Fed Batch Feeding Strategies For Cho Cell Cultures

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Paper Process transfer and optimization of Chinese hamster ovary cell cultivation for monoclonal antibody production

Nagraik, Tamanna · 2021 · Institutional Repository of Leibniz Universität Hannover (Leibniz Universität Hannover) · DOI

Full title: Process transfer and optimization of Chinese hamster ovary cell cultivation for monoclonal antibody production

Authors: Nagraik, Tamanna

Year: 2021

Venue: Institutional Repository of Leibniz Universität Hannover (Leibniz Universität Hannover)

DOI: https://doi.org/10.15488/10601

Paper The Biological Impact of High Throughput Continuous Bioprocessing

Sewell, David · 2020 · Apollo (University of Cambridge) · DOI

Full title: The Biological Impact of High Throughput Continuous Bioprocessing

Authors: Sewell, David

Year: 2020

Venue: Apollo (University of Cambridge)

DOI: https://doi.org/10.17863/cam.58800

Paper Multi-omics analysis of Chinese hamster ovary cell-based biopharmaceutical production processes

Ali, Amr · 2019 · DOI

Full title: Multi-omics analysis of Chinese hamster ovary cell-based biopharmaceutical production processes

Authors: Ali, Amr

Year: 2019

DOI: https://doi.org/10.17760/d20318588

Paper Transcriptomic profiling as a tool to characterize CHO cell processes

Sayyari, Abdulaziz Abdullah Al · 2018 · DOI

Full title: Transcriptomic profiling as a tool to characterize CHO cell processes

Authors: Sayyari, Abdulaziz Abdullah Al

Year: 2018

DOI: https://doi.org/10.18174/460722

Paper Process intensification for CHO cell biomanufacturing

Schulze, Markus · 2023 · DOI

Full title: Process intensification for CHO cell biomanufacturing

Authors: Schulze, Markus

Year: 2023

DOI: https://doi.org/10.18174/585711

Paper Scale-down of CHO cell fed-batch cultures

Pan, Xiao · 2018 · DOI

Full title: Scale-down of CHO cell fed-batch cultures

Authors: Pan, Xiao

Year: 2018

DOI: https://doi.org/10.18174/444363

Paper Hybrid Modelling and Multi- Parametric Control of Bioprocesses

Zahel, Thomas · 2018 · Name. Year. · DOI

Full title: Hybrid Modelling and Multi- Parametric Control of Bioprocesses

Authors: Zahel, Thomas

Year: 2018

Venue: Name. Year.

DOI: https://doi.org/10.3390/books978-3-03842-746-9

Paper Applications of Machine Learning in Biopharmaceutical Process Development and Manufacturing: Current Trends, Challenges, and Opportunities

Khuat, Thanh Tung; Bassett, Robert; Otte, Ellen et al. · 2023 · arXiv (Cornell University) · DOI

Full title: Applications of Machine Learning in Biopharmaceutical Process Development and Manufacturing: Current Trends, Challenges, and Opportunities

Authors: Khuat, Thanh Tung; Bassett, Robert; Otte, Ellen; Grevis-James, Alistair; Gabryś, Bogdan

Year: 2023

Venue: arXiv (Cornell University)

DOI: https://doi.org/10.48550/arxiv.2310.09991

Paper Impact de la modification du métabolisme primaire des cellules CHO sur leur productivité

Toussaint, Cécile · 2016 · DOI

Full title: Impact de la modification du métabolisme primaire des cellules CHO sur leur productivité

Authors: Toussaint, Cécile

Year: 2016

DOI: https://doi.org/10.71781/30210

Paper When Bioprocess Engineering Meets Machine Learning: A Survey from the Perspective of Automated Bioprocess Development

Duong‐Trung, Nghia; Born, Stefan; Kim, Jong Woo et al. · 2022 · arXiv (Cornell University) · DOI

Full title: When Bioprocess Engineering Meets Machine Learning: A Survey from the Perspective of Automated Bioprocess Development

Authors: Duong‐Trung, Nghia; Born, Stefan; Kim, Jong Woo; Schermeyer, Marie‐Therese; Paulick, Katharina; Borisyak, M.; Martı́nez, Ernesto; Bournazou, Mariano Nicolás Cruz; Werner, Thorben; Scholz, Randolf; Schmidt-Thieme, Lars; Neubauer, Peter

Year: 2022

Venue: arXiv (Cornell University)

DOI: https://doi.org/10.48550/arxiv.2209.01083

Paper Amélioration de la production et de la qualité des protéines thérapeutiques recombinantes produites en culture en mode cuvée-alimentée de cellules de mammifère

Karengera, Eric · 2017 · PolyPublie (École Polytechnique de Montréal)

Full title: Amélioration de la production et de la qualité des protéines thérapeutiques recombinantes produites en culture en mode cuvée-alimentée de cellules de mammifère

Authors: Karengera, Eric

Year: 2017

Venue: PolyPublie (École Polytechnique de Montréal)

Paper Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation and ER stress in CHO cells

Sinharoy, Pritam; Aziz, Aaron H.; Majewska, Natalia I. et al. · 2020 · Scientific Reports · DOI

Full title: Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation and ER stress in CHO cells

Authors: Sinharoy, Pritam; Aziz, Aaron H.; Majewska, Natalia I.; Ahuja, Sanjeev; Handlogten, Michael W.

Year: 2020

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-020-73573-4

Paper Real-time characterization of mammalian cell culture bioprocesses by magnetic sector MS

Floris, Patrick; Dorival–García, Noemí; Lewis, Graham et al. · 2020 · Analytical Methods · DOI

Full title: Real-time characterization of mammalian cell culture bioprocesses by magnetic sector MS

Authors: Floris, Patrick; Dorival–García, Noemí; Lewis, Graham; Josland, G.D.; Merriman, Daniel; Bones, Jonathan

Year: 2020

Venue: Analytical Methods

DOI: https://doi.org/10.1039/d0ay01563f

Paper Systematic data-driven genome-scale metabolic model reduction for dynamic bioprocess modeling: CHO cell culture case study

Richelle, Anne; Antonakoudis, Athanasios · 2025 · DOI

Full title: Systematic data-driven genome-scale metabolic model reduction for dynamic bioprocess modeling: CHO cell culture case study

Authors: Richelle, Anne; Antonakoudis, Athanasios

Year: 2025

DOI: https://doi.org/10.1101/2025.10.02.679947

Paper Temporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch and Perfusion Bioreactor Operation

Gyorgypal, Aron; Fratz‐Berilla, Erica J.; Kohnhorst, Casey et al. · 2023 · DOI

Full title: Temporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch and Perfusion Bioreactor Operation

Authors: Gyorgypal, Aron; Fratz‐Berilla, Erica J.; Kohnhorst, Casey; Powers, David N.; Chundawat, Shishir P. S.

Year: 2023

DOI: https://doi.org/10.1101/2023.04.15.535602

Paper Automated Workflow for Instant Labeling and Real-Time Monitoring of Monoclonal Antibody N-Glycosylation

Gyorgypal, Aron; Potter, Oscar G.; Chaturvedi, Antash et al. · 2022 · DOI

Full title: Automated Workflow for Instant Labeling and Real-Time Monitoring of Monoclonal Antibody N-Glycosylation

Authors: Gyorgypal, Aron; Potter, Oscar G.; Chaturvedi, Antash; Powers, David N.; Chundawat, Shishir P. S.

Year: 2022

DOI: https://doi.org/10.1101/2022.12.22.521623

Paper Overcoming the Limits of Traditional Rate Calculations from Sparse Concentration Data: A Probabilistic Framework for Bioprocess Modeling

Richelle, Anne; Andersson, David Emanuel; Vernersson, Anton et al. · 2025 · DOI

Full title: Overcoming the Limits of Traditional Rate Calculations from Sparse Concentration Data: A Probabilistic Framework for Bioprocess Modeling

Authors: Richelle, Anne; Andersson, David Emanuel; Vernersson, Anton; Cloarec, Olivier; Trygg, Johan

Year: 2025

DOI: https://doi.org/10.1101/2025.09.30.679468

Paper An Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-linked Glycosylation

Gyorgypal, Aron; Chundawat, Shishir P. S. · 2021 · DOI

Full title: An Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-linked Glycosylation

Authors: Gyorgypal, Aron; Chundawat, Shishir P. S.

Year: 2021

DOI: https://doi.org/10.1101/2021.11.14.468439

Paper Model-based intensification of CHO cell cultures: one-step strategy from fed-batch to perfusion

Richelle, Anne; Corbett, Brandon; Agarwal, Piyush et al. · 2022 · DOI

Full title: Model-based intensification of CHO cell cultures: one-step strategy from fed-batch to perfusion

Authors: Richelle, Anne; Corbett, Brandon; Agarwal, Piyush; Vernersson, Anton; Trygg, Johan; McCready, Chris

Year: 2022

DOI: https://doi.org/10.1101/2022.05.19.492635

Paper Debottlenecking and reformulating feed media for improved CHO cell growth and titer by data‐driven and model‐guided analyses

Park, Seo‐Young; Choi, Dong‐Hyuk; Song, Jinsung et al. · 2023 · Biotechnology Journal · DOI

Full title: Debottlenecking and reformulating feed media for improved CHO cell growth and titer by data‐driven and model‐guided analyses

Authors: Park, Seo‐Young; Choi, Dong‐Hyuk; Song, Jinsung; Park, Uiseon; Cho, Hyeran; Hong, Bee Hak; Silberberg, Yaron; Lee, Dong‐Yup

Year: 2023

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202300126

Paper Multi-omic characterization of antibody-producing CHO cell lines elucidates metabolic reprogramming and nutrient uptake bottlenecks

Gopalakrishnan, Saratram; Johnson, William; Valderrama-Gomez, Miguel A. et al. · 2023 · DOI

Full title: Multi-omic characterization of antibody-producing CHO cell lines elucidates metabolic reprogramming and nutrient uptake bottlenecks

Authors: Gopalakrishnan, Saratram; Johnson, William; Valderrama-Gomez, Miguel A.; Içten, Elçin; Tat, Jasmine; Lay, Fides D.; Diep, Jonathan; Gómez, Natalia; Stevens, Jennitte; Schlegel, Fabrice; Rolandi, Pablo; Kontoravdi, Cleo; Lewis, Nathan E.

Year: 2023

DOI: https://doi.org/10.1101/2023.09.13.557626

Paper Implementation of Design of Experiments (DOE) for Optimization of Feeding Strategy and Glyco-Engineering of Trastuzumab Biosimilar

Mahboudi, Rasoul; Samavat, Sepideh; Afrah, Amir et al. · 2019 · DOI

Full title: Implementation of Design of Experiments (DOE) for Optimization of Feeding Strategy and Glyco-Engineering of Trastuzumab Biosimilar

Authors: Mahboudi, Rasoul; Samavat, Sepideh; Afrah, Amir; Khorshidtalab, Mehdi; Tehran, Arezou Fadaei; Motahari, Paria; Sofla, Farnoush Jafari Iri; Maleknia, Shayan

Year: 2019

DOI: https://doi.org/10.1101/584144

Paper Evaluation of the advanced micro-scale bioreactor (ambr™) as a highthroughput tool for cell culture process development

Delouvroy, Frédéric; Révérend, Guillaume Le; Fessler, Boris et al. · 2013 · BMC Proceedings · DOI

Full title: Evaluation of the advanced micro-scale bioreactor (ambr™) as a highthroughput tool for cell culture process development

Authors: Delouvroy, Frédéric; Révérend, Guillaume Le; Fessler, Boris; Mathy, Grégory; Harmsen, Mareike; Kochanowski, Nadine; Malphettes, Laetitia

Year: 2013

Venue: BMC Proceedings

DOI: https://doi.org/10.1186/1753-6561-7-s6-p73

Paper A Hybrid Modeling Framework for Predictive Digital Twins of CHO Cell Culture

Richelle, Anne; Andersson, David Emanuel; Antonakoudis, Athanasios et al. · 2025 · DOI

Full title: A Hybrid Modeling Framework for Predictive Digital Twins of CHO Cell Culture

Authors: Richelle, Anne; Andersson, David Emanuel; Antonakoudis, Athanasios; Jakobsson, Jesper; Pijeaud, Shanti; Vernersson, Anton; Trygg, Johan

Year: 2025

DOI: https://doi.org/10.1101/2025.11.24.690194

Paper Medium and feed optimization for fed-batch production of a monoclonal antibody in CHO cells

Kochanowski, Nadine; Siriez, Gaetan; Roosens, Sarah et al. · 2011 · BMC Proceedings · DOI

Full title: Medium and feed optimization for fed-batch production of a monoclonal antibody in CHO cells

Authors: Kochanowski, Nadine; Siriez, Gaetan; Roosens, Sarah; Malphettes, Laetitia

Year: 2011

Venue: BMC Proceedings

DOI: https://doi.org/10.1186/1753-6561-5-s8-p75

Paper Identification of performance drivers for an antibody producing CHO-S cell line culture in the Allegro™ XRS 20 single-use bioreactor utilizing historical data

Sanderson, T.; Martino, A.; Wang, Ing-Kae et al. · 2015 · BMC Proceedings · DOI

Full title: Identification of performance drivers for an antibody producing CHO-S cell line culture in the Allegro™ XRS 20 single-use bioreactor utilizing historical data

Authors: Sanderson, T.; Martino, A.; Wang, Ing-Kae; Rose, Amanda; Rees, Byron; Bradbury, Lisa

Year: 2015

Venue: BMC Proceedings

DOI: https://doi.org/10.1186/1753-6561-9-s9-p33

Paper Understanding and Controlling Sialylation in a CHO Fc-Fusion Process

Lewis, Amanda M.; Croughan, William D.; Aranı́bar, Nelly et al. · 2016 · PLoS ONE · DOI

Full title: Understanding and Controlling Sialylation in a CHO Fc-Fusion Process

Authors: Lewis, Amanda M.; Croughan, William D.; Aranı́bar, Nelly; Lee, Alison G.; Warrack, Bethanne M.; Abu‐Absi, Nicholas R.; Patel, Rutva; Drew, Barry; Borys, Michael; Reily, Michael D.; Li, Zheng Jian

Year: 2016

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0157111

Paper In Situ Monitoring of Intracellular Glucose and Glutamine in CHO Cell Culture

Behjousiar, Alireza; Kontoravdi, Cleo; Polizzi, Karen M. · 2012 · PLoS ONE · DOI

Full title: In Situ Monitoring of Intracellular Glucose and Glutamine in CHO Cell Culture

Authors: Behjousiar, Alireza; Kontoravdi, Cleo; Polizzi, Karen M.

Year: 2012

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0034512

Paper Integrating real-time OUR monitoring with adaptive feeding for enhanced antibody production

Zhang, Xinran; Ran, Qingyuan; Zhang, Botao et al. · 2025 · Bioresources and Bioprocessing · DOI

Full title: Integrating real-time OUR monitoring with adaptive feeding for enhanced antibody production

Authors: Zhang, Xinran; Ran, Qingyuan; Zhang, Botao; He, Yongmei; Zhao, Liang; Tan, Wen‐Song; Ye, Qian

Year: 2025

Venue: Bioresources and Bioprocessing

DOI: https://doi.org/10.1186/s40643-025-00961-x

Paper The successful transfer of a modern CHO fed-batch process to different single-use bioreactors

Ruhl, S. F.; Husemann, Ute; Jurkiewicz, Elke et al. · 2013 · BMC Proceedings · DOI

Full title: The successful transfer of a modern CHO fed-batch process to different single-use bioreactors

Authors: Ruhl, S. F.; Husemann, Ute; Jurkiewicz, Elke; Dreher, Thomas; Greller, Gerhard

Year: 2013

Venue: BMC Proceedings

DOI: https://doi.org/10.1186/1753-6561-7-s6-p32

Paper Deciphering Metabolic Pathways in High Seeding Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective

Bokelmann, Carolin; Ehsani, Alireza; Schaub, Jochen et al. · 2024 · Preprints.org · DOI

Full title: Deciphering Metabolic Pathways in High Seeding Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective

Authors: Bokelmann, Carolin; Ehsani, Alireza; Schaub, Jochen; Stiefel, Fabian

Year: 2024

Venue: Preprints.org

DOI: https://doi.org/10.20944/preprints202402.1474.v1

Paper From Shallow to Deep Bioprocess Hybrid Modeling: Advances and Future Perspectives

Agharafeie, Roshanak; Ramos, João R. C.; Mendes, Jorge M. et al. · 2023 · Fermentation · DOI

Full title: From Shallow to Deep Bioprocess Hybrid Modeling: Advances and Future Perspectives

Authors: Agharafeie, Roshanak; Ramos, João R. C.; Mendes, Jorge M.; Oliveira, Rui

Year: 2023

Venue: Fermentation

DOI: https://doi.org/10.3390/fermentation9100922

Paper Process Mapping and Optimization Study of CHO Cell Cultures for mAb Production using Ambr® 250 High-throughput Parallel Bioreactors

Bordoloi, Achinta; Talebnia, Farid · 2025 · DOI

Full title: Process Mapping and Optimization Study of CHO Cell Cultures for mAb Production using Ambr® 250 High-throughput Parallel Bioreactors

Authors: Bordoloi, Achinta; Talebnia, Farid

Year: 2025

DOI: https://doi.org/10.21203/rs.3.rs-6831589/v1

Paper Self-Driving Development of Perfusion Processes for Monoclonal Antibody Production

Müller, Claudio; Vuillemin, Thomas; Gadiyar, Chethana Janardhana et al. · 2024 · DOI

Full title: Self-Driving Development of Perfusion Processes for Monoclonal Antibody Production

Authors: Müller, Claudio; Vuillemin, Thomas; Gadiyar, Chethana Janardhana; Bielser, Jean‐Marc; Souquet, Jonathan; Fagnani, Alessandro; Sokolov, Michael; Stosch, Moritz von; Feidl, Fabian; Butté, Alessandro; Bournazou, Mariano Nicolás Cruz

Year: 2024

DOI: https://doi.org/10.32388/xufb08

Paper Boosting Productivity for Advanced Biomanufacturing by Re-Using Viable Cells

Reger, Lucas Nik; Saballus, Martin; Matuszczyk, Jens et al. · 2023 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Boosting Productivity for Advanced Biomanufacturing by Re-Using Viable Cells

Authors: Reger, Lucas Nik; Saballus, Martin; Matuszczyk, Jens; Kampmann, Markus; Wijffels, René H.; Martens, Dirk E.; Niemann, Julia

Year: 2023

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2023.1106292

Paper Engineering protein glycosylation in CHO cells to be highly similar to murine host cells

Gupta, Shivani; Shah, Bhavana; Fung, Coral Shek et al. · 2023 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Engineering protein glycosylation in CHO cells to be highly similar to murine host cells

Authors: Gupta, Shivani; Shah, Bhavana; Fung, Coral Shek; Chan, Pik K.; Wakefield, Devin L.; Kuhns, Scott; Goudar, Chetan T.; Piret, James M.

Year: 2023

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2023.1113994

Paper Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments

Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald et al. · 2021 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments

Authors: Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald; Sissolak, Bernhard

Year: 2021

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2021.740215

Paper A novel hybrid bioprocess strategy addressing key challenges of advanced biomanufacturing

Reger, Lucas Nik; Saballus, Martin; Kappes, Annika et al. · 2023 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: A novel hybrid bioprocess strategy addressing key challenges of advanced biomanufacturing

Authors: Reger, Lucas Nik; Saballus, Martin; Kappes, Annika; Kampmann, Markus; Wijffels, René H.; Martens, Dirk E.; Niemann, Julia

Year: 2023

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2023.1211410

Paper Cell specific perfusion rates drive growth dynamics and metabolism in CHO N-1 perfusion processes independent of perfusion rate control method

Walther, Julia; Costa, Tiago Ribeiro da; Winkler, Lydia et al. · 2025 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Cell specific perfusion rates drive growth dynamics and metabolism in CHO N-1 perfusion processes independent of perfusion rate control method

Authors: Walther, Julia; Costa, Tiago Ribeiro da; Winkler, Lydia; Schaub, Jochen; Habicher, Tobias

Year: 2025

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2025.1608889

Paper Modulating antibody N-glycosylation through feed additives using a multi-tiered approach

Kranjc, Jaka; Kramer, Lovro; Mikelj, Miha et al. · 2024 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Modulating antibody N-glycosylation through feed additives using a multi-tiered approach

Authors: Kranjc, Jaka; Kramer, Lovro; Mikelj, Miha; Anderluh, Marko; Pišlar, Anja; Brinc, Matjaž

Year: 2024

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2024.1448925

Paper Bioprocess feeding optimization through in silico dynamic experiments and hybrid digital models—a proof of concept

Barberi, Gianmarco; Giacopuzzi, Christian; Facco, Pierantonio · 2024 · Frontiers in Chemical Engineering · DOI

Full title: Bioprocess feeding optimization through in silico dynamic experiments and hybrid digital models—a proof of concept

Authors: Barberi, Gianmarco; Giacopuzzi, Christian; Facco, Pierantonio

Year: 2024

Venue: Frontiers in Chemical Engineering

DOI: https://doi.org/10.3389/fceng.2024.1456402

Paper Navigating industry 4.0 and 5.0: the role of hybrid modelling in (bio)chemical engineering’s digital transition

Gargalo, Carina L.; Malanca, Alina Anamaria; Aouichaoui, Adem R.N. et al. · 2024 · Frontiers in Chemical Engineering · DOI

Full title: Navigating industry 4.0 and 5.0: the role of hybrid modelling in (bio)chemical engineering’s digital transition

Authors: Gargalo, Carina L.; Malanca, Alina Anamaria; Aouichaoui, Adem R.N.; Huusom, Jakob Kjøbsted; Gernaey, Krist V.

