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Optimal Conditions For Aav Vector Production In He

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Paper Optimization of lentiviral vector production for scale-up in fixed-bed bioreactor

Valkama, Anniina J.; Leinonen, Hanna; Lipponen, Eevi M. et al. · 2017 · Gene Therapy · DOI

Full title: Optimization of lentiviral vector production for scale-up in fixed-bed bioreactor

Authors: Valkama, Anniina J.; Leinonen, Hanna; Lipponen, Eevi M.; Turkki, Vesa; Malinen, Jukka; Heikura, Tommi; Ylä‐Herttuala, Seppo; Lesch, Hanna P.

Year: 2017

Venue: Gene Therapy

DOI: https://doi.org/10.1038/gt.2017.91

Paper Analytical characterization of full, intermediate, and empty AAV capsids.

McColl-Carboni, Aisleen; Dollive, Serena; Laughlin, Sarah et al. · 2024 · Gene therapy · DOI

Full title: Analytical characterization of full, intermediate, and empty AAV capsids.

Authors: McColl-Carboni, Aisleen; Dollive, Serena; Laughlin, Sarah; Lushi, Rudenc; MacArthur, Michael; Zhou, Shanshan; Gagnon, Jeffrey; Smith, Christopher A; Burnham, Brenda; Horton, Robert; Lata, Dimpal; Uga, Brianna; Natu, Kalyani; Michel, Emmanuela; Slater, Celia; DaSilva, Evan; Bruccoleri, Robert; Kelly, Tim; McGivney, James B

Year: 2024

Venue: Gene therapy

DOI: https://doi.org/10.1038/s41434-024-00444-2

Paper Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington's disease.

Wu, Zheng; Parry, Matthew; Hou, Xiao-Yi et al. · 2020 · Nature communications · DOI

Full title: Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington's disease.

Authors: Wu, Zheng; Parry, Matthew; Hou, Xiao-Yi; Liu, Min-Hui; Wang, Hui; Cain, Rachel; Pei, Zi-Fei; Chen, Yu-Chen; Guo, Zi-Yuan; Abhijeet, Sambangi; Chen, Gong

Year: 2020

Venue: Nature communications

DOI: https://doi.org/10.1038/s41467-020-14855-3

Paper AAVvector-mediated in vivo reprogramming into pluripotency.

Senís, Elena; Mosteiro, Lluc; Wilkening, Stefan et al. · 2018 · Nature communications · DOI

Full title: AAVvector-mediated in vivo reprogramming into pluripotency.

Authors: Senís, Elena; Mosteiro, Lluc; Wilkening, Stefan; Wiedtke, Ellen; Nowrouzi, Ali; Afzal, Saira; Fronza, Raffaele; Landerer, Henrik; Abad, Maria; Niopek, Dominik; Schmidt, Manfred; Serrano, Manuel; Grimm, Dirk

Year: 2018

Venue: Nature communications

DOI: https://doi.org/10.1038/s41467-018-05059-x

Paper Self-attenuating adenovirus enables production of recombinant adeno-associated virus for high manufacturing yield without contamination

Su, Weiheng; Patrício, Maria I.; Duffy, Margaret R. et al. · 2022 · Nature Communications · DOI

Full title: Self-attenuating adenovirus enables production of recombinant adeno-associated virus for high manufacturing yield without contamination

Authors: Su, Weiheng; Patrício, Maria I.; Duffy, Margaret R.; Krakowiak, Jakub M.; Seymour, Leonard W.; Cawood, Ryan

Year: 2022

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-022-28738-2

Paper Adeno-associated virus capsid assembly is divergent and stochastic

Wörner, Tobias P.; Bennett, Antonette; Habka, Sana et al. · 2021 · Nature Communications · DOI

Full title: Adeno-associated virus capsid assembly is divergent and stochastic

Authors: Wörner, Tobias P.; Bennett, Antonette; Habka, Sana; Snijder, Joost; Friese, Olga; Powers, Thomas W.; Agbandje‐McKenna, Mavis; Heck, Albert J. R.

Year: 2021

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-021-21935-5

Paper The membrane associated accessory protein is an adeno-associated viral egress factor

Elmore, Zachary C.; Havlik, L. Patrick; Oh, Daniel K. et al. · 2021 · Nature Communications · DOI

Full title: The membrane associated accessory protein is an adeno-associated viral egress factor

Authors: Elmore, Zachary C.; Havlik, L. Patrick; Oh, Daniel K.; Anderson, Leif; Daaboul, George G.; Devlin, Garth; Vincent, Heather A.; Asokan, Aravind

Year: 2021

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-021-26485-4

Paper Engineering a synthetic gene circuit for high-performance inducible expression in mammalian systems

Carluccio, Giuliano De; Fusco, Virginia; Bernardo, Diego di · 2024 · Nature Communications · DOI

Full title: Engineering a synthetic gene circuit for high-performance inducible expression in mammalian systems

Authors: Carluccio, Giuliano De; Fusco, Virginia; Bernardo, Diego di

Year: 2024

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-024-47592-y

Paper Heterogeneity in an adeno-associated virus transfection-based production process limits the production efficiency.

Ladd, Brian; Tunmats, Sofia; Gräslund, Torbjörn et al. · 2025 · Scientific reports · DOI

Full title: Heterogeneity in an adeno-associated virus transfection-based production process limits the production efficiency.

Authors: Ladd, Brian; Tunmats, Sofia; Gräslund, Torbjörn; Daramola, Olalekan; Rockberg, Johan; Chotteau, Véronique

Year: 2025

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-025-26261-0

Paper LentiPro26: novel stable cell lines for constitutive lentiviral vector production

Tomás, Hélio A.; Rodrigues, Ana F.; Carrondo, Manuel J.T. et al. · 2018 · Scientific Reports · DOI

Full title: LentiPro26: novel stable cell lines for constitutive lentiviral vector production

Authors: Tomás, Hélio A.; Rodrigues, Ana F.; Carrondo, Manuel J.T.; Coroadinha, Ana S.

Year: 2018

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-018-23593-y

Paper Polyethylenimine based magnetic nanoparticles mediated non-viral CRISPR/Cas9 system for genome editing

Rohiwal, Sonali S.; Dvořáková, Nikola; Klı́ma, Jiřı́ et al. · 2020 · Scientific Reports · DOI

Full title: Polyethylenimine based magnetic nanoparticles mediated non-viral CRISPR/Cas9 system for genome editing

Authors: Rohiwal, Sonali S.; Dvořáková, Nikola; Klı́ma, Jiřı́; Vaškovičová, Michaela; Šenigl, Filip; Šlouf, Miroslav; Pavlová, Ewa; Štěpánek, Petr; Babuka, David; Beneš, Hynek; Ellederová, Zdeňka; Stieger, Knut

Year: 2020

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-020-61465-6

Paper CRISPR/Cas9 as an antiviral against Orthopoxviruses using an AAV vector.

Siegrist, Cathryn M; Kinahan, Sean M; Settecerri, Taylor et al. · 2020 · Scientific reports · DOI

Full title: CRISPR/Cas9 as an antiviral against Orthopoxviruses using an AAV vector.

Authors: Siegrist, Cathryn M; Kinahan, Sean M; Settecerri, Taylor; Greene, Adrienne C; Santarpia, Joshua L

Year: 2020

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-020-76449-9

Paper Engineered CHO cells as a novel AAV production platform for gene therapy delivery

Nagy, Abdou; Chakrabarti, Lina; Kurasawa, James et al. · 2023 · Scientific Reports · DOI

Full title: Engineered CHO cells as a novel AAV production platform for gene therapy delivery

Authors: Nagy, Abdou; Chakrabarti, Lina; Kurasawa, James; Mulagapati, Sri Hari Raju; Devine, Paul N.; Therres, Jamy; Chen, Yuyan; Schmelzer, Albert E.

Year: 2023

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-023-46298-3

Paper Production of adeno-associated virus vectors for in vitro and in vivo applications

Kimura, Toyokazu; Ferrán, Beatriz; Tsukahara, Yuko et al. · 2019 · Scientific Reports · DOI

Full title: Production of adeno-associated virus vectors for in vitro and in vivo applications

Authors: Kimura, Toyokazu; Ferrán, Beatriz; Tsukahara, Yuko; Shang, Qifan; Desai, Suveer; Fedoce, Alessandra; Pimentel, David R.; Luptak, Ivan; Adachi, Takeshi; Ido, Yasuo; Matsui, Reiko; Bachschmid, Markus

Year: 2019

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-019-49624-w

Paper Receptor-targeted liposome-peptide-siRNA nanoparticles represent an efficient delivery system for MRTF silencing in conjunctival fibrosis

Yu‐Wai‐Man, Cynthia; Tagalakis, Aristides D.; Manunta, Maria et al. · 2016 · Scientific Reports · DOI

Full title: Receptor-targeted liposome-peptide-siRNA nanoparticles represent an efficient delivery system for MRTF silencing in conjunctival fibrosis

Authors: Yu‐Wai‐Man, Cynthia; Tagalakis, Aristides D.; Manunta, Maria; Hart, Stephen L.; Khaw, Peng T.

Year: 2016

Venue: Scientific Reports

DOI: https://doi.org/10.1038/srep21881

Paper Efficacy and Safety of rAAV2-ND4 Treatment for Leber's Hereditary Optic Neuropathy.

Wan, Xing; Pei, Han; Zhao, Min-jian et al. · 2016 · Scientific reports · DOI

Full title: Efficacy and Safety of rAAV2-ND4 Treatment for Leber's Hereditary Optic Neuropathy.

Authors: Wan, Xing; Pei, Han; Zhao, Min-jian; Yang, Shuo; Hu, Wei-kun; He, Heng; Ma, Si-qi; Zhang, Ge; Dong, Xiao-yan; Chen, Chen; Wang, Dao-wen; Li, Bin

Year: 2016

Venue: Scientific reports

DOI: https://doi.org/10.1038/srep21587

Paper AAV Gene Therapy for MPS1-associated Corneal Blindness.

Vance, Melisa; Llanga, Telmo; Bennett, Will et al. · 2016 · Scientific reports · DOI

Full title: AAV Gene Therapy for MPS1-associated Corneal Blindness.

Authors: Vance, Melisa; Llanga, Telmo; Bennett, Will; Woodard, Kenton; Murlidharan, Giridhar; Chungfat, Neil; Asokan, Aravind; Gilger, Brian; Kurtzberg, Joanne; Samulski, R Jude; Hirsch, Matthew L

Year: 2016

Venue: Scientific reports

DOI: https://doi.org/10.1038/srep22131

Paper High-purity AAV vector production utilizing recombination-dependent minicircle formation and genetic coupling.

Liu, Hao; Liu, Nan; Zhou, Chen et al. · 2025 · EMBO molecular medicine · DOI

Full title: High-purity AAV vector production utilizing recombination-dependent minicircle formation and genetic coupling.

Authors: Liu, Hao; Liu, Nan; Zhou, Chen; Du, Ailing; Kapadia, Mayank; Tai, Phillip W L; Barton, Erik; Gao, Guangping; Wang, Dan

Year: 2025

Venue: EMBO molecular medicine

DOI: https://doi.org/10.1038/s44321-025-00248-w

Paper Intranasal gene therapy to prevent infection by SARS-CoV-2 variants

Sims, Joshua J.; Greig, Jenny A.; Michalson, Kristofer T. et al. · 2021 · PLoS Pathogens · DOI

Full title: Intranasal gene therapy to prevent infection by SARS-CoV-2 variants

Authors: Sims, Joshua J.; Greig, Jenny A.; Michalson, Kristofer T.; Lian, Sharon; Martino, Recchia; Meggersee, Rosemary; Turner, Kevin B.; Nambiar, Kalyani; Dyer, Cecilia; Hinderer, Christian; Horiuchi, Makoto; Yan, Hanying; Huang, Xin; Chen, Shu‐Jen; Wilson, James M.

Year: 2021

Venue: PLoS Pathogens

DOI: https://doi.org/10.1371/journal.ppat.1009544

Paper Adeno-associated virus capsid assembly is divergent and stochastic

Wörner, Tobias P.; Bennett, Antonette; Habka, Sana et al. · 2021 · Nature Communications · DOI

Full title: Adeno-associated virus capsid assembly is divergent and stochastic

Authors: Wörner, Tobias P.; Bennett, Antonette; Habka, Sana; Snijder, Joost; Friese, Olga; Powers, Thomas W.; Agbandje‐McKenna, Mavis; Heck, Albert J. R.

Year: 2021

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-021-21935-5

Paper Fast, efficient and virus-free generation of TRAC -replaced CAR T cells

Kath, Jonas; Du, Weijie; Thommandru, Bernice et al. · 2021 · DOI

Full title: Fast, efficient and virus-free generation of TRAC -replaced CAR T cells

Authors: Kath, Jonas; Du, Weijie; Thommandru, Bernice; Turk, Rolf; Amini, Leila; Stein, Maik; Zittel, Tatiana; Martini, Stefania; Ostendorf, Lennard; Wilhelm, Andreas; Akyüz, Levent; Rehm, Armin; Höpken, Uta E.; Prüß, Axel; Künkele, Annette; Jacobi, Ashley M.; Volk, Hans‐Dieter; Schmueck‐Henneresse, Michael; Reinke, Petra; Wagner, Dimitrios L.

Year: 2021

DOI: https://doi.org/10.1101/2021.02.14.431017

Paper The membrane associated accessory protein is an adeno-associated viral egress factor

Elmore, Zachary C.; Havlik, L. Patrick; Oh, Daniel K. et al. · 2021 · Nature Communications · DOI

Full title: The membrane associated accessory protein is an adeno-associated viral egress factor

Authors: Elmore, Zachary C.; Havlik, L. Patrick; Oh, Daniel K.; Anderson, Leif; Daaboul, George G.; Devlin, Garth; Vincent, Heather A.; Asokan, Aravind

Year: 2021

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-021-26485-4

Paper Transgene Expression in Cultured Cells Using Unpurified Recombinant Adeno-Associated Viral Vectors

Benyamini, Brian; Esbin, Meagan N.; Whitney, Oscar N. et al. · 2023 · DOI

Full title: Transgene Expression in Cultured Cells Using Unpurified Recombinant Adeno-Associated Viral Vectors

Authors: Benyamini, Brian; Esbin, Meagan N.; Whitney, Oscar N.; Walther, Nike; Maurer, Anna C.

Year: 2023

DOI: https://doi.org/10.1101/2023.03.20.533580

Paper Evolving Membrane-Associated Accessory Protein Variants for Improved Adeno-associated Virus Production

Schieferecke, Adam J.; Lee, Hyun‐Cheol; Chen, Aleysha T. et al. · 2023 · DOI

Full title: Evolving Membrane-Associated Accessory Protein Variants for Improved Adeno-associated Virus Production

Authors: Schieferecke, Adam J.; Lee, Hyun‐Cheol; Chen, Aleysha T.; Kilaru, Vindhya; Williams, Justin Krish; Schaffer, David V.

Year: 2023

DOI: https://doi.org/10.1101/2023.07.18.549400

Paper The CASwitch: a synthetic biology solution for high-performance inducible gene expression systems in biotechnology

Carluccio, Giuliano De; Fusco, Virginia; Bernardo, Diego di · 2023 · DOI

Full title: The CASwitch: a synthetic biology solution for high-performance inducible gene expression systems in biotechnology

Authors: Carluccio, Giuliano De; Fusco, Virginia; Bernardo, Diego di

Year: 2023

DOI: https://doi.org/10.1101/2023.09.20.558637

Paper Engineered retrovirus-like nanocarriers for messenger RNA delivery into neurons

Gu, Wenchao; Luozhong, Sijin; Cai, Simian et al. · 2022 · DOI

Full title: Engineered retrovirus-like nanocarriers for messenger RNA delivery into neurons

Authors: Gu, Wenchao; Luozhong, Sijin; Cai, Simian; Londhe, Ketaki; Elkasri, Nadine; Hawkins, Robert D.; Yuan, Zhefan; Su-Greene, Kai; Cruz, Mache; Chang, Yu‐Wei; McMullen, Patrick; Wu, Chunyan; Seo, Changwoo; Guru, Akash; Gao, Wenting; Sarmiento, Tara; Schaffer, Chris B.; Nishimura, Nozomi; Cerione, Richard A.; Warden, Melissa R.; Langer, Robert; Jiang, Shaoyi

Year: 2022

DOI: https://doi.org/10.1101/2022.12.07.518870

Paper Rational design of a compact CRISPR-Cas9 activator for AAV-mediated delivery

Vora, Suhani; Cheng, Jenny; Xiao, Ru et al. · 2018 · DOI

Full title: Rational design of a compact CRISPR-Cas9 activator for AAV-mediated delivery

Authors: Vora, Suhani; Cheng, Jenny; Xiao, Ru; VanDusen, Nathan J.; Quintino, Luís; Pu, William T.; Vandenberghe, Luk H.; Chavez, Alejandro; Church, George M.

Year: 2018

DOI: https://doi.org/10.1101/298620

Paper Two-Step Small Scale Purification of Recombinant Adeno-Associated Viruses

Chen, Shih‐Heng; Papaneri, Amy B.; Walker, Mitzie et al. · 2019 · PLOS ONE · DOI

Full title: Two-Step Small Scale Purification of Recombinant Adeno-Associated Viruses

Authors: Chen, Shih‐Heng; Papaneri, Amy B.; Walker, Mitzie; Scappini, Erica; Keys, Robert D.; Martin, Negin P.

Year: 2019

Venue: PLOS ONE

DOI: https://doi.org/10.1101/715029

Paper A comparison of synthetic oligodeoxynucleotides, DNA fragments and AAV-1 for targeted episomal and chromosomal gene repair

Leclerc, X.; Danos, Olivier; Scherman, Daniel et al. · 2009 · BMC Biotechnology · DOI

Full title: A comparison of synthetic oligodeoxynucleotides, DNA fragments and AAV-1 for targeted episomal and chromosomal gene repair

Authors: Leclerc, X.; Danos, Olivier; Scherman, Daniel; Kichler, Antoine

Year: 2009

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-9-35

Paper Profiling the impact of the promoters on CRISPR-Cas12a system in human cells

Li, Jinhe; Liang, Qinchun; Zhou, Huaping et al. · 2023 · Cellular & Molecular Biology Letters · DOI

Full title: Profiling the impact of the promoters on CRISPR-Cas12a system in human cells

Authors: Li, Jinhe; Liang, Qinchun; Zhou, Huaping; Zhou, Ming; Huang, Hongxin

Year: 2023

Venue: Cellular & Molecular Biology Letters

DOI: https://doi.org/10.1186/s11658-023-00454-9

Paper Viral vector production in the integrity® iCELLis® single-use fixed-bed bioreactor, from bench-scale to industrial scale

Lennaertz, Alexandre; Knowles, Shane; Drugmand, Jean‐Christophe et al. · 2013 · BMC Proceedings · DOI

Full title: Viral vector production in the integrity® iCELLis® single-use fixed-bed bioreactor, from bench-scale to industrial scale

Authors: Lennaertz, Alexandre; Knowles, Shane; Drugmand, Jean‐Christophe; Castillo, José

Year: 2013

Venue: BMC Proceedings

DOI: https://doi.org/10.1186/1753-6561-7-s6-p59

Paper Capsid protein expression and adeno-associated virus like particles assembly in Saccharomyces cerevisiae.

Backovic, Ana; Cervelli, Tiziana; Salvetti, Alessandra et al. · 2012 · Microbial cell factories · DOI

Full title: Capsid protein expression and adeno-associated virus like particles assembly in Saccharomyces cerevisiae.

Authors: Backovic, Ana; Cervelli, Tiziana; Salvetti, Alessandra; Zentilin, Lorena; Giacca, Mauro; Galli, Alvaro

Year: 2012

Venue: Microbial cell factories

DOI: https://doi.org/10.1186/1475-2859-11-124

Paper Analysis of the impact of pluronic acid on the thermal stability and infectivity of AAV6.2FF.

Thomas, Sylvia P; Spinelli, Marcus M; Rghei, Amira D et al. · 2024 · BMC biotechnology · DOI

Full title: Analysis of the impact of pluronic acid on the thermal stability and infectivity of AAV6.2FF.

Authors: Thomas, Sylvia P; Spinelli, Marcus M; Rghei, Amira D; Lopes, Jordyn A; Zielinska, Nicole; McLeod, Benjamin M; Pei, Yanlong; Zhang, Wei; Thebaud, Bernard; Karimi, Khalil; Wootton, Sarah K

Year: 2024

Venue: BMC biotechnology

DOI: https://doi.org/10.1186/s12896-024-00853-6

Paper Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer's disease neuropathology.

Chen, Fading; Swartzlander, Dan B; Ghosh, Anamitra et al. · 2021 · Molecular neurodegeneration · DOI

Full title: Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer's disease neuropathology.

Authors: Chen, Fading; Swartzlander, Dan B; Ghosh, Anamitra; Fryer, John D; Wang, Baiping; Zheng, Hui

Year: 2021

Venue: Molecular neurodegeneration

DOI: https://doi.org/10.1186/s13024-021-00426-7

Paper Advanced biomanufacturing and evaluation of adeno-associated virus

Chen, Kai; Kim, Seulhee; Yang, Siying et al. · 2024 · Journal of Biological Engineering · DOI

Full title: Advanced biomanufacturing and evaluation of adeno-associated virus

Authors: Chen, Kai; Kim, Seulhee; Yang, Siying; Varadkar, Tanvi; Zhou, Zhuoxin “Zora”; Zhang, Jiashuai; Zhou, Lufang; Liu, Margaret

Year: 2024

Venue: Journal of Biological Engineering

DOI: https://doi.org/10.1186/s13036-024-00409-4

Paper Development of a perfusion process for serum-free adenovirus vector herpes zoster vaccine production

Sun, Yang; Huang, Lingling; Nie, Jianqi et al. · 2022 · AMB Express · DOI

Full title: Development of a perfusion process for serum-free adenovirus vector herpes zoster vaccine production

Authors: Sun, Yang; Huang, Lingling; Nie, Jianqi; Feng, Kai; Liu, Yupeng; Bai, Zhonghu

Year: 2022

Venue: AMB Express

DOI: https://doi.org/10.1186/s13568-022-01398-7

Paper Utilizing minimally purified secreted rAAV for rapid and cost-effective manipulation of gene expression in the CNS.

Goodwin, Marshall S; Croft, Cara L; Futch, Hunter S et al. · 2020 · Molecular neurodegeneration · DOI

Full title: Utilizing minimally purified secreted rAAV for rapid and cost-effective manipulation of gene expression in the CNS.

Authors: Goodwin, Marshall S; Croft, Cara L; Futch, Hunter S; Ryu, Daniel; Ceballos-Diaz, Carolina; Liu, Xuefei; Paterno, Giavanna; Mejia, Catalina; Deng, Doris; Menezes, Kimberly; Londono, Laura; Arjona, Kefren; Parianos, Mary; Truong, Van; Rostonics, Eva; Hernandez, Amanda; Boye, Sanford L; Boye, Shannon E; Levites, Yona; Cruz, Pedro E; Golde, Todd E

Year: 2020

Venue: Molecular neurodegeneration

DOI: https://doi.org/10.1186/s13024-020-00361-z

Paper Molecular barcoding of viral vectors enables mapping and optimization of mRNA trans -splicing

Davidsson, Marcus; Díaz-Fernández, Paula; Torroba, Marcos et al. · 2018 · RNA · DOI

Full title: Molecular barcoding of viral vectors enables mapping and optimization of mRNA trans -splicing

Authors: Davidsson, Marcus; Díaz-Fernández, Paula; Torroba, Marcos; Schwich, Oliver Daniel; Aldrin-Kirk, Patrick; Quintino, Luís; Heuer, Andreas; Wang, Gang; Lundberg, Cecilia; Björklund, Tomas

Year: 2018

Venue: RNA

DOI: https://doi.org/10.1261/rna.063925.117

Paper Adeno-Associated Viruses Serotype 2-Mediated RNA Interference Efficiently Inhibits Rabies Virus Replication In Vitro and In Vivo

Wu, Hongxia; Wang, Hualei; Guo, Xiaofeng et al. · 2013 · Journal of Veterinary Medical Science · DOI

Full title: Adeno-Associated Viruses Serotype 2-Mediated RNA Interference Efficiently Inhibits Rabies Virus Replication In Vitro and In Vivo

Authors: Wu, Hongxia; Wang, Hualei; Guo, Xiaofeng; Yang, Yujiao; Ma, Jinzhu; Wang, Tiecheng; Gao, Yuwei; Zhao, Yongkun; Yang, Songtao; Xia, Xianzhu

Year: 2013

Venue: Journal of Veterinary Medical Science

DOI: https://doi.org/10.1292/jvms.13-0127

Paper Synergistic Effect of Cationic Lipids with Different Polarheads, Central Core Structures and Hydrophobic Tails on Gene Transfection Efficiency

Niyomtham, Nattisa; Apiratikul, Nuttapon; Chanchang, Kanyarat et al. · 2014 · Biological and Pharmaceutical Bulletin · DOI

Full title: Synergistic Effect of Cationic Lipids with Different Polarheads, Central Core Structures and Hydrophobic Tails on Gene Transfection Efficiency

Authors: Niyomtham, Nattisa; Apiratikul, Nuttapon; Chanchang, Kanyarat; Opanasopit, Praneet; Yingyongnarongkul, Boon‐ek

Year: 2014

Venue: Biological and Pharmaceutical Bulletin

DOI: https://doi.org/10.1248/bpb.b14-00349

Paper Potent immunogenicity and neutralization of recombinant adeno-associated virus expressing the glycoprotein of severe fever with thrombocytopenia virus.

Shimoyama, Toshiaki; Oba, Mami; Takemae, Hitoshi et al. · 2024 · The Journal of veterinary medical science · DOI

Full title: Potent immunogenicity and neutralization of recombinant adeno-associated virus expressing the glycoprotein of severe fever with thrombocytopenia virus.

Authors: Shimoyama, Toshiaki; Oba, Mami; Takemae, Hitoshi; Omatsu, Tsutomu; Tani, Hideki; Mizutani, Tetsuya

Year: 2024

Venue: The Journal of veterinary medical science

DOI: https://doi.org/10.1292/jvms.23-0375

Paper Production of Adeno-Associated Virus Vector Serotype rh.10 and Optimization of Its Purification via Chloroform Extraction.

Tamura, Naoki; Suzuki, Kanzo; Shiraki, Hirono et al. · 2025 · Biological & pharmaceutical bulletin · DOI

Full title: Production of Adeno-Associated Virus Vector Serotype rh.10 and Optimization of Its Purification via Chloroform Extraction.

Authors: Tamura, Naoki; Suzuki, Kanzo; Shiraki, Hirono; Waguri, Issei; Segi-Nishida, Eri

Year: 2025

Venue: Biological & pharmaceutical bulletin

DOI: https://doi.org/10.1248/bpb.b24-00850

Paper Eukaryotic-driven directed evolution of Cas9 nucleases

Ruta, Giulia Vittoria; Ciciani, Matteo; Kheir, Eyemen et al. · 2024 · Genome biology · DOI

Full title: Eukaryotic-driven directed evolution of Cas9 nucleases

Authors: Ruta, Giulia Vittoria; Ciciani, Matteo; Kheir, Eyemen; Gentile, Michele Domenico; Amistadi, Simone; Casini, Antonio; Cereseto, Anna

Year: 2024

Venue: Genome biology

DOI: https://doi.org/10.1186/s13059-024-03215-9

Paper Recombinant AAV Vectors for Enhanced Expression of Authentic IgG.

Fuchs, Sebastian P; Martinez-Navio, José M; Gao, Guangping et al. · 2016 · PloS one · DOI

Full title: Recombinant AAV Vectors for Enhanced Expression of Authentic IgG.

Authors: Fuchs, Sebastian P; Martinez-Navio, José M; Gao, Guangping; Desrosiers, Ronald C

Year: 2016

Venue: PloS one

DOI: https://doi.org/10.1371/journal.pone.0158009

Paper A single dose recombinant AAV based CHIKV vaccine elicits robust and durable protective antibody responses in mice.

Zhu, Qin-Xuan; Zhang, Ya-Nan; Zhang, Hong-Qing et al. · 2024 · PLoS neglected tropical diseases · DOI

Full title: A single dose recombinant AAV based CHIKV vaccine elicits robust and durable protective antibody responses in mice.

Authors: Zhu, Qin-Xuan; Zhang, Ya-Nan; Zhang, Hong-Qing; Leng, Chao; Deng, Cheng-Lin; Wang, Xin; Li, Jia-Jia; Ye, Xiang-Li; Zhang, Bo; Li, Xiao-Dan

Year: 2024

Venue: PLoS neglected tropical diseases

DOI: https://doi.org/10.1371/journal.pntd.0012604

Paper Untitled

Ornek, Dogan, Sayed, Nida, Sousa, Matthew, Crue, Connor, Chari, Ravi, Delzell, Stephanie, Cardoso, Adalia, Lin, Roy, Ramsey, Philip, Erler, A, Mas, N De, Ramsey, P, Henderson, G, Ramsey, P, Lemkus, T, Ramsey, P, Gotwalt, C, Weese, M, Gotwalt, C, Xu, L, Hong, Y, Meeker, W, Zhao, H, Lee, K, Daris, M, Lin, Y, Wolfe, T, Sheng, J, Plewa, C, Wang, S, Meisen, W, Moo, P, Xu, X, Silva, C, Kamen, A, Guan, J, Chen, K, Si, Y, Kim, Zhou, Z, Kim, S, Zhou, L, Liu, X, Kontogiannis, T, Braybrook, J, Mcelroy, C, Foy, C, Whale, A, Quaglia, M, Smales, C, Grieger, J, Soltys, S, Samulski, R, Fu, Q, Lee, Y, Green, E, Wang, Y, Park, S, Polanco, A, Lee, K, Betenbaugh, M, Mcnally, D, Yoon, S, Philip, J · 2025 · BioProcessing Journal · DOI

Full title: Untitled

Authors: Ornek, Dogan, Sayed, Nida, Sousa, Matthew, Crue, Connor, Chari, Ravi, Delzell, Stephanie, Cardoso, Adalia, Lin, Roy, Ramsey, Philip, Erler, A, Mas, N De, Ramsey, P, Henderson, G, Ramsey, P, Lemkus, T, Ramsey, P, Gotwalt, C, Weese, M, Gotwalt, C, Xu, L, Hong, Y, Meeker, W, Zhao, H, Lee, K, Daris, M, Lin, Y, Wolfe, T, Sheng, J, Plewa, C, Wang, S, Meisen, W, Moo, P, Xu, X, Silva, C, Kamen, A, Guan, J, Chen, K, Si, Y, Kim, Zhou, Z, Kim, S, Zhou, L, Liu, X, Kontogiannis, T, Braybrook, J, Mcelroy, C, Foy, C, Whale, A, Quaglia, M, Smales, C, Grieger, J, Soltys, S, Samulski, R, Fu, Q, Lee, Y, Green, E, Wang, Y, Park, S, Polanco, A, Lee, K, Betenbaugh, M, Mcnally, D, Yoon, S, Philip, J

Year: 2025

Venue: BioProcessing Journal

DOI: https://doi.org/10.12665/j24oa-ornek

Paper Enhanced Transgene Expression from Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell Lines In Vitro and in Murine Hepatocytes In Vivo

Chen, Ling; Wang, Yuan; Yuan, Lu et al. · 2020 · UNC Libraries · DOI

Full title: Enhanced Transgene Expression from Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell Lines In Vitro and in Murine Hepatocytes In Vivo

Authors: Chen, Ling; Wang, Yuan; Yuan, Lu; Wang, Lina; Jayandharan, Giridhara R.; Aslanidi, George; Li, Baozheng; Cheng, Binbin; Ma, Wenqin; Lentz, Thomas; Ling, Changquan; Xiao, Xiao; Samulski, R. Jude; Muzyczka, Nicholas; Srivastava, Arun

Year: 2020

Venue: UNC Libraries

DOI: https://doi.org/10.17615/7w6y-pk12

Paper Production of Lentiviral Vectors Encoding Recombinant Factor VIII Expression in Serum-Free Suspension Cultures

Caron, Angelo Luis; Picanço‐Castro, Virgínia; Ansorge, Sven et al. · 2015 · Brazilian Archives of Biology and Technology · DOI

Full title: Production of Lentiviral Vectors Encoding Recombinant Factor VIII Expression in Serum-Free Suspension Cultures

Authors: Caron, Angelo Luis; Picanço‐Castro, Virgínia; Ansorge, Sven; Covas, Dimas Tadeu; Kamen, Amine; Swiech, Kamilla

Year: 2015

Venue: Brazilian Archives of Biology and Technology

DOI: https://doi.org/10.1590/s1516-89132015060367

Paper Characterization of Extracellular Vesicles Secreted in Lentiviral Producing HEK293SF Cell Cultures

Minh, Aline Do; Star, Alexandra T.; Stupak, Jacek et al. · 2021 · Viruses · DOI

Full title: Characterization of Extracellular Vesicles Secreted in Lentiviral Producing HEK293SF Cell Cultures

Authors: Minh, Aline Do; Star, Alexandra T.; Stupak, Jacek; Fulton, Kelly M.; Haqqani, Arsalan S.; Gélinas, Jean‐François; Li, Jianjun; Twine, Susan M.; Kamen, Amine

Year: 2021

Venue: Viruses

DOI: https://doi.org/10.3390/v13050797

Paper A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis

Prakash, Satya; Shao, M.; Paul, Arghya et al. · 2012 · International Journal of Nanomedicine · DOI

Full title: A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis

Authors: Prakash, Satya; Shao, M.; Paul, Arghya; Abbasi, Sana; Chahal, Parminder S.; Mena, Jimmy A.; Montes, Johnny; Kamen, Amine

Year: 2012

Venue: International Journal of Nanomedicine

DOI: https://doi.org/10.2147/ijn.s26891

Paper An Overview of Methods and Tools for Transfection of Eukaryotic Cells in vitro

Fus-Kujawa, Agnieszka; Pruś, Paweł; Bajdak-Rusinek, Karolina et al. · 2021 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: An Overview of Methods and Tools for Transfection of Eukaryotic Cells in vitro

Authors: Fus-Kujawa, Agnieszka; Pruś, Paweł; Bajdak-Rusinek, Karolina; Teper, Paulina; Gawron, Katarzyna; Kowalczuk, Agnieszka; Sieroń, Aleksander L.

Year: 2021

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2021.701031

Paper AAV process intensification by perfusion bioreaction and integrated clarification

Mendes, João P.; Fernandes, Bárbara; Pineda, Earl et al. · 2022 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: AAV process intensification by perfusion bioreaction and integrated clarification

Authors: Mendes, João P.; Fernandes, Bárbara; Pineda, Earl; Kudugunti, Shashi; Bransby, Mike; Gantier, René; Peixoto, Cristina; Alves, Paula M.; Roldão, António; Silva, Ricardo J. S.

Year: 2022

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2022.1020174

Paper Targeted UDP-glucose ceramide glucosyltransferase stable overexpression induces a metabolic switch improving cell performance at high cell density.

Rahimi, Marzia; Nielsen, Lars K; Lavado-García, Jesús · 2025 · Frontiers in bioengineering and biotechnology · DOI

Full title: Targeted UDP-glucose ceramide glucosyltransferase stable overexpression induces a metabolic switch improving cell performance at high cell density.

Authors: Rahimi, Marzia; Nielsen, Lars K; Lavado-García, Jesús

Year: 2025

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2025.1690203

Paper Quantitative analysis of preferential utilization of AAV ITR as the packaging terminal signal.

Li, Xin; Miller, Lohra Mickelle; Chrzanowski, Matthew et al. · 2023 · Frontiers in bioengineering and biotechnology · DOI

Full title: Quantitative analysis of preferential utilization of AAV ITR as the packaging terminal signal.

Authors: Li, Xin; Miller, Lohra Mickelle; Chrzanowski, Matthew; Tian, Jiahe; Jarrold, Martin F; Herzog, Roland W; Xiao, Weidong; Draper, Benjamin; Zhang, Junping

Year: 2023

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2023.1327433

Paper AAV8 vector induced gliosis following neuronal transgene expression.

McLeod, Faye; McDermott, Elaine; Mak, Shermin et al. · 2024 · Frontiers in neuroscience · DOI

Full title: AAV8 vector induced gliosis following neuronal transgene expression.

Authors: McLeod, Faye; McDermott, Elaine; Mak, Shermin; Walsh, Darren; Turnbull, Mark; LeBeau, Fiona E N; Jackson, Andrew; Trevelyan, Andrew J; Clowry, Gavin J

Year: 2024

Venue: Frontiers in neuroscience

DOI: https://doi.org/10.3389/fnins.2024.1287228

Paper Platforms, advances, and technical challenges in virus-like particles-based vaccines

Gupta, Reeshu; Arora, Kajal; Roy, Sourav Singha et al. · 2023 · Frontiers in Immunology · DOI

Full title: Platforms, advances, and technical challenges in virus-like particles-based vaccines

Authors: Gupta, Reeshu; Arora, Kajal; Roy, Sourav Singha; Joseph, Abyson; Rastogi, Ruchir; Arora, Nupur Mehrotra; Kundu, Prabuddha K.

Year: 2023

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2023.1123805

Paper AAV9-mediated gene delivery to liver grafts during static cold storage in a rat liver transplant model.

Gao, Qimeng; Kesseli, Samuel J; Gonzalez, Trevor et al. · 2023 · Frontiers in transplantation · DOI

Full title: AAV9-mediated gene delivery to liver grafts during static cold storage in a rat liver transplant model.

Authors: Gao, Qimeng; Kesseli, Samuel J; Gonzalez, Trevor; Zhang, Min; Kahan, Riley; Krischak, Madison; Halpern, Samantha E; Song, Mingqing; Xu, Hongzhi; Abraham, Nader; Anwar, Imran J; Alderete, Isaac; Asokan, Aravind; Hartwig, Matthew G; Barbas, Andrew S

Year: 2023

Venue: Frontiers in transplantation

DOI: https://doi.org/10.3389/frtra.2023.1171272

Paper Directed evolution of AAV capsids for improved efficacy and specificity of delivery to preclinical models of human liver

Kwiatek, Magdalena; Michalski, Aleksander; Abramowicz, Karolina et al. · 2023 · Lekarz Wojskowy · DOI

Full title: Directed evolution of AAV capsids for improved efficacy and specificity of delivery to preclinical models of human liver

Authors: Kwiatek, Magdalena; Michalski, Aleksander; Abramowicz, Karolina; Rutyna, Paweł; Wasiak, Magdalena; Reichert, M.; Lisowski, Leszek

Year: 2023

Venue: Lekarz Wojskowy

DOI: https://doi.org/10.53301/lw/156374

Paper Construction of PR39 recombinant AAV under control of the HRE promoter and the effect of recombinant AAV on gene therapy of ischemic heart disease.

Sun, Lijun; Hao, Yuewen; Nie, Xiaowei et al. · 2012 · Experimental and therapeutic medicine · DOI

Full title: Construction of PR39 recombinant AAV under control of the HRE promoter and the effect of recombinant AAV on gene therapy of ischemic heart disease.

Authors: Sun, Lijun; Hao, Yuewen; Nie, Xiaowei; Zhang, Xuexin; Yang, Guangxiao; Wang, Quanying

Year: 2012

Venue: Experimental and therapeutic medicine

DOI: https://doi.org/10.3892/etm.2012.674

Paper Bioprocess Development and Bioreactor Scale-Up for the Production of Recombinant Lentiviral Viral Vectors in HEK293 Suspension Cell Culture

Robitaille, Julien; Manceur, Aziza; Rodenbrock, Anja et al. · 2024 · Biochemistry · DOI

Full title: Bioprocess Development and Bioreactor Scale-Up for the Production of Recombinant Lentiviral Viral Vectors in HEK293 Suspension Cell Culture

Authors: Robitaille, Julien; Manceur, Aziza; Rodenbrock, Anja; Loignon, Martin

Year: 2024

Venue: Biochemistry

DOI: https://doi.org/10.5772/intechopen.114000

Paper Peer Review #1 of "Transfection types, methods and strategies: a technical review (v0.3)"

Chong, Zhi Xiong; Keong, Swee; Yong, Wan et al. · 2021 · DOI

Full title: Peer Review #1 of "Transfection types, methods and strategies: a technical review (v0.3)"

Authors: Chong, Zhi Xiong; Keong, Swee; Yong, Wan; Corresp, Ho; Ho, Wan Yong; Ahmadzada, T; Reid, G; Mckenzie, D; Al-Dosari, M; Gao, X; Alabdullah, A; Al-Abdulaziz, B; Alsalem, H; Magrashi, A; Pulicat, S; Almzroua, A; Almohanna, F; Assiri, A; Tassan, N Al; Al-Mubarak, B; Aldred, S; Collins, P; Trinklein, N; Allison, S; Milner, J; Arnold, A; Laporte, V; Dumont, S; Appert-Collin, A; Erbacher, P; Coupin, G; Levy, R; Poindron, P; Gies, J; Ayub, S; Ling, F; Too, See; Cun, W; Balak, J; Graaf, N De; Zaldumbide, A; Rabelink, T; Hoeben, R; Koning, E De; Carlotti, F; Balazs, D; Godbey, W; Basiouni, S; Fuhrmann, H; Schumann, J; Bauler, M; Roberts, J; Wu, C.-C; Fan, B; Ferrara, F; Yip, B; Diao, S; Kim, Y.-I; Moore, J; Zhou, S; Wielgosz, M; Ryu, B; Throm, R; Bell, N; Micklefield, J; Borawski, J; Lindeman, A; Buxton, F; Labow, M; Gaither, L; Brunner, S; Sauer, T; Carotta, S; Cotten, M; Saltik, M; Wagner, E; Canoy, R; Andr, F; Shmakova, A; Wiels, J; Lipinski, M; Vassetzky, Y; Germini, D; Cao, E; Chen, Y; Cui, Z; Foster, P; Chan, J; Krichevsky, A; Kosik, K; Chen, X; Gu, S; Chen, B.-F; Shen, W.-L; Yin, Z; Xu, G.-W; Hu, J.-J; Zhu, T; Li, G; Wan, C

Year: 2021

DOI: https://doi.org/10.7287/peerj.11165v0.3/reviews/1

Paper Chitosan-DNA/siRNA Nanoparticles for Gene Therapy

Shi, Qin; Marcio, J.; Zhang, Xiaoling et al. · 2011 · InTech eBooks · DOI

Full title: Chitosan-DNA/siRNA Nanoparticles for Gene Therapy

Authors: Shi, Qin; Marcio, J.; Zhang, Xiaoling; Dai, Kerong; Benderdour, Mohamed; Polonio, Júlio César

Year: 2011

Venue: InTech eBooks

DOI: https://doi.org/10.5772/21903

Paper The Role of the Adeno-Associated Virus Capsid in Gene Transfer

Vliet, Kim Van; Blouin, Véronique; Brument, Nicole et al. · 2008 · Methods in molecular biology · DOI

Full title: The Role of the Adeno-Associated Virus Capsid in Gene Transfer

Authors: Vliet, Kim Van; Blouin, Véronique; Brument, Nicole; Agbandje‐McKenna, Mavis; Snyder, Richard O.

Year: 2008

Venue: Methods in molecular biology

DOI: https://doi.org/10.1007/978-1-59745-210-6_2

Paper Production of recombinant vesicular stomatitis virus-based vectors by tangential flow depth filtration

Göbel, Sven; Pelz, Lars; Silva, Cristina A. T. et al. · 2024 · Applied Microbiology and Biotechnology · DOI

Full title: Production of recombinant vesicular stomatitis virus-based vectors by tangential flow depth filtration

Authors: Göbel, Sven; Pelz, Lars; Silva, Cristina A. T.; Brühlmann, Béla; Hill, Charles E.; Altomonte, Jennifer; Kamen, Amine; Reichl, Udo; Genzel, Yvonne

Year: 2024

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-024-13078-6

Paper Proton-transfer-reaction mass spectrometry (PTR-MS) for online monitoring of glucose depletion and cell concentrations in HEK 293 gene therapy processes.

Bayer, Benjamin; Maccani, Andreas; Jahn, Johanna et al. · 2022 · Biotechnology letters · DOI

Full title: Proton-transfer-reaction mass spectrometry (PTR-MS) for online monitoring of glucose depletion and cell concentrations in HEK 293 gene therapy processes.

Authors: Bayer, Benjamin; Maccani, Andreas; Jahn, Johanna; Duerkop, Mark; Kapeller, Ewald; Pletzenauer, Robert; Kraus, Barbara; Striedner, Gerald; Hernandez Bort, Juan A

Year: 2022

Venue: Biotechnology letters

DOI: https://doi.org/10.1007/s10529-021-03205-y

Paper Enhanced ER protein processing gene expression increases rAAV yield and full capsid ratio in HEK293 cells.

Fu, Qiang; Wang, Yongdan; Qin, Jiansong et al. · 2024 · Applied microbiology and biotechnology · DOI

Full title: Enhanced ER protein processing gene expression increases rAAV yield and full capsid ratio in HEK293 cells.

Authors: Fu, Qiang; Wang, Yongdan; Qin, Jiansong; Xie, Dongming; McNally, David; Yoon, Seongkyu

Year: 2024

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-024-13281-5

Paper Molecular design for recombinant adeno-associated virus (rAAV) vector production

Aponte, Juan José; Barajas, Daniel; Peltier, Joseph et al. · 2017 · Applied Microbiology and Biotechnology · DOI

Full title: Molecular design for recombinant adeno-associated virus (rAAV) vector production

Authors: Aponte, Juan José; Barajas, Daniel; Peltier, Joseph; Bardliving, Cameron; Shamlou, P. Ayazi; Gold, Daniel

Year: 2017

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-017-8670-1

Paper Factors affecting rAAV titers during triple-plasmid transient transfection in HEK-293 cells.

Pistek, Martina; Andorfer, Peter; Grabherr, Reingard et al. · 2024 · Biotechnology letters · DOI

Full title: Factors affecting rAAV titers during triple-plasmid transient transfection in HEK-293 cells.

Authors: Pistek, Martina; Andorfer, Peter; Grabherr, Reingard; Kraus, Barbara; Hernandez Bort, Juan A

Year: 2024

Venue: Biotechnology letters

DOI: https://doi.org/10.1007/s10529-024-03520-0

Paper Targeted knockdown of ATM, ATR, and PDEδ increases Gag HIV-1 VLP production in HEK293 cells

Díaz‐Maneh, Andy; Pérez‐Rubio, Pol; Granés, Cristina Rigau et al. · 2025 · Applied Microbiology and Biotechnology · DOI

Full title: Targeted knockdown of ATM, ATR, and PDEδ increases Gag HIV-1 VLP production in HEK293 cells

Authors: Díaz‐Maneh, Andy; Pérez‐Rubio, Pol; Granés, Cristina Rigau; Bosch-Molist, Laia; Lavado‐García, Jesús; Gòdia, Francesc; Cervera, Laura

Year: 2025

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-024-13389-8

Paper Production of retroviral vectors in continuous high cell density culture

Hein, Marc D.; Kazenmaier, Daniel; Heuvel, Yasemin van et al. · 2023 · Applied Microbiology and Biotechnology · DOI

Full title: Production of retroviral vectors in continuous high cell density culture

Authors: Hein, Marc D.; Kazenmaier, Daniel; Heuvel, Yasemin van; Dogra, Tanya; Cattaneo, Maurizio; Kupke, Sascha Young; Stitz, Jörn; Genzel, Yvonne; Reichl, Udo

Year: 2023

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-023-12689-9

Paper Pharmaceutical Development of AAV-Based Gene Therapy Products for the Eye

Rodrigues, Gerard A.; Shalaev, Evgenyi; Karami, Thomas K. et al. · 2018 · Pharmaceutical Research · DOI

Full title: Pharmaceutical Development of AAV-Based Gene Therapy Products for the Eye

Authors: Rodrigues, Gerard A.; Shalaev, Evgenyi; Karami, Thomas K.; Cunningham, James M.; Slater, Nigel K.H.; Rivers, Hongwen M.

Year: 2018

Venue: Pharmaceutical Research

DOI: https://doi.org/10.1007/s11095-018-2554-7

Paper Comparative transcriptomic and proteomic kinetic analysis of adeno-associated virus production systems.

Lin, Yu-Chieh; Lu, Min; Cai, Wen et al. · 2024 · Applied microbiology and biotechnology · DOI

Full title: Comparative transcriptomic and proteomic kinetic analysis of adeno-associated virus production systems.

Authors: Lin, Yu-Chieh; Lu, Min; Cai, Wen; Hu, Wei-Shou

Year: 2024

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-024-13203-5

Paper Adenoviral vectors for cardiovascular gene therapy applications: a clinical and industry perspective

Schwartze, Julian Tristan; Havenga, Menzo; Bakker, Wilfried A.M. et al. · 2022 · Journal of Molecular Medicine · DOI

Full title: Adenoviral vectors for cardiovascular gene therapy applications: a clinical and industry perspective

Authors: Schwartze, Julian Tristan; Havenga, Menzo; Bakker, Wilfried A.M.; Bradshaw, Angela C.; Nicklin, Stuart A.

