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Monoclonal Antibody Production Optimization In Cho

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Paper ALiCE®: A versatile, high yielding and scalable eukaryotic cell-free protein synthesis (CFPS) system

Mainak das Gupta; Yannick Flaskamp; Robin Roentgen et al. · 2022 · bioRxiv · DOI

Full title: ALiCE®: A versatile, high yielding and scalable eukaryotic cell-free protein synthesis (CFPS) system

Authors: Mainak das Gupta; Yannick Flaskamp; Robin Roentgen; Hannes Juergens; Jorge Armero Gimenez; F. Albrecht; Johannes Hemmerich; Zulfaquar Ahmad Arfi; Jakob Neuser; H. Spiegel; A. Yeliseev; Lusheng Song; J. Qiu; C. Williams; R. Finnern

Year: 2022

Venue: bioRxiv

DOI: https://doi.org/10.1101/2022.11.10.515920

Paper pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis

Adams, Richard R.; Tavares, Álvaro A.; Salzberg, Adi et al. · 1998 · Genes & Development · DOI

Full title: pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis

Authors: Adams, Richard R.; Tavares, Álvaro A.; Salzberg, Adi; Bellen, Hugo J.; Glover, David M.

Year: 1998

Venue: Genes & Development

DOI: https://doi.org/10.1101/gad.12.10.1483

Paper Efficient and reproducible generation of high-expressing, stable human cell lines without need for antibiotic selection

Schiedner, Gudrun; Hertel, Sabine; Bialek, Corinna et al. · 2008 · BMC Biotechnology · DOI

Full title: Efficient and reproducible generation of high-expressing, stable human cell lines without need for antibiotic selection

Authors: Schiedner, Gudrun; Hertel, Sabine; Bialek, Corinna; Kewes, Helmut; Waschütza, Gero; Volpers, Christoph

Year: 2008

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-8-13

Paper Establishment and mitotic stability of an extra-chromosomal mammalian replicon

Stehle, Isa M.; Postberg, Jan; Rupprecht, Sina et al. · 2007 · BMC Cell Biology · DOI

Full title: Establishment and mitotic stability of an extra-chromosomal mammalian replicon

Authors: Stehle, Isa M.; Postberg, Jan; Rupprecht, Sina; Cremer, Thomas; Jackson, Dean A.; Lipps, Hans J.

Year: 2007

Venue: BMC Cell Biology

DOI: https://doi.org/10.1186/1471-2121-8-33

Paper Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0

Teylaert, Béatrice; Meurice, Edwige; Bobowski, Marie et al. · 2011 · BMC Biotechnology · DOI

Full title: Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0

Authors: Teylaert, Béatrice; Meurice, Edwige; Bobowski, Marie; Harduin‐Lepers, Anne; Gaucher, Christine; Fontayne, Alexandre; Jorieux, Sylvie; Delannoy, Philippe

Year: 2011

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-11-1

Paper Fluorescent labeling in semi-solid medium for selection of mammalian cells secreting high-levels of recombinant proteins

Caron, Antoine W.; Nicolas, Claire; Gaillet, Bruno et al. · 2009 · BMC Biotechnology · DOI

Full title: Fluorescent labeling in semi-solid medium for selection of mammalian cells secreting high-levels of recombinant proteins

Authors: Caron, Antoine W.; Nicolas, Claire; Gaillet, Bruno; Ba, Ismaïla; Pinard, Maxime; Garnier, Alain; Massie, Bernard; Gilbert, Rénald

Year: 2009

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-9-42

Paper Generation and characterization of a new mammalian cell line continuously expressing virus-like particles of Japanese encephalitis virus for a subunit vaccine candidate

Hua, Rong-Hong; Li, Yenan; Chen, Zhenshi et al. · 2014 · BMC Biotechnology · DOI

Full title: Generation and characterization of a new mammalian cell line continuously expressing virus-like particles of Japanese encephalitis virus for a subunit vaccine candidate

Authors: Hua, Rong-Hong; Li, Yenan; Chen, Zhenshi; Liu, Like; Huo, Hong; Wang, Xiaolei; Guo, Liping; Shen, Nan; Wang, Jingfei; Bu, Zhigao

Year: 2014

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-14-62

Paper Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

Imai-Nishiya, Harue; Mori, Katsuhiro; Inoue, Miho et al. · 2007 · BMC Biotechnology · DOI

Full title: Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

Authors: Imai-Nishiya, Harue; Mori, Katsuhiro; Inoue, Miho; Wakitani, Masako; Iida, Shigeru; Shitara, Kenya; Satoh, Mitsuo

Year: 2007

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-7-84

Paper Generation of diploid Pichia pastoris strains by mating and their application for recombinant protein production

Chen, Ming‐Tang; Lin, Song; Shandil, Ishaan et al. · 2012 · Microbial Cell Factories · DOI

Full title: Generation of diploid Pichia pastoris strains by mating and their application for recombinant protein production

Authors: Chen, Ming‐Tang; Lin, Song; Shandil, Ishaan; Andrews, Dewan; Stadheim, Terrance A.; Choi, Byung‐Kwon

Year: 2012

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-11-91

Paper Applications of cell sorting in biotechnology

Mattanovich, Diethard; Borth, Nicole · 2006 · Microbial Cell Factories · DOI

Full title: Applications of cell sorting in biotechnology

Authors: Mattanovich, Diethard; Borth, Nicole

Year: 2006

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-5-12

Paper Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies

Chung, Nancy PY; Matthews, Katie; Kim, Helen J. et al. · 2014 · Retrovirology · DOI

Full title: Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies

Authors: Chung, Nancy PY; Matthews, Katie; Kim, Helen J.; Ketas, Thomas J.; Golabek, Michael; Reyes, Kevin de los; Korzun, Jacob; Yasmeen, Anila; Sanders, Rogier W.; Klasse, Per Johan; Wilson, Ian A.; Ward, Andrew B.; Marozsan, Andre J.; Moore, John P.; Cupo, Albert

Year: 2014

Venue: Retrovirology

DOI: https://doi.org/10.1186/1742-4690-11-33

Paper Recombinant protein expression by targeting pre-selected chromosomal loci

Nehlsen, Kristina; Schucht, Roland; Gama-Norton, Leonor et al. · 2009 · BMC Biotechnology · DOI

Full title: Recombinant protein expression by targeting pre-selected chromosomal loci

Authors: Nehlsen, Kristina; Schucht, Roland; Gama-Norton, Leonor; Krömer, W.; Baer, Alexandra; Cayli, Aziz; Häuser, H.; Wirth, Dagmar

Year: 2009

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-9-100

Paper Production and characterization of specific monoclonal antibodies binding the Plasmodium falciparum diagnostic biomarker, histidine-rich protein 2

Leow, Chiuan Yee; Jones, Martina L.; Cheng, Qin et al. · 2014 · Malaria Journal · DOI

Full title: Production and characterization of specific monoclonal antibodies binding the Plasmodium falciparum diagnostic biomarker, histidine-rich protein 2

Authors: Leow, Chiuan Yee; Jones, Martina L.; Cheng, Qin; Mahler, Stephen M.; McCarthy, James

Year: 2014

Venue: Malaria Journal

DOI: https://doi.org/10.1186/1475-2875-13-277

Paper Novel cell engineering of the Unfolded Protein Response to achieve efficient therapeutic protein production cell line

Michael Song; J. Hou; L. Nielsen et al. · 2015 · BMC Proceedings · DOI

Full title: Novel cell engineering of the Unfolded Protein Response to achieve efficient therapeutic protein production cell line

Authors: Michael Song; J. Hou; L. Nielsen; P. Gray

Year: 2015

Venue: BMC Proceedings

DOI: https://doi.org/10.1186/1753-6561-9-s9-p14

Paper Evaluating the expression profile and stability of different UCOE containing vector combinations in mAb-producing CHO cells

Nematpour, Fatemeh Saeid; Mahboudi, Fereidoun; Vaziri, Behrouz et al. · 2017 · BMC Biotechnology · DOI

Full title: Evaluating the expression profile and stability of different UCOE containing vector combinations in mAb-producing CHO cells

Authors: Nematpour, Fatemeh Saeid; Mahboudi, Fereidoun; Vaziri, Behrouz; Khalaj, Vahid; Ahmadi, Samira; Ahmadi, Maryam; Ebadat, Saedeh; Davami, Fatemeh

Year: 2017

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/s12896-017-0330-0

Paper High level transient production of recombinant antibodies and antibody fusion proteins in HEK293 cells

Jäger, Volker; Büssow, Konrad; Wagner, Andreas et al. · 2013 · BMC Biotechnology · DOI

Full title: High level transient production of recombinant antibodies and antibody fusion proteins in HEK293 cells

Authors: Jäger, Volker; Büssow, Konrad; Wagner, Andreas; Weber, Susanne; Hust, Michael; Frenzel, André; Schirrmann, Thomas

Year: 2013

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-13-52

Paper Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell lines

Veith, Nathalie; Ziehr, Holger; MacLeod, Roderick A.F. et al. · 2016 · BMC Biotechnology · DOI

Full title: Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell lines

Authors: Veith, Nathalie; Ziehr, Holger; MacLeod, Roderick A.F.; Reamon-Buettner, Stella Marie

Year: 2016

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/s12896-016-0238-0

Paper Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up

Madhavan, Aravind; Arun, K. B.; Sindhu, Raveendran et al. · 2021 · Microbial Cell Factories · DOI

Full title: Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up

Authors: Madhavan, Aravind; Arun, K. B.; Sindhu, Raveendran; Krishnamoorthy, Jayaram; Reshmy, R.; Sirohi, Ranjna; Pugazhendi, Arivalagan; Awasthi, Mukesh Kumar; Szakács, George; Binod, Parameswaran

Year: 2021

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-021-01617-z

Paper Preclinical development of a novel CD47 nanobody with less toxicity and enhanced anti-cancer therapeutic potential

Ma, Linlin; Zhu, Minmin; Gai, Junwei et al. · 2020 · Journal of Nanobiotechnology · DOI

Full title: Preclinical development of a novel CD47 nanobody with less toxicity and enhanced anti-cancer therapeutic potential

Authors: Ma, Linlin; Zhu, Minmin; Gai, Junwei; Li, Guanghui; Chang, Qing; Peng, Qiao; Cao, Long‐Long; Chen, Wanqing; Zhang, Siyuan; Wan, Yakun

Year: 2020

Venue: Journal of Nanobiotechnology

DOI: https://doi.org/10.1186/s12951-020-0571-2

Paper Screening and selection strategy for the establishment of biosimilar to trastuzumab-expressing CHO-K1 cell lines

Lao, Thailin; Bueno-Soler, Alexi; Durán‐Hernández, Arnelys et al. · 2021 · AMB Express · DOI

Full title: Screening and selection strategy for the establishment of biosimilar to trastuzumab-expressing CHO-K1 cell lines

Authors: Lao, Thailin; Bueno-Soler, Alexi; Durán‐Hernández, Arnelys; Sosa-Aguiar, Katya; Hinojosa-Puerta, Luis Eduardo; Hernández-García, Tays; Luz-Hernández, K.R. de la; Palacios-Oliva, Julio; Boggiano-Ayo, Tammy

Year: 2021

Venue: AMB Express

DOI: https://doi.org/10.1186/s13568-020-01157-6

Paper Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease?

Laustsen, Andreas H.; Johansen, K.; Engmark, Mikael et al. · 2017 · PLoS neglected tropical diseases · DOI

Full title: Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease?

Authors: Laustsen, Andreas H.; Johansen, K.; Engmark, Mikael; Andersen, Mikael Rørdam

Year: 2017

Venue: PLoS neglected tropical diseases

DOI: https://doi.org/10.1371/journal.pntd.0005361

Paper Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G

Miyakawa, Shin; Nomura, Yusuke; Sakamoto, Taiichi et al. · 2008 · RNA · DOI

Full title: Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G

Authors: Miyakawa, Shin; Nomura, Yusuke; Sakamoto, Taiichi; Yamaguchi, Yoshiki; Kato, Koichi; Yamazaki, Satoko; Nakamura, Yoshikazu

Year: 2008

Venue: RNA

DOI: https://doi.org/10.1261/rna.1005808

Paper Intraclonal Protein Expression Heterogeneity in Recombinant CHO Cells

Pilbrough, Warren; Munro, Trent P.; Gray, Peter P. · 2009 · PLoS ONE · DOI

Full title: Intraclonal Protein Expression Heterogeneity in Recombinant CHO Cells

Authors: Pilbrough, Warren; Munro, Trent P.; Gray, Peter P.

Year: 2009

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0008432

Paper SweetBac: A New Approach for the Production of Mammalianised Glycoproteins in Insect Cells

Palmberger, Dieter; Wilson, Iain B. H.; Berger, Imre et al. · 2012 · PLoS ONE · DOI

Full title: SweetBac: A New Approach for the Production of Mammalianised Glycoproteins in Insect Cells

Authors: Palmberger, Dieter; Wilson, Iain B. H.; Berger, Imre; Grabherr, Reingard; Rendić, Dubravko

Year: 2012

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0034226

Paper Efficient Recombinant Production in Mammalian Cells Using a Novel IR/MAR Gene Amplification Method

Araki, Yoshio; Hamafuji, Tetsuro; Noguchi, Chiemi et al. · 2012 · PLoS ONE · DOI

Full title: Efficient Recombinant Production in Mammalian Cells Using a Novel IR/MAR Gene Amplification Method

Authors: Araki, Yoshio; Hamafuji, Tetsuro; Noguchi, Chiemi; Shimizu, Noriaki

Year: 2012

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0041787

Paper Systematic Single-Cell Analysis of Pichia pastoris Reveals Secretory Capacity Limits Productivity

Love, Kerry R.; Politano, Timothy J.; Panagiotou, Vasiliki et al. · 2012 · PLoS ONE · DOI

Full title: Systematic Single-Cell Analysis of Pichia pastoris Reveals Secretory Capacity Limits Productivity

Authors: Love, Kerry R.; Politano, Timothy J.; Panagiotou, Vasiliki; Jiang, Bo; Stadheim, Terrance A.; Love, J. Christopher

Year: 2012

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0037915

Paper Rapid Transient Production in Plants by Replicating and Non-Replicating Vectors Yields High Quality Functional Anti-HIV Antibody

Sainsbury, Frank; Sack, M.; Stadlmann, Johannes et al. · 2010 · PLoS ONE · DOI

Full title: Rapid Transient Production in Plants by Replicating and Non-Replicating Vectors Yields High Quality Functional Anti-HIV Antibody

Authors: Sainsbury, Frank; Sack, M.; Stadlmann, Johannes; Quendler, Heribert; Fischer, Rainer; Lomonossoff, George P.

Year: 2010

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0013976

Paper An Internal Ribosome Entry Site (IRES) Mutant Library for Tuning Expression Level of Multiple Genes in Mammalian Cells

Koh, Esther Y. C.; Ho, Steven C. L.; Mariati et al. · 2013 · PLoS ONE · DOI

Full title: An Internal Ribosome Entry Site (IRES) Mutant Library for Tuning Expression Level of Multiple Genes in Mammalian Cells

Authors: Koh, Esther Y. C.; Ho, Steven C. L.; Mariati; Song, Zhiwei; Bi, Xuezhi; Bardor, Muriel; Yang, Yuansheng

Year: 2013

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0082100

Paper A Multi-Omics Analysis of Recombinant Protein Production in Hek293 Cells

Dietmair, Stefanie; Hodson, Mark P.; Quek, Lake‐Ee et al. · 2012 · PLoS ONE · DOI

Full title: A Multi-Omics Analysis of Recombinant Protein Production in Hek293 Cells

Authors: Dietmair, Stefanie; Hodson, Mark P.; Quek, Lake‐Ee; Timmins, Nicholas; Gray, Peter P.; Nielsen, Lars K.

Year: 2012

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0043394

Paper Fusion of the Dhfr/Mtx and IR/MAR Gene Amplification Methods Produces a Rapid and Efficient Method for Stable Recombinant Protein Production

Noguchi, Chiemi; Araki, Yoshio; Miki, Daisuke et al. · 2012 · PLoS ONE · DOI

Full title: Fusion of the Dhfr/Mtx and IR/MAR Gene Amplification Methods Produces a Rapid and Efficient Method for Stable Recombinant Protein Production

Authors: Noguchi, Chiemi; Araki, Yoshio; Miki, Daisuke; Shimizu, Noriaki

Year: 2012

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0052990

Paper Multiparameter RNA and Codon Optimization: A Standardized Tool to Assess and Enhance Autologous Mammalian Gene Expression

Fath, Stephan; Bauer, Asli; Liss, Michael A. et al. · 2011 · PLoS ONE · DOI

Full title: Multiparameter RNA and Codon Optimization: A Standardized Tool to Assess and Enhance Autologous Mammalian Gene Expression

Authors: Fath, Stephan; Bauer, Asli; Liss, Michael A.; Spriestersbach, Anne; Maertens, Barbara; Hahn, Peter F.; Ludwig, Christine; Schäfer, Frank; Graf, Marcus; Wagner, Ralf

Year: 2011

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0017596

Paper Biochemical Characterization of Human Anti-Hepatitis B Monoclonal Antibody Produced in the Microalgae Phaeodactylum tricornutum

Vanier, Gaëtan; Hempel, Franziska; Chan, Philippe et al. · 2015 · PLoS ONE · DOI

Full title: Biochemical Characterization of Human Anti-Hepatitis B Monoclonal Antibody Produced in the Microalgae Phaeodactylum tricornutum

Authors: Vanier, Gaëtan; Hempel, Franziska; Chan, Philippe; Rodamer, Michael; Vaudry, David; Maier, Uwe G.; Lerouge, Patrice; Bardor, Muriel

Year: 2015

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0139282

Paper Generation of Biologically Active Multi-Sialylated Recombinant Human EPOFc in Plants

Castilho, Alexandra; Neumann, Laura; Gattinger, Pia et al. · 2013 · PLoS ONE · DOI

Full title: Generation of Biologically Active Multi-Sialylated Recombinant Human EPOFc in Plants

Authors: Castilho, Alexandra; Neumann, Laura; Gattinger, Pia; Strasser, Richard; Vorauer‐Uhl, Karola; Sterovsky, Thomas; Altmann, Friedrich; Steinkellner, Herta

Year: 2013

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0054836

Paper Comparison of Internal Ribosome Entry Site (IRES) and Furin-2A (F2A) for Monoclonal Antibody Expression Level and Quality in CHO Cells

Ho, Steven C. L.; Bardor, Muriel; Li, Bin et al. · 2013 · PLoS ONE · DOI

Full title: Comparison of Internal Ribosome Entry Site (IRES) and Furin-2A (F2A) for Monoclonal Antibody Expression Level and Quality in CHO Cells

Authors: Ho, Steven C. L.; Bardor, Muriel; Li, Bin; Lee, Jia Juan; Song, Zhiwei; Tong, Yen Wah; Goh, Lin‐Tang; Yang, Yuansheng

Year: 2013

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0063247

Paper Transgenic Production of an Anti HIV Antibody in the Barley Endosperm

Hensel, Göetz; Floß, Doreen M.; Arcalís, Elsa et al. · 2015 · PLoS ONE · DOI

Full title: Transgenic Production of an Anti HIV Antibody in the Barley Endosperm

Authors: Hensel, Göetz; Floß, Doreen M.; Arcalís, Elsa; Sack, M.; Melnik, Stanislav; Altmann, Friedrich; Rutten, Twan; Kumlehn, Jochen; Stöger, Eva; Conrad, Udo

Year: 2015

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0140476

Paper Optimization of Heavy Chain and Light Chain Signal Peptides for High Level Expression of Therapeutic Antibodies in CHO Cells

Haryadi, Ryan; Ho, Steven C. L.; Kok, Yee Jiun et al. · 2015 · PLoS ONE · DOI

Full title: Optimization of Heavy Chain and Light Chain Signal Peptides for High Level Expression of Therapeutic Antibodies in CHO Cells

Authors: Haryadi, Ryan; Ho, Steven C. L.; Kok, Yee Jiun; Pu, Helen X.; Zheng, Lu; Pereira, Natasha Ann; Li, Bin; Bi, Xuezhi; Goh, Lin-Tang; Yang, Yuansheng; Song, Zhiwei

Year: 2015

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0116878

Paper Analyzing Clonal Variation of Monoclonal Antibody-Producing CHO Cell Lines Using an In Silico Metabolomic Platform

Ghorbaniaghdam, Atefeh; Chen, Jingkui; Henry, Olivier et al. · 2014 · PLoS ONE · DOI

Full title: Analyzing Clonal Variation of Monoclonal Antibody-Producing CHO Cell Lines Using an In Silico Metabolomic Platform

Authors: Ghorbaniaghdam, Atefeh; Chen, Jingkui; Henry, Olivier; Jolicœur, Mario

Year: 2014

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0090832

Paper The Development of a Recombinant scFv Monoclonal Antibody Targeting Canine CD20 for Use in Comparative Medicine

Jain, Saurabh; Aresu, Luca; Comazzi, S. et al. · 2016 · PLoS ONE · DOI

Full title: The Development of a Recombinant scFv Monoclonal Antibody Targeting Canine CD20 for Use in Comparative Medicine

Authors: Jain, Saurabh; Aresu, Luca; Comazzi, S.; Shi, Jianguo; Worrall, Erin G.; Clayton, John; Humphries, W. R.; Hemmington, Sandra; Davis, Paul J.; Murray, Euan; Limeneh, Asmare A.; Ball, Kathryn L.; Růčková, Eva; Müller, Petr; Vojtěšek, Bořivoj; Fåhræus, Robin; Argyle, David J.; Hupp, Ted R.

Year: 2016

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0148366

Paper Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells

Torres, Mauro; Zúñiga, Roberto Ariel Abeldaño; Gutiérrez-González, Matías et al. · 2018 · PLoS ONE · DOI

Full title: Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells

Authors: Torres, Mauro; Zúñiga, Roberto Ariel Abeldaño; Gutiérrez-González, Matías; Vergara, Mauricio; Collazo, Norberto; Reyes, Juan G.; Berríos, Julio; Aguillón, Juan Carlos; Molina, Marı́a Carmen; Altamirano, Claudia

Year: 2018

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0194510

Paper Evaluating the efficiency of CHEF and CMV promoter with IRES and Furin/2A linker sequences for monoclonal antibody expression in CHO cells

Ebadat, Saeedeh; Ahmadi, Samira; Ahmadi, Maryam et al. · 2017 · PLoS ONE · DOI

Full title: Evaluating the efficiency of CHEF and CMV promoter with IRES and Furin/2A linker sequences for monoclonal antibody expression in CHO cells

Authors: Ebadat, Saeedeh; Ahmadi, Samira; Ahmadi, Maryam; Nematpour, Fatemeh Saeid; Barkhordari, Farzaneh; Mahdian, Reza; Davami, Fatemeh; Mahboudi, Fereidoun

Year: 2017

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0185967

Paper Comparison of secretory signal peptides for heterologous protein expression in microalgae: Expanding the secretion portfolio for Chlamydomonas reinhardtii

Molino, João Vitor Dutra; Carvalho, João Carlos Monteiro de; Mayfield, Stephen P. · 2018 · PLoS ONE · DOI

Full title: Comparison of secretory signal peptides for heterologous protein expression in microalgae: Expanding the secretion portfolio for Chlamydomonas reinhardtii

Authors: Molino, João Vitor Dutra; Carvalho, João Carlos Monteiro de; Mayfield, Stephen P.

Year: 2018

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0192433

Paper Metabolic engineering of CHO cells for the development of a robust protein production platform

Gupta, Sanjeev Kumar; Srivastava, S. K.; Sharma, Ankit et al. · 2017 · PLoS ONE · DOI

Full title: Metabolic engineering of CHO cells for the development of a robust protein production platform

Authors: Gupta, Sanjeev Kumar; Srivastava, S. K.; Sharma, Ankit; Nalage, Vaibhav H. H.; Salvi, Darshita; Kushwaha, Hiralal; Chitnis, Nikhil B.; Shukla, Pratyoosh

Year: 2017

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0181455

Paper REAL-Select: Full-Length Antibody Display and Library Screening by Surface Capture on Yeast Cells

Rhiel, Laura; Krah, Simon; Günther, Ralf et al. · 2014 · PLoS ONE · DOI

Full title: REAL-Select: Full-Length Antibody Display and Library Screening by Surface Capture on Yeast Cells

Authors: Rhiel, Laura; Krah, Simon; Günther, Ralf; Becker, Stefan; Kolmar, Harald; Hock, Björn

Year: 2014

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0114887

Paper Monoclonal antibodies expression improvement in CHO cells by PiggyBac transposition regarding vectors ratios and design

Ahmadi, Samira; Davami, Fatemeh; Davoudi, Noushin et al. · 2017 · PLoS ONE · DOI

Full title: Monoclonal antibodies expression improvement in CHO cells by PiggyBac transposition regarding vectors ratios and design

Authors: Ahmadi, Samira; Davami, Fatemeh; Davoudi, Noushin; Nematpour, Fatemeh Saeid; Ahmadi, Maryam; Ebadat, Saeedeh; Azadmanesh, Kayhan; Barkhordari, Farzaneh; Mahboudi, Fereidoun

Year: 2017

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0179902

Paper Chromatin Function Modifying Elements in an Industrial Antibody Production Platform - Comparison of UCOE, MAR, STAR and cHS4 Elements

Saunders, Fay Louise; Sweeney, Berni; Antoniou, Michael et al. · 2015 · PLoS ONE · DOI

Full title: Chromatin Function Modifying Elements in an Industrial Antibody Production Platform - Comparison of UCOE, MAR, STAR and cHS4 Elements

Authors: Saunders, Fay Louise; Sweeney, Berni; Antoniou, Michael; Stephens, Paul E.; Cain, Katharine

Year: 2015

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0120096

Paper Monoclonal antibodies for the prevention of rabies: theory and clinical practice

Nagarajan, Thirumeni; Marissen, Wilfred E.; Rupprecht, Charles E. · 2014 · Antibody Technology Journal · DOI

Full title: Monoclonal antibodies for the prevention of rabies: theory and clinical practice

Authors: Nagarajan, Thirumeni; Marissen, Wilfred E.; Rupprecht, Charles E.

Year: 2014

Venue: Antibody Technology Journal

DOI: https://doi.org/10.2147/anti.s33533

Paper A system for site-specific integration of transgenes in mammalian cells

Chi, Xiuling; Zheng, Qi; Jiang, Ruhong et al. · 2019 · PLoS ONE · DOI

Full title: A system for site-specific integration of transgenes in mammalian cells

Authors: Chi, Xiuling; Zheng, Qi; Jiang, Ruhong; Chen-Tsai, Ruby Yanru; Kong, Ling-Jie

Year: 2019

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0219842

Paper Advances in improving mammalian cells metabolism for recombinant protein production

Altamirano, Claudia; Berríos, Julio; Vergara, Mauricio et al. · 2013 · Electronic Journal of Biotechnology · DOI

Full title: Advances in improving mammalian cells metabolism for recombinant protein production

Authors: Altamirano, Claudia; Berríos, Julio; Vergara, Mauricio; Becerra, Silvana

Year: 2013

Venue: Electronic Journal of Biotechnology

DOI: https://doi.org/10.2225/vol16-issue3-fulltext-2

Paper Factors Affecting the Expression of Recombinant Protein and Improvement Strategies in Chinese Hamster Ovary Cells

Li, Zhengmei; Fan, Zhenlin; Wang, Xiao-Yin et al. · 2022 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Factors Affecting the Expression of Recombinant Protein and Improvement Strategies in Chinese Hamster Ovary Cells

Authors: Li, Zhengmei; Fan, Zhenlin; Wang, Xiao-Yin; Wang, Tianyun

Year: 2022

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2022.880155

Paper Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry

Sumit Kumar Singh; Kelvin H. Lee · 2022 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry

Authors: Sumit Kumar Singh; Kelvin H. Lee

Year: 2022

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2021.805788

Paper Screening Strategies for High-Yield Chinese Hamster Ovary Cell Clones

Yang, Wenwen; Zhang, Junhe; Xiao, Yunxi et al. · 2022 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Screening Strategies for High-Yield Chinese Hamster Ovary Cell Clones

Authors: Yang, Wenwen; Zhang, Junhe; Xiao, Yunxi; Li, Wenqing; Wang, Tianyun

Year: 2022

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2022.858478

Paper Crystallizable Fragment Glycoengineering for Therapeutic Antibodies Development

Li, Wei; Zhu, Zhongyu; Chen, Weizao et al. · 2017 · Frontiers in Immunology · DOI

Full title: Crystallizable Fragment Glycoengineering for Therapeutic Antibodies Development

Authors: Li, Wei; Zhu, Zhongyu; Chen, Weizao; Feng, Yang; Dimitrov, Dimiter S.

Year: 2017

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2017.01554

Paper Engineering protein glycosylation in CHO cells to be highly similar to murine host cells

Gupta, Shivani; Shah, Bhavana; Fung, Coral Shek et al. · 2023 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Engineering protein glycosylation in CHO cells to be highly similar to murine host cells

Authors: Gupta, Shivani; Shah, Bhavana; Fung, Coral Shek; Chan, Pik K.; Wakefield, Devin L.; Kuhns, Scott; Goudar, Chetan T.; Piret, James M.

Year: 2023

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2023.1113994

Paper Strategies and Considerations for Improving Recombinant Antibody Production and Quality in Chinese Hamster Ovary Cells

Zhang, Junhe; Shan, Linlin; Liang, Fan et al. · 2022 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Strategies and Considerations for Improving Recombinant Antibody Production and Quality in Chinese Hamster Ovary Cells

Authors: Zhang, Junhe; Shan, Linlin; Liang, Fan; Du, Chenyang; Li, Jinɡjinɡ

Year: 2022

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2022.856049

Paper Role of Fc Core Fucosylation in the Effector Function of IgG1 Antibodies

Golay, Josée; Andrea, Alain E.; Cattaneo, Irene · 2022 · Frontiers in Immunology · DOI

Full title: Role of Fc Core Fucosylation in the Effector Function of IgG1 Antibodies

Authors: Golay, Josée; Andrea, Alain E.; Cattaneo, Irene

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.929895

Paper Risk-Based Control Strategies of Recombinant Monoclonal Antibody Charge Variants

Beck, Alain; Nowak, Christine; Meshulam, Deborah et al. · 2022 · Antibodies · DOI

Full title: Risk-Based Control Strategies of Recombinant Monoclonal Antibody Charge Variants

Authors: Beck, Alain; Nowak, Christine; Meshulam, Deborah; Reynolds, Kristina; Chen, David; Pacardo, Dennis B.; Nicholls, Samantha B.; Carven, Gregory J.; Gu, Zhenyu; Fang, Jing; Wang, Dongdong; Katiyar, Amit; Tao, Xiang; Liu, Hongcheng

Year: 2022

Venue: Antibodies

DOI: https://doi.org/10.3390/antib11040073

Paper Protein N-glycosylation in eukaryotic microalgae and its impact on the production of nuclear expressed biopharmaceuticals

Mathieu‐Rivet, Elodie; Kiefer‐Meyer, Marie‐Christine; Vanier, Gaëtan et al. · 2014 · Frontiers in Plant Science · DOI

Full title: Protein N-glycosylation in eukaryotic microalgae and its impact on the production of nuclear expressed biopharmaceuticals

Authors: Mathieu‐Rivet, Elodie; Kiefer‐Meyer, Marie‐Christine; Vanier, Gaëtan; Ovide, ClÃ©ment; Burel, Carole; Lerouge, Patrice; Bardor, Muriel

Year: 2014

Venue: Frontiers in Plant Science

DOI: https://doi.org/10.3389/fpls.2014.00359

Paper Sophisticated Cloning, Fermentation, and Purification Technologies for an Enhanced Therapeutic Protein Production: A Review

Gupta, Sanjeev Kumar; Shukla, Pratyoosh · 2017 · Frontiers in Pharmacology · DOI

Full title: Sophisticated Cloning, Fermentation, and Purification Technologies for an Enhanced Therapeutic Protein Production: A Review

Authors: Gupta, Sanjeev Kumar; Shukla, Pratyoosh

Year: 2017

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2017.00419

Paper Development of a Novel Anti-EpCAM Monoclonal Antibody for Various Applications

Guanjie Li; Hiroyuki Suzuki; Teizo Asano et al. · 2022 · Antibodies · DOI

Full title: Development of a Novel Anti-EpCAM Monoclonal Antibody for Various Applications

Authors: Guanjie Li; Hiroyuki Suzuki; Teizo Asano; Tomohiro Tanaka; Hiroyoshi Suzuki; M. Kaneko; Y. Kato

Year: 2022

Venue: Antibodies

DOI: https://doi.org/10.3390/antib11020041

Paper Putting the Spotlight Back on Plant Suspension Cultures

Santos, Rita B.; Abranches, Rita; Fischer, Rainer et al. · 2016 · Frontiers in Plant Science · DOI

Full title: Putting the Spotlight Back on Plant Suspension Cultures

Authors: Santos, Rita B.; Abranches, Rita; Fischer, Rainer; Sack, M.; Holland, Tanja

Year: 2016

Venue: Frontiers in Plant Science

DOI: https://doi.org/10.3389/fpls.2016.00297

Paper NanoLuc Luciferase – A Multifunctional Tool for High Throughput Antibody Screening

Boute, Nicolas; Lowe, Peter; Berger, Sven et al. · 2016 · Frontiers in Pharmacology · DOI

Full title: NanoLuc Luciferase – A Multifunctional Tool for High Throughput Antibody Screening

Authors: Boute, Nicolas; Lowe, Peter; Berger, Sven; Malissard, Martine; Robert, Alain; Tesar, Michael

Year: 2016

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2016.00027

Paper Improved Titer in Late-Stage Mammalian Cell Culture Manufacturing by Re-Cloning.

He, Qin; Rehmann, Matthew S; Tian, Jun et al. · 2022 · Bioengineering (Basel, Switzerland) · DOI

Full title: Improved Titer in Late-Stage Mammalian Cell Culture Manufacturing by Re-Cloning.

Authors: He, Qin; Rehmann, Matthew S; Tian, Jun; Xu, Jianlin; Sabino, Luzmary; Vandermark, Erik; Basson, Ziev; Po, Iris; Bierilo, Kathleen; Tremml, Gabi; Rizzi, Giovanni; Langsdorf, Erik F; Qian, Nan-Xin; Borys, Michael C; Khetan, Anurag; Li, Zheng-Jian

Year: 2022

Venue: Bioengineering (Basel, Switzerland)

DOI: https://doi.org/10.3390/bioengineering9040173

Paper Current Advancements in Addressing Key Challenges of Therapeutic Antibody Design, Manufacture, and Formulation

Sifniotis, Vicki; Cruz, Esteban; Eroglu, Barbaros et al. · 2019 · Antibodies · DOI

Full title: Current Advancements in Addressing Key Challenges of Therapeutic Antibody Design, Manufacture, and Formulation

Authors: Sifniotis, Vicki; Cruz, Esteban; Eroglu, Barbaros; Kayser, Veysel

Year: 2019

Venue: Antibodies

DOI: https://doi.org/10.3390/antib8020036

Paper Affecting HEK293 Cell Growth and Production Performance by Modifying the Expression of Specific Genes

Abaandou, Laura; Quan, David N.; Shiloach, Joseph · 2021 · Cells · DOI

Full title: Affecting HEK293 Cell Growth and Production Performance by Modifying the Expression of Specific Genes

Authors: Abaandou, Laura; Quan, David N.; Shiloach, Joseph

Year: 2021

Venue: Cells

DOI: https://doi.org/10.3390/cells10071667

Paper Industrial Production of Proteins with Pichia pastoris—Komagataella phaffii

Barone, Giovanni Davide; Emmerstorfer‐Augustin, Anita; Biundo, Antonino et al. · 2023 · Biomolecules · DOI

Full title: Industrial Production of Proteins with Pichia pastoris—Komagataella phaffii

Authors: Barone, Giovanni Davide; Emmerstorfer‐Augustin, Anita; Biundo, Antonino; Pisano, Isabella; Coccetti, Paola; Mapelli, Valeria; Camattari, Andrea

Year: 2023

Venue: Biomolecules

DOI: https://doi.org/10.3390/biom13030441

Paper Function and 3D Structure of the N-Glycans on Glycoproteins

Nagae, Masamichi; Yamaguchi, Yoshiki · 2012 · International Journal of Molecular Sciences · DOI

Full title: Function and 3D Structure of the N-Glycans on Glycoproteins

Authors: Nagae, Masamichi; Yamaguchi, Yoshiki

Year: 2012

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms13078398

Paper Trends in Upstream and Downstream Process Development for Antibody Manufacturing

Gronemeyer, Petra; Ditz, Reinhard; Strube, Jochen · 2014 · Bioengineering · DOI

Full title: Trends in Upstream and Downstream Process Development for Antibody Manufacturing

Authors: Gronemeyer, Petra; Ditz, Reinhard; Strube, Jochen

Year: 2014

Venue: Bioengineering

DOI: https://doi.org/10.3390/bioengineering1040188

Paper A Bench-Top Approach for Isolation of Single Antibody Producing Chinese Hamster Ovary (CHO) Cells Using a Microwell-Based Microfluidic Device.

Fuadiyah, Salma; Chotchindakun, Kittipat; Phatthanakun, Rungrueang et al. · 2022 · Micromachines · DOI

Full title: A Bench-Top Approach for Isolation of Single Antibody Producing Chinese Hamster Ovary (CHO) Cells Using a Microwell-Based Microfluidic Device.

Authors: Fuadiyah, Salma; Chotchindakun, Kittipat; Phatthanakun, Rungrueang; Kuntanawat, Panwong; Yamabhai, Montarop

Year: 2022

Venue: Micromachines

DOI: https://doi.org/10.3390/mi13111939

Paper A Simple Method to Reduce both Lactic Acid and Ammonium Production in Industrial Animal Cell Culture

Freund, N; Croughan, Matthew S. · 2018 · International Journal of Molecular Sciences · DOI

Full title: A Simple Method to Reduce both Lactic Acid and Ammonium Production in Industrial Animal Cell Culture

Authors: Freund, N; Croughan, Matthew S.

Year: 2018

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms19020385

Paper Advances in Mammalian Cell Line Development Technologies for Recombinant Protein Production

Lai, Tingfeng; Yang, Yuansheng; Ng, Say Kong · 2013 · Pharmaceuticals · DOI

Full title: Advances in Mammalian Cell Line Development Technologies for Recombinant Protein Production

Authors: Lai, Tingfeng; Yang, Yuansheng; Ng, Say Kong

Year: 2013

Venue: Pharmaceuticals

DOI: https://doi.org/10.3390/ph6050579

Paper CRISPR Technologies in Chinese Hamster Ovary Cell Line Engineering

Glinšek, Katja; Bozovičar, Krištof; Bratkovič, Tomaž · 2023 · International Journal of Molecular Sciences · DOI

Full title: CRISPR Technologies in Chinese Hamster Ovary Cell Line Engineering

Authors: Glinšek, Katja; Bozovičar, Krištof; Bratkovič, Tomaž

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms24098144

Paper Photopolymer Flexographic Printing Plate Mold for PDMS Microfluidic Manufacture

Ana Belén Peñaherrera‐Pazmiño; Gustavo Rosero; Maximiliano S. Perez et al. · 2025 · Polymers · DOI

Full title: Photopolymer Flexographic Printing Plate Mold for PDMS Microfluidic Manufacture

Authors: Ana Belén Peñaherrera‐Pazmiño; Gustavo Rosero; Maximiliano S. Perez; B. Lerner

Year: 2025

Venue: Polymers

DOI: https://doi.org/10.3390/polym17131723

Paper Identification of Cystatin SN as a novel tumor marker for colorectal cancer.

K. Yoneda; Hiroshi Iida; Hiroki Endo et al. · 2009 · International Journal of Oncology · DOI

Full title: Identification of Cystatin SN as a novel tumor marker for colorectal cancer.

Authors: K. Yoneda; Hiroshi Iida; Hiroki Endo; K. Hosono; Tomoyuki Akiyama; Hirokazu Takahashi; M. Inamori; Y. Abe; M. Yoneda; K. Fujita; S. Kato; Y. Nozaki; Y. Ichikawa; H. Uozaki; M. Fukayama; T. Shimamura; T. Kodama; H. Aburatani; Chihiro Miyazawa; Keisuke Ishii; N. Hosomi; M. Sagara; Masazumi Takahashi; H. Ike; H. Saito; Akihiko Kusakabe; A. Nakajima

Year: 2009

Venue: International Journal of Oncology

DOI: https://doi.org/10.3892/ijo_00000310

Paper Monoclonal antibodies to human interferon‐gamma: production, affinity purification and radioimmunoassay.

D. Novick; Zelig Eshhar; D. Fischer et al. · 1983 · EMBO Journal · DOI

Full title: Monoclonal antibodies to human interferon‐gamma: production, affinity purification and radioimmunoassay.

Authors: D. Novick; Zelig Eshhar; D. Fischer; J. Friedlander; Menachem Rubinstein

Year: 1983

Venue: EMBO Journal

DOI: https://doi.org/10.1002/j.1460-2075.1983.tb01618.x

Paper Amino acids in the cultivation of mammalian cells

Salazar, Andrew; Keusgen, Michael; Hagen, Jörg von · 2016 · Amino Acids · DOI

Full title: Amino acids in the cultivation of mammalian cells

Authors: Salazar, Andrew; Keusgen, Michael; Hagen, Jörg von

Year: 2016

Venue: Amino Acids

DOI: https://doi.org/10.1007/s00726-016-2181-8

Paper Effects of process intensification on homogeneity of an IgG1:κ monoclonal antibody during perfusion culture

Liang, George H.; Madhavarao, Chikkathur N.; Morris, Caitlin et al. · 2024 · Applied Microbiology and Biotechnology · DOI

Full title: Effects of process intensification on homogeneity of an IgG1:κ monoclonal antibody during perfusion culture

Authors: Liang, George H.; Madhavarao, Chikkathur N.; Morris, Caitlin; O'Connor, T; Ashraf, Muhammad; Yoon, Seongkyu

Year: 2024

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-024-13110-9

Paper Transposon vector-mediated stable gene transfer for the accelerated establishment of recombinant mammalian cell pools allowing for high-yield production of biologics

Natalie Tschorn; K. Berg; J. Stitz · 2020 · Biotechnology Letters · DOI

Full title: Transposon vector-mediated stable gene transfer for the accelerated establishment of recombinant mammalian cell pools allowing for high-yield production of biologics

Authors: Natalie Tschorn; K. Berg; J. Stitz

Year: 2020

Venue: Biotechnology Letters

DOI: https://doi.org/10.1007/s10529-020-02889-y

Paper The role of Raman spectroscopy in biopharmaceuticals from development to manufacturing

Esmonde‐White, Karen A.; Cuellar, Maryann; Lewis, Ian R. · 2021 · Analytical and Bioanalytical Chemistry · DOI

Full title: The role of Raman spectroscopy in biopharmaceuticals from development to manufacturing

Authors: Esmonde‐White, Karen A.; Cuellar, Maryann; Lewis, Ian R.