Year: 2024

Venue: Frontiers in Chemical Engineering

DOI: https://doi.org/10.3389/fceng.2024.1494244

Paper Hybrid modeling for biopharmaceutical processes: advantages, opportunities, and implementation

Narayanan, Harini; Stosch, Moritz von; Feidl, Fabian et al. · 2023 · Frontiers in Chemical Engineering · DOI

Full title: Hybrid modeling for biopharmaceutical processes: advantages, opportunities, and implementation

Authors: Narayanan, Harini; Stosch, Moritz von; Feidl, Fabian; Sokolov, Michael; Morbidelli, Massimo; Butté, Alessandro

Year: 2023

Venue: Frontiers in Chemical Engineering

DOI: https://doi.org/10.3389/fceng.2023.1157889

Paper Design ideas behind Bioprocess Library for Modelica

Axelsson, Jan Peter · 2024 · Linköping electronic conference proceedings · DOI

Full title: Design ideas behind Bioprocess Library for Modelica

Authors: Axelsson, Jan Peter

Year: 2024

Venue: Linköping electronic conference proceedings

DOI: https://doi.org/10.3384/ecp204453

Paper Cell clone selection-impact of operation modes and medium exchange strategies on clone ranking.

Dorn, Marie; Ferng, Christine; Klottrup-Rees, Kerensa et al. · 2024 · Frontiers in bioengineering and biotechnology · DOI

Full title: Cell clone selection-impact of operation modes and medium exchange strategies on clone ranking.

Authors: Dorn, Marie; Ferng, Christine; Klottrup-Rees, Kerensa; Lee, Kenneth; Micheletti, Martina

Year: 2024

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2024.1479633

Paper Boost dynamic protocols for producing mammalian biopharmaceuticals with intensified DoE—a practical guide to analyses with OLS and hybrid modeling

Nold, Verena; Junghans, Lisa; Bayer, Benjamin et al. · 2023 · Frontiers in Chemical Engineering · DOI

Full title: Boost dynamic protocols for producing mammalian biopharmaceuticals with intensified DoE—a practical guide to analyses with OLS and hybrid modeling

Authors: Nold, Verena; Junghans, Lisa; Bayer, Benjamin; Bisgen, Lorenzo; Duerkop, Mark; Drerup, Raphael; Presser, Beate; Schwab, Thomas; Bluhmki, Erich; Wieschalka, Stefan; Knapp, Bettina L.

Year: 2023

Venue: Frontiers in Chemical Engineering

DOI: https://doi.org/10.3389/fceng.2022.1044245

Paper Strategies Used in Manufacturing Processes to Drive and Control Mammalian Cells to Undergo a Lactate Metabolic Shift

Muralidharan, Naveenganesh; Bolduc, Emma; Davis, Mark · 2024 · Indian Journal of Pharmaceutical Sciences · DOI

Full title: Strategies Used in Manufacturing Processes to Drive and Control Mammalian Cells to Undergo a Lactate Metabolic Shift

Authors: Muralidharan, Naveenganesh; Bolduc, Emma; Davis, Mark

Year: 2024

Venue: Indian Journal of Pharmaceutical Sciences

DOI: https://doi.org/10.36468/pharmaceutical-sciences.129314

Paper Model-Based Design of Process Strategies for Cell Culture Bioprocesses: State of the Art and New Perspectives

Möller, Johannes; Pörtner, Ralf · 2017 · InTech eBooks · DOI

Full title: Model-Based Design of Process Strategies for Cell Culture Bioprocesses: State of the Art and New Perspectives

Authors: Möller, Johannes; Pörtner, Ralf

Year: 2017

Venue: InTech eBooks

DOI: https://doi.org/10.5772/67600

Paper Dynamic Optimization of Bioprocesses

Koumpouras, George; Kontoravdi, Cleo · 2012 · Applied Mathematics · DOI

Full title: Dynamic Optimization of Bioprocesses

Authors: Koumpouras, George; Kontoravdi, Cleo

Year: 2012

Venue: Applied Mathematics

DOI: https://doi.org/10.4236/am.2012.330208

Paper The Effect of Hyper-Osmotic Conditions on the Growth, Metabolism, and Specific Antibody Productivity of a GS-NS0 Cell Line

Brady, Stefanie Ellen · 2009 · Digital Repository at the University of Maryland (University of Maryland College Park)

Full title: The Effect of Hyper-Osmotic Conditions on the Growth, Metabolism, and Specific Antibody Productivity of a GS-NS0 Cell Line

Authors: Brady, Stefanie Ellen

Year: 2009

Venue: Digital Repository at the University of Maryland (University of Maryland College Park)

Paper A control strategy to investigate the relationship between specific productivity and high-mannose glycoforms in CHO cells

Zalai, Dénes; Hevér, Helga; Lovász, Krisztina et al. · 2016 · Applied Microbiology and Biotechnology · DOI

Full title: A control strategy to investigate the relationship between specific productivity and high-mannose glycoforms in CHO cells

Authors: Zalai, Dénes; Hevér, Helga; Lovász, Krisztina; Molnár, Dóra; Wechselberger, Patrick; Hofer, Alexandra; Párta, László; Putics, Ákos; Herwig, Christoph

Year: 2016

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-016-7380-4

Paper Metabolic characterization of a CHO cell size increase phase in fed-batch cultures

Pan, Xiao; Dalm, Ciska; Wijffels, René H. et al. · 2017 · Applied Microbiology and Biotechnology · DOI

Full title: Metabolic characterization of a CHO cell size increase phase in fed-batch cultures

Authors: Pan, Xiao; Dalm, Ciska; Wijffels, René H.; Martens, Dirk E.

Year: 2017

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-017-8531-y

Paper Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing

Esmonde‐White, Karen A.; Cuellar, Maryann; Uerpmann, Carsten et al. · 2016 · Analytical and Bioanalytical Chemistry · DOI

Full title: Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing

Authors: Esmonde‐White, Karen A.; Cuellar, Maryann; Uerpmann, Carsten; Lenain, Bruno; Lewis, Ian R.

Year: 2016

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-016-9824-1

Paper Single compound data supplementation to enhance transferability of fermentation specific Raman spectroscopy models

Klaverdijk, Maarten; Ottens, Marcel; Klijn, Marieke E. · 2025 · Analytical and Bioanalytical Chemistry · DOI

Full title: Single compound data supplementation to enhance transferability of fermentation specific Raman spectroscopy models

Authors: Klaverdijk, Maarten; Ottens, Marcel; Klijn, Marieke E.

Year: 2025

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-025-05768-5

Paper Applications of off-gas mass spectrometry in fed-batch mammalian cell culture

Goh, Hai‐Yuan; Sulu, Michael; Alosert, Haneen et al. · 2019 · Bioprocess and Biosystems Engineering · DOI

Full title: Applications of off-gas mass spectrometry in fed-batch mammalian cell culture

Authors: Goh, Hai‐Yuan; Sulu, Michael; Alosert, Haneen; Lewis, Graham; Josland, G.D.; Merriman, Daniel

Year: 2019

Venue: Bioprocess and Biosystems Engineering

DOI: https://doi.org/10.1007/s00449-019-02242-2

Paper Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors

Metze, Sabrina; Ruhl, S. F.; Greller, Gerhard et al. · 2019 · Bioprocess and Biosystems Engineering · DOI

Full title: Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors

Authors: Metze, Sabrina; Ruhl, S. F.; Greller, Gerhard; Grimm, C.; Scholz, Judith

Year: 2019

Venue: Bioprocess and Biosystems Engineering

DOI: https://doi.org/10.1007/s00449-019-02216-4

Paper Pre-stage perfusion and ultra-high seeding cell density in CHO fed-batch culture: a case study for process intensification guided by systems biotechnology

Stepper, Lisa; Filser, Florian Alois; Fischer, Simon et al. · 2020 · Bioprocess and Biosystems Engineering · DOI

Full title: Pre-stage perfusion and ultra-high seeding cell density in CHO fed-batch culture: a case study for process intensification guided by systems biotechnology

Authors: Stepper, Lisa; Filser, Florian Alois; Fischer, Simon; Schaub, Jochen; Gorr, Ingo H.; Voges, Raphael

Year: 2020

Venue: Bioprocess and Biosystems Engineering

DOI: https://doi.org/10.1007/s00449-020-02337-1

Paper Hyperosmolality in CHO cell culture: effects on the proteome

Romanova, Nadiya; Schelletter, Louise; Hoffrogge, Raimund et al. · 2022 · Applied Microbiology and Biotechnology · DOI

Full title: Hyperosmolality in CHO cell culture: effects on the proteome

Authors: Romanova, Nadiya; Schelletter, Louise; Hoffrogge, Raimund; Noll, Thomas

Year: 2022

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-022-11861-x

Paper Exploring metabolic effects of dipeptide feed media on CHO cell cultures by in silico model-guided flux analysis

Park, Seo‐Young; Song, Jinsung; Choi, Dong‐Hyuk et al. · 2024 · Applied Microbiology and Biotechnology · DOI

Full title: Exploring metabolic effects of dipeptide feed media on CHO cell cultures by in silico model-guided flux analysis

Authors: Park, Seo‐Young; Song, Jinsung; Choi, Dong‐Hyuk; Park, Uiseon; Cho, Hyeran; Hong, Bee Hak; Silberberg, Yaron; Lee, Dong‐Yup

Year: 2024

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-023-12997-0

Paper Exploring the limits of conventional small-scale CHO fed-batch for accelerated on demand monoclonal antibody production

Mahé, Amélie; Martiné, Alexandra; Fagète, Séverine et al. · 2021 · Bioprocess and Biosystems Engineering · DOI

Full title: Exploring the limits of conventional small-scale CHO fed-batch for accelerated on demand monoclonal antibody production

Authors: Mahé, Amélie; Martiné, Alexandra; Fagète, Séverine; Girod, Pierre‐Alain

Year: 2021

Venue: Bioprocess and Biosystems Engineering

DOI: https://doi.org/10.1007/s00449-021-02657-w

Paper A simple method to determine evaporation and compensate for liquid losses in small-scale cell culture systems

Wiegmann, Vincent; Martinez, Cristina Bernal; Baganz, Frank · 2018 · Biotechnology Letters · DOI

Full title: A simple method to determine evaporation and compensate for liquid losses in small-scale cell culture systems

Authors: Wiegmann, Vincent; Martinez, Cristina Bernal; Baganz, Frank

Year: 2018

Venue: Biotechnology Letters

DOI: https://doi.org/10.1007/s10529-018-2556-x

Paper Genome-scale modeling of Chinese hamster ovary cells by hybrid semi-parametric flux balance analysis

Ramos, João R. C.; Poiares‐Oliveira, Gil; Dumas, Patrick et al. · 2022 · Bioprocess and Biosystems Engineering · DOI

Full title: Genome-scale modeling of Chinese hamster ovary cells by hybrid semi-parametric flux balance analysis

Authors: Ramos, João R. C.; Poiares‐Oliveira, Gil; Dumas, Patrick; Oliveira, Rui

Year: 2022

Venue: Bioprocess and Biosystems Engineering

DOI: https://doi.org/10.1007/s00449-022-02795-9

Paper Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins

Wolnick, Nicolas; Dickson, Marissa; Webster, Thaddaeus A. et al. · 2024 · Bioprocess and Biosystems Engineering · DOI

Full title: Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins

Authors: Wolnick, Nicolas; Dickson, Marissa; Webster, Thaddaeus A.; Connolly, Roger P.; Fernandes, Nancy; Encheva, Vesela; Crittenden, Hunter; Hodgkins, Jessica; Hadley, Brian C.; Palermo, Gabriella; Hendrick, Shannon; Newell, Roy A.; Gray, Genevieve; Siltanen, Christian; Armstrong, Julia; Downey, Brandon; Mason, Carrie

Year: 2024

Venue: Bioprocess and Biosystems Engineering

DOI: https://doi.org/10.1007/s00449-024-02997-3

Paper Selection of chemically defined media for CHO cell fed-batch culture processes

Pan, Xiao; Streefland, Mathieu; Dalm, Ciska et al. · 2016 · Cytotechnology · DOI

Full title: Selection of chemically defined media for CHO cell fed-batch culture processes

Authors: Pan, Xiao; Streefland, Mathieu; Dalm, Ciska; Wijffels, René H.; Martens, Dirk E.

Year: 2016

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-016-0036-5

Paper Effects of process intensification on homogeneity of an IgG1:κ monoclonal antibody during perfusion culture

Liang, George H.; Madhavarao, Chikkathur N.; Morris, Caitlin et al. · 2024 · Applied Microbiology and Biotechnology · DOI

Full title: Effects of process intensification on homogeneity of an IgG1:κ monoclonal antibody during perfusion culture

Authors: Liang, George H.; Madhavarao, Chikkathur N.; Morris, Caitlin; O'Connor, T; Ashraf, Muhammad; Yoon, Seongkyu

Year: 2024

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-024-13110-9

Thesis Improvement of xylanase production by recombinant Escherichia coli DH5α using fed-batch fermentation

Basar, Bazilah · 2011 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Improvement of xylanase production by recombinant Escherichia coli DH5α using fed-batch fermentation

Authors: Basar, Bazilah

Year: 2011

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/27361/1/FBSB%202011%2047R.pdf

Thesis Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Zhang, Liang · 2020 · KTH Royal Institute of Technology · DOI

Full title: Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Authors: Zhang, Liang

Year: 2020

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-273343

Thesis Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production

Monsalve-Bravo, Gloria M; Garelli, Fabricio; Mozumder, Salatul Islam et al. · 2015 · National University of La Plata – SeDiCI · DOI

Full title: Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production

Authors: Monsalve-Bravo, Gloria M; Garelli, Fabricio; Mozumder, Salatul Islam; Alvarez, Hernan; De Battista, Hernán

Year: 2015

Venue: National University of La Plata – SeDiCI

DOI: http://sedici.unlp.edu.ar/handle/10915/134699

Thesis Global stabilisation of continuous bioreactors: tools for analysis and design of feeding laws

De Battista, Hernán; Jamilis Ricaldoni, Martín Ignacio; Garelli, Fabricio et al. · 2018 · National University of La Plata – SeDiCI · DOI

Full title: Global stabilisation of continuous bioreactors: tools for analysis and design of feeding laws

Authors: De Battista, Hernán; Jamilis Ricaldoni, Martín Ignacio; Garelli, Fabricio; Picó, Jesús

Year: 2018

Venue: National University of La Plata – SeDiCI

DOI: http://sedici.unlp.edu.ar/handle/10915/124891

Thesis Enhancement of Lipid Production in Rhodosporidium toruloides: Designing Feeding Strategies Through Dynamic Flux Balance Analysis

Castañeda, María Teresita; Nuñez, Sebastián; Jamilis Ricaldoni, Martín Ignacio et al. · 2025 · National University of La Plata – SeDiCI · DOI

Full title: Enhancement of Lipid Production in Rhodosporidium toruloides: Designing Feeding Strategies Through Dynamic Flux Balance Analysis

Authors: Castañeda, María Teresita; Nuñez, Sebastián; Jamilis Ricaldoni, Martín Ignacio; De Battista, Hernán

Year: 2025

Venue: National University of La Plata – SeDiCI

DOI: http://sedici.unlp.edu.ar/handle/10915/189167

Thesis Reaction rate reconstruction from biomass concentration measurement in bioreactors using modified second-order sliding mode algorithms

De Battista, Hernán; Picó, Jesús; Garelli, Fabricio et al. · 2012 · National University of La Plata – SeDiCI · DOI

Full title: Reaction rate reconstruction from biomass concentration measurement in bioreactors using modified second-order sliding mode algorithms

Authors: De Battista, Hernán; Picó, Jesús; Garelli, Fabricio; Navarro, J. L.

Year: 2012

Venue: National University of La Plata – SeDiCI

DOI: http://sedici.unlp.edu.ar/handle/10915/123847

Thesis Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Murayyan, Abdulmonem · 2013 · University of Guelph · DOI

Full title: Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Authors: Murayyan, Abdulmonem

Year: 2013

Venue: University of Guelph

DOI: http://hdl.handle.net/10214/6604

Thesis Macroscopic models of Chinese hamster ovary cell cultures

Hagrot, Erika · 2019 · KTH Royal Institute of Technology · DOI

Full title: Macroscopic models of Chinese hamster ovary cell cultures

Authors: Hagrot, Erika

Year: 2019

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-262850

Thesis Optical in-line biosensor for long-term continuous glucose monitoring and control in cell culture

Tric, Mircea · 2017 · Heidelberg University · DOI

Full title: Optical in-line biosensor for long-term continuous glucose monitoring and control in cell culture

Authors: Tric, Mircea

Year: 2017

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/23763/1/Dissertation%20Mircea%20Tric.pdf

Thesis The Assessment of MAb Quality and Quantity

Drouillard, Gerald · 2015 · University of Guelph · DOI

Full title: The Assessment of MAb Quality and Quantity

Authors: Drouillard, Gerald

Year: 2015

Venue: University of Guelph

DOI: http://hdl.handle.net/10214/8743

Thesis Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022 · KTH Royal Institute of Technology · DOI

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

Year: 2022

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Hong, Moo Sun · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Authors: Hong, Moo Sun

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/138943

Thesis Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Maloney, Andrew John · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Authors: Maloney, Andrew John

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/158315

Thesis Recycling and Regeneration of Spent Perfusion Media via Ion Concentration Polarization

Wynne, Eric Michael · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Recycling and Regeneration of Spent Perfusion Media via Ion Concentration Polarization

Authors: Wynne, Eric Michael

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/164151

Thesis Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays

Rohskopf, Zhumei · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays

Authors: Rohskopf, Zhumei

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/152457

Thesis Characterization of the down regulation of antibody production in high cell density perfusion culture

Morrill, Joyce Catherine · 2006 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Characterization of the down regulation of antibody production in high cell density perfusion culture

Authors: Morrill, Joyce Catherine

Year: 2006

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/32602

Thesis Modeling, simulation and dynamic otpimization applied to an ethanol fed-batch fermentation process

Siqueira, Adriano Almeida Gonçalves · 2013 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Modeling, simulation and dynamic otpimization applied to an ethanol fed-batch fermentation process

Authors: Siqueira, Adriano Almeida Gonçalves

Year: 2013

Venue: Universidade de São Paulo – USP Digital Library

DOI: http://abcm.org.br/anais/cobem/2013/PDF/2058.pdf

Thesis Enhancing mammalian bioprocessing through engineering Chinese hamster ovary cell metabolism

Hefzi, Hooman · 2018 · University of California, San Diego (UCSD) · DOI

Full title: Enhancing mammalian bioprocessing through engineering Chinese hamster ovary cell metabolism

Authors: Hefzi, Hooman

Year: 2018

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/91h2z79t

Thesis The influence of glucose metabolism on high cell density fermentation /

Luli, Gregory William · 1988 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: The influence of glucose metabolism on high cell density fermentation /

Authors: Luli, Gregory William

Year: 1988

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1487594970651618

Thesis Engineering Oxidative Stress Resistance in CHO Cell Factories

Fairbrass, Danielle L · 2016 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Engineering Oxidative Stress Resistance in CHO Cell Factories

Authors: Fairbrass, Danielle L

Year: 2016

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/16227/1/Master_Copy_DLFairbrassThesis.pdf

Thesis Quantitative Analysis of Proteome Dynamics in Chinese Hamster Ovary cells

Florczak, Beata D · 2019 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Quantitative Analysis of Proteome Dynamics in Chinese Hamster Ovary cells

Authors: Florczak, Beata D

Year: 2019

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/25823/1/B.Florczak_thesis.pdf

Thesis Evaluation and characterisation of phenotypic heterogeneity in Chinese Hamster Ovary cell populations during long-term culture

Fernandez Martell, Alejandro · 2015 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Evaluation and characterisation of phenotypic heterogeneity in Chinese Hamster Ovary cell populations during long-term culture

Authors: Fernandez Martell, Alejandro

Year: 2015

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/9152/7/PhD%20thesis%20Alejandro%20Fernandez%20Martell%20%28final%20version%29.pdf

Thesis Development of an integrated platform for the production of recombinant biopharmaceuticals

Segarra, Camille · 2013 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Development of an integrated platform for the production of recombinant biopharmaceuticals

Authors: Segarra, Camille

Year: 2013

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/4147/1/Segarra_Thesis_PostCorrections.pdf

Thesis Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

Zagari, Francesca · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

Authors: Zagari, Francesca

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/84627

Thesis Influence of cell-line and process conditions on the glycosylation of recombinant proteins

Nahrgang, Stefan · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Influence of cell-line and process conditions on the glycosylation of recombinant proteins

Authors: Nahrgang, Stefan

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/211632

Thesis ELUCIDATING MAMMALIAN CELL METABOLISM USING ‘OMICS TO ENHANCE BIOPROCESS CAPABILITIES

Dhara, Venkata Gayatri · 2022 · Johns Hopkins University · DOI

Full title: ELUCIDATING MAMMALIAN CELL METABOLISM USING ‘OMICS TO ENHANCE BIOPROCESS CAPABILITIES

Authors: Dhara, Venkata Gayatri

Year: 2022

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/66775

Thesis Predictive models for upstream mammalian cell culture development: a review

Yatipanthalawa, BS; Gras, SL · 2023 · University of Melbourne · DOI

Full title: Predictive models for upstream mammalian cell culture development: a review

Authors: Yatipanthalawa, BS; Gras, SL

Year: 2023

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/339523

Thesis Extremum-Seeking Control of Industrial-Scale Fermentation Processes

Johnsson, Ola · 2013 · Lund University (LUP) · DOI

Full title: Extremum-Seeking Control of Industrial-Scale Fermentation Processes

Authors: Johnsson, Ola

Year: 2013

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/4065043

Thesis Probing Control : Analysis and Design with Application to Fed-Batch Bioreactors

Velut, Stéphane · 2005 · Lund University (LUP) · DOI

Full title: Probing Control : Analysis and Design with Application to Fed-Batch Bioreactors

Authors: Velut, Stéphane

Year: 2005

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/24605

Thesis Probing Control in B. licheniformis Fermentations

Johnsson, Ola · 2010 · Lund University Student Papers · DOI

Full title: Probing Control in B. licheniformis Fermentations

Authors: Johnsson, Ola

Year: 2010

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/8847429

Thesis Probing Control of Glucose Feeding in Escherichia coli Cultivations

Åkesson, Mats · 1999 · Lund University (LUP) · DOI

Full title: Probing Control of Glucose Feeding in Escherichia coli Cultivations

Authors: Åkesson, Mats

Year: 1999

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/40163

Thesis Impact de la modification du métabolisme primaire des cellules CHO sur leur productivité

Toussaint, Cecile · 2017 · Université de Montréal (Papyrus) · DOI

Full title: Impact de la modification du métabolisme primaire des cellules CHO sur leur productivité

Authors: Toussaint, Cecile

Year: 2017

Venue: Université de Montréal (Papyrus)

DOI: http://hdl.handle.net/1866/18549

Thesis Recombinant protein production utilising a metallothionein expression system and a Super-CHO cell line

Huang, Edwin P.C. · 2006 · UNSW Sydney · DOI

Full title: Recombinant protein production utilising a metallothionein expression system and a Super-CHO cell line

Authors: Huang, Edwin P.C.

