condition optimization.

Authors: Bollin, Frederic; Dechavanne, Vincent; Chevalet, Laurent

Year: 2011

Venue: Protein expression and purification

DOI: https://doi.org/10.1016/j.pep.2011.02.008

Paper Unlocking DOE potential by selecting the most appropriate design for rAAV optimization.

Tzimou, Konstantina; Catalán-Tatjer, David; Nielsen, Lars K et al. · 2024 · Molecular therapy. Methods & clinical development · DOI

Full title: Unlocking DOE potential by selecting the most appropriate design for rAAV optimization.

Authors: Tzimou, Konstantina; Catalán-Tatjer, David; Nielsen, Lars K; Lavado-García, Jesús

Year: 2024

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2024.101329

Paper Harnessing design of experiments and automation significantly improves transient protein production in Chinese hamster ovary cells and accelerates drug discovery.

Ke, Jing; Li, Mandy; Yilmaz, Sultan et al. · 2026 · New biotechnology · DOI

Full title: Harnessing design of experiments and automation significantly improves transient protein production in Chinese hamster ovary cells and accelerates drug discovery.

Authors: Ke, Jing; Li, Mandy; Yilmaz, Sultan; Liu, Yan; Thi Thu Nguyen, Hang; Zhang, Pamela; Fayadat-Dilman, Laurence; Baker, Jeanne E

Year: 2026

Venue: New biotechnology

DOI: https://doi.org/10.1016/j.nbt.2026.01.010

Paper Combination of PAT and mechanistic modeling tools in a fully continuous powder to granule line: Rapid and deep process understanding

A. Domokos; É. Pusztai; L. Madarász et al. · 2021 · DOI

Full title: Combination of PAT and mechanistic modeling tools in a fully continuous powder to granule line: Rapid and deep process understanding

Authors: A. Domokos; É. Pusztai; L. Madarász; Brigitta Nagy; M. Gyürkés; A. Farkas; G. Fülöp; Tibor Casian; Botond Szilágyi; Z. Nagy

Year: 2021

DOI: https://doi.org/10.1016/j.powtec.2021.04.059

Paper Improving the heterologous expression of human β-defensin 2 (HBD2) using an experimental design.

Corrales-García, Ligia Luz; Serrano-Carreón, Leobardo; Corzo, Gerardo · 2020 · Protein expression and purification · DOI

Full title: Improving the heterologous expression of human β-defensin 2 (HBD2) using an experimental design.

Authors: Corrales-García, Ligia Luz; Serrano-Carreón, Leobardo; Corzo, Gerardo

Year: 2020

Venue: Protein expression and purification

DOI: https://doi.org/10.1016/j.pep.2019.105539

Paper A high-throughput protein refolding screen in 96-well format combined with design of experiments to optimize the refolding conditions.

Dechavanne, Vincent; Barrillat, Nicolas; Borlat, Frederic et al. · 2011 · Protein expression and purification · DOI

Full title: A high-throughput protein refolding screen in 96-well format combined with design of experiments to optimize the refolding conditions.

Authors: Dechavanne, Vincent; Barrillat, Nicolas; Borlat, Frederic; Hermant, Aurélie; Magnenat, Laurent; Paquet, Mikael; Antonsson, Bruno; Chevalet, Laurent

Year: 2011

Venue: Protein expression and purification

DOI: https://doi.org/10.1016/j.pep.2010.09.008

Paper Parametric optimization of solvent extraction of Jatropha curcas seed oil using design of experiment and its quality characterization

Yusuff, Adeyinka Sikiru · 2020 · South African Journal of Chemical Engineering · DOI

Full title: Parametric optimization of solvent extraction of Jatropha curcas seed oil using design of experiment and its quality characterization

Authors: Yusuff, Adeyinka Sikiru

Year: 2020

Venue: South African Journal of Chemical Engineering

DOI: https://doi.org/10.1016/j.sajce.2020.11.006

Paper A comparison of statistical approaches used for the optimization of soluble protein expression in Escherichia coli.

Papaneophytou, Christos; Kontopidis, George · 2016 · Protein expression and purification · DOI

Full title: A comparison of statistical approaches used for the optimization of soluble protein expression in Escherichia coli.

Authors: Papaneophytou, Christos; Kontopidis, George

Year: 2016

Venue: Protein expression and purification

DOI: https://doi.org/10.1016/j.pep.2015.12.014

Paper Optimization of the enrichment medium for recombinant ChIL-4-ChIL-2 in Lactococcus lactis through response surface methodology

Hao-yu Zhang; Yutong Yang; Xueqi Zhang et al. · 2025 · Poultry Science · DOI

Full title: Optimization of the enrichment medium for recombinant ChIL-4-ChIL-2 in Lactococcus lactis through response surface methodology

Authors: Hao-yu Zhang; Yutong Yang; Xueqi Zhang; Sichen Dong; Li-wen Wang; Ying-Ying Chen; Li Zhang; Xiaoling Lv; Ruichen Bai; Ming-xue Zheng

Year: 2025

Venue: Poultry Science

DOI: https://doi.org/10.1016/j.psj.2025.105025

Paper Machine Learning Optimization of Evolvable Artificial Cells

Filippo Caschera; S. Rasmussen; M. Hanczyc · 2011 · European Future Technologies Conference and Exhibition · DOI

Full title: Machine Learning Optimization of Evolvable Artificial Cells

Authors: Filippo Caschera; S. Rasmussen; M. Hanczyc

Year: 2011

Venue: European Future Technologies Conference and Exhibition

DOI: https://doi.org/10.1016/j.procs.2011.09.057

Paper Development and optimization of modified nucleosides and deoxynucleosides simultaneous extraction with the use of Design of Experiments approach

Małgorzata Artymowicz; S. Macioszek; J. Jacyna et al. · 2021 · DOI

Full title: Development and optimization of modified nucleosides and deoxynucleosides simultaneous extraction with the use of Design of Experiments approach

Authors: Małgorzata Artymowicz; S. Macioszek; J. Jacyna; Joanna Dawidowska; W. Struck-Lewicka; M. Markuszewski; D. Siluk

Year: 2021

DOI: https://doi.org/10.1016/j.scp.2021.100439

Paper Optimising cell-based bioassays via integrated design of experiments (ixDoE) - A practical guide.

Solzin, J; Eppler, K; Knapp, B et al. · 2023 · SLAS discovery : advancing life sciences R & D · DOI

Full title: Optimising cell-based bioassays via integrated design of experiments (ixDoE) - A practical guide.

Authors: Solzin, J; Eppler, K; Knapp, B; Buchner, H; Bluhmki, E

Year: 2023

Venue: SLAS discovery : advancing life sciences R & D

DOI: https://doi.org/10.1016/j.slasd.2022.10.004

Paper Improving an rRNA depletion protocol with statistical design of experiments.

David, Benjamin M; Jensen, Paul A · 2023 · SLAS technology · DOI

Full title: Improving an rRNA depletion protocol with statistical design of experiments.

Authors: David, Benjamin M; Jensen, Paul A

Year: 2023

Venue: SLAS technology

DOI: https://doi.org/10.1016/j.slast.2022.09.004

Paper Development and validation of a copper ligand-exchange chromatographic method for the estimation of D-lactic acid in Ringer-lactate solution.

Sharaf El-Din, Mohie M K; Attia, Khalid A M; Nassar, Mohamed W I et al. · 2018 · Talanta · DOI

Full title: Development and validation of a copper ligand-exchange chromatographic method for the estimation of D-lactic acid in Ringer-lactate solution.

Authors: Sharaf El-Din, Mohie M K; Attia, Khalid A M; Nassar, Mohamed W I; Kaddah, Mohamed M Y

Year: 2018

Venue: Talanta

DOI: https://doi.org/10.1016/j.talanta.2018.06.068

Paper A new statistical method for the automated detection of peaks in UV-DAD chromatograms of a sample mixture.

Debrus, Benjamin; Lebrun, Pierre; Ceccato, Attilio et al. · 2009 · Talanta · DOI

Full title: A new statistical method for the automated detection of peaks in UV-DAD chromatograms of a sample mixture.

Authors: Debrus, Benjamin; Lebrun, Pierre; Ceccato, Attilio; Caliaro, Gabriel; Govaerts, Bernadette; Olsen, Bernard A; Rozet, Eric; Boulanger, Bruno; Hubert, Philippe

Year: 2009

Venue: Talanta

DOI: https://doi.org/10.1016/j.talanta.2009.03.009

Paper Optimization of a pharmaceutical freeze-dried product and its process using an experimental design approach and innovative process analyzers.

De Beer, T R M; Wiggenhorn, M; Hawe, A et al. · 2011 · Talanta · DOI

Full title: Optimization of a pharmaceutical freeze-dried product and its process using an experimental design approach and innovative process analyzers.

Authors: De Beer, T R M; Wiggenhorn, M; Hawe, A; Kasper, J C; Almeida, A; Quinten, T; Friess, W; Winter, G; Vervaet, C; Remon, J P

Year: 2011

Venue: Talanta

DOI: https://doi.org/10.1016/j.talanta.2010.11.051

Paper Improving the reaction mix of a Pichia pastoris cell-free system using a design of experiments approach to minimise experimental effort.

Spice, Alex J; Aw, Rochelle; Bracewell, Daniel G et al. · 2020 · Synthetic and systems biotechnology · DOI

Full title: Improving the reaction mix of a Pichia pastoris cell-free system using a design of experiments approach to minimise experimental effort.

Authors: Spice, Alex J; Aw, Rochelle; Bracewell, Daniel G; Polizzi, Karen M

Year: 2020

Venue: Synthetic and systems biotechnology

DOI: https://doi.org/10.1016/j.synbio.2020.06.003

Paper Automated H2O2 monitoring during photo-Fenton processes using an Arduino self-assembled automatic system.

Antela, Kevin U; Palma, Davide; Morales-Rubio, Angel et al. · 2024 · Talanta · DOI

Full title: Automated H2O2 monitoring during photo-Fenton processes using an Arduino self-assembled automatic system.

Authors: Antela, Kevin U; Palma, Davide; Morales-Rubio, Angel; Cervera, M Luisa; Bianco Prevot, Alessandra

Year: 2024

Venue: Talanta

DOI: https://doi.org/10.1016/j.talanta.2024.126195

Paper Optimization of extraction conditions for LC-ToF-MS analysis of mevalonate pathway metabolites in engineered E. coli strain via statistical experimental designs.

Ng, Pnelope; Khoo, Leng Wei; Thong, Aaron et al. · 2023 · Talanta · DOI

Full title: Optimization of extraction conditions for LC-ToF-MS analysis of mevalonate pathway metabolites in engineered E. coli strain via statistical experimental designs.

Authors: Ng, Pnelope; Khoo, Leng Wei; Thong, Aaron; Chew, Wee

Year: 2023

Venue: Talanta

DOI: https://doi.org/10.1016/j.talanta.2022.124182

Paper Optimization of the castor fruit biomass chemical delignification by implementing the response surface methodology.

Reyes-Cruz, Federico Manuel; Sánchez-Cantú, Manuel; Rubio-Rosas, Efraín et al. · 2025 · Talanta · DOI

Full title: Optimization of the castor fruit biomass chemical delignification by implementing the response surface methodology.

Authors: Reyes-Cruz, Federico Manuel; Sánchez-Cantú, Manuel; Rubio-Rosas, Efraín; Quintana-Solórzano, Roberto

Year: 2025

Venue: Talanta

DOI: https://doi.org/10.1016/j.talanta.2025.127951

Paper Robustness testing of live attenuated rubella vaccine potency assay using fractional factorial design of experiments.

Kutle, Leonida; Pavlović, Nediljko; Dorotić, Marko et al. · 2010 · Vaccine · DOI

Full title: Robustness testing of live attenuated rubella vaccine potency assay using fractional factorial design of experiments.

Authors: Kutle, Leonida; Pavlović, Nediljko; Dorotić, Marko; Zadro, Ivana; Kapustić, Marijana; Halassy, Beata

Year: 2010

Venue: Vaccine

DOI: https://doi.org/10.1016/j.vaccine.2010.04.111

Paper Defining the multiplicity and time of infection for the production of Zaire Ebola virus-like particles in the insect cell-baculovirus expression system.

Pastor, Ana Ruth; González-Domínguez, Gonzalo; Díaz-Salinas, Marco A et al. · 2019 · Vaccine · DOI

Full title: Defining the multiplicity and time of infection for the production of Zaire Ebola virus-like particles in the insect cell-baculovirus expression system.

Authors: Pastor, Ana Ruth; González-Domínguez, Gonzalo; Díaz-Salinas, Marco A; Ramírez, Octavio T; Palomares, Laura A

Year: 2019

Venue: Vaccine

DOI: https://doi.org/10.1016/j.vaccine.2019.06.029

Paper Improving sensitivity for the targeted LC-MS/MS analysis of the peptide bradykinin using a design of experiments approach.

Gangnus, Tanja; Burckhardt, Bjoern B · 2020 · Talanta · DOI

Full title: Improving sensitivity for the targeted LC-MS/MS analysis of the peptide bradykinin using a design of experiments approach.

Authors: Gangnus, Tanja; Burckhardt, Bjoern B

Year: 2020

Venue: Talanta

DOI: https://doi.org/10.1016/j.talanta.2020.121134

Paper Polyethylenimine mediated recovery of SARS-CoV-2 and total viral RNA: Impact of aqueous conditions on behaviour and recovery.

Mullins, Nathan; Alashraf, Abdul Rahman; McDermott, Kevin et al. · 2024 · Water research · DOI

Full title: Polyethylenimine mediated recovery of SARS-CoV-2 and total viral RNA: Impact of aqueous conditions on behaviour and recovery.

Authors: Mullins, Nathan; Alashraf, Abdul Rahman; McDermott, Kevin; Brown, R Stephen; Payne, Sarah Jane

Year: 2024

Venue: Water research

DOI: https://doi.org/10.1016/j.watres.2024.121207

Paper Combined semi-empirical screening and design of experiments (DOE) approach to identify candidate formulations of a lyophilized live attenuated tetravalent viral vaccine candidate.

Patel, Ashaben; Erb, Steven M; Strange, Linda et al. · 2018 · Vaccine · DOI

Full title: Combined semi-empirical screening and design of experiments (DOE) approach to identify candidate formulations of a lyophilized live attenuated tetravalent viral vaccine candidate.

Authors: Patel, Ashaben; Erb, Steven M; Strange, Linda; Shukla, Ravi S; Kumru, Ozan S; Smith, Lee; Nelson, Paul; Joshi, Sangeeta B; Livengood, Jill A; Volkin, David B

Year: 2018

Venue: Vaccine

DOI: https://doi.org/10.1016/j.vaccine.2017.04.086

Paper Accelerating bioprocess development by analysis of all available data: A USP case study.

Suarez-Zuluaga, Diego A; Borchert, Daniel; Driessen, Nicole N et al. · 2019 · Vaccine · DOI

Full title: Accelerating bioprocess development by analysis of all available data: A USP case study.

Authors: Suarez-Zuluaga, Diego A; Borchert, Daniel; Driessen, Nicole N; Bakker, Wilfried A M; Thomassen, Yvonne E

Year: 2019

Venue: Vaccine

DOI: https://doi.org/10.1016/j.vaccine.2019.07.026

Paper Targeting phosphorus recovery strategies for activated sludge: DoE and multi-objective optimisation to analyse key process factors and associated costs.

Boniardi, Gaia; Rackham, Paige; Gan, Albie et al. · 2026 · Water research · DOI

Full title: Targeting phosphorus recovery strategies for activated sludge: DoE and multi-objective optimisation to analyse key process factors and associated costs.

Authors: Boniardi, Gaia; Rackham, Paige; Gan, Albie; Oehmen, Adrian

Year: 2026

Venue: Water research

DOI: https://doi.org/10.1016/j.watres.2025.124670

Paper An Experimental-Based Approach to Construct the Process Design Space of a Freeze-Drying Process: An Effective Tool to Design an Optimum and Robust Freeze-Drying Process for Pharmaceuticals.

Assegehegn, Getachew; Brito-de la Fuente, Edmundo; Franco, José M et al. · 2020 · Journal of pharmaceutical sciences · DOI

Full title: An Experimental-Based Approach to Construct the Process Design Space of a Freeze-Drying Process: An Effective Tool to Design an Optimum and Robust Freeze-Drying Process for Pharmaceuticals.

Authors: Assegehegn, Getachew; Brito-de la Fuente, Edmundo; Franco, José M; Gallegos, Críspulo

Year: 2020

Venue: Journal of pharmaceutical sciences

DOI: https://doi.org/10.1016/j.xphs.2019.07.001

Paper Application of advanced quantification techniques in nanoparticle-based vaccine development with the Sf9 cell baculovirus expression system.

Puente-Massaguer, Eduard; Lecina, Martí; Gòdia, Francesc · 2020 · Vaccine · DOI

Full title: Application of advanced quantification techniques in nanoparticle-based vaccine development with the Sf9 cell baculovirus expression system.

Authors: Puente-Massaguer, Eduard; Lecina, Martí; Gòdia, Francesc

Year: 2020

Venue: Vaccine

DOI: https://doi.org/10.1016/j.vaccine.2019.11.087

Paper Near-Infrared Spectroscopy to Determine Residual Moisture in Freeze-Dried Products: Model Generation by Statistical Design of Experiments.

Clavaud, Matthieu; Lema-Martinez, Carmen; Roggo, Yves et al. · 2020 · Journal of pharmaceutical sciences · DOI

Full title: Near-Infrared Spectroscopy to Determine Residual Moisture in Freeze-Dried Products: Model Generation by Statistical Design of Experiments.

Authors: Clavaud, Matthieu; Lema-Martinez, Carmen; Roggo, Yves; Bigalke, Michael; Guillemain, Aurélie; Hubert, Philippe; Ziemons, Eric; Allmendinger, Andrea

Year: 2020

Venue: Journal of pharmaceutical sciences

DOI: https://doi.org/10.1016/j.xphs.2019.08.028

Paper Increasing the Robustness of Biopharmaceutical Precipitation Assays - Part I: Derivative UV Spectrophotometric Method Development for in-line Measurements.

Lehmann, Andreas; Krollik, Katharina; Beran, Kristian et al. · 2022 · Journal of pharmaceutical sciences · DOI

Full title: Increasing the Robustness of Biopharmaceutical Precipitation Assays - Part I: Derivative UV Spectrophotometric Method Development for in-line Measurements.

Authors: Lehmann, Andreas; Krollik, Katharina; Beran, Kristian; Hirtreiter, Carina; Kubas, Holger; Wagner, Christian

Year: 2022

Venue: Journal of pharmaceutical sciences

DOI: https://doi.org/10.1016/j.xphs.2021.08.025

Paper Algorithm-Based Liquid Formulation Development Including a DoE Concept Predicts Long-Term Viral Vector Stability.

Reinauer, Eva B; Grosso, Stella S; Henz, Stefan R et al. · 2020 · Journal of pharmaceutical sciences · DOI

Full title: Algorithm-Based Liquid Formulation Development Including a DoE Concept Predicts Long-Term Viral Vector Stability.

Authors: Reinauer, Eva B; Grosso, Stella S; Henz, Stefan R; Rabas, Julia A; Rodenstein, Carina; Altrichter, Jens; Scholz, Martin; Kemter, Kristina F

Year: 2020

Venue: Journal of pharmaceutical sciences

DOI: https://doi.org/10.1016/j.xphs.2019.10.063

Paper A simple, robust and highly efficient transient expression system for producing antibodies.

Vink, Tom; Oudshoorn-Dickmann, Maroeska; Roza, Marcel et al. · 2014 · Methods (San Diego, Calif.) · DOI

Full title: A simple, robust and highly efficient transient expression system for producing antibodies.

Authors: Vink, Tom; Oudshoorn-Dickmann, Maroeska; Roza, Marcel; Reitsma, Jelte-Jan; de Jong, Rob N

Year: 2014

Venue: Methods (San Diego, Calif.)

DOI: https://doi.org/10.1016/j.ymeth.2013.07.018

Paper Preparation of Nanoemulsions by Premix Membrane Emulsification: Which Parameters Have a Significant Influence on the Resulting Particle Size?

Gehrmann, Sandra; Bunjes, Heike · 2017 · Journal of pharmaceutical sciences · DOI

Full title: Preparation of Nanoemulsions by Premix Membrane Emulsification: Which Parameters Have a Significant Influence on the Resulting Particle Size?

Authors: Gehrmann, Sandra; Bunjes, Heike

Year: 2017

Venue: Journal of pharmaceutical sciences

DOI: https://doi.org/10.1016/j.xphs.2017.04.066

Paper Material-Sparing Approach using Differential Scanning Calorimeter and Response Surface Methodology for Process Optimization of Hot-Melt Extrusion.

Mamidi, Hemanth K; Rohera, Bhagwan D · 2021 · Journal of pharmaceutical sciences · DOI

Full title: Material-Sparing Approach using Differential Scanning Calorimeter and Response Surface Methodology for Process Optimization of Hot-Melt Extrusion.

Authors: Mamidi, Hemanth K; Rohera, Bhagwan D

Year: 2021

Venue: Journal of pharmaceutical sciences

DOI: https://doi.org/10.1016/j.xphs.2021.08.031

Paper Formulation Development of Doxycycline-Loaded Lipid Nanocarriers using Microfluidics by QbD Approach.

Lee, Chia Ying; Su, Chi-Ting; Tsai, Tsuimin et al. · 2023 · Journal of pharmaceutical sciences · DOI

Full title: Formulation Development of Doxycycline-Loaded Lipid Nanocarriers using Microfluidics by QbD Approach.

Authors: Lee, Chia Ying; Su, Chi-Ting; Tsai, Tsuimin; Hsieh, Chien-Ming; Hung, Kuan-Yu; Huang, Jeng-Wen; Chen, Chin-Tin

Year: 2023

Venue: Journal of pharmaceutical sciences

DOI: https://doi.org/10.1016/j.xphs.2022.09.023

Paper Thermodynamics-based Metabolite Sensitivity Analysis in metabolic networks.

Kiparissides, A; Hatzimanikatis, V · 2017 · Metabolic engineering · DOI

Full title: Thermodynamics-based Metabolite Sensitivity Analysis in metabolic networks.

Authors: Kiparissides, A; Hatzimanikatis, V

Year: 2017

Venue: Metabolic engineering

DOI: https://doi.org/10.1016/j.ymben.2016.11.006

Paper Iterative algorithm-guided design of massive strain libraries, applied to itaconic acid production in yeast.

Young, Eric M; Zhao, Zheng; Gielesen, Bianca E M et al. · 2018 · Metabolic engineering · DOI

Full title: Iterative algorithm-guided design of massive strain libraries, applied to itaconic acid production in yeast.

Authors: Young, Eric M; Zhao, Zheng; Gielesen, Bianca E M; Wu, Liang; Benjamin Gordon, D; Roubos, Johannes A; Voigt, Christopher A

Year: 2018

Venue: Metabolic engineering

DOI: https://doi.org/10.1016/j.ymben.2018.05.002

Paper Optimization of isoamyl acetate production by using immobilized lipase from Mucor miehei by response surface methodology.

Hari Krishna S; Manohar, B; Divakar, S et al. · 2000 · Enzyme and microbial technology · DOI

Full title: Optimization of isoamyl acetate production by using immobilized lipase from Mucor miehei by response surface methodology.

Authors: Hari Krishna S; Manohar, B; Divakar, S; Prapulla, SG; Karanth, NG

Year: 2000

Venue: Enzyme and microbial technology

DOI: https://doi.org/10.1016/s0141-0229(99)00149-0

Paper Design of experiments for capillary electrophoretic enantioresolution of salbutamol using dermatan sulfate.

Gotti, R; Furlanetto, S; Andrisano, V et al. · 2000 · Journal of chromatography. A · DOI

Full title: Design of experiments for capillary electrophoretic enantioresolution of salbutamol using dermatan sulfate.

Authors: Gotti, R; Furlanetto, S; Andrisano, V; Cavrini, V; Pinzauti, S

Year: 2000

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/s0021-9673(99)01303-5

Paper Attractive design: an elution solvent optimization platform for magnetic-bead-based fractionation using digital microfluidics and design of experiments.

Lafrenière, Nelson M; Mudrik, Jared M; Ng, Alphonsus H C et al. · 2015 · Analytical chemistry · DOI

Full title: Attractive design: an elution solvent optimization platform for magnetic-bead-based fractionation using digital microfluidics and design of experiments.

Authors: Lafrenière, Nelson M; Mudrik, Jared M; Ng, Alphonsus H C; Seale, Brendon; Spooner, Neil; Wheeler, Aaron R

Year: 2015

Venue: Analytical chemistry

DOI: https://doi.org/10.1021/ac504697r

Paper I-Optimal Design of Hierarchical 3D Scaffolds Produced by Combining Additive Manufacturing and Thermally Induced Phase Separation.

Yousefi, Azizeh-Mitra; Liu, Junyi; Sheppard, Riley et al. · 2019 · ACS applied bio materials · DOI

Full title: I-Optimal Design of Hierarchical 3D Scaffolds Produced by Combining Additive Manufacturing and Thermally Induced Phase Separation.

Authors: Yousefi, Azizeh-Mitra; Liu, Junyi; Sheppard, Riley; Koo, Songmi; Silverstein, Joshua; Zhang, Jing; James, Paul F

Year: 2019

Venue: ACS applied bio materials

DOI: https://doi.org/10.1021/acsabm.8b00534

Paper Predictive Model for the Design of Zwitterionic Polymer Brushes: A Statistical Design of Experiments Approach.

Kumar, Ramya; Lahann, Joerg · 2016 · ACS applied materials & interfaces · DOI

Full title: Predictive Model for the Design of Zwitterionic Polymer Brushes: A Statistical Design of Experiments Approach.

Authors: Kumar, Ramya; Lahann, Joerg

Year: 2016

Venue: ACS applied materials & interfaces

DOI: https://doi.org/10.1021/acsami.6b04370

Paper Development of generic liquid chromatography-mass spectrometry methods using experimental design.

Seto, Carmai; Bateman, Kevin P; Gunter, Berton · 2002 · Journal of the American Society for Mass Spectrometry · DOI

Full title: Development of generic liquid chromatography-mass spectrometry methods using experimental design.

Authors: Seto, Carmai; Bateman, Kevin P; Gunter, Berton

Year: 2002

Venue: Journal of the American Society for Mass Spectrometry

DOI: https://doi.org/10.1016/S1044-0305(01)00334-8

Paper Time-Saving Design of Experiment Protocol for Optimization of LC-MS Data Processing in Metabolomic Approaches

Zheng, Hong; Clausen, Morten Rahr; Dalsgaard, Trine Kastrup et al. · 2013 · Analytical Chemistry · DOI

Full title: Time-Saving Design of Experiment Protocol for Optimization of LC-MS Data Processing in Metabolomic Approaches

Authors: Zheng, Hong; Clausen, Morten Rahr; Dalsgaard, Trine Kastrup; Mortensen, Grith; Bertram, Hanne Christine

Year: 2013

Venue: Analytical Chemistry

DOI: https://doi.org/10.1021/ac4020325

Paper Automated digital microfluidic platform for magnetic-particle-based immunoassays with optimization by design of experiments.

Choi, Kihwan; Ng, Alphonsus H C; Fobel, Ryan et al. · 2013 · Analytical chemistry · DOI

Full title: Automated digital microfluidic platform for magnetic-particle-based immunoassays with optimization by design of experiments.

Authors: Choi, Kihwan; Ng, Alphonsus H C; Fobel, Ryan; Chang-Yen, David A; Yarnell, Lyle E; Pearson, Elroy L; Oleksak, Carl M; Fischer, Andrew T; Luoma, Robert P; Robinson, John M; Audet, Julie; Wheeler, Aaron R

Year: 2013

Venue: Analytical chemistry

DOI: https://doi.org/10.1021/ac401847x

Paper Microfluidic Manufacturing of Liposomes: Development and Optimization by Design of Experiment and Machine Learning.

Rebollo, René; Oyoun, Feras; Corvis, Yohann et al. · 2022 · ACS applied materials & interfaces · DOI

Full title: Microfluidic Manufacturing of Liposomes: Development and Optimization by Design of Experiment and Machine Learning.

Authors: Rebollo, René; Oyoun, Feras; Corvis, Yohann; El-Hammadi, Mazen M; Saubamea, Bruno; Andrieux, Karine; Mignet, Nathalie; Alhareth, Khair

Year: 2022

Venue: ACS applied materials & interfaces

DOI: https://doi.org/10.1021/acsami.2c06627

Paper Generalized Subset Designs in Analytical Chemistry.

Surowiec, Izabella; Vikström, Ludvig; Hector, Gustaf et al. · 2017 · Analytical chemistry · DOI

Full title: Generalized Subset Designs in Analytical Chemistry.

Authors: Surowiec, Izabella; Vikström, Ludvig; Hector, Gustaf; Johansson, Erik; Vikström, Conny; Trygg, Johan

Year: 2017

Venue: Analytical chemistry

DOI: https://doi.org/10.1021/acs.analchem.7b00506

Paper Optimization of a Dissolvable Lipid Nanoparticle Microneedle Formulation for mRNA Delivery Using Design of Experiments.

Zhao, Yayi; Zhang, Qizheng; Hu, Tianli et al. · 2025 · ACS applied materials & interfaces · DOI

Full title: Optimization of a Dissolvable Lipid Nanoparticle Microneedle Formulation for mRNA Delivery Using Design of Experiments.

Authors: Zhao, Yayi; Zhang, Qizheng; Hu, Tianli; Kuwentrai, Chaiyaporn; Zhang, Ye; Huang, Jian-Dong; Kuang, Yi; Xu, Chenjie

Year: 2025

Venue: ACS applied materials & interfaces

DOI: https://doi.org/10.1021/acsami.5c05528

Paper Continuous Processing for Manufacturing of Antibody-Drug Conjugates (ADCs).

Metya, Subhankar; Prakash, Pragya; Rathore, Anurag S · 2026 · Bioconjugate chemistry · DOI

Full title: Continuous Processing for Manufacturing of Antibody-Drug Conjugates (ADCs).

Authors: Metya, Subhankar; Prakash, Pragya; Rathore, Anurag S

Year: 2026

Venue: Bioconjugate chemistry

DOI: https://doi.org/10.1021/acs.bioconjchem.5c00599

Paper Simple and Effective Way for Data Preprocessing Selection Based on Design of Experiments

Gerretzen, Jan; Szymańska, Ewa; Jansen, Jeroen J. et al. · 2015 · Analytical Chemistry · DOI

Full title: Simple and Effective Way for Data Preprocessing Selection Based on Design of Experiments

Authors: Gerretzen, Jan; Szymańska, Ewa; Jansen, Jeroen J.; Bart, Jacob; Manen, Henk‐Jan van; Heuvel, Edwin R. van den; Buydens, L.M.C.

Year: 2015

Venue: Analytical Chemistry

DOI: https://doi.org/10.1021/acs.analchem.5b02832

Paper Definitive Screening Design Optimization of Mass Spectrometry Parameters for Sensitive Comparison of Filter and Solid Phase Extraction Purified, INLIGHT Plasma N-Glycans.

Hecht, Elizabeth S; McCord, James P; Muddiman, David C · 2015 · Analytical chemistry · DOI

Full title: Definitive Screening Design Optimization of Mass Spectrometry Parameters for Sensitive Comparison of Filter and Solid Phase Extraction Purified, INLIGHT Plasma N-Glycans.

Authors: Hecht, Elizabeth S; McCord, James P; Muddiman, David C

Year: 2015

Venue: Analytical chemistry

DOI: https://doi.org/10.1021/acs.analchem.5b01609

Paper Rapid Method Development in Hydrophilic Interaction Liquid Chromatography for Pharmaceutical Analysis Using a Combination of Quantitative Structure-Retention Relationships and Design of Experiments.

Taraji, Maryam; Haddad, Paul R; Amos, Ruth I J et al. · 2017 · Analytical chemistry · DOI

Full title: Rapid Method Development in Hydrophilic Interaction Liquid Chromatography for Pharmaceutical Analysis Using a Combination of Quantitative Structure-Retention Relationships and Design of Experiments.

Authors: Taraji, Maryam; Haddad, Paul R; Amos, Ruth I J; Talebi, Mohammad; Szucs, Roman; Dolan, John W; Pohl, Chris A

Year: 2017

Venue: Analytical chemistry

DOI: https://doi.org/10.1021/acs.analchem.6b04282

Paper Chemometrics-Assisted Enhancement of Electrochemical Biosensor Performance toward miRNA Detection.

Cimmino, Wanda; Esposito, Simona; Kalligosfyri, Panagiota M et al. · 2025 · Analytical chemistry · DOI

Full title: Chemometrics-Assisted Enhancement of Electrochemical Biosensor Performance toward miRNA Detection.

Authors: Cimmino, Wanda; Esposito, Simona; Kalligosfyri, Panagiota M; Iaccarino, Nunzia; Cinti, Stefano

Year: 2025

Venue: Analytical chemistry

DOI: https://doi.org/10.1021/acs.analchem.4c05402

Paper Plasmid DNA Delivery Using a Stable Nanovesicle Platform: A Design-of-Experiments-Guided Investigation.

Köber, Mariana; González-Domínguez, Irene; Valdospinos, Diego et al. · 2026 · ACS biomaterials science & engineering · DOI

Full title: Plasmid DNA Delivery Using a Stable Nanovesicle Platform: A Design-of-Experiments-Guided Investigation.

Authors: Köber, Mariana; González-Domínguez, Irene; Valdospinos, Diego; Puente-Massaguer, Eduard; Piqué-Ponti, Júlia; Piña, David; Avilés-Domínguez, Laia; Boloix, Ariadna; Segura, Miguel F; Ventosa, Nora; Gòdia, Francesc

Year: 2026

Venue: ACS biomaterials science & engineering

DOI: https://doi.org/10.1021/acsbiomaterials.5c01328

Paper A Design of Experiment Rational Optimization of the Degumming Process and Its Impact on the Silk Fibroin Properties

Bucciarelli, Alessio; Greco, Gabriele; Corridori, Ilaria et al. · 2021 · ACS Biomaterials Science & Engineering · DOI

Full title: A Design of Experiment Rational Optimization of the Degumming Process and Its Impact on the Silk Fibroin Properties

Authors: Bucciarelli, Alessio; Greco, Gabriele; Corridori, Ilaria; Pugno, Nicola M.; Motta, Antonella

Year: 2021

Venue: ACS Biomaterials Science & Engineering

DOI: https://doi.org/10.1021/acsbiomaterials.0c01657

Paper Crystallization Diagram for Antisolvent Crystallization of Lactose: Using Design of Experiments To Investigate Continuous Mixing-Induced Supersaturation

MacFhionnghaile, Pól; Svoboda, Václav; McGinty, John et al. · 2017 · Crystal Growth & Design · DOI

Full title: Crystallization Diagram for Antisolvent Crystallization of Lactose: Using Design of Experiments To Investigate Continuous Mixing-Induced Supersaturation

Authors: MacFhionnghaile, Pól; Svoboda, Václav; McGinty, John; Nordon, Alison; Šefčı́k, Ján

Year: 2017

Venue: Crystal Growth & Design

DOI: https://doi.org/10.1021/acs.cgd.7b00136

Paper Comparative Study on Adaptive Bayesian Optimization for Batch Cooling Crystallization for Slow and Fast Kinetic Regimes.

Pickles, Thomas; Mustoe, Chantal; Brown, Cameron J et al. · 2024 · Crystal growth & design · DOI

Full title: Comparative Study on Adaptive Bayesian Optimization for Batch Cooling Crystallization for Slow and Fast Kinetic Regimes.

Authors: Pickles, Thomas; Mustoe, Chantal; Brown, Cameron J; Florence, Alastair J

Year: 2024

Venue: Crystal growth & design

DOI: https://doi.org/10.1021/acs.cgd.3c01225

Paper Factorial Design of Experiments to Optimize Multiple Protein Delivery for Cardiac Repair.

Awada, Hassan K; Johnson, Louis A; Hitchens, T Kevin et al. · 2016 · ACS biomaterials science & engineering · DOI

Full title: Factorial Design of Experiments to Optimize Multiple Protein Delivery for Cardiac Repair.

Authors: Awada, Hassan K; Johnson, Louis A; Hitchens, T Kevin; Foley, Lesley M; Wang, Yadong

Year: 2016

Venue: ACS biomaterials science & engineering

DOI: https://doi.org/10.1021/acsbiomaterials.6b00146

Paper Experimental Design of Formulations Utilizing High Dimensional Model Representation.

Li, Genyuan; Bastian, Caleb; Welsh, William et al. · 2015 · The journal of physical chemistry. A · DOI

Full title: Experimental Design of Formulations Utilizing High Dimensional Model Representation.

Authors: Li, Genyuan; Bastian, Caleb; Welsh, William; Rabitz, Herschel

Year: 2015

Venue: The journal of physical chemistry. A

DOI: https://doi.org/10.1021/acs.jpca.5b04911

Paper Sequential Model-Based A-Optimal Design of Experiments When the Fisher Information Matrix Is Noninvertible

Shahmohammadi, Ali; McAuley, Kimberley B. · 2018 · Industrial & Engineering Chemistry Research · DOI

Full title: Sequential Model-Based A-Optimal Design of Experiments When the Fisher Information Matrix Is Noninvertible

Authors: Shahmohammadi, Ali; McAuley, Kimberley B.

Year: 2018

Venue: Industrial & Engineering Chemistry Research

DOI: https://doi.org/10.1021/acs.iecr.8b03047

Paper The Promising Prospective Technology for Biofuel Production with Mixed Cultures Using Sorghum Grain (Sorghum bicolor (L.) Moench) Grown in a Temperate Climate: Characteristics of Fermentation Factors and Volatile Compounds Analysis.

Szambelan, Katarzyna; Jeleń, Henryk; Nowak, Jacek et al. · 2025 · Journal of agricultural and food chemistry · DOI

Full title: The Promising Prospective Technology for Biofuel Production with Mixed Cultures Using Sorghum Grain (Sorghum bicolor (L.) Moench) Grown in a Temperate Climate: Characteristics of Fermentation Factors and Volatile Compounds Analysis.

Authors: Szambelan, Katarzyna; Jeleń, Henryk; Nowak, Jacek; Frankowski, Jakub; Szwengiel, Artur

Year: 2025

Venue: Journal of agricultural and food chemistry

DOI: https://doi.org/10.1021/acs.jafc.5c02582

Paper Characterization of Lipid Nanoparticles Containing Ionizable Cationic Lipids Using Design-of-Experiments Approach

Terada, T.; Kulkarni, Jayesh A.; Huynh, Ariel et al. · 2021 · Langmuir · DOI

Full title: Characterization of Lipid Nanoparticles Containing Ionizable Cationic Lipids Using Design-of-Experiments Approach

Authors: Terada, T.; Kulkarni, Jayesh A.; Huynh, Ariel; Chen, Sam; Meel, Roy van der; Tam, Yuen Yi C.; Cullis, Pieter R.

Year: 2021

Venue: Langmuir

DOI: https://doi.org/10.1021/acs.langmuir.0c03039

Paper Implementation and Application of Model-Based Design of Experiments in a Flowsheet Simulator

Asprion, Norbert; Böttcher, Roger; Mairhofer, Jonas et al. · 2019 · Journal of Chemical & Engineering Data · DOI

Full title: Implementation and Application of Model-Based Design of Experiments in a Flowsheet Simulator

Authors: Asprion, Norbert; Böttcher, Roger; Mairhofer, Jonas; Yliruka, Maria; Höller, Johannes; Schwientek, Jan; Vanaret, Charlie; Bortz, Michael

Year: 2019

Venue: Journal of Chemical & Engineering Data

DOI: https://doi.org/10.1021/acs.jced.9b00494

Paper Closed-Loop Model-Based Design of Experiments for Kinetic Model Discrimination and Parameter Estimation: Benzoic Acid Esterification on a Heterogeneous Catalyst

Waldron, Conor; Pankajakshan, Arun; Quaglio, Marco et al. · 2019 · Industrial & Engineering Chemistry Research · DOI

Full title: Closed-Loop Model-Based Design of Experiments for Kinetic Model Discrimination and Parameter Estimation: Benzoic Acid Esterification on a Heterogeneous Catalyst

Authors: Waldron, Conor; Pankajakshan, Arun; Quaglio, Marco; Cao, Enhong; Galvanin, Federico; Gavriilidis, Asterios

Year: 2019

Venue: Industrial & Engineering Chemistry Research

DOI: https://doi.org/10.1021/acs.iecr.9b04089

Paper The Skin You Are In: Design-of-Experiments Optimization of Lipid Nanoparticle Self-Amplifying RNA Formulations in Human Skin Explants.

Blakney, Anna K; McKay, Paul F; Ibarzo Yus, Bárbara et al. · 2019 · ACS nano · DOI

Full title: The Skin You Are In: Design-of-Experiments Optimization of Lipid Nanoparticle Self-Amplifying RNA Formulations in Human Skin Explants.

Authors: Blakney, Anna K; McKay, Paul F; Ibarzo Yus, Bárbara; Hunter, Judith E; Dex, Elizabeth A; Shattock, Robin J

Year: 2019

Venue: ACS nano

DOI: https://doi.org/10.1021/acsnano.9b01774

Paper Efficient Process Development of Abiraterone Acetate by Employing Design of Experiments.

Komati, Shravan Kumar; Madhra, Mukesh Kumar; Manda, Amarendhar et al. · 2024 · ACS omega · DOI

Full title: Efficient Process Development of Abiraterone Acetate by Employing Design of Experiments.

Authors: Komati, Shravan Kumar; Madhra, Mukesh Kumar; Manda, Amarendhar; Venkata Annapurna, Sasikala Cheemalapati; Senadi, Gopal Chandru; Maruthapillai, Arthanareeswari; Bandichhor, Rakeshwar

Year: 2024

Venue: ACS omega

DOI: https://doi.org/10.1021/acsomega.4c01912

Paper Optimization of Lipid Nanoparticles for saRNA Expression and Cellular Activation Using a Design-of-Experiment Approach.

Ly, Han Han; Daniel, Simon; Soriano, Shekinah K V et al. · 2022 · Molecular pharmaceutics · DOI

Full title: Optimization of Lipid Nanoparticles for saRNA Expression and Cellular Activation Using a Design-of-Experiment Approach.

Authors: Ly, Han Han; Daniel, Simon; Soriano, Shekinah K V; Kis, Zoltán; Blakney, Anna K

Year: 2022

Venue: Molecular pharmaceutics

DOI: https://doi.org/10.1021/acs.molpharmaceut.2c00032

Paper High-Throughput Automated Design of Experiment (DoE) and Kinetic Modeling to Aid in Process Development of an API

Nunn, Christopher J.; DiPietro, Andrew; Hodnett, Neil S. et al. · 2017 · Organic Process Research & Development · DOI

Full title: High-Throughput Automated Design of Experiment (DoE) and Kinetic Modeling to Aid in Process Development of an API

Authors: Nunn, Christopher J.; DiPietro, Andrew; Hodnett, Neil S.; Sun, Pu; Wells, Kenneth M.

Year: 2017

Venue: Organic Process Research & Development

DOI: https://doi.org/10.1021/acs.oprd.7b00295

Paper Stability-Focused Nanoparticle Development: Applying Particle Size Stability as a Response Factor in the Design of Experiments.

Muccelin, Vanessa V B; Vellozo, Otavio C; Valente, Thais L et al. · 2025 · ACS omega · DOI

Full title: Stability-Focused Nanoparticle Development: Applying Particle Size Stability as a Response Factor in the Design of Experiments.

Authors: Muccelin, Vanessa V B; Vellozo, Otavio C; Valente, Thais L; Pupe, Carolina G; Carvalho, Edison L S; Detoni, Cassia B

Year: 2025

Venue: ACS omega

DOI: https://doi.org/10.1021/acsomega.5c00613

Paper From Synthesis to Application: Functionalized Magnetic Nanoparticles as a Simple and Reliable Tool for Nucleic Acid Purification.

Ribeiro, Iuly Guimarães; Silva, Thais de Andrade; Barizão, Ana Carolina de Lima et al. · 2026 · ACS omega · DOI

Full title: From Synthesis to Application: Functionalized Magnetic Nanoparticles as a Simple and Reliable Tool for Nucleic Acid Purification.

Authors: Ribeiro, Iuly Guimarães; Silva, Thais de Andrade; Barizão, Ana Carolina de Lima; Paganoto, Giordano Toscano; Dos Santos, Gabriel Fernandes Souza; Cassini, Sérvio Tulio Alves; Guimarães, Marco Cesar Cunegundes; de Oliveira, Jairo Pinto

Year: 2026

Venue: ACS omega

DOI: https://doi.org/10.1021/acsomega.5c06432

Paper Flash Thermal Racemization of Chiral Amine in Continuous Flow: An Exploration of Reaction Space Using DoE and Multivariate Transient Flow.

Takle, Matthew J; Schrecker, Linden; Deadman, Benjamin J et al. · 2025 · Organic process research & development · DOI

Full title: Flash Thermal Racemization of Chiral Amine in Continuous Flow: An Exploration of Reaction Space Using DoE and Multivariate Transient Flow.

Authors: Takle, Matthew J; Schrecker, Linden; Deadman, Benjamin J; Dickhaut, Joachim; Wieja, Andy; Hellgardt, Klaus; Mimi Hii, King Kuok

Year: 2025

Venue: Organic process research & development

DOI: https://doi.org/10.1021/acs.oprd.4c00508

Paper A Customized Bayesian Algorithm to Optimize Enzyme-Catalyzed Reactions.

Tachibana, Ryo; Zhang, Kailin; Zou, Zhi et al. · 2023 · ACS sustainable chemistry & engineering · DOI

Full title: A Customized Bayesian Algorithm to Optimize Enzyme-Catalyzed Reactions.

Authors: Tachibana, Ryo; Zhang, Kailin; Zou, Zhi; Burgener, Simon; Ward, Thomas R

Year: 2023

Venue: ACS sustainable chemistry & engineering

DOI: https://doi.org/10.1021/acssuschemeng.3c02402

Paper Development of High-Performance Whole Cell Biosensors Aided by Statistical Modeling.

Berepiki, Adokiye; Kent, Ross; Machado, Leopoldo F M et al. · 2020 · ACS synthetic biology · DOI

Full title: Development of High-Performance Whole Cell Biosensors Aided by Statistical Modeling.

Authors: Berepiki, Adokiye; Kent, Ross; Machado, Leopoldo F M; Dixon, Neil

Year: 2020

Venue: ACS synthetic biology

DOI: https://doi.org/10.1021/acssynbio.9b00448

Paper Design-Build-Test-Learn-Guided Engineering of a Whole-Cell Pyruvate Biosensor Based on a Transcription Factor.

Gao, Zihan; Suarez-Diez, Maria; Candry, Pieter · 2026 · ACS synthetic biology · DOI

Full title: Design-Build-Test-Learn-Guided Engineering of a Whole-Cell Pyruvate Biosensor Based on a Transcription Factor.