Year: 2021

Venue: Analytical and Bioanalytical Chemistry

DOI: https://doi.org/10.1007/s00216-021-03727-4

Paper Recombinant therapeutic proteins degradation and overcoming strategies in CHO cells

Geng, Shao‐Lei; Zhao, Xiaojie; Zhang, Xi et al. · 2024 · Applied Microbiology and Biotechnology · DOI

Full title: Recombinant therapeutic proteins degradation and overcoming strategies in CHO cells

Authors: Geng, Shao‐Lei; Zhao, Xiaojie; Zhang, Xi; Zhang, Jihong; Mi, Chunliu; Wang, Tianyun

Year: 2024

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-024-13008-6

Paper Albumin and mammalian cell culture: implications for biotechnology applications

Francis, Geoffrey L. · 2010 · Cytotechnology · DOI

Full title: Albumin and mammalian cell culture: implications for biotechnology applications

Authors: Francis, Geoffrey L.

Year: 2010

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-010-9263-3

Paper Developing the Totality of Evidence for Biosimilars: Regulatory Considerations and Building Confidence for the Healthcare Community

Márkus, Richárd; Liu, Jennifer; Ramchandani, Monica et al. · 2017 · BioDrugs · DOI

Full title: Developing the Totality of Evidence for Biosimilars: Regulatory Considerations and Building Confidence for the Healthcare Community

Authors: Márkus, Richárd; Liu, Jennifer; Ramchandani, Monica; Landa, Diana; Born, Teresa L.; Kaur, Primal

Year: 2017

Venue: BioDrugs

DOI: https://doi.org/10.1007/s40259-017-0218-5

Paper Single-Batch Production of Recombinant Human Polyclonal Antibodies

Nielsen, Lars S.; Baer, Alexandra; Müller, Christian et al. · 2010 · Molecular Biotechnology · DOI

Full title: Single-Batch Production of Recombinant Human Polyclonal Antibodies

Authors: Nielsen, Lars S.; Baer, Alexandra; Müller, Christian; Gregersen, Kristian; Mønster, Nina T.; Rasmussen, Søren K.; Weilguny, Dietmar; Tolstrup, Anne B.

Year: 2010

Venue: Molecular Biotechnology

DOI: https://doi.org/10.1007/s12033-010-9270-9

Paper Physicochemical and Functional Comparability Between the Proposed Biosimilar Rituximab GP2013 and Originator Rituximab

Visser, Jan Marinus; Feuerstein, Isabel; Stangler, Thomas et al. · 2013 · BioDrugs · DOI

Full title: Physicochemical and Functional Comparability Between the Proposed Biosimilar Rituximab GP2013 and Originator Rituximab

Authors: Visser, Jan Marinus; Feuerstein, Isabel; Stangler, Thomas; Schmiederer, Timo; Fritsch, Cornelius; Schiestl, Martin

Year: 2013

Venue: BioDrugs

DOI: https://doi.org/10.1007/s40259-013-0036-3

Paper The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

Xu, Xun; Nagarajan, Harish; Lewis, Nathan E. et al. · 2011 · Nature Biotechnology · DOI

Full title: The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

Authors: Xu, Xun; Nagarajan, Harish; Lewis, Nathan E.; Pan, Shengkai; Cai, Zhiming; Liu, Xin; Chen, Wenbin; Xie, Min; Wang, Wenliang; Hammond, Stephanie; Andersen, Mikael Rørdam; Neff, Norma; Passarelli, Benedetto; Koh, Winston; Fan, H. Christina; Wang, Jianbin; Gui, Yaoting; Lee, Kelvin H.; Betenbaugh, Michael J.; Quake, Stephen R.; Famili, Iman; Palsson, Bernhard Ø.; Wang, Jun

Year: 2011

Venue: Nature Biotechnology

DOI: https://doi.org/10.1038/nbt.1932

Paper A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency

Chodorge, Matthieu; Züger, Sara; Stirnimann, Christian U. et al. · 2012 · Cell Death and Differentiation · DOI

Full title: A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency

Authors: Chodorge, Matthieu; Züger, Sara; Stirnimann, Christian U.; Briand, Christophe; Jermutus, Lutz; Grütter, Markus G.; Minter, Ralph

Year: 2012

Venue: Cell Death and Differentiation

DOI: https://doi.org/10.1038/cdd.2011.208

Paper MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP

Yan, Yahui; Rato, Cláudia; Rohland, Lukas et al. · 2019 · Nature Communications · DOI

Full title: MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP

Authors: Yan, Yahui; Rato, Cláudia; Rohland, Lukas; Preißler, Steffen; Ron, David

Year: 2019

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-019-08450-4

Paper The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells

Tian, Weihua; Ye, Zilu; Wang, Shengjun et al. · 2019 · Nature Communications · DOI

Full title: The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells

Authors: Tian, Weihua; Ye, Zilu; Wang, Shengjun; Schulz, Morten Alder; Coillie, Julie Van; Sun, Lingbo; Chen, Yen‐Hsi; Narimatsu, Yoshiki; Hansen, Lars Hestbjerg; Kristensen, Claus; Mandel, Ulla; Bennett, Eric; Jabbarzadeh‐Tabrizi, Siamak; Schiffmann, Raphael; Shen, Jin‐Song; Vakhrushev, Sergey Y.; Clausen, Henrik; Yang, Zhang

Year: 2019

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-019-09809-3

Paper S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

Liang, Joshua G.; Su, Danmei; Song, Tian‐Zhang et al. · 2021 · Nature Communications · DOI

Full title: S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

Authors: Liang, Joshua G.; Su, Danmei; Song, Tian‐Zhang; Zeng, Yilan; Huang, Weijin; Wu, Jinhua; Xu, Rong; Luo, Peiwen; Yang, Xiaofang; Zhang, Xiaodong; Luo, Shuangru; Liang, Ying; Li, Xinglin; Huang, Jiaju; Wang, Qiang; Huang, Xueqin; Xu, Qingsong; Luo, Mei; Huang, Anliang; Luo, Dongxia; Zhao, Chenyan; Yang, Fan; Han, Jian-Bao; Zheng, Yong‐Tang; Liang, Peng

Year: 2021

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-021-21634-1

Paper Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG

Fischer, Nicolas; Elson, Greg; Magistrelli, Giovanni et al. · 2015 · Nature Communications · DOI

Full title: Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG

Authors: Fischer, Nicolas; Elson, Greg; Magistrelli, Giovanni; Dheilly, Elie; Fouque, Nicolas; Laurendon, Amélie; Gueneau, Franck; Ravn, Ulla; Depoisier, Jean-François; Moine, Valéry; Raimondi, Sylvain; Malinge, Pauline; Grazia, Laura Di; Rousseau, François; Poitevin, Yves; Calloud, Sébastien; Cayatte, Pierre-Alexis; Alcoz, Mathias; Pontini, Guillemette; Fagète, Séverine; Broyer, Lucile; Corbier, Marie; Schrag, Delphine; Didelot, Gérard; Bosson, Nicolas; Costes, Nicolas; Cons, Laura; Buatois, Vanessa; Johnson, Zoë; Ferlin, Walter; Masternak, Krzysztof; Kosco‐Vilbois, Marie

Year: 2015

Venue: Nature Communications

DOI: https://doi.org/10.1038/ncomms7113

Paper Multiplex secretome engineering enhances recombinant protein production and purity

Kol, Stefan; Ley, Daniel; Wulff, Tune et al. · 2020 · Nature Communications · DOI

Full title: Multiplex secretome engineering enhances recombinant protein production and purity

Authors: Kol, Stefan; Ley, Daniel; Wulff, Tune; Decker, Marianne; Arnsdorf, Johnny; Schoffelen, Sanne; Hansen, Anders Holmgaard; Jensen, Tanja Lyholm; Gutierrez, Jahir M.; Chiang, Austin W.T.; Masson, Helen O.; Palsson, Bernhard Ø.; Voldborg, Björn G.; Pedersen, Lasse Ebdrup; Kildegaard, Helene Faustrup; Lee, Gyun Min; Lewis, Nathan E.

Year: 2020

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-020-15866-w

Paper Developing therapeutic monoclonal antibodies at pandemic pace

Kelley, Brian D. · 2020 · Nature Biotechnology · DOI

Full title: Developing therapeutic monoclonal antibodies at pandemic pace

Authors: Kelley, Brian D.

Year: 2020

Venue: Nature Biotechnology

DOI: https://doi.org/10.1038/s41587-020-0512-5

Paper Single-cell sorting based on secreted products for functionally defined cell therapies

Miwa, Hiromi; Dimatteo, Robert; Rutte, Joseph de et al. · 2022 · Microsystems & Nanoengineering · DOI

Full title: Single-cell sorting based on secreted products for functionally defined cell therapies

Authors: Miwa, Hiromi; Dimatteo, Robert; Rutte, Joseph de; Ghosh, Rajesh; Carlo, Dino Di

Year: 2022

Venue: Microsystems & Nanoengineering

DOI: https://doi.org/10.1038/s41378-022-00422-x

Paper Protein design and variant prediction using autoregressive generative models

Shin, Jung-Eun; Riesselman, Adam J.; Kollasch, Aaron W. et al. · 2021 · Nature Communications · DOI

Full title: Protein design and variant prediction using autoregressive generative models

Authors: Shin, Jung-Eun; Riesselman, Adam J.; Kollasch, Aaron W.; McMahon, Conor; Simon, Elana P.; Sander, Chris; Manglik, Aashish; Kruse, Andrew C.; Marks, Debora S.

Year: 2021

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-021-22732-w

Paper A human expression system based on HEK293 for the stable production of recombinant erythropoietin

Chin, Christine Lin; Goh, Justin B.; Srinivasan, Harini et al. · 2019 · Scientific Reports · DOI

Full title: A human expression system based on HEK293 for the stable production of recombinant erythropoietin

Authors: Chin, Christine Lin; Goh, Justin B.; Srinivasan, Harini; Liu, Kaiwen Ivy; Ali, Gowher; Shanmugam, Raghuvaran; Lim, Hsueh Lee; Choo, Matthew S.; Tang, Wen Qin; Tan, Andy Hee‐Meng; Nguyen‐Khuong, Terry; Tan, Meng How; Ng, Say Kong

Year: 2019

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-019-53391-z

Paper High-yield production of “difficult-to-express” proteins in a continuous exchange cell-free system based on CHO cell lysates

Thoring, Lena; Dondapati, Srujan Kumar; Stech, Marlitt et al. · 2017 · Scientific Reports · DOI

Full title: High-yield production of “difficult-to-express” proteins in a continuous exchange cell-free system based on CHO cell lysates

Authors: Thoring, Lena; Dondapati, Srujan Kumar; Stech, Marlitt; Wüstenhagen, Doreen A.; Kubick, Stefan

Year: 2017

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-017-12188-8

Paper Next generation of anti-PD-L1 Atezolizumab with enhanced anti-tumor efficacy in vivo

Li, Maohua; Zhao, Rongqing; Chen, Jianxin et al. · 2021 · Scientific Reports · DOI

Full title: Next generation of anti-PD-L1 Atezolizumab with enhanced anti-tumor efficacy in vivo

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Year: 2021

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-021-85329-9

Paper Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

Noh, Soo Min; Shin, Seunghyeon; Lee, Gyun Min · 2018 · Scientific Reports · DOI

Full title: Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

Authors: Noh, Soo Min; Shin, Seunghyeon; Lee, Gyun Min

Year: 2018

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-018-23720-9

Paper Selection and characterization of DNA aptamer against glucagon receptor by cell-SELEX

Wang, Guodong; Liu, Jun; Chen, Ke et al. · 2017 · Scientific Reports · DOI

Full title: Selection and characterization of DNA aptamer against glucagon receptor by cell-SELEX

Authors: Wang, Guodong; Liu, Jun; Chen, Ke; Xu, Yiling; Liu, Bo; Liao, Jie; Zhu, Lei; Hu, Xiaoxiao; Li, Jianglin; Pu, Ying; Zhong, Wen; Fu, Ting; Liu, Huixia; Tan, Weihong

Year: 2017

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-017-05840-w

Paper Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system

S. Murakami; R. Matsumoto; T. Kanamori · 2019 · Scientific Reports · DOI

Full title: Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system

Authors: S. Murakami; R. Matsumoto; T. Kanamori

Year: 2019

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-018-36691-8

Paper Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

H. Hansen; Claes Nymand Nilsson; A. Lund et al. · 2015 · Scientific Reports · DOI

Full title: Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Authors: H. Hansen; Claes Nymand Nilsson; A. Lund; S. Kol; L. M. Grav; Magnus Lundqvist; Johan Rockberg; G. Lee; M. Andersen; H. F. Kildegaard

Year: 2015

Venue: Scientific Reports

DOI: https://doi.org/10.1038/srep18016

Paper Identification of a monoclonal antibody that targets PD-1 in a manner requiring PD-1 Asn58 glycosylation

Wang, Mingzhu; Wang, Junchao; Wang, Rongjuan et al. · 2019 · Communications Biology · DOI

Full title: Identification of a monoclonal antibody that targets PD-1 in a manner requiring PD-1 Asn58 glycosylation

Authors: Wang, Mingzhu; Wang, Junchao; Wang, Rongjuan; Jiao, Shasha; Wang, Shuang; Zhang, Jinchao; Zhang, Min

Year: 2019

Venue: Communications Biology

DOI: https://doi.org/10.1038/s42003-019-0642-9

Paper Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR

Panousis, Con; Rayzman, Veronika; Johns, Terrance G. et al. · 2005 · British Journal of Cancer · DOI

Full title: Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR

Authors: Panousis, Con; Rayzman, Veronika; Johns, Terrance G.; Renner, Christoph; Liu, Zhong; Cartwright, Gary A.; Lee, F-T; Wang, D; Gan, Hui; Cao, Di; Kypridis, A; Smyth, Fiona E.; Brechbiel, Martin W.; Burgess, Antony W.; Old, Lloyd J.; Scott, Andrew M.

Year: 2005

Venue: British Journal of Cancer

DOI: https://doi.org/10.1038/sj.bjc.6602470

Paper The ENGases: versatile biocatalysts for the production of homogeneous N-linked glycopeptides and glycoproteins

Fairbanks, Antony J. · 2017 · Chemical Society Reviews · DOI

Full title: The ENGases: versatile biocatalysts for the production of homogeneous N-linked glycopeptides and glycoproteins

Authors: Fairbanks, Antony J.

Year: 2017

Venue: Chemical Society Reviews

DOI: https://doi.org/10.1039/c6cs00897f

Paper CMV promoter mutants with a reduced propensity to productivity loss in CHO cells

Moritz, Benjamin; Becker, Peter B.; Göpfert, Ulrich · 2015 · Scientific Reports · DOI

Full title: CMV promoter mutants with a reduced propensity to productivity loss in CHO cells

Authors: Moritz, Benjamin; Becker, Peter B.; Göpfert, Ulrich

Year: 2015

Venue: Scientific Reports

DOI: https://doi.org/10.1038/srep16952

Paper Impact of Different Promoters on Episomal Vectors Harbouring Characteristic Motifs of Matrix Attachment Regions

Wang, Xiao-Yin; Zhang, Jun‐He; Zhang, Xi et al. · 2016 · Scientific Reports · DOI

Full title: Impact of Different Promoters on Episomal Vectors Harbouring Characteristic Motifs of Matrix Attachment Regions

Authors: Wang, Xiao-Yin; Zhang, Jun‐He; Zhang, Xi; Sun, Qiu‐li; Zhao, Chun-Peng; Wang, Tianyun

Year: 2016

Venue: Scientific Reports

DOI: https://doi.org/10.1038/srep26446

Paper Matrix attachment region combinations increase transgene expression in transfected Chinese hamster ovary cells

Zhao, Chun‐Peng; Guo, Xiao; Chen, Si‐Jia et al. · 2017 · Scientific Reports · DOI

Full title: Matrix attachment region combinations increase transgene expression in transfected Chinese hamster ovary cells

Authors: Zhao, Chun‐Peng; Guo, Xiao; Chen, Si‐Jia; Li, Changzheng; Yang, Yun; Zhang, Junhe; Chen, Shao-nan; Jia, Yan‐Long; Wang, Tianyun

Year: 2017

Venue: Scientific Reports

DOI: https://doi.org/10.1038/srep42805

Paper Analytical Characterization of Monoclonal Antibodies with Novel Fc Receptor-Based Chromatography Technique

A. Chakrabarti; J. Kervinen; E. Müller et al. · 2020 · Monoclonal Antibodies [Working Title] · DOI

Full title: Analytical Characterization of Monoclonal Antibodies with Novel Fc Receptor-Based Chromatography Technique

Authors: A. Chakrabarti; J. Kervinen; E. Müller; Toru Tanaka; Kazuaki Muranaka

Year: 2020

Venue: Monoclonal Antibodies [Working Title]

DOI: https://doi.org/10.5772/intechopen.95356

Paper The impact of cell culture on medicine

Ying Chun Lu; Taohsueh Liao · 2024 · ASEAN Journal of Psychiatry · DOI

Full title: The impact of cell culture on medicine

Authors: Ying Chun Lu; Taohsueh Liao

Year: 2024

Venue: ASEAN Journal of Psychiatry

DOI: https://doi.org/10.54615/2231-7805.20169

Paper Strategies for Glycoengineering Therapeutic Proteins

Dammen‐Brower, Kris; Epler, Paige; Zhu, Stanley et al. · 2022 · Frontiers in Chemistry · DOI

Full title: Strategies for Glycoengineering Therapeutic Proteins

Authors: Dammen‐Brower, Kris; Epler, Paige; Zhu, Stanley; Bernstein, Zachary J.; Stabach, Paul R.; Braddock, Demetrios T.; Spangler, Jamie B.; Yarema, Kevin J.

Year: 2022

Venue: Frontiers in Chemistry

DOI: https://doi.org/10.3389/fchem.2022.863118

Paper Recent Developments in Bioprocessing of Recombinant Proteins: Expression Hosts and Process Development

Tripathi, Nagesh K.; Shrivastava, Ambuj · 2019 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Recent Developments in Bioprocessing of Recombinant Proteins: Expression Hosts and Process Development

Authors: Tripathi, Nagesh K.; Shrivastava, Ambuj

Year: 2019

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2019.00420

Paper Expression of Recombinant Antibodies

Frenzel, André; Hust, Michael; Schirrmann, Thomas · 2013 · Frontiers in Immunology · DOI

Full title: Expression of Recombinant Antibodies

Authors: Frenzel, André; Hust, Michael; Schirrmann, Thomas

Year: 2013

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2013.00217

Paper Improving Immunotherapy Through Glycodesign

Buettner, Matthew J.; Shah, Sagar; Saeui, Christopher T. et al. · 2018 · Frontiers in Immunology · DOI

Full title: Improving Immunotherapy Through Glycodesign

Authors: Buettner, Matthew J.; Shah, Sagar; Saeui, Christopher T.; Ariss, Ryan; Yarema, Kevin J.

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.02485

Thesis Development of a novel bioreactor and systems for suspension cell culture in biopharmaceutical production

Sharma, Rajesh · 2022 · University of Cape Town · DOI

Full title: Development of a novel bioreactor and systems for suspension cell culture in biopharmaceutical production

Authors: Sharma, Rajesh

Year: 2022

Venue: University of Cape Town

DOI: http://hdl.handle.net/11427/36112

Thesis Sobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes

Bulté Ocaña, Dubhe Beatriz · 2021 · Universidad Nacional Autónoma de México (UNAM) · DOI

Full title: Sobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes

Authors: Bulté Ocaña, Dubhe Beatriz

Year: 2021

Venue: Universidad Nacional Autónoma de México (UNAM)

DOI: https://hdl.handle.net/20.500.14330/TES01000806237

Thesis Improving protein yield from mammalian cells by manipulation of stress response pathways

Chalmers, Fiona · 2016 · University of Glasgow · DOI

Full title: Improving protein yield from mammalian cells by manipulation of stress response pathways

Authors: Chalmers, Fiona

Year: 2016

Venue: University of Glasgow

DOI: https://theses.gla.ac.uk/7666/7/2016ChalmersPhD.pdf

Thesis Impact de la modification du métabolisme primaire des cellules CHO sur leur productivité

Toussaint, Cecile · 2017 · Université de Montréal (Papyrus) · DOI

Full title: Impact de la modification du métabolisme primaire des cellules CHO sur leur productivité

Authors: Toussaint, Cecile

Year: 2017

Venue: Université de Montréal (Papyrus)

DOI: http://hdl.handle.net/1866/18549

Thesis Recombinant protein production utilising a metallothionein expression system and a Super-CHO cell line

Huang, Edwin P.C. · 2006 · UNSW Sydney · DOI

Full title: Recombinant protein production utilising a metallothionein expression system and a Super-CHO cell line

Authors: Huang, Edwin P.C.

Year: 2006

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/24940

Thesis Transient production of biopharmaceutical proteins

Wei, Tzu-Hsiang · 2009 · UNSW Sydney · DOI

Full title: Transient production of biopharmaceutical proteins

Authors: Wei, Tzu-Hsiang

Year: 2009

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/43708

Thesis Effects of imperfect mixing in suspended plant and animal cell cultures

Cheung, Caleb Kin Lok · 2006 · UNSW Sydney · DOI

Full title: Effects of imperfect mixing in suspended plant and animal cell cultures

Authors: Cheung, Caleb Kin Lok

Year: 2006

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/25200

Thesis The Biological Impact of High Throughput Continuous Bioprocessing

Sewell, David John · 2020 · University of Cambridge · DOI

Full title: The Biological Impact of High Throughput Continuous Bioprocessing

Authors: Sewell, David John

Year: 2020

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/311711

Thesis Appendix for: "Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch"

Gangadharan, Nishanthi · 2023 · University of Cambridge · DOI

Full title: Appendix for: "Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch"

Authors: Gangadharan, Nishanthi

Year: 2023

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/347248

Thesis A study of apoptosis and cell cycle to augment transfection efficiency in CHO cell lines

Wanandy, Nico Stanislaus · 2007 · UNSW Sydney · DOI

Full title: A study of apoptosis and cell cycle to augment transfection efficiency in CHO cell lines

Authors: Wanandy, Nico Stanislaus

Year: 2007

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/40868

Thesis Construction, expression and characterisation of a human anti-CD48 monoclonal antibody

Wei, Jiewei · 2006 · UNSW Sydney · DOI

Full title: Construction, expression and characterisation of a human anti-CD48 monoclonal antibody

Authors: Wei, Jiewei

Year: 2006

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/27413

Thesis Investigation of the factors affecting serum-free growth of the animal cell line CHO K1

Bridges, Michael · 1995 · UNSW Sydney · DOI

Full title: Investigation of the factors affecting serum-free growth of the animal cell line CHO K1

Authors: Bridges, Michael

Year: 1995

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/57409

Thesis Increasing biomass production in bioreactors applying metabolic analysis and engineering tools

Comas Sanchez, Pere · 2021 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Increasing biomass production in bioreactors applying metabolic analysis and engineering tools

Authors: Comas Sanchez, Pere

Year: 2021

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/671074

Thesis Development of tools for monitoring and controlling cell cultures through the metabolic analysis

Martínez Monge, Iván · 2018 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Development of tools for monitoring and controlling cell cultures through the metabolic analysis

Authors: Martínez Monge, Iván

Year: 2018

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/664350

Thesis Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.

Kumpel, Belinda M; Saldova, Radka; Koeleman, Carolien AM et al. · 2021 · University of Cambridge · DOI

Full title: Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.

Authors: Kumpel, Belinda M; Saldova, Radka; Koeleman, Carolien AM; Abrahams, Jodie L; Ederveen, Agnes Hipgrave; Armour, Kathryn L; Olovnikova, Natalia I; Vidarsson, Gestur; Kapur, Rick; Rudd, Pauline M; Wuhrer, Manfred

Year: 2021

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/316867

Thesis Enhancing the Functionality of a Microscale Bioreactor System as an Industrial Process Development Tool for Mammalian Perfusion Culture

Sewell, David J; Turner, Richard; Field, Ray et al. · 2019 · University of Cambridge · DOI

Full title: Enhancing the Functionality of a Microscale Bioreactor System as an Industrial Process Development Tool for Mammalian Perfusion Culture

Authors: Sewell, David J; Turner, Richard; Field, Ray; Holmes, William; Pradhan, Rahul; Spencer, Christopher; Oliver, Stephen; Slater, Nigel; Dikicioglu, Duygu

Year: 2019

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/289313

Thesis Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.

Traustason, Bergthor; Cheeks, Matthew; Dikicioglu, Duygu · 2020 · University of Cambridge · DOI

Full title: Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.

Authors: Traustason, Bergthor; Cheeks, Matthew; Dikicioglu, Duygu

Year: 2020

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/301284

Thesis Challenges and Opportunities for the Large-Scale Chemoenzymatic Glycoengineering of Therapeutic N-Glycosylated Monoclonal Antibodies

Ivanova, Adelina; Falcioni, Francesco · 2022 · University of Cambridge · DOI

Full title: Challenges and Opportunities for the Large-Scale Chemoenzymatic Glycoengineering of Therapeutic N-Glycosylated Monoclonal Antibodies

Authors: Ivanova, Adelina; Falcioni, Francesco

Year: 2022

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/334145

Thesis Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Murayyan, Abdulmonem · 2013 · University of Guelph · DOI

Full title: Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Authors: Murayyan, Abdulmonem

Year: 2013

Venue: University of Guelph

DOI: http://hdl.handle.net/10214/6604

Thesis The Assessment of MAb Quality and Quantity

Drouillard, Gerald · 2015 · University of Guelph · DOI

Full title: The Assessment of MAb Quality and Quantity

Authors: Drouillard, Gerald

Year: 2015

Venue: University of Guelph

DOI: http://hdl.handle.net/10214/8743

Thesis High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

Zhang, Ye · 2017 · KTH Royal Institute of Technology · DOI

Full title: High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

Authors: Zhang, Ye

Year: 2017

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-207600

Thesis Genomic and transcriptomic approaches for the advancement of CHO cell bioprocessing

Vishwanathan, Nandita · 2014 · University of Minnesota - Digital Conservancy · DOI

Full title: Genomic and transcriptomic approaches for the advancement of CHO cell bioprocessing

Authors: Vishwanathan, Nandita

Year: 2014

Venue: University of Minnesota - Digital Conservancy

DOI: http://hdl.handle.net/11299/165110

Thesis Computational Fluid Dynamics Simulations of Single-Use Bioreactors for the Scale-Up of Cell Culture Processes

Kreitmayer, Diana · 2022 · Heidelberg University · DOI

Full title: Computational Fluid Dynamics Simulations of Single-Use Bioreactors for the Scale-Up of Cell Culture Processes

Authors: Kreitmayer, Diana

Year: 2022

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/32116/1/DissertationDianaKreitmayer.pdf

Thesis Methods for cell line and protein engineering

Lundqvist, Magnus · 2018 · KTH Royal Institute of Technology · DOI

Full title: Methods for cell line and protein engineering

Authors: Lundqvist, Magnus

Year: 2018

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-227195

Thesis Macroscopic models of Chinese hamster ovary cell cultures

Hagrot, Erika · 2019 · KTH Royal Institute of Technology · DOI

Full title: Macroscopic models of Chinese hamster ovary cell cultures

Authors: Hagrot, Erika

Year: 2019

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-262850

Thesis Cell line and protein engineering tools for production and characterization of biologics

Volk, Anna-Luisa · 2017 · KTH Royal Institute of Technology · DOI

Full title: Cell line and protein engineering tools for production and characterization of biologics

Authors: Volk, Anna-Luisa

Year: 2017

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-212931

Thesis Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022 · KTH Royal Institute of Technology · DOI

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

Year: 2022

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis Magnetic bead-based isolation of biological therapeutic modalities

Brechmann, Nils A. · 2022 · KTH Royal Institute of Technology · DOI

Full title: Magnetic bead-based isolation of biological therapeutic modalities

Authors: Brechmann, Nils A.

Year: 2022

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-321336

Thesis A computational framework for predicting CHO cell culture performance in bioreactors

Cárcamo Behrens, Martín. · 2019 · Massachusetts Institute of Technology (MIT) · DOI

Full title: A computational framework for predicting CHO cell culture performance in bioreactors

Authors: Cárcamo Behrens, Martín.

Year: 2019

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/123055

Thesis Recycling and Regeneration of Spent Perfusion Media via Ion Concentration Polarization

Wynne, Eric Michael · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Recycling and Regeneration of Spent Perfusion Media via Ion Concentration Polarization

Authors: Wynne, Eric Michael

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/164151

Thesis Glycosylation site occupancy heterogeneity in Chinese hamster ovary cell culture

Nyberg, Gregg B. (Gregg Bartell), 1970- · 2005 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Glycosylation site occupancy heterogeneity in Chinese hamster ovary cell culture

Authors: Nyberg, Gregg B. (Gregg Bartell), 1970-

Year: 2005

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/28190

Thesis Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays

Rohskopf, Zhumei · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays

Authors: Rohskopf, Zhumei

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/152457

Thesis Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Maloney, Andrew John · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Authors: Maloney, Andrew John

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/158315

Thesis Increasing IFN-[gamma] productivity in CHO cells through CDK inhibition

McClain, David Alan · 2010 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Increasing IFN-[gamma] productivity in CHO cells through CDK inhibition

Authors: McClain, David Alan

Year: 2010

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/60138

Thesis Systems Engineering for Viral Vector Manufacturing

Nguyen, Tam Ngoc Thanh · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Systems Engineering for Viral Vector Manufacturing

Authors: Nguyen, Tam Ngoc Thanh

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/150243

Thesis Active hypothermic growth : a novel means for increasing total recombinant protein production by CHO cells

Fox, Stephen Richard · 2008 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Active hypothermic growth : a novel means for increasing total recombinant protein production by CHO cells

Authors: Fox, Stephen Richard

Year: 2008

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://dspace.mit.edu/handle/1721.1/32333

Thesis Comparison of the growth and monoclonal antibody production of suspended mammalian cells in three perfusion systems

Hufford, Kathy (Kathy E.) · 2008 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Comparison of the growth and monoclonal antibody production of suspended mammalian cells in three perfusion systems

Authors: Hufford, Kathy (Kathy E.)

Year: 2008

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/39921

Thesis Molecular, Genetic, and Process Approaches for Improving Secreted Pharmaceutical Protein Quality in Komagataella phaffii

Yang, Yuchen · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Molecular, Genetic, and Process Approaches for Improving Secreted Pharmaceutical Protein Quality in Komagataella phaffii

Authors: Yang, Yuchen

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/157251

Thesis Enhancing mammalian bioprocessing through engineering Chinese hamster ovary cell metabolism

Hefzi, Hooman · 2018 · University of California, San Diego (UCSD) · DOI

Full title: Enhancing mammalian bioprocessing through engineering Chinese hamster ovary cell metabolism

Authors: Hefzi, Hooman

Year: 2018

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/91h2z79t

Thesis Characterization of the down regulation of antibody production in high cell density perfusion culture

Morrill, Joyce Catherine · 2006 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Characterization of the down regulation of antibody production in high cell density perfusion culture

Authors: Morrill, Joyce Catherine

Year: 2006

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/32602

Thesis Strategies to improve protein production of Chinese hamster ovary cell lines and genome annotation under the guidance of high throughput omics technology

Li, Shangzhong · 2019 · University of California, San Diego (UCSD) · DOI

Full title: Strategies to improve protein production of Chinese hamster ovary cell lines and genome annotation under the guidance of high throughput omics technology

Authors: Li, Shangzhong

Year: 2019

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/1d30f4xc

Thesis Molecular dynamics of monoclonal antibody production in high density perfused bioreactors

Buser, Claudia Waltraut · 2008 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Molecular dynamics of monoclonal antibody production in high density perfused bioreactors

Authors: Buser, Claudia Waltraut

Year: 2008

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/43915

Thesis Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Cosenza, Zachary Anthony · 2022 · University of California, Davis · DOI

Full title: Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Authors: Cosenza, Zachary Anthony

Year: 2022

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/119489fc

Thesis Quantitative Analysis of Proteome Dynamics in Chinese Hamster Ovary cells

Florczak, Beata D · 2019 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Quantitative Analysis of Proteome Dynamics in Chinese Hamster Ovary cells

Authors: Florczak, Beata D

Year: 2019

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/25823/1/B.Florczak_thesis.pdf

Thesis Applications of Protein Engineering in Synthetic Biology and Bioproduction

Minami, Shiaki · 2023 · University of California, Davis · DOI

Full title: Applications of Protein Engineering in Synthetic Biology and Bioproduction

Authors: Minami, Shiaki

Year: 2023

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/8p08541h

Thesis Engineering Oxidative Stress Resistance in CHO Cell Factories

Fairbrass, Danielle L · 2016 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Engineering Oxidative Stress Resistance in CHO Cell Factories

Authors: Fairbrass, Danielle L

Year: 2016

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/16227/1/Master_Copy_DLFairbrassThesis.pdf

Thesis High-Throughput Platform Development for Chinese Hamster Ovary (CHO) Cell Culture Performance Enhancement Using Small Molecules.

Kalsi, Devika · 2018 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: High-Throughput Platform Development for Chinese Hamster Ovary (CHO) Cell Culture Performance Enhancement Using Small Molecules.

Authors: Kalsi, Devika

Year: 2018

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/23127/1/Devika%20Kalsi%20PhD%20Thesis_corrected%20copy.pdf

Thesis Multigene engineering of secretion in mammalian cell factories

Barber, Nicholas · 2019 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Multigene engineering of secretion in mammalian cell factories

Authors: Barber, Nicholas

Year: 2019

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/25495/1/FINALPDF%20NB%20Jun19%20corrections%20Multigene%20engineering%20of%20secretion%20in%20mammalian%20cell%20factories.pdf

Thesis Investigating the rules governing N-linked glycosylation of Biologics

Ayre, Josephine · 2023 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Investigating the rules governing N-linked glycosylation of Biologics

Authors: Ayre, Josephine

Year: 2023

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/34913/1/Ayre_204009713_CorrectedThesisClean2.pdf

Thesis Manipulation of Endoplasmic Reticulum Folding and Assembly Machinery for Improved Production of Complex Biotherapeutics

Swindley, Oscar · 2021 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Manipulation of Endoplasmic Reticulum Folding and Assembly Machinery for Improved Production of Complex Biotherapeutics

Authors: Swindley, Oscar

Year: 2021

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/29353/1/Oscar_Swindley_Thesis_Corrected_FinalAmendment_Aug2021.pdf

Thesis Screening and development of natural compounds as tools to improve IgG production and quality in recombinant CHO cell culture

Toronjo Urquiza, Luis · 2018 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Screening and development of natural compounds as tools to improve IgG production and quality in recombinant CHO cell culture

Authors: Toronjo Urquiza, Luis

Year: 2018

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/25707/1/Screening%20and%20development%20of%20natural%20compounds%20as%20tools%20to%20improve%20IgG%20production%20and%20quality%20in%20recombinant%20CHO%20cell%20culture%20final.pdf

Thesis Characterisation of Cell Lines with Engineered Golgi Organisation

Spencer, Hannah · 2022 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Characterisation of Cell Lines with Engineered Golgi Organisation

Authors: Spencer, Hannah

Year: 2022

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/31162/1/HannahSpencerThesis.pdf

Thesis CHO cell multigene engineering by directed evolution

Jawara, Chillel · 2023 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: CHO cell multigene engineering by directed evolution

Authors: Jawara, Chillel

Year: 2023

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/36961/1/Jawara_Chillel_190186993_PhDThesis_Final.pdf

Thesis Using Emerging Next-Generation Sequencing Technologies to Enhance the Lifecycle of Biopharmaceuticals

shamie, isaac · 2022 · University of California, San Diego (UCSD) · DOI

Full title: Using Emerging Next-Generation Sequencing Technologies to Enhance the Lifecycle of Biopharmaceuticals

Authors: shamie, isaac

Year: 2022

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/55x7t985

Thesis Integrated cell and bioprocess engineering for rapid and intensive continuous production of biopharmaceuticals

Morgan-Evans, William · 2020 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Integrated cell and bioprocess engineering for rapid and intensive continuous production of biopharmaceuticals

Authors: Morgan-Evans, William

Year: 2020

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/29148/1/Integrated%20cell%20and%20bioprocess%20engineering%20for%20rapid%20and%20intensive%20continuous%20production%20of%20biopharmaceuticals%2C%20William%20Morgan-Evans%20%282020%29.pdf

Thesis Developing novel biosensors for monitoring antibody production in Chinese Hamster Ovary (CHO) cells

Willmott, Jessica · 2022 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Developing novel biosensors for monitoring antibody production in Chinese Hamster Ovary (CHO) cells

Authors: Willmott, Jessica

Year: 2022

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/32583/1/Willmott%2C%20Jessica%2C%20170246628%20-%20Complete%20with%20Corrections.pdf

Thesis Use of CHO cell synthetic promoters to control transcription of mAb expression vector genes and screening of ER genes for their effect on mAb production

Kerry, William · 2022 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Use of CHO cell synthetic promoters to control transcription of mAb expression vector genes and screening of ER genes for their effect on mAb production

Authors: Kerry, William

Year: 2022

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/32010/2/William%20Kerry%20Corrected%20PhD%20thesis%20November%202022%20minus%20appendix.pdf

Thesis Adaptation to suspension growth: analysing the surface of suspension growth adapted Chinese hamster ovary cells

Walther, Christa G · 2013 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Adaptation to suspension growth: analysing the surface of suspension growth adapted Chinese hamster ovary cells

Authors: Walther, Christa G

Year: 2013

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/4193/1/final_version_-_all_chapters.pdf

Thesis Development of an integrated platform for the production of recombinant biopharmaceuticals

Segarra, Camille · 2013 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Development of an integrated platform for the production of recombinant biopharmaceuticals

Authors: Segarra, Camille

Year: 2013

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/4147/1/Segarra_Thesis_PostCorrections.pdf

Thesis Characterising Chinese Hamster Ovary Cell Extracellular Vesicle Production in Biopharmaceutical Manufacturing

O'Donnell, Fergal · 2022 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Characterising Chinese Hamster Ovary Cell Extracellular Vesicle Production in Biopharmaceutical Manufacturing

Authors: O'Donnell, Fergal

Year: 2022

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/33062/1/Thesis_Corrections.pdf

Thesis The role of intracellular signalling pathways in CHO cell growth in a synthetic environment

Whitfield, Robert · 2014 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: The role of intracellular signalling pathways in CHO cell growth in a synthetic environment

Authors: Whitfield, Robert

Year: 2014

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/6454/1/Rob%20Whitfield%20Final%20Thesis%20Submission.pdf

Thesis Cell Line and Process Development for Improved Transient Production of a "Difficult-to-Express" Fusion Protein by CHO Cells

Johari, YB · 2015 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Cell Line and Process Development for Improved Transient Production of a "Difficult-to-Express" Fusion Protein by CHO Cells

Authors: Johari, YB

Year: 2015

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/9265/1/PhD%20thesis%20-%20YB%20Johari%20%5BFINAL%5D.pdf

Thesis Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

Zagari, Francesca · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

Authors: Zagari, Francesca

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/84627

Thesis OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up

Tissot, Stéphanie · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up

Authors: Tissot, Stéphanie

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/68752

Thesis Study of transposon-mediated cell pool and cell line generation in CHO cells

Balasubramanian, Sowmya · 2015 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Study of transposon-mediated cell pool and cell line generation in CHO cells

Authors: Balasubramanian, Sowmya

Year: 2015

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/113896

Thesis Influence of cell-line and process conditions on the glycosylation of recombinant proteins

Nahrgang, Stefan · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Influence of cell-line and process conditions on the glycosylation of recombinant proteins

Authors: Nahrgang, Stefan

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/211632

Thesis Transient gene expression for rapid protein production : studies & optimizations under serum-free conditions

Muller, Natalie · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Transient gene expression for rapid protein production : studies & optimizations under serum-free conditions

Authors: Muller, Natalie

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/214287

Thesis ELUCIDATING MAMMALIAN CELL METABOLISM USING ‘OMICS TO ENHANCE BIOPROCESS CAPABILITIES

Dhara, Venkata Gayatri · 2022 · Johns Hopkins University · DOI

Full title: ELUCIDATING MAMMALIAN CELL METABOLISM USING ‘OMICS TO ENHANCE BIOPROCESS CAPABILITIES

Authors: Dhara, Venkata Gayatri

Year: 2022

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/66775

Thesis CELL ENGINEERING AND CULTURE MEDIA MODIFICATION STUDIES TO IMPROVE THE CELL CULTURE PERFORMANCE

Dhara, Venkata Gayatri · 2019 · Johns Hopkins University · DOI

Full title: CELL ENGINEERING AND CULTURE MEDIA MODIFICATION STUDIES TO IMPROVE THE CELL CULTURE PERFORMANCE

Authors: Dhara, Venkata Gayatri

Year: 2019

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/60428

Thesis Glycoengineering of Chinese Hamster Ovary cells for improving biotherapeutics’ efficacies.

Chung, Cheng-yu · 2019 · Johns Hopkins University · DOI

Full title: Glycoengineering of Chinese Hamster Ovary cells for improving biotherapeutics’ efficacies.