Year: 2006

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/24940

Thesis High cell density mammalian cell fermentation

Jirasripongpun, Kalyanee · 1992 · UNSW Sydney · DOI

Full title: High cell density mammalian cell fermentation

Authors: Jirasripongpun, Kalyanee

Year: 1992

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/68130

Thesis Appendix for: "Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch"

Gangadharan, Nishanthi · 2023 · University of Cambridge · DOI

Full title: Appendix for: "Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch"

Authors: Gangadharan, Nishanthi

Year: 2023

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/347248

Thesis The Biological Impact of High Throughput Continuous Bioprocessing

Sewell, David John · 2020 · University of Cambridge · DOI

Full title: The Biological Impact of High Throughput Continuous Bioprocessing

Authors: Sewell, David John

Year: 2020

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/311711

Thesis Study and characterisation of human HEK293 cell line as a platform for recombinant protein production

Liste Calleja, Leticia · 2015 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Study and characterisation of human HEK293 cell line as a platform for recombinant protein production

Authors: Liste Calleja, Leticia

Year: 2015

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/308324

Thesis Effect of adenosine and cordycepin on recombinant antibody production yields in two different Chinease hamster ovary cell lines

Jarusintanakorn, Salinthip; Rangnoi, Kuntalee; Yamabhai, Montarop et al. · 2024 · Utrecht University · DOI

Full title: Effect of adenosine and cordycepin on recombinant antibody production yields in two different Chinease hamster ovary cell lines

Authors: Jarusintanakorn, Salinthip; Rangnoi, Kuntalee; Yamabhai, Montarop; Mastrobattista, Enrico

Year: 2024

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/438035

Thesis Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe et al. · 2016 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

Authors: López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe; Carrillo-Cocom, Leydi Maribel; Rocha-Pizaña, María del Refugio; Alvarez, Mario Moises

Year: 2016

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/105504

Thesis Development of a protein-free fed-batch process for NS0 cells: studies on regulation of proliferation

Spens, Erika · 2006 · KTH Royal Institute of Technology · DOI

Full title: Development of a protein-free fed-batch process for NS0 cells: studies on regulation of proliferation

Authors: Spens, Erika

Year: 2006

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4162

Thesis Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

Sumit, Madhuresh; Dolatshahi, Sepideh; Chu, An-Hsiang Adam et al. · 2020 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

Authors: Sumit, Madhuresh; Dolatshahi, Sepideh; Chu, An-Hsiang Adam; Cote, Kaffa; Scarcelli, John J.; Marshall, Jeffrey K.; Cornell, Richard J.; Weiss, Ron; Lauffenburger, Douglas A.; Mulukutla, Bhanu Chandra; Figueroa, Bruno

Year: 2020

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/125974

Thesis Continuous Online Protein Quality Monitoring during Perfusion Culture Production Using an Integrated Micro/Nanofluidic System

Kwon, Taehong; Ko, Sung Hee; Hamel, Jean-Francois P et al. · 2020 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Continuous Online Protein Quality Monitoring during Perfusion Culture Production Using an Integrated Micro/Nanofluidic System

Authors: Kwon, Taehong; Ko, Sung Hee; Hamel, Jean-Francois P; Han, Jongyoon

Year: 2020

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/125538

Thesis Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76323

Thesis Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells

Davami, Fatemeh; Baldi, Lucia; Rajendra, Yashas et al. · 2014 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells

Authors: Davami, Fatemeh; Baldi, Lucia; Rajendra, Yashas; M Wurm, Florian

Year: 2014

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/108905

Thesis An Optimal Operating Strategy for Fed-Batch Fermentations by Feeding the Overflow Metabolite

Valentinotti, S.; Cannizzaro, C.; Srinivasan, B. et al. · 2004 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: An Optimal Operating Strategy for Fed-Batch Fermentations by Feeding the Overflow Metabolite

Authors: Valentinotti, S.; Cannizzaro, C.; Srinivasan, B.; Bonvin, D.

Year: 2004

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/176669

Thesis Optimal Control of Fed-Batch Fermenters

Valentinotti, S.; Cannizzaro, C.; Rhiel, M. et al. · 2004 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Optimal Control of Fed-Batch Fermenters

Authors: Valentinotti, S.; Cannizzaro, C.; Rhiel, M.; Holmberg, U.; von Stockar, U.; Bonvin, D.

Year: 2004

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/175476

Thesis Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells

Meuwly, F.; von Stockar, U.; Kadouri, A. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells

Authors: Meuwly, F.; von Stockar, U.; Kadouri, A.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226104

Thesis Evaluation of an online biomass probe to monitor cell growth and cell death.

Perani, A; Gloria, B; Wang, D et al. · 2022 · University of Melbourne · DOI

Full title: Evaluation of an online biomass probe to monitor cell growth and cell death.

Authors: Perani, A; Gloria, B; Wang, D; Buffier, A-S; Berteau, O; Esteban, G; Smyth, FE; Scott, AM

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/303929

Thesis Impact on product quality of high productive GS-CHO cell lines.

Perani, A; Gloria, B; Wang, D et al. · 2022 · University of Melbourne · DOI

Full title: Impact on product quality of high productive GS-CHO cell lines.

Authors: Perani, A; Gloria, B; Wang, D; Murphy, R; Singh, HK; Smyth, FE; Scott, AM

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/303930

Thesis Biomass soft sensor for a Pichia pastoris fed‐batch process based on phase detection and hybrid modeling

Brunner, Vincent; Siegl, Manuel; Geier, Dominik et al. · 2020 · Technical University of Munich (TUM) · DOI

Full title: Biomass soft sensor for a Pichia pastoris fed‐batch process based on phase detection and hybrid modeling

Authors: Brunner, Vincent;Siegl, Manuel;Geier, Dominik;Becker, Thomas

Year: 2020

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1576014

Thesis High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

Zhang, Ye · 2017 · KTH Royal Institute of Technology · DOI

Full title: High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

Authors: Zhang, Ye

Year: 2017

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-207600

Thesis Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.

Traustason, Bergthor; Cheeks, Matthew; Dikicioglu, Duygu · 2020 · University of Cambridge · DOI

Full title: Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.

Authors: Traustason, Bergthor; Cheeks, Matthew; Dikicioglu, Duygu

Year: 2020

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/301284

Thesis Preemptive variation reduction in biologic drug substance manufacturing

Güereca Valdivia, Ismael · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Preemptive variation reduction in biologic drug substance manufacturing

Authors: Güereca Valdivia, Ismael

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/155982

Thesis Probing Control of Glucose Feeding in Cultivation of Saccharomyces cerevisiae

Fredriksson, John · 2001 · Lund University Student Papers · DOI

Full title: Probing Control of Glucose Feeding in Cultivation of Saccharomyces cerevisiae

Authors: Fredriksson, John

Year: 2001

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/8848220

Thesis Development of tools for monitoring and controlling cell cultures through the metabolic analysis

Martínez Monge, Iván · 2018 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Development of tools for monitoring and controlling cell cultures through the metabolic analysis

Authors: Martínez Monge, Iván

Year: 2018

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/664350

Thesis Increasing biomass production in bioreactors applying metabolic analysis and engineering tools

Comas Sanchez, Pere · 2021 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Increasing biomass production in bioreactors applying metabolic analysis and engineering tools

Authors: Comas Sanchez, Pere

Year: 2021

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/671074

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Paper Towards in situ continuous feeding via controlled release of complete nutrients for fed-batch culture of animal cells

Jyoti Rawat; M. Gadgil · 2020 · Biochemical Engineering Journal · DOI

Full title: Towards in situ continuous feeding via controlled release of complete nutrients for fed-batch culture of animal cells

Authors: Jyoti Rawat; M. Gadgil

Year: 2020

Venue: Biochemical Engineering Journal

DOI: https://doi.org/10.1016/j.bej.2019.107436

Paper A Multi Clone Kinetic Model for characterizing Chinese hamster ovary cell line variability

Sietaram, Devi; Kotidis, Pavlos; Finka, Gary et al. · 2024 · Journal of Industrial Microbiology & Biotechnology · DOI

Full title: A Multi Clone Kinetic Model for characterizing Chinese hamster ovary cell line variability

Authors: Sietaram, Devi; Kotidis, Pavlos; Finka, Gary; Lapkin, Alexei A.

Year: 2024

Venue: Journal of Industrial Microbiology & Biotechnology

DOI: https://doi.org/10.1093/jimb/kuaf029

Paper Optimal design of dynamic experiments for scalar-on-function linear models with application to a biopharmaceutical study

Michaelides, Damianos; Adamou, Maria; Woods, David C. et al. · 2026 · Biometrics · DOI

Full title: Optimal design of dynamic experiments for scalar-on-function linear models with application to a biopharmaceutical study

Authors: Michaelides, Damianos; Adamou, Maria; Woods, David C.; Overstall, Antony M.

Year: 2026

Venue: Biometrics

DOI: https://doi.org/10.1093/biomtc/ujaf169

Paper Comparing Kinetic versus Stoichiometric Priorities in Hybrid Models of CHO Metabolism

Khare, Pratik; Ndahiro, Nelson; Klaubert, Stephanie R. et al. · 2025 · DOI

Full title: Comparing Kinetic versus Stoichiometric Priorities in Hybrid Models of CHO Metabolism

Authors: Khare, Pratik; Ndahiro, Nelson; Klaubert, Stephanie R.; Ma, Edward; Bertalan, Tom; Kevrekidis, Ioannis G.; Harcum, Sarah W.; Betenbaugh, Michael J.

Year: 2025

DOI: https://doi.org/10.1101/2025.10.28.685134

Paper Development of Raman Calibration Model Without Culture Data for In-Line Analysis of Metabolites in Cell Culture Media

Hara, Risa; Kobayashi, Wataru; Yamanaka, Hiroaki et al. · 2023 · Applied Spectroscopy · DOI

Full title: Development of Raman Calibration Model Without Culture Data for In-Line Analysis of Metabolites in Cell Culture Media

Authors: Hara, Risa; Kobayashi, Wataru; Yamanaka, Hiroaki; Murayama, Kodai; Shimoda, Soichiro; Ozaki, Yukihiro

Year: 2023

Venue: Applied Spectroscopy

DOI: https://doi.org/10.1177/00037028231160197

Paper FACTORS AFFECTING CHINESE HAMSTER OVARY CELL PROLIFERATION AND VIABILITY

Reķēna, Alīna; Livkisa, Dora; Loča, Dagnija · 2019 · Environment Technology Resources Proceedings of the International Scientific and Practical Conference · DOI

Full title: FACTORS AFFECTING CHINESE HAMSTER OVARY CELL PROLIFERATION AND VIABILITY

Authors: Reķēna, Alīna; Livkisa, Dora; Loča, Dagnija

Year: 2019

Venue: Environment Technology Resources Proceedings of the International Scientific and Practical Conference

DOI: https://doi.org/10.17770/etr2019vol1.4106

Paper Amino acid metabolism in Chinese hamster ovary cell culture

Kyriakopoulos, Sarantos · 2014 · Spiral (Imperial College London) · DOI

Full title: Amino acid metabolism in Chinese hamster ovary cell culture

Authors: Kyriakopoulos, Sarantos

Year: 2014

Venue: Spiral (Imperial College London)

DOI: https://doi.org/10.25560/25143

Paper Application of Hybrid Neural Models to Bioprocesses: A Systematic Literature Review

Agharafeie, Roshanak; Oliveira, Rui; Ramos, João R. C. et al. · 2023 · DOI

Full title: Application of Hybrid Neural Models to Bioprocesses: A Systematic Literature Review

Authors: Agharafeie, Roshanak; Oliveira, Rui; Ramos, João R. C.; Mendes, Jorge M.

Year: 2023

DOI: https://doi.org/10.22541/au.167465887.70993839/v2

Paper Using MVDA with Stoichiometric Balances to Optimize Amino Acid Concentrations in Chemically Defined CHO Cell Culture Medium for Improved Culture Performance

Salim, Taha; Chauhan, Gaurav; Templeton, Neil et al. · 2021 · DOI

Full title: Using MVDA with Stoichiometric Balances to Optimize Amino Acid Concentrations in Chemically Defined CHO Cell Culture Medium for Improved Culture Performance

Authors: Salim, Taha; Chauhan, Gaurav; Templeton, Neil; Ling, Wai Lam W.

Year: 2021

DOI: https://doi.org/10.22541/au.162573443.36020543/v1

Paper In situ FRET Biosensors for the in vivo measurement of important metabolites during cell culture

Behjousiar, Alireza · 2014 · Spiral (Imperial College London) · DOI

Full title: In situ FRET Biosensors for the in vivo measurement of important metabolites during cell culture

Authors: Behjousiar, Alireza

Year: 2014

Venue: Spiral (Imperial College London)

DOI: https://doi.org/10.25560/24852

Paper Estimating Extrinsic Dyes for Fluorometric Online Monitoring of Antibody Aggregation in CHO Fed-Batch Cultivations

Schwab, Karen; Hesse, Friedemann · 2017 · Bioengineering · DOI

Full title: Estimating Extrinsic Dyes for Fluorometric Online Monitoring of Antibody Aggregation in CHO Fed-Batch Cultivations

Authors: Schwab, Karen; Hesse, Friedemann

Year: 2017

Venue: Bioengineering

DOI: https://doi.org/10.3390/bioengineering4030065

Paper Deciphering Metabolic Pathways in High Seeding Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective

Bokelmann, Carolin; Ehsani, Alireza; Schaub, Jochen et al. · 2024 · Preprints.org · DOI

Full title: Deciphering Metabolic Pathways in High Seeding Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective

Authors: Bokelmann, Carolin; Ehsani, Alireza; Schaub, Jochen; Stiefel, Fabian

Year: 2024

Venue: Preprints.org

DOI: https://doi.org/10.20944/preprints202402.1474.v1

Paper Continuous Feeding Reduces the Generation of Metabolic Byproducts and Increases Antibodies Expression in Chinese Hamster Ovary-K1 Cells.

Xiao, Shang; Ahmed, Waqas; Mohsin, Ali et al. · 2021 · Life (Basel, Switzerland) · DOI

Full title: Continuous Feeding Reduces the Generation of Metabolic Byproducts and Increases Antibodies Expression in Chinese Hamster Ovary-K1 Cells.

Authors: Xiao, Shang; Ahmed, Waqas; Mohsin, Ali; Guo, Meijin

Year: 2021

Venue: Life (Basel, Switzerland)

DOI: https://doi.org/10.3390/life11090945

Paper A Metabolomics Approach to Increasing Chinese Hamster Ovary (CHO) Cell Productivity

Yao, Grace; Aron, Kathryn; Borys, Michael et al. · 2021 · Metabolites · DOI

Full title: A Metabolomics Approach to Increasing Chinese Hamster Ovary (CHO) Cell Productivity

Authors: Yao, Grace; Aron, Kathryn; Borys, Michael; Li, Zheng Jian; Pendse, Girish; Lee, Kyongbum

Year: 2021

Venue: Metabolites

DOI: https://doi.org/10.3390/metabo11120823

Paper Scaling Fed-Batch and Perfusion Antibody Production Processes in Geometrically Dissimilar Stirred Bioreactors

Ott, Vivian; Ott, Jan; Eibl, Dieter et al. · 2024 · Processes · DOI

Full title: Scaling Fed-Batch and Perfusion Antibody Production Processes in Geometrically Dissimilar Stirred Bioreactors

Authors: Ott, Vivian; Ott, Jan; Eibl, Dieter; Eibl, Regine

Year: 2024

Venue: Processes

DOI: https://doi.org/10.3390/pr12040806

Paper 3D Printed, Single-Use Bioreactor with Integrated Inline Sensors for Microbial and Mammalian Cell Cultivation—A Case Study

Schneider, Samuel; Seidel, Stefan; Seefeldt, Andressa et al. · 2023 · Processes · DOI

Full title: 3D Printed, Single-Use Bioreactor with Integrated Inline Sensors for Microbial and Mammalian Cell Cultivation—A Case Study

Authors: Schneider, Samuel; Seidel, Stefan; Seefeldt, Andressa; Romang, Michael; Kastl, Simon; Gensel, Julia; Neumeyer, Thomas; John, Gernot T.; Eibl, Dieter

Year: 2023

Venue: Processes

DOI: https://doi.org/10.3390/pr11113231

Paper Towards Autonomous Process Control—Digital Twin for CHO Cell-Based Antibody Manufacturing Using a Dynamic Metabolic Model

Helgers, Heribert; Schmidt, A.; Strube, Jochen · 2022 · Processes · DOI

Full title: Towards Autonomous Process Control—Digital Twin for CHO Cell-Based Antibody Manufacturing Using a Dynamic Metabolic Model

Authors: Helgers, Heribert; Schmidt, A.; Strube, Jochen

Year: 2022

Venue: Processes

DOI: https://doi.org/10.3390/pr10020316

Paper Accelerating Biologics Manufacturing by Upstream Process Modelling

Kornecki, Martin; Strube, Jochen · 2019 · Processes · DOI

Full title: Accelerating Biologics Manufacturing by Upstream Process Modelling

Authors: Kornecki, Martin; Strube, Jochen

Year: 2019

Venue: Processes

DOI: https://doi.org/10.3390/pr7030166

Paper Accelerating Biomanufacturing by Modeling of Continuous Bioprocessing—Piloting Case Study of Monoclonal Antibody Manufacturing

Kornecki, Martin; Schmidt, A.; Lohmann, Lara Julia et al. · 2019 · Processes · DOI

Full title: Accelerating Biomanufacturing by Modeling of Continuous Bioprocessing—Piloting Case Study of Monoclonal Antibody Manufacturing

Authors: Kornecki, Martin; Schmidt, A.; Lohmann, Lara Julia; Huter, Maximilian Johannes; Mestmäcker, Fabian; Klepzig, L.; Mouellef, Mourad; Zobel‐Roos, Steffen; Strube, Jochen

Year: 2019

Venue: Processes

DOI: https://doi.org/10.3390/pr7080495

Paper Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors

Graf, Alexander; Woodhams, Angus; Nelson, Michael C. et al. · 2022 · Sensors · DOI

Full title: Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors

Authors: Graf, Alexander; Woodhams, Angus; Nelson, Michael C.; Richardson, Douglas D.; Short, Steven M.; Brower, Mark; Hoehse, Marek

Year: 2022

Venue: Sensors

DOI: https://doi.org/10.3390/s22093397

Paper Dielectric Spectroscopy and Optical Density Measurement for the Online Monitoring and Control of Recombinant Protein Production in Stably Transformed Drosophila melanogaster S2 Cells

Zitzmann, Jan; Weidner, Tobias; Eichner, Gerrit et al. · 2018 · Sensors · DOI

Full title: Dielectric Spectroscopy and Optical Density Measurement for the Online Monitoring and Control of Recombinant Protein Production in Stably Transformed Drosophila melanogaster S2 Cells

Authors: Zitzmann, Jan; Weidner, Tobias; Eichner, Gerrit; Salzig, Denise; Czermak, Peter

Year: 2018

Venue: Sensors

DOI: https://doi.org/10.3390/s18030900

Paper Intensified Influenza Virus Production in Suspension HEK293SF Cell Cultures Operated in Fed-Batch or Perfusion with Continuous Harvest

Silva, Cristina A. T.; Kamen, Amine; Henry, Olivier · 2023 · Vaccines · DOI

Full title: Intensified Influenza Virus Production in Suspension HEK293SF Cell Cultures Operated in Fed-Batch or Perfusion with Continuous Harvest

Authors: Silva, Cristina A. T.; Kamen, Amine; Henry, Olivier

Year: 2023

Venue: Vaccines

DOI: https://doi.org/10.3390/vaccines11121819

Paper Evaluation of microwell based systems and miniature bioreactors for rapid cell culture bioprocess development and scale-up

M. Sani · 2015 · UCL Discovery (University College London)

Full title: Evaluation of microwell based systems and miniature bioreactors for rapid cell culture bioprocess development and scale-up

Authors: M. Sani

Year: 2015

Venue: UCL Discovery (University College London)

Paper NOISE AWARE BAYESIAN PARAMETER ESTIMATION IN BIOPROCESSES

Lauren, Weir, · 2024 · MacSphere (McMaster University)

Full title: NOISE AWARE BAYESIAN PARAMETER ESTIMATION IN BIOPROCESSES

Authors: Lauren, Weir,

Year: 2024

Venue: MacSphere (McMaster University)

Paper Transcriptomic profiling as a tool to characterize CHO cell processes

Sayyari, Abdulaziz Abdullah Al · 2018 · DOI

Full title: Transcriptomic profiling as a tool to characterize CHO cell processes

Authors: Sayyari, Abdulaziz Abdullah Al

Year: 2018

DOI: https://doi.org/10.18174/460722

Paper Equal mixing time enables scale-down and optimization of a CHO cell culture process using a shaken microbioreactor system.