Authors: Gao, Zihan; Suarez-Diez, Maria; Candry, Pieter

Year: 2026

Venue: ACS synthetic biology

DOI: https://doi.org/10.1021/acssynbio.5c00650

Paper Design of Experiments Methodology to Build a Multifactorial Statistical Model Describing the Metabolic Interactions of Alcohol Dehydrogenase Isozymes in the Ethanol Biosynthetic Pathway of the Yeast Saccharomyces cerevisiae.

Brown, Steven R; Staff, Marta; Lee, Rob et al. · 2018 · ACS synthetic biology · DOI

Full title: Design of Experiments Methodology to Build a Multifactorial Statistical Model Describing the Metabolic Interactions of Alcohol Dehydrogenase Isozymes in the Ethanol Biosynthetic Pathway of the Yeast Saccharomyces cerevisiae.

Authors: Brown, Steven R; Staff, Marta; Lee, Rob; Love, John; Parker, David A; Aves, Stephen J; Howard, Thomas P

Year: 2018

Venue: ACS synthetic biology

DOI: https://doi.org/10.1021/acssynbio.8b00112

Paper Double Dutch: A Tool for Designing Combinatorial Libraries of Biological Systems.

Roehner, Nicholas; Young, Eric M; Voigt, Christopher A et al. · 2016 · ACS synthetic biology · DOI

Full title: Double Dutch: A Tool for Designing Combinatorial Libraries of Biological Systems.

Authors: Roehner, Nicholas; Young, Eric M; Voigt, Christopher A; Gordon, D Benjamin; Densmore, Douglas

Year: 2016

Venue: ACS synthetic biology

DOI: https://doi.org/10.1021/acssynbio.5b00232

Paper Analysis of Design of Experiments with Dynamic Responses

Domagalski, Nathan; Mack, Brendan; Tábora, José E. · 2015 · Organic Process Research & Development · DOI

Full title: Analysis of Design of Experiments with Dynamic Responses

Authors: Domagalski, Nathan; Mack, Brendan; Tábora, José E.

Year: 2015

Venue: Organic Process Research & Development

DOI: https://doi.org/10.1021/acs.oprd.5b00143

Paper Improving Metabolic Pathway Efficiency by Statistical Model-Based Multivariate Regulatory Metabolic Engineering.

Xu, Peng; Rizzoni, Elizabeth Anne; Sul, Se-Yeong et al. · 2017 · ACS synthetic biology · DOI

Full title: Improving Metabolic Pathway Efficiency by Statistical Model-Based Multivariate Regulatory Metabolic Engineering.

Authors: Xu, Peng; Rizzoni, Elizabeth Anne; Sul, Se-Yeong; Stephanopoulos, Gregory

Year: 2017

Venue: ACS synthetic biology

DOI: https://doi.org/10.1021/acssynbio.6b00187

Paper Application of Global Sensitivity Analysis to Determine Goals for Design of Experiments: An Example Study on Antibody-Producing Cell Cultures

Kontoravdi, Cleo; Asprey, Steven P.; Pistikopoulos, Efstratios N. et al. · 2005 · Biotechnology Progress · DOI

Full title: Application of Global Sensitivity Analysis to Determine Goals for Design of Experiments: An Example Study on Antibody-Producing Cell Cultures

Authors: Kontoravdi, Cleo; Asprey, Steven P.; Pistikopoulos, Efstratios N.; Mantalaris, Athanasios

Year: 2005

Venue: Biotechnology Progress

DOI: https://doi.org/10.1021/bp050028k

Paper Enhancing the production of Fc fusion protein in fed-batch fermentation of Pichia pastoris by design of experiments.

Lin, Henry; Kim, Tina; Xiong, Fei et al. · 2007 · Biotechnology progress · DOI

Full title: Enhancing the production of Fc fusion protein in fed-batch fermentation of Pichia pastoris by design of experiments.

Authors: Lin, Henry; Kim, Tina; Xiong, Fei; Yang, Xiaoming

Year: 2007

Venue: Biotechnology progress

DOI: https://doi.org/10.1021/bp0603199

Paper Framework for the rapid optimization of soluble protein expression in Escherichia coli combining microscale experiments and statistical experimental design.

Islam, R S; Tisi, D; Levy, M S et al. · 2007 · Biotechnology progress · DOI

Full title: Framework for the rapid optimization of soluble protein expression in Escherichia coli combining microscale experiments and statistical experimental design.

Authors: Islam, R S; Tisi, D; Levy, M S; Lye, G J

Year: 2007

Venue: Biotechnology progress

DOI: https://doi.org/10.1021/bp070059a

Paper PCA Combined Model-Based Design of Experiments (DOE) Criteria for Differential and Algebraic System Parameter Estimation

Zhang, Yang; Edgar, Thomas F. · 2008 · Industrial & Engineering Chemistry Research · DOI

Full title: PCA Combined Model-Based Design of Experiments (DOE) Criteria for Differential and Algebraic System Parameter Estimation

Authors: Zhang, Yang; Edgar, Thomas F.

Year: 2008

Venue: Industrial & Engineering Chemistry Research

DOI: https://doi.org/10.1021/ie071206c

Paper Efficient Visual Mixture Design of Experiments using Property Clustering Techniques

Solvason, Charles C.; Chemmangattuvalappil, Nishanth G.; Eljack, Fadwa et al. · 2009 · Industrial & Engineering Chemistry Research · DOI

Full title: Efficient Visual Mixture Design of Experiments using Property Clustering Techniques

Authors: Solvason, Charles C.; Chemmangattuvalappil, Nishanth G.; Eljack, Fadwa; Eden, Mario R.

Year: 2009

Venue: Industrial & Engineering Chemistry Research

DOI: https://doi.org/10.1021/ie800877d

Paper Combinatorial discovery of reusable noncovalent supports for enzyme immobilization and nonaqueous catalysis.

Long, James; Hutcheon, Gillian A; Cooper, Andrew I · 2007 · Journal of combinatorial chemistry · DOI

Full title: Combinatorial discovery of reusable noncovalent supports for enzyme immobilization and nonaqueous catalysis.

Authors: Long, James; Hutcheon, Gillian A; Cooper, Andrew I

Year: 2007

Venue: Journal of combinatorial chemistry

DOI: https://doi.org/10.1021/cc060121g

Paper Medium optimization of transformed root cultures of Stizolobium hassjoo producing L-DOPA with response surface methodology.

Sung, L S; Huang, S Y · 2000 · Biotechnology progress · DOI

Full title: Medium optimization of transformed root cultures of Stizolobium hassjoo producing L-DOPA with response surface methodology.

Authors: Sung, L S; Huang, S Y

Year: 2000

Venue: Biotechnology progress

DOI: https://doi.org/10.1021/bp000062t

Paper Screening Design of Experiment (DOE) Applied to Supercritical Antisolvent Process

Subra, Pascale; Jestin, Patrick · 2000 · Industrial & Engineering Chemistry Research · DOI

Full title: Screening Design of Experiment (DOE) Applied to Supercritical Antisolvent Process

Authors: Subra, Pascale; Jestin, Patrick

Year: 2000

Venue: Industrial & Engineering Chemistry Research

DOI: https://doi.org/10.1021/ie990940w

Paper A Lactose-Based Kluyveromyces lactis Cell-Free Protein Synthesis System.

Shivakumar, Tejasvi; Das, Akashaditya; Bussoletti Panizo, Maria Victoria et al. · 2025 · Chem & bio engineering · DOI

Full title: A Lactose-Based Kluyveromyces lactis Cell-Free Protein Synthesis System.

Authors: Shivakumar, Tejasvi; Das, Akashaditya; Bussoletti Panizo, Maria Victoria; Storch, Marko; Thavarajah, Walter; Freemont, Paul S; Polizzi, Karen M

Year: 2025

Venue: Chem & bio engineering

DOI: https://doi.org/10.1021/cbe.5c00011

Paper Multiscale Model and Informatics-Based Optimal Design of Experiments: Application to the Catalytic Decomposition of Ammonia on Ruthenium

Prasad, Vinay; Vlachos, Dionisios G. · 2008 · Industrial & Engineering Chemistry Research · DOI

Full title: Multiscale Model and Informatics-Based Optimal Design of Experiments: Application to the Catalytic Decomposition of Ammonia on Ruthenium

Authors: Prasad, Vinay; Vlachos, Dionisios G.

Year: 2008

Venue: Industrial & Engineering Chemistry Research

DOI: https://doi.org/10.1021/ie800343s

Paper Engineering Polymer-Lipid Integrated Nanoparticles with Quantitative Design Principles for Organ-Selective mRNA Delivery.

Wang, Qin; Chen, Shanshan; Li, Gang et al. · 2026 · Journal of the American Chemical Society · DOI

Full title: Engineering Polymer-Lipid Integrated Nanoparticles with Quantitative Design Principles for Organ-Selective mRNA Delivery.

Authors: Wang, Qin; Chen, Shanshan; Li, Gang; Hou, Tailin; Yao, Tongyue; Zhou, Mo; Liu, Zhuang; Jiang, Wei; Wang, Yucai

Year: 2026

Venue: Journal of the American Chemical Society

DOI: https://doi.org/10.1021/jacs.5c22504

Paper Reactive extraction of Jatropha curcas L. seed for production of biodiesel: process optimization study.

Shuit, Siew Hoong; Lee, Keat Teong; Kamaruddin, Azlina Harun et al. · 2010 · Environmental science & technology · DOI

Full title: Reactive extraction of Jatropha curcas L. seed for production of biodiesel: process optimization study.

Authors: Shuit, Siew Hoong; Lee, Keat Teong; Kamaruddin, Azlina Harun; Yusup, Suzana

Year: 2010

Venue: Environmental science & technology

DOI: https://doi.org/10.1021/es902608v

Paper In vitro cell culture in hollow microfibers with porous structures.

Ranjan, Vivek Damodar; Zeng, Peiqin; Li, Boyuan et al. · 2020 · Biomaterials science · DOI

Full title: In vitro cell culture in hollow microfibers with porous structures.

Authors: Ranjan, Vivek Damodar; Zeng, Peiqin; Li, Boyuan; Zhang, Yilei

Year: 2020

Venue: Biomaterials science

DOI: https://doi.org/10.1039/c9bm01986c

Paper Genome Insight and factorial design to elucidate the regulation of the tryptophan-mediated IAA biosynthetic pathway in an endophyte.

Khan, Sohail; Mathur, Ashwani · 2026 · Scientific reports · DOI

Full title: Genome Insight and factorial design to elucidate the regulation of the tryptophan-mediated IAA biosynthetic pathway in an endophyte.

Authors: Khan, Sohail; Mathur, Ashwani

Year: 2026

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-026-40546-y

Paper Customized hydrogel substrates for serum-free expansion of functional hMSCs.

Le, Ngoc Nhi T; Liu, Tianran Leona; Johnston, James et al. · 2020 · Biomaterials science · DOI

Full title: Customized hydrogel substrates for serum-free expansion of functional hMSCs.

Authors: Le, Ngoc Nhi T; Liu, Tianran Leona; Johnston, James; Krutty, John D; Templeton, Kayla Marie; Harms, Victoria; Dias, Andrew; Le, Hau; Gopalan, Padma; Murphy, William L

Year: 2020

Venue: Biomaterials science

DOI: https://doi.org/10.1039/d0bm00540a

Paper Studies of particle drying using non-invasive Raman spectrometry and particle size analysis.

Hamilton, Peter; Littlejohn, David; Nordon, Alison et al. · 2011 · The Analyst · DOI

Full title: Studies of particle drying using non-invasive Raman spectrometry and particle size analysis.

Authors: Hamilton, Peter; Littlejohn, David; Nordon, Alison; Sefcik, Jan; Slavin, Paul; Dallin, Paul; Andrews, John

Year: 2011

Venue: The Analyst

DOI: https://doi.org/10.1039/c0an00893a

Paper A DoE-guided development and validation of a novel HPLC method for determining N-acetylmuramoyl-L-alanine amidase activity via p-nitroaniline quantification.

Kadziński, Leszek; Frankowska, Natalia; Babińska-Wensierska, Weronika et al. · 2025 · Analytical methods : advancing methods and applications · DOI

Full title: A DoE-guided development and validation of a novel HPLC method for determining N-acetylmuramoyl-L-alanine amidase activity via p-nitroaniline quantification.

Authors: Kadziński, Leszek; Frankowska, Natalia; Babińska-Wensierska, Weronika; Hinc, Krzysztof; Banecki, Bogdan

Year: 2025

Venue: Analytical methods : advancing methods and applications

DOI: https://doi.org/10.1039/d5ay00310e

Paper Use of the design-of-experiments approach for the development of a refolding technology for progenipoietin-1, a recombinant human cytokine fusion protein from Escherichia coli inclusion bodies.

Boyle, Denis M; Buckley, John J; Johnson, Gary V et al. · 2009 · Biotechnology and applied biochemistry · DOI

Full title: Use of the design-of-experiments approach for the development of a refolding technology for progenipoietin-1, a recombinant human cytokine fusion protein from Escherichia coli inclusion bodies.

Authors: Boyle, Denis M; Buckley, John J; Johnson, Gary V; Rathore, Anurag; Gustafson, Mark E

Year: 2009

Venue: Biotechnology and applied biochemistry

DOI: https://doi.org/10.1042/BA20080268

Paper One-Factor-at-a-Time versus Designed Experiments

Czitrom, Verónica · 1999 · The American Statistician · DOI

Full title: One-Factor-at-a-Time versus Designed Experiments

Authors: Czitrom, Verónica

Year: 1999

Venue: The American Statistician

DOI: https://doi.org/10.1080/00031305.1999.10474445

Paper Design of experiments (DoE) to develop and to optimize extraction of psychoactive substances.

Tang, Tiantian; Chen, Wanyi; Li, Lixian et al. · 2023 · Analytical methods : advancing methods and applications · DOI

Full title: Design of experiments (DoE) to develop and to optimize extraction of psychoactive substances.

Authors: Tang, Tiantian; Chen, Wanyi; Li, Lixian; Cao, Shurui

Year: 2023

Venue: Analytical methods : advancing methods and applications

DOI: https://doi.org/10.1039/d3ay00059a

Paper Computer-Aided Design of Experiments—Some Practical Experiences

Snee, Ronald D. · 1985 · Journal of Quality Technology · DOI

Full title: Computer-Aided Design of Experiments—Some Practical Experiences

Authors: Snee, Ronald D.

Year: 1985

Venue: Journal of Quality Technology

DOI: https://doi.org/10.1080/00224065.1985.11978972

Paper Analysis of Designed Experiments with Complex Aliasing

Hamada, Michael S.; Wu, Changbao · 1992 · Journal of Quality Technology · DOI

Full title: Analysis of Designed Experiments with Complex Aliasing

Authors: Hamada, Michael S.; Wu, Changbao

Year: 1992

Venue: Journal of Quality Technology

DOI: https://doi.org/10.1080/00224065.1992.11979383

Paper Computer Experiments for Quality Control by Parameter Design

Welch, William J.; Yu, Tat-Kwan; Kang, Sung Mo et al. · 1990 · Journal of Quality Technology · DOI

Full title: Computer Experiments for Quality Control by Parameter Design

Authors: Welch, William J.; Yu, Tat-Kwan; Kang, Sung Mo; Sacks, Jerome

Year: 1990

Venue: Journal of Quality Technology

DOI: https://doi.org/10.1080/00224065.1990.11979201

Paper Constrained Maximisation and the Design of Experiments

Atkinson, Anthony C. · 1969 · Technometrics · DOI

Full title: Constrained Maximisation and the Design of Experiments

Authors: Atkinson, Anthony C.

Year: 1969

Venue: Technometrics

DOI: https://doi.org/10.1080/00401706.1969.10490717

Paper The Design of Experiments for Parameter Estimation

Atkinson, Anthony C.; Hunter, William G. · 1968 · Technometrics · DOI

Full title: The Design of Experiments for Parameter Estimation

Authors: Atkinson, Anthony C.; Hunter, William G.

Year: 1968

Venue: Technometrics

DOI: https://doi.org/10.1080/00401706.1968.10490560

Paper Design of Experiments with Two- and Four-Level Factors

Ankenman, Bruce E. · 1999 · Journal of Quality Technology · DOI

Full title: Design of Experiments with Two- and Four-Level Factors

Authors: Ankenman, Bruce E.

Year: 1999

Venue: Journal of Quality Technology

DOI: https://doi.org/10.1080/00224065.1999.11979943

Paper Computer Aided Design of Experiments

Kennard, R. W.; Stone, L. A. · 1969 · Technometrics · DOI

Full title: Computer Aided Design of Experiments

Authors: Kennard, R. W.; Stone, L. A.

Year: 1969

Venue: Technometrics

DOI: https://doi.org/10.1080/00401706.1969.10490666

Paper Bayesian Design and Analysis of Computer Experiments: Use of Derivatives in Surface Prediction

Morris, Max D.; Mitchell, Toby J.; Ylvisaker, Donald · 1993 · Technometrics · DOI

Full title: Bayesian Design and Analysis of Computer Experiments: Use of Derivatives in Surface Prediction

Authors: Morris, Max D.; Mitchell, Toby J.; Ylvisaker, Donald

Year: 1993

Venue: Technometrics

DOI: https://doi.org/10.1080/00401706.1993.10485320

Paper Extreme Vertices Design of Mixture Experiments

Mclean, Robert A.; Anderson, Virgil L. · 1966 · Technometrics · DOI

Full title: Extreme Vertices Design of Mixture Experiments

Authors: Mclean, Robert A.; Anderson, Virgil L.

Year: 1966

Venue: Technometrics

DOI: https://doi.org/10.1080/00401706.1966.10490377

Paper Computer-Aided Design of Experiments for Response Estimation

Welch, William J. · 1984 · Technometrics · DOI

Full title: Computer-Aided Design of Experiments for Response Estimation

Authors: Welch, William J.

Year: 1984

Venue: Technometrics

DOI: https://doi.org/10.1080/00401706.1984.10487958

Paper Bayesian Computation Using Design of Experiments-Based Interpolation Technique

Joseph, V. Roshan · 2012 · Technometrics · DOI

Full title: Bayesian Computation Using Design of Experiments-Based Interpolation Technique

Authors: Joseph, V. Roshan

Year: 2012

Venue: Technometrics

DOI: https://doi.org/10.1080/00401706.2012.680399

Paper Bayesian Design of Experiments Using Approximate Coordinate Exchange

Overstall, Antony M.; Woods, David C. · 2016 · Technometrics · DOI

Full title: Bayesian Design of Experiments Using Approximate Coordinate Exchange

Authors: Overstall, Antony M.; Woods, David C.

Year: 2016

Venue: Technometrics

DOI: https://doi.org/10.1080/00401706.2016.1251495

Paper Bayesian Prediction of Deterministic Functions, with Applications to the Design and Analysis of Computer Experiments

Currin, Carla; Mitchell, Toby J.; Morris, Max D. et al. · 1991 · Journal of the American Statistical Association · DOI

Full title: Bayesian Prediction of Deterministic Functions, with Applications to the Design and Analysis of Computer Experiments

Authors: Currin, Carla; Mitchell, Toby J.; Morris, Max D.; Ylvisaker, Don

Year: 1991

Venue: Journal of the American Statistical Association

DOI: https://doi.org/10.1080/01621459.1991.10475138

Paper Adaptive Design of Experiments for Conservative Estimation of Excursion Sets

Azzimonti, Dario; Ginsbourger, David; Chevalier, Clément et al. · 2017 · HAL (Le Centre pour la Communication Scientifique Directe) · DOI

Full title: Adaptive Design of Experiments for Conservative Estimation of Excursion Sets

Authors: Azzimonti, Dario; Ginsbourger, David; Chevalier, Clément; Bect, Julien; Richet, Yann

Year: 2017

Venue: HAL (Le Centre pour la Communication Scientifique Directe)

DOI: https://doi.org/10.1080/00401706.2019.1693427

Paper Implementation of design of experiments approach for the micronization of a drug with a high brittle-ductile transition particle diameter.

Yazdi, Ashkan K; Smyth, Hugh D C · 2017 · Drug development and industrial pharmacy · DOI

Full title: Implementation of design of experiments approach for the micronization of a drug with a high brittle-ductile transition particle diameter.

Authors: Yazdi, Ashkan K; Smyth, Hugh D C

Year: 2017

Venue: Drug development and industrial pharmacy

DOI: https://doi.org/10.1080/03639045.2016.1253727

Paper Systematic development of design of experiments (DoE) optimised self-microemulsifying drug delivery system of Zotepine.

Dalvadi, Hitesh; Patel, Nikita; Parmar, Komal · 2017 · Journal of microencapsulation · DOI

Full title: Systematic development of design of experiments (DoE) optimised self-microemulsifying drug delivery system of Zotepine.

Authors: Dalvadi, Hitesh; Patel, Nikita; Parmar, Komal

Year: 2017

Venue: Journal of microencapsulation

DOI: https://doi.org/10.1080/02652048.2017.1324920

Paper Fabrication, optimisation and in vitro evaluation of docetaxel and curcumin Co-loaded nanostructured lipid carriers for improved antitumor activity against non-small cell lung carcinoma.

Rawal, Shruti; Patel, Bhoomika; Patel, Mayur M · 2020 · Journal of microencapsulation · DOI

Full title: Fabrication, optimisation and in vitro evaluation of docetaxel and curcumin Co-loaded nanostructured lipid carriers for improved antitumor activity against non-small cell lung carcinoma.

Authors: Rawal, Shruti; Patel, Bhoomika; Patel, Mayur M

Year: 2020

Venue: Journal of microencapsulation

DOI: https://doi.org/10.1080/02652048.2020.1823498

Paper Spray-drying process optimization for manufacture of drug-cyclodextrin complex powder using design of experiments.

Nekkanti, Vijaykumar; Muniyappan, Thilekkumar; Karatgi, Pradeep et al. · 2009 · Drug development and industrial pharmacy · DOI

Full title: Spray-drying process optimization for manufacture of drug-cyclodextrin complex powder using design of experiments.

Authors: Nekkanti, Vijaykumar; Muniyappan, Thilekkumar; Karatgi, Pradeep; Hari, Molleti Sri; Marella, Seshasai; Pillai, Raviraj

Year: 2009

Venue: Drug development and industrial pharmacy

DOI: https://doi.org/10.1080/03639040902882264

Paper A step forward towards the development of stable freeze-dried liposomes: a quality by design approach (QbD).

Sylvester, Bianca; Porfire, Alina; Achim, Marcela et al. · 2018 · Drug development and industrial pharmacy · DOI

Full title: A step forward towards the development of stable freeze-dried liposomes: a quality by design approach (QbD).

Authors: Sylvester, Bianca; Porfire, Alina; Achim, Marcela; Rus, Lucia; Tomuţă, Ioan

Year: 2018

Venue: Drug development and industrial pharmacy

DOI: https://doi.org/10.1080/03639045.2017.1395457

Paper Development of separation technology for the removal of radium-223 from targeted thorium conjugate formulations. Part II: purification of targeted thorium conjugates on cation exchange columns.

Frenvik, Janne Olsen; Dyrstad, Knut; Kristensen, Solveig et al. · 2017 · Drug development and industrial pharmacy · DOI

Full title: Development of separation technology for the removal of radium-223 from targeted thorium conjugate formulations. Part II: purification of targeted thorium conjugates on cation exchange columns.

Authors: Frenvik, Janne Olsen; Dyrstad, Knut; Kristensen, Solveig; Ryan, Olav B

Year: 2017

Venue: Drug development and industrial pharmacy

DOI: https://doi.org/10.1080/03639045.2017.1318906

Paper Development of rapidly dissolving pellets within the Quality by Design approach.

Karatzas, A A; Politis, S N; Rekkas, D M · 2017 · Drug development and industrial pharmacy · DOI

Full title: Development of rapidly dissolving pellets within the Quality by Design approach.

Authors: Karatzas, A A; Politis, S N; Rekkas, D M

Year: 2017

Venue: Drug development and industrial pharmacy

DOI: https://doi.org/10.1080/03639045.2016.1220576

Paper Box-Behnken design directed optimization for sensitivity assessment of anti-platelet drugs.

Nalawade, Vivek; Vora, Amisha · 2019 · Drug development and industrial pharmacy · DOI

Full title: Box-Behnken design directed optimization for sensitivity assessment of anti-platelet drugs.

Authors: Nalawade, Vivek; Vora, Amisha

Year: 2019

Venue: Drug development and industrial pharmacy

DOI: https://doi.org/10.1080/03639045.2019.1634092

Paper Optimization of gliclazide loaded alginate-gelatin beads employing central composite design.

Elsayed, Ebtesam W; El-Ashmawy, Ahmed A; Mursi, Nadia M et al. · 2019 · Drug development and industrial pharmacy · DOI

Full title: Optimization of gliclazide loaded alginate-gelatin beads employing central composite design.

Authors: Elsayed, Ebtesam W; El-Ashmawy, Ahmed A; Mursi, Nadia M; Emara, Laila H

Year: 2019

Venue: Drug development and industrial pharmacy

DOI: https://doi.org/10.1080/03639045.2019.1689992

Paper Formulation and optimization for DPP-4 inhibitor nanomicelles using response surface methodology.

Sharma, Deepika; Bhargava, Samir; Kumar, Bhavna · 2020 · Drug development and industrial pharmacy · DOI

Full title: Formulation and optimization for DPP-4 inhibitor nanomicelles using response surface methodology.

Authors: Sharma, Deepika; Bhargava, Samir; Kumar, Bhavna

Year: 2020

Venue: Drug development and industrial pharmacy

DOI: https://doi.org/10.1080/03639045.2019.1701003

Paper Application of experimental designs and response surface methods in screening and optimization of reverse micellar extraction.

Sy Mohamad, Sharifah Fathiyah; Mohd Said, Farhan; Abdul Munaim, Mimi Sakinah et al. · 2020 · Critical reviews in biotechnology · DOI

Full title: Application of experimental designs and response surface methods in screening and optimization of reverse micellar extraction.

Authors: Sy Mohamad, Sharifah Fathiyah; Mohd Said, Farhan; Abdul Munaim, Mimi Sakinah; Mohamad, Shahril; Azizi Wan Sulaiman, Wan Mohd

Year: 2020

Venue: Critical reviews in biotechnology

DOI: https://doi.org/10.1080/07388551.2020.1712321

Paper Development of effective AmB/AmB-αCD complex double loaded liposomes using a factorial design for systemic fungal infection treatment.

Mutlu-Agardan, N Basaran; Yilmaz, Sukran; Kaynak Onurdag, Fatma et al. · 2021 · Journal of liposome research · DOI

Full title: Development of effective AmB/AmB-αCD complex double loaded liposomes using a factorial design for systemic fungal infection treatment.

Authors: Mutlu-Agardan, N Basaran; Yilmaz, Sukran; Kaynak Onurdag, Fatma; Celebi, Nevin

Year: 2021

Venue: Journal of liposome research

DOI: https://doi.org/10.1080/08982104.2020.1755980

Paper Application of Design of Experiments and Multilayer Perceptron Neural Network in Optimization of the Spray-Drying Process

Mihajlovic, Tijana; Ibrić, Svetlana; Mladenović, Aleksandar · 2011 · Drying Technology · DOI

Full title: Application of Design of Experiments and Multilayer Perceptron Neural Network in Optimization of the Spray-Drying Process

Authors: Mihajlovic, Tijana; Ibrić, Svetlana; Mladenović, Aleksandar

Year: 2011

Venue: Drying Technology

DOI: https://doi.org/10.1080/07373937.2011.592960

Paper Enhancing quality-by-design through weighted goal programming: a case study on formulation of ultradeformable liposomes.

Valverde Cabeza, Sonia; González-R, Pedro Luis; González-Rodríguez, María Luisa · 2025 · Drug development and industrial pharmacy · DOI

Full title: Enhancing quality-by-design through weighted goal programming: a case study on formulation of ultradeformable liposomes.

Authors: Valverde Cabeza, Sonia; González-R, Pedro Luis; González-Rodríguez, María Luisa

Year: 2025

Venue: Drug development and industrial pharmacy

DOI: https://doi.org/10.1080/03639045.2025.2470397

Paper Optimally controlled morphology and physico-mechanical properties of inclusion complex loaded electrospun polyvinyl alcohol based nanofibrous mats for therapeutic applications.

Sharma, Deepika; Satapathy, Bhabani K · 2021 · Journal of biomaterials science. Polymer edition · DOI

Full title: Optimally controlled morphology and physico-mechanical properties of inclusion complex loaded electrospun polyvinyl alcohol based nanofibrous mats for therapeutic applications.

Authors: Sharma, Deepika; Satapathy, Bhabani K

Year: 2021

Venue: Journal of biomaterials science. Polymer edition

DOI: https://doi.org/10.1080/09205063.2021.1909414

Paper The immobilized Alcaligenes faecalis strain WT14 for removing high strength nitrate and reducing nitrite accumulation

Junli Chen; Shu-nan Zhang; Feng Liu et al. · 2020 · Environmental technology · DOI

Full title: The immobilized Alcaligenes faecalis strain WT14 for removing high strength nitrate and reducing nitrite accumulation

Authors: Junli Chen; Shu-nan Zhang; Feng Liu; Pei Luo; R. Xiao; Miao-miao Zhang; Jinshui Wu

Year: 2020

Venue: Environmental technology

DOI: https://doi.org/10.1080/09593330.2020.1780476

Paper Optimization of biotransformation process for the synthesis of pyrazine-2-carboxylic acid hydrazide using acyltransferase activity of Bacillus smithii IITR6b2 in batch and fed-batch mode

Swasti Lavania; Bijan Choudhury · 2024 · Biocatalysis and Biotransformation · DOI

Full title: Optimization of biotransformation process for the synthesis of pyrazine-2-carboxylic acid hydrazide using acyltransferase activity of Bacillus smithii IITR6b2 in batch and fed-batch mode

Authors: Swasti Lavania; Bijan Choudhury

Year: 2024

Venue: Biocatalysis and Biotransformation

DOI: https://doi.org/10.1080/10242422.2024.2368062

Paper The use of dimensional analysis to augment design of experiments for optimization and robustification

Lacey, Damien; Steele, Clint · 2006 · Journal of Engineering Design · DOI

Full title: The use of dimensional analysis to augment design of experiments for optimization and robustification

Authors: Lacey, Damien; Steele, Clint

Year: 2006

Venue: Journal of Engineering Design

DOI: https://doi.org/10.1080/09544820500275594

Paper Optimization of novel and greener approach for the coproduction of uricase and alkaline protease in Bacillus licheniformis by Box-Behnken model.

Pawar, Shweta V; Rathod, Virendra K · 2018 · Preparative biochemistry & biotechnology · DOI

Full title: Optimization of novel and greener approach for the coproduction of uricase and alkaline protease in Bacillus licheniformis by Box-Behnken model.

Authors: Pawar, Shweta V; Rathod, Virendra K

Year: 2018

Venue: Preparative biochemistry & biotechnology

DOI: https://doi.org/10.1080/10826068.2017.1381623

Paper Artificial Intelligence in HPLC Method Development: A Critical Review of Technological Integration, Limitations, and Future Directions.

Alves, Erica; Gurupadayya, B M; Prabhakaran, Prabitha · 2025 · Critical reviews in analytical chemistry · DOI

Full title: Artificial Intelligence in HPLC Method Development: A Critical Review of Technological Integration, Limitations, and Future Directions.

Authors: Alves, Erica; Gurupadayya, B M; Prabhakaran, Prabitha

Year: 2025

Venue: Critical reviews in analytical chemistry

DOI: https://doi.org/10.1080/10408347.2025.2575352

Paper Optimization of tetanus toxoid ammonium sulfate precipitation process using response surface methodology.

Brgles, Marija; Prebeg, Pero; Kurtović, Tihana et al. · 2016 · Preparative biochemistry & biotechnology · DOI

Full title: Optimization of tetanus toxoid ammonium sulfate precipitation process using response surface methodology.

Authors: Brgles, Marija; Prebeg, Pero; Kurtović, Tihana; Ranić, Jelena; Marchetti-Deschmann, Martina; Allmaier, Günter; Halassy, Beata

Year: 2016

Venue: Preparative biochemistry & biotechnology

DOI: https://doi.org/10.1080/10826068.2015.1135452

Paper Design of Experiments: Concept and Applications of Plackett Burman Design

Vanaja, K.; Rani, Reetu · 2007 · Clinical Research and Regulatory Affairs · DOI

Full title: Design of Experiments: Concept and Applications of Plackett Burman Design

Authors: Vanaja, K.; Rani, Reetu

Year: 2007

Venue: Clinical Research and Regulatory Affairs

DOI: https://doi.org/10.1080/10601330701220520

Paper Medium optimization of antifungal activity production by Bacillus amyloliquefaciens using statistical experimental design.

Mezghanni, Héla; Khedher, Saoussen Ben; Tounsi, Slim et al. · 2012 · Preparative biochemistry & biotechnology · DOI

Full title: Medium optimization of antifungal activity production by Bacillus amyloliquefaciens using statistical experimental design.

Authors: Mezghanni, Héla; Khedher, Saoussen Ben; Tounsi, Slim; Zouari, Nabil

Year: 2012

Venue: Preparative biochemistry & biotechnology

DOI: https://doi.org/10.1080/10826068.2011.614989

Paper Optimum Design of Experiments for Enzyme Inhibition Kinetic Models

Bogacka, Barbara; Patan, Maciej; Johnson, Patrick et al. · 2011 · Journal of Biopharmaceutical Statistics · DOI

Full title: Optimum Design of Experiments for Enzyme Inhibition Kinetic Models

Authors: Bogacka, Barbara; Patan, Maciej; Johnson, Patrick; Youdim, Kuresh; Atkinson, Anthony C.

Year: 2011

Venue: Journal of Biopharmaceutical Statistics

DOI: https://doi.org/10.1080/10543406.2010.489979

Paper High-throughput clone screening and upstream process optimization for recombinant therapeutic peptide expression: biosimilar teriparatide (PTH-34): a case study.

Ughade, Santosh; Nandanwar, Mrunali; Yoge, Gauri et al. · 2026 · Preparative biochemistry & biotechnology · DOI

Full title: High-throughput clone screening and upstream process optimization for recombinant therapeutic peptide expression: biosimilar teriparatide (PTH-34): a case study.

Authors: Ughade, Santosh; Nandanwar, Mrunali; Yoge, Gauri; Vidhate, Ravindra; Bhambure, Rahul

Year: 2026

Venue: Preparative biochemistry & biotechnology

DOI: https://doi.org/10.1080/10826068.2026.2635143

Paper Bioprocess optimization of L-glutaminase production by a novel Klebsiella pneumoniae strain SCPRC using response surface methodology.

Chacko, Smitha; Simon, Emmanuel; Sebastian, Denoj · 2026 · Preparative biochemistry & biotechnology · DOI

Full title: Bioprocess optimization of L-glutaminase production by a novel Klebsiella pneumoniae strain SCPRC using response surface methodology.

Authors: Chacko, Smitha; Simon, Emmanuel; Sebastian, Denoj

Year: 2026

Venue: Preparative biochemistry & biotechnology

DOI: https://doi.org/10.1080/10826068.2025.2607434

Paper Isolation, identification and optimization of enhanced production of laccase from Galactomyces geotrichum under solid-state fermentation.

Pourkhanali, Khadijeh; Khayati, Gholam; Mizani, Farhang et al. · 2021 · Preparative biochemistry & biotechnology · DOI

Full title: Isolation, identification and optimization of enhanced production of laccase from Galactomyces geotrichum under solid-state fermentation.

Authors: Pourkhanali, Khadijeh; Khayati, Gholam; Mizani, Farhang; Raouf, Fereshteh

Year: 2021

Venue: Preparative biochemistry & biotechnology

DOI: https://doi.org/10.1080/10826068.2020.1848867

Paper The multiple-response modeling of heat-assisted, microwave-assisted and subcritical water extraction on selected phenolics from traditional plant species Teucrium montanum

Ana Mandura Jarić; Danijela Šeremet; Aleksandra Vojvodić Cebin et al. · 2021 · Preparative Biochemistry & Biotechnology · DOI

Full title: The multiple-response modeling of heat-assisted, microwave-assisted and subcritical water extraction on selected phenolics from traditional plant species Teucrium montanum

Authors: Ana Mandura Jarić; Danijela Šeremet; Aleksandra Vojvodić Cebin; S. Jokić; D. Komes

Year: 2021

Venue: Preparative Biochemistry & Biotechnology

DOI: https://doi.org/10.1080/10826068.2021.1998111

Paper Formaldehyde degradation by Ralstonia eutropha in an immobilized cell bioreactor.

Habibi, Alireza; Vahabzadeh, Farzaneh · 2013 · Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering · DOI

Full title: Formaldehyde degradation by Ralstonia eutropha in an immobilized cell bioreactor.

Authors: Habibi, Alireza; Vahabzadeh, Farzaneh

Year: 2013

Venue: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering

DOI: https://doi.org/10.1080/10934529.2013.797304

Paper Development of a semidefined growth medium for Pedobacter cryoconitis BG5 using statistical experimental design.

Ong, Magdalena; Ongkudon, Clarence M; Wong, Clemente Michael Vui Ling · 2016 · Preparative biochemistry & biotechnology · DOI

Full title: Development of a semidefined growth medium for Pedobacter cryoconitis BG5 using statistical experimental design.

Authors: Ong, Magdalena; Ongkudon, Clarence M; Wong, Clemente Michael Vui Ling

Year: 2016

Venue: Preparative biochemistry & biotechnology

DOI: https://doi.org/10.1080/10826068.2015.1135447

Paper Discriminating chemometric analysis to study chemical variation between different altitude Bergenia ciliata (Haw.) Sternb. rhizomes following AQbD approach for high recovery of bergenin.

Dahiya, Jyoti; Mangal, Anupam K; Bolleddu, Rajesh et al. · 2026 · Natural product research · DOI

Full title: Discriminating chemometric analysis to study chemical variation between different altitude Bergenia ciliata (Haw.) Sternb. rhizomes following AQbD approach for high recovery of bergenin.

Authors: Dahiya, Jyoti; Mangal, Anupam K; Bolleddu, Rajesh; Abdullah, Salik; Ahmed, Ijaz; Arya, Deepshikha; Raturi, Manoj; Singh, Hardeep; Sen, Animesh; Babu, Gajji

Year: 2026

Venue: Natural product research

DOI: https://doi.org/10.1080/14786419.2026.2613280

Paper Recovery of anthocyanins from sour cherry (Prunus cerasus L.) peels via microwave assisted extraction: monitoring the storage stability.

Kurtulbaş Şahin, Ebru; Bilgin, Mehmet; Şahin, Selin · 2021 · Preparative biochemistry & biotechnology · DOI

Full title: Recovery of anthocyanins from sour cherry (Prunus cerasus L.) peels via microwave assisted extraction: monitoring the storage stability.

Authors: Kurtulbaş Şahin, Ebru; Bilgin, Mehmet; Şahin, Selin

Year: 2021

Venue: Preparative biochemistry & biotechnology

DOI: https://doi.org/10.1080/10826068.2020.1852418

Paper Selective removal of closely related clipped protein impurities using poly(ethylenimine)- grafted anion-exchange chromatography resin.

Sivanathan, Ganesh T; Mallubhotla, Hanuman; Suggala, Satyanarayana V · 2019 · Preparative biochemistry & biotechnology · DOI

Full title: Selective removal of closely related clipped protein impurities using poly(ethylenimine)- grafted anion-exchange chromatography resin.

Authors: Sivanathan, Ganesh T; Mallubhotla, Hanuman; Suggala, Satyanarayana V

Year: 2019

Venue: Preparative biochemistry & biotechnology

DOI: https://doi.org/10.1080/10826068.2019.1650373

Paper Optimization of medium composition for two-step fermentation of vitamin C based on artificial neural network–genetic algorithm techniques

Yu Yang; M. Gao; Xiaodan Yu et al. · 2015 · DOI

Full title: Optimization of medium composition for two-step fermentation of vitamin C based on artificial neural network–genetic algorithm techniques

Authors: Yu Yang; M. Gao; Xiaodan Yu; Yun-he Zhang; Shuxia Lyu

Year: 2015

DOI: https://doi.org/10.1080/13102818.2015.1063970

Paper Optimization of non-detergent treatment for enveloped virus inactivation using the Taguchi design of experimental methodology (DOE).

Khosravi, Roya; Hosseini, Seyed Nezamedin; Javidanbardan, Amin et al. · 2019 · Preparative biochemistry & biotechnology · DOI

Full title: Optimization of non-detergent treatment for enveloped virus inactivation using the Taguchi design of experimental methodology (DOE).

Authors: Khosravi, Roya; Hosseini, Seyed Nezamedin; Javidanbardan, Amin; Khatami, Maryam; Kaghazian, Hooman; Mousavi Nasab, Seyed Dawood

Year: 2019

Venue: Preparative biochemistry & biotechnology

DOI: https://doi.org/10.1080/10826068.2019.1599398

Paper Design of experiments for the optimization of sample preparation for bottom-up targeted protein LC-MS/MS workflows.

Szarka, Szabolcs; Thorsteinsdottir, Margret; Wheller, Robert · 2025 · Bioanalysis · DOI

Full title: Design of experiments for the optimization of sample preparation for bottom-up targeted protein LC-MS/MS workflows.

Authors: Szarka, Szabolcs; Thorsteinsdottir, Margret; Wheller, Robert

Year: 2025

Venue: Bioanalysis

DOI: https://doi.org/10.1080/17576180.2025.2515004

Paper Complexities of clinical assay development and optimization prior to first-in-man immunization trials - a description of immunogenicity assay development for the testing of samples from a phase 1 Alzheimer's vaccine trial.

Hammond, Olivia; Reynolds, James; Rubinstein, Leonard J et al. · 2008 · Journal of immunoassay & immunochemistry · DOI

Full title: Complexities of clinical assay development and optimization prior to first-in-man immunization trials - a description of immunogenicity assay development for the testing of samples from a phase 1 Alzheimer's vaccine trial.

Authors: Hammond, Olivia; Reynolds, James; Rubinstein, Leonard J; Sikkema, Daniel; Marchese, Rocio D

Year: 2008

Venue: Journal of immunoassay & immunochemistry

DOI: https://doi.org/10.1080/15321810802329518

Paper Comprehensive manipulation of glycosylation profiles across development scales.

Loebrich, Sven; Clark, Elisa; Ladd, Kristina et al. · 2019 · mAbs · DOI

Full title: Comprehensive manipulation of glycosylation profiles across development scales.

Authors: Loebrich, Sven; Clark, Elisa; Ladd, Kristina; Takahashi, Stefani; Brousseau, Anna; Kitchener, Seth; Herbst, Robert; Ryll, Thomas

Year: 2019

Venue: mAbs

DOI: https://doi.org/10.1080/19420862.2018.1527665

Paper Box–Behnken design for the optimization of the removal of Cr(VI) in soil leachate using nZVI/Ni bimetallic particles

Siying He; Fang Zhu; Luwei Li et al. · 2018 · Soil & sediment contamination · DOI

Full title: Box–Behnken design for the optimization of the removal of Cr(VI) in soil leachate using nZVI/Ni bimetallic particles

Authors: Siying He; Fang Zhu; Luwei Li; Wentao Ren

Year: 2018

Venue: Soil & sediment contamination

DOI: https://doi.org/10.1080/15320383.2018.1502744

Paper Factors influencing preclinical in vivo evaluation of mumps vaccine strain immunogenicity.

Halassy, B; Kurtović, T; Brgles, M et al. · 2015 · Human vaccines & immunotherapeutics · DOI

Full title: Factors influencing preclinical in vivo evaluation of mumps vaccine strain immunogenicity.

Authors: Halassy, B; Kurtović, T; Brgles, M; Lang Balija, M; Forčić, D

Year: 2015

Venue: Human vaccines & immunotherapeutics

DOI: https://doi.org/10.1080/21645515.2015.1062191

Paper Preparation and Optimization of Leuprolide Acetate Nanoparticles Using Response Surface Methodology: In Vitro and Ex Vivo Evaluation

T. Pandya; A. Dharamsi · 2022 · Assay and drug development technologies · DOI

Full title: Preparation and Optimization of Leuprolide Acetate Nanoparticles Using Response Surface Methodology: In Vitro and Ex Vivo Evaluation

Authors: T. Pandya; A. Dharamsi

Year: 2022

Venue: Assay and drug development technologies

DOI: https://doi.org/10.1089/adt.2022.051

Paper Design of experiments approach to developing a robust ink for bioprinting.

Hegab, Rachel; Van Volkenburg, Tessa; Ohiri, Korine et al. · 2022 · Biomedical physics & engineering express · DOI

Full title: Design of experiments approach to developing a robust ink for bioprinting.

Authors: Hegab, Rachel; Van Volkenburg, Tessa; Ohiri, Korine; Sebeck, Natalie; Bessling, Seneca; Theodore, Mellisa; Rossick, Katelyn; Pellicore, Matthew; Benkoski, Jason; Patrone, Julia

Year: 2022

Venue: Biomedical physics & engineering express

DOI: https://doi.org/10.1088/2057-1976/ac5de1

Paper Optimization of a chondrogenic medium through the use of factorial design of experiments.

Enochson, Lars; Brittberg, Mats; Lindahl, Anders · 2012 · BioResearch open access · DOI

Full title: Optimization of a chondrogenic medium through the use of factorial design of experiments.

Authors: Enochson, Lars; Brittberg, Mats; Lindahl, Anders

Year: 2012

Venue: BioResearch open access

DOI: https://doi.org/10.1089/biores.2012.0277

Paper Characterization of lentiviral vector production using microwell suspension cultures of HEK293T-derived producer cells.

Guy, Heather M; McCloskey, Laura; Lye, Gary J et al. · 2013 · Human gene therapy methods · DOI

Full title: Characterization of lentiviral vector production using microwell suspension cultures of HEK293T-derived producer cells.

Authors: Guy, Heather M; McCloskey, Laura; Lye, Gary J; Mitrophanous, Kyriacos A; Mukhopadhyay, Tarit K

Year: 2013

Venue: Human gene therapy methods

DOI: https://doi.org/10.1089/hgtb.2012.200

Paper A fast and simple approach to optimize the unit operation high pressure homogenization - a case study for a soluble therapeutic protein in E. coli.

Pekarsky, Alexander; Spadiut, Oliver; Rajamanickam, Vignesh et al. · 2019 · Preparative biochemistry & biotechnology · DOI

Full title: A fast and simple approach to optimize the unit operation high pressure homogenization - a case study for a soluble therapeutic protein in E. coli.

Authors: Pekarsky, Alexander; Spadiut, Oliver; Rajamanickam, Vignesh; Wurm, David J

Year: 2019

Venue: Preparative biochemistry & biotechnology

DOI: https://doi.org/10.1080/10826068.2018.1536988

Paper Characterization and optimization of cell seeding in scaffolds by factorial design: quality by design approach for skeletal tissue engineering.

Chen, Yantian; Bloemen, Veerle; Impens, Saartje et al. · 2011 · Tissue engineering. Part C, Methods · DOI

Full title: Characterization and optimization of cell seeding in scaffolds by factorial design: quality by design approach for skeletal tissue engineering.

