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Impact Of Temperature Shift Timing On Cho Cell Cul

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Paper Advances in recombinant antibody manufacturing

Kunert, Renate; Reinhart, David · 2016 · Applied Microbiology and Biotechnology · DOI

Full title: Advances in recombinant antibody manufacturing

Authors: Kunert, Renate; Reinhart, David

Year: 2016

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-016-7388-9

Paper Optimum blue light exposure: a means to increase cell-specific productivity in Chinese hamster ovary cells.

Föller, Stefanie; Regett, Niklas; Lataster, Levin et al. · 2024 · Applied microbiology and biotechnology · DOI

Full title: Optimum blue light exposure: a means to increase cell-specific productivity in Chinese hamster ovary cells.

Authors: Föller, Stefanie; Regett, Niklas; Lataster, Levin; Radziwill, Gerald; Takors, Ralf

Year: 2024

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-024-13363-4

Paper Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells.

Sumitomo, Yasuhiko; Higashitsuji, Hiroaki; Higashitsuji, Hisako et al. · 2012 · BMC biotechnology · DOI

Full title: Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells.

Authors: Sumitomo, Yasuhiko; Higashitsuji, Hiroaki; Higashitsuji, Hisako; Liu, Yu; Fujita, Takanori; Sakurai, Toshiharu; Candeias, Marco M; Itoh, Katsuhiko; Chiba, Tsutomu; Fujita, Jun

Year: 2012

Venue: BMC biotechnology

DOI: https://doi.org/10.1186/1472-6750-12-72

Paper Differential protein expression following low temperature culture of suspension CHO-K1 cells.

Kumar, Niraj; Gammell, Patrick; Meleady, Paula et al. · 2008 · BMC biotechnology · DOI

Full title: Differential protein expression following low temperature culture of suspension CHO-K1 cells.

Authors: Kumar, Niraj; Gammell, Patrick; Meleady, Paula; Henry, Michael; Clynes, Martin

Year: 2008

Venue: BMC biotechnology

DOI: https://doi.org/10.1186/1472-6750-8-42

Paper Identification of a novel temperature sensitive promoter in CHO cells.

Thaisuchat, Haruthai; Baumann, Martina; Pontiller, Jens et al. · 2011 · BMC biotechnology · DOI

Full title: Identification of a novel temperature sensitive promoter in CHO cells.

Authors: Thaisuchat, Haruthai; Baumann, Martina; Pontiller, Jens; Hesse, Friedemann; Ernst, Wolfgang

Year: 2011

Venue: BMC biotechnology

DOI: https://doi.org/10.1186/1472-6750-11-51

Paper Development of an intensified fed-batch production platform with doubled titers using N-1 perfusion seed for cell culture manufacturing

Xu, Jianlin; Rehmann, Matthew S.; Xu, Mengmeng et al. · 2020 · Bioresources and Bioprocessing · DOI

Full title: Development of an intensified fed-batch production platform with doubled titers using N-1 perfusion seed for cell culture manufacturing

Authors: Xu, Jianlin; Rehmann, Matthew S.; Xu, Mengmeng; Zheng, Shun; Hill, Charles G.; He, Qin; Borys, Michael; Li, Zheng Jian

Year: 2020

Venue: Bioresources and Bioprocessing

DOI: https://doi.org/10.1186/s40643-020-00304-y

Paper LDH-C can be differentially expressed during fermentation of CHO cells.

Szperalski, Berthold; Jung, Christine; Shao, Zhixin et al. · 2011 · BMC proceedings · DOI

Full title: LDH-C can be differentially expressed during fermentation of CHO cells.

Authors: Szperalski, Berthold; Jung, Christine; Shao, Zhixin; Kantardjieff, Anne; Hu, Wei-Shou

Year: 2011

Venue: BMC proceedings

DOI: https://doi.org/10.1186/1753-6561-5-S8-P107

Paper ¹H NMR spectroscopy profiling of metabolic reprogramming of Chinese hamster ovary cells upon a temperature shift during culture.

Wagstaff, Jane L; Masterton, Rosalyn J; Povey, Jane F et al. · 2013 · PloS one · DOI

Full title: ¹H NMR spectroscopy profiling of metabolic reprogramming of Chinese hamster ovary cells upon a temperature shift during culture.

Authors: Wagstaff, Jane L; Masterton, Rosalyn J; Povey, Jane F; Smales, C Mark; Howard, Mark J

Year: 2013

Venue: PloS one

DOI: https://doi.org/10.1371/journal.pone.0077195

Paper Improved functional expression of human cardiac kv1.5 channels and trafficking-defective mutants by low temperature treatment.

Ding, Wei-Guang; Xie, Yu; Toyoda, Futoshi et al. · 2014 · PloS one · DOI

Full title: Improved functional expression of human cardiac kv1.5 channels and trafficking-defective mutants by low temperature treatment.

Authors: Ding, Wei-Guang; Xie, Yu; Toyoda, Futoshi; Matsuura, Hiroshi

Year: 2014

Venue: PloS one

DOI: https://doi.org/10.1371/journal.pone.0092923

Paper Differential effect of culture temperature and specific growth rate on CHO cell behavior in chemostat culture.

Vergara, Mauricio; Becerra, Silvana; Berrios, Julio et al. · 2014 · PloS one · DOI

Full title: Differential effect of culture temperature and specific growth rate on CHO cell behavior in chemostat culture.

Authors: Vergara, Mauricio; Becerra, Silvana; Berrios, Julio; Osses, Nelson; Reyes, Juan; Rodríguez-Moyá, María; Gonzalez, Ramon; Altamirano, Claudia

Year: 2014

Venue: PloS one

DOI: https://doi.org/10.1371/journal.pone.0093865

Paper Therapeutic Fc fusion protein misfolding: A three-phasic cultivation experimental design.

Ghorbani Aghdam, Atefeh; Moradhaseli, Saeed; Jafari, Farnoush et al. · 2019 · PloS one · DOI

Full title: Therapeutic Fc fusion protein misfolding: A three-phasic cultivation experimental design.

Authors: Ghorbani Aghdam, Atefeh; Moradhaseli, Saeed; Jafari, Farnoush; Motahari, Paria; Samavat, Sepideh; Mahboudi, Rasoul; Maleknia, Shayan

Year: 2019

Venue: PloS one

DOI: https://doi.org/10.1371/journal.pone.0210712

Paper Decoupling Growth and Protein Production in CHO Cells: A Targeted Approach.

Donaldson, James S; Dale, Matthew P; Rosser, Susan J · 2021 · Frontiers in bioengineering and biotechnology · DOI

Full title: Decoupling Growth and Protein Production in CHO Cells: A Targeted Approach.

Authors: Donaldson, James S; Dale, Matthew P; Rosser, Susan J

Year: 2021

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2021.658325

Paper Endoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat Cultures.

Vergara, Mauricio; Berrios, Julio; Martínez, Irene et al. · 2015 · PloS one · DOI

Full title: Endoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat Cultures.

Authors: Vergara, Mauricio; Berrios, Julio; Martínez, Irene; Díaz-Barrera, Alvaro; Acevedo, Cristian; Reyes, Juan G; Gonzalez, Ramon; Altamirano, Claudia

Year: 2015

Venue: PloS one

DOI: https://doi.org/10.1371/journal.pone.0144224

Paper Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Productivity and Product Quality.

Strasser, Lisa; Farrell, Amy; Ho, Jenny T C et al. · 2021 · Frontiers in bioengineering and biotechnology · DOI

Full title: Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Productivity and Product Quality.

Authors: Strasser, Lisa; Farrell, Amy; Ho, Jenny T C; Scheffler, Kai; Cook, Ken; Pankert, Patrick; Mowlds, Peter; Viner, Rosa; Karger, Barry L; Bones, Jonathan

Year: 2021

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2021.569045

Paper Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells.

Torres, Mauro; Zúñiga, Roberto; Gutierrez, Matias et al. · 2018 · PloS one · DOI

Full title: Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells.

Authors: Torres, Mauro; Zúñiga, Roberto; Gutierrez, Matias; Vergara, Mauricio; Collazo, Norberto; Reyes, Juan; Berrios, Julio; Aguillon, Juan Carlos; Molina, Maria Carmen; Altamirano, Claudia

Year: 2018

Venue: PloS one

DOI: https://doi.org/10.1371/journal.pone.0194510

Paper High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells.

Vergara, Mauricio; Torres, Mauro; Müller, Andrea et al. · 2018 · PloS one · DOI

Full title: High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells.

Authors: Vergara, Mauricio; Torres, Mauro; Müller, Andrea; Avello, Verónica; Acevedo, Cristian; Berrios, Julio; Reyes, Juan G; Valdez-Cruz, Norma A; Altamirano, Claudia

Year: 2018

Venue: PloS one

DOI: https://doi.org/10.1371/journal.pone.0202098

Paper Enhancing productivity of Chinese hamster ovary (CHO) cells: synergistic strategies combining low-temperature culture and mTORC1 signaling engineering.

Shahabi, Farzaneh; Abdoli, Shahriyar; Bazi, Zahra et al. · 2023 · Frontiers in bioengineering and biotechnology · DOI

Full title: Enhancing productivity of Chinese hamster ovary (CHO) cells: synergistic strategies combining low-temperature culture and mTORC1 signaling engineering.

Authors: Shahabi, Farzaneh; Abdoli, Shahriyar; Bazi, Zahra; Shamsabadi, Fatemeh; Yamchi, Ahad; Shahbazi, Majid

Year: 2023

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2023.1268048

Paper High-Level Production of scFv-Fc Antibody Using an Artificial Promoter System with Transcriptional Positive Feedback Loop of Transactivator in CHO Cells.

Ying, Binbin; Kawabe, Yoshinori; Zheng, Feiyang et al. · 2023 · Cells · DOI

Full title: High-Level Production of scFv-Fc Antibody Using an Artificial Promoter System with Transcriptional Positive Feedback Loop of Transactivator in CHO Cells.

Authors: Ying, Binbin; Kawabe, Yoshinori; Zheng, Feiyang; Amamoto, Yuki; Kamihira, Masamichi

Year: 2023

Venue: Cells

DOI: https://doi.org/10.3390/cells12222638

Paper Reduced Culture Temperature Differentially Affects Expression and Biophysical Properties of Monoclonal Antibody Variants.

Mason, Megan; Sweeney, Bernadette; Cain, Katharine et al. · 2014 · Antibodies (Basel, Switzerland) · DOI

Full title: Reduced Culture Temperature Differentially Affects Expression and Biophysical Properties of Monoclonal Antibody Variants.

Authors: Mason, Megan; Sweeney, Bernadette; Cain, Katharine; Stephens, Paul; Sharfstein, Susan T

Year: 2014

Venue: Antibodies (Basel, Switzerland)

DOI: https://doi.org/10.3390/antib3030253

Paper Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments.

Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald et al. · 2021 · Frontiers in bioengineering and biotechnology · DOI

Full title: Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments.

Authors: Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald; Sissolak, Bernhard

Year: 2021

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2021.740215

Paper The Effect of Culture Temperature on Recombinant IFN-γ Production and Quality

Fox, Steven R.; Yap, Miranda G.S.; Wang, Daniel I. C. · 2004 · DSpace@MIT (Massachusetts Institute of Technology)

Full title: The Effect of Culture Temperature on Recombinant IFN-γ Production and Quality

Authors: Fox, Steven R.; Yap, Miranda G.S.; Wang, Daniel I. C.

Year: 2004

Venue: DSpace@MIT (Massachusetts Institute of Technology)

Thesis Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76323

Thesis Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells

Meuwly, F.; von Stockar, U.; Kadouri, A. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells

Authors: Meuwly, F.; von Stockar, U.; Kadouri, A.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226104

Thesis Impact on product quality of high productive GS-CHO cell lines.

Perani, A; Gloria, B; Wang, D et al. · 2022 · University of Melbourne · DOI

Full title: Impact on product quality of high productive GS-CHO cell lines.

Authors: Perani, A; Gloria, B; Wang, D; Murphy, R; Singh, HK; Smyth, FE; Scott, AM

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/303930

Thesis Variations in critical quality attributes (CQAs) on therapeutic monoclonal antibodies (mAbs) due to cultivation conditions, storage conditions and external stress-factors

Nash, Felicia; Sannum, Emma · 2024 · Lund University Student Papers · DOI

Full title: Variations in critical quality attributes (CQAs) on therapeutic monoclonal antibodies (mAbs) due to cultivation conditions, storage conditions and external stress-factors

Authors: Nash, Felicia; Sannum, Emma

Year: 2024

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9170581

Thesis FIA-Based Process Monitoring in Simulated Bioreactor for Monoclonal Antibody Production

Fernandez Alcantara, Leonardo Renzo · 2025 · Lund University Student Papers · DOI

Full title: FIA-Based Process Monitoring in Simulated Bioreactor for Monoclonal Antibody Production

Authors: Fernandez Alcantara, Leonardo Renzo

Year: 2025

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9188201

Thesis Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022 · KTH Royal Institute of Technology · DOI

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

Year: 2022

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis Transcriptome analysis in mammalian cell culture: Applications in process development and characterization.