Year: 2022

Venue: Journal of Molecular Medicine

DOI: https://doi.org/10.1007/s00109-022-02208-0

Paper Enhancer viruses and a transgenic platform for combinatorial cell subclass-specific labeling

Graybuck, Lucas T.; Daigle, Tanya L.; Sedeño-Cortés, Adriana E. et al. · 2019 · DOI

Full title: Enhancer viruses and a transgenic platform for combinatorial cell subclass-specific labeling

Authors: Graybuck, Lucas T.; Daigle, Tanya L.; Sedeño-Cortés, Adriana E.; Walker, Miranda; Kalmbach, Brian; Lenz, Garreck; Nguyen, Thuc Nghi; Garren, Emma; Kim, Tae Kyung; Siverts, La’Akea; Bendrick, Jacqueline L.; Zhou, Thomas; Mortrud, Marty; Yao, Shenqin; Çetin, Ali; Larsen, Rachael; Esposito, Luke; Gore, Bryan B.; Szelenyi, Eric R; Morin, Elyse L.; Mich, John K.; Dee, Nick; Goldy, Jeff; Smith, Kimberly A.; Yao, Zizhen; Gradinaru, Viviana; Sunkin, Susan M.; Lein, Ed S.; Levi, Boaz P.; Ting, Jonathan T.; Zeng, Hongkui; Tasic, Bosiljka

Year: 2019

DOI: https://doi.org/10.1101/525014

Paper Targeted overexpression of relaxin receptor 1 (RXFP1) with chronic administration of relaxin as a novel inotropic approach for heart failure treatment

Sasipong, Nuttarak · 2020 · heiDOK (Heidelberg University) · DOI

Full title: Targeted overexpression of relaxin receptor 1 (RXFP1) with chronic administration of relaxin as a novel inotropic approach for heart failure treatment

Authors: Sasipong, Nuttarak

Year: 2020

Venue: heiDOK (Heidelberg University)

DOI: https://doi.org/10.11588/heidok.00027301

Paper Abstracts from the 25th European Society for Animal Cell Technology Meeting: Cell Technologies for Innovative Therapies

Andréa, Mc Cann,; Grégory, Mathy,; Laetitia, Malphettes, · 2018 · BMC Proceedings · DOI

Full title: Abstracts from the 25th European Society for Animal Cell Technology Meeting: Cell Technologies for Innovative Therapies

Authors: Andréa, Mc Cann,; Grégory, Mathy,; Laetitia, Malphettes,

Year: 2018

Venue: BMC Proceedings

DOI: https://doi.org/10.1186/s12919-018-0097-x

Paper With small viruses come giant responsibilities - Next-generation parvoviral vectors for human gene therapy with extended packaging capacity and enhanced safety profile

Fakhiri, Julia · 2019 · heiDOK (Heidelberg University) · DOI

Full title: With small viruses come giant responsibilities - Next-generation parvoviral vectors for human gene therapy with extended packaging capacity and enhanced safety profile

Authors: Fakhiri, Julia

Year: 2019

Venue: heiDOK (Heidelberg University)

DOI: https://doi.org/10.11588/heidok.00027326

Paper Non-viral Gene Delivery Methods for Bone and Joints

Gantenbein, Benjamin; Tang, Shirley; Guerrero, Julien et al. · 2020 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Non-viral Gene Delivery Methods for Bone and Joints

Authors: Gantenbein, Benjamin; Tang, Shirley; Guerrero, Julien; Higuita‐Castro, Natalia; Salazar‐Puerta, Ana I.; Croft, Andreas S.; Gazdhar, Amiq; Purmessur, Devina

Year: 2020

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2020.598466

Paper Nano-vesicles for gene delivery

Tan, Karen Li Ping · 2006 · DOI

Full title: Nano-vesicles for gene delivery

Authors: Tan, Karen Li Ping

Year: 2006

DOI: https://doi.org/10.32657/10356/2194

Paper Development of AAV-mediated gene therapy for autosomal recessive bestrophinopathy

Wood, Shaun · 2017 · DOI

Full title: Development of AAV-mediated gene therapy for autosomal recessive bestrophinopathy

Authors: Wood, Shaun

Year: 2017

DOI: https://doi.org/10.5287/ora-1475jodo5

Paper Development of a CENH3-based and non-viral vector system

Fueloep, Stefanie · 2014 · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · DOI

Full title: Development of a CENH3-based and non-viral vector system

Authors: Fueloep, Stefanie

Year: 2014

Venue: Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München)

DOI: https://doi.org/10.5282/edoc.16537

Paper Culture media selection and feeding strategy for high titer production of a lentiviral vector by stable producer clones cultivated at high cell density

Shen, Chun Fang; Tremblay, Sonia; Sabourin-Poirier, Catherine et al. · 2022 · Bioprocess and Biosystems Engineering · DOI

Full title: Culture media selection and feeding strategy for high titer production of a lentiviral vector by stable producer clones cultivated at high cell density

Authors: Shen, Chun Fang; Tremblay, Sonia; Sabourin-Poirier, Catherine; Burney, Elodie; Broussau, Sophie; Manceur, Aziza; Rodenbrock, Anja; Voyer, Robert; Loignon, Martin; Ansorge, Sven; Gilbert, Rénald

Year: 2022

Venue: Bioprocess and Biosystems Engineering

DOI: https://doi.org/10.1007/s00449-022-02737-5

Paper Improving HEK293-based AAV-production using GSMMs, and a multi-omics approach

L. Zehetner; D. Széliová; B. Kraus et al. · 2024 · bioRxiv · DOI

Full title: Improving HEK293-based AAV-production using GSMMs, and a multi-omics approach

Authors: L. Zehetner; D. Széliová; B. Kraus; J. A. H. Bort; J. Zanghellini; Team; Manfred Ostermann; Katharina Portner; Ronald Leitner; Sonja Muellner; Robert Pachlinger; Susanne Heider; Carolin-Isabel Kahlig; Lucia Micutkova; Peter Andorfer; Bernd Eisenhut; Felix Innthaler; Fuchsberger; Fabian Knofl; Andrea Seybel; Sabine Unterthurner

Year: 2024

Venue: bioRxiv

DOI: https://doi.org/10.1101/2024.10.10.617556

Paper Rapid establishment of a HEK 293 cell line expressing FVIII-BDD using AAV site-specific integration plasmids.

Liu, Xiaomei; Ping, Han; Zhang, Chun · 2014 · BMC research notes · DOI

Full title: Rapid establishment of a HEK 293 cell line expressing FVIII-BDD using AAV site-specific integration plasmids.

Authors: Liu, Xiaomei; Ping, Han; Zhang, Chun

Year: 2014

Venue: BMC research notes

DOI: https://doi.org/10.1186/1756-0500-7-626

Thesis Enhanced efficiency of lactosylated poly-L-lysine-mediated gene transfer into cystic fibrosis airway epithelial cells

Vliegenthart, J.F.G.; Knollen, W.J.W.; Schembri, F.M. et al. · 1999 · Utrecht University · DOI

Full title: Enhanced efficiency of lactosylated poly-L-lysine-mediated gene transfer into cystic fibrosis airway epithelial cells

Authors: Vliegenthart, J.F.G.; Knollen, W.J.W.; Schembri, F.M.; Gerwig, G.J.; Glick, M.C.; Scanlin, T.F.

Year: 1999

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/5327

Thesis Impact of Formulation Conditions on Lipid Nanoparticle Characteristics and Functional Delivery of CRISPR RNP for Gene Knock-Out and Correction

Walther, Johanna; Wilbie, Danny; Tissingh, Vincent S.J. et al. · 2022 · Utrecht University · DOI

Full title: Impact of Formulation Conditions on Lipid Nanoparticle Characteristics and Functional Delivery of CRISPR RNP for Gene Knock-Out and Correction

Authors: Walther, Johanna; Wilbie, Danny; Tissingh, Vincent S.J.; Öktem, Mert; Van Der Veen, Heleen; Lou, Bo; Mastrobattista, Enrico

Year: 2022

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/422276

Thesis Adeno-associated virus capsid assembly is divergent and stochastic

Wörner, Tobias P; Bennett, Antonette; Habka, Sana et al. · 2021 · Utrecht University · DOI

Full title: Adeno-associated virus capsid assembly is divergent and stochastic

Authors: Wörner, Tobias P; Bennett, Antonette; Habka, Sana; Snijder, Joost; Friese, Olga; Powers, Thomas; Agbandje-McKenna, Mavis; Heck, Albert J R

Year: 2021

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/411860

Thesis Lipid nanoparticle-mediated messenger RNA delivery for ex vivo engineering of natural killer cells

Douka, Stefania; Brandenburg, Lisa E; Casadidio, Cristina et al. · 2023 · Utrecht University · DOI

Full title: Lipid nanoparticle-mediated messenger RNA delivery for ex vivo engineering of natural killer cells

Authors: Douka, Stefania; Brandenburg, Lisa E; Casadidio, Cristina; Walther, Johanna; Garcia, Bianca Bonetto Moreno; Spanholtz, Jan; Raimo, Monica; Hennink, Wim E; Mastrobattista, Enrico; Caiazzo, Massimiliano

Year: 2023

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/432851

Thesis Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses

Fakhiri, Julia; Schneider, Marc A.; Puschhof, Jens et al. · 2019 · Utrecht University · DOI

Full title: Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses

Authors: Fakhiri, Julia; Schneider, Marc A.; Puschhof, Jens; Stanifer, Megan; Schildgen, Verena; Holderbach, Stefan; Voss, Yannik; El Andari, Jihad; Schildgen, Oliver; Boulant, Steeve; Meister, Michael; Clevers, Hans; Yan, Ziying; Qiu, Jianming; Grimm, Dirk

Year: 2019

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/439383

Thesis Production of AAV vectors for gene therapy : a cost-effectiveness and risk assessment

Rodríguez Pinhao Miessner, Diego · 2016 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Production of AAV vectors for gene therapy : a cost-effectiveness and risk assessment

Authors: Rodríguez Pinhao Miessner, Diego

Year: 2016

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/104215

Thesis Use of Transient Transfection for cGMP Manufacturing of eOD-GT8 60mer, a Self-Assembling Nanoparticle Germline-Targeting HIV-1 Vaccine Candidate

Sharma, Vaneet K.; Menis, Sergey; Brower, Evan T. et al. · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Use of Transient Transfection for cGMP Manufacturing of eOD-GT8 60mer, a Self-Assembling Nanoparticle Germline-Targeting HIV-1 Vaccine Candidate

Authors: Sharma, Vaneet K.; Menis, Sergey; Brower, Evan T.; Sayeed, Eddy; Ackland, Jim; Lombardo, Angela; Cottrell, Christopher A.; Torres, Jonathan L.; Hassell, Thomas; Ward, Andrew B.; Tsvetnitsky, Vadim; Schief, William R.

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/155438

Thesis Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse

Kauffman, Kevin John; Oberli, Matthias; Dorkin, Joseph Robert et al. · 2019 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse

Authors: Kauffman, Kevin John; Oberli, Matthias; Dorkin, Joseph Robert; Hurtado, Juan E.; Kaczmarek, James Cliff; Bhadani, Shivani; Wyckoff, Jeffrey; Langer, Robert S; Jaklenec, Ana; Anderson, Daniel Griffith

Year: 2019

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/122015

Thesis In vitro and ex vivo strategies for intracellular delivery

Sahay, Gaurav; Stewart, Martin P; Sharei, Armon Reza et al. · 2017 · Massachusetts Institute of Technology (MIT) · DOI

Full title: In vitro and ex vivo strategies for intracellular delivery

Authors: Sahay, Gaurav; Stewart, Martin P; Sharei, Armon Reza; Ding, Xiaoyun Sean; Langer, Robert S; Jensen, Klavs F

Year: 2017

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/110923

Thesis Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells

Nguyen, Tam N.T.; Sha, Sha; Hong, Moo Sun et al. · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells

Authors: Nguyen, Tam N.T.; Sha, Sha; Hong, Moo Sun; Maloney, Andrew J.; Barone, Paul W.; Neufeld, Caleb; Wolfrum, Jacqueline; Springs, Stacy L.; Sinskey, Anthony J.; Braatz, Richard D.

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/135559.2

Thesis Producing and Concentrating Lenti-Cre for Mouse Infections

Gierut, J. J.; Haigis, K. M.; Jacks, Tyler E. · 2018 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Producing and Concentrating Lenti-Cre for Mouse Infections

Authors: Gierut, J. J.; Haigis, K. M.; Jacks, Tyler E.

Year: 2018

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/116575

Thesis Multidose transient transfection of human embryonic kidney 293 cells modulates recombinant adeno‐associated virus2/5 Rep protein expression and influences the enrichment fraction of filled capsids

Srinivasan, Prasanna; Canova, Christopher T; Sha, Sha et al. · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Multidose transient transfection of human embryonic kidney 293 cells modulates recombinant adeno‐associated virus2/5 Rep protein expression and influences the enrichment fraction of filled capsids

Authors: Srinivasan, Prasanna; Canova, Christopher T; Sha, Sha; Nguyen, Tam NT; Joseph, John; Sangerman, Jose; Maloney, Andrew J; Katsikis, Georgios; Ou, Rui Wen; Hong, Moo Sun; Ng, Jaclyn; Yuan, Arella; Antov, Daniel; Song, Sally; Chen, Wenyu; Neufeld, Caleb; Wolfrum, Jacqueline M; Barone, Paul W; Sinskey, Anthony J; Springs, Stacy L; Braatz, Richard D

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/157695

Thesis Enhancing Production of Recombinant Proteins from Mammalian Cells

Wong, Victor V.T.; Wong, Niki S.C.; Tan, Hong-Kiat et al. · 2003 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Enhancing Production of Recombinant Proteins from Mammalian Cells

Authors: Wong, Victor V.T.; Wong, Niki S.C.; Tan, Hong-Kiat; Wang, Daniel I.C.; Yap, Miranda G.S.

Year: 2003

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/3782

Thesis Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel et al. · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Authors: Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel; Dang, Brendan; Wolffe, Lenna A; Atari, Adel; Tseng, Yuen-Yi; Love, J Christopher

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/163220

Thesis Development of a Lentiviral Vector for High-Yield Production of Synthetic and Recombinant GCase for Gaucher Disease Therapy

Coelho, Ana Carolina; Wiezel, Claudia Emília Vieira; de Campos, Alline Cristina et al. · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Development of a Lentiviral Vector for High-Yield Production of Synthetic and Recombinant GCase for Gaucher Disease Therapy

Authors: Coelho, Ana Carolina; Wiezel, Claudia Emília Vieira; de Campos, Alline Cristina; Figueiredo, Lílian Louise Souza; Suardi, Gabriela Aparecida Marcondes; de Paula Bernardes, Juliana; da Cunha Tirapelli, Daniela Pretti; Faça, Vitor Marcel; Abraham, Kuruvilla Joseph; Carlotti-Júnior, Carlos Gilberto; Siciliano, Velia; Weiss, Ron; Gerson, Stanton; Fontes, Aparecida Maria

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/162371

Thesis Perfusion‐Based Production of rAAV via an Intensified Transient Transfection Process

Nguyen, Tam NT; Park, Damdae; Canova, Christopher T et al. · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Perfusion‐Based Production of rAAV via an Intensified Transient Transfection Process

Authors: Nguyen, Tam NT; Park, Damdae; Canova, Christopher T; Sangerman, Jose; Srinivasan, Prasanna; Ou, Rui Wen; Barone, Paul W; Neufeld, Caleb; Wolfrum, Jacqueline M; Springs, Stacy L; Sinskey, Anthony J; Braatz, Richard D

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/162858

Thesis Weighing the DNA Content of Adeno-Associated Virus Vectors with Zeptogram Precision Using Nanomechanical Resonators

Katsikis, Georgios; Hwang, Iris E; Wang, Wade et al. · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Weighing the DNA Content of Adeno-Associated Virus Vectors with Zeptogram Precision Using Nanomechanical Resonators

Authors: Katsikis, Georgios; Hwang, Iris E; Wang, Wade; Bhat, Vikas S; McIntosh, Nicole L; Karim, Omair A; Blus, Bartlomiej J; Sha, Sha; Agache, Vincent; Wolfrum, Jacqueline M; Springs, Stacy L; Sinskey, Anthony J; Barone, Paul W; Braatz, Richard D; Manalis, Scott R

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/146983

Thesis A comparison of intravenous and indirect intracoronary delivery of AAV5, AAV6 and AAV9 for cardiac gene transfer in mice

Fang, Hongfei · 2011 · University of California, San Diego (UCSD) · DOI

Full title: A comparison of intravenous and indirect intracoronary delivery of AAV5, AAV6 and AAV9 for cardiac gene transfer in mice

Authors: Fang, Hongfei

Year: 2011

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/1024d4fh

Thesis Development of a Novel Dual AAV System for Therapeutic Delivery of BDNF

Cheng, Yuhsiang · 2018 · University of California, San Diego (UCSD) · DOI

Full title: Development of a Novel Dual AAV System for Therapeutic Delivery of BDNF

Authors: Cheng, Yuhsiang

Year: 2018

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/3v16w70m

Thesis Analysis of the Effects of RAS-MAPK Pathway Modulatory Adeno-associated Viral Vectors

Volz, Avery · 2024 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Analysis of the Effects of RAS-MAPK Pathway Modulatory Adeno-associated Viral Vectors

Authors: Volz, Avery

Year: 2024

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1721145531361946

Thesis Adeno-associated virus (AAV) transduction of primary human CD4+T lymphocytes

Kamel, Sahar Hussein · 2014 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Adeno-associated virus (AAV) transduction of primary human CD4+T lymphocytes

Authors: Kamel, Sahar Hussein

Year: 2014

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=wright1409957026

Thesis Optimalizace rekombinantní exprese proteinů v HEK293 buněčné linii

Bláha, Jan · 2017 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Optimalizace rekombinantní exprese proteinů v HEK293 buněčné linii

Authors: Bláha, Jan

Year: 2017

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/29866

Thesis Generation of recombinant Chinese hamster ovary cell lines by microinjection

Derouazi, M.; Flaction, R.; Girard, P. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Generation of recombinant Chinese hamster ovary cell lines by microinjection

Authors: Derouazi, M.; Flaction, R.; Girard, P.; de Jesus, M.; Jordan, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7686

Thesis Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Blessing, Daniel; Vachey, Gabriel; Pythoud, Catherine et al. · 2019 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Authors: Blessing, Daniel; Vachey, Gabriel; Pythoud, Catherine; Rey, Maria; Padrun, Vivianne; Wurm, Florian M.; Schneider, Bernard L.; Deglon, Nicole

Year: 2019

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/158621

Thesis Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation

Jordan, M.; Schallhorn, A.; Wurm, F. M. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation

Authors: Jordan, M.; Schallhorn, A.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7661

Thesis Transient transfection induces different intracellular calcium signaling in CHO K1 versus HEK 293 cells

Preuss, A. K.; Connor, J. A.; Vogel, H. · 2019 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transient transfection induces different intracellular calcium signaling in CHO K1 versus HEK 293 cells

Authors: Preuss, A. K.; Connor, J. A.; Vogel, H.

Year: 2019

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/160503

Thesis High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells

Hildinger, Markus; Baldi, Lucia; Stettler, Matthieu et al. · 2019 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells

Authors: Hildinger, Markus; Baldi, Lucia; Stettler, Matthieu; Wurm, Florian M.

Year: 2019

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/160357

Thesis Recombinant protein production by large-scale transient gene expression in mammalian cells : state of the art and future perspectives

Baldi, L; Hacker, DL; Adam, M et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Recombinant protein production by large-scale transient gene expression in mammalian cells : state of the art and future perspectives

Authors: Baldi, L; Hacker, DL; Adam, M; Wurm, FM

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/8764

Thesis Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Lee, John; Nist-Lund, Carl; Solanes, Paola et al. · 2020 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Authors: Lee, John; Nist-Lund, Carl; Solanes, Paola; Goldberg, Hannah; Wu, Jason; Pan, Bifeng; Schneider, Bernard L.; Holt, Jeffrey R.

Year: 2020

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/171017

Thesis Magnetofection Potentiates Gene Delivery to Cultured Endothelial Cells

Krötz, Florian; Sohn, Hae-Young; Gloe, Torsten et al. · 2003 · Technical University of Munich (TUM) · DOI

Full title: Magnetofection Potentiates Gene Delivery to Cultured Endothelial Cells

Authors: Krötz, Florian;Sohn, Hae-Young;Gloe, Torsten;Plank, Christian;Pohl, Ulrich

Year: 2003

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1218851

Thesis Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand

Chua, Gek Kee · 2011 · Massey University · DOI

Full title: Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand

Authors: Chua, Gek Kee

Year: 2011

Venue: Massey University

DOI: http://hdl.handle.net/10179/2832

Thesis Vergleich dreier Vektorsysteme für den koronaren Gentransfer

Sack, Philipp Andreas · 2010 · Technical University of Munich · DOI

Full title: Vergleich dreier Vektorsysteme für den koronaren Gentransfer

Authors: Sack, Philipp Andreas

Year: 2010

Venue: Technical University of Munich

DOI: https://mediatum.ub.tum.de/602308

Thesis Alternative Produktion rekombinanter Adeno-assoziierter Viren für die Gentherapie

Kuhrs, Annette · 2006 · Freie Universität Berlin (Refubium) · DOI

Full title: Alternative Produktion rekombinanter Adeno-assoziierter Viren für die Gentherapie

Authors: Kuhrs, Annette

Year: 2006

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/12369

Thesis Semliki Forest Virus as a Vector: Pros and Cons for Its Use in Biopharmaceuticals Production

Fernández Núñez, Eutimio Gustavo [UNESP]; Calil Jorge, Soraia Attie; Astray, Renato Mancini et al. · 2014 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Semliki Forest Virus as a Vector: Pros and Cons for Its Use in Biopharmaceuticals Production

Authors: Fernández Núñez, Eutimio Gustavo [UNESP]; Calil Jorge, Soraia Attie; Astray, Renato Mancini; Rezende, Alexandre Goncalves de; Vale da Costa, Bruno Labate; Ventini Monteiro, Daniella Cristina; Pereira, Carlos Augusto; Tonso, Aldo

Year: 2014

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1590/S1516-89132013000500018

Thesis Transient transfection of serum-free suspension HEK 293 cell culture for efficient production of human rFVIII

Covas, Dimas Tadeu · 2011 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Transient transfection of serum-free suspension HEK 293 cell culture for efficient production of human rFVIII

Authors: Covas, Dimas Tadeu

Year: 2011

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.1186/1472-6750-11-114

Thesis Quantitative correlation between transcriptional levels of ER chaperone, peroximal protein and FVIII productivity in human Hek-293 cell line

Covas, Dimas Tadeu · 2013 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Quantitative correlation between transcriptional levels of ER chaperone, peroximal protein and FVIII productivity in human Hek-293 cell line

Authors: Covas, Dimas Tadeu

Year: 2013

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.1186/2193-1801-2-328

Thesis Utilização de shRNA anti-hexon, anti-IVa2 e anti-pol durante a produção de vírus adeno-associado como estratégia de eliminar Adenovírus helper:: prova de princípio

Strauss, Bryan Eric · 2016 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Utilização de shRNA anti-hexon, anti-IVa2 e anti-pol durante a produção de vírus adeno-associado como estratégia de eliminar Adenovírus helper:: prova de princípio

Authors: Strauss, Bryan Eric

Year: 2016

Venue: Universidade de São Paulo – USP Digital Library

DOI: http://www.teses.usp.br/teses/disponiveis/5/5155/tde-13032017-101533/

Thesis Efficiency of transgene expression in bovine cells varies according to cell type and gene transfer method

Dias, Angelo José Burla · 2019 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Efficiency of transgene expression in bovine cells varies according to cell type and gene transfer method

Authors: Dias, Angelo José Burla

Year: 2019

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.17533/udea.rccp.v32n1a04

Thesis Serum-free suspension adaptation of HEK-293T cells: basis for large-scale biopharmaceutical production

Mizukami, Amanda · 2021 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Serum-free suspension adaptation of HEK-293T cells: basis for large-scale biopharmaceutical production

Authors: Mizukami, Amanda

Year: 2021

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.1590/1678-4324-2021200817

Thesis A synthetic approach to produce recombinant adeno-associated virus (rAAV) in Chinese hamster ovary (CHO) cells

Cai, Wen · 2024 · University of Minnesota - Digital Conservancy · DOI

Full title: A synthetic approach to produce recombinant adeno-associated virus (rAAV) in Chinese hamster ovary (CHO) cells

Authors: Cai, Wen

Year: 2024

Venue: University of Minnesota - Digital Conservancy

DOI: https://hdl.handle.net/11299/259525

Thesis Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency

Sork, Helena; Nordin, Joel Z; Turunen, Janne J et al. · 2016 · Utrecht University · DOI

Full title: Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency

Authors: Sork, Helena; Nordin, Joel Z; Turunen, Janne J; Wiklander, Oscar Pb; Bestas, Burcu; Zaghloul, Eman M; Margus, Helerin; Padari, Kärt; Duru, Adil D; Corso, Giulia; Bost, Jeremy; Vader, Pieter; Pooga, Margus; Smith, Ci Edvard; Wood, Matthew Ja; Schiffelers, Raymond M; Hällbrink, Mattias; Andaloussi, Samir El

Year: 2016

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/336850

Thesis Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

Muller, N.; Derouazi, M.; Van Tilborgh, F. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

Authors: Muller, N.; Derouazi, M.; Van Tilborgh, F.; Wulhfard, S.; Hacker, D. L.; Jordan, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9754

Thesis Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions

Backliwal, G; Hildinger, M; Chenuet, S et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions

Authors: Backliwal, G; Hildinger, M; Chenuet, S; Wulhfard, S; De Jesus, M; Wurm, FM

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41410

Thesis Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

Zhang, Xiaowei; Garcia, Isabel Fernandez; Baldi, Lucia et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

Authors: Zhang, Xiaowei; Garcia, Isabel Fernandez; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/52051

Thesis Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76323

Thesis The kinetics of polyethylenimine-mediated transfection in suspension cultures of Chinese hamster ovary cells

Bertschinger, Martin; Schertenleib, Arnaud; Cevey, Jean et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: The kinetics of polyethylenimine-mediated transfection in suspension cultures of Chinese hamster ovary cells

Authors: Bertschinger, Martin; Schertenleib, Arnaud; Cevey, Jean; Hacker, David L.; Wurm, Florian M.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/58359

Thesis Study of the improved Sf9 transient gene expression process

Shen, Xiao; Hacker, David L.; Baldi, Lucia et al. · 2014 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Study of the improved Sf9 transient gene expression process

Authors: Shen, Xiao; Hacker, David L.; Baldi, Lucia; Wurm, Florian M.

Year: 2014

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/100125

Thesis A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing

Woodruff, Kristina; Maerkl, Sebastian J. · 2016 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing

Authors: Woodruff, Kristina; Maerkl, Sebastian J.

Year: 2016

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/127380

Thesis RECOMBINANT AAV6 GENE THERAPY VECTORS: PROCESS OPTIMIZATION AND SCALE UP INTO THE iCELLis NANO BIOREACTOR

Borges, Gwynneth · 2021 · Johns Hopkins University · DOI

Full title: RECOMBINANT AAV6 GENE THERAPY VECTORS: PROCESS OPTIMIZATION AND SCALE UP INTO THE iCELLis NANO BIOREACTOR

Authors: Borges, Gwynneth

Year: 2021

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/63567

Thesis Comparison of CRISPR/Cas Endonucleases for in vivo Retinal Gene Editing

Li, F; Wing, K; Wang, JH et al. · 2020 · University of Melbourne · DOI

Full title: Comparison of CRISPR/Cas Endonucleases for in vivo Retinal Gene Editing

Authors: Li, F; Wing, K; Wang, JH; Luu, CD; Bender, JA; Chen, J; Wang, Q; Lu, Q; Nguyen Tran, MT; Young, KM; Wong, RCB; Pébay, A; Cook, AL; Hung, SSC; Liu, GS; Hewitt, AW

Year: 2020

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/251585

Thesis The effect of cell penetrating peptides on transfection activity and cytotoxicity of polyallylamine

Sabouri-Rad, S; Oskuee, RK; Mahmoodi, A et al. · 2021 · University of Melbourne · DOI

Full title: The effect of cell penetrating peptides on transfection activity and cytotoxicity of polyallylamine

Authors: Sabouri-Rad, S; Oskuee, RK; Mahmoodi, A; Gholami, L; Malaekeh-Nikouei, B

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/277463

Thesis Development of an efficient, non-viral transfection method for studying gene function and bone growth in human primary cranial suture mesenchymal cells reveals that the cells respond to BMP2 and BMP3

Dwivedi, PP; Anderson, PJ; Powell, BC · 2022 · University of Melbourne · DOI

Full title: Development of an efficient, non-viral transfection method for studying gene function and bone growth in human primary cranial suture mesenchymal cells reveals that the cells respond to BMP2 and BMP3

Authors: Dwivedi, PP; Anderson, PJ; Powell, BC

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/304511

Thesis Transduktion av plasmid-komplex genom cellmembran med hjälp av akustofluidisk infångning

Eriksson, John · 2024 · Lund University Student Papers · DOI

Full title: Transduktion av plasmid-komplex genom cellmembran med hjälp av akustofluidisk infångning

Authors: Eriksson, John

Year: 2024

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9162786

Thesis Generation of stable suspension producer cell lines for serum-free lentivirus production

Klimpel, M; Terrao, M; Bräuer, M et al. · 2024 · University of Melbourne · DOI

Full title: Generation of stable suspension producer cell lines for serum-free lentivirus production

Authors: Klimpel, M; Terrao, M; Bräuer, M; Dersch, H; Biserni, M; Melo Do Nascimento, L; Schwingal, S; Vogel, JE; Ferlemann, C; Brandt, T; Lal, NI; Bridgeman, K; Petzke, A; McDwyer, E; Lim, JL; Oh, S; Brumatti, G; Garcia Minambres, A; Otte, E; Noll, T; Pirzas, V; Laux, H

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/351064

Thesis AAV capsid bioengineering in primary human retina models

Westhaus, A; Eamegdool, SS; Fernando, M et al. · 2024 · University of Melbourne · DOI

Full title: AAV capsid bioengineering in primary human retina models

Authors: Westhaus, A; Eamegdool, SS; Fernando, M; Fuller-Carter, P; Brunet, AA; Miller, AL; Rashwan, R; Knight, M; Daniszewski, M; Lidgerwood, GE; Pébay, A; Hewitt, A; Santilli, G; Thrasher, AJ; Carvalho, LS; Gonzalez-Cordero, A; Jamieson, RV; Lisowski, L

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/344430

Thesis Development of an Improved Transient Triple Transfection System with Focus on Engineering the Helper Plasmid for Enhanced rAAV Production

Pohle, Thilo · 2023 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Development of an Improved Transient Triple Transfection System with Focus on Engineering the Helper Plasmid for Enhanced rAAV Production

Authors: Pohle, Thilo

Year: 2023

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/35606/1/PhDThesis_THP_final.pdf

Thesis Improving AAV Retinal Gene Therapy for Batten Disease

Schwartz, Maura Katherine · 2022 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Improving AAV Retinal Gene Therapy for Batten Disease

Authors: Schwartz, Maura Katherine

Year: 2022

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1669911156168454

Thesis Characterisation of cellular responses and gene delivery capabilities within porous agarose scaffolds

Sullivan, Matthew Scott · 2024 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Characterisation of cellular responses and gene delivery capabilities within porous agarose scaffolds

Authors: Sullivan, Matthew Scott

Year: 2024

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/35132/1/M%20S%20Sullivan%202024.pdf

Thesis Non-viral gene delivery with pH-sensitive gemini nanoparticles : synthesis of gemini surfactant building blocks, characterization and in vitro screening of transfection efficiency and toxicity

Donkuru, McDonald · 2009 · University of Saskatchewan - HARVEST · DOI

Full title: Non-viral gene delivery with pH-sensitive gemini nanoparticles : synthesis of gemini surfactant building blocks, characterization and in vitro screening of transfection efficiency and toxicity

Authors: Donkuru, McDonald

Year: 2009

Venue: University of Saskatchewan - HARVEST

DOI: http://hdl.handle.net/10388/etd-01132009-131423

Thesis Optimalizace kultivačního média HEK293 buněčné linie

Čuperková, Romana · 2017 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Optimalizace kultivačního média HEK293 buněčné linie

Authors: Čuperková, Romana

Year: 2017

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/45606

Thesis Genome engineering in vivo for modeling of human diseases enhanced by AVV technology

Nickl, Petr · 2025 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Genome engineering in vivo for modeling of human diseases enhanced by AVV technology

Authors: Nickl, Petr

Year: 2025

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/196257

Thesis Možné přístupy k terapii cystické fibrosy

Král, Jan · 2019 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Možné přístupy k terapii cystické fibrosy

Authors: Král, Jan

Year: 2019

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/97888

Thesis Vývoj techniky pro transfer genů do T-lymfocytů pomocí polyomavirových struktur a peptidu LAH4

Schreiberová, Lucie · 2020 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Vývoj techniky pro transfer genů do T-lymfocytů pomocí polyomavirových struktur a peptidu LAH4

Authors: Schreiberová, Lucie

Year: 2020

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/122022

Thesis Optimalizace expresního systému HEK293 buněčné linie pomocí regulace buněčného cyklu a apoptózy

Poláchová, Edita · 2017 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Optimalizace expresního systému HEK293 buněčné linie pomocí regulace buněčného cyklu a apoptózy

Authors: Poláchová, Edita

Year: 2017

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/68567

Thesis Study of transposon-mediated cell pool and cell line generation in CHO cells

Balasubramanian, Sowmya · 2015 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Study of transposon-mediated cell pool and cell line generation in CHO cells

Authors: Balasubramanian, Sowmya

Year: 2015

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/113896

Thesis Establishment of recombinant mammalian cell lines : new approaches

Derouazi, Madiha · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Establishment of recombinant mammalian cell lines : new approaches

Authors: Derouazi, Madiha

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/212504

Thesis Correlation between cell cycle and calcium phosphate transient transfection of CHO cells

Grosjean, Frédéric · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Correlation between cell cycle and calcium phosphate transient transfection of CHO cells

Authors: Grosjean, Frédéric

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/211990

Thesis Transient gene expression for rapid protein production : studies & optimizations under serum-free conditions

Muller, Natalie · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transient gene expression for rapid protein production : studies & optimizations under serum-free conditions

Authors: Muller, Natalie

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/214287

Thesis CELL ENGINEERING AND CULTURE MEDIA MODIFICATION STUDIES TO IMPROVE THE CELL CULTURE PERFORMANCE

Dhara, Venkata Gayatri · 2019 · Johns Hopkins University · DOI

Full title: CELL ENGINEERING AND CULTURE MEDIA MODIFICATION STUDIES TO IMPROVE THE CELL CULTURE PERFORMANCE

Authors: Dhara, Venkata Gayatri

Year: 2019

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/60428

Thesis Expressão gênica empregando pseudopartículas em células de mamíferos (HEK 293T e Huh 7.0) cultivadas em diferentes meios de cultura livres de soro

Jorge, Soraia Attie Calil · 2016 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Expressão gênica empregando pseudopartículas em células de mamíferos (HEK 293T e Huh 7.0) cultivadas em diferentes meios de cultura livres de soro

Authors: Jorge, Soraia Attie Calil

Year: 2016

Venue: Universidade de São Paulo – USP Digital Library

DOI: http://www.teses.usp.br/teses/disponiveis/87/87131/tde-24082016-113658/

Thesis Optimisation and Application of Nanoelectroporation for Clonal β-Cell Transfection

Ekstrand, Frida · 2025 · Lund University (LUP) · DOI

Full title: Optimisation and Application of Nanoelectroporation for Clonal β-Cell Transfection

Authors: Ekstrand, Frida

Year: 2025

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/097ab391-be95-4cc3-b370-b1ea33b8a03d

Thesis Identifizierung und Optimierung kritischer Schritte bei der Transfektion eukaryontischer Zellen

Schurig, Michael · 2009 · Technical University of Munich · DOI

Full title: Identifizierung und Optimierung kritischer Schritte bei der Transfektion eukaryontischer Zellen

Authors: Schurig, Michael

Year: 2009

Venue: Technical University of Munich

DOI: https://mediatum.ub.tum.de/667447

Thesis Optmierung des Gentransfers in humane Keratinozyten mittels rekombinanter Adeno-assoziierter Virus Vektoren

Eisenried, Angelika · 2007 · Technical University of Munich · DOI

Full title: Optmierung des Gentransfers in humane Keratinozyten mittels rekombinanter Adeno-assoziierter Virus Vektoren

Authors: Eisenried, Angelika

Year: 2007

Venue: Technical University of Munich

DOI: https://mediatum.ub.tum.de/620611

Thesis Molecular characterization of the avian adeno-associated virus and its use for the development of a viral vector system

Estevez, Carlos · 2024 · University of Georgia - UGA Open Scholar · DOI

Full title: Molecular characterization of the avian adeno-associated virus and its use for the development of a viral vector system

Authors: Estevez, Carlos

Year: 2024

Venue: University of Georgia - UGA Open Scholar

DOI: https://openscholar.uga.edu/record/9951/files/estevez_carlos_n_200405_phd.pdf

Thesis Gene modification and biotechnological applications of mesenchymal stem cells

Bosch, Pablo · 2024 · University of Georgia - UGA Open Scholar · DOI

Full title: Gene modification and biotechnological applications of mesenchymal stem cells

Authors: Bosch, Pablo

Year: 2024

Venue: University of Georgia - UGA Open Scholar

DOI: https://openscholar.uga.edu/record/20238/files/bosch_pablo_200508_phd.pdf

Thesis The design, development and characterization of a self-replicating DNA expression technology

de Moor, Warren Ralph Josephus · 2022 · University of Cape Town · DOI

Full title: The design, development and characterization of a self-replicating DNA expression technology

Authors: de Moor, Warren Ralph Josephus

Year: 2022

Venue: University of Cape Town

DOI: http://hdl.handle.net/11427/36847

Thesis Untersuchungen zum Gentransfer in die Lunge mittels nicht-viraler Pulveraerosole und viraler Vektoren basierend auf dem Adeno-assoziierten Virus (AAV) 2/9

Pfeifer, Corinna · 2011 · Freie Universität Berlin (Refubium) · DOI

Full title: Untersuchungen zum Gentransfer in die Lunge mittels nicht-viraler Pulveraerosole und viraler Vektoren basierend auf dem Adeno-assoziierten Virus (AAV) 2/9

Authors: Pfeifer, Corinna

Year: 2011

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/6992

Thesis Evaluierung von Nukleoprotein-kodierenden AAV Vektoren als breitenwirksame Influenza-Impfstoffe

Fiddeke, Katharina · 2017 · Freie Universität Berlin (Refubium) · DOI

Full title: Evaluierung von Nukleoprotein-kodierenden AAV Vektoren als breitenwirksame Influenza-Impfstoffe

Authors: Fiddeke, Katharina

Year: 2017

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/8958

Thesis Herstellung optimierter Sf9-Zelllinien für die Baculovirus-basierte Produktion rekombinanter AAV5-Vektoren mit hoher Infektiosität

Casteleyn, Vincent · 2022 · Freie Universität Berlin (Refubium) · DOI

Full title: Herstellung optimierter Sf9-Zelllinien für die Baculovirus-basierte Produktion rekombinanter AAV5-Vektoren mit hoher Infektiosität

Authors: Casteleyn, Vincent

Year: 2022

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/33543

Thesis Adeno-Associated Virus Vectors for Gene Therapy

Mietzsch, Mario · 2014 · Freie Universität Berlin (Refubium) · DOI

Full title: Adeno-Associated Virus Vectors for Gene Therapy

Authors: Mietzsch, Mario

Year: 2014

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/6047

Thesis Advances in crustacean cell culture

Claydon, Kerry · 2009 · James Cook University · DOI

Full title: Advances in crustacean cell culture

Authors: Claydon, Kerry

Year: 2009

Venue: James Cook University

DOI: https://researchonline.jcu.edu.au/11946/11/JCU_11946_Claydon_2009_thesis.pdf

Thesis Correcting CPS1 Deficiency in Primary Human Hepatocytes In Vivo Using AAV Delivered Cell-Cycle Independent Targeted Genome Editing

Christina, Sharntie · 2024 · University of Sydney · DOI

Full title: Correcting CPS1 Deficiency in Primary Human Hepatocytes In Vivo Using AAV Delivered Cell-Cycle Independent Targeted Genome Editing

Authors: Christina, Sharntie

Year: 2024

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/32857

Thesis Improving the immunogenicity of recombinant adeno-associated virus

Ussher, James Edgeworth · 2010 · University of Auckland · DOI

Full title: Improving the immunogenicity of recombinant adeno-associated virus

Authors: Ussher, James Edgeworth

Year: 2010

Venue: University of Auckland

DOI: https://hdl.handle.net/2292/6030

Thesis Adeno-Associated Virus Gene Therapy For Maple Syrup Urine Disease

Mullany, Kathryn Louise · 2025 · University of Sydney · DOI

Full title: Adeno-Associated Virus Gene Therapy For Maple Syrup Urine Disease

Authors: Mullany, Kathryn Louise

Year: 2025

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/34263

Thesis Endogenous UMIs as quantifiable reporter elements – validation studies & applications in rAAV vectorology

Wilmott, Patrick Gurney · 2023 · University of Sydney · DOI

Full title: Endogenous UMIs as quantifiable reporter elements – validation studies & applications in rAAV vectorology

Authors: Wilmott, Patrick Gurney

Year: 2023

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/31622

Thesis The development of viral vectors for targeted gene delivery to atherosclerotic plaques

White, Katie · 2007 · University of Glasgow · DOI

Full title: The development of viral vectors for targeted gene delivery to atherosclerotic plaques

Authors: White, Katie

Year: 2007

Venue: University of Glasgow

DOI: https://theses.gla.ac.uk/30729/1/2007WhitePhD.pdf

Thesis Conception et évaluation d’un nouveau système de transfection ciblée, basé sur l’utilisation du système E/Kcoil

Louvier, Elodie · 2016 · Université de Montréal (Papyrus) · DOI

Full title: Conception et évaluation d’un nouveau système de transfection ciblée, basé sur l’utilisation du système E/Kcoil

Authors: Louvier, Elodie

Year: 2016

Venue: Université de Montréal (Papyrus)

DOI: http://hdl.handle.net/1866/13031

Thesis Evaluation of safety and methods for production of retroviral vectors for use in gene therapy

Kewney, Caroline · 1998 · University of Glasgow · DOI

Full title: Evaluation of safety and methods for production of retroviral vectors for use in gene therapy

Authors: Kewney, Caroline

Year: 1998

Venue: University of Glasgow

DOI: https://theses.gla.ac.uk/71502/7/10391130.pdf

Thesis Développement de procédés efficaces pour la construction et la production de vecteurs adénoviraux

Gagnon, David · 2010 · Université de Montréal (Papyrus) · DOI

Full title: Développement de procédés efficaces pour la construction et la production de vecteurs adénoviraux

Authors: Gagnon, David

Year: 2010

Venue: Université de Montréal (Papyrus)

DOI: http://hdl.handle.net/1866/4462

Thesis A study of apoptosis and cell cycle to augment transfection efficiency in CHO cell lines

Wanandy, Nico Stanislaus · 2007 · UNSW Sydney · DOI

Full title: A study of apoptosis and cell cycle to augment transfection efficiency in CHO cell lines

Authors: Wanandy, Nico Stanislaus

Year: 2007

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/40868

Thesis Epi-CHO, an episomal expression system for recombinant protein production in CHO cells

Kunaparaju, Raj Kumar · 2008 · UNSW Sydney · DOI

Full title: Epi-CHO, an episomal expression system for recombinant protein production in CHO cells

Authors: Kunaparaju, Raj Kumar

Year: 2008

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/41499

Thesis Preparation and functionalization of magnetic iron oxide nanoparticles for application in gene delivery

Arsianti, Maria · 2010 · UNSW Sydney · DOI

Full title: Preparation and functionalization of magnetic iron oxide nanoparticles for application in gene delivery

Authors: Arsianti, Maria

Year: 2010

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/50261

Thesis Production de vecteurs viraux efficaces pour la transduction de cellules transformées et de cellules primaires

Pilotte, Amélie · 2016 · Université de Montréal (Papyrus) · DOI

Full title: Production de vecteurs viraux efficaces pour la transduction de cellules transformées et de cellules primaires

Authors: Pilotte, Amélie

Year: 2016

Venue: Université de Montréal (Papyrus)

DOI: http://hdl.handle.net/1866/15572

Thesis Retroviral transduction of hematopoietic stem cells : optimisation of parameters for transduction

Wotherspoon, Simon Lance · 2005 · UNSW Sydney · DOI

Full title: Retroviral transduction of hematopoietic stem cells : optimisation of parameters for transduction

Authors: Wotherspoon, Simon Lance

Year: 2005

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/66240

Thesis Development and optimization of the attB system to produce Helper-dependent Adenovirus vectors of different species

Cots i Rabella, Dan · 2014 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Development and optimization of the attB system to produce Helper-dependent Adenovirus vectors of different species

Authors: Cots i Rabella, Dan

Year: 2014

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/283431

Thesis Enhancement of virus-like particle production in HEK293 cell cultures

Fuenmayor Garcés, Javier · 2018 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Enhancement of virus-like particle production in HEK293 cell cultures

Authors: Fuenmayor Garcés, Javier

Year: 2018

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/650410

Thesis Study and characterisation of human HEK293 cell line as a platform for recombinant protein production

Liste Calleja, Leticia · 2015 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Study and characterisation of human HEK293 cell line as a platform for recombinant protein production

Authors: Liste Calleja, Leticia

Year: 2015

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/308324

Thesis Production of Virus-Like Particles in HEK 293 cells and functionalization with SARS-CoV-2

Boix i Besora, Arnau · 2022 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Production of Virus-Like Particles in HEK 293 cells and functionalization with SARS-CoV-2

Authors: Boix i Besora, Arnau

Year: 2022

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/675518

Thesis Bioprocess Engineering for HIV-1 Gag VLP Production in HEK293 Cells

Lavado García, Jesús · 2022 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Bioprocess Engineering for HIV-1 Gag VLP Production in HEK293 Cells

Authors: Lavado García, Jesús

Year: 2022

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/674392

Thesis Desarrollo de procesos de producción de proteínas bioterapéuticas: Aumento de la productividad especifica en células HEK293

Román Roldán, Ramón · 2018 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Desarrollo de procesos de producción de proteínas bioterapéuticas: Aumento de la productividad especifica en células HEK293

Authors: Román Roldán, Ramón

Year: 2018

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/650828

Thesis Strategies for improving production levels of HIV-1 VLPs by transient transfection of HEK 293 suspension cultures

Cervera Garcia, Laura · 2015 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Strategies for improving production levels of HIV-1 VLPs by transient transfection of HEK 293 suspension cultures

Authors: Cervera Garcia, Laura

Year: 2015

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/289626

Thesis Understanding the cell density effect upon transient transfection in HEK293 cell culture during HIV-1 VLP production

Pérez Rubio, Pol · 2024 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Understanding the cell density effect upon transient transfection in HEK293 cell culture during HIV-1 VLP production

Authors: Pérez Rubio, Pol

Year: 2024

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/693156

Thesis LARGE GENE DELIVERY TO THE RETINA BY MULTIPLE AAV VECTORS

TORNABENE, PATRIZIA · 2019 · Università degli Studi di Milano (AIR) · DOI

Full title: LARGE GENE DELIVERY TO THE RETINA BY MULTIPLE AAV VECTORS

Authors: TORNABENE, PATRIZIA

Year: 2019

Venue: Università degli Studi di Milano (AIR)

DOI: http://hdl.handle.net/2434/608611

Thesis Geração de clones de células HEK293 superprodutores de isoformas recombinantes de VEGF-A (Fator de Crescimento Endotelial Vascular A) humano visando à produção de biofármacos para terapia molecular e engenharia tecidual

Sogayar, Mari Cleide · 2014 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Geração de clones de células HEK293 superprodutores de isoformas recombinantes de VEGF-A (Fator de Crescimento Endotelial Vascular A) humano visando à produção de biofármacos para terapia molecular e engenharia tecidual

Authors: Sogayar, Mari Cleide

Year: 2014

Venue: Universidade de São Paulo – USP Digital Library

DOI: http://www.teses.usp.br/teses/disponiveis/46/46131/tde-01102014-145602/

Thesis A novel AAV9 random peptide library to select for endothelial cell – directed gene transfer vectors

Varadi, Karl · 2011 · Heidelberg University · DOI

Full title: A novel AAV9 random peptide library to select for endothelial cell – directed gene transfer vectors

Authors: Varadi, Karl

Year: 2011

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/12542/1/Dissertation_Karl_Varadi.pdf

Thesis Analysis of Infection Relevant Protein Domains of the Adeno-Associated Virus Serotype 8 in Comparison to Serotype 2

Raupp, Christina · 2010 · Heidelberg University · DOI

Full title: Analysis of Infection Relevant Protein Domains of the Adeno-Associated Virus Serotype 8 in Comparison to Serotype 2

Authors: Raupp, Christina

Year: 2010

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/10925/1/complete_CRAUPPdiss.pdf

Thesis Alleviation of shRNA off-target effects via rAAV vector-encoded sense strand decoys

Mockenhaupt, Stefan · 2012 · Heidelberg University · DOI

Full title: Alleviation of shRNA off-target effects via rAAV vector-encoded sense strand decoys

Authors: Mockenhaupt, Stefan

Year: 2012

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/13390/1/Mockenhaupt_PhD_thesis_final.pdf

Thesis With small viruses come giant responsibilities - Next-generation parvoviral vectors for human gene therapy with extended packaging capacity and enhanced safety profile

Fakhiri, Julia · 2019 · Heidelberg University · DOI

Full title: With small viruses come giant responsibilities - Next-generation parvoviral vectors for human gene therapy with extended packaging capacity and enhanced safety profile

Authors: Fakhiri, Julia

Year: 2019

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/27326/1/PhD%20thesis%20Julia%20Fakhiri.pdf

Thesis Evaluating Lung Gene Therapy Viral Vector Platforms using Precision-cut Lung Slices as an ex vivo Model

Stevens, Brenna · 2025 · University of Guelph · DOI

Full title: Evaluating Lung Gene Therapy Viral Vector Platforms using Precision-cut Lung Slices as an ex vivo Model

Authors: Stevens, Brenna

Year: 2025

Venue: University of Guelph

DOI: https://hdl.handle.net/10214/29367

Thesis Glyco-engineered HEK 293-F cell lines to produce therapeutic glycoproteins with human N-glycosylation and improved pharmacokinetics

Uhler, Rico · 2022 · Heidelberg University · DOI

Full title: Glyco-engineered HEK 293-F cell lines to produce therapeutic glycoproteins with human N-glycosylation and improved pharmacokinetics

Authors: Uhler, Rico

Year: 2022

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/31087/1/PhD%20Thesis%20Rico%20Uhler.pdf

Thesis Charakterisierung eines parvoviralen Hybridvektors hinsichtlich der Transduktion und präferentiellen Expression in transformierten Zellen

Krüger, Lars · 2005 · Heidelberg University · DOI

Full title: Charakterisierung eines parvoviralen Hybridvektors hinsichtlich der Transduktion und präferentiellen Expression in transformierten Zellen

Authors: Krüger, Lars

Year: 2005

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/5635/1/Dissertation_LK.pdf

Thesis Targeted lentiviral vectors pseudotyped with the Tupaia paramyxovirus glycoproteins

Enkirch, Theresa · 2011 · Heidelberg University · DOI

Full title: Targeted lentiviral vectors pseudotyped with the Tupaia paramyxovirus glycoproteins

Authors: Enkirch, Theresa

Year: 2011

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/12946/1/DrArbeit_FINAL_Theresa.pdf

Thesis One for all, all for one: Combining and improving AAV, RNAi and CRISPR technologies to combat HBV infection and HBV/HDV co-infections

Schmelas, Carolin · 2020 · Heidelberg University · DOI

Full title: One for all, all for one: Combining and improving AAV, RNAi and CRISPR technologies to combat HBV infection and HBV/HDV co-infections

Authors: Schmelas, Carolin

Year: 2020

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/28513/1/Schmelas_Dissertation.pdf

Thesis Rekombinante Hepatitis B Viren-Vektoren als Werkzeuge für Molekularbiologie und Therapie : Optimierung eines Systems

Untergasser, Andreas · 2003 · Heidelberg University · DOI

Full title: Rekombinante Hepatitis B Viren-Vektoren als Werkzeuge für Molekularbiologie und Therapie : Optimierung eines Systems

Authors: Untergasser, Andreas

Year: 2003

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/3121/1/Promotion.pdf

Thesis Engineering inducible cell lines for recombinant Adeno-Associated Virus production

Lee, Zion · 2021 · University of Minnesota - Digital Conservancy · DOI

Full title: Engineering inducible cell lines for recombinant Adeno-Associated Virus production

Authors: Lee, Zion

Year: 2021

Venue: University of Minnesota - Digital Conservancy

DOI: https://hdl.handle.net/11299/225020

Thesis Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Murayyan, Abdulmonem · 2013 · University of Guelph · DOI

Full title: Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Authors: Murayyan, Abdulmonem

Year: 2013

Venue: University of Guelph

DOI: http://hdl.handle.net/10214/6604

Thesis AAV-Vectored Immunoprophylaxis for the Prevention and Treatment of Infectious Diseases

Rghei, Amira · 2022 · University of Guelph · DOI

Full title: AAV-Vectored Immunoprophylaxis for the Prevention and Treatment of Infectious Diseases

Authors: Rghei, Amira

Year: 2022

Venue: University of Guelph

DOI: https://hdl.handle.net/10214/27116

Thesis Optimizing an Adeno-Associated Virus Vector System for Monogenic Diseases: Promoter Discovery and In Vivo Dosing Insights from a Neonatal Pig Model

Zielinska, Nicole · 2025 · University of Guelph · DOI

Full title: Optimizing an Adeno-Associated Virus Vector System for Monogenic Diseases: Promoter Discovery and In Vivo Dosing Insights from a Neonatal Pig Model

Authors: Zielinska, Nicole

Year: 2025

Venue: University of Guelph

DOI: https://hdl.handle.net/10214/29254

Thesis Adeno-Associated Virus Vector Development for Monoclonal Antibody Expression to Prevent Ebola Virus Infection

van Lieshout, Laura · 2018 · University of Guelph · DOI

Full title: Adeno-Associated Virus Vector Development for Monoclonal Antibody Expression to Prevent Ebola Virus Infection

Authors: van Lieshout, Laura

Year: 2018

Venue: University of Guelph

DOI: http://hdl.handle.net/10214/14680

Thesis Novel Extracellular Vesicle Modalities for Delivery of Genome Editor Ribonucleoprotein Complexes

Cabeceiras, Peter Keith · 2022 · Harvard University - DASH · DOI

Full title: Novel Extracellular Vesicle Modalities for Delivery of Genome Editor Ribonucleoprotein Complexes

Authors: Cabeceiras, Peter Keith

Year: 2022

Venue: Harvard University - DASH

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372269

Thesis Factors affecting AAV production: Mutagenesis of AAV2 rep and AAV transgenes

Jain, Nina Kumari · 2024 · Harvard University - DASH · DOI

Full title: Factors affecting AAV production: Mutagenesis of AAV2 rep and AAV transgenes

Authors: Jain, Nina Kumari

Year: 2024

Venue: Harvard University - DASH

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37377871

Thesis Novel High-Throughput Methods to Study AAV Immunity Using Combinatorial Capsid Libraries

Schmit, Pauline Frances · 2021 · Harvard University - DASH · DOI

Full title: Novel High-Throughput Methods to Study AAV Immunity Using Combinatorial Capsid Libraries

Authors: Schmit, Pauline Frances

Year: 2021

Venue: Harvard University - DASH

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369455

Thesis Advanced Process Development in Gene and Cell Therapies

Ladd, Brian · 2025 · KTH Royal Institute of Technology · DOI

Full title: Advanced Process Development in Gene and Cell Therapies

Authors: Ladd, Brian

Year: 2025

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-360154

Thesis Structural, Viral, and Host Factors of Adeno-Associated Virus Assembly

Maurer, Anna · 2019 · Harvard University - DASH · DOI

Full title: Structural, Viral, and Host Factors of Adeno-Associated Virus Assembly

Authors: Maurer, Anna

Year: 2019

Venue: Harvard University - DASH

DOI: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42029713

Thesis In Vivo Delivery and Therapeutic Applications of Base Editors

Yeh, Ariel (Wei-Hsi) · 2020 · Harvard University - DASH · DOI

Full title: In Vivo Delivery and Therapeutic Applications of Base Editors

Authors: Yeh, Ariel (Wei-Hsi)

Year: 2020

Venue: Harvard University - DASH

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37365751

Thesis Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022 · KTH Royal Institute of Technology · DOI

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

Year: 2022

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis Production and pharmaceutical formulation of plasmid DNA vaccines

van der Heijden, I. · 2013 · Utrecht University · DOI

Full title: Production and pharmaceutical formulation of plasmid DNA vaccines

Authors: van der Heijden, I.