Authors: Chung, Cheng-yu

Year: 2019

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/60731

Thesis Predictive models for upstream mammalian cell culture development: a review

Yatipanthalawa, BS; Gras, SL · 2023 · University of Melbourne · DOI

Full title: Predictive models for upstream mammalian cell culture development: a review

Authors: Yatipanthalawa, BS; Gras, SL

Year: 2023

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/339523

Thesis Rapid Media Transition for Metabolic Control Analysis of Fed-Batch Fermentation Processes

Link, Hannes Peter · 2009 · Technical University of Munich · DOI

Full title: Rapid Media Transition for Metabolic Control Analysis of Fed-Batch Fermentation Processes

Authors: Link, Hannes Peter

Year: 2009

Venue: Technical University of Munich

DOI: https://mediatum.ub.tum.de/796895

Thesis Probing Control : Analysis and Design with Application to Fed-Batch Bioreactors

Velut, Stéphane · 2005 · Lund University (LUP) · DOI

Full title: Probing Control : Analysis and Design with Application to Fed-Batch Bioreactors

Authors: Velut, Stéphane

Year: 2005

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/24605

Thesis Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Hong, Moo Sun · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Authors: Hong, Moo Sun

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/138943

Thesis Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing

Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP] et al. · 2019 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing

Authors: Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP]; Deffune, Elenice; Suazo, Cláudio Alberto Torres

Year: 2019

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1590/0104-6632.20180352s20160463

Thesis Model comparison to describe BHK-21 cell growth and metabolism in stirred tank bioreactors operated in batch mode

Fernández Núñez, Eutimio Gustavo · 2018 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Model comparison to describe BHK-21 cell growth and metabolism in stirred tank bioreactors operated in batch mode

Authors: Fernández Núñez, Eutimio Gustavo

Year: 2018

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.1590/0104-6632.20180352s20160592

Thesis NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods

De Leoz, Maria Lorna A; Duewer, David L; Fung, Adam et al. · 2020 · Utrecht University · DOI

Full title: NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods

Authors: De Leoz, Maria Lorna A; Duewer, David L; Fung, Adam; Liu, Lily; Yau, Hoi Kei; Potter, Oscar; Staples, Gregory O; Furuki, Kenichiro; Frenkel, Ruth; Hu, Yunli; Sosic, Zoran; Zhang, Peiqing; Altmann, Friedrich; Gru Nwald-Grube, Clemens; Shao, Chun; Zaia, Joseph; Evers, Waltraud; Pengelley, Stuart; Suckau, Detlev; Wiechmann, Anja; Resemann, Anja; Jabs, Wolfgang; Beck, Alain; Froehlich, John W; Huang, Chuncui; Li, Yan; Liu, Yaming; Sun, Shiwei; Wang, Yaojun; Seo, Youngsuk; An, Hyun Joo; Reichardt, Niels-Christian; Ruiz, Juan Echevarria; Archer-Hartmann, Stephanie; Azadi, Parastoo; Bell, Len; Lakos, Zsuzsanna; An, Yanming; Cipollo, John F; Pucic-Bakovic, Maja; Štambuk, Jerko; Lauc, Gordan; Li, Xu; Wang, Peng George; Bock, Andreas; Yang, Shuang; Lee, Ju Yeon; Heck, Albert J R; Yang, Yang; Haselberg, Rob

Year: 2020

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/394141

Thesis Automated pipeline for rapid production and screening of HIV-specific monoclonal antibodies using pichia pastoris

Shah, Kartik A; Clark, John J; Goods, Brittany A. et al. · 2017 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Automated pipeline for rapid production and screening of HIV-specific monoclonal antibodies using pichia pastoris

Authors: Shah, Kartik A; Clark, John J; Goods, Brittany A.; Politano, Timothy James; Mozdzierz, Nicholas Joseph; Zimnisky, Ross; Leeson, Rachel; Love, John C; Love, Kerry R.

Year: 2017

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/109438

Thesis Effect of adenosine and cordycepin on recombinant antibody production yields in two different Chinease hamster ovary cell lines

Jarusintanakorn, Salinthip; Rangnoi, Kuntalee; Yamabhai, Montarop et al. · 2024 · Utrecht University · DOI

Full title: Effect of adenosine and cordycepin on recombinant antibody production yields in two different Chinease hamster ovary cell lines

Authors: Jarusintanakorn, Salinthip; Rangnoi, Kuntalee; Yamabhai, Montarop; Mastrobattista, Enrico

Year: 2024

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/438035

Thesis Microfluidic Cell Retention Device for Perfusion of Mammalian Suspension Culture

Prentice, Holly; Warkiani, Majid Ebrahimi; Kwon, Taehong et al. · 2017 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Microfluidic Cell Retention Device for Perfusion of Mammalian Suspension Culture

Authors: Prentice, Holly; Warkiani, Majid Ebrahimi; Kwon, Taehong; De Oliveira, Jonas; Madziva, Nyasha; Hamel, Jean-Francois P; Han, Jongyoon

Year: 2017

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/112686

Thesis Small-molecule control of antibody N-glycosylation in engineered mammalian cells

Chang, Michelle; Gaidukov, Leonid; Jung, Giyoung et al. · 2020 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Small-molecule control of antibody N-glycosylation in engineered mammalian cells

Authors: Chang, Michelle; Gaidukov, Leonid; Jung, Giyoung; Tseng, Wen Allen; Scarcelli, John J.; Cornell, Richard; Marshall, Jeffrey K.; Lyles, Jonathan L; Sakorafas, Paul; Chu, An-Hsiang Adam; Cote, Kaffa; Tzvetkova, Boriana; Dolatshahi, Sepideh; Sumit, Madhuresh; Mulukutla, Bhanu Chandra; Lauffenburger, Douglas A; Figueroa, Bruno; Summers, Nevin M; Lu, Timothy K; Weiss, Ron

Year: 2020

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/125977

Thesis Investigating the influence of physiologically relevant hydrostatic pressure on CHO cell batch culture

Shang, Menglin; Kwon, Taehong; Hamel, Jean-Francois P et al. · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Investigating the influence of physiologically relevant hydrostatic pressure on CHO cell batch culture

Authors: Shang, Menglin; Kwon, Taehong; Hamel, Jean-Francois P; Lim, Chwee Teck; Khoo, Bee Luan; Han, Jongyoon

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/143608

Thesis Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe et al. · 2016 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

Authors: López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe; Carrillo-Cocom, Leydi Maribel; Rocha-Pizaña, María del Refugio; Alvarez, Mario Moises

Year: 2016

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/105504

Thesis Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

Sumit, Madhuresh; Dolatshahi, Sepideh; Chu, An-Hsiang Adam et al. · 2020 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

Authors: Sumit, Madhuresh; Dolatshahi, Sepideh; Chu, An-Hsiang Adam; Cote, Kaffa; Scarcelli, John J.; Marshall, Jeffrey K.; Cornell, Richard J.; Weiss, Ron; Lauffenburger, Douglas A.; Mulukutla, Bhanu Chandra; Figueroa, Bruno

Year: 2020

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/125974

Thesis A multi-landing pad DNA integration platform for mammalian cell engineering

Wroblewska, Liliana; Nelson, Tom; Zhang, Xin et al. · 2018 · Massachusetts Institute of Technology (MIT) · DOI

Full title: A multi-landing pad DNA integration platform for mammalian cell engineering

Authors: Wroblewska, Liliana; Nelson, Tom; Zhang, Xin; Liu, Yan; Lowe, Alexis; Bandara, Kalpanie; Baijuraj, Swetha; Zhang, Lin; Gaydukov, Leonid A.; Teague, Brian Paul; Jagtap, Kalpana P; Mamo, Selamawit W; Tseng, Wen Allen; Das, Jishnu; Summers, Nevin M; Lu, Timothy K; Weiss, Ron

Year: 2018

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/115278

Thesis Preemptive variation reduction in biologic drug substance manufacturing

Güereca Valdivia, Ismael · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Preemptive variation reduction in biologic drug substance manufacturing

Authors: Güereca Valdivia, Ismael

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/155982

Thesis Industry 4.0 in Biomanufacturing: Predictive Real-Time Models Using Process Analytical Technology

Murr, Michaela · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Industry 4.0 in Biomanufacturing: Predictive Real-Time Models Using Process Analytical Technology

Authors: Murr, Michaela

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/151710

Thesis Continuous Online Protein Quality Monitoring during Perfusion Culture Production Using an Integrated Micro/Nanofluidic System

Kwon, Taehong; Ko, Sung Hee; Hamel, Jean-Francois P et al. · 2020 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Continuous Online Protein Quality Monitoring during Perfusion Culture Production Using an Integrated Micro/Nanofluidic System

Authors: Kwon, Taehong; Ko, Sung Hee; Hamel, Jean-Francois P; Han, Jongyoon

Year: 2020

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/125538

Thesis An Investigation of Multivariate Process Control for Biomanufacturing

Lui, Christopher A. · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: An Investigation of Multivariate Process Control for Biomanufacturing

Authors: Lui, Christopher A.

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/139505

Thesis Challenging the workhorse: Comparative analysis of eukaryotic micro‐organisms for expressing monoclonal antibodies

Jiang, Hanxiao; Horwitz, Andrew A; Wright, Chapman et al. · 2021 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Challenging the workhorse: Comparative analysis of eukaryotic micro‐organisms for expressing monoclonal antibodies

Authors: Jiang, Hanxiao; Horwitz, Andrew A; Wright, Chapman; Tai, Anna; Znameroski, Elizabeth A; Tsegaye, Yoseph; Warbington, Hailley; Bower, Benjamin S; Alves, Christina; Co, Carl; Jonnalagadda, Kanvasri; Platt, Darren; Walter, Jessica M; Natarajan, Venkatesh; Ubersax, Jeffrey A; Cherry, Joel R; Love, J Christopher

Year: 2021

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/134784

Thesis Enhancing Production of Recombinant Proteins from Mammalian Cells

Wong, Victor V.T.; Wong, Niki S.C.; Tan, Hong-Kiat et al. · 2003 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Enhancing Production of Recombinant Proteins from Mammalian Cells

Authors: Wong, Victor V.T.; Wong, Niki S.C.; Tan, Hong-Kiat; Wang, Daniel I.C.; Yap, Miranda G.S.

Year: 2003

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/3782

Thesis Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in Komagataella phaffii

Yang, Yuchen; Dalvie, Neil C; Brady, Joseph R et al. · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in Komagataella phaffii

Authors: Yang, Yuchen; Dalvie, Neil C; Brady, Joseph R; Naranjo, Christopher A; Lorgeree, Timothy; Rodriguez‐Aponte, Sergio A; Johnston, Ryan S; Tracey, Mary K; Elenberger, Carmen M; Lee, Eric; Tié, Mark; Love, Kerry R; Love, J Christopher

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/163225

Thesis Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool

Puarattana-aroonkorn, Sitthiphol; Tharakaraman, Kannan; Suriyawipada, Disapan et al. · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool

Authors: Puarattana-aroonkorn, Sitthiphol; Tharakaraman, Kannan; Suriyawipada, Disapan; Ruchirawat, Mathuros; Fuangthong, Mayuree; Sasisekharan, Ram; Artpradit, Charlermchai

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/155543

Thesis Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel et al. · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Authors: Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel; Dang, Brendan; Wolffe, Lenna A; Atari, Adel; Tseng, Yuen-Yi; Love, J Christopher

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/163220

Thesis Active Hypothermic Growth: A Novel Means For Increasing Total Interferon-γ Production by Chinese Hamster Ovary Cells

Stephen R., Fox; Yap, Mei Xia; Yap, Miranda G.S. et al. · 2005 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Active Hypothermic Growth: A Novel Means For Increasing Total Interferon-γ Production by Chinese Hamster Ovary Cells

Authors: Stephen R., Fox; Yap, Mei Xia; Yap, Miranda G.S.; Wang, Daniel I.C.

Year: 2005

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/30379

Thesis The Effect of Culture Temperature on Recombinant IFN-γ Production and Quality

Fox, Steven R.; Yap, Miranda G.S.; Wang, Daniel I.C. · 2003 · Massachusetts Institute of Technology (MIT) · DOI

Full title: The Effect of Culture Temperature on Recombinant IFN-γ Production and Quality

Authors: Fox, Steven R.; Yap, Miranda G.S.; Wang, Daniel I.C.

Year: 2003

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/3928

Thesis CIRP Expression on Growth and Productivity of CHO Cells

Tan, Hong-Kiat; Yap, Miranda G.S.; Wang, Daniel I.C. · 2005 · Massachusetts Institute of Technology (MIT) · DOI

Full title: CIRP Expression on Growth and Productivity of CHO Cells

Authors: Tan, Hong-Kiat; Yap, Miranda G.S.; Wang, Daniel I.C.

Year: 2005

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/30382

Thesis Reduced Temperature Production of Recombinant Proteins to Increase Productivity in Mammalian Cell Culture

Fox, Steven R.; Wang, Daniel I.C.; Yap, Miranda G.S. · 2003 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Reduced Temperature Production of Recombinant Proteins to Increase Productivity in Mammalian Cell Culture

Authors: Fox, Steven R.; Wang, Daniel I.C.; Yap, Miranda G.S.

Year: 2003

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/3946

Thesis Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins

Bosques, Carlos J.; Collins, Brian E.; Meador, James W. et al. · 2014 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins

Authors: Bosques, Carlos J.; Collins, Brian E.; Meador, James W.; Sarvaiya, Hetal; Murphy, Jennifer L.; DelloRusso, Guy; Bulik, Dorota A.; Hsu, I-Hsuan; Washburn, Nathaniel; Sipsey, Sandra F.; Myette, James R.; Raman, Rahul; Sasisekharan, Ram; Venkataraman, Ganesh; Shriver, Zachary H.

Year: 2014

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/89032

Thesis Variability in the Stability and Productivity of Transfected Genes in Chinese Hamster Ovary (CHO) cells

Ng, Say Kong; Yap, Miranda G.S.; Wang, Daniel I.C. · 2004 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Variability in the Stability and Productivity of Transfected Genes in Chinese Hamster Ovary (CHO) cells

Authors: Ng, Say Kong; Yap, Miranda G.S.; Wang, Daniel I.C.

Year: 2004

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/7504

Thesis Naming CHO cells for bio-manufacturing: Genome plasticity and variant phenotypes of cell populations in bioreactors question the relevance of old names

Wurm, Maria J.; Wurm, Florian M. · 2021 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Naming CHO cells for bio-manufacturing: Genome plasticity and variant phenotypes of cell populations in bioreactors question the relevance of old names

Authors: Wurm, Maria J.; Wurm, Florian M.

Year: 2021

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/179941

Thesis Trimeric SARS-CoV-2 Spike Proteins Produced from CHO Cells in Bioreactors Are High-Quality Antigens

Pino, Paco; Kint, Joeri; Kiseljak, Divor et al. · 2021 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Trimeric SARS-CoV-2 Spike Proteins Produced from CHO Cells in Bioreactors Are High-Quality Antigens

Authors: Pino, Paco; Kint, Joeri; Kiseljak, Divor; Agnolon, Valentina; Corradin, Giampietro; Kajava, Andrey V.; Rovero, Paolo; Dijkman, Ronald; den Hartog, Gerco; McLellan, Jason S.; Byrne, Patrick O.; Wurm, Maria J.; Wurm, Florian M.

Year: 2021

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/174671

Thesis Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection-A Simulation Study

Hernandez Rodriguez, Tanja; Morerod, Sophie; Poertner, Ralf et al. · 2021 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection-A Simulation Study

Authors: Hernandez Rodriguez, Tanja; Morerod, Sophie; Poertner, Ralf; Wurm, Florian M.; Frahm, Bjorn

Year: 2021

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/180009

Thesis A Robust, High-Titer, Semi-Automated, and In-Culture Antibody-Capturing Transient CHO Platform Technology

Gebhardt, L. P.; Abel, Molica; Zhou, Jing et al. · 2025 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A Robust, High-Titer, Semi-Automated, and In-Culture Antibody-Capturing Transient CHO Platform Technology

Authors: Gebhardt, L. P.; Abel, Molica; Zhou, Jing; Vogt, A; Shin, Bo Hee; Wagman, Sarah L. Herrick; Santos, Ana Luísa; Puginier, Jerome; Wurm, Florian Μ.; Wurm, Florian Μ.; Yan, Guoying; Adeniyi, Ade Fatai; Lim, Sean K. H.; Somers, Will; Lin, Laura; D’Antona, Aaron M.; Zhong, Xiaotian

Year: 2025

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/255058

Thesis Cloning of CHO Cells, Productivity and Genetic Stability—A Discussion

Wurm, Florian · 2020 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Cloning of CHO Cells, Productivity and Genetic Stability—A Discussion

Authors: Wurm, Florian

Year: 2020

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/169672

Thesis Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

Muller, N.; Derouazi, M.; Van Tilborgh, F. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

Authors: Muller, N.; Derouazi, M.; Van Tilborgh, F.; Wulhfard, S.; Hacker, D. L.; Jordan, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9754

Thesis A new approach for identifying positional isomers of glycans cleaved from monoclonal antibodies

Dyukova, Irina; Ben Faleh, Ahmed; Warnke, Stephan et al. · 2021 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A new approach for identifying positional isomers of glycans cleaved from monoclonal antibodies

Authors: Dyukova, Irina; Ben Faleh, Ahmed; Warnke, Stephan; Yalovenko, Natalia; Yatsyna, Vasyl; Bansal, Priyanka; Rizzo, Thomas R.

Year: 2021

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/179989

Thesis Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

Zhang, Xiaowei; Garcia, Isabel Fernandez; Baldi, Lucia et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

Authors: Zhang, Xiaowei; Garcia, Isabel Fernandez; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/52051

Thesis Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells

Davami, Fatemeh; Baldi, Lucia; Rajendra, Yashas et al. · 2014 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells

Authors: Davami, Fatemeh; Baldi, Lucia; Rajendra, Yashas; M Wurm, Florian

Year: 2014

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/108905

Thesis Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells

Meuwly, F.; von Stockar, U.; Kadouri, A. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells

Authors: Meuwly, F.; von Stockar, U.; Kadouri, A.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226104

Thesis OVEREXPRESSION OF SLC15A1 GENE IN CHO-S CELLS TO INCREASE DIPEPTIDE UPTAKE RATE

Liu, Shuman · 2021 · Johns Hopkins University · DOI

Full title: OVEREXPRESSION OF SLC15A1 GENE IN CHO-S CELLS TO INCREASE DIPEPTIDE UPTAKE RATE

Authors: Liu, Shuman

Year: 2021

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/64522

Thesis HIGH EFFICIENCY AFFINITY CAPTURE AND PURIFICATION OF IMMUNOGLOBULIN G USING MAGNETIC PARTICLES WITH BIOINSPIRIED PEPTIDE LIGANDS

Ou, Shih-Hao · 2019 · Johns Hopkins University · DOI

Full title: HIGH EFFICIENCY AFFINITY CAPTURE AND PURIFICATION OF IMMUNOGLOBULIN G USING MAGNETIC PARTICLES WITH BIOINSPIRIED PEPTIDE LIGANDS

Authors: Ou, Shih-Hao

Year: 2019

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/61606

Thesis Optimization of Recombinant Protein Production in Different Cell Lines

Ouyang, Chu · 2024 · Johns Hopkins University · DOI

Full title: Optimization of Recombinant Protein Production in Different Cell Lines

Authors: Ouyang, Chu

Year: 2024

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/69633

Thesis Improvement of Erythropoietin N-glycan Branching and Sialylation by Overexpression of Glycosyltransferases

Gao, Yuan · 2016 · Johns Hopkins University · DOI

Full title: Improvement of Erythropoietin N-glycan Branching and Sialylation by Overexpression of Glycosyltransferases

Authors: Gao, Yuan

Year: 2016

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/39421

Thesis Screening for Antibody Reduction at the Clone Selection Stage to Prevent Reduction During Manufacturing

Lakhani, Aliya Abdulaziz · 2019 · Johns Hopkins University · DOI

Full title: Screening for Antibody Reduction at the Clone Selection Stage to Prevent Reduction During Manufacturing

Authors: Lakhani, Aliya Abdulaziz

Year: 2019

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/60150

Thesis Protocol for production and expression of chimeric bovine-human monoclonal antibodies

Heydarchi, B; Purcell, DFJ · 2023 · University of Melbourne · DOI

Full title: Protocol for production and expression of chimeric bovine-human monoclonal antibodies

Authors: Heydarchi, B; Purcell, DFJ

Year: 2023

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/334751

Thesis Production and characterization of specific monoclonal antibodies binding the Plasmodium falciparum diagnostic biomarker, histidine-rich protein 2

Leow, CH; Jones, M; Cheng, Q et al. · 2021 · University of Melbourne · DOI

Full title: Production and characterization of specific monoclonal antibodies binding the Plasmodium falciparum diagnostic biomarker, histidine-rich protein 2

Authors: Leow, CH; Jones, M; Cheng, Q; Mahler, S; McCarthy, J

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/277268

Thesis Impact on product quality of high productive GS-CHO cell lines.

Perani, A; Gloria, B; Wang, D et al. · 2022 · University of Melbourne · DOI

Full title: Impact on product quality of high productive GS-CHO cell lines.

Authors: Perani, A; Gloria, B; Wang, D; Murphy, R; Singh, HK; Smyth, FE; Scott, AM

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/303930

Thesis A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments

Karimi Alavijeh, M; Lee, YY; Gras, SL · 2024 · University of Melbourne · DOI

Full title: A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments

Authors: Karimi Alavijeh, M; Lee, YY; Gras, SL

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/351093

Thesis Variations in critical quality attributes (CQAs) on therapeutic monoclonal antibodies (mAbs) due to cultivation conditions, storage conditions and external stress-factors

Nash, Felicia; Sannum, Emma · 2024 · Lund University Student Papers · DOI

Full title: Variations in critical quality attributes (CQAs) on therapeutic monoclonal antibodies (mAbs) due to cultivation conditions, storage conditions and external stress-factors

Authors: Nash, Felicia; Sannum, Emma

Year: 2024

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9170581

Thesis Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand

Chua, Gek Kee · 2011 · Massey University · DOI

Full title: Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand

Authors: Chua, Gek Kee

Year: 2011

Venue: Massey University

DOI: http://hdl.handle.net/10179/2832

Thesis FIA-Based Process Monitoring in Simulated Bioreactor for Monoclonal Antibody Production

Fernandez Alcantara, Leonardo Renzo · 2025 · Lund University Student Papers · DOI

Full title: FIA-Based Process Monitoring in Simulated Bioreactor for Monoclonal Antibody Production

Authors: Fernandez Alcantara, Leonardo Renzo

Year: 2025

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9188201

Thesis Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening

Kim, Su Hyun; Shin, Seunghyeon; Baek, Minhye et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening

Authors: Kim, Su Hyun; Shin, Seunghyeon; Baek, Minhye; Xiong, Kai; Karottki, Karen Julie la Cour; Hefzi, Hooman; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Kildegaard, Helene Faustrup; Lewis, Nathan E.; Lee, Jae Seong; Lee, Gyun Min

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/6d4a73c5-e3ad-45bb-bdcf-fcad2d316ad4

Thesis Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium

Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Òdena, Andreu et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium

Authors: Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Òdena, Andreu; Karottki, Karen Julie la Cour; Kim, Che Lin; Hefzi, Hooman; Lee, Gyun Min; Faustrup Kildegaard, Helene; Nielsen, Lars K.; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lewis, Nathan E.

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9841cea8-7f15-4ec0-9c98-bc7dea65684a

Thesis Optimization of serum free medium for the production of humanized anti-cea monoclonal antibody.

Ab Latif, Nurzila · 2011 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Optimization of serum free medium for the production of humanized anti-cea monoclonal antibody.

Authors: Ab Latif, Nurzila

Year: 2011

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/26510/2/IB%202011%2030R.pdf

Thesis A versatile genomic transgenesis platform with enhanced λ integrase for human Expi293F cells

Siddiqui, Asim Azhar (Nanyang Technological University); Dröge, Peter (Nanyang Technological University); Günzburg, Walter H. (University of Veterinary Medicine Vienna / Austrianova Singapore Pte. Ltd.) et al. · 2023 · University of Veterinary Medicine Vienna (Vetmeduni Vienna) · DOI

Full title: A versatile genomic transgenesis platform with enhanced λ integrase for human Expi293F cells

Authors: Siddiqui, Asim Azhar (Nanyang Technological University); Dröge, Peter (Nanyang Technological University); Günzburg, Walter H. (University of Veterinary Medicine Vienna / Austrianova Singapore Pte. Ltd.); Dangerfield, John A. (Austrianova Singapore Pte. Ltd.); Ng, Shirelle (Austrianova Singapore Pte. Ltd.); Wang, Cheng-I (Agency for Science, Technology and Research (A*STAR)); Peter, Sabrina (Nanyang Technological University); Ngoh, Eve Zi Xian (Agency for Science, Technology and Research (A*STAR))

Year: 2023

Venue: University of Veterinary Medicine Vienna (Vetmeduni Vienna)

DOI: https://phaidra.vetmeduni.ac.at/o:2395

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Year: 2016

Metadata only

Paper Glycoprotein (GP) Ib-IX-transfected Cells Roll on a von Willebrand Factor Matrix under Flow

Cranmer, Susan L.; Ulsemer, Philippe; Cooke, Brian M. et al. · 1999 · Journal of Biological Chemistry · DOI

Full title: Glycoprotein (GP) Ib-IX-transfected Cells Roll on a von Willebrand Factor Matrix under Flow

Authors: Cranmer, Susan L.; Ulsemer, Philippe; Cooke, Brian M.; Salem, Hatem H.; Salle, C de la; Lanza, François; Jackson, Shaun P.

Year: 1999

Venue: Journal of Biological Chemistry

DOI: https://doi.org/10.1074/jbc.274.10.6097

Paper Development of a novel mammalian display system for selection of antibodies against membrane proteins.

N. Robertson; Nancy López-Antón; S. Gurjar et al. · 2020 · Journal of Biological Chemistry · DOI

Full title: Development of a novel mammalian display system for selection of antibodies against membrane proteins.

Authors: N. Robertson; Nancy López-Antón; S. Gurjar; H. Khalique; Zainab Khalaf; Siobhan Clerkin; Vaughan R. Leydon; R. Parker-Manuel; A. Raeside; T. Payne; T. Jones; L. Seymour; R. Cawood

Year: 2020

Venue: Journal of Biological Chemistry

DOI: https://doi.org/10.1074/jbc.ra120.015053

Paper The use of site-specific recombination and cassette exchange technologies for monoclonal antibody production in Chinese Hamster ovary cells: retrospective analysis and future directions

Srirangan, Kajan; Loignon, Martin; Durocher, Yves · 2020 · Critical Reviews in Biotechnology · DOI

Full title: The use of site-specific recombination and cassette exchange technologies for monoclonal antibody production in Chinese Hamster ovary cells: retrospective analysis and future directions

Authors: Srirangan, Kajan; Loignon, Martin; Durocher, Yves

Year: 2020

Venue: Critical Reviews in Biotechnology

DOI: https://doi.org/10.1080/07388551.2020.1768043

Paper Ultrafast and high-throughput N-glycan analysis for monoclonal antibodies

Xiaoyu Yang; Sunnie Kim; Richard Ruzanski et al. · 2016 · mAbs · DOI

Full title: Ultrafast and high-throughput N-glycan analysis for monoclonal antibodies

Authors: Xiaoyu Yang; Sunnie Kim; Richard Ruzanski; Yuetian Chen; S. Moses; W. L. Ling; Xiaojuan Li; Shaoxiong Wang; Huijuan Li; A. Ambrogelly; Daisy Richardson; M. Shameem

Year: 2016

Venue: mAbs

DOI: https://doi.org/10.1080/19420862.2016.1156828

Paper Process intensification in fed-batch production bioreactors using non-perfusion seed cultures.

Yongky, Andrew; Xu, Jianlin; Tian, Jun et al. · 2019 · mAbs · DOI

Full title: Process intensification in fed-batch production bioreactors using non-perfusion seed cultures.

Authors: Yongky, Andrew; Xu, Jianlin; Tian, Jun; Oliveira, Christopher; Zhao, Jia; McFarland, Kevin; Borys, Michael C; Li, Zheng Jian

Year: 2019

Venue: mAbs

DOI: https://doi.org/10.1080/19420862.2019.1652075

Paper Enabling speed to clinic for monoclonal antibody programs using a pool of clones for IND-enabling toxicity studies.

Bolisetty, Parimala; Tremml, Gabi; Xu, Sen et al. · 2020 · mAbs · DOI

Full title: Enabling speed to clinic for monoclonal antibody programs using a pool of clones for IND-enabling toxicity studies.

Authors: Bolisetty, Parimala; Tremml, Gabi; Xu, Sen; Khetan, Anurag

Year: 2020

Venue: mAbs

DOI: https://doi.org/10.1080/19420862.2020.1763727

Paper A long non-coding SINEUP RNA boosts semi-stable production of fully human monoclonal antibodies in HEK293E cells

E. Sasso; D. Latino; G. Froechlich et al. · 2018 · mAbs · DOI

Full title: A long non-coding SINEUP RNA boosts semi-stable production of fully human monoclonal antibodies in HEK293E cells

Authors: E. Sasso; D. Latino; G. Froechlich; Mariangela Succoio; M. Passariello; C. De Lorenzo; A. Nicosia; N. Zambrano

Year: 2018

Venue: mAbs

DOI: https://doi.org/10.1080/19420862.2018.1463945

Paper High-throughput single-cell screening of viable hybridomas and patient-derived antibody-secreting cells using punchable microwells

Kaat Rubben; Ann-Sophie Vander Plaetsen; Ruben Almey et al. · 2024 · Artificial Cells Nanomedicine and Biotechnology · DOI

Full title: High-throughput single-cell screening of viable hybridomas and patient-derived antibody-secreting cells using punchable microwells

Authors: Kaat Rubben; Ann-Sophie Vander Plaetsen; Ruben Almey; O. Tytgat; Koen Deserranno; Jamie Debaere; Delphine Diana Acar; Philip Meuleman; D. Deforce; F. van Nieuwerburgh

Year: 2024

Venue: Artificial Cells Nanomedicine and Biotechnology

DOI: https://doi.org/10.1080/21691401.2024.2395815

Paper The Augmenting Effects of the tDNA Insulator on Stable Expression of Monoclonal Antibody in Chinese Hamster Ovary Cells.

Naderi, Fatemeh; Hashemi, Mehrdad; Bayat, Hadi et al. · 2018 · Monoclonal antibodies in immunodiagnosis and immunotherapy · DOI

Full title: The Augmenting Effects of the tDNA Insulator on Stable Expression of Monoclonal Antibody in Chinese Hamster Ovary Cells.

Authors: Naderi, Fatemeh; Hashemi, Mehrdad; Bayat, Hadi; Mohammadian, Omid; Pourmaleki, Es'hagh; Etemadzadeh, Mohammad Hossein; Rahimpour, Azam

Year: 2018

Venue: Monoclonal antibodies in immunodiagnosis and immunotherapy

DOI: https://doi.org/10.1089/mab.2018.0015

Paper Aggresomes: A Cellular Response to Misfolded Proteins

Johnston, Jennifer; Ward, Cristina L.; Kopito, Ron R. · 1998 · The Journal of Cell Biology · DOI

Full title: Aggresomes: A Cellular Response to Misfolded Proteins

Authors: Johnston, Jennifer; Ward, Cristina L.; Kopito, Ron R.

Year: 1998

Venue: The Journal of Cell Biology

DOI: https://doi.org/10.1083/jcb.143.7.1883

Paper Development of an Anti-Sheep Podoplanin Monoclonal Antibody PMab-256 for Immunohistochemical Analysis of Lymphatic Endothelial Cells

Y. Kato; Yoshikazu Furusawa; M. Sano et al. · 2020 · Monoclonal antibodies in immunodiagnosis and immunotherapy · DOI

Full title: Development of an Anti-Sheep Podoplanin Monoclonal Antibody PMab-256 for Immunohistochemical Analysis of Lymphatic Endothelial Cells

Authors: Y. Kato; Yoshikazu Furusawa; M. Sano; Junko Takei; Takuro Nakamura; Miyuki Yanaka; Saki Okamoto; Saori Handa; Yu Komatsu; Teizo Asano; Yusuke Sayama; M. Kaneko

Year: 2020

Venue: Monoclonal antibodies in immunodiagnosis and immunotherapy

DOI: https://doi.org/10.1089/mab.2020.0005

Paper Recombinant soluble human Fc gamma RII: production, characterization, and inhibition of the Arthus reaction.

Ierino, Frank; Powell, Maree S.; McKenzie, I F et al. · 1993 · The Journal of Experimental Medicine · DOI

Full title: Recombinant soluble human Fc gamma RII: production, characterization, and inhibition of the Arthus reaction.

Authors: Ierino, Frank; Powell, Maree S.; McKenzie, I F; Hogarth, P. Mark

Year: 1993

Venue: The Journal of Experimental Medicine

DOI: https://doi.org/10.1084/jem.178.5.1617

Paper Development of an Anti-Elephant Podoplanin Monoclonal Antibody PMab-265 for Flow Cytometry

Hideki Hosono; Teizo Asano; Junko Takei et al. · 2021 · Monoclonal antibodies in immunodiagnosis and immunotherapy · DOI

Full title: Development of an Anti-Elephant Podoplanin Monoclonal Antibody PMab-265 for Flow Cytometry

Authors: Hideki Hosono; Teizo Asano; Junko Takei; M. Sano; Tomohiro Tanaka; M. Kaneko; Y. Kato

Year: 2021

Venue: Monoclonal antibodies in immunodiagnosis and immunotherapy

DOI: https://doi.org/10.1089/mab.2021.0015

Paper Development of a Sensitive Anti-Mouse CCR5 Monoclonal Antibody for Flow Cytometry

Hiroyuki Suzuki; Tomohiro Tanaka; Guanjie Li et al. · 2024 · Monoclonal antibodies in immunodiagnosis and immunotherapy · DOI

Full title: Development of a Sensitive Anti-Mouse CCR5 Monoclonal Antibody for Flow Cytometry

Authors: Hiroyuki Suzuki; Tomohiro Tanaka; Guanjie Li; Tsunenori Ouchida; M. Kaneko; Y. Kato

Year: 2024

Venue: Monoclonal antibodies in immunodiagnosis and immunotherapy

DOI: https://doi.org/10.1089/mab.2024.0004

Paper Development of Anti-Mouse CC Chemokine Receptor 8 Monoclonal Antibodies for Flow Cytometry

Tomohiro Tanaka; Ren Nanamiya; Junko Takei et al. · 2021 · Monoclonal antibodies in immunodiagnosis and immunotherapy · DOI

Full title: Development of Anti-Mouse CC Chemokine Receptor 8 Monoclonal Antibodies for Flow Cytometry

Authors: Tomohiro Tanaka; Ren Nanamiya; Junko Takei; Takuro Nakamura; Miyuki Yanaka; Hideki Hosono; M. Sano; Teizo Asano; M. Kaneko; Y. Kato

Year: 2021

Venue: Monoclonal antibodies in immunodiagnosis and immunotherapy

DOI: https://doi.org/10.1089/mab.2021.0005

Paper Development and Characterization of Anti-Sheep Podoplanin Monoclonal Antibodies PMab-253 and PMab-260

M. Kaneko; M. Sano; Junko Takei et al. · 2020 · Monoclonal antibodies in immunodiagnosis and immunotherapy · DOI

Full title: Development and Characterization of Anti-Sheep Podoplanin Monoclonal Antibodies PMab-253 and PMab-260

Authors: M. Kaneko; M. Sano; Junko Takei; Teizo Asano; Yusuke Sayama; Hideki Hosono; Atsushi Kobayashi; S. Konnai; Y. Kato

Year: 2020

Venue: Monoclonal antibodies in immunodiagnosis and immunotherapy

DOI: https://doi.org/10.1089/mab.2020.0018

Paper Establishment of a Novel Anti-Mouse CCR1 Monoclonal Antibody C1Mab-6

Tsunenori Ouchida; Yumi Isoda; Takuro Nakamura et al. · 2024 · Monoclonal antibodies in immunodiagnosis and immunotherapy · DOI

Full title: Establishment of a Novel Anti-Mouse CCR1 Monoclonal Antibody C1Mab-6

Authors: Tsunenori Ouchida; Yumi Isoda; Takuro Nakamura; Miyuki Yanaka; Tomohiro Tanaka; Saori Handa; M. Kaneko; Hiroyuki Suzuki; Y. Kato

Year: 2024

Venue: Monoclonal antibodies in immunodiagnosis and immunotherapy

DOI: https://doi.org/10.1089/mab.2023.0032

Paper On enzymatic remodeling of IgG glycosylation; unique tools with broad applications

Sjögren, Jonathan; Lood, Rolf; Nägeli, Andreas · 2019 · Glycobiology · DOI

Full title: On enzymatic remodeling of IgG glycosylation; unique tools with broad applications

Authors: Sjögren, Jonathan; Lood, Rolf; Nägeli, Andreas

Year: 2019

Venue: Glycobiology

DOI: https://doi.org/10.1093/glycob/cwz085

Paper Understanding the role of antibody glycosylation through the lens of severe viral and bacterial diseases

Irvine, Edward B.; Alter, Galit · 2020 · Glycobiology · DOI

Full title: Understanding the role of antibody glycosylation through the lens of severe viral and bacterial diseases

Authors: Irvine, Edward B.; Alter, Galit

Year: 2020

Venue: Glycobiology

DOI: https://doi.org/10.1093/glycob/cwaa018

Paper Production of non-fucosylated antibodies by co-expression of heterologous GDP-6-deoxy-D-lyxo-4-hexulose reductase

Horsten, Hans Henning von; Ogorek, Christiane; Blanchard, Véronique et al. · 2010 · Glycobiology · DOI

Full title: Production of non-fucosylated antibodies by co-expression of heterologous GDP-6-deoxy-D-lyxo-4-hexulose reductase

Authors: Horsten, Hans Henning von; Ogorek, Christiane; Blanchard, Véronique; Demmler, C.D.; Giese, Christoph; Winkler, Karsten; Kaup, M.; Berger, Markus; Jordan, Ingo; Sandig, Volker

Year: 2010

Venue: Glycobiology

DOI: https://doi.org/10.1093/glycob/cwq109

Paper Identification of high affinity HER2 binding antibodies using CHO Fab surface display

Annalee W. Nguyen; Kevin C. Le; J. Maynard · 2018 · Protein engineering, design & selection : PEDS · DOI

Full title: Identification of high affinity HER2 binding antibodies using CHO Fab surface display

Authors: Annalee W. Nguyen; Kevin C. Le; J. Maynard

Year: 2018

Venue: Protein engineering, design & selection : PEDS

DOI: https://doi.org/10.1093/protein/gzy004

Paper A general method for the selection of high-level scFv and IgG antibody expression by stably transfected mammalian cells

Zuberbühler, Klaus; Palumbo, Alessandro; Bacci, Cristina et al. · 2008 · Protein Engineering Design and Selection · DOI

Full title: A general method for the selection of high-level scFv and IgG antibody expression by stably transfected mammalian cells

Authors: Zuberbühler, Klaus; Palumbo, Alessandro; Bacci, Cristina; Giovannoni, Leonardo; Sommavilla, Roberto; Kaspar, M.; Trachsel, Eveline; Neri, Dario

Year: 2008

Venue: Protein Engineering Design and Selection

DOI: https://doi.org/10.1093/protein/gzn068

Paper Heterologous protein production using euchromatin-containing expression vectors in mammalian cells

Zboray, Katalin; Sommeregger, Wolfgang; Bogner, Edith et al. · 2015 · Nucleic Acids Research · DOI

Full title: Heterologous protein production using euchromatin-containing expression vectors in mammalian cells

Authors: Zboray, Katalin; Sommeregger, Wolfgang; Bogner, Edith; Gili, Andreas; Sterovsky, Thomas; Fauland, Katharina; Grabner, Beatrice; Stiedl, Patricia; Moll, Herwig P.; Bauer, Anton; Kunert, Renate; Casanova, Emilio

Year: 2015

Venue: Nucleic Acids Research

DOI: https://doi.org/10.1093/nar/gkv475

Paper Fc glycans of therapeutic antibodies as critical quality attributes

Reusch, Dietmar; Tejada, Max L. · 2015 · Glycobiology · DOI

Full title: Fc glycans of therapeutic antibodies as critical quality attributes

Authors: Reusch, Dietmar; Tejada, Max L.

Year: 2015

Venue: Glycobiology

DOI: https://doi.org/10.1093/glycob/cwv065

Paper A Microfluidic Chip for Screening High-Producing Hybridomas at the Single-Cell Level

Wei Zhang; Ren Li; Zhiguo Fang et al. · 2019 · IEEE/LEOS International Conference on Optical MEMS · DOI

Full title: A Microfluidic Chip for Screening High-Producing Hybridomas at the Single-Cell Level

Authors: Wei Zhang; Ren Li; Zhiguo Fang; Zhi Y. Hu; Zewen Wei; Qin Li

Year: 2019

Venue: IEEE/LEOS International Conference on Optical MEMS

DOI: https://doi.org/10.1109/memsys.2019.8870728

Paper Expression of Antibody Fragments with a ControlledN-Glycosylation Pattern and Induction of Endoplasmic Reticulum-Derived Vesicles in Seeds of Arabidopsis

Loos, Andreas; Droogenbroeck, Bart Van; Hillmer, Stefan et al. · 2011 · PLANT PHYSIOLOGY · DOI

Full title: Expression of Antibody Fragments with a ControlledN-Glycosylation Pattern and Induction of Endoplasmic Reticulum-Derived Vesicles in Seeds of Arabidopsis

Authors: Loos, Andreas; Droogenbroeck, Bart Van; Hillmer, Stefan; Grass, Josephine; Pabst, Martin; Castilho, Alexandra; Kunert, Renate; Liang, Mifang; Arcalís, Elsa; Robinson, David G.; Depicker, Ann; Steinkellner, Herta

Year: 2011

Venue: PLANT PHYSIOLOGY

DOI: https://doi.org/10.1104/pp.110.171330

Paper Structural and biological properties of human recombinant myeloperoxidase produced by Chinese hamster ovary cell lines

Moguilevsky, Nicole; Garcia-Quintana, Lida; Jacquet, Alain et al. · 1991 · European Journal of Biochemistry · DOI

Full title: Structural and biological properties of human recombinant myeloperoxidase produced by Chinese hamster ovary cell lines

Authors: Moguilevsky, Nicole; Garcia-Quintana, Lida; Jacquet, Alain; Tournay, Christophe; Fabry, L.; Piérard, L; Bollen, Alex

Year: 1991

Venue: European Journal of Biochemistry

DOI: https://doi.org/10.1111/j.1432-1033.1991.tb15950.x

Paper From gene to harvest: insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants.

M. Sack; T. Rademacher; H. Spiegel et al. · 2015 · Plant Biotechnology Journal · DOI

Full title: From gene to harvest: insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants.