Kantardjieff, Anne · 2011 · University of Minnesota - Digital Conservancy · DOI

Full title: Transcriptome analysis in mammalian cell culture: Applications in process development and characterization.

Authors: Kantardjieff, Anne

Year: 2011

Venue: University of Minnesota - Digital Conservancy

DOI: http://purl.umn.edu/116703

Thesis The Assessment of MAb Quality and Quantity

Drouillard, Gerald · 2015 · University of Guelph · DOI

Full title: The Assessment of MAb Quality and Quantity

Authors: Drouillard, Gerald

Year: 2015

Venue: University of Guelph

DOI: http://hdl.handle.net/10214/8743

Thesis Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Zhang, Liang · 2020 · KTH Royal Institute of Technology · DOI

Full title: Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Authors: Zhang, Liang

Year: 2020

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-273343

Thesis A computational framework for predicting CHO cell culture performance in bioreactors

Cárcamo Behrens, Martín. · 2019 · Massachusetts Institute of Technology (MIT) · DOI

Full title: A computational framework for predicting CHO cell culture performance in bioreactors

Authors: Cárcamo Behrens, Martín.

Year: 2019

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/123055

Thesis Active hypothermic growth : a novel means for increasing total recombinant protein production by CHO cells

Fox, Stephen Richard · 2008 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Active hypothermic growth : a novel means for increasing total recombinant protein production by CHO cells

Authors: Fox, Stephen Richard

Year: 2008

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://dspace.mit.edu/handle/1721.1/32333

Thesis Glycosylation site occupancy heterogeneity in Chinese hamster ovary cell culture

Nyberg, Gregg B. (Gregg Bartell), 1970- · 2005 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Glycosylation site occupancy heterogeneity in Chinese hamster ovary cell culture

Authors: Nyberg, Gregg B. (Gregg Bartell), 1970-

Year: 2005

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/28190

Thesis Quantitative Analysis of Proteome Dynamics in Chinese Hamster Ovary cells

Florczak, Beata D · 2019 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Quantitative Analysis of Proteome Dynamics in Chinese Hamster Ovary cells

Authors: Florczak, Beata D

Year: 2019

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/25823/1/B.Florczak_thesis.pdf

Thesis Cell Line and Process Development for Improved Transient Production of a "Difficult-to-Express" Fusion Protein by CHO Cells

Johari, YB · 2015 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Cell Line and Process Development for Improved Transient Production of a "Difficult-to-Express" Fusion Protein by CHO Cells

Authors: Johari, YB

Year: 2015

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/9265/1/PhD%20thesis%20-%20YB%20Johari%20%5BFINAL%5D.pdf

Thesis Combining ion mobility spectrometry and cryogenic ion spectroscopy with enzymatic digestion/synthesis for the study of N-linked glycans

Märki, Irina · 2023 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Combining ion mobility spectrometry and cryogenic ion spectroscopy with enzymatic digestion/synthesis for the study of N-linked glycans

Authors: Märki, Irina

Year: 2023

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/194229

Thesis Transient recombinant protein expression in mammalian cells : the role of mRNA level and stability

Wulhfard, Sarah · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transient recombinant protein expression in mammalian cells : the role of mRNA level and stability

Authors: Wulhfard, Sarah

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/36998

Thesis Estudio transcriptómico y proteómico de células CHO productoras de glicoproteínas recombinantes hipotermia moderada

Bedoya López, Andrea · 2021 · Universidad Nacional Autónoma de México (UNAM) · DOI

Full title: Estudio transcriptómico y proteómico de células CHO productoras de glicoproteínas recombinantes hipotermia moderada

Authors: Bedoya López, Andrea

Year: 2021

Venue: Universidad Nacional Autónoma de México (UNAM)

DOI: https://hdl.handle.net/20.500.14330/TES01000755371

Thesis Small-molecule control of antibody N-glycosylation in engineered mammalian cells

Chang, Michelle; Gaidukov, Leonid; Jung, Giyoung et al. · 2020 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Small-molecule control of antibody N-glycosylation in engineered mammalian cells

Authors: Chang, Michelle; Gaidukov, Leonid; Jung, Giyoung; Tseng, Wen Allen; Scarcelli, John J.; Cornell, Richard; Marshall, Jeffrey K.; Lyles, Jonathan L; Sakorafas, Paul; Chu, An-Hsiang Adam; Cote, Kaffa; Tzvetkova, Boriana; Dolatshahi, Sepideh; Sumit, Madhuresh; Mulukutla, Bhanu Chandra; Lauffenburger, Douglas A; Figueroa, Bruno; Summers, Nevin M; Lu, Timothy K; Weiss, Ron

Year: 2020

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/125977

Thesis Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

Sumit, Madhuresh; Dolatshahi, Sepideh; Chu, An-Hsiang Adam et al. · 2020 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

Authors: Sumit, Madhuresh; Dolatshahi, Sepideh; Chu, An-Hsiang Adam; Cote, Kaffa; Scarcelli, John J.; Marshall, Jeffrey K.; Cornell, Richard J.; Weiss, Ron; Lauffenburger, Douglas A.; Mulukutla, Bhanu Chandra; Figueroa, Bruno

Year: 2020

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/125974

Thesis XBP1s Links the Unfolded Protein Response to the Molecular Architecture of Mature N-Glycans

Antonopoulos, Aristotelis; Haslam, Stuart M.; Dell, Anne et al. · 2017 · Massachusetts Institute of Technology (MIT) · DOI

Full title: XBP1s Links the Unfolded Protein Response to the Molecular Architecture of Mature N-Glycans

Authors: Antonopoulos, Aristotelis; Haslam, Stuart M.; Dell, Anne; Dewal, Mahender; DiChiara, Andrew Stephen; Taylor, Rebecca J.; Harmon, Chyleigh J.; Shoulders, Matthew D.

Year: 2017

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/106600

Thesis Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe et al. · 2016 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

Authors: López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe; Carrillo-Cocom, Leydi Maribel; Rocha-Pizaña, María del Refugio; Alvarez, Mario Moises

Year: 2016

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/105504

Thesis CIRP Expression on Growth and Productivity of CHO Cells

Tan, Hong-Kiat; Yap, Miranda G.S.; Wang, Daniel I.C. · 2005 · Massachusetts Institute of Technology (MIT) · DOI

Full title: CIRP Expression on Growth and Productivity of CHO Cells

Authors: Tan, Hong-Kiat; Yap, Miranda G.S.; Wang, Daniel I.C.

Year: 2005

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/30382

Thesis The Effect of Culture Temperature on Recombinant IFN-γ Production and Quality

Fox, Steven R.; Yap, Miranda G.S.; Wang, Daniel I.C. · 2003 · Massachusetts Institute of Technology (MIT) · DOI

Full title: The Effect of Culture Temperature on Recombinant IFN-γ Production and Quality

Authors: Fox, Steven R.; Yap, Miranda G.S.; Wang, Daniel I.C.

Year: 2003

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/3928

Thesis Reduced Temperature Production of Recombinant Proteins to Increase Productivity in Mammalian Cell Culture

Fox, Steven R.; Wang, Daniel I.C.; Yap, Miranda G.S. · 2003 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Reduced Temperature Production of Recombinant Proteins to Increase Productivity in Mammalian Cell Culture

Authors: Fox, Steven R.; Wang, Daniel I.C.; Yap, Miranda G.S.

Year: 2003

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/3946

Thesis Engineering Mammalian Cells for Improved Recombinant Protein Production

Wong, Niki S.C.; Tan, Hong-Kiat; Wang, Daniel I.C. et al. · 2003 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Engineering Mammalian Cells for Improved Recombinant Protein Production

Authors: Wong, Niki S.C.; Tan, Hong-Kiat; Wang, Daniel I.C.; Yap, Miranda G.S.

Year: 2003

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/3781

Thesis Active Hypothermic Growth: A Novel Means For Increasing Total Interferon-γ Production by Chinese Hamster Ovary Cells

Stephen R., Fox; Yap, Mei Xia; Yap, Miranda G.S. et al. · 2005 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Active Hypothermic Growth: A Novel Means For Increasing Total Interferon-γ Production by Chinese Hamster Ovary Cells

Authors: Stephen R., Fox; Yap, Mei Xia; Yap, Miranda G.S.; Wang, Daniel I.C.

Year: 2005

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/30379

Thesis Cell-line Engineering for Low-temperature Growth

Tan, Hong-Kiat; Yap, Miranda G.S.; Wang, Daniel I.C. · 2003 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Cell-line Engineering for Low-temperature Growth

Authors: Tan, Hong-Kiat; Yap, Miranda G.S.; Wang, Daniel I.C.

Year: 2003

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/3926

Thesis Directed evolution of Chinese Hamster Ovary cells

Syddall, Katie Louise · 2016 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Directed evolution of Chinese Hamster Ovary cells

Authors: Syddall, Katie Louise

Year: 2016

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/13836/1/Thesis_FINAL_Post_Corrections_AUG16_KatieSyddall.pdf

Thesis Influence of cell-line and process conditions on the glycosylation of recombinant proteins

Nahrgang, Stefan · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Influence of cell-line and process conditions on the glycosylation of recombinant proteins

Authors: Nahrgang, Stefan

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/211632

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Metadata only

Paper Enhanced interferon-beta production by CHO cells through elevated osmolality and reduced culture temperature.

Han, Young Kue; Koo, Tai Young; Lee, Gyun Min · 2009 · Biotechnology progress · DOI

Full title: Enhanced interferon-beta production by CHO cells through elevated osmolality and reduced culture temperature.

Authors: Han, Young Kue; Koo, Tai Young; Lee, Gyun Min

Year: 2009

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.234

Paper A strategy for clone selection under different production conditions.

Legmann, Rachel; Benoit, Brian; Fedechko, Ronald W et al. · 2011 · Biotechnology progress · DOI

Full title: A strategy for clone selection under different production conditions.

Authors: Legmann, Rachel; Benoit, Brian; Fedechko, Ronald W; Deppeler, Cynthia L; Srinivasan, Sriram; Robins, Russell H; McCormick, Ellen L; Ferrick, David A; Rodgers, Seth T; Russo, A Peter

Year: 2011

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.577

Paper Temperature Down-Shift Modifies Expression of UPR-/ERAD-Related Genes and Enhances Production of a Chimeric Fusion Protein in CHO Cells.

Torres, Mauro; Akhtar, Samia; McKenzie, Edward A et al. · 2021 · Biotechnology journal · DOI

Full title: Temperature Down-Shift Modifies Expression of UPR-/ERAD-Related Genes and Enhances Production of a Chimeric Fusion Protein in CHO Cells.

Authors: Torres, Mauro; Akhtar, Samia; McKenzie, Edward A; Dickson, Alan J

Year: 2021

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202000081

Paper Bioinformatic Identification of Chinese Hamster Ovary (CHO) Cold-Shock Genes and Biological Evidence of their Cold-Inducible Promoters.

Nguyen, Ly Ngoc; Novak, Neža; Baumann, Martina et al. · 2020 · Biotechnology journal · DOI

Full title: Bioinformatic Identification of Chinese Hamster Ovary (CHO) Cold-Shock Genes and Biological Evidence of their Cold-Inducible Promoters.

Authors: Nguyen, Ly Ngoc; Novak, Neža; Baumann, Martina; Koehn, Jadranka; Borth, Nicole

Year: 2020

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201900359

Paper A Comparative Transcriptomics Workflow for Analyzing Microarray Data From CHO Cell Cultures.

Chen, Chun; Le, Huong; Follstad, Brian et al. · 2018 · Biotechnology journal · DOI

Full title: A Comparative Transcriptomics Workflow for Analyzing Microarray Data From CHO Cell Cultures.

Authors: Chen, Chun; Le, Huong; Follstad, Brian; Goudar, Chetan T

Year: 2018

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201700228

Paper The CAG promoter maintains high-level transgene expression in HEK293 cells.

Dou, Yuanyuan; Lin, Yan; Wang, Tian-Yun et al. · 2021 · FEBS open bio · DOI

Full title: The CAG promoter maintains high-level transgene expression in HEK293 cells.

Authors: Dou, Yuanyuan; Lin, Yan; Wang, Tian-Yun; Wang, Xiao-Yin; Jia, Yan-Long; Zhao, Chun-Peng

Year: 2021

Venue: FEBS open bio

DOI: https://doi.org/10.1002/2211-5463.13029

Paper Effect of culture temperature on erythropoietin production and glycosylation in a perfusion culture of recombinant CHO cells.

Ahn, Woo Suk; Jeon, Jae-Jin; Jeong, Yeong-Ran et al. · 2008 · Biotechnology and bioengineering · DOI

Full title: Effect of culture temperature on erythropoietin production and glycosylation in a perfusion culture of recombinant CHO cells.

Authors: Ahn, Woo Suk; Jeon, Jae-Jin; Jeong, Yeong-Ran; Lee, Seung Joo; Yoon, Sung Kwan

Year: 2008

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.22006

Paper FMRFamide-like peptides encoded on the flp-18 precursor gene activate two isoforms of the orphan Caenorhabditis elegans G-protein-coupled receptor Y58G8A.4 heterologously expressed in mammalian cells.