Year: 2013

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/283165

Thesis Formulation and delivery of dermal DNA vaccines

van den Berg, J.H. · 2009 · Utrecht University · DOI

Full title: Formulation and delivery of dermal DNA vaccines

Authors: van den Berg, J.H.

Year: 2009

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/36212

Thesis Highly efficient Cas9 mediated transcriptional programming and delivery via Adeno-Associated Virus

Vora, Suhani · 2017 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Highly efficient Cas9 mediated transcriptional programming and delivery via Adeno-Associated Virus

Authors: Vora, Suhani

Year: 2017

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/112508

Thesis Systems Engineering for Viral Vector Manufacturing

Nguyen, Tam Ngoc Thanh · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Systems Engineering for Viral Vector Manufacturing

Authors: Nguyen, Tam Ngoc Thanh

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/150243

Thesis Efficacy and toxicity of linear polyamidoamine polymers used in gene delivery

Almulathanon, Ammar · 2018 · University of Nottingham · DOI

Full title: Efficacy and toxicity of linear polyamidoamine polymers used in gene delivery

Authors: Almulathanon, Ammar

Year: 2018

Venue: University of Nottingham

DOI: https://eprints.nottingham.ac.uk/49894/1/Ammar%20thesis.pdf

Thesis Quantitative analysis of non-viral gene therapy in primary liver culture systems

Tedford, Nathan C · 2008 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Quantitative analysis of non-viral gene therapy in primary liver culture systems

Authors: Tedford, Nathan C

Year: 2008

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/39914

Thesis Optimisation of Delivery of the Ataxia Telangiectasia Mutated Transgene to HeLa Cells Using Glycosaminoglycan Enhanced Transduction

Siam, Ala'a · 2021 · University of Nottingham · DOI

Full title: Optimisation of Delivery of the Ataxia Telangiectasia Mutated Transgene to HeLa Cells Using Glycosaminoglycan Enhanced Transduction

Authors: Siam, Ala'a

Year: 2021

Venue: University of Nottingham

DOI: https://eprints.nottingham.ac.uk/66891/1/Ala%27a%20Siam%20-%20MRes%20Thesis.pdf

Thesis Modified cell penetrating peptides for efficient gene transfer in vitro and in vivo

Osman, Gizem · 2017 · University of Nottingham · DOI

Full title: Modified cell penetrating peptides for efficient gene transfer in vitro and in vivo

Authors: Osman, Gizem

Year: 2017

Venue: University of Nottingham

DOI: https://eprints.nottingham.ac.uk/41863/1/00%20MASTER%20-%20G.Osman.pdf

Thesis Scalable Production of Genome-Edited Livestock Embryos

Lin, Jason Chen · 2022 · University of California, Davis · DOI

Full title: Scalable Production of Genome-Edited Livestock Embryos

Authors: Lin, Jason Chen

Year: 2022

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/8hs7x39z

Thesis Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Cosenza, Zachary Anthony · 2022 · University of California, Davis · DOI

Full title: Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Authors: Cosenza, Zachary Anthony

Year: 2022

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/119489fc

Thesis Construction and characterization of stable cell lines that generate recombinant adeno-associated virus (rAAV) /

Voulgaropoulou, Frosso · 1996 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Construction and characterization of stable cell lines that generate recombinant adeno-associated virus (rAAV) /

Authors: Voulgaropoulou, Frosso

Year: 1996

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1487942476408687

Thesis Genetic Modification of Adeno-Associated Virus Capsid for Enhanced Motor Neuron Delivery and Retrograde Transport

Davis, Adam Scott · 2012 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Genetic Modification of Adeno-Associated Virus Capsid for Enhanced Motor Neuron Delivery and Retrograde Transport

Authors: Davis, Adam Scott

Year: 2012

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1351693788

Thesis White-Box Approaches to Cell Culture Media Optimization for Cultivated Meat

O'Neill, Edward N · 2024 · University of California, Davis · DOI

Full title: White-Box Approaches to Cell Culture Media Optimization for Cultivated Meat

Authors: O'Neill, Edward N

Year: 2024

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/9920t5d7

Thesis Derivation of rep-positive adeno-associated virus vectors and analysis of site-specific integration /

Philpott, Jessica R. · 2000 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Derivation of rep-positive adeno-associated virus vectors and analysis of site-specific integration /

Authors: Philpott, Jessica R.

Year: 2000

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1488192119261715

Thesis Identification and Validation of Target Receptors/Transporters for AAV9

Roach, Matthew · 2023 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Identification and Validation of Target Receptors/Transporters for AAV9

Authors: Roach, Matthew

Year: 2023

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/33782/1/MatthewRoach_PhD_Thesis_with_corrections_MR%20edit.pdf

Thesis Development of new strategies for efficient production and purification of recombinant adeno-associated virus (rAAV) vector /

Liu, Xingluo · 1999 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Development of new strategies for efficient production and purification of recombinant adeno-associated virus (rAAV) vector /

Authors: Liu, Xingluo

Year: 1999

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1488187049541563

Thesis Optimising adeno associated virus mediated gene therapy

Mallik, Shreyashee · 2023 · University of Sydney · DOI

Full title: Optimising adeno associated virus mediated gene therapy

Authors: Mallik, Shreyashee

Year: 2023

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/31477

Thesis Development and characterization of an improved formulation of cholesteryl oleate-loaded cationic solid-lipid nanoparticles as an efficient non-viral gene delivery system

Limeres, María José; Suñé-Pou, Marc; Prieto-Sánchez, Silvia et al. · 2019 · National University of La Plata – SeDiCI · DOI

Full title: Development and characterization of an improved formulation of cholesteryl oleate-loaded cationic solid-lipid nanoparticles as an efficient non-viral gene delivery system

Authors: Limeres, María José; Suñé-Pou, Marc; Prieto-Sánchez, Silvia; Moreno-Castro, Cristina; Nusblat, Alejandro D.; Hernández-Munain, Cristina; Castro, Guillermo Raúl; Suñé, Carlos; Suñé-Negre, Josep M.; Cuestas, María Luján

Year: 2019

Venue: National University of La Plata – SeDiCI

DOI: http://sedici.unlp.edu.ar/handle/10915/139683

Thesis Produção de vetores lentivirais baseados em HIV-1 em linhagem de célula tronco mesenquimal murina

Silva, Flávia Helena da · 2007 · Universidade Federal do Rio Grande do Sul – LUME · DOI

Full title: Produção de vetores lentivirais baseados em HIV-1 em linhagem de célula tronco mesenquimal murina

Authors: Silva, Flávia Helena da

Year: 2007

Venue: Universidade Federal do Rio Grande do Sul – LUME

DOI: http://hdl.handle.net/10183/8134

Thesis Design of a Novel Gene Therapy Construct to Achieve Sustained Brain-Derived Neurotrophic Factor Signaling in Neurons.

Osborne, Andrew; Wang, Aiden XZ; Tassoni, Alessia et al. · 2018 · University of Cambridge · DOI

Full title: Design of a Novel Gene Therapy Construct to Achieve Sustained Brain-Derived Neurotrophic Factor Signaling in Neurons.

Authors: Osborne, Andrew; Wang, Aiden XZ; Tassoni, Alessia; Widdowson, Peter S; Martin, Keith R

Year: 2018

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/274008

Thesis Adeno-associated virus rep78 expression in Arabidopsis thaliana

Sisco, Daniel · 2011 · Virginia Tech - VTechWorks · DOI

Full title: Adeno-associated virus rep78 expression in Arabidopsis thaliana

Authors: Sisco, Daniel

Year: 2011

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/9706

Thesis A Mechanistic Dissection of Polyethylenimine Mediated Transfection of Chinese Hamster Ovary Cells

Mozley, O L · 2013 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: A Mechanistic Dissection of Polyethylenimine Mediated Transfection of Chinese Hamster Ovary Cells

Authors: Mozley, O L

Year: 2013

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/5593/1/A%20mechanistic%20dissection%20of%20polyethylenimine%20mediated%20transfection%20of%20chinese%20hamster%20ovary%20cells.pdf

Thesis Optimalizace rekombinantní exprese proteinů v lidské buněčné linii HEK293

Murajdová, Viktória · 2024 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Optimalizace rekombinantní exprese proteinů v lidské buněčné linii HEK293

Authors: Murajdová, Viktória

Year: 2024

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/194250

Thesis Transient recombinant protein expression in mammalian cells : the role of mRNA level and stability

Wulhfard, Sarah · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transient recombinant protein expression in mammalian cells : the role of mRNA level and stability

Authors: Wulhfard, Sarah

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/36998

Thesis DEAE-Dextran Enhances the Lentiviral Transduction of Primary Human Mesenchymal Stromal Cells from All Major Tissue Sources Without Affecting Their Proliferation and Phenotype

Amadeo, Francesco; Hanson, Vivien; Murray, Patricia et al. · 2023 · University of Liverpool · DOI

Full title: DEAE-Dextran Enhances the Lentiviral Transduction of Primary Human Mesenchymal Stromal Cells from All Major Tissue Sources Without Affecting Their Proliferation and Phenotype

Authors: Amadeo, Francesco; Hanson, Vivien; Murray, Patricia; Taylor, Arthur

Year: 2023

Venue: University of Liverpool

DOI: https://livrepository.liverpool.ac.uk/3162174/1/library.pdf

Thesis Untersuchung der zellspezifischen In-situ-Effizienz des Nukleinsäuretransfers in das Herzgewebe

Liu, Zihou · 2021 · Freie Universität Berlin (Refubium) · DOI

Full title: Untersuchung der zellspezifischen In-situ-Effizienz des Nukleinsäuretransfers in das Herzgewebe

Authors: Liu, Zihou

Year: 2021

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/31132

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Metadata only

Paper Inducible HEK293 AAV packaging cell lines expressing Rep proteins.

Jalšić, Lovro; Lytvyn, Viktoria; Elahi, Seyyed Mehdy et al. · 2023 · Molecular therapy. Methods & clinical development · DOI

Full title: Inducible HEK293 AAV packaging cell lines expressing Rep proteins.

Authors: Jalšić, Lovro; Lytvyn, Viktoria; Elahi, Seyyed Mehdy; Hrapovic, Sabahudin; Nassoury, Nasha; Chahal, Parminder Singh; Gaillet, Bruno; Gilbert, Rénald

Year: 2023

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2023.07.002

Paper Production of rVSV-ZEBOV in serum-free suspension culture of HEK 293SF cells

Gélinas, Jean‐François; Azizi, Hiva; Kießlich, Sascha et al. · 2019 · Vaccine · DOI

Full title: Production of rVSV-ZEBOV in serum-free suspension culture of HEK 293SF cells

Authors: Gélinas, Jean‐François; Azizi, Hiva; Kießlich, Sascha; Lanthier, Stéphane; Perdersen, Jannie; Chahal, Parminder S.; Ansorge, Sven; Kobinger, Gary; Gilbert, Rénald; Kamen, Amine

Year: 2019

Venue: Vaccine

DOI: https://doi.org/10.1016/j.vaccine.2019.09.044

Paper Improving viral-based gene delivery to mammalian cells through simple co-incubation with transportan peptide in vitro.

Wang, Nianwu; Hu, Xiangxiang; Pang, Hong-Bo · 2025 · Journal of pharmaceutical sciences · DOI

Full title: Improving viral-based gene delivery to mammalian cells through simple co-incubation with transportan peptide in vitro.

Authors: Wang, Nianwu; Hu, Xiangxiang; Pang, Hong-Bo

Year: 2025

Venue: Journal of pharmaceutical sciences

DOI: https://doi.org/10.1016/j.xphs.2025.103920

Paper Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences.

Trivedi, Prasad D; Yu, Chenghui; Chaudhuri, Payel et al. · 2022 · Molecular therapy. Methods & clinical development · DOI

Full title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences.

Authors: Trivedi, Prasad D; Yu, Chenghui; Chaudhuri, Payel; Johnson, Evan J; Caton, Tina; Adamson, Laura; Byrne, Barry J; Paulk, Nicole K; Clément, Nathalie

Year: 2022

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2021.12.006

Paper Establishment of a novel human amniotic epithelial-derived cell line, HAT, for high-yield AAV vector production.

Hirai, Yugo; Chang, Yu-Hsin; Yamamoto, Arisa et al. · 2025 · Molecular therapy. Methods & clinical development · DOI

Full title: Establishment of a novel human amniotic epithelial-derived cell line, HAT, for high-yield AAV vector production.

Authors: Hirai, Yugo; Chang, Yu-Hsin; Yamamoto, Arisa; Asahina, Ryo; Moromizato, Rena; Kinoshita, Mawo; Aizawa, Kazuko; Miyai, Manami; Kubota, Michi; Horiuchi, Takayuki; Nakamura, Kazuaki

Year: 2025

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2025.101594

Paper Efficient production of recombinant adeno-associated viral vector, serotype DJ/8, carrying the GFP gene.

Hashimoto, Haruo; Mizushima, Tomoko; Chijiwa, Tsuyoshi et al. · 2017 · Virus research · DOI

Full title: Efficient production of recombinant adeno-associated viral vector, serotype DJ/8, carrying the GFP gene.

Authors: Hashimoto, Haruo; Mizushima, Tomoko; Chijiwa, Tsuyoshi; Nakamura, Masato; Suemizu, Hiroshi

Year: 2017

Venue: Virus research

DOI: https://doi.org/10.1016/j.virusres.2017.05.017

Paper Suppression of toxic transgene expression by optimized artificial miRNAs increases AAV vector yields in HEK-293 cells.

Blahetek, Gina; Mayer, Christine; Zuber, Johannes et al. · 2024 · Molecular therapy. Methods & clinical development · DOI

Full title: Suppression of toxic transgene expression by optimized artificial miRNAs increases AAV vector yields in HEK-293 cells.

Authors: Blahetek, Gina; Mayer, Christine; Zuber, Johannes; Lenter, Martin; Strobel, Benjamin

Year: 2024

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2024.101280

Paper Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection.

Liu, Hao; Zhang, Yue; Yip, Mitchell et al. · 2024 · Molecular therapy. Methods & clinical development · DOI

Full title: Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection.

Authors: Liu, Hao; Zhang, Yue; Yip, Mitchell; Ren, Lingzhi; Liang, Jialing; Chen, Xiupeng; Liu, Nan; Du, Ailing; Wang, Jiaming; Chang, Hao; Oh, Hyejin; Zhou, Chen; Xing, Ruxiao; Xu, Mengyao; Guo, Peiyi; Gessler, Dominic; Xie, Jun; Tai, Phillip W L; Gao, Guangping; Wang, Dan

Year: 2024

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2024.101230

Paper Enhanced AAV production via rational design of a novel pHelper vector integrated with HSV-1 helper genes.

Ren, He; Nie, Jianqi; Song, Zichuan et al. · 2026 · Synthetic and systems biotechnology · DOI

Full title: Enhanced AAV production via rational design of a novel pHelper vector integrated with HSV-1 helper genes.

Authors: Ren, He; Nie, Jianqi; Song, Zichuan; Mo, Wanting; Yang, Yankun; Bai, Zhonghu

Year: 2026

Venue: Synthetic and systems biotechnology

DOI: https://doi.org/10.1016/j.synbio.2025.12.018

Paper Multi-omics driven genome-scale metabolic modeling improves viral vector yield in HEK293.

Zehetner, L; Széliová, D; Kraus, B et al. · 2025 · Metabolic engineering · DOI

Full title: Multi-omics driven genome-scale metabolic modeling improves viral vector yield in HEK293.

Authors: Zehetner, L; Széliová, D; Kraus, B; Hernandez Bort, J A; Zanghellini, J

Year: 2025

Venue: Metabolic engineering

DOI: https://doi.org/10.1016/j.ymben.2025.03.011

Paper An efficient rHSV-based complementation system for the production of multiple rAAV vector serotypes.

Kang, W; Wang, L; Harrell, H et al. · 2009 · Gene therapy · DOI

Full title: An efficient rHSV-based complementation system for the production of multiple rAAV vector serotypes.

Authors: Kang, W; Wang, L; Harrell, H; Liu, J; Thomas, D L; Mayfield, T L; Scotti, M M; Ye, G J; Veres, G; Knop, D R

Year: 2009

Venue: Gene therapy

DOI: https://doi.org/10.1038/gt.2008.158

Paper Interplay between Triadin and Calsequestrin in the Pathogenesis of CPVT in the Mouse.

Cacheux, Marine; Fauconnier, Jérémy; Thireau, Jérôme et al. · 2020 · Molecular therapy : the journal of the American Society of Gene Therapy · DOI

Full title: Interplay between Triadin and Calsequestrin in the Pathogenesis of CPVT in the Mouse.

Authors: Cacheux, Marine; Fauconnier, Jérémy; Thireau, Jérôme; Osseni, Alexis; Brocard, Jacques; Roux-Buisson, Nathalie; Brocard, Julie; Fauré, Julien; Lacampagne, Alain; Marty, Isabelle

Year: 2020

Venue: Molecular therapy : the journal of the American Society of Gene Therapy

DOI: https://doi.org/10.1016/j.ymthe.2019.09.012

Paper Characterization of a spontaneously generated murine retinal pigmented epithelium cell line; a model for in vitro experiments.

Ranaei Pirmardan, Ehsan; Soheili, Zahra-Soheila; Samiei, Shahram et al. · 2016 · Experimental cell research · DOI

Full title: Characterization of a spontaneously generated murine retinal pigmented epithelium cell line; a model for in vitro experiments.

Authors: Ranaei Pirmardan, Ehsan; Soheili, Zahra-Soheila; Samiei, Shahram; Ahmadieh, Hamid; Mowla, Seyed Javad; Ezzati, Razie; Naseri, Marzieh

Year: 2016

Venue: Experimental cell research

DOI: https://doi.org/10.1016/j.yexcr.2016.08.015

Paper Systematic comparison of rAAV vectors manufactured using large-scale suspension cultures of Sf9 and HEK293 cells.

Liu, Shengjiang; Li, Jinzhong; Peraramelli, Sameera et al. · 2024 · Molecular therapy : the journal of the American Society of Gene Therapy · DOI

Full title: Systematic comparison of rAAV vectors manufactured using large-scale suspension cultures of Sf9 and HEK293 cells.

Authors: Liu, Shengjiang; Li, Jinzhong; Peraramelli, Sameera; Luo, Ningguang; Chen, Alan; Dai, Minghua; Liu, Fang; Yu, Yanbao; Leib, Ryan D; Li, Ying; Lin, Kevin; Huynh, Derrick; Li, Shuyi; Ou, Li

Year: 2024

Venue: Molecular therapy : the journal of the American Society of Gene Therapy

DOI: https://doi.org/10.1016/j.ymthe.2023.11.022

Paper Integration of adeno-associated virus-derived peptides into nonviral vectors to synergistically enhance cellular transfection.

Kim, Jung-Suk; Kim, Eunmi; Oh, Ji-Seon et al. · 2013 · Biomacromolecules · DOI

Full title: Integration of adeno-associated virus-derived peptides into nonviral vectors to synergistically enhance cellular transfection.

Authors: Kim, Jung-Suk; Kim, Eunmi; Oh, Ji-Seon; Jang, Jae-Hyung

Year: 2013

Venue: Biomacromolecules

DOI: https://doi.org/10.1021/bm4005854

Paper Clearance and characterization of residual HSV DNA in recombinant adeno-associated virus produced by an HSV complementation system.

Ye, G-J; Scotti, M M; Liu, J et al. · 2011 · Gene therapy · DOI

Full title: Clearance and characterization of residual HSV DNA in recombinant adeno-associated virus produced by an HSV complementation system.

Authors: Ye, G-J; Scotti, M M; Liu, J; Wang, L; Knop, D R; Veres, G

Year: 2011

Venue: Gene therapy

DOI: https://doi.org/10.1038/gt.2010.102

Paper Different protein composition and functional properties of adeno-associated virus-6 vector manufactured from the culture medium and cell lysates.

Denard, Jerome; Jenny, Christine; Blouin, Véronique et al. · 2014 · Molecular therapy. Methods & clinical development · DOI

Full title: Different protein composition and functional properties of adeno-associated virus-6 vector manufactured from the culture medium and cell lysates.

Authors: Denard, Jerome; Jenny, Christine; Blouin, Véronique; Moullier, Philippe; Svinartchouk, Fedor

Year: 2014

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1038/mtm.2014.31

Paper Ultracentrifugation-free chromatography-mediated large-scale purification of recombinant adeno-associated virus serotype 1 (rAAV1).

Tomono, Taro; Hirai, Yukihiko; Okada, Hironori et al. · 2016 · Molecular therapy. Methods & clinical development · DOI

Full title: Ultracentrifugation-free chromatography-mediated large-scale purification of recombinant adeno-associated virus serotype 1 (rAAV1).

Authors: Tomono, Taro; Hirai, Yukihiko; Okada, Hironori; Adachi, Kumi; Ishii, Akiko; Shimada, Takashi; Onodera, Masafumi; Tamaoka, Akira; Okada, Takashi

Year: 2016

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1038/mtm.2015.58

Paper Delivering multiple gene products in the brain from a single adeno-associated virus vector.

Foti, S B; Samulski, R J; McCown, T J · 2009 · Gene therapy · DOI

Full title: Delivering multiple gene products in the brain from a single adeno-associated virus vector.

Authors: Foti, S B; Samulski, R J; McCown, T J

Year: 2009

Venue: Gene therapy

DOI: https://doi.org/10.1038/gt.2009.106

Paper Production of Recombinant Adeno-associated Virus Vectors Using Suspension HEK293 Cells and Continuous Harvest of Vector From the Culture Media for GMP FIX and FLT1 Clinical Vector.

Grieger, Joshua C; Soltys, Stephen M; Samulski, Richard Jude · 2016 · Molecular therapy : the journal of the American Society of Gene Therapy · DOI

Full title: Production of Recombinant Adeno-associated Virus Vectors Using Suspension HEK293 Cells and Continuous Harvest of Vector From the Culture Media for GMP FIX and FLT1 Clinical Vector.

Authors: Grieger, Joshua C; Soltys, Stephen M; Samulski, Richard Jude

Year: 2016

Venue: Molecular therapy : the journal of the American Society of Gene Therapy

DOI: https://doi.org/10.1038/mt.2015.187

Paper Corticospinal tract transduction: a comparison of seven adeno-associated viral vector serotypes and a non-integrating lentiviral vector.

Hutson, T H; Verhaagen, J; Yáñez-Muñoz, R J et al. · 2012 · Gene therapy · DOI

Full title: Corticospinal tract transduction: a comparison of seven adeno-associated viral vector serotypes and a non-integrating lentiviral vector.

Authors: Hutson, T H; Verhaagen, J; Yáñez-Muñoz, R J; Moon, L D F

Year: 2012

Venue: Gene therapy

DOI: https://doi.org/10.1038/gt.2011.71

Paper Improvement in the suspension-culture production of recombinant adeno-associated virus-LacZ in HEK-293 cells using polyethyleneimine-DNA complexes in combination with hypothermic treatment.

Feng, Lei; Guo, Meijin; Zhang, Shuxiang et al. · 2008 · Biotechnology and applied biochemistry · DOI

Full title: Improvement in the suspension-culture production of recombinant adeno-associated virus-LacZ in HEK-293 cells using polyethyleneimine-DNA complexes in combination with hypothermic treatment.

Authors: Feng, Lei; Guo, Meijin; Zhang, Shuxiang; Chu, Ju; Zhuang, Yingping; Zhang, Siliang

Year: 2008

Venue: Biotechnology and applied biochemistry

DOI: https://doi.org/10.1042/BA20070081

Paper Optimization of transfection mediated by calcium phosphate for plasmid rAAV-LacZ (recombinant adeno-associated virus-beta-galactosidase reporter gene) production in suspension-cultured HEK-293 (human embryonic kidney 293) cells.

Feng, Lei; Guo, Meijin; Zhang, Shuxiang et al. · 2007 · Biotechnology and applied biochemistry · DOI

Full title: Optimization of transfection mediated by calcium phosphate for plasmid rAAV-LacZ (recombinant adeno-associated virus-beta-galactosidase reporter gene) production in suspension-cultured HEK-293 (human embryonic kidney 293) cells.

Authors: Feng, Lei; Guo, Meijin; Zhang, Shuxiang; Chu, Ju; Zhuang, Yingping; Zhang, Siliang

Year: 2007

Venue: Biotechnology and applied biochemistry

DOI: https://doi.org/10.1042/BA20060143

Paper Insect cells as a factory to produce adeno-associated virus type 2 vectors.

Urabe, Masashi; Ding, Chuantian; Kotin, Robert M · 2002 · Human gene therapy · DOI

Full title: Insect cells as a factory to produce adeno-associated virus type 2 vectors.

Authors: Urabe, Masashi; Ding, Chuantian; Kotin, Robert M

Year: 2002

Venue: Human gene therapy

DOI: https://doi.org/10.1089/10430340260355347

Paper Sodium Chloride Enhances Recombinant Adeno-Associated Virus Production in a Serum-Free Suspension Manufacturing Platform Using the Herpes Simplex Virus System.

Adamson-Small, Laura; Potter, Mark; Byrne, Barry J et al. · 2017 · Human gene therapy methods · DOI

Full title: Sodium Chloride Enhances Recombinant Adeno-Associated Virus Production in a Serum-Free Suspension Manufacturing Platform Using the Herpes Simplex Virus System.

Authors: Adamson-Small, Laura; Potter, Mark; Byrne, Barry J; Clément, Nathalie

Year: 2017

Venue: Human gene therapy methods

DOI: https://doi.org/10.1089/hgtb.2016.151

Paper Copackaging of multiple adeno-associated viral vectors in a single production step.

Doerfler, Phillip A; Byrne, Barry J; Clément, Nathalie · 2014 · Human gene therapy methods · DOI

Full title: Copackaging of multiple adeno-associated viral vectors in a single production step.

Authors: Doerfler, Phillip A; Byrne, Barry J; Clément, Nathalie

Year: 2014

Venue: Human gene therapy methods

DOI: https://doi.org/10.1089/hgtb.2014.055

Paper Continuous Collection of Adeno-Associated Virus from Producer Cell Medium Significantly Increases Total Viral Yield.

Benskey, Matthew J; Sandoval, Ivette M; Manfredsson, Fredric P · 2016 · Human gene therapy methods · DOI

Full title: Continuous Collection of Adeno-Associated Virus from Producer Cell Medium Significantly Increases Total Viral Yield.

Authors: Benskey, Matthew J; Sandoval, Ivette M; Manfredsson, Fredric P

Year: 2016

Venue: Human gene therapy methods

DOI: https://doi.org/10.1089/hgtb.2015.117

Paper Development and Optimization of AAV hFIX Particles by Transient Transfection in an iCELLis(®) Fixed-Bed Bioreactor.

Powers, Alicia D; Piras, Bryan A; Clark, Robert K et al. · 2016 · Human gene therapy methods · DOI

Full title: Development and Optimization of AAV hFIX Particles by Transient Transfection in an iCELLis(®) Fixed-Bed Bioreactor.

Authors: Powers, Alicia D; Piras, Bryan A; Clark, Robert K; Lockey, Timothy D; Meagher, Michael M

Year: 2016

Venue: Human gene therapy methods

DOI: https://doi.org/10.1089/hgtb.2016.021

Paper Formation of newly synthesized adeno-associated virus capsids in the cell nucleus.

Bell, Peter; Vandenberghe, Luk H; Wilson, James M · 2014 · Human gene therapy methods · DOI

Full title: Formation of newly synthesized adeno-associated virus capsids in the cell nucleus.

Authors: Bell, Peter; Vandenberghe, Luk H; Wilson, James M

Year: 2014

Venue: Human gene therapy methods

DOI: https://doi.org/10.1089/hgtb.2014.054

Paper Standardized, Scalable, and Timely Flexible Adeno-Associated Virus Vector Production Using Frozen High-Density HEK-293 Cell Stocks and CELLdiscs.

Strobel, Benjamin; Zuckschwerdt, Kai; Zimmermann, Gudrun et al. · 2019 · Human gene therapy methods · DOI

Full title: Standardized, Scalable, and Timely Flexible Adeno-Associated Virus Vector Production Using Frozen High-Density HEK-293 Cell Stocks and CELLdiscs.

Authors: Strobel, Benjamin; Zuckschwerdt, Kai; Zimmermann, Gudrun; Mayer, Christine; Eytner, Ruth; Rechtsteiner, Philipp; Kreuz, Sebastian; Lamla, Thorsten

Year: 2019

Venue: Human gene therapy methods

DOI: https://doi.org/10.1089/hgtb.2018.228

Paper Dynamic imaging of pancreatic nuclear factor κB (NF-κB) activation in live mice using adeno-associated virus (AAV) infusion and bioluminescence.

Orabi, Abrahim I; Sah, Swati; Javed, Tanveer A et al. · 2015 · The Journal of biological chemistry · DOI

Full title: Dynamic imaging of pancreatic nuclear factor κB (NF-κB) activation in live mice using adeno-associated virus (AAV) infusion and bioluminescence.

Authors: Orabi, Abrahim I; Sah, Swati; Javed, Tanveer A; Lemon, Kathryn L; Good, Misty L; Guo, Ping; Xiao, Xiangwei; Prasadan, Krishna; Gittes, George K; Jin, Shunqian; Husain, Sohail Z

Year: 2015

Venue: The Journal of biological chemistry

DOI: https://doi.org/10.1074/jbc.M115.647933

Paper Scalable Lentiviral Vector Production Using Stable HEK293SF Producer Cell Lines

Manceur, Aziza; Kim, Howard S.; Misic, Vanja et al. · 2017 · Human Gene Therapy Methods · DOI

Full title: Scalable Lentiviral Vector Production Using Stable HEK293SF Producer Cell Lines

Authors: Manceur, Aziza; Kim, Howard S.; Misic, Vanja; Andreev, Nadejda; Dorion-Thibaudeau, July; Lanthier, Stéphane; Bernier, Alice; Tremblay, Sonia; Gélinas, Anne-Marie; Broussau, Sophie; Gilbert, Rénald; Ansorge, Sven

Year: 2017

Venue: Human Gene Therapy Methods

DOI: https://doi.org/10.1089/hgtb.2017.086

Paper Efficient production of dual recombinant adeno-associated viral vectors for factor VIII delivery.

Wang, Qizhao; Dong, Biao; Firrman, Jenni et al. · 2014 · Human gene therapy methods · DOI

Full title: Efficient production of dual recombinant adeno-associated viral vectors for factor VIII delivery.

Authors: Wang, Qizhao; Dong, Biao; Firrman, Jenni; Roberts, Sean; Moore, Andrea Rossi; Cao, Wenjing; Diao, Yong; Kapranov, Philipp; Xu, Ruian; Xiao, Weidong

Year: 2014

Venue: Human gene therapy methods

DOI: https://doi.org/10.1089/hgtb.2014.093

Paper Preclinical evaluation of a recombinant adeno-associated virus vector expressing human alpha-1 antitrypsin made using a recombinant herpes simplex virus production method.

Chulay, Jeffrey D; Ye, Guo-Jie; Thomas, Darby L et al. · 2011 · Human gene therapy · DOI

Full title: Preclinical evaluation of a recombinant adeno-associated virus vector expressing human alpha-1 antitrypsin made using a recombinant herpes simplex virus production method.

Authors: Chulay, Jeffrey D; Ye, Guo-Jie; Thomas, Darby L; Knop, David R; Benson, Janet M; Hutt, Julie A; Wang, Gensheng; Humphries, Margaret; Flotte, Terence R

Year: 2011

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2010.118

Paper Development of Versatile and Flexible Sf9 Packaging Cell Line-Dependent OneBac System for Large-Scale Recombinant Adeno-Associated Virus Production

Wu, Yang; Mei, Ting; Jiang, Liangyu et al. · 2019 · Human Gene Therapy Methods · DOI

Full title: Development of Versatile and Flexible Sf9 Packaging Cell Line-Dependent OneBac System for Large-Scale Recombinant Adeno-Associated Virus Production

Authors: Wu, Yang; Mei, Ting; Jiang, Liangyu; Han, Zengpeng; Dong, Ruping; Yang, Tian; Xu, Fuqiang

Year: 2019

Venue: Human Gene Therapy Methods

DOI: https://doi.org/10.1089/hgtb.2019.123

Paper rAAV Production and Titration at the Microscale for High-Throughput Screening.

Quan, David Nathan; Shiloach, Joseph · 2022 · Human gene therapy · DOI

Full title: rAAV Production and Titration at the Microscale for High-Throughput Screening.

Authors: Quan, David Nathan; Shiloach, Joseph

Year: 2022

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2021.080

Paper Detailed Protocol for the Novel and Scalable Viral Vector Upstream Process for AAV Gene Therapy Manufacturing.

Selvaraj, Nagarathinam; Wang, Chao-Kuei; Bowser, Brian et al. · 2021 · Human gene therapy · DOI

Full title: Detailed Protocol for the Novel and Scalable Viral Vector Upstream Process for AAV Gene Therapy Manufacturing.

Authors: Selvaraj, Nagarathinam; Wang, Chao-Kuei; Bowser, Brian; Broadt, Trevor; Shaban, Samir; Burns, Jenna; Saptharishi, Nirmala; Pechan, Peter; Golebiowski, Diane; Alimardanov, Asaf; Yang, Nora; Mitra, George; Vepachedu, Ramarao

Year: 2021

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2020.054

Paper Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale.

Lock, Martin; Alvira, Mauricio; Vandenberghe, Luk H et al. · 2010 · Human gene therapy · DOI

Full title: Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale.

Authors: Lock, Martin; Alvira, Mauricio; Vandenberghe, Luk H; Samanta, Arabinda; Toelen, Jaan; Debyser, Zeger; Wilson, James M

Year: 2010

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2010.055

Paper Restoration of cytoskeleton homeostasis after gigaxonin gene transfer for giant axonal neuropathy.

Mussche, Silke; Devreese, Bart; Nagabhushan Kalburgi, Sahana et al. · 2013 · Human gene therapy · DOI

Full title: Restoration of cytoskeleton homeostasis after gigaxonin gene transfer for giant axonal neuropathy.

Authors: Mussche, Silke; Devreese, Bart; Nagabhushan Kalburgi, Sahana; Bachaboina, Lavanya; Fox, Jonathan C; Shih, Hung-Jui; Van Coster, Rudy; Samulski, R Jude; Gray, Steven J

Year: 2013

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2012.107

Paper Protocol for Efficient Generation and Characterization of Adeno-Associated Viral Vectors.

Jungmann, Andreas; Leuchs, Barbara; Rommelaere, Jean et al. · 2017 · Human gene therapy methods · DOI

Full title: Protocol for Efficient Generation and Characterization of Adeno-Associated Viral Vectors.

Authors: Jungmann, Andreas; Leuchs, Barbara; Rommelaere, Jean; Katus, Hugo A; Müller, Oliver J

Year: 2017

Venue: Human gene therapy methods

DOI: https://doi.org/10.1089/hgtb.2017.192

Paper Benchmarking of Scale-X Bioreactor System in Lentiviral and Adenoviral Vector Production

Leinonen, Hanna; Lepola, Saana; Lipponen, Eevi M. et al. · 2020 · Human Gene Therapy · DOI

Full title: Benchmarking of Scale-X Bioreactor System in Lentiviral and Adenoviral Vector Production

Authors: Leinonen, Hanna; Lepola, Saana; Lipponen, Eevi M.; Heikura, Tommi; Koponen, Tiina; Parker, Nigel; Ylä‐Herttuala, Seppo; Lesch, Hanna P.

Year: 2020

Venue: Human Gene Therapy

DOI: https://doi.org/10.1089/hum.2019.247

Paper Modifiers of Adeno-Associated Virus-Mediated Gene Expression in Implication for Serotype-Universal Neutralizing Antibody Assay

Krotova, Karina; Aslanidi, George · 2020 · Human Gene Therapy · DOI

Full title: Modifiers of Adeno-Associated Virus-Mediated Gene Expression in Implication for Serotype-Universal Neutralizing Antibody Assay

Authors: Krotova, Karina; Aslanidi, George

Year: 2020

Venue: Human Gene Therapy

DOI: https://doi.org/10.1089/hum.2020.074

Paper Adeno-Associated Virus Vector Mobilization, Risk Versus Reality

Song, Liujiang; Samulski, R. Jude; Hirsch, Matthew L. · 2020 · Human Gene Therapy · DOI

Full title: Adeno-Associated Virus Vector Mobilization, Risk Versus Reality

Authors: Song, Liujiang; Samulski, R. Jude; Hirsch, Matthew L.

Year: 2020

Venue: Human Gene Therapy

DOI: https://doi.org/10.1089/hum.2020.118

Paper Deciphering Key Adenoviral Elements in the Production of Recombinant Adeno-Associated Virus Vectors.

Fernandes, Sofia; Guerra, Júlia; Ferreira, Mariana V et al. · 2025 · Human gene therapy · DOI

Full title: Deciphering Key Adenoviral Elements in the Production of Recombinant Adeno-Associated Virus Vectors.

Authors: Fernandes, Sofia; Guerra, Júlia; Ferreira, Mariana V; Coroadinha, Ana Sofia

Year: 2025

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2024.265

Paper Gene Transfer of ZMapp Antibodies Mediated by Recombinant Adeno-Associated Virus Protects Against Ebola Infections.

Robert, Marc-André; Nassoury, Nasha; Chahal, Parminder S et al. · 2018 · Human gene therapy · DOI

Full title: Gene Transfer of ZMapp Antibodies Mediated by Recombinant Adeno-Associated Virus Protects Against Ebola Infections.

Authors: Robert, Marc-André; Nassoury, Nasha; Chahal, Parminder S; Venne, Marie-Hélène; Racine, Trina; Qiu, Xiangguo; Kobinger, Gary; Kamen, Amine; Gilbert, Rénald; Gaillet, Bruno

Year: 2018

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2017.101

Paper Production of Recombinant Adeno-Associated Virus Through High-Cell-Density Transfection of HEK293 Cells Based on Fed-Perfusion Culture.

Deng, Zhe; Lv, Yan-Ling; Wang, Xin-Tao et al. · 2025 · Human gene therapy · DOI

Full title: Production of Recombinant Adeno-Associated Virus Through High-Cell-Density Transfection of HEK293 Cells Based on Fed-Perfusion Culture.

Authors: Deng, Zhe; Lv, Yan-Ling; Wang, Xin-Tao; Yuan, Long-Hui; Zhao, Kai; Du, Zeng-Min; Xiao, Xiao

Year: 2025

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2024.160

Paper Establishment of a novel cell line for the enhanced production of recombinant adeno-associated virus vectors for gene therapy.

Satkunanathan, Stifani; Wheeler, Jun; Thorpe, Robin et al. · 2014 · Human gene therapy · DOI

Full title: Establishment of a novel cell line for the enhanced production of recombinant adeno-associated virus vectors for gene therapy.

Authors: Satkunanathan, Stifani; Wheeler, Jun; Thorpe, Robin; Zhao, Yuan

Year: 2014

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2014.041

Paper British Society for Gene and Cell Therapy Annual Conference Wednesday 19th June – Friday 21st June 2019 University of Sheffield, Sheffield, UK www.bsgct.org

RV, Bell,; TAJ, McKinnon,; EWFW, Alton, et al. · 2019 · Human Gene Therapy · DOI

Full title: British Society for Gene and Cell Therapy Annual Conference Wednesday 19th June – Friday 21st June 2019 University of Sheffield, Sheffield, UK www.bsgct.org

Authors: RV, Bell,; TAJ, McKinnon,; EWFW, Alton,; U, Griesenbach,

Year: 2019

Venue: Human Gene Therapy

DOI: https://doi.org/10.1089/hum.2019.29087.abstracts

Paper Suppression of CNS APOE4 Expression by miRNAs Delivered by the S2 AAVrh.10 Capsid-Modified AAV Vector.

Karan, Kalpita R; Andrzejewski, Slawomir; Stiles, Katie M et al. · 2024 · Human gene therapy · DOI

Full title: Suppression of CNS APOE4 Expression by miRNAs Delivered by the S2 AAVrh.10 Capsid-Modified AAV Vector.

Authors: Karan, Kalpita R; Andrzejewski, Slawomir; Stiles, Katie M; Hackett, Neil R; Crystal, Ronald G

Year: 2024

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2024.112

Paper Progress and challenges in viral vector manufacturing

Loo, Johannes C.M. van der; Wright, J. Fraser · 2015 · Human Molecular Genetics · DOI

Full title: Progress and challenges in viral vector manufacturing

Authors: Loo, Johannes C.M. van der; Wright, J. Fraser

Year: 2015

Venue: Human Molecular Genetics

DOI: https://doi.org/10.1093/hmg/ddv451

Paper Neuro293: A REST-knockout HEK-293 cell line enables the expression of neuron-restricted genes for the high-throughput testing of human neurobiology and the biochemistry of neuronal proteins.

Moses, Joshua T; Shah, Fahad B; McVay, Nicholas M et al. · 2025 · Biology methods & protocols · DOI

Full title: Neuro293: A REST-knockout HEK-293 cell line enables the expression of neuron-restricted genes for the high-throughput testing of human neurobiology and the biochemistry of neuronal proteins.

Authors: Moses, Joshua T; Shah, Fahad B; McVay, Nicholas M; Capes, Dylan E; Bosse-Joseph, Christopher C; Salazar, Jocelyn; Slone, Victoria K; Eberth, John E; Satin, Jonathan; Stewart, Andrew N

Year: 2025

Venue: Biology methods & protocols

DOI: https://doi.org/10.1093/biomethods/bpaf036

Paper Significant Differences in Capsid Properties and Potency Between Adeno-Associated Virus Vectors Produced in Sf9 and HEK293 Cells.

Giles, April; Lock, Martin; Chen, Shu-Jen et al. · 2023 · Human gene therapy · DOI

Full title: Significant Differences in Capsid Properties and Potency Between Adeno-Associated Virus Vectors Produced in Sf9 and HEK293 Cells.

Authors: Giles, April; Lock, Martin; Chen, Shu-Jen; Turner, Kevin; Wesolowski, Gregg; Prongay, Andrew; Petkov, Boris N; Olagbegi, Kanyin; Yan, Hanying; Wilson, James M

Year: 2023

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2022.116

Paper Small interfering RNA-mediated knockdown of chicken interferon-γ expression.

Haq, Kamran; Wootton, Sarah K; Barjesteh, Neda et al. · 2013 · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · DOI

Full title: Small interfering RNA-mediated knockdown of chicken interferon-γ expression.

Authors: Haq, Kamran; Wootton, Sarah K; Barjesteh, Neda; St Paul, Michael; Golovan, Serguei; Bendall, Andrew J; Sharif, Shayan

Year: 2013

Venue: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

DOI: https://doi.org/10.1089/jir.2012.0141

Paper Human and Insect Cell-Produced Recombinant Adeno-Associated Viruses Show Differences in Genome Heterogeneity.

Tran, Ngoc Tam; Lecomte, Emilie; Saleun, Sylvie et al. · 2022 · Human gene therapy · DOI

Full title: Human and Insect Cell-Produced Recombinant Adeno-Associated Viruses Show Differences in Genome Heterogeneity.

Authors: Tran, Ngoc Tam; Lecomte, Emilie; Saleun, Sylvie; Namkung, Suk; Robin, Cécile; Weber, Kristina; Devine, Eric; Blouin, Veronique; Adjali, Oumeya; Ayuso, Eduard; Gao, Guangping; Penaud-Budloo, Magalie; Tai, Phillip W L

Year: 2022

Venue: Human gene therapy

DOI: https://doi.org/10.1089/hum.2022.050

Paper Magnetic resonance imaging of infarct-induced canonical wingless/integrated (Wnt)/β-catenin/T-cell factor pathway activation, in vivo.

Matteucci, Marco; Casieri, Valentina; Gabisonia, Khatia et al. · 2016 · Cardiovascular research · DOI

Full title: Magnetic resonance imaging of infarct-induced canonical wingless/integrated (Wnt)/β-catenin/T-cell factor pathway activation, in vivo.

Authors: Matteucci, Marco; Casieri, Valentina; Gabisonia, Khatia; Aquaro, Giovanni Donato; Agostini, Silvia; Pollio, Giuseppe; Diamanti, Daniela; Rossi, Marco; Travagli, Massimiliano; Porcari, Valentina; Recchia, Fabio A; Lionetti, Vincenzo

Year: 2016

Venue: Cardiovascular research

DOI: https://doi.org/10.1093/cvr/cvw214

Paper A concept of eliminating nonhomologous recombination for scalable and safe AAV vector generation for human gene therapy.

Dong, Biao; Moore, Andrea R; Dai, Jihong et al. · 2013 · Nucleic acids research · DOI

Full title: A concept of eliminating nonhomologous recombination for scalable and safe AAV vector generation for human gene therapy.

Authors: Dong, Biao; Moore, Andrea R; Dai, Jihong; Roberts, Sean; Chu, Kirk; Kapranov, Philipp; Moss, Bernard; Xiao, Weidong

Year: 2013

Venue: Nucleic acids research

DOI: https://doi.org/10.1093/nar/gkt404

Paper Adeno-Associated Virus Monoinfection Induces a DNA Damage Response and DNA Repair That Contributes to Viral DNA Replication.

Ning, Kang; Kuz, Cagla Aksu; Cheng, Fang et al. · 2023 · mBio · DOI

Full title: Adeno-Associated Virus Monoinfection Induces a DNA Damage Response and DNA Repair That Contributes to Viral DNA Replication.

Authors: Ning, Kang; Kuz, Cagla Aksu; Cheng, Fang; Feng, Zehua; Yan, Ziying; Qiu, Jianming

Year: 2023

Venue: mBio

DOI: https://doi.org/10.1128/mbio.03528-22

Paper Production of Recombinant Adeno-Associated Viruses (rAAVs) by Transient Transfection.

Su, Qin; Sena-Esteves, Miguel; Gao, Guangping · 2020 · Cold Spring Harbor protocols · DOI

Full title: Production of Recombinant Adeno-Associated Viruses (rAAVs) by Transient Transfection.

Authors: Su, Qin; Sena-Esteves, Miguel; Gao, Guangping

Year: 2020

Venue: Cold Spring Harbor protocols

DOI: https://doi.org/10.1101/pdb.prot095596

Paper Human Bocavirus 1 Is a Novel Helper for Adeno-associated Virus Replication.

Wang, Zekun; Deng, Xuefeng; Zou, Wei et al. · 2017 · Journal of virology · DOI

Full title: Human Bocavirus 1 Is a Novel Helper for Adeno-associated Virus Replication.

Authors: Wang, Zekun; Deng, Xuefeng; Zou, Wei; Engelhardt, John F; Yan, Ziying; Qiu, Jianming

Year: 2017

Venue: Journal of virology

DOI: https://doi.org/10.1128/JVI.00710-17

Paper Regulation of Blood Pressure by Targeting CaV1.2-Galectin-1 Protein Interaction.

Hu, Zhenyu; Li, Guang; Wang, Jiong-Wei et al. · 2018 · Circulation · DOI

Full title: Regulation of Blood Pressure by Targeting CaV1.2-Galectin-1 Protein Interaction.

Authors: Hu, Zhenyu; Li, Guang; Wang, Jiong-Wei; Chong, Suet Yen; Yu, Dejie; Wang, Xiaoyuan; Soon, Jia Lin; Liang, Mui Cheng; Wong, Yuk Peng; Huang, Na; Colecraft, Henry M; Liao, Ping; Soong, Tuck Wah

Year: 2018

Venue: Circulation

DOI: https://doi.org/10.1161/CIRCULATIONAHA.117.031231

Paper The HPV16 E1 Carboxyl Domain Provides a Helper Function for Adeno-Associated Virus Replication.

Cao, Maohua; Bandyopadhyay, Sarmistha; Zhu, Hongqing et al. · 2018 · Intervirology · DOI

Full title: The HPV16 E1 Carboxyl Domain Provides a Helper Function for Adeno-Associated Virus Replication.

Authors: Cao, Maohua; Bandyopadhyay, Sarmistha; Zhu, Hongqing; You, Hong; Hermonat, Paul L

Year: 2018

Venue: Intervirology

DOI: https://doi.org/10.1159/000495137

Paper Improved Genome Packaging Efficiency of Adeno-associated Virus Vectors Using Rep Hybrids.

Mietzsch, Mario; Eddington, Courtnee; Jose, Ariana et al. · 2021 · Journal of virology · DOI

Full title: Improved Genome Packaging Efficiency of Adeno-associated Virus Vectors Using Rep Hybrids.

Authors: Mietzsch, Mario; Eddington, Courtnee; Jose, Ariana; Hsi, Jane; Chipman, Paul; Henley, Tom; Choudhry, Modassir; McKenna, Robert; Agbandje-McKenna, Mavis

Year: 2021

Venue: Journal of virology

DOI: https://doi.org/10.1128/JVI.00773-21

Paper Viral gene transfer to developing mouse salivary glands.