Wiegmann, Vincent; Gardner, Richard A; Spencer, Daniel I R et al. · 2021 · Biotechnology journal · DOI

Full title: Equal mixing time enables scale-down and optimization of a CHO cell culture process using a shaken microbioreactor system.

Authors: Wiegmann, Vincent; Gardner, Richard A; Spencer, Daniel I R; Baganz, Frank

Year: 2021

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202100360

Paper Debottlenecking and reformulating feed media for improved CHO cell growth and titer by data‐driven and model‐guided analyses

Park, Seo‐Young; Choi, Dong‐Hyuk; Song, Jinsung et al. · 2023 · Biotechnology Journal · DOI

Full title: Debottlenecking and reformulating feed media for improved CHO cell growth and titer by data‐driven and model‐guided analyses

Authors: Park, Seo‐Young; Choi, Dong‐Hyuk; Song, Jinsung; Park, Uiseon; Cho, Hyeran; Hong, Bee Hak; Silberberg, Yaron; Lee, Dong‐Yup

Year: 2023

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202300126

Paper On‐Line Control of Glucose Concentration in High‐Yielding Mammalian Cell Cultures Enabled Through Oxygen Transfer Rate Measurements

Goldrick, Stephen; Lee, Kenneth; Spencer, Christopher et al. · 2017 · Biotechnology Journal · DOI

Full title: On‐Line Control of Glucose Concentration in High‐Yielding Mammalian Cell Cultures Enabled Through Oxygen Transfer Rate Measurements

Authors: Goldrick, Stephen; Lee, Kenneth; Spencer, Christopher; Holmes, William R.; Kuiper, Marcel; Turner, Richard; Farid, Suzanne S.

Year: 2017

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.201700607

Paper Continuous optical in‐line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency while maintaining darbepoetin alfa product quality

Lederle, Mario; Tric, Mircea; Roth, Tatjana et al. · 2021 · Biotechnology Journal · DOI

Full title: Continuous optical in‐line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency while maintaining darbepoetin alfa product quality

Authors: Lederle, Mario; Tric, Mircea; Roth, Tatjana; Schütte, Lina; Rattenholl, Anke; Lütkemeyer, Dirk; Wölfl, Stefan; Werner, Tobias; Wiedemann, Philipp

Year: 2021

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202100088

Paper Noise aware parameter estimation in bioprocesses: Using neural network surrogate models with nonuniform data sampling

Weir, Lauren; Mathias, Nigel; Corbett, Brandon et al. · 2024 · AIChE Journal · DOI

Full title: Noise aware parameter estimation in bioprocesses: Using neural network surrogate models with nonuniform data sampling

Authors: Weir, Lauren; Mathias, Nigel; Corbett, Brandon; Mhaskar, Prashant

Year: 2024

Venue: AIChE Journal

DOI: https://doi.org/10.1002/aic.18634

Paper Process intensification to produce a difficult‐to‐express therapeutic enzyme by high cell density perfusion or enhanced fed‐batch

Särnlund, Sigrid; Jiang, Yun; Chotteau, Véronique · 2021 · Biotechnology and Bioengineering · DOI

Full title: Process intensification to produce a difficult‐to‐express therapeutic enzyme by high cell density perfusion or enhanced fed‐batch

Authors: Särnlund, Sigrid; Jiang, Yun; Chotteau, Véronique

Year: 2021

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27806

Paper Segmented linear modeling of CHO fed‐batch culture and its application to large scale production

Yahia, Bassem Ben; Gourévitch, Boris; Malphettes, Laetitia et al. · 2016 · Biotechnology and Bioengineering · DOI

Full title: Segmented linear modeling of CHO fed‐batch culture and its application to large scale production

Authors: Yahia, Bassem Ben; Gourévitch, Boris; Malphettes, Laetitia; Heinzle, Elmar

Year: 2016

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.26214

Paper Raman‐controlled pyruvate feeding to control metabolic activity and product quality in continuous biomanufacturing

Romann, Patrick; Schneider, Sebastian; Tobler, Daniela et al. · 2023 · Biotechnology Journal · DOI

Full title: Raman‐controlled pyruvate feeding to control metabolic activity and product quality in continuous biomanufacturing

Authors: Romann, Patrick; Schneider, Sebastian; Tobler, Daniela; Jordan, Martin; Périlleux, Arnaud; Souquet, Jonathan; Herwig, Christoph; Bielser, Jean‐Marc; Villiger, Thomas K.

Year: 2023

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202300318

Paper “Organized stress” for robust scale‐up of intensified production process with fed‐batch seed bioreactor

Yahia, Bassem Ben; Piednoir, Antoine; Dahomais, Thomas et al. · 2023 · Biotechnology and Bioengineering · DOI

Full title: “Organized stress” for robust scale‐up of intensified production process with fed‐batch seed bioreactor

Authors: Yahia, Bassem Ben; Piednoir, Antoine; Dahomais, Thomas; Eggermont, Stefanie; Paul, Wolfgang

Year: 2023

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28396

Paper Application of metabolic modeling for targeted optimization of high seeding density processes

Brunner, Matthias; Kolb, Klara; Keitel, Alena et al. · 2021 · Biotechnology and Bioengineering · DOI

Full title: Application of metabolic modeling for targeted optimization of high seeding density processes

Authors: Brunner, Matthias; Kolb, Klara; Keitel, Alena; Stiefel, Fabian; Wucherpfennig, Thomas; Bechmann, Jan; Unsoeld, Andreas; Schaub, Jochen

Year: 2021

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27693

Paper Controlling glycation of recombinant antibody in fed‐batch cell cultures

Yuk, Inn H.; Zhang, Boyan; Yang, Yi et al. · 2011 · Biotechnology and Bioengineering · DOI

Full title: Controlling glycation of recombinant antibody in fed‐batch cell cultures

Authors: Yuk, Inn H.; Zhang, Boyan; Yang, Yi; Dutina, George; Leach, Kimberly; Vijayasankaran, Natarajan; Shen, Amy; Andersen, Dana C.; Snedecor, Bradley; Joly, John C.

Year: 2011

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.23218

Paper Real‐time amino acid and glucose monitoring system for the automatic control of nutrient feeding in CHO cell culture using Raman spectroscopy

Domján, Júlia; Pantea, Eszter; Gyürkés, Martin et al. · 2022 · Biotechnology Journal · DOI

Full title: Real‐time amino acid and glucose monitoring system for the automatic control of nutrient feeding in CHO cell culture using Raman spectroscopy

Authors: Domján, Júlia; Pantea, Eszter; Gyürkés, Martin; Madarász, Lajos; Kozák, Dóra; Farkas, Attila; Horváth, Balázs; Benkő, Zsuzsa; Nagy, Zsombor Kristóf; Marosi, György; Hirsch, Edit

Year: 2022

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202100395

Paper Biomass specific perfusion rate as a control lever for the continuous manufacturing of biosimilar monoclonal antibodies from CHO cell cultures

Leong, Jiayu; Tang, Wen Qin; Chng, Jake et al. · 2024 · Biotechnology Journal · DOI

Full title: Biomass specific perfusion rate as a control lever for the continuous manufacturing of biosimilar monoclonal antibodies from CHO cell cultures

Authors: Leong, Jiayu; Tang, Wen Qin; Chng, Jake; Ler, Wei Xuan; Manan, Norhaizat Abdul; Sim, Lyn Chiin; Zheng, Zi Ying; Zhang, Wei; Walsh, Ian; Zijlstra, Gerben; Pennings, Maarten; Ng, Say Kong

Year: 2024

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202400092

Paper Comparison of mechanistic and hybrid modeling approaches for characterization of a CHO cultivation process: Requirements, pitfalls and solution paths

Bayer, Benjamin; Duerkop, Mark; Pörtner, Ralf et al. · 2022 · Biotechnology Journal · DOI

Full title: Comparison of mechanistic and hybrid modeling approaches for characterization of a CHO cultivation process: Requirements, pitfalls and solution paths

Authors: Bayer, Benjamin; Duerkop, Mark; Pörtner, Ralf; Möller, Johannes

Year: 2022

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202200381

Paper Novel Data‐Driven Mechanistic Modeling of Untargeted Metabolome Data Reveals Feed Component Effects in CHO Cell Bioprocess Using Column Generation‐Based EFMs

Mäkinen, Meeri; Zacharouli, Markella; Särnlund, Sigrid et al. · 2025 · Biotechnology Journal · DOI

Full title: Novel Data‐Driven Mechanistic Modeling of Untargeted Metabolome Data Reveals Feed Component Effects in CHO Cell Bioprocess Using Column Generation‐Based EFMs

Authors: Mäkinen, Meeri; Zacharouli, Markella; Särnlund, Sigrid; Jiang, Yun; Chotteau, Véronique

Year: 2025

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.70008

Paper Process‐induced cell cycle oscillations in CHO cultures: Online monitoring and model‐based investigation

Möller, Johannes; Bhat, Krathika; Riecken, Kristoffer et al. · 2019 · Biotechnology and Bioengineering · DOI

Full title: Process‐induced cell cycle oscillations in CHO cultures: Online monitoring and model‐based investigation

Authors: Möller, Johannes; Bhat, Krathika; Riecken, Kristoffer; Pörtner, Ralf; Zeng, An‐Ping; Jandt, Uwe

Year: 2019

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27124

Paper Media on‐demand: Continuous reconstitution of a chemically defined media directly from solids

Komuczki, Daniel; Dutra, Gregory; Gstöttner, Christoph et al. · 2021 · Biotechnology and Bioengineering · DOI

Full title: Media on‐demand: Continuous reconstitution of a chemically defined media directly from solids

Authors: Komuczki, Daniel; Dutra, Gregory; Gstöttner, Christoph; Domínguez‐Vega, Elena; Jungbauer, Alois; Satzer, Peter

Year: 2021

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27738

Paper Optimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided by design of experiments

Schwarz, Hubert; Lee, Kevin; Castan, Andreas et al. · 2023 · Biotechnology and Bioengineering · DOI

Full title: Optimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided by design of experiments

Authors: Schwarz, Hubert; Lee, Kevin; Castan, Andreas; Chotteau, Véronique

Year: 2023

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28397

Paper A compendium of stable hotspots in the CHO genome

Hilliard, William; Lee, Kelvin H. · 2023 · Biotechnology and Bioengineering · DOI

Full title: A compendium of stable hotspots in the CHO genome

Authors: Hilliard, William; Lee, Kelvin H.

Year: 2023

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28390

Paper Cell culture product quality attribute prediction using convolutional neural networks and Raman spectroscopy

Khodabandehlou, Hamid; Rashedi, Mohammad; Wang, Tony et al. · 2024 · Biotechnology and Bioengineering · DOI

Full title: Cell culture product quality attribute prediction using convolutional neural networks and Raman spectroscopy

Authors: Khodabandehlou, Hamid; Rashedi, Mohammad; Wang, Tony; Tulsyan, Aditya; Schorner, Gregg; Garvin, Christopher; Ündey, Cenk

Year: 2024

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28646

Paper Automated dynamic fed-batch process and media optimization for high productivity cell culture process development.

Lu, Franklin; Toh, Poh Choo; Burnett, Iain et al. · 2013 · Biotechnology and bioengineering · DOI

Full title: Automated dynamic fed-batch process and media optimization for high productivity cell culture process development.

Authors: Lu, Franklin; Toh, Poh Choo; Burnett, Iain; Li, Feng; Hudson, Terry; Amanullah, Ashraf; Li, Jincai

Year: 2013

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.24602

Paper Soft‐sensors application for automated feeding control in high‐throughput mammalian cell cultures

Martínez‐Monge, Iván; Martínez, Carlos A.; Decker, Marianne et al. · 2022 · Biotechnology and Bioengineering · DOI

Full title: Soft‐sensors application for automated feeding control in high‐throughput mammalian cell cultures

Authors: Martínez‐Monge, Iván; Martínez, Carlos A.; Decker, Marianne; Udugama, Isuru A.; Mas, Igor Marín de; Gernaey, Krist V.; Nielsen, Lars K.

Year: 2022

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28032

Paper Temporal Galactose‐Manganese Feeding in Fed‐Batch and Perfusion Bioreactors Modulates UDP‐Galactose Pools for Enhanced mAb Glycosylation Homogeneity

Gyorgypal, Aron; Fratz‐Berilla, Erica J.; Kohnhorst, Casey et al. · 2025 · Biotechnology and Bioengineering · DOI

Full title: Temporal Galactose‐Manganese Feeding in Fed‐Batch and Perfusion Bioreactors Modulates UDP‐Galactose Pools for Enhanced mAb Glycosylation Homogeneity

Authors: Gyorgypal, Aron; Fratz‐Berilla, Erica J.; Kohnhorst, Casey; Powers, David N.; Chundawat, Shishir P. S.

Year: 2025

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28999

Paper Machine learning‐based model predictive controller design for cell culture processes

Rashedi, Mohammad; Rafiei, Mina; Demers, Matthew et al. · 2023 · Biotechnology and Bioengineering · DOI

Full title: Machine learning‐based model predictive controller design for cell culture processes

Authors: Rashedi, Mohammad; Rafiei, Mina; Demers, Matthew; Khodabandehlou, Hamid; Wang, Tony; Tulsyan, Aditya; Ündey, Cenk; Garvin, Christopher

Year: 2023

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28486

Paper Mimicking CHO large‐scale effects in the single multicompartment bioreactor: A new approach to access scale‐up behavior

Gaugler, Lena; Hofmann, Sebastian; Schlüter, Michael et al. · 2024 · Biotechnology and Bioengineering · DOI

Full title: Mimicking CHO large‐scale effects in the single multicompartment bioreactor: A new approach to access scale‐up behavior

Authors: Gaugler, Lena; Hofmann, Sebastian; Schlüter, Michael; Takors, Ralf

Year: 2024

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28647

Paper A system identification approach for developing model predictive controllers of antibody quality attributes in cell culture processes

Downey, Brandon; Schmitt, John; Beller, Justin A. et al. · 2017 · Biotechnology Progress · DOI

Full title: A system identification approach for developing model predictive controllers of antibody quality attributes in cell culture processes

Authors: Downey, Brandon; Schmitt, John; Beller, Justin A.; Russell, Brian; Quach, Anthony; Hermann, Elizabeth; Lyon, David; Breit, Jeffrey F.

Year: 2017

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2537

Paper Developing an ultra‐intensified fed‐batch cell culture process with greatly improved performance and productivity

Shaoxun Xiang; Jinliang Zhang; Le Yu et al. · 2023 · Biotechnology and Bioengineering · DOI

Full title: Developing an ultra‐intensified fed‐batch cell culture process with greatly improved performance and productivity

Authors: Shaoxun Xiang; Jinliang Zhang; Le Yu; Jun Tian; Wenxiu Tang; Haozhong Tang; Kecui Xu; Xin Wang; Yanyan Cui; Kai Ren; Weijia Cao; Yuning Su; Weichang Zhou

Year: 2023

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28605

Paper Tuning monoclonal antibody galactosylation using Raman spectroscopy‐controlled lactic acid feeding

Eyster, Thomas W.; Talwar, Sameer; Fernandez, Janice et al. · 2020 · Biotechnology Progress · DOI

Full title: Tuning monoclonal antibody galactosylation using Raman spectroscopy‐controlled lactic acid feeding

Authors: Eyster, Thomas W.; Talwar, Sameer; Fernandez, Janice; Foster, Shelby; Hayes, James; Allen, Randal; Reidinger, Scot; Wan, Boyong; Ji, Xiao‐Dan; Aon, Juan C.; Patel, Pramthesh; Ritz, Diana

Year: 2020

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.3085

Paper Process model comparison and transferability across bioreactor scales and modes of operation for a mammalian cell bioprocess

Craven, Stephen; Shirsat, Nishikant; Whelan, Jessica et al. · 2012 · Biotechnology Progress · DOI

Full title: Process model comparison and transferability across bioreactor scales and modes of operation for a mammalian cell bioprocess

Authors: Craven, Stephen; Shirsat, Nishikant; Whelan, Jessica; Glennon, Brian

Year: 2012

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.1664

Paper Quick generation of Raman spectroscopy based in-process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture.

Berry, Brandon N; Dobrowsky, Terrence M; Timson, Rebecca C et al. · 2016 · Biotechnology progress · DOI

Full title: Quick generation of Raman spectroscopy based in-process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture.

Authors: Berry, Brandon N; Dobrowsky, Terrence M; Timson, Rebecca C; Kshirsagar, Rashmi; Ryll, Thomas; Wiltberger, Kelly

Year: 2016

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2205

Paper Physics‐informed neural networks for biopharmaceutical cultivation processes: Consideration of varying process parameter settings

Adebar, Niklas; Arnold, Sabine; Montano-Herrera, Liliana et al. · 2024 · Biotechnology and Bioengineering · DOI

Full title: Physics‐informed neural networks for biopharmaceutical cultivation processes: Consideration of varying process parameter settings

Authors: Adebar, Niklas; Arnold, Sabine; Montano-Herrera, Liliana; Emenike, Victor N.; Wucherpfennig, Thomas; Smiatek, Jens

Year: 2024

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28851

Paper CHO stable pool fed-batch process development of SARS-CoV-2 spike protein production: Impact of aeration conditions and feeding strategies.

Reyes, Sebastian-Juan; Pham, Phuong Lan; Durocher, Yves et al. · 2025 · Biotechnology progress · DOI

Full title: CHO stable pool fed-batch process development of SARS-CoV-2 spike protein production: Impact of aeration conditions and feeding strategies.

Authors: Reyes, Sebastian-Juan; Pham, Phuong Lan; Durocher, Yves; Henry, Olivier

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3507

Paper Neural ordinary differential equation‐based model predictive controller for regulating glucose concentration in a fed‐batch CHO cell bioreactor

Chiu, Kuo‐Chun; Du, Dongping · 2025 · The Canadian Journal of Chemical Engineering · DOI

Full title: Neural ordinary differential equation‐based model predictive controller for regulating glucose concentration in a fed‐batch CHO cell bioreactor

Authors: Chiu, Kuo‐Chun; Du, Dongping

Year: 2025

Venue: The Canadian Journal of Chemical Engineering

DOI: https://doi.org/10.1002/cjce.25623

Paper Process development for an inducible rituximab‐expressing Chinese hamster ovary cell line

Mellahi, Kahina; Cambay, Florian; Brochu, Denis et al. · 2018 · Biotechnology Progress · DOI

Full title: Process development for an inducible rituximab‐expressing Chinese hamster ovary cell line

Authors: Mellahi, Kahina; Cambay, Florian; Brochu, Denis; Gilbert, Michel; Perrier, Pascal; Ansorge, Sven; Durocher, Yves; Henry, Olivier

Year: 2018

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2742

Paper Real‐time quantification and supplementation of bioreactor amino acids to prolong culture time and maintain antibody product quality

Powers, David N.; Wang, Yifan; Fratz‐Berilla, Erica J. et al. · 2019 · Biotechnology Progress · DOI

Full title: Real‐time quantification and supplementation of bioreactor amino acids to prolong culture time and maintain antibody product quality

Authors: Powers, David N.; Wang, Yifan; Fratz‐Berilla, Erica J.; Velugula‐Yellela, Sai Rashmika; Chavez, Brittany; Angart, Phillip; Trunfio, Nicholas; Yoon, Seongkyu; Agarabi, Cyrus

Year: 2019

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2894

Paper A recurrent neural network for soft sensor development using CHO stable pools in fed‐batch process for SARS ‐ CoV ‐2 spike protein production as a vaccine antigen

Reyes, Sebastian‐Juan; Voyer, Robert; Durocher, Yves et al. · 2025 · Biotechnology Progress · DOI

Full title: A recurrent neural network for soft sensor development using CHO stable pools in fed‐batch process for SARS ‐ CoV ‐2 spike protein production as a vaccine antigen

Authors: Reyes, Sebastian‐Juan; Voyer, Robert; Durocher, Yves; Henry, Olivier; Pham, Phuong Lan

Year: 2025

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.70046

Paper Raman-based dynamic feeding strategies using real-time glucose concentration monitoring system during adalimumab producing CHO cell cultivation.

Domján, Júlia; Fricska, Annamária; Madarász, Lajos et al. · 2020 · Biotechnology progress · DOI

Full title: Raman-based dynamic feeding strategies using real-time glucose concentration monitoring system during adalimumab producing CHO cell cultivation.