Authors: M. Sack; T. Rademacher; H. Spiegel; A. Boes; S. Hellwig; J. Drossard; E. Stoger; R. Fischer

Year: 2015

Venue: Plant Biotechnology Journal

DOI: https://doi.org/10.1111/pbi.12438

Paper Glycoengineering of Antibodies for Modulating Functions

Wang, Lai‐Xi; Tong, Xin; Li, Chao et al. · 2019 · Annual Review of Biochemistry · DOI

Full title: Glycoengineering of Antibodies for Modulating Functions

Authors: Wang, Lai‐Xi; Tong, Xin; Li, Chao; Giddens, John P.; Li, Tiezheng

Year: 2019

Venue: Annual Review of Biochemistry

DOI: https://doi.org/10.1146/annurev-biochem-062917-012911

Paper Aggregates, Crystals, Gels, and Amyloids: Intracellular and Extracellular Phenotypes at the Crossroads of Immunoglobulin Physicochemical Property and Cell Physiology

Hasegawa, Haruki · 2013 · International Journal of Cell Biology · DOI

Full title: Aggregates, Crystals, Gels, and Amyloids: Intracellular and Extracellular Phenotypes at the Crossroads of Immunoglobulin Physicochemical Property and Cell Physiology

Authors: Hasegawa, Haruki

Year: 2013

Venue: International Journal of Cell Biology

DOI: https://doi.org/10.1155/2013/604867

Paper Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications

Zhong, Xiaotian; Wright, Jill F. · 2013 · International Journal of Cell Biology · DOI

Full title: Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications

Authors: Zhong, Xiaotian; Wright, Jill F.

Year: 2013

Venue: International Journal of Cell Biology

DOI: https://doi.org/10.1155/2013/273086

Paper Early Implementation of QbD in Biopharmaceutical Development: A Practical Example

Zurdo, Jesús; Arnell, Andreas; Obrezanova, Olga et al. · 2015 · BioMed Research International · DOI

Full title: Early Implementation of QbD in Biopharmaceutical Development: A Practical Example

Authors: Zurdo, Jesús; Arnell, Andreas; Obrezanova, Olga; Smith, Noel; Cuesta, Ramón Gómez de la; Gallagher, Thomas R. A.; Michael, Rebecca; Stallwood, Yvette; Ekblad, Caroline; Abrahmsén, Lars; Höidén‐Guthenberg, Ingmarie

Year: 2015

Venue: BioMed Research International

DOI: https://doi.org/10.1155/2015/605427

Paper Biopharmaceutical Manufacturing: Historical Perspectives and Future Directions

Szkodny, Alana C.; Lee, Kelvin H. · 2022 · Annual Review of Chemical and Biomolecular Engineering · DOI

Full title: Biopharmaceutical Manufacturing: Historical Perspectives and Future Directions

Authors: Szkodny, Alana C.; Lee, Kelvin H.

Year: 2022

Venue: Annual Review of Chemical and Biomolecular Engineering

DOI: https://doi.org/10.1146/annurev-chembioeng-092220-125832

Paper Abstract 6742: High-affinity human IgG1 antibody against GUCY2C for ADC development: Identification, characterization, and efficacy

Yunxia Zheng; Xiafen Wu; Junxiang Jia et al. · 2025 · Cancer Research · DOI

Full title: Abstract 6742: High-affinity human IgG1 antibody against GUCY2C for ADC development: Identification, characterization, and efficacy

Authors: Yunxia Zheng; Xiafen Wu; Junxiang Jia; Huihui Guo; Xiangfei Kong; Gengxiang Zhao; Yuanyuan Huang; Hangbo Ye; Xiaolei Liu; Yi Luo; Xiaoqiang Xie; Xia Zhou; Lu Bai; Wenjun Li; Binbin Chen; Qingliang Yang; R. Zhao

Year: 2025

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2025-6742

Paper The EF‐1α promoter maintains high‐level transgene expression from episomal vectors in transfected CHO‐K1 cells

Wang, Xiao-Yin; Xu, Zhong-Jie; Tian, Zheng‐Wei et al. · 2017 · Journal of Cellular and Molecular Medicine · DOI

Full title: The EF‐1α promoter maintains high‐level transgene expression from episomal vectors in transfected CHO‐K1 cells

Authors: Wang, Xiao-Yin; Xu, Zhong-Jie; Tian, Zheng‐Wei; Zhang, Xi; Xu, Danhua; Li, Qin; Zhang, Junhe; Wang, Tianyun

Year: 2017

Venue: Journal of Cellular and Molecular Medicine

DOI: https://doi.org/10.1111/jcmm.13216

Paper Immunoassays for Affinity, Avidity and Competition: Methods to Evaluate Monoclonal (and Polyclonal) Antibodies Useful Assays in Development of New Antibodies, Better Understanding of Commercial Antibodies: Their Usefulness in Specific Aims of Research [SOP]

A. Antes · 2016 · DOI

Full title: Immunoassays for Affinity, Avidity and Competition: Methods to Evaluate Monoclonal (and Polyclonal) Antibodies Useful Assays in Development of New Antibodies, Better Understanding of Commercial Antibodies: Their Usefulness in Specific Aims of Research [SOP]

Authors: A. Antes

Year: 2016

DOI: https://doi.org/10.13052/ijts2246-8765.2016.001

Paper The Inhibition Site on Myelin-Associated Glycoprotein Is within Ig-Domain 5 and Is Distinct from the Sialic Acid Binding Site

Cao, Zixuan; Qiu, Jin; Domeniconi, Marco et al. · 2007 · Journal of Neuroscience · DOI

Full title: The Inhibition Site on Myelin-Associated Glycoprotein Is within Ig-Domain 5 and Is Distinct from the Sialic Acid Binding Site

Authors: Cao, Zixuan; Qiu, Jin; Domeniconi, Marco; Hou, Jianwei; Bryson, J. Barney; Mellado, Wilfredo; Filbin, Marie T.

Year: 2007

Venue: Journal of Neuroscience

DOI: https://doi.org/10.1523/jneurosci.2404-07.2007

Paper Development of transfection and high-producer screening protocols for the CHOK1SV cell system

M. Celina de la Cruz Edmonds; M. Tellers; Christine Chan et al. · 2006 · Molecular Biotechnology · DOI

Full title: Development of transfection and high-producer screening protocols for the CHOK1SV cell system

Authors: M. Celina de la Cruz Edmonds; M. Tellers; Christine Chan; P. Salmon; D. Robinson; J. Markusen

Year: 2006

Venue: Molecular Biotechnology

DOI: https://doi.org/10.1385/mb:34:2:179

Paper High-yield production of recombinant antibody fragments in HEK-293 cells using sodium butyrate.

J. Grünberg; K. Knogler; R. Waibel et al. · 2003 · BioTechniques · DOI

Full title: High-yield production of recombinant antibody fragments in HEK-293 cells using sodium butyrate.

Authors: J. Grünberg; K. Knogler; R. Waibel; I. Novak‐Hofer

Year: 2003

Venue: BioTechniques

DOI: https://doi.org/10.2144/03345st02

Paper Production systems for recombinant antibodies

Schirrmann, Thomas · 2008 · Frontiers in bioscience · DOI

Full title: Production systems for recombinant antibodies

Authors: Schirrmann, Thomas

Year: 2008

Venue: Frontiers in bioscience

DOI: https://doi.org/10.2741/3024

Paper WITHDRAWN

Sietaram, Devi; Kotidis, Pavlos; Rowland‐Jones, Ruth C. et al. · 2024 · DOI

Full title: WITHDRAWN

Authors: Sietaram, Devi; Kotidis, Pavlos; Rowland‐Jones, Ruth C.; Finka, Gary; Lapkin, Alexei A.

Year: 2024

DOI: https://doi.org/10.26434/chemrxiv-2024-26vzd

Paper Directed evolution methods for overcoming trade‐offs between protein activity and stability

Stimple, Samuel D.; Smith, Matthew D.; Tessier, Peter M. · 2019 · AIChE Journal · DOI

Full title: Directed evolution methods for overcoming trade‐offs between protein activity and stability

Authors: Stimple, Samuel D.; Smith, Matthew D.; Tessier, Peter M.

Year: 2019

Venue: AIChE Journal

DOI: https://doi.org/10.1002/aic.16814

Paper Label‐free live cell imaging by Confocal Raman Microscopy identifies CHO host and producer cell lines

Mateu, Batirtze Prats; Harreither, Eva; Schosserer, Markus et al. · 2016 · Biotechnology Journal · DOI

Full title: Label‐free live cell imaging by Confocal Raman Microscopy identifies CHO host and producer cell lines

Authors: Mateu, Batirtze Prats; Harreither, Eva; Schosserer, Markus; Puxbaum, Verena; Gludovacz, Elisabeth; Borth, Nicole; Gierlinger, Notburga; Grillari, Johannes

Year: 2016

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.201600037

Paper Predictive glycoengineering of biosimilars using a Markov chain glycosylation model

Spahn, Philipp N.; Hansen, Anders Holmgaard; Kol, Stefan et al. · 2016 · Biotechnology Journal · DOI

Full title: Predictive glycoengineering of biosimilars using a Markov chain glycosylation model

Authors: Spahn, Philipp N.; Hansen, Anders Holmgaard; Kol, Stefan; Voldborg, Björn G.; Lewis, Nathan E.

Year: 2016

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.201600489

Paper Enhanced Genome Editing Tools For Multi‐Gene Deletion Knock‐Out Approaches Using Paired CRISPR sgRNAs in CHO Cells

Schmieder, Valerie; Bydlinski, Nina; Strasser, Richard et al. · 2017 · Biotechnology Journal · DOI

Full title: Enhanced Genome Editing Tools For Multi‐Gene Deletion Knock‐Out Approaches Using Paired CRISPR sgRNAs in CHO Cells

Authors: Schmieder, Valerie; Bydlinski, Nina; Strasser, Richard; Baumann, Martina; Kildegaard, Helene Faustrup; Jadhav, Vaibhav; Borth, Nicole

Year: 2017

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.201700211

Paper Pichia pastoris secretes recombinant proteins less efficiently than Chinese hamster ovary cells but allows higher space‐time yields for less complex proteins

Maccani, Andreas; Landes, Nils; Stadlmayr, Gerhard et al. · 2014 · Biotechnology Journal · DOI

Full title: Pichia pastoris secretes recombinant proteins less efficiently than Chinese hamster ovary cells but allows higher space‐time yields for less complex proteins

Authors: Maccani, Andreas; Landes, Nils; Stadlmayr, Gerhard; Maresch, Daniel; Leitner, Christian; Maurer, Michael; Gasser, Brigitte; Ernst, Wolfgang; Kunert, Renate; Mattanovich, Diethard

Year: 2014

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.201300305

Paper Defining process design space for monoclonal antibody cell culture.

Abu-Absi, Susan Fugett; Yang, LiYing; Thompson, Patrick et al. · 2010 · Biotechnology and bioengineering · DOI

Full title: Defining process design space for monoclonal antibody cell culture.

Authors: Abu-Absi, Susan Fugett; Yang, LiYing; Thompson, Patrick; Jiang, Canping; Kandula, Sunitha; Schilling, Bernhard; Shukla, Abhinav A

Year: 2010

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.22764

Paper Use of the chicken lysozyme 5′ matrix attachment region to generate high producer CHO cell lines

Girod, Pierre‐Alain; Zahn‐Zabal, Monique; Mermod, Nicolas · 2005 · Biotechnology and Bioengineering · DOI

Full title: Use of the chicken lysozyme 5′ matrix attachment region to generate high producer CHO cell lines

Authors: Girod, Pierre‐Alain; Zahn‐Zabal, Monique; Mermod, Nicolas

Year: 2005

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.20563

Paper Leveraging Transfection Dose Streamlines the Establishment of a Chinese Hamster Ovary Cell Targeted Integration System

Tao Sun; Xin Zhou; Yu Zhang et al. · 2025 · Biotechnology Journal · DOI

Full title: Leveraging Transfection Dose Streamlines the Establishment of a Chinese Hamster Ovary Cell Targeted Integration System

Authors: Tao Sun; Xin Zhou; Yu Zhang; Nan Yan; Ding Huang; Kee Wee Tan; Sam Zhang; Hang Zhou; Fei Chen; Xiaoyue Chen

Year: 2025

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.70165

Paper A study of monoclonal antibody‐producing CHO cell lines: What makes a stable high producer?

Chusainow, Janet; Yang, Yuansheng; Yeo, Jessna H. M. et al. · 2008 · Biotechnology and Bioengineering · DOI

Full title: A study of monoclonal antibody‐producing CHO cell lines: What makes a stable high producer?

Authors: Chusainow, Janet; Yang, Yuansheng; Yeo, Jessna H. M.; Toh, Poh Choo; Asvadi, Parisa; Wong, Niki S.C.; Yap, Miranda G.S.

Year: 2008

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.22158

Paper Evaluation of “Difficult‐to‐Express” Monoclonal Antibodies in a CHO‐Based Hybrid Site‐Specific Integration System Under Industrially Relevant Conditions

Szkodny, Alana C.; Lee, Kelvin H. · 2025 · Biotechnology Journal · DOI

Full title: Evaluation of “Difficult‐to‐Express” Monoclonal Antibodies in a CHO‐Based Hybrid Site‐Specific Integration System Under Industrially Relevant Conditions

Authors: Szkodny, Alana C.; Lee, Kelvin H.

Year: 2025

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.70102

Paper Duplication of a chromosome 2 segment in production CHO cell lines correlates with age‐related growth improvement

Wei Wei; Laura Zielewicz; Lin Zhang · 2024 · Biotechnology Journal · DOI

Full title: Duplication of a chromosome 2 segment in production CHO cell lines correlates with age‐related growth improvement

Authors: Wei Wei; Laura Zielewicz; Lin Zhang

Year: 2024

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.202300407

Paper Bioprocessing of Recombinant CHO-K1, CHO-DG44, and CHO-S: CHO Expression Hosts Favor Either mAb Production or Biomass Synthesis

Reinhart, David; Damjanovic, Lukas; Kaisermayer, Christian et al. · 2018 · Biotechnology Journal · DOI

Full title: Bioprocessing of Recombinant CHO-K1, CHO-DG44, and CHO-S: CHO Expression Hosts Favor Either mAb Production or Biomass Synthesis

Authors: Reinhart, David; Damjanovic, Lukas; Kaisermayer, Christian; Sommeregger, Wolfgang; Gili, Andreas; Gasselhuber, Bernhard; Castan, Andreas; Mayrhofer, Patrick; Grünwald‐Gruber, Clemens; Kunert, Renate

Year: 2018

Venue: Biotechnology Journal

DOI: https://doi.org/10.1002/biot.201700686

Paper Engineering mammalian cell factories for improved recombinant monoclonal antibody production: lessons from nature?

Dinnis, Diane M.; James, David C. · 2005 · Biotechnology and Bioengineering · DOI

Full title: Engineering mammalian cell factories for improved recombinant monoclonal antibody production: lessons from nature?

Authors: Dinnis, Diane M.; James, David C.

Year: 2005

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.20499

Paper Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells

Berger, Audrey; Fourn, Valérie Le; Masternak, Jacqueline et al. · 2020 · Biotechnology and Bioengineering · DOI

Full title: Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells

Authors: Berger, Audrey; Fourn, Valérie Le; Masternak, Jacqueline; Regamey, Alexandre; Bodenmann, Iris; Girod, Pierre‐Alain; Mermod, Nicolas

Year: 2020

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27274

Paper Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time

Feichtinger, Julia; Hernández, Inmaculada; Fischer, Christoph et al. · 2016 · Biotechnology and Bioengineering · DOI

Full title: Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time

Authors: Feichtinger, Julia; Hernández, Inmaculada; Fischer, Christoph; Hanscho, Michael; Auer, Norbert; Hackl, Matthias; Jadhav, Vaibhav; Baumann, Martina; Krempl, Peter M.; Schmidl, Christian; Farlik, Matthias; Schuster, Michael; Merkel, Angelika; Sommer, Andreas; Heath, Simon; Rico, Daniel; Bock, Christoph; Thallinger, Gerhard; Borth, Nicole

Year: 2016

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.25990

Paper Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring

Jorgolli, Marsela; Nevill, Tanner; Winters, Aaron et al. · 2019 · Biotechnology and Bioengineering · DOI

Full title: Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring

Authors: Jorgolli, Marsela; Nevill, Tanner; Winters, Aaron; Chen, Irwin; Chong, Su Kong; Lin, Fen‐Fen; Mock, Marissa; Chen, Ching; Le, Kim; Tan, Christopher; Jess, Philip; Han, Xu; Hamburger, Agi; Stevens, Jennitte; Munro, Trent P.; Wu, Ming C.; Tagari, Philip; Miranda, Les P.

Year: 2019

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27024

Paper Rapid whole monoclonal antibody analysis by mass spectrometry: An ultra scale-down study of the effect of harvesting by centrifugation on the post-translational modification profile.

Reid, C Q; Tait, A; Baldascini, H et al. · 2010 · Biotechnology and bioengineering · DOI

Full title: Rapid whole monoclonal antibody analysis by mass spectrometry: An ultra scale-down study of the effect of harvesting by centrifugation on the post-translational modification profile.

Authors: Reid, C Q; Tait, A; Baldascini, H; Mohindra, A; Racher, A; Bilsborough, S; Smales, C M; Hoare, M

Year: 2010

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.22790

Paper Modulation and modeling of monoclonal antibody N‐linked glycosylation in mammalian cell perfusion reactors

Daniel J. Karst; Ernesto Scibona; E. Serra et al. · 2017 · Biotechnology and Bioengineering · DOI

Full title: Modulation and modeling of monoclonal antibody N‐linked glycosylation in mammalian cell perfusion reactors

Authors: Daniel J. Karst; Ernesto Scibona; E. Serra; Jean-Marc Bielser; J. Souquet; Matthieu Stettler; H. Broly; M. Šoóš; M. Morbidelli; T. Villiger

Year: 2017

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.26315

Paper Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells

Chevallier, Valentine; Andersen, Mikael Rørdam; Malphettes, Laetitia · 2019 · Biotechnology and Bioengineering · DOI

Full title: Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells

Authors: Chevallier, Valentine; Andersen, Mikael Rørdam; Malphettes, Laetitia

Year: 2019

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27247

Paper Self‐Driving Development of Perfusion Processes for Monoclonal Antibody Production

Claudio Müller; Thomas Vuillemin; Chethana Janardhana Gadiyar et al. · 2025 · bioRxiv · DOI

Full title: Self‐Driving Development of Perfusion Processes for Monoclonal Antibody Production

Authors: Claudio Müller; Thomas Vuillemin; Chethana Janardhana Gadiyar; Jean-Marc Bielser; J. Souquet; Alessandro Fagnani; M. Sokolov; Moritz von Stosch; F. Feidl; A. Butté; M. N. Cruz Bournazou

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1002/bit.70093

Paper Antibody expression stability in CHO clonally derived cell lines and their subclones: Role of methylation in phenotypic and epigenetic heterogeneity

Patel, Neha A.; Anderson, Colin R.; Terkildsen, Sarah E. et al. · 2018 · Biotechnology Progress · DOI

Full title: Antibody expression stability in CHO clonally derived cell lines and their subclones: Role of methylation in phenotypic and epigenetic heterogeneity

Authors: Patel, Neha A.; Anderson, Colin R.; Terkildsen, Sarah E.; Davis, Ray C.; Pack, Laura; Bhargava, Swapnil; Clarke, Howard R. G.

Year: 2018

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2655

Paper Assurance of monoclonality in one round of cloning through cell sorting for single cell deposition coupled with high resolution cell imaging

Evans, Krista; Albanetti, Thomas; Venkat, Raghavan et al. · 2015 · Biotechnology Progress · DOI

Full title: Assurance of monoclonality in one round of cloning through cell sorting for single cell deposition coupled with high resolution cell imaging

Authors: Evans, Krista; Albanetti, Thomas; Venkat, Raghavan; Schoner, Ronald G.; Savery, James; Miró-Quesada, Guillermo; Rajan, Bhargavi; Groves, Christopher J.

Year: 2015

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2145

Paper Insertion of core CpG island element into human CMV promoter for enhancing recombinant protein expression stability in CHO cells

Mariati; Yeo, Jessna H. M.; Koh, Esther Y. C. et al. · 2014 · Biotechnology Progress · DOI

Full title: Insertion of core CpG island element into human CMV promoter for enhancing recombinant protein expression stability in CHO cells

Authors: Mariati; Yeo, Jessna H. M.; Koh, Esther Y. C.; Ho, Steven C. L.; Yang, Yuansheng

Year: 2014

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.1919

Paper Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production

Henry, Matthew; MacDonald, M. A.; Orellana, Camila A. et al. · 2020 · Biotechnology and Bioengineering · DOI

Full title: Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production

Authors: Henry, Matthew; MacDonald, M. A.; Orellana, Camila A.; Gray, Peter P.; Gillard, Marianne; Baker, Kym; Nielsen, Lars K.; Marcellin, Esteban; Mahler, Stephen M.; Martínez, Verónica S.

Year: 2020

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27269

Paper Production and scale‐up of a monoclonal antibody against 17‐hydroxyprogesterone

G. K. Chua; B. Abdul-Rahman; Y. Chisti · 2013 · Biotechnology progress (Print) · DOI

Full title: Production and scale‐up of a monoclonal antibody against 17‐hydroxyprogesterone

Authors: G. K. Chua; B. Abdul-Rahman; Y. Chisti

Year: 2013

Venue: Biotechnology progress (Print)

DOI: https://doi.org/10.1002/btpr.1656

Paper Accelerating and de‐risking CMC development with transposon‐derived manufacturing cell lines

Rajendran, Sowmya; Balasubramanian, Sowmya; Webster, Lynn et al. · 2021 · Biotechnology and Bioengineering · DOI

Full title: Accelerating and de‐risking CMC development with transposon‐derived manufacturing cell lines

Authors: Rajendran, Sowmya; Balasubramanian, Sowmya; Webster, Lynn; Lee, Maggie; Vavilala, Divya Teja; Kulikov, N.V.; Choi, Jessica; Tang, Calvin; Hunter, Molly; Wang, Rebecca; Kaur, Harpreet; Karunakaran, Surya; Sitaraman, Varsha; Minshull, Jeremy; Boldog, Ferenc

Year: 2021

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.27742

Paper Accelerating patient access to novel biologics using stable pool‐derived product for non‐clinical studies and single clone‐derived product for clinical studies

Munro, Trent P.; Le, Kim; Lê, Hương Giang et al. · 2017 · Biotechnology Progress · DOI

Full title: Accelerating patient access to novel biologics using stable pool‐derived product for non‐clinical studies and single clone‐derived product for clinical studies

Authors: Munro, Trent P.; Le, Kim; Lê, Hương Giang; Zhang, Lı; Stevens, Jennitte; Soice, Neil; Benchaar, Sabrina A.; Hong, Robert W.; Goudar, Chetan T.

Year: 2017

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2572

Paper Traces matter: Targeted optimization of monoclonal antibody N‐glycosylation based on/by implementing automated high‐throughput trace element screening

Sven Markert; S. Torkler; Katharina F. Hohmann et al. · 2020 · Biotechnology progress (Print) · DOI

Full title: Traces matter: Targeted optimization of monoclonal antibody N‐glycosylation based on/by implementing automated high‐throughput trace element screening

Authors: Sven Markert; S. Torkler; Katharina F. Hohmann; O. Popp

Year: 2020

Venue: Biotechnology progress (Print)

DOI: https://doi.org/10.1002/btpr.3042

Paper Scale-down model qualification of ambr® 250 high-throughput mini-bioreactor system for two commercial-scale mAb processes.

Manahan, Matthew; Nelson, Michael; Cacciatore, Jonathan J et al. · 2019 · Biotechnology progress · DOI

Full title: Scale-down model qualification of ambr® 250 high-throughput mini-bioreactor system for two commercial-scale mAb processes.

Authors: Manahan, Matthew; Nelson, Michael; Cacciatore, Jonathan J; Weng, Jessica; Xu, Sen; Pollard, Jennifer

Year: 2019

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2870

Paper Evolving trends in mAb production processes

Shukla, Abhinav; Wolfe, Leslie S.; Mostafa, Sigma S. et al. · 2017 · Bioengineering & Translational Medicine · DOI

Full title: Evolving trends in mAb production processes

Authors: Shukla, Abhinav; Wolfe, Leslie S.; Mostafa, Sigma S.; Norman, Carnley

Year: 2017

Venue: Bioengineering & Translational Medicine

DOI: https://doi.org/10.1002/btm2.10061

Paper Quick generation of R aman spectroscopy based in‐process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture

Berry, Brandon; Dobrowsky, Terrence M.; Timson, Rebecca C. et al. · 2015 · Biotechnology Progress · DOI

Full title: Quick generation of R aman spectroscopy based in‐process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture

Authors: Berry, Brandon; Dobrowsky, Terrence M.; Timson, Rebecca C.; Kshirsagar, Rashmi; Ryll, Thomas; Wiltberger, Kelly

Year: 2015

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2205

Paper N‐linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG

Berkel, Patrick H.C. van; Gerritsen, Jolanda; Perdok, Gerrard J. et al. · 2009 · Biotechnology Progress · DOI

Full title: N‐linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG

Authors: Berkel, Patrick H.C. van; Gerritsen, Jolanda; Perdok, Gerrard J.; Valbjørn, Jesper; Vink, Tom; Winkel, Jan G. J. van de; Parren, Paul W.H.I.

Year: 2009

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.92

Paper Characterization of phenotypic and genotypic diversity in subclones derived from a clonal cell line

Tharmalingam, Tharmala; Barkhordarian, Hedieh; Tejeda, Nicole et al. · 2018 · Biotechnology Progress · DOI

Full title: Characterization of phenotypic and genotypic diversity in subclones derived from a clonal cell line

Authors: Tharmalingam, Tharmala; Barkhordarian, Hedieh; Tejeda, Nicole; Daris, Kristi; Yaghmour, Sam; Yam, Pheng; Lu, Fang; Goudar, Chetan T.; Munro, Trent P.; Stevens, Jennitte

Year: 2018

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.2666

Paper CHO cells adapted to hypothermic growth produce high yields of recombinant β‐interferon

Sunley, Kevin; Tharmalingam, Tharmala; Butler, Michael · 2008 · Biotechnology Progress · DOI

Full title: CHO cells adapted to hypothermic growth produce high yields of recombinant β‐interferon

Authors: Sunley, Kevin; Tharmalingam, Tharmala; Butler, Michael

Year: 2008

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.9

Paper Preclinical development of a molecular clamp‐stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

Watterson, Daniel; Wijesundara, Danushka K.; Modhiran, Naphak et al. · 2021 · Clinical & Translational Immunology · DOI

Full title: Preclinical development of a molecular clamp‐stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

Authors: Watterson, Daniel; Wijesundara, Danushka K.; Modhiran, Naphak; Mordant, Francesca L.; Li, Zheyi; Avumegah, Michael S.; McMillan, Christopher L. D.; Lackenby, Julia; Guilfoyle, Kate; Amerongen, Geert van; Stittelaar, Koert J.; Cheung, Stacey T. M.; Bibby, Summa; Daleris, Mallory; Hoger, Kym; Gillard, Marianne; Radunz, Eve; Jones, Martina L.; Hughes, Karen; Hughes, Benjamin; Goh, Justin B.; Edwards, David; Scoble, Judith A.; Pearce, Lesley A.; Kowalczyk, Lukasz; Phan, Tram; La, Mylinh; Lu, Louis; Pham, Tam; Zhou, Qi; Brockman, David A.; Morgan, Sherry J.; Lau, Cora; Tran, Mai H.; Tapley, Peter; Villalón‐Letelier, Fernando; Barnes, James; Young, Andrew; Jaberolansar, Noushin; Scott, Connor A. P.; Isaacs, Ariel; Amarilla, Alberto A.; Khromykh, Alexander A.; Brand, Judith MA van den; Reading, Patrick C.; Ranasinghe, Charani; Subbarao, Kanta; Munro, Trent P.; Young, Paul R.; Chappell, Keith J.

Year: 2021

Venue: Clinical & Translational Immunology

DOI: https://doi.org/10.1002/cti2.1269

Paper Automation and miniaturization: enabling tools for fast, high‐throughput process development in integrated continuous biomanufacturing

Silva, Tiago Castanheira; Eppink, Michel H. M.; Ottens, Marcel · 2021 · Journal of Chemical Technology & Biotechnology · DOI

Full title: Automation and miniaturization: enabling tools for fast, high‐throughput process development in integrated continuous biomanufacturing

Authors: Silva, Tiago Castanheira; Eppink, Michel H. M.; Ottens, Marcel

Year: 2021

Venue: Journal of Chemical Technology & Biotechnology

DOI: https://doi.org/10.1002/jctb.6792

Paper Application of a quality by design approach to the cell culture process of monoclonal antibody production, resulting in the establishment of a design space.

Nagashima, Hiroaki; Watari, Akiko; Shinoda, Yasuharu et al. · 2013 · Journal of pharmaceutical sciences · DOI

Full title: Application of a quality by design approach to the cell culture process of monoclonal antibody production, resulting in the establishment of a design space.

Authors: Nagashima, Hiroaki; Watari, Akiko; Shinoda, Yasuharu; Okamoto, Hiroshi; Takuma, Shinya

Year: 2013

Venue: Journal of pharmaceutical sciences

DOI: https://doi.org/10.1002/jps.23744

Paper Over‐expression of secreted proteins from mammalian cell lines

Dalton, Annamarie C.; Barton, William A. · 2014 · Protein Science · DOI

Full title: Over‐expression of secreted proteins from mammalian cell lines

Authors: Dalton, Annamarie C.; Barton, William A.

Year: 2014

Venue: Protein Science

DOI: https://doi.org/10.1002/pro.2439

Paper Genome Engineering of Hybridomas to Generate Stable Cell Lines for Antibody Expression.

Cristina Parola; Derek M. Mason; A. Zingg et al. · 2018 · Methods in molecular biology · DOI

Full title: Genome Engineering of Hybridomas to Generate Stable Cell Lines for Antibody Expression.

Authors: Cristina Parola; Derek M. Mason; A. Zingg; D. Neumeier; S. Reddy

Year: 2018

Venue: Methods in molecular biology

DOI: https://doi.org/10.1007/978-1-4939-8730-6_7

Paper FLUIDOT: A Modular Microfluidic Platform for Single‐Cell Study and Retrieval, with Applications in Drug Tolerance Screening and Antibody Mining

Jolien Breukers; Karen Ven; Caroline Struyfs et al. · 2023 · Small Methods · DOI

Full title: FLUIDOT: A Modular Microfluidic Platform for Single‐Cell Study and Retrieval, with Applications in Drug Tolerance Screening and Antibody Mining

Authors: Jolien Breukers; Karen Ven; Caroline Struyfs; Louanne Ampofo; Iene Rutten; M. Imbrechts; Francesca Pollet; Julie Van Lent; Winnie Kerstens; Sam Noppen; D. Schols; P. De Munter; H. Thibaut; K. Vanhoorelbeke; D. Spasić; Paul Declerck; B. Cammue; N. Geukens; K. Thevissen; J. Lammertyn

Year: 2023

Venue: Small Methods

DOI: https://doi.org/10.1002/smtd.202201477

Paper An IRES-Mediated Tricistronic Vector for Efficient Generation of Stable, High-Level Monoclonal Antibody Producing CHO DG44 Cell Lines

Yeo, Jessna H. M.; Mariati; Yang, Yuansheng · 2018 · Methods in molecular biology · DOI

Full title: An IRES-Mediated Tricistronic Vector for Efficient Generation of Stable, High-Level Monoclonal Antibody Producing CHO DG44 Cell Lines

Authors: Yeo, Jessna H. M.; Mariati; Yang, Yuansheng

Year: 2018

Venue: Methods in molecular biology

DOI: https://doi.org/10.1007/978-1-4939-8648-4_17

Paper Fast quantitative determination of monoclonal antibody in infusion bags using protein A nano liquid chromatography

C. André; Y. Guillaume · 2024 · Separation Science Plus · DOI

Full title: Fast quantitative determination of monoclonal antibody in infusion bags using protein A nano liquid chromatography

Authors: C. André; Y. Guillaume

Year: 2024

Venue: Separation Science Plus

DOI: https://doi.org/10.1002/sscp.202400050

Paper Animal‐cell culture media: History, characteristics, and current issues

Yao, Tatsuma; Asayama, Yuta · 2017 · Reproductive Medicine and Biology · DOI

Full title: Animal‐cell culture media: History, characteristics, and current issues

Authors: Yao, Tatsuma; Asayama, Yuta

Year: 2017

Venue: Reproductive Medicine and Biology

DOI: https://doi.org/10.1002/rmb2.12024

Paper Screening and subcloning of high producer transfectomas using semisolid media and automated colony picker.

S. Dharshanan; C. S. Hung · 2014 · Methods in molecular biology · DOI

Full title: Screening and subcloning of high producer transfectomas using semisolid media and automated colony picker.

Authors: S. Dharshanan; C. S. Hung

Year: 2014

Venue: Methods in molecular biology

DOI: https://doi.org/10.1007/978-1-62703-992-5_7

Paper Rapid construction of transgene-amplified CHO cell lines by cell cycle checkpoint engineering

K. Lee; Masayoshi Onitsuka; K. Honda et al. · 2013 · Applied Microbiology and Biotechnology · DOI

Full title: Rapid construction of transgene-amplified CHO cell lines by cell cycle checkpoint engineering

Authors: K. Lee; Masayoshi Onitsuka; K. Honda; H. Ohtake; T. Omasa

Year: 2013

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-013-4923-9

Paper Multiple reaction monitoring targeted LC-MS analysis of potential cell death marker proteins for increased bioprocess control.

Albrecht, Simone; Kaisermayer, Christian; Reinhart, David et al. · 2018 · Analytical and bioanalytical chemistry · DOI

Full title: Multiple reaction monitoring targeted LC-MS analysis of potential cell death marker proteins for increased bioprocess control.

Authors: Albrecht, Simone; Kaisermayer, Christian; Reinhart, David; Ambrose, Monica; Kunert, Renate; Lindeberg, Anna; Bones, Jonathan

Year: 2018

Venue: Analytical and bioanalytical chemistry

DOI: https://doi.org/10.1007/s00216-018-1029-3

Paper Methods for production of monoclonal antibodies with specificity for human lung cancer cells

J. Minna; F. Cuttitta; S. Rosen et al. · 1981 · In Vitro · DOI

Full title: Methods for production of monoclonal antibodies with specificity for human lung cancer cells

Authors: J. Minna; F. Cuttitta; S. Rosen; P. Bunn; D. Carney; A. Gazdar; S. Krasnow

Year: 1981

Venue: In Vitro

DOI: https://doi.org/10.1007/bf02618603

Paper Current state and recent advances in biopharmaceutical production in Escherichia coli, yeasts and mammalian cells

Berlec, Aleš; Štrukelj, Borut · 2013 · Journal of Industrial Microbiology & Biotechnology · DOI

Full title: Current state and recent advances in biopharmaceutical production in Escherichia coli, yeasts and mammalian cells

Authors: Berlec, Aleš; Štrukelj, Borut

Year: 2013

Venue: Journal of Industrial Microbiology & Biotechnology

DOI: https://doi.org/10.1007/s10295-013-1235-0

Paper Using cell engineering and omic tools for the improvement of cell culture processes

Kuystermans, Darrin; Krampe, Britta; Swiderek, Halina et al. · 2007 · Cytotechnology · DOI

Full title: Using cell engineering and omic tools for the improvement of cell culture processes

Authors: Kuystermans, Darrin; Krampe, Britta; Swiderek, Halina; Al‐Rubeai, Mohamed

Year: 2007

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-007-9055-6

Paper Establishment of a semi-continuous scale-down clone screening model for intensified perfusion culture

Tao Sun; Yu Zhang; Hengrui Liang et al. · 2024 · Biotechnology Letters · DOI

Full title: Establishment of a semi-continuous scale-down clone screening model for intensified perfusion culture

Authors: Tao Sun; Yu Zhang; Hengrui Liang; Wenjing Fang; Zichen Qian; Kee Wee Tan; Junjie Li; Xiang Zheng; Mingyue Fang; Hang Zhou; Weichang Zhou; Sam Zhang

Year: 2024

Venue: Biotechnology Letters

DOI: https://doi.org/10.1007/s10529-024-03512-0

Paper Repeated integration of antibody genes into a pre-selected chromosomal locus of CHO cells using an accumulative site-specific gene integration system

Kawabe, Yoshinori; Makitsubo, Hirokatsu; Kameyama, Yujiro et al. · 2011 · Cytotechnology · DOI

Full title: Repeated integration of antibody genes into a pre-selected chromosomal locus of CHO cells using an accumulative site-specific gene integration system

Authors: Kawabe, Yoshinori; Makitsubo, Hirokatsu; Kameyama, Yujiro; Huang, ShuoHao; Itô, Akira; Kamihira, Masamichi

Year: 2011

Venue: Cytotechnology

DOI: https://doi.org/10.1007/s10616-011-9397-y

Paper From Efficiency to Yield: Exploring Recent Advances in CHO Cell Line Development for Monoclonal Antibodies

Sarmishta Majumdar; Ranjeet Desai; Aakarsh Hans et al. · 2024 · Molecular Biotechnology · DOI

Full title: From Efficiency to Yield: Exploring Recent Advances in CHO Cell Line Development for Monoclonal Antibodies

Authors: Sarmishta Majumdar; Ranjeet Desai; Aakarsh Hans; P. Dandekar; R. Jain

Year: 2024

Venue: Molecular Biotechnology

DOI: https://doi.org/10.1007/s12033-024-01060-6

Paper Characterization of a monoclonal antibody cell culture production process using a quality by design approach.

Horvath, Brian; Mun, Melissa; Laird, Michael W · 2010 · Molecular biotechnology · DOI

Full title: Characterization of a monoclonal antibody cell culture production process using a quality by design approach.

Authors: Horvath, Brian; Mun, Melissa; Laird, Michael W

Year: 2010

Venue: Molecular biotechnology

DOI: https://doi.org/10.1007/s12033-010-9267-4

Paper Molecular and functional analysis of monoclonal antibodies in support of biologics development

Wang, Xin; An, Zhiqiang; Luo, Wenxin et al. · 2017 · Protein & Cell · DOI

Full title: Molecular and functional analysis of monoclonal antibodies in support of biologics development

Authors: Wang, Xin; An, Zhiqiang; Luo, Wenxin; Xia, Ningshao; Zhao, Qinjian

Year: 2017

Venue: Protein & Cell

DOI: https://doi.org/10.1007/s13238-017-0447-x

Paper Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy

Mimura, Yusuke; Katoh, Toshihiko; Saldova, Radka et al. · 2017 · Protein & Cell · DOI

Full title: Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy

Authors: Mimura, Yusuke; Katoh, Toshihiko; Saldova, Radka; O’Flaherty, Róisín; Izumi, Tomonori; Mimura‐Kimura, Yuka; Utsunomiya, Toshiaki; Mizukami, Yoichi; Yamamoto, Kenji; Matsumoto, Tsuneo; Rudd, Pauline M.

Year: 2017

Venue: Protein & Cell

DOI: https://doi.org/10.1007/s13238-017-0433-3

Paper Engineering Translation in Mammalian Cell Factories to Increase Protein Yield: The Unexpected Use of Long Non-Coding SINEUP RNAs

Zucchelli, S.; Patrucco, Laura; Persichetti, Francesca et al. · 2016 · Computational and Structural Biotechnology Journal · DOI

Full title: Engineering Translation in Mammalian Cell Factories to Increase Protein Yield: The Unexpected Use of Long Non-Coding SINEUP RNAs

Authors: Zucchelli, S.; Patrucco, Laura; Persichetti, Francesca; Gustincich, Stefano; Cotella, Diego

Year: 2016

Venue: Computational and Structural Biotechnology Journal

DOI: https://doi.org/10.1016/j.csbj.2016.10.004

Paper Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing

O’Flaherty, Róisín; Bergin, Adam; Flampouri, Evangelia et al. · 2020 · Biotechnology Advances · DOI

Full title: Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing

Authors: O’Flaherty, Róisín; Bergin, Adam; Flampouri, Evangelia; Mota, Letícia Martins; Obaidi, Ismael; Quigley, Andrew; Xie, Yongjing; Butler, Michael

Year: 2020

Venue: Biotechnology Advances

DOI: https://doi.org/10.1016/j.biotechadv.2020.107552

Paper Stability of single copy transgene expression in CHOK1 cells is affected by histone modifications but not by DNA methylation

Spencer, Shawal; Gugliotta, Agustina; Koenitzer, Jennifer et al. · 2014 · Journal of Biotechnology · DOI

Full title: Stability of single copy transgene expression in CHOK1 cells is affected by histone modifications but not by DNA methylation

Authors: Spencer, Shawal; Gugliotta, Agustina; Koenitzer, Jennifer; Häuser, H.; Wirth, Dagmar

Year: 2014

Venue: Journal of Biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2014.12.009

Paper Glycosylation of biosimilars: Recent advances in analytical characterization and clinical implications

Duivelshof, Bastiaan L.; Jiskoot, Wim; Beck, Alain et al. · 2019 · Analytica Chimica Acta · DOI

Full title: Glycosylation of biosimilars: Recent advances in analytical characterization and clinical implications

Authors: Duivelshof, Bastiaan L.; Jiskoot, Wim; Beck, Alain; Veuthey, Jean‐Luc; Guillarme, Davy; D’Atri, Valentina

Year: 2019

Venue: Analytica Chimica Acta

DOI: https://doi.org/10.1016/j.aca.2019.08.044

Paper Genetic glycoengineering in mammalian cells

Narimatsu, Yoshiki; Büll, Christian; Chen, Yen‐Hsi et al. · 2021 · Journal of Biological Chemistry · DOI

Full title: Genetic glycoengineering in mammalian cells

Authors: Narimatsu, Yoshiki; Büll, Christian; Chen, Yen‐Hsi; Wandall, Hans H.; Yang, Zhang; Clausen, Henrik

Year: 2021

Venue: Journal of Biological Chemistry

DOI: https://doi.org/10.1016/j.jbc.2021.100448

Paper A robust scale-down model development and process characterization for monoclonal antibody biomanufacturing using multivariate data analysis.

Han, Sung-Hyuk; Park, Seo-Young; Cha, Hyun-Myoung et al. · 2025 · Journal of biotechnology · DOI

Full title: A robust scale-down model development and process characterization for monoclonal antibody biomanufacturing using multivariate data analysis.

Authors: Han, Sung-Hyuk; Park, Seo-Young; Cha, Hyun-Myoung; Lee, Kwang-Bae; Lim, Jin-Hyuk; Lee, Dong-Yup

Year: 2025

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2025.02.007

Paper Investigating the metabolic load of monoclonal antibody production conveyed to an inducible CHO cell line using a transfer-rate online monitoring system.

Reyes, Sebastian-Juan; Lemire, Lucas; Durocher, Yves et al. · 2025 · Journal of biotechnology · DOI

Full title: Investigating the metabolic load of monoclonal antibody production conveyed to an inducible CHO cell line using a transfer-rate online monitoring system.