Authors: Chen, Yantian; Bloemen, Veerle; Impens, Saartje; Moesen, Maarten; Luyten, Frank P; Schrooten, Jan

Year: 2011

Venue: Tissue engineering. Part C, Methods

DOI: https://doi.org/10.1089/ten.tec.2011.0092

Paper The use of prior distributions in the design of experiments for parameter estimation in non-linear situations.

Draper, Norman R.; Hunter, William G. · 1967 · PubMed · DOI

Full title: The use of prior distributions in the design of experiments for parameter estimation in non-linear situations.

Authors: Draper, Norman R.; Hunter, William G.

Year: 1967

Venue: PubMed

DOI: https://doi.org/10.1093/biomet/54.3-4.662

Paper Robust freeze-drying process re-design of a legacy product based on risk analysis and design of experiments.

Clua-Palau, Gloria; Jo, Enric; Nikolic, Sasha et al. · 2020 · Drug development and industrial pharmacy · DOI

Full title: Robust freeze-drying process re-design of a legacy product based on risk analysis and design of experiments.

Authors: Clua-Palau, Gloria; Jo, Enric; Nikolic, Sasha; Coello, Jordi; Maspoch, Santiago

Year: 2020

Venue: Drug development and industrial pharmacy

DOI: https://doi.org/10.1080/03639045.2020.1842438

Paper A mean squared error criterion for the design of experiments

Welch, William J. · 1983 · Biometrika · DOI

Full title: A mean squared error criterion for the design of experiments

Authors: Welch, William J.

Year: 1983

Venue: Biometrika

DOI: https://doi.org/10.1093/biomet/70.1.205

Paper Green and Sustainable Analytical Chemistry-Driven Chromatographic Method Development for Stability Study of Apixaban Using Box-Behnken Design and Principal Component Analysis.

Prajapati, Pintu; Rajpurohit, Pooja; Pulusu, Veera Shakar et al. · 2024 · Journal of chromatographic science · DOI

Full title: Green and Sustainable Analytical Chemistry-Driven Chromatographic Method Development for Stability Study of Apixaban Using Box-Behnken Design and Principal Component Analysis.

Authors: Prajapati, Pintu; Rajpurohit, Pooja; Pulusu, Veera Shakar; Shah, Shailesh

Year: 2024

Venue: Journal of chromatographic science

DOI: https://doi.org/10.1093/chromsci/bmad033

Paper Chromatographic analysis of olopatadine in hydrophilic interaction liquid chromatography.

Maksić, Jelena; Jovanović, Marko; Rakić, Tijana et al. · 2015 · Journal of chromatographic science · DOI

Full title: Chromatographic analysis of olopatadine in hydrophilic interaction liquid chromatography.

Authors: Maksić, Jelena; Jovanović, Marko; Rakić, Tijana; Popović, Igor; Ivanović, Darko; Jančić-Stojanović, Biljana

Year: 2015

Venue: Journal of chromatographic science

DOI: https://doi.org/10.1093/chromsci/bmu102

Paper Chemometry and Green Chemistry-Based Chromatographic Analysis of Azilsartan Medoxomil, Cilnidipine and Chlorthalidone in Human Plasma Using Analytical Quality by Design Approach.

Prajapati, Pintu; Shahi, Abhinandan; Acharya, Aneri et al. · 2024 · Journal of chromatographic science · DOI

Full title: Chemometry and Green Chemistry-Based Chromatographic Analysis of Azilsartan Medoxomil, Cilnidipine and Chlorthalidone in Human Plasma Using Analytical Quality by Design Approach.

Authors: Prajapati, Pintu; Shahi, Abhinandan; Acharya, Aneri; Shah, Shailesh

Year: 2024

Venue: Journal of chromatographic science

DOI: https://doi.org/10.1093/chromsci/bmac068

Paper Application of Quality Risk Assessment and DoE-Based Enhanced Analytical Quality by Design Approach to Development of Chromatography Method for Estimation of Combined Pharmaceutical Dosage Form of Five Drugs.

Prajapati, Pintu B; Jayswal, Kajal; Shah, Shailesh A · 2021 · Journal of chromatographic science · DOI

Full title: Application of Quality Risk Assessment and DoE-Based Enhanced Analytical Quality by Design Approach to Development of Chromatography Method for Estimation of Combined Pharmaceutical Dosage Form of Five Drugs.

Authors: Prajapati, Pintu B; Jayswal, Kajal; Shah, Shailesh A

Year: 2021

Venue: Journal of chromatographic science

DOI: https://doi.org/10.1093/chromsci/bmaa118

Paper Quality by design (QbD) based development of a stability indicating HPLC method for drug and impurities.

Karmarkar, S; Garber, R; Genchanok, Y et al. · 2011 · Journal of chromatographic science · DOI

Full title: Quality by design (QbD) based development of a stability indicating HPLC method for drug and impurities.

Authors: Karmarkar, S; Garber, R; Genchanok, Y; George, S; Yang, X; Hammond, R

Year: 2011

Venue: Journal of chromatographic science

DOI: https://doi.org/10.1093/chrsci/49.6.439

Paper Antagonistic effects of chemical mixtures on the oxidative stress response are silenced by heat stress and reversed under dietary restriction.

Arulalan, Karthik Suresh; Huayta, Javier; Stallrich, Jonathan W et al. · 2021 · Exposome · DOI

Full title: Antagonistic effects of chemical mixtures on the oxidative stress response are silenced by heat stress and reversed under dietary restriction.

Authors: Arulalan, Karthik Suresh; Huayta, Javier; Stallrich, Jonathan W; San-Miguel, Adriana

Year: 2021

Venue: Exposome

DOI: https://doi.org/10.1093/exposome/osab005

Paper Vegan grade medium component screening and concentration optimization for the fermentation of the probiotic strain Lactobacillus paracasei IMC 502® using Design of Experiments.

Parecha, Darshankumar; Alfano, Alberto; Cimini, Donatella et al. · 2024 · Journal of industrial microbiology & biotechnology · DOI

Full title: Vegan grade medium component screening and concentration optimization for the fermentation of the probiotic strain Lactobacillus paracasei IMC 502® using Design of Experiments.

Authors: Parecha, Darshankumar; Alfano, Alberto; Cimini, Donatella; Schiraldi, Chiara

Year: 2024

Venue: Journal of industrial microbiology & biotechnology

DOI: https://doi.org/10.1093/jimb/kuae016

Paper Analytical Quality by Design as an Important Tool to Determine the Best Analytical Conditions for Isoniazid and Its Respective Succinylated Prodrug.

Rampini, Denise; de Araújo, Renan Vinícius; Foitinho, Rodrigo Esteves et al. · 2021 · Journal of AOAC International · DOI

Full title: Analytical Quality by Design as an Important Tool to Determine the Best Analytical Conditions for Isoniazid and Its Respective Succinylated Prodrug.

Authors: Rampini, Denise; de Araújo, Renan Vinícius; Foitinho, Rodrigo Esteves; Lourenço, Felipe Rebello; Giarolla, Jeanine

Year: 2021

Venue: Journal of AOAC International

DOI: https://doi.org/10.1093/jaoacint/qsaa087

Paper Algorithmic co-optimization of genetic constructs and growth conditions: application to 6-ACA, a potential nylon-6 precursor.

Zhou, Hui; Vonk, Brenda; Roubos, Johannes A et al. · 2015 · Nucleic acids research · DOI

Full title: Algorithmic co-optimization of genetic constructs and growth conditions: application to 6-ACA, a potential nylon-6 precursor.

Authors: Zhou, Hui; Vonk, Brenda; Roubos, Johannes A; Bovenberg, Roel A L; Voigt, Christopher A

Year: 2015

Venue: Nucleic acids research

DOI: https://doi.org/10.1093/nar/gkv1071

Paper Red, Green, and Blue Model-Based Assessment and Principles of White Analytical Chemistry to Robust Stability-Indicating Chromatographic Estimation of Thiocolchicoside and Diclofenac Sodium.

Prajapati, Pintu; Pulusu, Veera Shakar; Shah, Shailesh · 2023 · Journal of AOAC International · DOI

Full title: Red, Green, and Blue Model-Based Assessment and Principles of White Analytical Chemistry to Robust Stability-Indicating Chromatographic Estimation of Thiocolchicoside and Diclofenac Sodium.

Authors: Prajapati, Pintu; Pulusu, Veera Shakar; Shah, Shailesh

Year: 2023

Venue: Journal of AOAC International

DOI: https://doi.org/10.1093/jaoacint/qsad052

Paper Horwitz’s Rule, Transforming Both Sides and the Design of Experiments for Mechanistic Models

Atkinson, Anthony C. · 2003 · Journal of the Royal Statistical Society Series C (Applied Statistics) · DOI

Full title: Horwitz’s Rule, Transforming Both Sides and the Design of Experiments for Mechanistic Models

Authors: Atkinson, Anthony C.

Year: 2003

Venue: Journal of the Royal Statistical Society Series C (Applied Statistics)

DOI: https://doi.org/10.1111/1467-9876.00403

Paper Design and Optimization of a Passive Micromixer with Kite-Shaped Chambers

Israt Zahan Nishu; M. F. Samad · 2023 · European Conference on Cognitive Ergonomics · DOI

Full title: Design and Optimization of a Passive Micromixer with Kite-Shaped Chambers

Authors: Israt Zahan Nishu; M. F. Samad

Year: 2023

Venue: European Conference on Cognitive Ergonomics

DOI: https://doi.org/10.1109/ecce57851.2023.10101610

Paper Improvement Acid Pretreatment of Corn Stover for Efficient Pentose Production

María Elizabeth Delfín Ruíz; Eric Onofre Ruiz; Juan Antonio Pinilla Rodríguez et al. · 2024 · 2024 IEEE International Conference on Engineering Veracruz (ICEV) · DOI

Full title: Improvement Acid Pretreatment of Corn Stover for Efficient Pentose Production

Authors: María Elizabeth Delfín Ruíz; Eric Onofre Ruiz; Juan Antonio Pinilla Rodríguez; Sergio Román Jara; Carlos Javier Gasca Caballero

Year: 2024

Venue: 2024 IEEE International Conference on Engineering Veracruz (ICEV)

DOI: https://doi.org/10.1109/icev63254.2024.10766010

Paper Evolving Neuro-Fuzzy Systems-Based Design of Experiments in Process Identification

Ožbot, Miha; Lughofer, Edwin; Škrjanc, Igor · 2022 · IEEE Transactions on Fuzzy Systems · DOI

Full title: Evolving Neuro-Fuzzy Systems-Based Design of Experiments in Process Identification

Authors: Ožbot, Miha; Lughofer, Edwin; Škrjanc, Igor

Year: 2022

Venue: IEEE Transactions on Fuzzy Systems

DOI: https://doi.org/10.1109/tfuzz.2022.3216992

Paper Evolving Fuzzy-Model-Based Design of Experiments With Supervised Hierarchical Clustering

Škrjanc, Igor · 2014 · IEEE Transactions on Fuzzy Systems · DOI

Full title: Evolving Fuzzy-Model-Based Design of Experiments With Supervised Hierarchical Clustering

Authors: Škrjanc, Igor

Year: 2014

Venue: IEEE Transactions on Fuzzy Systems

DOI: https://doi.org/10.1109/tfuzz.2014.2329711

Paper l-asparaginase production by isolated Staphylococcus sp. ? 6A: design of experiment considering interaction effect for process parameter optimization

Prakasham, R. S.; Rao, Ch. Subba; Rao, R. Sreenivas et al. · 2006 · Journal of Applied Microbiology · DOI

Full title: l-asparaginase production by isolated Staphylococcus sp. ? 6A: design of experiment considering interaction effect for process parameter optimization

Authors: Prakasham, R. S.; Rao, Ch. Subba; Rao, R. Sreenivas; Lakshmi, G. Suvarna; Sarma, P.N.

Year: 2006

Venue: Journal of Applied Microbiology

DOI: https://doi.org/10.1111/j.1365-2672.2006.03173.x

Paper Efficient Design of Experiments in the Monod Model

Dette, Holger; Melas, Viatcheslav B.; Pepelyshev, Andrey et al. · 2003 · Journal of the Royal Statistical Society Series B (Statistical Methodology) · DOI

Full title: Efficient Design of Experiments in the Monod Model

Authors: Dette, Holger; Melas, Viatcheslav B.; Pepelyshev, Andrey; Strigul, Nikolai

Year: 2003

Venue: Journal of the Royal Statistical Society Series B (Statistical Methodology)

DOI: https://doi.org/10.1111/1467-9868.00412

Paper A tutorial on design of experiments for simulation modeling

Law, Averill M. · 2014 · Proceedings of the Winter Simulation Conference 2014 · DOI

Full title: A tutorial on design of experiments for simulation modeling

Authors: Law, Averill M.

Year: 2014

Venue: Proceedings of the Winter Simulation Conference 2014

DOI: https://doi.org/10.1109/wsc.2014.7019878

Paper A tutorial on design of experiments for simulation modeling

Law, Averill M. · 2014 · Proceedings of the Winter Simulation Conference 2014 · DOI

Full title: A tutorial on design of experiments for simulation modeling

Authors: Law, Averill M.

Year: 2014

Venue: Proceedings of the Winter Simulation Conference 2014

DOI: https://doi.org/10.1109/wsc.2014.7019878

Paper Taguchi approach significantly increases bioremediation process efficiency: a case study with Hg (II) removal by Pseudomonas aeruginosa.

Tupe, S G; Rajwade, J M; Paknikar, K M · 2007 · Letters in applied microbiology · DOI

Full title: Taguchi approach significantly increases bioremediation process efficiency: a case study with Hg (II) removal by Pseudomonas aeruginosa.

Authors: Tupe, S G; Rajwade, J M; Paknikar, K M

Year: 2007

Venue: Letters in applied microbiology

DOI: https://doi.org/10.1111/j.1472-765X.2007.02152.x

Paper High level extracellular production of recombinant human interferon alpha 2b in glycoengineered Pichia pastoris: culture medium optimization, high cell density cultivation and biological characterization.

Katla, S; Karmakar, B; Tadi, S R R et al. · 2019 · Journal of applied microbiology · DOI

Full title: High level extracellular production of recombinant human interferon alpha 2b in glycoengineered Pichia pastoris: culture medium optimization, high cell density cultivation and biological characterization.

Authors: Katla, S; Karmakar, B; Tadi, S R R; Mohan, N; Anand, B; Pal, U; Sivaprakasam, S

Year: 2019

Venue: Journal of applied microbiology

DOI: https://doi.org/10.1111/jam.14227

Paper Optimization of β-casein stabilized nanoemulsions using experimental mixture design.

Maher, Patrick G; Fenelon, Mark A; Zhou, Yankun et al. · 2011 · Journal of food science · DOI

Full title: Optimization of β-casein stabilized nanoemulsions using experimental mixture design.

Authors: Maher, Patrick G; Fenelon, Mark A; Zhou, Yankun; Kamrul Haque, Md; Roos, Yrjö H

Year: 2011

Venue: Journal of food science

DOI: https://doi.org/10.1111/j.1750-3841.2011.02343.x

Paper Lipase Catalyzed Synthesis of ABA‐Type Structured Lipid from Single Cell Oil and Tripalmitin

Sibao Liu; Xu-yan Dong; F. Wei et al. · 2017 · DOI

Full title: Lipase Catalyzed Synthesis of ABA‐Type Structured Lipid from Single Cell Oil and Tripalmitin

Authors: Sibao Liu; Xu-yan Dong; F. Wei; Xiang Wang; Xin Lv; Lin-dong Wu; S. Quek; Hong Chen

Year: 2017

DOI: https://doi.org/10.1111/jfpp.12843

Paper Design of Experiments with Both Mixture and Qualitative Factors

Donev, A N · 1989 · Journal of the Royal Statistical Society Series B (Statistical Methodology) · DOI

Full title: Design of Experiments with Both Mixture and Qualitative Factors

Authors: Donev, A N

Year: 1989

Venue: Journal of the Royal Statistical Society Series B (Statistical Methodology)

DOI: https://doi.org/10.1111/j.2517-6161.1989.tb01767.x

Paper Biosynthesis of Amyl Alcohol From Scenedesmus quadricauda Microalgae for Light Commercial Vehicle Compression Ignition Engine Using Prediction Models

Ashwin Jacob; B. Ashok · 2021 · Journal of energy resources technology · DOI

Full title: Biosynthesis of Amyl Alcohol From Scenedesmus quadricauda Microalgae for Light Commercial Vehicle Compression Ignition Engine Using Prediction Models

Authors: Ashwin Jacob; B. Ashok

Year: 2021

Venue: Journal of energy resources technology

DOI: https://doi.org/10.1115/1.4052542

Paper Optimal Design of Experiments for Non-Linear Response Surface Models

Huang, Yuanzhi; Gilmour, Steven G.; Mylona, Kalliopi et al. · 2018 · Journal of the Royal Statistical Society Series C (Applied Statistics) · DOI

Full title: Optimal Design of Experiments for Non-Linear Response Surface Models

Authors: Huang, Yuanzhi; Gilmour, Steven G.; Mylona, Kalliopi; Goos, Peter

Year: 2018

Venue: Journal of the Royal Statistical Society Series C (Applied Statistics)

DOI: https://doi.org/10.1111/rssc.12313

Paper On the Use of Statistics in Design and the Implications for Deterministic Computer Experiments

Simpson, Timothy W.; Peplinski, Jesse; Koch, Patrick et al. · 1997 · DOI

Full title: On the Use of Statistics in Design and the Implications for Deterministic Computer Experiments

Authors: Simpson, Timothy W.; Peplinski, Jesse; Koch, Patrick; Allen, Janet K.

Year: 1997

DOI: https://doi.org/10.1115/detc97/dtm-3881

Paper Bayesian Optimal Design of Experiments for Inferring the Statistical Expectation of Expensive Black-Box Functions

Pandita, Piyush; Bilionis, Ilias; Panchal, Jitesh H. · 2019 · Journal of Mechanical Design · DOI

Full title: Bayesian Optimal Design of Experiments for Inferring the Statistical Expectation of Expensive Black-Box Functions

Authors: Pandita, Piyush; Bilionis, Ilias; Panchal, Jitesh H.

Year: 2019

Venue: Journal of Mechanical Design

DOI: https://doi.org/10.1115/1.4043930

Paper Application of statistical experimental design to optimize culture requirements of Aspergillus sp. Zh-26 producing xylanase for degradation of arabinoxylans in mashing.

Li, Y; Liu, Z; Cui, F et al. · 2007 · Journal of food science · DOI

Full title: Application of statistical experimental design to optimize culture requirements of Aspergillus sp. Zh-26 producing xylanase for degradation of arabinoxylans in mashing.

Authors: Li, Y; Liu, Z; Cui, F; Xu, Y; Zhao, H; Liu, Z

Year: 2007

Venue: Journal of food science

DOI: https://doi.org/10.1111/j.1750-3841.2007.00389.x

Paper Metabolic engineering of Lactobacillus helveticus CNRZ32 for production of pure L-(+)-lactic acid.

Kylä-Nikkilä, K; Hujanen, M; Leisola, M et al. · 2000 · Applied and environmental microbiology · DOI

Full title: Metabolic engineering of Lactobacillus helveticus CNRZ32 for production of pure L-(+)-lactic acid.

Authors: Kylä-Nikkilä, K; Hujanen, M; Leisola, M; Palva, A

Year: 2000

Venue: Applied and environmental microbiology

DOI: https://doi.org/10.1128/AEM.66.9.3835-3841.2000

Paper Optimization of medium composition for lipase production by Candida rugosa NCIM 3462 using response surface methodology.

Rajendran, Aravindan; Thangavelu, Viruthagiri · 2007 · Canadian journal of microbiology · DOI

Full title: Optimization of medium composition for lipase production by Candida rugosa NCIM 3462 using response surface methodology.

Authors: Rajendran, Aravindan; Thangavelu, Viruthagiri

Year: 2007

Venue: Canadian journal of microbiology

DOI: https://doi.org/10.1139/W07-017

Paper Applying Statistical Design of Experiments To Understanding the Effect of Growth Medium Components on Cupriavidus necator H16 Growth.

Azubuike, Christopher C; Edwards, Martin G; Gatehouse, Angharad M R et al. · 2020 · Applied and environmental microbiology · DOI

Full title: Applying Statistical Design of Experiments To Understanding the Effect of Growth Medium Components on Cupriavidus necator H16 Growth.

Authors: Azubuike, Christopher C; Edwards, Martin G; Gatehouse, Angharad M R; Howard, Thomas P

Year: 2020

Venue: Applied and environmental microbiology

DOI: https://doi.org/10.1128/AEM.00705-20

Paper Sequential Design of Experiment for Sparse Polynomial Chaos Expansions

Fajraoui, Noura; Marelli, Stefano; Sudret, Bruno · 2017 · SIAM/ASA Journal on Uncertainty Quantification · DOI

Full title: Sequential Design of Experiment for Sparse Polynomial Chaos Expansions

Authors: Fajraoui, Noura; Marelli, Stefano; Sudret, Bruno

Year: 2017

Venue: SIAM/ASA Journal on Uncertainty Quantification

DOI: https://doi.org/10.1137/16m1103488

Paper Pareto front genetic programming parameter selection based on design of experiments and industrial data

Castillo, Flor; Kordon, Arthur K.; Smits, Guido et al. · 2006 · DOI

Full title: Pareto front genetic programming parameter selection based on design of experiments and industrial data

Authors: Castillo, Flor; Kordon, Arthur K.; Smits, Guido; Christenson, Ben; Dickerson, Dee

Year: 2006

DOI: https://doi.org/10.1145/1143997.1144264

Paper Limitations of Statistical Design of Experiments Approaches in Engineering Testing

Deaconu, Stelu; Coleman, Hugh W. · 2000 · Journal of Fluids Engineering · DOI

Full title: Limitations of Statistical Design of Experiments Approaches in Engineering Testing

Authors: Deaconu, Stelu; Coleman, Hugh W.

Year: 2000

Venue: Journal of Fluids Engineering

DOI: https://doi.org/10.1115/1.483252

Paper 23 Full Factorial Model for Particle Size Optimization of Methotrexate Loaded Chitosan Nanocarriers: A Design of Experiments (DoE) Approach.

Teja, S P Surya; Damodharan, N · 2018 · BioMed research international · DOI

Full title: 23 Full Factorial Model for Particle Size Optimization of Methotrexate Loaded Chitosan Nanocarriers: A Design of Experiments (DoE) Approach.

Authors: Teja, S P Surya; Damodharan, N

Year: 2018

Venue: BioMed research international

DOI: https://doi.org/10.1155/2018/7834159

Paper Obtaining Acid-sensitive Prosaikogenin F by Enzymatic Hydrolysis of Saikosaponin A

Yeting Zhu; Jiangsong Peng; Yaqin Zhao et al. · 2023 · Pharmacognosy Magazine · DOI

Full title: Obtaining Acid-sensitive Prosaikogenin F by Enzymatic Hydrolysis of Saikosaponin A

Authors: Yeting Zhu; Jiangsong Peng; Yaqin Zhao; Mengru Wu; Suping Chen; Jiali Shao; Xubo Wang; G. Xia; Yuping Shen

Year: 2023

Venue: Pharmacognosy Magazine

DOI: https://doi.org/10.1177/09731296231169577

Paper Optimization of a Colorimetric Assay to Determine Lactate Dehydrogenase B Activity Using Design of Experiments.

Papaneophytou, Christos; Zervou, Maria-Elli; Theofanous, Anastasis · 2021 · SLAS discovery : advancing life sciences R & D · DOI

Full title: Optimization of a Colorimetric Assay to Determine Lactate Dehydrogenase B Activity Using Design of Experiments.

Authors: Papaneophytou, Christos; Zervou, Maria-Elli; Theofanous, Anastasis

Year: 2021

Venue: SLAS discovery : advancing life sciences R & D

DOI: https://doi.org/10.1177/2472555220956589

Paper Optimization of polygalacturonase production from a newly isolated Thalassospira frigidphilosprofundus to use in pectin hydrolysis: statistical approach.

Rekha, V P B; Ghosh, Mrinmoy; Adapa, Vijayanand et al. · 2013 · BioMed research international · DOI

Full title: Optimization of polygalacturonase production from a newly isolated Thalassospira frigidphilosprofundus to use in pectin hydrolysis: statistical approach.

Authors: Rekha, V P B; Ghosh, Mrinmoy; Adapa, Vijayanand; Oh, Sung-Jong; Pulicherla, K K; Sambasiva Rao, K R S

Year: 2013

Venue: BioMed research international

DOI: https://doi.org/10.1155/2013/750187

Paper A General Guide for the Optimization of Enzyme Assay Conditions Using the Design of Experiments Approach.

Onyeogaziri, Favour Chinyere; Papaneophytou, Christos · 2019 · SLAS discovery : advancing life sciences R & D · DOI

Full title: A General Guide for the Optimization of Enzyme Assay Conditions Using the Design of Experiments Approach.

Authors: Onyeogaziri, Favour Chinyere; Papaneophytou, Christos

Year: 2019

Venue: SLAS discovery : advancing life sciences R & D

DOI: https://doi.org/10.1177/2472555219830084

Paper Production and characterization of alginate microcapsules produced by a vibrational encapsulation device.

Mazzitelli, S; Tosi, A; Balestra, C et al. · 2008 · Journal of biomaterials applications · DOI

Full title: Production and characterization of alginate microcapsules produced by a vibrational encapsulation device.

Authors: Mazzitelli, S; Tosi, A; Balestra, C; Nastruzzi, C; Luca, G; Mancuso, F; Calafiore, R; Calvitti, M

Year: 2008

Venue: Journal of biomaterials applications

DOI: https://doi.org/10.1177/0885328207084958

Paper Optimization of Concentrated Sulphuric Acid Hydrolysis of Gadam Sorghum Stalks Found in Kenya for Fermentable Sugar Production

Wiseman Ngigi; Z. Siagi; Anil Kumar et al. · 2022 · Journal of Energy · DOI

Full title: Optimization of Concentrated Sulphuric Acid Hydrolysis of Gadam Sorghum Stalks Found in Kenya for Fermentable Sugar Production

Authors: Wiseman Ngigi; Z. Siagi; Anil Kumar; Moses Arowo

Year: 2022

Venue: Journal of Energy

DOI: https://doi.org/10.1155/2022/2064600

Paper Optimizing the generation of mature bone marrow-derived dendritic cells in vitro: a factorial study design.

Alotaibi, Najla; Aldahlawi, Alia; Zaher, Kawther et al. · 2023 · Journal, genetic engineering & biotechnology · DOI

Full title: Optimizing the generation of mature bone marrow-derived dendritic cells in vitro: a factorial study design.

Authors: Alotaibi, Najla; Aldahlawi, Alia; Zaher, Kawther; Basingab, Fatemah; Alrahimi, Jehan

Year: 2023

Venue: Journal, genetic engineering & biotechnology

DOI: https://doi.org/10.1186/s43141-023-00597-4

Paper Application of DOE to ELISA Robustness and Ruggedness Assessment.

Follmer, Thy; Clark, Seth; Verch, Thorsten · 2025 · The AAPS journal · DOI

Full title: Application of DOE to ELISA Robustness and Ruggedness Assessment.

Authors: Follmer, Thy; Clark, Seth; Verch, Thorsten

Year: 2025

Venue: The AAPS journal

DOI: https://doi.org/10.1208/s12248-025-01048-3

Paper Statistical optimization of gastric floating system for oral controlled delivery of calcium.

Li, S; Lin, S; Chien, Y W et al. · 2001 · AAPS PharmSciTech · DOI

Full title: Statistical optimization of gastric floating system for oral controlled delivery of calcium.

Authors: Li, S; Lin, S; Chien, Y W; Daggy, B P; Mirchandani, H L

Year: 2001

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/pt020101

Paper Application of quality by design to the process development of botanical drug products: a case study.

Zhang, Lei; Yan, Binjun; Gong, Xingchu et al. · 2013 · AAPS PharmSciTech · DOI

Full title: Application of quality by design to the process development of botanical drug products: a case study.

Authors: Zhang, Lei; Yan, Binjun; Gong, Xingchu; Yu, Lawrence X; Qu, Haibin

Year: 2013

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-012-9919-8

Paper Optimization of process parameters for a quasi-continuous tablet coating system using design of experiments.

Cahyadi, Christine; Heng, Paul Wan Sia; Chan, Lai Wah · 2011 · AAPS PharmSciTech · DOI

Full title: Optimization of process parameters for a quasi-continuous tablet coating system using design of experiments.

Authors: Cahyadi, Christine; Heng, Paul Wan Sia; Chan, Lai Wah

Year: 2011

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-010-9567-9

Paper Study of the Influence of Formulation Variables in Bioadhesive Emulgels Using Response Surface Methodology.

Ochoa-Andrade, Ana; Parente, M Emma; Jimenez-Kairuz, Álvaro et al. · 2017 · AAPS PharmSciTech · DOI

Full title: Study of the Influence of Formulation Variables in Bioadhesive Emulgels Using Response Surface Methodology.

Authors: Ochoa-Andrade, Ana; Parente, M Emma; Jimenez-Kairuz, Álvaro; Boinbaser, Lucía; Torregrosa, Annibal

Year: 2017

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-016-0707-8

Paper Investigating a Novel Hot Melt Extrusion-Based Drying Technique to Solidify an Amorphous Nanosuspension Using Design of Experiment Methodology.

Gajera, Bhavin Y; Shah, Dhaval A; Dave, Rutesh H · 2018 · AAPS PharmSciTech · DOI

Full title: Investigating a Novel Hot Melt Extrusion-Based Drying Technique to Solidify an Amorphous Nanosuspension Using Design of Experiment Methodology.

Authors: Gajera, Bhavin Y; Shah, Dhaval A; Dave, Rutesh H

Year: 2018

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-018-1189-7

Paper Scale up of Semisolid Dosage Forms Manufacturing Based on Process Understanding: from Lab to Industrial Scale.

van Heugten, Anton J P; Vromans, Herman · 2018 · AAPS PharmSciTech · DOI

Full title: Scale up of Semisolid Dosage Forms Manufacturing Based on Process Understanding: from Lab to Industrial Scale.

Authors: van Heugten, Anton J P; Vromans, Herman

Year: 2018

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-018-1063-7

Paper Understanding the Effects of Associated Factors in the Development of Microsponge-Based Drug Delivery: a Statistical Quality by Design (QbD) Approach Towards Optimization.

Karmakar, Shibam; Poddar, Sourav; Khanam, Jasmina · 2022 · AAPS PharmSciTech · DOI

Full title: Understanding the Effects of Associated Factors in the Development of Microsponge-Based Drug Delivery: a Statistical Quality by Design (QbD) Approach Towards Optimization.

Authors: Karmakar, Shibam; Poddar, Sourav; Khanam, Jasmina

Year: 2022

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-022-02409-3

Paper A Systematic Approach of Employing Quality by Design Principles: Risk Assessment and Design of Experiments to Demonstrate Process Understanding and Identify the Critical Process Parameters for Coating of the Ethylcellulose Pseudolatex Dispersion Using Non-Conventional Fluid Bed Process.

Kothari, Bhaveshkumar H; Fahmy, Raafat; Claycamp, H Gregg et al. · 2017 · AAPS PharmSciTech · DOI

Full title: A Systematic Approach of Employing Quality by Design Principles: Risk Assessment and Design of Experiments to Demonstrate Process Understanding and Identify the Critical Process Parameters for Coating of the Ethylcellulose Pseudolatex Dispersion Using Non-Conventional Fluid Bed Process.

Authors: Kothari, Bhaveshkumar H; Fahmy, Raafat; Claycamp, H Gregg; Moore, Christine M V; Chatterjee, Sharmista; Hoag, Stephen W

Year: 2017

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-016-0569-0

Paper A Data-Mining Approach for the Quantitative Assessment of Physicochemical Properties of Molecular Compounds in the Skin Flux.

Choi, Hoo-Kyun; Acharya, Gayathri; Lee, Yugyung et al. · 2021 · AAPS PharmSciTech · DOI

Full title: A Data-Mining Approach for the Quantitative Assessment of Physicochemical Properties of Molecular Compounds in the Skin Flux.

Authors: Choi, Hoo-Kyun; Acharya, Gayathri; Lee, Yugyung; Lee, Chi H

Year: 2021

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-021-01988-x

Paper Production of Lysozyme-PLGA-Loaded Microparticles for Controlled Release Using Hot-Melt Extrusion.

Farinha, Susana; Moura, Cláudia; Afonso, Maria Diná et al. · 2020 · AAPS PharmSciTech · DOI

Full title: Production of Lysozyme-PLGA-Loaded Microparticles for Controlled Release Using Hot-Melt Extrusion.

Authors: Farinha, Susana; Moura, Cláudia; Afonso, Maria Diná; Henriques, João

Year: 2020

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-020-01816-8

Paper Use of a Design of Experiments (DoE) Approach to Optimize Large-Scale Freeze-Thaw Process of Biologics.

Minatovicz, Bruna; Bogner, Robin; Chaudhuri, Bodhisattwa · 2021 · AAPS PharmSciTech · DOI

Full title: Use of a Design of Experiments (DoE) Approach to Optimize Large-Scale Freeze-Thaw Process of Biologics.

Authors: Minatovicz, Bruna; Bogner, Robin; Chaudhuri, Bodhisattwa

Year: 2021

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-021-02034-6

Paper Strategizing Spray Drying Process Optimization for the Manufacture of Redispersible Indomethacin Nanoparticles Using Quality-by-Design Principles.

Rathod, Vishal; Gajera, Bhavin; Pinninti, Anusha et al. · 2023 · AAPS PharmSciTech · DOI

Full title: Strategizing Spray Drying Process Optimization for the Manufacture of Redispersible Indomethacin Nanoparticles Using Quality-by-Design Principles.

Authors: Rathod, Vishal; Gajera, Bhavin; Pinninti, Anusha; Mohammed, Irfan A; Dave, Rutesh H

Year: 2023

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-023-02589-6

Paper Computational Enhancements to Bayesian Design of Experiments Using Gaussian Processes

B. Weaver; B. Williams; C. Anderson‐Cook et al. · 2016 · Bayesian Analysis · DOI

Full title: Computational Enhancements to Bayesian Design of Experiments Using Gaussian Processes

Authors: B. Weaver; B. Williams; C. Anderson‐Cook; D. Higdon

Year: 2016

Venue: Bayesian Analysis

DOI: https://doi.org/10.1214/15-ba945

Paper Design of Experiments-Driven Optimization of Spray Drying for Amorphous Clotrimazole Nanosuspension.

Gajera, Bhavin; Shah, Harsh; Parekh, Bhavin et al. · 2024 · AAPS PharmSciTech · DOI

Full title: Design of Experiments-Driven Optimization of Spray Drying for Amorphous Clotrimazole Nanosuspension.

Authors: Gajera, Bhavin; Shah, Harsh; Parekh, Bhavin; Rathod, Vishal; Tilala, Mitul; Dave, Rutesh H

Year: 2024

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-024-02871-1

Paper Loteprednol-Loaded Nanoformulations for Corneal Delivery by Quality-by-Design Concepts: Optimization, Characterization, and Anti-inflammatory Activity.

Uner, Burcu; Ozdemir, Samet; Tas, Cetin et al. · 2023 · AAPS PharmSciTech · DOI

Full title: Loteprednol-Loaded Nanoformulations for Corneal Delivery by Quality-by-Design Concepts: Optimization, Characterization, and Anti-inflammatory Activity.

Authors: Uner, Burcu; Ozdemir, Samet; Tas, Cetin; Uner, Melike; Ozsoy, Yildiz

Year: 2023

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-023-02551-6

Paper The Influence of pH and Preservative Agents on Physicochemical and Microbiological Stability of a Flexible Dose/Age-Appropriate Formulation of Enalapril Maleate. A Quality by Design‑Based Optimization.

Morri, Mauro; Operto, María Alejandra; Maggio, Rubén et al. · 2025 · AAPS PharmSciTech · DOI

Full title: The Influence of pH and Preservative Agents on Physicochemical and Microbiological Stability of a Flexible Dose/Age-Appropriate Formulation of Enalapril Maleate. A Quality by Design‑Based Optimization.

Authors: Morri, Mauro; Operto, María Alejandra; Maggio, Rubén; Leonardi, Darío; Vignaduzzo, Silvana

Year: 2025

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-025-03262-w

Paper Optimization of critical medium components using response surface methodology for phenazine-1-carboxylic acid production by Pseudomonas sp. M-18Q.

Yuan, Li-Li; Li, Ya-Qian; Wang, Yi et al. · 2008 · Journal of bioscience and bioengineering · DOI

Full title: Optimization of critical medium components using response surface methodology for phenazine-1-carboxylic acid production by Pseudomonas sp. M-18Q.

Authors: Yuan, Li-Li; Li, Ya-Qian; Wang, Yi; Zhang, Xue-Hong; Xu, Yu-Quan

Year: 2008

Venue: Journal of bioscience and bioengineering

DOI: https://doi.org/10.1263/jbb.105.232

Paper Perturbation Study of Dissolution Apparatus Variables—A Design of Experiment Approach

Eaton, Joseph W.; Deng, Gang; Hauck, Walter W. et al. · 2007 · Dissolution Technologies · DOI

Full title: Perturbation Study of Dissolution Apparatus Variables—A Design of Experiment Approach

Authors: Eaton, Joseph W.; Deng, Gang; Hauck, Walter W.; Brown, William E.; Manning, Ronald G.; Wahab, Samir

Year: 2007

Venue: Dissolution Technologies

DOI: https://doi.org/10.14227/dt140107p20

Paper Statistical experimental design for bioprocess modeling and optimization analysis: repeated-measures method for dynamic biotechnology process.

Lee, Kwang-Min; Gilmore, David F · 2006 · Applied biochemistry and biotechnology · DOI

Full title: Statistical experimental design for bioprocess modeling and optimization analysis: repeated-measures method for dynamic biotechnology process.

Authors: Lee, Kwang-Min; Gilmore, David F

Year: 2006

Venue: Applied biochemistry and biotechnology

DOI: https://doi.org/10.1385/abab:135:2:101

Paper Response surface methodology for lovastatin production by Aspergillus terreus GD13 strain.

Kaur, Harleen; Kaur, Amarjeet; Saini, Harvinder Singh et al. · 2010 · Acta microbiologica et immunologica Hungarica · DOI

Full title: Response surface methodology for lovastatin production by Aspergillus terreus GD13 strain.

Authors: Kaur, Harleen; Kaur, Amarjeet; Saini, Harvinder Singh; Chadha, Bhupinder Singh

Year: 2010

Venue: Acta microbiologica et immunologica Hungarica

DOI: https://doi.org/10.1556/AMicr.57.2010.4.4

Paper Bioprocess Optimization of L-Lysine Production by Using RSM and Artificial Neural Networks from Corynebacterium glutamicum ATCC13032

V. Bhushanam; Ramesh Malothu · 2020 · DOI

Full title: Bioprocess Optimization of L-Lysine Production by Using RSM and Artificial Neural Networks from Corynebacterium glutamicum ATCC13032

Authors: V. Bhushanam; Ramesh Malothu

Year: 2020

DOI: https://doi.org/10.1515/cppm-2019-0054

Paper ISOLATION OF PHOSPHATE SOLUBILIZING MICROORGANISMS AND OPTIMIZATION OF THEIR FERMENTATION CONDITIONS BY STATISTICAL TECHNIQUE USING AGRO-INDUSTRIAL WASTE

R. Tahir; A. Adnan; N. Ullah et al. · 2025 · Applied Ecology and Environmental Research · DOI

Full title: ISOLATION OF PHOSPHATE SOLUBILIZING MICROORGANISMS AND OPTIMIZATION OF THEIR FERMENTATION CONDITIONS BY STATISTICAL TECHNIQUE USING AGRO-INDUSTRIAL WASTE

Authors: R. Tahir; A. Adnan; N. Ullah; A. Sarwar; R. Nelofer; F. Bashir; M. Nadeem; T. Aziz; M. Alharbi; A. F. Alasmari; T. Albekairi

Year: 2025

Venue: Applied Ecology and Environmental Research

DOI: https://doi.org/10.15666/aeer/2302_28072819

Paper Optimizing drug delivery systems using systematic "design of experiments." Part I: fundamental aspects.

Singh, Bhupinder; Kumar, Rajiv; Ahuja, Naveen · 2005 · Critical reviews in therapeutic drug carrier systems · DOI

Full title: Optimizing drug delivery systems using systematic "design of experiments." Part I: fundamental aspects.

Authors: Singh, Bhupinder; Kumar, Rajiv; Ahuja, Naveen

Year: 2005

Venue: Critical reviews in therapeutic drug carrier systems

DOI: https://doi.org/10.1615/critrevtherdrugcarriersyst.v22.i1.20

Paper Chemometrics approach for optimization of capillary electrophoretic conditions for the separation of insulin analogues.

Pajaziti, B; Andrási, M; Nebija, D et al. · 2021 · Die Pharmazie · DOI

Full title: Chemometrics approach for optimization of capillary electrophoretic conditions for the separation of insulin analogues.

Authors: Pajaziti, B; Andrási, M; Nebija, D; Pajaziti, B A; Anastasova, L; Petkovska, R

Year: 2021

Venue: Die Pharmazie

DOI: https://doi.org/10.1691/ph.2021.1758

Paper Statistical Optimization of Parameters for the Enhancement of Lipase Activity

P. Das; Soham Chattopadhyay · 2020 · DOI

Full title: Statistical Optimization of Parameters for the Enhancement of Lipase Activity

Authors: P. Das; Soham Chattopadhyay

Year: 2020

DOI: https://doi.org/10.21203/rs.3.rs-18005/v1

Paper Introducing an Experimental Design Approach for Efficient Optimization of Chiral Derivatization Conditions for D- and L-Glyceric Acids.

Takayama, Takahiro; Mizuno, Hajime; Toyo'oka, Toshimasa et al. · 2019 · Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · DOI

Full title: Introducing an Experimental Design Approach for Efficient Optimization of Chiral Derivatization Conditions for D- and L-Glyceric Acids.

Authors: Takayama, Takahiro; Mizuno, Hajime; Toyo'oka, Toshimasa; Todoroki, Kenichiro

Year: 2019

Venue: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

DOI: https://doi.org/10.2116/analsci.19N013

Paper Efecto de la temperatura y tiempo de transesterificación en el rendimiento y poder calórico de biodiesel a partir de grasa refinada de pollo

H. Arteaga; Raúl Siche; Sandra Pagador et al. · 2010 · DOI

Full title: Efecto de la temperatura y tiempo de transesterificación en el rendimiento y poder calórico de biodiesel a partir de grasa refinada de pollo

Authors: H. Arteaga; Raúl Siche; Sandra Pagador; H. Cáceres

Year: 2010

DOI: https://doi.org/10.17268/sci.agropecu.2010.01.04

Paper Effect of Solid State Fermentation Medium Optimization on Pleurotus ostreatus Laccase Production.

Belšak-Šel, Nataša; Gregori, Andrej; Leitgeb, Maja et al. · 2015 · Acta chimica Slovenica · DOI

Full title: Effect of Solid State Fermentation Medium Optimization on Pleurotus ostreatus Laccase Production.

Authors: Belšak-Šel, Nataša; Gregori, Andrej; Leitgeb, Maja; Klinara, Dušan; Čelan, Štefan

Year: 2015

Venue: Acta chimica Slovenica

DOI: https://doi.org/10.17344/acsi.2015.1764

Paper Response surface methodology to optimize inulinase production by a newly isolated Penicillium amphipolaria strain by solid-state fermentation of Saccharum arundinaceum

D. Das; Ramananda M. Bhat; Raja Selvaraj · 2020 · DOI

Full title: Response surface methodology to optimize inulinase production by a newly isolated Penicillium amphipolaria strain by solid-state fermentation of Saccharum arundinaceum

Authors: D. Das; Ramananda M. Bhat; Raja Selvaraj

Year: 2020

DOI: https://doi.org/10.21203/rs.3.rs-33849/v1

Paper Optimizing the coagulation process in a drinking water treatment plant -- comparison between traditional and statistical experimental design jar tests.

Zainal-Abideen, M; Aris, A; Yusof, F et al. · 2012 · Water science and technology : a journal of the International Association on Water Pollution Research · DOI

Full title: Optimizing the coagulation process in a drinking water treatment plant -- comparison between traditional and statistical experimental design jar tests.

Authors: Zainal-Abideen, M; Aris, A; Yusof, F; Abdul-Majid, Z; Selamat, A; Omar, S I

Year: 2012

Venue: Water science and technology : a journal of the International Association on Water Pollution Research

DOI: https://doi.org/10.2166/wst.2012.561

Paper Evaluation and optimization of ASM1 parameters using large-scale WWTP monitoring data from a subtropical climate region in Brazil

Á. C. Martins; M. A. Silva; A. D. Benetti · 2021 · Water practice and technology · DOI

Full title: Evaluation and optimization of ASM1 parameters using large-scale WWTP monitoring data from a subtropical climate region in Brazil

Authors: Á. C. Martins; M. A. Silva; A. D. Benetti

Year: 2021

Venue: Water practice and technology

DOI: https://doi.org/10.2166/wpt.2021.109

Paper Process Variables and Design of Experiments in Liposome and Nanoliposome Research

Zoghi, Alaleh; Khosravi‐Darani, Kianoush; Omri, Abdelwahab · 2018 · Mini-Reviews in Medicinal Chemistry · DOI

Full title: Process Variables and Design of Experiments in Liposome and Nanoliposome Research

Authors: Zoghi, Alaleh; Khosravi‐Darani, Kianoush; Omri, Abdelwahab

Year: 2018

Venue: Mini-Reviews in Medicinal Chemistry

DOI: https://doi.org/10.2174/1389557516666161031120752

Paper Identifying Optimized Parameters to Enhance the Productivity of Gas Generating Pellets Using a Dome Type Extruder.

Patel, Ronak R; Mehta, Dharmik M · 2025 · Recent advances in drug delivery and formulation · DOI

Full title: Identifying Optimized Parameters to Enhance the Productivity of Gas Generating Pellets Using a Dome Type Extruder.

Authors: Patel, Ronak R; Mehta, Dharmik M

Year: 2025

Venue: Recent advances in drug delivery and formulation

DOI: https://doi.org/10.2174/0126673878351312250502072134

Paper Systematic Development and Optimization of an in-situ Gelling System for Moxifloxacin Ocular Nanosuspension using High-pressure Homogenization with an Improved Encapsulation Efficiency.

Khurana, Lalit Kumar; Singh, Romi; Singh, Harinder et al. · 2018 · Current pharmaceutical design · DOI

Full title: Systematic Development and Optimization of an in-situ Gelling System for Moxifloxacin Ocular Nanosuspension using High-pressure Homogenization with an Improved Encapsulation Efficiency.

Authors: Khurana, Lalit Kumar; Singh, Romi; Singh, Harinder; Sharma, Manju

Year: 2018

Venue: Current pharmaceutical design

DOI: https://doi.org/10.2174/1381612824666180403115106

Paper Recent advancement in application of hydrophobic interaction chromatography for aggregate removal in industrial purification process.