Authors: Domján, Júlia; Fricska, Annamária; Madarász, Lajos; Gyürkés, Martin; Köte, Ákos; Farkas, Attila; Vass, Panna; Fehér, Csaba; Horváth, Balázs; Könczöl, Kálmán; Pataki, Hajnalka; Nagy, Zsombor Kristóf; Marosi, György János; Hirsch, Edit

Year: 2020

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3052

Paper Controlled release of nutrients to mammalian cells cultured in shake flasks

Swati Hegde; T. Pant; Ketaki Pradhan et al. · 2012 · Biotechnology progress (Print) · DOI

Full title: Controlled release of nutrients to mammalian cells cultured in shake flasks

Authors: Swati Hegde; T. Pant; Ketaki Pradhan; M. Badiger; M. Gadgil

Year: 2012

Venue: Biotechnology progress (Print)

DOI: https://doi.org/10.1002/btpr.729

Paper A protocol to transfer a fed‐batch platform process into semi‐perfusion mode: The benefit of automated small‐scale bioreactors compared to shake flasks as scale‐down model

Janoschek, Sabrina; Schulze, Markus; Zijlstra, Gerben et al. · 2018 · Biotechnology Progress · DOI

Full title: A protocol to transfer a fed‐batch platform process into semi‐perfusion mode: The benefit of automated small‐scale bioreactors compared to shake flasks as scale‐down model

Authors: Janoschek, Sabrina; Schulze, Markus; Zijlstra, Gerben; Greller, Gerhard; Matuszczyk, Jens

Year: 2018

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2757

Paper An assessment of the impact of Raman based glucose feedback control on CHO cell bioreactor process development

Gibbons, Luke; Maslanka, Francis; Le, Nikky et al. · 2023 · Biotechnology Progress · DOI

Full title: An assessment of the impact of Raman based glucose feedback control on CHO cell bioreactor process development

Authors: Gibbons, Luke; Maslanka, Francis; Le, Nikky; Magill, Al; Singh, Pankaj Kumar; McLaughlin, Joseph K.; Madden, Fiona; Hayes, Ronan; McCarthy, Barry; Rode, Christopher K.; O’Mahony, Jim; Rea, Rosemary; O'Mahony‐Hartnett, Caitlin

Year: 2023

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.3371

Paper A statistical approach to improve compound screening in cell culture media

Puente‐Massaguer, Eduard; Badiella, Llorenç; Gutiérrez-Granados, Sònia et al. · 2019 · Engineering in Life Sciences · DOI

Full title: A statistical approach to improve compound screening in cell culture media

Authors: Puente‐Massaguer, Eduard; Badiella, Llorenç; Gutiérrez-Granados, Sònia; Cervera, Laura; Gòdia, Francesc

Year: 2019

Venue: Engineering in Life Sciences

DOI: https://doi.org/10.1002/elsc.201800168

Paper Elevated pCO 2 affects the lactate metabolic shift in CHO cell culture processes

Brunner, Matthias; Doppler, Philipp; Klein, Tobias et al. · 2017 · Engineering in Life Sciences · DOI

Full title: Elevated pCO 2 affects the lactate metabolic shift in CHO cell culture processes

Authors: Brunner, Matthias; Doppler, Philipp; Klein, Tobias; Herwig, Christoph; Fricke, Jens

Year: 2017

Venue: Engineering in Life Sciences

DOI: https://doi.org/10.1002/elsc.201700131

Paper N‐1 semi‐continuous transient perfusion in shake flask for ultra‐high density seeding of CHO cell cultures in benchtop bioreactors

Lemire, Lucas; Reyes, Sebastian‐Juan; Durocher, Yves et al. · 2025 · Biotechnology Progress · DOI

Full title: N‐1 semi‐continuous transient perfusion in shake flask for ultra‐high density seeding of CHO cell cultures in benchtop bioreactors

Authors: Lemire, Lucas; Reyes, Sebastian‐Juan; Durocher, Yves; Voyer, Robert; Henry, Olivier; Pham, Phuong Lan

Year: 2025

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.70029

Paper Rapid total sialic acid monitoring during cell culture process using a machine learning model based soft sensor

Behdani, Amir M.; Zhao, Yuxiang; Yao, Grace et al. · 2024 · Biotechnology Progress · DOI

Full title: Rapid total sialic acid monitoring during cell culture process using a machine learning model based soft sensor

Authors: Behdani, Amir M.; Zhao, Yuxiang; Yao, Grace; Wasalathanthri, Dhanuka P.; Hodgman, Eric; Borys, Michael; Li, Gloria; Khetan, Anurag; Wijesinghe, Dayanjan S.; Leone, Anthony

Year: 2024

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.3493

Paper Automized inline monitoring in perfused mammalian cell culture by MIR spectroscopy without calibration model building

Marienberg, Hannah; Desch, Nicole; Mozin, Vitalii et al. · 2023 · Engineering in Life Sciences · DOI

Full title: Automized inline monitoring in perfused mammalian cell culture by MIR spectroscopy without calibration model building

Authors: Marienberg, Hannah; Desch, Nicole; Mozin, Vitalii; Sykora‐Mirle, Lorenz; Müller, Anja; Roth, Andreas; Käfer, Mathias; Neef, Rüdiger

Year: 2023

Venue: Engineering in Life Sciences

DOI: https://doi.org/10.1002/elsc.202300237

Paper Dynamic pH profiles drive higher cell‐specific and volumetric productivity

Klaubert, Stephanie R.; Chitwood, Dylan G.; Peng, Danqia et al. · 2025 · Biotechnology Progress · DOI

Full title: Dynamic pH profiles drive higher cell‐specific and volumetric productivity

Authors: Klaubert, Stephanie R.; Chitwood, Dylan G.; Peng, Danqia; Redman, Erin; Anderson, Ji Young L.; Sandoval, Nicholas R.; Harcum, Sarah W.

Year: 2025

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.70080

Paper Stress‐induced increase of monoclonal antibody production in CHO cells

Schellenberg, Jana; Nagraik, Tamanna; Wohlenberg, Ole Jacob et al. · 2022 · Engineering in Life Sciences · DOI

Full title: Stress‐induced increase of monoclonal antibody production in CHO cells

Authors: Schellenberg, Jana; Nagraik, Tamanna; Wohlenberg, Ole Jacob; Rühl, Sebastian; Bahnemann, Janina; Scheper, Thomas; Solle, Dörte

Year: 2022

Venue: Engineering in Life Sciences

DOI: https://doi.org/10.1002/elsc.202100062

Paper Revisiting Verhulst and Monod models: analysis of batch and fed-batch cultures

Shirsat, Nishikant; Avesh, Mohd; Whelan, Jessica et al. · 2014 · Cytotechnology · DOI

Full title: Revisiting Verhulst and Monod models: analysis of batch and fed-batch cultures

Authors: Shirsat, Nishikant; Avesh, Mohd; Whelan, Jessica; English, Niall J.; Glennon, Brian; Al‐Rubeai, Mohamed

Year: 2014

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-014-9712-5

Paper Performance benchmark of different cell clones in discontinuous and continuous bioprocesses reveals critical impact of cellular diameter

Reger, Lucas Nik; Wijffels, René H.; Martens, Dirk E. et al. · 2024 · Biochemical Engineering Journal · DOI

Full title: Performance benchmark of different cell clones in discontinuous and continuous bioprocesses reveals critical impact of cellular diameter

Authors: Reger, Lucas Nik; Wijffels, René H.; Martens, Dirk E.; Niemann, Julia

Year: 2024

Venue: Biochemical Engineering Journal

DOI: https://doi.org/10.1016/j.bej.2024.109359

Paper Maduramycin, a novel glycosylation modulator for mammalian fed-batch and steady-state perfusion processes

Romann, Patrick; Vuillemin, Thomas; Pavone, Silvia et al. · 2024 · Journal of Biotechnology · DOI

Full title: Maduramycin, a novel glycosylation modulator for mammalian fed-batch and steady-state perfusion processes

Authors: Romann, Patrick; Vuillemin, Thomas; Pavone, Silvia; Jordan, Martin; Périlleux, Arnaud; Souquet, Jonathan; Bielser, Jean‐Marc; Herwig, Christoph; Villiger, Thomas K.

Year: 2024

Venue: Journal of Biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2024.02.003

Paper Towards the Development of Automated Fed-Batch Cell Culture Processes at Microscale

Wiegmann, Vincent; Γιάκα, Μαρία; Martinez, Cristina Bernal et al. · 2019 · BioTechniques · DOI

Full title: Towards the Development of Automated Fed-Batch Cell Culture Processes at Microscale

Authors: Wiegmann, Vincent; Γιάκα, Μαρία; Martinez, Cristina Bernal; Baganz, Frank

Year: 2019

Venue: BioTechniques

DOI: https://doi.org/10.2144/btn-2019-0063

Thesis Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Martínez-Monge, I.; Martínez, C.; Decker, M. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Authors: Martínez-Monge, I.; Martínez, C.; Decker, M.; Udugama, I. A.; Marín de Mas, I.; Gernaey, K. V.; id_orcid 0000-0002-0364-1773; Nielsen, L. K.

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3b1685d4-5ab9-4737-b414-d28fecf9b9eb

Thesis N-Glycosylation optimization of recombinant antibodies in CHO cell through process and metabolic engineering

Fan, Yuzhou · 2015 · Technical University of Denmark (DTU) · DOI

Full title: N-Glycosylation optimization of recombinant antibodies in CHO cell through process and metabolic engineering

Authors: Fan, Yuzhou

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0d46b1c0-0617-4c4e-8295-079e1eddaf3e

Thesis Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process

Calmels, Cyrielle; McCann, Andréa; Malphettes, Laetitia et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process

Authors: Calmels, Cyrielle; McCann, Andréa; Malphettes, Laetitia; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/59c3f8ac-571d-4312-969f-4d6d5689e961

Thesis Dynamic Optimization for Monoclonal Antibody Production

Kaysfeld, Morten Wahlgreen; Kumar, Deepak; Nielsen, Marcus Krogh et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Dynamic Optimization for Monoclonal Antibody Production

Authors: Kaysfeld, Morten Wahlgreen; Kumar, Deepak; Nielsen, Marcus Krogh; Jørgensen, John Bagterp; id_orcid 0000-0001-9799-2808

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9ff2d615-438b-414d-a0e2-29da79c7a72c

Thesis Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity

Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity

Authors: Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Kildegaard, Helene Faustrup; Min Lee, Gyun

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b93398cc-7060-452d-87ce-fc9c3bf95dd0

Thesis Engineering death resistance in CHO cells for improved perfusion culture

MacDonald, Michael A.; Nöbel, Matthias; Martínez, Verónica S. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Engineering death resistance in CHO cells for improved perfusion culture

Authors: MacDonald, Michael A.; Nöbel, Matthias; Martínez, Verónica S.; Baker, Kym; Shave, Evan; Gray, Peter P.; Mahler, Stephen; Munro, Trent; Nielsen, Lars K.; Marcellin, Esteban

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ce202b32-0a67-4570-a87a-ab0849f12696

Thesis Applying an MPC algorithm to the dissolved oxygen level of an intermittent fed-batch process

Pably, P.; Huusom, J. K.; id_orcid 0000-0002-1367-7235 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Applying an MPC algorithm to the dissolved oxygen level of an intermittent fed-batch process

Authors: Pably, P.; Huusom, J. K.; id_orcid 0000-0002-1367-7235; Kager, J.; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e5bf89bb-2803-4e21-a9e6-46f1fe8b45c3

Thesis Network Reconstruction and In Silico Metabolic Model of Chinese Hamster Ovary cells

Calmels, Cyrielle · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Network Reconstruction and In Silico Metabolic Model of Chinese Hamster Ovary cells

Authors: Calmels, Cyrielle

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e8e79519-7089-44aa-9964-6700b9af9251

Thesis Model Predictive Control of dissolved oxygen level in an intermittent fed-batch process – Simulation & Application

Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Model Predictive Control of dissolved oxygen level in an intermittent fed-batch process – Simulation & Application

Authors: Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235; Kager, Julian; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/fe55fd04-e378-4860-b304-b314688d1774

Thesis Glycoprofiling effects of media additives on IgG produced by CHO cells in fed-batch bioreactors

Kildegaard, Helene Faustrup; Fan, Yuzhou; Wagtberg Sen, Jette et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Glycoprofiling effects of media additives on IgG produced by CHO cells in fed-batch bioreactors

Authors: Kildegaard, Helene Faustrup; Fan, Yuzhou; Wagtberg Sen, Jette; Larsen, Bo; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/06580715-5855-4a31-b7d8-a2a4f0dff2c4

Thesis N-Glycosylation optimization of recombinant antibodies in CHO cell through process and metabolic engineering

Fan, Yuzhou · 2015 · Technical University of Denmark (DTU) · DOI

Full title: N-Glycosylation optimization of recombinant antibodies in CHO cell through process and metabolic engineering

Authors: Fan, Yuzhou

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0d46b1c0-0617-4c4e-8295-079e1eddaf3e

Thesis Model Predictive Control of dissolved oxygen level in an intermittent fed-batch process – Simulation & Application

Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Model Predictive Control of dissolved oxygen level in an intermittent fed-batch process – Simulation & Application

Authors: Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235; Kager, Julian; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/fe55fd04-e378-4860-b304-b314688d1774

Thesis Artificial neural network associated to UV/Vis spectroscopy for monitoring bioreactions in biopharmaceutical processes

Takahashi, Maria Beatriz [UNESP]; Leme, Jaci; Caricati, Celso Pereira et al. · 2015 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Artificial neural network associated to UV/Vis spectroscopy for monitoring bioreactions in biopharmaceutical processes

Authors: Takahashi, Maria Beatriz [UNESP]; Leme, Jaci; Caricati, Celso Pereira; Tonso, Aldo; Nuñez, Eutimio Gustavo Fernández [UNESP]; Rocha, José Celso [UNESP]

Year: 2015

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://hdl.handle.net/11449/126758

Thesis A Streamlined Multivariate Analysis Platform for Optimizing Mammalian Cell Culture and Biologics Production

Mingee, Andrew Nicholas · 2021 · Georgia Institute of Technology · DOI

Full title: A Streamlined Multivariate Analysis Platform for Optimizing Mammalian Cell Culture and Biologics Production

Authors: Mingee, Andrew Nicholas

Year: 2021

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/65145

Thesis Effect of Feed Rate on Growth Rate and Antibody Production in the Fed-batch Culture of Murine Hybridoma Cells

Jang, JD; Barford, JP · 2000 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Effect of Feed Rate on Growth Rate and Antibody Production in the Fed-batch Culture of Murine Hybridoma Cells

Authors: Jang, JD; Barford, JP

Year: 2000

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-24332

Thesis Simulation and dynamic optimisation of animal cell culture

Barford, John Patrick; Sanderson, Charles S.; Barton, Geoffrey W. · 1997 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Simulation and dynamic optimisation of animal cell culture

Authors: Barford, John Patrick; Sanderson, Charles S.; Barton, Geoffrey W.

Year: 1997

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68866

Thesis The use of biosensors in control of fed-batch processes - Opportunities and limitations

Renneberg, R.; Barford, JP; Tse, SMA · 1998 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: The use of biosensors in control of fed-batch processes - Opportunities and limitations

Authors: Renneberg, R.; Barford, JP; Tse, SMA

Year: 1998

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-44080

Thesis A comparison of different culture methods for hybridoma propagation and monoclonal antibody production

Barford, John Patrick; Marquis, Christopher Peter; Harbour, Colin et al. · 1990 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: A comparison of different culture methods for hybridoma propagation and monoclonal antibody production

Authors: Barford, John Patrick; Marquis, Christopher Peter; Harbour, Colin; Löw, K.S.

Year: 1990

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68971

Thesis Utilising a genome scale metabolic model to design high-producing CHO cell lines through bi-level optimisation

Antonakoudis, Athanasios · 2024 · Imperial College London · DOI

Full title: Utilising a genome scale metabolic model to design high-producing CHO cell lines through bi-level optimisation

Authors: Antonakoudis, Athanasios

Year: 2024

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/110783

Thesis Towards advanced bioprocess optimization: a multiscale modelling approach

Monteiro, Mariana; Fadda, Sarah; Kontoravdi, Kleio · 2023 · Imperial College London · DOI

Full title: Towards advanced bioprocess optimization: a multiscale modelling approach

Authors: Monteiro, Mariana; Fadda, Sarah; Kontoravdi, Kleio

Year: 2023

Venue: Imperial College London

DOI: https://www.sciencedirect.com/science/article/pii/S2001037023002362

Thesis Amino acid metabolism in Chinese hamster ovary cell culture

Kyriakopoulos, Sarantos · 2015 · Imperial College London · DOI

Full title: Amino acid metabolism in Chinese hamster ovary cell culture

Authors: Kyriakopoulos, Sarantos

Year: 2015

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/25143

Thesis From titer to quality: exploring reinforcement learning for bioprocess control in silico

Monteiro, Mariana; Flevaris, Konstantinos; Kontoravdi, Cleo · 2025 · Imperial College London · DOI

Full title: From titer to quality: exploring reinforcement learning for bioprocess control in silico

Authors: Monteiro, Mariana; Flevaris, Konstantinos; Kontoravdi, Cleo

Year: 2025

Venue: Imperial College London

DOI: https://hdl.handle.net/10044/1/124760

Thesis Assessment of the interactions between bioprocess conditions and protein glycosylation in antibody- producing mammalian cell cultures

Jimenez Del Val, Ioscani · 2014 · Imperial College London · DOI

Full title: Assessment of the interactions between bioprocess conditions and protein glycosylation in antibody- producing mammalian cell cultures

Authors: Jimenez Del Val, Ioscani

Year: 2014

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/15160

Thesis Genome-Based Metabolic Modelling of CHO Cells

Chen, Ning · 2013 · Imperial College London · DOI

Full title: Genome-Based Metabolic Modelling of CHO Cells

Authors: Chen, Ning

Year: 2013

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/11054

Thesis A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation

Jimenez del Val, I; Polizzi, K; Kontoravdi, C · 2016 · Imperial College London · DOI

Full title: A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation

Authors: Jimenez del Val, I; Polizzi, K; Kontoravdi, C

Year: 2016

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/33608

Thesis Cascading effect in bioprocessing – the impact of mild hypothermia on CHO cell behavior and host cell protein composition

Goey, CH; Tsang, J; Bell, D et al. · 2017 · Imperial College London · DOI

Full title: Cascading effect in bioprocessing – the impact of mild hypothermia on CHO cell behavior and host cell protein composition

Authors: Goey, CH; Tsang, J; Bell, D; Kontoravdi, C

Year: 2017

Venue: Imperial College London

DOI: https://onlinelibrary.wiley.com/doi/epdf/10.1002/bit.26437

Thesis Systematic development of predictive mathematical models for animal cell cultures

Kontoravdi, Cleo; Pistikopoulos, Efstratios N; Mantalaris, Athanasios · 2014 · Imperial College London · DOI

Full title: Systematic development of predictive mathematical models for animal cell cultures

Authors: Kontoravdi, Cleo; Pistikopoulos, Efstratios N; Mantalaris, Athanasios

Year: 2014

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000279658700003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Novel in vivo biosensors for monitoring of mammalian cell cultures

Goers, Lisa · 2017 · Imperial College London · DOI

Full title: Novel in vivo biosensors for monitoring of mammalian cell cultures

Authors: Goers, Lisa

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/44463

Thesis A platform for the optimisation of metabolic pathways for glycosylation to achieve a narrow and targeted glycoform distribution

Jedrzejewski, Philip · 2017 · Imperial College London · DOI

Full title: A platform for the optimisation of metabolic pathways for glycosylation to achieve a narrow and targeted glycoform distribution

Authors: Jedrzejewski, Philip

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/53386

Thesis Constrained global sensitivity analysis for bioprocess design space identification

Kotidis, Pavlos; Demis, Panagiotis; Goey, Cher et al. · 2019 · Imperial College London · DOI

Full title: Constrained global sensitivity analysis for bioprocess design space identification

Authors: Kotidis, Pavlos; Demis, Panagiotis; Goey, Cher; Correa, Elisa; McIntosh, calum; Trepekli, Stefania; Shah, Nilay; Klymenko, Oleksiy; Kontoravdi, Kleio

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/66121

Thesis Towards controlling the glycoform: a model framework linking extracellular metabolites to antibody glycosylation

Jedrzejewski, PM; Jimenez del Val, I; Constantinou, A et al. · 2018 · Imperial College London · DOI

Full title: Towards controlling the glycoform: a model framework linking extracellular metabolites to antibody glycosylation

Authors: Jedrzejewski, PM; Jimenez del Val, I; Constantinou, A; Dell, A; Haslam, SM; Polizzi, KM; Kontoravdi, C

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/63403

Thesis In silico dynamic optimisation studies for batch/fed-batch mammalian cell suspension cultures producing biopharmaceuticals

Lam, Ming-Chi · 2017 · Imperial College London · DOI

Full title: In silico dynamic optimisation studies for batch/fed-batch mammalian cell suspension cultures producing biopharmaceuticals

Authors: Lam, Ming-Chi

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/45465

Thesis Mathematical modelling for bioprocess understanding and optimisation

Alhuthali, Sakhr · 2020 · Imperial College London · DOI

Full title: Mathematical modelling for bioprocess understanding and optimisation

Authors: Alhuthali, Sakhr

Year: 2020

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/84849

Thesis Mathematical modelling and experimental validation for optimisation and control of mammalian cell culture systems

Quiroga Campano, Ana · 2019 · Imperial College London · DOI

Full title: Mathematical modelling and experimental validation for optimisation and control of mammalian cell culture systems

Authors: Quiroga Campano, Ana

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/68071

Thesis Population balance modelling captures host cell protein dynamics in CHO cell cultures