Hsu, J C; Di Pasquale, G; Harunaga, J S et al. · 2012 · Journal of dental research · DOI

Full title: Viral gene transfer to developing mouse salivary glands.

Authors: Hsu, J C; Di Pasquale, G; Harunaga, J S; Onodera, T; Hoffman, M P; Chiorini, J A; Yamada, K M

Year: 2012

Venue: Journal of dental research

DOI: https://doi.org/10.1177/0022034511429346

Paper [A recombinant adeno-associated virus expressing secretory TGF-β type Ⅱ receptor inhibits triple-negative murine breast cancer 4T1 cell proliferation and lung metastasis in mice].

Cui, Z; Ma, C; Wang, Q et al. · 2024 · Nan fang yi ke da xue xue bao = Journal of Southern Medical University · DOI

Full title: [A recombinant adeno-associated virus expressing secretory TGF-β type Ⅱ receptor inhibits triple-negative murine breast cancer 4T1 cell proliferation and lung metastasis in mice].

Authors: Cui, Z; Ma, C; Wang, Q; Chen, J; Yan, Z; Yang, J; Lü, Y; Cao, C

Year: 2024

Venue: Nan fang yi ke da xue xue bao = Journal of Southern Medical University

DOI: https://doi.org/10.12122/j.issn.1673-4254.2024.05.03

Paper Can novel bioreactors improve the cost of goods of viral vectors?

Stamatis, Christos; Chatel, Alex; Farid, Suzanne S. · 2023 · Cell and Gene Therapy Insights · DOI

Full title: Can novel bioreactors improve the cost of goods of viral vectors?

Authors: Stamatis, Christos; Chatel, Alex; Farid, Suzanne S.

Year: 2023

Venue: Cell and Gene Therapy Insights

DOI: https://doi.org/10.18609/cgti.2023.087

Paper Optimized production of high-titer recombinant adeno-associated virus in roller bottles.

Liu, Y L; Wagner, K; Robinson, N et al. · 2003 · BioTechniques · DOI

Full title: Optimized production of high-titer recombinant adeno-associated virus in roller bottles.

Authors: Liu, Y L; Wagner, K; Robinson, N; Sabatino, D; Margaritis, P; Xiao, W; Herzog, R W

Year: 2003

Venue: BioTechniques

DOI: https://doi.org/10.2144/03341dd07

Paper Magnetic Field-Assisted Gene Delivery: Achievements and Therapeutic Potential

Schwerdt, José I.; Goya, Gerardo F.; Calatayud, M. Pilar et al. · 2012 · Current Gene Therapy · DOI

Full title: Magnetic Field-Assisted Gene Delivery: Achievements and Therapeutic Potential

Authors: Schwerdt, José I.; Goya, Gerardo F.; Calatayud, M. Pilar; Hereñú, Claudia Beatriz; Reggiani, Paula C.; Goya, Rodolfo G.

Year: 2012

Venue: Current Gene Therapy

DOI: https://doi.org/10.2174/156652312800099616

Paper Factors affecting recombinant Adeno-Associated Virus titers during triple-plasmid transient transfection in HEK-293 cells

Pistek, Martina; Andorfer, Peter; Grabherr, Reingard et al. · 2024 · Research Square (Research Square) · DOI

Full title: Factors affecting recombinant Adeno-Associated Virus titers during triple-plasmid transient transfection in HEK-293 cells

Authors: Pistek, Martina; Andorfer, Peter; Grabherr, Reingard; Kraus, Barbara; Bort, Juan A. Hernández

Year: 2024

Venue: Research Square (Research Square)

DOI: https://doi.org/10.21203/rs.3.rs-4252754/v1

Paper Characterizing the Biopotency of Truncated Transgene Variants in rAAV8 viral vectors: Essential Considerations for Gene Therapy Applications

Fiedler, Christian; Lengler, Johannes; Gruber, Bernadette et al. · 2024 · Research Square (Research Square) · DOI

Full title: Characterizing the Biopotency of Truncated Transgene Variants in rAAV8 viral vectors: Essential Considerations for Gene Therapy Applications

Authors: Fiedler, Christian; Lengler, Johannes; Gruber, Bernadette; Scheindel, Marcus; Büngener, Carsten; Mittergradnegger, Dominik; Bendik, Marian; Kraus, Barbara; Bort, Juan A. Hernández

Year: 2024

Venue: Research Square (Research Square)

DOI: https://doi.org/10.21203/rs.3.rs-4043201/v1

Paper Delivery of dCas9 CRISPR System Into the Hard Transfection Cells by Magnetofection Approach

Ghanbarlou, Mahdi Mohammadi; Abdoli, Shahriyar; Bamehr, Hadi et al. · 2021 · Research Square (Research Square) · DOI

Full title: Delivery of dCas9 CRISPR System Into the Hard Transfection Cells by Magnetofection Approach

Authors: Ghanbarlou, Mahdi Mohammadi; Abdoli, Shahriyar; Bamehr, Hadi; Qazizadeh, Leila; Omid, Hamed; Iranpour, Hamidreza; Shahsavarani, Hosein; Karimipour, Morteza; Shokrgozar, Mohammad Ali

Year: 2021

Venue: Research Square (Research Square)

DOI: https://doi.org/10.21203/rs.3.rs-999842/v1

Paper ONLY A SMALL FRACTION OF CELLS PRODUCE ASSEMBLED CAPSIDS DURING TRANSFECTION-BASED MANUFACTURING OF ADENO-ASSOCIATED VIRUS VECTORS

Dash, Shantoshini; Sharon, David; Mullick, Alaka et al. · 2021 · DOI

Full title: ONLY A SMALL FRACTION OF CELLS PRODUCE ASSEMBLED CAPSIDS DURING TRANSFECTION-BASED MANUFACTURING OF ADENO-ASSOCIATED VIRUS VECTORS

Authors: Dash, Shantoshini; Sharon, David; Mullick, Alaka; Kamen, Amine

Year: 2021

DOI: https://doi.org/10.22541/au.163687913.34133715/v1

Paper Advancements in Insect-Cell Baculovirus Expression Vector Platform for Production of Recombinant Adeno-Associated Virus-Based Gene Delivery Vectors

Joshi, Pranav R.H.; Sanchez, Alina Venereo; Chahal, Parminder S. et al. · 2020 · Authorea · DOI

Full title: Advancements in Insect-Cell Baculovirus Expression Vector Platform for Production of Recombinant Adeno-Associated Virus-Based Gene Delivery Vectors

Authors: Joshi, Pranav R.H.; Sanchez, Alina Venereo; Chahal, Parminder S.; Kamen, Amine

Year: 2020

Venue: Authorea

DOI: https://doi.org/10.22541/au.158750380.04327747

Paper Development of carbamate modified PEI for delivery of a granzyme B inhibitor gene to protect against cytotoxic lymphocyte killing

Cheng, Wei · 2013 · Spiral (Imperial College London) · DOI

Full title: Development of carbamate modified PEI for delivery of a granzyme B inhibitor gene to protect against cytotoxic lymphocyte killing

Authors: Cheng, Wei

Year: 2013

Venue: Spiral (Imperial College London)

DOI: https://doi.org/10.25560/23983

Paper Increased recombinant AAV production by HEK293 cells using small molecule chemical additives

Scarrott, Joseph M.; Johari, Yusuf B.; Pohle, Thilo H. et al. · 2022 · DOI

Full title: Increased recombinant AAV production by HEK293 cells using small molecule chemical additives

Authors: Scarrott, Joseph M.; Johari, Yusuf B.; Pohle, Thilo H.; Liu, Ping; Mayer, Ayda; James, David A.

Year: 2022

DOI: https://doi.org/10.22541/au.166051625.50657820/v1

Paper Engineering pseudovirions for large-scale targeted gene transfer and recombinant adeno-associated virus production

Asavarut, Paladd · 2018 · Spiral (Imperial College London) · DOI

Full title: Engineering pseudovirions for large-scale targeted gene transfer and recombinant adeno-associated virus production

Authors: Asavarut, Paladd

Year: 2018

Venue: Spiral (Imperial College London)

DOI: https://doi.org/10.25560/86379

Paper Construction and optimization of novel recombinant Adeno-Associated Virus rAAV2/5 for targeting microglia to regulate immune responses during neuroinflammation

Belhoul‐Fakir, Hanane · 2014 · DOI

Full title: Construction and optimization of novel recombinant Adeno-Associated Virus rAAV2/5 for targeting microglia to regulate immune responses during neuroinflammation

Authors: Belhoul‐Fakir, Hanane

Year: 2014

DOI: https://doi.org/10.26686/wgtn.17008231.v1

Paper High-cell-density production of adeno-associated viral vector serotype 6 by triple transfection in suspension HEK293 cell cultures

Moço, Pablo Diego; Xu, Xingge; Kamen, Amine · 2023 · DOI

Full title: High-cell-density production of adeno-associated viral vector serotype 6 by triple transfection in suspension HEK293 cell cultures

Authors: Moço, Pablo Diego; Xu, Xingge; Kamen, Amine

Year: 2023

DOI: https://doi.org/10.22541/au.167535214.41739207/v1

Paper Construction and optimization of novel recombinant Adeno-Associated Virus rAAV2/5 for targeting microglia to regulate immune responses during neuroinflammation

Belhoul‐Fakir, Hanane · 2014 · DOI

Full title: Construction and optimization of novel recombinant Adeno-Associated Virus rAAV2/5 for targeting microglia to regulate immune responses during neuroinflammation

Authors: Belhoul‐Fakir, Hanane

Year: 2014

DOI: https://doi.org/10.26686/wgtn.17008231.v1

Paper Downregulation of α-Synuclein Protein Levels by an Intracellular Single-Chain Antibody.

Chen, Yun-Hsiang; Yu, Seong-Jin; Wu, Kuo-Jen et al. · 2020 · Journal of Parkinson's disease · DOI

Full title: Downregulation of α-Synuclein Protein Levels by an Intracellular Single-Chain Antibody.

Authors: Chen, Yun-Hsiang; Yu, Seong-Jin; Wu, Kuo-Jen; Wang, Yu-Syuan; Tsai, Ho-Min; Liao, Li-Wen; Chen, Shuchun; Hsieh, Wei; Chen, Hsi; Hsu, Shu-Ching; Chen, Mao-Liang; Hoffer, Barry J; Wang, Yun

Year: 2020

Venue: Journal of Parkinson's disease

DOI: https://doi.org/10.3233/JPD-191787

Paper Manufacturing Cell and Gene Therapies: Challenges in Clinical Translation

Lee, Na Kyung; Chang, Jong Wook · 2024 · Annals of Laboratory Medicine · DOI

Full title: Manufacturing Cell and Gene Therapies: Challenges in Clinical Translation

Authors: Lee, Na Kyung; Chang, Jong Wook

Year: 2024

Venue: Annals of Laboratory Medicine

DOI: https://doi.org/10.3343/alm.2023.0382

Paper Process Improvement of Adeno-Associated Virus Production

Guan, Jia-Shiung; Chen, Kai; Si, Yingnan et al. · 2022 · Frontiers in Chemical Engineering · DOI

Full title: Process Improvement of Adeno-Associated Virus Production

Authors: Guan, Jia-Shiung; Chen, Kai; Si, Yingnan; Kim, Tae Hyun; Zhou, Zhuoxin “Zora”; Kim, Seulhee; Zhou, Lufang; Liu, Xiaoguang

Year: 2022

Venue: Frontiers in Chemical Engineering

DOI: https://doi.org/10.3389/fceng.2022.830421

Paper rAAV Manufacturing: The Challenges of Soft Sensing during Upstream Processing

Iglesias, Cristovão Freitas; Ristovski, Miliça; Bolić, Miodrag et al. · 2023 · Bioengineering · DOI

Full title: rAAV Manufacturing: The Challenges of Soft Sensing during Upstream Processing

Authors: Iglesias, Cristovão Freitas; Ristovski, Miliça; Bolić, Miodrag; Čuperlović‐Culf, Miroslava

Year: 2023

Venue: Bioengineering

DOI: https://doi.org/10.3390/bioengineering10020229

Paper Establishment of a Recombinant AAV2/HBoV1 Vector Production System in Insect Cells.

Deng, Xuefeng; Zou, Wei; Yan, Ziying et al. · 2020 · Genes · DOI

Full title: Establishment of a Recombinant AAV2/HBoV1 Vector Production System in Insect Cells.

Authors: Deng, Xuefeng; Zou, Wei; Yan, Ziying; Qiu, Jianming

Year: 2020

Venue: Genes

DOI: https://doi.org/10.3390/genes11040439

Paper Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays

Buck, Thilo M.; Wijnholds, Jan · 2020 · International Journal of Molecular Sciences · DOI

Full title: Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays

Authors: Buck, Thilo M.; Wijnholds, Jan

Year: 2020

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms21124197

Paper Affecting HEK293 Cell Growth and Production Performance by Modifying the Expression of Specific Genes

Abaandou, Laura; Quan, David N.; Shiloach, Joseph · 2021 · Cells · DOI

Full title: Affecting HEK293 Cell Growth and Production Performance by Modifying the Expression of Specific Genes

Authors: Abaandou, Laura; Quan, David N.; Shiloach, Joseph

Year: 2021

Venue: Cells

DOI: https://doi.org/10.3390/cells10071667

Paper A Direct Comparison of rAAV5 Variants Derived from the Baculovirus Expression System Using LC-MS Workflows Demonstrates Key Differences in Overall Production Yield, Product Quality and Vector Efficiency

Guapo, Felipe; Donohue, Nicholas; Strasser, Lisa et al. · 2024 · International Journal of Molecular Sciences · DOI

Full title: A Direct Comparison of rAAV5 Variants Derived from the Baculovirus Expression System Using LC-MS Workflows Demonstrates Key Differences in Overall Production Yield, Product Quality and Vector Efficiency

Authors: Guapo, Felipe; Donohue, Nicholas; Strasser, Lisa; Boi, Stefano; Füssl, Florian; Rainbow-Fletcher, Alana; Getty, Paul M.; Anderson, Ian; Barron, Niall; Bones, Jonathan

Year: 2024

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms25052785

Paper Synthetic Approaches for Nucleic Acid Delivery: Choosing the Right Carriers

Ni, Rong; Feng, Ruilu; Chau, Ying · 2019 · Life · DOI

Full title: Synthetic Approaches for Nucleic Acid Delivery: Choosing the Right Carriers

Authors: Ni, Rong; Feng, Ruilu; Chau, Ying

Year: 2019

Venue: Life

DOI: https://doi.org/10.3390/life9030059

Paper Purification of Adeno-Associated Virus (AAV) Serotype 2 from Spodoptera frugiperda (Sf9) Lysate by Chromatographic Nonwoven Membranes

Fan, Jinxin; Barbieri, Eduardo; Shastry, Shriarjun et al. · 2022 · Membranes · DOI

Full title: Purification of Adeno-Associated Virus (AAV) Serotype 2 from Spodoptera frugiperda (Sf9) Lysate by Chromatographic Nonwoven Membranes

Authors: Fan, Jinxin; Barbieri, Eduardo; Shastry, Shriarjun; Menegatti, Stefano; Boi, Cristiana; Carbonell, Ruben G.

Year: 2022

Venue: Membranes

DOI: https://doi.org/10.3390/membranes12100944

Paper Proteomic Landscape of Adeno-Associated Virus (AAV)-Producing HEK293 Cells.

Strasser, Lisa; Boi, Stefano; Guapo, Felipe et al. · 2021 · International journal of molecular sciences · DOI

Full title: Proteomic Landscape of Adeno-Associated Virus (AAV)-Producing HEK293 Cells.

Authors: Strasser, Lisa; Boi, Stefano; Guapo, Felipe; Donohue, Nicholas; Barron, Niall; Rainbow-Fletcher, Alana; Bones, Jonathan

Year: 2021

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms222111499

Paper Development of Stable Packaging and Producer Cell Lines for the Production of AAV Vectors.

Merten, Otto-Wilhelm · 2024 · Microorganisms · DOI

Full title: Development of Stable Packaging and Producer Cell Lines for the Production of AAV Vectors.

Authors: Merten, Otto-Wilhelm

Year: 2024

Venue: Microorganisms

DOI: https://doi.org/10.3390/microorganisms12020384

Paper Nuclear Fraction Proteome Analyses During rAAV Production of AAV2-Plasmid-Transfected HEK-293 Cells.

Golm, Susanne K; Hoffrogge, Raimund; Müller, Kristian M · 2025 · International journal of molecular sciences · DOI

Full title: Nuclear Fraction Proteome Analyses During rAAV Production of AAV2-Plasmid-Transfected HEK-293 Cells.

Authors: Golm, Susanne K; Hoffrogge, Raimund; Müller, Kristian M

Year: 2025

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms26136315

Paper Biodegradable Polymers for Gene Delivery

Thomas, Thresia; Tajmir‐Riahi, Heidar‐Ali; Pillai, C. K. S. · 2019 · Molecules · DOI

Full title: Biodegradable Polymers for Gene Delivery

Authors: Thomas, Thresia; Tajmir‐Riahi, Heidar‐Ali; Pillai, C. K. S.

Year: 2019

Venue: Molecules

DOI: https://doi.org/10.3390/molecules24203744

Paper Bioengineered Hybrid Rep 2/6 Gene Improves Encapsulation of a Single-Stranded Expression Cassette into AAV6 Vectors

Tejero, Marcos; Duzenli, Ozgun F.; Caine, Colin et al. · 2023 · Genes · DOI

Full title: Bioengineered Hybrid Rep 2/6 Gene Improves Encapsulation of a Single-Stranded Expression Cassette into AAV6 Vectors

Authors: Tejero, Marcos; Duzenli, Ozgun F.; Caine, Colin; Kuoch, Hisae; Aslanidi, George

Year: 2023

Venue: Genes

DOI: https://doi.org/10.3390/genes14101866

Paper Dielectric Spectroscopy to Improve the Production of rAAV Used in Gene Therapy

Pais, Daniel A. M.; Brown, Chris W.; Neuman, Anastasia et al. · 2020 · Processes · DOI

Full title: Dielectric Spectroscopy to Improve the Production of rAAV Used in Gene Therapy

Authors: Pais, Daniel A. M.; Brown, Chris W.; Neuman, Anastasia; Mathur, Krishanu; Isidro, Inês A.; Alves, Paula M.; Slade, Peter G.

Year: 2020

Venue: Processes

DOI: https://doi.org/10.3390/pr8111456

Paper Production of an Oncolytic Adeno-Associated Virus Containing the Pro-Apoptotic TRAIL Gene Can Be Improved by shRNA Interference

Donohue, Nicholas; Li, Simeng; Boi, Stefano et al. · 2025 · International Journal of Molecular Sciences · DOI

Full title: Production of an Oncolytic Adeno-Associated Virus Containing the Pro-Apoptotic TRAIL Gene Can Be Improved by shRNA Interference

Authors: Donohue, Nicholas; Li, Simeng; Boi, Stefano; Rainbow-Fletcher, Alana; Barron, Niall

Year: 2025

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms26020567

Paper Engineered AAV2.7m8 Serotype Shows Significantly Higher Transduction Efficiency of ARPE-19 and HEK293 Cell Lines Compared to AAV5, AAV8 and AAV9 Serotypes

Gurtsieva, Dzerassa; Minskaia, Ekaterina; Zhuravleva, Sofia et al. · 2024 · Pharmaceutics · DOI

Full title: Engineered AAV2.7m8 Serotype Shows Significantly Higher Transduction Efficiency of ARPE-19 and HEK293 Cell Lines Compared to AAV5, AAV8 and AAV9 Serotypes

Authors: Gurtsieva, Dzerassa; Minskaia, Ekaterina; Zhuravleva, Sofia; Субчева, Е. Н.; Sakhibgaraeva, Elena; Brovin, Andrew; Tumaev, Artem; Karabelsky, Alexander

Year: 2024

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics16010138

Paper Chitosan for Gene Delivery and Orthopedic Tissue Engineering Applications

Raftery, Rosanne M.; O’Brien, Fergal J.; Cryan, Sally‐Ann · 2013 · Molecules · DOI

Full title: Chitosan for Gene Delivery and Orthopedic Tissue Engineering Applications

Authors: Raftery, Rosanne M.; O’Brien, Fergal J.; Cryan, Sally‐Ann

Year: 2013

Venue: Molecules

DOI: https://doi.org/10.3390/molecules18055611

Paper Large-Scale Production of Lentiviral Vectors: Current Perspectives and Challenges

Martínez-Molina, Eduardo; Chocarro‐Wrona, Carlos; Martínez‐Moreno, Daniel et al. · 2020 · Pharmaceutics · DOI

Full title: Large-Scale Production of Lentiviral Vectors: Current Perspectives and Challenges

Authors: Martínez-Molina, Eduardo; Chocarro‐Wrona, Carlos; Martínez‐Moreno, Daniel; Marchal, Juan Antonio; Boulaiz, Houría

Year: 2020

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics12111051

Paper [Optimized AAV package and experimental application of recombinant AAV8/hFⅧ for gene therapy on hemophilia A mice].

Mao, J H; Shen, Y; Wang, Q et al. · 2020 · Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · DOI

Full title: [Optimized AAV package and experimental application of recombinant AAV8/hFⅧ for gene therapy on hemophilia A mice].

Authors: Mao, J H; Shen, Y; Wang, Q; Wang, Y; Ruan, Z; Xi, X D

Year: 2020

Venue: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

DOI: https://doi.org/10.3760/cma.j.issn.0253-2727.2020.01.007

Paper In-Depth Comparison of Adeno-Associated Virus Containing Fractions after CsCl Ultracentrifugation Gradient Separation

Janc, M.; Zevnik, Kaja; Dolinar, Ana et al. · 2024 · Viruses · DOI

Full title: In-Depth Comparison of Adeno-Associated Virus Containing Fractions after CsCl Ultracentrifugation Gradient Separation

Authors: Janc, M.; Zevnik, Kaja; Dolinar, Ana; Jakomin, Tjaša; Štalekar, Maja; Bačnik, Katarina; Kutnjak, Denis; Žnidarič, Magda Tušek; Zentilin, Lorena; Fedorov, D. L.; Dobnik, David

Year: 2024

Venue: Viruses

DOI: https://doi.org/10.3390/v16081235

Paper Bacteriophage Mediates Efficient Gene Transfer in Combination with Conventional Transfection Reagents

Donnelly, Amanda; Yata, Teerapong; Bentayebi, Kaoutar et al. · 2015 · Viruses · DOI

Full title: Bacteriophage Mediates Efficient Gene Transfer in Combination with Conventional Transfection Reagents

Authors: Donnelly, Amanda; Yata, Teerapong; Bentayebi, Kaoutar; Suwan, Keittisak; Hajitou, Amin

Year: 2015

Venue: Viruses

DOI: https://doi.org/10.3390/v7122951

Paper AAV Vectors Pseudotyped with Capsids from Porcine and Bovine Species Mediate In Vitro and In Vivo Gene Delivery

Yu, Darrick L.; Lieshout, Laura P. van; Stevens, Brenna A. Y. et al. · 2023 · Viruses · DOI

Full title: AAV Vectors Pseudotyped with Capsids from Porcine and Bovine Species Mediate In Vitro and In Vivo Gene Delivery

Authors: Yu, Darrick L.; Lieshout, Laura P. van; Stevens, Brenna A. Y.; Near, Kelsie J.; Stodola, Jenny K.; Stinson, Kevin J.; Slavić, Ðurđa; Wootton, Sarah K.

Year: 2023

Venue: Viruses

DOI: https://doi.org/10.3390/v16010057

Paper Faculty Opinions recommendation of Adeno-associated virus vector as a platform for gene therapy delivery.

Fehlings, Michael G. · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · DOI

Full title: Faculty Opinions recommendation of Adeno-associated virus vector as a platform for gene therapy delivery.

Authors: Fehlings, Michael G.

Year: 2020

Venue: Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI: https://doi.org/10.3410/f.734958350.793573257

Paper Production and titering of recombinant adeno-associated viral vectors.

McClure, Christina; Cole, Katy L H; Wulff, Peer et al. · 2011 · Journal of visualized experiments : JoVE · DOI

Full title: Production and titering of recombinant adeno-associated viral vectors.

Authors: McClure, Christina; Cole, Katy L H; Wulff, Peer; Klugmann, Matthias; Murray, Andrew J

Year: 2011

Venue: Journal of visualized experiments : JoVE

DOI: https://doi.org/10.3791/3348

Paper Lentiviral Vector Bioprocessing

Perry, Christopher; Rayat, Andrea · 2021 · Viruses · DOI

Full title: Lentiviral Vector Bioprocessing

Authors: Perry, Christopher; Rayat, Andrea

Year: 2021

Venue: Viruses

DOI: https://doi.org/10.3390/v13020268

Paper Using Adeno-associated Virus as a Tool to Study Retinal Barriers in Disease.

Vacca, Ophélie; El Mathari, Brahim; Darche, Marie et al. · 2015 · Journal of visualized experiments : JoVE · DOI

Full title: Using Adeno-associated Virus as a Tool to Study Retinal Barriers in Disease.

Authors: Vacca, Ophélie; El Mathari, Brahim; Darche, Marie; Sahel, José-Alain; Rendon, Alvaro; Dalkara, Deniz

Year: 2015

Venue: Journal of visualized experiments : JoVE

DOI: https://doi.org/10.3791/52451

Paper Comprehensive Comparison of Baculoviral and Plasmid Gene Delivery in Mammalian Cells

Tóth, Mária; Reithofer, Manuel; Dutra, Gregory et al. · 2024 · Viruses · DOI

Full title: Comprehensive Comparison of Baculoviral and Plasmid Gene Delivery in Mammalian Cells

Authors: Tóth, Mária; Reithofer, Manuel; Dutra, Gregory; Aguilar, Patrícia Pereira; Dürauer, Astrid; Grabherr, Reingard

Year: 2024

Venue: Viruses

DOI: https://doi.org/10.3390/v16030426

Paper High-Level rAAV Vector Production by rAdV-Mediated Amplification of Small Amounts of Input Vector

Weger, Stefan · 2022 · Viruses · DOI

Full title: High-Level rAAV Vector Production by rAdV-Mediated Amplification of Small Amounts of Input Vector

Authors: Weger, Stefan

Year: 2022

Venue: Viruses

DOI: https://doi.org/10.3390/v15010064

Paper Production of High-Yield Adeno Associated Vector Batches Using HEK293 Suspension Cells.

Pietersz, Kimberly L; Nijhuis, Paul J H; Klunder, Matthijs H M et al. · 2024 · Journal of visualized experiments : JoVE · DOI

Full title: Production of High-Yield Adeno Associated Vector Batches Using HEK293 Suspension Cells.

Authors: Pietersz, Kimberly L; Nijhuis, Paul J H; Klunder, Matthijs H M; van den Herik, Joëlle; Hobo, Barbara; de Winter, Fred; Verhaagen, Joost

Year: 2024

Venue: Journal of visualized experiments : JoVE

DOI: https://doi.org/10.3791/66532

Paper Bioreducible polycationic gene vectors

Gao, Si · 2015 · DOI

Full title: Bioreducible polycationic gene vectors

Authors: Gao, Si

Year: 2015

DOI: https://doi.org/10.3990/1.9789036540407

Paper Characterization of Extracellular Vesicles Secreted in Lentiviral Producing HEK293SF Cell Cultures

Minh, Aline Do; Star, Alexandra T.; Stupak, Jacek et al. · 2021 · Viruses · DOI

Full title: Characterization of Extracellular Vesicles Secreted in Lentiviral Producing HEK293SF Cell Cultures

Authors: Minh, Aline Do; Star, Alexandra T.; Stupak, Jacek; Fulton, Kelly M.; Haqqani, Arsalan S.; Gélinas, Jean‐François; Li, Jianjun; Twine, Susan M.; Kamen, Amine

Year: 2021

Venue: Viruses

DOI: https://doi.org/10.3390/v13050797

Paper Production, Purification, and Quality Control for Adeno-associated Virus-based Vectors

Fripont, Shelly; Marneffe, Catherine; Marino, Marika et al. · 2019 · Journal of Visualized Experiments · DOI

Full title: Production, Purification, and Quality Control for Adeno-associated Virus-based Vectors

Authors: Fripont, Shelly; Marneffe, Catherine; Marino, Marika; Rincón, Melvin Y.; Holt, Matthew G.

Year: 2019

Venue: Journal of Visualized Experiments

DOI: https://doi.org/10.3791/58960

Paper JoVE Video Dataset

Benyamini, Brian; Esbin, Meagan N.; Whitney, Oscar N. et al. · 2023 · DOI

Full title: JoVE Video Dataset

Authors: Benyamini, Brian; Esbin, Meagan N.; Whitney, Oscar N.; Walther, Nike; Maurer, Anna C.

Year: 2023

DOI: https://doi.org/10.3791/65572-v

Paper Engineered genetic tools for directed gene regulation

Ferreira, Rafael Rinaldi · 2021 · DOI

Full title: Engineered genetic tools for directed gene regulation

Authors: Ferreira, Rafael Rinaldi

Year: 2021

DOI: https://doi.org/10.53846/goediss-8703

Paper Adeno-Associated Virus Production in Serum-Free Suspension Adapted HEK293 Cells for Gene Therapy.

Ijeomah, Brenda Ijeoma · 2019 · NCSU Libraries Repository (North Carolina State University Libraries)

Full title: Adeno-Associated Virus Production in Serum-Free Suspension Adapted HEK293 Cells for Gene Therapy.

Authors: Ijeomah, Brenda Ijeoma

Year: 2019

Venue: NCSU Libraries Repository (North Carolina State University Libraries)

Paper [Construction and expression of adeno-associated virus vectors of Smad 6 and Smad 7 genes in human renal tubule epithelial cells].

Huang, Yun-Jian; Zhao, Jing-Hong; Yang, Tang-Jun et al. · 2004 · Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

Full title: [Construction and expression of adeno-associated virus vectors of Smad 6 and Smad 7 genes in human renal tubule epithelial cells].

Authors: Huang, Yun-Jian; Zhao, Jing-Hong; Yang, Tang-Jun; Zhang, Jin-Hai; Cai, Wen-Qin

Year: 2004

Venue: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

Paper Development of a multiplexed RNAi-coupled sensor assay to study neuronal function on the large-scale

Herholt, Alexander · 2017 · DOI

Full title: Development of a multiplexed RNAi-coupled sensor assay to study neuronal function on the large-scale

Authors: Herholt, Alexander

Year: 2017

DOI: https://doi.org/10.53846/goediss-6199

Paper [Establishment and Application of a Model of Well-differentiated Porcine Airway Epithelial Cells in Vitro].

Zhang, Shaodan; Liu, Hongmei; Liu, Zhong et al. · 2015 · Bing du xue bao = Chinese journal of virology

Full title: [Establishment and Application of a Model of Well-differentiated Porcine Airway Epithelial Cells in Vitro].

Authors: Zhang, Shaodan; Liu, Hongmei; Liu, Zhong; Li, Wuping

Year: 2015

Venue: Bing du xue bao = Chinese journal of virology

Paper [Construction and identification of the recombination adeno-associated virus carrying murine FoxP3 gene].

Wang, Sheng-jun; Ma, Jie; Ma, Bin et al. · 2007 · Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

Full title: [Construction and identification of the recombination adeno-associated virus carrying murine FoxP3 gene].

Authors: Wang, Sheng-jun; Ma, Jie; Ma, Bin; Mao, Chao-ming; Tong, Jia; Yang, Min; Shao, Qi-xiang; Xu, Hua-xi

Year: 2007

Venue: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

Paper [Construction and identification of recombinant adeno-associated virus shuttle vector expressing nerve growth factor beta gene].

Li, Ruofei; Gao, Dalong; Dang, Xiaoqian et al. · 2012 · Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

Full title: [Construction and identification of recombinant adeno-associated virus shuttle vector expressing nerve growth factor beta gene].

Authors: Li, Ruofei; Gao, Dalong; Dang, Xiaoqian; Wang, Kunzheng; Yang, Leigang; Tu, Zhongmin

Year: 2012

Venue: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

Paper [Construction and expression of non-structural protein gene 3-4b of HCV 1b based on the adenoassociated virus vector].

Chen, Tian; Sun, Hai-Xia; Qin, Wei-Bin et al. · 2013 · Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology

Full title: [Construction and expression of non-structural protein gene 3-4b of HCV 1b based on the adenoassociated virus vector].

Authors: Chen, Tian; Sun, Hai-Xia; Qin, Wei-Bin; Zhu, Feng-Qin; Li, Xue-Ling; Cao, Hong; Xu, Qi-Huan; Li, Gang

Year: 2013

Venue: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology

Paper [Construction of adeno-associated virus vector containing human papilloma virus 16 E7 gene and its expression in eukaryotic cells].

Zhang, Juan; Lin, Zhong-qiu; Peng, Yong-pai et al. · 2005 · Zhonghua fu chan ke za zhi

Full title: [Construction of adeno-associated virus vector containing human papilloma virus 16 E7 gene and its expression in eukaryotic cells].

Authors: Zhang, Juan; Lin, Zhong-qiu; Peng, Yong-pai; Zhang, Bing-zhong; Zhou, Hui; Yang, Qing-yuan

Year: 2005

Venue: Zhonghua fu chan ke za zhi

Paper [Construction of an adenoassociated, viral derived, expression vector to correct the genetic defect in Morquio A disease].

Gutiérrez, Mónica A; García-Vallejo, Felipe; Tomatsu, Shunji et al. · 2008 · Biomedica : revista del Instituto Nacional de Salud

Full title: [Construction of an adenoassociated, viral derived, expression vector to correct the genetic defect in Morquio A disease].

Authors: Gutiérrez, Mónica A; García-Vallejo, Felipe; Tomatsu, Shunji; Cerón, Flavio; Alméciga-Díaz, Carlos J; Domínguez, Martha C; Barrera, Luis A

Year: 2008

Venue: Biomedica : revista del Instituto Nacional de Salud

Paper [A novel packaging system of recombinant AAV5/5 vector].

Dong, Xiaoyan; Tian, Wenhong; Yuan, Zhenhua et al. · 2010 · Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Full title: [A novel packaging system of recombinant AAV5/5 vector].

Authors: Dong, Xiaoyan; Tian, Wenhong; Yuan, Zhenhua; Tan, Shuping; Wu, Xiaobing

Year: 2010

Venue: Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Paper [Expression of human tumor necrosis factor receptor-Fc fusion protein and characterization of its biological activity].

Du, Zhiyan; Wang, Fang; Zhu, Jingying et al. · 2014 · Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

Full title: [Expression of human tumor necrosis factor receptor-Fc fusion protein and characterization of its biological activity].

Authors: Du, Zhiyan; Wang, Fang; Zhu, Jingying; Yu, Jiyun; Wang, Yu; Zhu, Xiaoming; Zhang, Wei

Year: 2014

Venue: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

Paper [Expression of TRAIL(114-281) mediated by adeno-associated virus and its tumoricidal activity].

Ma, Hong; Liu, Yan-Xin; Liu, Shi-Lian et al. · 2004 · Zhonghua yi xue za zhi

Full title: [Expression of TRAIL(114-281) mediated by adeno-associated virus and its tumoricidal activity].

Authors: Ma, Hong; Liu, Yan-Xin; Liu, Shi-Lian; Xu, Rui-An; Zheng, De-Xian

Year: 2004

Venue: Zhonghua yi xue za zhi

Paper Development of a Therapeutic CRISPR/Cas9 Platform for Duchenne Muscular Dystrophy

Young, Courtney S. · 2018 · eScholarship (California Digital Library)

Full title: Development of a Therapeutic CRISPR/Cas9 Platform for Duchenne Muscular Dystrophy

Authors: Young, Courtney S.

Year: 2018

Venue: eScholarship (California Digital Library)

Paper Engineering of the CMV promoter for controlled expression of recombinant genes in HEK293 cells

Johari, Yusuf B.; Scarrott, Joseph M.; Pohle, Thilo H. et al. · 2022 · Biotechnology Journal · DOI

Full title: Engineering of the CMV promoter for controlled expression of recombinant genes in HEK293 cells

Authors: Johari, Yusuf B.; Scarrott, Joseph M.; Pohle, Thilo H.; Liu, Ping; Mayer, Ayda; Brown, Adam; James, David C.

Year: 2022

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202200062

Paper [Expression and Regulatory Effect of miR-30b on Dynamin in Cochlear Hair Cells].

Li, Yang; Tang, Xiao-Lin; Yu, Fei et al. · 2018 · Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

Full title: [Expression and Regulatory Effect of miR-30b on Dynamin in Cochlear Hair Cells].

Authors: Li, Yang; Tang, Xiao-Lin; Yu, Fei; Li, Hua-Jun; Yuan, Wei

Year: 2018

Venue: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

Paper [Regulation of AAV-mediated glial cell-line derived neurotrophic factor expression by using improved Tet-on trans-activator].

Chen, Teng; Li, Xin-Gang; Wu, Cheng-Yuan et al. · 2005 · Zhonghua yi xue za zhi

Full title: [Regulation of AAV-mediated glial cell-line derived neurotrophic factor expression by using improved Tet-on trans-activator].

Authors: Chen, Teng; Li, Xin-Gang; Wu, Cheng-Yuan; Takashi, Okada; Keiya, Ozawa

Year: 2005

Venue: Zhonghua yi xue za zhi

Paper [Specific antitumor effect of adeno-associated virus vector carrying TRAIL gene under the control of hTERT promoter].

Qi, Rong; Cai, Ying; Li, Bing-Hua et al. · 2008 · Ai zheng = Aizheng = Chinese journal of cancer

Full title: [Specific antitumor effect of adeno-associated virus vector carrying TRAIL gene under the control of hTERT promoter].

Authors: Qi, Rong; Cai, Ying; Li, Bing-Hua; Lin, Zhi-Xin; Gu, Jin-Fa

Year: 2008

Venue: Ai zheng = Aizheng = Chinese journal of cancer

Paper MUTAGENESIS OF AAV CAPSID PROTEINS FOR ENHANCED TRANSDUCTION OF CARDIAC CELL TYPES

Latricia, Bowman, · 2015

Full title: MUTAGENESIS OF AAV CAPSID PROTEINS FOR ENHANCED TRANSDUCTION OF CARDIAC CELL TYPES

Authors: Latricia, Bowman,

Year: 2015

Paper [Resistance of rAAV2-MfE77.43-Transferred Mice to Schistosoma japonicum Infection].

Wang, Hong-mei; Xiong, De-hui; Luo, Sai-qun et al. · 2016 · Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases

Full title: [Resistance of rAAV2-MfE77.43-Transferred Mice to Schistosoma japonicum Infection].

Authors: Wang, Hong-mei; Xiong, De-hui; Luo, Sai-qun; Yang, Jie; Qian, Yin-jun; Qin, Zhi-qiang

Year: 2016

Venue: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases

Paper Recombinant Adeno-Associated Virus-Mediated Gene Therapy for Treatment of Familial Hypercholesterolemia in Rabbits

Atlas, Daniel; Buckshaw, Elizabeth; Hanna, David B. et al. · 2013 · University Libraries (University of Maryland)

Full title: Recombinant Adeno-Associated Virus-Mediated Gene Therapy for Treatment of Familial Hypercholesterolemia in Rabbits

Authors: Atlas, Daniel; Buckshaw, Elizabeth; Hanna, David B.; Lannon, Jennifer; Mahmud, Alia; Mirvis, Mary; Pham, Anna C.; Ramnarain, Nadira; Randazzo, Paul A.; Safferman, Michelle; Zuckerberg, Jeremy

Year: 2013

Venue: University Libraries (University of Maryland)

Paper [The construction of recombinant AAV vector expressing HSVtk gene controlled by Tet-On and the detection of its activity].

Chen, Qian; Li, Zi-Bo; Zeng, Zhao-Jun et al. · 2005 · Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Full title: [The construction of recombinant AAV vector expressing HSVtk gene controlled by Tet-On and the detection of its activity].

Authors: Chen, Qian; Li, Zi-Bo; Zeng, Zhao-Jun; Luo, Sai-Qun; Hu, Wei-Xin

Year: 2005

Venue: Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Paper Tuning capsid formation dynamics in recombinant adeno‐associated virus producing synthetic cell lines to enhance full particle productivity

Lu, Min; Lin, Yu‐Chieh; Kuo, Han‐Jung et al. · 2024 · Biotechnology Journal · DOI

Full title: Tuning capsid formation dynamics in recombinant adeno‐associated virus producing synthetic cell lines to enhance full particle productivity

Authors: Lu, Min; Lin, Yu‐Chieh; Kuo, Han‐Jung; Wen, Cai; Ye, Qian; Zhao, Liang; Hu, Wei‐Shou

Year: 2024

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202400051

Paper Unraveling Cytotoxicity in HEK293 Cells During Recombinant AAV Production for Gene Therapy Applications.

Ladiwala, Pranay; Ndahiro, Nelson; Hauk, Pricila et al. · 2025 · Biotechnology journal · DOI

Full title: Unraveling Cytotoxicity in HEK293 Cells During Recombinant AAV Production for Gene Therapy Applications.

Authors: Ladiwala, Pranay; Ndahiro, Nelson; Hauk, Pricila; Wen, Junneng; Sargunas, Justin; Chen, Yu-Ju; Barton, Erik; Betenbaugh, Michael J

Year: 2025

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202400501

Paper Towards a scalable bioprocess for rAAV production using a HeLa stable cell line.

Escandell, José; Moura, Filipa; Carvalho, Sofia B et al. · 2023 · Biotechnology and bioengineering · DOI

Full title: Towards a scalable bioprocess for rAAV production using a HeLa stable cell line.

Authors: Escandell, José; Moura, Filipa; Carvalho, Sofia B; Silva, Ricardo J S; Correia, Ricardo; Roldão, Antonio; Gomes-Alves, Patrícia; Alves, Paula M

Year: 2023

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28394

Paper Manufacturing of recombinant adeno-associated viruses using mammalian expression platforms.

Robert, Marc-André; Chahal, Parminder S; Audy, Alexandre et al. · 2017 · Biotechnology journal · DOI

Full title: Manufacturing of recombinant adeno-associated viruses using mammalian expression platforms.

Authors: Robert, Marc-André; Chahal, Parminder S; Audy, Alexandre; Kamen, Amine; Gilbert, Rénald; Gaillet, Bruno

Year: 2017

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201600193

Paper Rational plasmid design and bioprocess optimization to enhance recombinant adeno-associated virus (AAV) productivity in mammalian cells.

Emmerling, Verena V; Pegel, Antje; Milian, Ernest G et al. · 2016 · Biotechnology journal · DOI

Full title: Rational plasmid design and bioprocess optimization to enhance recombinant adeno-associated virus (AAV) productivity in mammalian cells.

Authors: Emmerling, Verena V; Pegel, Antje; Milian, Ernest G; Venereo-Sanchez, Alina; Kunz, Marion; Wegele, Jessica; Kamen, Amine A; Kochanek, Stefan; Hoerer, Markus

Year: 2016

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201500176

Paper Engineering of High-Yield Recombinant Adeno-Associated Virus Producer Plasmids.

Radukic, Marco T; Le, Dinh To; Freudenberg, Robert et al. · 2026 · Biotechnology journal · DOI

Full title: Engineering of High-Yield Recombinant Adeno-Associated Virus Producer Plasmids.

Authors: Radukic, Marco T; Le, Dinh To; Freudenberg, Robert; Hammann, Anne; Hamdan, Omar; Rothschild-Gronau, Claire; Hoffrogge, Raimund; Golm, Susanne K; Feiner, Rebecca C; Teschner, Kathrin E; Müller, Kristian M

Year: 2026

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.70179

Paper Production of adeno-associated viral vector serotype 6 by triple transfection of suspension HEK293 cells at higher cell densities.

Moço, Pablo D; Xu, Xingge; Silva, Cristina A T et al. · 2023 · Biotechnology journal · DOI

Full title: Production of adeno-associated viral vector serotype 6 by triple transfection of suspension HEK293 cells at higher cell densities.

Authors: Moço, Pablo D; Xu, Xingge; Silva, Cristina A T; Kamen, Amine A

Year: 2023

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202300051

Paper Enhancing the production of adeno-associated virus (AAV)2 and AAV9 with high full capsid ratio in HEK293 cells through design-of-experiment optimization of triple plasmid ratio.

Park, Sungje; Shin, Seunghyeon; Lee, Haeshin et al. · 2024 · Biotechnology journal · DOI

Full title: Enhancing the production of adeno-associated virus (AAV)2 and AAV9 with high full capsid ratio in HEK293 cells through design-of-experiment optimization of triple plasmid ratio.

Authors: Park, Sungje; Shin, Seunghyeon; Lee, Haeshin; Jang, Jae-Hyung; Lee, Gyun Min

Year: 2024

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202300667

Paper Advancements in molecular design and bioprocessing of recombinant adeno‐associated virus gene delivery vectors using the insect‐cell baculovirus expression platform

Joshi, Pranav R.H.; Venereo-Sánchez, Alina; Chahal, Parminder S. et al. · 2020 · Biotechnology Journal · DOI

Full title: Advancements in molecular design and bioprocessing of recombinant adeno‐associated virus gene delivery vectors using the insect‐cell baculovirus expression platform

Authors: Joshi, Pranav R.H.; Venereo-Sánchez, Alina; Chahal, Parminder S.; Kamen, Amine

Year: 2020

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202000021

Paper Comprehensive mRNA-sequencing-based characterization of three HEK-293 cell lines during an rAAV production process for gene therapy applications.

Pistek, Martina; Kahlig, Carolin-Isabel; Hackl, Matthias et al. · 2023 · Biotechnology journal · DOI

Full title: Comprehensive mRNA-sequencing-based characterization of three HEK-293 cell lines during an rAAV production process for gene therapy applications.

Authors: Pistek, Martina; Kahlig, Carolin-Isabel; Hackl, Matthias; Unterthurner, Sabine; Kraus, Barbara; Grabherr, Reingard; Grillari, Johannes; Hernandez Bort, Juan A

Year: 2023

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202200513

Paper Cas-CLOVER-mediated knockout of STAT1: A novel approach to engineer packaging HEK-293 cell lines used for rAAV production.

Andorfer, Peter; Kahlig, Carolin-Isabel; Pakusic, Doris et al. · 2024 · Biotechnology journal · DOI

Full title: Cas-CLOVER-mediated knockout of STAT1: A novel approach to engineer packaging HEK-293 cell lines used for rAAV production.

Authors: Andorfer, Peter; Kahlig, Carolin-Isabel; Pakusic, Doris; Pachlinger, Robert; John, Christiane; Schrenk, Irene; Eisenhut, Peter; Lengler, Johannes; Innthaler, Bernd; Micutkova, Lucia; Kraus, Barbara; Brizzee, Corey; Crawford, Jack; Hernandez Bort, Juan A

Year: 2024

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202400415

Paper Knockout of Pro-Apoptotic BAX and BAK1 Genes in HEK293T Cells Enhances Adeno-Associated Virus (AAV) Production: AAV2 and AAV9.

Park, Sungje; Shin, Seunghyeon; Han, Gyucheol et al. · 2025 · Biotechnology journal · DOI

Full title: Knockout of Pro-Apoptotic BAX and BAK1 Genes in HEK293T Cells Enhances Adeno-Associated Virus (AAV) Production: AAV2 and AAV9.

Authors: Park, Sungje; Shin, Seunghyeon; Han, Gyucheol; Lee, Gyun Min

Year: 2025

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202400529

Paper Intensification of rAAV Production Based on HEK293 Cell Transient Transfection.

Zhang, Ye; Peters, Emil Sundäng; Daramola, Olalekan et al. · 2025 · Biotechnology journal · DOI

Full title: Intensification of rAAV Production Based on HEK293 Cell Transient Transfection.

Authors: Zhang, Ye; Peters, Emil Sundäng; Daramola, Olalekan; Tucker, Trudy Ann; Rockberg, Johan; Hatton, Diane; Chotteau, Véronique

Year: 2025

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.70020

Paper Critical challenges and advances in recombinant adeno‐associated virus (rAAV) biomanufacturing

Fu, Qiang; Polanco, Ashli; Lee, Yong Suk et al. · 2023 · Biotechnology and Bioengineering · DOI

Full title: Critical challenges and advances in recombinant adeno‐associated virus (rAAV) biomanufacturing

Authors: Fu, Qiang; Polanco, Ashli; Lee, Yong Suk; Yoon, Seongkyu

Year: 2023

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28412

Paper Enhanced Adeno‐Associated Virus Production in HEK293 Cells via Dual Inducible Control of Cap and Rep Proteins

He Ren; Jianqi Nie; Zichuan Song et al. · 2025 · Biotechnology and Bioengineering · DOI

Full title: Enhanced Adeno‐Associated Virus Production in HEK293 Cells via Dual Inducible Control of Cap and Rep Proteins

Authors: He Ren; Jianqi Nie; Zichuan Song; Yankun Yang; Zhonghu Bai

Year: 2025

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.70013

Paper Molecular design of controllable recombinant adeno-associated virus (AAV) expression systems for enhanced vector production.

Johari, Yusuf B; Pohle, Thilo H; Whitehead, Jared et al. · 2024 · Biotechnology journal · DOI

Full title: Molecular design of controllable recombinant adeno-associated virus (AAV) expression systems for enhanced vector production.

Authors: Johari, Yusuf B; Pohle, Thilo H; Whitehead, Jared; Scarrott, Joseph M; Liu, Ping; Mayer, Ayda; James, David C

Year: 2024

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202300685

Paper Development of an HEK293 Suspension Cell Culture Medium, Transient Transfection Optimization Workflow, and Analytics for Batch rAAV Manufacturing.

Green, Erica A; Fu, Qiang; Ndahiro, Nelson et al. · 2025 · Biotechnology and bioengineering · DOI

Full title: Development of an HEK293 Suspension Cell Culture Medium, Transient Transfection Optimization Workflow, and Analytics for Batch rAAV Manufacturing.

Authors: Green, Erica A; Fu, Qiang; Ndahiro, Nelson; Leibiger, Thomas M; Wang, Yongdan; Lee, Yongsuk; Lee, Kelvin H; Betenbaugh, Michael; Yoon, Seongkyu; McNally, David J

Year: 2025

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28980

Paper Expression of Viral DNA Polymerase in Synthetic Recombinant Adeno-Associated Virus Producer Cell Line Enhances Full Particle Productivity.

Lin, Yu-Chieh; Kuo, Han-Jung; Lu, Min et al. · 2025 · Biotechnology and bioengineering · DOI

Full title: Expression of Viral DNA Polymerase in Synthetic Recombinant Adeno-Associated Virus Producer Cell Line Enhances Full Particle Productivity.

Authors: Lin, Yu-Chieh; Kuo, Han-Jung; Lu, Min; Rungkittikhun, Carissa; Hu, Wei-Shou

Year: 2025

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28885

Paper Comparative Analysis of HEK293 Genomic Variability.

Smesnik, Georg; Virgolini, Nikolaus; Toth, Maria et al. · 2026 · Biotechnology and bioengineering · DOI

Full title: Comparative Analysis of HEK293 Genomic Variability.

Authors: Smesnik, Georg; Virgolini, Nikolaus; Toth, Maria; Dürauer, Astrid; Borth, Nicole

Year: 2026

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.70105

Paper Multidose transient transfection of human embryonic kidney 293 cells modulates recombinant adeno-associated virus2/5 Rep protein expression and influences the enrichment fraction of filled capsids.

Srinivasan, Prasanna; Canova, Christopher T; Sha, Sha et al. · 2024 · Biotechnology and bioengineering · DOI

Full title: Multidose transient transfection of human embryonic kidney 293 cells modulates recombinant adeno-associated virus2/5 Rep protein expression and influences the enrichment fraction of filled capsids.