Lu, Yuefeng; Williamson, Brian; Gillespie, Ronald · 2009 · Current pharmaceutical biotechnology · DOI

Full title: Recent advancement in application of hydrophobic interaction chromatography for aggregate removal in industrial purification process.

Authors: Lu, Yuefeng; Williamson, Brian; Gillespie, Ronald

Year: 2009

Venue: Current pharmaceutical biotechnology

DOI: https://doi.org/10.2174/138920109788488897

Paper Simultaneous Optimization of Activity and Stability of Xylose Reductase from D. nepalensis NCYC 3413 Using Statistical Experimental Design.

Malla, Shwethashree; Gummadi, Sathyanarayana N · 2021 · Protein and peptide letters · DOI

Full title: Simultaneous Optimization of Activity and Stability of Xylose Reductase from D. nepalensis NCYC 3413 Using Statistical Experimental Design.

Authors: Malla, Shwethashree; Gummadi, Sathyanarayana N

Year: 2021

Venue: Protein and peptide letters

DOI: https://doi.org/10.2174/0929866527666201103145246

Paper Optimization of Buffer Additives for Efficient Recovery of hGM-CSF from Inclusion Bodies Using Response Surface Methodology.

Ahmadian, Mina; Jahanian-Najafabadi, Ali; Akbari, Vajihe · 2020 · Iranian journal of pharmaceutical research : IJPR · DOI

Full title: Optimization of Buffer Additives for Efficient Recovery of hGM-CSF from Inclusion Bodies Using Response Surface Methodology.

Authors: Ahmadian, Mina; Jahanian-Najafabadi, Ali; Akbari, Vajihe

Year: 2020

Venue: Iranian journal of pharmaceutical research : IJPR

DOI: https://doi.org/10.22037/ijpr.2020.1101169

Paper A New Approach to Modeling Operational Conditions for Mitigating Fouling in Membrane Bioreactor.

Pourabdollah, Mehdi; Torkian, Ayoob; Hosseinzadeh, Majid · 2016 · Water environment research : a research publication of the Water Environment Federation · DOI

Full title: A New Approach to Modeling Operational Conditions for Mitigating Fouling in Membrane Bioreactor.

Authors: Pourabdollah, Mehdi; Torkian, Ayoob; Hosseinzadeh, Majid

Year: 2016

Venue: Water environment research : a research publication of the Water Environment Federation

DOI: https://doi.org/10.2175/106143016X14798353399133

Paper β-galactosidase Production by Aspergillus niger ATCC 9142 Using Inexpensive Substrates in Solid-State Fermentation: Optimization by Orthogonal Arrays Design.

Kazemi, Samaneh; Khayati, Gholam; Faezi-Ghasemi, Mohammad · 2016 · Iranian biomedical journal · DOI

Full title: β-galactosidase Production by Aspergillus niger ATCC 9142 Using Inexpensive Substrates in Solid-State Fermentation: Optimization by Orthogonal Arrays Design.

Authors: Kazemi, Samaneh; Khayati, Gholam; Faezi-Ghasemi, Mohammad

Year: 2016

Venue: Iranian biomedical journal

DOI: https://doi.org/10.22045/ibj.2016.06

Paper Application of response surface methodology to maximize the productivity of scalable automated human embryonic stem cell manufacture.

Ratcliffe, Elizabeth; Hourd, Paul; Guijarro-Leach, Juan et al. · 2013 · Regenerative medicine · DOI

Full title: Application of response surface methodology to maximize the productivity of scalable automated human embryonic stem cell manufacture.

Authors: Ratcliffe, Elizabeth; Hourd, Paul; Guijarro-Leach, Juan; Rayment, Erin; Williams, David J; Thomas, Robert J

Year: 2013

Venue: Regenerative medicine

DOI: https://doi.org/10.2217/rme.12.109

Paper Experimental Investigation of Forced Convective Heat Transfer Coefficient & Pressure Drop in Bi-metallic Plate Heat Exchanger

Q. Ahmed · 2018 · International Journal for Research in Applied Science and Engineering Technology · DOI

Full title: Experimental Investigation of Forced Convective Heat Transfer Coefficient & Pressure Drop in Bi-metallic Plate Heat Exchanger

Authors: Q. Ahmed

Year: 2018

Venue: International Journal for Research in Applied Science and Engineering Technology

DOI: https://doi.org/10.22214/ijraset.2018.6285

Paper Computer Aided Design of Experiments

Kennard, R. W.; Stone, L. A. · 1969 · Technometrics · DOI

Full title: Computer Aided Design of Experiments

Authors: Kennard, R. W.; Stone, L. A.

Year: 1969

Venue: Technometrics

DOI: https://doi.org/10.1080/00401706.1969.10490666

Paper Design and Analysis of Industrial Experiments.

Freeman, H. A.; Davies, O. L.; Box, George E. P. et al. · 1955 · Journal of the American Statistical Association · DOI

Full title: Design and Analysis of Industrial Experiments.

Authors: Freeman, H. A.; Davies, O. L.; Box, George E. P.; Connor, L. R.; Cousins, W. R.; Davies, O. L.; Himsworth, F. R.; Sillitto, G. P.

Year: 1955

Venue: Journal of the American Statistical Association

DOI: https://doi.org/10.2307/2280981

Paper Formulation of the Optimal Latin Hypercube Design of Experiments Using a Permutation Genetic Algorithm

Bates, Stuart J.; Sienz, Johann; Toropov, Vassili · 2004 · DOI

Full title: Formulation of the Optimal Latin Hypercube Design of Experiments Using a Permutation Genetic Algorithm

Authors: Bates, Stuart J.; Sienz, Johann; Toropov, Vassili

Year: 2004

DOI: https://doi.org/10.2514/6.2004-2011

Paper Extraction of Volatile Fatty Acids from Leachate via Liquidliquid Extraction and Adsorption Method

Yasmin Syafikah Razali; H. A. Tajarudin; Z. Daud · 2018 · International Journal of Integrated Engineering · DOI

Full title: Extraction of Volatile Fatty Acids from Leachate via Liquidliquid Extraction and Adsorption Method

Authors: Yasmin Syafikah Razali; H. A. Tajarudin; Z. Daud

Year: 2018

Venue: International Journal of Integrated Engineering

DOI: https://doi.org/10.30880/ijie.2018.10.09.029

Paper Response surface optimization for efficient dye removal by isolated strain Pseudomonas sp.

S. Senthilkumar; M. Perumalsamy; Harinarayan Janardhana Prabhuy et al. · 2012 · DOI

Full title: Response surface optimization for efficient dye removal by isolated strain Pseudomonas sp.

Authors: S. Senthilkumar; M. Perumalsamy; Harinarayan Janardhana Prabhuy; Chiya AhmedBasha; N. Anantharaman

Year: 2012

DOI: https://doi.org/10.2478/s13531-012-0001-9

Paper Produksi Kitosan Berbasis Limbah Udang Delta Mahakam : Tinjauan Proses Deasetilasi

Z. Arifin; Dedy Irawan; Marinda Rahim et al. · 2016 · DOI

Full title: Produksi Kitosan Berbasis Limbah Udang Delta Mahakam : Tinjauan Proses Deasetilasi

Authors: Z. Arifin; Dedy Irawan; Marinda Rahim; Lalang Dwiyoga Sakti

Year: 2016

DOI: https://doi.org/10.26578/jrti.v6i11.1504

Paper Formulation optimization of transdermal meloxicam potassium-loaded mesomorphic phases containing ethanol, oleic acid and mixture surfactant using the statistical experimental design methodology.

Huang, Chi-Te; Tsai, Chia-Hsun; Tsou, Hsin-Yeh et al. · 2011 · Journal of microencapsulation · DOI

Full title: Formulation optimization of transdermal meloxicam potassium-loaded mesomorphic phases containing ethanol, oleic acid and mixture surfactant using the statistical experimental design methodology.

Authors: Huang, Chi-Te; Tsai, Chia-Hsun; Tsou, Hsin-Yeh; Huang, Yaw-Bin; Tsai, Yi-Hung; Wu, Pao-Chu

Year: 2011

Venue: Journal of microencapsulation

DOI: https://doi.org/10.3109/02652048.2011.590611

Paper Approach to design space from retrospective quality data.

Puñal Peces, Daniel; García-Montoya, Encarna; Manich, Albert et al. · 2016 · Pharmaceutical development and technology · DOI

Full title: Approach to design space from retrospective quality data.

Authors: Puñal Peces, Daniel; García-Montoya, Encarna; Manich, Albert; Suñé-Negre, Josep Maria; Pérez-Lozano, Pilar; Miñarro, Montse; Ticó, Josep Ramon

Year: 2016

Venue: Pharmaceutical development and technology

DOI: https://doi.org/10.3109/10837450.2014.965321

Paper The use of response surface methodology in the evaluation of captopril microparticles manufactured using an oil in oil solvent evaporation technique.

Khamanga, Sandile Maswazi; Walker, Roderick B · 2012 · Journal of microencapsulation · DOI

Full title: The use of response surface methodology in the evaluation of captopril microparticles manufactured using an oil in oil solvent evaporation technique.

Authors: Khamanga, Sandile Maswazi; Walker, Roderick B

Year: 2012

Venue: Journal of microencapsulation

DOI: https://doi.org/10.3109/02652048.2011.629744

Paper A design of experiments to optimize a new manufacturing process for high activity protein-containing submicron particles.

Morales, Javier O; Joks, Gero M; Lamprecht, Alf et al. · 2013 · Drug development and industrial pharmacy · DOI

Full title: A design of experiments to optimize a new manufacturing process for high activity protein-containing submicron particles.

Authors: Morales, Javier O; Joks, Gero M; Lamprecht, Alf; Ross, Alistair C; McConville, Jason T

Year: 2013

Venue: Drug development and industrial pharmacy

DOI: https://doi.org/10.3109/03639045.2012.737332

Paper Novel method to construct large-scale design space in lubrication process utilizing Bayesian estimation based on a small-scale design-of-experiment and small sets of large-scale manufacturing data.

Maeda, Jin; Suzuki, Tatsuya; Takayama, Kozo · 2012 · Drug development and industrial pharmacy · DOI

Full title: Novel method to construct large-scale design space in lubrication process utilizing Bayesian estimation based on a small-scale design-of-experiment and small sets of large-scale manufacturing data.

Authors: Maeda, Jin; Suzuki, Tatsuya; Takayama, Kozo

Year: 2012

Venue: Drug development and industrial pharmacy

DOI: https://doi.org/10.3109/03639045.2011.653790

Paper Media milling process optimization for manufacture of drug nanoparticles using design of experiments (DOE).

Nekkanti, Vijaykumar; Marwah, Ashwani; Pillai, Raviraj · 2015 · Drug development and industrial pharmacy · DOI

Full title: Media milling process optimization for manufacture of drug nanoparticles using design of experiments (DOE).

Authors: Nekkanti, Vijaykumar; Marwah, Ashwani; Pillai, Raviraj

Year: 2015

Venue: Drug development and industrial pharmacy

DOI: https://doi.org/10.3109/03639045.2013.850709

Paper Use of central composite design in food microbiology: a case study on the effects of secondary phenols on lactic acid bacteria from olives.

Speranza, Barbara; Racioppo, Angela; Sinigaglia, Milena et al. · 2015 · International journal of food sciences and nutrition · DOI

Full title: Use of central composite design in food microbiology: a case study on the effects of secondary phenols on lactic acid bacteria from olives.

Authors: Speranza, Barbara; Racioppo, Angela; Sinigaglia, Milena; Corbo, Maria Rosaria; Bevilacqua, Antonio

Year: 2015

Venue: International journal of food sciences and nutrition

DOI: https://doi.org/10.3109/09637486.2015.1064866

Paper Quality by design approach in the optimization of the spray-drying process.

Baldinger, Arnaud; Clerdent, Lucas; Rantanen, Jukka et al. · 2012 · Pharmaceutical development and technology · DOI

Full title: Quality by design approach in the optimization of the spray-drying process.

Authors: Baldinger, Arnaud; Clerdent, Lucas; Rantanen, Jukka; Yang, Mingshi; Grohganz, Holger

Year: 2012

Venue: Pharmaceutical development and technology

DOI: https://doi.org/10.3109/10837450.2010.550623

Paper Quality by design approach: antioxidant activity of the tablets containing cornelian cherry fruits in relation to their composition and physical properties.

Kurhajec, Slavomír; Franc, Aleš; Doležel, Petr et al. · 2017 · Pharmaceutical development and technology · DOI

Full title: Quality by design approach: antioxidant activity of the tablets containing cornelian cherry fruits in relation to their composition and physical properties.

Authors: Kurhajec, Slavomír; Franc, Aleš; Doležel, Petr; Sabadková, Dana

Year: 2017

Venue: Pharmaceutical development and technology

DOI: https://doi.org/10.3109/10837450.2015.1135345

Paper Effect of simulated precompression, compression pressure and tableting speed on an offline diffuse transmittance and reflectance near-infrared spectral information of model intact caffeine tablets.

Vranic, Branko Z; Vandamme, Thierry F · 2015 · Pharmaceutical development and technology · DOI

Full title: Effect of simulated precompression, compression pressure and tableting speed on an offline diffuse transmittance and reflectance near-infrared spectral information of model intact caffeine tablets.

Authors: Vranic, Branko Z; Vandamme, Thierry F

Year: 2015

Venue: Pharmaceutical development and technology

DOI: https://doi.org/10.3109/10837450.2014.949267

Paper A supermartingale approach to Gaussian process based sequential design of experiments

Bect, Julien; Bachoc, François; Ginsbourger, David · 2019 · Bernoulli · DOI

Full title: A supermartingale approach to Gaussian process based sequential design of experiments

Authors: Bect, Julien; Bachoc, François; Ginsbourger, David

Year: 2019

Venue: Bernoulli

DOI: https://doi.org/10.3150/18-bej1074

Paper The Optimization of Sodium Tripolyphosphate Treatment Conditions on the Weight of Giant Freshwater Prawns (Macrobrachium rosenbergii) during Frozen Processing

Thuy Cao Xuan; A. Hong · 2025 · Preventive Nutrition and Food Science · DOI

Full title: The Optimization of Sodium Tripolyphosphate Treatment Conditions on the Weight of Giant Freshwater Prawns (Macrobrachium rosenbergii) during Frozen Processing

Authors: Thuy Cao Xuan; A. Hong

Year: 2025

Venue: Preventive Nutrition and Food Science

DOI: https://doi.org/10.3746/pnf.2025.30.2.177

Paper Characterization of complex systems using the design of experiments approach: transient protein expression in tobacco as a case study.

Buyel, Johannes Felix; Fischer, Rainer · 2014 · Journal of visualized experiments : JoVE · DOI

Full title: Characterization of complex systems using the design of experiments approach: transient protein expression in tobacco as a case study.

Authors: Buyel, Johannes Felix; Fischer, Rainer

Year: 2014

Venue: Journal of visualized experiments : JoVE

DOI: https://doi.org/10.3791/51216

Paper Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology.

Hemmerich, Johannes; Freier, Lars; Wiechert, Wolfgang et al. · 2017 · Journal of visualized experiments : JoVE · DOI

Full title: Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology.

Authors: Hemmerich, Johannes; Freier, Lars; Wiechert, Wolfgang; von Lieres, Eric; Oldiges, Marco

Year: 2017

Venue: Journal of visualized experiments : JoVE

DOI: https://doi.org/10.3791/56234

Paper Low-cost cultivation and sporulation of alkaliphilic Bacillus sp. strain AK13 for self-healing concrete.

Hong, Minyoung; Kim, Wonjae; Park, Woojun · 2019 · Journal of microbiology and biotechnology · DOI

Full title: Low-cost cultivation and sporulation of alkaliphilic Bacillus sp. strain AK13 for self-healing concrete.

Authors: Hong, Minyoung; Kim, Wonjae; Park, Woojun

Year: 2019

Venue: Journal of microbiology and biotechnology

DOI: https://doi.org/10.4014/jmb.1908.08034

Paper Chemo-Metric Optimization for Robust and Green Chromatographic Methods

F. O. Osabuohien · 2025 · International Journal of Innovative Science and Research Technology · DOI

Full title: Chemo-Metric Optimization for Robust and Green Chromatographic Methods

Authors: F. O. Osabuohien

Year: 2025

Venue: International Journal of Innovative Science and Research Technology

DOI: https://doi.org/10.38124/ijisrt/25oct1325

Paper A practical approach to automate randomized design of experiments for ligand-binding assays.

Tsoi, Jennifer; Patel, Vimal; Shih, Judy · 2014 · Bioanalysis · DOI

Full title: A practical approach to automate randomized design of experiments for ligand-binding assays.

Authors: Tsoi, Jennifer; Patel, Vimal; Shih, Judy

Year: 2014

Venue: Bioanalysis

DOI: https://doi.org/10.4155/bio.13.317

Paper Optimization ultrasonic-microwave-assisted extraction of phenolic compounds from Clinacanthus nutans using response surface methodology.

Chamutpong, Siriphatr; Chen, Chung-Jen; Chaiprateep, Em-On · 2021 · Journal of advanced pharmaceutical technology & research · DOI

Full title: Optimization ultrasonic-microwave-assisted extraction of phenolic compounds from Clinacanthus nutans using response surface methodology.

Authors: Chamutpong, Siriphatr; Chen, Chung-Jen; Chaiprateep, Em-On

Year: 2021

Venue: Journal of advanced pharmaceutical technology & research

DOI: https://doi.org/10.4103/japtr.JAPTR_344_20

Paper Development of response surface methodology for optimization of extraction parameters and quantitative estimation of embelin from Embelia ribes Burm by high performance liquid chromatography

Md. Shamsir Alam; Z. Damanhouri; Aftab Ahmad et al. · 2015 · Pharmacognosy Magazine · DOI

Full title: Development of response surface methodology for optimization of extraction parameters and quantitative estimation of embelin from Embelia ribes Burm by high performance liquid chromatography

Authors: Md. Shamsir Alam; Z. Damanhouri; Aftab Ahmad; L. Abidin; M. Amir; M. Aqil; Shahalam Khan; M. Mujeeb

Year: 2015

Venue: Pharmacognosy Magazine

DOI: https://doi.org/10.4103/0973-1296.157722

Paper Processing heterogeneous biomass: overcoming the hurdles in model building.

Buyel, Johannes F; Fischer, Rainer · 2013 · Bioengineered · DOI

Full title: Processing heterogeneous biomass: overcoming the hurdles in model building.

Authors: Buyel, Johannes F; Fischer, Rainer

Year: 2013

Venue: Bioengineered

DOI: https://doi.org/10.4161/bioe.21671

Paper Response surface methodology and process optimization of sustained release pellets using Taguchi orthogonal array design and central composite design.

Singh, Gurinder; Pai, Roopa S; Devi, V Kusum · 2012 · Journal of advanced pharmaceutical technology & research · DOI

Full title: Response surface methodology and process optimization of sustained release pellets using Taguchi orthogonal array design and central composite design.

Authors: Singh, Gurinder; Pai, Roopa S; Devi, V Kusum

Year: 2012

Venue: Journal of advanced pharmaceutical technology & research

DOI: https://doi.org/10.4103/2231-4040.93565

Paper Optimizing the Pomelo Oils Extraction Process by Microwave-Assisted Hydro-Distillation Using Soft Computing Approaches

T. T. Hien; Nguyen Phu Thuong Nhan; T. Nguyen et al. · 2018 · Solid State Phenomena · DOI

Full title: Optimizing the Pomelo Oils Extraction Process by Microwave-Assisted Hydro-Distillation Using Soft Computing Approaches

Authors: T. T. Hien; Nguyen Phu Thuong Nhan; T. Nguyen; V. T. T. Ho; L. Bach

Year: 2018

Venue: Solid State Phenomena

DOI: https://doi.org/10.4028/www.scientific.net/ssp.279.217

Paper Metronidazole adsorption on CoFe2O4/activated carbon@chitosan as a new magnetic biocomposite: modelling, analysis, and optimization by response surface methodology

Mohammad Malakootian; Alireza Nasiri; H. Mahdizadeh · 2019 · Desalination and Water Treatment · DOI

Full title: Metronidazole adsorption on CoFe2O4/activated carbon@chitosan as a new magnetic biocomposite: modelling, analysis, and optimization by response surface methodology

Authors: Mohammad Malakootian; Alireza Nasiri; H. Mahdizadeh

Year: 2019

Venue: Desalination and Water Treatment

DOI: https://doi.org/10.5004/dwt.2019.24433

Paper Utilizing design of experiments to characterize assay robustness.

Cowan, Kyra J; Erickson, Rich; Sue, Brian et al. · 2012 · Bioanalysis · DOI

Full title: Utilizing design of experiments to characterize assay robustness.

Authors: Cowan, Kyra J; Erickson, Rich; Sue, Brian; Delarosa, Reginald; Gunter, Bert; Coleman, Daniel A; Gilbert, Houston; Song, An; Fischer, Saloumeh Kadkhodayan

Year: 2012

Venue: Bioanalysis

DOI: https://doi.org/10.4155/bio.12.199

Paper The Use of Response Surface Methodology as a Statistical Tool for Media Optimization in Lipase Production from the Dairy Effluent Isolate Fusarium solani.

Kanmani, P; Karthik, S; Aravind, J et al. · 2013 · ISRN biotechnology · DOI

Full title: The Use of Response Surface Methodology as a Statistical Tool for Media Optimization in Lipase Production from the Dairy Effluent Isolate Fusarium solani.

Authors: Kanmani, P; Karthik, S; Aravind, J; Kumaresan, K

Year: 2013

Venue: ISRN biotechnology

DOI: https://doi.org/10.5402/2013/528708

Paper Mathematical Modelling as a Tool to Optimize PHA Production by Massilia spp

Priyanka Naik; Vaijayanti Ranade · 2020 · DOI

Full title: Mathematical Modelling as a Tool to Optimize PHA Production by Massilia spp

Authors: Priyanka Naik; Vaijayanti Ranade

Year: 2020

DOI: https://doi.org/10.9734/jabb/2020/v23i230140

Paper Approaches in Sequential Design of Experiments

Chernoff, Herman · 1973

Full title: Approaches in Sequential Design of Experiments

Authors: Chernoff, Herman

Year: 1973

Paper Improvement of one factor at a time through design of experiments

Wahid, Zaharah; Nadir, Najiah · 2012

Full title: Improvement of one factor at a time through design of experiments

Authors: Wahid, Zaharah; Nadir, Najiah

Year: 2012

Paper Enzyme-assisted purification of denatured atelocollagen, using pronase as scavenging agent.

Maier, S S; Maier, Vasilica; Popa, M et al. · 2010 · Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi

Full title: Enzyme-assisted purification of denatured atelocollagen, using pronase as scavenging agent.

Authors: Maier, S S; Maier, Vasilica; Popa, M; Ignat, Cristina Mihaela

Year: 2010

Venue: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi

Paper Enhanced Production of Insulin-like Growth Factor I Protein in Escherichia coli by Optimization of Five Key Factors.

Ranjbari, Javad; Babaeipour, Valiollah; Vahidi, Hossein et al. · 2015 · Iranian journal of pharmaceutical research : IJPR

Full title: Enhanced Production of Insulin-like Growth Factor I Protein in Escherichia coli by Optimization of Five Key Factors.

Authors: Ranjbari, Javad; Babaeipour, Valiollah; Vahidi, Hossein; Moghimi, Hamidreza; Mofid, Mohammad Reza; Namvaran, Mohammad Mehdi; Jafari, Sevda

Year: 2015

Venue: Iranian journal of pharmaceutical research : IJPR

Paper Optimization of lactic acid production in SSF by Lactobacillus amylovorus NRRL B-4542 using Taguchi methodology.

Nagarjun, Pyde Acharya; Rao, Ravella Sreenivas; Rajesham, Swargam et al. · 2005 · Journal of microbiology (Seoul, Korea)

Full title: Optimization of lactic acid production in SSF by Lactobacillus amylovorus NRRL B-4542 using Taguchi methodology.

Authors: Nagarjun, Pyde Acharya; Rao, Ravella Sreenivas; Rajesham, Swargam; Rao, Linga Venkateswar

Year: 2005

Venue: Journal of microbiology (Seoul, Korea)

Paper Optimization of Effective Minerals on Riboflavin Production by Bacillus subtilis subsp. subtilis ATCC 6051 Using Statistical Designs.

Oraei, Marjan; Razavi, Seyed Hadi; Khodaiyan, Faramarz · 2018 · Avicenna journal of medical biotechnology

Full title: Optimization of Effective Minerals on Riboflavin Production by Bacillus subtilis subsp. subtilis ATCC 6051 Using Statistical Designs.

Authors: Oraei, Marjan; Razavi, Seyed Hadi; Khodaiyan, Faramarz

Year: 2018

Venue: Avicenna journal of medical biotechnology

Paper Optimization of Growth Conditions of Lentinus edodes Mycelium and Polysaccharides on Walnut Shell by-Products Using Response Surface Analysis.

Ameri Shah Reza, Mahdieh; Vahidi, Hossein; Kobarfard, Farzad · 2018 · Iranian journal of pharmaceutical research : IJPR

Full title: Optimization of Growth Conditions of Lentinus edodes Mycelium and Polysaccharides on Walnut Shell by-Products Using Response Surface Analysis.

Authors: Ameri Shah Reza, Mahdieh; Vahidi, Hossein; Kobarfard, Farzad

Year: 2018

Venue: Iranian journal of pharmaceutical research : IJPR

Paper Preparation of a low-cost minimal medium for engineered Escherichia coli with high yield of human-like collagen II.

Luo, Yan'e; Mu, Tingzhen · 2014 · Pakistan journal of pharmaceutical sciences

Full title: Preparation of a low-cost minimal medium for engineered Escherichia coli with high yield of human-like collagen II.

Authors: Luo, Yan'e; Mu, Tingzhen

Year: 2014

Venue: Pakistan journal of pharmaceutical sciences

Paper Sampling Strategies for Computer Experiments: Design and Analysis

Simpson, Timothy W.; Dennis, Louise A.; Chen, W. · 2001

Full title: Sampling Strategies for Computer Experiments: Design and Analysis

Authors: Simpson, Timothy W.; Dennis, Louise A.; Chen, W.

Year: 2001

Paper Study of Optimality Criteria in Design of Experiments.

Hedayat, A. · 1980 · Defense Technical Information Center (DTIC)

Full title: Study of Optimality Criteria in Design of Experiments.

Authors: Hedayat, A.

Year: 1980

Venue: Defense Technical Information Center (DTIC)

Paper Use of Taguchi methodology to enhance the yield of caffeine removal with growing cultures of Pseudomonas pseudoalcaligenes.

Ashengroph, Morahem; Ababaf, Sajad · 2014 · Iranian journal of microbiology

Full title: Use of Taguchi methodology to enhance the yield of caffeine removal with growing cultures of Pseudomonas pseudoalcaligenes.

Authors: Ashengroph, Morahem; Ababaf, Sajad

Year: 2014

Venue: Iranian journal of microbiology

Thesis A Bayesian Perspective on Factorial Experiments Using Potential Outcomes

Espinosa, Valeria · 2014 · Harvard University - DASH · DOI

Full title: A Bayesian Perspective on Factorial Experiments Using Potential Outcomes

Authors: Espinosa, Valeria

Year: 2014

Venue: Harvard University - DASH

DOI: http://dissertations.umi.com/gsas.harvard:11245

Thesis A Systematic Framework to Optimize and Control Monoclonal Antibody Manufacturing Process

Li, Ying Fei · 2018 · Columbia University · DOI

Full title: A Systematic Framework to Optimize and Control Monoclonal Antibody Manufacturing Process

Authors: Li, Ying Fei

Year: 2018

Venue: Columbia University

DOI: https://doi.org/10.7916/D8GX5TJP

Thesis Rational design of a scalable bioprocess platform for bacterial cellulose production

Basu, Anindya; Vadanan, Sundaravadanam Vishnu; Lim, Sierin · 2020 · Nanyang Technological University (NTU) · DOI

Full title: Rational design of a scalable bioprocess platform for bacterial cellulose production

Authors: Basu, Anindya; Vadanan, Sundaravadanam Vishnu; Lim, Sierin

Year: 2020

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/143693

Thesis Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Zhang, Liang · 2020 · KTH Royal Institute of Technology · DOI

Full title: Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Authors: Zhang, Liang

Year: 2020

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-273343

Thesis Design of experiment approach to leukemia studies

Tan, Jeremy Zhi Qiang. · 2011 · Nanyang Technological University (NTU) · DOI

Full title: Design of experiment approach to leukemia studies

Authors: Tan, Jeremy Zhi Qiang.

Year: 2011

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/42795

Thesis Global optimization of cis-cyclooctene with very few experiments

Ong, Woo Ren. · 2010 · Nanyang Technological University (NTU) · DOI

Full title: Global optimization of cis-cyclooctene with very few experiments

Authors: Ong, Woo Ren.

Year: 2010

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/39677

Thesis Optimal replicates for designed experiments under the online framework

Sudarsanam, Nandan; Pitchai Kannu, Balaji; Frey, Daniel D · 2021 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Optimal replicates for designed experiments under the online framework

Authors: Sudarsanam, Nandan; Pitchai Kannu, Balaji; Frey, Daniel D

Year: 2021

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/131804

Thesis A statistical methodology to optimise soluble production of virus-like particle protein by fermentation of Escherichia coli

Huynh, Nhat Hoang · 2021 · University of Adelaide · DOI

Full title: A statistical methodology to optimise soluble production of virus-like particle protein by fermentation of Escherichia coli

Authors: Huynh, Nhat Hoang

Year: 2021

Venue: University of Adelaide

DOI: http://hdl.handle.net/2440/130731

Thesis Towards open-source optimisation for bespoke cell-free protein synthesis systems

Perkins, Alex · 2025 · The University of Edinburgh · DOI

Full title: Towards open-source optimisation for bespoke cell-free protein synthesis systems

Authors: Perkins, Alex

Year: 2025

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/43747

Thesis Morphology optimization of ordered chromatography stationary phases: a workflow designed by machine learning and computational fluid dynamics

Jiang, Qihao · 2023 · The University of Edinburgh · DOI

Full title: Morphology optimization of ordered chromatography stationary phases: a workflow designed by machine learning and computational fluid dynamics

Authors: Jiang, Qihao

Year: 2023

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/39694

Thesis In situ recovery of the anticancer drug “paclitaxel” and its precursors from engineered yeast and plant cells using different macro-porous resins

Santoyo-Garcia, Jorge Humberto · 2023 · The University of Edinburgh · DOI

Full title: In situ recovery of the anticancer drug “paclitaxel” and its precursors from engineered yeast and plant cells using different macro-porous resins

Authors: Santoyo-Garcia, Jorge Humberto

Year: 2023

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/40497

Thesis New Cost-Effective Medium Formulation for 1,3-Propanediol Production in Fermentation Process

Zhu, Jin · 2025 · University of Saskatchewan - HARVEST · DOI

Full title: New Cost-Effective Medium Formulation for 1,3-Propanediol Production in Fermentation Process

Authors: Zhu, Jin

Year: 2025

Venue: University of Saskatchewan - HARVEST

DOI: https://hdl.handle.net/10388/17144

Thesis Shape constrained splines as transparent black-box models for bioprocess modeling

Masic, Alma; Srinivasan, Sriniketh; Billeter, Julien et al. · 2017 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Shape constrained splines as transparent black-box models for bioprocess modeling

Authors: Masic, Alma; Srinivasan, Sriniketh; Billeter, Julien; Bonvin, Dominique; Villez, Kris

Year: 2017

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/136969

Thesis Development and validation of a hybrid model for prediction of viable cell density, titer and cumulative glucose consumption in a mammalian cell culture system

Yatipanthalawa, BS; Wallace Fitzsimons, SE; Horning, T et al. · 2024 · University of Melbourne · DOI

Full title: Development and validation of a hybrid model for prediction of viable cell density, titer and cumulative glucose consumption in a mammalian cell culture system

Authors: Yatipanthalawa, BS; Wallace Fitzsimons, SE; Horning, T; Lee, YY; Gras, SL

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/345116

Thesis Capturing uncertainty in black-box chromatography modelling using conformal prediction and Gaussian processes

Pham, TD; Bassett, R; Aickelin, U · 2025 · University of Melbourne · DOI

Full title: Capturing uncertainty in black-box chromatography modelling using conformal prediction and Gaussian processes

Authors: Pham, TD; Bassett, R; Aickelin, U

Year: 2025

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/356460

Thesis Single-objective robust optimisation in bioprocessing with conformalised quantile regression as interval-based surrogate models

Pham, TD; Bassett, R; Aickelin, U · 2025 · University of Melbourne · DOI

Full title: Single-objective robust optimisation in bioprocessing with conformalised quantile regression as interval-based surrogate models

Authors: Pham, TD; Bassett, R; Aickelin, U

Year: 2025

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/361033

Thesis BRIDGING EXPERIMENTAL AND IN-SILICO METHODS FOR ADVANCED MAMMALIAN BIOMANUFACTURING OPTIMIZATION

Ndahiro, Nelson · 2025 · Johns Hopkins University · DOI

Full title: BRIDGING EXPERIMENTAL AND IN-SILICO METHODS FOR ADVANCED MAMMALIAN BIOMANUFACTURING OPTIMIZATION

Authors: Ndahiro, Nelson

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70287

Thesis Engineering oleaginous yeasts for a bio-based future

Duman-Özdamar, Zeynep Efsun · 2025 · Wageningen University & Research · DOI

Full title: Engineering oleaginous yeasts for a bio-based future

Authors: Duman-Özdamar, Zeynep Efsun

Year: 2025

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/engineering-oleaginous-yeasts-for-a-bio-based-future

Thesis Influence of non-linearity to the Optimal Experimental Design demonstrated by a biological system

R. Schenkendorf; A. Kremling; M. Mangold · 2012 · Technical University of Munich (TUM) · DOI

Full title: Influence of non-linearity to the Optimal Experimental Design demonstrated by a biological system

Authors: R. Schenkendorf; A. Kremling; M. Mangold

Year: 2012

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1129679

Thesis Evaluation and optimization of hepatocyte culture media factors by design of experiments (DoE) methodology.

Dong, J; Mandenius, CF; Lübberstedt, M et al. · 2008 · Technical University of Munich (TUM) · DOI

Full title: Evaluation and optimization of hepatocyte culture media factors by design of experiments (DoE) methodology.

Authors: Dong, J;Mandenius, CF;Lübberstedt, M;Urbaniak, T;Nüssler, AK;Knobeloch, D;Gerlach, JC;Zeilinger, K

Year: 2008

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1589764

Thesis Optimization of batch adsorption and fixed-bed adsorption of vanillin onto resin H103

Abu Samah, Rozaimi · 2016 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Optimization of batch adsorption and fixed-bed adsorption of vanillin onto resin H103

Authors: Abu Samah, Rozaimi

Year: 2016

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/69039/7/FBSB%202016%2022%20-%20IR%20edit.pdf

Thesis Effect of backwash as a strategy for biofouling control in the submerged ceramic membrane bioreactor for high-density cultivations: Process optimization and fouling mechanism at pilot scale

Jankowska, Katarzyna; id_orcid 0000-0002-3283-0338; Domingo-Félez, Carlos et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Effect of backwash as a strategy for biofouling control in the submerged ceramic membrane bioreactor for high-density cultivations: Process optimization and fouling mechanism at pilot scale

Authors: Jankowska, Katarzyna; id_orcid 0000-0002-3283-0338; Domingo-Félez, Carlos; Andres Prado-Rubio, Oscar; Skiadas, Ioannis V.; id_orcid 0000-0001-6183-4592; Woodley, John M.; id_orcid 0000-0002-7976-2483; Pinelo, Manuel; id_orcid 0000-0002-3944-6144

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/05202080-96c1-4cd4-90a7-6e5acc14bcd3

Thesis Enhancing Saccharomyces cerevisiae Taxane Biosynthesis and Overcoming Nutritional Stress-Induced Pseudohyphal Growth

Walls, Laura Ellen; Martinez, José L; id_orcid 0000-0002-4490-8534 et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Enhancing Saccharomyces cerevisiae Taxane Biosynthesis and Overcoming Nutritional Stress-Induced Pseudohyphal Growth

Authors: Walls, Laura Ellen; Martinez, José L; id_orcid 0000-0002-4490-8534; Rios-Solis, Leonardo

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1fe5f10e-3e62-4344-8fce-daaef23aba9a

Thesis Incorporating first-principles information into hybrid modeling structures:Comparing hybrid semi-parametric models with Physics-Informed Recurrent Neural Networks

Jul-Rasmussen, Peter; Kumar, Monesh; Pinto, Jóse et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Incorporating first-principles information into hybrid modeling structures:Comparing hybrid semi-parametric models with Physics-Informed Recurrent Neural Networks

Authors: Jul-Rasmussen, Peter; Kumar, Monesh; Pinto, Jóse; Oliveira, Rui; Liang, Xiaodong; id_orcid 0000-0002-2007-546X; Huusom, Jakob Kjøbsted; id_orcid 0000-0002-1367-7235

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2dd517a0-a669-45bb-80c5-0f8a809c6d99

Thesis Hybrid machine-learning for dynamic plant-wide biomanufacturing

Shahhoseyni, Shabnam; Chakraborty, Arijit; Boskabadi, Mohammad Reza et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Hybrid machine-learning for dynamic plant-wide biomanufacturing

Authors: Shahhoseyni, Shabnam; Chakraborty, Arijit; Boskabadi, Mohammad Reza; Venkatasubramanian, Venkat; Mansouri, Seyed Soheil; id_orcid 0000-0002-0924-4947

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/31b83b7d-b842-484f-9d03-65c948d398c6

Thesis Automating Experimentation in Miniaturized Reactors

Tajsoleiman, Tannaz; id_orcid 0000-0001-8543-4585 · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Automating Experimentation in Miniaturized Reactors

Authors: Tajsoleiman, Tannaz; id_orcid 0000-0001-8543-4585

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/386087d5-5f25-4e66-b07f-92ac36e0e80c

Thesis Definitive screening accelerates Taxol biosynthetic pathway optimization and scale up in Saccharomyces cerevisiae cell factories

Walls, Laura E.; Martinez, José L.; id_orcid 0000-0002-4490-8534 et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Definitive screening accelerates Taxol biosynthetic pathway optimization and scale up in Saccharomyces cerevisiae cell factories

Authors: Walls, Laura E.; Martinez, José L.; id_orcid 0000-0002-4490-8534; Antonio Del Rio Chanona, E.; Rios-Solis, Leonardo

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/33838982-049a-4ae6-a09c-d725e9b38afd

Thesis Dynamics of batch protein precipitation

Ehtesham, Amirkiarash; Sivaram, Abhishek; Siegel, Sara Danielle et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Dynamics of batch protein precipitation

Authors: Ehtesham, Amirkiarash; Sivaram, Abhishek; Siegel, Sara Danielle; Zanten, John van; Mansouri, Seyed Soheil; id_orcid 0000-0002-0924-4947

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/56926f26-9ec2-40d5-ac91-1efcabb0e012

Thesis Implementation of real-time incremental learning for ensemble hybrid model prediction in pilot scale bubble column aeration

Jul-Rasmussen, Peter; Stevnsborg, Mads; Liang, Xiaodong et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Implementation of real-time incremental learning for ensemble hybrid model prediction in pilot scale bubble column aeration

Authors: Jul-Rasmussen, Peter; Stevnsborg, Mads; Liang, Xiaodong; id_orcid 0000-0002-2007-546X; Huusom, Jakob Kjøbsted; id_orcid 0000-0002-1367-7235

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3a281c09-30fc-4659-9dc6-33d64f78b7b8

Thesis Advanced modeling of industrial-scale fermentation process for antibiotic production

Magnusson, Atli Freyr; id_orcid 0000-0003-4060-2965 · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Advanced modeling of industrial-scale fermentation process for antibiotic production

Authors: Magnusson, Atli Freyr; id_orcid 0000-0003-4060-2965

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5ec6b30f-579e-465d-b28a-5223114e5c8d

Thesis Artificial intelligence approach for high level production of amylase using Rhizopus microsporus var. oligosporus and different agro-industrial wastes

Fernandez Nunez, Eutimio Gustavo [UNESP]; Barchi, Augusto Cesar [UNESP]; Ito, Shuri [UNESP] et al. · 2018 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Artificial intelligence approach for high level production of amylase using Rhizopus microsporus var. oligosporus and different agro-industrial wastes

Authors: Fernandez Nunez, Eutimio Gustavo [UNESP]; Barchi, Augusto Cesar [UNESP]; Ito, Shuri [UNESP]; Escaramboni, Bruna [UNESP]; Herculano, Rondinelli Donizetti [UNESP]; Malacrida Mayer, Cassia Roberta [UNESP]; Neto, Pedro de Oliva [UNESP]

Year: 2018

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1002/jctb.5054

Thesis Study of influence of yeast cells treatment on sugarcane ethanol fermentation: Operating conditions and kinetics

Yamakawa, Celina Kiyomi; id_orcid 0000-0003-2394-0364; Ccopa Rivera, Elmer et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Study of influence of yeast cells treatment on sugarcane ethanol fermentation: Operating conditions and kinetics

Authors: Yamakawa, Celina Kiyomi; id_orcid 0000-0003-2394-0364; Ccopa Rivera, Elmer; Kwon, Hyun; Herrera Agudelo, William E.; Saad, Marcelo B.W.; Leal, Jairo; Rossell, Carlos E.V.; Bonomi, Antonio; Maciel Filho, Rubens

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5e82eae1-8c60-4aeb-8ccc-570e995a08f8

Thesis A simple yet powerful hybrid machine learning approach to aid decision-making in laboratory experiments

Campos Diocaretz, Bernardo; Tűzesi, Ágota; Herdean, Andrei · 2025 · Charles Sturt University - Research Output · DOI

Full title: A simple yet powerful hybrid machine learning approach to aid decision-making in laboratory experiments

Authors: Campos Diocaretz, Bernardo; Tűzesi, Ágota; Herdean, Andrei

Year: 2025

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/7c932bde-e7a5-4f97-a6e4-0e1694f091df

Thesis Continuous ethanol production via ultrasound-enhanced yeast sedimentation

Domingo-Félez, Carlos; Jankowska, Katarzyna; id_orcid 0000-0002-3283-0338 et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Continuous ethanol production via ultrasound-enhanced yeast sedimentation

Authors: Domingo-Félez, Carlos; Jankowska, Katarzyna; id_orcid 0000-0002-3283-0338; Skiadas, Ioannis V.; id_orcid 0000-0001-6183-4592; Woodley, John M.; id_orcid 0000-0002-7976-2483; Pinelo, Manuel; id_orcid 0000-0002-3944-6144

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9dd0dd08-655a-429c-a5bc-6186023c6c6b

Thesis Unlocking DOE potential by selecting the most appropriate design for rAAV optimization

Tzimou, Konstantina; Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Unlocking DOE potential by selecting the most appropriate design for rAAV optimization

Authors: Tzimou, Konstantina; Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Nielsen, Lars K.; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bcce91f5-d977-47e8-a623-e02bd6425a16

Thesis Application of Iterative Robust Model-based Optimal Experimental Design for the Calibration of Biocatalytic Models

Van Daele, Timothy; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773 et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Application of Iterative Robust Model-based Optimal Experimental Design for the Calibration of Biocatalytic Models

Authors: Van Daele, Timothy; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Ringborg, Rolf Hoffmeyer; Börner, Tim; Heintz, Søren; Van Hauwermeiren, Daan; Grey, Carl; Krühne, Ulrich; id_orcid 0000-0001-7774-7442; Adlercreutz, Patrick; Nopens, Ingmar

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/cbf59af0-0a86-42ce-ba00-7f0bd72af61f

Thesis Hybrid Optimization Methods for Parameter Estimation of Reactive Transport Systems

Schytt, Marcus Johan; id_orcid 0009-0001-8143-1878; Pétursson, Halldór Gauti et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Hybrid Optimization Methods for Parameter Estimation of Reactive Transport Systems

Authors: Schytt, Marcus Johan; id_orcid 0009-0001-8143-1878; Pétursson, Halldór Gauti; Jørgensen, John Bagterp; id_orcid 0000-0001-9799-2808

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/cee4ce4c-3457-441a-889e-3a3e2ffdebe5

Thesis Modeling and Simulation of Upstream and Downstream Processes for Monoclonal Antibody Production

Wahlgreen, Morten Ryberg; Meyer, Kristian; Ritschel, Tobias K.S. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Modeling and Simulation of Upstream and Downstream Processes for Monoclonal Antibody Production

Authors: Wahlgreen, Morten Ryberg; Meyer, Kristian; Ritschel, Tobias K.S.; id_orcid 0000-0002-5843-240X; Engsig-Karup, Allan Peter; id_orcid 0000-0001-8626-1575; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Jørgensen, John Bagterp; id_orcid 0000-0001-9799-2808

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bee80c6c-737f-485c-a10c-8b202794086b

Thesis Optimizing protein-cell separation in submerged membrane bioreactor for clarification

Karki, Rebat; Skiadas, Ioannis V.; id_orcid 0000-0001-6183-4592 et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Optimizing protein-cell separation in submerged membrane bioreactor for clarification

Authors: Karki, Rebat; Skiadas, Ioannis V.; id_orcid 0000-0001-6183-4592; Woodley, John M.; id_orcid 0000-0002-7976-2483; Pinelo, Manuel; id_orcid 0000-0002-3944-6144

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d3e758c5-68ff-4a85-a40a-d984ecbacd53

Thesis Output uncertainty of dynamic growth models: Effect of uncertain parameter estimates on model reliability

Anane, Emmanuel; López C, Diana C.; Barz, Tilman et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Output uncertainty of dynamic growth models: Effect of uncertain parameter estimates on model reliability

Authors: Anane, Emmanuel; López C, Diana C.; Barz, Tilman; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Neubauer, Peter; Cruz Bournazou, Mariano Nicolas

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e2b40834-81af-4e34-9475-5a085aedbd5d

Thesis Effect of backwash as a strategy for biofouling control in the submerged ceramic membrane bioreactor for high-density cultivations: Process optimization and fouling mechanism at pilot scale

Jankowska, Katarzyna; id_orcid 0000-0002-3283-0338; Domingo-Félez, Carlos et al. · 2024 · Technical University of Denmark (DTU) · DOI

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/05202080-96c1-4cd4-90a7-6e5acc14bcd3

Thesis Novel strategies for control of fermentation processes

Mears, Lisa · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Novel strategies for control of fermentation processes

Authors: Mears, Lisa

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f0e5a504-744d-491b-be8f-d469c1d71bca

Thesis Targeting population heterogeneity for optimal cell factories

Heins, Anna-Lena; Carlqvist, Magnus; Helmark, S. et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: Targeting population heterogeneity for optimal cell factories

Authors: Heins, Anna-Lena; Carlqvist, Magnus; Helmark, S.; Lencastre Fernandes, Rita; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Eliasson Lantz, Anna

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f6330829-57ee-45a2-9c4a-1e6ef89fe66a