Alhuthali, Sakhr; Kontoravdi, Cleo · 2022 · Imperial College London · DOI

Full title: Population balance modelling captures host cell protein dynamics in CHO cell cultures

Authors: Alhuthali, Sakhr; Kontoravdi, Cleo

Year: 2022

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/96277

Thesis Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra

Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn et al. · 2021 · Utrecht University · DOI

Full title: Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra

Authors: Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn; Mastrobattista, Enrico; Yamabhai, Montarop

Year: 2021

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/419433

Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn et al. · 2021 · Utrecht University · DOI

Authors: Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn; Mastrobattista, Enrico; Yamabhai, Montarop

Year: 2021

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/418108

Thesis Industry 4.0 in Biomanufacturing: Predictive Real-Time Models Using Process Analytical Technology

Murr, Michaela · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Industry 4.0 in Biomanufacturing: Predictive Real-Time Models Using Process Analytical Technology

Authors: Murr, Michaela

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/151710

Thesis Metabolomics-driven investigation of novel growth inhibitors in CHO cell bioprocessing

Johnston, Luke · 2025 · The University of Edinburgh · DOI

Full title: Metabolomics-driven investigation of novel growth inhibitors in CHO cell bioprocessing

Authors: Johnston, Luke

Year: 2025

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/44239

Thesis Actionable Modeling: Elucidate Enzyme Interactions in Complex Biosynthesis Systems by Interpretable Models from Omics Data

Liang, Chenguang · 2024 · University of California, San Diego (UCSD) · DOI

Full title: Actionable Modeling: Elucidate Enzyme Interactions in Complex Biosynthesis Systems by Interpretable Models from Omics Data

Authors: Liang, Chenguang

Year: 2024

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/5d80m694

Thesis Effect of Cell Culture Environment on the Stability of IgG1

Anderson, Kimberley · 2018 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Effect of Cell Culture Environment on the Stability of IgG1

Authors: Anderson, Kimberley

Year: 2018

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/25641/1/Thesis_Kimberley_Anderson%20v5.0.docx

Thesis Characterization of Fibra-Cel® packed-bed bioreactors for the culture of CHO cells

Meuwly, Frédéric · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Characterization of Fibra-Cel® packed-bed bioreactors for the culture of CHO cells

Authors: Meuwly, Frédéric

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/218454

Thesis Process development for the production of monoclonal IgA antibodies that protect mucosal surfaces

Stoll, T. S.; Perregaux, C.; Stockar, U. von et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Process development for the production of monoclonal IgA antibodies that protect mucosal surfaces

Authors: Stoll, T. S.; Perregaux, C.; Stockar, U. von; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/225978

Thesis Production of immunoglobulin A in different reactor configurations

Stoll, T.; Perregaux, C.; Von Stockar, U. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Production of immunoglobulin A in different reactor configurations

Authors: Stoll, T.; Perregaux, C.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/225985

Thesis Development of an online control system for the cultivation of animal cells in a hollow-fiber reactor using flow injection analysis and a visual programming language

Stoll, T. S.; Ruffieux, P. A.; von Stockar, U. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Development of an online control system for the cultivation of animal cells in a hollow-fiber reactor using flow injection analysis and a visual programming language

Authors: Stoll, T. S.; Ruffieux, P. A.; von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226005

Thesis Effects of culture conditions on the production and quality of monoclonal IgA

Stoll, T. S.; Chappaz, A.; von Stockar, U. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Effects of culture conditions on the production and quality of monoclonal IgA

Authors: Stoll, T. S.; Chappaz, A.; von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226015

Thesis Real-time in situ monitoring of freely suspended and immobilized cell cultures based on mid-infrared spectroscopic measurements

Rhiel, Martin; Ducommun, Paul; Bolzonella, Ivan et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Real-time in situ monitoring of freely suspended and immobilized cell cultures based on mid-infrared spectroscopic measurements

Authors: Rhiel, Martin; Ducommun, Paul; Bolzonella, Ivan; Marison, Ian; Von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226062

Thesis Mid-infrared spectroscopic monitoring of animal cell culture bioreactor processes

Rhiel, M.; Ziegler, T.; Ducommun, P. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Mid-infrared spectroscopic monitoring of animal cell culture bioreactor processes

Authors: Rhiel, M.; Ziegler, T.; Ducommun, P.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226036

Thesis On-line biomass monitoring with scanning dielectric spectroscopy

Cannizzaro, Christopher M.; Valentinotti, Sergio; Marison, Ian W. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-line biomass monitoring with scanning dielectric spectroscopy

Authors: Cannizzaro, Christopher M.; Valentinotti, Sergio; Marison, Ian W.; von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226087

Thesis On-line determination of animal cell concentration in two industrial high-density culture processes by dielectric spectroscopy

Ducommun, P.; Kadouri, A.; Von Stockar, U. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-line determination of animal cell concentration in two industrial high-density culture processes by dielectric spectroscopy

Authors: Ducommun, P.; Kadouri, A.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226068

Thesis On-line determination of animal cell concentration

Ducommun, P.; Bolzonella, I.; Rhiel, M. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-line determination of animal cell concentration

Authors: Ducommun, P.; Bolzonella, I.; Rhiel, M.; Pugeaud, P.; von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226053

Thesis ENGINEERING BIOSENSOR CELL LINES TO INVESTIGATE INTRACELLULAR IMPACTS OF MAMMALIAN BIOPROCESSES

McFarland, Kevin Stephen · 2023 · Johns Hopkins University · DOI

Full title: ENGINEERING BIOSENSOR CELL LINES TO INVESTIGATE INTRACELLULAR IMPACTS OF MAMMALIAN BIOPROCESSES

Authors: McFarland, Kevin Stephen

Year: 2023

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/68933

Thesis BRIDGING EXPERIMENTAL AND IN-SILICO METHODS FOR ADVANCED MAMMALIAN BIOMANUFACTURING OPTIMIZATION

Ndahiro, Nelson · 2025 · Johns Hopkins University · DOI

Full title: BRIDGING EXPERIMENTAL AND IN-SILICO METHODS FOR ADVANCED MAMMALIAN BIOMANUFACTURING OPTIMIZATION

Authors: Ndahiro, Nelson

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70287

Thesis STRUCTURAL IMPLICATIONS OF GLUCOSE AND COPPER AVAILABILITY ON GLYCATION PROCESSES IN CHINESE HAMSTER OVARIAN (CHO) CELL-DERIVED PROTEINS

Vasamsetti, Sree Lakshmi Harita · 2025 · Johns Hopkins University · DOI

Full title: STRUCTURAL IMPLICATIONS OF GLUCOSE AND COPPER AVAILABILITY ON GLYCATION PROCESSES IN CHINESE HAMSTER OVARIAN (CHO) CELL-DERIVED PROTEINS

Authors: Vasamsetti, Sree Lakshmi Harita

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70784

Thesis Development and validation of a hybrid model for prediction of viable cell density, titer and cumulative glucose consumption in a mammalian cell culture system

Yatipanthalawa, BS; Wallace Fitzsimons, SE; Horning, T et al. · 2024 · University of Melbourne · DOI

Full title: Development and validation of a hybrid model for prediction of viable cell density, titer and cumulative glucose consumption in a mammalian cell culture system

Authors: Yatipanthalawa, BS; Wallace Fitzsimons, SE; Horning, T; Lee, YY; Gras, SL

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/345116

Thesis Software sensors as a tool for optimization of animal-cell cultures

Dorresteijn, R.C. · 1997 · Wageningen University & Research · DOI

Full title: Software sensors as a tool for optimization of animal-cell cultures

Authors: Dorresteijn, R.C.

Year: 1997

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/software-sensors-as-a-tool-for-optimization-of-animal-cell-cultur

Thesis On-line monitoring and control of animal-cell cultures

van der Pol, J.J. · 1996 · Wageningen University & Research · DOI

Full title: On-line monitoring and control of animal-cell cultures

Authors: van der Pol, J.J.

Year: 1996

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/on-line-monitoring-and-control-of-animal-cell-cultures

Thesis Transcriptomic profiling as a tool to characterize CHO cell processes

Al Sayyari, Abdulaziz Abdullah · 2018 · Wageningen University & Research · DOI

Full title: Transcriptomic profiling as a tool to characterize CHO cell processes

Authors: Al Sayyari, Abdulaziz Abdullah

Year: 2018

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/transcriptomic-profiling-as-a-tool-to-characterize-cho-cell-proce

Thesis Acoustic perfusion processes for hybridoma cultures: viability, cell cycle and metabolic analysis

Dalm, M.C.F. · 2007 · Wageningen University & Research · DOI

Full title: Acoustic perfusion processes for hybridoma cultures: viability, cell cycle and metabolic analysis

Authors: Dalm, M.C.F.

Year: 2007

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/acoustic-perfusion-processes-for-hybridoma-cultures-viability-cel

Thesis Characterization and optimization of a CHO antibody manufacturing process

Reger, Lucas Nik · 2025 · Wageningen University & Research · DOI

Full title: Characterization and optimization of a CHO antibody manufacturing process

Authors: Reger, Lucas Nik

Year: 2025

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/characterization-and-optimization-of-a-cho-antibody-manufacturing

Thesis Targeting miRNAs with CRISPR/Cas9 to Improve Recombinant Protein Production of CHO Cells

Kellner, Kevin; Solanki, Ankur; Amann, Thomas et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Targeting miRNAs with CRISPR/Cas9 to Improve Recombinant Protein Production of CHO Cells

Authors: Kellner, Kevin; Solanki, Ankur; Amann, Thomas; Lao, Nga; Barron, Niall

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/437280a5-1393-422a-9a9d-00f68443909f

Thesis Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Martínez-Monge, I.; Martínez, C.; Decker, M. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Authors: Martínez-Monge, I.; Martínez, C.; Decker, M.; Udugama, I. A.; Marín de Mas, I.; Gernaey, K. V.; id_orcid 0000-0002-0364-1773; Nielsen, L. K.

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3b1685d4-5ab9-4737-b414-d28fecf9b9eb

Thesis Systematic Methodology for Reproducible Optimizing Batch Operation

Bonné, Dennis; Jørgensen, Sten Bay; id_orcid 0000-0002-3179-972X · 2006 · Technical University of Denmark (DTU) · DOI

Full title: Systematic Methodology for Reproducible Optimizing Batch Operation

Authors: Bonné, Dennis; Jørgensen, Sten Bay; id_orcid 0000-0002-3179-972X

Year: 2006

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4b220b1c-6bd2-4eb7-ac7f-0f5353ddfeb6

Thesis A Method for Systematic Improvement of Stochastic Grey-Box Models

Kristensen, Niels Rode; Madsen, Henrik; id_orcid 0000-0003-0690-3713 et al. · 2004 · Technical University of Denmark (DTU) · DOI

Full title: A Method for Systematic Improvement of Stochastic Grey-Box Models

Authors: Kristensen, Niels Rode; Madsen, Henrik; id_orcid 0000-0003-0690-3713; Jørgensen, Sten Bay; id_orcid 0000-0002-3179-972X

Year: 2004

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/55695fc1-7d99-4173-8d94-51f9e06b3ec1

Thesis Concomitant consumption of glucose and lactate: A novel batch production process for CHO cells

Martínez-Monge, I.; Comas, P.; Triquell, J. et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Concomitant consumption of glucose and lactate: A novel batch production process for CHO cells

Authors: Martínez-Monge, I.; Comas, P.; Triquell, J.; Casablancas, A.; Lecina, M.; Paredes, C.J.; Cairó, J.J.

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5dbc1c02-f271-4f18-8ccd-422ca2b145c2

Thesis Potential of predictive model-based dissolved oxygen control for intermittent fed-batch processes

Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Potential of predictive model-based dissolved oxygen control for intermittent fed-batch processes

Authors: Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235; Kager, Julian; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/672b1410-685c-430d-9a82-cd4a33c61d66

Thesis Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process

Calmels, Cyrielle; McCann, Andréa; Malphettes, Laetitia et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process

Authors: Calmels, Cyrielle; McCann, Andréa; Malphettes, Laetitia; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/59c3f8ac-571d-4312-969f-4d6d5689e961

Thesis Development and Application of a Novel Free-floating Sensor Device for Bioprocess Optimization

Bisgaard, Jonas · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Development and Application of a Novel Free-floating Sensor Device for Bioprocess Optimization

Authors: Bisgaard, Jonas

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a5765731-0e3a-4e97-942e-0b93dbe22c31

Thesis Dynamic Optimization for Monoclonal Antibody Production

Kaysfeld, Morten Wahlgreen; Kumar, Deepak; Nielsen, Marcus Krogh et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Dynamic Optimization for Monoclonal Antibody Production

Authors: Kaysfeld, Morten Wahlgreen; Kumar, Deepak; Nielsen, Marcus Krogh; Jørgensen, John Bagterp; id_orcid 0000-0001-9799-2808

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9ff2d615-438b-414d-a0e2-29da79c7a72c

Thesis Comparison of spectroscopy technologies for improved monitoring of cell culture processes in miniature bioreactors

Rowland-Jones, Ruth C.; van der Berg, Franciscus Winfried J; Racher, Andrew J. et al. · 2017 · University of Copenhagen · DOI

Full title: Comparison of spectroscopy technologies for improved monitoring of cell culture processes in miniature bioreactors

Authors: Rowland-Jones, Ruth C.; van der Berg, Franciscus Winfried J; Racher, Andrew J.; Martin, Elaine B.; Jaques, Colin

Year: 2017

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/b0ba0d28-f1e5-4abb-be69-231b4094c928

Thesis Evaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration

Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Kumar Ganesan, Saravana et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Evaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration

Authors: Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Kumar Ganesan, Saravana; Martínez-Monje, Iván; Grav, Lise M.; id_orcid 0000-0001-8042-7108; Lavado-García, Jesús; Nielsen, Lars K.

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c72a6084-3783-4f79-b07b-6c0d4b2e6fdb

Thesis Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity

Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity

Authors: Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Kildegaard, Helene Faustrup; Min Lee, Gyun

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b93398cc-7060-452d-87ce-fc9c3bf95dd0

Thesis Engineering death resistance in CHO cells for improved perfusion culture

MacDonald, Michael A.; Nöbel, Matthias; Martínez, Verónica S. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Engineering death resistance in CHO cells for improved perfusion culture

Authors: MacDonald, Michael A.; Nöbel, Matthias; Martínez, Verónica S.; Baker, Kym; Shave, Evan; Gray, Peter P.; Mahler, Stephen; Munro, Trent; Nielsen, Lars K.; Marcellin, Esteban

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ce202b32-0a67-4570-a87a-ab0849f12696

Thesis Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells

Hefzi, Hooman; id_orcid 0009-0003-4067-6224; Martínez-Monge, Iván et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells

Authors: Hefzi, Hooman; id_orcid 0009-0003-4067-6224; Martínez-Monge, Iván; Marin de Mas, Igor; Cowie, Nicholas Luke; Toledo, Alejandro Gomez; Noh, Soo Min; Karottki, Karen Julie la Cour; Decker, Marianne; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Camacho-Zaragoza, Jose Manuel; Kol, Stefan; Schoffelen, Sanne; id_orcid 0000-0003-2664-8561; Pristovšek, Nuša; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Miguez, Antonio A.; Bjørn, Sara Petersen; id_orcid 0000-0003-3341-6160; Brøndum, Karen Kathrine; Javidi, Elham Maria; Jensen, Kristian Lund; Stangl, Laura; Kreidl, Emanuel; Kallehauge, Thomas Beuchert; Ley, Daniel; Ménard, Patrice; Petersen, Helle Munck; Sukhova, Zulfiya; Bauer, Anton; Casanova, Emilio; Barron, Niall; Malmström, Johan; Nielsen, Lars K.; Lee, Gyun Min; Kildegaard, Helene Faustrup; Voldborg, Bjørn G.; id_orcid 0000-0002-7005-1642; Lewis, Nathan E.

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c14c0655-7eef-4331-a9a9-fb44dd376e02

Thesis Improving culture performance and antibody production in CHO cell culture processes by reducing the Warburg effect

Buchsteiner, Maria; Quek, Lake-Ee; Gray, Peter et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Improving culture performance and antibody production in CHO cell culture processes by reducing the Warburg effect

Authors: Buchsteiner, Maria; Quek, Lake-Ee; Gray, Peter; Nielsen, Lars K.

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f0e67f85-4820-447f-988a-01acc4454c93

Thesis Network Reconstruction and In Silico Metabolic Model of Chinese Hamster Ovary cells

Calmels, Cyrielle · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Network Reconstruction and In Silico Metabolic Model of Chinese Hamster Ovary cells

Authors: Calmels, Cyrielle

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e8e79519-7089-44aa-9964-6700b9af9251

Thesis Applying an MPC algorithm to the dissolved oxygen level of an intermittent fed-batch process

Pably, P.; Huusom, J. K.; id_orcid 0000-0002-1367-7235 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Applying an MPC algorithm to the dissolved oxygen level of an intermittent fed-batch process

Authors: Pably, P.; Huusom, J. K.; id_orcid 0000-0002-1367-7235; Kager, J.; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e5bf89bb-2803-4e21-a9e6-46f1fe8b45c3

Thesis Osmolality effects on CHO cell growth, cell volume and antibody productivity and glycosylation

Alhuthali, Sakhr; Kotidis, Pavlos; Kontoravdi, Kleio · 2021 · Imperial College London · DOI

Full title: Osmolality effects on CHO cell growth, cell volume and antibody productivity and glycosylation

Authors: Alhuthali, Sakhr; Kotidis, Pavlos; Kontoravdi, Kleio

Year: 2021

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/88797

Thesis Model-based optimization of antibody galactosylation in CHO cell culture

Kotidis, Pavlos; Jedrzejewski, Philip; Sou, Si Nga et al. · 2019 · Imperial College London · DOI

Full title: Model-based optimization of antibody galactosylation in CHO cell culture

Authors: Kotidis, Pavlos; Jedrzejewski, Philip; Sou, Si Nga; Sellick, Christopher; Polizzi, Karen; Del Val, Ioscani Jimenez; Kontoravdi, Cleo

Year: 2019

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/30802295

Thesis Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch

Gangadharan, Nishanthi · 2023 · University of Cambridge · DOI

Full title: Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch

Authors: Gangadharan, Nishanthi

Year: 2023

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/358135

Thesis Glycosylation Flux Analysis of Immunoglobulin G in Chinese Hamster Ovary Perfusion Cell Culture

Hutter, Sandro; Wolf, Moritz; Papili Gao, Nan et al. · 2018 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Glycosylation Flux Analysis of Immunoglobulin G in Chinese Hamster Ovary Perfusion Cell Culture

Authors: Hutter, Sandro; Wolf, Moritz; Papili Gao, Nan; Lepori, Dario; Schweigler, Thea; Morbidelli, Massimo; Gunawan, Rudiyanto

Year: 2018

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/294344

Thesis In situ FRET Biosensors for the in vivo measurement of important metabolites during cell culture

Behjousiar, Alireza · 2015 · Imperial College London · DOI

Full title: In situ FRET Biosensors for the in vivo measurement of important metabolites during cell culture

Authors: Behjousiar, Alireza

Year: 2015

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/24852

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Process transfer and optimization of Chinese hamster ovary cell cultivation for monoclonal antibody production

Nagraik, Tamanna · 2021

Full title: Process transfer and optimization of Chinese hamster ovary cell cultivation for monoclonal antibody production

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The Biological Impact of High Throughput Continuous Bioprocessing

Sewell, David · 2020

Full title: The Biological Impact of High Throughput Continuous Bioprocessing

Authors: Sewell, David

DOI: https://doi.org/10.17863/cam.58800

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Multi-omics analysis of Chinese hamster ovary cell-based biopharmaceutical production processes

Ali, Amr · 2019

Full title: Multi-omics analysis of Chinese hamster ovary cell-based biopharmaceutical production processes

Authors: Ali, Amr

DOI: https://doi.org/10.17760/d20318588

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Transcriptomic profiling as a tool to characterize CHO cell processes

Sayyari, Abdulaziz Abdullah Al · 2018

Full title: Transcriptomic profiling as a tool to characterize CHO cell processes

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Process intensification for CHO cell biomanufacturing

Schulze, Markus · 2023

Full title: Process intensification for CHO cell biomanufacturing

Authors: Schulze, Markus

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Scale-down of CHO cell fed-batch cultures

Pan, Xiao · 2018

Full title: Scale-down of CHO cell fed-batch cultures

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Hybrid Modelling and Multi- Parametric Control of Bioprocesses

Zahel, Thomas · 2018

Full title: Hybrid Modelling and Multi- Parametric Control of Bioprocesses

Authors: Zahel, Thomas

DOI: https://doi.org/10.3390/books978-3-03842-746-9

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Applications of Machine Learning in Biopharmaceutical Process Development and Manufacturing: Current Trends, Challenges, and Opportunities

Khuat, Thanh Tung; Bassett, Robert; Otte, Ellen et al. · 2023

Full title: Applications of Machine Learning in Biopharmaceutical Process Development and Manufacturing: Current Trends, Challenges, and Opportunities

Authors: Khuat, Thanh Tung; Bassett, Robert; Otte, Ellen; Grevis-James, Alistair; Gabryś, Bogdan

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Impact de la modification du métabolisme primaire des cellules CHO sur leur productivité

Toussaint, Cécile · 2016

Full title: Impact de la modification du métabolisme primaire des cellules CHO sur leur productivité

Authors: Toussaint, Cécile

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When Bioprocess Engineering Meets Machine Learning: A Survey from the Perspective of Automated Bioprocess Development

Duong‐Trung, Nghia; Born, Stefan; Kim, Jong Woo et al. · 2022

Full title: When Bioprocess Engineering Meets Machine Learning: A Survey from the Perspective of Automated Bioprocess Development

DOI: https://doi.org/10.48550/arxiv.2209.01083

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Amélioration de la production et de la qualité des protéines thérapeutiques recombinantes produites en culture en mode cuvée-alimentée de cellules de mammifère

Karengera, Eric · 2017

Full title: Amélioration de la production et de la qualité des protéines thérapeutiques recombinantes produites en culture en mode cuvée-alimentée de cellules de mammifère

Authors: Karengera, Eric

Paper

Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation and ER stress in CHO cells

Sinharoy, Pritam; Aziz, Aaron H.; Majewska, Natalia I. et al. · 2020

Full title: Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation and ER stress in CHO cells

Authors: Sinharoy, Pritam; Aziz, Aaron H.; Majewska, Natalia I.; Ahuja, Sanjeev; Handlogten, Michael W.