Kubiak, Teresa M; Larsen, Martha J; Bowman, Jerry W et al. · 2008 · Biopolymers · DOI

Full title: FMRFamide-like peptides encoded on the flp-18 precursor gene activate two isoforms of the orphan Caenorhabditis elegans G-protein-coupled receptor Y58G8A.4 heterologously expressed in mammalian cells.

Authors: Kubiak, Teresa M; Larsen, Martha J; Bowman, Jerry W; Geary, Timothy G; Lowery, David E

Year: 2008

Venue: Biopolymers

DOI: https://doi.org/10.1002/bip.20850

Paper Performance of small-scale CHO perfusion cultures using an acoustic cell filtration device for cell retention: characterization of separation efficiency and impact of perfusion on product quality.

Ryll, T; Dutina, G; Reyes, A et al. · 2000 · Biotechnology and bioengineering · DOI

Full title: Performance of small-scale CHO perfusion cultures using an acoustic cell filtration device for cell retention: characterization of separation efficiency and impact of perfusion on product quality.

Authors: Ryll, T; Dutina, G; Reyes, A; Gunson, J; Krummen, L; Etcheverry, T

Year: 2000

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/1097-0290(20000820)69:4<440::aid-bit10>3.0.co;2-0

Paper Process parameter shifting: Part II. Biphasic cultivation-A tool for enhancing the volumetric productivity of batch processes using Epo-Fc expressing CHO cells.

Trummer, Evelyn; Fauland, Katharina; Seidinger, Silke et al. · 2006 · Biotechnology and bioengineering · DOI

Full title: Process parameter shifting: Part II. Biphasic cultivation-A tool for enhancing the volumetric productivity of batch processes using Epo-Fc expressing CHO cells.

Authors: Trummer, Evelyn; Fauland, Katharina; Seidinger, Silke; Schriebl, Kornelia; Lattenmayer, Christine; Kunert, Renate; Vorauer-Uhl, Karola; Weik, Robert; Borth, Nicole; Katinger, Hermann; Müller, Dethardt

Year: 2006

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.20958

Paper Temperature-sensitive miR-483 is a conserved regulator of recombinant protein and viral vector production in mammalian cells.

Emmerling, Verena V; Fischer, Simon; Stiefel, Fabian et al. · 2016 · Biotechnology and bioengineering · DOI

Full title: Temperature-sensitive miR-483 is a conserved regulator of recombinant protein and viral vector production in mammalian cells.

Authors: Emmerling, Verena V; Fischer, Simon; Stiefel, Fabian; Holzmann, Karlheinz; Handrick, René; Hesse, Friedemann; Hörer, Markus; Kochanek, Stefan; Otte, Kerstin

Year: 2016

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.25853

Paper Impact of cell culture process changes on endogenous retrovirus expression.

Brorson, Kurt; De Wit, Christina; Hamilton, Elizabeth et al. · 2002 · Biotechnology and bioengineering · DOI

Full title: Impact of cell culture process changes on endogenous retrovirus expression.

Authors: Brorson, Kurt; De Wit, Christina; Hamilton, Elizabeth; Mustafa, Mehnaz; Swann, Patrick G; Kiss, Robert; Taticek, Ron; Polastri, Gian; Stein, Kathryn E; Xu, Yuan

Year: 2002

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.10366

Paper Maximizing interferon-gamma production by Chinese hamster ovary cells through temperature shift optimization: experimental and modeling.

Fox, Stephen R; Patel, Upasana A; Yap, Miranda G S et al. · 2004 · Biotechnology and bioengineering · DOI

Full title: Maximizing interferon-gamma production by Chinese hamster ovary cells through temperature shift optimization: experimental and modeling.

Authors: Fox, Stephen R; Patel, Upasana A; Yap, Miranda G S; Wang, Daniel I C

Year: 2004

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.10861

Paper Comparative transcriptome analysis to unveil genes affecting recombinant protein productivity in mammalian cells.

Yee, Joon Chong; Gerdtzen, Ziomara P; Hu, Wei-Shou · 2009 · Biotechnology and bioengineering · DOI

Full title: Comparative transcriptome analysis to unveil genes affecting recombinant protein productivity in mammalian cells.

Authors: Yee, Joon Chong; Gerdtzen, Ziomara P; Hu, Wei-Shou

Year: 2009

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.22039

Paper Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo-Fc expressing CHO cells cultivated in controlled batch bioreactors.

Trummer, Evelyn; Fauland, Katharina; Seidinger, Silke et al. · 2006 · Biotechnology and bioengineering · DOI

Full title: Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo-Fc expressing CHO cells cultivated in controlled batch bioreactors.

Year: 2006

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.21013

Paper How does mild hypothermia affect monoclonal antibody glycosylation?

Sou, Si Nga; Sellick, Christopher; Lee, Ken et al. · 2015 · Biotechnology and bioengineering · DOI

Full title: How does mild hypothermia affect monoclonal antibody glycosylation?

Authors: Sou, Si Nga; Sellick, Christopher; Lee, Ken; Mason, Alison; Kyriakopoulos, Sarantos; Polizzi, Karen M; Kontoravdi, Cleo

Year: 2015

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.25524

Paper Effects of culture conditions on N-glycolylneuraminic acid (Neu5Gc) content of a recombinant fusion protein produced in CHO cells.

Borys, Michael C; Dalal, Nimish G; Abu-Absi, Nicholas R et al. · 2010 · Biotechnology and bioengineering · DOI

Full title: Effects of culture conditions on N-glycolylneuraminic acid (Neu5Gc) content of a recombinant fusion protein produced in CHO cells.

Authors: Borys, Michael C; Dalal, Nimish G; Abu-Absi, Nicholas R; Khattak, Sarwat F; Jing, Ying; Xing, Zizhuo; Li, Zheng Jian

Year: 2010

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.22644

Paper Model-based investigation of intracellular processes determining antibody Fc-glycosylation under mild hypothermia.

Sou, Si Nga; Jedrzejewski, Philip M; Lee, Ken et al. · 2017 · Biotechnology and bioengineering · DOI

Full title: Model-based investigation of intracellular processes determining antibody Fc-glycosylation under mild hypothermia.

Authors: Sou, Si Nga; Jedrzejewski, Philip M; Lee, Ken; Sellick, Christopher; Polizzi, Karen M; Kontoravdi, Cleo

Year: 2017

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.26225

Paper Cascading effect in bioprocessing-The impact of mild hypothermia on CHO cell behavior and host cell protein composition.

Goey, Cher H; Tsang, Joshua M H; Bell, David et al. · 2017 · Biotechnology and bioengineering · DOI

Full title: Cascading effect in bioprocessing-The impact of mild hypothermia on CHO cell behavior and host cell protein composition.

Authors: Goey, Cher H; Tsang, Joshua M H; Bell, David; Kontoravdi, Cleo

Year: 2017

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.26437

Paper Integrated cell and process engineering for improved transient production of a "difficult-to-express" fusion protein by CHO cells.

Johari, Yusuf B; Estes, Scott D; Alves, Christina S et al. · 2015 · Biotechnology and bioengineering · DOI

Full title: Integrated cell and process engineering for improved transient production of a "difficult-to-express" fusion protein by CHO cells.

Authors: Johari, Yusuf B; Estes, Scott D; Alves, Christina S; Sinacore, Marty S; James, David C

Year: 2015

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.25687

Paper Accelerating perfusion process optimization by scanning non-steady-state responses.

Angepat, Sumitra; Gorenflo, Volker M; Piret, James M · 2005 · Biotechnology and bioengineering · DOI

Full title: Accelerating perfusion process optimization by scanning non-steady-state responses.

Authors: Angepat, Sumitra; Gorenflo, Volker M; Piret, James M

Year: 2005

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.20635

Paper The effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells.

Nam, Jong Hyun; Zhang, Fuming; Ermonval, Myriam et al. · 2008 · Biotechnology and bioengineering · DOI

Full title: The effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells.

Authors: Nam, Jong Hyun; Zhang, Fuming; Ermonval, Myriam; Linhardt, Robert J; Sharfstein, Susan T

Year: 2008

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.21853

Paper Exploring cellular behavior under transient gene expression and its impact on mAb productivity and Fc-glycosylation.

Sou, Si N; Lee, Ken; Nayyar, Kalpana et al. · 2018 · Biotechnology and bioengineering · DOI

Full title: Exploring cellular behavior under transient gene expression and its impact on mAb productivity and Fc-glycosylation.

Authors: Sou, Si N; Lee, Ken; Nayyar, Kalpana; Polizzi, Karen M; Sellick, Christopher; Kontoravdi, Cleo

Year: 2018

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.26456

Paper Culture temperature modulates half antibody and aggregate formation in a Chinese hamster ovary cell line expressing a bispecific antibody.

Gomez, Natalia; Wieczorek, Agatha; Lu, Fang et al. · 2018 · Biotechnology and bioengineering · DOI

Full title: Culture temperature modulates half antibody and aggregate formation in a Chinese hamster ovary cell line expressing a bispecific antibody.

Authors: Gomez, Natalia; Wieczorek, Agatha; Lu, Fang; Bruno, Richele; Diaz, Luis; Agrawal, Neeraj J; Daris, Kristi

Year: 2018

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.26803

Paper Use of an anti-apoptotic CHO cell line for transient gene expression.

Macaraeg, Nichole F; Reilly, Dorothea E; Wong, Athena W · 2013 · Biotechnology progress · DOI

Full title: Use of an anti-apoptotic CHO cell line for transient gene expression.

Authors: Macaraeg, Nichole F; Reilly, Dorothea E; Wong, Athena W

Year: 2013

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.1763

Paper Reduction of IL-2 fragmentation during manufacturing of a novel immunocytokine by DoE process optimization.

Schneider, Alina; Gorr, Ingo H; Larraillet, Vincent et al. · 2019 · Biotechnology and bioengineering · DOI

Full title: Reduction of IL-2 fragmentation during manufacturing of a novel immunocytokine by DoE process optimization.

Authors: Schneider, Alina; Gorr, Ingo H; Larraillet, Vincent; Frensing, Timo; Popp, Oliver

Year: 2019

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.27090

Paper Production and characterization of active recombinant human factor II with consistent sialylation.

Lee, Jeong H; Reier, Jason; Heffner, Kelley M et al. · 2017 · Biotechnology and bioengineering · DOI

Full title: Production and characterization of active recombinant human factor II with consistent sialylation.

Authors: Lee, Jeong H; Reier, Jason; Heffner, Kelley M; Barton, Christopher; Spencer, David; Schmelzer, Albert E; Venkat, Raghavan

Year: 2017

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.26317

Paper Identification of process conditions influencing protein aggregation in Chinese hamster ovary cell culture.

Paul, Albert J; Handrick, René; Ebert, Sybille et al. · 2018 · Biotechnology and bioengineering · DOI

Full title: Identification of process conditions influencing protein aggregation in Chinese hamster ovary cell culture.

Authors: Paul, Albert J; Handrick, René; Ebert, Sybille; Hesse, Friedemann

Year: 2018

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.26534

Paper Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to improve biosimilar product quality.

Brühlmann, David; Sokolov, Michael; Butté, Alessandro et al. · 2017 · Biotechnology and bioengineering · DOI

Full title: Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to improve biosimilar product quality.

Authors: Brühlmann, David; Sokolov, Michael; Butté, Alessandro; Sauer, Markus; Hemberger, Jürgen; Souquet, Jonathan; Broly, Hervé; Jordan, Martin

Year: 2017

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.26269

Paper Differential response in downstream processing of CHO cells grown under mild hypothermic conditions.

Tait, Andrew S; Tarrant, Richard D R; Velez-Suberbie, M Lourdes et al. · 2013 · Biotechnology progress · DOI

Full title: Differential response in downstream processing of CHO cells grown under mild hypothermic conditions.

Authors: Tait, Andrew S; Tarrant, Richard D R; Velez-Suberbie, M Lourdes; Spencer, Daniel I R; Bracewell, Daniel G

Year: 2013

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.1726

Paper Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothermic Conditions.

Ryan, David; Sideri, Christiana-Kondylo; Henry, Michael et al. · 2026 · Biotechnology and bioengineering · DOI

Full title: Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothermic Conditions.

Authors: Ryan, David; Sideri, Christiana-Kondylo; Henry, Michael; Karuppuchamy, Selvaprakash; Efeoglu, Esen; Meleady, Paula

Year: 2026

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.70081

Paper Perfusion process combining low temperature and valeric acid for enhanced recombinant factor VIII production.

Coronel, Juliana; Heinrich, Christoph; Klausing, Sandra et al. · 2020 · Biotechnology progress · DOI

Full title: Perfusion process combining low temperature and valeric acid for enhanced recombinant factor VIII production.

Authors: Coronel, Juliana; Heinrich, Christoph; Klausing, Sandra; Noll, Thomas; Figueredo-Cardero, Alvio; Castilho, Leda R

Year: 2020

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2915

Paper Kinetic modeling as a tool to understand the influence of cell culture process parameters on the glycation of monoclonal antibody biotherapeutics.