Thesis Model-based process development for a continuous lactic acid bacteria fermentation

Spann, Robert; id_orcid 0000-0003-1223-2805; Eliasson Lantz, Anna et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Model-based process development for a continuous lactic acid bacteria fermentation

Authors: Spann, Robert; id_orcid 0000-0003-1223-2805; Eliasson Lantz, Anna; Roca, Christophe; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Sin, Gürkan; id_orcid 0000-0003-0513-4502

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/160dc8f9-800f-435a-a363-07bd562c8c2d

Thesis Enhancing Saccharomyces cerevisiae Taxane Biosynthesis and Overcoming Nutritional Stress-Induced Pseudohyphal Growth

Walls, Laura Ellen; Martinez, José L; id_orcid 0000-0002-4490-8534 et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Enhancing Saccharomyces cerevisiae Taxane Biosynthesis and Overcoming Nutritional Stress-Induced Pseudohyphal Growth

Authors: Walls, Laura Ellen; Martinez, José L; id_orcid 0000-0002-4490-8534; Rios-Solis, Leonardo

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1fe5f10e-3e62-4344-8fce-daaef23aba9a

Thesis Definitive screening accelerates Taxol biosynthetic pathway optimization and scale up in Saccharomyces cerevisiae cell factories

Walls, Laura E.; Martinez, José L.; id_orcid 0000-0002-4490-8534 et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Definitive screening accelerates Taxol biosynthetic pathway optimization and scale up in Saccharomyces cerevisiae cell factories

Authors: Walls, Laura E.; Martinez, José L.; id_orcid 0000-0002-4490-8534; Antonio Del Rio Chanona, E.; Rios-Solis, Leonardo

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/33838982-049a-4ae6-a09c-d725e9b38afd

Thesis Hybrid machine-learning for dynamic plant-wide biomanufacturing

Shahhoseyni, Shabnam; Chakraborty, Arijit; Boskabadi, Mohammad Reza et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Hybrid machine-learning for dynamic plant-wide biomanufacturing

Authors: Shahhoseyni, Shabnam; Chakraborty, Arijit; Boskabadi, Mohammad Reza; Venkatasubramanian, Venkat; Mansouri, Seyed Soheil; id_orcid 0000-0002-0924-4947

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/31b83b7d-b842-484f-9d03-65c948d398c6

Thesis Automating Experimentation in Miniaturized Reactors

Tajsoleiman, Tannaz; id_orcid 0000-0001-8543-4585 · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Automating Experimentation in Miniaturized Reactors

Authors: Tajsoleiman, Tannaz; id_orcid 0000-0001-8543-4585

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/386087d5-5f25-4e66-b07f-92ac36e0e80c

Thesis Development, modelling, optimisation and scale-up of chromatographic purification of a therapeutic protein

Mollerup, Jørgen; Hansen, Thomas Budde; Kidal, Steffen et al. · 2007 · Technical University of Denmark (DTU) · DOI

Full title: Development, modelling, optimisation and scale-up of chromatographic purification of a therapeutic protein

Authors: Mollerup, Jørgen; Hansen, Thomas Budde; Kidal, Steffen; Sejergaard, Lars; Staby, Arne

Year: 2007

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4322cb55-ff05-44bb-a71a-65a9e5436acf

Thesis A “real‐time” sequential hybrid modeling approach to monitor and forecast key process variables in ethanol fermentation using lignocellulosic feedstocks

Lopez, Pau Cabañeros; Udugama, Isuru; Thomsen, Sune Tjalfe et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: A “real‐time” sequential hybrid modeling approach to monitor and forecast key process variables in ethanol fermentation using lignocellulosic feedstocks

Authors: Lopez, Pau Cabañeros; Udugama, Isuru; Thomsen, Sune Tjalfe; Roslander, Christian; Junicke, Helena; id_orcid 0000-0002-2513-2486; Mauricio-Iglesias, Miguel; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3a162256-b10e-48e0-89bf-1d67d41c02b3

Thesis An Efficient Experimental Design Strategy for Modelling and Characterization of Processes

Tajsoleiman, Tannaz; id_orcid 0000-0001-8543-4585; Semenova, Daria et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: An Efficient Experimental Design Strategy for Modelling and Characterization of Processes

Authors: Tajsoleiman, Tannaz; id_orcid 0000-0001-8543-4585; Semenova, Daria; Oliveira Fernandes, Ana Carolina; Huusom, Jakob Kjøbsted; id_orcid 0000-0002-1367-7235; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Krühne, Ulrich; id_orcid 0000-0001-7774-7442

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3eea6424-49d5-422a-b6f7-25ec9e7da0b8

Thesis Advanced modeling of industrial-scale fermentation process for antibiotic production

Magnusson, Atli Freyr; id_orcid 0000-0003-4060-2965 · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Advanced modeling of industrial-scale fermentation process for antibiotic production

Authors: Magnusson, Atli Freyr; id_orcid 0000-0003-4060-2965

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5ec6b30f-579e-465d-b28a-5223114e5c8d

Thesis A Method for Systematic Improvement of Stochastic Grey-Box Models

Kristensen, Niels Rode; Madsen, Henrik; id_orcid 0000-0003-0690-3713 et al. · 2004 · Technical University of Denmark (DTU) · DOI

Full title: A Method for Systematic Improvement of Stochastic Grey-Box Models

Authors: Kristensen, Niels Rode; Madsen, Henrik; id_orcid 0000-0003-0690-3713; Jørgensen, Sten Bay; id_orcid 0000-0002-3179-972X

Year: 2004

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/55695fc1-7d99-4173-8d94-51f9e06b3ec1

Thesis Dynamics of batch protein precipitation

Ehtesham, Amirkiarash; Sivaram, Abhishek; Siegel, Sara Danielle et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Dynamics of batch protein precipitation

Authors: Ehtesham, Amirkiarash; Sivaram, Abhishek; Siegel, Sara Danielle; Zanten, John van; Mansouri, Seyed Soheil; id_orcid 0000-0002-0924-4947

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/56926f26-9ec2-40d5-ac91-1efcabb0e012

Thesis Study of influence of yeast cells treatment on sugarcane ethanol fermentation: Operating conditions and kinetics

Yamakawa, Celina Kiyomi; id_orcid 0000-0003-2394-0364; Ccopa Rivera, Elmer et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Study of influence of yeast cells treatment on sugarcane ethanol fermentation: Operating conditions and kinetics

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5e82eae1-8c60-4aeb-8ccc-570e995a08f8

Thesis Functional Unfold Principal Component Regression Methodology for Analysis of Industrial Batch Process Data

Mears, Lisa; Nørregaard, Rasmus; Sin, Gürkan et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Functional Unfold Principal Component Regression Methodology for Analysis of Industrial Batch Process Data

Authors: Mears, Lisa; Nørregaard, Rasmus; Sin, Gürkan; id_orcid 0000-0003-0513-4502; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Stocks, Stuart M.; Albæk, Mads O.; Villez, Kris

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/78aedfe4-16d1-43ae-a383-cf55627b9c77

Thesis Targeting population heterogeneity in Saccharomyces cerevisiae batch fermentation for optimal cell factories

Heins, Anna-Lena; Lencastre Fernandes, Rita; Lundin, L. et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: Targeting population heterogeneity in Saccharomyces cerevisiae batch fermentation for optimal cell factories

Authors: Heins, Anna-Lena; Lencastre Fernandes, Rita; Lundin, L.; Carlqvist, Magnus; Sörensen, S.; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Eliasson Lantz, Anna

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/801e9683-53b1-45e0-b7d7-0909e8f633f4

Thesis A simple yet powerful hybrid machine learning approach to aid decision-making in laboratory experiments

Campos Diocaretz, Bernardo; Tűzesi, Ágota; Herdean, Andrei · 2025 · Charles Sturt University - Research Output · DOI

Full title: A simple yet powerful hybrid machine learning approach to aid decision-making in laboratory experiments

Authors: Campos Diocaretz, Bernardo; Tűzesi, Ágota; Herdean, Andrei

Year: 2025

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/7c932bde-e7a5-4f97-a6e4-0e1694f091df

Thesis Developing Phenomena Models from Experimental Data

Kristensen, Niels Rode; Madsen, H.; Jørgensen, Sten Bay et al. · 2003 · Technical University of Denmark (DTU) · DOI

Full title: Developing Phenomena Models from Experimental Data

Authors: Kristensen, Niels Rode; Madsen, H.; Jørgensen, Sten Bay; id_orcid 0000-0002-3179-972X

Year: 2003

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/8d2dac70-0f67-4b19-9c7a-3b3842167085

Thesis Continuous ethanol production via ultrasound-enhanced yeast sedimentation

Domingo-Félez, Carlos; Jankowska, Katarzyna; id_orcid 0000-0002-3283-0338 et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Continuous ethanol production via ultrasound-enhanced yeast sedimentation

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9dd0dd08-655a-429c-a5bc-6186023c6c6b

Thesis Comparison of spectroscopy technologies for improved monitoring of cell culture processes in miniature bioreactors

Rowland-Jones, Ruth C.; van der Berg, Franciscus Winfried J; Racher, Andrew J. et al. · 2017 · University of Copenhagen · DOI

Full title: Comparison of spectroscopy technologies for improved monitoring of cell culture processes in miniature bioreactors

Authors: Rowland-Jones, Ruth C.; van der Berg, Franciscus Winfried J; Racher, Andrew J.; Martin, Elaine B.; Jaques, Colin

Year: 2017

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/b0ba0d28-f1e5-4abb-be69-231b4094c928

Thesis Unlocking DOE potential by selecting the most appropriate design for rAAV optimization

Tzimou, Konstantina; Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Unlocking DOE potential by selecting the most appropriate design for rAAV optimization

Authors: Tzimou, Konstantina; Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Nielsen, Lars K.; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bcce91f5-d977-47e8-a623-e02bd6425a16

Thesis Modeling, design and simulation of intensified chromatography processes

Frandsen, Jesper · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Modeling, design and simulation of intensified chromatography processes

Authors: Frandsen, Jesper

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d1217e31-277e-4cd1-ab00-463f2ac2ac70

Thesis Application of Iterative Robust Model-based Optimal Experimental Design for the Calibration of Biocatalytic Models

Van Daele, Timothy; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773 et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Application of Iterative Robust Model-based Optimal Experimental Design for the Calibration of Biocatalytic Models

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/cbf59af0-0a86-42ce-ba00-7f0bd72af61f

Thesis Modeling and Simulation of Upstream and Downstream Processes for Monoclonal Antibody Production

Wahlgreen, Morten Ryberg; Meyer, Kristian; Ritschel, Tobias K.S. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Modeling and Simulation of Upstream and Downstream Processes for Monoclonal Antibody Production

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bee80c6c-737f-485c-a10c-8b202794086b

Thesis Hybrid Optimization Methods for Parameter Estimation of Reactive Transport Systems

Schytt, Marcus Johan; id_orcid 0009-0001-8143-1878; Pétursson, Halldór Gauti et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Hybrid Optimization Methods for Parameter Estimation of Reactive Transport Systems

Authors: Schytt, Marcus Johan; id_orcid 0009-0001-8143-1878; Pétursson, Halldór Gauti; Jørgensen, John Bagterp; id_orcid 0000-0001-9799-2808

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/cee4ce4c-3457-441a-889e-3a3e2ffdebe5

Thesis Output uncertainty of dynamic growth models: Effect of uncertain parameter estimates on model reliability

Anane, Emmanuel; López C, Diana C.; Barz, Tilman et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Output uncertainty of dynamic growth models: Effect of uncertain parameter estimates on model reliability

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e2b40834-81af-4e34-9475-5a085aedbd5d

Thesis Optimizing protein-cell separation in submerged membrane bioreactor for clarification

Karki, Rebat; Skiadas, Ioannis V.; id_orcid 0000-0001-6183-4592 et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Optimizing protein-cell separation in submerged membrane bioreactor for clarification

Authors: Karki, Rebat; Skiadas, Ioannis V.; id_orcid 0000-0001-6183-4592; Woodley, John M.; id_orcid 0000-0002-7976-2483; Pinelo, Manuel; id_orcid 0000-0002-3944-6144

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d3e758c5-68ff-4a85-a40a-d984ecbacd53

Thesis Model-based optimization of a recombinant E. coli fed-batch process for best time-space yield and conversion efficiency

Kager, Julian; id_orcid 0000-0001-7274-6678; Horst, Nora et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Model-based optimization of a recombinant E. coli fed-batch process for best time-space yield and conversion efficiency

Authors: Kager, Julian; id_orcid 0000-0001-7274-6678; Horst, Nora; Herwig, Christoph; Skiadas, Ioannis V.; id_orcid 0000-0001-6183-4592

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ede3ad48-f54e-44ca-ba10-d7fda23e5c9f

Thesis Targeting population heterogeneity for optimal cell factories

Heins, Anna-Lena; Carlqvist, Magnus; Helmark, S. et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: Targeting population heterogeneity for optimal cell factories

Authors: Heins, Anna-Lena; Carlqvist, Magnus; Helmark, S.; Lencastre Fernandes, Rita; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Eliasson Lantz, Anna

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f6330829-57ee-45a2-9c4a-1e6ef89fe66a

Thesis Novel strategies for control of fermentation processes

Mears, Lisa · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Novel strategies for control of fermentation processes

Authors: Mears, Lisa

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f0e5a504-744d-491b-be8f-d469c1d71bca

Thesis Use of uniform designs in combination with neural networks for viral infection process development

Buenno, Laís Hara; Rocha, José Celso; Leme, Jaci et al. · 2015 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Use of uniform designs in combination with neural networks for viral infection process development

Authors: Buenno, Laís Hara; Rocha, José Celso; Leme, Jaci; Caricati, Celso Pereira; Tonso, Aldo; Nuñez, Eutimio Gustavo Fernández [UNESP]

Year: 2015

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://onlinelibrary.wiley.com/doi/10.1002/btpr.2051/abstract

Thesis Bi-objective mathematical model for optimal sequencing of two-level factorial designs

Pureza, V. M.M.; Oprime, P. C.; Costa, A. F.B. [UNESP] et al. · 2021 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Bi-objective mathematical model for optimal sequencing of two-level factorial designs

Authors: Pureza, V. M.M.; Oprime, P. C.; Costa, A. F.B. [UNESP]; Morales, D.

Year: 2021

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1214/19-BJPS453

Thesis Optimisation of a continuous flash fermentation for butanol production using the response surface methodology

Mariano, Adriano Pinto; Borba Costa, Caliane Bastos; de Angelis, Dejanira de Franceschi [UNESP] et al. · 2013 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Optimisation of a continuous flash fermentation for butanol production using the response surface methodology

Authors: Mariano, Adriano Pinto; Borba Costa, Caliane Bastos; de Angelis, Dejanira de Franceschi [UNESP]; Maugeri Filho, Francisco; Pires Atala, Daniel Ibraim; Wolf Maciel, Maria Regina; Maciel Filho, Rubens

Year: 2013

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1016/j.cherd.2009.11.002

Thesis iCFD: Interpreted Computational Fluid Dynamics – Degeneration of CFD to one-dimensional advection-dispersion models using statistical experimental design – The secondary clarifier

Guyonvarch, Estelle; Ramin, Elham; id_orcid 0000-0002-2301-7492 et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: iCFD: Interpreted Computational Fluid Dynamics – Degeneration of CFD to one-dimensional advection-dispersion models using statistical experimental design – The secondary clarifier

Authors: Guyonvarch, Estelle; Ramin, Elham; id_orcid 0000-0002-2301-7492; Kulahci, Murat; id_orcid 0000-0003-4222-9631; Plósz, Benedek G.

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/fba1b036-0b6f-4c59-942c-0573887cc9e0

Thesis Optimization Strategies Based on Sequential Quadratic Programming Applied for a Fermentation Process for Butanol Production

Mariano, Adriano Pinto; Borba Costa, Caliane Bastos; de Angelis, Dejanira de Franceschi [UNESP] et al. · 2013 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Optimization Strategies Based on Sequential Quadratic Programming Applied for a Fermentation Process for Butanol Production

Year: 2013

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1007/s12010-008-8450-6

Thesis Assessment of artificial neural networks to predict red colorant production by Talaromyces amestolkiae

dos Reis, Bianca Dalbem [UNESP]; de Oliveira, Fernanda [UNESP]; Santos-Ebinuma, Valéria C. [UNESP] et al. · 2023 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Assessment of artificial neural networks to predict red colorant production by Talaromyces amestolkiae

Authors: dos Reis, Bianca Dalbem [UNESP]; de Oliveira, Fernanda [UNESP]; Santos-Ebinuma, Valéria C. [UNESP]; Filletti, Érica Regina [UNESP]; de Baptista Neto, Álvaro [UNESP]

Year: 2023

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1007/s00449-022-02819-4

Thesis Response surface experiments on processes with high variation

Gilmour, Steven G.; Trinca, Luzia A. [UNESP] · 2022 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Response surface experiments on processes with high variation

Authors: Gilmour, Steven G.; Trinca, Luzia A. [UNESP]

Year: 2022

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1142/9789812774736_0002

Thesis Optimization of temperature, sugar concentration, and inoculum size to maximize ethanol production without significant decrease in yeast cell viability

Laluce, Cecília [UNESP]; Tognolli, Joao Olimpio [UNESP]; de Oliveira, Karen Fernanda et al. · 2014 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Optimization of temperature, sugar concentration, and inoculum size to maximize ethanol production without significant decrease in yeast cell viability

Authors: Laluce, Cecília [UNESP]; Tognolli, Joao Olimpio [UNESP]; de Oliveira, Karen Fernanda; Souza, Crisla Serra; Morais, Meline Rezende [UNESP]

Year: 2014

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1007/s00253-009-1885-z

Thesis Some Contributions to Design Theory and Applications

Mandal, Abhyuday · 2005 · Georgia Institute of Technology · DOI

Full title: Some Contributions to Design Theory and Applications

Authors: Mandal, Abhyuday

Year: 2005

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/7142

Thesis Comparing a polynomial DOE model and an ANN model for enhanced geranyl cinnamate biosynthesis with Novozym® 435 lipase

do Nascimento, João Francisco Cabral [UNESP]; dos Reis, Bianca Dalbem [UNESP]; de Baptista Neto, Álvaro [UNESP] et al. · 2025 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Comparing a polynomial DOE model and an ANN model for enhanced geranyl cinnamate biosynthesis with Novozym® 435 lipase

Authors: do Nascimento, João Francisco Cabral [UNESP]; dos Reis, Bianca Dalbem [UNESP]; de Baptista Neto, Álvaro [UNESP]; Lerin, Lindomar Alberto; Oliveira, José Vladimir de; de Paula, Ariela Veloso [UNESP]; Remonatto, Daniela [UNESP]

Year: 2025

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1016/j.bcab.2024.103240

Thesis Optimization of Factor Combinations for Stem Cell Differentiations on a Design-of-Experiment Microfluidic Chip

Li, Lijun CHEM; Tan, Deng; Liu, Shuqin et al. · 2020 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Optimization of Factor Combinations for Stem Cell Differentiations on a Design-of-Experiment Microfluidic Chip

Authors: Li, Lijun CHEM; Tan, Deng; Liu, Shuqin; Jiao, Ruifeng; Yang, Xiaofei; Li, Furong; Wu, Hongkai; Huang, Wei

Year: 2020

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-107340

Thesis Inner-phase and inter-phase analysis based operating performance assessment and nonoptimal cause identification for multiphase batch processes

Liu, Yan CBE; Ma, R.; Wang, F. et al. · 2018 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Inner-phase and inter-phase analysis based operating performance assessment and nonoptimal cause identification for multiphase batch processes

Authors: Liu, Yan CBE; Ma, R.; Wang, F.; Chang, Y.; Gao, Furong

Year: 2018

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-91038

Thesis Improved Nonlinear Quality Estimation for Multiphase Batch Processes Based on Relevance Vector Machine with Neighborhood Component Variable Selection

Zhu, Jinlin CBME; Gao, Furong · 2018 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Improved Nonlinear Quality Estimation for Multiphase Batch Processes Based on Relevance Vector Machine with Neighborhood Component Variable Selection

Authors: Zhu, Jinlin CBME; Gao, Furong

Year: 2018

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-89216

Thesis Improved calibration investigation using phase-wise local and cumulative quality interpretation and prediction

Zhao, Chunhui; Wang, Fuh; Gao, Furong · 2009 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Improved calibration investigation using phase-wise local and cumulative quality interpretation and prediction

Authors: Zhao, Chunhui; Wang, Fuh; Gao, Furong

Year: 2009

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-18128

Thesis Gaussian Process Regression and Bayesian Inference Based Operating Performance Assessment for Multiphase Batch Processes

Liu, Yan CBE; Wang, Xiaojun; Wang, Fuli et al. · 2018 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Gaussian Process Regression and Bayesian Inference Based Operating Performance Assessment for Multiphase Batch Processes

Authors: Liu, Yan CBE; Wang, Xiaojun; Wang, Fuli; Gao, Furong

Year: 2018

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-90877

Thesis Comparative assessment of simulation-based and surrogate-based approaches to flowsheet optimization using dimensionality reduction

Triantafyllou, Niki; Lyons, Ben; Bernardi, Andrea et al. · 2024 · Imperial College London · DOI

Full title: Comparative assessment of simulation-based and surrogate-based approaches to flowsheet optimization using dimensionality reduction

Authors: Triantafyllou, Niki; Lyons, Ben; Bernardi, Andrea; Chachuat, Benoit; Kontoravdi, Cleo; Papathanasiou, Maria M

Year: 2024

Venue: Imperial College London

DOI: http://dx.doi.org/10.1016/j.compchemeng.2024.108807

Thesis Systematic development of predictive mathematical models for animal cell cultures

Kontoravdi, Cleo; Pistikopoulos, Efstratios N; Mantalaris, Athanasios · 2014 · Imperial College London · DOI

Full title: Systematic development of predictive mathematical models for animal cell cultures

Authors: Kontoravdi, Cleo; Pistikopoulos, Efstratios N; Mantalaris, Athanasios

Year: 2014

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000279658700003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis A model-based approach towards accelerated process development: a case study on chromatography

Sachio, Steven; Kontoravdi, Cleo; Papathanasiou, Maria M · 2024 · Imperial College London · DOI

Full title: A model-based approach towards accelerated process development: a case study on chromatography

Authors: Sachio, Steven; Kontoravdi, Cleo; Papathanasiou, Maria M

Year: 2024

Venue: Imperial College London

DOI: https://www.sciencedirect.com/science/article/pii/S0263876223005166

Thesis Computer-aided design space identification for screening of protein A affinity chromatography resins

Sachio, Steven; Likozar, Blaz; Kontoravdi, Cleo et al. · 2024 · Imperial College London · DOI

Full title: Computer-aided design space identification for screening of protein A affinity chromatography resins

Authors: Sachio, Steven; Likozar, Blaz; Kontoravdi, Cleo; Papathanasiou, Maria M

Year: 2024

Venue: Imperial College London

DOI: https://www.sciencedirect.com/science/article/pii/S0021967324002644

Thesis Data-driven optimization for process systems engineering applications

van de Berg, Damien; Savage, Thomas; Petsagkourakis, Panagiotis et al. · 2023 · Imperial College London · DOI

Full title: Data-driven optimization for process systems engineering applications

Authors: van de Berg, Damien; Savage, Thomas; Petsagkourakis, Panagiotis; Zhang, Dongda; Shah, Nilay; del Rio-Chanona, Ehecatl Antonio

Year: 2023

Venue: Imperial College London

DOI: http://dx.doi.org/10.1016/j.ces.2021.117135

Thesis In silico dynamic optimisation studies for batch/fed-batch mammalian cell suspension cultures producing biopharmaceuticals

Lam, Ming-Chi · 2017 · Imperial College London · DOI

Full title: In silico dynamic optimisation studies for batch/fed-batch mammalian cell suspension cultures producing biopharmaceuticals

Authors: Lam, Ming-Chi

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/45465

Thesis A platform for the optimisation of metabolic pathways for glycosylation to achieve a narrow and targeted glycoform distribution

Jedrzejewski, Philip · 2017 · Imperial College London · DOI

Full title: A platform for the optimisation of metabolic pathways for glycosylation to achieve a narrow and targeted glycoform distribution

Authors: Jedrzejewski, Philip

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/53386

Thesis Real-time online in situ monitoring and statistical design strategies for haematopoietic stem cell bioprocessing

Lim, Mayasari; Lim, Mayasari · 2010 · Imperial College London · DOI

Full title: Real-time online in situ monitoring and statistical design strategies for haematopoietic stem cell bioprocessing

Authors: Lim, Mayasari; Lim, Mayasari

Year: 2010

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/4408

Thesis The influence of design parameters on the separation of biomass in mini-hydrocyclones

Brito Parada, P; Dewes, Ruben; Vega Garcia, Dennis et al. · 2018 · Imperial College London · DOI

Full title: The influence of design parameters on the separation of biomass in mini-hydrocyclones

Authors: Brito Parada, P; Dewes, Ruben; Vega Garcia, Dennis; Cilliers, Jan

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/63975

Thesis An optimization framework to combine operable space maximization with design of experiments

Chen, Qi; Paulavicius, R; Adjiman, CSJ et al. · 2018 · Imperial College London · DOI

Full title: An optimization framework to combine operable space maximization with design of experiments

Authors: Chen, Qi; Paulavicius, R; Adjiman, CSJ; Garcia-Munoz, Salvador

Year: 2018

Venue: Imperial College London

DOI: https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/aic.16214

Thesis Computationally efficient identification of probabilistic design spaces through application of metamodeling and adaptive sampling

Kucherenko, Sergei; Giamalakis, Dimitrios; Shah, Nilay et al. · 2019 · Imperial College London · DOI

Full title: Computationally efficient identification of probabilistic design spaces through application of metamodeling and adaptive sampling

Authors: Kucherenko, Sergei; Giamalakis, Dimitrios; Shah, Nilay; García-Muñoz, Salvador

Year: 2019

Venue: Imperial College London

DOI: https://www.sciencedirect.com/science/article/pii/S0098135419308877?via%3Dihub

Thesis Recombinant β-carotene production by yarrowia lipolytica - assessing the potential of micro-scale fermentation analysis in cell factory design and bioreaction optimization

Jacobsen, Irene Hjorth; Ledesma-Amaro, Rodrigo; Martinez, José Luis · 2020 · Imperial College London · DOI

Full title: Recombinant β-carotene production by yarrowia lipolytica - assessing the potential of micro-scale fermentation analysis in cell factory design and bioreaction optimization

Authors: Jacobsen, Irene Hjorth; Ledesma-Amaro, Rodrigo; Martinez, José Luis

Year: 2020

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/32117917

Thesis Bayesian approach to probabilistic design space characterization: a nested sampling strategy

Kusumo, Kennedy P; Gomoescu, Lucian; Paulen, Radoslav et al. · 2020 · Imperial College London · DOI

Full title: Bayesian approach to probabilistic design space characterization: a nested sampling strategy

Authors: Kusumo, Kennedy P; Gomoescu, Lucian; Paulen, Radoslav; García Muñoz, Salvador; Pantelides, Constantinos C; Shah, Nilay; Chachuat, Benoît

Year: 2020

Venue: Imperial College London

DOI: https://pubs.acs.org/doi/abs/10.1021/acs.iecr.9b05006

Thesis Strategic framework for parameterization of cell culture models

Kotidis, Pavlos; Kontoravdi, Cleo · 2019 · Imperial College London · DOI

Full title: Strategic framework for parameterization of cell culture models

Authors: Kotidis, Pavlos; Kontoravdi, Cleo

Year: 2019

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000464443100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Mathematical modelling for bioprocess understanding and optimisation

Alhuthali, Sakhr · 2020 · Imperial College London · DOI

Full title: Mathematical modelling for bioprocess understanding and optimisation

Authors: Alhuthali, Sakhr

Year: 2020

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/84849

Thesis Design of dynamic experiments for black-box model discrimination

Olofsson, Simon; Schultz, Eduardo S; Mhamdi, Adel et al. · 2021 · Imperial College London · DOI

Full title: Design of dynamic experiments for black-box model discrimination

Authors: Olofsson, Simon; Schultz, Eduardo S; Mhamdi, Adel; Mitsos, Alexander; Deisenroth, Marc Peter; Misener, Ruth

Year: 2021

Venue: Imperial College London

DOI: http://arxiv.org/abs/2102.03782v1

Thesis Risk mitigation in model-based experiment design: a continuous-effort approach to optimal campaigns

Kusumo, kennedy; Kuriyan, kamal; Vaidyaraman, Shankarraman et al. · 2022 · Imperial College London · DOI

Full title: Risk mitigation in model-based experiment design: a continuous-effort approach to optimal campaigns

Authors: Kusumo, kennedy; Kuriyan, kamal; Vaidyaraman, Shankarraman; Garcia Munoz, Salvador; Shah, nilay; Chachuat, Benoit

Year: 2022

Venue: Imperial College London

DOI: https://www.sciencedirect.com/science/article/pii/S0098135422000242?via%3Dihub

Thesis Development of a combined mathematical and experimental framework for the control and optimisation of mammalian cell culture systems

Kyparissidis, Alexandros-Dimitrios · 2012 · Imperial College London · DOI

Full title: Development of a combined mathematical and experimental framework for the control and optimisation of mammalian cell culture systems

Authors: Kyparissidis, Alexandros-Dimitrios

Year: 2012

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/9657

Thesis Maximizing neotissue growth kinetics in a perfusion bioreactor: An in silico strategy using model reduction and Bayesian optimization

Mehrian, Mohammad; Guyot, Yann; Papantoniou, Ioannis et al. · 2021 · Imperial College London · DOI

Full title: Maximizing neotissue growth kinetics in a perfusion bioreactor: An in silico strategy using model reduction and Bayesian optimization

Authors: Mehrian, Mohammad; Guyot, Yann; Papantoniou, Ioannis; Olofsson, Simon; Sonnaert, Maarten; Misener, Ruth; Geris, Liesbet

Year: 2021

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000423672800010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis A design centering methodology for probabilistic design space

Kusumo, Kennedy P; Morrissey, James; Mitchell, Hamish et al. · 2022 · Imperial College London · DOI

Full title: A design centering methodology for probabilistic design space

Authors: Kusumo, Kennedy P; Morrissey, James; Mitchell, Hamish; Shah, Nilay; Chachuat, Benoit

Year: 2022

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000694048400015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Algorithms and Tools for Feasibility Analysis and Optimal Experiment Design in Pharmaceutical Manufacturing

Kusumo, Kennedy · 2022 · Imperial College London · DOI

Full title: Algorithms and Tools for Feasibility Analysis and Optimal Experiment Design in Pharmaceutical Manufacturing

Authors: Kusumo, Kennedy

Year: 2022

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/96978

Thesis Population balance modelling captures host cell protein dynamics in CHO cell cultures

Alhuthali, Sakhr; Kontoravdi, Cleo · 2022 · Imperial College London · DOI

Full title: Population balance modelling captures host cell protein dynamics in CHO cell cultures

Authors: Alhuthali, Sakhr; Kontoravdi, Cleo

Year: 2022

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/96277

Thesis Multi-Objective Optimization of Experiments Using Curvature and Fisher Information Matrix

Manesso, Erica; Sridharan, Srinath; Gunawan, Rudiyanto · 2017 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Multi-Objective Optimization of Experiments Using Curvature and Fisher Information Matrix

Authors: Manesso, Erica; Sridharan, Srinath; Gunawan, Rudiyanto

Year: 2017

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/235038

Thesis Bioprocess in-line monitoring using Raman spectroscopy and Indirect Hard Modeling (IHM): A simple calibration yields a robust model

Müller, David Heinrich; Flake, Carsten; Brands, Thorsten et al. · 2023 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Bioprocess in-line monitoring using Raman spectroscopy and Indirect Hard Modeling (IHM): A simple calibration yields a robust model

Authors: Müller, David Heinrich; Flake, Carsten; Brands, Thorsten; Koß, Hans-Jürgen

Year: 2023

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/614575

Thesis Automated Conditional Screening of Multiple Escherichia coli Strains in Parallel Adaptive Fed-Batch Cultivations

Hans, Sebastian; Haby, Benjamin; Krausch, Niels et al. · 2020 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Automated Conditional Screening of Multiple Escherichia coli Strains in Parallel Adaptive Fed-Batch Cultivations

Authors: Hans, Sebastian; Haby, Benjamin; Krausch, Niels; id_orcid0000-0003-2325-6001; Barz, Tilman; Neubauer, Peter; Cruz Bournazou, Mariano Nicolas; id_orcid0000-0003-2325-6001

Year: 2020

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/452303

Thesis Improving extracellular vesicles production through a Bayesian optimization-based experimental design

Bader, Johannes; Narayanan, Harini; Arosio, Paolo et al. · 2023 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Improving extracellular vesicles production through a Bayesian optimization-based experimental design

Authors: Bader, Johannes; Narayanan, Harini; Arosio, Paolo; Leroux, Jean-Christophe; id_orcid0000-0001-5601-1292

Year: 2023

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/589502

Thesis Accelerated Bioprocess Development of Endopolygalacturonase-Production with Saccharomyces cerevisiae Using Multivariate Prediction in a 48 Mini-Bioreactor Automated Platform

Sawatzki, Annina; Hans, Sebastian; Narayanan, Harini et al. · 2018 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Accelerated Bioprocess Development of Endopolygalacturonase-Production with Saccharomyces cerevisiae Using Multivariate Prediction in a 48 Mini-Bioreactor Automated Platform

Authors: Sawatzki, Annina; Hans, Sebastian; Narayanan, Harini; Haby, Benjamin; Krausch, Niels; Sokolov, Michael; Glauche, Florian; Riedel, Sebastian L.; Neubauer, Peter; Cruz Bournazou, Mariano Nicolas; id_orcid0000-0001-9461-4414

Year: 2018

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/364323

Thesis Optimal experimental design of physical property measurements for optimal chemical process simulations

Fleitmann, Lorenz; Pyschik, Jan; Wolff, Ludger et al. · 2022 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Optimal experimental design of physical property measurements for optimal chemical process simulations

Authors: Fleitmann, Lorenz; Pyschik, Jan; Wolff, Ludger; Schilling, Johannes; id_orcid0000-0001-8013-5439; Bardow, André; id_orcid0000-0001-8013-5439

Year: 2022

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/532737

Thesis A Customized Bayesian Algorithm to Optimize Enzyme-Catalyzed Reactions

Tachibana, Ryo; Zhang, Kailin; Zou, Zhi et al. · 2023 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: A Customized Bayesian Algorithm to Optimize Enzyme-Catalyzed Reactions

Authors: Tachibana, Ryo; Zhang, Kailin; Zou, Zhi; Burgener, Simon; Ward, Thomas R.

Year: 2023

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/627410

Thesis Design of Biopharmaceutical Formulations Accelerated by Machine Learning

Narayanan, Harini; Dingfelder, Fabian; Morales, Itzel Condado et al. · 2021 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Design of Biopharmaceutical Formulations Accelerated by Machine Learning

Authors: Narayanan, Harini; Dingfelder, Fabian; Morales, Itzel Condado; Patel, Bhargav; Heding, Kristine Enemærke; Bjelke, Jais Rose; Egebjerg, Thomas; Butté, Alessandro; Sokolov, Michael; Lorenzen, Nikolai; Arosio, Paolo

Year: 2021

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/511943

Thesis Algebraic surrogate-based flexibility analysis of process units with complicating process constraints

Forster, Tim; id_orcid0000-0001-8939-9588; Vázquez, Daniel et al. · 2024 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Algebraic surrogate-based flexibility analysis of process units with complicating process constraints

Authors: Forster, Tim; id_orcid0000-0001-8939-9588; Vázquez, Daniel; Moreno-Palancas, Isabela Fons; Guillén Gosálbez, Gonzalo; id_orcid0000-0001-8939-9588

Year: 2024

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/666223

Thesis Model-based design of experiments for adsorption isotherms

Henninger, Matthias; Postweiler, Patrik; Engelpracht, Mirko et al. · 2025 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Model-based design of experiments for adsorption isotherms

Authors: Henninger, Matthias; Postweiler, Patrik; Engelpracht, Mirko; Galvanin, Federico; Bardow, André; id_orcid0000-0002-3831-0691

Year: 2025

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/785289

Thesis Bayesian Optimization for Efficient Multiobjective Formulation Development of Biologics

Waibel , Isabel; Schneider, Timo; id_orcid0000-0002-8989-1406 et al. · 2025 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Bayesian Optimization for Efficient Multiobjective Formulation Development of Biologics

Authors: Waibel , Isabel; Schneider, Timo; id_orcid0000-0002-8989-1406; Fischer , Fiona J.; Dumnoenchanvanit , Poonpat; Kulakova , Alina; Nguyen , Tin Duy; Egebjerg , Thomas; Bertelsen , Søren; Lorenzen , Nikolai; Arosio , Paolo

Year: 2025

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/786953

Thesis Hybrid analytical surrogate-based process optimization via Bayesian symbolic regression

Jog, Sachin; Vázquez, Daniel; Santos, Lucas F. et al. · 2024 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Hybrid analytical surrogate-based process optimization via Bayesian symbolic regression

Authors: Jog, Sachin; Vázquez, Daniel; Santos, Lucas F.; Santos, José A.; Guillén Gosálbez, Gonzalo; id_orcid0000-0001-6074-8473

Year: 2024

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/653652

Patent us-2013288288-a1

· 2013

Full title: us-2013288288-a1

Year: 2013

Patent us-2016224721-a1

· 2016

Full title: us-2016224721-a1

Year: 2016

Patent us-2017016864-a1

· 2017

Full title: us-2017016864-a1

Year: 2017

Patent us-2016378909-a1

· 2016

Full title: us-2016378909-a1

Year: 2016

Patent us-2024085388-a1

· 2024

Full title: us-2024085388-a1

Year: 2024

Patent us-8889372-b2

· 2014

Full title: us-8889372-b2

Year: 2014

2. Data Extraction

0/534 extracted

Paper

Design and optimization of an IgG human ELISA assay reactive to recombinant RBD SARS-CoV-2 protein.

Rodríguez, María Celeste; Ceaglio, Natalia; Gugliotta, Agustina et al. · 2022

Full title: Design and optimization of an IgG human ELISA assay reactive to recombinant RBD SARS-CoV-2 protein.

DOI: https://doi.org/10.1007/s00253-022-12254-w

Paper

Optimized biosynthesis of bioactive silver nanoparticle-kombucha cellulose nanocomposites for enhanced antimicrobial applications.

Aboul-Nasr, M Bassam; Yasien, Alaa A; Mohamed, Sabah S et al. · 2025

Full title: Optimized biosynthesis of bioactive silver nanoparticle-kombucha cellulose nanocomposites for enhanced antimicrobial applications.

Authors: Aboul-Nasr, M Bassam; Yasien, Alaa A; Mohamed, Sabah S; Obiedallah, Marwa

DOI: https://doi.org/10.1007/s00253-025-13585-0

Paper

Endophytic Aspergillus fumigatiaffinis: Novel paclitaxel production and optimization insights.

Obiedallah, Marwa; Yasien, Alaa A; Mohamed, Sabah S et al. · 2024

Full title: Endophytic Aspergillus fumigatiaffinis: Novel paclitaxel production and optimization insights.

Authors: Obiedallah, Marwa; Yasien, Alaa A; Mohamed, Sabah S; Aboul-Nasr, M Bassam

DOI: https://doi.org/10.1007/s00253-024-13230-2

Paper

Recombinant T7 RNA polymerase production using ClearColi BL21(DE3) and animal-free media for in vitro transcription.

Liang, Qianying; Tu, Bowen; Cui, Lun · 2024

Full title: Recombinant T7 RNA polymerase production using ClearColi BL21(DE3) and animal-free media for in vitro transcription.

Authors: Liang, Qianying; Tu, Bowen; Cui, Lun

DOI: https://doi.org/10.1007/s00253-023-12939-w

Paper

Optimisation of the fermentation media to enhance the production of the bioactive isomer of vitamin menaquinone-7.

Lal, Neha; Seifan, Mostafa; Berenjian, Aydin · 2022

Full title: Optimisation of the fermentation media to enhance the production of the bioactive isomer of vitamin menaquinone-7.

Authors: Lal, Neha; Seifan, Mostafa; Berenjian, Aydin

DOI: https://doi.org/10.1007/s00449-022-02752-6

Paper

Design modification and optimisation of the perfusion system of a tri-axial bioreactor for tissue engineering.

Hussein, Husnah; Williams, David J; Liu, Yang · 2015

Full title: Design modification and optimisation of the perfusion system of a tri-axial bioreactor for tissue engineering.

Authors: Hussein, Husnah; Williams, David J; Liu, Yang

DOI: https://doi.org/10.1007/s00449-015-1371-1

Paper

Model-assisted DoE software: optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses.

Moser, André; Kuchemüller, Kim B; Deppe, Sahar et al. · 2021

Full title: Model-assisted DoE software: optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses.

Authors: Moser, André; Kuchemüller, Kim B; Deppe, Sahar; Hernández Rodríguez, Tanja; Frahm, Björn; Pörtner, Ralf; Hass, Volker C; Möller, Johannes

DOI: https://doi.org/10.1007/s00449-020-02478-3

Paper

Design of experiments and machine learning with application to industrial experiments

Fontana, Roberto; Molena, Alberto; Pegoraro, Luca et al. · 2023

Full title: Design of experiments and machine learning with application to industrial experiments

Authors: Fontana, Roberto; Molena, Alberto; Pegoraro, Luca; Salmaso, Luigi

DOI: https://doi.org/10.1007/s00362-023-01437-w

Paper

Tuning Dunaliella tertiolecta for Enhanced Antioxidant Production by Modification of Culture Conditions.

Roy, Uttam K; Nielsen, Birthe V; Milledge, John J · 2021

Full title: Tuning Dunaliella tertiolecta for Enhanced Antioxidant Production by Modification of Culture Conditions.

Authors: Roy, Uttam K; Nielsen, Birthe V; Milledge, John J

DOI: https://doi.org/10.1007/s10126-021-10041-8

Paper

Efficient design of experiments for sensitivity analysis based on polynomial chaos expansions

Evgeny Burnaev; I. Panin; B. Sudret · 2017

Full title: Efficient design of experiments for sensitivity analysis based on polynomial chaos expansions

Authors: Evgeny Burnaev; I. Panin; B. Sudret

DOI: https://doi.org/10.1007/s10472-017-9542-1

Paper

Design of experiment (DOE) applied to artificial neural network architecture enables rapid bioprocess improvement.

Rodriguez-Granrose, Daniel; Jones, Amanda; Loftus, Hannah et al. · 2021

Full title: Design of experiment (DOE) applied to artificial neural network architecture enables rapid bioprocess improvement.

Authors: Rodriguez-Granrose, Daniel; Jones, Amanda; Loftus, Hannah; Tandeski, Terry; Heaton, Will; Foley, Kevin T; Silverman, Lara

DOI: https://doi.org/10.1007/s00449-021-02529-3

Paper

Research on the ability of propionic acid and vitamin B12 biosynthesis by Propionibacterium freudenreichii strain T82.

Piwowarek, Kamil; Lipińska, Edyta; Hać-Szymańczuk, Elżbieta et al. · 2018

Full title: Research on the ability of propionic acid and vitamin B12 biosynthesis by Propionibacterium freudenreichii strain T82.

Authors: Piwowarek, Kamil; Lipińska, Edyta; Hać-Szymańczuk, Elżbieta; Bzducha-Wróbel, Anna; Synowiec, Alicja

DOI: https://doi.org/10.1007/s10482-017-0991-7

Paper

Design of experiments approach to engineer cell-secreted matrices for directing osteogenic differentiation.

Decaris, Martin L; Leach, J Kent · 2011

Full title: Design of experiments approach to engineer cell-secreted matrices for directing osteogenic differentiation.

Authors: Decaris, Martin L; Leach, J Kent

DOI: https://doi.org/10.1007/s10439-010-0217-x

Paper

Tuning the Microenvironment to Create Functionally Distinct Mesenchymal Stromal Cell Spheroids.

Thai, Victoria L; Candelas, Diego O; Leach, J Kent · 2023

Full title: Tuning the Microenvironment to Create Functionally Distinct Mesenchymal Stromal Cell Spheroids.

Authors: Thai, Victoria L; Candelas, Diego O; Leach, J Kent

DOI: https://doi.org/10.1007/s10439-023-03162-9

Paper

Influences of operational parameters on phosphorus removal in batch and continuous electrocoagulation process performance

D. Nguyen; Y. Yoon; X. Bui et al. · 2017

Full title: Influences of operational parameters on phosphorus removal in batch and continuous electrocoagulation process performance

Authors: D. Nguyen; Y. Yoon; X. Bui; Sung Su Kim; S. Chang; Wenshan Guo; H. Ngo

DOI: https://doi.org/10.1007/s11356-017-0180-2

Paper

Statistical investigation of extraction parameters of keratin from chicken feather using Design-Expert.

Kamarudin, Nuruldiyanah Binti; Sharma, Swati; Gupta, Arun et al. · 2017

Full title: Statistical investigation of extraction parameters of keratin from chicken feather using Design-Expert.

Authors: Kamarudin, Nuruldiyanah Binti; Sharma, Swati; Gupta, Arun; Kee, Chua Gek; Chik, Syed Mohd Saufi Bin Tuan; Gupta, Ritu

DOI: https://doi.org/10.1007/s13205-017-0767-9

Paper

Enhanced production of thermostable amidase from Geobacillus subterraneus RL-2a MTCC 11502 via optimization of physicochemical parameters using Taguchi DOE methodology.

Mehta, Praveen Kumar; Bhatia, Shashi Kant; Bhatia, Ravi Kant et al. · 2016

Full title: Enhanced production of thermostable amidase from Geobacillus subterraneus RL-2a MTCC 11502 via optimization of physicochemical parameters using Taguchi DOE methodology.

Authors: Mehta, Praveen Kumar; Bhatia, Shashi Kant; Bhatia, Ravi Kant; Bhalla, Tek Chand

DOI: https://doi.org/10.1007/s13205-016-0390-1

Paper

Oxidative Depolymerization of Lignosulfonates for Muconic Acid Production Using Recombinant Pseudomonas putida CJ475

Selda Bekirovska; F. Lund; L. I. Ajakaiye Jensen et al. · 2025

Full title: Oxidative Depolymerization of Lignosulfonates for Muconic Acid Production Using Recombinant Pseudomonas putida CJ475

Authors: Selda Bekirovska; F. Lund; L. I. Ajakaiye Jensen; Christian P. Hulteberg; M. Gorwa-Grauslund; Omar Y. Abdelaziz

DOI: https://doi.org/10.1007/s12649-025-02890-4

Paper

Development of semi-defined rice straw-based medium for butanol production and its kinetic study.

Ranjan, Amrita; Mayank, Rahul; Moholkar, Vijayanand S · 2013

Full title: Development of semi-defined rice straw-based medium for butanol production and its kinetic study.