DOI: https://doi.org/10.1038/s41598-020-73573-4

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Real-time characterization of mammalian cell culture bioprocesses by magnetic sector MS

Floris, Patrick; Dorival–García, Noemí; Lewis, Graham et al. · 2020

Full title: Real-time characterization of mammalian cell culture bioprocesses by magnetic sector MS

Authors: Floris, Patrick; Dorival–García, Noemí; Lewis, Graham; Josland, G.D.; Merriman, Daniel; Bones, Jonathan

DOI: https://doi.org/10.1039/d0ay01563f

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Systematic data-driven genome-scale metabolic model reduction for dynamic bioprocess modeling: CHO cell culture case study

Richelle, Anne; Antonakoudis, Athanasios · 2025

Full title: Systematic data-driven genome-scale metabolic model reduction for dynamic bioprocess modeling: CHO cell culture case study

Authors: Richelle, Anne; Antonakoudis, Athanasios

DOI: https://doi.org/10.1101/2025.10.02.679947

Paper

Temporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch and Perfusion Bioreactor Operation

Gyorgypal, Aron; Fratz‐Berilla, Erica J.; Kohnhorst, Casey et al. · 2023

Full title: Temporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch and Perfusion Bioreactor Operation

Authors: Gyorgypal, Aron; Fratz‐Berilla, Erica J.; Kohnhorst, Casey; Powers, David N.; Chundawat, Shishir P. S.

DOI: https://doi.org/10.1101/2023.04.15.535602

Paper

Automated Workflow for Instant Labeling and Real-Time Monitoring of Monoclonal Antibody N-Glycosylation

Gyorgypal, Aron; Potter, Oscar G.; Chaturvedi, Antash et al. · 2022

Full title: Automated Workflow for Instant Labeling and Real-Time Monitoring of Monoclonal Antibody N-Glycosylation

Authors: Gyorgypal, Aron; Potter, Oscar G.; Chaturvedi, Antash; Powers, David N.; Chundawat, Shishir P. S.

DOI: https://doi.org/10.1101/2022.12.22.521623

Paper

Overcoming the Limits of Traditional Rate Calculations from Sparse Concentration Data: A Probabilistic Framework for Bioprocess Modeling

Richelle, Anne; Andersson, David Emanuel; Vernersson, Anton et al. · 2025

Full title: Overcoming the Limits of Traditional Rate Calculations from Sparse Concentration Data: A Probabilistic Framework for Bioprocess Modeling

Authors: Richelle, Anne; Andersson, David Emanuel; Vernersson, Anton; Cloarec, Olivier; Trygg, Johan

DOI: https://doi.org/10.1101/2025.09.30.679468

Paper

An Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-linked Glycosylation

Gyorgypal, Aron; Chundawat, Shishir P. S. · 2021

Full title: An Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-linked Glycosylation

Authors: Gyorgypal, Aron; Chundawat, Shishir P. S.

DOI: https://doi.org/10.1101/2021.11.14.468439

Paper

Model-based intensification of CHO cell cultures: one-step strategy from fed-batch to perfusion

Richelle, Anne; Corbett, Brandon; Agarwal, Piyush et al. · 2022

Full title: Model-based intensification of CHO cell cultures: one-step strategy from fed-batch to perfusion

Authors: Richelle, Anne; Corbett, Brandon; Agarwal, Piyush; Vernersson, Anton; Trygg, Johan; McCready, Chris

DOI: https://doi.org/10.1101/2022.05.19.492635

Paper

Debottlenecking and reformulating feed media for improved CHO cell growth and titer by data‐driven and model‐guided analyses

Park, Seo‐Young; Choi, Dong‐Hyuk; Song, Jinsung et al. · 2023

Full title: Debottlenecking and reformulating feed media for improved CHO cell growth and titer by data‐driven and model‐guided analyses

Authors: Park, Seo‐Young; Choi, Dong‐Hyuk; Song, Jinsung; Park, Uiseon; Cho, Hyeran; Hong, Bee Hak; Silberberg, Yaron; Lee, Dong‐Yup

DOI: https://doi.org/10.1002/biot.202300126

Paper

Multi-omic characterization of antibody-producing CHO cell lines elucidates metabolic reprogramming and nutrient uptake bottlenecks

Gopalakrishnan, Saratram; Johnson, William; Valderrama-Gomez, Miguel A. et al. · 2023

Full title: Multi-omic characterization of antibody-producing CHO cell lines elucidates metabolic reprogramming and nutrient uptake bottlenecks

DOI: https://doi.org/10.1101/2023.09.13.557626

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Implementation of Design of Experiments (DOE) for Optimization of Feeding Strategy and Glyco-Engineering of Trastuzumab Biosimilar

Mahboudi, Rasoul; Samavat, Sepideh; Afrah, Amir et al. · 2019

Full title: Implementation of Design of Experiments (DOE) for Optimization of Feeding Strategy and Glyco-Engineering of Trastuzumab Biosimilar

Authors: Mahboudi, Rasoul; Samavat, Sepideh; Afrah, Amir; Khorshidtalab, Mehdi; Tehran, Arezou Fadaei; Motahari, Paria; Sofla, Farnoush Jafari Iri; Maleknia, Shayan

DOI: https://doi.org/10.1101/584144

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Evaluation of the advanced micro-scale bioreactor (ambr™) as a highthroughput tool for cell culture process development

Delouvroy, Frédéric; Révérend, Guillaume Le; Fessler, Boris et al. · 2013

Full title: Evaluation of the advanced micro-scale bioreactor (ambr™) as a highthroughput tool for cell culture process development

Authors: Delouvroy, Frédéric; Révérend, Guillaume Le; Fessler, Boris; Mathy, Grégory; Harmsen, Mareike; Kochanowski, Nadine; Malphettes, Laetitia

DOI: https://doi.org/10.1186/1753-6561-7-s6-p73

Paper

A Hybrid Modeling Framework for Predictive Digital Twins of CHO Cell Culture

Richelle, Anne; Andersson, David Emanuel; Antonakoudis, Athanasios et al. · 2025

Full title: A Hybrid Modeling Framework for Predictive Digital Twins of CHO Cell Culture

Authors: Richelle, Anne; Andersson, David Emanuel; Antonakoudis, Athanasios; Jakobsson, Jesper; Pijeaud, Shanti; Vernersson, Anton; Trygg, Johan

DOI: https://doi.org/10.1101/2025.11.24.690194

Paper

Medium and feed optimization for fed-batch production of a monoclonal antibody in CHO cells

Kochanowski, Nadine; Siriez, Gaetan; Roosens, Sarah et al. · 2011

Full title: Medium and feed optimization for fed-batch production of a monoclonal antibody in CHO cells

Authors: Kochanowski, Nadine; Siriez, Gaetan; Roosens, Sarah; Malphettes, Laetitia

DOI: https://doi.org/10.1186/1753-6561-5-s8-p75

Paper

Identification of performance drivers for an antibody producing CHO-S cell line culture in the Allegro™ XRS 20 single-use bioreactor utilizing historical data

Sanderson, T.; Martino, A.; Wang, Ing-Kae et al. · 2015

Full title: Identification of performance drivers for an antibody producing CHO-S cell line culture in the Allegro™ XRS 20 single-use bioreactor utilizing historical data

Authors: Sanderson, T.; Martino, A.; Wang, Ing-Kae; Rose, Amanda; Rees, Byron; Bradbury, Lisa

DOI: https://doi.org/10.1186/1753-6561-9-s9-p33

Paper

Understanding and Controlling Sialylation in a CHO Fc-Fusion Process

Lewis, Amanda M.; Croughan, William D.; Aranı́bar, Nelly et al. · 2016

Full title: Understanding and Controlling Sialylation in a CHO Fc-Fusion Process

DOI: https://doi.org/10.1371/journal.pone.0157111

Paper

In Situ Monitoring of Intracellular Glucose and Glutamine in CHO Cell Culture

Behjousiar, Alireza; Kontoravdi, Cleo; Polizzi, Karen M. · 2012

Full title: In Situ Monitoring of Intracellular Glucose and Glutamine in CHO Cell Culture

Authors: Behjousiar, Alireza; Kontoravdi, Cleo; Polizzi, Karen M.

DOI: https://doi.org/10.1371/journal.pone.0034512

Paper

Integrating real-time OUR monitoring with adaptive feeding for enhanced antibody production

Zhang, Xinran; Ran, Qingyuan; Zhang, Botao et al. · 2025

Full title: Integrating real-time OUR monitoring with adaptive feeding for enhanced antibody production

Authors: Zhang, Xinran; Ran, Qingyuan; Zhang, Botao; He, Yongmei; Zhao, Liang; Tan, Wen‐Song; Ye, Qian

DOI: https://doi.org/10.1186/s40643-025-00961-x

Paper

The successful transfer of a modern CHO fed-batch process to different single-use bioreactors

Ruhl, S. F.; Husemann, Ute; Jurkiewicz, Elke et al. · 2013

Full title: The successful transfer of a modern CHO fed-batch process to different single-use bioreactors

Authors: Ruhl, S. F.; Husemann, Ute; Jurkiewicz, Elke; Dreher, Thomas; Greller, Gerhard

DOI: https://doi.org/10.1186/1753-6561-7-s6-p32

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Deciphering Metabolic Pathways in High Seeding Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective

Bokelmann, Carolin; Ehsani, Alireza; Schaub, Jochen et al. · 2024

Full title: Deciphering Metabolic Pathways in High Seeding Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective

Authors: Bokelmann, Carolin; Ehsani, Alireza; Schaub, Jochen; Stiefel, Fabian

DOI: https://doi.org/10.20944/preprints202402.1474.v1

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From Shallow to Deep Bioprocess Hybrid Modeling: Advances and Future Perspectives

Agharafeie, Roshanak; Ramos, João R. C.; Mendes, Jorge M. et al. · 2023

Full title: From Shallow to Deep Bioprocess Hybrid Modeling: Advances and Future Perspectives

Authors: Agharafeie, Roshanak; Ramos, João R. C.; Mendes, Jorge M.; Oliveira, Rui

DOI: https://doi.org/10.3390/fermentation9100922

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Process Mapping and Optimization Study of CHO Cell Cultures for mAb Production using Ambr® 250 High-throughput Parallel Bioreactors

Bordoloi, Achinta; Talebnia, Farid · 2025

Full title: Process Mapping and Optimization Study of CHO Cell Cultures for mAb Production using Ambr® 250 High-throughput Parallel Bioreactors

Authors: Bordoloi, Achinta; Talebnia, Farid

DOI: https://doi.org/10.21203/rs.3.rs-6831589/v1

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Self-Driving Development of Perfusion Processes for Monoclonal Antibody Production

Müller, Claudio; Vuillemin, Thomas; Gadiyar, Chethana Janardhana et al. · 2024

Full title: Self-Driving Development of Perfusion Processes for Monoclonal Antibody Production

DOI: https://doi.org/10.32388/xufb08

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Boosting Productivity for Advanced Biomanufacturing by Re-Using Viable Cells

Reger, Lucas Nik; Saballus, Martin; Matuszczyk, Jens et al. · 2023

Full title: Boosting Productivity for Advanced Biomanufacturing by Re-Using Viable Cells

Authors: Reger, Lucas Nik; Saballus, Martin; Matuszczyk, Jens; Kampmann, Markus; Wijffels, René H.; Martens, Dirk E.; Niemann, Julia

DOI: https://doi.org/10.3389/fbioe.2023.1106292

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Engineering protein glycosylation in CHO cells to be highly similar to murine host cells

Gupta, Shivani; Shah, Bhavana; Fung, Coral Shek et al. · 2023

Full title: Engineering protein glycosylation in CHO cells to be highly similar to murine host cells

Authors: Gupta, Shivani; Shah, Bhavana; Fung, Coral Shek; Chan, Pik K.; Wakefield, Devin L.; Kuhns, Scott; Goudar, Chetan T.; Piret, James M.

DOI: https://doi.org/10.3389/fbioe.2023.1113994

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Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments

Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald et al. · 2021

Full title: Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments

Authors: Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald; Sissolak, Bernhard

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Reger, Lucas Nik; Saballus, Martin; Kappes, Annika et al. · 2023

Full title: A novel hybrid bioprocess strategy addressing key challenges of advanced biomanufacturing

Authors: Reger, Lucas Nik; Saballus, Martin; Kappes, Annika; Kampmann, Markus; Wijffels, René H.; Martens, Dirk E.; Niemann, Julia

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Cell specific perfusion rates drive growth dynamics and metabolism in CHO N-1 perfusion processes independent of perfusion rate control method

Walther, Julia; Costa, Tiago Ribeiro da; Winkler, Lydia et al. · 2025

Full title: Cell specific perfusion rates drive growth dynamics and metabolism in CHO N-1 perfusion processes independent of perfusion rate control method

Authors: Walther, Julia; Costa, Tiago Ribeiro da; Winkler, Lydia; Schaub, Jochen; Habicher, Tobias

DOI: https://doi.org/10.3389/fbioe.2025.1608889

Paper

Modulating antibody N-glycosylation through feed additives using a multi-tiered approach

Kranjc, Jaka; Kramer, Lovro; Mikelj, Miha et al. · 2024

Full title: Modulating antibody N-glycosylation through feed additives using a multi-tiered approach

Authors: Kranjc, Jaka; Kramer, Lovro; Mikelj, Miha; Anderluh, Marko; Pišlar, Anja; Brinc, Matjaž

DOI: https://doi.org/10.3389/fbioe.2024.1448925

Paper

Bioprocess feeding optimization through in silico dynamic experiments and hybrid digital models—a proof of concept

Barberi, Gianmarco; Giacopuzzi, Christian; Facco, Pierantonio · 2024

Full title: Bioprocess feeding optimization through in silico dynamic experiments and hybrid digital models—a proof of concept

Authors: Barberi, Gianmarco; Giacopuzzi, Christian; Facco, Pierantonio

DOI: https://doi.org/10.3389/fceng.2024.1456402

Paper

Navigating industry 4.0 and 5.0: the role of hybrid modelling in (bio)chemical engineering’s digital transition

Gargalo, Carina L.; Malanca, Alina Anamaria; Aouichaoui, Adem R.N. et al. · 2024

Full title: Navigating industry 4.0 and 5.0: the role of hybrid modelling in (bio)chemical engineering’s digital transition

Authors: Gargalo, Carina L.; Malanca, Alina Anamaria; Aouichaoui, Adem R.N.; Huusom, Jakob Kjøbsted; Gernaey, Krist V.

DOI: https://doi.org/10.3389/fceng.2024.1494244

Paper

Hybrid modeling for biopharmaceutical processes: advantages, opportunities, and implementation

Narayanan, Harini; Stosch, Moritz von; Feidl, Fabian et al. · 2023

Full title: Hybrid modeling for biopharmaceutical processes: advantages, opportunities, and implementation

Authors: Narayanan, Harini; Stosch, Moritz von; Feidl, Fabian; Sokolov, Michael; Morbidelli, Massimo; Butté, Alessandro

DOI: https://doi.org/10.3389/fceng.2023.1157889

Paper

Design ideas behind Bioprocess Library for Modelica

Axelsson, Jan Peter · 2024

Full title: Design ideas behind Bioprocess Library for Modelica

Authors: Axelsson, Jan Peter

DOI: https://doi.org/10.3384/ecp204453

Paper

Cell clone selection-impact of operation modes and medium exchange strategies on clone ranking.

Dorn, Marie; Ferng, Christine; Klottrup-Rees, Kerensa et al. · 2024

Full title: Cell clone selection-impact of operation modes and medium exchange strategies on clone ranking.

Authors: Dorn, Marie; Ferng, Christine; Klottrup-Rees, Kerensa; Lee, Kenneth; Micheletti, Martina

DOI: https://doi.org/10.3389/fbioe.2024.1479633

Paper

Boost dynamic protocols for producing mammalian biopharmaceuticals with intensified DoE—a practical guide to analyses with OLS and hybrid modeling

Nold, Verena; Junghans, Lisa; Bayer, Benjamin et al. · 2023

Full title: Boost dynamic protocols for producing mammalian biopharmaceuticals with intensified DoE—a practical guide to analyses with OLS and hybrid modeling

Authors: Nold, Verena; Junghans, Lisa; Bayer, Benjamin; Bisgen, Lorenzo; Duerkop, Mark; Drerup, Raphael; Presser, Beate; Schwab, Thomas; Bluhmki, Erich; Wieschalka, Stefan; Knapp, Bettina L.

DOI: https://doi.org/10.3389/fceng.2022.1044245

Paper

Strategies Used in Manufacturing Processes to Drive and Control Mammalian Cells to Undergo a Lactate Metabolic Shift

Muralidharan, Naveenganesh; Bolduc, Emma; Davis, Mark · 2024

Full title: Strategies Used in Manufacturing Processes to Drive and Control Mammalian Cells to Undergo a Lactate Metabolic Shift

Authors: Muralidharan, Naveenganesh; Bolduc, Emma; Davis, Mark

DOI: https://doi.org/10.36468/pharmaceutical-sciences.129314

Paper

Model-Based Design of Process Strategies for Cell Culture Bioprocesses: State of the Art and New Perspectives

Möller, Johannes; Pörtner, Ralf · 2017

Full title: Model-Based Design of Process Strategies for Cell Culture Bioprocesses: State of the Art and New Perspectives

Authors: Möller, Johannes; Pörtner, Ralf

DOI: https://doi.org/10.5772/67600

Paper

Dynamic Optimization of Bioprocesses

Koumpouras, George; Kontoravdi, Cleo · 2012

Full title: Dynamic Optimization of Bioprocesses

Authors: Koumpouras, George; Kontoravdi, Cleo

DOI: https://doi.org/10.4236/am.2012.330208

Paper

The Effect of Hyper-Osmotic Conditions on the Growth, Metabolism, and Specific Antibody Productivity of a GS-NS0 Cell Line

Brady, Stefanie Ellen · 2009

Full title: The Effect of Hyper-Osmotic Conditions on the Growth, Metabolism, and Specific Antibody Productivity of a GS-NS0 Cell Line

Authors: Brady, Stefanie Ellen

Paper

A control strategy to investigate the relationship between specific productivity and high-mannose glycoforms in CHO cells

Zalai, Dénes; Hevér, Helga; Lovász, Krisztina et al. · 2016

Full title: A control strategy to investigate the relationship between specific productivity and high-mannose glycoforms in CHO cells

Authors: Zalai, Dénes; Hevér, Helga; Lovász, Krisztina; Molnár, Dóra; Wechselberger, Patrick; Hofer, Alexandra; Párta, László; Putics, Ákos; Herwig, Christoph

DOI: https://doi.org/10.1007/s00253-016-7380-4

Paper

Metabolic characterization of a CHO cell size increase phase in fed-batch cultures

Pan, Xiao; Dalm, Ciska; Wijffels, René H. et al. · 2017

Full title: Metabolic characterization of a CHO cell size increase phase in fed-batch cultures

Authors: Pan, Xiao; Dalm, Ciska; Wijffels, René H.; Martens, Dirk E.

DOI: https://doi.org/10.1007/s00253-017-8531-y

Paper

Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing

Esmonde‐White, Karen A.; Cuellar, Maryann; Uerpmann, Carsten et al. · 2016

Full title: Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing

Authors: Esmonde‐White, Karen A.; Cuellar, Maryann; Uerpmann, Carsten; Lenain, Bruno; Lewis, Ian R.

DOI: https://doi.org/10.1007/s00216-016-9824-1

Paper

Single compound data supplementation to enhance transferability of fermentation specific Raman spectroscopy models

Klaverdijk, Maarten; Ottens, Marcel; Klijn, Marieke E. · 2025

Full title: Single compound data supplementation to enhance transferability of fermentation specific Raman spectroscopy models

Authors: Klaverdijk, Maarten; Ottens, Marcel; Klijn, Marieke E.