Agarwal, Nitin; Mason, Alison; Pradhan, Rahul et al. · 2019 · Biotechnology progress · DOI

Full title: Kinetic modeling as a tool to understand the influence of cell culture process parameters on the glycation of monoclonal antibody biotherapeutics.

Authors: Agarwal, Nitin; Mason, Alison; Pradhan, Rahul; Kemper, Jan; Bosley, Allen; Serfiotis-Mitsa, Dimitra; Wang, Jihong; Lindo, Viv; Ahuja, Sanjeev; Hatton, Diane; Savery, James; Miro-Quesada, Guillermo

Year: 2019

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2865

Paper Exploring the linkage between cell culture process parameters and downstream processing utilizing a plackett-burman design for a model monoclonal antibody.

Agarabi, Cyrus D; Chavez, Brittany K; Lute, Scott C et al. · 2017 · Biotechnology progress · DOI

Full title: Exploring the linkage between cell culture process parameters and downstream processing utilizing a plackett-burman design for a model monoclonal antibody.

Authors: Agarabi, Cyrus D; Chavez, Brittany K; Lute, Scott C; Read, Erik K; Rogstad, Sarah; Awotwe-Otoo, David; Brown, Matthew R; Boyne, Michael T; Brorson, Kurt A

Year: 2017

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2402

Paper Combining mechanistic and data-driven approaches to gain process knowledge on the control of the metabolic shift to lactate uptake in a fed-batch CHO process.

Zalai, Dénes; Koczka, Krisztina; Párta, László et al. · 2015 · Biotechnology progress · DOI

Full title: Combining mechanistic and data-driven approaches to gain process knowledge on the control of the metabolic shift to lactate uptake in a fed-batch CHO process.

Authors: Zalai, Dénes; Koczka, Krisztina; Párta, László; Wechselberger, Patrick; Klein, Tobias; Herwig, Christoph

Year: 2015

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2179

Paper Subphysiological temperature induces pervasive alternative splicing in Chinese hamster ovary cells.

Tzani, Ioanna; Monger, Craig; Motheramgari, Krishna et al. · 2020 · Biotechnology and bioengineering · DOI

Full title: Subphysiological temperature induces pervasive alternative splicing in Chinese hamster ovary cells.

Authors: Tzani, Ioanna; Monger, Craig; Motheramgari, Krishna; Gallagher, Clair; Hagan, Ryan; Kelly, Paul; Costello, Alan; Meiller, Justine; Floris, Patrick; Zhang, Lin; Clynes, Martin; Bones, Jonathan; Barron, Niall; Clarke, Colin

Year: 2020

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.27365

Paper Effective temperature shift strategy development and scale confirmation for simultaneous optimization of protein productivity and quality in Chinese hamster ovary cells.

McHugh, Kyle P; Xu, Jianlin; Aron, Kathryn L et al. · 2020 · Biotechnology progress · DOI

Full title: Effective temperature shift strategy development and scale confirmation for simultaneous optimization of protein productivity and quality in Chinese hamster ovary cells.

Authors: McHugh, Kyle P; Xu, Jianlin; Aron, Kathryn L; Borys, Michael C; Li, Zheng Jian

Year: 2020

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2959

Paper Exploring the capabilities of fluorometric online monitoring on chinese hamster ovary cell cultivations producing a monoclonal antibody.

Schwab, Karen; Amann, Thomas; Schmid, Jakob et al. · 2016 · Biotechnology progress · DOI

Full title: Exploring the capabilities of fluorometric online monitoring on chinese hamster ovary cell cultivations producing a monoclonal antibody.

Authors: Schwab, Karen; Amann, Thomas; Schmid, Jakob; Handrick, René; Hesse, Friedemann

Year: 2016

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2326

Paper Changes in intracellular ATP-content of CHO cells as response to hyperosmolality.

Pfizenmaier, Jennifer; Matuszczyk, Jens-Christoph; Takors, Ralf · 2015 · Biotechnology progress · DOI

Full title: Changes in intracellular ATP-content of CHO cells as response to hyperosmolality.

Authors: Pfizenmaier, Jennifer; Matuszczyk, Jens-Christoph; Takors, Ralf

Year: 2015

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2143

Paper High yields of monomeric recombinant beta-interferon from macroporous microcarrier cultures under hypothermic conditions.

Tharmalingam, Tharmala; Sunley, Kevin; Butler, Michael · 2008 · Biotechnology progress · DOI

Full title: High yields of monomeric recombinant beta-interferon from macroporous microcarrier cultures under hypothermic conditions.

Authors: Tharmalingam, Tharmala; Sunley, Kevin; Butler, Michael

Year: 2008

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.8

Paper Innovating cell culture process development with deep learning-powered robotic experimentation using the first Industrial Smart Lab Framework.

Xu, Shuting; Huang, Yanting; Shen, Xin et al. · 2025 · Biotechnology progress · DOI

Full title: Innovating cell culture process development with deep learning-powered robotic experimentation using the first Industrial Smart Lab Framework.

Authors: Xu, Shuting; Huang, Yanting; Shen, Xin; Mao, Rongjia; Song, Yiming; Ye, Wanying; Wang, Lijun; Tong, Xiaoxiao; Cao, Yun; Sun, Ruiqiang; Zhou, Hang; Zhou, Weichang

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.70051

Paper CHO cells adapted to hypothermic growth produce high yields of recombinant beta-interferon.

Sunley, Kevin; Tharmalingam, Tharmala; Butler, Michael · 2008 · Biotechnology progress · DOI

Full title: CHO cells adapted to hypothermic growth produce high yields of recombinant beta-interferon.

Authors: Sunley, Kevin; Tharmalingam, Tharmala; Butler, Michael

Year: 2008

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.9

Paper Influence of low temperature on productivity, proteome and protein phosphorylation of CHO cells.

Kaufmann, H; Mazur, X; Fussenegger, M et al. · 1999 · Biotechnology and bioengineering · DOI

Full title: Influence of low temperature on productivity, proteome and protein phosphorylation of CHO cells.

Authors: Kaufmann, H; Mazur, X; Fussenegger, M; Bailey, J E

Year: 1999

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/(sici)1097-0290(19990605)63:5<573::aid-bit7>3.0.co;2-y

Paper Differential effects of bioreactor process variables and purification on the human recombinant lysosomal enzyme β-glucuronidase produced from Chinese hamster ovary cells.

Parhiz, Hamideh; Ketcham, Stephanie A; Zou, Guozhang et al. · 2019 · Applied microbiology and biotechnology · DOI

Full title: Differential effects of bioreactor process variables and purification on the human recombinant lysosomal enzyme β-glucuronidase produced from Chinese hamster ovary cells.

Authors: Parhiz, Hamideh; Ketcham, Stephanie A; Zou, Guozhang; Ghosh, Bidesh; Fratz-Berilla, Erica J; Ashraf, Muhammad; Ju, Tongzhong; Madhavarao, Chikkathur N

Year: 2019

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-019-09889-7

Paper Synergistic promotion of transient transgene expression in CHO cells by PDI/XBP-1s co-transfection and mild hypothermia.

Zhang, Xi; Wang, Yaokun; Yi, Dandan et al. · 2024 · Bioprocess and biosystems engineering · DOI

Full title: Synergistic promotion of transient transgene expression in CHO cells by PDI/XBP-1s co-transfection and mild hypothermia.

Authors: Zhang, Xi; Wang, Yaokun; Yi, Dandan; Zhang, Chi; Ning, Binhuan; Fu, Yushun; Jia, Yanlong; Wang, Tianyun; Wang, Xiaoyin

Year: 2024

Venue: Bioprocess and biosystems engineering

DOI: https://doi.org/10.1007/s00449-024-02987-5

Paper Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells.

Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia et al. · 2012 · Biotechnology letters · DOI

Full title: Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells.

Authors: Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia; Hacker, David L; Wurm, Florian M

Year: 2012

Venue: Biotechnology letters

DOI: https://doi.org/10.1007/s10529-011-0809-z

Paper Effect of culture temperature on follicle-stimulating hormone production by Chinese hamster ovary cells in a perfusion bioreactor.

Yoon, Sung Kwan; Ahn, Yong-Ho; Jeong, Myeong Hyeon · 2007 · Applied microbiology and biotechnology · DOI

Full title: Effect of culture temperature on follicle-stimulating hormone production by Chinese hamster ovary cells in a perfusion bioreactor.

Authors: Yoon, Sung Kwan; Ahn, Yong-Ho; Jeong, Myeong Hyeon

Year: 2007

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-007-0985-x

Paper Reduction of charge variants by CHO cell culture process optimization.

Weng, Zhibing; Jin, Jian; Shao, ChunHua et al. · 2020 · Cytotechnology · DOI

Full title: Reduction of charge variants by CHO cell culture process optimization.

Authors: Weng, Zhibing; Jin, Jian; Shao, ChunHua; Li, Huazhong

Year: 2020

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-020-00375-x

Paper pH Condition in temperature shift cultivation enhances cell longevity and specific hMab productivity in CHO culture.

Oguchi, Satoshi; Saito, Hiroyuki; Tsukahara, Masayoshi et al. · 2006 · Cytotechnology · DOI

Full title: pH Condition in temperature shift cultivation enhances cell longevity and specific hMab productivity in CHO culture.

Authors: Oguchi, Satoshi; Saito, Hiroyuki; Tsukahara, Masayoshi; Tsumura, Haruhiko

Year: 2006

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-007-9059-2

Paper Controlled growth of Chinese hamster ovary cells and high expression of antibody-IL-2 fusion proteins by temperature manipulation.

Shi, Ming; Xie, Zhigang; Yu, Ming et al. · 2005 · Biotechnology letters · DOI

Full title: Controlled growth of Chinese hamster ovary cells and high expression of antibody-IL-2 fusion proteins by temperature manipulation.

Authors: Shi, Ming; Xie, Zhigang; Yu, Ming; Shen, Beifen; Guo, Ning

Year: 2005

Venue: Biotechnology letters

DOI: https://doi.org/10.1007/s10529-005-3897-9

Paper The effects of microcarrier culture on recombinant CHO cells under biphasic hypothermic culture conditions.

Nam, Jong Hyun; Ermonval, Myriam; Sharfstein, Susan T · 2009 · Cytotechnology · DOI

Full title: The effects of microcarrier culture on recombinant CHO cells under biphasic hypothermic culture conditions.

Authors: Nam, Jong Hyun; Ermonval, Myriam; Sharfstein, Susan T

Year: 2009

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-009-9196-x

Paper Comparative study of commercial media to improve GMP manufacturing of recombinant human interferon β-1a by CHO cells in perfusion bioreactor.

Sedighikamal, Hossein; Karimi Mostofi, Reza; Sattarzadeh, Alireza et al. · 2022 · Cytotechnology · DOI

Full title: Comparative study of commercial media to improve GMP manufacturing of recombinant human interferon β-1a by CHO cells in perfusion bioreactor.

Authors: Sedighikamal, Hossein; Karimi Mostofi, Reza; Sattarzadeh, Alireza; Shahbazi, Mansour; Aghazadeh, Hossein

Year: 2022

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-022-00554-y

Paper Comparison of different transient gene expression systems for the production of a new humanized anti-HER2 monoclonal antibody (Hersintuzumab).

Roshani, Ali; Mohammadi, Mehdi; Bahadori, Tannaz et al. · 2023 · Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · DOI

Full title: Comparison of different transient gene expression systems for the production of a new humanized anti-HER2 monoclonal antibody (Hersintuzumab).

Authors: Roshani, Ali; Mohammadi, Mehdi; Bahadori, Tannaz; Ahmadi Zare, Hengameh; Judaki, Mohammad Ali; Mobini, Maryam; Golsaz-Shirazi, Forough; Jeddi-Tehrani, Mahmood; Amiri, Mohammad Mehdi; Shokri, Fazel

Year: 2023

Venue: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences

DOI: https://doi.org/10.1007/s40199-023-00477-9

Paper EGCG improves recombinant protein productivity in Chinese hamster ovary cell cultures via cell proliferation control.

Yamano, Noriko; Omasa, Takeshi · 2018 · Cytotechnology · DOI

Full title: EGCG improves recombinant protein productivity in Chinese hamster ovary cell cultures via cell proliferation control.

Authors: Yamano, Noriko; Omasa, Takeshi

Year: 2018

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-018-0243-3

Paper Combination of temperature shift and hydrolysate addition regulates anti-IgE monoclonal antibody charge heterogeneity in Chinese hamster ovary cell fed-batch culture.

Zheng, Chen; Zhuang, Chao; Qin, Jinyan et al. · 2018 · Cytotechnology · DOI

Full title: Combination of temperature shift and hydrolysate addition regulates anti-IgE monoclonal antibody charge heterogeneity in Chinese hamster ovary cell fed-batch culture.

Authors: Zheng, Chen; Zhuang, Chao; Qin, Jinyan; Chen, Yantian; Fu, Qiang; Qian, Hui; Wu, Tong; Wang, Yanchao; Wu, Xiang; Qi, Nianmin

Year: 2018

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-018-0192-x

Paper Enhanced CHO cell-based transient gene expression with the epi-CHO expression system.