Authors: Reyes, Sebastian-Juan; Lemire, Lucas; Durocher, Yves; Voyer, Robert; Henry, Olivier; Pham, Phuong Lan

Year: 2025

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2025.01.008

Paper Beyond tyrosine feeding: A novel fed-batch cultivation strategy based on tyrosine metabolic engineering in recombinant CHO cells.

Cao, Lei; Zhao, Liang; Ye, Qian et al. · 2026 · Journal of biotechnology · DOI

Full title: Beyond tyrosine feeding: A novel fed-batch cultivation strategy based on tyrosine metabolic engineering in recombinant CHO cells.

Authors: Cao, Lei; Zhao, Liang; Ye, Qian; Tan, Wen-Song

Year: 2026

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2025.10.003

Paper A rapid method for simultaneous evaluation of free light chain content and aggregate content in culture media of Chinese hamster ovary cells expressing monoclonal antibodies for cell line screening.

Yoichi Ishii; M. Tsukahara; K. Wakamatsu · 2016 · Journal of Bioscience and Bioengineering · DOI

Full title: A rapid method for simultaneous evaluation of free light chain content and aggregate content in culture media of Chinese hamster ovary cells expressing monoclonal antibodies for cell line screening.

Authors: Yoichi Ishii; M. Tsukahara; K. Wakamatsu

Year: 2016

Venue: Journal of Bioscience and Bioengineering

DOI: https://doi.org/10.1016/j.jbiosc.2015.08.002

Paper Beyond viability: Advancing CHO cell culture process strategies to modulate host cell protein levels

Sahoo, Ansuman; Devenney, Kyle; Nicolas, Marcus-Allen et al. · 2024 · New Biotechnology · DOI

Full title: Beyond viability: Advancing CHO cell culture process strategies to modulate host cell protein levels

Authors: Sahoo, Ansuman; Devenney, Kyle; Nicolas, Marcus-Allen; Zill, Nicholas; Gupta, Balrina; Madabhushi, Sri Ranganayaki

Year: 2024

Venue: New Biotechnology

DOI: https://doi.org/10.1016/j.nbt.2024.10.003

Paper Mobile Affinity Selection Chromatography Analysis of Therapeutic Monoclonal Antibodies

Meena L Narsimhan; Jinhee Kim; Nathan A Morris et al. · 2023 · Analytical Chemistry · DOI

Full title: Mobile Affinity Selection Chromatography Analysis of Therapeutic Monoclonal Antibodies

Authors: Meena L Narsimhan; Jinhee Kim; Nathan A Morris; Mary A Bower; Harsha P Gunawardena; Eric Bowen; Fred E Regnier

Year: 2023

Venue: Analytical Chemistry

DOI: https://doi.org/10.1021/acs.analchem.3c02180

Paper Hemin-DNA Switch-Assisted Microfluidic Chemiluminescence Immunoimaging for Rapid and Quantitative Screening of Specific Hybridomas.

Wencheng Xiao; Hang Ao; Nilin Wu et al. · 2026 · Analytical Chemistry · DOI

Full title: Hemin-DNA Switch-Assisted Microfluidic Chemiluminescence Immunoimaging for Rapid and Quantitative Screening of Specific Hybridomas.

Authors: Wencheng Xiao; Hang Ao; Nilin Wu; Jun Sun; Wenrui Hu; Yunlong Chen; Jie Wu; Huangxian Ju

Year: 2026

Venue: Analytical Chemistry

DOI: https://doi.org/10.1021/acs.analchem.5c07461

Paper Optimized Split Zeocin Selection System Enhances Monoclonal Antibody Productivity and Reduces High Mannose Levels in CHO Cells.

Shen, Yang; Liu, Jinpin; Liu, Tongxin et al. · 2025 · ACS synthetic biology · DOI

Full title: Optimized Split Zeocin Selection System Enhances Monoclonal Antibody Productivity and Reduces High Mannose Levels in CHO Cells.

Authors: Shen, Yang; Liu, Jinpin; Liu, Tongxin; Gao, Rong; Lian, Dujuan; Yang, Shuli; Feng, Quan; Huang, Ding; Zhang, Yu; Chen, Xiaoyue; Zhou, Hang; Liao, Shanhui; Sun, Tao

Year: 2025

Venue: ACS synthetic biology

DOI: https://doi.org/10.1021/acssynbio.5c00533

Paper Rapid Quantification of Monoclonal Antibody Titer in Cell Culture Harvests by Antibody-Induced Z-ELP-E2 Nanoparticle Cross-Linking.

A. Swartz; Wilfred Chen · 2018 · Analytical Chemistry · DOI

Full title: Rapid Quantification of Monoclonal Antibody Titer in Cell Culture Harvests by Antibody-Induced Z-ELP-E2 Nanoparticle Cross-Linking.

Authors: A. Swartz; Wilfred Chen

Year: 2018

Venue: Analytical Chemistry

DOI: https://doi.org/10.1021/acs.analchem.8b04083

Paper Estimating Absolute Protein–Protein Binding Free Energies by a Super Learner Model

E. J. F. Chaves; João Sartori; Whendel M Santos et al. · 2025 · Journal of Chemical Information and Modeling · DOI

Full title: Estimating Absolute Protein–Protein Binding Free Energies by a Super Learner Model

Authors: E. J. F. Chaves; João Sartori; Whendel M Santos; Carlos H B Cruz; Emmanuel N Mhrous; Manassés F Nacimento-Filho; M. Ferraz; Roberto D. Lins

Year: 2025

Venue: Journal of Chemical Information and Modeling

DOI: https://doi.org/10.1021/acs.jcim.4c01641

Paper Regulated overexpression of the survival factor bcl-2 in CHO cells increases viable cell density in batch culture and decreases DNA release in extended fixed-bed cultivation

Fussenegger, Martin; Fassnacht, D.; Schwartz, Regine et al. · 2000 · Cytotechnology · DOI

Full title: Regulated overexpression of the survival factor bcl-2 in CHO cells increases viable cell density in batch culture and decreases DNA release in extended fixed-bed cultivation

Authors: Fussenegger, Martin; Fassnacht, D.; Schwartz, Regine; Zanghi, James A.; Graf, Michael; Bailey, James E.; Pörtner, Ralf

Year: 2000

Venue: Cytotechnology

DOI: https://doi.org/10.1023/a:1008168522385

Paper Automated High-Throughput Capillary Circular Dichroism and Intrinsic Fluorescence Spectroscopy for Rapid Determination of Protein Structure

Charles Moore-Kelly; J. Welsh; A. Rodger et al. · 2019 · Analytical Chemistry · DOI

Full title: Automated High-Throughput Capillary Circular Dichroism and Intrinsic Fluorescence Spectroscopy for Rapid Determination of Protein Structure

Authors: Charles Moore-Kelly; J. Welsh; A. Rodger; T. Dafforn; O. Thomas

Year: 2019

Venue: Analytical Chemistry

DOI: https://doi.org/10.1021/acs.analchem.9b03259

Paper The gel microdrop secretion assay: Identification of a low productivity subpopulation arising during the production of human antibody in CHO cells

Hammill, Linda; Welles, J L; Carson, Gerald · 2000 · Cytotechnology · DOI

Full title: The gel microdrop secretion assay: Identification of a low productivity subpopulation arising during the production of human antibody in CHO cells

Authors: Hammill, Linda; Welles, J L; Carson, Gerald

Year: 2000

Venue: Cytotechnology

DOI: https://doi.org/10.1023/a:1008186113245

Paper A single droplet dispensing system for high-throughput screening and reliable recovery of rare events.

Marian Weiss; Sadat Hasan; Robert Genth et al. · 2025 · Lab on a Chip · DOI

Full title: A single droplet dispensing system for high-throughput screening and reliable recovery of rare events.

Authors: Marian Weiss; Sadat Hasan; Robert Genth; Mohammad Mollah; Elea Robert; Alejandro Gil; Lars Hufnagel

Year: 2025

Venue: Lab on a Chip

DOI: https://doi.org/10.1039/d4lc00536h

Paper Simple piggyBac transposon-based mammalian cell expression system for inducible protein production

Li, Zhijie; Michael, Iacovos P.; Zhou, Dongxia et al. · 2013 · Proceedings of the National Academy of Sciences · DOI

Full title: Simple piggyBac transposon-based mammalian cell expression system for inducible protein production

Authors: Li, Zhijie; Michael, Iacovos P.; Zhou, Dongxia; Nagy, András; Rini, James M.

Year: 2013

Venue: Proceedings of the National Academy of Sciences

DOI: https://doi.org/10.1073/pnas.1218620110

Paper COMPREHENSIVE EVALUATION OF EXPRESSION PLATFORM: CHERRY PICKING THE ‘RIGHT’ TO ACCOMPLISH THE ‘BEST

S. Gaur; Kinjal Bhadresha; B. Patel et al. · 2020 · Towards Excellence · DOI

Full title: COMPREHENSIVE EVALUATION OF EXPRESSION PLATFORM: CHERRY PICKING THE ‘RIGHT’ TO ACCOMPLISH THE ‘BEST

Authors: S. Gaur; Kinjal Bhadresha; B. Patel; M. Saraf; R. Rawal

Year: 2020

Venue: Towards Excellence

DOI: https://doi.org/10.37867/te120516

Paper Recent Advances in the Development of Monoclonal Antibodies and Next-Generation Antibodies

Singh, Rohit; Chandley, Pankaj; Rohatgi, Soma · 2023 · ImmunoHorizons · DOI

Full title: Recent Advances in the Development of Monoclonal Antibodies and Next-Generation Antibodies

Authors: Singh, Rohit; Chandley, Pankaj; Rohatgi, Soma

Year: 2023

Venue: ImmunoHorizons

DOI: https://doi.org/10.4049/immunohorizons.2300102

Paper Microbubbles: A high-throughput platform for the sustained culture, characterization, and isolation of single cells based on morphology, cytokine production, and antibody secretion.

James Kobie; L. DeLouise; A. Scheinman · 2017 · Journal of Immunology · DOI

Full title: Microbubbles: A high-throughput platform for the sustained culture, characterization, and isolation of single cells based on morphology, cytokine production, and antibody secretion.

Authors: James Kobie; L. DeLouise; A. Scheinman

Year: 2017

Venue: Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.198.supp.81.1

Paper Recombinant Dimeric IgA Antibodies against the Epidermal Growth Factor Receptor Mediate Effective Tumor Cell Killing

Lohse, Stefan; Derer, Stefanie; Beyer, Thomas et al. · 2011 · The Journal of Immunology · DOI

Full title: Recombinant Dimeric IgA Antibodies against the Epidermal Growth Factor Receptor Mediate Effective Tumor Cell Killing

Authors: Lohse, Stefan; Derer, Stefanie; Beyer, Thomas; Klausz, Katja; Peipp, Matthias; Leusen, Jeanette H.W.; Winkel, Jan G. J. van de; Dechant, Michael; Valerius, Thomas

Year: 2011

Venue: The Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.1003082

Paper Development of autoimmune antibodies against human phospholipase A2 receptor and the application as diagnostic criteria for primary membranous nephropathy.

Shukun Wu; Yixing Zhai; Na Yang et al. · 2025 · Clinical Nephrology · DOI

Full title: Development of autoimmune antibodies against human phospholipase A2 receptor and the application as diagnostic criteria for primary membranous nephropathy.

Authors: Shukun Wu; Yixing Zhai; Na Yang; Zhou Zhou; Yingchun Huang; Li Yang; Bing Lai; Guisen Li

Year: 2025

Venue: Clinical Nephrology

DOI: https://doi.org/10.5414/cn111747

Paper Cell culture processes for monoclonal antibody production.

Li, Feng; Vijayasankaran, Natarajan; Shen, Amy Yijuan et al. · 2010 · mAbs · DOI

Full title: Cell culture processes for monoclonal antibody production.

Authors: Li, Feng; Vijayasankaran, Natarajan; Shen, Amy Yijuan; Kiss, Robert; Amanullah, Ashraf

Year: 2010

Venue: mAbs

DOI: https://doi.org/10.4161/mabs.2.5.12720

Paper Bioprocessing of mAb (Monoclonal Antibodies) using Chinese Hamster Ovary (CHO) Cells: A Review

Richelle Bertly Josefano; Aivyanca A; Charlivo Mikaichi Dungus et al. · 2023 · Indonesian Journal of Life Sciences · DOI

Full title: Bioprocessing of mAb (Monoclonal Antibodies) using Chinese Hamster Ovary (CHO) Cells: A Review

Authors: Richelle Bertly Josefano; Aivyanca A; Charlivo Mikaichi Dungus; Jason Jonathan Hamid; Katherine Katherine

Year: 2023

Venue: Indonesian Journal of Life Sciences

DOI: https://doi.org/10.54250/ijls.v5i01.162

Paper Control of Key Parameters in Developing Mammalian Production Clones

Kunert, Renate; Wolbank, Susanne; Chang, Martina et al. · 2004

Full title: Control of Key Parameters in Developing Mammalian Production Clones

Authors: Kunert, Renate; Wolbank, Susanne; Chang, Martina; Voglauer, Regina; Borth, Nicole; Katinger, Hermann

Year: 2004

Paper [Production of anti-recombinant human arrest defective 1 protein (hARD1) monoclonal antibodies for assaying human breast cancer tissues].

Min Yu; Zehua Wang; Junli Gong et al. · 2010 · Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Full title: [Production of anti-recombinant human arrest defective 1 protein (hARD1) monoclonal antibodies for assaying human breast cancer tissues].

Authors: Min Yu; Zehua Wang; Junli Gong; Mingxing Ma; Yang Jiao; Weiwei Huang; Q. Lü; Lin Li; Hui Yang; D. Tan

Year: 2010

Venue: Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Thesis Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

Fan, Y; Jimenez del Val, I; Muller, C et al. · 2015 · Imperial College London · DOI

Full title: Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

Authors: Fan, Y; Jimenez del Val, I; Muller, C; Sen, JW; Rasmussen, SK; Kontoravdi, C; Weilguny, D; Andersen, MR

Year: 2015

Venue: Imperial College London

DOI: http://onlinelibrary.wiley.com/doi/10.1002/bit.25450/abstract

Thesis Cascading effect in bioprocessing – the impact of mild hypothermia on CHO cell behavior and host cell protein composition

Goey, CH; Tsang, J; Bell, D et al. · 2017 · Imperial College London · DOI

Full title: Cascading effect in bioprocessing – the impact of mild hypothermia on CHO cell behavior and host cell protein composition

Authors: Goey, CH; Tsang, J; Bell, D; Kontoravdi, C

Year: 2017

Venue: Imperial College London

DOI: https://onlinelibrary.wiley.com/doi/epdf/10.1002/bit.26437

Thesis Model-based investigation of intracellular processes determining antibody Fc-glycosylation under mild hypothermia

Sou, SN; Jedrzejewski, PM; Lee, K et al. · 2016 · Imperial College London · DOI

Full title: Model-based investigation of intracellular processes determining antibody Fc-glycosylation under mild hypothermia

Authors: Sou, SN; Jedrzejewski, PM; Lee, K; Sellick, C; Polizzi, KM; Kontoravdi, C

Year: 2016

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/42617

Thesis Exploring cellular behaviour under transient gene expression and its impact on mAb productivity and Fc glycosylation

Sou, SN; Ken, L; Nayyar, K et al. · 2017 · Imperial College London · DOI

Full title: Exploring cellular behaviour under transient gene expression and its impact on mAb productivity and Fc glycosylation

Authors: Sou, SN; Ken, L; Nayyar, K; Polizzi, KM; Sellick, C; Kontoravdi, C

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/50815

Thesis Novel in vivo biosensors for monitoring of mammalian cell cultures

Goers, Lisa · 2017 · Imperial College London · DOI

Full title: Novel in vivo biosensors for monitoring of mammalian cell cultures

Authors: Goers, Lisa

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/44463

Thesis Constrained global sensitivity analysis for bioprocess design space identification

Kotidis, Pavlos; Demis, Panagiotis; Goey, Cher et al. · 2019 · Imperial College London · DOI

Full title: Constrained global sensitivity analysis for bioprocess design space identification

Authors: Kotidis, Pavlos; Demis, Panagiotis; Goey, Cher; Correa, Elisa; McIntosh, calum; Trepekli, Stefania; Shah, Nilay; Klymenko, Oleksiy; Kontoravdi, Kleio

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/66121

Thesis Computational tools for predicting and controlling the glycosylation of biopharmaceuticals

Kontoravdi, K; Jimenez Del Val, Ioscani · 2018 · Imperial College London · DOI

Full title: Computational tools for predicting and controlling the glycosylation of biopharmaceuticals

Authors: Kontoravdi, K; Jimenez Del Val, Ioscani

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/63978

Thesis Understanding the impact of bioprocess conditions on monoclonal antibody glycosylation in mammalian cell cultures through experimental and computational analyses

Sou, Si Nga · 2018 · Imperial College London · DOI

Full title: Understanding the impact of bioprocess conditions on monoclonal antibody glycosylation in mammalian cell cultures through experimental and computational analyses

Authors: Sou, Si Nga

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/58304

Thesis An integrated experimental and modelling approach for the study of apoptosis in GS-NS0 cell cultures

Usaku, Chonlatep · 2016 · Imperial College London · DOI

Full title: An integrated experimental and modelling approach for the study of apoptosis in GS-NS0 cell cultures

Authors: Usaku, Chonlatep

Year: 2016

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/31863

Thesis Mild hypothermic culture conditions impact residual host cell protein composition post-protein a chromatography

Goey, CH; Bell, David; Kontoravdi, K · 2018 · Imperial College London · DOI

Full title: Mild hypothermic culture conditions impact residual host cell protein composition post-protein a chromatography

Authors: Goey, CH; Bell, David; Kontoravdi, K

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/63191

Thesis A platform for the optimisation of metabolic pathways for glycosylation to achieve a narrow and targeted glycoform distribution

Jedrzejewski, Philip · 2017 · Imperial College London · DOI

Full title: A platform for the optimisation of metabolic pathways for glycosylation to achieve a narrow and targeted glycoform distribution

Authors: Jedrzejewski, Philip

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/53386

Thesis Towards controlling the glycoform: a model framework linking extracellular metabolites to antibody glycosylation

Jedrzejewski, PM; Jimenez del Val, I; Constantinou, A et al. · 2018 · Imperial College London · DOI

Full title: Towards controlling the glycoform: a model framework linking extracellular metabolites to antibody glycosylation

Authors: Jedrzejewski, PM; Jimenez del Val, I; Constantinou, A; Dell, A; Haslam, SM; Polizzi, KM; Kontoravdi, C

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/63403

Thesis Apoptosis: A mammalian cell bioprocessing perspective

Grilo, Antonio L; Mantalaris, A · 2019 · Imperial College London · DOI

Full title: Apoptosis: A mammalian cell bioprocessing perspective

Authors: Grilo, Antonio L; Mantalaris, A

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/67883

Thesis Glycoengineering Chinese hamster ovary cells: a short history

Donini, roberto; Haslam, stuart; Kontoravdi, Kleio · 2021 · Imperial College London · DOI

Full title: Glycoengineering Chinese hamster ovary cells: a short history

Authors: Donini, roberto; Haslam, stuart; Kontoravdi, Kleio

Year: 2021

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/87918

Thesis Strategic framework for parameterization of cell culture models

Kotidis, Pavlos; Kontoravdi, Cleo · 2019 · Imperial College London · DOI

Full title: Strategic framework for parameterization of cell culture models

Authors: Kotidis, Pavlos; Kontoravdi, Cleo

Year: 2019

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000464443100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Cascading effects in bioprocessing: the impact of cell culture environment on CHO cell behaviour and host cell protein species

Goey, Cher Hui · 2017 · Imperial College London · DOI

Full title: Cascading effects in bioprocessing: the impact of cell culture environment on CHO cell behaviour and host cell protein species

Authors: Goey, Cher Hui

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/52703

Thesis Model-based optimization of antibody galactosylation in CHO cell culture

Kotidis, Pavlos; Jedrzejewski, Philip; Sou, Si Nga et al. · 2019 · Imperial College London · DOI

Full title: Model-based optimization of antibody galactosylation in CHO cell culture

Authors: Kotidis, Pavlos; Jedrzejewski, Philip; Sou, Si Nga; Sellick, Christopher; Polizzi, Karen; Del Val, Ioscani Jimenez; Kontoravdi, Cleo

Year: 2019

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/30802295

Thesis Mathematical modelling and experimental validation for optimisation and control of mammalian cell culture systems

Quiroga Campano, Ana · 2019 · Imperial College London · DOI

Full title: Mathematical modelling and experimental validation for optimisation and control of mammalian cell culture systems

Authors: Quiroga Campano, Ana

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/68071

Thesis CHO cell cultures in shake flasks and bioreactors present different host cell protein profiles in the supernatant

Goey, CH; Bell, D; Kontoravdi, C · 2019 · Imperial College London · DOI

Full title: CHO cell cultures in shake flasks and bioreactors present different host cell protein profiles in the supernatant

Authors: Goey, CH; Bell, D; Kontoravdi, C

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/67420

Thesis Osmolality effects on CHO cell growth, cell volume and antibody productivity and glycosylation

Alhuthali, Sakhr; Kotidis, Pavlos; Kontoravdi, Kleio · 2021 · Imperial College London · DOI

Full title: Osmolality effects on CHO cell growth, cell volume and antibody productivity and glycosylation

Authors: Alhuthali, Sakhr; Kotidis, Pavlos; Kontoravdi, Kleio

Year: 2021

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/88797

Thesis Synergising stoichiometric modelling with artificial neural networks to predict antibody glycosylation patterns in Chinese hamster ovary cells

Antonakoudis, Athanasios; Strain, Benjamin; Barbosa, Rodrigo et al. · 2021 · Imperial College London · DOI

Full title: Synergising stoichiometric modelling with artificial neural networks to predict antibody glycosylation patterns in Chinese hamster ovary cells

Authors: Antonakoudis, Athanasios; Strain, Benjamin; Barbosa, Rodrigo; Jimenez del Val, Ioscani; Kontoravdi, Kleio

Year: 2021

Venue: Imperial College London

DOI: https://www.sciencedirect.com/science/article/pii/S0098135421002490?via%3Dihub

Thesis DigiGlyc: A hybrid tool for reactive scheduling in cell culture systems

Kotidis, Pavlos; Pappas, Iosif; Avraamidou, Styliana et al. · 2021 · Imperial College London · DOI

Full title: DigiGlyc: A hybrid tool for reactive scheduling in cell culture systems

Authors: Kotidis, Pavlos; Pappas, Iosif; Avraamidou, Styliana; Pistikopoulos, Efstratios N; Kontoravdi, Cleo; Papathanasiou, Maria M

Year: 2021

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000697031900010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Harnessing the potential of artificial neural networks for predicting protein glycosylation

Kotidis, P; Kontoravdi, Kleio · 2020 · Imperial College London · DOI

Full title: Harnessing the potential of artificial neural networks for predicting protein glycosylation

Authors: Kotidis, P; Kontoravdi, Kleio

Year: 2020

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/80115

Thesis Mathematical modelling for bioprocess understanding and optimisation

Alhuthali, Sakhr · 2020 · Imperial College London · DOI

Full title: Mathematical modelling for bioprocess understanding and optimisation

Authors: Alhuthali, Sakhr

Year: 2020

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/84849

Thesis Integrated multi-scale mathematical models for biologics process development

Martins de Jesus Lima Grilo, António Carlos · 2020 · Imperial College London · DOI

Full title: Integrated multi-scale mathematical models for biologics process development

Authors: Martins de Jesus Lima Grilo, António Carlos

Year: 2020

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/81634

Thesis Developing a lactate-inducible transgene expression system for use in Chinese hamster ovary cells

Motraghi, Charles · 2021 · Imperial College London · DOI

Full title: Developing a lactate-inducible transgene expression system for use in Chinese hamster ovary cells

Authors: Motraghi, Charles

Year: 2021

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/87120

Thesis Population balance modelling captures host cell protein dynamics in CHO cell cultures

Alhuthali, Sakhr; Kontoravdi, Cleo · 2022 · Imperial College London · DOI

Full title: Population balance modelling captures host cell protein dynamics in CHO cell cultures

Authors: Alhuthali, Sakhr; Kontoravdi, Cleo

Year: 2022

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/96277

Thesis Strategies to control therapeutic antibody glycosylation during bioprocessing: synthesis and separation.

Edwards, Elizabeth; Livanos, Maria; Krueger, Anja et al. · 2022 · Imperial College London · DOI

Full title: Strategies to control therapeutic antibody glycosylation during bioprocessing: synthesis and separation.

Authors: Edwards, Elizabeth; Livanos, Maria; Krueger, Anja; Dell, Anne; Haslam, Stuart M; Mark Smales, C; Bracewell, Daniel G

Year: 2022

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/35182428

Thesis Engineering challenges in therapeutic protein product and process design

Papathanasiou, Maria M; Kontoravdi, Cleo · 2021 · Imperial College London · DOI

Full title: Engineering challenges in therapeutic protein product and process design

Authors: Papathanasiou, Maria M; Kontoravdi, Cleo

Year: 2021

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000544589400011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.

Kumpel, Belinda M; Saldova, Radka; Koeleman, Carolien A M et al. · 2020 · University of Cambridge · DOI

Full title: Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.

Authors: Kumpel, Belinda M; Saldova, Radka; Koeleman, Carolien A M; Abrahams, Jodie L; Ederveen, Agnes Hipgrave; Armour, Kathryn L; Olovnikova, Natalia I; Vidarsson, Gestur; Kapur, Rick; Rudd, Pauline M; Wuhrer, Manfred

Year: 2020

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/302986

Thesis Rapid antibody glycoengineering in Chinese hamster ovary cells.

Marbiah, Masue; Kotidis, Pavlos; Donini, Roberto et al. · 2022 · Imperial College London · DOI

Full title: Rapid antibody glycoengineering in Chinese hamster ovary cells.

Authors: Marbiah, Masue; Kotidis, Pavlos; Donini, Roberto; Gómez, Itzcóatl A; Jimenez Del Val, Ioscani; Haslam, Stuart M; Polizzi, Karen M; Kontoravdi, Cleo

Year: 2022

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/35723478

Thesis Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch

Gangadharan, Nishanthi · 2023 · University of Cambridge · DOI

Full title: Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch

Authors: Gangadharan, Nishanthi

Year: 2023

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/358135

Thesis Glycosylation Flux Analysis of Immunoglobulin G in Chinese Hamster Ovary Perfusion Cell Culture

Hutter, Sandro; Wolf, Moritz; Papili Gao, Nan et al. · 2018 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Glycosylation Flux Analysis of Immunoglobulin G in Chinese Hamster Ovary Perfusion Cell Culture

Authors: Hutter, Sandro; Wolf, Moritz; Papili Gao, Nan; Lepori, Dario; Schweigler, Thea; Morbidelli, Massimo; Gunawan, Rudiyanto

Year: 2018

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/294344

Thesis Bioprocess optimization under uncertainty using ensemble modeling

Liu, Yang; Gunawan, Rudiyanto · 2017 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Bioprocess optimization under uncertainty using ensemble modeling

Authors: Liu, Yang; Gunawan, Rudiyanto

Year: 2017

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/230667

Thesis Perfusion mammalian cell culture for recombinant protein manufacturing – A critical review

Bielser, Jean-Marc; Wolf, Moritz; Souquet, Jonathan et al. · 2018 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Perfusion mammalian cell culture for recombinant protein manufacturing – A critical review

Authors: Bielser, Jean-Marc; Wolf, Moritz; Souquet, Jonathan; Broly, Hervé; Morbidelli, Massimo

Year: 2018

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/268594

Thesis Scale-down modeling of CHO fed-batch processes for monoclonal antibody production

Sieck, Jochen Bastian · 2012 · ETH Zurich Research Collection · DOI

Full title: Scale-down modeling of CHO fed-batch processes for monoclonal antibody production

Authors: Sieck, Jochen Bastian

Year: 2012

Venue: ETH Zurich Research Collection

DOI: http://hdl.handle.net/20.500.11850/153701

Thesis From strain engineering to process development: monoclonal antibody production with an unnatural amino acid in Pichia pastoris

Tir, Nora; Heistinger, Lina; Grünwald-Gruber, Clemens et al. · 2022 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: From strain engineering to process development: monoclonal antibody production with an unnatural amino acid in Pichia pastoris

Authors: Tir, Nora; Heistinger, Lina; Grünwald-Gruber, Clemens; Jakob, Leo A.; Dickgiesser, Stephan; Rasche, Nicolas; Mattanovich, Diethard

Year: 2022

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/565141

Thesis CelloSelect – A synthetic cellobiose metabolic pathway for selection of stable transgenic CHO cell lines

Teixeira, Ana P.; Stücheli, Pascal; Ausländer, Simon et al. · 2022 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: CelloSelect – A synthetic cellobiose metabolic pathway for selection of stable transgenic CHO cell lines

Authors: Teixeira, Ana P.; Stücheli, Pascal; Ausländer, Simon; Ausländer, David; Schönenberger, Pascal; Hürlemann, Samuel; Fussenegger, Martin; id_orcid0000-0001-8545-667X

Year: 2022

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/526708

Thesis Estudi d'estratègies de cultiu per a cèl·lules animals, basades en eines d'instrumentació i control

Gámez Montoya, Xavier · 2011 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Estudi d'estratègies de cultiu per a cèl·lules animals, basades en eines d'instrumentació i control

Authors: Gámez Montoya, Xavier

Year: 2011

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://www.tdx.cat/TDX-0125102-110641

Thesis High-Yield Production of Extracellular Vesicle Subpopulations with Constant Quality Using Batch-Refeed Cultures

Paganini, Carolina; Boyce, Hannah; Libort, Gabriela et al. · 2023 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: High-Yield Production of Extracellular Vesicle Subpopulations with Constant Quality Using Batch-Refeed Cultures

Authors: Paganini, Carolina; Boyce, Hannah; Libort, Gabriela; Arosio, Paolo

Year: 2023

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/590829

Thesis Model-based analysis of N-glycosylation in Chinese hamster ovary cells

Krambeck, Frederick J.; Bennun, Sandra V; Andersen, Mikael Rørdam et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Model-based analysis of N-glycosylation in Chinese hamster ovary cells

Authors: Krambeck, Frederick J.; Bennun, Sandra V; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Betenbaugh, Michael J.

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b07b66c3-9b3c-42d5-8350-78cf6f0092cb

Thesis Early-Stage In Silico Flowsheet Analysis for a Monoclonal Antibody Platform

Kaiser, Johann; id_orcid 0000-0002-1383-6531; Babi, Deenesh K. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Early-Stage In Silico Flowsheet Analysis for a Monoclonal Antibody Platform

Authors: Kaiser, Johann; id_orcid 0000-0002-1383-6531; Babi, Deenesh K.; Pinelo, Manuel; id_orcid 0000-0002-3944-6144; Krühne, Ulrich; id_orcid 0000-0001-7774-7442

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c3fbbf6b-2d0e-43ac-9387-8537778ebc8f

Thesis CHO glyco-engineering using CRISPR/Cas9 multiplexing for protein production with homogeneous N-glycan profiles

Amann, Thomas; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787 et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: CHO glyco-engineering using CRISPR/Cas9 multiplexing for protein production with homogeneous N-glycan profiles

Authors: Amann, Thomas; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Pristovsek, Nusa; Singh, Ankita; Min Lee, Gyun; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c6d75303-ecfd-4e56-a505-e7c61e81da81

Thesis Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

Noh, Soo Min; Shin, Seunghyeon; Min Lee, Gyun · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

Authors: Noh, Soo Min; Shin, Seunghyeon; Min Lee, Gyun

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c3748c8e-d76f-40e3-8fcb-c291becc3057

Thesis MODEL COMPARISON TO DESCRIBE BHK-21 CELL GROWTH AND METABOLISM IN STIRRED TANK BIOREACTORS OPERATED IN BATCH MODE

Sartori, Roger [UNESP]; Leme, Jaci; Caricati, Celso Pereira et al. · 2019 · Universidade Estadual Paulista (UNESP) · DOI

Full title: MODEL COMPARISON TO DESCRIBE BHK-21 CELL GROWTH AND METABOLISM IN STIRRED TANK BIOREACTORS OPERATED IN BATCH MODE

Authors: Sartori, Roger [UNESP]; Leme, Jaci; Caricati, Celso Pereira; Tonso, Aldo; Fernandez Nunez, Eutimio Gustavo [UNESP]

Year: 2019

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1590/0104-6632.20180352s20160592

Thesis An Online Compendium of CHO RNA-Seq Data Allows Identification of CHO Cell Line-specific Transcriptomic Signatures

Singh, Ankita; Kildegaard, Helene F.; Andersen, Mikael R. et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: An Online Compendium of CHO RNA-Seq Data Allows Identification of CHO Cell Line-specific Transcriptomic Signatures

Authors: Singh, Ankita; Kildegaard, Helene F.; Andersen, Mikael R.; id_orcid 0000-0003-4794-6808

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bf556aa7-6180-46f6-8a4f-dd827e2311ac

Thesis Evaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration

Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Kumar Ganesan, Saravana et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Evaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration

Authors: Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Kumar Ganesan, Saravana; Martínez-Monje, Iván; Grav, Lise M.; id_orcid 0000-0001-8042-7108; Lavado-García, Jesús; Nielsen, Lars K.

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c72a6084-3783-4f79-b07b-6c0d4b2e6fdb

Thesis Chemical Inhibition of Autophagy:Examining its Potential to Increase the Specific Productivity of Recombinant CHO Cell Lines

Baek, Eric; Lin Kim, Che; Gyeom Kim, Mi et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Chemical Inhibition of Autophagy:Examining its Potential to Increase the Specific Productivity of Recombinant CHO Cell Lines

Authors: Baek, Eric; Lin Kim, Che; Gyeom Kim, Mi; Lee, Jae Seong; Min Lee, Gyun

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b8b4c661-28e5-45a2-8a60-42f9cdea3745

Thesis Method of designing carbohydrates

Lewis, Nathan; Chiang, Wan-Tien; Liang, Chenguang · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Method of designing carbohydrates

Authors: Lewis, Nathan; Chiang, Wan-Tien; Liang, Chenguang

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ba83157b-c8c3-43b6-8fd5-c238aa8df054

Thesis Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions

Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions

Authors: Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup; Min Lee, Gyun

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d8293414-1d83-4cde-bd35-d5339a98b4f4

Thesis Predictive glycoengineering of biosimilars using a Markov chain glycosylation model

Spahn, Philipp N.; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787 et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Predictive glycoengineering of biosimilars using a Markov chain glycosylation model

Authors: Spahn, Philipp N.; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Voldborg, Bjørn Gunnar; id_orcid 0000-0002-7005-1642; Lewis, Nathan E.

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c81572eb-3d8b-4c44-b92d-952116fe851f

Thesis Identifying Drivers of Downstream Yield Variability Using Integrated Process Models: An Application to API Manufacturing

Overgaard, Tobias; Bertran, Maria Ona; Jørgensen, John Bagterp et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Identifying Drivers of Downstream Yield Variability Using Integrated Process Models: An Application to API Manufacturing

Authors: Overgaard, Tobias; Bertran, Maria Ona; Jørgensen, John Bagterp; id_orcid 0000-0001-9799-2808; Nielsen, Bo Friis; id_orcid 0000-0001-9146-9733

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c4296fd2-3123-42e0-8e21-f09af0e5990b

Thesis Multiplex secretome engineering enhances recombinant protein production and purity

Kol, Stefan; Ley, Daniel; Wulff, Tune et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Multiplex secretome engineering enhances recombinant protein production and purity

Authors: Kol, Stefan; Ley, Daniel; Wulff, Tune; Decker, Marianne; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Schoffelen, Sanne; id_orcid 0000-0003-2664-8561; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Jensen, Tanja Lyholm; Gutierrez, Jahir M.; Chiang, Austin W. T.; Masson, Helen O.; Palsson, Bernhard O.; id_orcid 0000-0003-2357-6785; Voldborg, Bjørn Gunnar; id_orcid 0000-0002-7005-1642; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Kildegaard, Helene Faustrup; Min Lee, Gyun; Lewis, Nathan E.

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c440cd45-e242-4b63-9b03-861ba7d54bf2

Thesis Bioprocess for testing engineered cho cell lines using single-use bioreactors

Decker, Marianne · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Bioprocess for testing engineered cho cell lines using single-use bioreactors

Authors: Decker, Marianne

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/dc4a0b9d-3f6c-410b-97ef-d0ede37e6c36

Thesis Targeted gene integration for improved production of therapeutic proteins in CHO cells

Sergeeva, Daria · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Targeted gene integration for improved production of therapeutic proteins in CHO cells

Authors: Sergeeva, Daria

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e5d1f7f4-51e8-4ccc-989e-2d60bf1b29d7

Thesis Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells

Hefzi, Hooman; id_orcid 0009-0003-4067-6224; Martínez-Monge, Iván et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells

Authors: Hefzi, Hooman; id_orcid 0009-0003-4067-6224; Martínez-Monge, Iván; Marin de Mas, Igor; Cowie, Nicholas Luke; Toledo, Alejandro Gomez; Noh, Soo Min; Karottki, Karen Julie la Cour; Decker, Marianne; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Camacho-Zaragoza, Jose Manuel; Kol, Stefan; Schoffelen, Sanne; id_orcid 0000-0003-2664-8561; Pristovšek, Nuša; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Miguez, Antonio A.; Bjørn, Sara Petersen; id_orcid 0000-0003-3341-6160; Brøndum, Karen Kathrine; Javidi, Elham Maria; Jensen, Kristian Lund; Stangl, Laura; Kreidl, Emanuel; Kallehauge, Thomas Beuchert; Ley, Daniel; Ménard, Patrice; Petersen, Helle Munck; Sukhova, Zulfiya; Bauer, Anton; Casanova, Emilio; Barron, Niall; Malmström, Johan; Nielsen, Lars K.; Lee, Gyun Min; Kildegaard, Helene Faustrup; Voldborg, Bjørn G.; id_orcid 0000-0002-7005-1642; Lewis, Nathan E.

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c14c0655-7eef-4331-a9a9-fb44dd376e02

Thesis Multi-omic profiling of EPO-producing CHO cell panel reveals metabolic adaptation to heterologous protein production

Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Multi-omic profiling of EPO-producing CHO cell panel reveals metabolic adaptation to heterologous protein production

Authors: Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael; Magdenoska, Olivera; Nielsen, Kristian Fog; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d87f41ff-ed91-4f7b-bc8e-f9f6e581ebcb

Thesis Engineering death resistance in CHO cells for improved perfusion culture

MacDonald, Michael A.; Nöbel, Matthias; Martínez, Verónica S. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Engineering death resistance in CHO cells for improved perfusion culture

Authors: MacDonald, Michael A.; Nöbel, Matthias; Martínez, Verónica S.; Baker, Kym; Shave, Evan; Gray, Peter P.; Mahler, Stephen; Munro, Trent; Nielsen, Lars K.; Marcellin, Esteban

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ce202b32-0a67-4570-a87a-ab0849f12696

Thesis Knockout of sialidase and pro-apoptotic genes in Chinese hamster ovary cells enables the production of recombinant human erythropoietin in fed-batch cultures

Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Knockout of sialidase and pro-apoptotic genes in Chinese hamster ovary cells enables the production of recombinant human erythropoietin in fed-batch cultures

Authors: Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kildegaard, Helene Faustrup; Lee, Gyun Min

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c9ed1093-409a-45e5-9e27-a66fbd8ce161

Thesis Mitigating Clonal Variation in Recombinant Mammalian Cell Lines

Lee, Jae Seong; Kildegaard, Helene Faustrup; Lewis, Nathan E et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Mitigating Clonal Variation in Recombinant Mammalian Cell Lines

Authors: Lee, Jae Seong; Kildegaard, Helene Faustrup; Lewis, Nathan E; Min Lee, Gyun

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e6ffd8f9-bc7e-4842-a4c6-d073cdd1aba6

Thesis Improving culture performance and antibody production in CHO cell culture processes by reducing the Warburg effect

Buchsteiner, Maria; Quek, Lake-Ee; Gray, Peter et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Improving culture performance and antibody production in CHO cell culture processes by reducing the Warburg effect

Authors: Buchsteiner, Maria; Quek, Lake-Ee; Gray, Peter; Nielsen, Lars K.

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f0e67f85-4820-447f-988a-01acc4454c93

Thesis Expanding the CRISPR Toolbox for Chinese Hamster Ovary Cell Line Engineering

Julie la Cour Karottki, Karen · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Expanding the CRISPR Toolbox for Chinese Hamster Ovary Cell Line Engineering

Authors: Julie la Cour Karottki, Karen

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d08e2c40-059b-4d60-af81-5dcae6b7155e

Thesis Proteomic Analysis of Chinese Hamster Ovary Cells

Baycin-Hizal, Deniz; Tabb, David L.; Chaerkady, Raghothama et al. · 2012 · Technical University of Denmark (DTU) · DOI

Full title: Proteomic Analysis of Chinese Hamster Ovary Cells

Authors: Baycin-Hizal, Deniz; Tabb, David L.; Chaerkady, Raghothama; Chen, Lily; Lewis, Nathan; Nagarajan, Harish; Sarkaria, Vishaldeep; Kumar, Amit; Wolozny, Daniel; Colao, Joe; Jacobson, Elena; Tian, Yuan; O’Meally, Robert N.; Krag, Sharon S.; Cole, Robert N.; Palsson, Bernhard; id_orcid 0000-0003-2357-6785; Zhang, Hui; Betenbaugh, Michael

Year: 2012

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ce35867c-d9a3-4f8a-83d1-381c8096ef40

Thesis Network Reconstruction and In Silico Metabolic Model of Chinese Hamster Ovary cells

Calmels, Cyrielle · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Network Reconstruction and In Silico Metabolic Model of Chinese Hamster Ovary cells

Authors: Calmels, Cyrielle

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e8e79519-7089-44aa-9964-6700b9af9251

Thesis Customizing amino acid metabolism of Pichia pastoris for recombinant protein production

Rußmayer, Hannes; Buchetics, Markus; Mattanovich, Matthias et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Customizing amino acid metabolism of Pichia pastoris for recombinant protein production

Authors: Rußmayer, Hannes; Buchetics, Markus; Mattanovich, Matthias; Neubauer, Stefan; Steiger, Matthias; Graf, Alexandra B.; Koellensperger, Gunda; Hann, Stephan; Sauer, Michael; Gasser, Brigitte; Mattanovich, Diethard

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e65f1561-1cd7-495e-8db2-b64cc656c938

Thesis Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion

Ley, Daniel; Pereira, Sara; Pedersen, Lasse Ebdrup et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion

Authors: Ley, Daniel; Pereira, Sara; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Hefzi, Hooman; Davy, Anne Mathilde; Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Wulff, Tune; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e6e02b2a-1da9-46ca-ab3f-71e6a95e52f8

Thesis Systems Glycoengineering: Integrated Analyses of Glycomics, Transcriptomics and Phenotypic Data Reveal Complex Cellular Response to Glycoengineering in CHO Cells

Chiang, Wan-Tien; Gazestani, Vahid H.; Bao, Bokan et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Systems Glycoengineering: Integrated Analyses of Glycomics, Transcriptomics and Phenotypic Data Reveal Complex Cellular Response to Glycoengineering in CHO Cells

Authors: Chiang, Wan-Tien; Gazestani, Vahid H.; Bao, Bokan; Liang, Chenguang; Sorrention, James T.; Kellman, Benjamin P; Ménard, Patrice; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Sukhova, Zulfiya; Petersen Bjørn, Sara; id_orcid 0000-0003-3341-6160; Brøndum, Karen Kathrine; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Yang, Zhang; Joshi, Hiren; Clausen, Henrik; Voldborg, Bjørn Gunnar; id_orcid 0000-0002-7005-1642; Lewis, Nathan E.