Authors: Ranjan, Amrita; Mayank, Rahul; Moholkar, Vijayanand S

DOI: https://doi.org/10.1007/s13205-013-0120-x

Paper

Statistical optimization of chitosan-based synthesis strategies to generate albumin nanoparticles.

Martín-Escaño, Aitana; Barbuzano, Claudia; Rodríguez-Díaz, Juan Manuel et al. · 2026

Full title: Statistical optimization of chitosan-based synthesis strategies to generate albumin nanoparticles.

Authors: Martín-Escaño, Aitana; Barbuzano, Claudia; Rodríguez-Díaz, Juan Manuel; Pérez-Herrero, Edgar

DOI: https://doi.org/10.1007/s13346-026-02046-4

Paper

Optimization of gelatinolytic enzyme production by B. amyloliquefaciens sp. H11 through Plackett–Burman design and response surface methodology

S. Sai-ut; S. Benjakul; P. Sumpavapol et al. · 2014

Full title: Optimization of gelatinolytic enzyme production by B. amyloliquefaciens sp. H11 through Plackett–Burman design and response surface methodology

Authors: S. Sai-ut; S. Benjakul; P. Sumpavapol; H. Kishimura

DOI: https://doi.org/10.1007/s40071-014-0059-5

Paper

Application of Sono–photo-Fenton process for degradation of phenol derivatives in petrochemical wastewater using full factorial design of experiment

Shokri, Aref · 2018

Full title: Application of Sono–photo-Fenton process for degradation of phenol derivatives in petrochemical wastewater using full factorial design of experiment

Authors: Shokri, Aref

DOI: https://doi.org/10.1007/s40090-018-0159-y

Paper

3D printed ceramics as solid supports for enzyme immobilization: an automated DoE approach for applications in continuous flow.

Valotta, Alessia; Maier, Manuel C; Soritz, Sebastian et al. · 2021

Full title: 3D printed ceramics as solid supports for enzyme immobilization: an automated DoE approach for applications in continuous flow.

Authors: Valotta, Alessia; Maier, Manuel C; Soritz, Sebastian; Pauritsch, Magdalena; Koenig, Michael; Brouczek, Dominik; Schwentenwein, Martin; Gruber-Woelfler, Heidrun

DOI: https://doi.org/10.1007/s41981-021-00163-4

Paper

HPLC-PDA analysis of ACE-inhibitors, hydrochlorothiazide and indapamide utilizing design of experiments

Dawud, Eyad Rashed; Shakya, Ashok K. · 2014

Full title: HPLC-PDA analysis of ACE-inhibitors, hydrochlorothiazide and indapamide utilizing design of experiments

Authors: Dawud, Eyad Rashed; Shakya, Ashok K.

DOI: https://doi.org/10.1016/j.arabjc.2014.10.052

Paper

Development and validation of simple RP-HPLC-PDA analytical protocol for zileuton assisted with Design of Experiments for robustness determination

Ganorkar, Saurabh B.; Dhumal, Dinesh; Shirkhedkar, Atul A. · 2014

Full title: Development and validation of simple RP-HPLC-PDA analytical protocol for zileuton assisted with Design of Experiments for robustness determination

Authors: Ganorkar, Saurabh B.; Dhumal, Dinesh; Shirkhedkar, Atul A.

DOI: https://doi.org/10.1016/j.arabjc.2014.03.009

Paper

Blocking response surface designs

Peter Goos; A. Donev · 2006

Full title: Blocking response surface designs

Authors: Peter Goos; A. Donev

DOI: https://doi.org/10.1016/j.csda.2005.11.003

Paper

Modeling and optimization of factors influencing adsorptive performance of agrowaste-derived nanocellulose/iron oxide nanobiocomposites during remediation of arsenic contaminated groundwater.

Julie Baruah; C. Chaliha; E. Kalita et al. · 2020

Authors: Julie Baruah; C. Chaliha; E. Kalita; B. Nath; R. A. Field; Pritam Deb

DOI: https://doi.org/10.1016/j.ijbiomac.2020.07.113

Paper

Co-treatment of landfill leachate and municipal wastewater using the ZELIAC/zeolite constructed wetland system.

A. Mojiri; Ziyang Lou; R. Tajuddin et al. · 2016

Full title: Co-treatment of landfill leachate and municipal wastewater using the ZELIAC/zeolite constructed wetland system.

Authors: A. Mojiri; Ziyang Lou; R. Tajuddin; Hossein Farraji; N. Alifar

DOI: https://doi.org/10.1016/j.jenvman.2015.10.020

Paper

Mixture design as a tool for improving full-to-empty particle ratios across various GOIs in rAAV production.

Tzimou, Konstantina; Hulsbus-Andreu, Pol; Yildirim, Ece Bahar et al. · 2026

Full title: Mixture design as a tool for improving full-to-empty particle ratios across various GOIs in rAAV production.

Authors: Tzimou, Konstantina; Hulsbus-Andreu, Pol; Yildirim, Ece Bahar; Nielsen, Lars K; Lavado-García, Jesús

DOI: https://doi.org/10.1038/s41434-025-00546-5

Paper

Optimization of Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Mass Spectrometry Detection of Glutamine-FMOC Ad-Hoc Derivative by Central Composite Design.

Bheemanapally, Khaggeswar; Ibrahim, Mostafa M H; Briski, Karen P · 2020

Full title: Optimization of Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Mass Spectrometry Detection of Glutamine-FMOC Ad-Hoc Derivative by Central Composite Design.

Authors: Bheemanapally, Khaggeswar; Ibrahim, Mostafa M H; Briski, Karen P

DOI: https://doi.org/10.1038/s41598-020-64099-w

Paper

Preclinical optimization of an enterotoxigenic Escherichia coli adjuvanted subunit vaccine using response surface design of experiments.

Poncet, David; Hessler, Catherine; Liang, Hong et al. · 2020

Full title: Preclinical optimization of an enterotoxigenic Escherichia coli adjuvanted subunit vaccine using response surface design of experiments.

DOI: https://doi.org/10.1038/s41541-020-00228-w

Paper

Parameters influencing the size of chitosan-TPP nano- and microparticles.

Sreekumar, Sruthi; Goycoolea, Francisco M; Moerschbacher, Bruno M et al. · 2018

Full title: Parameters influencing the size of chitosan-TPP nano- and microparticles.

Authors: Sreekumar, Sruthi; Goycoolea, Francisco M; Moerschbacher, Bruno M; Rivera-Rodriguez, Gustavo R

DOI: https://doi.org/10.1038/s41598-018-23064-4

Paper

Utilisation of Design of Experiments Approach to Optimise Supercritical Fluid Extraction of Medicinal Cannabis

Rochfort, Simone; Isbel, Ashley; Ezernieks, Vilnis et al. · 2020

Full title: Utilisation of Design of Experiments Approach to Optimise Supercritical Fluid Extraction of Medicinal Cannabis

Authors: Rochfort, Simone; Isbel, Ashley; Ezernieks, Vilnis; Elkins, Aaron; Vincent, Delphine; Deseo, Myrna A.; Spangenberg, Germán

DOI: https://doi.org/10.1038/s41598-020-66119-1

Paper

Optimization of an O2-balanced bioartificial pancreas for type 1 diabetes using statistical design of experiment.

Mouré, Anne; Bekir, Sawsen; Bacou, Elodie et al. · 2022

Full title: Optimization of an O2-balanced bioartificial pancreas for type 1 diabetes using statistical design of experiment.

DOI: https://doi.org/10.1038/s41598-022-07887-w

Paper

Development of a zinc-enriched yeast strain for nutritional applications using low-cost ingredients

Pegah Zare; Minoo Giyahchi; Tabasom Entezari et al. · 2025

Full title: Development of a zinc-enriched yeast strain for nutritional applications using low-cost ingredients

Authors: Pegah Zare; Minoo Giyahchi; Tabasom Entezari; Hamid Moghimi

DOI: https://doi.org/10.1038/s41598-025-26371-9

Paper

A Design of Experiments (DoE) Approach Accelerates the Optimization of Copper-Mediated 18F-Fluorination Reactions of Arylstannanes.

Bowden, Gregory D; Pichler, Bernd J; Maurer, Andreas · 2019

Full title: A Design of Experiments (DoE) Approach Accelerates the Optimization of Copper-Mediated 18F-Fluorination Reactions of Arylstannanes.

Authors: Bowden, Gregory D; Pichler, Bernd J; Maurer, Andreas

DOI: https://doi.org/10.1038/s41598-019-47846-6

Paper

A pre-formulation study of tetracaine loaded in optimized nanostructured lipid carriers.

Castro, Simone R; Ribeiro, Lígia N M; Breitkreitz, Márcia C et al. · 2021

Full title: A pre-formulation study of tetracaine loaded in optimized nanostructured lipid carriers.

DOI: https://doi.org/10.1038/s41598-021-99743-6

Paper

Quality by design approach identifies critical parameters driving oxygen delivery performance in vitro for perfluorocarbon based artificial oxygen carriers.

Lambert, Eric; Janjic, Jelena M · 2021

Full title: Quality by design approach identifies critical parameters driving oxygen delivery performance in vitro for perfluorocarbon based artificial oxygen carriers.

Authors: Lambert, Eric; Janjic, Jelena M

DOI: https://doi.org/10.1038/s41598-021-84076-1

Paper

Numerical parametric optimization of fluid flow profiles in membranes using the Taguchi method.

Arslan, Muhammad; Xian, Haizhen; Shah, Imran et al. · 2025

Full title: Numerical parametric optimization of fluid flow profiles in membranes using the Taguchi method.

Authors: Arslan, Muhammad; Xian, Haizhen; Shah, Imran; Aziz, Shahid; Jung, Dong-Won

DOI: https://doi.org/10.1038/s41598-025-19792-z

Paper

Design of experiments as a tool to guide the preparation of tailor-made activated carbons.

Schaubeder, Jana B; Guizani, Chamseddine; Selinger, Julian et al. · 2023

Full title: Design of experiments as a tool to guide the preparation of tailor-made activated carbons.

Authors: Schaubeder, Jana B; Guizani, Chamseddine; Selinger, Julian; Mautner, Andreas; Hummel, Michael; Spirk, Stefan

DOI: https://doi.org/10.1038/s41598-023-30642-8

Paper

Valorization of wood waste for enhanced polyhydroxybutyrate production by Klebsiella sp. MK3.

Kumar, Mukesh; Sachan, Rohan Samir Kumar; Karnwal, Arun et al. · 2025

Full title: Valorization of wood waste for enhanced polyhydroxybutyrate production by Klebsiella sp. MK3.

Authors: Kumar, Mukesh; Sachan, Rohan Samir Kumar; Karnwal, Arun; Sur, Dharmesh; Thakur, Rahul; Kumar, Abhinav; Manickkam, Sathiyamoorthy; Ayanie, Abinet Gosaye; Almujibah, Hamad

DOI: https://doi.org/10.1038/s41598-025-01305-7

Paper

A new evidence-based design-of-experiments approach for optimizing drug delivery systems with exemplification by emulsion-derived Vancomycin-loaded PLGA capsules.

Namdar, Ashkan; Borhanzadeh, Tina; Salahinejad, Erfan · 2024

Full title: A new evidence-based design-of-experiments approach for optimizing drug delivery systems with exemplification by emulsion-derived Vancomycin-loaded PLGA capsules.

Authors: Namdar, Ashkan; Borhanzadeh, Tina; Salahinejad, Erfan

DOI: https://doi.org/10.1038/s41598-024-82496-3

Paper

A multi-stage lithium-ion battery aging dataset using various experimental design methodologies.

Stroebl, Florian; Petersohn, Ronny; Schricker, Barbara et al. · 2024

Full title: A multi-stage lithium-ion battery aging dataset using various experimental design methodologies.

Authors: Stroebl, Florian; Petersohn, Ronny; Schricker, Barbara; Schaeufl, Florian; Bohlen, Oliver; Palm, Herbert

DOI: https://doi.org/10.1038/s41597-024-03859-z

Paper

Single and multi-objective real-time optimisation of an industrial injection moulding process via a Bayesian adaptive design of experiment approach.

Kariminejad, Mandana; Tormey, David; Ryan, Caitríona et al. · 2024

Full title: Single and multi-objective real-time optimisation of an industrial injection moulding process via a Bayesian adaptive design of experiment approach.

Authors: Kariminejad, Mandana; Tormey, David; Ryan, Caitríona; O'Hara, Christopher; Weinert, Albert; McAfee, Marion

DOI: https://doi.org/10.1038/s41598-024-80405-2

Paper

AutoML based workflow for design of experiments (DOE) selection and benchmarking data acquisition strategies with simulation models.

Xu, Xukuan; Li, Donghui; Bi, Jinghou et al. · 2024

Full title: AutoML based workflow for design of experiments (DOE) selection and benchmarking data acquisition strategies with simulation models.

Authors: Xu, Xukuan; Li, Donghui; Bi, Jinghou; Moeckel, Michael

DOI: https://doi.org/10.1038/s41598-024-83581-3

Paper

Intelligent information management enables quality-by-design in pharmaceutical production.

Zhu, Zihan · 2025

Full title: Intelligent information management enables quality-by-design in pharmaceutical production.

Authors: Zhu, Zihan

DOI: https://doi.org/10.1038/s41598-025-27879-w

Paper

Design framework and optimization of portable biomedical waste decomposition systems using ANN and MOPSO.

Bhaiswar, Naresh N; Satputaley, Sushant S; Kadam, Sandeep M et al. · 2025

Full title: Design framework and optimization of portable biomedical waste decomposition systems using ANN and MOPSO.

Authors: Bhaiswar, Naresh N; Satputaley, Sushant S; Kadam, Sandeep M; Dinesha, P; Mohan, Sooraj

DOI: https://doi.org/10.1038/s41598-025-33723-y

Paper

Systematic optimization of human pluripotent stem cells media using Design of Experiments.

Marinho, Paulo A; Chailangkarn, Thanathom; Muotri, Alysson R · 2015

Full title: Systematic optimization of human pluripotent stem cells media using Design of Experiments.

Authors: Marinho, Paulo A; Chailangkarn, Thanathom; Muotri, Alysson R

DOI: https://doi.org/10.1038/srep09834

Paper

DOE Optimization of Nano-based Carrier of Pregabalin as Hydrogel: New Therapeutic &Chemometric Approaches for Controlled Drug Delivery Systems.

Arafa, Mona G; Ayoub, Bassam M · 2017

Full title: DOE Optimization of Nano-based Carrier of Pregabalin as Hydrogel: New Therapeutic &Chemometric Approaches for Controlled Drug Delivery Systems.

Authors: Arafa, Mona G; Ayoub, Bassam M

DOI: https://doi.org/10.1038/srep41503

Paper

Multi-response optimization of defined and undefined serum-free media for enhanced proliferation of immortalized lamb muscle cells.

Amirvaresi, Arian; Ovissipour, Reza · 2025

Full title: Multi-response optimization of defined and undefined serum-free media for enhanced proliferation of immortalized lamb muscle cells.

Authors: Amirvaresi, Arian; Ovissipour, Reza

DOI: https://doi.org/10.1038/s41598-025-27508-6

Paper

Application of a definitive screening design for the synthesis of a charge-transfer complex of sparfloxacin with tetracyanoethylene: spectroscopic, thermodynamic, kinetics, and DFT computational studies.

El-Shafie, Ahmed S; Khashan, Areej W; Hussein, Yasser H A et al. · 2019

Authors: El-Shafie, Ahmed S; Khashan, Areej W; Hussein, Yasser H A; El-Azazy, Marwa

DOI: https://doi.org/10.1039/c9ra03141c

Paper

Machine learning and molecular descriptors enable rational solvent selection in asymmetric catalysis.

Amar, Yehia; Schweidtmann, Artur M; Deutsch, Paul et al. · 2019

Full title: Machine learning and molecular descriptors enable rational solvent selection in asymmetric catalysis.

Authors: Amar, Yehia; Schweidtmann, Artur M; Deutsch, Paul; Cao, Liwei; Lapkin, Alexei

DOI: https://doi.org/10.1039/c9sc01844a

Paper

Statistical Optimization of Hydrazone-Crosslinked Hyaluronic Acid Hydrogels for Protein Delivery.

Mozipo, Esther A; Galindo, Alycia N; Khachatourian, Jenna D et al. · 2023

Full title: Statistical Optimization of Hydrazone-Crosslinked Hyaluronic Acid Hydrogels for Protein Delivery.

DOI: https://doi.org/10.1101/2023.07.14.549125

Paper

The application of design of experiments (DoE) reaction optimisation and solvent selection in the development of new synthetic chemistry.

Murray, Paul M; Bellany, Fiona; Benhamou, Laure et al. · 2016

Full title: The application of design of experiments (DoE) reaction optimisation and solvent selection in the development of new synthetic chemistry.

Authors: Murray, Paul M; Bellany, Fiona; Benhamou, Laure; Bučar, Dejan-Krešimir; Tabor, Alethea B; Sheppard, Tom D

DOI: https://doi.org/10.1039/c5ob01892g

Paper

Microfluidic synthesis of protein-loaded nanogels in a coaxial flow reactor using a design of experiments approach

Whiteley, Zoe; Ho, Hei Ming Kenneth; Gan, Yee Xin et al. · 2021

Full title: Microfluidic synthesis of protein-loaded nanogels in a coaxial flow reactor using a design of experiments approach

Authors: Whiteley, Zoe; Ho, Hei Ming Kenneth; Gan, Yee Xin; Panariello, Luca; Gkogkos, Georgios; Gavriilidis, Asterios; Craig, Duncan Q.M.

DOI: https://doi.org/10.1039/d0na01051k

Paper

Development of a fluorescence-based assay for RecBCD activity using functional data analysis and design of experiments.

Winnifrith, Adam; Brown, Steven R; Jedryszek, Piotr et al. · 2025

Full title: Development of a fluorescence-based assay for RecBCD activity using functional data analysis and design of experiments.

Authors: Winnifrith, Adam; Brown, Steven R; Jedryszek, Piotr; Grant, C; Kay, Philip E; Thomas, Adam M; Bradbury, Jacob D; Lanyon-Hogg, Thomas

DOI: https://doi.org/10.1039/d4cb00291a

Paper

Self-optimising processes and real-time-optimisation of organic syntheses in a microreactor system using Nelder–Mead and design of experiments

Fath, Verena; Kockmann, Norbert; Otto, Jürgen C. et al. · 2020

Full title: Self-optimising processes and real-time-optimisation of organic syntheses in a microreactor system using Nelder–Mead and design of experiments

Authors: Fath, Verena; Kockmann, Norbert; Otto, Jürgen C.; Röder, Thorsten

DOI: https://doi.org/10.1039/d0re00081g

Paper

PEGylated lipid screening, composition optimization, and structure-activity relationship determination for lipid nanoparticle-mediated mRNA delivery.

Liu, Lingyun; Kim, Jae-Heon; Li, Zhongyu et al. · 2025

Full title: PEGylated lipid screening, composition optimization, and structure-activity relationship determination for lipid nanoparticle-mediated mRNA delivery.

Authors: Liu, Lingyun; Kim, Jae-Heon; Li, Zhongyu; Sun, Mengwei; Northen, Trent; Tang, Jackie; Mcintosh, Emma; Karve, Shrirang; DeRosa, Frank

DOI: https://doi.org/10.1039/d5nr00433k

Paper

Harnessing data and control with AI/ML-driven polymerization and copolymerization.

Advincula, Rigoberto; Ivanov, Ilia; Vasudevan, Rama et al. · 2026

Full title: Harnessing data and control with AI/ML-driven polymerization and copolymerization.

Authors: Advincula, Rigoberto; Ivanov, Ilia; Vasudevan, Rama; Kumar, Rajeev; Christakopoulos, Panagiotis; Tsakanika, Marileta; Chen, Jihua; Carillo, Jan Michael; Zhu, Qinyu; Sumpter, Bobby

DOI: https://doi.org/10.1039/d5fd00066a

Paper

Statistical optimization of cell-hydrogel interactions for green microbiology - a tutorial review.

Harris, Conor G; Semprini, Lewis; Rochefort, Willie E et al. · 2024

Full title: Statistical optimization of cell-hydrogel interactions for green microbiology - a tutorial review.

Authors: Harris, Conor G; Semprini, Lewis; Rochefort, Willie E; Fogg, Kaitlin C

DOI: https://doi.org/10.1039/d4su00400k

Paper

The design of experiments (DoE) in optimization of an aerobic flow Pd-catalyzed oxidation of alcohol towards an important aldehyde precursor in the synthesis of phosphatidylinositide 3-kinase inhibitor (CPL302415).

Michałek, Stanisław; Gurba-Bryśkiewicz, Lidia; Maruszak, Wioleta et al. · 2022

Authors: Michałek, Stanisław; Gurba-Bryśkiewicz, Lidia; Maruszak, Wioleta; Zagozda, Marcin; Maj, Anna M; Ochal, Zbigniew; Dubiel, Krzysztof; Wieczorek, Maciej

DOI: https://doi.org/10.1039/d2ra07003k

Paper

Combination of Ultrasound with Ammonification Pretreatment for the Fiber Composition of Corn Straw: a Predictive Model by Response Surface Methodology

Xiaoli Wei; Runtao Wang; Tengyu Qu et al. · 2019

Full title: Combination of Ultrasound with Ammonification Pretreatment for the Fiber Composition of Corn Straw: a Predictive Model by Response Surface Methodology

Authors: Xiaoli Wei; Runtao Wang; Tengyu Qu; Gen li

DOI: https://doi.org/10.1088/1742-6596/1169/1/012023

Paper

Optimization of Bioleaching Process of High-Fluoride-Bearing Uranium by Response Surface Methodology

Xiang Li; Xiao-lan Mo; J. Wen et al. · 2019

Full title: Optimization of Bioleaching Process of High-Fluoride-Bearing Uranium by Response Surface Methodology

Authors: Xiang Li; Xiao-lan Mo; J. Wen; Hong-ying Yang

DOI: https://doi.org/10.1088/1757-899x/562/1/012100

Paper

Optimization of Different Parameter in Synthesis Ion Imprinted Polymers via Precipitation Polymerization for Nitrate Adsorption

Noorhidayah Ishak; Teh Chin Xin; Azalina Mohamed Nasir et al. · 2020

Full title: Optimization of Different Parameter in Synthesis Ion Imprinted Polymers via Precipitation Polymerization for Nitrate Adsorption

Authors: Noorhidayah Ishak; Teh Chin Xin; Azalina Mohamed Nasir; Shuit Siew Hoong

DOI: https://doi.org/10.1088/1757-899x/864/1/012184

Paper

Statistical optimization strategies on waste substrates for solving high-cost challenges in biosurfactants production: a review

Abimbola Bowofoluwa Sharon; E. Ahuekwe; Elughi Gift Nzubechi et al. · 2023

Full title: Statistical optimization strategies on waste substrates for solving high-cost challenges in biosurfactants production: a review

Authors: Abimbola Bowofoluwa Sharon; E. Ahuekwe; Elughi Gift Nzubechi; O. Oziegbe; M. Oniha

DOI: https://doi.org/10.1088/1755-1315/1197/1/012004

Paper

2-[(Hydroxymethyl)amino]ethanol in water as a preservative: Study of formaldehyde released by Taguchi's method

W. Wisessirikul; S. Loykulnant; S. Montha et al. · 2016

Full title: 2-[(Hydroxymethyl)amino]ethanol in water as a preservative: Study of formaldehyde released by Taguchi's method

Authors: W. Wisessirikul; S. Loykulnant; S. Montha; T. Fhulua; P. Prapainainar

DOI: https://doi.org/10.1088/1755-1315/36/1/012049

Paper

Immobilization of cyclodextrin glucanotransferase on hollow fiber membrane: optimization of the immobilization parameters by response surface methodology

N. Jamil; R. C. Man; S. Suhaimi et al. · 2019

Full title: Immobilization of cyclodextrin glucanotransferase on hollow fiber membrane: optimization of the immobilization parameters by response surface methodology

Authors: N. Jamil; R. C. Man; S. Suhaimi; S. Shaarani; Z. I. M. Arshad; S. K. A. Mudalip; S. Z. Sulaiman

DOI: https://doi.org/10.1088/1755-1315/268/1/012008

Paper

Response Surface Methodology for Optimization Studies of Microwave-assisted hydrodistillation of essential oil from Vietnamese Citrus aurantifolia (Lemon fruit)

T. Hien Tran; Tri Duc Lam; Van Tien Nguyen et al. · 2019

Full title: Response Surface Methodology for Optimization Studies of Microwave-assisted hydrodistillation of essential oil from Vietnamese Citrus aurantifolia (Lemon fruit)

Authors: T. Hien Tran; Tri Duc Lam; Van Tien Nguyen; Tan Phat Dao; Le Thi Hong Nhan; Tran Quoc Toan; D. Vo; Tran Anh Vy; L. M. Bui

DOI: https://doi.org/10.1088/1757-899x/542/1/012042

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Application of response surface methodology in optimization condition of anthocyanin extraction process of cocoa peel waste with Microwave Assisted Extraction Method (MAE)

I. Rahmawati; B. A. Fachri; Y. Manurung et al. · 2021

Full title: Application of response surface methodology in optimization condition of anthocyanin extraction process of cocoa peel waste with Microwave Assisted Extraction Method (MAE)

Authors: I. Rahmawati; B. A. Fachri; Y. Manurung; Nurtsulutsiyah; M. Reza

DOI: https://doi.org/10.1088/1755-1315/743/1/012091

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Optimization of the Extraction Process of Anti-Vibrio parahaemolyticus Active Substances from Coptidis Rhizoma (Huanglian)

Xintong Wang; Siya Guo; Zongyi Zhang et al. · 2020

Full title: Optimization of the Extraction Process of Anti-Vibrio parahaemolyticus Active Substances from Coptidis Rhizoma (Huanglian)

Authors: Xintong Wang; Siya Guo; Zongyi Zhang; Qian Xu; Lei Guo

DOI: https://doi.org/10.1088/1742-6596/1637/1/012108

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A design of experiments approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies.

Ruiter, F A A; Alexander, C; Rose, F R A J et al. · 2017

Full title: A design of experiments approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies.

Authors: Ruiter, F A A; Alexander, C; Rose, F R A J; Segal, J I

DOI: https://doi.org/10.1088/1748-605X/aa7b54

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Statistical Optimization of Hydrazone-Crosslinked Hyaluronic Acid Hydrogels for Protein Delivery.

Mozipo, Esther A; Galindo, Alycia N; Khachatourian, Jenna D et al. · 2023

Full title: Statistical Optimization of Hydrazone-Crosslinked Hyaluronic Acid Hydrogels for Protein Delivery.

DOI: https://doi.org/10.1101/2023.07.14.549125

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A dynamic method for the investigation of induced state metabolic capacities as a function of temperature.

Sagmeister, Patrick; Langemann, Timo; Wechselberger, Patrick et al. · 2013

Full title: A dynamic method for the investigation of induced state metabolic capacities as a function of temperature.

Authors: Sagmeister, Patrick; Langemann, Timo; Wechselberger, Patrick; Meitz, Andrea; Herwig, Christoph

DOI: https://doi.org/10.1186/1475-2859-12-94

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Optimisation of the synthesis of vancomycin-selective molecularly imprinted polymer nanoparticles using automatic photoreactor.

Muzyka, Kateryna; Karim, Khalku; Guerreiro, Antonio et al. · 2014

Full title: Optimisation of the synthesis of vancomycin-selective molecularly imprinted polymer nanoparticles using automatic photoreactor.

Authors: Muzyka, Kateryna; Karim, Khalku; Guerreiro, Antonio; Poma, Alessandro; Piletsky, Sergey

DOI: https://doi.org/10.1186/1556-276X-9-154

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Enhancing nitrilase production from Fusarium proliferatum using response surface methodology.

Yusuf, Farnaz; Chaubey, Asha; Raina, Arvind et al. · 2013

Full title: Enhancing nitrilase production from Fusarium proliferatum using response surface methodology.

Authors: Yusuf, Farnaz; Chaubey, Asha; Raina, Arvind; Jamwal, Urmila; Parshad, Rajinder

DOI: https://doi.org/10.1186/2193-1801-2-290

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Optimization of ultrasonic extraction of polysaccharides from Ziziphus jujuba Mill. by response surface methodology.

Qu, Chenling; Yu, Songcheng; Luo, Li et al. · 2013

Full title: Optimization of ultrasonic extraction of polysaccharides from Ziziphus jujuba Mill. by response surface methodology.

Authors: Qu, Chenling; Yu, Songcheng; Luo, Li; Zhao, Yan; Huang, Yawei

DOI: https://doi.org/10.1186/1752-153X-7-160

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Optimization of protein production by Micrococcus luteus for exploring pollutant-degrading uncultured bacteria.

Su, Xiaomei; Liu, Yindong; Hu, Jinxing et al. · 2014

Full title: Optimization of protein production by Micrococcus luteus for exploring pollutant-degrading uncultured bacteria.

Authors: Su, Xiaomei; Liu, Yindong; Hu, Jinxing; Ding, Linxian; Shen, Chaofeng

DOI: https://doi.org/10.1186/2193-1801-3-117

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Developing a scalable model of recombinant protein yield from Pichia pastoris: the influence of culture conditions, biomass and induction regime.

Holmes, William J; Darby, Richard Aj; Wilks, Martin Db et al. · 2009

Full title: Developing a scalable model of recombinant protein yield from Pichia pastoris: the influence of culture conditions, biomass and induction regime.

Authors: Holmes, William J; Darby, Richard Aj; Wilks, Martin Db; Smith, Rodney; Bill, Roslyn M

DOI: https://doi.org/10.1186/1475-2859-8-35

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Influência de diferentes meios de cultura em cultivos de Streptococcus pneumoniae sorotipo 1 para produção de polissacarídeo capsular.

Bruno Vitório Marthos · 2012

Full title: Influência de diferentes meios de cultura em cultivos de Streptococcus pneumoniae sorotipo 1 para produção de polissacarídeo capsular.

Authors: Bruno Vitório Marthos

DOI: https://doi.org/10.11606/d.87.2012.tde-30102012-161733

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Enhanced cell disruption strategy in the release of recombinant hepatitis B surface antigen from Pichia pastoris using response surface methodology

Y. J. Tam; Z. Allaudin; M. Lila et al. · 2012

Full title: Enhanced cell disruption strategy in the release of recombinant hepatitis B surface antigen from Pichia pastoris using response surface methodology

Authors: Y. J. Tam; Z. Allaudin; M. Lila; A. R. Bahaman; J. Tan; M. Rezaei

DOI: https://doi.org/10.1186/1472-6750-12-70

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Optimization of production of the anti-keratin 8 single-chain Fv TS1-218 in Pichia pastoris using design of experiments

Jafari, Rozbeh; Sundström, Birgitta; Holm, Patrik · 2011

Full title: Optimization of production of the anti-keratin 8 single-chain Fv TS1-218 in Pichia pastoris using design of experiments

Authors: Jafari, Rozbeh; Sundström, Birgitta; Holm, Patrik

DOI: https://doi.org/10.1186/1475-2859-10-34

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Climbing the mountain: experimental design for the efficient optimization of stem cell bioprocessing.

Toms, Derek; Deardon, Rob; Ungrin, Mark · 2017

Full title: Climbing the mountain: experimental design for the efficient optimization of stem cell bioprocessing.

Authors: Toms, Derek; Deardon, Rob; Ungrin, Mark

DOI: https://doi.org/10.1186/s13036-017-0078-z

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Optimization of a recombinant BlaR-CTD protein formulation using the response surface methodology.

Abdolvahab, Mohadeseh Haji; Safari, Mojdeh; Hasannejad, Farkhonde et al. · 2024

Full title: Optimization of a recombinant BlaR-CTD protein formulation using the response surface methodology.

Authors: Abdolvahab, Mohadeseh Haji; Safari, Mojdeh; Hasannejad, Farkhonde; Asefi, Nika; Salimi, Alireza; Nazari, Mahboobeh

DOI: https://doi.org/10.1186/s13036-023-00399-9

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Improved production of andrimid in Erwinia persicina BST187 strain by fermentation optimization.

Cheng, Tingfeng; Ge, Tongling; Zhao, Lunqiang et al. · 2023

Full title: Improved production of andrimid in Erwinia persicina BST187 strain by fermentation optimization.

Authors: Cheng, Tingfeng; Ge, Tongling; Zhao, Lunqiang; Hou, Yuyong; Xia, Jianye; Zhao, Lei

DOI: https://doi.org/10.1186/s12866-023-02946-2

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Use of a design of experiments approach to optimise production of a recombinant antibody fragment in the periplasm of Escherichia coli: selection of signal peptide and optimal growth conditions.

Kasli, Ikhlaas M; Thomas, Owen R T; Overton, Tim W · 2019

Authors: Kasli, Ikhlaas M; Thomas, Owen R T; Overton, Tim W

DOI: https://doi.org/10.1186/s13568-018-0727-8

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Cell factory for γ-aminobutyric acid (GABA) production using Bifidobacterium adolescentis

Hend Altaib; Tomoya Kozakai; Y. Badr et al. · 2022

Full title: Cell factory for γ-aminobutyric acid (GABA) production using Bifidobacterium adolescentis

Authors: Hend Altaib; Tomoya Kozakai; Y. Badr; Hazuki Nakao; Mahmoud A. M. El-Nouby; Emiko Yanase; Izumi Nomura; Tohru Suzuki

DOI: https://doi.org/10.1186/s12934-021-01729-6

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Optimal process design space to ensure maximum viability and productivity in Penicillium chrysogenum pellets during fed-batch cultivations through morphological and physiological control.

Veiter, Lukas; Kager, Julian; Herwig, Christoph · 2020

Full title: Optimal process design space to ensure maximum viability and productivity in Penicillium chrysogenum pellets during fed-batch cultivations through morphological and physiological control.

Authors: Veiter, Lukas; Kager, Julian; Herwig, Christoph

DOI: https://doi.org/10.1186/s12934-020-1288-5

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Optimization of tenocyte lineage-related factors from tonsil-derived mesenchymal stem cells using response surface methodology.

Kwon, Soon-Sun; Kim, Hyang; Shin, Sang-Jin et al. · 2020

Full title: Optimization of tenocyte lineage-related factors from tonsil-derived mesenchymal stem cells using response surface methodology.

Authors: Kwon, Soon-Sun; Kim, Hyang; Shin, Sang-Jin; Lee, Seung Yeol

DOI: https://doi.org/10.1186/s13018-020-01623-8

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Optimization of medium compositions to improve a novel glycoprotein production by Streptomyces kanasenisi ZX01.

Zhou, Yong; Sun, Yu-Bo; He, Hong-Wei et al. · 2017

Full title: Optimization of medium compositions to improve a novel glycoprotein production by Streptomyces kanasenisi ZX01.

Authors: Zhou, Yong; Sun, Yu-Bo; He, Hong-Wei; Feng, Jun-Tao; Zhang, Xing; Han, Li-Rong

DOI: https://doi.org/10.1186/s13568-016-0316-7

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Optimization of laccase production from Marasmiellus palmivorus LA1 by Taguchi method of Design of experiments.

Chenthamarakshan, Aiswarya; Parambayil, Nayana; Miziriya, Nafeesathul et al. · 2017

Full title: Optimization of laccase production from Marasmiellus palmivorus LA1 by Taguchi method of Design of experiments.

Authors: Chenthamarakshan, Aiswarya; Parambayil, Nayana; Miziriya, Nafeesathul; Soumya, P S; Lakshmi, M S Kiran; Ramgopal, Anala; Dileep, Anuja; Nambisan, Padma

DOI: https://doi.org/10.1186/s12896-017-0333-x

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Modeling the dependence of respiration and photosynthesis upon light, acetate, carbon dioxide, nitrate and ammonium in Chlamydomonas reinhardtii using design of experiments and multiple regression.

Gérin, Stéphanie; Mathy, Grégory; Franck, Fabrice · 2014

Authors: Gérin, Stéphanie; Mathy, Grégory; Franck, Fabrice

DOI: https://doi.org/10.1186/s12918-014-0096-0

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Combinatorial engineering pinpoints shikimate pathway bottlenecks in para-aminobenzoic acid production in Pseudomonas putida.

Campos-Magaña, Marco A; Moreno-Paz, Sara; Martin-Pascual, Maria et al. · 2025

Full title: Combinatorial engineering pinpoints shikimate pathway bottlenecks in para-aminobenzoic acid production in Pseudomonas putida.

Authors: Campos-Magaña, Marco A; Moreno-Paz, Sara; Martin-Pascual, Maria; Martins Dos Santos, Vitor Ap; Garcia-Morales, Luis; Suarez-Diez, Maria

DOI: https://doi.org/10.1186/s13036-025-00553-5

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Screening for efficient nitrogen sources for overproduction of the biomass of the functionally probiotic L. plantarum strain RPR42 in a cane molasses-based medium.

Papizadeh, Moslem; Rohani, Mahdi; Hosseini, Seyed Nezamedin et al. · 2020

Full title: Screening for efficient nitrogen sources for overproduction of the biomass of the functionally probiotic L. plantarum strain RPR42 in a cane molasses-based medium.

Authors: Papizadeh, Moslem; Rohani, Mahdi; Hosseini, Seyed Nezamedin; Shojaosadati, Seyed Abbas; Nahrevanian, Hossein; Talebi, Malihe; Pourshafie, Mohammad Reza

DOI: https://doi.org/10.1186/s13568-020-00976-x

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A numerical compass for experiment design in chemical kinetics and molecular property estimation.

Krüger, Matteo; Mishra, Ashmi; Spichtinger, Peter et al. · 2024

Full title: A numerical compass for experiment design in chemical kinetics and molecular property estimation.

Authors: Krüger, Matteo; Mishra, Ashmi; Spichtinger, Peter; Pöschl, Ulrich; Berkemeier, Thomas

DOI: https://doi.org/10.1186/s13321-024-00825-0

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Optimization and characterization of spray-dried IgG formulations: a design of experiment approach

Faghihi, Homa; Najafabadi, Abdolhosein Rouholamini; Vatanara, Alireza · 2017

Full title: Optimization and characterization of spray-dried IgG formulations: a design of experiment approach

Authors: Faghihi, Homa; Najafabadi, Abdolhosein Rouholamini; Vatanara, Alireza

DOI: https://doi.org/10.1186/s40199-017-0187-8

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Addressing bioreactor hiPSC aggregate stability, maintenance and scaleup challenges using a design of experiment approach.

Yehya, Haneen; Raudins, Sofija; Padmanabhan, Roshan et al. · 2024

Full title: Addressing bioreactor hiPSC aggregate stability, maintenance and scaleup challenges using a design of experiment approach.

Authors: Yehya, Haneen; Raudins, Sofija; Padmanabhan, Roshan; Jensen, Jan; Bukys, Michael A

DOI: https://doi.org/10.1186/s13287-024-03802-4

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Optimising environmental factors for maximal lactate productivity in Synechocystis sp. PCC 6803 through a design of experiments approach.

Faulkner, Matthew; Andrews, Fraser; Scrutton, Nigel S · 2025

Full title: Optimising environmental factors for maximal lactate productivity in Synechocystis sp. PCC 6803 through a design of experiments approach.

Authors: Faulkner, Matthew; Andrews, Fraser; Scrutton, Nigel S

DOI: https://doi.org/10.1186/s13068-025-02718-2

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Design of experiments to assess the effect of culture parameters on the osteogenic differentiation of human adipose stromal cells.

Kuterbekov, Mirasbek; Machillot, Paul; Baillet, Francis et al. · 2019

Full title: Design of experiments to assess the effect of culture parameters on the osteogenic differentiation of human adipose stromal cells.

Authors: Kuterbekov, Mirasbek; Machillot, Paul; Baillet, Francis; Jonas, Alain M; Glinel, Karine; Picart, Catherine

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Full title: Indirect optimization of staphylokinase expression level in dicistronic auto-inducible system.

Authors: Shariati, Fatemeh Sadat; Keramati, Malihe; Cohan, Reza Ahangari

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Full title: Effective flow-through polishing strategies for knob-into-hole bispecific antibodies.

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Full title: Preparation, Characterization, and Optimization of Folic Acid-Chitosan-Methotrexate Core-Shell Nanoparticles by Box-Behnken Design for Tumor-Targeted Drug Delivery.

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Full title: Statistical modeling, optimization and characterization of spray-dried solid self-microemulsifying drug delivery system using design of experiments.

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Full title: Optimization of Low-Temperature Methanol Crystallization for Unsaturated Fatty Acids Separation from Crude Palm Fatty Acids Mixture Using Response Surface Methodology

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RECURSIVE CO-KRIGING MODEL FOR DESIGN OF COMPUTER EXPERIMENTS WITH MULTIPLE LEVELS OF FIDELITY

Gratiet, Loïc Le; Garnier, Josselin · 2014

Full title: RECURSIVE CO-KRIGING MODEL FOR DESIGN OF COMPUTER EXPERIMENTS WITH MULTIPLE LEVELS OF FIDELITY

Authors: Gratiet, Loïc Le; Garnier, Josselin

DOI: https://doi.org/10.1615/int.j.uncertaintyquantification.2014006914

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Encapsulation of Eucalyptus tereticornis extract in polylactic-co-glycolic acid nanoparticles: standardization, optimization and cell viability.

Maria C Cely-Garcia; Diana Y Espinel-Pabón; Nancy Jaimes-Mendez et al. · 2025

Full title: Encapsulation of Eucalyptus tereticornis extract in polylactic-co-glycolic acid nanoparticles: standardization, optimization and cell viability.

Authors: Maria C Cely-Garcia; Diana Y Espinel-Pabón; Nancy Jaimes-Mendez; Norman Balcazar-Morales; Edwin A Murillo-Ruiz

DOI: https://doi.org/10.1590/0001-3765202520241069

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Design of Experiments (DoE) applied to Pharmaceutical and Analytical Quality by Design (QbD)

Fukuda, Isa Martins; Pinto, Camila Francini Fidelis; Moreira, Camila dos Santos et al. · 2018

Full title: Design of Experiments (DoE) applied to Pharmaceutical and Analytical Quality by Design (QbD)

Authors: Fukuda, Isa Martins; Pinto, Camila Francini Fidelis; Moreira, Camila dos Santos; Saviano, Alessandro Morais; Lourenço, Felipe Rebello

DOI: https://doi.org/10.1590/s2175-97902018000001006

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Application of statistical experimental design for optimisation of bioinsecticides production by sporeless Bacillus thuringiensis strain on cheap medium.

Ben Khedher, Saoussen; Jaoua, Samir; Zouari, Nabil · 2013

Full title: Application of statistical experimental design for optimisation of bioinsecticides production by sporeless Bacillus thuringiensis strain on cheap medium.

Authors: Ben Khedher, Saoussen; Jaoua, Samir; Zouari, Nabil

DOI: https://doi.org/10.1590/s1517-83822013000300043

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Effect of Extraction Conditions of Green Tea on Antioxidant Activity and EGCG Content: Optimization using Response Surface Methodology

Mun Jun Kim; J. Ahn; S. Kim et al. · 2016

Full title: Effect of Extraction Conditions of Green Tea on Antioxidant Activity and EGCG Content: Optimization using Response Surface Methodology

Authors: Mun Jun Kim; J. Ahn; S. Kim; Y. Jo; Qing Liu; B. Hwang; M. Lee

DOI: https://doi.org/10.20307/nps.2016.22.4.270

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Data-Driven Process Optimization Using AI and Statistical Methods in High-Tech Manufacturing

Gaurav Rajendra Parashare · 2024

Full title: Data-Driven Process Optimization Using AI and Statistical Methods in High-Tech Manufacturing

Authors: Gaurav Rajendra Parashare

DOI: https://doi.org/10.18535/ijsrm/v12i12.ec09

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Developing a Cell Culture Protocol to Induce Quiescence in Intestinal Fibroblasts Using Design of Experiments Statistical Optimization.

Mohammadalizadeh, Zahra; Estrada, Katherine Bauer; Almonte, Morgenne et al. · 2025

Full title: Developing a Cell Culture Protocol to Induce Quiescence in Intestinal Fibroblasts Using Design of Experiments Statistical Optimization.

Authors: Mohammadalizadeh, Zahra; Estrada, Katherine Bauer; Almonte, Morgenne; Fogg, Kaitlin C; Porras, Ana M

DOI: https://doi.org/10.21203/rs.3.rs-7677632/v1

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Development of a thermostable nanoemulsion adjuvanted vaccine against tuberculosis using a design-of-experiments approach

Kramer, Ryan M.; Archer, Michelle; Orr, Mark T. et al. · 2018

Full title: Development of a thermostable nanoemulsion adjuvanted vaccine against tuberculosis using a design-of-experiments approach

DOI: https://doi.org/10.2147/ijn.s159839

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DESIGN OF EXPERIMENTS MODEL FOR THE OPTIMIZATION OF SILK FIBROIN BASED NANOPARTICLES

Phạm, Duy Toàn; Saelim, Nuttawut; Tiyaboonchai, Waree · 2018

Full title: DESIGN OF EXPERIMENTS MODEL FOR THE OPTIMIZATION OF SILK FIBROIN BASED NANOPARTICLES

Authors: Phạm, Duy Toàn; Saelim, Nuttawut; Tiyaboonchai, Waree

DOI: https://doi.org/10.22159/ijap.2018v10i5.28139

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The outline of the expert system for the design of experiment

Dwornicka, Renata; Pietraszek, Jacek · 2018

Full title: The outline of the expert system for the design of experiment

Authors: Dwornicka, Renata; Pietraszek, Jacek

DOI: https://doi.org/10.30657/pea.2018.20.09

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Biostoning of textile effluent with laccase enzyme

K. Iqbal; A. Nadeem; U. Zafar · 2021

Full title: Biostoning of textile effluent with laccase enzyme

Authors: K. Iqbal; A. Nadeem; U. Zafar

DOI: https://doi.org/10.3329/bjsir.v56i2.54318

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An Alternative Perfusion Approach for the Intensification of Virus-Like Particle Production in HEK293 Cultures.

Lavado-García, Jesús; Cervera, Laura; Gòdia, Francesc · 2020

Full title: An Alternative Perfusion Approach for the Intensification of Virus-Like Particle Production in HEK293 Cultures.

Authors: Lavado-García, Jesús; Cervera, Laura; Gòdia, Francesc

DOI: https://doi.org/10.3389/fbioe.2020.00617

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One-Time Optimization of Advanced T Cell Culture Media Using a Machine Learning Pipeline.

Grzesik, Paul; Warth, Sebastian C · 2021

Full title: One-Time Optimization of Advanced T Cell Culture Media Using a Machine Learning Pipeline.

Authors: Grzesik, Paul; Warth, Sebastian C

DOI: https://doi.org/10.3389/fbioe.2021.614324

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Modeling and Optimization of Propane Selective Oxidation to Acrylic Acid Over Mo 1 V 0.3 Te 0.23 NB 0.12 O X Catalyst Using Artificial Neural Network and Box-Behnken Design

Golshan Mazloom · 2020

Full title: Modeling and Optimization of Propane Selective Oxidation to Acrylic Acid Over Mo 1 V 0.3 Te 0.23 NB 0.12 O X Catalyst Using Artificial Neural Network and Box-Behnken Design

Authors: Golshan Mazloom

DOI: https://doi.org/10.3329/cerb.v21i1.47368

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Biosynthesis of Silver Nanoparticles by Aspergillus terreus: Characterization, Optimization, and Biological Activities.