Authors: Srinivasan, Prasanna; Canova, Christopher T; Sha, Sha; Nguyen, Tam N T; Joseph, John; Sangerman, Jose; Maloney, Andrew J; Katsikis, Georgios; Ou, Rui Wen; Hong, Moo Sun; Ng, Jaclyn; Yuan, Arella; Antov, Daniel; Song, Sally; Chen, Wenyu; Neufeld, Caleb; Wolfrum, Jacqueline M; Barone, Paul W; Sinskey, Anthony J; Springs, Stacy L; Braatz, Richard D

Year: 2024

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28828

Paper Accelerated Adeno Associated Virus Upstream Process Development From High‐Throughput Systems to Clinical Scale

Andaluz, Anna; Monteverde, Brittany; Vera, Kevin et al. · 2025 · Biotechnology and Bioengineering · DOI

Full title: Accelerated Adeno Associated Virus Upstream Process Development From High‐Throughput Systems to Clinical Scale

Authors: Andaluz, Anna; Monteverde, Brittany; Vera, Kevin; Tse, Brian WC; Gajic, Ivan; Forelich, Clifford; Motevalian, Seyed Pouria

Year: 2025

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.70052

Paper Design space determination to optimize DNA complexation and full capsid formation in transient rAAV manufacturing

Fu, Qiang; Lee, Yong Suk; Green, Erica A. et al. · 2023 · Biotechnology and Bioengineering · DOI

Full title: Design space determination to optimize DNA complexation and full capsid formation in transient rAAV manufacturing

Authors: Fu, Qiang; Lee, Yong Suk; Green, Erica A.; Wang, Yongdan; Park, So Young; Polanco, Ashli; Lee, Kelvin H.; Betenbaugh, Michael J.; McNally, David; Yoon, Seongkyu

Year: 2023

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.28508

Paper Iterative hybrid model based optimization of rAAV production.

Müller, Claudio; Siegwart, Gerald; Heider, Susanne et al. · 2025 · Biotechnology progress · DOI

Full title: Iterative hybrid model based optimization of rAAV production.

Authors: Müller, Claudio; Siegwart, Gerald; Heider, Susanne; Sokolov, Michael; Botros, Angela; Umprecht, Alexandra; von Stosch, Moritz; Cruz Bournazou, Mariano Nicolas

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.70006

Paper How will the field of gene therapy survive its success?

Kaemmerer, William F. · 2018 · Bioengineering & Translational Medicine · DOI

Full title: How will the field of gene therapy survive its success?

Authors: Kaemmerer, William F.

Year: 2018

Venue: Bioengineering & Translational Medicine

DOI: https://doi.org/10.1002/btm2.10090

Paper High-yield recombinant adeno-associated viral vector production by multivariate optimization of bioprocess and transfection conditions.

Coplan, Louis; Zhang, Zhe; Ragone, Nicole et al. · 2024 · Biotechnology progress · DOI

Full title: High-yield recombinant adeno-associated viral vector production by multivariate optimization of bioprocess and transfection conditions.

Authors: Coplan, Louis; Zhang, Zhe; Ragone, Nicole; Reeves, John; Rodriguez, Audrey; Shevade, Aishwarya; Bak, Hanne; Tustian, Andrew D

Year: 2024

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3445

Paper Harnessing cell aggregates for enhanced adeno-associated virus manufacturing: Cultivation strategies and scale-up considerations.

Ladd, Brian; Gräslund, Torbjörn; Chotteau, Véronique · 2025 · Biotechnology progress · DOI

Full title: Harnessing cell aggregates for enhanced adeno-associated virus manufacturing: Cultivation strategies and scale-up considerations.

Authors: Ladd, Brian; Gräslund, Torbjörn; Chotteau, Véronique

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3522

Paper Transcriptomic functional characterization of recombinant adeno-associated virus producing cell line adapted to suspension-growth.

Kuo, Han-Jung; Srinivasan, Prahalad; Lin, Yu-Chieh et al. · 2025 · Biotechnology progress · DOI

Full title: Transcriptomic functional characterization of recombinant adeno-associated virus producing cell line adapted to suspension-growth.

Authors: Kuo, Han-Jung; Srinivasan, Prahalad; Lin, Yu-Chieh; Lu, Min; Rungkittikhun, Carissa; Zhang, Qi; Hu, Wei-Shou

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.70042

Paper Improving the expression yield of recombinant adeno-associated virus serotype 2 using dimethyl sulfoxide DMSO as an additive to the triple transient transfection process of HEK293 cells.

Burns, Alexander; Ramos-Sono, Daniel; Datta, Saurav · 2025 · Biotechnology progress · DOI

Full title: Improving the expression yield of recombinant adeno-associated virus serotype 2 using dimethyl sulfoxide DMSO as an additive to the triple transient transfection process of HEK293 cells.

Authors: Burns, Alexander; Ramos-Sono, Daniel; Datta, Saurav

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.70017

Paper A synthetic platform for developing recombinant adeno-associated virus type 8 producer cell lines.

Lin, Yu-Chieh; Kuo, Han-Jung; Lu, Min et al. · 2025 · Biotechnology progress · DOI

Full title: A synthetic platform for developing recombinant adeno-associated virus type 8 producer cell lines.

Authors: Lin, Yu-Chieh; Kuo, Han-Jung; Lu, Min; Mahl, Thomas; Aslanidi, George; Hu, Wei-Shou

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.70009

Paper AAV Gene Transfer to the Heart.

Wang, Suya; Guo, Yuxuan; Pu, William T · 2021 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: AAV Gene Transfer to the Heart.

Authors: Wang, Suya; Guo, Yuxuan; Pu, William T

Year: 2021

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-0716-0668-1_20

Paper Perfusion-Based Production of rAAV via an Intensified Transient Transfection Process.

Nguyen, Tam N T; Park, Damdae; Canova, Christopher T et al. · 2025 · Biotechnology and bioengineering · DOI

Full title: Perfusion-Based Production of rAAV via an Intensified Transient Transfection Process.

Authors: Nguyen, Tam N T; Park, Damdae; Canova, Christopher T; Sangerman, Jose; Srinivasan, Prasanna; Ou, Rui Wen; Barone, Paul W; Neufeld, Caleb; Wolfrum, Jacqueline M; Springs, Stacy L; Sinskey, Anthony J; Braatz, Richard D

Year: 2025

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28967

Paper Extracellular vesicles enhance pulmonary transduction of stably associated adeno‐associated virus following intratracheal administration

Kwak, Gijung; Гололобова, Олеся; Sharma, Neeraj et al. · 2023 · Journal of Extracellular Vesicles · DOI

Full title: Extracellular vesicles enhance pulmonary transduction of stably associated adeno‐associated virus following intratracheal administration

Authors: Kwak, Gijung; Гололобова, Олеся; Sharma, Neeraj; Caine, Colin; Mazur, Marina; Mulka, Kathleen R.; West, Natalie E.; Solomon, George M.; Cutting, Garry R.; Witwer, Kenneth W.; Rowe, Steven M.; Paulaitis, Michael E.; Aslanidi, George; Suk, Jung Soo

Year: 2023

Venue: Journal of Extracellular Vesicles

DOI: https://doi.org/10.1002/jev2.12324

Paper Production and Purification of Adeno-Associated Viral Vectors (AAVs) Using Orbitally Shaken HEK293 Cells.

Gaudry, Jean-Philippe; Aebi, Aline; Valdés, Pamela et al. · 2024 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Production and Purification of Adeno-Associated Viral Vectors (AAVs) Using Orbitally Shaken HEK293 Cells.

Authors: Gaudry, Jean-Philippe; Aebi, Aline; Valdés, Pamela; Schneider, Bernard L

Year: 2024

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-0716-3878-1_4

Paper Adeno-Associated Virus Production, Purification, and Titering.

Chen, Yong Hong; Keiser, Megan S; Davidson, Beverly L · 2018 · Current protocols in mouse biology · DOI

Full title: Adeno-Associated Virus Production, Purification, and Titering.

Authors: Chen, Yong Hong; Keiser, Megan S; Davidson, Beverly L

Year: 2018

Venue: Current protocols in mouse biology

DOI: https://doi.org/10.1002/cpmo.56

Paper Scalable Production and Purification of Adeno-Associated Viral Vectors (AAV).

Blessing, Daniel; Déglon, Nicole; Schneider, Bernard L · 2018 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Scalable Production and Purification of Adeno-Associated Viral Vectors (AAV).

Authors: Blessing, Daniel; Déglon, Nicole; Schneider, Bernard L

Year: 2018

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-4939-8730-6_17

Paper A Rapid, Cost-Effective Method to Prepare Recombinant Adeno-Associated Virus for Efficient Gene Transfer to the Developing Mouse Inner Ear.

Gomes, Michelle M; Wang, Lingyan; Jiang, Han et al. · 2016 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: A Rapid, Cost-Effective Method to Prepare Recombinant Adeno-Associated Virus for Efficient Gene Transfer to the Developing Mouse Inner Ear.

Authors: Gomes, Michelle M; Wang, Lingyan; Jiang, Han; Kahl, Christoph A; Brigande, John V

Year: 2016

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-4939-3615-1_3

Paper A DNA vaccine containing inverted terminal repeats from adeno-associated virus increases immunity to HIV.

Xin, Ke-Qin; Ooki, Takaaki; Jounai, Nao et al. · 2003 · The journal of gene medicine · DOI

Full title: A DNA vaccine containing inverted terminal repeats from adeno-associated virus increases immunity to HIV.

Authors: Xin, Ke-Qin; Ooki, Takaaki; Jounai, Nao; Mizukami, Hiroaki; Hamajima, Kenji; Kojima, Yoshitsugu; Ohba, Kenji; Toda, Yoshihiko; Hirai, Syu-Ichi; Klinman, Dennis M; Ozawa, Keiya; Okuda, Kenji

Year: 2003

Venue: The journal of gene medicine

DOI: https://doi.org/10.1002/jgm.356

Paper Real-Time VCC Monitoring and Forecasting in HEK-Cell-Based rAAV Vector Production Using Capacitance Spectroscopy.

Machleid, Rafael; Nunna, Suneetha; George, Ajith et al. · 2025 · Engineering in life sciences · DOI

Full title: Real-Time VCC Monitoring and Forecasting in HEK-Cell-Based rAAV Vector Production Using Capacitance Spectroscopy.

Authors: Machleid, Rafael; Nunna, Suneetha; George, Ajith; Austerjost, Jonas; Tomala, Magda; Surowiec, Izabella

Year: 2025

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.70004

Paper AAV Production Everywhere: A Simple, Fast, and Reliable Protocol for In-house AAV Vector Production Based on Chloroform Extraction.

Negrini, Matilde; Wang, Gang; Heuer, Andreas et al. · 2020 · Current protocols in neuroscience · DOI

Full title: AAV Production Everywhere: A Simple, Fast, and Reliable Protocol for In-house AAV Vector Production Based on Chloroform Extraction.

Authors: Negrini, Matilde; Wang, Gang; Heuer, Andreas; Björklund, Tomas; Davidsson, Marcus

Year: 2020

Venue: Current protocols in neuroscience

DOI: https://doi.org/10.1002/cpns.103

Paper AAV Vectors for Efficient Gene Delivery to Rodent Hearts.

Lopez-Gordo, Estrella; Kohlbrenner, Erik; Katz, Michael G et al. · 2019 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: AAV Vectors for Efficient Gene Delivery to Rodent Hearts.

Authors: Lopez-Gordo, Estrella; Kohlbrenner, Erik; Katz, Michael G; Weber, Thomas

Year: 2019

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-4939-9139-6_19

Paper In Vivo Delivery of Cassettes Encoding Anti-HBV Primary MicroRNAs Using an Ancestral Adeno-Associated Viral Vector.

Mnyandu, Njabulo; Arbuthnot, Patrick; Maepa, Mohube Betty · 2020 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: In Vivo Delivery of Cassettes Encoding Anti-HBV Primary MicroRNAs Using an Ancestral Adeno-Associated Viral Vector.

Authors: Mnyandu, Njabulo; Arbuthnot, Patrick; Maepa, Mohube Betty

Year: 2020

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-0716-0290-4_10

Paper Host cells and cell banking.

Stacey, Glyn N; Merten, Otto-Wilhelm · 2011 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Host cells and cell banking.

Authors: Stacey, Glyn N; Merten, Otto-Wilhelm

Year: 2011

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-61779-095-9_3

Paper Silencing Genes in the Heart.

Fechner, Henry; Vetter, Roland; Kurreck, Jens et al. · 2017 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Silencing Genes in the Heart.

Authors: Fechner, Henry; Vetter, Roland; Kurreck, Jens; Poller, Wolfgang

Year: 2017

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-4939-6588-5_2

Paper Transfection and DNA-mediated gene transfer.

Zecchin, Davide; Di Nicolantonio, Federica · 2011 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Transfection and DNA-mediated gene transfer.

Authors: Zecchin, Davide; Di Nicolantonio, Federica

Year: 2011

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-61779-080-5_35

Paper Vector systems for prenatal gene therapy: principles of adeno-associated virus vector design and production.

Binny, Christopher J; Nathwani, Amit C · 2012 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Vector systems for prenatal gene therapy: principles of adeno-associated virus vector design and production.

Authors: Binny, Christopher J; Nathwani, Amit C

Year: 2012

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-61779-873-3_6

Paper Production and Characterization of Vectors Based on the Cardiotropic AAV Serotype 9.

Kohlbrenner, Erik; Weber, Thomas · 2017 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Production and Characterization of Vectors Based on the Cardiotropic AAV Serotype 9.

Authors: Kohlbrenner, Erik; Weber, Thomas

Year: 2017

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-4939-6588-5_6

Paper Enhanced cellular transfection by ternary non-viral gene vectors coupled with adeno-associated virus-derived peptides.

Oh, Ji-Seon; Park, Minah; Kim, Jung-Suk et al. · 2014 · Macromolecular bioscience · DOI

Full title: Enhanced cellular transfection by ternary non-viral gene vectors coupled with adeno-associated virus-derived peptides.

Authors: Oh, Ji-Seon; Park, Minah; Kim, Jung-Suk; Jang, Jae-Hyung

Year: 2014

Venue: Macromolecular bioscience

DOI: https://doi.org/10.1002/mabi.201300296

Paper Bioluminescence-based monitoring of virus vector-mediated gene transfer in mice.

Maguire, Casey A · 2014 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Bioluminescence-based monitoring of virus vector-mediated gene transfer in mice.

Authors: Maguire, Casey A

Year: 2014

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-62703-718-1_16

Paper Rescue of avian adeno-associated virus from a recombinant plasmid containing deletions in the viral inverted terminal repeats.

Wang, Jianye; Zhu, Liqian; Zhu, Jun et al. · 2012 · Archives of virology · DOI

Full title: Rescue of avian adeno-associated virus from a recombinant plasmid containing deletions in the viral inverted terminal repeats.

Authors: Wang, Jianye; Zhu, Liqian; Zhu, Jun; Zhang, Xinjun; Tao, Jie; Duan, Qiangde; Zhu, Guoqiang

Year: 2012

Venue: Archives of virology

DOI: https://doi.org/10.1007/s00705-011-1121-x

Paper A feasibility study of different commercially available serum-free mediums to enhance lentivirus and adeno-associated virus production in HEK 293 suspension cells.

Celebi Torabfam, Gizem; Yetisgin, Abuzer Alp; Erdem, Cem et al. · 2022 · Cytotechnology · DOI

Full title: A feasibility study of different commercially available serum-free mediums to enhance lentivirus and adeno-associated virus production in HEK 293 suspension cells.

Authors: Celebi Torabfam, Gizem; Yetisgin, Abuzer Alp; Erdem, Cem; Cayli, Aziz; Kutlu, Ozlem; Cetinel, Sibel

Year: 2022

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-022-00551-1

Paper Exploring the design space of AAV transient-transfection in suspension cell lines.

Meade, Oliver; Clark, Jeffrey; McCutchen, Michael et al. · 2021 · Methods in enzymology · DOI

Full title: Exploring the design space of AAV transient-transfection in suspension cell lines.

Authors: Meade, Oliver; Clark, Jeffrey; McCutchen, Michael; Kerwin, John

Year: 2021

Venue: Methods in enzymology

DOI: https://doi.org/10.1016/bs.mie.2021.08.003

Paper Improved productivity of recombinant adeno-associated virus (rAAV) via triple transfection of HEK293 cells using perfusion cultivation.

Nie, Jianqi; Xu, Zhaojing; Sun, Yang et al. · 2025 · Bioprocess and biosystems engineering · DOI

Full title: Improved productivity of recombinant adeno-associated virus (rAAV) via triple transfection of HEK293 cells using perfusion cultivation.

Authors: Nie, Jianqi; Xu, Zhaojing; Sun, Yang; Ren, He; Song, Zichuan; Zhang, Yan; Bai, Zhonghu

Year: 2025

Venue: Bioprocess and biosystems engineering

DOI: https://doi.org/10.1007/s00449-025-03167-9

Paper Construction and gene expression analysis of a single-stranded DNA minivector based on an inverted terminal repeat of adeno-associated virus.

Ping, Han; Liu, Xiaomei; Zhu, Dongqin et al. · 2015 · Molecular biotechnology · DOI

Full title: Construction and gene expression analysis of a single-stranded DNA minivector based on an inverted terminal repeat of adeno-associated virus.

Authors: Ping, Han; Liu, Xiaomei; Zhu, Dongqin; Li, Taiming; Zhang, Chun

Year: 2015

Venue: Molecular biotechnology

DOI: https://doi.org/10.1007/s12033-014-9832-3

Paper Construction of adeno-associated virus system for human bone morphogenetic protein 7 gene.

Song, Ke; Rao, Nianjing; Chen, Meiling et al. · 2008 · Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · DOI

Full title: Construction of adeno-associated virus system for human bone morphogenetic protein 7 gene.

Authors: Song, Ke; Rao, Nianjing; Chen, Meiling; Cao, Yingguang

Year: 2008

Venue: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban

DOI: https://doi.org/10.1007/s11596-008-0105-x

Paper Enhancement of chitosan-mediated gene delivery through combination with phiC31 integrase.

Oliveira, Ana Vanessa Vieira; Silva, Gabriela Araújo; Chung, Daniel C · 2015 · Acta biomaterialia · DOI

Full title: Enhancement of chitosan-mediated gene delivery through combination with phiC31 integrase.

Authors: Oliveira, Ana Vanessa Vieira; Silva, Gabriela Araújo; Chung, Daniel C

Year: 2015

Venue: Acta biomaterialia

DOI: https://doi.org/10.1016/j.actbio.2015.01.013

Paper Transduction efficiency of AAV 2/6, 2/8 and 2/9 vectors for delivering genes in human corneal fibroblasts.

Sharma, Ajay; Ghosh, Arkasubhra; Hansen, Eric T et al. · 2010 · Brain research bulletin · DOI

Full title: Transduction efficiency of AAV 2/6, 2/8 and 2/9 vectors for delivering genes in human corneal fibroblasts.

Authors: Sharma, Ajay; Ghosh, Arkasubhra; Hansen, Eric T; Newman, Jason M; Mohan, Rajiv R

Year: 2010

Venue: Brain research bulletin

DOI: https://doi.org/10.1016/j.brainresbull.2009.07.005

Paper The use of melittin to enhance transgene expression mediated by recombinant adeno-associated virus serotype 2 vectors both in vitro and in vivo.

Xie, Yi-Lin; Wang, Ji-Yao; He, Yun et al. · 2023 · Journal of integrative medicine · DOI

Full title: The use of melittin to enhance transgene expression mediated by recombinant adeno-associated virus serotype 2 vectors both in vitro and in vivo.

Authors: Xie, Yi-Lin; Wang, Ji-Yao; He, Yun; Yu, Xiao-Min; Zheng, Qing-Yun; Ling, Chen; Feng, Xi-Lin; Zhu, Li-Qing

Year: 2023

Venue: Journal of integrative medicine

DOI: https://doi.org/10.1016/j.joim.2022.10.003

Paper Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing

O’Flaherty, Róisín; Bergin, Adam; Flampouri, Evangelia et al. · 2020 · Biotechnology Advances · DOI

Full title: Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing

Authors: O’Flaherty, Róisín; Bergin, Adam; Flampouri, Evangelia; Mota, Letícia Martins; Obaidi, Ismael; Quigley, Andrew; Xie, Yongjing; Butler, Michael

Year: 2020

Venue: Biotechnology Advances

DOI: https://doi.org/10.1016/j.biotechadv.2020.107552

Paper The Unveiled Novel regulator of Adeno-associated virus production in HEK293 cells.

Yan, Junyu; Li, Ziqian; Shu, Yue et al. · 2025 · Gene · DOI

Full title: The Unveiled Novel regulator of Adeno-associated virus production in HEK293 cells.

Authors: Yan, Junyu; Li, Ziqian; Shu, Yue; Chen, Hui; Wang, Tianxingzi; Li, Xin; Zhang, Yuhang; Li, LiLi; Zhang, Yuntao

Year: 2025

Venue: Gene

DOI: https://doi.org/10.1016/j.gene.2024.149122

Paper Immunogenicity of an adeno-vector vaccine expressing the F protein of a respiratory syncytial virus manufactured from serum-free suspension culture.

Shao, Hsiao-Yun; Hsu, Huai-Sheng; Yu, Shu-Ling et al. · 2016 · Antiviral research · DOI

Full title: Immunogenicity of an adeno-vector vaccine expressing the F protein of a respiratory syncytial virus manufactured from serum-free suspension culture.

Authors: Shao, Hsiao-Yun; Hsu, Huai-Sheng; Yu, Shu-Ling; Wu, Shang-Rung; Hu, Kai-Chieh; Chang, Ching-Kun; Liu, Chia-Chyi; Chow, Yen-Hung

Year: 2016

Venue: Antiviral research

DOI: https://doi.org/10.1016/j.antiviral.2016.03.011

Paper Orthogonal characterization of rAAV9 reveals unexpected transgene heterogeneity.

Eisenhut, Peter; Andorfer, Peter; Haid, Andrea et al. · 2024 · Journal of biotechnology · DOI

Full title: Orthogonal characterization of rAAV9 reveals unexpected transgene heterogeneity.

Authors: Eisenhut, Peter; Andorfer, Peter; Haid, Andrea; Jokl, Beatrice; Manhartsberger, Raffaela; Fuchsberger, Felix; Innthaler, Bernd; Lengler, Johannes; Kraus, Barbara; Pletzenauer, Robert; Hernandez Bort, Juan A; Unterthurner, Sabine

Year: 2024

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2024.07.020

Paper Potency by design: Novel insights in transfection and purification for manufacturing of rAAV gene therapy vectors.

Maccani, Andreas; Pachlinger, Robert; Eisenhut, Peter et al. · 2025 · Journal of biotechnology · DOI

Full title: Potency by design: Novel insights in transfection and purification for manufacturing of rAAV gene therapy vectors.

Authors: Maccani, Andreas; Pachlinger, Robert; Eisenhut, Peter; Unterthurner, Sabine; Heider, Susanne; Repik, Christoph; Reuberger, Stefan; Andorfer, Peter; Lengler, Johannes; Kinastberger, Bernhard; Seczer, Dieter; Gruber, Petra; Apschner, Alexander; Micutkova, Lucia

Year: 2025

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2024.12.007

Paper Therapeutic potential of AAV8-mediated IL-17RA extracellular domain gene delivery in an imiquimod-induced mouse model of psoriasis.

Xie, Huibin; Li, Danping; Cao, Yu et al. · 2025 · Molecular immunology · DOI

Full title: Therapeutic potential of AAV8-mediated IL-17RA extracellular domain gene delivery in an imiquimod-induced mouse model of psoriasis.

Authors: Xie, Huibin; Li, Danping; Cao, Yu; Lv, Yafeng; Cao, Chunyu; Wu, Hongyan

Year: 2025

Venue: Molecular immunology

DOI: https://doi.org/10.1016/j.molimm.2025.11.001

Paper Production of adeno-associated virus (AAV) serotypes by transient transfection of HEK293 cell suspension cultures for gene delivery.

Chahal, Parminder Singh; Schulze, Erica; Tran, Rosa et al. · 2014 · Journal of virological methods · DOI

Full title: Production of adeno-associated virus (AAV) serotypes by transient transfection of HEK293 cell suspension cultures for gene delivery.

Authors: Chahal, Parminder Singh; Schulze, Erica; Tran, Rosa; Montes, Johnny; Kamen, Amine A

Year: 2014

Venue: Journal of virological methods

DOI: https://doi.org/10.1016/j.jviromet.2013.10.038

Paper Efficient production of an avian adeno-associated virus vector using insect cell/baculovirus expression system.

Wang, Anping; Wang, Yongjuan; Wu, Shuang et al. · 2017 · Journal of virological methods · DOI

Full title: Efficient production of an avian adeno-associated virus vector using insect cell/baculovirus expression system.

Authors: Wang, Anping; Wang, Yongjuan; Wu, Shuang; Zuo, Weiyong; Guo, Changming; Hong, Weiming; Zhu, Shanyuan

Year: 2017

Venue: Journal of virological methods

DOI: https://doi.org/10.1016/j.jviromet.2016.11.005

Paper Scalable serum-free production of recombinant adeno-associated virus type 2 by transfection of 293 suspension cells.

Durocher, Yves; Pham, Phuong Lan; St-Laurent, Gilles et al. · 2007 · Journal of virological methods · DOI

Full title: Scalable serum-free production of recombinant adeno-associated virus type 2 by transfection of 293 suspension cells.

Authors: Durocher, Yves; Pham, Phuong Lan; St-Laurent, Gilles; Jacob, Danielle; Cass, Brian; Chahal, Parminder; Lau, Cara J; Nalbantoglu, Joséphine; Kamen, Amine

Year: 2007

Venue: Journal of virological methods

DOI: https://doi.org/10.1016/j.jviromet.2007.03.014

Paper Rapid and simplified purification of recombinant adeno-associated virus.

Guo, Ping; El-Gohary, Yousef; Prasadan, Krishna et al. · 2012 · Journal of virological methods · DOI

Full title: Rapid and simplified purification of recombinant adeno-associated virus.

Authors: Guo, Ping; El-Gohary, Yousef; Prasadan, Krishna; Shiota, Chiyo; Xiao, Xiangwei; Wiersch, John; Paredes, Jose; Tulachan, Sidhartha; Gittes, George K

Year: 2012

Venue: Journal of virological methods

DOI: https://doi.org/10.1016/j.jviromet.2012.04.004

Paper Noninvasive focused ultrasound-mediated delivery of rAAV9-EGFP vectors for neuronal targeting in rats.

Wang, Rui; Li, Jiayi · 2024 · NeuroImage · DOI

Full title: Noninvasive focused ultrasound-mediated delivery of rAAV9-EGFP vectors for neuronal targeting in rats.

Authors: Wang, Rui; Li, Jiayi

Year: 2024

Venue: NeuroImage

DOI: https://doi.org/10.1016/j.neuroimage.2024.120630

Paper DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease.

Arkan, Sertan; Ljungberg, Mårten; Kirik, Deniz et al. · 2021 · Neurobiology of disease · DOI

Full title: DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease.

Authors: Arkan, Sertan; Ljungberg, Mårten; Kirik, Deniz; Hansen, Christian

Year: 2021

Venue: Neurobiology of disease

DOI: https://doi.org/10.1016/j.nbd.2021.105477

Paper Transfection of mammalian cells using linear polyethylenimine is a simple and effective means of producing recombinant adeno-associated virus vectors.

Reed, Sharon E; Staley, Elizabeth M; Mayginnes, John P et al. · 2006 · Journal of virological methods · DOI

Full title: Transfection of mammalian cells using linear polyethylenimine is a simple and effective means of producing recombinant adeno-associated virus vectors.

Authors: Reed, Sharon E; Staley, Elizabeth M; Mayginnes, John P; Pintel, David J; Tullis, Gregory E

Year: 2006

Venue: Journal of virological methods

DOI: https://doi.org/10.1016/j.jviromet.2006.07.024

Paper Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells.

Nguyen, Tam N T; Sha, Sha; Hong, Moo Sun et al. · 2021 · Molecular therapy. Methods & clinical development · DOI

Full title: Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells.

Authors: Nguyen, Tam N T; Sha, Sha; Hong, Moo Sun; Maloney, Andrew J; Barone, Paul W; Neufeld, Caleb; Wolfrum, Jacqueline; Springs, Stacy L; Sinskey, Anthony J; Braatz, Richard D

Year: 2021

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2021.04.006

Paper AAV2-mediated ABD-FGF21 gene delivery produces a sustained anti-hyperglycemic effect in type 2 diabetic mouse.

Lu, Sen-Lin; Pan, Zhi-Hao; Cui, Zhi et al. · 2025 · Life sciences · DOI

Full title: AAV2-mediated ABD-FGF21 gene delivery produces a sustained anti-hyperglycemic effect in type 2 diabetic mouse.

Authors: Lu, Sen-Lin; Pan, Zhi-Hao; Cui, Zhi; Wang, Ji-Li; Yang, Jian-Lin; Lv, Ya-Feng; Cao, Chun-Yu; Huang, Xiao-Fei

Year: 2025

Venue: Life sciences

DOI: https://doi.org/10.1016/j.lfs.2024.123344

Paper Preclinical Development of an AAV8-hUGT1A1 Vector for the Treatment of Crigler-Najjar Syndrome.

Collaud, Fanny; Bortolussi, Giulia; Guianvarc'h, Laurence et al. · 2019 · Molecular therapy. Methods & clinical development · DOI

Full title: Preclinical Development of an AAV8-hUGT1A1 Vector for the Treatment of Crigler-Najjar Syndrome.

Authors: Collaud, Fanny; Bortolussi, Giulia; Guianvarc'h, Laurence; Aronson, Sem J; Bordet, Thierry; Veron, Philippe; Charles, Severine; Vidal, Patrice; Sola, Marcelo Simon; Rundwasser, Stephanie; Dufour, Delphine G; Lacoste, Florence; Luc, Cyril; Wittenberghe, Laetitia V; Martin, Samia; Le Bec, Christine; Bosma, Piter J; Muro, Andres F; Ronzitti, Giuseppe; Hebben, Matthias; Mingozzi, Federico

Year: 2019

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2018.12.011

Paper Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells.

Blessing, Daniel; Vachey, Gabriel; Pythoud, Catherine et al. · 2019 · Molecular therapy. Methods & clinical development · DOI

Full title: Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells.

Authors: Blessing, Daniel; Vachey, Gabriel; Pythoud, Catherine; Rey, Maria; Padrun, Vivianne; Wurm, Florian M; Schneider, Bernard L; Déglon, Nicole

Year: 2019

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2018.11.004

Paper Recombinant AAV genome size effect on viral vector production, purification, and thermostability.

Ibreljic, Nermin; Draper, Benjamin E; Lawton, Carl W · 2024 · Molecular therapy. Methods & clinical development · DOI

Full title: Recombinant AAV genome size effect on viral vector production, purification, and thermostability.

Authors: Ibreljic, Nermin; Draper, Benjamin E; Lawton, Carl W

Year: 2024

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2024.101188

Paper Production of rAAV by plasmid transfection induces antiviral and inflammatory responses in suspension HEK293 cells.

Chung, Cheng-Han; Murphy, Christopher M; Wingate, Vincent P et al. · 2023 · Molecular therapy. Methods & clinical development · DOI

Full title: Production of rAAV by plasmid transfection induces antiviral and inflammatory responses in suspension HEK293 cells.

Authors: Chung, Cheng-Han; Murphy, Christopher M; Wingate, Vincent P; Pavlicek, Jeffrey W; Nakashima, Reiko; Wei, Wei; McCarty, Douglas; Rabinowitz, Joseph; Barton, Erik

Year: 2023

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2023.01.002

Paper Methods Matter: Standard Production Platforms for Recombinant AAV Produce Chemically and Functionally Distinct Vectors.

Rumachik, Neil G; Malaker, Stacy A; Poweleit, Nicole et al. · 2020 · Molecular therapy. Methods & clinical development · DOI

Full title: Methods Matter: Standard Production Platforms for Recombinant AAV Produce Chemically and Functionally Distinct Vectors.

Authors: Rumachik, Neil G; Malaker, Stacy A; Poweleit, Nicole; Maynard, Lucy H; Adams, Christopher M; Leib, Ryan D; Cirolia, Giana; Thomas, Dennis; Stamnes, Susan; Holt, Kathleen; Sinn, Patrick; May, Andrew P; Paulk, Nicole K

Year: 2020

Venue: Molecular therapy. Methods & clinical development

DOI: https://doi.org/10.1016/j.omtm.2020.05.018

Thesis Self-assembling poly(L-lysine)/DNA complexes capable of integrin- mediated cellular uptake and gene expression

Carlisle, Robert C.; Read, Martin L.; Wolfert, Margreet A. et al. · 1999 · Utrecht University · DOI

Full title: Self-assembling poly(L-lysine)/DNA complexes capable of integrin- mediated cellular uptake and gene expression

Authors: Carlisle, Robert C.; Read, Martin L.; Wolfert, Margreet A.; Seymour, Leonard W.

Year: 1999

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/387153

Thesis Junk DNA enhances pEI-based non-viral gene delivery

Gaal, E.V.B. van; Oosting, R.S.; Hennink, W.E. et al. · 2010 · Utrecht University · DOI

Full title: Junk DNA enhances pEI-based non-viral gene delivery

Authors: Gaal, E.V.B. van; Oosting, R.S.; Hennink, W.E.; Crommelin, D.J.A.; Mastrobattista, E.

Year: 2010

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/44852

Thesis Mechanistic Model for Production of Recombinant Adeno-associated Virus via Triple Transfection of HEK293 Cells

Nguyen, Tam NT; Sha, Sha; Hong, Moo Sun et al. · 2021 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Mechanistic Model for Production of Recombinant Adeno-associated Virus via Triple Transfection of HEK293 Cells

Authors: Nguyen, Tam NT; Sha, Sha; Hong, Moo Sun; Maloney, Andrew J; Barone, Paul W; Neufeld, Caleb; Wolfrum, Jacqueline; Springs, Stacy L; Sinskey, Anthony J; Braatz, Richard D

Year: 2021

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/135559

Thesis HIV-1 as a Target for the Cas9 DNA Editing Enzyme and the Development of Novel sgRNA Expression Technology

Mefferd, Adam · 2018 · Duke University · DOI

Full title: HIV-1 as a Target for the Cas9 DNA Editing Enzyme and the Development of Novel sgRNA Expression Technology

Authors: Mefferd, Adam

Year: 2018

Venue: Duke University

DOI: https://hdl.handle.net/10161/16949

Thesis Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool

Puarattana-aroonkorn, Sitthiphol; Tharakaraman, Kannan; Suriyawipada, Disapan et al. · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool

Authors: Puarattana-aroonkorn, Sitthiphol; Tharakaraman, Kannan; Suriyawipada, Disapan; Ruchirawat, Mathuros; Fuangthong, Mayuree; Sasisekharan, Ram; Artpradit, Charlermchai

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/155543

Thesis Non-viral Transfection and Direct Reprogramming of Fibroblasts to Neurons and Glia: Importance of Physical and Chemical Microenvironments

Adler, Andrew Frederick · 2014 · Duke University · DOI

Full title: Non-viral Transfection and Direct Reprogramming of Fibroblasts to Neurons and Glia: Importance of Physical and Chemical Microenvironments

Authors: Adler, Andrew Frederick

Year: 2014

Venue: Duke University

DOI: https://hdl.handle.net/10161/9048

Thesis Analysis of charged polymer effects on recombinant retrovirus-mediated gene transfer success

Davis, Howard E. (Howard Elliot), 1973- · 2005 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Analysis of charged polymer effects on recombinant retrovirus-mediated gene transfer success

Authors: Davis, Howard E. (Howard Elliot), 1973-

Year: 2005

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/8350

Thesis Extracellular vesicles: nature's nanoparticles for improving gene transfer with adeno-associated virus vectors

György, B; Maguire, CA · 2025 · University of Basel - edoc Repository · DOI

Full title: Extracellular vesicles: nature's nanoparticles for improving gene transfer with adeno-associated virus vectors

Authors: György, B; Maguire, CA

Year: 2025

Venue: University of Basel - edoc Repository

DOI: https://hdl.handle.net/20.500.14716/58047

Thesis Biocompatible Polymer-Peptide Hybrid-Based DNA Nanoparticles for Gene Delivery

Witzigmann, Dominik; Wu, Dalin; Schenk, Susanne H. et al. · 2025 · University of Basel - edoc Repository · DOI

Full title: Biocompatible Polymer-Peptide Hybrid-Based DNA Nanoparticles for Gene Delivery

Authors: Witzigmann, Dominik; Wu, Dalin; Schenk, Susanne H.; Balasubramanian, Vimalkumar; Meier, Wolfgang P.; Huwyler, Jörg

Year: 2025

Venue: University of Basel - edoc Repository

DOI: http://hdl.handle.net/20.500.14716/42305

Thesis Investigating the Differential Regulation of Cell Surface GAG in Cancer: Using NGPD to Isolate Cancer Cell Specific Peptides

Hardie, Derek T. · 2024 · University of Nottingham · DOI

Full title: Investigating the Differential Regulation of Cell Surface GAG in Cancer: Using NGPD to Isolate Cancer Cell Specific Peptides

Authors: Hardie, Derek T.

Year: 2024

Venue: University of Nottingham

DOI: https://eprints.nottingham.ac.uk/77413/1/Hardie%20Derek%2014342060%20corrections.pdf

Thesis Etablierung der Isolierung, selektiven Anreicherung und Transfektion adulter Schwann-Zellen der Ratte und des Menschen zur Überexpression von FGF-2-Isoformen

Mauritz, Christina · 2005 · University of Veterinary Medicine Hannover (TiHo) · DOI

Full title: Etablierung der Isolierung, selektiven Anreicherung und Transfektion adulter Schwann-Zellen der Ratte und des Menschen zur Überexpression von FGF-2-Isoformen

Authors: Mauritz, Christina

Year: 2005

Venue: University of Veterinary Medicine Hannover (TiHo)

DOI: https://nbn-resolving.org/urn:nbn:de:gbv:95-90575

Thesis Expansion, differentiation and transfection of ventral mesencephalic progenitor cells

Cesnulevicius, Konstantin · 2006 · University of Veterinary Medicine Hannover (TiHo) · DOI

Full title: Expansion, differentiation and transfection of ventral mesencephalic progenitor cells

Authors: Cesnulevicius, Konstantin

Year: 2006

Venue: University of Veterinary Medicine Hannover (TiHo)

DOI: https://nbn-resolving.org/urn:nbn:de:gbv:95-93504

Thesis Improved Methods for Anterograde Axonal Tracing by Viral Vectors

Dogra, Sachi · 2025 · University of California, San Diego (UCSD) · DOI

Full title: Improved Methods for Anterograde Axonal Tracing by Viral Vectors

Authors: Dogra, Sachi

Year: 2025

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/4pj7s913

Thesis Novel Approaches for Pluripotent Reprogramming

Weltner, Jere · 2018 · University of Helsinki (HELDA) · DOI

Full title: Novel Approaches for Pluripotent Reprogramming

Authors: Weltner, Jere

Year: 2018

Venue: University of Helsinki (HELDA)

DOI: http://hdl.handle.net/10138/237188

Thesis Nucleic acid based therapeutic approaches

Joacim Elmén (6729) · 2005 · Karolinska Institutet · DOI

Full title: Nucleic acid based therapeutic approaches

Authors: Joacim Elmén (6729)

Year: 2005

Venue: Karolinska Institutet

DOI: oai:figshare.com:article/26898139

Thesis Transfer of high copy number plasmid into mammalian cells by calcium phosphate transfection

Batard, P.; Jordan, M.; Wurm, F. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transfer of high copy number plasmid into mammalian cells by calcium phosphate transfection

Authors: Batard, P.; Jordan, M.; Wurm, F.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7589

Thesis BMP2 gene delivery mediated by chitosan-ss-PEI non-viral vector and investigation of BMP2 signaling regulation

Zhao, Xiaoli; 赵晓丽 · 2012 · University of Hong Kong · DOI

Full title: BMP2 gene delivery mediated by chitosan-ss-PEI non-viral vector and investigation of BMP2 signaling regulation

Authors: Zhao, Xiaoli; 赵晓丽

Year: 2012

Venue: University of Hong Kong

DOI: https://hub.hku.hk/handle/10722/146135

Thesis Large-scale transient expression in mammalian cells for recombinant protein production

Wurm, F.; Bernard, A. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Large-scale transient expression in mammalian cells for recombinant protein production

Authors: Wurm, F.; Bernard, A.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7633

Thesis Scalable, Serum-free, High Efficiency Transfection of CHO Cells using an Economical DNA Transfer Vehicle

Girard, P.; Derouazi, M.; Wurm, F.M. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Scalable, Serum-free, High Efficiency Transfection of CHO Cells using an Economical DNA Transfer Vehicle

Authors: Girard, P.; Derouazi, M.; Wurm, F.M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7636

Thesis Calfection: a novel gene transfer method for suspension cells

Lindell, J.; Girard, P.; Muller, N. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Calfection: a novel gene transfer method for suspension cells

Authors: Lindell, J.; Girard, P.; Muller, N.; Jordan, M.; Wurm, F.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7624

Thesis Balancing GFP reporter plasmid quantity in large-scale transient transfections for recombinant anti-human Rhesus-D IgG1 synthesis

Pick, H. M.; Meissner, P.; Preuss, A. K. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Balancing GFP reporter plasmid quantity in large-scale transient transfections for recombinant anti-human Rhesus-D IgG1 synthesis

Authors: Pick, H. M.; Meissner, P.; Preuss, A. K.; Tromba, P.; Vogel, H.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7630

Thesis Production of recombinant protein therapeutics in cultivated mammalian cells

Wurm, F. M. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Production of recombinant protein therapeutics in cultivated mammalian cells

Authors: Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7667

Thesis Transient gene expression: recombinant protein production with suspension-adapted HEK293-EBNA cells

Meissner, P.; Pick, H.; Kulangara, A. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transient gene expression: recombinant protein production with suspension-adapted HEK293-EBNA cells

Authors: Meissner, P.; Pick, H.; Kulangara, A.; Chatellard, P.; Friedrich, K.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7617

Thesis Transfection of partially purified plasmid DNA for high level transient protein expression in HEK293-EBNA cells

Wright, J. L.; Jordan, M.; Wurm, F. M. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transfection of partially purified plasmid DNA for high level transient protein expression in HEK293-EBNA cells

Authors: Wright, J. L.; Jordan, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7657

Thesis Serum-free large-scale transient transfection of CHO cells

Derouazi, M.; Girard, P.; Van Tilborgh, F. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Serum-free large-scale transient transfection of CHO cells

Authors: Derouazi, M.; Girard, P.; Van Tilborgh, F.; Iglesias, K.; Muller, N.; Bertschinger, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7662

Thesis Orbital shaker technology for the cultivation of mammalian cells in suspension

Muller, N.; Girard, P.; Hacker, D. L. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Orbital shaker technology for the cultivation of mammalian cells in suspension

Authors: Muller, N.; Girard, P.; Hacker, D. L.; Jordan, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7671

Thesis Transfection using plasmid preparations

Wright, Jason; Wurm, Florian · 2015 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transfection using plasmid preparations

Authors: Wright, Jason; Wurm, Florian

Year: 2015

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/118469

Thesis Transient gene expression in suspension HEK-293 cells: application to large-scale protein production

Baldi, L.; Muller, N.; Picasso, S. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transient gene expression in suspension HEK-293 cells: application to large-scale protein production

Authors: Baldi, L.; Muller, N.; Picasso, S.; Jacquet, R.; Girard, P.; Thanh, H. P.; Derow, E.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7668

Thesis Transfection of adherent and suspended cells by calcium phosphate

Jordan, M.; Wurm, F. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transfection of adherent and suspended cells by calcium phosphate

Authors: Jordan, M.; Wurm, F.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7665

Thesis Caractérisation et optimisation de la production d’adénovirus dans les cellules 293SF en mode perfusion

Dormond, Edwige · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Caractérisation et optimisation de la production d’adénovirus dans les cellules 293SF en mode perfusion

Authors: Dormond, Edwige

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/8587

Thesis Successful Transfection of Partially Purified DNA in the HEK293EBNA Cell Line for Transient Expression

Wright, J.L.; Jordan, M.; Wurm, F.M. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Successful Transfection of Partially Purified DNA in the HEK293EBNA Cell Line for Transient Expression

Authors: Wright, J.L.; Jordan, M.; Wurm, F.M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9730

Thesis Calcium phosphate transfection optimization for serum-free suspension culture

Girard, P.; Porte, L.; Berta, T. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Calcium phosphate transfection optimization for serum-free suspension culture

Authors: Girard, P.; Porte, L.; Berta, T.; Jordan, M.; Wurm, F.M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9728

Thesis Lentiviral-mediated gene transfer to model triplet repeat disorders

Regulier, E.; Zala, D.; Aebischer, P. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Lentiviral-mediated gene transfer to model triplet repeat disorders

Authors: Regulier, E.; Zala, D.; Aebischer, P.; Deglon, N.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/3772

Thesis S-phase synchronized CHO cells show elevated transfection efficiency and expression using Ca/PO4

Grosjean, F.; Batard, P; Jordan, M. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: S-phase synchronized CHO cells show elevated transfection efficiency and expression using Ca/PO4

Authors: Grosjean, F.; Batard, P; Jordan, M.; Wurm, F.M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9734

Thesis 25 years of recombinant proteins from reactor-grown cells — Where do we go from here?

Hacker, David L.; De Jesus, Maria; Wurm, Florian M. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: 25 years of recombinant proteins from reactor-grown cells — Where do we go from here?

Authors: Hacker, David L.; De Jesus, Maria; Wurm, Florian M.

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41353

Thesis Progress in the Use of Adeno-Associated Viral Vectors for Gene Therapy

Büning, Hildegard; Braun-Falco, Markus; Hallek, Michael · 2004 · Technical University of Munich (TUM) · DOI

Full title: Progress in the Use of Adeno-Associated Viral Vectors for Gene Therapy

Authors: Büning, Hildegard;Braun-Falco, Markus;Hallek, Michael

Year: 2004

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1218804

Thesis Magnetic and acoustically active microbubbles loaded with nucleic acids for gene delivery.

Vlaskou, Dialechti; Plank, Christian; Mykhaylyk, Olga · 2013 · Technical University of Munich (TUM) · DOI

Full title: Magnetic and acoustically active microbubbles loaded with nucleic acids for gene delivery.

Authors: Vlaskou, Dialechti;Plank, Christian;Mykhaylyk, Olga

Year: 2013

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1210936

Thesis Poloxamer synperonic F108 improves cellular transduction with lentiviral vectors.

Höfig, I; Atkinson, MJ; Mall, S et al. · 2012 · Technical University of Munich (TUM) · DOI

Full title: Poloxamer synperonic F108 improves cellular transduction with lentiviral vectors.

Authors: Höfig, I;Atkinson, MJ;Mall, S;Krackhardt, AM;Thirion, C;Anastasov, N

Year: 2012

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1181656

Thesis Liposomal magnetofection.

Mykhaylyk, O; Sánchez-Antequera, Y; Vlaskou, D et al. · 2010 · Technical University of Munich (TUM) · DOI

Full title: Liposomal magnetofection.

Authors: Mykhaylyk, O;Sánchez-Antequera, Y;Vlaskou, D;Hammerschmid, E;Anton, M;Zelphati, O;Plank, C

Year: 2010

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1073056

Thesis The magnetofection method: using magnetic force to enhance gene delivery.

Plank, C; Schillinger, U; Scherer, F et al. · 2003 · Technical University of Munich (TUM) · DOI

Full title: The magnetofection method: using magnetic force to enhance gene delivery.

Authors: Plank, C;Schillinger, U;Scherer, F;Bergemann, C;Remy, JS;Krötz, F;Anton, M;Lausier, J;Rosenecker, J

Year: 2003

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1330218

Thesis Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium.

Rudolph, C; Schillinger, U; Ortiz, A et al. · 2005 · Technical University of Munich (TUM) · DOI

Full title: Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium.

Authors: Rudolph, C;Schillinger, U;Ortiz, A;Plank, C;Golas, MM;Sander, B;Stark, H;Rosenecker, J

Year: 2005

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1330338

Thesis Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector.

Merkl, Claudia; Saalfrank, Anja; Riesen, Nathalie et al. · 2013 · Technical University of Munich (TUM) · DOI

Full title: Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector.

Authors: Merkl, Claudia;Saalfrank, Anja;Riesen, Nathalie;Kühn, Ralf;Pertek, Anna;Eser, Stefan;Hardt, Markus Sebastian;Kind, Alexander;Saur, Dieter;Wurst, Wolfgang;Iglesias, Antonio;Schnieke, Angelika

Year: 2013

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1211164

Thesis Magnetofection potentiates gene delivery to cultured endothelial cells.

Krötz, F; Sohn, HY; Gloe, T et al. · 2003 · Technical University of Munich (TUM) · DOI

Full title: Magnetofection potentiates gene delivery to cultured endothelial cells.

Authors: Krötz, F;Sohn, HY;Gloe, T;Plank, C;Pohl, U

Year: 2003

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1330225

Thesis Recombinant adeno-associated virus type 2-mediated gene transfer into human keratinocytes is influenced by both the ubiquitin/proteasome pathway and epidermal growth factor receptor tyrosine kinase.

Braun-Falco, M; Eisenried, A; Büning, H et al. · 2005 · Technical University of Munich (TUM) · DOI

Full title: Recombinant adeno-associated virus type 2-mediated gene transfer into human keratinocytes is influenced by both the ubiquitin/proteasome pathway and epidermal growth factor receptor tyrosine kinase.

Authors: Braun-Falco, M;Eisenried, A;Büning, H;Ring, J

Year: 2005

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1329981

Thesis Nonviral vector loaded collagen sponges for sustained gene delivery in vitro and in vivo.

Scherer, F; Schillinger, U; Putz, U et al. · 2002 · Technical University of Munich (TUM) · DOI

Full title: Nonviral vector loaded collagen sponges for sustained gene delivery in vitro and in vivo.

Authors: Scherer, F;Schillinger, U;Putz, U;Stemberger, A;Plank, C

Year: 2002

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1330194

Thesis Development of an intein-mediated split-Cas9 system for gene therapy.

Truong, Dong-Jiunn Jeffery; Kühner, Karin; Kühn, Ralf et al. · 2015 · Technical University of Munich (TUM) · DOI

Full title: Development of an intein-mediated split-Cas9 system for gene therapy.

Authors: Truong, Dong-Jiunn Jeffery;Kühner, Karin;Kühn, Ralf;Werfel, Stanislas;Engelhardt, Stefan;Wurst, Wolfgang;Ortiz, Oskar

Year: 2015

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1322926

Thesis Nanomagnetic activation as a way to control the efficacy of nucleic acid delivery.

Grze?kowiak, Bartosz F; Sanchez-Antequera, Yolanda; Hammerschmid, Edelburga et al. · 2015 · Technical University of Munich (TUM) · DOI

Full title: Nanomagnetic activation as a way to control the efficacy of nucleic acid delivery.

Authors: Grze?kowiak, Bartosz F;Sanchez-Antequera, Yolanda;Hammerschmid, Edelburga;Döblinger, Markus;Eberbeck, Dietmar;Wo?niak, Anna;S?omski, Ryszard;Plank, Christian;Mykhaylyk, Olga

Year: 2015

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1321595

Thesis Magnetofection Enhances Adenoviral Vector-based Gene Delivery in Skeletal Muscle Cells.

Pereyra, Andrea Soledad; Mykhaylyk, Olga; Lockhart, Eugenia Falomir et al. · 2016 · Technical University of Munich (TUM) · DOI

Full title: Magnetofection Enhances Adenoviral Vector-based Gene Delivery in Skeletal Muscle Cells.