DOI: https://doi.org/10.1007/s00216-025-05768-5

Paper

Applications of off-gas mass spectrometry in fed-batch mammalian cell culture

Goh, Hai‐Yuan; Sulu, Michael; Alosert, Haneen et al. · 2019

Full title: Applications of off-gas mass spectrometry in fed-batch mammalian cell culture

Authors: Goh, Hai‐Yuan; Sulu, Michael; Alosert, Haneen; Lewis, Graham; Josland, G.D.; Merriman, Daniel

DOI: https://doi.org/10.1007/s00449-019-02242-2

Paper

Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors

Metze, Sabrina; Ruhl, S. F.; Greller, Gerhard et al. · 2019

Full title: Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors

Authors: Metze, Sabrina; Ruhl, S. F.; Greller, Gerhard; Grimm, C.; Scholz, Judith

DOI: https://doi.org/10.1007/s00449-019-02216-4

Paper

Pre-stage perfusion and ultra-high seeding cell density in CHO fed-batch culture: a case study for process intensification guided by systems biotechnology

Stepper, Lisa; Filser, Florian Alois; Fischer, Simon et al. · 2020

Full title: Pre-stage perfusion and ultra-high seeding cell density in CHO fed-batch culture: a case study for process intensification guided by systems biotechnology

Authors: Stepper, Lisa; Filser, Florian Alois; Fischer, Simon; Schaub, Jochen; Gorr, Ingo H.; Voges, Raphael

DOI: https://doi.org/10.1007/s00449-020-02337-1

Paper

Hyperosmolality in CHO cell culture: effects on the proteome

Romanova, Nadiya; Schelletter, Louise; Hoffrogge, Raimund et al. · 2022

Full title: Hyperosmolality in CHO cell culture: effects on the proteome

Authors: Romanova, Nadiya; Schelletter, Louise; Hoffrogge, Raimund; Noll, Thomas

DOI: https://doi.org/10.1007/s00253-022-11861-x

Paper

Exploring metabolic effects of dipeptide feed media on CHO cell cultures by in silico model-guided flux analysis

Park, Seo‐Young; Song, Jinsung; Choi, Dong‐Hyuk et al. · 2024

Full title: Exploring metabolic effects of dipeptide feed media on CHO cell cultures by in silico model-guided flux analysis

Authors: Park, Seo‐Young; Song, Jinsung; Choi, Dong‐Hyuk; Park, Uiseon; Cho, Hyeran; Hong, Bee Hak; Silberberg, Yaron; Lee, Dong‐Yup

DOI: https://doi.org/10.1007/s00253-023-12997-0

Paper

Exploring the limits of conventional small-scale CHO fed-batch for accelerated on demand monoclonal antibody production

Mahé, Amélie; Martiné, Alexandra; Fagète, Séverine et al. · 2021

Full title: Exploring the limits of conventional small-scale CHO fed-batch for accelerated on demand monoclonal antibody production

Authors: Mahé, Amélie; Martiné, Alexandra; Fagète, Séverine; Girod, Pierre‐Alain

DOI: https://doi.org/10.1007/s00449-021-02657-w

Paper

A simple method to determine evaporation and compensate for liquid losses in small-scale cell culture systems

Wiegmann, Vincent; Martinez, Cristina Bernal; Baganz, Frank · 2018

Full title: A simple method to determine evaporation and compensate for liquid losses in small-scale cell culture systems

Authors: Wiegmann, Vincent; Martinez, Cristina Bernal; Baganz, Frank

DOI: https://doi.org/10.1007/s10529-018-2556-x

Paper

Genome-scale modeling of Chinese hamster ovary cells by hybrid semi-parametric flux balance analysis

Ramos, João R. C.; Poiares‐Oliveira, Gil; Dumas, Patrick et al. · 2022

Full title: Genome-scale modeling of Chinese hamster ovary cells by hybrid semi-parametric flux balance analysis

Authors: Ramos, João R. C.; Poiares‐Oliveira, Gil; Dumas, Patrick; Oliveira, Rui

DOI: https://doi.org/10.1007/s00449-022-02795-9

Paper

Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins

Wolnick, Nicolas; Dickson, Marissa; Webster, Thaddaeus A. et al. · 2024

Full title: Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins

DOI: https://doi.org/10.1007/s00449-024-02997-3

Paper

Selection of chemically defined media for CHO cell fed-batch culture processes

Pan, Xiao; Streefland, Mathieu; Dalm, Ciska et al. · 2016

Full title: Selection of chemically defined media for CHO cell fed-batch culture processes

Authors: Pan, Xiao; Streefland, Mathieu; Dalm, Ciska; Wijffels, René H.; Martens, Dirk E.

DOI: https://doi.org/10.1007/s10616-016-0036-5

Paper

Effects of process intensification on homogeneity of an IgG1:κ monoclonal antibody during perfusion culture

Liang, George H.; Madhavarao, Chikkathur N.; Morris, Caitlin et al. · 2024

Full title: Effects of process intensification on homogeneity of an IgG1:κ monoclonal antibody during perfusion culture

Authors: Liang, George H.; Madhavarao, Chikkathur N.; Morris, Caitlin; O'Connor, T; Ashraf, Muhammad; Yoon, Seongkyu

DOI: https://doi.org/10.1007/s00253-024-13110-9

Thesis

Improvement of xylanase production by recombinant Escherichia coli DH5α using fed-batch fermentation

Basar, Bazilah · 2011

Full title: Improvement of xylanase production by recombinant Escherichia coli DH5α using fed-batch fermentation

Authors: Basar, Bazilah

DOI: http://psasir.upm.edu.my/id/eprint/27361/1/FBSB%202011%2047R.pdf

Thesis

Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Zhang, Liang · 2020

Full title: Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Authors: Zhang, Liang

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-273343

Thesis

Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production

Monsalve-Bravo, Gloria M; Garelli, Fabricio; Mozumder, Salatul Islam et al. · 2015

Full title: Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production

Authors: Monsalve-Bravo, Gloria M; Garelli, Fabricio; Mozumder, Salatul Islam; Alvarez, Hernan; De Battista, Hernán

DOI: http://sedici.unlp.edu.ar/handle/10915/134699

Thesis

Global stabilisation of continuous bioreactors: tools for analysis and design of feeding laws

De Battista, Hernán; Jamilis Ricaldoni, Martín Ignacio; Garelli, Fabricio et al. · 2018

Full title: Global stabilisation of continuous bioreactors: tools for analysis and design of feeding laws

Authors: De Battista, Hernán; Jamilis Ricaldoni, Martín Ignacio; Garelli, Fabricio; Picó, Jesús

DOI: http://sedici.unlp.edu.ar/handle/10915/124891

Thesis

Enhancement of Lipid Production in Rhodosporidium toruloides: Designing Feeding Strategies Through Dynamic Flux Balance Analysis

Castañeda, María Teresita; Nuñez, Sebastián; Jamilis Ricaldoni, Martín Ignacio et al. · 2025

Full title: Enhancement of Lipid Production in Rhodosporidium toruloides: Designing Feeding Strategies Through Dynamic Flux Balance Analysis

Authors: Castañeda, María Teresita; Nuñez, Sebastián; Jamilis Ricaldoni, Martín Ignacio; De Battista, Hernán

DOI: http://sedici.unlp.edu.ar/handle/10915/189167

Thesis

Reaction rate reconstruction from biomass concentration measurement in bioreactors using modified second-order sliding mode algorithms

De Battista, Hernán; Picó, Jesús; Garelli, Fabricio et al. · 2012

Full title: Reaction rate reconstruction from biomass concentration measurement in bioreactors using modified second-order sliding mode algorithms

Authors: De Battista, Hernán; Picó, Jesús; Garelli, Fabricio; Navarro, J. L.

DOI: http://sedici.unlp.edu.ar/handle/10915/123847

Thesis

Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Murayyan, Abdulmonem · 2013

Full title: Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Authors: Murayyan, Abdulmonem

DOI: http://hdl.handle.net/10214/6604

Thesis

Macroscopic models of Chinese hamster ovary cell cultures

Hagrot, Erika · 2019

Full title: Macroscopic models of Chinese hamster ovary cell cultures

Authors: Hagrot, Erika

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-262850

Thesis

Optical in-line biosensor for long-term continuous glucose monitoring and control in cell culture

Tric, Mircea · 2017

Full title: Optical in-line biosensor for long-term continuous glucose monitoring and control in cell culture

Authors: Tric, Mircea

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/23763/1/Dissertation%20Mircea%20Tric.pdf

Thesis

The Assessment of MAb Quality and Quantity

Drouillard, Gerald · 2015

Full title: The Assessment of MAb Quality and Quantity

Authors: Drouillard, Gerald

DOI: http://hdl.handle.net/10214/8743

Thesis

Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis

Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Hong, Moo Sun · 2022

Full title: Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Authors: Hong, Moo Sun

DOI: https://hdl.handle.net/1721.1/138943

Thesis

Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Maloney, Andrew John · 2025

Full title: Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Authors: Maloney, Andrew John

DOI: https://hdl.handle.net/1721.1/158315

Thesis

Recycling and Regeneration of Spent Perfusion Media via Ion Concentration Polarization

Wynne, Eric Michael · 2025

Full title: Recycling and Regeneration of Spent Perfusion Media via Ion Concentration Polarization

Authors: Wynne, Eric Michael

DOI: https://hdl.handle.net/1721.1/164151

Thesis

Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays

Rohskopf, Zhumei · 2023

Full title: Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays

Authors: Rohskopf, Zhumei

DOI: https://hdl.handle.net/1721.1/152457

Thesis

Characterization of the down regulation of antibody production in high cell density perfusion culture

Morrill, Joyce Catherine · 2006

Full title: Characterization of the down regulation of antibody production in high cell density perfusion culture

Authors: Morrill, Joyce Catherine

DOI: http://hdl.handle.net/1721.1/32602

Thesis

Modeling, simulation and dynamic otpimization applied to an ethanol fed-batch fermentation process

Siqueira, Adriano Almeida Gonçalves · 2013

Full title: Modeling, simulation and dynamic otpimization applied to an ethanol fed-batch fermentation process

Authors: Siqueira, Adriano Almeida Gonçalves

DOI: http://abcm.org.br/anais/cobem/2013/PDF/2058.pdf

Thesis

Enhancing mammalian bioprocessing through engineering Chinese hamster ovary cell metabolism

Hefzi, Hooman · 2018

Full title: Enhancing mammalian bioprocessing through engineering Chinese hamster ovary cell metabolism

Authors: Hefzi, Hooman

DOI: https://escholarship.org/uc/item/91h2z79t

Thesis

The influence of glucose metabolism on high cell density fermentation /

Luli, Gregory William · 1988

Full title: The influence of glucose metabolism on high cell density fermentation /

Authors: Luli, Gregory William

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1487594970651618

Thesis

Engineering Oxidative Stress Resistance in CHO Cell Factories

Fairbrass, Danielle L · 2016

Full title: Engineering Oxidative Stress Resistance in CHO Cell Factories

Authors: Fairbrass, Danielle L

DOI: https://etheses.whiterose.ac.uk/id/eprint/16227/1/Master_Copy_DLFairbrassThesis.pdf

Thesis

Quantitative Analysis of Proteome Dynamics in Chinese Hamster Ovary cells

Florczak, Beata D · 2019

Full title: Quantitative Analysis of Proteome Dynamics in Chinese Hamster Ovary cells

Authors: Florczak, Beata D

DOI: https://etheses.whiterose.ac.uk/id/eprint/25823/1/B.Florczak_thesis.pdf

Thesis

Evaluation and characterisation of phenotypic heterogeneity in Chinese Hamster Ovary cell populations during long-term culture

Fernandez Martell, Alejandro · 2015

Full title: Evaluation and characterisation of phenotypic heterogeneity in Chinese Hamster Ovary cell populations during long-term culture

Authors: Fernandez Martell, Alejandro

DOI: https://etheses.whiterose.ac.uk/id/eprint/9152/7/PhD%20thesis%20Alejandro%20Fernandez%20Martell%20%28final%20version%29.pdf

Thesis

Development of an integrated platform for the production of recombinant biopharmaceuticals

Segarra, Camille · 2013

Full title: Development of an integrated platform for the production of recombinant biopharmaceuticals

Authors: Segarra, Camille

DOI: https://etheses.whiterose.ac.uk/id/eprint/4147/1/Segarra_Thesis_PostCorrections.pdf

Thesis

Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

Zagari, Francesca · 2012

Full title: Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

Authors: Zagari, Francesca

DOI: https://infoscience.epfl.ch/handle/20.500.14299/84627

Thesis

Influence of cell-line and process conditions on the glycosylation of recombinant proteins

Nahrgang, Stefan · 2005

Full title: Influence of cell-line and process conditions on the glycosylation of recombinant proteins

Authors: Nahrgang, Stefan

DOI: https://infoscience.epfl.ch/handle/20.500.14299/211632

Thesis

ELUCIDATING MAMMALIAN CELL METABOLISM USING ‘OMICS TO ENHANCE BIOPROCESS CAPABILITIES

Dhara, Venkata Gayatri · 2022

Full title: ELUCIDATING MAMMALIAN CELL METABOLISM USING ‘OMICS TO ENHANCE BIOPROCESS CAPABILITIES

Authors: Dhara, Venkata Gayatri

DOI: http://jhir.library.jhu.edu/handle/1774.2/66775

Thesis

Predictive models for upstream mammalian cell culture development: a review

Yatipanthalawa, BS; Gras, SL · 2023

Full title: Predictive models for upstream mammalian cell culture development: a review

Authors: Yatipanthalawa, BS; Gras, SL

DOI: https://hdl.handle.net/11343/339523

Thesis

Extremum-Seeking Control of Industrial-Scale Fermentation Processes

Johnsson, Ola · 2013

Full title: Extremum-Seeking Control of Industrial-Scale Fermentation Processes

Authors: Johnsson, Ola

DOI: https://lup.lub.lu.se/record/4065043

Thesis

Probing Control : Analysis and Design with Application to Fed-Batch Bioreactors

Velut, Stéphane · 2005

Full title: Probing Control : Analysis and Design with Application to Fed-Batch Bioreactors

Authors: Velut, Stéphane

DOI: https://lup.lub.lu.se/record/24605

Thesis

Probing Control in B. licheniformis Fermentations

Johnsson, Ola · 2010

Full title: Probing Control in B. licheniformis Fermentations

Authors: Johnsson, Ola

DOI: http://lup.lub.lu.se/student-papers/record/8847429

Thesis

Probing Control of Glucose Feeding in Escherichia coli Cultivations

Åkesson, Mats · 1999

Full title: Probing Control of Glucose Feeding in Escherichia coli Cultivations

Authors: Åkesson, Mats

DOI: https://lup.lub.lu.se/record/40163

Thesis

Impact de la modification du métabolisme primaire des cellules CHO sur leur productivité

Toussaint, Cecile · 2017

Full title: Impact de la modification du métabolisme primaire des cellules CHO sur leur productivité

Authors: Toussaint, Cecile

DOI: http://hdl.handle.net/1866/18549

Thesis

Recombinant protein production utilising a metallothionein expression system and a Super-CHO cell line

Huang, Edwin P.C. · 2006

Full title: Recombinant protein production utilising a metallothionein expression system and a Super-CHO cell line

Authors: Huang, Edwin P.C.

DOI: http://hdl.handle.net/1959.4/24940

Thesis

High cell density mammalian cell fermentation

Jirasripongpun, Kalyanee · 1992

Full title: High cell density mammalian cell fermentation

Authors: Jirasripongpun, Kalyanee

DOI: http://hdl.handle.net/1959.4/68130

Thesis

Appendix for: "Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch"

Gangadharan, Nishanthi · 2023

Full title: Appendix for: "Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch"

Authors: Gangadharan, Nishanthi

DOI: https://www.repository.cam.ac.uk/handle/1810/347248

Thesis

The Biological Impact of High Throughput Continuous Bioprocessing

Sewell, David John · 2020

Full title: The Biological Impact of High Throughput Continuous Bioprocessing

Authors: Sewell, David John

DOI: https://www.repository.cam.ac.uk/handle/1810/311711

Thesis

Study and characterisation of human HEK293 cell line as a platform for recombinant protein production

Liste Calleja, Leticia · 2015

Full title: Study and characterisation of human HEK293 cell line as a platform for recombinant protein production

Authors: Liste Calleja, Leticia

DOI: http://hdl.handle.net/10803/308324

Thesis

Effect of adenosine and cordycepin on recombinant antibody production yields in two different Chinease hamster ovary cell lines

Jarusintanakorn, Salinthip; Rangnoi, Kuntalee; Yamabhai, Montarop et al. · 2024

Full title: Effect of adenosine and cordycepin on recombinant antibody production yields in two different Chinease hamster ovary cell lines

Authors: Jarusintanakorn, Salinthip; Rangnoi, Kuntalee; Yamabhai, Montarop; Mastrobattista, Enrico

DOI: https://dspace.library.uu.nl/handle/1874/438035

Thesis

Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe et al. · 2016

Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

Authors: López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe; Carrillo-Cocom, Leydi Maribel; Rocha-Pizaña, María del Refugio; Alvarez, Mario Moises

DOI: http://hdl.handle.net/1721.1/105504

Thesis

Development of a protein-free fed-batch process for NS0 cells: studies on regulation of proliferation

Spens, Erika · 2006

Full title: Development of a protein-free fed-batch process for NS0 cells: studies on regulation of proliferation

Authors: Spens, Erika

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4162

Thesis

Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

Sumit, Madhuresh; Dolatshahi, Sepideh; Chu, An-Hsiang Adam et al. · 2020

Full title: Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

DOI: https://hdl.handle.net/1721.1/125974

Thesis

Continuous Online Protein Quality Monitoring during Perfusion Culture Production Using an Integrated Micro/Nanofluidic System

Kwon, Taehong; Ko, Sung Hee; Hamel, Jean-Francois P et al. · 2020

Full title: Continuous Online Protein Quality Monitoring during Perfusion Culture Production Using an Integrated Micro/Nanofluidic System

Authors: Kwon, Taehong; Ko, Sung Hee; Hamel, Jean-Francois P; Han, Jongyoon

DOI: https://hdl.handle.net/1721.1/125538

Thesis

Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia et al. · 2012

Full title: Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76323

Thesis

Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells

Davami, Fatemeh; Baldi, Lucia; Rajendra, Yashas et al. · 2014

Full title: Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells

Authors: Davami, Fatemeh; Baldi, Lucia; Rajendra, Yashas; M Wurm, Florian

DOI: https://infoscience.epfl.ch/handle/20.500.14299/108905

Thesis

An Optimal Operating Strategy for Fed-Batch Fermentations by Feeding the Overflow Metabolite

Valentinotti, S.; Cannizzaro, C.; Srinivasan, B. et al. · 2004

Full title: An Optimal Operating Strategy for Fed-Batch Fermentations by Feeding the Overflow Metabolite

Authors: Valentinotti, S.; Cannizzaro, C.; Srinivasan, B.; Bonvin, D.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/176669

Thesis

Optimal Control of Fed-Batch Fermenters

Valentinotti, S.; Cannizzaro, C.; Rhiel, M. et al. · 2004

Full title: Optimal Control of Fed-Batch Fermenters

Authors: Valentinotti, S.; Cannizzaro, C.; Rhiel, M.; Holmberg, U.; von Stockar, U.; Bonvin, D.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/175476

Thesis

Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells

Meuwly, F.; von Stockar, U.; Kadouri, A. · 2006

Full title: Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells

Authors: Meuwly, F.; von Stockar, U.; Kadouri, A.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226104

Thesis

Evaluation of an online biomass probe to monitor cell growth and cell death.

Perani, A; Gloria, B; Wang, D et al. · 2022

Full title: Evaluation of an online biomass probe to monitor cell growth and cell death.

Authors: Perani, A; Gloria, B; Wang, D; Buffier, A-S; Berteau, O; Esteban, G; Smyth, FE; Scott, AM

DOI: https://hdl.handle.net/11343/303929

Thesis

Impact on product quality of high productive GS-CHO cell lines.

Perani, A; Gloria, B; Wang, D et al. · 2022

Full title: Impact on product quality of high productive GS-CHO cell lines.

Authors: Perani, A; Gloria, B; Wang, D; Murphy, R; Singh, HK; Smyth, FE; Scott, AM

DOI: https://hdl.handle.net/11343/303930

Thesis

Biomass soft sensor for a Pichia pastoris fed‐batch process based on phase detection and hybrid modeling

Brunner, Vincent; Siegl, Manuel; Geier, Dominik et al. · 2020

Full title: Biomass soft sensor for a Pichia pastoris fed‐batch process based on phase detection and hybrid modeling

Authors: Brunner, Vincent;Siegl, Manuel;Geier, Dominik;Becker, Thomas

DOI: https://mediatum.ub.tum.de/1576014

Thesis

High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

Zhang, Ye · 2017

Full title: High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

Authors: Zhang, Ye

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-207600

Thesis

Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.

Traustason, Bergthor; Cheeks, Matthew; Dikicioglu, Duygu · 2020

Full title: Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.

Authors: Traustason, Bergthor; Cheeks, Matthew; Dikicioglu, Duygu

DOI: https://www.repository.cam.ac.uk/handle/1810/301284

Thesis

Preemptive variation reduction in biologic drug substance manufacturing

Güereca Valdivia, Ismael · 2024

Full title: Preemptive variation reduction in biologic drug substance manufacturing

Authors: Güereca Valdivia, Ismael

DOI: https://hdl.handle.net/1721.1/155982

Thesis

Probing Control of Glucose Feeding in Cultivation of Saccharomyces cerevisiae

Fredriksson, John · 2001

Full title: Probing Control of Glucose Feeding in Cultivation of Saccharomyces cerevisiae

Authors: Fredriksson, John

DOI: http://lup.lub.lu.se/student-papers/record/8848220

Thesis

Development of tools for monitoring and controlling cell cultures through the metabolic analysis

Martínez Monge, Iván · 2018

Full title: Development of tools for monitoring and controlling cell cultures through the metabolic analysis

Authors: Martínez Monge, Iván

DOI: http://hdl.handle.net/10803/664350

Thesis

Increasing biomass production in bioreactors applying metabolic analysis and engineering tools

Comas Sanchez, Pere · 2021

Full title: Increasing biomass production in bioreactors applying metabolic analysis and engineering tools

Authors: Comas Sanchez, Pere

DOI: http://hdl.handle.net/10803/671074

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Fed Batch Feeding Strategies For Cho Cell Cultures

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