Codamo, Joe; Munro, Trent P; Hughes, Benjamin S et al. · 2011 · Molecular biotechnology · DOI

Full title: Enhanced CHO cell-based transient gene expression with the epi-CHO expression system.

Authors: Codamo, Joe; Munro, Trent P; Hughes, Benjamin S; Song, Michael; Gray, Peter P

Year: 2011

Venue: Molecular biotechnology

DOI: https://doi.org/10.1007/s12033-010-9351-9

Paper Applications of proteomic methods for CHO host cell protein characterization in biopharmaceutical manufacturing.

Valente, Kristin N; Levy, Nicholas E; Lee, Kelvin H et al. · 2018 · Current opinion in biotechnology · DOI

Full title: Applications of proteomic methods for CHO host cell protein characterization in biopharmaceutical manufacturing.

Authors: Valente, Kristin N; Levy, Nicholas E; Lee, Kelvin H; Lenhoff, Abraham M

Year: 2018

Venue: Current opinion in biotechnology

DOI: https://doi.org/10.1016/j.copbio.2018.01.004

Paper Transcriptome analysis of a CHO cell line expressing a recombinant therapeutic protein treated with inducers of protein expression.

Fomina-Yadlin, Dina; Mujacic, Mirna; Maggiora, Kathy et al. · 2015 · Journal of biotechnology · DOI

Full title: Transcriptome analysis of a CHO cell line expressing a recombinant therapeutic protein treated with inducers of protein expression.

Authors: Fomina-Yadlin, Dina; Mujacic, Mirna; Maggiora, Kathy; Quesnell, Garrett; Saleem, Ramsey; McGrew, Jeffrey T

Year: 2015

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2015.08.025

Paper Model-based optimization of temperature and pH shift to increase volumetric productivity of a Chinese hamster ovary fed-batch process.

Paul, Katrin; Rajamanickam, Vignesh; Herwig, Christoph · 2019 · Journal of bioscience and bioengineering · DOI

Full title: Model-based optimization of temperature and pH shift to increase volumetric productivity of a Chinese hamster ovary fed-batch process.

Authors: Paul, Katrin; Rajamanickam, Vignesh; Herwig, Christoph

Year: 2019

Venue: Journal of bioscience and bioengineering

DOI: https://doi.org/10.1016/j.jbiosc.2019.06.004

Paper Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7.

Barron, N; Kumar, N; Sanchez, N et al. · 2011 · Journal of biotechnology · DOI

Full title: Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7.

Authors: Barron, N; Kumar, N; Sanchez, N; Doolan, P; Clarke, C; Meleady, P; O'Sullivan, F; Clynes, M

Year: 2011

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2010.12.005

Paper Initial identification of low temperature and culture stage induction of miRNA expression in suspension CHO-K1 cells.

Gammell, Patrick; Barron, Niall; Kumar, Niraj et al. · 2007 · Journal of biotechnology · DOI

Full title: Initial identification of low temperature and culture stage induction of miRNA expression in suspension CHO-K1 cells.

Authors: Gammell, Patrick; Barron, Niall; Kumar, Niraj; Clynes, Martin

Year: 2007

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2007.04.020

Paper Predicting cell-specific productivity from CHO gene expression.

Clarke, Colin; Doolan, Padraig; Barron, Niall et al. · 2011 · Journal of biotechnology · DOI

Full title: Predicting cell-specific productivity from CHO gene expression.

Authors: Clarke, Colin; Doolan, Padraig; Barron, Niall; Meleady, Paula; O'Sullivan, Finbarr; Gammell, Patrick; Melville, Mark; Leonard, Mark; Clynes, Martin

Year: 2011

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2010.11.016

Paper Biphasic cultivation strategy to avoid Epo-Fc aggregation and optimize protein expression.

Kaisermayer, Christian; Reinhart, David; Gili, Andreas et al. · 2016 · Journal of biotechnology · DOI

Full title: Biphasic cultivation strategy to avoid Epo-Fc aggregation and optimize protein expression.

Authors: Kaisermayer, Christian; Reinhart, David; Gili, Andreas; Chang, Martina; Aberg, Per-Mikael; Castan, Andreas; Kunert, Renate

Year: 2016

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2016.03.054

Paper miRNA profiling of high, low and non-producing CHO cells during biphasic fed-batch cultivation reveals process relevant targets for host cell engineering.

Stiefel, Fabian; Fischer, Simon; Sczyrba, Alexander et al. · 2016 · Journal of biotechnology · DOI

Full title: miRNA profiling of high, low and non-producing CHO cells during biphasic fed-batch cultivation reveals process relevant targets for host cell engineering.

Authors: Stiefel, Fabian; Fischer, Simon; Sczyrba, Alexander; Otte, Kerstin; Hesse, Friedemann

Year: 2016

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2016.03.028

Paper Dynamic model for CHO cell engineering.

Nolan, Ryan P; Lee, Kyongbum · 2012 · Journal of biotechnology · DOI

Full title: Dynamic model for CHO cell engineering.

Authors: Nolan, Ryan P; Lee, Kyongbum

Year: 2012

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2012.01.009

Paper Effect of temperature shift on levels of acidic charge variants in IgG monoclonal antibodies in Chinese hamster ovary cell culture.

Kishishita, Shohei; Nishikawa, Tomoko; Shinoda, Yasuharu et al. · 2015 · Journal of bioscience and bioengineering · DOI

Full title: Effect of temperature shift on levels of acidic charge variants in IgG monoclonal antibodies in Chinese hamster ovary cell culture.

Authors: Kishishita, Shohei; Nishikawa, Tomoko; Shinoda, Yasuharu; Nagashima, Hiroaki; Okamoto, Hiroshi; Takuma, Shinya; Aoyagi, Hideki

Year: 2015

Venue: Journal of bioscience and bioengineering

DOI: https://doi.org/10.1016/j.jbiosc.2014.10.028

Paper Very high cell density perfusion of CHO cells anchored in a non-woven matrix-based bioreactor.

Zhang, Ye; Stobbe, Per; Silvander, Christian Orrego et al. · 2015 · Journal of biotechnology · DOI

Full title: Very high cell density perfusion of CHO cells anchored in a non-woven matrix-based bioreactor.

Authors: Zhang, Ye; Stobbe, Per; Silvander, Christian Orrego; Chotteau, Véronique

Year: 2015

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2015.07.006

Paper Investigating the metabolic load of monoclonal antibody production conveyed to an inducible CHO cell line using a transfer-rate online monitoring system.

Reyes, Sebastian-Juan; Lemire, Lucas; Durocher, Yves et al. · 2025 · Journal of biotechnology · DOI

Full title: Investigating the metabolic load of monoclonal antibody production conveyed to an inducible CHO cell line using a transfer-rate online monitoring system.

Authors: Reyes, Sebastian-Juan; Lemire, Lucas; Durocher, Yves; Voyer, Robert; Henry, Olivier; Pham, Phuong Lan

Year: 2025

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2025.01.008

Paper Development of a 10 g/L process for a difficult-to-express multispecific antibody format using a holistic process development approach.

Peltret, Mégane; Vetsch, Patrick; Farvaque, Elodie et al. · 2024 · Journal of biotechnology · DOI

Full title: Development of a 10 g/L process for a difficult-to-express multispecific antibody format using a holistic process development approach.

Authors: Peltret, Mégane; Vetsch, Patrick; Farvaque, Elodie; Mette, Romain; Tsachaki, Maria; Duarte, Lionel; Duret, Anaïs; Vaxelaire, Emilie; Frank, Jana; Moritz, Benjamin; Aillerie, Céline; Giovannini, Roberto; Bertschinger, Martin

Year: 2024

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2024.04.017

Paper A novel dynamic flux balance analysis for modeling CHO cell fed-batch cultures with pH and temperature shifts.

Ghodba, Ali; Richelle, Anne; McCready, Chris et al. · 2025 · Journal of biotechnology · DOI

Full title: A novel dynamic flux balance analysis for modeling CHO cell fed-batch cultures with pH and temperature shifts.

Authors: Ghodba, Ali; Richelle, Anne; McCready, Chris; Ricardez-Sandoval, Luis; Budman, Hector

Year: 2025

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2025.08.010

Paper Impact of temperature and pH on recombinant human IgM quality attributes and productivity.

Hennicke, Julia; Reinhart, David; Altmann, Friedrich et al. · 2019 · New biotechnology · DOI

Full title: Impact of temperature and pH on recombinant human IgM quality attributes and productivity.

Authors: Hennicke, Julia; Reinhart, David; Altmann, Friedrich; Kunert, Renate

Year: 2019

Venue: New biotechnology

DOI: https://doi.org/10.1016/j.nbt.2019.01.001

Paper Assessment of fed-batch cultivation strategies for an inducible CHO cell line.

Mellahi, Kahina; Brochu, Denis; Gilbert, Michel et al. · 2019 · Journal of biotechnology · DOI

Full title: Assessment of fed-batch cultivation strategies for an inducible CHO cell line.

Authors: Mellahi, Kahina; Brochu, Denis; Gilbert, Michel; Perrier, Michel; Ansorge, Sven; Durocher, Yves; Henry, Olivier

Year: 2019

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2019.04.005

Paper CHO genome mining for synthetic promoter design.

Johari, Yusuf B; Brown, Adam J; Alves, Christina S et al. · 2019 · Journal of biotechnology · DOI

Full title: CHO genome mining for synthetic promoter design.

Authors: Johari, Yusuf B; Brown, Adam J; Alves, Christina S; Zhou, Yizhou; Wright, Chapman M; Estes, Scott D; Kshirsagar, Rashmi; James, David C

Year: 2019

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2019.01.015

Paper Dynamic metabolic flux analysis using B-splines to study the effects of temperature shift on CHO cell metabolism.

Martínez, Verónica S; Buchsteiner, Maria; Gray, Peter et al. · 2015 · Metabolic engineering communications · DOI

Full title: Dynamic metabolic flux analysis using B-splines to study the effects of temperature shift on CHO cell metabolism.

Authors: Martínez, Verónica S; Buchsteiner, Maria; Gray, Peter; Nielsen, Lars K; Quek, Lake-Ee

Year: 2015

Venue: Metabolic engineering communications

DOI: https://doi.org/10.1016/j.meteno.2015.06.001

Paper Chemometrics and in-line near infrared spectroscopic monitoring of a biopharmaceutical Chinese hamster ovary cell culture: prediction of multiple cultivation variables.

Clavaud, Matthieu; Roggo, Yves; Von Daeniken, Ralph et al. · 2013 · Talanta · DOI

Full title: Chemometrics and in-line near infrared spectroscopic monitoring of a biopharmaceutical Chinese hamster ovary cell culture: prediction of multiple cultivation variables.

Authors: Clavaud, Matthieu; Roggo, Yves; Von Daeniken, Ralph; Liebler, André; Schwabe, Jan-Oliver

Year: 2013

Venue: Talanta

DOI: https://doi.org/10.1016/j.talanta.2013.03.044

Paper Kinetic modeling: A tool for temperature shift and feeding optimization in cell culture process development.

Wang, Zheyu; Wang, Caixia; Chen, Gong · 2022 · Protein expression and purification · DOI

Full title: Kinetic modeling: A tool for temperature shift and feeding optimization in cell culture process development.

Authors: Wang, Zheyu; Wang, Caixia; Chen, Gong

Year: 2022

Venue: Protein expression and purification

DOI: https://doi.org/10.1016/j.pep.2022.106130

Paper Dynamic model of CHO cell metabolism.

Nolan, Ryan P; Lee, Kyongbum · 2011 · Metabolic engineering · DOI

Full title: Dynamic model of CHO cell metabolism.

Authors: Nolan, Ryan P; Lee, Kyongbum

Year: 2011

Venue: Metabolic engineering

DOI: https://doi.org/10.1016/j.ymben.2010.09.003

Paper Temperature reduction in cultures of hGM-CSF-expressing CHO cells: effect on productivity and product quality.

Bollati-Fogolín, Mariela; Forno, Guillermina; Nimtz, Manfred et al. · 2005 · Biotechnology progress · DOI

Full title: Temperature reduction in cultures of hGM-CSF-expressing CHO cells: effect on productivity and product quality.

Authors: Bollati-Fogolín, Mariela; Forno, Guillermina; Nimtz, Manfred; Conradt, Harald S; Etcheverrigaray, Marina; Kratje, Ricardo

Year: 2005

Venue: Biotechnology progress

DOI: https://doi.org/10.1021/bp049825t

Paper Differential Phosphoproteomic Analysis of Recombinant Chinese Hamster Ovary Cells Following Temperature Shift.

Henry, Michael; Power, Martin; Kaushik, Prashant et al. · 2017 · Journal of proteome research · DOI

Full title: Differential Phosphoproteomic Analysis of Recombinant Chinese Hamster Ovary Cells Following Temperature Shift.