Lotfy, Walid A; Alkersh, Basma M; Sabry, Soraya A et al. · 2021

Full title: Biosynthesis of Silver Nanoparticles by Aspergillus terreus: Characterization, Optimization, and Biological Activities.

Authors: Lotfy, Walid A; Alkersh, Basma M; Sabry, Soraya A; Ghozlan, Hanan A

DOI: https://doi.org/10.3389/fbioe.2021.633468

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DoE-based medium optimization for improved biosurfactant production with Aureobasidium pullulans.

Haala, Frederick; Dielentheis-Frenken, Marie R E; Brandt, Friedrich M et al. · 2024

Full title: DoE-based medium optimization for improved biosurfactant production with Aureobasidium pullulans.

Authors: Haala, Frederick; Dielentheis-Frenken, Marie R E; Brandt, Friedrich M; Karmainski, Tobias; Blank, Lars M; Tiso, Till

DOI: https://doi.org/10.3389/fbioe.2024.1379707

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Media formulation using statistical methodology to enhance α-amylase production for green synthesis of Au-NPs by Bacillus subtilis VSP4 under solid-state fermentation.

Prajapati, Vimalkumar S; Mehta, Vaibhavkumar N; Patel, Swati K · 2025

Full title: Media formulation using statistical methodology to enhance α-amylase production for green synthesis of Au-NPs by Bacillus subtilis VSP4 under solid-state fermentation.

Authors: Prajapati, Vimalkumar S; Mehta, Vaibhavkumar N; Patel, Swati K

DOI: https://doi.org/10.3389/fbioe.2025.1569902

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Using design of experiments (DoE) to optimize performance and stability of biomimetic cell membrane-coated nanostructures for cancer therapy.

Ferreira, Natália Noronha; Miranda, Renata Rank; Moreno, Natália Sanchez et al. · 2023

Full title: Using design of experiments (DoE) to optimize performance and stability of biomimetic cell membrane-coated nanostructures for cancer therapy.

DOI: https://doi.org/10.3389/fbioe.2023.1120179

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Process Characterization by Definitive Screening Design Approach on DNA Vaccine Production.

Hocharoen, Lalintip; Noppiboon, Sarawuth; Kitsubun, Panit · 2020

Full title: Process Characterization by Definitive Screening Design Approach on DNA Vaccine Production.

Authors: Hocharoen, Lalintip; Noppiboon, Sarawuth; Kitsubun, Panit

DOI: https://doi.org/10.3389/fbioe.2020.574809

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Towards the Experimentally-Informed In Silico Nozzle Design Optimization for Extrusion-Based Bioprinting of Shear-Thinning Hydrogels.

Reina-Romo, Esther; Mandal, Sourav; Amorim, Paulo et al. · 2021

Full title: Towards the Experimentally-Informed In Silico Nozzle Design Optimization for Extrusion-Based Bioprinting of Shear-Thinning Hydrogels.

Authors: Reina-Romo, Esther; Mandal, Sourav; Amorim, Paulo; Bloemen, Veerle; Ferraris, Eleonora; Geris, Liesbet

DOI: https://doi.org/10.3389/fbioe.2021.701778

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Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments.

Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald et al. · 2021

Full title: Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments.

Authors: Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald; Sissolak, Bernhard

DOI: https://doi.org/10.3389/fbioe.2021.740215

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Micronutrient optimization for tissue engineered articular cartilage production of type II collagen.

Cruz, Maria A; Gonzalez, Yamilet; Vélez Toro, Javier A et al. · 2023

Full title: Micronutrient optimization for tissue engineered articular cartilage production of type II collagen.

DOI: https://doi.org/10.3389/fbioe.2023.1179332

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Perfusion process with tangential flow filtration for oncolytic VSV-GP production.

Hamusics, Orsolya; Wittmann, Anja; Hasler, Katrin et al. · 2025

Full title: Perfusion process with tangential flow filtration for oncolytic VSV-GP production.

Authors: Hamusics, Orsolya; Wittmann, Anja; Hasler, Katrin; Müller, Sabrina; Birk, Daniel; Gorr, Ingo H; Brix, Alexander; Soza-Ried, Jorge

DOI: https://doi.org/10.3389/fbioe.2025.1588293

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Enabling and improving trans-nerolidol production by Corynebacterium glutamicum: combining metabolic engineering and trace elements medium refinement.

Seeger, Jan; Lohoff, Stella; Schmitfranz, Fabian et al. · 2025

Full title: Enabling and improving trans-nerolidol production by Corynebacterium glutamicum: combining metabolic engineering and trace elements medium refinement.

Authors: Seeger, Jan; Lohoff, Stella; Schmitfranz, Fabian; Henke, Nadja A; Wendisch, Volker F

DOI: https://doi.org/10.3389/fbioe.2025.1621955

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Optimization of Monascus purpureus for Natural Food Pigments Production on Potato Wastes and Their Application in Ice Lolly

Hossam E. F. Abdel-Raheam; S. Alrumman; S. Gadow et al. · 2022

Full title: Optimization of Monascus purpureus for Natural Food Pigments Production on Potato Wastes and Their Application in Ice Lolly

Authors: Hossam E. F. Abdel-Raheam; S. Alrumman; S. Gadow; M. El-Sayed; Dalia M. Hikal; A. Hesham; Maysa M. A. Ali

DOI: https://doi.org/10.3389/fmicb.2022.862080

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High-throughput optimization of antibody production in CHO cells by tuning heavy- and light-chain promoter strength.

Rahimi, Marzia; Adams, Anna Christina; Grav, Lise M et al. · 2025

Full title: High-throughput optimization of antibody production in CHO cells by tuning heavy- and light-chain promoter strength.

Authors: Rahimi, Marzia; Adams, Anna Christina; Grav, Lise M; Nielsen, Lars K; Lavado-García, Jesús

DOI: https://doi.org/10.3389/fbioe.2025.1747473

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Highly Efficient One-Step Protein Immobilization on Polymer Membranes Supported by Response Surface Methodology.

Schmidt, Martin; Abdul Latif, Amira; Prager, Andrea et al. · 2021

Full title: Highly Efficient One-Step Protein Immobilization on Polymer Membranes Supported by Response Surface Methodology.

Authors: Schmidt, Martin; Abdul Latif, Amira; Prager, Andrea; Gläser, Roger; Schulze, Agnes

DOI: https://doi.org/10.3389/fchem.2021.804698

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Optimizing a Multi-Component Intranasal Entamoeba Histolytica Vaccine Formulation Using a Design of Experiments Strategy.

Abhyankar, Mayuresh M; Orr, Mark T; Kinsey, Robert et al. · 2021

Full title: Optimizing a Multi-Component Intranasal Entamoeba Histolytica Vaccine Formulation Using a Design of Experiments Strategy.

DOI: https://doi.org/10.3389/fimmu.2021.683157

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Non-edible Oil Cakes as a Novel Substrate for DPA Production and Augmenting Biocontrol Activity of Paecilomyces variotii.

Arora, Kalpana; Sharma, Satyawati; Krishna, Suresh B N et al. · 2017

Full title: Non-edible Oil Cakes as a Novel Substrate for DPA Production and Augmenting Biocontrol Activity of Paecilomyces variotii.

Authors: Arora, Kalpana; Sharma, Satyawati; Krishna, Suresh B N; Adam, Jamila K; Kumar, Ashwani

DOI: https://doi.org/10.3389/fmicb.2017.00753

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Optimizing microwave-assisted extraction of ursolic acid from apple pomace using response surface methodology

Xiyun Sun; Wenjian Zhang; Xianjun Meng et al. · 2025

Full title: Optimizing microwave-assisted extraction of ursolic acid from apple pomace using response surface methodology

Authors: Xiyun Sun; Wenjian Zhang; Xianjun Meng; Sajad Shokri

DOI: https://doi.org/10.3389/fnut.2025.1604863

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Chromatography Conditions Development by Design of Experiments for the Chemotype Differentiation of Four Bauhinia Species.

Aquino, Amanda J; Pereira-Filho, Edenir R; Oliveira, Regina V et al. · 2022

Full title: Chromatography Conditions Development by Design of Experiments for the Chemotype Differentiation of Four Bauhinia Species.

Authors: Aquino, Amanda J; Pereira-Filho, Edenir R; Oliveira, Regina V; Cass, Quezia B

DOI: https://doi.org/10.3389/fchem.2022.800729

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Characterization of saltern based Streptomyces sp. and statistical media optimization for its improved antibacterial activity.

Rajeswari, Pandiyan; Jose, Polpass Arul; Amiya, Richa et al. · 2014

Full title: Characterization of saltern based Streptomyces sp. and statistical media optimization for its improved antibacterial activity.

Authors: Rajeswari, Pandiyan; Jose, Polpass Arul; Amiya, Richa; Jebakumar, Solomon Robinson David

DOI: https://doi.org/10.3389/fmicb.2014.00753

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3D culture of neural progenitor cells in gelatin norbornene (GelNB) hydrogels: mechanical tuning and hypoxia characterization.

Dienemann, Sandra; Wohlenberg, Ole Jacob; Gerstenberger, Jan Georg et al. · 2025

Full title: 3D culture of neural progenitor cells in gelatin norbornene (GelNB) hydrogels: mechanical tuning and hypoxia characterization.

Authors: Dienemann, Sandra; Wohlenberg, Ole Jacob; Gerstenberger, Jan Georg; Lavrentieva, Antonina; Pepelanova, Iliyana

DOI: https://doi.org/10.3389/fbioe.2025.1579580

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Exploring the Potential of Lactic Acid Fermentation for the Recovery of Exhausted Vanilla Beans.

Hadj Saadoun, Jasmine; Levante, Alessia; Ferrillo, Antonio et al. · 2022

Full title: Exploring the Potential of Lactic Acid Fermentation for the Recovery of Exhausted Vanilla Beans.

Authors: Hadj Saadoun, Jasmine; Levante, Alessia; Ferrillo, Antonio; Trapani, Francesca; Bernini, Valentina; Galaverna, Gianni; Neviani, Erasmo; Lazzi, Camilla

DOI: https://doi.org/10.3389/fnut.2022.858716

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Comprehensive Exploration of the Growth and Lipid Synthesis Phases of T. oleaginosus Cultures Implementing Design of Experiments and Response Surface Methodology.

Parisis, Vasileios; Tsave, Olga; Papanikolaou, Christina et al. · 2023

Full title: Comprehensive Exploration of the Growth and Lipid Synthesis Phases of T. oleaginosus Cultures Implementing Design of Experiments and Response Surface Methodology.

Authors: Parisis, Vasileios; Tsave, Olga; Papanikolaou, Christina; Pantazopoulou, Erasmia; Chatzidoukas, Christos

DOI: https://doi.org/10.3390/bioengineering10121359

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New Features on the Environmental Regulation of Metabolism Revealed by Modeling the Cellular Proteomic Adaptations Induced by Light, Carbon, and Inorganic Nitrogen in Chlamydomonas reinhardtii.

Gérin, Stéphanie; Leprince, Pierre; Sluse, Francis E et al. · 2016

Authors: Gérin, Stéphanie; Leprince, Pierre; Sluse, Francis E; Franck, Fabrice; Mathy, Grégory

DOI: https://doi.org/10.3389/fpls.2016.01158

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Investigation of Cellular Interactions of Lipid-Structured Nanoparticles With Oral Mucosal Epithelial Cells.

Jeitler, R; Glader, C; Tetyczka, C et al. · 2022

Full title: Investigation of Cellular Interactions of Lipid-Structured Nanoparticles With Oral Mucosal Epithelial Cells.

Authors: Jeitler, R; Glader, C; Tetyczka, C; Zeiringer, S; Absenger-Novak, M; Selmani, A; Fröhlich, E; Roblegg, E

DOI: https://doi.org/10.3389/fmolb.2022.917921

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Modeling and Optimizing Culture Medium Mineral Composition for in vitro Propagation of Actinidia arguta.

Hameg, Radhia; Arteta, Tomás A; Landin, Mariana et al. · 2020

Full title: Modeling and Optimizing Culture Medium Mineral Composition for in vitro Propagation of Actinidia arguta.

Authors: Hameg, Radhia; Arteta, Tomás A; Landin, Mariana; Gallego, Pedro P; Barreal, M Esther

DOI: https://doi.org/10.3389/fpls.2020.554905

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Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties.

Tanase, Corneliu; Mocan, Andrei; Coșarcă, Sanda et al. · 2019

Full title: Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties.

Authors: Tanase, Corneliu; Mocan, Andrei; Coșarcă, Sanda; Gavan, Alexandru; Nicolescu, Alexandru; Gheldiu, Ana-Maria; Vodnar, Dan C; Muntean, Daniela-Lucia; Crișan, Ovidiu

DOI: https://doi.org/10.3390/antiox8090417

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Combining DOE With Neurofuzzy Logic for Healthy Mineral Nutrition of Pistachio Rootstocks in vitro Culture.

Nezami-Alanagh, Esmaeil; Garoosi, Ghasem-Ali; Landín, Mariana et al. · 2018

Full title: Combining DOE With Neurofuzzy Logic for Healthy Mineral Nutrition of Pistachio Rootstocks in vitro Culture.

Authors: Nezami-Alanagh, Esmaeil; Garoosi, Ghasem-Ali; Landín, Mariana; Gallego, Pedro Pablo

DOI: https://doi.org/10.3389/fpls.2018.01474

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Exploiting the Potential of Bioactive Molecules Extracted by Ultrasounds from Avocado Peels—Food and Nutraceutical Applications

Beatriz Rodríguez-Martínez; P. Ferreira-Santos; B. Gullón et al. · 2021

Full title: Exploiting the Potential of Bioactive Molecules Extracted by Ultrasounds from Avocado Peels—Food and Nutraceutical Applications

Authors: Beatriz Rodríguez-Martínez; P. Ferreira-Santos; B. Gullón; J. Teixeira; C. Botelho; R. Yáñez

DOI: https://doi.org/10.3390/antiox10091475

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An Integrated Downstream Process Development Strategy along QbD Principles.

Meitz, Andrea; Sagmeister, Patrick; Langemann, Timo et al. · 2014

Full title: An Integrated Downstream Process Development Strategy along QbD Principles.

Authors: Meitz, Andrea; Sagmeister, Patrick; Langemann, Timo; Herwig, Christoph

DOI: https://doi.org/10.3390/bioengineering1040213

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Optimization of High-Temperature CO2 Capture by Lithium Orthosilicate-Based Sorbents Using Response Surface Methodology

Eleonora Stefanelli; Flavio Francalanci; S. Vitolo et al. · 2024

Full title: Optimization of High-Temperature CO2 Capture by Lithium Orthosilicate-Based Sorbents Using Response Surface Methodology

Authors: Eleonora Stefanelli; Flavio Francalanci; S. Vitolo; Monica Puccini

DOI: https://doi.org/10.3390/atmos15080908

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Effect of Zinc-Calcium on Xylose Consumption by Mucor circinelloides (MN128960): Xylitol and Ethanol Yield Optimization

Hector M. Fonseca-Peralta; Karen V. Pineda-Hidalgo; C. Castro-Martínez et al. · 2022

Full title: Effect of Zinc-Calcium on Xylose Consumption by Mucor circinelloides (MN128960): Xylitol and Ethanol Yield Optimization

Authors: Hector M. Fonseca-Peralta; Karen V. Pineda-Hidalgo; C. Castro-Martínez; I. Contreras-Andrade

DOI: https://doi.org/10.3390/en15030906

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Seed Train Optimization in Microcarrier-Based Cell Culture Post In Situ Cell Detachment through Scale-Down Hybrid Modeling.

Ebrahimian, Atefeh; Schalk, Mona; Dürkop, Mark et al. · 2024

Full title: Seed Train Optimization in Microcarrier-Based Cell Culture Post In Situ Cell Detachment through Scale-Down Hybrid Modeling.

Authors: Ebrahimian, Atefeh; Schalk, Mona; Dürkop, Mark; Maurer, Michael; Bliem, Rudolf; Kühnel, Harald

DOI: https://doi.org/10.3390/bioengineering11030268

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Computer-Based Tools Unmask Critical Mineral Nutrient Interactions in Hoagland Solution for Healthy Kiwiberry Plant Acclimatization.

Maleki, Sara; Maleki Zanjani, Bahram; Kohnehrouz, Bahram Baghban et al. · 2021

Full title: Computer-Based Tools Unmask Critical Mineral Nutrient Interactions in Hoagland Solution for Healthy Kiwiberry Plant Acclimatization.

Authors: Maleki, Sara; Maleki Zanjani, Bahram; Kohnehrouz, Bahram Baghban; Landin, Mariana; Gallego, Pedro Pablo

DOI: https://doi.org/10.3389/fpls.2021.723992

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Lifecycle DoE-The Companion for a Holistic Development Process.

Kunzelmann, Marco; Wittmann, Anja; Presser, Beate et al. · 2024

Full title: Lifecycle DoE-The Companion for a Holistic Development Process.

Authors: Kunzelmann, Marco; Wittmann, Anja; Presser, Beate; Brosig, Philipp; Marhoffer, Pia Kristin; Haider, Marlene Antje; Martin, Julia; Berger, Martina; Wucherpfennig, Thomas

DOI: https://doi.org/10.3390/bioengineering11111089

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Sustainable Endoglucanase Production from Lignocellulosic Waste Through Fungal Co-Culture Technology: A Step Towards Circular Economy.

Ali, Imran; Butt, Hira; Abdullah, Roheena et al. · 2026

Full title: Sustainable Endoglucanase Production from Lignocellulosic Waste Through Fungal Co-Culture Technology: A Step Towards Circular Economy.

Authors: Ali, Imran; Butt, Hira; Abdullah, Roheena; Kaleem, Afshan; Aftab, Mahwish; Iqtedar, Mehwish; Iqbal, Irfana; Chen, Xiaoming

DOI: https://doi.org/10.3390/biology15050399

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Holistic Design of Experiments Using an Integrated Process Model.

Oberleitner, Thomas; Zahel, Thomas; Pretzner, Barbara et al. · 2022

Full title: Holistic Design of Experiments Using an Integrated Process Model.

Authors: Oberleitner, Thomas; Zahel, Thomas; Pretzner, Barbara; Herwig, Christoph

DOI: https://doi.org/10.3390/bioengineering9110643

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Finite Element Analysis of a Rib Cage Model: Influence of Four Variables on Fatigue Life during Simulated Manual CPR.

Jeon, Jong Hyeok; Sul, Jae Ho; Ko, Dae Hwan et al. · 2024

Full title: Finite Element Analysis of a Rib Cage Model: Influence of Four Variables on Fatigue Life during Simulated Manual CPR.

Authors: Jeon, Jong Hyeok; Sul, Jae Ho; Ko, Dae Hwan; Seo, Myoung Jae; Kim, Sung Min; Lim, Hong Seok

DOI: https://doi.org/10.3390/bioengineering11050491

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Defining a Simplified Process in Yeast for Production of Enveloped VLP Dengue Vaccine.

de Sá Magalhães, Salomé; Morris, Stephen A; Kusumawardani, Shinta et al. · 2025

Full title: Defining a Simplified Process in Yeast for Production of Enveloped VLP Dengue Vaccine.

Authors: de Sá Magalhães, Salomé; Morris, Stephen A; Kusumawardani, Shinta; Wijayadikusumah, Acep Riza; Nurainy, Neni; Keshavarz-Moore, Eli

DOI: https://doi.org/10.3390/bioengineering12090956

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The Goldilocks Approach: A Review of Employing Design of Experiments in Prokaryotic Recombinant Protein Production.

Uhoraningoga, Albert; Kinsella, Gemma K; Henehan, Gary T et al. · 2018

Full title: The Goldilocks Approach: A Review of Employing Design of Experiments in Prokaryotic Recombinant Protein Production.

Authors: Uhoraningoga, Albert; Kinsella, Gemma K; Henehan, Gary T; Ryan, Barry J

DOI: https://doi.org/10.3390/bioengineering5040089

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A Design of Experiments Approach for Enhancing Room Temperature Stability of a Lyophilised and Paper-Based Bacterial Cell-Free System.

Shivakumar, Tejasvi; Clark, Joshua; Goode, Alice et al. · 2025

Full title: A Design of Experiments Approach for Enhancing Room Temperature Stability of a Lyophilised and Paper-Based Bacterial Cell-Free System.

Authors: Shivakumar, Tejasvi; Clark, Joshua; Goode, Alice; Anyanwu, Valentine E; Williams, Philip M

DOI: https://doi.org/10.3390/bioengineering12030223

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Maximization of the Minicircle DNA Vaccine Production Expressing SARS-CoV-2 RBD.

Ventura, Cathy; Eusébio, Dalinda; Gonçalves, Ana M et al. · 2022

Full title: Maximization of the Minicircle DNA Vaccine Production Expressing SARS-CoV-2 RBD.

Authors: Ventura, Cathy; Eusébio, Dalinda; Gonçalves, Ana M; Barroca-Ferreira, Jorge; Costa, Diana; Cui, Zhengrong; Passarinha, Luís A; Sousa, Ângela

DOI: https://doi.org/10.3390/biomedicines10050990

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The Statistical Optimisation of Recombinant β-glucosidase Production through a Two-Stage, Multi-Model, Design of Experiments Approach.

Uhoraningoga, Albert; Kinsella, Gemma K; Frias, Jesus M et al. · 2019

Full title: The Statistical Optimisation of Recombinant β-glucosidase Production through a Two-Stage, Multi-Model, Design of Experiments Approach.

Authors: Uhoraningoga, Albert; Kinsella, Gemma K; Frias, Jesus M; Henehan, Gary T; Ryan, Barry J

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Bayesian Optimization Based on K-Optimality.

Yan, Liang; Duan, Xiaojun; Liu, Bowen et al. · 2018

Full title: Bayesian Optimization Based on K-Optimality.

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Design of Experiments for Optimizing Ultrasound-Assisted Extraction of Bioactive Compounds from Plant-Based Sources.

Anaya-Esparza, Luis Miguel; Aurora-Vigo, Edward F; Villagrán, Zuamí et al. · 2023

Full title: Design of Experiments for Optimizing Ultrasound-Assisted Extraction of Bioactive Compounds from Plant-Based Sources.

DOI: https://doi.org/10.3390/molecules28237752

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Application of Experimental Design Methodologies in the Enantioseparation of Pharmaceuticals by Capillary Electrophoresis: A Review.

Hancu, Gabriel; Orlandini, Serena; Papp, Lajos Attila et al. · 2021

Full title: Application of Experimental Design Methodologies in the Enantioseparation of Pharmaceuticals by Capillary Electrophoresis: A Review.

Authors: Hancu, Gabriel; Orlandini, Serena; Papp, Lajos Attila; Modroiu, Adriana; Gotti, Roberto; Furlanetto, Sandra

DOI: https://doi.org/10.3390/molecules26154681

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Green Method Comparison and Optimization of Anthocyanin Recovery from "Sangiovese" Grape Pomace: A Critical Evaluation of the Design of Experiments Approach.

Lianza, Mariacaterina; Antognoni, Fabiana · 2024

Full title: Green Method Comparison and Optimization of Anthocyanin Recovery from "Sangiovese" Grape Pomace: A Critical Evaluation of the Design of Experiments Approach.

Authors: Lianza, Mariacaterina; Antognoni, Fabiana

DOI: https://doi.org/10.3390/molecules29112679

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Important Aspects of the Design of Experiments and Data Treatment in the Analytical Quality by Design Framework for Chromatographic Method Development.

Passerine, Bianca F G; Breitkreitz, Márcia C · 2024

Full title: Important Aspects of the Design of Experiments and Data Treatment in the Analytical Quality by Design Framework for Chromatographic Method Development.

Authors: Passerine, Bianca F G; Breitkreitz, Márcia C

DOI: https://doi.org/10.3390/molecules29246057

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Influence of the Binder Jetting Process Parameters and Binder Liquid Composition on the Relevant Attributes of 3D-Printed Tablets.

Kreft, Klemen; Lavrič, Zoran; Stanić, Tijana et al. · 2022

Full title: Influence of the Binder Jetting Process Parameters and Binder Liquid Composition on the Relevant Attributes of 3D-Printed Tablets.

Authors: Kreft, Klemen; Lavrič, Zoran; Stanić, Tijana; Perhavec, Petra; Dreu, Rok

DOI: https://doi.org/10.3390/pharmaceutics14081568

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Design of Experiments to Achieve an Efficient Chitosan-Based DNA Vaccine Delivery System.

Rodolfo, Carlos; Eusébio, Dalinda; Ventura, Cathy et al. · 2021

Full title: Design of Experiments to Achieve an Efficient Chitosan-Based DNA Vaccine Delivery System.

Authors: Rodolfo, Carlos; Eusébio, Dalinda; Ventura, Cathy; Nunes, Renato; Florindo, Helena F; Costa, Diana; Sousa, Ângela

DOI: https://doi.org/10.3390/pharmaceutics13091369

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QbD-Based Formulation Development of Amiodarone Hydrochloride Tablet.

Jeon, Chae-Won; Yoon, Ju-Hyun; Kim, Joo-Eun · 2026

Full title: QbD-Based Formulation Development of Amiodarone Hydrochloride Tablet.

Authors: Jeon, Chae-Won; Yoon, Ju-Hyun; Kim, Joo-Eun

DOI: https://doi.org/10.3390/pharmaceutics18020264

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Lipid-Based Nanocarriers for Ophthalmic Administration: Towards Experimental Design Implementation.

González-Fernández, Felipe M; Bianchera, Annalisa; Gasco, Paolo et al. · 2021

Full title: Lipid-Based Nanocarriers for Ophthalmic Administration: Towards Experimental Design Implementation.

Authors: González-Fernández, Felipe M; Bianchera, Annalisa; Gasco, Paolo; Nicoli, Sara; Pescina, Silvia

DOI: https://doi.org/10.3390/pharmaceutics13040447

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Lipase-Assisted Synthesis of Alkyl Stearates: Optimization by Taguchi Design of Experiments and Application as Defoamers.

Olvera-Ureña, Enoch; Lopez-Tellez, Jorge; Vizueto, M Monserrat et al. · 2023

Full title: Lipase-Assisted Synthesis of Alkyl Stearates: Optimization by Taguchi Design of Experiments and Application as Defoamers.

Authors: Olvera-Ureña, Enoch; Lopez-Tellez, Jorge; Vizueto, M Monserrat; Hidalgo-Ledezma, J Guadalupe; Martinez-Quiroz, Baltazar; Rodriguez, Jose A

DOI: https://doi.org/10.3390/molecules29010195

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Process Optimization and Upscaling of Spray-Dried Drug-Amino acid Co-Amorphous Formulations.

Kasten, Georgia; Duarte, Íris; Paisana, Maria et al. · 2019

Full title: Process Optimization and Upscaling of Spray-Dried Drug-Amino acid Co-Amorphous Formulations.

Authors: Kasten, Georgia; Duarte, Íris; Paisana, Maria; Löbmann, Korbinian; Rades, Thomas; Grohganz, Holger

DOI: https://doi.org/10.3390/pharmaceutics11010024

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Design and Manufacturing of Antibacterial Electrospun Polysulfone Membranes Functionalized by Ag Nanocoating via Magnetron Sputtering.

Fiaschini, Noemi; Giuliani, Chiara; Vitali, Roberta et al. · 2022

Full title: Design and Manufacturing of Antibacterial Electrospun Polysulfone Membranes Functionalized by Ag Nanocoating via Magnetron Sputtering.

Authors: Fiaschini, Noemi; Giuliani, Chiara; Vitali, Roberta; Tammaro, Loredana; Valerini, Daniele; Rinaldi, Antonio

DOI: https://doi.org/10.3390/nano12223962

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Sustainable and Biomimetic Methodology for Extraction of High-Value-Added Compounds in Almond Hulls.

Cremasco, Gabriela; Sutton, Adam T; Funari, Cristiano S et al. · 2024

Full title: Sustainable and Biomimetic Methodology for Extraction of High-Value-Added Compounds in Almond Hulls.

Authors: Cremasco, Gabriela; Sutton, Adam T; Funari, Cristiano S; Arrua, Dario R; Dussan, Kelly J; Hilder, Emily F; Bolzani, Vanderlan S; Rinaldo, Daniel

DOI: https://doi.org/10.3390/molecules29133034

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Model-Based Product Temperature and Endpoint Determination in Primary Drying of Lyophilization Processes.

Juckers, Alex; Knerr, Petra; Harms, Frank et al. · 2022

Full title: Model-Based Product Temperature and Endpoint Determination in Primary Drying of Lyophilization Processes.

Authors: Juckers, Alex; Knerr, Petra; Harms, Frank; Strube, Jochen

DOI: https://doi.org/10.3390/pharmaceutics14040809

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Optimization of Solid Lipid Nanoparticle Formulation Using Design of Experiments, PART I: Strategic Tool for the Determination of Critical Parameters Regarding Formulation and Process.

Cassayre, Margot; Teles de Souza, Dany; Claeys-Bruno, Magalie et al. · 2025

Full title: Optimization of Solid Lipid Nanoparticle Formulation Using Design of Experiments, PART I: Strategic Tool for the Determination of Critical Parameters Regarding Formulation and Process.

Authors: Cassayre, Margot; Teles de Souza, Dany; Claeys-Bruno, Magalie; Altié, Alexandre; Piccerelle, Philippe; Sauzet, Christophe

DOI: https://doi.org/10.3390/nano15131034

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Quality by Design (QbD)-Driven Development and Optimization of Tacrolimus-Loaded Microemulsion for the Treatment of Skin Inflammation.

Srishti, Sanjida Ahmed; Pinky, Paromita Paul; Taylor, Ryan et al. · 2024

Full title: Quality by Design (QbD)-Driven Development and Optimization of Tacrolimus-Loaded Microemulsion for the Treatment of Skin Inflammation.

Authors: Srishti, Sanjida Ahmed; Pinky, Paromita Paul; Taylor, Ryan; Guess, Jacob; Karlik, Natasha; Janjic, Jelena M

DOI: https://doi.org/10.3390/pharmaceutics16121487

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The Application of the Design of Experiments and Artificial Neural Networks in the Development of a Fast and Straightforward HPLC-UV Method for Fluconazole Determination in Hemato-Oncologic Pediatric Patients and Its Adaptation to Therapeutic Drug Monitoring.

Adamiszak, Arkadiusz; Czyrski, Andrzej; Sznek, Bartosz et al. · 2024

Authors: Adamiszak, Arkadiusz; Czyrski, Andrzej; Sznek, Bartosz; Grześkowiak, Edmund; Bienert, Agnieszka

DOI: https://doi.org/10.3390/ph17121679

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Quality by Design Micro-Engineering Optimisation of NSAID-Loaded Electrospun Fibrous Patches.

Nazari, Kazem; Mehta, Prina; Arshad, Muhammad Sohail et al. · 2019

Full title: Quality by Design Micro-Engineering Optimisation of NSAID-Loaded Electrospun Fibrous Patches.

Authors: Nazari, Kazem; Mehta, Prina; Arshad, Muhammad Sohail; Ahmed, Shahabuddin; Andriotis, Eleftherios G; Singh, Neenu; Qutachi, Omar; Chang, Ming-Wei; Fatouros, Dimitrios G; Ahmad, Zeeshan

DOI: https://doi.org/10.3390/pharmaceutics12010002

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Microfluidics-Assisted Formulation of Polymeric Oxytocin Nanoparticles for Targeted Brain Delivery.

Adediran, Emmanuel; Vijayanand, Sharon; Kale, Akanksha et al. · 2025

Full title: Microfluidics-Assisted Formulation of Polymeric Oxytocin Nanoparticles for Targeted Brain Delivery.

Authors: Adediran, Emmanuel; Vijayanand, Sharon; Kale, Akanksha; Gulani, Mahek; Wong, Jennifer C; Escayg, Andrew; Murnane, Kevin S; D'Souza, Martin J

DOI: https://doi.org/10.3390/pharmaceutics17040452

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Aerosolizable Lipid Nanoparticles for Pulmonary Delivery of mRNA through Design of Experiments.

Zhang, Hairui; Leal, Jasmim; Soto, Melissa R et al. · 2020

Full title: Aerosolizable Lipid Nanoparticles for Pulmonary Delivery of mRNA through Design of Experiments.

Authors: Zhang, Hairui; Leal, Jasmim; Soto, Melissa R; Smyth, Hugh D C; Ghosh, Debadyuti

DOI: https://doi.org/10.3390/pharmaceutics12111042

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Box–Behnken Design of Experiments of Polycaprolactone Nanoparticles Loaded with Irinotecan Hydrochloride

Mahmoud, Basant Salah; McConville, Christopher · 2023

Full title: Box–Behnken Design of Experiments of Polycaprolactone Nanoparticles Loaded with Irinotecan Hydrochloride

Authors: Mahmoud, Basant Salah; McConville, Christopher

DOI: https://doi.org/10.3390/pharmaceutics15041271

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Optimization of Enterovirus-like Particle Production and Purification Using Design of Experiments.

Kuijpers, Louis; van den Braak, Wouter J P; Freydoonian, Abbas et al. · 2025

Full title: Optimization of Enterovirus-like Particle Production and Purification Using Design of Experiments.

Authors: Kuijpers, Louis; van den Braak, Wouter J P; Freydoonian, Abbas; Dekker, Nynke H; van der Pol, Leo A

DOI: https://doi.org/10.3390/pathogens14020118

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Application of Design of Experiments in the Development of Self-Microemulsifying Drug Delivery Systems.

Hsieh, Chien-Ming; Yang, Ting-Lun; Putri, Athika Darumas et al. · 2023

Full title: Application of Design of Experiments in the Development of Self-Microemulsifying Drug Delivery Systems.

Authors: Hsieh, Chien-Ming; Yang, Ting-Lun; Putri, Athika Darumas; Chen, Chin-Tin

DOI: https://doi.org/10.3390/ph16020283

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Determination of Response Factors for Analytes Detected during Migration Studies, Strategy and Internal Standard Selection for Risk Minimization.

Kritikos, Nikolaos; Bletsou, Anna; Konstantinou, Christina et al. · 2023

Full title: Determination of Response Factors for Analytes Detected during Migration Studies, Strategy and Internal Standard Selection for Risk Minimization.

Authors: Kritikos, Nikolaos; Bletsou, Anna; Konstantinou, Christina; Neofotistos, Antonios-Dionysios; Kousoulos, Constantinos; Dotsikas, Yannis

DOI: https://doi.org/10.3390/molecules28155772

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Quality by Design Methodology Applied to Process Optimization and Scale up of Curcumin Nanoemulsions Produced by Catastrophic Phase Inversion.

Adena, Sandeep Kumar Reddy; Herneisey, Michele; Pierce, Eric et al. · 2021

Full title: Quality by Design Methodology Applied to Process Optimization and Scale up of Curcumin Nanoemulsions Produced by Catastrophic Phase Inversion.

Authors: Adena, Sandeep Kumar Reddy; Herneisey, Michele; Pierce, Eric; Hartmeier, Paul R; Adlakha, Suneera; Hosfeld, Marco A I; Drennen, James K; Janjic, Jelena M

DOI: https://doi.org/10.3390/pharmaceutics13060880

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Valorization of Turnip Greens (Brassica rapa subsp. sylvestris) Wastes: Investigation on the Sustainable Recovery of Bioactive Extracts with Antioxidant and Antibiofilm Properties.

Maurelli, Anna Maria; Coniglio, Davide; Milano, Francesco et al. · 2026

Full title: Valorization of Turnip Greens (Brassica rapa subsp. sylvestris) Wastes: Investigation on the Sustainable Recovery of Bioactive Extracts with Antioxidant and Antibiofilm Properties.

DOI: https://doi.org/10.3390/molecules31020388

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QbD-Based Development and Evaluation of Pazopanib Hydrochloride Extrudates Prepared by Hot-Melt Extrusion Technique: In Vitro and In Vivo Evaluation.

Gupta, Amit; Dahima, Rashmi; Panda, Sunil K et al. · 2024

Full title: QbD-Based Development and Evaluation of Pazopanib Hydrochloride Extrudates Prepared by Hot-Melt Extrusion Technique: In Vitro and In Vivo Evaluation.

Authors: Gupta, Amit; Dahima, Rashmi; Panda, Sunil K; Gupta, Annie; Singh, Gaurav Deep; Wani, Tanveer A; Hussain, Afzal; Rathore, Devashish

DOI: https://doi.org/10.3390/pharmaceutics16060764

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Optimized Green Extraction of Polyphenols from Cassia javanica L. Petals for Their Application in Sunflower Oil: Anticancer and Antioxidant Properties

M. I. Younis; Xiaofeng Ren; A. K. Alzubaidi et al. · 2022

Full title: Optimized Green Extraction of Polyphenols from Cassia javanica L. Petals for Their Application in Sunflower Oil: Anticancer and Antioxidant Properties

Authors: M. I. Younis; Xiaofeng Ren; A. K. Alzubaidi; K. Mahmoud; A. Altemimi; F. Cacciola; Husnain Raza; Anubhav Pratap‐Singh; T. Abedelmaksoud

DOI: https://doi.org/10.3390/molecules27144329

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Can We Simplify Liposome Manufacturing Using a Complex DoE Approach?

Lindsay, Sarah; Tumolva, Olympia; Khamiakova, Tatsiana et al. · 2024

Full title: Can We Simplify Liposome Manufacturing Using a Complex DoE Approach?

Authors: Lindsay, Sarah; Tumolva, Olympia; Khamiakova, Tatsiana; Coppenolle, Hans; Kovarik, Martin; Shah, Sanket; Holm, René; Perrie, Yvonne

DOI: https://doi.org/10.3390/pharmaceutics16091159

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Development of Biopredictive Dissolution Method for Extended-Release Desvenlafaxine Tablets.

Carapeto, Gustavo Vaiano; Duque, Marcelo Dutra; Issa, Michele Georges et al. · 2023

Full title: Development of Biopredictive Dissolution Method for Extended-Release Desvenlafaxine Tablets.

Authors: Carapeto, Gustavo Vaiano; Duque, Marcelo Dutra; Issa, Michele Georges; Ferraz, Humberto Gomes

DOI: https://doi.org/10.3390/pharmaceutics15051544

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Rheology of Complex Topical Formulations: An Analytical Quality by Design Approach to Method Optimization and Validation.

Chiarentin, Lucas; Cardoso, Catarina; Miranda, Margarida et al. · 2023

Full title: Rheology of Complex Topical Formulations: An Analytical Quality by Design Approach to Method Optimization and Validation.

Authors: Chiarentin, Lucas; Cardoso, Catarina; Miranda, Margarida; Vitorino, Carla

DOI: https://doi.org/10.3390/pharmaceutics15071810

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Process Development for the Continuous Manufacturing of Carbamazepine-Nicotinamide Co-Crystals Utilizing Hot-Melt Extrusion Technology.

Huang, Lianghao; Ni, Wen; Jia, Yaru et al. · 2025

Full title: Process Development for the Continuous Manufacturing of Carbamazepine-Nicotinamide Co-Crystals Utilizing Hot-Melt Extrusion Technology.

Authors: Huang, Lianghao; Ni, Wen; Jia, Yaru; Zhu, Minqing; Yang, Tiantian; Yu, Mingchao; Zhang, Jiaxiang

DOI: https://doi.org/10.3390/pharmaceutics17050568

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Development of a 3D Printing Liquid Crystal Display (LCD)-Assisted Micromolding Methodology for Custom Fabrication of Polymeric Microneedles Using Experimental Design.

Antonara, Lefkothea; Rekkas, Dimitrios M; Pippa, Natassa et al. · 2025

Full title: Development of a 3D Printing Liquid Crystal Display (LCD)-Assisted Micromolding Methodology for Custom Fabrication of Polymeric Microneedles Using Experimental Design.

Authors: Antonara, Lefkothea; Rekkas, Dimitrios M; Pippa, Natassa; Dallas, Paraskevas P

DOI: https://doi.org/10.3390/pharmaceutics17121571

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Intensification of Polyphenols Extraction from Eryngium creticum Leaves Using Ired-Irrad® and Evaluation of Antibiofilm and Antibacterial Activities

M. Hammoud; A. Chokr; H. Rajha et al. · 2022

Full title: Intensification of Polyphenols Extraction from Eryngium creticum Leaves Using Ired-Irrad® and Evaluation of Antibiofilm and Antibacterial Activities

Authors: M. Hammoud; A. Chokr; H. Rajha; C. Safi; Martijn van Walsem; L. A. Broek; Espérance Debs; R. Maroun; N. Louka; H. Rammal

DOI: https://doi.org/10.3390/plants11192458

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Artificial neural networks in evaluation and optimization of modified release solid dosage forms.

Ibrić, Svetlana; Djuriš, Jelena; Parojčić, Jelena et al. · 2012

Full title: Artificial neural networks in evaluation and optimization of modified release solid dosage forms.

Authors: Ibrić, Svetlana; Djuriš, Jelena; Parojčić, Jelena; Djurić, Zorica

DOI: https://doi.org/10.3390/pharmaceutics4040531

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Optimize, Modulate, and Scale-up Resveratrol and Resveratrol Dimers Bioproduction in Vitis labrusca L. Cell Suspension from Flasks to 20 L Bioreactor

C. Lambert; J. Lemaire; Hélène Auger et al. · 2019

Full title: Optimize, Modulate, and Scale-up Resveratrol and Resveratrol Dimers Bioproduction in Vitis labrusca L. Cell Suspension from Flasks to 20 L Bioreactor

Authors: C. Lambert; J. Lemaire; Hélène Auger; Arnaud Guilleret; R. Reynaud; C. Clément; E. Courot; B. Taidi

DOI: https://doi.org/10.3390/plants8120567

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Parameter Screening of PVDF/PVP Multi-Channel Capillary Membranes.

Back, Jan O; Brandstätter, Rupert; Spruck, Martin et al. · 2019

Full title: Parameter Screening of PVDF/PVP Multi-Channel Capillary Membranes.

Authors: Back, Jan O; Brandstätter, Rupert; Spruck, Martin; Koch, Marc; Penner, Simon; Rupprich, Marco

DOI: https://doi.org/10.3390/polym11030463

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A Design of Experiments Approach to Identify Critical Processing Parameters for Manufacture of an Autologous Platelet Gel for Diabetic Foot Ulcer.

Olszewska, Aleksandra; Egorova, Olga; Gaggia, Gabriella et al. · 2025

Full title: A Design of Experiments Approach to Identify Critical Processing Parameters for Manufacture of an Autologous Platelet Gel for Diabetic Foot Ulcer.

Authors: Olszewska, Aleksandra; Egorova, Olga; Gaggia, Gabriella; Mylona, Kalliopi; Pitchford, Simon; Rickard, James; Forbes, Ben

DOI: https://doi.org/10.3390/pharmaceutics17111482

Paper

Aspects and Implementation of Pharmaceutical Quality by Design from Conceptual Frameworks to Industrial Applications.

Yang, Shiwei; Hu, Xingming; Zhu, Jinmiao et al. · 2025

Full title: Aspects and Implementation of Pharmaceutical Quality by Design from Conceptual Frameworks to Industrial Applications.

Authors: Yang, Shiwei; Hu, Xingming; Zhu, Jinmiao; Zheng, Bin; Bi, Wenjie; Wang, Xiaohong; Wu, Jialing; Mi, Zimeng; Wu, Yifei

DOI: https://doi.org/10.3390/pharmaceutics17050623

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Experimental and Modeling-Based Approaches for Mechanistic Understanding of Pan Coating Process-A Detailed Review.

Aminahmadi, Behrad; Vaes, Elise; Willemse, Filip et al. · 2025

Full title: Experimental and Modeling-Based Approaches for Mechanistic Understanding of Pan Coating Process-A Detailed Review.

Authors: Aminahmadi, Behrad; Vaes, Elise; Willemse, Filip; Braile, Domenica; Gomez, Luz Naranjo; Andersen, Sune Klint; Beer, Thomas De; Kumar, Ashish

DOI: https://doi.org/10.3390/pharmaceutics18010019

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Quality by Design and In Silico Approach in SNEDDS Development: A Comprehensive Formulation Framework.

Priani, Sani Ega; Fakih, Taufik Muhammad; Wilar, Gofarana et al. · 2025

Full title: Quality by Design and In Silico Approach in SNEDDS Development: A Comprehensive Formulation Framework.

Authors: Priani, Sani Ega; Fakih, Taufik Muhammad; Wilar, Gofarana; Chaerunisaa, Anis Yohana; Sopyan, Iyan

DOI: https://doi.org/10.3390/pharmaceutics17060701

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Optimization of a Green Ultrasound-Assisted Extraction of Different Polyphenols from Pistacia lentiscus L. Leaves Using a Response Surface Methodology.

Detti, Cassandra; Dos Santos Nascimento, Luana Beatriz; Brunetti, Cecilia et al. · 2020

Full title: Optimization of a Green Ultrasound-Assisted Extraction of Different Polyphenols from Pistacia lentiscus L. Leaves Using a Response Surface Methodology.

Authors: Detti, Cassandra; Dos Santos Nascimento, Luana Beatriz; Brunetti, Cecilia; Ferrini, Francesco; Gori, Antonella

DOI: https://doi.org/10.3390/plants9111482

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Artificial Neural Networks Elucidated the Essential Role of Mineral Nutrients versus Vitamins and Plant Growth Regulators in Achieving Healthy Micropropagated Plants.

Arteta, Tomás A; Hameg, Radhia; Landin, Mariana et al. · 2022

Full title: Artificial Neural Networks Elucidated the Essential Role of Mineral Nutrients versus Vitamins and Plant Growth Regulators in Achieving Healthy Micropropagated Plants.

Authors: Arteta, Tomás A; Hameg, Radhia; Landin, Mariana; Gallego, Pedro P; Barreal, M Esther

DOI: https://doi.org/10.3390/plants11101284

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Design of Experiments-Based Optimization of Flavonoids Extraction from Daphne genkwa Flower Buds and Flavonoids Contents at Different Blooming Stages.

Kim, Min-Kyoung; Park, Geonha; Ji, Yura et al. · 2022

Full title: Design of Experiments-Based Optimization of Flavonoids Extraction from Daphne genkwa Flower Buds and Flavonoids Contents at Different Blooming Stages.

Authors: Kim, Min-Kyoung; Park, Geonha; Ji, Yura; Lee, Yun-Gyo; Choi, Minsik; Go, Seung-Hyeon; Son, Miwon; Jang, Young-Pyo

DOI: https://doi.org/10.3390/plants11070925

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Dissolution of Silk Fibroin in Mixtures of Ionic Liquids and Dimethyl Sulfoxide: On the Relative Importance of Temperature and Binary Solvent Composition.

El Seoud, Omar A; Kostag, Marc; Possidonio, Shirley et al. · 2021

Full title: Dissolution of Silk Fibroin in Mixtures of Ionic Liquids and Dimethyl Sulfoxide: On the Relative Importance of Temperature and Binary Solvent Composition.