Authors: Pereyra, Andrea Soledad;Mykhaylyk, Olga;Lockhart, Eugenia Falomir;Taylor, Jackson Richard;Delbono, Osvaldo;Goya, Rodolfo Gustavo;Plank, Christian;Hereñu, Claudia Beatriz

Year: 2016

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1362909

Thesis Magnetofection to enhance transfection efficiency of large genomic context vectors in vitro

Xenariou, S; Griesenbach, U; Bowden, R et al. · 2004 · Technical University of Munich (TUM) · DOI

Full title: Magnetofection to enhance transfection efficiency of large genomic context vectors in vitro

Authors: Xenariou, S;Griesenbach, U;Bowden, R;Hillery, E;Doherty, A;Geddes, D;Porteous, D;Plank, C;Alton, E;Boyd, AC

Year: 2004

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1330290

Thesis A novel transfecting peptide comprising a tetrameric nuclear localization sequence.

Ritter, W; Plank, C; Lausier, J et al. · 2003 · Technical University of Munich (TUM) · DOI

Full title: A novel transfecting peptide comprising a tetrameric nuclear localization sequence.

Authors: Ritter, W;Plank, C;Lausier, J;Rudolph, C;Zink, D;Reinhardt, D;Rosenecker, J

Year: 2003

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1330224

Thesis Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells.

Rudolph, C; Plank, C; Lausier, J et al. · 2003 · Technical University of Munich (TUM) · DOI

Full title: Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells.

Authors: Rudolph, C;Plank, C;Lausier, J;Schillinger, U;Müller, RH;Rosenecker, J

Year: 2003

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1330223

Thesis Magnetic nanoparticle and magnetic field assisted siRNA delivery in vitro.

Mykhaylyk, Olga; Sanchez-Antequera, Yolanda; Vlaskou, Dialechti et al. · 2015 · Technical University of Munich (TUM) · DOI

Full title: Magnetic nanoparticle and magnetic field assisted siRNA delivery in vitro.

Authors: Mykhaylyk, Olga;Sanchez-Antequera, Yolanda;Vlaskou, Dialechti;Cerda, Maria Belen;Bokharaei, Mehrdad;Hammerschmid, Edelburga;Anton, Martina;Plank, Christian

Year: 2015

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1321594

Thesis Transferinfection - a Highly Efficient Way to Express Gene Constructs in Eukaryotic Cells

Zatloukal, K.; Wagner, E.; Cotten, M. et al. · 1992 · Technical University of Munich (TUM) · DOI

Full title: Transferinfection - a Highly Efficient Way to Express Gene Constructs in Eukaryotic Cells

Authors: Zatloukal, K. ; Wagner, E. ; Cotten, M. ; Phillips, S. ; Plank, C. ; Steinlein, P. ; Curiel, D. T. ; Birnstiel, M. L.

Year: 1992

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/805553

Thesis Recent advances in magnetofection and its potential to deliver siRNAs in vitro.

Mykhaylyk, O; Zelphati, O; Hammerschmid, E et al. · 2009 · Technical University of Munich (TUM) · DOI

Full title: Recent advances in magnetofection and its potential to deliver siRNAs in vitro.

Authors: Mykhaylyk, O;Zelphati, O;Hammerschmid, E;Anton, M;Rosenecker, J;Plank, C

Year: 2009

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/824242

Thesis Generation of magnetic nonviral gene transfer agents and magnetofection in vitro.

Mykhaylyk, O; Antequera, YS; Vlaskou, D et al. · 2007 · Technical University of Munich (TUM) · DOI

Full title: Generation of magnetic nonviral gene transfer agents and magnetofection in vitro.

Authors: Mykhaylyk, O;Antequera, YS;Vlaskou, D;Plank, C

Year: 2007

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/674887

Thesis A fibrin glue composition as carrier for nucleic acid vectors.

Schillinger, U; Wexel, G; Hacker, C et al. · 2008 · Technical University of Munich (TUM) · DOI

Full title: A fibrin glue composition as carrier for nucleic acid vectors.

Authors: Schillinger, U;Wexel, G;Hacker, C;Kullmer, M;Koch, C;Gerg, M;Vogt, S;Ueblacker, P;Tischer, T;Hensler, D;Wilisch, J;Aigner, J;Walch, A;Stemberger, A;Plank, C

Year: 2008

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/693762

Thesis Optimized Lentiviral Transduction Protocols by Use of a Poloxamer Enhancer, Spinoculation, and scFv-Antibody Fusions to VSV-G.

Anastasov, Nata?a; Höfig, Ines; Mall, Sabine et al. · 2016 · Technical University of Munich (TUM) · DOI

Full title: Optimized Lentiviral Transduction Protocols by Use of a Poloxamer Enhancer, Spinoculation, and scFv-Antibody Fusions to VSV-G.

Authors: Anastasov, Nata?a;Höfig, Ines;Mall, Sabine;Krackhardt, Angela M;Thirion, Christian

Year: 2016

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1360687

Thesis High Efficiency Low Cost Fibroblast Nucleofection for GMP Compatible Cell-based Gene Therapy.

Zhang, Ziyang; Slobodianski, Alex; Arnold, Astrid et al. · 2017 · Technical University of Munich (TUM) · DOI

Full title: High Efficiency Low Cost Fibroblast Nucleofection for GMP Compatible Cell-based Gene Therapy.

Authors: Zhang, Ziyang;Slobodianski, Alex;Arnold, Astrid;Nehlsen, Jessica;Hopfner, Ursula;Schilling, Arndt F;Perisic, Tatjana;Machens, Hans-Günther

Year: 2017

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1435929

Thesis High Throughput Screening for the Enhancement of Adeno-Associated Virus Type 2 Transduction

Wallen, Alexis J · 2023 · University of Pennsylvania · DOI

Full title: High Throughput Screening for the Enhancement of Adeno-Associated Virus Type 2 Transduction

Authors: Wallen, Alexis J

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/30848

Thesis ESTABLISHMENT AND UTILIZATION OF DUAL-COLOR REPORTER MODELS FOR IMPROVING GENE THERAPY AND GENE EDITING STRATEGIES

Weber, Jesse, Andrew · 2024 · University of Pennsylvania · DOI

Full title: ESTABLISHMENT AND UTILIZATION OF DUAL-COLOR REPORTER MODELS FOR IMPROVING GENE THERAPY AND GENE EDITING STRATEGIES

Authors: Weber, Jesse, Andrew

Year: 2024

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/60101

Thesis Evaluation of Adeno-Associated Viral Vectors for Liver-Directed Gene Transfer in Dogs

Bell, Peter; Haskins, Mark E; Gao, Guangping et al. · 2023 · University of Pennsylvania · DOI

Full title: Evaluation of Adeno-Associated Viral Vectors for Liver-Directed Gene Transfer in Dogs

Authors: Bell, Peter; Haskins, Mark E; Gao, Guangping; Sleeper, Margaret M; Wang, Lili; Wang, Huan; Calcedo, Roberto; Vandenberghe, Luk H; Chen, Shu-Jen; Weisse, Chick; Withnall, Elanor; Wilson, James M

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/48978

Thesis Development of pooled perturbation approaches for neurodegenerative phenotypes and therapeutic strategies

O'Driscoll, Emily, Elizabeth · 2025 · University of Pennsylvania · DOI

Full title: Development of pooled perturbation approaches for neurodegenerative phenotypes and therapeutic strategies

Authors: O'Driscoll, Emily, Elizabeth

Year: 2025

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/61270

Thesis Enhancement of lentiviral vector production through alteration of virus-cell interactions

Gelinas, J · 2016 · University of Oxford - ORA · DOI

Full title: Enhancement of lentiviral vector production through alteration of virus-cell interactions

Authors: Gelinas, J

Year: 2016

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:9921b8b4-e2b5-4eec-9efc-6036765c8d55

Thesis Lentiviral delivery of CRISPR Cas9 prime editing system for cystic fibrosis

Satyapertiwi, D · 2024 · University of Oxford - ORA · DOI

Full title: Lentiviral delivery of CRISPR Cas9 prime editing system for cystic fibrosis

Authors: Satyapertiwi, D

Year: 2024

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:65e46bd6-d43b-440f-b906-1ec4323337ae

Thesis Strategies to facilitate the long-term expression of transgenes for treatment of chronic liver disease

van Haasteren, J · 2019 · University of Oxford - ORA · DOI

Full title: Strategies to facilitate the long-term expression of transgenes for treatment of chronic liver disease

Authors: van Haasteren, J

Year: 2019

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:89545b9b-6ed5-4a78-9232-c0a645d7ee67

Thesis Optogenetic gene therapy for vision restoration

Hickey, D · 2015 · University of Oxford - ORA · DOI

Full title: Optogenetic gene therapy for vision restoration

Authors: Hickey, D

Year: 2015

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:820a45d5-60db-4c01-808a-8a3720c48f2c

Thesis Unravelling the essential elements for recombinant adeno-associated virus (rAAV) production in animal cell-based platforms

Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Tzimou, Konstantina et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Unravelling the essential elements for recombinant adeno-associated virus (rAAV) production in animal cell-based platforms

Authors: Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Tzimou, Konstantina; Nielsen, Lars K.; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/00e28410-d986-4a71-bcb4-7e64bcd223a2

Thesis Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Hansen, Henning Gram; Nilsson, Claes Nymand; Lund, Anne Mathilde et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Authors: Hansen, Henning Gram; Nilsson, Claes Nymand; Lund, Anne Mathilde; Kol, Stefan; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lundqvist, Magnus; Rockberg, Johan; Min Lee, Gyun; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/41719bc3-f624-40be-ba5e-4449c22aac7f

Thesis Epizone: Interlaboratory Ring Trial to Compare Dna Transfection Efficiencies

Dory, Daniel; Albina, Emmanuel; Kwiatek, Olivier et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: Epizone: Interlaboratory Ring Trial to Compare Dna Transfection Efficiencies

Authors: Dory, Daniel; Albina, Emmanuel; Kwiatek, Olivier; Keil, Guenther; Finke, Stefan; Fuchs, Walter; Kluup, Barbara; König, Patricia; Dixon, Linda; Goatley, Lynnette; Takamatsu, Haru; Borrego, Belen; Brun, Alejandro; Ortego, Javier; Friis, Martin Barfred; Lorenzen, Niels; id_orcid 0000-0002-6946-3252; Rasmussen, Thomas Bruun; Schyth, Brian Dall; Crooke, Helen; Sosan, Olbukola

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/13cec1b4-21dc-400d-8868-fdb9a9a75c2e

Thesis Development of AAV-mediated gene therapy for autosomal recessive bestrophinopathy

Wood, S · 2017 · University of Oxford - ORA · DOI

Full title: Development of AAV-mediated gene therapy for autosomal recessive bestrophinopathy

Authors: Wood, S

Year: 2017

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:e0925bc0-8f36-4a76-9366-bc7dc316c5af

Thesis Targeted knockdown of ATM, ATR, and PDEδ increases Gag HIV-1 VLP production in HEK293 cells

Díaz-Maneh, Andy; Pérez-Rubio, Pol; Granes, Cristina Rigau et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Targeted knockdown of ATM, ATR, and PDEδ increases Gag HIV-1 VLP production in HEK293 cells

Authors: Díaz-Maneh, Andy; Pérez-Rubio, Pol; Granes, Cristina Rigau; Bosch-Molist, Laia; Lavado-García, Jesús; Gòdia, Francesc; Cervera, Laura

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/45e24517-ea8b-44f2-a6c2-ae6c443775a8

Thesis Development of a self-silencing adenovirus for the efficient manufacture of adeno-associated virus vectors

Su, W · 2021 · University of Oxford - ORA · DOI

Full title: Development of a self-silencing adenovirus for the efficient manufacture of adeno-associated virus vectors

Authors: Su, W

Year: 2021

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:bf702b24-b539-4255-81fa-0b94da36d363

Thesis Systematic insights into cell density-dependent transcriptional responses upon medium replacements

Pérez-Rubio, Pol; Romero, Elianet Lorenzo; Cervera, Laura et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Systematic insights into cell density-dependent transcriptional responses upon medium replacements

Authors: Pérez-Rubio, Pol; Romero, Elianet Lorenzo; Cervera, Laura; Gòdia, Francesc; Nielsen, Lars Keld; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2c104764-6292-43ba-8eaf-c03af53bbcf2

Thesis Minicircle DNA-mediated endothelial nitric oxide synthase gene transfer enhances angiogenic responses of bone marrow-derived mesenchymal stem cells

Bandara, Nadeeka; Gurusinghe, Saliya; id_orcid 0000-0001-5779-3468 et al. · 2016 · Charles Sturt University - Research Output · DOI

Full title: Minicircle DNA-mediated endothelial nitric oxide synthase gene transfer enhances angiogenic responses of bone marrow-derived mesenchymal stem cells

Authors: Bandara, Nadeeka; Gurusinghe, Saliya; id_orcid 0000-0001-5779-3468; Chen, Haiying; Chen, Shuangfeng; Wang, Le-xin; Lim, Shiang Y.; Strappe, Padraig

Year: 2016

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/2145c668-9a85-476f-ad9f-0ad11c4bcb60

Thesis A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

Lund, Anne Mathilde; Kildegaard, Helene Faustrup; Petersen, Maja Borup Kjær et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

Authors: Lund, Anne Mathilde; Kildegaard, Helene Faustrup; Petersen, Maja Borup Kjær; Rank, Julie; Hansen, Bjarne Gram; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Mortensen, Uffe Hasbro; id_orcid 0000-0002-7794-7273

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1e6b9cdd-536a-420a-b808-622781069950

Thesis Unravelling the essential elements for recombinant adeno-associated virus (rAAV) production in animal cell-based platforms

Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Tzimou, Konstantina et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Unravelling the essential elements for recombinant adeno-associated virus (rAAV) production in animal cell-based platforms

Authors: Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Tzimou, Konstantina; Nielsen, Lars K.; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/00e28410-d986-4a71-bcb4-7e64bcd223a2

Thesis Minicircle mediated gene delivery to canine and equine mesenchymal stem cells

Tidd, Naomie; Michelsen, Jacob; Hilbert, Bryan et al. · 2017 · Charles Sturt University - Research Output · DOI

Full title: Minicircle mediated gene delivery to canine and equine mesenchymal stem cells

Authors: Tidd, Naomie; Michelsen, Jacob; Hilbert, Bryan; Quinn, Jane C.; id_orcid 0000-0002-9310-0291

Year: 2017

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/90e70eeb-5b16-4ca1-b136-aa86be060343

Thesis Internalization of PEI-based complexes in transient transfection of HEK293 cells is triggered by coalescence of membrane heparan sulfate proteoglycans like Glypican-4

Pérez-Rubio, Pol; Vendrell-Flotats, Meritxell; Romero, Elianet Lorenzo et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Internalization of PEI-based complexes in transient transfection of HEK293 cells is triggered by coalescence of membrane heparan sulfate proteoglycans like Glypican-4

Authors: Pérez-Rubio, Pol; Vendrell-Flotats, Meritxell; Romero, Elianet Lorenzo; Enemark-Rasmussen, Kasper; id_orcid 0000-0001-7455-7512; Cervera, Laura; Gòdia, Francesc; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/6367220f-a1a7-48e0-9fec-42d38dbb1694

Thesis Evolution from adherent to suspension: systems biology of HEK293 cell line development

Malm, Magdalena; Saghaleyni, Rasool; Lundqvist, Magnus et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Evolution from adherent to suspension: systems biology of HEK293 cell line development

Authors: Malm, Magdalena; Saghaleyni, Rasool; Lundqvist, Magnus; Giudici, Marco; Chotteau, Veronique; Field, Ray; Varley, Paul G.; Hatton, Diane; Grassi, Luigi; Svensson, Thomas; Nielsen, Jens; Rockberg, Johan

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ac719809-b95e-40e0-85c8-5c0a28c5bd85

Thesis Navigating biomanufacturing challenges in the use of CHO cells for recombinant adeno-associated virus production

Tatjer, David Catalán; id_orcid 0000-0002-0900-9912 · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Navigating biomanufacturing challenges in the use of CHO cells for recombinant adeno-associated virus production

Authors: Tatjer, David Catalán; id_orcid 0000-0002-0900-9912

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9209d5ce-66e5-452d-9d20-a94da77a0102

Thesis Unlocking DOE potential by selecting the most appropriate design for rAAV optimization

Tzimou, Konstantina; Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Unlocking DOE potential by selecting the most appropriate design for rAAV optimization

Authors: Tzimou, Konstantina; Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Nielsen, Lars K.; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bcce91f5-d977-47e8-a623-e02bd6425a16

Thesis Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Hansen, Henning Gram; Nilsson, Claes Nymand; Lund, Anne Mathilde et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/41719bc3-f624-40be-ba5e-4449c22aac7f

Thesis Systematic insights into cell density-dependent transcriptional responses upon medium replacements

Pérez-Rubio, Pol; Romero, Elianet Lorenzo; Cervera, Laura et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Systematic insights into cell density-dependent transcriptional responses upon medium replacements

Authors: Pérez-Rubio, Pol; Romero, Elianet Lorenzo; Cervera, Laura; Gòdia, Francesc; Nielsen, Lars Keld; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2c104764-6292-43ba-8eaf-c03af53bbcf2

Thesis Purification of adenovirus and adeno-associated virus:Comparison of novel membrane-based technology to conventional techniques

Duffy, A.M.; O'Doherty, A.M.; O'Brien, T. et al. · 2005 · Charles Sturt University - Research Output · DOI

Full title: Purification of adenovirus and adeno-associated virus:Comparison of novel membrane-based technology to conventional techniques

Authors: Duffy, A.M.; O'Doherty, A.M.; O'Brien, T.; Strappe, P.M.

Year: 2005

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/11730150-8234-4f79-8f8d-a76b331551fe

Thesis Internalization of PEI-based complexes in transient transfection of HEK293 cells is triggered by coalescence of membrane heparan sulfate proteoglycans like Glypican-4

Pérez-Rubio, Pol; Vendrell-Flotats, Meritxell; Romero, Elianet Lorenzo et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Internalization of PEI-based complexes in transient transfection of HEK293 cells is triggered by coalescence of membrane heparan sulfate proteoglycans like Glypican-4

Authors: Pérez-Rubio, Pol; Vendrell-Flotats, Meritxell; Romero, Elianet Lorenzo; Enemark-Rasmussen, Kasper; id_orcid 0000-0001-7455-7512; Cervera, Laura; Gòdia, Francesc; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/6367220f-a1a7-48e0-9fec-42d38dbb1694

Thesis Epizone: Interlaboratory Ring Trial to Compare Dna Transfection Efficiencies

Dory, Daniel; Albina, Emmanuel; Kwiatek, Olivier et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: Epizone: Interlaboratory Ring Trial to Compare Dna Transfection Efficiencies

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/13cec1b4-21dc-400d-8868-fdb9a9a75c2e

Thesis Minicircle DNA-mediated endothelial nitric oxide synthase gene transfer enhances angiogenic responses of bone marrow-derived mesenchymal stem cells

Bandara, Nadeeka; Gurusinghe, Saliya; id_orcid 0000-0001-5779-3468 et al. · 2016 · Charles Sturt University - Research Output · DOI

Full title: Minicircle DNA-mediated endothelial nitric oxide synthase gene transfer enhances angiogenic responses of bone marrow-derived mesenchymal stem cells

Authors: Bandara, Nadeeka; Gurusinghe, Saliya; id_orcid 0000-0001-5779-3468; Chen, Haiying; Chen, Shuangfeng; Wang, Le-xin; Lim, Shiang Y.; Strappe, Padraig

Year: 2016

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/2145c668-9a85-476f-ad9f-0ad11c4bcb60

Thesis Gene transfer into rat mesenchymal stem cells:A comparative study of viral and nonviral vectors

McMahon, J.M.; Conroy, S; Lyons, M et al. · 2006 · Charles Sturt University - Research Output · DOI

Full title: Gene transfer into rat mesenchymal stem cells:A comparative study of viral and nonviral vectors

Authors: McMahon, J.M.; Conroy, S; Lyons, M; Greiser, U; O'Shea, C; Strappe, P; Howard, L; Murphy, M; Barry, F; O'Brien, T

Year: 2006

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/038095fe-fe5d-4031-8977-e555dc3fb424

Thesis A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

Lund, Anne Mathilde; Kildegaard, Helene Faustrup; Petersen, Maja Borup Kjær et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1e6b9cdd-536a-420a-b808-622781069950

Thesis Impact of chemically defined culture media formulations on extracellular vesicle production by amniotic epithelial cells

Zhu, Dandan; Fang, Haoyun; Kusuma, Gina D et al. · 2021 · Charles Sturt University - Research Output · DOI

Full title: Impact of chemically defined culture media formulations on extracellular vesicle production by amniotic epithelial cells

Authors: Zhu, Dandan; Fang, Haoyun; Kusuma, Gina D; Schwab, Renate; id_orcid 0000-0002-5551-1700; Barabadi, Mehri; Chan, Siow Teng; McDonald, Hannah; Leong, Cheng Mee; Wallace, Euan M; Greening, David W; Lim, Rebecca

Year: 2021

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/86052785-ab5c-49b1-8757-2089472b3a36

Thesis Targeted knockdown of ATM, ATR, and PDEδ increases Gag HIV-1 VLP production in HEK293 cells

Díaz-Maneh, Andy; Pérez-Rubio, Pol; Granes, Cristina Rigau et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Targeted knockdown of ATM, ATR, and PDEδ increases Gag HIV-1 VLP production in HEK293 cells

Authors: Díaz-Maneh, Andy; Pérez-Rubio, Pol; Granes, Cristina Rigau; Bosch-Molist, Laia; Lavado-García, Jesús; Gòdia, Francesc; Cervera, Laura

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/45e24517-ea8b-44f2-a6c2-ae6c443775a8

Thesis Lactate as an indicator of terminating time in insect cell culture baculovirus expression vector systems

Clausen, A.; Svendsen, I.; Emborg, Claus · 1996 · Technical University of Denmark (DTU) · DOI

Full title: Lactate as an indicator of terminating time in insect cell culture baculovirus expression vector systems

Authors: Clausen, A.; Svendsen, I.; Emborg, Claus

Year: 1996

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/14208bd4-3bb6-4bbd-8240-bad3fc16ec3a

Thesis Technical challenges in the development of reverse genetics for a viral haemorrhagic septicaemia virus (VHSV) genotype Ib isolate: Alternative cell lines and general troubleshooting

Farias Alencar, Anna Luiza; id_orcid 0000-0002-4864-9111; Cuenca, Argelia et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Technical challenges in the development of reverse genetics for a viral haemorrhagic septicaemia virus (VHSV) genotype Ib isolate: Alternative cell lines and general troubleshooting

Authors: Farias Alencar, Anna Luiza; id_orcid 0000-0002-4864-9111; Cuenca, Argelia; id_orcid 0000-0001-8596-1086; Olesen, Niels Jørgen; id_orcid 0000-0002-0152-4135; Rasmussen, Thomas Bruun

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/6a3771ad-d0db-459b-820a-828e706376b5

Thesis Modified microplex vector enhances transfection of cells in culture while maintaining tumor-selective gene delivery in-vivo

Dass, Crispin; Burton, Mark · 2003 · Charles Sturt University - Research Output · DOI

Full title: Modified microplex vector enhances transfection of cells in culture while maintaining tumor-selective gene delivery in-vivo

Authors: Dass, Crispin; Burton, Mark

Year: 2003

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/5c5a51a3-a5ab-4f96-af54-cc662756e59f

Thesis Large-Scale mRNA Transfection of Dendritic Cells by Electroporation in Continuous Flow Systems

Selmeczi, Dávid; Hansen, Thomas Steen; Met, Özcan et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Large-Scale mRNA Transfection of Dendritic Cells by Electroporation in Continuous Flow Systems

Authors: Selmeczi, Dávid; Hansen, Thomas Steen; Met, Özcan; Svane, Inge Marie; Larsen, Niels Bent; id_orcid 0000-0001-6506-3991

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/48539b2c-01af-4cff-baa9-38f7cbdfdf40

Thesis Evolution from adherent to suspension: systems biology of HEK293 cell line development

Malm, Magdalena; Saghaleyni, Rasool; Lundqvist, Magnus et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Evolution from adherent to suspension: systems biology of HEK293 cell line development

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ac719809-b95e-40e0-85c8-5c0a28c5bd85

Thesis Delivery of a lentiviral vector in a Pluronic F127 gel to cells of the central nervous system

Strappe, Padraig M.; Hampton, David W.; Cachon-Gonzalez, Begona et al. · 2005 · Charles Sturt University - Research Output · DOI

Full title: Delivery of a lentiviral vector in a Pluronic F127 gel to cells of the central nervous system

Authors: Strappe, Padraig M.; Hampton, David W.; Cachon-Gonzalez, Begona; Fawcett, James W.; Lever, Andrew

Year: 2005

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/47fce20e-a1b4-4773-b2da-49fa6d4dc0b0

Thesis Navigating biomanufacturing challenges in the use of CHO cells for recombinant adeno-associated virus production

Tatjer, David Catalán; id_orcid 0000-0002-0900-9912 · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Navigating biomanufacturing challenges in the use of CHO cells for recombinant adeno-associated virus production

Authors: Tatjer, David Catalán; id_orcid 0000-0002-0900-9912

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9209d5ce-66e5-452d-9d20-a94da77a0102

Thesis Minicircle mediated gene delivery to canine and equine mesenchymal stem cells

Tidd, Naomie; Michelsen, Jacob; Hilbert, Bryan et al. · 2017 · Charles Sturt University - Research Output · DOI

Full title: Minicircle mediated gene delivery to canine and equine mesenchymal stem cells

Authors: Tidd, Naomie; Michelsen, Jacob; Hilbert, Bryan; Quinn, Jane C.; id_orcid 0000-0002-9310-0291

Year: 2017

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/90e70eeb-5b16-4ca1-b136-aa86be060343

Thesis Combinatorial treatment with lithium chloride enhances recombinant antibody production in transiently transfected CHO and HEK293E cells

Kim, Che Lin; Kwang Ha, Tae; Min Lee, Gyun · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Combinatorial treatment with lithium chloride enhances recombinant antibody production in transiently transfected CHO and HEK293E cells

Authors: Kim, Che Lin; Kwang Ha, Tae; Min Lee, Gyun

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/01b5ec11-ab2c-410e-8ab0-629bf31319da

Thesis Unlocking DOE potential by selecting the most appropriate design for rAAV optimization

Tzimou, Konstantina; Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Unlocking DOE potential by selecting the most appropriate design for rAAV optimization

Authors: Tzimou, Konstantina; Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Nielsen, Lars K.; Lavado-García, Jesús

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bcce91f5-d977-47e8-a623-e02bd6425a16

Thesis Optimizing hyaluronidase dose and plasmid DNA delivery greatly improves gene electrotransfer efficiency in rat skeletal muscle

Åkerström, Thorbjörn; Vedel, Kenneth; Needham Andersen, Josefine et al. · 2015 · University of Copenhagen · DOI

Full title: Optimizing hyaluronidase dose and plasmid DNA delivery greatly improves gene electrotransfer efficiency in rat skeletal muscle

Authors: Åkerström, Thorbjörn; Vedel, Kenneth; Needham Andersen, Josefine; Hojman, Pernille; Kontou, Eftychia; Hellsten, Ylva; Wojtaszewski, Jørgen

Year: 2015

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/f0d31302-4e31-48c0-88e9-a1143b122486

Thesis Efficient transduction of equine adipose-derived mesenchymal stem cells by VSV-G pseudotyped lentiviral vectors

Petersen, Gayle; Hilbert, Bryan; Trope, Gareth et al. · 2014 · Charles Sturt University - Research Output · DOI

Full title: Efficient transduction of equine adipose-derived mesenchymal stem cells by VSV-G pseudotyped lentiviral vectors

Authors: Petersen, Gayle; Hilbert, Bryan; Trope, Gareth; Kalle, Wouter; Strappe, Padraig

Year: 2014

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/9869d18a-73ab-4ebc-94dc-1a551979ee18

Thesis Comparative evaluation of viral, nonviral and physical methods of gene delivery to normal and transformed lung epithelial cells

Gilbert, Jennifer L.; Purcell, James; Strappe, Padraig et al. · 2008 · Charles Sturt University - Research Output · DOI

Full title: Comparative evaluation of viral, nonviral and physical methods of gene delivery to normal and transformed lung epithelial cells

Authors: Gilbert, Jennifer L.; Purcell, James; Strappe, Padraig; McCabe, Matthew; OBrien, Timothy; ODea, Shirley

Year: 2008

Venue: Charles Sturt University - Research Output

DOI: https://researchoutput.csu.edu.au/en/publications/bbce1bd8-03fe-45db-931f-17a027168735

Thesis Transient expression of rabies virus G-glycoprotein using BHK-21 cells cultured in suspension

Nuñez, Eutimio Gustavo Fernández [UNESP]; De Rezende, Alexandre GonÇalves; Puglia, Ana Lia Pradella et al. · 2015 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Transient expression of rabies virus G-glycoprotein using BHK-21 cells cultured in suspension

Authors: Nuñez, Eutimio Gustavo Fernández [UNESP]; De Rezende, Alexandre GonÇalves; Puglia, Ana Lia Pradella; Leme, Jaci; Boldorini, Vera Lucia Lopes; Caricati, Celso Pereira; Tonso, Aldo

Year: 2015

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://link.springer.com/article/10.1007%2Fs10529-015-1787-3

Thesis Transfection of primary brain capillary endothelial cells for protein synthesis and secretion of recombinant erythropoietin: a strategy to enable protein delivery to the brain

Burkhart, Annette; Andresen, Thomas Lars; id_orcid 0000-0002-1048-127X et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Transfection of primary brain capillary endothelial cells for protein synthesis and secretion of recombinant erythropoietin: a strategy to enable protein delivery to the brain

Authors: Burkhart, Annette; Andresen, Thomas Lars; id_orcid 0000-0002-1048-127X; Aigner, Achim; Thomsen, Louiza Bohn; Moos, Torben

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ea34253f-c646-4f1a-a9ac-cd8769c8bb27

Thesis The impact of physical and biological factors on intracellular uptake, trafficking and gene transfection after ultrasound exposure

Liu, Ying · 2012 · Georgia Institute of Technology · DOI

Full title: The impact of physical and biological factors on intracellular uptake, trafficking and gene transfection after ultrasound exposure

Authors: Liu, Ying

Year: 2012

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/43626

Thesis Rekombinante Adeno-assoziierte Viren zur Expression des µ-Opioid-Rezeptors in neuronalen Zellen

Abbarin, Mehrnousch · 2010 · Freie Universität Berlin (Refubium) · DOI

Full title: Rekombinante Adeno-assoziierte Viren zur Expression des µ-Opioid-Rezeptors in neuronalen Zellen

Authors: Abbarin, Mehrnousch

Year: 2010

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/7311

Thesis A systematic study of transfection efficiency and cytotoxicity in HeLa cells using iron oxide nanoparticles prepared with organic and inorganic bases

Calmon, Marilia de Freitas [UNESP]; de Souza, Aryane Tofanello [UNESP]; Candido, Natalia Maria [UNESP] et al. · 2014 · Universidade Estadual Paulista (UNESP) · DOI

Full title: A systematic study of transfection efficiency and cytotoxicity in HeLa cells using iron oxide nanoparticles prepared with organic and inorganic bases

Authors: Calmon, Marilia de Freitas [UNESP]; de Souza, Aryane Tofanello [UNESP]; Candido, Natalia Maria [UNESP]; Bartolomeu Raposo, Maria Irene; Taboga, Sebastiao [UNESP]; Rahal, Paula [UNESP]; Nery, Jose G. [UNESP]

Year: 2014

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1016/j.colsurfb.2012.05.026

Thesis Integration pattern of HIV-1 based lentiviral vector carrying recombinant coagulation factor VIII in Sk-Hep and 293T cells

Covas, Dimas Tadeu · 2011 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Integration pattern of HIV-1 based lentiviral vector carrying recombinant coagulation factor VIII in Sk-Hep and 293T cells

Authors: Covas, Dimas Tadeu

Year: 2011

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.1007/s10529-010-0387-5

Thesis Optimization of a process for high-yield lentiviral vector production applied to car-t cell generation

Souza, Lucas Eduardo Botelho de · 2020 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Optimization of a process for high-yield lentiviral vector production applied to car-t cell generation

Authors: Souza, Lucas Eduardo Botelho de

Year: 2020

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.1016/j.htct.2020.10.709

Thesis GENE THERAPY FOR GYRATE ATROPHY OF CHOROID AND RETINA AND FOR USH1B RETINITIS PIGMENTOSA

DELL'AQUILA, FABIO · 2021 · Università degli Studi di Milano (AIR) · DOI

Full title: GENE THERAPY FOR GYRATE ATROPHY OF CHOROID AND RETINA AND FOR USH1B RETINITIS PIGMENTOSA

Authors: DELL'AQUILA, FABIO

Year: 2021

Venue: Università degli Studi di Milano (AIR)

DOI: http://hdl.handle.net/2434/884458

Thesis Gene therapy using viral vector against anxiety

Loo, Sze Jie · 2016 · Nanyang Technological University (NTU) · DOI

Full title: Gene therapy using viral vector against anxiety

Authors: Loo, Sze Jie

Year: 2016

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/67358

Thesis Engineering whole-body gene therapies for aging

Florea, Michael · 2023 · Harvard University - DASH · DOI

Full title: Engineering whole-body gene therapies for aging

Authors: Florea, Michael

Year: 2023

Venue: Harvard University - DASH

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37375576

Thesis Optimal delivery of therapeutic genes to pancreatic islets.

Hughes, Amy · 2013 · University of Adelaide · DOI

Full title: Optimal delivery of therapeutic genes to pancreatic islets.

Authors: Hughes, Amy

Year: 2013

Venue: University of Adelaide

DOI: http://hdl.handle.net/2440/81571

Thesis Viral Vectors for Gene Therapy, Cancer, and SARS-CoV-2

Dagotto, Gabriel · 2024 · Harvard University - DASH · DOI

Full title: Viral Vectors for Gene Therapy, Cancer, and SARS-CoV-2

Authors: Dagotto, Gabriel

Year: 2024

Venue: Harvard University - DASH

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37378755

Thesis The development of HIV-1 derived gene transfer technology: optimisation of vector safety, processing and production.

Koldej, Rachel Marie · 2008 · University of Adelaide · DOI

Full title: The development of HIV-1 derived gene transfer technology: optimisation of vector safety, processing and production.

Authors: Koldej, Rachel Marie

Year: 2008

Venue: University of Adelaide

DOI: http://hdl.handle.net/2440/42907

Thesis Capsule-like safe genetic vectors — cell-penetrating core – shell particles selectively release functional small RNA and entrap its encoding DNA

Yu, Han; Pan, Matthew Houwen; Evalin et al. · 2020 · Nanyang Technological University (NTU) · DOI

Full title: Capsule-like safe genetic vectors — cell-penetrating core – shell particles selectively release functional small RNA and entrap its encoding DNA

Authors: Yu, Han; Pan, Matthew Houwen; Evalin; Trau, Dieter; Patzel, Volker

Year: 2020

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/141342

Thesis Establishing an in-house lentiviral vector platform and associated analytics

Toh, Xavier Yi Quan · 2025 · Nanyang Technological University (NTU) · DOI

Full title: Establishing an in-house lentiviral vector platform and associated analytics

Authors: Toh, Xavier Yi Quan

Year: 2025

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/184350

Thesis Overexpression of RasV12 and its role in promoting the robustness of HEK293T cells.

Chow, Peiyi Vicki. · 2013 · Nanyang Technological University (NTU) · DOI

Full title: Overexpression of RasV12 and its role in promoting the robustness of HEK293T cells.

Authors: Chow, Peiyi Vicki.

Year: 2013

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/52745

Thesis Optimization of chemically defined cell culture media: Replacing fetal bovine serum in mammalian in vitro methods

van der Valk, J.B.F.; Brunner, D.; De Smet, K. et al. · 2010 · Utrecht University · DOI

Full title: Optimization of chemically defined cell culture media: Replacing fetal bovine serum in mammalian in vitro methods

Authors: van der Valk, J.B.F.; Brunner, D.; De Smet, K.; Fex Svenningsen, Å.; Honegger, P.; Knudsen, L.E.; Lindl, T.; Noraberg, J.; Price, A.; Scarino, M.L.; Gstraunthaler, G.

Year: 2010

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/191398

Thesis 100-liter transient transfection

Girard, P; Derouazi, M; Baumgartner, G et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: 100-liter transient transfection

Authors: Girard, P; Derouazi, M; Baumgartner, G; Bourgeois, M; Jordan, M; Jacko, B; Wurm, FM

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41396

Thesis Application of pulsed-magnetic field enhances non-viral gene delivery in primary cells from different origins

Kamau Chapman, Sarah W.; Hassa, Paul O.; Koch-Schneidemann, Sabine et al. · 2008 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Application of pulsed-magnetic field enhances non-viral gene delivery in primary cells from different origins

Authors: Kamau Chapman, Sarah W.; Hassa, Paul O.; Koch-Schneidemann, Sabine; von Rechenberg, Brigitte; Hofmann-Amtenbrink, Margarethe; Steitz, Benedikt; Petri-Fink, Alke; Hofmann, Heinrich; Hottiger, Michael O.

Year: 2008

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/17215

Thesis Coexpression of acidic fibroblast growth factor enhances specific productivity and antibody titers in transiently transfected HEK293 cells

Backliwal, G; Hildinger, M; Chenuet, S et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Coexpression of acidic fibroblast growth factor enhances specific productivity and antibody titers in transiently transfected HEK293 cells

Authors: Backliwal, G; Hildinger, M; Chenuet, S; Dejesus, M; Wurm, FM

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41397

Thesis Low-temperature pausing of cultivated mammalian cells

Hunt, L.; Hacker, D. L.; Grosjean, F. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Low-temperature pausing of cultivated mammalian cells

Authors: Hunt, L.; Hacker, D. L.; Grosjean, F.; De Jesus, M.; Uebersax, L.; Jordan, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9752

Thesis Development of high-titer transient gene expression processes for manufacturing recombinant proteins

Backliwal, Gaurav · 2008 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Development of high-titer transient gene expression processes for manufacturing recombinant proteins

Authors: Backliwal, Gaurav

Year: 2008

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/26414

Thesis S-phase synchronized CHO cells show elevated transfection efficiency and expression using CaPi

Grosjean, F; Batard, P; Jordan, M et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: S-phase synchronized CHO cells show elevated transfection efficiency and expression using CaPi

Authors: Grosjean, F; Batard, P; Jordan, M; Wurm, FM

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41385

Thesis Calcium phosphate transfection generates mammalian recombinant cell lines with higher specific productivity than polyfection

Chenuet, S; Martinet, D; Besuchet-Schmutz, N et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Calcium phosphate transfection generates mammalian recombinant cell lines with higher specific productivity than polyfection

Authors: Chenuet, S; Martinet, D; Besuchet-Schmutz, N; Wicht, M; Jaccard, N; Bon, AC; Derouazi, M; Hacker, DL; Beckmann, JS; Wurm, FM

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41402

Thesis Transient Gene Expression in Mammalian Cells: Promises and Challenges for Medical Biotechnology

Hacker, David L.; Baldi, Lucia; Adam, Myriam et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transient Gene Expression in Mammalian Cells: Promises and Challenges for Medical Biotechnology

Authors: Hacker, David L.; Baldi, Lucia; Adam, Myriam; Wurm, Florian M.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/50531

Thesis Productive replication of adeno-associated virus can occur in human papillomavirus type 16 (HPV-16) episome-containing keratinocytes and is augmented by the HPV-16 E2 protein

Ogston, P.; Raj, K.; Beard, P. · 2008 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Productive replication of adeno-associated virus can occur in human papillomavirus type 16 (HPV-16) episome-containing keratinocytes and is augmented by the HPV-16 E2 protein

Authors: Ogston, P.; Raj, K.; Beard, P.

Year: 2008

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/17444

Thesis Accelerating the development time of recombinant mammalian cell lines producing high titers of protein therapeutics

Chenuet, Sébastien · 2008 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Accelerating the development time of recombinant mammalian cell lines producing high titers of protein therapeutics

Authors: Chenuet, Sébastien

Year: 2008

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/25783

Thesis Lentiviral and Adeno-Associated Vector-Based Therapy for Motor Neuron Disease Through RNAi

Towne, C.; Aebischer, P · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Lentiviral and Adeno-Associated Vector-Based Therapy for Motor Neuron Disease Through RNAi

Authors: Towne, C.; Aebischer, P

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/40383

Thesis Recombinant therapeutic protein production in cultivated mammalian cells: current status and future prospects

Matasci, Mattia; Hacker, David L.; Baldi, Lucia et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Recombinant therapeutic protein production in cultivated mammalian cells: current status and future prospects

Authors: Matasci, Mattia; Hacker, David L.; Baldi, Lucia; Wurm, Florian M.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/48115

Thesis Valproic acid enhances recombinant mRNA and protein levels in transiently transfected Chinese hamster ovary cells

Wulhfard, Sarah; Baldi, Lucia; Hacker, David L. et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Valproic acid enhances recombinant mRNA and protein levels in transiently transfected Chinese hamster ovary cells

Authors: Wulhfard, Sarah; Baldi, Lucia; Hacker, David L.; Wurm, Florian

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/52514

Thesis Mild hypothermia improves transient gene expression yields several fold in Chinese hamster ovary cells

Wulhfard, S; Tissot, S; Bouchet, S et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Mild hypothermia improves transient gene expression yields several fold in Chinese hamster ovary cells

Authors: Wulhfard, S; Tissot, S; Bouchet, S; Cevey, J; De Jesus, M; Hacker, DL; Wurm, FM

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41413

Thesis A simple and highly effective method for the stable transduction of uncultured porcine hepatocytes using lentiviral vector

Nguyen, T. H.; Khakhoulina, T.; Simmons, A. et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A simple and highly effective method for the stable transduction of uncultured porcine hepatocytes using lentiviral vector

Authors: Nguyen, T. H.; Khakhoulina, T.; Simmons, A.; Morel, P.; Trono, Didier

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/50927

Thesis Polyethylenimine-mediated transient transfectionn of CHO cells in conditioned medium

Duhr, Ralph · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Polyethylenimine-mediated transient transfectionn of CHO cells in conditioned medium

Authors: Duhr, Ralph

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/44140

Thesis Measurable parameters of cells and precipitate predict transfectability with calcium phosphate

Jordan, M.; Wurm, F. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Measurable parameters of cells and precipitate predict transfectability with calcium phosphate

Authors: Jordan, M.; Wurm, F.

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/70789

Thesis Lentiviral Vector-Mediated Gene Delivery for the Generation of Chinese Hamster Ovary Cell Lines with Improved Productivity and Stability

Oberbek, Agata · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Lentiviral Vector-Mediated Gene Delivery for the Generation of Chinese Hamster Ovary Cell Lines with Improved Productivity and Stability

Authors: Oberbek, Agata

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/52293

Thesis A simple high-yielding process for transient gene expression in CHO cells

Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia et al. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A simple high-yielding process for transient gene expression in CHO cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/70206

Thesis Transient Gene Expression in HEK-293E Cells for Recombinant Protein Production : Process Characterization towards GMP Approval

Nallet, Sophie · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transient Gene Expression in HEK-293E Cells for Recombinant Protein Production : Process Characterization towards GMP Approval

Authors: Nallet, Sophie

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/52010

Thesis Isolation and evaluation of novel adeno-associated virus sequences from porcine tissues

Bello, A.; Tran, K.; Chand, A. et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Isolation and evaluation of novel adeno-associated virus sequences from porcine tissues

Authors: Bello, A.; Tran, K.; Chand, A.; Doria, M.; Allocca, M.; Hildinger, M.; Beniac, D.; Kranendonk, C.; Auricchio, A.; Kobinger, G. P.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/56639

Thesis Generation of stable, high-producing cho cell lines by lentiviral vector-mediated gene transfer in serum-free suspension culture

Oberbek, Agata; Matasci, Mattia; Hacker, David L. et al. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Generation of stable, high-producing cho cell lines by lentiviral vector-mediated gene transfer in serum-free suspension culture

Authors: Oberbek, Agata; Matasci, Mattia; Hacker, David L.; Wurm, Florian M.

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/64220

Thesis Gene transfer and protein dynamics in stem cells using single cell electroporation in a microfluidic device

Valero, A.; Post, J. N.; van Nieuwkasteele, J. W. et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Gene transfer and protein dynamics in stem cells using single cell electroporation in a microfluidic device

Authors: Valero, A.; Post, J. N.; van Nieuwkasteele, J. W.; ter Braak, P. M.; Kruijer, W.; van den Berg, A.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/61671

Thesis Glycan variability on a recombinant IgG antibody transiently produced in HEK-293E cells

Nallet, Sophie; Fornelli, Luca; Schmitt, Simone et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Glycan variability on a recombinant IgG antibody transiently produced in HEK-293E cells

Authors: Nallet, Sophie; Fornelli, Luca; Schmitt, Simone; Parra, Julien; Baldi, Lucia; Tsybin, Yury O.; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/79951

Thesis Poly(ethyleneimine)-Mediated Large-Scale Transient Gene Expression: Influence of Molecular Weight, Polydispersity and N-Propionyl Groups

Kadlecova, Zuzana; Nallet, Sophie; Hacker, David L. et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Poly(ethyleneimine)-Mediated Large-Scale Transient Gene Expression: Influence of Molecular Weight, Polydispersity and N-Propionyl Groups

Authors: Kadlecova, Zuzana; Nallet, Sophie; Hacker, David L.; Baldi, Lucia; Klok, Harm-Anton; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/81225

Thesis Cellular transfection of small interfering ribonucleic acids. Electroporation as an alternative to liposome-based delivery transfection methods

Jacot, Guillaume · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Cellular transfection of small interfering ribonucleic acids. Electroporation as an alternative to liposome-based delivery transfection methods

Authors: Jacot, Guillaume

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/57785

Thesis High-density transfection with HEK-293 cells allows doubling of transient titers and removes need for a priori DNA complex formation with PEI

Backliwal, Gaurav; Hildinger, Markus; Hasija, Vivek et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: High-density transfection with HEK-293 cells allows doubling of transient titers and removes need for a priori DNA complex formation with PEI

Authors: Backliwal, Gaurav; Hildinger, Markus; Hasija, Vivek; Wurm, Florian M.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/58379

Thesis The use of filler DNA for improved transfection and reduced DNA needs in transient gene expression with CHO and HEK cells

Kiseljak, Divor; Rajendra, Yashas; Manoli, Sagar S. et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: The use of filler DNA for improved transfection and reduced DNA needs in transient gene expression with CHO and HEK cells

Authors: Kiseljak, Divor; Rajendra, Yashas; Manoli, Sagar S.; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76413

Thesis Two strategies to improve transient gene expression in HEK293E and/or CHO-DG44 cells

Lüthi, Guillaume · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Two strategies to improve transient gene expression in HEK293E and/or CHO-DG44 cells

Authors: Lüthi, Guillaume

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76255

Thesis Gene Delivery with Hyperbranched Polylysine

Kadlecova, Zuzana · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Gene Delivery with Hyperbranched Polylysine

Authors: Kadlecova, Zuzana

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/71146

Thesis Large-Scale Transfection of Mammalian Cells

Baldi, Lucia; Hacker, David L.; Meerschman, Carine et al. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Large-Scale Transfection of Mammalian Cells

Authors: Baldi, Lucia; Hacker, David L.; Meerschman, Carine; Wurm, Florian M.

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/71799

Thesis Novel orbital shake bioreactors for transient production of CHO derived IgGs

Stettler, Matthieu; Zhang, Xiaowei; Hacker, David L. et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Novel orbital shake bioreactors for transient production of CHO derived IgGs

Authors: Stettler, Matthieu; Zhang, Xiaowei; Hacker, David L.; De Jesus, Maria; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/83449

Thesis Hyperbranched Polylysine: A Versatile, Biodegradable Transfection Agent for the Production of Recombinant Proteins by Transient Gene Expression and the Transfection of Primary Cells

Kadlecova, Zuzana; Rajendra, Yashas; Matasci, Mattia et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Hyperbranched Polylysine: A Versatile, Biodegradable Transfection Agent for the Production of Recombinant Proteins by Transient Gene Expression and the Transfection of Primary Cells

Authors: Kadlecova, Zuzana; Rajendra, Yashas; Matasci, Mattia; Hacker, David; Baldi, Lucia; Wurm, Florian Maria; Klok, Harm-Anton

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/82461

Thesis Role of non-specific DNA in reducing coding DNA requirement for transient gene expression with CHO and HEK-293E cells

Rajendra, Yashas; Kiseljak, Divor; Manoli, Sagar et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Role of non-specific DNA in reducing coding DNA requirement for transient gene expression with CHO and HEK-293E cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Manoli, Sagar; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/82394

Thesis Influence of glutamine on transient and stable recombinant protein production in CHO and HEK-293 cells

Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Influence of glutamine on transient and stable recombinant protein production in CHO and HEK-293 cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76415

Thesis The Use of Valproic Acid in Transient Gene Expression with HEK-293E Cells

Kiseljak, Divor · 2013 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: The Use of Valproic Acid in Transient Gene Expression with HEK-293E Cells

Authors: Kiseljak, Divor

Year: 2013

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/87934

Thesis Development of plasmid-based expression technology for rapid and sustained production of recombinant proteins in insect cells

Shen, Xiao · 2014 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Development of plasmid-based expression technology for rapid and sustained production of recombinant proteins in insect cells

Authors: Shen, Xiao

Year: 2014

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/109165

Thesis Transcriptional and post-transcriptional limitations of high-yielding, PEI-mediated transient transfection with CHO and HEK-293E cells

Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia et al. · 2015 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transcriptional and post-transcriptional limitations of high-yielding, PEI-mediated transient transfection with CHO and HEK-293E cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia; Wurm, Florian M.; Hacker, David L.

Year: 2015

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/113973

Thesis Virus-free transient protein production in Sf9 cells

Shen, Xiao; Hacker, David L.; Baldi, Lucia et al. · 2014 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Virus-free transient protein production in Sf9 cells

Authors: Shen, Xiao; Hacker, David L.; Baldi, Lucia; Wurm, Florian M.

Year: 2014

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/102401

Thesis An Adeno-Associated Virus-Based Intracellular Sensor of Pathological Nuclear Factor-kappa B Activation for Disease-Inducible Gene Transfer

Chtarto, Abdelwahed; Bockstael, Olivier; Gebara, Elias et al. · 2013 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: An Adeno-Associated Virus-Based Intracellular Sensor of Pathological Nuclear Factor-kappa B Activation for Disease-Inducible Gene Transfer

Authors: Chtarto, Abdelwahed; Bockstael, Olivier; Gebara, Elias; Vermoesen, Katia; Melas, Catherine; Pythoud, Catherine; Levivier, Marc; De Witte, Olivier; Luthi-Carter, Ruth; Clinkers, Ralph; Tenenbaum, Liliane

Year: 2013

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/91645

Thesis Polyethyleneimine-based transient gene expression processes for suspension-adapted HEK-293E and CHO-DG44 cells

Hacker, David L.; Kiseljak, Divor; Rajendra, Yashas et al. · 2013 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Polyethyleneimine-based transient gene expression processes for suspension-adapted HEK-293E and CHO-DG44 cells

Authors: Hacker, David L.; Kiseljak, Divor; Rajendra, Yashas; Thurnheer, Sarah; Baldi, Lucia; Wurm, Florian M.