Authors: Henry, Michael; Power, Martin; Kaushik, Prashant; Coleman, Orla; Clynes, Martin; Meleady, Paula

Year: 2017

Venue: Journal of proteome research

DOI: https://doi.org/10.1021/acs.jproteome.6b00868

Paper Proteome-Wide Analysis of N-Glycosylation Stoichiometry Using SWATH Technology.

Yang, Xiangyun; Wang, Zhiyuan; Guo, Lin et al. · 2017 · Journal of proteome research · DOI

Full title: Proteome-Wide Analysis of N-Glycosylation Stoichiometry Using SWATH Technology.

Authors: Yang, Xiangyun; Wang, Zhiyuan; Guo, Lin; Zhu, Zhengjiang; Zhang, Yaoyang

Year: 2017

Venue: Journal of proteome research

DOI: https://doi.org/10.1021/acs.jproteome.7b00480

Paper Temperature shift as a process optimization step for the production of pro-urokinase by a recombinant Chinese hamster ovary cell line in high-density perfusion culture.

Chen, Zhao-Lie; Wu, Ben-Chuan; Liu, Hong et al. · 2004 · Journal of bioscience and bioengineering · DOI

Full title: Temperature shift as a process optimization step for the production of pro-urokinase by a recombinant Chinese hamster ovary cell line in high-density perfusion culture.

Authors: Chen, Zhao-Lie; Wu, Ben-Chuan; Liu, Hong; Liu, Xing-Mao; Huang, Pei-Tang

Year: 2004

Venue: Journal of bioscience and bioengineering

DOI: https://doi.org/10.1016/S1389-1723(04)70198-X

Paper Limited use of Centritech Lab II Centrifuge in perfusion culture of rCHO cells for the production of recombinant antibody.

Kim, Byoung Jin; Oh, Duk Jae; Chang, Ho Nam · 2008 · Biotechnology progress · DOI

Full title: Limited use of Centritech Lab II Centrifuge in perfusion culture of rCHO cells for the production of recombinant antibody.

Authors: Kim, Byoung Jin; Oh, Duk Jae; Chang, Ho Nam

Year: 2008

Venue: Biotechnology progress

DOI: https://doi.org/10.1021/bp070235f

Paper Enhancement of productivity of recombinant alpha-amidating enzyme by low temperature culture.

Furukawa, K; Ohsuye, K · 1999 · Cytotechnology · DOI

Full title: Enhancement of productivity of recombinant alpha-amidating enzyme by low temperature culture.

Authors: Furukawa, K; Ohsuye, K

Year: 1999

Venue: Cytotechnology

DOI: https://doi.org/10.1023/A:1008059803038

Paper Effects of temperature shift on cell cycle, apoptosis and nucleotide pools in CHO cell batch cultues.

Moore, A; Mercer, J; Dutina, G et al. · 1997 · Cytotechnology · DOI

Full title: Effects of temperature shift on cell cycle, apoptosis and nucleotide pools in CHO cell batch cultues.

Authors: Moore, A; Mercer, J; Dutina, G; Donahue, C J; Bauer, K D; Mather, J P; Etcheverry, T; Ryll, T

Year: 1997

Venue: Cytotechnology

DOI: https://doi.org/10.1023/A:1007919921991

Paper Increased productivity of recombinant tissular plasminogen activator (t-PA) by butyrate and shift of temperature: a cell cycle phases analysis.

Hendrick, V; Winnepenninckx, P; Abdelkafi, C et al. · 2001 · Cytotechnology · DOI

Full title: Increased productivity of recombinant tissular plasminogen activator (t-PA) by butyrate and shift of temperature: a cell cycle phases analysis.

Authors: Hendrick, V; Winnepenninckx, P; Abdelkafi, C; Vandeputte, O; Cherlet, M; Marique, T; Renemann, G; Loa, A; Kretzmer, G; Werenne, J

Year: 2001

Venue: Cytotechnology

DOI: https://doi.org/10.1023/A:1014088919546

Paper Mild hypothermia improves transient gene expression yields several fold in Chinese hamster ovary cells.

Wulhfard, Sarah; Tissot, Stéphanie; Bouchet, Sophie et al. · 2008 · Biotechnology progress · DOI

Full title: Mild hypothermia improves transient gene expression yields several fold in Chinese hamster ovary cells.

Authors: Wulhfard, Sarah; Tissot, Stéphanie; Bouchet, Sophie; Cevey, Jean; De Jesus, Maria; Hacker, David L; Wurm, Florian M

Year: 2008

Venue: Biotechnology progress

DOI: https://doi.org/10.1021/bp070286c

Paper Application of a cell-once-through perfusion strategy for production of recombinant antibody from rCHO cells in a Centritech Lab II centrifuge system.

Kim, Byoung Jin; Chang, Ho Nam; Oh, Duk Jae · 2007 · Biotechnology progress · DOI

Full title: Application of a cell-once-through perfusion strategy for production of recombinant antibody from rCHO cells in a Centritech Lab II centrifuge system.

Authors: Kim, Byoung Jin; Chang, Ho Nam; Oh, Duk Jae

Year: 2007

Venue: Biotechnology progress

DOI: https://doi.org/10.1021/bp0700861

Paper Functional annotation of the putative orphan Caenorhabditis elegans G-protein-coupled receptor C10C6.2 as a FLP15 peptide receptor.

Kubiak, Teresa M; Larsen, Martha J; Zantello, Marjorie R et al. · 2003 · The Journal of biological chemistry · DOI

Full title: Functional annotation of the putative orphan Caenorhabditis elegans G-protein-coupled receptor C10C6.2 as a FLP15 peptide receptor.

Authors: Kubiak, Teresa M; Larsen, Martha J; Zantello, Marjorie R; Bowman, Jerry W; Nulf, Susan C; Lowery, David E

Year: 2003

Venue: The Journal of biological chemistry

DOI: https://doi.org/10.1074/jbc.M304056200

Paper ATR (ataxia telangiectasia mutated- and Rad3-related kinase) is activated by mild hypothermia in mammalian cells and subsequently activates p53.

Roobol, Anne; Roobol, Jo; Carden, Martin J et al. · 2011 · The Biochemical journal · DOI

Full title: ATR (ataxia telangiectasia mutated- and Rad3-related kinase) is activated by mild hypothermia in mammalian cells and subsequently activates p53.

Authors: Roobol, Anne; Roobol, Jo; Carden, Martin J; Bastide, Amandine; Willis, Anne E; Dunn, Warwick B; Goodacre, Royston; Smales, C Mark

Year: 2011

Venue: The Biochemical journal

DOI: https://doi.org/10.1042/BJ20101303

Paper Mild hypothermic culture conditions affect residual host cell protein composition post-Protein A chromatography.

Goey, Cher Hui; Bell, David; Kontoravdi, Cleo · 2018 · mAbs · DOI

Full title: Mild hypothermic culture conditions affect residual host cell protein composition post-Protein A chromatography.

Authors: Goey, Cher Hui; Bell, David; Kontoravdi, Cleo

Year: 2018

Venue: mAbs

DOI: https://doi.org/10.1080/19420862.2018.1433977

Paper Systematic development of temperature shift strategies for Chinese hamster ovary cells based on short duration cultures and kinetic modeling.

Xu, Jianlin; Tang, Peifeng; Yongky, Andrew et al. · 2019 · mAbs · DOI

Full title: Systematic development of temperature shift strategies for Chinese hamster ovary cells based on short duration cultures and kinetic modeling.

Authors: Xu, Jianlin; Tang, Peifeng; Yongky, Andrew; Drew, Barry; Borys, Michael C; Liu, Shijie; Li, Zheng Jian

Year: 2019

Venue: mAbs

DOI: https://doi.org/10.1080/19420862.2018.1525262

Paper Development and Qualification of a Scale-Down Mammalian Cell Culture Model and Application in Design Space Development by Definitive Screening Design.

Nie, Lei; Gao, Dong; Jiang, Haiyan et al. · 2019 · AAPS PharmSciTech · DOI

Full title: Development and Qualification of a Scale-Down Mammalian Cell Culture Model and Application in Design Space Development by Definitive Screening Design.

Authors: Nie, Lei; Gao, Dong; Jiang, Haiyan; Gou, Jinxia; Li, Lei; Hu, Feng; Guo, Tingting; Wang, Haibin; Qu, Haibin

Year: 2019

Venue: AAPS PharmSciTech

DOI: https://doi.org/10.1208/s12249-019-1451-7

Paper The Effect of Culture Temperature on the Aggregation of Recombinant TNFR-Fc is Regulated by the PERK-eIF2a Pathway in CHO Cells.

Wang, Kai; Zhang, Tu; Chen, Jing et al. · 2018 · Protein and peptide letters · DOI

Full title: The Effect of Culture Temperature on the Aggregation of Recombinant TNFR-Fc is Regulated by the PERK-eIF2a Pathway in CHO Cells.

Authors: Wang, Kai; Zhang, Tu; Chen, Jing; Liu, Chenxuexuan; Tang, Jie; Xie, Qiuling

Year: 2018

Venue: Protein and peptide letters

DOI: https://doi.org/10.2174/0929866525666180530121317

Paper Optimization of Culture Conditions to Improve Follicle-Stimulating Hormone Production by CHO-DG44 Cells in Serum-Free Medium.

Ghobadian, Hanna; Roshanzamir, Khashayar; Kouhi Abdolabadi, Mohammadhasan et al. · 2024 · Iranian biomedical journal · DOI

Full title: Optimization of Culture Conditions to Improve Follicle-Stimulating Hormone Production by CHO-DG44 Cells in Serum-Free Medium.

Authors: Ghobadian, Hanna; Roshanzamir, Khashayar; Kouhi Abdolabadi, Mohammadhasan; Ostadi, Hadi; Zati Keikha, Reza; Dolatkhah Baghan, Mohammad; Talebkhan, Yeganeh; Torkashvand, Fatemeh

Year: 2024

Venue: Iranian biomedical journal

DOI: https://doi.org/10.61186/ibj.4160

Paper Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells.

Velugula-Yellela, Sai Rashmika; Kohnhorst, Casey; Powers, David N et al. · 2018 · Journal of visualized experiments : JoVE · DOI

Full title: Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells.

Authors: Velugula-Yellela, Sai Rashmika; Kohnhorst, Casey; Powers, David N; Trunfio, Nicholas; Faustino, Anneliese; Angart, Phillip; Berilla, Erica; Faison, Talia; Agarabi, Cyrus

Year: 2018

Venue: Journal of visualized experiments : JoVE

DOI: https://doi.org/10.3791/58231

Paper Beken stromen; leidraad voor ecologisch beekherstel

Verdonschot, P.F.M. · 1995

Full title: Beken stromen; leidraad voor ecologisch beekherstel

Authors: Verdonschot, P.F.M.

Year: 1995

Paper Control of culture environment for improved polyethylenimine-mediated transient production of recombinant monoclonal antibodies by CHO cells.

Galbraith, Douglas J; Tait, Andrew S; Racher, Andrew J et al. · 2006 · Biotechnology progress · DOI

Full title: Control of culture environment for improved polyethylenimine-mediated transient production of recombinant monoclonal antibodies by CHO cells.

Authors: Galbraith, Douglas J; Tait, Andrew S; Racher, Andrew J; Birch, John R; James, David C

Year: 2006

Venue: Biotechnology progress

DOI: https://doi.org/10.1021/bp050339v

Thesis Mild hypothermia improves transient gene expression yields several fold in Chinese hamster ovary cells

Wulhfard, S; Tissot, S; Bouchet, S et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Mild hypothermia improves transient gene expression yields several fold in Chinese hamster ovary cells

Authors: Wulhfard, S; Tissot, S; Bouchet, S; Cevey, J; De Jesus, M; Hacker, DL; Wurm, FM

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41413

Thesis Novel orbital shake bioreactors for transient production of CHO derived IgGs

Stettler, Matthieu; Zhang, Xiaowei; Hacker, David L. et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Novel orbital shake bioreactors for transient production of CHO derived IgGs

Authors: Stettler, Matthieu; Zhang, Xiaowei; Hacker, David L.; De Jesus, Maria; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/83449

Thesis Characterization of Fibra-Cel® packed-bed bioreactors for the culture of CHO cells

Meuwly, Frédéric · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Characterization of Fibra-Cel® packed-bed bioreactors for the culture of CHO cells

Authors: Meuwly, Frédéric

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/218454

Thesis Monitoring of temperature effects on animal cell metabolism in a packed bed process

Ducommun, P.; Rueux, P. A.; Kadouri, A. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Monitoring of temperature effects on animal cell metabolism in a packed bed process

Authors: Ducommun, P.; Rueux, P. A.; Kadouri, A.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226069

Thesis Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing

Lee, Jae Seong; Park, Jin Hyoung; Kwang Ha, Tae et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing

Authors: Lee, Jae Seong; Park, Jin Hyoung; Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Samoudi, Mojtaba; Lewis, Nathan E.; Palsson, Bernhard O.; id_orcid 0000-0003-2357-6785; Kildegaard, Helene Faustrup; Min Lee, Gyun

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0ae89c9f-9a27-4554-a9b0-2af9aa0614a9