Authors: El Seoud, Omar A; Kostag, Marc; Possidonio, Shirley; Dignani, Marcella T; Pires, Paulo A R; Lourenço, Matheus C

DOI: https://doi.org/10.3390/polym14010013

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History, Phylogeny, Biodiversity, and New Computer-Based Tools for Efficient Micropropagation and Conservation of Pistachio (Pistacia spp.) Germplasm.

Nezami, Esmaeil; Gallego, Pedro P · 2023

Full title: History, Phylogeny, Biodiversity, and New Computer-Based Tools for Efficient Micropropagation and Conservation of Pistachio (Pistacia spp.) Germplasm.

Authors: Nezami, Esmaeil; Gallego, Pedro P

DOI: https://doi.org/10.3390/plants12020323

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Experimental Design in Polymer Chemistry-A Guide towards True Optimization of a RAFT Polymerization Using Design of Experiments (DoE).

Eckert, Tilman; Klein, Florian C; Frieler, Piet et al. · 2021

Full title: Experimental Design in Polymer Chemistry-A Guide towards True Optimization of a RAFT Polymerization Using Design of Experiments (DoE).

Authors: Eckert, Tilman; Klein, Florian C; Frieler, Piet; Thunich, Oliver; Abetz, Volker

DOI: https://doi.org/10.3390/polym13183147

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Extraction, Isolation, Screening, and Preliminary Characterization of Polysaccharides with Anti–Oxidant Activities from Oudemansiella raphanipies

Junqiang Qiu; Wang Shi; Jingnan Miao et al. · 2023

Full title: Extraction, Isolation, Screening, and Preliminary Characterization of Polysaccharides with Anti–Oxidant Activities from Oudemansiella raphanipies

Authors: Junqiang Qiu; Wang Shi; Jingnan Miao; Hui Hu; Yanan Gao

DOI: https://doi.org/10.3390/polym15132917

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The Use of Response Surface Methodology to Optimize Assisted Extraction of Bioactive Compounds from Cucurbita maxima Fruit By-Products

R. B. Mansour; H. Falleh; M. Hammami et al. · 2023

Full title: The Use of Response Surface Methodology to Optimize Assisted Extraction of Bioactive Compounds from Cucurbita maxima Fruit By-Products

Authors: R. B. Mansour; H. Falleh; M. Hammami; L. Barros; S. Petropoulos; N. Tarchoun; R. Ksouri

DOI: https://doi.org/10.3390/pr11061726

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Fused-Filament Fabrication of Short Carbon Fiber-Reinforced Polyamide: Parameter Optimization for Improved Performance under Uniaxial Tensile Loading.

Belei, Carlos; Joeressen, Jana; Amancio-Filho, Sergio T · 2022

Full title: Fused-Filament Fabrication of Short Carbon Fiber-Reinforced Polyamide: Parameter Optimization for Improved Performance under Uniaxial Tensile Loading.

Authors: Belei, Carlos; Joeressen, Jana; Amancio-Filho, Sergio T

DOI: https://doi.org/10.3390/polym14071292

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A Design of Experiments (DoE) Approach to Optimize Cryogel Manufacturing for Tissue Engineering Applications.

Carvalho, Duarte Nuno; Gonçalves, Cristiana; Oliveira, Joaquim Miguel et al. · 2022

Full title: A Design of Experiments (DoE) Approach to Optimize Cryogel Manufacturing for Tissue Engineering Applications.

Authors: Carvalho, Duarte Nuno; Gonçalves, Cristiana; Oliveira, Joaquim Miguel; Williams, David S; Mearns-Spragg, Andrew; Reis, Rui L; Silva, Tiago H

DOI: https://doi.org/10.3390/polym14102026

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Modeling, the Optimization of the Composition of Emulgels with Ciclopirox Olamine, and Quality Assessment.

Mazurkeviciute, Agne; Matulyte, Inga; Ivaskiene, Marija et al. · 2024

Full title: Modeling, the Optimization of the Composition of Emulgels with Ciclopirox Olamine, and Quality Assessment.

Authors: Mazurkeviciute, Agne; Matulyte, Inga; Ivaskiene, Marija; Zilius, Modestas

DOI: https://doi.org/10.3390/polym16131816

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Optimization of Polyacrylic Acid Coating on Graphene Oxide-Functionalized Reverse-Osmosis Membrane Using UV Radiation through Response Surface Methodology.

Ashfaq, Mohammad Yousaf; Al-Ghouti, Mohammad A · 2022

Full title: Optimization of Polyacrylic Acid Coating on Graphene Oxide-Functionalized Reverse-Osmosis Membrane Using UV Radiation through Response Surface Methodology.

Authors: Ashfaq, Mohammad Yousaf; Al-Ghouti, Mohammad A

DOI: https://doi.org/10.3390/polym14183711

Paper

Analytical Enantio-Separation of Linagliptin in Linagliptin and Metformin HCl Dosage Forms by Applying Two-Level Factorial Design.

Jadhav, Sushant B; Mane, Rahul M; Narayanan, Kalyanraman L et al. · 2016

Full title: Analytical Enantio-Separation of Linagliptin in Linagliptin and Metformin HCl Dosage Forms by Applying Two-Level Factorial Design.

Authors: Jadhav, Sushant B; Mane, Rahul M; Narayanan, Kalyanraman L; Bhosale, Popatrao N

DOI: https://doi.org/10.3390/scipharm84040671

Paper

Analyzing Homogeneity of Highly Viscous Polymer Suspensions in Change Can Mixers.

Larsen, Michael Roland; Holmen Olofsson, Erik Tomas; Spangenberg, Jon · 2024

Full title: Analyzing Homogeneity of Highly Viscous Polymer Suspensions in Change Can Mixers.

Authors: Larsen, Michael Roland; Holmen Olofsson, Erik Tomas; Spangenberg, Jon

DOI: https://doi.org/10.3390/polym16182675

Paper

A Novel Approach for the Estimation of the Efficiency of Demulsification of Water-In-Crude Oil Emulsions.

Nešić, Slavko; Govedarica, Olga; Jovičić, Mirjana et al. · 2025

Full title: A Novel Approach for the Estimation of the Efficiency of Demulsification of Water-In-Crude Oil Emulsions.

Authors: Nešić, Slavko; Govedarica, Olga; Jovičić, Mirjana; Žeravica, Julijana; Stojanov, Sonja; Antić, Cvijan; Govedarica, Dragan

DOI: https://doi.org/10.3390/polym17212957

Paper

Optimization and Modeling of Citrobacter freundii AD119 Growth and 1,3-Propanediol Production Using Two-Step Statistical Experimental Design and Artificial Neural Networks

A. Drożdżyńska; J. Wawrzyniak; P. Kubiak et al. · 2023

Full title: Optimization and Modeling of Citrobacter freundii AD119 Growth and 1,3-Propanediol Production Using Two-Step Statistical Experimental Design and Artificial Neural Networks

Authors: A. Drożdżyńska; J. Wawrzyniak; P. Kubiak; Martyna Przybylak; W. Białas; K. Czaczyk

DOI: https://doi.org/10.3390/s23031266

Paper

Enhancing Process Control and Quality in Amorphous Solid Dispersions Using In-Line UV-Vis Monitoring of L* as a Real-Time Response.

Bezerra, Mariana; Almeida, Juan; de Castro, Matheus et al. · 2025

Full title: Enhancing Process Control and Quality in Amorphous Solid Dispersions Using In-Line UV-Vis Monitoring of L* as a Real-Time Response.

Authors: Bezerra, Mariana; Almeida, Juan; de Castro, Matheus; Grootveld, Martin; Schlindwein, Walkiria

DOI: https://doi.org/10.3390/pharmaceutics17020151

Paper

Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors.

Graf, Alexander; Woodhams, Angus; Nelson, Michael et al. · 2022

Full title: Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors.

Authors: Graf, Alexander; Woodhams, Angus; Nelson, Michael; Richardson, Douglas D; Short, Steven M; Brower, Mark; Hoehse, Marek

DOI: https://doi.org/10.3390/s22093397

Paper

Biogas Upgrading by Pressure Swing Adsorption with Design of Experiments

Chen, Yi-Fang; Lin, Po-Wei; Chen, Wen‐Hua et al. · 2021

Full title: Biogas Upgrading by Pressure Swing Adsorption with Design of Experiments

Authors: Chen, Yi-Fang; Lin, Po-Wei; Chen, Wen‐Hua; Yen, Fong-Yu; Yang, Hong-Sung; Chou, Cheng-Tung

DOI: https://doi.org/10.3390/pr9081325

Paper

Comparison of four functionalization methods of gold nanoparticles for enhancing the enzyme-linked immunosorbent assay (ELISA).

Ciaurriz, Paula; Fernández, Fátima; Tellechea, Edurne et al. · 2017

Full title: Comparison of four functionalization methods of gold nanoparticles for enhancing the enzyme-linked immunosorbent assay (ELISA).

Authors: Ciaurriz, Paula; Fernández, Fátima; Tellechea, Edurne; Moran, Jose F; Asensio, Aaron C

DOI: https://doi.org/10.3762/bjnano.8.27

Paper

Challenges and Opportunities in the Process Development of Chimeric Vaccines.

Chauhan, Shivani; Khasa, Yogender Pal · 2023

Full title: Challenges and Opportunities in the Process Development of Chimeric Vaccines.

Authors: Chauhan, Shivani; Khasa, Yogender Pal

DOI: https://doi.org/10.3390/vaccines11121828

Paper

Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A-F Employing Taguchi Design-of-Experiments.

von Berg, Laura; Stern, Daniel; Weisemann, Jasmin et al. · 2019

Full title: Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A-F Employing Taguchi Design-of-Experiments.

Authors: von Berg, Laura; Stern, Daniel; Weisemann, Jasmin; Rummel, Andreas; Dorner, Martin Bernhard; Dorner, Brigitte Gertrud

DOI: https://doi.org/10.3390/toxins11100588

Paper

Development of Long-Term Stability of Enveloped rVSV Viral Vector Expressing SARS-CoV-2 Antigen Using a DOE-Guided Approach.

Khan, M D Faizul Hussain; Wagner, Caroline E; Kamen, Amine A · 2024

Full title: Development of Long-Term Stability of Enveloped rVSV Viral Vector Expressing SARS-CoV-2 Antigen Using a DOE-Guided Approach.

Authors: Khan, M D Faizul Hussain; Wagner, Caroline E; Kamen, Amine A

DOI: https://doi.org/10.3390/vaccines12111240

Paper

Implementation of a Design of Experiments to Improve Periplasmic Yield of Functional ScFv Antibodies in a Phage Display Platform.

Aghdam, Marjan Abri; Tohidkia, Mohammad Reza; Ghamghami, Elham et al. · 2022

Full title: Implementation of a Design of Experiments to Improve Periplasmic Yield of Functional ScFv Antibodies in a Phage Display Platform.

Authors: Aghdam, Marjan Abri; Tohidkia, Mohammad Reza; Ghamghami, Elham; Ahmadikhah, Asadollah; Khanmahamadi, Morteza; Baradaran, Behzad; Mokhtarzadeh, Ahad

DOI: https://doi.org/10.34172/apb.2022.061

Paper

Optimization, Production, Purification and Characterization of HIV-1 GAG-Based Virus-like Particles Functionalized with SARS-CoV-2.

Boix-Besora, Arnau; Lorenzo, Elianet; Lavado-García, Jesús et al. · 2022

Full title: Optimization, Production, Purification and Characterization of HIV-1 GAG-Based Virus-like Particles Functionalized with SARS-CoV-2.

Authors: Boix-Besora, Arnau; Lorenzo, Elianet; Lavado-García, Jesús; Gòdia, Francesc; Cervera, Laura

DOI: https://doi.org/10.3390/vaccines10020250

Paper

Optimization of Phenolic Compound Extraction from Brewers’ Spent Grain Using Ultrasound Technologies Coupled with Response Surface Methodology

Rosamaria Iadecola; R. Ciccoritti; B. Ceccantoni et al. · 2022

Full title: Optimization of Phenolic Compound Extraction from Brewers’ Spent Grain Using Ultrasound Technologies Coupled with Response Surface Methodology

Authors: Rosamaria Iadecola; R. Ciccoritti; B. Ceccantoni; A. Bellincontro; T. Amoriello

DOI: https://doi.org/10.3390/su14063309

Paper

Optimization of Spray Drying Parameters for White Dragon Fruit (Hylocereus undatus) Juice Powder using Response Surface Methodology (RSM)

N. Yusof; N. Adzahan; Kharidah Muhammad · 2020

Full title: Optimization of Spray Drying Parameters for White Dragon Fruit (Hylocereus undatus) Juice Powder using Response Surface Methodology (RSM)

Authors: N. Yusof; N. Adzahan; Kharidah Muhammad

DOI: https://doi.org/10.37231/myjas.2020.5.2.262

Paper

Self-optimisation and model-based design of experiments for developing a C–H activation flow process

Echtermeyer, Alexander Walter Wilhelm; Amar, Yehia; Zakrzewski, J. et al. · 2017

Full title: Self-optimisation and model-based design of experiments for developing a C–H activation flow process

Authors: Echtermeyer, Alexander Walter Wilhelm; Amar, Yehia; Zakrzewski, J.; Lapkin, Alexei A.

DOI: https://doi.org/10.3762/bjoc.13.18

Paper

Optimization of biodiesel production from spent cooking oil by fungal lipase using response surface methodology

S. O. Kareem; Olayinka Quadri Adio; M. Osho et al. · 2018

Full title: Optimization of biodiesel production from spent cooking oil by fungal lipase using response surface methodology

Authors: S. O. Kareem; Olayinka Quadri Adio; M. Osho; T. Banjo; S. O. Omeike

DOI: https://doi.org/10.4314/njb.v35i1.4

Paper

Statistical Approaches With Emphasis on Design of Experiments Applied to Chemical Processes

Silva, Valter · 2018

Full title: Statistical Approaches With Emphasis on Design of Experiments Applied to Chemical Processes

Authors: Silva, Valter

DOI: https://doi.org/10.5772/65616

Paper

Isolation of Total Saponins from Sapindus mukorossi Gaerth

Menghao Du; Sume Huang; Jinping Zhang et al. · 2014

Full title: Isolation of Total Saponins from Sapindus mukorossi Gaerth

Authors: Menghao Du; Sume Huang; Jinping Zhang; Jingwen Wang; Lisong Hu; Jingmin Jiang

DOI: https://doi.org/10.4236/ojf.2014.41004

Paper

Hybridization of Selected Nigerian Lignocellulosic Biomass Feedstocks for Bioethanol Production: Modeling and Optimization of Pretreatment and Fermentation Process Parameters Using Response Surface Methodology.

Awoyale, Adeolu A; Lokhat, David · 2021

Authors: Awoyale, Adeolu A; Lokhat, David

DOI: https://doi.org/10.5650/jos.ess21038

Paper

Optimization of ultrasonic-assisted enzymatic hydrolysis conditions for the production of antioxidant hydrolysates from porcine liver by using response surface methodology

Hui-Chuan Yu; F. Tan · 2017

Full title: Optimization of ultrasonic-assisted enzymatic hydrolysis conditions for the production of antioxidant hydrolysates from porcine liver by using response surface methodology

Authors: Hui-Chuan Yu; F. Tan

DOI: https://doi.org/10.5713/ajas.16.0807

Paper

Isolation and culture medium optimisation using one-factor-at-time and Response Surface Methodology on the biodegradation of the azo-dye amaranth

Noris Kartika Sari Islahuddin; M. Halmi; M. Manogaran et al. · 2017

Full title: Isolation and culture medium optimisation using one-factor-at-time and Response Surface Methodology on the biodegradation of the azo-dye amaranth

Authors: Noris Kartika Sari Islahuddin; M. Halmi; M. Manogaran; M. Shukor

DOI: https://doi.org/10.54987/bstr.v5i2.360

Paper

State-of-the-Art Review of Design of Experiments for Physics-Informed Deep Learning

Das, Sourav; Tesfamariam, Solomon · 2022

Full title: State-of-the-Art Review of Design of Experiments for Physics-Informed Deep Learning

Authors: Das, Sourav; Tesfamariam, Solomon

DOI: https://doi.org/10.48550/arxiv.2202.06416

Paper

A Taguchi Design of Experiments Approach for Untargeted Metabolomics Sample Preparation Optimization.

Garcia, Brianna M; Gouveia, Goncalo J; Shaver, Amanda O et al. · 2025

Full title: A Taguchi Design of Experiments Approach for Untargeted Metabolomics Sample Preparation Optimization.

Authors: Garcia, Brianna M; Gouveia, Goncalo J; Shaver, Amanda O; Borges, Ricardo M; Amster, I Jonathan; Edison, Arthur S; Iii, Franklin E Leach

DOI: https://doi.org/10.7171/3fc1f5fe.54585830

Paper

Application of Taguchi-Based Design of Experiments for Industrial Chemical Processes

Davis, Rahul; John, Pretesh · 2018

Full title: Application of Taguchi-Based Design of Experiments for Industrial Chemical Processes

Authors: Davis, Rahul; John, Pretesh

DOI: https://doi.org/10.5772/intechopen.69501

Paper

Use of design of experiments to optimize the production of microbial probiotic biofilms.

Speranza, Barbara; Liso, Arcangelo; Corbo, Maria Rosaria · 2018

Full title: Use of design of experiments to optimize the production of microbial probiotic biofilms.

Authors: Speranza, Barbara; Liso, Arcangelo; Corbo, Maria Rosaria

DOI: https://doi.org/10.7717/peerj.4826

Paper

A first course in design and analysis of experiments

Oehlert, Gary W. · 2000

Full title: A first course in design and analysis of experiments

Authors: Oehlert, Gary W.

Paper

Rotatable central composite design of experiments versus Taguchi method in the optimization of turning

Cukor, Goran; Jurković, Zoran; Sekulić, Milenko · 2011

Full title: Rotatable central composite design of experiments versus Taguchi method in the optimization of turning

Authors: Cukor, Goran; Jurković, Zoran; Sekulić, Milenko

Thesis

Optimisation of Multiple Response Processes Using Different Modeling Techniques

Silva, Messias Borges · 2023

Full title: Optimisation of Multiple Response Processes Using Different Modeling Techniques

Authors: Silva, Messias Borges

DOI: https://doi.org/10.12776/qip.v27i3.1899

Thesis

Design of Experiments (DoE) applied to Pharmaceutical and Analytical Quality by Design (QbD)

Lourenço, Felipe Rebello · 2018

Full title: Design of Experiments (DoE) applied to Pharmaceutical and Analytical Quality by Design (QbD)

Authors: Lourenço, Felipe Rebello

DOI: http://www.scielo.br/pdf/bjps/v54nspe/2175-9790-bjps-54-spe-e01006.pdf

Thesis

Design of experiments approach for the development of a validated method to determine the exenatide content in poly(lactide-co-glycolide) microspheres

Sheikhi, Mojgan; Sharifzadeh, Mohammad; Hennink, Wim E. et al. · 2023

Full title: Design of experiments approach for the development of a validated method to determine the exenatide content in poly(lactide-co-glycolide) microspheres

Authors: Sheikhi, Mojgan; Sharifzadeh, Mohammad; Hennink, Wim E.; Firoozpour, Loghman; Hajimahmoodi, Mannan; Khoshayand, Mohammad Reza; Shirangi, Mehrnoosh

DOI: https://dspace.library.uu.nl/handle/1874/435878

Thesis

Optimal experimental design for calibration of bioprocess models : a validated software toolbox

De Pauw, Dirk · 2005

Full title: Optimal experimental design for calibration of bioprocess models : a validated software toolbox

Authors: De Pauw, Dirk

DOI: https://biblio.ugent.be/publication/472062

Thesis

Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis

Advancing Cell Culture Engineering Through Mechanistic Model Optimization

O'Brien, Conor · 2020

Full title: Advancing Cell Culture Engineering Through Mechanistic Model Optimization

Authors: O'Brien, Conor

DOI: http://hdl.handle.net/11299/215059

Thesis

Development of a framework for descriptive and quantitative analysis of biotechnological processes

Carrillo Le Roux, Galo Antonio · 2025

Full title: Development of a framework for descriptive and quantitative analysis of biotechnological processes

Authors: Carrillo Le Roux, Galo Antonio

DOI: https://www.teses.usp.br/teses/disponiveis/3/3137/tde-25092025-104431/pt-br.php

Thesis

Algorithmic co-optimization of genetic constructs and growth conditions: application to 6-ACA, a potential nylon-6 precursor

Zhou, Hui; Vonk, Brenda; Roubos, Johannes A. et al. · 2016

Full title: Algorithmic co-optimization of genetic constructs and growth conditions: application to 6-ACA, a potential nylon-6 precursor

Authors: Zhou, Hui; Vonk, Brenda; Roubos, Johannes A.; Voigt, Christopher A.; Bovenberg, Roel A. L.

DOI: http://hdl.handle.net/1721.1/100578

Thesis

Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Murayyan, Abdulmonem · 2013

Full title: Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Authors: Murayyan, Abdulmonem

DOI: http://hdl.handle.net/10214/6604

Thesis

Bioprocess Strategies for the Production of Designer Rhamnolipid Biosurfactants

Nasser, Makary · 2025

Full title: Bioprocess Strategies for the Production of Designer Rhamnolipid Biosurfactants

Authors: Nasser, Makary

DOI: https://hdl.handle.net/10214/28811

Thesis

Rapid optimization of processes for the integrated purification of biopharmaceuticals

Crowell, Laura E; Rodriguez, Sergio A; Love, Kerry R et al. · 2021

Full title: Rapid optimization of processes for the integrated purification of biopharmaceuticals

Authors: Crowell, Laura E; Rodriguez, Sergio A; Love, Kerry R; Cramer, Steven M; Love, J Christopher

DOI: https://hdl.handle.net/1721.1/135519

Thesis

Design of experiments for model-based optimization

Singh, Prashant · 2016

Full title: Design of experiments for model-based optimization

Authors: Singh, Prashant

DOI: https://biblio.ugent.be/publication/7223691

Thesis

Tradespace as a decision making tool in bioprocess design

Tang, Yu-wen, S.M. Massachusetts Institute of Technology · 2017

Full title: Tradespace as a decision making tool in bioprocess design

Authors: Tang, Yu-wen, S.M. Massachusetts Institute of Technology

DOI: http://hdl.handle.net/1721.1/107362

Thesis

Computation and predictive modeling to increase efficiency and performance in cell line and bioprocess development

Baskerville-Bridges, Aaron(Aaron Davis) · 2020

Full title: Computation and predictive modeling to increase efficiency and performance in cell line and bioprocess development

Authors: Baskerville-Bridges, Aaron(Aaron Davis)

DOI: https://hdl.handle.net/1721.1/126944

Thesis

Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Hong, Moo Sun · 2022

Full title: Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Authors: Hong, Moo Sun

DOI: https://hdl.handle.net/1721.1/138943

Thesis

Model‐based control for column‐based continuous viral inactivation of biopharmaceuticals

Hong, Moo Sun; Lu, Amos E.; Ou, Rui Wen et al. · 2022

Full title: Model‐based control for column‐based continuous viral inactivation of biopharmaceuticals

Authors: Hong, Moo Sun; Lu, Amos E.; Ou, Rui Wen; Wolfrum, Jacqueline M.; Springs, Stacy L.; Sinskey, Anthony J.; Braatz, Richard D.

DOI: https://hdl.handle.net/1721.1/140434

Thesis

A central composite design to investigate antibody fragment production by Pichia pastoris

Chan, Joyce, M. Eng. Massachusetts Institute of Technology · 2006

Full title: A central composite design to investigate antibody fragment production by Pichia pastoris

Authors: Chan, Joyce, M. Eng. Massachusetts Institute of Technology

DOI: http://hdl.handle.net/1721.1/33872

Thesis

Dynamic flow experiments for Bayesian optimization of a single process objective

Florit, Federico; Nandiwale, Kakasaheb Y; Armstrong, Cameron T et al. · 2025

Full title: Dynamic flow experiments for Bayesian optimization of a single process objective

Authors: Florit, Federico; Nandiwale, Kakasaheb Y; Armstrong, Cameron T; Grohowalski, Katharina; Diaz, Angel R; Mustakis, Jason; Guinness, Steven M; Jensen, Klavs F

DOI: https://hdl.handle.net/1721.1/162459

Thesis

Bayesian Inference and Experimental Design of Combustion Kinetic Models

Chen, Huaibo · 2024

Full title: Bayesian Inference and Experimental Design of Combustion Kinetic Models

Authors: Chen, Huaibo

DOI: https://hdl.handle.net/1721.1/153682

Thesis

Optimal replicates for designed experiments under the online framework

Sudarsanam, Nandan; Pitchai Kannu, Balaji; Frey, Daniel · 2022

Full title: Optimal replicates for designed experiments under the online framework

Authors: Sudarsanam, Nandan; Pitchai Kannu, Balaji; Frey, Daniel

DOI: https://hdl.handle.net/1721.1/131804.2

Thesis

Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel et al. · 2025

Full title: Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Authors: Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel; Dang, Brendan; Wolffe, Lenna A; Atari, Adel; Tseng, Yuen-Yi; Love, J Christopher

DOI: https://hdl.handle.net/1721.1/163220

Thesis

Preemptive variation reduction in biologic drug substance manufacturing

Güereca Valdivia, Ismael · 2024

Full title: Preemptive variation reduction in biologic drug substance manufacturing

Authors: Güereca Valdivia, Ismael

DOI: https://hdl.handle.net/1721.1/155982

Thesis

Automated Optimization and Control of Modular Chemical Systems

Nikolakopoulou, Anastasia · 2022

Full title: Automated Optimization and Control of Modular Chemical Systems

Authors: Nikolakopoulou, Anastasia

DOI: https://hdl.handle.net/1721.1/143234

Thesis

Metabolomics and machine learning to assist biotechnology culture optimisation

Valencia Albornoz, Ricardo Gabriel · 2025

Full title: Metabolomics and machine learning to assist biotechnology culture optimisation

Authors: Valencia Albornoz, Ricardo Gabriel

DOI: https://hdl.handle.net/1842/43540

Thesis

Characterizing Hollow Fiber Membranes an Application of Sequential Design of Experiments

Nemetz, Leo Richard · 2023

Full title: Characterizing Hollow Fiber Membranes an Application of Sequential Design of Experiments

Authors: Nemetz, Leo Richard

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1678927636676011

Thesis

Sequential, Batch and Multi-Objective Bayesian Design of Experiments for Additive Manufacturing Processes

Harding, Guy · 2023

Full title: Sequential, Batch and Multi-Objective Bayesian Design of Experiments for Additive Manufacturing Processes

Authors: Harding, Guy

DOI: https://etheses.whiterose.ac.uk/id/eprint/33550/1/Updated%20Thesis%20GuyHarding.pdf

Thesis

Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Cosenza, Zachary Anthony · 2022

Full title: Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Authors: Cosenza, Zachary Anthony

DOI: https://escholarship.org/uc/item/119489fc

Thesis

Experimental planning and sequential kriging optimization using variable fidelity data

Huang, Deng · 2005

Full title: Experimental planning and sequential kriging optimization using variable fidelity data

Authors: Huang, Deng

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1110297243

Thesis

Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection-A Simulation Study

Hernandez Rodriguez, Tanja; Morerod, Sophie; Poertner, Ralf et al. · 2021

Full title: Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection-A Simulation Study

Authors: Hernandez Rodriguez, Tanja; Morerod, Sophie; Poertner, Ralf; Wurm, Florian M.; Frahm, Bjorn

DOI: https://infoscience.epfl.ch/handle/20.500.14299/180009

Thesis

Modern design of experiments methods for screening and experimentations with mixture and qualitative variables

Chantarat, Navara · 2003

Full title: Modern design of experiments methods for screening and experimentations with mixture and qualitative variables

Authors: Chantarat, Navara

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1064198056

Thesis

Impact of Dispersion Effect on Model Selection for Definitive Screening Designs

Torsu, Blessing Anarfi-Dziwornu · 2023

Full title: Impact of Dispersion Effect on Model Selection for Definitive Screening Designs

Authors: Torsu, Blessing Anarfi-Dziwornu

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1683655390292968

Thesis

White-Box Approaches to Cell Culture Media Optimization for Cultivated Meat

O'Neill, Edward N · 2024

Full title: White-Box Approaches to Cell Culture Media Optimization for Cultivated Meat

Authors: O'Neill, Edward N

DOI: https://escholarship.org/uc/item/9920t5d7

Thesis

Optimisation of plasma sprayed hydroxyapatite coatings using a design of experiments approach

Kuntin, David · 2020

Full title: Optimisation of plasma sprayed hydroxyapatite coatings using a design of experiments approach

Authors: Kuntin, David

DOI: https://etheses.whiterose.ac.uk/id/eprint/28155/1/Kuntin_201043602_Thesis.pdf

Thesis

Pharmaceutical process optimisation: Decision support under high uncertainty

Pham, TD; Manapragada, C; Rajan, N et al. · 2022

Full title: Pharmaceutical process optimisation: Decision support under high uncertainty

Authors: Pham, TD; Manapragada, C; Rajan, N; Aickelin, U

DOI: https://hdl.handle.net/11343/324485

Thesis

Characterization of the mechanism of action of spin-filters for animal cell perfusion cultures

Vallez-Chetreanu, Florentina · 2006

Full title: Characterization of the mechanism of action of spin-filters for animal cell perfusion cultures

Authors: Vallez-Chetreanu, Florentina

DOI: https://infoscience.epfl.ch/handle/20.500.14299/224152

Thesis

Response improvement in complex experiments by co-information composite likelihood optimization

Ferrari, D; Borrotti, M; De March, D · 2021

Full title: Response improvement in complex experiments by co-information composite likelihood optimization

Authors: Ferrari, D; Borrotti, M; De March, D

DOI: https://hdl.handle.net/11343/282753

Thesis

Development of an integrated platform for the production of recombinant biopharmaceuticals

Segarra, Camille · 2013

Full title: Development of an integrated platform for the production of recombinant biopharmaceuticals

Authors: Segarra, Camille

DOI: https://etheses.whiterose.ac.uk/id/eprint/4147/1/Segarra_Thesis_PostCorrections.pdf

Thesis

Capturing prediction uncertainty in upstream cell culture models using conformal prediction and Gaussian processes

Pham, TD; Aickelin, U; Bassett, R · 2024

Full title: Capturing prediction uncertainty in upstream cell culture models using conformal prediction and Gaussian processes

Authors: Pham, TD; Aickelin, U; Bassett, R

DOI: https://hdl.handle.net/11343/339627

Thesis

Optimal Bayesian design for model discrimination via classification

Hainy, M; Price, DJ; Restif, O et al. · 2022

Full title: Optimal Bayesian design for model discrimination via classification

Authors: Hainy, M; Price, DJ; Restif, O; Drovandi, C

DOI: https://hdl.handle.net/11343/306676

Thesis

Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture

Shariatzadeh, M; Lopes, AG; Glen, KE et al. · 2021

Full title: Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture

Authors: Shariatzadeh, M; Lopes, AG; Glen, KE; Sinclair, A; Thomas, RJ

DOI: https://hdl.handle.net/11343/289743

Thesis

Predictive models for upstream mammalian cell culture development: a review

Yatipanthalawa, BS; Gras, SL · 2023

Full title: Predictive models for upstream mammalian cell culture development: a review

Authors: Yatipanthalawa, BS; Gras, SL

DOI: https://hdl.handle.net/11343/339523

Thesis

Application of mechanistic modelling in membrane and fiber chromatography for purification of biotherapeutics — A review

Qu, Y; Baker, I; Black, J et al. · 2024

Full title: Application of mechanistic modelling in membrane and fiber chromatography for purification of biotherapeutics — A review

Authors: Qu, Y; Baker, I; Black, J; Fabri, L; Gras, SL; Lenhoff, AM; Kentish, SE

DOI: https://hdl.handle.net/11343/340258

Thesis

A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments

Karimi Alavijeh, M; Lee, YY; Gras, SL · 2024

Full title: A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments

Authors: Karimi Alavijeh, M; Lee, YY; Gras, SL

DOI: https://hdl.handle.net/11343/351093

Thesis

Tools for digital twins in continuous downstream processing

Tallvod, Simon · 2023

Full title: Tools for digital twins in continuous downstream processing

Authors: Tallvod, Simon

DOI: https://lup.lub.lu.se/record/191aa4b8-990d-47f1-a248-68bfb57ff330

Thesis

A Model-based Approach to Evaluating Chromatography Capture Steps

Ulmestig, Jakob · 2017

Full title: A Model-based Approach to Evaluating Chromatography Capture Steps

Authors: Ulmestig, Jakob

DOI: http://lup.lub.lu.se/student-papers/record/8928249

Thesis

Efficacy of robust regression applied to fractional factorial treatment structures.

McCants, Michael · 2011

Full title: Efficacy of robust regression applied to fractional factorial treatment structures.

Authors: McCants, Michael

DOI: http://hdl.handle.net/2097/9260

Thesis

Design and Control of Integrated Continuous Processes for the Purification of Biopharmaceuticals

Gomis Fons, Joaquin · 2022

Full title: Design and Control of Integrated Continuous Processes for the Purification of Biopharmaceuticals

Authors: Gomis Fons, Joaquin

DOI: https://lup.lub.lu.se/record/7de201f7-6a1b-4772-b3d1-e5d221e9515c

Thesis

Digitalization in biopharmaceutical downstream processes

Espinoza, Daniel · 2024

Full title: Digitalization in biopharmaceutical downstream processes

Authors: Espinoza, Daniel

DOI: https://lup.lub.lu.se/record/f936d3e3-244e-4f3b-812a-6866d82a1eee

Thesis

Optimization of batch adsorption and fixed-bed adsorption of vanillin onto resin H103

Abu Samah, Rozaimi · 2016

Full title: Optimization of batch adsorption and fixed-bed adsorption of vanillin onto resin H103

Authors: Abu Samah, Rozaimi

DOI: http://psasir.upm.edu.my/id/eprint/112951/1/112951.pdf

Thesis

Biomanufacturing of an organic solvent tolerant and thermostable lipase by recombinant E. coli

Nelofer, Rubina · 2012

Full title: Biomanufacturing of an organic solvent tolerant and thermostable lipase by recombinant E. coli

Authors: Nelofer, Rubina

DOI: http://psasir.upm.edu.my/id/eprint/33307/1/FBSB%202012%2019R.pdf

Thesis

A MINE alternative to D-optimal designs for the linear model

Bouffier, Amanda Marie · 2024

Full title: A MINE alternative to D-optimal designs for the linear model

Authors: Bouffier, Amanda Marie

DOI: https://openscholar.uga.edu/record/20247/files/bouffier_amanda_m_201308_ms.pdf

Thesis

Development of an integrated fermentation pervaporation model for bioethanol production

Hamid, Zentou · 2021

Full title: Development of an integrated fermentation pervaporation model for bioethanol production

Authors: Hamid, Zentou

DOI: http://psasir.upm.edu.my/id/eprint/98171/1/FK%202021%2087%20-%20IR.pdf

Thesis

Optimization of a centrifugal electrospinning process using response surface methods and artificial neural networks

Greenawalt, Frank E., author; Duff, William S., advisor; Bradley, Thomas H., committee member et al. · 2007

Full title: Optimization of a centrifugal electrospinning process using response surface methods and artificial neural networks

Authors: Greenawalt, Frank E., author; Duff, William S., advisor; Bradley, Thomas H., committee member; Labadie, John W., committee member; Popat, Ketul C., committee member

DOI: http://hdl.handle.net/10217/82600

Thesis

Optimal designs for generalized linear models

Tan, Xijue · 2024

Full title: Optimal designs for generalized linear models

Authors: Tan, Xijue

DOI: https://openscholar.uga.edu/record/12986/files/tan_xijue_201505_phd.pdf

Thesis

Optimal Physical Experiments and Surrogates for Complex Computer Models

Jankar, Jeevan · 2025

Full title: Optimal Physical Experiments and Surrogates for Complex Computer Models

Authors: Jankar, Jeevan

DOI: https://openscholar.uga.edu/record/27335/files/Jankar_uga_0077E_16588.pdf

Thesis

Systematic sequencing of factorial experiments as an alternative to the random order

Oprime, Pedro Carlos; Pureza, Vitória Maria Miranda; De Oliveira, Samuel Conceição [UNESP] · 2018

Full title: Systematic sequencing of factorial experiments as an alternative to the random order

Authors: Oprime, Pedro Carlos; Pureza, Vitória Maria Miranda; De Oliveira, Samuel Conceição [UNESP]

DOI: http://dx.doi.org/10.1590/0104-530X1266-16

Thesis

Fundamental concepts and recent applications of factorial statistical designs

Mainardi, Pedro Henrique [UNESP]; Bidoia, Ederio Dino [UNESP] · 2022

Full title: Fundamental concepts and recent applications of factorial statistical designs

Authors: Mainardi, Pedro Henrique [UNESP]; Bidoia, Ederio Dino [UNESP]

DOI: http://hdl.handle.net/11449/217478

Thesis

Modelos estatísticos fatoriais: conceitos e aplicações

Mainardi, Pedro Henrique [UNESP]; Bidoia, Ederio Dino [UNESP] · 2021

Full title: Modelos estatísticos fatoriais: conceitos e aplicações

Authors: Mainardi, Pedro Henrique [UNESP]; Bidoia, Ederio Dino [UNESP]

DOI: http://hdl.handle.net/11449/214146

Thesis

An application of sequential experimental design in catalyst kinetic studies

Agarwal, Anil K. (Anil Kumar) · 1994

Full title: An application of sequential experimental design in catalyst kinetic studies

Authors: Agarwal, Anil K. (Anil Kumar)

DOI: http://hdl.handle.net/2123/10235

Thesis

Quality by design framework applied to GMMA purification

Giannelli, Carlo; Necchi, Francesca; Palmieri, Elena et al. · 2024

Full title: Quality by design framework applied to GMMA purification

Authors: Giannelli, Carlo; Necchi, Francesca; Palmieri, Elena; Oldrini, Davide; Ricchetti, Beatrice; Papathanasiou, Maria M; Kis, Zoltan; Kontoravdi, Cleo; Campa, Cristiana; Micoli, Francesca

DOI: https://link.springer.com/article/10.1208/s12248-024-00902-0

Thesis

Discrete and mixed-variable experimental design with surrogate-based approach

Zhu, Mengjia; Mroz, Austin; Gui, Lingfeng et al. · 2024

Full title: Discrete and mixed-variable experimental design with surrogate-based approach

Authors: Zhu, Mengjia; Mroz, Austin; Gui, Lingfeng; Jelfs, Kim E; Bemporad, Alberto; del Río Chanona, Ehecatl Antonio; Lee, Ye Seol

DOI: http://dx.doi.org/10.1039/d4dd00113c

Thesis

Bayesian Optimization with Dimension Scheduling: Application to Biological Systems

Ulmasov, D; Baroukh, C; Chachuat, B et al. · 2016

Full title: Bayesian Optimization with Dimension Scheduling: Application to Biological Systems

Authors: Ulmasov, D; Baroukh, C; Chachuat, B; Deisenroth, MP; Misener, R

DOI: http://arxiv.org/abs/1511.05385v1

Thesis

Design of Experiments for Verifying Biomolecular Networks

Sedgwick, Ruby; Goertz, John; Stevens, Molly et al. · 2020

Full title: Design of Experiments for Verifying Biomolecular Networks

Authors: Sedgwick, Ruby; Goertz, John; Stevens, Molly; Misener, Ruth; Wilk, Mark van der

DOI: http://arxiv.org/abs/2011.10575v2

Thesis

GPdoemd: a python package for design of experiments for model discrimination

Olofsson, Simon; Misener, Ruth · 2018

Full title: GPdoemd: a python package for design of experiments for model discrimination

Authors: Olofsson, Simon; Misener, Ruth

DOI: http://arxiv.org/abs/1810.02561v1

Thesis

Safe real-time optimization using multi-fidelity guassian processes

Petsagkourakis, Panagiotis; Chachuat, Benoit; Rio-Chanona, Ehecatl Antonio del · 2022

Full title: Safe real-time optimization using multi-fidelity guassian processes

Authors: Petsagkourakis, Panagiotis; Chachuat, Benoit; Rio-Chanona, Ehecatl Antonio del

DOI: http://arxiv.org/abs/2111.05589v1

Thesis

Bayesian hierarchical modelling of dual response surfaces

Chen, Younan · 2014

Full title: Bayesian hierarchical modelling of dual response surfaces

Authors: Chen, Younan

DOI: http://hdl.handle.net/10919/29924

Thesis

Bioprocess efficiency as a roadmap to establish Pichia pastoris as a reliable cell factory

Ponte Font, Xavier · 2017

Full title: Bioprocess efficiency as a roadmap to establish Pichia pastoris as a reliable cell factory

Authors: Ponte Font, Xavier

DOI: http://hdl.handle.net/10803/457712

Thesis

Optimal Experimental Design for Poisson Impaired Reproduction Studies

Huffman, Jennifer Wade · 2014

Full title: Optimal Experimental Design for Poisson Impaired Reproduction Studies

Authors: Huffman, Jennifer Wade

DOI: http://hdl.handle.net/10919/30751

Thesis

Machine Learning and Multivariate Statistics for Optimizing Bioprocessing and Polyolefin Manufacturing

Agarwal, Aman · 2022

Full title: Machine Learning and Multivariate Statistics for Optimizing Bioprocessing and Polyolefin Manufacturing

Authors: Agarwal, Aman

DOI: http://hdl.handle.net/10919/107480

Thesis

Probabilistic framework for optimal experimental campaigns in the presence of operational constraints

Kusumo, Kennedy; Kuriyan, kamal; Vaidyaraman, Shankar et al. · 2022

Full title: Probabilistic framework for optimal experimental campaigns in the presence of operational constraints

Authors: Kusumo, Kennedy; Kuriyan, kamal; Vaidyaraman, Shankar; Garcia Munoz, Salvador; Shah, Nilay; Chachuat, Benoit

DOI: https://pubs.rsc.org/en/content/articlelanding/2022/RE/D1RE00465D

Thesis

Neural Networks in Bioprocessing and Chemical Engineering

Baughman, D. Richard · 2014

Full title: Neural Networks in Bioprocessing and Chemical Engineering

Authors: Baughman, D. Richard

DOI: http://hdl.handle.net/10919/29061

Thesis

Data Driven Surrogate Based Optimization in the Problem Solving Environment WBCSim

Deshpande, Shubhangi · 2014

Full title: Data Driven Surrogate Based Optimization in the Problem Solving Environment WBCSim

Authors: Deshpande, Shubhangi

DOI: http://hdl.handle.net/10919/35901

Thesis

Bayesian Optimization for Engineering Design and Quality Control of Manufacturing Systems

AlBahar, Areej Ahmad · 2022

Full title: Bayesian Optimization for Engineering Design and Quality Control of Manufacturing Systems

Authors: AlBahar, Areej Ahmad

DOI: http://hdl.handle.net/10919/109668

Thesis

Bayesian D-Optimal Design for Generalized Linear Models

Zhang, Ying · 2014

Full title: Bayesian D-Optimal Design for Generalized Linear Models

Authors: Zhang, Ying

DOI: http://hdl.handle.net/10919/30147

Thesis

Adapting Response Surface Methods for the Optimization of Black-Box Systems

Zielinski, Jacob Jonathan · 2014

Full title: Adapting Response Surface Methods for the Optimization of Black-Box Systems

Authors: Zielinski, Jacob Jonathan

DOI: http://hdl.handle.net/10919/39295

Thesis

Enhancing the Functionality of a Microscale Bioreactor System as an Industrial Process Development Tool for Mammalian Perfusion Culture

Sewell, David J; Turner, Richard; Field, Ray et al. · 2019

Full title: Enhancing the Functionality of a Microscale Bioreactor System as an Industrial Process Development Tool for Mammalian Perfusion Culture

Authors: Sewell, David J; Turner, Richard; Field, Ray; Holmes, William; Pradhan, Rahul; Spencer, Christopher; Oliver, Stephen; Slater, Nigel; Dikicioglu, Duygu

DOI: https://www.repository.cam.ac.uk/handle/1810/289313

Thesis

Data Analytics and Machine Learning Applications in Fermentation Processes and Molecular Property Prediction

Nguyen, Xuan Dung · 2025

Full title: Data Analytics and Machine Learning Applications in Fermentation Processes and Molecular Property Prediction

Authors: Nguyen, Xuan Dung

DOI: https://hdl.handle.net/10919/134219

Thesis

Bayesian Two Stage Design Under Model Uncertainty

Neff, Angela R. · 2014

Full title: Bayesian Two Stage Design Under Model Uncertainty

Authors: Neff, Angela R.

DOI: http://hdl.handle.net/10919/30303

Thesis

Simulation and Comparison of Operational Modes in Simulated Moving Bed Chromatography and Gas-Phase Adsorptive Separation

Yu, Yueying · 2017

Full title: Simulation and Comparison of Operational Modes in Simulated Moving Bed Chromatography and Gas-Phase Adsorptive Separation

Authors: Yu, Yueying

DOI: http://hdl.handle.net/10919/78319

Thesis

General Weighted Optimality of Designed Experiments

Stallings, Jonathan W. · 2015

Full title: General Weighted Optimality of Designed Experiments

Authors: Stallings, Jonathan W.

DOI: http://hdl.handle.net/10919/56949

Thesis

Optimal experimental designs for two-variable logistic regression models

Jia, Yan · 2014

Full title: Optimal experimental designs for two-variable logistic regression models

Authors: Jia, Yan

DOI: http://hdl.handle.net/10919/38044

Thesis

Studies in process optimisation

Hiep, Luu Tien · 1972

Full title: Studies in process optimisation

Authors: Hiep, Luu Tien

DOI: http://hdl.handle.net/1959.4/57733

Thesis

Quantifying the maximum possible improvement in $$2^{k}$$ 2 k experiments

Sudarsanam, Nandan; Kumar, Anusha; Frey, Daniel D. · 2022

Full title: Quantifying the maximum possible improvement in $$2^{k}$$ 2 k experiments

Authors: Sudarsanam, Nandan; Kumar, Anusha; Frey, Daniel D.

DOI: https://hdl.handle.net/1721.1/142959

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us-7510864-b2

· 2009

Full title: us-7510864-b2

Patent

us-8571689-b2

· 2013

Full title: us-8571689-b2

Patent

us-8086327-b2

· 2011

Full title: us-8086327-b2

Patent

us-7062417-b2

· 2006

Full title: us-7062417-b2

Patent

us-8412356-b2

· 2013

Full title: us-8412356-b2

Patent

us-7877154-b2

· 2011

Full title: us-7877154-b2

Patent

us-7507579-b2

· 2009

Full title: us-7507579-b2

Patent

us-9046882-b2

· 2015

Full title: us-9046882-b2

Patent

us-8818562-b2

· 2014

Full title: us-8818562-b2

Patent

us-9454640-b2

· 2016

Full title: us-9454640-b2

Patent

us-9659111-b2

· 2017

Full title: us-9659111-b2

3. Authors & Profiles

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4. Email Outreach

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