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/efa2b2f2-9e12-42e0-8bdc-61da320e021d

Thesis Application of CRISPR/Cas9 Genome Editing to Improve Recombinant Protein Production in CHO Cells

Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Julie la Cour Karottki, Karen et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Application of CRISPR/Cas9 Genome Editing to Improve Recombinant Protein Production in CHO Cells

Authors: Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Julie la Cour Karottki, Karen; Lee, Jae Seong; Kildegaard, Helene Faustrup

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/fd4bf523-2939-4567-94bf-52951b06175f

Thesis Design of Optimal CHO Protein N-glycosylation Profiles

Amann, Thomas · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Design of Optimal CHO Protein N-glycosylation Profiles

Authors: Amann, Thomas

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f56793d2-957c-4049-bb8d-1cb2253f60a3

Thesis Proteomics in Cell Culture: From Genomics to Combined ‘Omics for Cell Line Engineering and Bioprocess Development

Heffner, Kelley; Kaas, Christian Schrøder; Kumar, Amit et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Proteomics in Cell Culture: From Genomics to Combined ‘Omics for Cell Line Engineering and Bioprocess Development

Authors: Heffner, Kelley; Kaas, Christian Schrøder; Kumar, Amit; Baycin-Hizal, Deniz; Betenbaugh, Michael

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f3008eb3-73ff-43ea-8c16-e730fc63ed76

Thesis Modeling apoptosis resistance in CHO cells with CRISPR-mediated knockouts of Bak1, Bax, and Bok

MacDonald, Michael A.; Barry, Craig; Groves, Teddy et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Modeling apoptosis resistance in CHO cells with CRISPR-mediated knockouts of Bak1, Bax, and Bok

Authors: MacDonald, Michael A.; Barry, Craig; Groves, Teddy; Martínez, Verónica S.; Gray, Peter P.; Baker, Kym; Shave, Evan; Mahler, Stephen; Munro, Trent; Marcellin, Esteban; Nielsen, Lars K.

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f471d371-7ef9-48ac-ad01-8f0de141966f

Thesis Exploring the diversity and productivity of clonal Chinese hamster ovary host cell lines derived from a non-clonal population

Jeavons, Andrew · 2016 · University of Manchester · DOI

Full title: Exploring the diversity and productivity of clonal Chinese hamster ovary host cell lines derived from a non-clonal population

Authors: Jeavons, Andrew

Year: 2016

Venue: University of Manchester

DOI: https://research.manchester.ac.uk/en/studentTheses/512a4667-4a93-40ea-9a81-6b5b961e10e9

Thesis Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells

Chevallier, Valentine; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808 et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells

Authors: Chevallier, Valentine; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Malphettes, Laetitia

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ff089eb9-bd04-4d58-a66a-ada79e4b6341

Thesis Optimizing the glycosylation of recombinant proteins

Rosenlöcher, Julia · 2016 · Freie Universität Berlin (Refubium) · DOI

Full title: Optimizing the glycosylation of recombinant proteins

Authors: Rosenlöcher, Julia

Year: 2016

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/4198

Thesis Investigation of the role of the mTORC1 signalling pathway in growth and productivity of industrially-relevant GS-CHO cells

Dadehbeigi, Nazanin · 2012 · University of Manchester · DOI

Full title: Investigation of the role of the mTORC1 signalling pathway in growth and productivity of industrially-relevant GS-CHO cells

Authors: Dadehbeigi, Nazanin

Year: 2012

Venue: University of Manchester

DOI: https://research.manchester.ac.uk/en/studentTheses/b7820f57-2023-4667-830d-53ce1fe7eb76

Thesis A Streamlined Multivariate Analysis Platform for Optimizing Mammalian Cell Culture and Biologics Production

Mingee, Andrew Nicholas · 2021 · Georgia Institute of Technology · DOI

Full title: A Streamlined Multivariate Analysis Platform for Optimizing Mammalian Cell Culture and Biologics Production

Authors: Mingee, Andrew Nicholas

Year: 2021

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/65145

Thesis DROSOPHILA S2 cell culture in a WAVE Bioreactor: potential for scaling up the production of the recombinant rabies virus glycoprotein

Decarli, Monize Caiado; Santos, Diogo Peres dos; Astray, Renato Mancini et al. · 2018 · Universidade Estadual Paulista (UNESP) · DOI

Full title: DROSOPHILA S2 cell culture in a WAVE Bioreactor: potential for scaling up the production of the recombinant rabies virus glycoprotein

Authors: Decarli, Monize Caiado; Santos, Diogo Peres dos; Astray, Renato Mancini; Ventini-Monteiro, Daniella Cristina; Calil Jorge, Soraia Attie; Correia, Daniela Matilde; Silva, Juliana de Sa da; Rocca, Mayra Pereira [UNESP]; Langoni, Helio [UNESP]; Menozzi, Benedito Donizete [UNESP]; Pereira, Carlos Augusto; Torres Suazo, Claudio Alberto

Year: 2018

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1007/s00253-018-8962-0

Thesis Amino acid metabolism during batch culture of a murine hybridoma, AFP- 27

Barford, John Patrick; Marquis, Christopher Peter; Harbour, Colin · 1996 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Amino acid metabolism during batch culture of a murine hybridoma, AFP- 27

Authors: Barford, John Patrick; Marquis, Christopher Peter; Harbour, Colin

Year: 1996

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68870

Thesis The Effect of Heterofunctional Microparticles on Identifying High Producing CHO cells

Aurelio, Caroline · 2022 · Georgia Institute of Technology · DOI

Full title: The Effect of Heterofunctional Microparticles on Identifying High Producing CHO cells

Authors: Aurelio, Caroline

Year: 2022

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/66272

Thesis The Dynamic Sampling Platform (DSP) for Real-time Bioreactor Monitoring

Chilmonczyk, Mason A. · 2021 · Georgia Institute of Technology · DOI

Full title: The Dynamic Sampling Platform (DSP) for Real-time Bioreactor Monitoring

Authors: Chilmonczyk, Mason A.

Year: 2021

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/64969

Thesis Effect of Feed Rate on Growth Rate and Antibody Production in the Fed-batch Culture of Murine Hybridoma Cells

Jang, JD; Barford, JP · 2000 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Effect of Feed Rate on Growth Rate and Antibody Production in the Fed-batch Culture of Murine Hybridoma Cells

Authors: Jang, JD; Barford, JP

Year: 2000

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-24332

Thesis Biosynthesis of protein products by animal cells. Are growth and non- growth associated concepts valid or useful?

Barford, John Patrick; Phillips, Peter J.; Marquis, Christopher Peter et al. · 1996 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Biosynthesis of protein products by animal cells. Are growth and non- growth associated concepts valid or useful?

Authors: Barford, John Patrick; Phillips, Peter J.; Marquis, Christopher Peter; Harbour, Colin

Year: 1996

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68868

Thesis Methods and strategies available for the process control and optimization of monoclonal antibody production

Barford, John Patrick; Fu Pengcheng, · 1994 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Methods and strategies available for the process control and optimization of monoclonal antibody production

Authors: Barford, John Patrick; Fu Pengcheng,

Year: 1994

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68893

Thesis An Unstructured Kinetic Model of Macromolecular Metabolism in Batch and Fed-batch Cultures of Hybridoma Cells Producing Monoclonal Antibody

Jang, DJ; Barford, JP · 2000 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: An Unstructured Kinetic Model of Macromolecular Metabolism in Batch and Fed-batch Cultures of Hybridoma Cells Producing Monoclonal Antibody

Authors: Jang, DJ; Barford, JP

Year: 2000

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-28049

Thesis Evaluation of the batch kinetics of the amino acid metabolism of a mouse hybridoma and human lymphoblastoid cell line using a pre-column FDNDEA derivitisation, HPLC technique

Marquis, Christopher Peter; Barford, John Patrick; Harbour, Colin et al. · 1996 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Evaluation of the batch kinetics of the amino acid metabolism of a mouse hybridoma and human lymphoblastoid cell line using a pre-column FDNDEA derivitisation, HPLC technique

Authors: Marquis, Christopher Peter; Barford, John Patrick; Harbour, Colin; Nobbs, Denis M.

Year: 1996

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68904

Thesis Carbohydrate and amino acid metabolism during batch culture of a human lymphoblastoid cell line, BTSN6

Barford, John Patrick; Marquis, Christopher Peter; Harbour, Colin et al. · 1996 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Carbohydrate and amino acid metabolism during batch culture of a human lymphoblastoid cell line, BTSN6

Authors: Barford, John Patrick; Marquis, Christopher Peter; Harbour, Colin; Fletcher, Anne

Year: 1996

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68873

Thesis An analysis of some batch and continuous kinetic data of specific monoclonal antibodt production from hybridomas

Barford, John Patrick; Phillips, Peter J.; Marquis, Christopher Peter et al. · 1991 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: An analysis of some batch and continuous kinetic data of specific monoclonal antibodt production from hybridomas

Authors: Barford, John Patrick; Phillips, Peter J.; Marquis, Christopher Peter; Harbour, Colin

Year: 1991

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68958

Thesis The use of biosensors in control of fed-batch processes - Opportunities and limitations

Renneberg, R.; Barford, JP; Tse, SMA · 1998 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: The use of biosensors in control of fed-batch processes - Opportunities and limitations

Authors: Renneberg, R.; Barford, JP; Tse, SMA

Year: 1998

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-44080

Thesis Simulation and dynamic optimisation of animal cell culture

Barford, John Patrick; Sanderson, Charles S.; Barton, Geoffrey W. · 1997 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Simulation and dynamic optimisation of animal cell culture

Authors: Barford, John Patrick; Sanderson, Charles S.; Barton, Geoffrey W.

Year: 1997

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68866

Thesis Optimisation of animal cell culture media using dynamic simulation

Barford, John Patrick; Sanderson, Charles S.; Barton, Geoffrey W. · 1995 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Optimisation of animal cell culture media using dynamic simulation

Authors: Barford, John Patrick; Sanderson, Charles S.; Barton, Geoffrey W.

Year: 1995

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68885

Thesis A comparison of different culture methods for hybridoma propagation and monoclonal antibody production

Barford, John Patrick; Marquis, Christopher Peter; Harbour, Colin et al. · 1990 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: A comparison of different culture methods for hybridoma propagation and monoclonal antibody production

Authors: Barford, John Patrick; Marquis, Christopher Peter; Harbour, Colin; Löw, K.S.

Year: 1990

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68971

Thesis CHOGlycoNET: comprehensive glycosylation reaction network for CHO cells

Kotidis, Pavlos; Donini, Roberto; Arnsdorf, Johnny et al. · 2023 · Imperial College London · DOI

Full title: CHOGlycoNET: comprehensive glycosylation reaction network for CHO cells

Authors: Kotidis, Pavlos; Donini, Roberto; Arnsdorf, Johnny; Hansen, Anders Holmgaard; Voldborg, Bjorn Gunnar Rude; Chiang, Austin WT; Haslam, Stuart M; Betenbaugh, Michael; del Val, Ioscani Jimenez; Lewis, Nathan E; Krambeck, Frederick; Kontoravdi, Cleo

Year: 2023

Venue: Imperial College London

DOI: https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000927440500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Genome-Based Metabolic Modelling of CHO Cells

Chen, Ning · 2013 · Imperial College London · DOI

Full title: Genome-Based Metabolic Modelling of CHO Cells

Authors: Chen, Ning

Year: 2013

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/11054

Thesis Enhanced understanding of protein glycosylation in CHO cells through computational tools and experimentation

Kotidis, Pavlos · 2022 · Imperial College London · DOI

Full title: Enhanced understanding of protein glycosylation in CHO cells through computational tools and experimentation

Authors: Kotidis, Pavlos

Year: 2022

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/100281

Thesis Towards advanced bioprocess optimization: a multiscale modelling approach

Monteiro, Mariana; Fadda, Sarah; Kontoravdi, Kleio · 2023 · Imperial College London · DOI

Full title: Towards advanced bioprocess optimization: a multiscale modelling approach

Authors: Monteiro, Mariana; Fadda, Sarah; Kontoravdi, Kleio

Year: 2023

Venue: Imperial College London

DOI: https://www.sciencedirect.com/science/article/pii/S2001037023002362

Thesis Utilising a genome scale metabolic model to design high-producing CHO cell lines through bi-level optimisation

Antonakoudis, Athanasios · 2024 · Imperial College London · DOI

Full title: Utilising a genome scale metabolic model to design high-producing CHO cell lines through bi-level optimisation

Authors: Antonakoudis, Athanasios

Year: 2024

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/110783

Thesis Systematic development of predictive mathematical models for animal cell cultures

Kontoravdi, Cleo; Pistikopoulos, Efstratios N; Mantalaris, Athanasios · 2014 · Imperial College London · DOI

Full title: Systematic development of predictive mathematical models for animal cell cultures

Authors: Kontoravdi, Cleo; Pistikopoulos, Efstratios N; Mantalaris, Athanasios

Year: 2014

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000279658700003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Effect of Chinese hamster ovary culture PH on sialylation and antibody productivity

McIntosh, Calum John · 2024 · Imperial College London · DOI

Full title: Effect of Chinese hamster ovary culture PH on sialylation and antibody productivity

Authors: McIntosh, Calum John

Year: 2024

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/110593

Thesis Development of hybrid platforms for antibody manufacturing optimisation

Barbosa, Rodrigo · 2024 · Imperial College London · DOI

Full title: Development of hybrid platforms for antibody manufacturing optimisation

Authors: Barbosa, Rodrigo

Year: 2024

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/110760

Thesis How reliable are Chinese hamster ovary (CHO) cell genome-scale metabolic models?

Strain, Benjamin; Morrissey, richard; Antonakoudis, Athanasios et al. · 2023 · Imperial College London · DOI

Full title: How reliable are Chinese hamster ovary (CHO) cell genome-scale metabolic models?

Authors: Strain, Benjamin; Morrissey, richard; Antonakoudis, Athanasios; Kontoravdi, Kleio

Year: 2023

Venue: Imperial College London

DOI: https://onlinelibrary.wiley.com/doi/full/10.1002/bit.28366

Thesis Glycoengineering and mass spectrometry for the improvement of biopharmaceuticals

Donini, Roberto · 2024 · Imperial College London · DOI

Full title: Glycoengineering and mass spectrometry for the improvement of biopharmaceuticals

Authors: Donini, Roberto

Year: 2024

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/111180

Thesis Assessment of the interactions between bioprocess conditions and protein glycosylation in antibody- producing mammalian cell cultures

Jimenez Del Val, Ioscani · 2014 · Imperial College London · DOI

Full title: Assessment of the interactions between bioprocess conditions and protein glycosylation in antibody- producing mammalian cell cultures

Authors: Jimenez Del Val, Ioscani

Year: 2014

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/15160

Thesis NEXT-FBA: a hybrid stoichiometric/data-driven approach to improve intracellular flux predictions

Morrissey, James; Barberi, Gianmarco; Strain, Benjamin et al. · 2025 · Imperial College London · DOI

Full title: NEXT-FBA: a hybrid stoichiometric/data-driven approach to improve intracellular flux predictions

Authors: Morrissey, James; Barberi, Gianmarco; Strain, Benjamin; Facco, Pierantonio; Kontoravdi, Cleo

Year: 2025

Venue: Imperial College London

DOI: https://hdl.handle.net/10044/1/118593

Thesis Simulation of animal cell metabolism

Barford, John Patrick; Phillips, Peter J.; Harbour, Colin · 1992 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Simulation of animal cell metabolism

Authors: Barford, John Patrick; Phillips, Peter J.; Harbour, Colin

Year: 1992

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68920

Thesis In Situ Monitoring of Intracellular Glucose and Glutamine in CHO Cell Culture

Behjousiar, A; Kontoravdi, C; Polizzi, KM · 2014 · Imperial College London · DOI

Full title: In Situ Monitoring of Intracellular Glucose and Glutamine in CHO Cell Culture

Authors: Behjousiar, A; Kontoravdi, C; Polizzi, KM

Year: 2014

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/14483

Thesis A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation

Jimenez del Val, I; Polizzi, K; Kontoravdi, C · 2016 · Imperial College London · DOI

Full title: A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation

Authors: Jimenez del Val, I; Polizzi, K; Kontoravdi, C

Year: 2016

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/33608

Thesis From titer to quality: exploring reinforcement learning for bioprocess control in silico

Monteiro, Mariana; Flevaris, Konstantinos; Kontoravdi, Cleo · 2025 · Imperial College London · DOI

Full title: From titer to quality: exploring reinforcement learning for bioprocess control in silico

Authors: Monteiro, Mariana; Flevaris, Konstantinos; Kontoravdi, Cleo

Year: 2025

Venue: Imperial College London

DOI: https://hdl.handle.net/10044/1/124760

Thesis In situ FRET Biosensors for the in vivo measurement of important metabolites during cell culture

Behjousiar, Alireza · 2015 · Imperial College London · DOI

Full title: In situ FRET Biosensors for the in vivo measurement of important metabolites during cell culture

Authors: Behjousiar, Alireza

Year: 2015

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/24852

Thesis Development and application of genome-scale models in chinese hamster ovary cell culture

Morrissey, Richard James · 2025 · Imperial College London · DOI

Full title: Development and application of genome-scale models in chinese hamster ovary cell culture

Authors: Morrissey, Richard James

Year: 2025

Venue: Imperial College London

DOI: https://hdl.handle.net/10044/1/122460

Thesis Towards continuous biomanufacturing a computational approach for the intensification of monoclonal antibody production

Papathanasiou, Maria · 2017 · Imperial College London · DOI

Full title: Towards continuous biomanufacturing a computational approach for the intensification of monoclonal antibody production

Authors: Papathanasiou, Maria

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/49449

Thesis In silico dynamic optimisation studies for batch/fed-batch mammalian cell suspension cultures producing biopharmaceuticals

Lam, Ming-Chi · 2017 · Imperial College London · DOI

Full title: In silico dynamic optimisation studies for batch/fed-batch mammalian cell suspension cultures producing biopharmaceuticals

Authors: Lam, Ming-Chi

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/45465

Thesis Amino acid metabolism in Chinese hamster ovary cell culture

Kyriakopoulos, Sarantos · 2015 · Imperial College London · DOI

Full title: Amino acid metabolism in Chinese hamster ovary cell culture

Authors: Kyriakopoulos, Sarantos

Year: 2015

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/25143

Thesis Improved bioprocess with CHO-hTSH cells on higher microcarrier concentration provides higher overall biomass and productivity for rhTSH

Pereira, Carlos Augusto · 2011 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Improved bioprocess with CHO-hTSH cells on higher microcarrier concentration provides higher overall biomass and productivity for rhTSH

Authors: Pereira, Carlos Augusto

Year: 2011

Venue: Universidade de São Paulo – USP Digital Library

DOI: http://www.springerlink.com/content/0273-2289/164/4/

Thesis The Engineering of Chinese Hamster Ovary Cells to Achieve More Efficient Gene Amplification for Improving Biopharmaceutical Development

Cacciatore, Jonathan Joseph · 2012 · Columbia University · DOI

Full title: The Engineering of Chinese Hamster Ovary Cells to Achieve More Efficient Gene Amplification for Improving Biopharmaceutical Development

Authors: Cacciatore, Jonathan Joseph

Year: 2012

Venue: Columbia University

DOI: https://doi.org/10.7916/D8DV1RZD

Thesis Desenvolvimento de bioprocessos com células S2 e CHO em biorreatores para produção de proteínas recombinantes

Pereira, Carlos Augusto · 2010 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Desenvolvimento de bioprocessos com células S2 e CHO em biorreatores para produção de proteínas recombinantes

Authors: Pereira, Carlos Augusto

Year: 2010

Venue: Universidade de São Paulo – USP Digital Library

DOI: 001835801

Thesis A Systematic Framework to Optimize and Control Monoclonal Antibody Manufacturing Process

Li, Ying Fei · 2018 · Columbia University · DOI

Full title: A Systematic Framework to Optimize and Control Monoclonal Antibody Manufacturing Process

Authors: Li, Ying Fei

Year: 2018

Venue: Columbia University

DOI: https://doi.org/10.7916/D8GX5TJP

Thesis Direct quality control of glycoengineered erythropoietin variants

Čaval, Tomislav; Tian, Weihua; Yang, Zhang et al. · 2018 · Utrecht University · DOI

Full title: Direct quality control of glycoengineered erythropoietin variants

Authors: Čaval, Tomislav; Tian, Weihua; Yang, Zhang; Clausen, Henrik; Heck, Albert J R

Year: 2018

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/368318

Thesis Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra

Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn et al. · 2021 · Utrecht University · DOI

Full title: Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra

Authors: Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn; Mastrobattista, Enrico; Yamabhai, Montarop

Year: 2021

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/418108

Thesis Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Zhang, Liang · 2020 · KTH Royal Institute of Technology · DOI

Full title: Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Authors: Zhang, Liang

Year: 2020

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-273343

Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn et al. · 2021 · Utrecht University · DOI

Authors: Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn; Mastrobattista, Enrico; Yamabhai, Montarop

Year: 2021

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/419433

Thesis Suitability of transiently expressed antibodies for clinical studies: product quality consistency at different production scales

Rodriguez-Conde, Sara; Inman, Sophie; Lindo, Viv et al. · 2022 · Utrecht University · DOI

Full title: Suitability of transiently expressed antibodies for clinical studies: product quality consistency at different production scales

Authors: Rodriguez-Conde, Sara; Inman, Sophie; Lindo, Viv; Amery, Leanne; Tang, Alison; Okorji-Obike, Uche; Du, Wenjuan; Bosch, Berend-Jan; Wichgers Schreur, Paul J; Kortekaas, Jeroen; Sola, Isabel; Enjuanes, Luis; Kerry, Laura; Mahal, Katharina; Hulley, Martyn; Daramola, Olalekan

Year: 2022

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/418557

Thesis Suitability of transiently expressed antibodies for clinical studies: product quality consistency at different production scales

Rodriguez-Conde, Sara; Inman, Sophie; Lindo, Viv et al. · 2022 · Utrecht University · DOI

Full title: Suitability of transiently expressed antibodies for clinical studies: product quality consistency at different production scales

Year: 2022

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/419893

Thesis N-linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG

van Berkel, P.H.C.; Gerritsen, J.; Perdok, G. et al. · 2009 · Utrecht University · DOI

Full title: N-linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG

Authors: van Berkel, P.H.C.; Gerritsen, J.; Perdok, G.; Valbjørn, J.; Vink, T.; van de Winkel, J.G.J.; Parren, P.W.H.I.

Year: 2009

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/42525

Thesis Changes in the Overall Extent of Protein Glycosylation by Chinese Hamster Ovary Cells Over the Course of Batch Culture

Yuk, Inn Huam Yvonne.; Wang, Daniel I.C. · 2003 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Changes in the Overall Extent of Protein Glycosylation by Chinese Hamster Ovary Cells Over the Course of Batch Culture

Authors: Yuk, Inn Huam Yvonne.; Wang, Daniel I.C.

Year: 2003

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/3776

Thesis Glycosylation by Chinese Hamster Ovary Cells in Dolichol Phosphate-Supplemented Cultures

Yuk, Inn Huam Yvonne.; Wang, Daniel I.C. · 2003 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Glycosylation by Chinese Hamster Ovary Cells in Dolichol Phosphate-Supplemented Cultures

Authors: Yuk, Inn Huam Yvonne.; Wang, Daniel I.C.

Year: 2003

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/3784

Thesis Characterization and improvement of interferon-[gamma] glycosylation in Chinese hamster ovary cell culture

Gu, Xuejun, 1970- · 2005 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Characterization and improvement of interferon-[gamma] glycosylation in Chinese hamster ovary cell culture

Authors: Gu, Xuejun, 1970-

Year: 2005

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/8796

Thesis Development of biologics for use in translational medicine

Jain, Saurabh Ashok · 2017 · The University of Edinburgh · DOI

Full title: Development of biologics for use in translational medicine

Authors: Jain, Saurabh Ashok

Year: 2017

Venue: The University of Edinburgh

DOI: http://hdl.handle.net/1842/21117

Thesis Improving monoclonal antibody production from Chinese hamster ovary cells

Donaldson, James · 2024 · The University of Edinburgh · DOI

Full title: Improving monoclonal antibody production from Chinese hamster ovary cells

Authors: Donaldson, James

Year: 2024

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/41771

Thesis Metabolomics-driven investigation of novel growth inhibitors in CHO cell bioprocessing

Johnston, Luke · 2025 · The University of Edinburgh · DOI

Full title: Metabolomics-driven investigation of novel growth inhibitors in CHO cell bioprocessing

Authors: Johnston, Luke

Year: 2025

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/44239

Thesis Process modelling and optimisation of biomolecular reactions and separations for advanced biopharmaceutical manufacturing

Jones, Wil · 2024 · The University of Edinburgh · DOI

Full title: Process modelling and optimisation of biomolecular reactions and separations for advanced biopharmaceutical manufacturing

Authors: Jones, Wil

Year: 2024

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/41822

Thesis CHO Cell Genetic Instability: From Transfection to Stable Cell Line

Cartwright, Joseph · 2016 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: CHO Cell Genetic Instability: From Transfection to Stable Cell Line

Authors: Cartwright, Joseph

Year: 2016

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/13986/1/Joe%20Cartwright%20Thesis.pdf

Thesis Effect of Cell Culture Environment on the Stability of IgG1

Anderson, Kimberley · 2018 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Effect of Cell Culture Environment on the Stability of IgG1

Authors: Anderson, Kimberley

Year: 2018

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/25641/1/Thesis_Kimberley_Anderson%20v5.0.docx

Thesis The Epigenetics (Histone PTMs) of Therapeutic Protein Production in CHO Cells

Hanson, Eleanor · 2019 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: The Epigenetics (Histone PTMs) of Therapeutic Protein Production in CHO Cells

Authors: Hanson, Eleanor

Year: 2019

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/22945/1/Final%20version%20of%20complete%20thesis-corrections.docx

Thesis Development of a High-Throughput Analytical Platform for the Characterisation of Biopharmaceuticals Generated from Multi-Gene Engineered CHO Cells

Lambiase, Giulia · 2022 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Development of a High-Throughput Analytical Platform for the Characterisation of Biopharmaceuticals Generated from Multi-Gene Engineered CHO Cells

Authors: Lambiase, Giulia

Year: 2022

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: oai:etheses.whiterose.ac.uk:30561

Thesis Synthetic Biology Platform Development for Manufacture of Next Generation Biologics

O'Neill, Pamela · 2022 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Synthetic Biology Platform Development for Manufacture of Next Generation Biologics

Authors: O'Neill, Pamela

Year: 2022

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: oai:etheses.whiterose.ac.uk:33526

Thesis Evaluation and characterisation of phenotypic heterogeneity in Chinese Hamster Ovary cell populations during long-term culture

Fernandez Martell, Alejandro · 2015 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Evaluation and characterisation of phenotypic heterogeneity in Chinese Hamster Ovary cell populations during long-term culture

Authors: Fernandez Martell, Alejandro

Year: 2015

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/9152/7/PhD%20thesis%20Alejandro%20Fernandez%20Martell%20%28final%20version%29.pdf

Thesis Expression and interaction studies of recombinant human monoclonal antibodies

Daniel X Johansson (19525819) · 2007 · Karolinska Institutet · DOI

Full title: Expression and interaction studies of recombinant human monoclonal antibodies

Authors: Daniel X Johansson (19525819)

Year: 2007

Venue: Karolinska Institutet

DOI: oai:figshare.com:article/26917288

Thesis Engineering the expression of "difficult-to-express" recombinant monoclonal antibodies in Chinese Hamster Ovary cells

Pybus, Leon P. · 2014 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Engineering the expression of "difficult-to-express" recombinant monoclonal antibodies in Chinese Hamster Ovary cells

Authors: Pybus, Leon P.

Year: 2014

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: oai:etheses.whiterose.ac.uk:6638

Thesis Expression of recombinant neutralizing anti-HIV-1 antibodies in bacteria and eukaryotic cells

Fayezeh Yari (19526845) · 2007 · Karolinska Institutet · DOI

Full title: Expression of recombinant neutralizing anti-HIV-1 antibodies in bacteria and eukaryotic cells

Authors: Fayezeh Yari (19526845)

Year: 2007

Venue: Karolinska Institutet

DOI: oai:figshare.com:article/26920558

Thesis Serum-free large-scale transient transfection of CHO cells

Derouazi, M.; Girard, P.; Van Tilborgh, F. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Serum-free large-scale transient transfection of CHO cells

Authors: Derouazi, M.; Girard, P.; Van Tilborgh, F.; Iglesias, K.; Muller, N.; Bertschinger, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7662

Thesis Manufacture of Recombinant Therapeutic Proteins Using Chinese Hamster Ovary Cells in Large-Scale Bioreactors History, Methods, and Perspectives

Wurm, Florian Maria; de Jesus, Maria · 2025 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Manufacture of Recombinant Therapeutic Proteins Using Chinese Hamster Ovary Cells in Large-Scale Bioreactors History, Methods, and Perspectives

Authors: Wurm, Florian Maria; de Jesus, Maria

Year: 2025

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/248255

Thesis Integration and stability of CHO amplicons containing plasmid sequences

Wurm, F. M.; Pallavicini, M. G.; Arathoon, R. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Integration and stability of CHO amplicons containing plasmid sequences

Authors: Wurm, F. M.; Pallavicini, M. G.; Arathoon, R.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7594

Thesis Low-temperature pausing of cultivated mammalian cells

Hunt, L.; Hacker, D. L.; Grosjean, F. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Low-temperature pausing of cultivated mammalian cells

Authors: Hunt, L.; Hacker, D. L.; Grosjean, F.; De Jesus, M.; Uebersax, L.; Jordan, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9752

Thesis Production of recombinant protein therapeutics in cultivated mammalian cells

Wurm, F. M. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Production of recombinant protein therapeutics in cultivated mammalian cells

Authors: Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7667

Thesis CHO expression of a novel human recombinant IgG1 anti-RhD antibody isolated by phage display

Miescher, S.; Zahn-Zabal, M.; De Jesus, M. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: CHO expression of a novel human recombinant IgG1 anti-RhD antibody isolated by phage display

Authors: Miescher, S.; Zahn-Zabal, M.; De Jesus, M.; Moudry, R.; Fisch, I.; Vogel, M.; Kobr, M.; Imboden, M. A.; Kragten, E.; Bichler, J.; Mermod, N.; Stadler, B. M.; Amstutz, H.; Wurm, F.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7585

Thesis Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells

Berger, Audrey; Le Fourn, Valerie; Masternak, Jacqueline et al. · 2020 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells

Authors: Berger, Audrey; Le Fourn, Valerie; Masternak, Jacqueline; Regamey, Alexandre; Bodenmann, Iris; Girod, Pierre-Alain; Mermod, Nicolas

Year: 2020

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/167095

Thesis Accelerating the development time of recombinant mammalian cell lines producing high titers of protein therapeutics

Chenuet, Sébastien · 2008 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Accelerating the development time of recombinant mammalian cell lines producing high titers of protein therapeutics

Authors: Chenuet, Sébastien

Year: 2008

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/25783

Thesis 25 years of recombinant proteins from reactor-grown cells — Where do we go from here?

Hacker, David L.; De Jesus, Maria; Wurm, Florian M. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: 25 years of recombinant proteins from reactor-grown cells — Where do we go from here?

Authors: Hacker, David L.; De Jesus, Maria; Wurm, Florian M.

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41353

Thesis Coexpression of acidic fibroblast growth factor enhances specific productivity and antibody titers in transiently transfected HEK293 cells

Backliwal, G; Hildinger, M; Chenuet, S et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Coexpression of acidic fibroblast growth factor enhances specific productivity and antibody titers in transiently transfected HEK293 cells

Authors: Backliwal, G; Hildinger, M; Chenuet, S; Dejesus, M; Wurm, FM

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41397

Thesis Development of a predictive model for cell growth in shaken bioreactors as a function of the effects of temperature, oxygen transfer rate and seeding cell concentration

Broccard, Gilles · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Development of a predictive model for cell growth in shaken bioreactors as a function of the effects of temperature, oxygen transfer rate and seeding cell concentration

Authors: Broccard, Gilles

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/44716

Thesis Calcium phosphate transfection generates mammalian recombinant cell lines with higher specific productivity than polyfection

Chenuet, S; Martinet, D; Besuchet-Schmutz, N et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Calcium phosphate transfection generates mammalian recombinant cell lines with higher specific productivity than polyfection

Authors: Chenuet, S; Martinet, D; Besuchet-Schmutz, N; Wicht, M; Jaccard, N; Bon, AC; Derouazi, M; Hacker, DL; Beckmann, JS; Wurm, FM

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41402

Thesis Recombinant therapeutic protein production in cultivated mammalian cells: current status and future prospects

Matasci, Mattia; Hacker, David L.; Baldi, Lucia et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Recombinant therapeutic protein production in cultivated mammalian cells: current status and future prospects

Authors: Matasci, Mattia; Hacker, David L.; Baldi, Lucia; Wurm, Florian M.

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/48115

Thesis Manufacturing recombinant proteins in kg-ton quantities using animal cells in bioreactors

De Jesus, Maria; Wurm, Florian M. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Manufacturing recombinant proteins in kg-ton quantities using animal cells in bioreactors

Authors: De Jesus, Maria; Wurm, Florian M.

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/64283

Thesis A simple high-yielding process for transient gene expression in CHO cells

Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia et al. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A simple high-yielding process for transient gene expression in CHO cells

Authors: Rajendra, Yashas; Kiseljak, Divor; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/70206

Thesis Novel orbital shake bioreactors for transient production of CHO derived IgGs

Stettler, Matthieu; Zhang, Xiaowei; Hacker, David L. et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Novel orbital shake bioreactors for transient production of CHO derived IgGs

Authors: Stettler, Matthieu; Zhang, Xiaowei; Hacker, David L.; De Jesus, Maria; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/83449

Thesis Disposable 600-mL orbitally shaken bioreactor for mammalian cell cultivation in suspension

Monteil, Dominique T.; Tontodonati, Giulia; Ghimire, Saroj et al. · 2013 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Disposable 600-mL orbitally shaken bioreactor for mammalian cell cultivation in suspension

Authors: Monteil, Dominique T.; Tontodonati, Giulia; Ghimire, Saroj; Baldi, Lucia; Hacker, David L.; Bürki, Cédric A.; Wurm, Florian M.

Year: 2013

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/91783

Thesis Lentiviral Vector-Mediated Gene Delivery for the Generation of Chinese Hamster Ovary Cell Lines with Improved Productivity and Stability

Oberbek, Agata · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Lentiviral Vector-Mediated Gene Delivery for the Generation of Chinese Hamster Ovary Cell Lines with Improved Productivity and Stability

Authors: Oberbek, Agata

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/52293

Thesis Glycan variability on a recombinant IgG antibody transiently produced in HEK-293E cells

Nallet, Sophie; Fornelli, Luca; Schmitt, Simone et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Glycan variability on a recombinant IgG antibody transiently produced in HEK-293E cells

Authors: Nallet, Sophie; Fornelli, Luca; Schmitt, Simone; Parra, Julien; Baldi, Lucia; Tsybin, Yury O.; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/79951

Thesis Generation of stable, high-producing cho cell lines by lentiviral vector-mediated gene transfer in serum-free suspension culture

Oberbek, Agata; Matasci, Mattia; Hacker, David L. et al. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Generation of stable, high-producing cho cell lines by lentiviral vector-mediated gene transfer in serum-free suspension culture

Authors: Oberbek, Agata; Matasci, Mattia; Hacker, David L.; Wurm, Florian M.

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/64220

Thesis Orbitally shaken bioreactors for mammalian cell culture : engineering characterization and bioprocess scale-up

Zhang, Xiaowei · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Orbitally shaken bioreactors for mammalian cell culture : engineering characterization and bioprocess scale-up

Authors: Zhang, Xiaowei

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41858

Thesis Efficient and reproducible mammalian cell bioprocesses without probes and controllers?

Tissot, Stéphanie; Oberbek, Agata; Reclari, Martino et al. · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Efficient and reproducible mammalian cell bioprocesses without probes and controllers?

Authors: Tissot, Stéphanie; Oberbek, Agata; Reclari, Martino; Dreyer, Matthieu; Hacker, David L.; Baldi, Lucia; Farhat, Mohamed; Wurm, Florian Maria

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/64893

Thesis Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

Zagari, Francesca; Jordan, Martin; Stettler, Matthieu et al. · 2012 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

Authors: Zagari, Francesca; Jordan, Martin; Stettler, Matthieu; Broly, Hervé; Wurm, Florian M.

Year: 2012

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/83342

Thesis Multigene expression in stable CHO cell pools generated with the piggyBac transposon system

Balasubramanian, Sowmya; Wurm, Florian M.; Hacker, David L. · 2017 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Multigene expression in stable CHO cell pools generated with the piggyBac transposon system

Authors: Balasubramanian, Sowmya; Wurm, Florian M.; Hacker, David L.

Year: 2017

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/133808

Thesis Rapid recombinant protein production from piggyBac transposon-mediated stable CHO cell pools

Balasubramanian, Sowmya; Matasci, Mattia; Kadlecova, Zuzana et al. · 2015 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Rapid recombinant protein production from piggyBac transposon-mediated stable CHO cell pools

Authors: Balasubramanian, Sowmya; Matasci, Mattia; Kadlecova, Zuzana; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2015

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/113975

Thesis Enhanced Plasmid DNA Utilization in Transiently Transfected CHO-DG44 Cells in the Presence of Polar Solvents

Rajendra, Yashas; Balasubramanian, Sowmya; Kiseljak, Divor et al. · 2016 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Enhanced Plasmid DNA Utilization in Transiently Transfected CHO-DG44 Cells in the Presence of Polar Solvents

Authors: Rajendra, Yashas; Balasubramanian, Sowmya; Kiseljak, Divor; Baldi, Lucia; Wurm, Florian M.; Hacker, David L.