Thesis Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing

Lee, Jae Seong; Park, Jin Hyoung; Kwang Ha, Tae et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0ae89c9f-9a27-4554-a9b0-2af9aa0614a9

Thesis Method of designing carbohydrates

Lewis, Nathan; Chiang, Wan-Tien; Liang, Chenguang · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Method of designing carbohydrates

Authors: Lewis, Nathan; Chiang, Wan-Tien; Liang, Chenguang

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ba83157b-c8c3-43b6-8fd5-c238aa8df054

Thesis Effect of Chinese hamster ovary culture PH on sialylation and antibody productivity

McIntosh, Calum John · 2024 · Imperial College London · DOI

Full title: Effect of Chinese hamster ovary culture PH on sialylation and antibody productivity

Authors: McIntosh, Calum John

Year: 2024

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/110593

Thesis Utilising a genome scale metabolic model to design high-producing CHO cell lines through bi-level optimisation

Antonakoudis, Athanasios · 2024 · Imperial College London · DOI

Full title: Utilising a genome scale metabolic model to design high-producing CHO cell lines through bi-level optimisation

Authors: Antonakoudis, Athanasios

Year: 2024

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/110783

Thesis GlyCompute: towards the automated analysis of protein N-linked glycosylation kinetics via an open-source computational framework

Flevaris, Konstantinos; Kotidis, Pavlos; Kontoravdi, Cleo · 2025 · Imperial College London · DOI

Full title: GlyCompute: towards the automated analysis of protein N-linked glycosylation kinetics via an open-source computational framework

Authors: Flevaris, Konstantinos; Kotidis, Pavlos; Kontoravdi, Cleo

Year: 2025

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/39322800

Thesis Cell cycle heterogeneity study by an integrated modelling and experimental approach

Garcia Munzer, David · 2015 · Imperial College London · DOI

Full title: Cell cycle heterogeneity study by an integrated modelling and experimental approach

Authors: Garcia Munzer, David

Year: 2015

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/28085

Thesis Exploring cellular behaviour under transient gene expression and its impact on mAb productivity and Fc glycosylation

Sou, SN; Ken, L; Nayyar, K et al. · 2017 · Imperial College London · DOI

Full title: Exploring cellular behaviour under transient gene expression and its impact on mAb productivity and Fc glycosylation

Authors: Sou, SN; Ken, L; Nayyar, K; Polizzi, KM; Sellick, C; Kontoravdi, C

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/50815

Thesis Model-based investigation of intracellular processes determining antibody Fc-glycosylation under mild hypothermia

Sou, SN; Jedrzejewski, PM; Lee, K et al. · 2016 · Imperial College London · DOI

Full title: Model-based investigation of intracellular processes determining antibody Fc-glycosylation under mild hypothermia

Authors: Sou, SN; Jedrzejewski, PM; Lee, K; Sellick, C; Polizzi, KM; Kontoravdi, C

Year: 2016

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/42617

Thesis Understanding the impact of bioprocess conditions on monoclonal antibody glycosylation in mammalian cell cultures through experimental and computational analyses

Sou, Si Nga · 2018 · Imperial College London · DOI

Full title: Understanding the impact of bioprocess conditions on monoclonal antibody glycosylation in mammalian cell cultures through experimental and computational analyses

Authors: Sou, Si Nga

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/58304

Thesis Cascading effects in bioprocessing: the impact of cell culture environment on CHO cell behaviour and host cell protein species

Goey, Cher Hui · 2017 · Imperial College London · DOI

Full title: Cascading effects in bioprocessing: the impact of cell culture environment on CHO cell behaviour and host cell protein species

Authors: Goey, Cher Hui

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/52703

Thesis Constrained global sensitivity analysis for bioprocess design space identification

Kotidis, Pavlos; Demis, Panagiotis; Goey, Cher et al. · 2019 · Imperial College London · DOI

Full title: Constrained global sensitivity analysis for bioprocess design space identification

Authors: Kotidis, Pavlos; Demis, Panagiotis; Goey, Cher; Correa, Elisa; McIntosh, calum; Trepekli, Stefania; Shah, Nilay; Klymenko, Oleksiy; Kontoravdi, Kleio

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/66121

Thesis CHO cell cultures in shake flasks and bioreactors present different host cell protein profiles in the supernatant

Goey, CH; Bell, D; Kontoravdi, C · 2019 · Imperial College London · DOI

Full title: CHO cell cultures in shake flasks and bioreactors present different host cell protein profiles in the supernatant

Authors: Goey, CH; Bell, D; Kontoravdi, C

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/67420

Thesis Mild hypothermic culture conditions impact residual host cell protein composition post-protein a chromatography

Goey, CH; Bell, David; Kontoravdi, K · 2018 · Imperial College London · DOI

Full title: Mild hypothermic culture conditions impact residual host cell protein composition post-protein a chromatography

Authors: Goey, CH; Bell, David; Kontoravdi, K

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/63191

Thesis Mathematical modelling for bioprocess understanding and optimisation

Alhuthali, Sakhr · 2020 · Imperial College London · DOI

Full title: Mathematical modelling for bioprocess understanding and optimisation

Authors: Alhuthali, Sakhr

Year: 2020

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/84849

Thesis Population balance modelling captures host cell protein dynamics in CHO cell cultures

Alhuthali, Sakhr; Kontoravdi, Cleo · 2022 · Imperial College London · DOI

Full title: Population balance modelling captures host cell protein dynamics in CHO cell cultures

Authors: Alhuthali, Sakhr; Kontoravdi, Cleo

Year: 2022

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/96277

Thesis Cascading effect in bioprocessing – the impact of mild hypothermia on CHO cell behavior and host cell protein composition

Goey, CH; Tsang, J; Bell, D et al. · 2017 · Imperial College London · DOI

Full title: Cascading effect in bioprocessing – the impact of mild hypothermia on CHO cell behavior and host cell protein composition

Authors: Goey, CH; Tsang, J; Bell, D; Kontoravdi, C

Year: 2017

Venue: Imperial College London

DOI: https://onlinelibrary.wiley.com/doi/epdf/10.1002/bit.26437

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2. Data Extraction

0/142 extracted

Paper

Advances in recombinant antibody manufacturing

Kunert, Renate; Reinhart, David · 2016

Full title: Advances in recombinant antibody manufacturing

Authors: Kunert, Renate; Reinhart, David

DOI: https://doi.org/10.1007/s00253-016-7388-9

Paper

Optimum blue light exposure: a means to increase cell-specific productivity in Chinese hamster ovary cells.

Föller, Stefanie; Regett, Niklas; Lataster, Levin et al. · 2024

Full title: Optimum blue light exposure: a means to increase cell-specific productivity in Chinese hamster ovary cells.

Authors: Föller, Stefanie; Regett, Niklas; Lataster, Levin; Radziwill, Gerald; Takors, Ralf

DOI: https://doi.org/10.1007/s00253-024-13363-4

Paper

Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells.

Sumitomo, Yasuhiko; Higashitsuji, Hiroaki; Higashitsuji, Hisako et al. · 2012

Full title: Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells.

Authors: Sumitomo, Yasuhiko; Higashitsuji, Hiroaki; Higashitsuji, Hisako; Liu, Yu; Fujita, Takanori; Sakurai, Toshiharu; Candeias, Marco M; Itoh, Katsuhiko; Chiba, Tsutomu; Fujita, Jun

DOI: https://doi.org/10.1186/1472-6750-12-72

Paper

Differential protein expression following low temperature culture of suspension CHO-K1 cells.

Kumar, Niraj; Gammell, Patrick; Meleady, Paula et al. · 2008

Full title: Differential protein expression following low temperature culture of suspension CHO-K1 cells.

Authors: Kumar, Niraj; Gammell, Patrick; Meleady, Paula; Henry, Michael; Clynes, Martin

DOI: https://doi.org/10.1186/1472-6750-8-42

Paper

Identification of a novel temperature sensitive promoter in CHO cells.

Thaisuchat, Haruthai; Baumann, Martina; Pontiller, Jens et al. · 2011

Full title: Identification of a novel temperature sensitive promoter in CHO cells.

Authors: Thaisuchat, Haruthai; Baumann, Martina; Pontiller, Jens; Hesse, Friedemann; Ernst, Wolfgang

DOI: https://doi.org/10.1186/1472-6750-11-51

Paper

Development of an intensified fed-batch production platform with doubled titers using N-1 perfusion seed for cell culture manufacturing

Xu, Jianlin; Rehmann, Matthew S.; Xu, Mengmeng et al. · 2020

Full title: Development of an intensified fed-batch production platform with doubled titers using N-1 perfusion seed for cell culture manufacturing

Authors: Xu, Jianlin; Rehmann, Matthew S.; Xu, Mengmeng; Zheng, Shun; Hill, Charles G.; He, Qin; Borys, Michael; Li, Zheng Jian

DOI: https://doi.org/10.1186/s40643-020-00304-y

Paper

LDH-C can be differentially expressed during fermentation of CHO cells.

Szperalski, Berthold; Jung, Christine; Shao, Zhixin et al. · 2011

Full title: LDH-C can be differentially expressed during fermentation of CHO cells.

Authors: Szperalski, Berthold; Jung, Christine; Shao, Zhixin; Kantardjieff, Anne; Hu, Wei-Shou

DOI: https://doi.org/10.1186/1753-6561-5-S8-P107

Paper

¹H NMR spectroscopy profiling of metabolic reprogramming of Chinese hamster ovary cells upon a temperature shift during culture.

Wagstaff, Jane L; Masterton, Rosalyn J; Povey, Jane F et al. · 2013

Full title: ¹H NMR spectroscopy profiling of metabolic reprogramming of Chinese hamster ovary cells upon a temperature shift during culture.

Authors: Wagstaff, Jane L; Masterton, Rosalyn J; Povey, Jane F; Smales, C Mark; Howard, Mark J

DOI: https://doi.org/10.1371/journal.pone.0077195

Paper

Improved functional expression of human cardiac kv1.5 channels and trafficking-defective mutants by low temperature treatment.

Ding, Wei-Guang; Xie, Yu; Toyoda, Futoshi et al. · 2014

Full title: Improved functional expression of human cardiac kv1.5 channels and trafficking-defective mutants by low temperature treatment.

Authors: Ding, Wei-Guang; Xie, Yu; Toyoda, Futoshi; Matsuura, Hiroshi

DOI: https://doi.org/10.1371/journal.pone.0092923

Paper

Differential effect of culture temperature and specific growth rate on CHO cell behavior in chemostat culture.

Vergara, Mauricio; Becerra, Silvana; Berrios, Julio et al. · 2014

Full title: Differential effect of culture temperature and specific growth rate on CHO cell behavior in chemostat culture.

Authors: Vergara, Mauricio; Becerra, Silvana; Berrios, Julio; Osses, Nelson; Reyes, Juan; Rodríguez-Moyá, María; Gonzalez, Ramon; Altamirano, Claudia

DOI: https://doi.org/10.1371/journal.pone.0093865

Paper

Therapeutic Fc fusion protein misfolding: A three-phasic cultivation experimental design.

Ghorbani Aghdam, Atefeh; Moradhaseli, Saeed; Jafari, Farnoush et al. · 2019

Full title: Therapeutic Fc fusion protein misfolding: A three-phasic cultivation experimental design.

Authors: Ghorbani Aghdam, Atefeh; Moradhaseli, Saeed; Jafari, Farnoush; Motahari, Paria; Samavat, Sepideh; Mahboudi, Rasoul; Maleknia, Shayan

DOI: https://doi.org/10.1371/journal.pone.0210712

Paper

Decoupling Growth and Protein Production in CHO Cells: A Targeted Approach.

Donaldson, James S; Dale, Matthew P; Rosser, Susan J · 2021

Full title: Decoupling Growth and Protein Production in CHO Cells: A Targeted Approach.

Authors: Donaldson, James S; Dale, Matthew P; Rosser, Susan J

DOI: https://doi.org/10.3389/fbioe.2021.658325

Paper

Endoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat Cultures.

Vergara, Mauricio; Berrios, Julio; Martínez, Irene et al. · 2015

Full title: Endoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat Cultures.

Authors: Vergara, Mauricio; Berrios, Julio; Martínez, Irene; Díaz-Barrera, Alvaro; Acevedo, Cristian; Reyes, Juan G; Gonzalez, Ramon; Altamirano, Claudia

DOI: https://doi.org/10.1371/journal.pone.0144224

Paper

Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Productivity and Product Quality.

Strasser, Lisa; Farrell, Amy; Ho, Jenny T C et al. · 2021

Full title: Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Productivity and Product Quality.

Authors: Strasser, Lisa; Farrell, Amy; Ho, Jenny T C; Scheffler, Kai; Cook, Ken; Pankert, Patrick; Mowlds, Peter; Viner, Rosa; Karger, Barry L; Bones, Jonathan

DOI: https://doi.org/10.3389/fbioe.2021.569045

Paper

Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells.

Torres, Mauro; Zúñiga, Roberto; Gutierrez, Matias et al. · 2018

Full title: Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells.