Year: 2013

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/97430

Thesis Comparison of Three Transposons for the Generation of Highly Productive Recombinant CHO Cell Pools and Cell Lines

Balasubramanian, Sowmya; Rajendra, Yashas; Baldi, Lucia et al. · 2016 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Comparison of Three Transposons for the Generation of Highly Productive Recombinant CHO Cell Pools and Cell Lines

Authors: Balasubramanian, Sowmya; Rajendra, Yashas; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2016

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/127664

Thesis A simple plasmid-based transient gene expression method using High Five cells

Shen, Xiao; Pitol, Ana K.; Bachmann, Virginie et al. · 2016 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A simple plasmid-based transient gene expression method using High Five cells

Authors: Shen, Xiao; Pitol, Ana K.; Bachmann, Virginie; Hacker, David L.; Baldi, Lucia; Wurm, Florian M.

Year: 2016

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/123880

Thesis POLY(BETA-AMINO ESTER)-POLYETHYLENIMINE-BASED NANOPARTICLE TRANSFECTION FOR ADENO-ASSOCIATED VIRUS PRODUCTION

Alla, Sri Sai Vivek · 2023 · Johns Hopkins University · DOI

Full title: POLY(BETA-AMINO ESTER)-POLYETHYLENIMINE-BASED NANOPARTICLE TRANSFECTION FOR ADENO-ASSOCIATED VIRUS PRODUCTION

Authors: Alla, Sri Sai Vivek

Year: 2023

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/68568

Thesis Rapid recombinant protein production from piggyBac transposon-mediated stable CHO cell pools

Balasubramanian, Sowmya; Matasci, Mattia; Kadlecova, Zuzana et al. · 2015 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Rapid recombinant protein production from piggyBac transposon-mediated stable CHO cell pools

Authors: Balasubramanian, Sowmya; Matasci, Mattia; Kadlecova, Zuzana; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2015

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/113975

Thesis A stable system for the high-titer production of multiply attenuated lentiviral vectors

Klages, N; Zufferey, R; Trono, Didier · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A stable system for the high-titer production of multiply attenuated lentiviral vectors

Authors: Klages, N; Zufferey, R; Trono, Didier

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/215862

Thesis Enhanced Plasmid DNA Utilization in Transiently Transfected CHO-DG44 Cells in the Presence of Polar Solvents

Rajendra, Yashas; Balasubramanian, Sowmya; Kiseljak, Divor et al. · 2016 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Enhanced Plasmid DNA Utilization in Transiently Transfected CHO-DG44 Cells in the Presence of Polar Solvents

Authors: Rajendra, Yashas; Balasubramanian, Sowmya; Kiseljak, Divor; Baldi, Lucia; Wurm, Florian M.; Hacker, David L.

Year: 2016

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/124119

Thesis Tuning Post-Translational Modifications in Mammalian Cells: Exploring Media Optimization and Gene Editing Strategies

Aliyu, Lateef · 2025 · Johns Hopkins University · DOI

Full title: Tuning Post-Translational Modifications in Mammalian Cells: Exploring Media Optimization and Gene Editing Strategies

Authors: Aliyu, Lateef

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70660

Thesis The use of RNA interference to increase PEI-mediated transient gene expression in mammalian cells

Bertschinger, Martin · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: The use of RNA interference to increase PEI-mediated transient gene expression in mammalian cells

Authors: Bertschinger, Martin

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/221656

Thesis Highly efficient lentiviral vector-mediated transduction of nondividing, fully reimplantable primary hepatocytes

Nguyen, Tuan Huy; Oberholzer, José; Birraux, Jacques et al. · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Highly efficient lentiviral vector-mediated transduction of nondividing, fully reimplantable primary hepatocytes

Authors: Nguyen, Tuan Huy; Oberholzer, José; Birraux, Jacques; Majno, Pietro; Morel, Philippe; Trono, Didier

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/215880

Thesis HIGH-THROUGHPUT APPROACHES TO PROTEIN ENGINEERING APPLIED TO THE CAS9 AND AAV2 REP GENES

Spisak, Shaun Thomas · 2025 · Johns Hopkins University · DOI

Full title: HIGH-THROUGHPUT APPROACHES TO PROTEIN ENGINEERING APPLIED TO THE CAS9 AND AAV2 REP GENES

Authors: Spisak, Shaun Thomas

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70232

Thesis Understanding mammalian cell metabolism and developing cell culture strategies for enhanced manufacturing of biotherapeutics

Ladiwala, Pranay · 2025 · Johns Hopkins University · DOI

Full title: Understanding mammalian cell metabolism and developing cell culture strategies for enhanced manufacturing of biotherapeutics

Authors: Ladiwala, Pranay

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70273

Thesis Optimization of Recombinant Protein Production in Different Cell Lines

Ouyang, Chu · 2024 · Johns Hopkins University · DOI

Full title: Optimization of Recombinant Protein Production in Different Cell Lines

Authors: Ouyang, Chu

Year: 2024

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/69633

Thesis BRIDGING EXPERIMENTAL AND IN-SILICO METHODS FOR ADVANCED MAMMALIAN BIOMANUFACTURING OPTIMIZATION

Ndahiro, Nelson · 2025 · Johns Hopkins University · DOI

Full title: BRIDGING EXPERIMENTAL AND IN-SILICO METHODS FOR ADVANCED MAMMALIAN BIOMANUFACTURING OPTIMIZATION

Authors: Ndahiro, Nelson

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70287

Thesis Design of a Novel Gene Therapy Construct to Achieve Sustained Brain-Derived Neurotrophic Factor Signaling in Neurons

Osborne, A; Wang, AXZ; Tassoni, A et al. · 2020 · University of Melbourne · DOI

Full title: Design of a Novel Gene Therapy Construct to Achieve Sustained Brain-Derived Neurotrophic Factor Signaling in Neurons

Authors: Osborne, A; Wang, AXZ; Tassoni, A; Widdowson, PS; Martin, KR

Year: 2020

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/250906

Thesis Impact of chemically defined culture media formulations on extracellular vesicle production by amniotic epithelial cells

Zhu, D; Fang, H; Kusuma, GD et al. · 2023 · University of Melbourne · DOI

Full title: Impact of chemically defined culture media formulations on extracellular vesicle production by amniotic epithelial cells

Authors: Zhu, D; Fang, H; Kusuma, GD; Schwab, R; Barabadi, M; Chan, ST; McDonald, H; Leong, CM; Wallace, EM; Greening, DW; Lim, R

Year: 2023

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/338110

Thesis The efficiency of nuclear plasmid DNA delivery is a critical determinant of transgene expression at the single cell level

Glover, DJ; Leyton, DL; Moseley, GW et al. · 2015 · University of Melbourne · DOI

Full title: The efficiency of nuclear plasmid DNA delivery is a critical determinant of transgene expression at the single cell level

Authors: Glover, DJ; Leyton, DL; Moseley, GW; Jans, DA

Year: 2015

Venue: University of Melbourne

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000273895600008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c

Thesis Methods for in vivo CRISPR/cas editing of the adult murine retina

Hung, SS; Li, F; Wang, JH et al. · 2022 · University of Melbourne · DOI

Full title: Methods for in vivo CRISPR/cas editing of the adult murine retina

Authors: Hung, SS; Li, F; Wang, JH; King, AE; Bui, BV; Liu, GS; Hewitt, AW

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/306406

Thesis MG53 AAV Constructs as a Gene Therapy for Dysferlinopathies

Kern, Benjamen · 2024 · The Ohio State University · DOI

Full title: MG53 AAV Constructs as a Gene Therapy for Dysferlinopathies

Authors: Kern, Benjamen

Year: 2024

Venue: The Ohio State University

DOI: https://kb.osu.edu/handle/1811/104305

Thesis STRUCTURAL IMPLICATIONS OF GLUCOSE AND COPPER AVAILABILITY ON GLYCATION PROCESSES IN CHINESE HAMSTER OVARIAN (CHO) CELL-DERIVED PROTEINS

Vasamsetti, Sree Lakshmi Harita · 2025 · Johns Hopkins University · DOI

Full title: STRUCTURAL IMPLICATIONS OF GLUCOSE AND COPPER AVAILABILITY ON GLYCATION PROCESSES IN CHINESE HAMSTER OVARIAN (CHO) CELL-DERIVED PROTEINS

Authors: Vasamsetti, Sree Lakshmi Harita

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70784

Thesis A strategy to establish a gene-activated matrix on titanium using gene vectors protected in a polylactide coating.

Kolk, A; Haczek, C; Koch, C et al. · 2011 · Technical University of Munich (TUM) · DOI

Full title: A strategy to establish a gene-activated matrix on titanium using gene vectors protected in a polylactide coating.

Authors: Kolk, A;Haczek, C;Koch, C;Vogt, S;Kullmer, M;Pautke, C;Deppe, H;Plank, C

Year: 2011

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1100141

Thesis The Use of Enhanced Green Fluorescent Protein-Expressing Cell-Based Platform for Cancer Drug Screening

Sajid, Sameeha · 2019 · The Ohio State University · DOI

Full title: The Use of Enhanced Green Fluorescent Protein-Expressing Cell-Based Platform for Cancer Drug Screening

Authors: Sajid, Sameeha

Year: 2019

Venue: The Ohio State University

DOI: http://hdl.handle.net/1811/87586

Thesis Optimization of Novel Lipid Nanoparticle Formulations for mRNA Delivery

Bohmer, Margaret · 2022 · The Ohio State University · DOI

Full title: Optimization of Novel Lipid Nanoparticle Formulations for mRNA Delivery

Authors: Bohmer, Margaret

Year: 2022

Venue: The Ohio State University

DOI: http://hdl.handle.net/1811/101272

Thesis Optimizing Adenoviral Transduction of Endothelial Cells under Flow Conditions.

Anton, M; Wolf, A; Mykhaylyk, O et al. · 2012 · Technical University of Munich (TUM) · DOI

Full title: Optimizing Adenoviral Transduction of Endothelial Cells under Flow Conditions.

Authors: Anton, M;Wolf, A;Mykhaylyk, O;Koch, C;Gansbacher, B;Plank, C

Year: 2012

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1181340

Thesis Magselectofection: an integrated method of nanomagnetic separation and genetic modification of target cells.

Sánchez-Antequera, Y; Mykhaylyk, O; van Til, NP et al. · 2011 · Technical University of Munich (TUM) · DOI

Full title: Magselectofection: an integrated method of nanomagnetic separation and genetic modification of target cells.

Authors: Sánchez-Antequera, Y;Mykhaylyk, O;van Til, NP;Cengizeroglu, A;de Jong, JH;Huston, MW;Anton, M;Johnston, IC;Pojda, Z;Wagemaker, G;Plank, C

Year: 2011

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1073080

Thesis A novel expression and purification system for the production of enzymatic and biologically active human granzyme B.

Gehrmann, M; Doss, BT; Wagner, M et al. · 2011 · Technical University of Munich (TUM) · DOI

Full title: A novel expression and purification system for the production of enzymatic and biologically active human granzyme B.

Authors: Gehrmann, M;Doss, BT;Wagner, M;Zettlitz, KA;Kontermann, RE;Foulds, G;Pockley, AG;Multhoff, G

Year: 2011

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1100189

Thesis Application of aqueous two-phase micellar system to improve extraction of adenoviral particles from cell lysate

Dutra Molino, Joao Vitor; Lopes, Andre Moreni [UNESP]; Viana Marques, Daniela de Araujo et al. · 2018 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Application of aqueous two-phase micellar system to improve extraction of adenoviral particles from cell lysate

Authors: Dutra Molino, Joao Vitor; Lopes, Andre Moreni [UNESP]; Viana Marques, Daniela de Araujo; Mazzola, Priscila Gava; Silva, Joas Lucas da; Hirata, Mario Hiroyuki; Crespo Hirata, Rosario Dominguez; Viccari Gatti, Maria Silvia; Pessoa, Adalberto

Year: 2018

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1002/bab.1627

Thesis A microfluidics-based paradigm for clinical lentivector gene transfer

Tran, Reginald · 2018 · Georgia Institute of Technology · DOI

Full title: A microfluidics-based paradigm for clinical lentivector gene transfer

Authors: Tran, Reginald

Year: 2018

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/59163

Thesis Optimization of artificial neural network by genetic algorithm for describing viral production from uniform design data

Takahashi, Maria Beatriz [UNESP]; Rocha, Jose Celso [UNESP]; Fernandez Nunez, Eutimio Gustavo [UNESP] · 2018 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Optimization of artificial neural network by genetic algorithm for describing viral production from uniform design data

Authors: Takahashi, Maria Beatriz [UNESP]; Rocha, Jose Celso [UNESP]; Fernandez Nunez, Eutimio Gustavo [UNESP]

Year: 2018

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1016/j.procbio.2015.12.005

Thesis Use of uniform designs in combination with neural networks for viral infection process development

Buenno, Laís Hara; Rocha, José Celso; Leme, Jaci et al. · 2015 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Use of uniform designs in combination with neural networks for viral infection process development

Authors: Buenno, Laís Hara; Rocha, José Celso; Leme, Jaci; Caricati, Celso Pereira; Tonso, Aldo; Nuñez, Eutimio Gustavo Fernández [UNESP]

Year: 2015

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://onlinelibrary.wiley.com/doi/10.1002/btpr.2051/abstract

Thesis Guide to Electroporation and Electrofusion

Chang, Donald Choy LIFS; Saunders, James A.; Chassy, Bruce M. et al. · 2012 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Guide to Electroporation and Electrofusion

Authors: Chang, Donald Choy LIFS; Saunders, James A.; Chassy, Bruce M.; Sowers, Arthur E.

Year: 2012

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-100345

Thesis Single-Cell Impedance Cytometry for the Control of Single-Cell Electroporation in a Flow-Through Device

Rudge, Josiah · 2025 · Georgia Institute of Technology · DOI

Full title: Single-Cell Impedance Cytometry for the Control of Single-Cell Electroporation in a Flow-Through Device

Authors: Rudge, Josiah

Year: 2025

Venue: Georgia Institute of Technology

DOI: https://hdl.handle.net/1853/77892

Thesis mRNA Delivery and Storage by Co-Assembling Nanostructures with Designer Oligopeptides

Feng, Ruilu; Chang, Atta Cheuk Yan; Ni, Rong et al. · 2022 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: mRNA Delivery and Storage by Co-Assembling Nanostructures with Designer Oligopeptides

Authors: Feng, Ruilu; Chang, Atta Cheuk Yan; Ni, Rong; Li, Jacky Cheuk Yin; Chau, Ying

Year: 2022

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-119181

Thesis Designing Targeted Biological Tools to Study Musculoskeletal Diseases

O'Donohue, Alexandra Kathleen · 2023 · University of Sydney · DOI

Full title: Designing Targeted Biological Tools to Study Musculoskeletal Diseases

Authors: O'Donohue, Alexandra Kathleen

Year: 2023

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/30119

Thesis 携带CML28基因的2型重组腺相关病毒的构建及体外转染树突状细胞

解麗華; 冼韻儀; 謝雍 · 2009 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: 携带CML28基因的2型重组腺相关病毒的构建及体外转染树突状细胞

Authors: 解麗華; 冼韻儀; 謝雍

Year: 2009

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-17515

Thesis Cell and Gene Therapy Strategies for Treatment of Bone Fragility Disorders

Lee, Lucinda · 2020 · University of Sydney · DOI

Full title: Cell and Gene Therapy Strategies for Treatment of Bone Fragility Disorders

Authors: Lee, Lucinda

Year: 2020

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/22007

Thesis Living myocardial slices for the study of nucleic acid-based therapies

Nunez-Toldra, Raquel; Del Canizo, A; Secco, I et al. · 2023 · Imperial College London · DOI

Full title: Living myocardial slices for the study of nucleic acid-based therapies

Authors: Nunez-Toldra, Raquel; Del Canizo, A; Secco, I; Nicastro, L; Giacca, M; Terracciano, Cesare

Year: 2023

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/107432

Thesis Uncertainty quantification for gene delivery methods: a roadmap for pDNA manufacturing from phase I clinical trials to commercialization

Triantafyllou, Niki; Sarkis, Miriam; Krassakopoulou, Aikaterina et al. · 2024 · Imperial College London · DOI

Full title: Uncertainty quantification for gene delivery methods: a roadmap for pDNA manufacturing from phase I clinical trials to commercialization

Authors: Triantafyllou, Niki; Sarkis, Miriam; Krassakopoulou, Aikaterina; Shah, Nilay; Papathanasiou, Maria M; Kontoravdi, Cleo

Year: 2024

Venue: Imperial College London

DOI: http://dx.doi.org/10.1002/biot.202300103

Thesis Characterization of key manufacturing uncertainties in next generation therapeutics and vaccines across scales

Sarkis, Miriam; Shah, Nilay; Papathanasiou, Maria M · 2024 · Imperial College London · DOI

Full title: Characterization of key manufacturing uncertainties in next generation therapeutics and vaccines across scales

Authors: Sarkis, Miriam; Shah, Nilay; Papathanasiou, Maria M

Year: 2024

Venue: Imperial College London

DOI: http://dx.doi.org/10.1002/amp2.10158

Thesis Comparison between direct and reverse electroporation of cells in situ: a simulation study

Krams, R; Towhidi, L; Khodadadi, D et al. · 2016 · Imperial College London · DOI

Full title: Comparison between direct and reverse electroporation of cells in situ: a simulation study

Authors: Krams, R; Towhidi, L; Khodadadi, D; Maimari, N; Pedrigi, R; Ip, H; Kis, Z; Kwak, B; Petrova, T; Delorenzi, M

Year: 2016

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/29941

Thesis Epicardial cell transfection with cationic polymeric nanocomplexes

Brito, L; Mylonaki, I; Moroz, E et al. · 2020 · Imperial College London · DOI

Full title: Epicardial cell transfection with cationic polymeric nanocomplexes

Authors: Brito, L; Mylonaki, I; Moroz, E; Grigsby, C; Smart, N; Rosenthal, N; Harding, SE; Stevens, MM

Year: 2020

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000462496800033&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis One size does not fit all: The effect of chain length and charge density of poly(ethylene imine) based copolymers on delivery of pDNA, mRNA, and repRNA polyplexes.

Blakney, Anna K; Yilmaz, Gokhan; McKay, Paul F et al. · 2018 · Imperial College London · DOI

Full title: One size does not fit all: The effect of chain length and charge density of poly(ethylene imine) based copolymers on delivery of pDNA, mRNA, and repRNA polyplexes.

Authors: Blakney, Anna K; Yilmaz, Gokhan; McKay, Paul F; Becer, C Remzi; Shattock, Robin J

Year: 2018

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/29698602

Thesis Enhanced nanomagnetic gene transfection of human prenatal cardiac progenitor cells and adult cardiomyocytes

Subramanian, Mahendran; Lim, Jenson; Dobson, Jon · 2020 · Imperial College London · DOI

Full title: Enhanced nanomagnetic gene transfection of human prenatal cardiac progenitor cells and adult cardiomyocytes

Authors: Subramanian, Mahendran; Lim, Jenson; Dobson, Jon

Year: 2020

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000322633700046&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Gene replacement ameliorates deficits in mouse and human models of cyclin-dependent kinase-like 5 disorder

Yunan Gao, Yunan; Irvine, Elaine; Eleftheriadou, Ioanna et al. · 2020 · Imperial College London · DOI

Full title: Gene replacement ameliorates deficits in mouse and human models of cyclin-dependent kinase-like 5 disorder

Authors: Yunan Gao, Yunan; Irvine, Elaine; Eleftheriadou, Ioanna; Naranjo, Carlos Jimenez; Hearn-Yeats, Francesca; Bosch, Leontien; Glegola, Justina; Murdoch, Leah; Czerniak, Aleksandra; Meloni, Ilaria; Renieri, Alessandra; Kinali, Maria; Mazarakis, Nicholas D

Year: 2020

Venue: Imperial College London

DOI: https://academic.oup.com/brain/article/143/3/811/5775569

Thesis Polymeric Nanoparticles of Chitosan Derivatives as DNA and siRNA Carriers

Kim, Y. K.; Jiang, H. L.; Choi, Y. J. et al. · 2021 · Seoul National University · DOI

Full title: Polymeric Nanoparticles of Chitosan Derivatives as DNA and siRNA Carriers

Authors: Kim, Y. K.; Jiang, H. L.; Choi, Y. J.; Park, I. K.; Cho, M. H.; Cho, C. S.

Year: 2021

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/172291

Thesis Bacteriophage mediates efficient gene transfer in combination with conventional transfection reagents

Donnelly, A; Yata, T; Bentayebi, K et al. · 2015 · Imperial College London · DOI

Full title: Bacteriophage mediates efficient gene transfer in combination with conventional transfection reagents

Authors: Donnelly, A; Yata, T; Bentayebi, K; Suwan, K; Hajitou, A

Year: 2015

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/28249

Thesis Engineering pseudovirions for large-scale targeted gene transfer and recombinant adeno-associated virus production

Asavarut, Paladd · 2021 · Imperial College London · DOI

Full title: Engineering pseudovirions for large-scale targeted gene transfer and recombinant adeno-associated virus production

Authors: Asavarut, Paladd

Year: 2021

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/86379

Thesis Selective inhibition of histone deacetylation in melanoma increases targeted gene delivery by a bacteriophage viral vector

Hajitou, A; Campbell, Samuel; Suwan, Keittisak et al. · 2018 · Imperial College London · DOI

Full title: Selective inhibition of histone deacetylation in melanoma increases targeted gene delivery by a bacteriophage viral vector

Authors: Hajitou, A; Campbell, Samuel; Suwan, Keittisak; Waramit, Sajee; Aboagye, eric

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/59229

Thesis Biodegradable poly(ester amine) based on glycerol dimethacrylate and polyethylenimine as a gene carrier

Arote, Rohidas B.; Hwang, Soon-Kyung; Yoo, Mi-Kyong et al. · 2021 · Seoul National University · DOI

Full title: Biodegradable poly(ester amine) based on glycerol dimethacrylate and polyethylenimine as a gene carrier

Authors: Arote, Rohidas B.; Hwang, Soon-Kyung; Yoo, Mi-Kyong; Jere, Dhananjay; Jiang, Hu-Lin; Kim, You-Kyoung; Choi, Yun-Jai; Nah, Jae-Woon; Cho, Myung-Haing; Cho, Chong-Su

Year: 2021

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/172428

Thesis Chemical modification of chitosan as a gene carrier in vitro and in vivo

Kim, Tae-Hee; Jiang, Hu-Lin; Jere, Dhananjay et al. · 2009 · Seoul National University · DOI

Full title: Chemical modification of chitosan as a gene carrier in vitro and in vivo

Authors: Kim, Tae-Hee; Jiang, Hu-Lin; Jere, Dhananjay; Park, In-Kyu; Cho, Myung-Haing; Nah, Jae-Woon; Choi, Yun-Jale; Akaike, Toshihiro; Cho, Chong-Su

Year: 2009

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/8337

Thesis A biodegradable poly(ester amine) based on polycaprolactone and polyethylenimine as a gene carrier

Arote, Rohidas; Kim, Tae-Hee; Kim, You-Kyoung et al. · 2021 · Seoul National University · DOI

Full title: A biodegradable poly(ester amine) based on polycaprolactone and polyethylenimine as a gene carrier

Authors: Arote, Rohidas; Kim, Tae-Hee; Kim, You-Kyoung; Hwang, Soon-Kyung; Jiang, Hu-Lin; Song, Ho-Hyun; Nah, Jae-Woon; Cho, Myung-Haing; Cho, Chong-Su

Year: 2021

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/172337

Thesis Poly (amino ester) composed of poly (ethylene glycol) and aminosilane prepared by combinatorial chemistry as a gene carrier

Jere, Dhananjay; Yoo, Mi-Kyong; Arote, Rohidas et al. · 2021 · Seoul National University · DOI

Full title: Poly (amino ester) composed of poly (ethylene glycol) and aminosilane prepared by combinatorial chemistry as a gene carrier

Authors: Jere, Dhananjay; Yoo, Mi-Kyong; Arote, Rohidas; Kim, Tae-Hee; Cho, Myung-Haing; Nah, Jae-Woon; Choi, Yun-Jaie; Cho, Chong-Su

Year: 2021

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/172496

Thesis An Investigation into Factors affecting Ultrasound and Microbubble mediated Gene Transfection

Browning, Richard Johannes · 2012 · Imperial College London · DOI

Full title: An Investigation into Factors affecting Ultrasound and Microbubble mediated Gene Transfection

Authors: Browning, Richard Johannes

Year: 2012

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/9815

Thesis Efficient Gene Delivery with Osmotically Active and Hyperbranched Poly(ester amine)s

Arote, Rohidas B.; Lee, Eun-Sun; Jiang, Hu-Lin et al. · 2021 · Seoul National University · DOI

Full title: Efficient Gene Delivery with Osmotically Active and Hyperbranched Poly(ester amine)s

Authors: Arote, Rohidas B.; Lee, Eun-Sun; Jiang, Hu-Lin; Kim, You-Kyoung; Choi, Yun-Jaie; Cho, Myung-Haing; Cho, Chong-Su

Year: 2021

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/172328

Thesis High Gene Transfer by the Osmotic Polysorbitol-Mediated Transporter through the Selective Caveolae Endocytic Pathway

Quynh-Phuong Luu; Shin, Ji-Young; Kim, You-Kyoung et al. · 2021 · Seoul National University · DOI

Full title: High Gene Transfer by the Osmotic Polysorbitol-Mediated Transporter through the Selective Caveolae Endocytic Pathway

Authors: Quynh-Phuong Luu; Shin, Ji-Young; Kim, You-Kyoung; Islam, Mohammad Ariful; Kang, Sang-Kee; Cho, Myung-Haing; Choi, Yun-Jaie; Cho, Chong-Su

Year: 2021

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/172474

Thesis Targeted Gene Delivery via N-Acetylglucosamine Receptor Mediated Endocytosis

Singh, Bijay; Maharjan, Sushila; Kim, You-Kyoung et al. · 2021 · Seoul National University · DOI

Full title: Targeted Gene Delivery via N-Acetylglucosamine Receptor Mediated Endocytosis

Authors: Singh, Bijay; Maharjan, Sushila; Kim, You-Kyoung; Jiang, Tao; Islam, Mohammad Ariful; Kang, Sang-Kee; Cho, Myung-Haing; Choi, Yun-Jaie; Cho, Chong-Su

Year: 2021

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/172437

Thesis Improved transfection efficiency and metabolic activity in human embryonic stem cell using non-enzymatic method

Kim, C-Yoon; Hwang, In-Kyu; Kang, Changhee et al. · 2023 · Seoul National University · DOI

Full title: Improved transfection efficiency and metabolic activity in human embryonic stem cell using non-enzymatic method

Authors: Kim, C-Yoon; Hwang, In-Kyu; Kang, Changhee; Chung, Eun-Bin; Jung, Cho-Rok; Oh, Hanseul; Jeong, Young-Hoon; Moon, Sung-Hwan; Kim, Jong Soo; Hong, Ki-Sung; Park, Jae-Hak; Chung, Hyung-Min

Year: 2023

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/194756

Thesis Innate Immune Suppression Enables Frequent Transfection with RNA Encoding Reprogramming Proteins

Angel, Matthew; Yanik, Mehmet F. · 2010 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Innate Immune Suppression Enables Frequent Transfection with RNA Encoding Reprogramming Proteins

Authors: Angel, Matthew; Yanik, Mehmet F.

Year: 2010

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/107587

Thesis Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing

Williams, Thomas; Sanches, Rui; Blanchard-Emmerson, Greg et al. · 2023 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing

Authors: Williams, Thomas; Sanches, Rui; Blanchard-Emmerson, Greg; Watts, Samuel; Davies, Lee; Knevelman, Carol; McCloskey, Laura; Jones, Peter; Mitrophanous, Kyriacos; Miskin, James; Dikicioglu, Duygu

Year: 2023

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/596703

Thesis Ex Vivo/In vivo Gene Editing in Hepatocytes Using “All-in-One” CRISPR-Adeno-Associated Virus Vectors with a Self-Linearizing Repair Template

Krooss, Simon Alexander; Dai, Zhen; Schmidt, Florian et al. · 2020 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Ex Vivo/In vivo Gene Editing in Hepatocytes Using “All-in-One” CRISPR-Adeno-Associated Virus Vectors with a Self-Linearizing Repair Template

Authors: Krooss, Simon Alexander; Dai, Zhen; Schmidt, Florian; Rovai, Alice; Fakhiri, Julia; Dhingra, Akshay; Yuan, Qinggong; Yang, Taihua; Balakrishnan, Asha; Steinbrück, Lars; Srivaratharajan, Sangar; Manns, Michael Peter; Schambach, Axel; Grimm, Dirk; Bohne, Jens; Sharma, Amar Deep; Büning, Hildegard; Ott, Michael

Year: 2020

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/401187

Thesis Streamlined, single-step non-viral CRISPR-Cas9 knockout strategy enhances gene editing efficiency in primary human chondrocyte populations

Ponta, Simone; Bonato, Angela; id_orcid0000-0001-5991-2483 et al. · 2024 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Streamlined, single-step non-viral CRISPR-Cas9 knockout strategy enhances gene editing efficiency in primary human chondrocyte populations

Authors: Ponta, Simone; Bonato, Angela; id_orcid0000-0001-5991-2483; Neidenbach, Philipp; Bruhin, Valentino F.; Laurent, Alexis; Applegate, Lee Ann; Zenobi-Wong, Marcy; id_orcid0000-0001-5991-2483; Barreto, Goncalo

Year: 2024

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/665564

Thesis Hurdles to healing: Overcoming cellular barriers for viral and nonviral gene therapy

Honrath, Steffen; id_orcid0009-0003-7513-8872; Burger, Michael et al. · 2025 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Hurdles to healing: Overcoming cellular barriers for viral and nonviral gene therapy

Authors: Honrath, Steffen; id_orcid0009-0003-7513-8872; Burger, Michael; Leroux, Jean-Christophe; id_orcid0009-0003-7513-8872

Year: 2025

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/729457

Thesis Enhanced Cellular Uptake through Nanotopography-Induced Macropinocytosis

Aramesh, Morteza; id_orcid0000-0003-2071-1929; Yu, Di et al. · 2024 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Enhanced Cellular Uptake through Nanotopography-Induced Macropinocytosis

Authors: Aramesh, Morteza; id_orcid0000-0003-2071-1929; Yu, Di; Essand, Magnus; Persson, Cecilia

Year: 2024

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/665382

Thesis Closing the gap: Nonviral TFAMoplex transfection boosted by bZIP domains compared to AAV-mediated transduction

Honrath, Steffen; id_orcid0009-0003-7513-8872; Heussi, Miguel et al. · 2025 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Closing the gap: Nonviral TFAMoplex transfection boosted by bZIP domains compared to AAV-mediated transduction

Authors: Honrath, Steffen; id_orcid0009-0003-7513-8872; Heussi, Miguel; Beckert, Lukas; Scherer, David; Lim, Roderick Y.H.; Burger, Michael; Leroux, Jean-Christophe; id_orcid0009-0003-7513-8872

Year: 2025

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/731449

Thesis High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells

Hildinger, Markus; Baldi, Lucia; Stettler, Matthieu et al. · 2007 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells

Authors: Hildinger, Markus; Baldi, Lucia; Stettler, Matthieu; Wurm, Florian M.

Year: 2007

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/66202

Thesis Next-Generation Percutaneous Catheter–Based Closed-Loop Perfusion Concept Enables High-Precision Organ Delivery of Advanced Therapies

Emmert , Maximilian Y.; Holzmeister , Johannes; Blank , Ole et al. · 2025 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Next-Generation Percutaneous Catheter–Based Closed-Loop Perfusion Concept Enables High-Precision Organ Delivery of Advanced Therapies

Authors: Emmert , Maximilian Y.; Holzmeister , Johannes; Blank , Ole; Meyborg , Heike; Jomard , Anne; Mearini , Giulia; Vono , Maria; Weisskopf, Miriam; Michalski , Marco; Nagaraju , Chandan Kadur; Dehdashtian , Mark; Hollamby , Dominic; Rusconi , Chris; Zelenkofske , Steven; Falk, Volkmar; id_orcid0000-0002-7911-8620; Ayuso , Eduard; El Andari , Josef; Cesarovic , Nikola

Year: 2025

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/788000

Thesis Enhancing recombinant adeno-associated virus (rAAV) production through cell and gene engineering

Bosch Molist, Laia · 2024 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Enhancing recombinant adeno-associated virus (rAAV) production through cell and gene engineering

Authors: Bosch Molist, Laia

Year: 2024

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/692000

Thesis Desenvolupament i anàlisi d'un bioprocés per a l'obtenció de vectors adenovirals per a teràpia gènica

Gálvez Sánchez, Jordi · 2011 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Desenvolupament i anàlisi d'un bioprocés per a l'obtenció de vectors adenovirals per a teràpia gènica

Authors: Gálvez Sánchez, Jordi

Year: 2011

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://www.tdx.cat/TDX-0214111-150511

Thesis Plasmid-based electroporation for efficient genetic engineering in immortalized T lymphocytes

Xie, Yu-Qing; Fussenegger, Martin; id_orcid0000-0001-8545-667X · 2025 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Plasmid-based electroporation for efficient genetic engineering in immortalized T lymphocytes

Authors: Xie, Yu-Qing; Fussenegger, Martin; id_orcid0000-0001-8545-667X

Year: 2025

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/731909

Thesis Application of pulsed magnetic field enhances non-viral gene delivery in primary cells from different origins

Kamau Chapman, S W; Hassa, P O; Koch-Schneidemann, S et al. · 2008 · Vetsuisse Faculty Bern and Zurich · DOI

Full title: Application of pulsed magnetic field enhances non-viral gene delivery in primary cells from different origins

Authors: Kamau Chapman, S W; Hassa, P O; Koch-Schneidemann, S; von Rechenberg, Brigitte; https://orcid.org/0000-0002-3836-6812; Hofmann-Amtenbrink, M; Steitz, B; Petri-Fink, A; Hofmann, H; Hottiger, Michael O; https://orcid.org/0000-0002-7323-2270

Year: 2008

Venue: Vetsuisse Faculty Bern and Zurich

DOI: oai:www.zora.uzh.ch:20.500.14742/40137

Thesis Hepatocyte transfection in small pigs after weaning by hydrodynamic intraportal injection of naked DNA/minicircle vectors

Stoller, Fabienne; Schlegel, Andrea; Viecelli, Hiu Man et al. · 2015 · Vetsuisse Faculty Bern and Zurich · DOI

Full title: Hepatocyte transfection in small pigs after weaning by hydrodynamic intraportal injection of naked DNA/minicircle vectors

Authors: Stoller, Fabienne; Schlegel, Andrea; Viecelli, Hiu Man; Rüfenacht, Véronique; Cesarovic, Nikola; https://orcid.org/0000-0001-6744-2928; Viecelli, Claudio; Deplazes, Sereina; Bettschart, Regula; https://orcid.org/0000-0001-6259-9678; Hurter, Karin; Schmierer, Philipp; Sidler, Xaver; Kron, Philipp; https://orcid.org/0000-0002-6074-7072; Dutkowski, Philipp; Graf, Rolf; Thöny, Beat; https://orcid.org/0000-0002-8420-4769; Häberle, Johannes; https://orcid.org/0000-0003-0635-091X

Year: 2015

Venue: Vetsuisse Faculty Bern and Zurich

DOI: oai:www.zora.uzh.ch:20.500.14742/111722

Thesis Safe delivery of AAV vectors to the liver of small weaned pigs by ultrasound-guided percutaneous transhepatic portal vein injection

Rothgangl, Tanja; https://orcid.org/0000-0001-7799-2413; Hruzova, Martina et al. · 2023 · Vetsuisse Faculty Bern and Zurich · DOI

Full title: Safe delivery of AAV vectors to the liver of small weaned pigs by ultrasound-guided percutaneous transhepatic portal vein injection

Authors: Rothgangl, Tanja; https://orcid.org/0000-0001-7799-2413; Hruzova, Martina; Gnannt, Ralph; https://orcid.org/0000-0001-8120-6200; Aeberhard, Nadja; Kissling, Lucas; https://orcid.org/0000-0002-4989-0695; Grisch-Chan, Hiu Man; Klassa, Sven; Rimann, Nicole; Marquart, Kim F; https://orcid.org/0000-0001-7393-4398; Ioannidi, Eleonora; https://orcid.org/0000-0001-7964-7744; Wolf, Anja; Kupatt, Christian; Sidler, Xaver; Häberle, Johannes; https://orcid.org/0000-0003-0635-091X; Schwank, Gerald; https://orcid.org/0000-0003-0767-2953; Thöny, Beat; https://orcid.org/0000-0002-5001-086X

Year: 2023

Venue: Vetsuisse Faculty Bern and Zurich

DOI: oai:www.zora.uzh.ch:20.500.14742/214740

Thesis Adeno-associated vector-delivered CRISPR/SaCas9 system reduces Feline Leukemia Virus production in vitro

Helfer-Hungerbuehler, A Katrin; https://orcid.org/0000-0001-6954-1815; Shah, Jimit et al. · 2021 · Vetsuisse Faculty Bern and Zurich · DOI

Full title: Adeno-associated vector-delivered CRISPR/SaCas9 system reduces Feline Leukemia Virus production in vitro

Authors: Helfer-Hungerbuehler, A Katrin; https://orcid.org/0000-0001-6954-1815; Shah, Jimit; Meili, Theres; Boenzli, Eva; Li, Pengfei; Hofmann-Lehmann, Regina; https://orcid.org/0000-0001-9750-4296

Year: 2021

Venue: Vetsuisse Faculty Bern and Zurich

DOI: oai:www.zora.uzh.ch:20.500.14742/185882

Thesis Establishing the Proof-of-Concept for Hematopoietic Stem Cell-Directed Gene Therapy via Gene Editing Strategies for the Treatment of Ataxia-Telangiectasia

Sartre, Gilles Marie · 2025 · Vetsuisse Faculty Bern and Zurich · DOI

Full title: Establishing the Proof-of-Concept for Hematopoietic Stem Cell-Directed Gene Therapy via Gene Editing Strategies for the Treatment of Ataxia-Telangiectasia

Authors: Sartre, Gilles Marie

Year: 2025

Venue: Vetsuisse Faculty Bern and Zurich

DOI: oai:www.zora.uzh.ch:20.500.14742/237626

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2. Data Extraction

0/487 extracted

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Optimization of lentiviral vector production for scale-up in fixed-bed bioreactor

Valkama, Anniina J.; Leinonen, Hanna; Lipponen, Eevi M. et al. · 2017

Full title: Optimization of lentiviral vector production for scale-up in fixed-bed bioreactor

Authors: Valkama, Anniina J.; Leinonen, Hanna; Lipponen, Eevi M.; Turkki, Vesa; Malinen, Jukka; Heikura, Tommi; Ylä‐Herttuala, Seppo; Lesch, Hanna P.

DOI: https://doi.org/10.1038/gt.2017.91

Paper

Analytical characterization of full, intermediate, and empty AAV capsids.

McColl-Carboni, Aisleen; Dollive, Serena; Laughlin, Sarah et al. · 2024

Full title: Analytical characterization of full, intermediate, and empty AAV capsids.

DOI: https://doi.org/10.1038/s41434-024-00444-2

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Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington's disease.

Wu, Zheng; Parry, Matthew; Hou, Xiao-Yi et al. · 2020

Full title: Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington's disease.

Authors: Wu, Zheng; Parry, Matthew; Hou, Xiao-Yi; Liu, Min-Hui; Wang, Hui; Cain, Rachel; Pei, Zi-Fei; Chen, Yu-Chen; Guo, Zi-Yuan; Abhijeet, Sambangi; Chen, Gong

DOI: https://doi.org/10.1038/s41467-020-14855-3

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AAVvector-mediated in vivo reprogramming into pluripotency.

Senís, Elena; Mosteiro, Lluc; Wilkening, Stefan et al. · 2018

Full title: AAVvector-mediated in vivo reprogramming into pluripotency.

DOI: https://doi.org/10.1038/s41467-018-05059-x

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Self-attenuating adenovirus enables production of recombinant adeno-associated virus for high manufacturing yield without contamination

Su, Weiheng; Patrício, Maria I.; Duffy, Margaret R. et al. · 2022

Full title: Self-attenuating adenovirus enables production of recombinant adeno-associated virus for high manufacturing yield without contamination

Authors: Su, Weiheng; Patrício, Maria I.; Duffy, Margaret R.; Krakowiak, Jakub M.; Seymour, Leonard W.; Cawood, Ryan

DOI: https://doi.org/10.1038/s41467-022-28738-2

Paper

Adeno-associated virus capsid assembly is divergent and stochastic

Wörner, Tobias P.; Bennett, Antonette; Habka, Sana et al. · 2021

Full title: Adeno-associated virus capsid assembly is divergent and stochastic

Authors: Wörner, Tobias P.; Bennett, Antonette; Habka, Sana; Snijder, Joost; Friese, Olga; Powers, Thomas W.; Agbandje‐McKenna, Mavis; Heck, Albert J. R.

DOI: https://doi.org/10.1038/s41467-021-21935-5

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The membrane associated accessory protein is an adeno-associated viral egress factor

Elmore, Zachary C.; Havlik, L. Patrick; Oh, Daniel K. et al. · 2021

Full title: The membrane associated accessory protein is an adeno-associated viral egress factor

Authors: Elmore, Zachary C.; Havlik, L. Patrick; Oh, Daniel K.; Anderson, Leif; Daaboul, George G.; Devlin, Garth; Vincent, Heather A.; Asokan, Aravind

DOI: https://doi.org/10.1038/s41467-021-26485-4

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Engineering a synthetic gene circuit for high-performance inducible expression in mammalian systems

Carluccio, Giuliano De; Fusco, Virginia; Bernardo, Diego di · 2024

Full title: Engineering a synthetic gene circuit for high-performance inducible expression in mammalian systems

Authors: Carluccio, Giuliano De; Fusco, Virginia; Bernardo, Diego di

DOI: https://doi.org/10.1038/s41467-024-47592-y

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Heterogeneity in an adeno-associated virus transfection-based production process limits the production efficiency.

Ladd, Brian; Tunmats, Sofia; Gräslund, Torbjörn et al. · 2025

Full title: Heterogeneity in an adeno-associated virus transfection-based production process limits the production efficiency.

Authors: Ladd, Brian; Tunmats, Sofia; Gräslund, Torbjörn; Daramola, Olalekan; Rockberg, Johan; Chotteau, Véronique

DOI: https://doi.org/10.1038/s41598-025-26261-0

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LentiPro26: novel stable cell lines for constitutive lentiviral vector production

Tomás, Hélio A.; Rodrigues, Ana F.; Carrondo, Manuel J.T. et al. · 2018

Full title: LentiPro26: novel stable cell lines for constitutive lentiviral vector production

Authors: Tomás, Hélio A.; Rodrigues, Ana F.; Carrondo, Manuel J.T.; Coroadinha, Ana S.

DOI: https://doi.org/10.1038/s41598-018-23593-y

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Polyethylenimine based magnetic nanoparticles mediated non-viral CRISPR/Cas9 system for genome editing

Rohiwal, Sonali S.; Dvořáková, Nikola; Klı́ma, Jiřı́ et al. · 2020

Full title: Polyethylenimine based magnetic nanoparticles mediated non-viral CRISPR/Cas9 system for genome editing

DOI: https://doi.org/10.1038/s41598-020-61465-6

Paper

CRISPR/Cas9 as an antiviral against Orthopoxviruses using an AAV vector.

Siegrist, Cathryn M; Kinahan, Sean M; Settecerri, Taylor et al. · 2020

Full title: CRISPR/Cas9 as an antiviral against Orthopoxviruses using an AAV vector.

Authors: Siegrist, Cathryn M; Kinahan, Sean M; Settecerri, Taylor; Greene, Adrienne C; Santarpia, Joshua L

DOI: https://doi.org/10.1038/s41598-020-76449-9

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Engineered CHO cells as a novel AAV production platform for gene therapy delivery

Nagy, Abdou; Chakrabarti, Lina; Kurasawa, James et al. · 2023

Full title: Engineered CHO cells as a novel AAV production platform for gene therapy delivery

Authors: Nagy, Abdou; Chakrabarti, Lina; Kurasawa, James; Mulagapati, Sri Hari Raju; Devine, Paul N.; Therres, Jamy; Chen, Yuyan; Schmelzer, Albert E.

DOI: https://doi.org/10.1038/s41598-023-46298-3

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Production of adeno-associated virus vectors for in vitro and in vivo applications

Kimura, Toyokazu; Ferrán, Beatriz; Tsukahara, Yuko et al. · 2019

Full title: Production of adeno-associated virus vectors for in vitro and in vivo applications

DOI: https://doi.org/10.1038/s41598-019-49624-w

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Receptor-targeted liposome-peptide-siRNA nanoparticles represent an efficient delivery system for MRTF silencing in conjunctival fibrosis

Yu‐Wai‐Man, Cynthia; Tagalakis, Aristides D.; Manunta, Maria et al. · 2016

Full title: Receptor-targeted liposome-peptide-siRNA nanoparticles represent an efficient delivery system for MRTF silencing in conjunctival fibrosis

Authors: Yu‐Wai‐Man, Cynthia; Tagalakis, Aristides D.; Manunta, Maria; Hart, Stephen L.; Khaw, Peng T.

DOI: https://doi.org/10.1038/srep21881

Paper

Efficacy and Safety of rAAV2-ND4 Treatment for Leber's Hereditary Optic Neuropathy.

Wan, Xing; Pei, Han; Zhao, Min-jian et al. · 2016

Full title: Efficacy and Safety of rAAV2-ND4 Treatment for Leber's Hereditary Optic Neuropathy.

Authors: Wan, Xing; Pei, Han; Zhao, Min-jian; Yang, Shuo; Hu, Wei-kun; He, Heng; Ma, Si-qi; Zhang, Ge; Dong, Xiao-yan; Chen, Chen; Wang, Dao-wen; Li, Bin

DOI: https://doi.org/10.1038/srep21587

Paper

AAV Gene Therapy for MPS1-associated Corneal Blindness.

Vance, Melisa; Llanga, Telmo; Bennett, Will et al. · 2016

Full title: AAV Gene Therapy for MPS1-associated Corneal Blindness.

Authors: Vance, Melisa; Llanga, Telmo; Bennett, Will; Woodard, Kenton; Murlidharan, Giridhar; Chungfat, Neil; Asokan, Aravind; Gilger, Brian; Kurtzberg, Joanne; Samulski, R Jude; Hirsch, Matthew L

DOI: https://doi.org/10.1038/srep22131

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High-purity AAV vector production utilizing recombination-dependent minicircle formation and genetic coupling.

Liu, Hao; Liu, Nan; Zhou, Chen et al. · 2025

Full title: High-purity AAV vector production utilizing recombination-dependent minicircle formation and genetic coupling.

Authors: Liu, Hao; Liu, Nan; Zhou, Chen; Du, Ailing; Kapadia, Mayank; Tai, Phillip W L; Barton, Erik; Gao, Guangping; Wang, Dan

DOI: https://doi.org/10.1038/s44321-025-00248-w

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Intranasal gene therapy to prevent infection by SARS-CoV-2 variants

Sims, Joshua J.; Greig, Jenny A.; Michalson, Kristofer T. et al. · 2021

Full title: Intranasal gene therapy to prevent infection by SARS-CoV-2 variants

DOI: https://doi.org/10.1371/journal.ppat.1009544

Paper

Adeno-associated virus capsid assembly is divergent and stochastic

Wörner, Tobias P.; Bennett, Antonette; Habka, Sana et al. · 2021

Full title: Adeno-associated virus capsid assembly is divergent and stochastic

Authors: Wörner, Tobias P.; Bennett, Antonette; Habka, Sana; Snijder, Joost; Friese, Olga; Powers, Thomas W.; Agbandje‐McKenna, Mavis; Heck, Albert J. R.

DOI: https://doi.org/10.1038/s41467-021-21935-5

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Fast, efficient and virus-free generation of TRAC -replaced CAR T cells

Kath, Jonas; Du, Weijie; Thommandru, Bernice et al. · 2021

Full title: Fast, efficient and virus-free generation of TRAC -replaced CAR T cells

DOI: https://doi.org/10.1101/2021.02.14.431017

Paper

The membrane associated accessory protein is an adeno-associated viral egress factor

Elmore, Zachary C.; Havlik, L. Patrick; Oh, Daniel K. et al. · 2021

Full title: The membrane associated accessory protein is an adeno-associated viral egress factor

Authors: Elmore, Zachary C.; Havlik, L. Patrick; Oh, Daniel K.; Anderson, Leif; Daaboul, George G.; Devlin, Garth; Vincent, Heather A.; Asokan, Aravind

DOI: https://doi.org/10.1038/s41467-021-26485-4

Paper

Transgene Expression in Cultured Cells Using Unpurified Recombinant Adeno-Associated Viral Vectors

Benyamini, Brian; Esbin, Meagan N.; Whitney, Oscar N. et al. · 2023

Full title: Transgene Expression in Cultured Cells Using Unpurified Recombinant Adeno-Associated Viral Vectors

Authors: Benyamini, Brian; Esbin, Meagan N.; Whitney, Oscar N.; Walther, Nike; Maurer, Anna C.

DOI: https://doi.org/10.1101/2023.03.20.533580

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Evolving Membrane-Associated Accessory Protein Variants for Improved Adeno-associated Virus Production

Schieferecke, Adam J.; Lee, Hyun‐Cheol; Chen, Aleysha T. et al. · 2023

Full title: Evolving Membrane-Associated Accessory Protein Variants for Improved Adeno-associated Virus Production

Authors: Schieferecke, Adam J.; Lee, Hyun‐Cheol; Chen, Aleysha T.; Kilaru, Vindhya; Williams, Justin Krish; Schaffer, David V.

DOI: https://doi.org/10.1101/2023.07.18.549400

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The CASwitch: a synthetic biology solution for high-performance inducible gene expression systems in biotechnology

Carluccio, Giuliano De; Fusco, Virginia; Bernardo, Diego di · 2023

Full title: The CASwitch: a synthetic biology solution for high-performance inducible gene expression systems in biotechnology

Authors: Carluccio, Giuliano De; Fusco, Virginia; Bernardo, Diego di

DOI: https://doi.org/10.1101/2023.09.20.558637

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Engineered retrovirus-like nanocarriers for messenger RNA delivery into neurons

Gu, Wenchao; Luozhong, Sijin; Cai, Simian et al. · 2022

Full title: Engineered retrovirus-like nanocarriers for messenger RNA delivery into neurons

DOI: https://doi.org/10.1101/2022.12.07.518870

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Rational design of a compact CRISPR-Cas9 activator for AAV-mediated delivery

Vora, Suhani; Cheng, Jenny; Xiao, Ru et al. · 2018

Full title: Rational design of a compact CRISPR-Cas9 activator for AAV-mediated delivery

Authors: Vora, Suhani; Cheng, Jenny; Xiao, Ru; VanDusen, Nathan J.; Quintino, Luís; Pu, William T.; Vandenberghe, Luk H.; Chavez, Alejandro; Church, George M.

DOI: https://doi.org/10.1101/298620

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Two-Step Small Scale Purification of Recombinant Adeno-Associated Viruses

Chen, Shih‐Heng; Papaneri, Amy B.; Walker, Mitzie et al. · 2019

Full title: Two-Step Small Scale Purification of Recombinant Adeno-Associated Viruses

Authors: Chen, Shih‐Heng; Papaneri, Amy B.; Walker, Mitzie; Scappini, Erica; Keys, Robert D.; Martin, Negin P.