Year: 2016

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/124119

Thesis A comparison of orbitally-shaken and stirred-tank bioreactors: pH modulation and bioreactor type affect CHO cell growth and protein glycosylation

Monteil, Dominique T.; Juvet, Valentin; Paz, Jonathan et al. · 2017 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A comparison of orbitally-shaken and stirred-tank bioreactors: pH modulation and bioreactor type affect CHO cell growth and protein glycosylation

Authors: Monteil, Dominique T.; Juvet, Valentin; Paz, Jonathan; Moniatte, Marc; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

Year: 2017

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/133807

Thesis Comparison of different bioreactors and media for the production of specific monoclonal IgA antibodies

Stoll, T. S.; Perregaux, C.; Von Stockar, U. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Comparison of different bioreactors and media for the production of specific monoclonal IgA antibodies

Authors: Stoll, T. S.; Perregaux, C.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/225995

Thesis Production of immunoglobulin A in different reactor configurations

Stoll, T.; Perregaux, C.; Von Stockar, U. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Production of immunoglobulin A in different reactor configurations

Authors: Stoll, T.; Perregaux, C.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/225985

Thesis CHO Quasispecies—Implications for Manufacturing Processes

Wurm, Florian · 2014 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: CHO Quasispecies—Implications for Manufacturing Processes

Authors: Wurm, Florian

Year: 2014

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/103490

Thesis Batch cultures of a hybridoma cell line performed with in situ ammonia removal

Schneider, Markus; El Alaoui, Mounia; von Stockar, Urs et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Batch cultures of a hybridoma cell line performed with in situ ammonia removal

Authors: Schneider, Markus; El Alaoui, Mounia; von Stockar, Urs; Marison, Ian W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226018

Thesis Characterization of Fibra-Cel® packed-bed bioreactors for the culture of CHO cells

Meuwly, Frédéric · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Characterization of Fibra-Cel® packed-bed bioreactors for the culture of CHO cells

Authors: Meuwly, Frédéric

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/218454

Thesis Process development for the production of monoclonal IgA antibodies that protect mucosal surfaces

Stoll, T. S.; Perregaux, C.; Stockar, U. von et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Process development for the production of monoclonal IgA antibodies that protect mucosal surfaces

Authors: Stoll, T. S.; Perregaux, C.; Stockar, U. von; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/225978

Thesis Automated microfluidic sorting of mammalian cells labeled with magnetic microparticles for those that efficiently express and secrete a protein of interest

Droz, Xuan; Harraghy, Niamh; Lancon, Etienne et al. · 2017 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Automated microfluidic sorting of mammalian cells labeled with magnetic microparticles for those that efficiently express and secrete a protein of interest

Authors: Droz, Xuan; Harraghy, Niamh; Lancon, Etienne; Le Fourn, Valerie; Calabrese, David; Colombet, Thierry; Liechti, Pascal; Rida, Amar; Girod, Pierre-Alain; Mermod, Nicolas

Year: 2017

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/138887

Thesis Mid-infrared spectroscopic monitoring of animal cell culture bioreactor processes

Rhiel, M.; Ziegler, T.; Ducommun, P. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Mid-infrared spectroscopic monitoring of animal cell culture bioreactor processes

Authors: Rhiel, M.; Ziegler, T.; Ducommun, P.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226036

Thesis Monitoring of temperature effects on animal cell metabolism in a packed bed process

Ducommun, P.; Rueux, P. A.; Kadouri, A. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Monitoring of temperature effects on animal cell metabolism in a packed bed process

Authors: Ducommun, P.; Rueux, P. A.; Kadouri, A.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226069

Thesis Characterization of monoclonal IgA production and activity in hollow-fiber and fluidized-bed reactors

Stoll, T. S.; Ruffieux, P. A.; Lluella, E. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Characterization of monoclonal IgA production and activity in hollow-fiber and fluidized-bed reactors

Authors: Stoll, T. S.; Ruffieux, P. A.; Lluella, E.; von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226009

Thesis Online calorimetry as a technique for process monitoring and control in biotechnology

vonStockar, Urs; Duboc, Philippe; Menoud, Laurent et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Online calorimetry as a technique for process monitoring and control in biotechnology

Authors: vonStockar, Urs; Duboc, Philippe; Menoud, Laurent; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226013

Thesis All-in-one bioprocess monitoring with a mid-IR spectroscopic sensor

Rhiel, Martin; Cannizzaro, Christopher; Marison, Ian et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: All-in-one bioprocess monitoring with a mid-IR spectroscopic sensor

Authors: Rhiel, Martin; Cannizzaro, Christopher; Marison, Ian; von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226049

Thesis Effects of culture conditions on the production and quality of monoclonal IgA

Stoll, T. S.; Chappaz, A.; von Stockar, U. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Effects of culture conditions on the production and quality of monoclonal IgA

Authors: Stoll, T. S.; Chappaz, A.; von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226015

Thesis Systematic improvement of a chemically-defined protein-free medium for hybridoma growth and monoclonal antibody production

Stoll, T. S.; Muhlethaler, K.; von Stockar, U. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Systematic improvement of a chemically-defined protein-free medium for hybridoma growth and monoclonal antibody production

Authors: Stoll, T. S.; Muhlethaler, K.; von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/225998

Thesis The role of vitamins and amino acids on hybridoma growth and monoclonal antibody production

Ducommun, Paul; Ruffieux, Pierre-Alain; von Stockar, Urs et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: The role of vitamins and amino acids on hybridoma growth and monoclonal antibody production

Authors: Ducommun, Paul; Ruffieux, Pierre-Alain; von Stockar, Urs; Marison, Ian

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226050

Thesis On-line determination of animal cell concentration in two industrial high-density culture processes by dielectric spectroscopy

Ducommun, P.; Kadouri, A.; Von Stockar, U. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-line determination of animal cell concentration in two industrial high-density culture processes by dielectric spectroscopy

Authors: Ducommun, P.; Kadouri, A.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226068

Thesis Real-time in situ monitoring of freely suspended and immobilized cell cultures based on mid-infrared spectroscopic measurements

Rhiel, Martin; Ducommun, Paul; Bolzonella, Ivan et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Real-time in situ monitoring of freely suspended and immobilized cell cultures based on mid-infrared spectroscopic measurements

Authors: Rhiel, Martin; Ducommun, Paul; Bolzonella, Ivan; Marison, Ian; Von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226062

Thesis On-line determination of animal cell concentration

Ducommun, P.; Bolzonella, I.; Rhiel, M. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-line determination of animal cell concentration

Authors: Ducommun, P.; Bolzonella, I.; Rhiel, M.; Pugeaud, P.; von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226053

Thesis Factors affecting the production and quality of IgA antibodies active against V. cholerae

Marison, Ian; Stoll, Thibaud S.; Lullau, Elke et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Factors affecting the production and quality of IgA antibodies active against V. cholerae

Authors: Marison, Ian; Stoll, Thibaud S.; Lullau, Elke; Von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226014

Thesis Biotechnology in Lausanne. The Rh D project

Von Stockar, Urs; Kragten, Eddy; Marison, Ian W. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Biotechnology in Lausanne. The Rh D project

Authors: Von Stockar, Urs; Kragten, Eddy; Marison, Ian W.; Amstutz, Hanspeter; Miescher, Sylvia; Fisch, Igor; Mermod, Nicolas; De Jesus, Maria; Freitag, Ruth; Wurm, Florian

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226042

Thesis The effect of cell line, transfection procedure and reactor conditions on the glycosylation of recombinant human anti-rhesus D IGG1

Nahrgang, S.; Kragten, E.; De Jesus, M. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: The effect of cell line, transfection procedure and reactor conditions on the glycosylation of recombinant human anti-rhesus D IGG1

Authors: Nahrgang, S.; Kragten, E.; De Jesus, M.; Bourgeois, M.; Dejardin, S.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226039

Thesis A new method for on-line measurement of the volumetric oxygen uptake rate in membrane aerated animal cell cultures

Ducommun, P.; Ruffieux, P. A.; Furter, M. P. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A new method for on-line measurement of the volumetric oxygen uptake rate in membrane aerated animal cell cultures

Authors: Ducommun, P.; Ruffieux, P. A.; Furter, M. P.; Marison, I.; von Stockar, U.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226045

Thesis On-line biomass monitoring with scanning dielectric spectroscopy

Cannizzaro, Christopher M.; Valentinotti, Sergio; Marison, Ian W. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-line biomass monitoring with scanning dielectric spectroscopy

Authors: Cannizzaro, Christopher M.; Valentinotti, Sergio; Marison, Ian W.; von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226087

Thesis On-line biomass monitoring of CHO perfusion culture with scanning dielectric spectroscopy

Cannizzaro, Christopher; Guegerli, Raphael; Marison, Ian et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: On-line biomass monitoring of CHO perfusion culture with scanning dielectric spectroscopy

Authors: Cannizzaro, Christopher; Guegerli, Raphael; Marison, Ian; von Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226088

Thesis Metabolic flux analysis of hybridoma cells in different culture media using mass balances

Bonarius, Hendrik P. J.; Hatzimanikatis, Vassily; Meesters, Koen P. H. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Metabolic flux analysis of hybridoma cells in different culture media using mass balances

Authors: Bonarius, Hendrik P. J.; Hatzimanikatis, Vassily; Meesters, Koen P. H.; de Gooijer, Cornelis D.; Schmid, Georg; Tramper, Johannes

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/238768

Thesis CHARACTERIZING CELL LINE AND MEDIA PERFORMANCE OVER EXTENDED PERIODS THROUGH COMPUTATIONAL AND BIOINFORMATIC APPROACHES

Rapp, Kent Michael · 2025 · Johns Hopkins University · DOI

Full title: CHARACTERIZING CELL LINE AND MEDIA PERFORMANCE OVER EXTENDED PERIODS THROUGH COMPUTATIONAL AND BIOINFORMATIC APPROACHES

Authors: Rapp, Kent Michael

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70290

Thesis ENGINEERING BIOSENSOR CELL LINES TO INVESTIGATE INTRACELLULAR IMPACTS OF MAMMALIAN BIOPROCESSES

McFarland, Kevin Stephen · 2023 · Johns Hopkins University · DOI

Full title: ENGINEERING BIOSENSOR CELL LINES TO INVESTIGATE INTRACELLULAR IMPACTS OF MAMMALIAN BIOPROCESSES

Authors: McFarland, Kevin Stephen

Year: 2023

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/68933

Thesis Investigating the Use of Dipeptides as Singular Amino Acid Replacements in Chinese Hamster Ovary Cell Cultures

Mitchell, Makayla N · 2025 · Johns Hopkins University · DOI

Full title: Investigating the Use of Dipeptides as Singular Amino Acid Replacements in Chinese Hamster Ovary Cell Cultures

Authors: Mitchell, Makayla N

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70799

Thesis STRUCTURAL IMPLICATIONS OF GLUCOSE AND COPPER AVAILABILITY ON GLYCATION PROCESSES IN CHINESE HAMSTER OVARIAN (CHO) CELL-DERIVED PROTEINS

Vasamsetti, Sree Lakshmi Harita · 2025 · Johns Hopkins University · DOI

Full title: STRUCTURAL IMPLICATIONS OF GLUCOSE AND COPPER AVAILABILITY ON GLYCATION PROCESSES IN CHINESE HAMSTER OVARIAN (CHO) CELL-DERIVED PROTEINS

Authors: Vasamsetti, Sree Lakshmi Harita

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70784

Thesis BRIDGING EXPERIMENTAL AND IN-SILICO METHODS FOR ADVANCED MAMMALIAN BIOMANUFACTURING OPTIMIZATION

Ndahiro, Nelson · 2025 · Johns Hopkins University · DOI

Full title: BRIDGING EXPERIMENTAL AND IN-SILICO METHODS FOR ADVANCED MAMMALIAN BIOMANUFACTURING OPTIMIZATION

Authors: Ndahiro, Nelson

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70287

Thesis Metabolic-flux analysis of mammalian-cell culture

Bonarius, H.P.J. · 1998 · Wageningen University & Research · DOI

Full title: Metabolic-flux analysis of mammalian-cell culture

Authors: Bonarius, H.P.J.

Year: 1998

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/metabolic-flux-analysis-of-mammalian-cell-culture

Thesis Understanding mammalian cell metabolism and developing cell culture strategies for enhanced manufacturing of biotherapeutics

Ladiwala, Pranay · 2025 · Johns Hopkins University · DOI

Full title: Understanding mammalian cell metabolism and developing cell culture strategies for enhanced manufacturing of biotherapeutics

Authors: Ladiwala, Pranay

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70273

Thesis A scoping review of supervised learning modelling and data-driven optimisation in monoclonal antibody process development

Pham, TD; Manapragada, C; Sun, Y et al. · 2023 · University of Melbourne · DOI

Full title: A scoping review of supervised learning modelling and data-driven optimisation in monoclonal antibody process development

Authors: Pham, TD; Manapragada, C; Sun, Y; Bassett, R; Aickelin, U

Year: 2023

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/325201

Thesis Tuning Post-Translational Modifications in Mammalian Cells: Exploring Media Optimization and Gene Editing Strategies

Aliyu, Lateef · 2025 · Johns Hopkins University · DOI

Full title: Tuning Post-Translational Modifications in Mammalian Cells: Exploring Media Optimization and Gene Editing Strategies

Authors: Aliyu, Lateef

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70660

Thesis Acoustic perfusion processes for hybridoma cultures: viability, cell cycle and metabolic analysis

Dalm, M.C.F. · 2007 · Wageningen University & Research · DOI

Full title: Acoustic perfusion processes for hybridoma cultures: viability, cell cycle and metabolic analysis

Authors: Dalm, M.C.F.

Year: 2007

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/acoustic-perfusion-processes-for-hybridoma-cultures-viability-cel

Thesis Discovering Changes in Cell Stability Using Process Mining: A Case Study

Zhou, J; Armas-Cervantes, A; Bozorgi, ZD et al. · 2024 · University of Melbourne · DOI

Full title: Discovering Changes in Cell Stability Using Process Mining: A Case Study

Authors: Zhou, J; Armas-Cervantes, A; Bozorgi, ZD; Otte, E; Polyvyanyy, A

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/354056

Thesis Characterization and optimization of a CHO antibody manufacturing process

Reger, Lucas Nik · 2025 · Wageningen University & Research · DOI

Full title: Characterization and optimization of a CHO antibody manufacturing process

Authors: Reger, Lucas Nik

Year: 2025

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/characterization-and-optimization-of-a-cho-antibody-manufacturing

Thesis Design, characterization and application of the multiple air-lift loop bioreactor

Bakker, W.A.M. · 1995 · Wageningen University & Research · DOI

Full title: Design, characterization and application of the multiple air-lift loop bioreactor

Authors: Bakker, W.A.M.

Year: 1995

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/design-characterization-and-application-of-the-multiple-air-lift-

Thesis Monoclonal Antibody Production and Purification

McMahon, Hope E; Schwartz, Jessica W; Ray, Shritama · 2023 · University of Pennsylvania · DOI

Full title: Monoclonal Antibody Production and Purification

Authors: McMahon, Hope E; Schwartz, Jessica W; Ray, Shritama

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/5925

Thesis Scale-down of CHO cell fed-batch cultures

Pan, Xiao · 2018 · Wageningen University & Research · DOI

Full title: Scale-down of CHO cell fed-batch cultures

Authors: Pan, Xiao

Year: 2018

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/scale-down-of-cho-cell-fed-batch-cultures

Thesis Transcriptomic profiling as a tool to characterize CHO cell processes

Al Sayyari, Abdulaziz Abdullah · 2018 · Wageningen University & Research · DOI

Full title: Transcriptomic profiling as a tool to characterize CHO cell processes

Authors: Al Sayyari, Abdulaziz Abdullah

Year: 2018

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/transcriptomic-profiling-as-a-tool-to-characterize-cho-cell-proce

Thesis Growth and death of animal cells in bioreactors

Martens, D.E. · 1996 · Wageningen University & Research · DOI

Full title: Growth and death of animal cells in bioreactors

Authors: Martens, D.E.

Year: 1996

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/growth-and-death-of-animal-cells-in-bioreactors

Thesis Development and validation of a hybrid model for prediction of viable cell density, titer and cumulative glucose consumption in a mammalian cell culture system

Yatipanthalawa, BS; Wallace Fitzsimons, SE; Horning, T et al. · 2024 · University of Melbourne · DOI

Full title: Development and validation of a hybrid model for prediction of viable cell density, titer and cumulative glucose consumption in a mammalian cell culture system

Authors: Yatipanthalawa, BS; Wallace Fitzsimons, SE; Horning, T; Lee, YY; Gras, SL

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/345116

Thesis A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

Fan, Yuzhou; Jimenez Del Val, Ioscani; Müller, Christian et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

Authors: Fan, Yuzhou; Jimenez Del Val, Ioscani; Müller, Christian; Lund, Anne Mathilde; Wagtberg Sen, Jette; Rasmussen, Søren Kofoed; Kontoravdi, Cleo; Baycin-Hizal, Deniz; Betenbaugh, Michael J.; Weilguny, Dietmar; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/032ff7ec-9b40-4a61-8f15-f7c40fa6a14e

Thesis Reprogramming amino acid catabolism in CHO cells with CRISPR-Cas9 genome editing improves cell growth and reduces by-product secretion

Ley, Daniel; Pereira, Sara; Pedersen, Lasse Ebdrup et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Reprogramming amino acid catabolism in CHO cells with CRISPR-Cas9 genome editing improves cell growth and reduces by-product secretion

Authors: Ley, Daniel; Pereira, Sara; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Hefzi, Hooman; Lund, Anne Mathilde; Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Wulff, Tune; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/02fc00d6-9e88-4356-a0b4-d3fe8193bcdd

Thesis The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

Xu, Xun; Pan, Shengkai; Liu, Xin et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

Authors: Xu, Xun; Pan, Shengkai; Liu, Xin; Chen, Wenbin; Xie, Min; Wang, Wenliang; Wang, Jun; Nagarajan, Harish; Lewis, Nathan; Famili, Iman; Palsson, Bernhard O.; Cai, Zhiming; Gui, Yaoting; Hammond, Stephanie; Lee, Kelvin H.; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Neff, Norma; Passarelli, Benedetto; Koh, Winston; Fan, H. Christina; Wang, Jianbin; Quake, Stephen R.; Betenbaugh, Michael; Palsson, Bernhard; id_orcid 0000-0003-2357-6785; Wang, Jun

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/153bbfd3-ab45-4bfe-bf95-4ccf498498d5

Thesis Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells

Saghaleyni, Rasool; Malm, Magdalena; Moruzzi, Noah et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells

Authors: Saghaleyni, Rasool; Malm, Magdalena; Moruzzi, Noah; Zrimec, Jan; Razavi, Ronia; Wistbacka, Num; Thorell, Hannes; Pintar, Anton; Hober, Andreas; Edfors, Fredrik; Chotteau, Veronique; Berggren, Per Olof; Grassi, Luigi; Zelezniak, Aleksej; Svensson, Thomas; Hatton, Diane; Nielsen, Jens; Robinson, Jonathan L.; Rockberg, Johan

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2d7082ac-461c-4bfd-9506-aee94ce2430e

Thesis Engineer medium and feed for modulating N-glycosylation of recombinant protein production in CHO cell culture

Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Engineer medium and feed for modulating N-glycosylation of recombinant protein production in CHO cell culture

Authors: Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0bd0b7c5-a59e-4460-9d0c-f80856bbbbe1

Thesis Systems metabolic engineering

Hesselberg-Thomsen, Viktor; id_orcid 0000-0001-6929-3671 · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Systems metabolic engineering

Authors: Hesselberg-Thomsen, Viktor; id_orcid 0000-0001-6929-3671

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/18523551-e95d-4dca-8278-5501b8e2ec1d

Thesis Method for reducing ammonium and lactate production in cho cells

Ley, Daniel; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808 et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Method for reducing ammonium and lactate production in cho cells

Authors: Ley, Daniel; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2eca9af1-d5e3-427f-a8d4-142c07400b20

Thesis CHO On A Detox: Removing By-Product Formation Through Cell Engineering

Pereira, Sara; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: CHO On A Detox: Removing By-Product Formation Through Cell Engineering

Authors: Pereira, Sara; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/16746af6-dbf5-46ee-a6a0-d5c8bf3c3b88

Thesis N-Glycosylation optimization of recombinant antibodies in CHO cell through process and metabolic engineering

Fan, Yuzhou · 2015 · Technical University of Denmark (DTU) · DOI

Full title: N-Glycosylation optimization of recombinant antibodies in CHO cell through process and metabolic engineering

Authors: Fan, Yuzhou

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0d46b1c0-0617-4c4e-8295-079e1eddaf3e

Thesis Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing

Lee, Jae Seong; Park, Jin Hyoung; Kwang Ha, Tae et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing

Authors: Lee, Jae Seong; Park, Jin Hyoung; Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Samoudi, Mojtaba; Lewis, Nathan E.; Palsson, Bernhard O.; id_orcid 0000-0003-2357-6785; Kildegaard, Helene Faustrup; Min Lee, Gyun

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0ae89c9f-9a27-4554-a9b0-2af9aa0614a9

Thesis Single-Batch Expression of an Experimental Recombinant Snakebite Antivenom Based on an Oligoclonal Mixture of Human Monoclonal Antibodies

Adams, Anna C.; Grav, Lise M.; id_orcid 0000-0001-8042-7108 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Single-Batch Expression of an Experimental Recombinant Snakebite Antivenom Based on an Oligoclonal Mixture of Human Monoclonal Antibodies

Authors: Adams, Anna C.; Grav, Lise M.; id_orcid 0000-0001-8042-7108; Ahmadi, Shirin; id_orcid 0000-0002-4131-583X; Holst Dahl, Camilla; Ljungars, Anne; id_orcid 0000-0002-2158-0601; Laustsen, Andreas H.; id_orcid 0000-0001-6918-5574; Nielsen, Lars K.

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1cacecb6-2d02-484b-8855-606d116d8855

Thesis Engineered CHO cells for production of diverse, homogeneous glycoproteins

Yang, Zhang; Wang, Shengjun; Halim, Adnan et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Engineered CHO cells for production of diverse, homogeneous glycoproteins

Authors: Yang, Zhang; Wang, Shengjun; Halim, Adnan; Schulz, Morten Alder; Frodin, Morten; Rahman, Shamim H.; Vester-Christensen, Malene Bech; Behrens, Carsten; Kristensen, Claus; Vakhrushev, Sergey Y.; Bennett, Eric Paul; Wandall, Hans H.; Clausen, Henrik

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/003c3b4e-4454-43e4-abe6-4365fa07ce9f

Thesis Improving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines

Kim, Che Lin; Min Lee, Gyun · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Improving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines

Authors: Kim, Che Lin; Min Lee, Gyun

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/28aaa920-fbdb-454f-9c73-2206da4ef39e

Thesis A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

Lund, Anne Mathilde; Kildegaard, Helene Faustrup; Petersen, Maja Borup Kjær et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

Authors: Lund, Anne Mathilde; Kildegaard, Helene Faustrup; Petersen, Maja Borup Kjær; Rank, Julie; Hansen, Bjarne Gram; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Mortensen, Uffe Hasbro; id_orcid 0000-0002-7794-7273

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1e6b9cdd-536a-420a-b808-622781069950

Thesis Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Hansen, Henning Gram; Nilsson, Claes Nymand; Lund, Anne Mathilde et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Authors: Hansen, Henning Gram; Nilsson, Claes Nymand; Lund, Anne Mathilde; Kol, Stefan; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lundqvist, Magnus; Rockberg, Johan; Min Lee, Gyun; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/41719bc3-f624-40be-ba5e-4449c22aac7f

Thesis Glycoengineering in CHO cells: Advances in systems biology

Tejwani, Vijay; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808 et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Glycoengineering in CHO cells: Advances in systems biology

Authors: Tejwani, Vijay; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Nam, Jong Hyun; Sharfstein, Susan T

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/18d1eb12-342d-4d7e-bfaa-aad1a918cc13

Thesis Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Martínez-Monge, I.; Martínez, C.; Decker, M. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Authors: Martínez-Monge, I.; Martínez, C.; Decker, M.; Udugama, I. A.; Marín de Mas, I.; Gernaey, K. V.; id_orcid 0000-0002-0364-1773; Nielsen, L. K.

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3b1685d4-5ab9-4737-b414-d28fecf9b9eb

Thesis Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

Pereira, Sara; Kildegaard, Helene F.; Andersen, Mikael R. et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

Authors: Pereira, Sara; Kildegaard, Helene F.; Andersen, Mikael R.; id_orcid 0000-0003-4794-6808

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/28b6ee0a-2f57-47f3-ba14-6a113e9c7800

Thesis A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism

Hefzi, Hooman; Ang, Kok Siong; Hanscho, Michael et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism

Authors: Hefzi, Hooman; Ang, Kok Siong; Hanscho, Michael; Bordbar, Aarash; Ruckerbauer, David; Lakshmanan, Meiyappan; Orellana, Camila A.; Baycin-Hizal, Deniz; Huang, Yingxiang; Ley, Daniel; Martinez, Veronica S.; Kyriakopoulos, Sarantos; Jiménez, Natalia E.; Zielinski, Daniel C.; Quek, Lake-Ee; Wulff, Tune; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Li, Shangzhong; Lee, Jae Seong; Paglia, Giuseppe; Loira, Nicolas; Spahn, Philipp N.; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Gutierrez, Jahir M.; King, Zachary A.; Lund, Anne Mathilde; Nagarajan, Harish; Thomas, Alex; Abdel-Haleem, Alyaa M.; Zanghellini, Juergen; Kildegaard, Helene Faustrup; Voldborg, Bjørn Gunnar; id_orcid 0000-0002-7005-1642; Gerdtzen, Ziomara P.; Betenbaugh, Michael J.; Palsson, Bernhard; id_orcid 0000-0003-2357-6785; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Nielsen, Lars K.; Borth, Nicole; Lee, Dong-Yup; Lewis, Nathan E.

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2f8bb3cd-eb0c-46f7-b39b-3791d7c86d1d

Thesis A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells

Schmieder, Valerie; Novak, Neža; Dhiman, Heena et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells

Authors: Schmieder, Valerie; Novak, Neža; Dhiman, Heena; Nguyen, Ly Ngoc; Serafimova, Evgenija; Klanert, Gerald; Baumann, Martina; Kildegaard, Helene Faustrup; Borth, Nicole

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2952ac8e-767c-4605-811b-710e6cd4ba19

Thesis The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells

Tian, Weihua; Ye, Zilu; Wang, Shengjun et al. · 2019 · University of Copenhagen · DOI

Full title: The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells

Authors: Tian, Weihua; Ye, Zilu; Wang, Shengjun; Schulz, Morten Alder; Van Coillie, Julie; Sun, Lingbo; Chen, Yen-Hsi; Narimatsu, Yoshiki; Hansen, Lars; Kristensen, Claus; Mandel, Ulla; Bennett, Eric Paul; Jabbarzadeh-Tabrizi, Siamak; Schiffmann, Raphael; Shen, Jin-Song; Vakhrushev, Sergey Y.; Clausen, Henrik; Yang, Zhang

Year: 2019

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/3e2a06f8-14f4-4325-8421-d29ab3624404

Thesis The emerging CHO systems biology era: harnessing the ‘omics revolution for biotechnology

Kildegaard, Helene Faustrup; Baycin-Hizal, Deniz; Lewis, Nathan et al. · 2013 · Technical University of Denmark (DTU) · DOI

Full title: The emerging CHO systems biology era: harnessing the ‘omics revolution for biotechnology

Authors: Kildegaard, Helene Faustrup; Baycin-Hizal, Deniz; Lewis, Nathan; Betenbaugh, Michael

Year: 2013

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3d14cbfe-7a58-4483-8e29-db98b61fd906

Thesis A Markov chain model for N-linked protein glycosylation – towards a low-parameter tool for model-driven glycoengineering

Spahn, Philipp N.; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787 et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: A Markov chain model for N-linked protein glycosylation – towards a low-parameter tool for model-driven glycoengineering

Authors: Spahn, Philipp N.; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Hansen, Henning Gram; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Kildegaard, Helene Faustrup; Lewis, Nathan

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4c6e0b4e-131d-4ea4-b2cd-1331877ad8bd

Thesis Targeting miRNAs with CRISPR/Cas9 to Improve Recombinant Protein Production of CHO Cells

Kellner, Kevin; Solanki, Ankur; Amann, Thomas et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Targeting miRNAs with CRISPR/Cas9 to Improve Recombinant Protein Production of CHO Cells

Authors: Kellner, Kevin; Solanki, Ankur; Amann, Thomas; Lao, Nga; Barron, Niall

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/437280a5-1393-422a-9a9d-00f68443909f

Thesis Factors affecting the quality of therapeutic proteins in recombinant Chinese hamster ovary cell culture

Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Kim, Dongil et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Factors affecting the quality of therapeutic proteins in recombinant Chinese hamster ovary cell culture

Authors: Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Kim, Dongil; Kim, Che Lin; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lee, Gyun Min

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/464b29f2-bedf-4a85-b9c3-c061a52c6df4

Thesis Fed-batch CHO cell culture for lab-scale antibody production

Fan, Yuzhou; Ley, Daniel; Andersen, Mikael Rørdam et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Fed-batch CHO cell culture for lab-scale antibody production

Authors: Fan, Yuzhou; Ley, Daniel; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/54dbf94e-f74b-4dd6-a33d-3f93ac979d1d

Thesis Deciphering Cytokine production in CHO cells by Integrating Cell Line Engineering and Omics Strategies

Scapin, Giulia; id_orcid 0000-0002-2978-9549 · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Deciphering Cytokine production in CHO cells by Integrating Cell Line Engineering and Omics Strategies

Authors: Scapin, Giulia; id_orcid 0000-0002-2978-9549

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4d3f74ae-375a-4103-9968-3b362af8aa22

Thesis BiP Inducer X: An ER Stress Inhibitor for Enhancing Recombinant Antibody Production in CHO Cell Culture

Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders H et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: BiP Inducer X: An ER Stress Inhibitor for Enhancing Recombinant Antibody Production in CHO Cell Culture

Authors: Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders H; id_orcid 0000-0002-6007-4787; Kildegaard, Helene Faustrup; Min Lee, Gyun

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4bb8049c-8448-48b2-849a-893bbcc3e831

Thesis Improving Recombinant Antibody Production Using FcBAR: An In Situ Approach to Detect and Amplify Protein-Protein Interactions

Wu, Mina Ying Min; Rocamora, Frances; Samoudi, Mojtaba et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Improving Recombinant Antibody Production Using FcBAR: An In Situ Approach to Detect and Amplify Protein-Protein Interactions

Authors: Wu, Mina Ying Min; Rocamora, Frances; Samoudi, Mojtaba; Robinson, Caressa M.; Kuo, Chih-Chung; Pristovšek, Nuša; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Kildegaard, Helene Faustrup; Lee, Gyun Min; Campos, Alexandre Rosa; Lewis, Nathan E.

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/47083ccf-1089-4f74-b875-790ddbd3f9cf

Thesis Application of CRISPR/Cas9 Genome Editing to Improve Recombinant Protein Production in CHO Cells

Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Rojek, Johan Blatt et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Application of CRISPR/Cas9 Genome Editing to Improve Recombinant Protein Production in CHO Cells

Authors: Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Rojek, Johan Blatt; la Cour Karottki, Karen Julie; Lee, Jae Seong; Kildegaard, Helene Faustrup

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/681c1edc-1d94-47ca-96a9-99e6989a2708

Thesis Minimizing Clonal Variation during Mammalian Cell Line Engineering for Improved Systems Biology Data Generation

Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Sergeeva, Daria et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Minimizing Clonal Variation during Mammalian Cell Line Engineering for Improved Systems Biology Data Generation

Authors: Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Sergeeva, Daria; Lee, Jae Seong; Marín de Mas, Igor; Lewis, Nathan E.; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Nielsen, Lars Keld; Min Lee, Gyun; Kildegaard, Helene Faustrup

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/617f549d-1121-49ca-a9c3-2874643dbc6a

Thesis Impact of cellular stress on recombinant monoclonal antibody produced by high yielding Chinese Hamster Ovary (CHO) cell cultures in bioreactors

Chevallier, Valentine · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Impact of cellular stress on recombinant monoclonal antibody produced by high yielding Chinese Hamster Ovary (CHO) cell cultures in bioreactors

Authors: Chevallier, Valentine

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/563b6ddf-77b7-40a0-94d6-f435d6d8a1ca

Thesis CRISPR/Cas9-mediated genome engineering of CHO cell factories: application and perspectives

Lee, Jae Seong; Grav, Lise Marie; id_orcid 0000-0001-8042-7108 et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: CRISPR/Cas9-mediated genome engineering of CHO cell factories: application and perspectives

Authors: Lee, Jae Seong; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lewis, Nathan E.; Kildegaard, Helene Faustrup

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/52fc8089-3984-4fdf-92ff-f1dff24e34f2

Thesis Unraveling productivity-enhancing genes in Chinese hamster ovary cells via CRISPR activation screening using recombinase-mediated cassette exchange system

Baek, Minhye; Kim, Che Lin; Kim, Su Hyun et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Unraveling productivity-enhancing genes in Chinese hamster ovary cells via CRISPR activation screening using recombinase-mediated cassette exchange system

Authors: Baek, Minhye; Kim, Che Lin; Kim, Su Hyun; la Cour Karottki, Karen Julie; Hefzi, Hooman; id_orcid 0009-0003-4067-6224; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Lewis, Nathan E.; Lee, Jae Seong; Lee, Gyun Min

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4ec45fdf-f45d-42f6-86e6-b494eebc0b2a

Thesis Accelerated Homology-Directed Targeted Integration of Transgenes in Chinese Hamster Ovary Cells Via CRISPR/Cas9 and Fluorescent Enrichment

Lee, Jae Seong; Grav, Lise Marie; id_orcid 0000-0001-8042-7108 et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Accelerated Homology-Directed Targeted Integration of Transgenes in Chinese Hamster Ovary Cells Via CRISPR/Cas9 and Fluorescent Enrichment

Authors: Lee, Jae Seong; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Min Lee, Gyun; Kildegaard, Helene Faustrup

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/574bc003-4903-41b7-ab18-c218319b1350

Thesis Cell culture process dynamics and metabolic flux distributions using hybrid models

Kailasanathan, Rajiv; Sivaram, Abhishek; Mansouri, Seyed Soheil et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Cell culture process dynamics and metabolic flux distributions using hybrid models

Authors: Kailasanathan, Rajiv; Sivaram, Abhishek; Mansouri, Seyed Soheil; id_orcid 0000-0002-0924-4947

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/572e7d61-3351-4ced-b2f5-6b9e4ceab22f

Thesis Developing Tools for Improved and Predictable Recombinant Protein Production in CHO Cells

Pristovšek, Nuša · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Developing Tools for Improved and Predictable Recombinant Protein Production in CHO Cells

Authors: Pristovšek, Nuša

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/64616d27-ec57-4e4b-8166-fddb72ce82e5

Thesis A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes

Karottki, Karen Julie la Cour; Hefzi, Hooman; Li, Songyuan et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes

Authors: Karottki, Karen Julie la Cour; Hefzi, Hooman; Li, Songyuan; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Spahn, Philipp N.; Joshi, Chintan; Ruckerbauer, David; Bort, Juan A.Hernandez; Thomas, Alex; Lee, Jae Seong; Borth, Nicole; Lee, Gyun Min; Kildegaard, Helene Faustrup; Lewis, Nathan E.

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/6c630eef-615d-4310-b404-6413d4cc1932

Thesis The GalNAc-type O-Glycoproteome of CHO Cells Characterized by the SimpleCell Strategy

Zhang, Yang; Halim, Adnan; Narimatsu, Yoshiki et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: The GalNAc-type O-Glycoproteome of CHO Cells Characterized by the SimpleCell Strategy

Authors: Zhang, Yang; Halim, Adnan; Narimatsu, Yoshiki; Jitendra Joshi, Hiren; Steentoft, Catharina; Gram Schjoldager, Katrine Ter-Borch; Alder Schulz, Morten; Sealover, Natalie R.; Kayser, Kevin J.; Paul Bennett, Eric; Levery, Steven B.; Vakhrushev, Sergey Y.; Clausen, Henrik

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5ebfd0ee-130e-4389-ae10-57be9960dab0

Thesis Data-Driven Cell Engineering of Chinese Hamster Ovary Cells through Machine Learning

Zaragoza, Jose Manuel Camacho · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Data-Driven Cell Engineering of Chinese Hamster Ovary Cells through Machine Learning

Authors: Zaragoza, Jose Manuel Camacho

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5ba1a67a-d916-46d2-be02-2dcbaa66a091

Thesis The cell density effect in animal cell-based bioprocessing:Questions, insights and perspectives

Lavado-García, Jesús; Pérez-Rubio, Pol; Cervera, Laura et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: The cell density effect in animal cell-based bioprocessing:Questions, insights and perspectives

Authors: Lavado-García, Jesús; Pérez-Rubio, Pol; Cervera, Laura; Gòdia, Francesc

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/59d319c9-b38b-40f6-a360-60ecc53c3457

Thesis Concomitant consumption of glucose and lactate: A novel batch production process for CHO cells

Martínez-Monge, I.; Comas, P.; Triquell, J. et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Concomitant consumption of glucose and lactate: A novel batch production process for CHO cells

Authors: Martínez-Monge, I.; Comas, P.; Triquell, J.; Casablancas, A.; Lecina, M.; Paredes, C.J.; Cairó, J.J.

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5dbc1c02-f271-4f18-8ccd-422ca2b145c2

Thesis Toward genome-scale models of the Chinese hamster ovary cells: incentives, status and perspectives

Kaas, Christian Schrøder; Fan, Yuzhou; Weilguny, Dietmar et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: Toward genome-scale models of the Chinese hamster ovary cells: incentives, status and perspectives

Authors: Kaas, Christian Schrøder; Fan, Yuzhou; Weilguny, Dietmar; Kristensen, Claus; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/6067dd57-c31e-41f2-9225-4c51754db14a

Thesis From omics to cellular mechanisms in mammalian cell factory development

Samoudi, Mojtaba; Masson, Helen O.; Kuo, Chih Chung et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: From omics to cellular mechanisms in mammalian cell factory development

Authors: Samoudi, Mojtaba; Masson, Helen O.; Kuo, Chih Chung; Robinson, Caressa M.; Lewis, Nathan E.

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5c3710d3-ef35-45bb-8010-f9ba8c882f04

Thesis Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process

Calmels, Cyrielle; McCann, Andréa; Malphettes, Laetitia et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process

Authors: Calmels, Cyrielle; McCann, Andréa; Malphettes, Laetitia; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/59c3f8ac-571d-4312-969f-4d6d5689e961

Thesis Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome.

Lewis, Nathan E; Liu, Xin; Li, Yuxiang et al. · 2013 · Technical University of Denmark (DTU) · DOI

Full title: Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome.

Authors: Lewis, Nathan E; Liu, Xin; Li, Yuxiang; Nagarajan, Harish; Yerganian, George; O'Brien, Edward; Bordbar, Aarash; Roth, Anne M; Rosenbloom, Jeffrey; Bian, Chao; Xie, Min; Chen, Wenbin; Li, Ning; Baycin-Hizal, Deniz; Latif, Haythem; Förster, Jochen; id_orcid 0000-0003-4045-7905; Betenbaugh, Michael; Famili, Iman; Xu, Xun; Wang, Jun; Palsson, Bernhard O; id_orcid 0000-0003-2357-6785

Year: 2013

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5e57cd4b-b567-4bee-9ea3-264e08ac9905

Thesis Development of a VHH-Based Erythropoietin Quantification Assay

Kol, Stefan; Beuchert Kallehauge, Thomas; Adema, Simon et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Development of a VHH-Based Erythropoietin Quantification Assay

Authors: Kol, Stefan; Beuchert Kallehauge, Thomas; Adema, Simon; Hermans, Pim

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/852e0d29-63c5-4251-b2b1-d053b4317987

Thesis Following an Optimal Batch Bioreactor Operations Model

Ibarra-Junquera, V.; Jørgensen, Sten Bay; id_orcid 0000-0002-3179-972X et al. · 2012 · Technical University of Denmark (DTU) · DOI

Full title: Following an Optimal Batch Bioreactor Operations Model

Authors: Ibarra-Junquera, V.; Jørgensen, Sten Bay; id_orcid 0000-0002-3179-972X; Virgen-Ortíz, J.J.; Escalante-Minakata, P.; Osuna-Castro, J.A.

Year: 2012

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7578e107-7ee3-4ba3-b03b-a7507ad16c8a

Thesis Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications

MacDonald, Michael A.; Nöbel, Matthias; Roche Recinos, Dinora et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications

Authors: MacDonald, Michael A.; Nöbel, Matthias; Roche Recinos, Dinora; Martínez, Verónica S.; Schulz, Benjamin L.; Howard, Christopher B.; Baker, Kym; Shave, Evan; Lee, Yih Yean; Marcellin, Esteban; Mahler, Stephen; Nielsen, Lars Keld; Munro, Trent

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/67f5a323-1367-4520-928b-e7b232c33cee

Thesis Multicopy Targeted Integration for Accelerated Development of High-Producing Chinese Hamster Ovary Cells

Sergeeva, Daria; Min Lee, Gyun; Nielsen, Lars Keld et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Multicopy Targeted Integration for Accelerated Development of High-Producing Chinese Hamster Ovary Cells

Authors: Sergeeva, Daria; Min Lee, Gyun; Nielsen, Lars Keld; Grav, Lise Marie; id_orcid 0000-0001-8042-7108

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/71c01a2d-bfaf-4f2b-a221-1ef2dd777ca7

Thesis Classification and Characterization of CHO Cell Lines on the Basis of Transcriptomic Signatures

Singh, Ankita · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Classification and Characterization of CHO Cell Lines on the Basis of Transcriptomic Signatures

Authors: Singh, Ankita

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7c151fcf-538a-4ac4-ad33-c5b284e7ed86

Thesis Using titer and titer normalized to confluence are complementary strategies for obtaining Chinese hamster ovary cell lines with high volumetric productivity of etanercept

Pristovšek, Nuša; Hansen, Henning Gram; Sergeeva, Daria et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Using titer and titer normalized to confluence are complementary strategies for obtaining Chinese hamster ovary cell lines with high volumetric productivity of etanercept

Authors: Pristovšek, Nuša; Hansen, Henning Gram; Sergeeva, Daria; Borth, Nicole; Min Lee, Gyun; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/72821a9b-dd89-40a8-a86e-7f920a10d4ea

Thesis A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering

Liang, Chenguang; Chiang, Austin W. T.; Hansen, Anders H. et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering

Authors: Liang, Chenguang; Chiang, Austin W. T.; Hansen, Anders H.; id_orcid 0000-0002-6007-4787; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Schoffelen, Sanne; id_orcid 0000-0003-2664-8561; Sorrentino, James T.; Kellman, Benjamin P.; Bao, Bokan; Voldborg, Bjørn G.; id_orcid 0000-0002-7005-1642; Lewis, Nathan E.

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/74da1088-d9ca-45bb-bcfb-73e554d9af88

Thesis Multi-omic profiling of EPO producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Multi-omic profiling of EPO producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Authors: Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael; Magdenoska, Olivera; Nielsen, Kristian Fog; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/87a5064f-e2fc-4741-b45c-4def9fbd8a82

Thesis Engineering nutrient and by-product metabolism of CHO cells

Domingues Pereira, Sara Isabel · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Engineering nutrient and by-product metabolism of CHO cells

Authors: Domingues Pereira, Sara Isabel

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/83ef725c-686f-4082-b2ee-cb9e812b6883

Thesis Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation

Nöbel, Matthias; Barry, Craig; MacDonald, Michael A. et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation

Authors: Nöbel, Matthias; Barry, Craig; MacDonald, Michael A.; Baker, Kym; Shave, Evan; Mahler, Stephen; Munro, Trent; Martínez, Verónica S.; Nielsen, Lars K.; Marcellin, Esteban

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7922b2bb-f311-4387-b752-e3faec2f9792

Thesis Dynamics of immature mAb glycoform secretion during CHO cell culture:An integrated modelling framework

Jimenez del Val, Ioscani; Fan, Yuzhou; Weilguny, Dietmar · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Dynamics of immature mAb glycoform secretion during CHO cell culture:An integrated modelling framework

Authors: Jimenez del Val, Ioscani; Fan, Yuzhou; Weilguny, Dietmar

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/72c9b07b-bd9a-42e9-a3f7-c0b8ae0aedf6

Thesis Accelerating Genome Editing in CHO Cells Using CRISPR Cas9 and CRISPy, a Web-Based Target Finding Tool

Ronda, Carlotta; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: Accelerating Genome Editing in CHO Cells Using CRISPR Cas9 and CRISPy, a Web-Based Target Finding Tool

Authors: Ronda, Carlotta; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Hansen, Henning Gram; Beuchert Kallehauge, Thomas; Betenbaugh, Michael; Nielsen, Alex Toftgaard; Kildegaard, Helene Faustrup

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/83aa80e2-8128-4c3f-a2a8-b38be50b53ab

Thesis Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

Fan, Yuzhou; Jimenez Del Val, Ioscani; Müller, Christian et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

Authors: Fan, Yuzhou; Jimenez Del Val, Ioscani; Müller, Christian; Wagtberg Sen, Jette; Rasmussen, Søren Kofoed; Kontoravdi, Cleo; Weilguny, Dietmar; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7390e534-3558-4a15-a8c1-359cc5555270

Thesis BCAT1 and BCAT2 disruption in CHO cells has cell line-dependent effects

Pereira, Sara; Ley, Daniel; Schubert, Mikkel et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: BCAT1 and BCAT2 disruption in CHO cells has cell line-dependent effects

Authors: Pereira, Sara; Ley, Daniel; Schubert, Mikkel; Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7faa5a66-7114-41e8-a5cc-88f11ee0bba3

Thesis Methods for modeling chinese hamster ovary (cho) cell metabolism.

Herrgard, Markus; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Methods for modeling chinese hamster ovary (cho) cell metabolism.