Authors: Torres, Mauro; Zúñiga, Roberto; Gutierrez, Matias; Vergara, Mauricio; Collazo, Norberto; Reyes, Juan; Berrios, Julio; Aguillon, Juan Carlos; Molina, Maria Carmen; Altamirano, Claudia

DOI: https://doi.org/10.1371/journal.pone.0194510

Paper

High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells.

Vergara, Mauricio; Torres, Mauro; Müller, Andrea et al. · 2018

Full title: High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells.

Authors: Vergara, Mauricio; Torres, Mauro; Müller, Andrea; Avello, Verónica; Acevedo, Cristian; Berrios, Julio; Reyes, Juan G; Valdez-Cruz, Norma A; Altamirano, Claudia

DOI: https://doi.org/10.1371/journal.pone.0202098

Paper

Enhancing productivity of Chinese hamster ovary (CHO) cells: synergistic strategies combining low-temperature culture and mTORC1 signaling engineering.

Shahabi, Farzaneh; Abdoli, Shahriyar; Bazi, Zahra et al. · 2023

Full title: Enhancing productivity of Chinese hamster ovary (CHO) cells: synergistic strategies combining low-temperature culture and mTORC1 signaling engineering.

Authors: Shahabi, Farzaneh; Abdoli, Shahriyar; Bazi, Zahra; Shamsabadi, Fatemeh; Yamchi, Ahad; Shahbazi, Majid

DOI: https://doi.org/10.3389/fbioe.2023.1268048

Paper

High-Level Production of scFv-Fc Antibody Using an Artificial Promoter System with Transcriptional Positive Feedback Loop of Transactivator in CHO Cells.

Ying, Binbin; Kawabe, Yoshinori; Zheng, Feiyang et al. · 2023

Full title: High-Level Production of scFv-Fc Antibody Using an Artificial Promoter System with Transcriptional Positive Feedback Loop of Transactivator in CHO Cells.

Authors: Ying, Binbin; Kawabe, Yoshinori; Zheng, Feiyang; Amamoto, Yuki; Kamihira, Masamichi

DOI: https://doi.org/10.3390/cells12222638

Paper

Reduced Culture Temperature Differentially Affects Expression and Biophysical Properties of Monoclonal Antibody Variants.

Mason, Megan; Sweeney, Bernadette; Cain, Katharine et al. · 2014

Full title: Reduced Culture Temperature Differentially Affects Expression and Biophysical Properties of Monoclonal Antibody Variants.

Authors: Mason, Megan; Sweeney, Bernadette; Cain, Katharine; Stephens, Paul; Sharfstein, Susan T

DOI: https://doi.org/10.3390/antib3030253

Paper

Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments.

Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald et al. · 2021

Full title: Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments.

Authors: Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald; Sissolak, Bernhard

DOI: https://doi.org/10.3389/fbioe.2021.740215

Paper

The Effect of Culture Temperature on Recombinant IFN-γ Production and Quality

Fox, Steven R.; Yap, Miranda G.S.; Wang, Daniel I. C. · 2004

Full title: The Effect of Culture Temperature on Recombinant IFN-γ Production and Quality

Authors: Fox, Steven R.; Yap, Miranda G.S.; Wang, Daniel I. C.

Thesis

Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia et al. · 2012

Full title: Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76323

Thesis

Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells

Meuwly, F.; von Stockar, U.; Kadouri, A. · 2006

Full title: Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells

Authors: Meuwly, F.; von Stockar, U.; Kadouri, A.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226104

Thesis

Impact on product quality of high productive GS-CHO cell lines.

Perani, A; Gloria, B; Wang, D et al. · 2022

Full title: Impact on product quality of high productive GS-CHO cell lines.

Authors: Perani, A; Gloria, B; Wang, D; Murphy, R; Singh, HK; Smyth, FE; Scott, AM

DOI: https://hdl.handle.net/11343/303930

Thesis

Variations in critical quality attributes (CQAs) on therapeutic monoclonal antibodies (mAbs) due to cultivation conditions, storage conditions and external stress-factors

Nash, Felicia; Sannum, Emma · 2024

Full title: Variations in critical quality attributes (CQAs) on therapeutic monoclonal antibodies (mAbs) due to cultivation conditions, storage conditions and external stress-factors

Authors: Nash, Felicia; Sannum, Emma

DOI: http://lup.lub.lu.se/student-papers/record/9170581

Thesis

FIA-Based Process Monitoring in Simulated Bioreactor for Monoclonal Antibody Production

Fernandez Alcantara, Leonardo Renzo · 2025

Full title: FIA-Based Process Monitoring in Simulated Bioreactor for Monoclonal Antibody Production

Authors: Fernandez Alcantara, Leonardo Renzo

DOI: http://lup.lub.lu.se/student-papers/record/9188201

Thesis

Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis

Transcriptome analysis in mammalian cell culture: Applications in process development and characterization.

Kantardjieff, Anne · 2011

Full title: Transcriptome analysis in mammalian cell culture: Applications in process development and characterization.

Authors: Kantardjieff, Anne

DOI: http://purl.umn.edu/116703

Thesis

The Assessment of MAb Quality and Quantity

Drouillard, Gerald · 2015

Full title: The Assessment of MAb Quality and Quantity

Authors: Drouillard, Gerald

DOI: http://hdl.handle.net/10214/8743

Thesis

Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Zhang, Liang · 2020

Full title: Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Authors: Zhang, Liang

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-273343

Thesis

A computational framework for predicting CHO cell culture performance in bioreactors

Cárcamo Behrens, Martín. · 2019

Full title: A computational framework for predicting CHO cell culture performance in bioreactors

Authors: Cárcamo Behrens, Martín.

DOI: https://hdl.handle.net/1721.1/123055

Thesis

Active hypothermic growth : a novel means for increasing total recombinant protein production by CHO cells

Fox, Stephen Richard · 2008

Full title: Active hypothermic growth : a novel means for increasing total recombinant protein production by CHO cells

Authors: Fox, Stephen Richard

DOI: http://dspace.mit.edu/handle/1721.1/32333

Thesis

Glycosylation site occupancy heterogeneity in Chinese hamster ovary cell culture

Nyberg, Gregg B. (Gregg Bartell), 1970- · 2005

Full title: Glycosylation site occupancy heterogeneity in Chinese hamster ovary cell culture

Authors: Nyberg, Gregg B. (Gregg Bartell), 1970-

DOI: http://hdl.handle.net/1721.1/28190

Thesis

Quantitative Analysis of Proteome Dynamics in Chinese Hamster Ovary cells

Florczak, Beata D · 2019

Full title: Quantitative Analysis of Proteome Dynamics in Chinese Hamster Ovary cells

Authors: Florczak, Beata D

DOI: https://etheses.whiterose.ac.uk/id/eprint/25823/1/B.Florczak_thesis.pdf

Thesis

Cell Line and Process Development for Improved Transient Production of a "Difficult-to-Express" Fusion Protein by CHO Cells

Johari, YB · 2015

Full title: Cell Line and Process Development for Improved Transient Production of a "Difficult-to-Express" Fusion Protein by CHO Cells

Authors: Johari, YB

DOI: https://etheses.whiterose.ac.uk/id/eprint/9265/1/PhD%20thesis%20-%20YB%20Johari%20%5BFINAL%5D.pdf

Thesis

Combining ion mobility spectrometry and cryogenic ion spectroscopy with enzymatic digestion/synthesis for the study of N-linked glycans

Märki, Irina · 2023

Full title: Combining ion mobility spectrometry and cryogenic ion spectroscopy with enzymatic digestion/synthesis for the study of N-linked glycans

Authors: Märki, Irina

DOI: https://infoscience.epfl.ch/handle/20.500.14299/194229

Thesis

Transient recombinant protein expression in mammalian cells : the role of mRNA level and stability

Wulhfard, Sarah · 2009

Full title: Transient recombinant protein expression in mammalian cells : the role of mRNA level and stability

Authors: Wulhfard, Sarah

DOI: https://infoscience.epfl.ch/handle/20.500.14299/36998

Thesis

Estudio transcriptómico y proteómico de células CHO productoras de glicoproteínas recombinantes hipotermia moderada

Bedoya López, Andrea · 2021

Full title: Estudio transcriptómico y proteómico de células CHO productoras de glicoproteínas recombinantes hipotermia moderada

Authors: Bedoya López, Andrea

DOI: https://hdl.handle.net/20.500.14330/TES01000755371

Thesis

Small-molecule control of antibody N-glycosylation in engineered mammalian cells

Chang, Michelle; Gaidukov, Leonid; Jung, Giyoung et al. · 2020

Full title: Small-molecule control of antibody N-glycosylation in engineered mammalian cells

DOI: https://hdl.handle.net/1721.1/125977

Thesis

Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

Sumit, Madhuresh; Dolatshahi, Sepideh; Chu, An-Hsiang Adam et al. · 2020

Full title: Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

DOI: https://hdl.handle.net/1721.1/125974

Thesis

XBP1s Links the Unfolded Protein Response to the Molecular Architecture of Mature N-Glycans

Antonopoulos, Aristotelis; Haslam, Stuart M.; Dell, Anne et al. · 2017

Full title: XBP1s Links the Unfolded Protein Response to the Molecular Architecture of Mature N-Glycans

Authors: Antonopoulos, Aristotelis; Haslam, Stuart M.; Dell, Anne; Dewal, Mahender; DiChiara, Andrew Stephen; Taylor, Rebecca J.; Harmon, Chyleigh J.; Shoulders, Matthew D.

DOI: http://hdl.handle.net/1721.1/106600

Thesis

Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe et al. · 2016

Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

Authors: López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe; Carrillo-Cocom, Leydi Maribel; Rocha-Pizaña, María del Refugio; Alvarez, Mario Moises

DOI: http://hdl.handle.net/1721.1/105504

Thesis

CIRP Expression on Growth and Productivity of CHO Cells

Tan, Hong-Kiat; Yap, Miranda G.S.; Wang, Daniel I.C. · 2005

Full title: CIRP Expression on Growth and Productivity of CHO Cells

Authors: Tan, Hong-Kiat; Yap, Miranda G.S.; Wang, Daniel I.C.

DOI: http://hdl.handle.net/1721.1/30382

Thesis

The Effect of Culture Temperature on Recombinant IFN-γ Production and Quality

Fox, Steven R.; Yap, Miranda G.S.; Wang, Daniel I.C. · 2003

Full title: The Effect of Culture Temperature on Recombinant IFN-γ Production and Quality

Authors: Fox, Steven R.; Yap, Miranda G.S.; Wang, Daniel I.C.

DOI: http://hdl.handle.net/1721.1/3928

Thesis

Reduced Temperature Production of Recombinant Proteins to Increase Productivity in Mammalian Cell Culture

Fox, Steven R.; Wang, Daniel I.C.; Yap, Miranda G.S. · 2003

Full title: Reduced Temperature Production of Recombinant Proteins to Increase Productivity in Mammalian Cell Culture

Authors: Fox, Steven R.; Wang, Daniel I.C.; Yap, Miranda G.S.

DOI: http://hdl.handle.net/1721.1/3946

Thesis

Engineering Mammalian Cells for Improved Recombinant Protein Production

Wong, Niki S.C.; Tan, Hong-Kiat; Wang, Daniel I.C. et al. · 2003

Full title: Engineering Mammalian Cells for Improved Recombinant Protein Production

Authors: Wong, Niki S.C.; Tan, Hong-Kiat; Wang, Daniel I.C.; Yap, Miranda G.S.

DOI: http://hdl.handle.net/1721.1/3781

Thesis

Active Hypothermic Growth: A Novel Means For Increasing Total Interferon-γ Production by Chinese Hamster Ovary Cells

Stephen R., Fox; Yap, Mei Xia; Yap, Miranda G.S. et al. · 2005

Full title: Active Hypothermic Growth: A Novel Means For Increasing Total Interferon-γ Production by Chinese Hamster Ovary Cells

Authors: Stephen R., Fox; Yap, Mei Xia; Yap, Miranda G.S.; Wang, Daniel I.C.

DOI: http://hdl.handle.net/1721.1/30379

Thesis

Cell-line Engineering for Low-temperature Growth

Tan, Hong-Kiat; Yap, Miranda G.S.; Wang, Daniel I.C. · 2003

Full title: Cell-line Engineering for Low-temperature Growth

Authors: Tan, Hong-Kiat; Yap, Miranda G.S.; Wang, Daniel I.C.

DOI: http://hdl.handle.net/1721.1/3926

Thesis

Directed evolution of Chinese Hamster Ovary cells

Syddall, Katie Louise · 2016

Full title: Directed evolution of Chinese Hamster Ovary cells

Authors: Syddall, Katie Louise

DOI: https://etheses.whiterose.ac.uk/id/eprint/13836/1/Thesis_FINAL_Post_Corrections_AUG16_KatieSyddall.pdf

Thesis

Influence of cell-line and process conditions on the glycosylation of recombinant proteins

Nahrgang, Stefan · 2005

Full title: Influence of cell-line and process conditions on the glycosylation of recombinant proteins

Authors: Nahrgang, Stefan

DOI: https://infoscience.epfl.ch/handle/20.500.14299/211632

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Impact Of Temperature Shift Timing On Cho Cell Cul

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