DOI: https://doi.org/10.1101/715029

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A comparison of synthetic oligodeoxynucleotides, DNA fragments and AAV-1 for targeted episomal and chromosomal gene repair

Leclerc, X.; Danos, Olivier; Scherman, Daniel et al. · 2009

Full title: A comparison of synthetic oligodeoxynucleotides, DNA fragments and AAV-1 for targeted episomal and chromosomal gene repair

Authors: Leclerc, X.; Danos, Olivier; Scherman, Daniel; Kichler, Antoine

DOI: https://doi.org/10.1186/1472-6750-9-35

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Profiling the impact of the promoters on CRISPR-Cas12a system in human cells

Li, Jinhe; Liang, Qinchun; Zhou, Huaping et al. · 2023

Full title: Profiling the impact of the promoters on CRISPR-Cas12a system in human cells

Authors: Li, Jinhe; Liang, Qinchun; Zhou, Huaping; Zhou, Ming; Huang, Hongxin

DOI: https://doi.org/10.1186/s11658-023-00454-9

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Viral vector production in the integrity® iCELLis® single-use fixed-bed bioreactor, from bench-scale to industrial scale

Lennaertz, Alexandre; Knowles, Shane; Drugmand, Jean‐Christophe et al. · 2013

Full title: Viral vector production in the integrity® iCELLis® single-use fixed-bed bioreactor, from bench-scale to industrial scale

Authors: Lennaertz, Alexandre; Knowles, Shane; Drugmand, Jean‐Christophe; Castillo, José

DOI: https://doi.org/10.1186/1753-6561-7-s6-p59

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Capsid protein expression and adeno-associated virus like particles assembly in Saccharomyces cerevisiae.

Backovic, Ana; Cervelli, Tiziana; Salvetti, Alessandra et al. · 2012

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Full title: Production of AAV vectors for gene therapy : a cost-effectiveness and risk assessment

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Use of Transient Transfection for cGMP Manufacturing of eOD-GT8 60mer, a Self-Assembling Nanoparticle Germline-Targeting HIV-1 Vaccine Candidate

Sharma, Vaneet K.; Menis, Sergey; Brower, Evan T. et al. · 2024

Full title: Use of Transient Transfection for cGMP Manufacturing of eOD-GT8 60mer, a Self-Assembling Nanoparticle Germline-Targeting HIV-1 Vaccine Candidate

DOI: https://hdl.handle.net/1721.1/155438

Thesis

Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse

Kauffman, Kevin John; Oberli, Matthias; Dorkin, Joseph Robert et al. · 2019

Full title: Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse

DOI: https://hdl.handle.net/1721.1/122015

Thesis

In vitro and ex vivo strategies for intracellular delivery

Sahay, Gaurav; Stewart, Martin P; Sharei, Armon Reza et al. · 2017

Full title: In vitro and ex vivo strategies for intracellular delivery

Authors: Sahay, Gaurav; Stewart, Martin P; Sharei, Armon Reza; Ding, Xiaoyun Sean; Langer, Robert S; Jensen, Klavs F

DOI: http://hdl.handle.net/1721.1/110923

Thesis

Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells

Nguyen, Tam N.T.; Sha, Sha; Hong, Moo Sun et al. · 2022

Full title: Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells

Authors: Nguyen, Tam N.T.; Sha, Sha; Hong, Moo Sun; Maloney, Andrew J.; Barone, Paul W.; Neufeld, Caleb; Wolfrum, Jacqueline; Springs, Stacy L.; Sinskey, Anthony J.; Braatz, Richard D.

DOI: https://hdl.handle.net/1721.1/135559.2

Thesis

Producing and Concentrating Lenti-Cre for Mouse Infections

Gierut, J. J.; Haigis, K. M.; Jacks, Tyler E. · 2018

Full title: Producing and Concentrating Lenti-Cre for Mouse Infections

Authors: Gierut, J. J.; Haigis, K. M.; Jacks, Tyler E.

DOI: http://hdl.handle.net/1721.1/116575

Thesis

Multidose transient transfection of human embryonic kidney 293 cells modulates recombinant adeno‐associated virus2/5 Rep protein expression and influences the enrichment fraction of filled capsids

Srinivasan, Prasanna; Canova, Christopher T; Sha, Sha et al. · 2024

DOI: https://hdl.handle.net/1721.1/157695

Thesis

Enhancing Production of Recombinant Proteins from Mammalian Cells

Wong, Victor V.T.; Wong, Niki S.C.; Tan, Hong-Kiat et al. · 2003

Full title: Enhancing Production of Recombinant Proteins from Mammalian Cells

Authors: Wong, Victor V.T.; Wong, Niki S.C.; Tan, Hong-Kiat; Wang, Daniel I.C.; Yap, Miranda G.S.

DOI: http://hdl.handle.net/1721.1/3782

Thesis

Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel et al. · 2025

Full title: Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Authors: Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel; Dang, Brendan; Wolffe, Lenna A; Atari, Adel; Tseng, Yuen-Yi; Love, J Christopher

DOI: https://hdl.handle.net/1721.1/163220

Thesis

Development of a Lentiviral Vector for High-Yield Production of Synthetic and Recombinant GCase for Gaucher Disease Therapy

Coelho, Ana Carolina; Wiezel, Claudia Emília Vieira; de Campos, Alline Cristina et al. · 2025

Full title: Development of a Lentiviral Vector for High-Yield Production of Synthetic and Recombinant GCase for Gaucher Disease Therapy

DOI: https://hdl.handle.net/1721.1/162371

Thesis

Perfusion‐Based Production of rAAV via an Intensified Transient Transfection Process

Nguyen, Tam NT; Park, Damdae; Canova, Christopher T et al. · 2025

Full title: Perfusion‐Based Production of rAAV via an Intensified Transient Transfection Process

DOI: https://hdl.handle.net/1721.1/162858

Thesis

Weighing the DNA Content of Adeno-Associated Virus Vectors with Zeptogram Precision Using Nanomechanical Resonators

Katsikis, Georgios; Hwang, Iris E; Wang, Wade et al. · 2023

Full title: Weighing the DNA Content of Adeno-Associated Virus Vectors with Zeptogram Precision Using Nanomechanical Resonators

DOI: https://hdl.handle.net/1721.1/146983

Thesis

A comparison of intravenous and indirect intracoronary delivery of AAV5, AAV6 and AAV9 for cardiac gene transfer in mice

Fang, Hongfei · 2011

Full title: A comparison of intravenous and indirect intracoronary delivery of AAV5, AAV6 and AAV9 for cardiac gene transfer in mice

Authors: Fang, Hongfei

DOI: https://escholarship.org/uc/item/1024d4fh

Thesis

Development of a Novel Dual AAV System for Therapeutic Delivery of BDNF

Cheng, Yuhsiang · 2018

Full title: Development of a Novel Dual AAV System for Therapeutic Delivery of BDNF

Authors: Cheng, Yuhsiang

DOI: https://escholarship.org/uc/item/3v16w70m

Thesis

Analysis of the Effects of RAS-MAPK Pathway Modulatory Adeno-associated Viral Vectors

Volz, Avery · 2024

Full title: Analysis of the Effects of RAS-MAPK Pathway Modulatory Adeno-associated Viral Vectors

Authors: Volz, Avery

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1721145531361946

Thesis

Adeno-associated virus (AAV) transduction of primary human CD4+T lymphocytes

Kamel, Sahar Hussein · 2014

Full title: Adeno-associated virus (AAV) transduction of primary human CD4+T lymphocytes

Authors: Kamel, Sahar Hussein

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=wright1409957026

Thesis

Optimalizace rekombinantní exprese proteinů v HEK293 buněčné linii

Bláha, Jan · 2017

Full title: Optimalizace rekombinantní exprese proteinů v HEK293 buněčné linii

Authors: Bláha, Jan

DOI: http://hdl.handle.net/20.500.11956/29866

Thesis

Generation of recombinant Chinese hamster ovary cell lines by microinjection

Derouazi, M.; Flaction, R.; Girard, P. et al. · 2007

Full title: Generation of recombinant Chinese hamster ovary cell lines by microinjection

Authors: Derouazi, M.; Flaction, R.; Girard, P.; de Jesus, M.; Jordan, M.; Wurm, F. M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7686

Thesis

Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Blessing, Daniel; Vachey, Gabriel; Pythoud, Catherine et al. · 2019

Full title: Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Authors: Blessing, Daniel; Vachey, Gabriel; Pythoud, Catherine; Rey, Maria; Padrun, Vivianne; Wurm, Florian M.; Schneider, Bernard L.; Deglon, Nicole

DOI: https://infoscience.epfl.ch/handle/20.500.14299/158621

Thesis

Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation

Jordan, M.; Schallhorn, A.; Wurm, F. M. · 2007

Full title: Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation

Authors: Jordan, M.; Schallhorn, A.; Wurm, F. M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7661

Thesis

Transient transfection induces different intracellular calcium signaling in CHO K1 versus HEK 293 cells

Preuss, A. K.; Connor, J. A.; Vogel, H. · 2019

Full title: Transient transfection induces different intracellular calcium signaling in CHO K1 versus HEK 293 cells

Authors: Preuss, A. K.; Connor, J. A.; Vogel, H.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/160503

Thesis

High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells

Hildinger, Markus; Baldi, Lucia; Stettler, Matthieu et al. · 2019

Full title: High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells

Authors: Hildinger, Markus; Baldi, Lucia; Stettler, Matthieu; Wurm, Florian M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/160357

Thesis

Recombinant protein production by large-scale transient gene expression in mammalian cells : state of the art and future perspectives

Baldi, L; Hacker, DL; Adam, M et al. · 2007

Full title: Recombinant protein production by large-scale transient gene expression in mammalian cells : state of the art and future perspectives

Authors: Baldi, L; Hacker, DL; Adam, M; Wurm, FM

DOI: https://infoscience.epfl.ch/handle/20.500.14299/8764

Thesis

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Lee, John; Nist-Lund, Carl; Solanes, Paola et al. · 2020

Full title: Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Authors: Lee, John; Nist-Lund, Carl; Solanes, Paola; Goldberg, Hannah; Wu, Jason; Pan, Bifeng; Schneider, Bernard L.; Holt, Jeffrey R.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/171017

Thesis

Magnetofection Potentiates Gene Delivery to Cultured Endothelial Cells

Krötz, Florian; Sohn, Hae-Young; Gloe, Torsten et al. · 2003

Full title: Magnetofection Potentiates Gene Delivery to Cultured Endothelial Cells

Authors: Krötz, Florian;Sohn, Hae-Young;Gloe, Torsten;Plank, Christian;Pohl, Ulrich

DOI: https://mediatum.ub.tum.de/1218851

Thesis

Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand

Chua, Gek Kee · 2011

Authors: Chua, Gek Kee

DOI: http://hdl.handle.net/10179/2832

Thesis

Vergleich dreier Vektorsysteme für den koronaren Gentransfer

Sack, Philipp Andreas · 2010

Full title: Vergleich dreier Vektorsysteme für den koronaren Gentransfer

Authors: Sack, Philipp Andreas

DOI: https://mediatum.ub.tum.de/602308

Thesis

Alternative Produktion rekombinanter Adeno-assoziierter Viren für die Gentherapie

Kuhrs, Annette · 2006

Full title: Alternative Produktion rekombinanter Adeno-assoziierter Viren für die Gentherapie

Authors: Kuhrs, Annette

DOI: https://refubium.fu-berlin.de/handle/fub188/12369

Thesis

Semliki Forest Virus as a Vector: Pros and Cons for Its Use in Biopharmaceuticals Production

Fernández Núñez, Eutimio Gustavo [UNESP]; Calil Jorge, Soraia Attie; Astray, Renato Mancini et al. · 2014

Full title: Semliki Forest Virus as a Vector: Pros and Cons for Its Use in Biopharmaceuticals Production

DOI: http://dx.doi.org/10.1590/S1516-89132013000500018

Thesis

Transient transfection of serum-free suspension HEK 293 cell culture for efficient production of human rFVIII

Covas, Dimas Tadeu · 2011

Full title: Transient transfection of serum-free suspension HEK 293 cell culture for efficient production of human rFVIII

Authors: Covas, Dimas Tadeu

DOI: https://doi.org/10.1186/1472-6750-11-114

Thesis

Quantitative correlation between transcriptional levels of ER chaperone, peroximal protein and FVIII productivity in human Hek-293 cell line

Covas, Dimas Tadeu · 2013

Full title: Quantitative correlation between transcriptional levels of ER chaperone, peroximal protein and FVIII productivity in human Hek-293 cell line

Authors: Covas, Dimas Tadeu

DOI: https://doi.org/10.1186/2193-1801-2-328

Thesis

Utilização de shRNA anti-hexon, anti-IVa2 e anti-pol durante a produção de vírus adeno-associado como estratégia de eliminar Adenovírus helper:: prova de princípio

Strauss, Bryan Eric · 2016

Full title: Utilização de shRNA anti-hexon, anti-IVa2 e anti-pol durante a produção de vírus adeno-associado como estratégia de eliminar Adenovírus helper:: prova de princípio

Authors: Strauss, Bryan Eric

DOI: http://www.teses.usp.br/teses/disponiveis/5/5155/tde-13032017-101533/

Thesis

Efficiency of transgene expression in bovine cells varies according to cell type and gene transfer method

Dias, Angelo José Burla · 2019

Full title: Efficiency of transgene expression in bovine cells varies according to cell type and gene transfer method

Authors: Dias, Angelo José Burla

DOI: https://doi.org/10.17533/udea.rccp.v32n1a04

Thesis

Serum-free suspension adaptation of HEK-293T cells: basis for large-scale biopharmaceutical production

Mizukami, Amanda · 2021

Full title: Serum-free suspension adaptation of HEK-293T cells: basis for large-scale biopharmaceutical production

Authors: Mizukami, Amanda

DOI: https://doi.org/10.1590/1678-4324-2021200817

Thesis

A synthetic approach to produce recombinant adeno-associated virus (rAAV) in Chinese hamster ovary (CHO) cells

Cai, Wen · 2024

Full title: A synthetic approach to produce recombinant adeno-associated virus (rAAV) in Chinese hamster ovary (CHO) cells

Authors: Cai, Wen

DOI: https://hdl.handle.net/11299/259525

Thesis

Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency

Sork, Helena; Nordin, Joel Z; Turunen, Janne J et al. · 2016

Full title: Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency

DOI: https://dspace.library.uu.nl/handle/1874/336850

Thesis

Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

Muller, N.; Derouazi, M.; Van Tilborgh, F. et al. · 2007

Full title: Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

Authors: Muller, N.; Derouazi, M.; Van Tilborgh, F.; Wulhfard, S.; Hacker, D. L.; Jordan, M.; Wurm, F. M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9754

Thesis

Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions

Backliwal, G; Hildinger, M; Chenuet, S et al. · 2009

Full title: Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions

Authors: Backliwal, G; Hildinger, M; Chenuet, S; Wulhfard, S; De Jesus, M; Wurm, FM

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41410

Thesis

Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

Zhang, Xiaowei; Garcia, Isabel Fernandez; Baldi, Lucia et al. · 2010

Full title: Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

Authors: Zhang, Xiaowei; Garcia, Isabel Fernandez; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/52051

Thesis

Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia et al. · 2012

Full title: Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/76323

Thesis

The kinetics of polyethylenimine-mediated transfection in suspension cultures of Chinese hamster ovary cells

Bertschinger, Martin; Schertenleib, Arnaud; Cevey, Jean et al. · 2010

Full title: The kinetics of polyethylenimine-mediated transfection in suspension cultures of Chinese hamster ovary cells

Authors: Bertschinger, Martin; Schertenleib, Arnaud; Cevey, Jean; Hacker, David L.; Wurm, Florian M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/58359

Thesis

Study of the improved Sf9 transient gene expression process

Shen, Xiao; Hacker, David L.; Baldi, Lucia et al. · 2014

Full title: Study of the improved Sf9 transient gene expression process

Authors: Shen, Xiao; Hacker, David L.; Baldi, Lucia; Wurm, Florian M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/100125

Thesis

A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing

Woodruff, Kristina; Maerkl, Sebastian J. · 2016

Full title: A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing

Authors: Woodruff, Kristina; Maerkl, Sebastian J.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/127380

Thesis

RECOMBINANT AAV6 GENE THERAPY VECTORS: PROCESS OPTIMIZATION AND SCALE UP INTO THE iCELLis NANO BIOREACTOR

Borges, Gwynneth · 2021

Full title: RECOMBINANT AAV6 GENE THERAPY VECTORS: PROCESS OPTIMIZATION AND SCALE UP INTO THE iCELLis NANO BIOREACTOR

Authors: Borges, Gwynneth

DOI: http://jhir.library.jhu.edu/handle/1774.2/63567

Thesis

Comparison of CRISPR/Cas Endonucleases for in vivo Retinal Gene Editing

Li, F; Wing, K; Wang, JH et al. · 2020

Full title: Comparison of CRISPR/Cas Endonucleases for in vivo Retinal Gene Editing

Authors: Li, F; Wing, K; Wang, JH; Luu, CD; Bender, JA; Chen, J; Wang, Q; Lu, Q; Nguyen Tran, MT; Young, KM; Wong, RCB; Pébay, A; Cook, AL; Hung, SSC; Liu, GS; Hewitt, AW

DOI: https://hdl.handle.net/11343/251585

Thesis

The effect of cell penetrating peptides on transfection activity and cytotoxicity of polyallylamine

Sabouri-Rad, S; Oskuee, RK; Mahmoodi, A et al. · 2021

Full title: The effect of cell penetrating peptides on transfection activity and cytotoxicity of polyallylamine

Authors: Sabouri-Rad, S; Oskuee, RK; Mahmoodi, A; Gholami, L; Malaekeh-Nikouei, B

DOI: https://hdl.handle.net/11343/277463

Thesis

Development of an efficient, non-viral transfection method for studying gene function and bone growth in human primary cranial suture mesenchymal cells reveals that the cells respond to BMP2 and BMP3

Dwivedi, PP; Anderson, PJ; Powell, BC · 2022

Authors: Dwivedi, PP; Anderson, PJ; Powell, BC

DOI: https://hdl.handle.net/11343/304511

Thesis

Transduktion av plasmid-komplex genom cellmembran med hjälp av akustofluidisk infångning

Eriksson, John · 2024

Full title: Transduktion av plasmid-komplex genom cellmembran med hjälp av akustofluidisk infångning

Authors: Eriksson, John

DOI: http://lup.lub.lu.se/student-papers/record/9162786

Thesis

Generation of stable suspension producer cell lines for serum-free lentivirus production

Klimpel, M; Terrao, M; Bräuer, M et al. · 2024

Full title: Generation of stable suspension producer cell lines for serum-free lentivirus production

DOI: https://hdl.handle.net/11343/351064

Thesis

AAV capsid bioengineering in primary human retina models

Westhaus, A; Eamegdool, SS; Fernando, M et al. · 2024

Full title: AAV capsid bioengineering in primary human retina models

DOI: https://hdl.handle.net/11343/344430

Thesis

Development of an Improved Transient Triple Transfection System with Focus on Engineering the Helper Plasmid for Enhanced rAAV Production

Pohle, Thilo · 2023

Full title: Development of an Improved Transient Triple Transfection System with Focus on Engineering the Helper Plasmid for Enhanced rAAV Production

Authors: Pohle, Thilo

DOI: https://etheses.whiterose.ac.uk/id/eprint/35606/1/PhDThesis_THP_final.pdf

Thesis

Improving AAV Retinal Gene Therapy for Batten Disease

Schwartz, Maura Katherine · 2022

Full title: Improving AAV Retinal Gene Therapy for Batten Disease

Authors: Schwartz, Maura Katherine

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1669911156168454

Thesis

Characterisation of cellular responses and gene delivery capabilities within porous agarose scaffolds

Sullivan, Matthew Scott · 2024

Full title: Characterisation of cellular responses and gene delivery capabilities within porous agarose scaffolds

Authors: Sullivan, Matthew Scott

DOI: https://etheses.whiterose.ac.uk/id/eprint/35132/1/M%20S%20Sullivan%202024.pdf

Thesis

Non-viral gene delivery with pH-sensitive gemini nanoparticles : synthesis of gemini surfactant building blocks, characterization and in vitro screening of transfection efficiency and toxicity

Donkuru, McDonald · 2009

Authors: Donkuru, McDonald

DOI: http://hdl.handle.net/10388/etd-01132009-131423

Thesis

Optimalizace kultivačního média HEK293 buněčné linie

Čuperková, Romana · 2017

Full title: Optimalizace kultivačního média HEK293 buněčné linie

Authors: Čuperková, Romana

DOI: http://hdl.handle.net/20.500.11956/45606

Thesis

Genome engineering in vivo for modeling of human diseases enhanced by AVV technology

Nickl, Petr · 2025

Full title: Genome engineering in vivo for modeling of human diseases enhanced by AVV technology

Authors: Nickl, Petr

DOI: http://hdl.handle.net/20.500.11956/196257

Thesis

Možné přístupy k terapii cystické fibrosy

Král, Jan · 2019

Full title: Možné přístupy k terapii cystické fibrosy

Authors: Král, Jan

DOI: http://hdl.handle.net/20.500.11956/97888

Thesis

Vývoj techniky pro transfer genů do T-lymfocytů pomocí polyomavirových struktur a peptidu LAH4

Schreiberová, Lucie · 2020

Full title: Vývoj techniky pro transfer genů do T-lymfocytů pomocí polyomavirových struktur a peptidu LAH4

Authors: Schreiberová, Lucie

DOI: http://hdl.handle.net/20.500.11956/122022

Thesis

Optimalizace expresního systému HEK293 buněčné linie pomocí regulace buněčného cyklu a apoptózy

Poláchová, Edita · 2017

Full title: Optimalizace expresního systému HEK293 buněčné linie pomocí regulace buněčného cyklu a apoptózy

Authors: Poláchová, Edita

DOI: http://hdl.handle.net/20.500.11956/68567

Thesis

Study of transposon-mediated cell pool and cell line generation in CHO cells

Balasubramanian, Sowmya · 2015

Full title: Study of transposon-mediated cell pool and cell line generation in CHO cells

Authors: Balasubramanian, Sowmya

DOI: https://infoscience.epfl.ch/handle/20.500.14299/113896

Thesis

Establishment of recombinant mammalian cell lines : new approaches

Derouazi, Madiha · 2005

Full title: Establishment of recombinant mammalian cell lines : new approaches

Authors: Derouazi, Madiha

DOI: https://infoscience.epfl.ch/handle/20.500.14299/212504

Thesis

Correlation between cell cycle and calcium phosphate transient transfection of CHO cells

Grosjean, Frédéric · 2005

Full title: Correlation between cell cycle and calcium phosphate transient transfection of CHO cells

Authors: Grosjean, Frédéric

DOI: https://infoscience.epfl.ch/handle/20.500.14299/211990

Thesis

Transient gene expression for rapid protein production : studies & optimizations under serum-free conditions

Muller, Natalie · 2005

Full title: Transient gene expression for rapid protein production : studies & optimizations under serum-free conditions

Authors: Muller, Natalie

DOI: https://infoscience.epfl.ch/handle/20.500.14299/214287

Thesis

CELL ENGINEERING AND CULTURE MEDIA MODIFICATION STUDIES TO IMPROVE THE CELL CULTURE PERFORMANCE

Dhara, Venkata Gayatri · 2019

Full title: CELL ENGINEERING AND CULTURE MEDIA MODIFICATION STUDIES TO IMPROVE THE CELL CULTURE PERFORMANCE

Authors: Dhara, Venkata Gayatri

DOI: http://jhir.library.jhu.edu/handle/1774.2/60428

Thesis

Expressão gênica empregando pseudopartículas em células de mamíferos (HEK 293T e Huh 7.0) cultivadas em diferentes meios de cultura livres de soro

Jorge, Soraia Attie Calil · 2016

Full title: Expressão gênica empregando pseudopartículas em células de mamíferos (HEK 293T e Huh 7.0) cultivadas em diferentes meios de cultura livres de soro

Authors: Jorge, Soraia Attie Calil

DOI: http://www.teses.usp.br/teses/disponiveis/87/87131/tde-24082016-113658/

Thesis

Optimisation and Application of Nanoelectroporation for Clonal β-Cell Transfection

Ekstrand, Frida · 2025

Full title: Optimisation and Application of Nanoelectroporation for Clonal β-Cell Transfection

Authors: Ekstrand, Frida

DOI: https://lup.lub.lu.se/record/097ab391-be95-4cc3-b370-b1ea33b8a03d

Thesis

Identifizierung und Optimierung kritischer Schritte bei der Transfektion eukaryontischer Zellen

Schurig, Michael · 2009

Full title: Identifizierung und Optimierung kritischer Schritte bei der Transfektion eukaryontischer Zellen

Authors: Schurig, Michael

DOI: https://mediatum.ub.tum.de/667447

Thesis

Optmierung des Gentransfers in humane Keratinozyten mittels rekombinanter Adeno-assoziierter Virus Vektoren

Eisenried, Angelika · 2007

Full title: Optmierung des Gentransfers in humane Keratinozyten mittels rekombinanter Adeno-assoziierter Virus Vektoren

Authors: Eisenried, Angelika

DOI: https://mediatum.ub.tum.de/620611

Thesis

Molecular characterization of the avian adeno-associated virus and its use for the development of a viral vector system

Estevez, Carlos · 2024

Full title: Molecular characterization of the avian adeno-associated virus and its use for the development of a viral vector system

Authors: Estevez, Carlos

DOI: https://openscholar.uga.edu/record/9951/files/estevez_carlos_n_200405_phd.pdf

Thesis

Gene modification and biotechnological applications of mesenchymal stem cells

Bosch, Pablo · 2024

Full title: Gene modification and biotechnological applications of mesenchymal stem cells

Authors: Bosch, Pablo

DOI: https://openscholar.uga.edu/record/20238/files/bosch_pablo_200508_phd.pdf

Thesis

The design, development and characterization of a self-replicating DNA expression technology

de Moor, Warren Ralph Josephus · 2022

Full title: The design, development and characterization of a self-replicating DNA expression technology

Authors: de Moor, Warren Ralph Josephus

DOI: http://hdl.handle.net/11427/36847

Thesis

Untersuchungen zum Gentransfer in die Lunge mittels nicht-viraler Pulveraerosole und viraler Vektoren basierend auf dem Adeno-assoziierten Virus (AAV) 2/9

Pfeifer, Corinna · 2011

Full title: Untersuchungen zum Gentransfer in die Lunge mittels nicht-viraler Pulveraerosole und viraler Vektoren basierend auf dem Adeno-assoziierten Virus (AAV) 2/9

Authors: Pfeifer, Corinna

DOI: https://refubium.fu-berlin.de/handle/fub188/6992

Thesis

Evaluierung von Nukleoprotein-kodierenden AAV Vektoren als breitenwirksame Influenza-Impfstoffe

Fiddeke, Katharina · 2017

Full title: Evaluierung von Nukleoprotein-kodierenden AAV Vektoren als breitenwirksame Influenza-Impfstoffe

Authors: Fiddeke, Katharina

DOI: https://refubium.fu-berlin.de/handle/fub188/8958

Thesis

Herstellung optimierter Sf9-Zelllinien für die Baculovirus-basierte Produktion rekombinanter AAV5-Vektoren mit hoher Infektiosität

Casteleyn, Vincent · 2022

Full title: Herstellung optimierter Sf9-Zelllinien für die Baculovirus-basierte Produktion rekombinanter AAV5-Vektoren mit hoher Infektiosität

Authors: Casteleyn, Vincent

DOI: https://refubium.fu-berlin.de/handle/fub188/33543

Thesis

Adeno-Associated Virus Vectors for Gene Therapy

Mietzsch, Mario · 2014

Full title: Adeno-Associated Virus Vectors for Gene Therapy

Authors: Mietzsch, Mario

DOI: https://refubium.fu-berlin.de/handle/fub188/6047

Thesis

Advances in crustacean cell culture

Claydon, Kerry · 2009

Full title: Advances in crustacean cell culture

Authors: Claydon, Kerry

DOI: https://researchonline.jcu.edu.au/11946/11/JCU_11946_Claydon_2009_thesis.pdf

Thesis

Correcting CPS1 Deficiency in Primary Human Hepatocytes In Vivo Using AAV Delivered Cell-Cycle Independent Targeted Genome Editing

Christina, Sharntie · 2024

Full title: Correcting CPS1 Deficiency in Primary Human Hepatocytes In Vivo Using AAV Delivered Cell-Cycle Independent Targeted Genome Editing

Authors: Christina, Sharntie

DOI: https://hdl.handle.net/2123/32857

Thesis

Improving the immunogenicity of recombinant adeno-associated virus

Ussher, James Edgeworth · 2010

Full title: Improving the immunogenicity of recombinant adeno-associated virus

Authors: Ussher, James Edgeworth

DOI: https://hdl.handle.net/2292/6030

Thesis

Adeno-Associated Virus Gene Therapy For Maple Syrup Urine Disease

Mullany, Kathryn Louise · 2025

Full title: Adeno-Associated Virus Gene Therapy For Maple Syrup Urine Disease

Authors: Mullany, Kathryn Louise

DOI: https://hdl.handle.net/2123/34263

Thesis

Endogenous UMIs as quantifiable reporter elements – validation studies & applications in rAAV vectorology

Wilmott, Patrick Gurney · 2023

Full title: Endogenous UMIs as quantifiable reporter elements – validation studies & applications in rAAV vectorology

Authors: Wilmott, Patrick Gurney

DOI: https://hdl.handle.net/2123/31622

Thesis

The development of viral vectors for targeted gene delivery to atherosclerotic plaques

White, Katie · 2007

Full title: The development of viral vectors for targeted gene delivery to atherosclerotic plaques

Authors: White, Katie

DOI: https://theses.gla.ac.uk/30729/1/2007WhitePhD.pdf

Thesis

Conception et évaluation d’un nouveau système de transfection ciblée, basé sur l’utilisation du système E/Kcoil

Louvier, Elodie · 2016

Full title: Conception et évaluation d’un nouveau système de transfection ciblée, basé sur l’utilisation du système E/Kcoil

Authors: Louvier, Elodie

DOI: http://hdl.handle.net/1866/13031

Thesis

Evaluation of safety and methods for production of retroviral vectors for use in gene therapy

Kewney, Caroline · 1998

Full title: Evaluation of safety and methods for production of retroviral vectors for use in gene therapy

Authors: Kewney, Caroline

DOI: https://theses.gla.ac.uk/71502/7/10391130.pdf

Thesis

Développement de procédés efficaces pour la construction et la production de vecteurs adénoviraux

Gagnon, David · 2010

Full title: Développement de procédés efficaces pour la construction et la production de vecteurs adénoviraux

Authors: Gagnon, David

DOI: http://hdl.handle.net/1866/4462

Thesis

A study of apoptosis and cell cycle to augment transfection efficiency in CHO cell lines

Wanandy, Nico Stanislaus · 2007

Full title: A study of apoptosis and cell cycle to augment transfection efficiency in CHO cell lines

Authors: Wanandy, Nico Stanislaus

DOI: http://hdl.handle.net/1959.4/40868

Thesis

Epi-CHO, an episomal expression system for recombinant protein production in CHO cells

Kunaparaju, Raj Kumar · 2008

Full title: Epi-CHO, an episomal expression system for recombinant protein production in CHO cells

Authors: Kunaparaju, Raj Kumar

DOI: http://hdl.handle.net/1959.4/41499

Thesis

Preparation and functionalization of magnetic iron oxide nanoparticles for application in gene delivery

Arsianti, Maria · 2010

Full title: Preparation and functionalization of magnetic iron oxide nanoparticles for application in gene delivery

Authors: Arsianti, Maria

DOI: http://hdl.handle.net/1959.4/50261

Thesis

Production de vecteurs viraux efficaces pour la transduction de cellules transformées et de cellules primaires

Pilotte, Amélie · 2016

Full title: Production de vecteurs viraux efficaces pour la transduction de cellules transformées et de cellules primaires

Authors: Pilotte, Amélie

DOI: http://hdl.handle.net/1866/15572

Thesis

Retroviral transduction of hematopoietic stem cells : optimisation of parameters for transduction

Wotherspoon, Simon Lance · 2005

Full title: Retroviral transduction of hematopoietic stem cells : optimisation of parameters for transduction

Authors: Wotherspoon, Simon Lance

DOI: http://hdl.handle.net/1959.4/66240

Thesis

Development and optimization of the attB system to produce Helper-dependent Adenovirus vectors of different species

Cots i Rabella, Dan · 2014

Full title: Development and optimization of the attB system to produce Helper-dependent Adenovirus vectors of different species

Authors: Cots i Rabella, Dan

DOI: http://hdl.handle.net/10803/283431

Thesis

Enhancement of virus-like particle production in HEK293 cell cultures

Fuenmayor Garcés, Javier · 2018

Full title: Enhancement of virus-like particle production in HEK293 cell cultures

Authors: Fuenmayor Garcés, Javier

DOI: http://hdl.handle.net/10803/650410

Thesis

Study and characterisation of human HEK293 cell line as a platform for recombinant protein production

Liste Calleja, Leticia · 2015

Full title: Study and characterisation of human HEK293 cell line as a platform for recombinant protein production

Authors: Liste Calleja, Leticia

DOI: http://hdl.handle.net/10803/308324

Thesis

Production of Virus-Like Particles in HEK 293 cells and functionalization with SARS-CoV-2

Boix i Besora, Arnau · 2022

Full title: Production of Virus-Like Particles in HEK 293 cells and functionalization with SARS-CoV-2

Authors: Boix i Besora, Arnau

DOI: http://hdl.handle.net/10803/675518

Thesis

Bioprocess Engineering for HIV-1 Gag VLP Production in HEK293 Cells

Lavado García, Jesús · 2022

Full title: Bioprocess Engineering for HIV-1 Gag VLP Production in HEK293 Cells

Authors: Lavado García, Jesús

DOI: http://hdl.handle.net/10803/674392

Thesis

Desarrollo de procesos de producción de proteínas bioterapéuticas: Aumento de la productividad especifica en células HEK293

Román Roldán, Ramón · 2018

Full title: Desarrollo de procesos de producción de proteínas bioterapéuticas: Aumento de la productividad especifica en células HEK293

Authors: Román Roldán, Ramón

DOI: http://hdl.handle.net/10803/650828

Thesis

Strategies for improving production levels of HIV-1 VLPs by transient transfection of HEK 293 suspension cultures

Cervera Garcia, Laura · 2015

Full title: Strategies for improving production levels of HIV-1 VLPs by transient transfection of HEK 293 suspension cultures

Authors: Cervera Garcia, Laura

DOI: http://hdl.handle.net/10803/289626

Thesis

Understanding the cell density effect upon transient transfection in HEK293 cell culture during HIV-1 VLP production

Pérez Rubio, Pol · 2024

Full title: Understanding the cell density effect upon transient transfection in HEK293 cell culture during HIV-1 VLP production

Authors: Pérez Rubio, Pol

DOI: http://hdl.handle.net/10803/693156

Thesis

LARGE GENE DELIVERY TO THE RETINA BY MULTIPLE AAV VECTORS

TORNABENE, PATRIZIA · 2019

Full title: LARGE GENE DELIVERY TO THE RETINA BY MULTIPLE AAV VECTORS

Authors: TORNABENE, PATRIZIA

DOI: http://hdl.handle.net/2434/608611

Thesis

Geração de clones de células HEK293 superprodutores de isoformas recombinantes de VEGF-A (Fator de Crescimento Endotelial Vascular A) humano visando à produção de biofármacos para terapia molecular e engenharia tecidual

Sogayar, Mari Cleide · 2014

Authors: Sogayar, Mari Cleide

DOI: http://www.teses.usp.br/teses/disponiveis/46/46131/tde-01102014-145602/

Thesis

A novel AAV9 random peptide library to select for endothelial cell – directed gene transfer vectors

Varadi, Karl · 2011

Full title: A novel AAV9 random peptide library to select for endothelial cell – directed gene transfer vectors

Authors: Varadi, Karl

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/12542/1/Dissertation_Karl_Varadi.pdf

Thesis

Analysis of Infection Relevant Protein Domains of the Adeno-Associated Virus Serotype 8 in Comparison to Serotype 2

Raupp, Christina · 2010

Full title: Analysis of Infection Relevant Protein Domains of the Adeno-Associated Virus Serotype 8 in Comparison to Serotype 2

Authors: Raupp, Christina

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/10925/1/complete_CRAUPPdiss.pdf

Thesis

Alleviation of shRNA off-target effects via rAAV vector-encoded sense strand decoys

Mockenhaupt, Stefan · 2012

Full title: Alleviation of shRNA off-target effects via rAAV vector-encoded sense strand decoys

Authors: Mockenhaupt, Stefan

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/13390/1/Mockenhaupt_PhD_thesis_final.pdf

Thesis

With small viruses come giant responsibilities - Next-generation parvoviral vectors for human gene therapy with extended packaging capacity and enhanced safety profile

Fakhiri, Julia · 2019

Full title: With small viruses come giant responsibilities - Next-generation parvoviral vectors for human gene therapy with extended packaging capacity and enhanced safety profile

Authors: Fakhiri, Julia

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/27326/1/PhD%20thesis%20Julia%20Fakhiri.pdf

Thesis

Evaluating Lung Gene Therapy Viral Vector Platforms using Precision-cut Lung Slices as an ex vivo Model

Stevens, Brenna · 2025

Full title: Evaluating Lung Gene Therapy Viral Vector Platforms using Precision-cut Lung Slices as an ex vivo Model

Authors: Stevens, Brenna

DOI: https://hdl.handle.net/10214/29367

Thesis

Glyco-engineered HEK 293-F cell lines to produce therapeutic glycoproteins with human N-glycosylation and improved pharmacokinetics

Uhler, Rico · 2022

Full title: Glyco-engineered HEK 293-F cell lines to produce therapeutic glycoproteins with human N-glycosylation and improved pharmacokinetics

Authors: Uhler, Rico

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/31087/1/PhD%20Thesis%20Rico%20Uhler.pdf

Thesis

Charakterisierung eines parvoviralen Hybridvektors hinsichtlich der Transduktion und präferentiellen Expression in transformierten Zellen

Krüger, Lars · 2005

Full title: Charakterisierung eines parvoviralen Hybridvektors hinsichtlich der Transduktion und präferentiellen Expression in transformierten Zellen

Authors: Krüger, Lars

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/5635/1/Dissertation_LK.pdf

Thesis

Targeted lentiviral vectors pseudotyped with the Tupaia paramyxovirus glycoproteins

Enkirch, Theresa · 2011

Full title: Targeted lentiviral vectors pseudotyped with the Tupaia paramyxovirus glycoproteins

Authors: Enkirch, Theresa

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/12946/1/DrArbeit_FINAL_Theresa.pdf

Thesis

One for all, all for one: Combining and improving AAV, RNAi and CRISPR technologies to combat HBV infection and HBV/HDV co-infections

Schmelas, Carolin · 2020

Full title: One for all, all for one: Combining and improving AAV, RNAi and CRISPR technologies to combat HBV infection and HBV/HDV co-infections

Authors: Schmelas, Carolin

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/28513/1/Schmelas_Dissertation.pdf

Thesis

Rekombinante Hepatitis B Viren-Vektoren als Werkzeuge für Molekularbiologie und Therapie : Optimierung eines Systems

Untergasser, Andreas · 2003

Full title: Rekombinante Hepatitis B Viren-Vektoren als Werkzeuge für Molekularbiologie und Therapie : Optimierung eines Systems

Authors: Untergasser, Andreas

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/3121/1/Promotion.pdf

Thesis

Engineering inducible cell lines for recombinant Adeno-Associated Virus production

Lee, Zion · 2021

Full title: Engineering inducible cell lines for recombinant Adeno-Associated Virus production

Authors: Lee, Zion

DOI: https://hdl.handle.net/11299/225020

Thesis

Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Murayyan, Abdulmonem · 2013

Full title: Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Authors: Murayyan, Abdulmonem

DOI: http://hdl.handle.net/10214/6604

Thesis

AAV-Vectored Immunoprophylaxis for the Prevention and Treatment of Infectious Diseases

Rghei, Amira · 2022

Full title: AAV-Vectored Immunoprophylaxis for the Prevention and Treatment of Infectious Diseases

Authors: Rghei, Amira

DOI: https://hdl.handle.net/10214/27116

Thesis

Optimizing an Adeno-Associated Virus Vector System for Monogenic Diseases: Promoter Discovery and In Vivo Dosing Insights from a Neonatal Pig Model

Zielinska, Nicole · 2025

Full title: Optimizing an Adeno-Associated Virus Vector System for Monogenic Diseases: Promoter Discovery and In Vivo Dosing Insights from a Neonatal Pig Model

Authors: Zielinska, Nicole

DOI: https://hdl.handle.net/10214/29254

Thesis

Adeno-Associated Virus Vector Development for Monoclonal Antibody Expression to Prevent Ebola Virus Infection

van Lieshout, Laura · 2018

Full title: Adeno-Associated Virus Vector Development for Monoclonal Antibody Expression to Prevent Ebola Virus Infection

Authors: van Lieshout, Laura

DOI: http://hdl.handle.net/10214/14680

Thesis

Novel Extracellular Vesicle Modalities for Delivery of Genome Editor Ribonucleoprotein Complexes

Cabeceiras, Peter Keith · 2022

Full title: Novel Extracellular Vesicle Modalities for Delivery of Genome Editor Ribonucleoprotein Complexes

Authors: Cabeceiras, Peter Keith

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372269

Thesis

Factors affecting AAV production: Mutagenesis of AAV2 rep and AAV transgenes

Jain, Nina Kumari · 2024

Full title: Factors affecting AAV production: Mutagenesis of AAV2 rep and AAV transgenes

Authors: Jain, Nina Kumari

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37377871

Thesis

Novel High-Throughput Methods to Study AAV Immunity Using Combinatorial Capsid Libraries

Schmit, Pauline Frances · 2021

Full title: Novel High-Throughput Methods to Study AAV Immunity Using Combinatorial Capsid Libraries

Authors: Schmit, Pauline Frances

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369455

Thesis

Advanced Process Development in Gene and Cell Therapies

Ladd, Brian · 2025

Full title: Advanced Process Development in Gene and Cell Therapies

Authors: Ladd, Brian

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-360154

Thesis

Structural, Viral, and Host Factors of Adeno-Associated Virus Assembly

Maurer, Anna · 2019

Full title: Structural, Viral, and Host Factors of Adeno-Associated Virus Assembly

Authors: Maurer, Anna

DOI: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42029713

Thesis

In Vivo Delivery and Therapeutic Applications of Base Editors

Yeh, Ariel (Wei-Hsi) · 2020

Full title: In Vivo Delivery and Therapeutic Applications of Base Editors

Authors: Yeh, Ariel (Wei-Hsi)

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37365751

Thesis

Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis

Production and pharmaceutical formulation of plasmid DNA vaccines

van der Heijden, I. · 2013

Full title: Production and pharmaceutical formulation of plasmid DNA vaccines

Authors: van der Heijden, I.

DOI: https://dspace.library.uu.nl/handle/1874/283165

Thesis

Formulation and delivery of dermal DNA vaccines

van den Berg, J.H. · 2009

Full title: Formulation and delivery of dermal DNA vaccines

Authors: van den Berg, J.H.

DOI: https://dspace.library.uu.nl/handle/1874/36212

Thesis

Highly efficient Cas9 mediated transcriptional programming and delivery via Adeno-Associated Virus

Vora, Suhani · 2017

Full title: Highly efficient Cas9 mediated transcriptional programming and delivery via Adeno-Associated Virus

Authors: Vora, Suhani

DOI: http://hdl.handle.net/1721.1/112508

Thesis

Systems Engineering for Viral Vector Manufacturing

Nguyen, Tam Ngoc Thanh · 2023

Full title: Systems Engineering for Viral Vector Manufacturing

Authors: Nguyen, Tam Ngoc Thanh

DOI: https://hdl.handle.net/1721.1/150243

Thesis

Efficacy and toxicity of linear polyamidoamine polymers used in gene delivery

Almulathanon, Ammar · 2018

Full title: Efficacy and toxicity of linear polyamidoamine polymers used in gene delivery

Authors: Almulathanon, Ammar

DOI: https://eprints.nottingham.ac.uk/49894/1/Ammar%20thesis.pdf

Thesis

Quantitative analysis of non-viral gene therapy in primary liver culture systems

Tedford, Nathan C · 2008

Full title: Quantitative analysis of non-viral gene therapy in primary liver culture systems

Authors: Tedford, Nathan C

DOI: http://hdl.handle.net/1721.1/39914

Thesis

Optimisation of Delivery of the Ataxia Telangiectasia Mutated Transgene to HeLa Cells Using Glycosaminoglycan Enhanced Transduction

Siam, Ala'a · 2021

Full title: Optimisation of Delivery of the Ataxia Telangiectasia Mutated Transgene to HeLa Cells Using Glycosaminoglycan Enhanced Transduction

Authors: Siam, Ala'a

DOI: https://eprints.nottingham.ac.uk/66891/1/Ala%27a%20Siam%20-%20MRes%20Thesis.pdf

Thesis

Modified cell penetrating peptides for efficient gene transfer in vitro and in vivo

Osman, Gizem · 2017

Full title: Modified cell penetrating peptides for efficient gene transfer in vitro and in vivo

Authors: Osman, Gizem

DOI: https://eprints.nottingham.ac.uk/41863/1/00%20MASTER%20-%20G.Osman.pdf

Thesis

Scalable Production of Genome-Edited Livestock Embryos

Lin, Jason Chen · 2022

Full title: Scalable Production of Genome-Edited Livestock Embryos

Authors: Lin, Jason Chen

DOI: https://escholarship.org/uc/item/8hs7x39z

Thesis

Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Cosenza, Zachary Anthony · 2022

Full title: Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Authors: Cosenza, Zachary Anthony

DOI: https://escholarship.org/uc/item/119489fc

Thesis

Construction and characterization of stable cell lines that generate recombinant adeno-associated virus (rAAV) /

Voulgaropoulou, Frosso · 1996

Full title: Construction and characterization of stable cell lines that generate recombinant adeno-associated virus (rAAV) /

Authors: Voulgaropoulou, Frosso

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1487942476408687

Thesis

Genetic Modification of Adeno-Associated Virus Capsid for Enhanced Motor Neuron Delivery and Retrograde Transport

Davis, Adam Scott · 2012

Full title: Genetic Modification of Adeno-Associated Virus Capsid for Enhanced Motor Neuron Delivery and Retrograde Transport

Authors: Davis, Adam Scott

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1351693788

Thesis

White-Box Approaches to Cell Culture Media Optimization for Cultivated Meat

O'Neill, Edward N · 2024

Full title: White-Box Approaches to Cell Culture Media Optimization for Cultivated Meat

Authors: O'Neill, Edward N

DOI: https://escholarship.org/uc/item/9920t5d7

Thesis

Derivation of rep-positive adeno-associated virus vectors and analysis of site-specific integration /

Philpott, Jessica R. · 2000

Full title: Derivation of rep-positive adeno-associated virus vectors and analysis of site-specific integration /

Authors: Philpott, Jessica R.

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1488192119261715

Thesis

Identification and Validation of Target Receptors/Transporters for AAV9

Roach, Matthew · 2023

Full title: Identification and Validation of Target Receptors/Transporters for AAV9

Authors: Roach, Matthew

DOI: https://etheses.whiterose.ac.uk/id/eprint/33782/1/MatthewRoach_PhD_Thesis_with_corrections_MR%20edit.pdf

Thesis

Development of new strategies for efficient production and purification of recombinant adeno-associated virus (rAAV) vector /

Liu, Xingluo · 1999

Full title: Development of new strategies for efficient production and purification of recombinant adeno-associated virus (rAAV) vector /

Authors: Liu, Xingluo

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1488187049541563

Thesis

Optimising adeno associated virus mediated gene therapy

Mallik, Shreyashee · 2023

Full title: Optimising adeno associated virus mediated gene therapy

Authors: Mallik, Shreyashee

DOI: https://hdl.handle.net/2123/31477

Thesis

Development and characterization of an improved formulation of cholesteryl oleate-loaded cationic solid-lipid nanoparticles as an efficient non-viral gene delivery system

Limeres, María José; Suñé-Pou, Marc; Prieto-Sánchez, Silvia et al. · 2019

Full title: Development and characterization of an improved formulation of cholesteryl oleate-loaded cationic solid-lipid nanoparticles as an efficient non-viral gene delivery system

DOI: http://sedici.unlp.edu.ar/handle/10915/139683

Thesis

Produção de vetores lentivirais baseados em HIV-1 em linhagem de célula tronco mesenquimal murina

Silva, Flávia Helena da · 2007

Full title: Produção de vetores lentivirais baseados em HIV-1 em linhagem de célula tronco mesenquimal murina

Authors: Silva, Flávia Helena da

DOI: http://hdl.handle.net/10183/8134

Thesis

Design of a Novel Gene Therapy Construct to Achieve Sustained Brain-Derived Neurotrophic Factor Signaling in Neurons.

Osborne, Andrew; Wang, Aiden XZ; Tassoni, Alessia et al. · 2018

Full title: Design of a Novel Gene Therapy Construct to Achieve Sustained Brain-Derived Neurotrophic Factor Signaling in Neurons.

Authors: Osborne, Andrew; Wang, Aiden XZ; Tassoni, Alessia; Widdowson, Peter S; Martin, Keith R

DOI: https://www.repository.cam.ac.uk/handle/1810/274008

Thesis

Adeno-associated virus rep78 expression in Arabidopsis thaliana

Sisco, Daniel · 2011

Full title: Adeno-associated virus rep78 expression in Arabidopsis thaliana

Authors: Sisco, Daniel

DOI: http://hdl.handle.net/10919/9706

Thesis

A Mechanistic Dissection of Polyethylenimine Mediated Transfection of Chinese Hamster Ovary Cells

Mozley, O L · 2013

Full title: A Mechanistic Dissection of Polyethylenimine Mediated Transfection of Chinese Hamster Ovary Cells

Authors: Mozley, O L

DOI: https://etheses.whiterose.ac.uk/id/eprint/5593/1/A%20mechanistic%20dissection%20of%20polyethylenimine%20mediated%20transfection%20of%20chinese%20hamster%20ovary%20cells.pdf

Thesis

Optimalizace rekombinantní exprese proteinů v lidské buněčné linii HEK293

Murajdová, Viktória · 2024

Full title: Optimalizace rekombinantní exprese proteinů v lidské buněčné linii HEK293

Authors: Murajdová, Viktória

DOI: http://hdl.handle.net/20.500.11956/194250

Thesis

Transient recombinant protein expression in mammalian cells : the role of mRNA level and stability

Wulhfard, Sarah · 2009

Full title: Transient recombinant protein expression in mammalian cells : the role of mRNA level and stability

Authors: Wulhfard, Sarah

DOI: https://infoscience.epfl.ch/handle/20.500.14299/36998

Thesis

DEAE-Dextran Enhances the Lentiviral Transduction of Primary Human Mesenchymal Stromal Cells from All Major Tissue Sources Without Affecting Their Proliferation and Phenotype

Amadeo, Francesco; Hanson, Vivien; Murray, Patricia et al. · 2023

Full title: DEAE-Dextran Enhances the Lentiviral Transduction of Primary Human Mesenchymal Stromal Cells from All Major Tissue Sources Without Affecting Their Proliferation and Phenotype

Authors: Amadeo, Francesco; Hanson, Vivien; Murray, Patricia; Taylor, Arthur

DOI: https://livrepository.liverpool.ac.uk/3162174/1/library.pdf

Thesis

Untersuchung der zellspezifischen In-situ-Effizienz des Nukleinsäuretransfers in das Herzgewebe

Liu, Zihou · 2021

Full title: Untersuchung der zellspezifischen In-situ-Effizienz des Nukleinsäuretransfers in das Herzgewebe

Authors: Liu, Zihou

DOI: https://refubium.fu-berlin.de/handle/fub188/31132

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