Authors: Herrgard, Markus; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Lewis, Nathan E.; Bruntse, Anders Bech

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/8529ad64-19cf-4add-99cf-9bf74dc64238

Thesis Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells

Pérez-Rodriguez, Saumel; Wulff, Tune; Voldborg, Bjørn G et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells

Authors: Pérez-Rodriguez, Saumel; Wulff, Tune; Voldborg, Bjørn G; id_orcid 0000-0002-7005-1642; Altamirano, Claudia; Trujillo-Roldán, Mauricio A; Valdez-Cruz, Norma A

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7e0744e3-e93e-4664-9482-32419e18ecac

Thesis Process analytical technology (PAT) for biopharmaceuticals

Glassey, Jarka; Gernaey, Krist; id_orcid 0000-0002-0364-1773 et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: Process analytical technology (PAT) for biopharmaceuticals

Authors: Glassey, Jarka; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Clemens, Christoph; Schulz, Torsten W.; Oliveira, Rui; Striedner, Gerald; Mandenius, Carl-Fredrik

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/88d90c02-087c-4518-9755-d49fd4b0cabd

Thesis Why is batch processing still dominating the biologics landscape? Towards an integrated continuous bioprocessing alternative

Kumar, Ashish; Udugama, Isuru A.; Gargalo, Carina L. et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Why is batch processing still dominating the biologics landscape? Towards an integrated continuous bioprocessing alternative

Authors: Kumar, Ashish; Udugama, Isuru A.; Gargalo, Carina L.; id_orcid 0000-0002-8740-9591; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7f1d4f70-3946-4a73-8809-241bc136ce8c

Thesis Lactate reduction in CHO cell cultures through metabolic analysis

Monge, Ivan Martinez; Hefzi, Hooman; Sanchez, Pere Comas et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Lactate reduction in CHO cell cultures through metabolic analysis

Authors: Monge, Ivan Martinez; Hefzi, Hooman; Sanchez, Pere Comas; Marín de Mas, Igor Batolomé; Decker, Marianne; Lecina, Martí; Cairó, Jordi Joan; Lewis, Nathan; Nielsen, Lars Keld

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/88a705b5-5f0e-40b9-b8ca-455e124be964

Thesis Accelerated and Rational Design of Improved CHO Cell Factories

Grav, Lise Marie; id_orcid 0000-0001-8042-7108 · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Accelerated and Rational Design of Improved CHO Cell Factories

Authors: Grav, Lise Marie; id_orcid 0000-0001-8042-7108

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a3024744-4f4a-4692-855c-e76aad3c77fc

Thesis RNA-Seq Highlights High Clonal Variation in Monoclonal Antibody Producing CHO Cells

Orellana, Camila A.; Marcellin, Esteban; Palfreyman, Robin W. et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: RNA-Seq Highlights High Clonal Variation in Monoclonal Antibody Producing CHO Cells

Authors: Orellana, Camila A.; Marcellin, Esteban; Palfreyman, Robin W.; Munro, Trent P.; Gray, Peter P.; Nielsen, Lars K.

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9c163db5-1757-4d8d-b0ec-6ea8bdfdf885

Thesis Deep sequencing reveals different compositions of mRNA transcribed from the F8 gene in a panel of FVIII-producing CHO cell lines

Kaas, Christian Schrøder; Bolt, Gert; Hansen, Jens J et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Deep sequencing reveals different compositions of mRNA transcribed from the F8 gene in a panel of FVIII-producing CHO cell lines

Authors: Kaas, Christian Schrøder; Bolt, Gert; Hansen, Jens J; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kristensen, Claus

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9c8c6758-0da6-42f9-bbd4-a8b4230291b9

Thesis Quantitative feature extraction from the Chinese hamster ovary bioprocess bibliome using a novel meta-analysis workflow

Golabgir, Aydin; Gutierrez, Jahir M.; Hefzi, Hooman et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Quantitative feature extraction from the Chinese hamster ovary bioprocess bibliome using a novel meta-analysis workflow

Authors: Golabgir, Aydin; Gutierrez, Jahir M.; Hefzi, Hooman; Li, Shangzhong; Palsson, Bernhard; id_orcid 0000-0003-2357-6785; Herwig, Christoph; Lewis, Nathan

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/8c007ce6-63c9-424a-85ac-4bab6a21e5f7

Thesis Dynamic Optimization for Monoclonal Antibody Production

Kaysfeld, Morten Wahlgreen; Kumar, Deepak; Nielsen, Marcus Krogh et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Dynamic Optimization for Monoclonal Antibody Production

Authors: Kaysfeld, Morten Wahlgreen; Kumar, Deepak; Nielsen, Marcus Krogh; Jørgensen, John Bagterp; id_orcid 0000-0001-9799-2808

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9ff2d615-438b-414d-a0e2-29da79c7a72c

Thesis Bioprocess facility for test of Engineered CHO cell lines in Single-use bioreactors

Decker, Marianne; Lund Jensen, Kristian; Javidi, Elham Maria et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Bioprocess facility for test of Engineered CHO cell lines in Single-use bioreactors

Authors: Decker, Marianne; Lund Jensen, Kristian; Javidi, Elham Maria; Voldborg, Bjørn Gunnar; id_orcid 0000-0002-7005-1642

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/99b1c9d0-42ef-4cee-b68e-d45bbaae761d

Thesis Mixing four Cell lines to produce an Antibody cocktail as a Next-generation antivenom - a Case study with a “mixed” Outcome

Christina Adams, Anna · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Mixing four Cell lines to produce an Antibody cocktail as a Next-generation antivenom - a Case study with a “mixed” Outcome

Authors: Christina Adams, Anna

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9b2942d6-7767-4e89-848f-d85b5d4dc44f

Thesis New developments in online OUR monitoring and its application to animal cell cultures

Martínez-Monge, I; Roman, R.; Comas, P. et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: New developments in online OUR monitoring and its application to animal cell cultures

Authors: Martínez-Monge, I; Roman, R.; Comas, P.; Fontova, A.; Lecina, M.; Casablancas, A.; Cairó, J J

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/8986a5a2-6603-4730-bb85-0c9865f51e7b

Thesis CHOmics:A web-based tool for multi-omics data analysis and interactive visualization in CHO cell lines

Lin, Dongdong; Yalamanchili, Hima B.; Zhang, Xinmin et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: CHOmics:A web-based tool for multi-omics data analysis and interactive visualization in CHO cell lines

Authors: Lin, Dongdong; Yalamanchili, Hima B.; Zhang, Xinmin; Lewis, Nathan E.; Alves, Christina S.; Groot, Joost; Arnsdorf, Johnny; id_orcid 0000-0002-2738-0811; Bjørn, Sara P.; id_orcid 0000-0003-3341-6160; Wulff, Tune; Voldborg, Bjørn G.; id_orcid 0000-0002-7005-1642; Zhou, Yizhou; Zhang, Baohong

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9e317d9d-c2fd-470d-b8fc-a27d29192c9b

Thesis Elucidation of the CHO Super-Ome (CHO-SO) by Proteoinformatics

Kumar, Amit; Baycin-Hizal, Deniz; Wolozny, Daniel et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Elucidation of the CHO Super-Ome (CHO-SO) by Proteoinformatics

Authors: Kumar, Amit; Baycin-Hizal, Deniz; Wolozny, Daniel; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Lewis, Nathan; Heffner, Kelley; Chaerkady, Raghothama; Cole, Robert N.; Shiloach, Joseph; Zhang, Hui; Bowen, Michael A.; Betenbaugh, Michael J.

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9d841c9b-1302-4b62-b81d-5087d0e2af07

Thesis N-Glycan analysis and engineering

Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787 · 2019 · Technical University of Denmark (DTU) · DOI

Full title: N-Glycan analysis and engineering

Authors: Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/abbd63ce-ce1d-455f-804f-20b718c3f892

Thesis One-step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment.

Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lee, Jae Seong et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: One-step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment.

Authors: Grav, Lise Marie; id_orcid 0000-0001-8042-7108; Lee, Jae Seong; Thomsen, Signe Gerling; Beuchert Kallehauge, Thomas; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Min Lee, Gyun; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Kildegaard, Helene Faustrup

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b3efc1f4-1970-4875-9462-c26194b49667

Thesis Developing tools for rational engineering of the secretory pathway in CHO cells

Rojek, Johan Blatt · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Developing tools for rational engineering of the secretory pathway in CHO cells

Authors: Rojek, Johan Blatt

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9dbfc2d8-4ee1-456f-9618-91c7ffe7c490

Thesis Direct quality control of glycoengineered erythropoietin variants

Čaval, Tomislav; Tian, Weihua; Yang, Zhang et al. · 2018 · University of Copenhagen · DOI

Full title: Direct quality control of glycoengineered erythropoietin variants

Authors: Čaval, Tomislav; Tian, Weihua; Yang, Zhang; Clausen, Henrik; Heck, Albert J.R.

Year: 2018

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/9ed5fa5c-46e4-4485-8d42-2454f8bedb5f

Thesis ‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells

Orellana, Camila A.; Martínez, Verónica S.; MacDonald, Michael A. et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: ‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells

Authors: Orellana, Camila A.; Martínez, Verónica S.; MacDonald, Michael A.; Henry, Matthew N.; Gillard, Marianne; Gray, Peter P.; Nielsen, Lars K.; Mahler, Stephen; Marcellin, Esteban

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/acf785a5-65ae-4eae-bd29-e37f42319ac1

Thesis Multi-omic profiling of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Multi-omic profiling of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Authors: Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael; Magdenoska, Olivera; Nielsen, Kristian Fog; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b2905a68-9052-41ca-b6f7-6cb30d6b56c5

Thesis Increased mAb production in amplified CHO cell lines is associated with increased interaction of CREB1 with transgene promoter

Dahodwala, Hussain; Kaushik, Prashant; Tejwani, Vijay et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Increased mAb production in amplified CHO cell lines is associated with increased interaction of CREB1 with transgene promoter

Authors: Dahodwala, Hussain; Kaushik, Prashant; Tejwani, Vijay; Chung Kuo, Chih; Ménard, Patrice; Henry, Michael; Voldborg, Bjørn G.; id_orcid 0000-0002-7005-1642; Lewis, Nathan E.; Meleady, Paula; Sharfstein, Susan T.

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ad0715a7-895d-4736-8553-188b40a57fe4

Thesis Modeling and Simulation of Upstream and Downstream Processes for Monoclonal Antibody Production

Wahlgreen, Morten Ryberg; Meyer, Kristian; Ritschel, Tobias K.S. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Modeling and Simulation of Upstream and Downstream Processes for Monoclonal Antibody Production

Authors: Wahlgreen, Morten Ryberg; Meyer, Kristian; Ritschel, Tobias K.S.; id_orcid 0000-0002-5843-240X; Engsig-Karup, Allan Peter; id_orcid 0000-0001-8626-1575; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773; Jørgensen, John Bagterp; id_orcid 0000-0001-9799-2808

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bee80c6c-737f-485c-a10c-8b202794086b

Thesis Development of dynamic compartment models for industrial aerobic fed-batch fermentation processes

Nadal-Rey, Gisela; McClure, Dale D.; Kavanagh, John M. et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Development of dynamic compartment models for industrial aerobic fed-batch fermentation processes

Authors: Nadal-Rey, Gisela; McClure, Dale D.; Kavanagh, John M.; Cassells, Benny; Cornelissen, Sjef; Fletcher, David F.; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b13c2130-8a91-421a-9095-93064cac393c

Thesis Comparison of spectroscopy technologies for improved monitoring of cell culture processes in miniature bioreactors

Rowland-Jones, Ruth C.; van der Berg, Franciscus Winfried J; Racher, Andrew J. et al. · 2017 · University of Copenhagen · DOI

Full title: Comparison of spectroscopy technologies for improved monitoring of cell culture processes in miniature bioreactors

Authors: Rowland-Jones, Ruth C.; van der Berg, Franciscus Winfried J; Racher, Andrew J.; Martin, Elaine B.; Jaques, Colin

Year: 2017

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/b0ba0d28-f1e5-4abb-be69-231b4094c928

Thesis Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity

Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity

Authors: Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Kildegaard, Helene Faustrup; Min Lee, Gyun

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b93398cc-7060-452d-87ce-fc9c3bf95dd0

Thesis Biopharmaceutical Process – Contract Development Organization: Startup

Chaffkin, Andrew; Headberg, Melissa; Jacobovitz, Louise et al. · 2023 · University of Pennsylvania · DOI

Full title: Biopharmaceutical Process – Contract Development Organization: Startup

Authors: Chaffkin, Andrew; Headberg, Melissa; Jacobovitz, Louise; Louie, Matthew

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/5964

Thesis The effect of in vitro culture conditions on cell metabolism

Hartley, F · 2018 · University of Oxford - ORA · DOI

Full title: The effect of in vitro culture conditions on cell metabolism

Authors: Hartley, F

Year: 2018

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:160ef4ac-b599-49db-97dc-f820b5cdb61f

Thesis Trends and approaches in N-Glycosylation engineering in Chinese hamster ovary cell culture

Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Trends and approaches in N-Glycosylation engineering in Chinese hamster ovary cell culture

Authors: Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1218be93-6eab-4722-851d-4378a47b79ee

Thesis Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production

Henry, Matthew N.; MacDonald, Michael A.; Orellana, Camila A. et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production

Authors: Henry, Matthew N.; MacDonald, Michael A.; Orellana, Camila A.; Gray, Peter P.; Gillard, Marianne; Baker, Kym; Nielsen, Lars K.; Marcellin, Esteban; Mahler, Stephen; Martínez, Verónica S.

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1326a05c-2af7-46f4-95fd-090bc436b967

Thesis N-Glycosylation optimization of recombinant antibodies in CHO cell through process and metabolic engineering

Fan, Yuzhou · 2015 · Technical University of Denmark (DTU) · DOI

Full title: N-Glycosylation optimization of recombinant antibodies in CHO cell through process and metabolic engineering

Authors: Fan, Yuzhou

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0d46b1c0-0617-4c4e-8295-079e1eddaf3e

Thesis A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

Fan, Yuzhou; Jimenez Del Val, Ioscani; Müller, Christian et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/032ff7ec-9b40-4a61-8f15-f7c40fa6a14e

Thesis Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers

Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers

Authors: Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem; Malphettes, Laetitia; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/07c1b78f-8e1b-4264-8b5a-d74f261ebab9

Thesis Trends and approaches in N-Glycosylation engineering in Chinese hamster ovary cell culture

Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Trends and approaches in N-Glycosylation engineering in Chinese hamster ovary cell culture

Authors: Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/05f81555-5e37-4d88-be11-678eda3ec16b

Thesis Single-Batch Expression of an Experimental Recombinant Snakebite Antivenom Based on an Oligoclonal Mixture of Human Monoclonal Antibodies

Adams, Anna C.; Grav, Lise M.; id_orcid 0000-0001-8042-7108 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Single-Batch Expression of an Experimental Recombinant Snakebite Antivenom Based on an Oligoclonal Mixture of Human Monoclonal Antibodies

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1cacecb6-2d02-484b-8855-606d116d8855

Thesis Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells

Saghaleyni, Rasool; Malm, Magdalena; Moruzzi, Noah et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2d7082ac-461c-4bfd-9506-aee94ce2430e

Thesis A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells

Schmieder, Valerie; Novak, Neža; Dhiman, Heena et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells

Authors: Schmieder, Valerie; Novak, Neža; Dhiman, Heena; Nguyen, Ly Ngoc; Serafimova, Evgenija; Klanert, Gerald; Baumann, Martina; Kildegaard, Helene Faustrup; Borth, Nicole

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2952ac8e-767c-4605-811b-710e6cd4ba19

Thesis Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing

Lee, Jae Seong; Park, Jin Hyoung; Kwang Ha, Tae et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/0ae89c9f-9a27-4554-a9b0-2af9aa0614a9

Thesis Glycoengineering in CHO cells: Advances in systems biology

Tejwani, Vijay; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808 et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Glycoengineering in CHO cells: Advances in systems biology

Authors: Tejwani, Vijay; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Nam, Jong Hyun; Sharfstein, Susan T

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/18d1eb12-342d-4d7e-bfaa-aad1a918cc13

Thesis CHO On A Detox: Removing By-Product Formation Through Cell Engineering

Pereira, Sara; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: CHO On A Detox: Removing By-Product Formation Through Cell Engineering

Authors: Pereira, Sara; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/16746af6-dbf5-46ee-a6a0-d5c8bf3c3b88

Thesis Method for reducing ammonium and lactate production in cho cells

Ley, Daniel; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808 et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Method for reducing ammonium and lactate production in cho cells

Authors: Ley, Daniel; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2eca9af1-d5e3-427f-a8d4-142c07400b20

Thesis A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism

Hefzi, Hooman; Ang, Kok Siong; Hanscho, Michael et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2f8bb3cd-eb0c-46f7-b39b-3791d7c86d1d

Thesis Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process

Calmels, Cyrielle; McCann, Andréa; Malphettes, Laetitia et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process

Authors: Calmels, Cyrielle; McCann, Andréa; Malphettes, Laetitia; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/59c3f8ac-571d-4312-969f-4d6d5689e961

Thesis Cell culture process dynamics and metabolic flux distributions using hybrid models

Kailasanathan, Rajiv; Sivaram, Abhishek; Mansouri, Seyed Soheil et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Cell culture process dynamics and metabolic flux distributions using hybrid models

Authors: Kailasanathan, Rajiv; Sivaram, Abhishek; Mansouri, Seyed Soheil; id_orcid 0000-0002-0924-4947

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/572e7d61-3351-4ced-b2f5-6b9e4ceab22f

Thesis Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

Pereira, Sara; Kildegaard, Helene F.; Andersen, Mikael R. et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

Authors: Pereira, Sara; Kildegaard, Helene F.; Andersen, Mikael R.; id_orcid 0000-0003-4794-6808

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/28b6ee0a-2f57-47f3-ba14-6a113e9c7800

Thesis Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Hansen, Henning Gram; Nilsson, Claes Nymand; Lund, Anne Mathilde et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/41719bc3-f624-40be-ba5e-4449c22aac7f

Thesis Deciphering Cytokine production in CHO cells by Integrating Cell Line Engineering and Omics Strategies

Scapin, Giulia; id_orcid 0000-0002-2978-9549 · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Deciphering Cytokine production in CHO cells by Integrating Cell Line Engineering and Omics Strategies

Authors: Scapin, Giulia; id_orcid 0000-0002-2978-9549

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4d3f74ae-375a-4103-9968-3b362af8aa22

Thesis BiP Inducer X: An ER Stress Inhibitor for Enhancing Recombinant Antibody Production in CHO Cell Culture

Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders H et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: BiP Inducer X: An ER Stress Inhibitor for Enhancing Recombinant Antibody Production in CHO Cell Culture

Authors: Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders H; id_orcid 0000-0002-6007-4787; Kildegaard, Helene Faustrup; Min Lee, Gyun

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4bb8049c-8448-48b2-849a-893bbcc3e831

Thesis A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

Lund, Anne Mathilde; Kildegaard, Helene Faustrup; Petersen, Maja Borup Kjær et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1e6b9cdd-536a-420a-b808-622781069950

Thesis Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Martínez-Monge, I.; Martínez, C.; Decker, M. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Authors: Martínez-Monge, I.; Martínez, C.; Decker, M.; Udugama, I. A.; Marín de Mas, I.; Gernaey, K. V.; id_orcid 0000-0002-0364-1773; Nielsen, L. K.

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3b1685d4-5ab9-4737-b414-d28fecf9b9eb

Thesis A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering

Liang, Chenguang; Chiang, Austin W. T.; Hansen, Anders H. et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/74da1088-d9ca-45bb-bcfb-73e554d9af88

Thesis The GalNAc-type O-Glycoproteome of CHO Cells Characterized by the SimpleCell Strategy

Zhang, Yang; Halim, Adnan; Narimatsu, Yoshiki et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: The GalNAc-type O-Glycoproteome of CHO Cells Characterized by the SimpleCell Strategy

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5ebfd0ee-130e-4389-ae10-57be9960dab0

Thesis Multicopy Targeted Integration for Accelerated Development of High-Producing Chinese Hamster Ovary Cells

Sergeeva, Daria; Min Lee, Gyun; Nielsen, Lars Keld et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Multicopy Targeted Integration for Accelerated Development of High-Producing Chinese Hamster Ovary Cells

Authors: Sergeeva, Daria; Min Lee, Gyun; Nielsen, Lars Keld; Grav, Lise Marie; id_orcid 0000-0001-8042-7108

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/71c01a2d-bfaf-4f2b-a221-1ef2dd777ca7

Thesis Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome.

Lewis, Nathan E; Liu, Xin; Li, Yuxiang et al. · 2013 · Technical University of Denmark (DTU) · DOI

Full title: Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome.

Year: 2013

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5e57cd4b-b567-4bee-9ea3-264e08ac9905

Thesis Data-Driven Cell Engineering of Chinese Hamster Ovary Cells through Machine Learning

Zaragoza, Jose Manuel Camacho · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Data-Driven Cell Engineering of Chinese Hamster Ovary Cells through Machine Learning

Authors: Zaragoza, Jose Manuel Camacho

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/5ba1a67a-d916-46d2-be02-2dcbaa66a091

Thesis Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells

Pérez-Rodriguez, Saumel; Wulff, Tune; Voldborg, Bjørn G et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells

Authors: Pérez-Rodriguez, Saumel; Wulff, Tune; Voldborg, Bjørn G; id_orcid 0000-0002-7005-1642; Altamirano, Claudia; Trujillo-Roldán, Mauricio A; Valdez-Cruz, Norma A

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7e0744e3-e93e-4664-9482-32419e18ecac

Thesis Impact of cellular stress on recombinant monoclonal antibody produced by high yielding Chinese Hamster Ovary (CHO) cell cultures in bioreactors

Chevallier, Valentine · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Impact of cellular stress on recombinant monoclonal antibody produced by high yielding Chinese Hamster Ovary (CHO) cell cultures in bioreactors

Authors: Chevallier, Valentine

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/563b6ddf-77b7-40a0-94d6-f435d6d8a1ca

Thesis Methods for modeling chinese hamster ovary (cho) cell metabolism.

Herrgard, Markus; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Methods for modeling chinese hamster ovary (cho) cell metabolism.

Authors: Herrgard, Markus; Pedersen, Lasse Ebdrup; id_orcid 0000-0002-6064-919X; Lewis, Nathan E.; Bruntse, Anders Bech

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/8529ad64-19cf-4add-99cf-9bf74dc64238

Thesis Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation

Nöbel, Matthias; Barry, Craig; MacDonald, Michael A. et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation

Authors: Nöbel, Matthias; Barry, Craig; MacDonald, Michael A.; Baker, Kym; Shave, Evan; Mahler, Stephen; Munro, Trent; Martínez, Verónica S.; Nielsen, Lars K.; Marcellin, Esteban

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7922b2bb-f311-4387-b752-e3faec2f9792

Thesis The cell density effect in animal cell-based bioprocessing:Questions, insights and perspectives

Lavado-García, Jesús; Pérez-Rubio, Pol; Cervera, Laura et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: The cell density effect in animal cell-based bioprocessing:Questions, insights and perspectives

Authors: Lavado-García, Jesús; Pérez-Rubio, Pol; Cervera, Laura; Gòdia, Francesc

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/59d319c9-b38b-40f6-a360-60ecc53c3457

Thesis Dynamics of immature mAb glycoform secretion during CHO cell culture:An integrated modelling framework

Jimenez del Val, Ioscani; Fan, Yuzhou; Weilguny, Dietmar · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Dynamics of immature mAb glycoform secretion during CHO cell culture:An integrated modelling framework

Authors: Jimenez del Val, Ioscani; Fan, Yuzhou; Weilguny, Dietmar

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/72c9b07b-bd9a-42e9-a3f7-c0b8ae0aedf6

Thesis Developing Tools for Improved and Predictable Recombinant Protein Production in CHO Cells

Pristovšek, Nuša · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Developing Tools for Improved and Predictable Recombinant Protein Production in CHO Cells

Authors: Pristovšek, Nuša

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/64616d27-ec57-4e4b-8166-fddb72ce82e5

Thesis Classification and Characterization of CHO Cell Lines on the Basis of Transcriptomic Signatures

Singh, Ankita · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Classification and Characterization of CHO Cell Lines on the Basis of Transcriptomic Signatures

Authors: Singh, Ankita

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7c151fcf-538a-4ac4-ad33-c5b284e7ed86

Thesis Expression of antibody fragments in Saccharomyces cerevisiae strains evolved for enhanced protein secretion

Wang, Yanyan; Li, Xiaowei; Chen, Xin et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Expression of antibody fragments in Saccharomyces cerevisiae strains evolved for enhanced protein secretion

Authors: Wang, Yanyan; Li, Xiaowei; Chen, Xin; Nielsen, Jens; Petranovic, Dina; Siewers, Verena

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7f70d6dd-3490-4db7-be9b-c8be2d8f8e8f

Thesis Engineering nutrient and by-product metabolism of CHO cells

Domingues Pereira, Sara Isabel · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Engineering nutrient and by-product metabolism of CHO cells

Authors: Domingues Pereira, Sara Isabel

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/83ef725c-686f-4082-b2ee-cb9e812b6883

Thesis Using titer and titer normalized to confluence are complementary strategies for obtaining Chinese hamster ovary cell lines with high volumetric productivity of etanercept

Pristovšek, Nuša; Hansen, Henning Gram; Sergeeva, Daria et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Using titer and titer normalized to confluence are complementary strategies for obtaining Chinese hamster ovary cell lines with high volumetric productivity of etanercept

Authors: Pristovšek, Nuša; Hansen, Henning Gram; Sergeeva, Daria; Borth, Nicole; Min Lee, Gyun; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/72821a9b-dd89-40a8-a86e-7f920a10d4ea

Thesis Process analytical technology (PAT) for biopharmaceuticals

Glassey, Jarka; Gernaey, Krist; id_orcid 0000-0002-0364-1773 et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: Process analytical technology (PAT) for biopharmaceuticals

Authors: Glassey, Jarka; Gernaey, Krist; id_orcid 0000-0002-0364-1773; Clemens, Christoph; Schulz, Torsten W.; Oliveira, Rui; Striedner, Gerald; Mandenius, Carl-Fredrik

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/88d90c02-087c-4518-9755-d49fd4b0cabd

Thesis CRISPR/Cas9-multiplexed editing of Chinese hamster ovary B4Gal-T1, 2, 3 and 4 Tailors N -Glycan Profiles of Therapeutics and Secreted Host Cell Proteins

Amann, Thomas; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787 et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: CRISPR/Cas9-multiplexed editing of Chinese hamster ovary B4Gal-T1, 2, 3 and 4 Tailors N -Glycan Profiles of Therapeutics and Secreted Host Cell Proteins

Authors: Amann, Thomas; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Min Lee, Gyun; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kildegaard, Helene Faustrup

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9615dda9-824f-44dc-945a-6dbf6dc22600

Thesis Development of a VHH-Based Erythropoietin Quantification Assay

Kol, Stefan; Beuchert Kallehauge, Thomas; Adema, Simon et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Development of a VHH-Based Erythropoietin Quantification Assay

Authors: Kol, Stefan; Beuchert Kallehauge, Thomas; Adema, Simon; Hermans, Pim

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/852e0d29-63c5-4251-b2b1-d053b4317987

Thesis Deep sequencing reveals different compositions of mRNA transcribed from the F8 gene in a panel of FVIII-producing CHO cell lines

Kaas, Christian Schrøder; Bolt, Gert; Hansen, Jens J et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Deep sequencing reveals different compositions of mRNA transcribed from the F8 gene in a panel of FVIII-producing CHO cell lines

Authors: Kaas, Christian Schrøder; Bolt, Gert; Hansen, Jens J; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Kristensen, Claus

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9c8c6758-0da6-42f9-bbd4-a8b4230291b9

Thesis Multi-omic profiling of EPO producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Multi-omic profiling of EPO producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Authors: Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael; Magdenoska, Olivera; Nielsen, Kristian Fog; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/87a5064f-e2fc-4741-b45c-4def9fbd8a82

Thesis Developing tools for rational engineering of the secretory pathway in CHO cells

Rojek, Johan Blatt · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Developing tools for rational engineering of the secretory pathway in CHO cells

Authors: Rojek, Johan Blatt

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9dbfc2d8-4ee1-456f-9618-91c7ffe7c490

Thesis Navigating biomanufacturing challenges in the use of CHO cells for recombinant adeno-associated virus production

Tatjer, David Catalán; id_orcid 0000-0002-0900-9912 · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Navigating biomanufacturing challenges in the use of CHO cells for recombinant adeno-associated virus production

Authors: Tatjer, David Catalán; id_orcid 0000-0002-0900-9912

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9209d5ce-66e5-452d-9d20-a94da77a0102

Thesis Dynamic Optimization for Monoclonal Antibody Production

Kaysfeld, Morten Wahlgreen; Kumar, Deepak; Nielsen, Marcus Krogh et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Dynamic Optimization for Monoclonal Antibody Production

Authors: Kaysfeld, Morten Wahlgreen; Kumar, Deepak; Nielsen, Marcus Krogh; Jørgensen, John Bagterp; id_orcid 0000-0001-9799-2808

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9ff2d615-438b-414d-a0e2-29da79c7a72c

Thesis Bioprocess facility for test of Engineered CHO cell lines in Single-use bioreactors

Decker, Marianne; Lund Jensen, Kristian; Javidi, Elham Maria et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Bioprocess facility for test of Engineered CHO cell lines in Single-use bioreactors

Authors: Decker, Marianne; Lund Jensen, Kristian; Javidi, Elham Maria; Voldborg, Bjørn Gunnar; id_orcid 0000-0002-7005-1642

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/99b1c9d0-42ef-4cee-b68e-d45bbaae761d

Thesis Accelerated and Rational Design of Improved CHO Cell Factories

Grav, Lise Marie; id_orcid 0000-0001-8042-7108 · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Accelerated and Rational Design of Improved CHO Cell Factories

Authors: Grav, Lise Marie; id_orcid 0000-0001-8042-7108

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a3024744-4f4a-4692-855c-e76aad3c77fc

Thesis Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

Noh, Soo Min; Shin, Seunghyeon; Min Lee, Gyun · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

Authors: Noh, Soo Min; Shin, Seunghyeon; Min Lee, Gyun

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c3748c8e-d76f-40e3-8fcb-c291becc3057

Thesis ‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells

Orellana, Camila A.; Martínez, Verónica S.; MacDonald, Michael A. et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: ‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells

Authors: Orellana, Camila A.; Martínez, Verónica S.; MacDonald, Michael A.; Henry, Matthew N.; Gillard, Marianne; Gray, Peter P.; Nielsen, Lars K.; Mahler, Stephen; Marcellin, Esteban

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/acf785a5-65ae-4eae-bd29-e37f42319ac1

Thesis Multi-omic profiling of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Multi-omic profiling of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Authors: Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael; Magdenoska, Olivera; Nielsen, Kristian Fog; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b2905a68-9052-41ca-b6f7-6cb30d6b56c5

Thesis Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity

Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity

Authors: Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Kildegaard, Helene Faustrup; Min Lee, Gyun

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b93398cc-7060-452d-87ce-fc9c3bf95dd0

Thesis CHOmics:A web-based tool for multi-omics data analysis and interactive visualization in CHO cell lines

Lin, Dongdong; Yalamanchili, Hima B.; Zhang, Xinmin et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: CHOmics:A web-based tool for multi-omics data analysis and interactive visualization in CHO cell lines

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9e317d9d-c2fd-470d-b8fc-a27d29192c9b

Thesis Model-based analysis of N-glycosylation in Chinese hamster ovary cells

Krambeck, Frederick J.; Bennun, Sandra V; Andersen, Mikael Rørdam et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Model-based analysis of N-glycosylation in Chinese hamster ovary cells

Authors: Krambeck, Frederick J.; Bennun, Sandra V; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Betenbaugh, Michael J.

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b07b66c3-9b3c-42d5-8350-78cf6f0092cb

Thesis N-Glycan analysis and engineering

Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787 · 2019 · Technical University of Denmark (DTU) · DOI

Full title: N-Glycan analysis and engineering

Authors: Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/abbd63ce-ce1d-455f-804f-20b718c3f892

Thesis Mixing four Cell lines to produce an Antibody cocktail as a Next-generation antivenom - a Case study with a “mixed” Outcome

Christina Adams, Anna · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Mixing four Cell lines to produce an Antibody cocktail as a Next-generation antivenom - a Case study with a “mixed” Outcome

Authors: Christina Adams, Anna

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9b2942d6-7767-4e89-848f-d85b5d4dc44f

Thesis Modeling and Simulation of Upstream and Downstream Processes for Monoclonal Antibody Production

Wahlgreen, Morten Ryberg; Meyer, Kristian; Ritschel, Tobias K.S. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Modeling and Simulation of Upstream and Downstream Processes for Monoclonal Antibody Production

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bee80c6c-737f-485c-a10c-8b202794086b

Thesis Multi-omic profiling of EPO-producing CHO cell panel reveals metabolic adaptation to heterologous protein production

Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Multi-omic profiling of EPO-producing CHO cell panel reveals metabolic adaptation to heterologous protein production

Authors: Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael; Magdenoska, Olivera; Nielsen, Kristian Fog; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ae3826c0-e867-44cc-af52-550e11e0c5a4

Thesis Evaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration

Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Kumar Ganesan, Saravana et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Evaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration

Authors: Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Kumar Ganesan, Saravana; Martínez-Monje, Iván; Grav, Lise M.; id_orcid 0000-0001-8042-7108; Lavado-García, Jesús; Nielsen, Lars K.

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c72a6084-3783-4f79-b07b-6c0d4b2e6fdb

Thesis Increased mAb production in amplified CHO cell lines is associated with increased interaction of CREB1 with transgene promoter

Dahodwala, Hussain; Kaushik, Prashant; Tejwani, Vijay et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Increased mAb production in amplified CHO cell lines is associated with increased interaction of CREB1 with transgene promoter

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ad0715a7-895d-4736-8553-188b40a57fe4

Thesis Early-Stage In Silico Flowsheet Analysis for a Monoclonal Antibody Platform

Kaiser, Johann; id_orcid 0000-0002-1383-6531; Babi, Deenesh K. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Early-Stage In Silico Flowsheet Analysis for a Monoclonal Antibody Platform

Authors: Kaiser, Johann; id_orcid 0000-0002-1383-6531; Babi, Deenesh K.; Pinelo, Manuel; id_orcid 0000-0002-3944-6144; Krühne, Ulrich; id_orcid 0000-0001-7774-7442

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c3fbbf6b-2d0e-43ac-9387-8537778ebc8f

Thesis Expanding the CRISPR Toolbox for Chinese Hamster Ovary Cell Line Engineering

Julie la Cour Karottki, Karen · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Expanding the CRISPR Toolbox for Chinese Hamster Ovary Cell Line Engineering

Authors: Julie la Cour Karottki, Karen

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d08e2c40-059b-4d60-af81-5dcae6b7155e

Thesis Method of designing carbohydrates

Lewis, Nathan; Chiang, Wan-Tien; Liang, Chenguang · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Method of designing carbohydrates

Authors: Lewis, Nathan; Chiang, Wan-Tien; Liang, Chenguang

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ba83157b-c8c3-43b6-8fd5-c238aa8df054

Thesis Development of dynamic compartment models for industrial aerobic fed-batch fermentation processes

Nadal-Rey, Gisela; McClure, Dale D.; Kavanagh, John M. et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Development of dynamic compartment models for industrial aerobic fed-batch fermentation processes

Authors: Nadal-Rey, Gisela; McClure, Dale D.; Kavanagh, John M.; Cassells, Benny; Cornelissen, Sjef; Fletcher, David F.; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b13c2130-8a91-421a-9095-93064cac393c

Thesis Multiplex secretome engineering enhances recombinant protein production and purity

Kol, Stefan; Ley, Daniel; Wulff, Tune et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Multiplex secretome engineering enhances recombinant protein production and purity

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c440cd45-e242-4b63-9b03-861ba7d54bf2

Thesis Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions

Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions

Authors: Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup; Min Lee, Gyun

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d8293414-1d83-4cde-bd35-d5339a98b4f4

Thesis Engineering death resistance in CHO cells for improved perfusion culture

MacDonald, Michael A.; Nöbel, Matthias; Martínez, Verónica S. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Engineering death resistance in CHO cells for improved perfusion culture

Authors: MacDonald, Michael A.; Nöbel, Matthias; Martínez, Verónica S.; Baker, Kym; Shave, Evan; Gray, Peter P.; Mahler, Stephen; Munro, Trent; Nielsen, Lars K.; Marcellin, Esteban

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ce202b32-0a67-4570-a87a-ab0849f12696

Thesis Multi-omic profiling of EPO-producing CHO cell panel reveals metabolic adaptation to heterologous protein production

Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Multi-omic profiling of EPO-producing CHO cell panel reveals metabolic adaptation to heterologous protein production

Authors: Ley, Daniel; Kazemi Seresht, Ali; Engmark, Mikael; Magdenoska, Olivera; Nielsen, Kristian Fog; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d87f41ff-ed91-4f7b-bc8e-f9f6e581ebcb

Thesis Identifying Drivers of Downstream Yield Variability Using Integrated Process Models: An Application to API Manufacturing

Overgaard, Tobias; Bertran, Maria Ona; Jørgensen, John Bagterp et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Identifying Drivers of Downstream Yield Variability Using Integrated Process Models: An Application to API Manufacturing

Authors: Overgaard, Tobias; Bertran, Maria Ona; Jørgensen, John Bagterp; id_orcid 0000-0001-9799-2808; Nielsen, Bo Friis; id_orcid 0000-0001-9146-9733

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c4296fd2-3123-42e0-8e21-f09af0e5990b

Thesis Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion

Ley, Daniel; Pereira, Sara; Pedersen, Lasse Ebdrup et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e6e02b2a-1da9-46ca-ab3f-71e6a95e52f8

Thesis An Online Compendium of CHO RNA-Seq Data Allows Identification of CHO Cell Line-specific Transcriptomic Signatures

Singh, Ankita; Kildegaard, Helene F.; Andersen, Mikael R. et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: An Online Compendium of CHO RNA-Seq Data Allows Identification of CHO Cell Line-specific Transcriptomic Signatures

Authors: Singh, Ankita; Kildegaard, Helene F.; Andersen, Mikael R.; id_orcid 0000-0003-4794-6808

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bf556aa7-6180-46f6-8a4f-dd827e2311ac

Thesis CHO glyco-engineering using CRISPR/Cas9 multiplexing for protein production with homogeneous N-glycan profiles

Amann, Thomas; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787 et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: CHO glyco-engineering using CRISPR/Cas9 multiplexing for protein production with homogeneous N-glycan profiles

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c6d75303-ecfd-4e56-a505-e7c61e81da81

Thesis Design of Optimal CHO Protein N-glycosylation Profiles

Amann, Thomas · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Design of Optimal CHO Protein N-glycosylation Profiles

Authors: Amann, Thomas

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f56793d2-957c-4049-bb8d-1cb2253f60a3

Thesis Predictive glycoengineering of biosimilars using a Markov chain glycosylation model

Spahn, Philipp N.; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787 et al. · 2017 · Technical University of Denmark (DTU) · DOI

Full title: Predictive glycoengineering of biosimilars using a Markov chain glycosylation model

Authors: Spahn, Philipp N.; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Voldborg, Bjørn Gunnar; id_orcid 0000-0002-7005-1642; Lewis, Nathan E.

Year: 2017

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c81572eb-3d8b-4c44-b92d-952116fe851f

Thesis Bioprocess for testing engineered cho cell lines using single-use bioreactors

Decker, Marianne · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Bioprocess for testing engineered cho cell lines using single-use bioreactors

Authors: Decker, Marianne

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/dc4a0b9d-3f6c-410b-97ef-d0ede37e6c36

Thesis Targeted gene integration for improved production of therapeutic proteins in CHO cells

Sergeeva, Daria · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Targeted gene integration for improved production of therapeutic proteins in CHO cells

Authors: Sergeeva, Daria

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e5d1f7f4-51e8-4ccc-989e-2d60bf1b29d7

Thesis Customizing amino acid metabolism of Pichia pastoris for recombinant protein production

Rußmayer, Hannes; Buchetics, Markus; Mattanovich, Matthias et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Customizing amino acid metabolism of Pichia pastoris for recombinant protein production

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e65f1561-1cd7-495e-8db2-b64cc656c938

Thesis Glycoprofiling effects of media additives on IgG produced by CHO cells in fed-batch bioreactors

Kildegaard, Helene Faustrup; Fan, Yuzhou; Wagtberg Sen, Jette et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Glycoprofiling effects of media additives on IgG produced by CHO cells in fed-batch bioreactors

Authors: Kildegaard, Helene Faustrup; Fan, Yuzhou; Wagtberg Sen, Jette; Larsen, Bo; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/06580715-5855-4a31-b7d8-a2a4f0dff2c4

Thesis Modeling apoptosis resistance in CHO cells with CRISPR-mediated knockouts of Bak1, Bax, and Bok

MacDonald, Michael A.; Barry, Craig; Groves, Teddy et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Modeling apoptosis resistance in CHO cells with CRISPR-mediated knockouts of Bak1, Bax, and Bok

Authors: MacDonald, Michael A.; Barry, Craig; Groves, Teddy; Martínez, Verónica S.; Gray, Peter P.; Baker, Kym; Shave, Evan; Mahler, Stephen; Munro, Trent; Marcellin, Esteban; Nielsen, Lars K.

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/f471d371-7ef9-48ac-ad01-8f0de141966f

Thesis Combinatorial treatment with lithium chloride enhances recombinant antibody production in transiently transfected CHO and HEK293E cells

Kim, Che Lin; Kwang Ha, Tae; Min Lee, Gyun · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Combinatorial treatment with lithium chloride enhances recombinant antibody production in transiently transfected CHO and HEK293E cells

Authors: Kim, Che Lin; Kwang Ha, Tae; Min Lee, Gyun

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/01b5ec11-ab2c-410e-8ab0-629bf31319da

Thesis Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells

Chevallier, Valentine; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808 et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells

Authors: Chevallier, Valentine; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808; Malphettes, Laetitia

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ff089eb9-bd04-4d58-a66a-ada79e4b6341

Thesis Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers

Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers

Authors: Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem; Malphettes, Laetitia; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/07c1b78f-8e1b-4264-8b5a-d74f261ebab9

Thesis Network Reconstruction and In Silico Metabolic Model of Chinese Hamster Ovary cells

Calmels, Cyrielle · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Network Reconstruction and In Silico Metabolic Model of Chinese Hamster Ovary cells

Authors: Calmels, Cyrielle

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e8e79519-7089-44aa-9964-6700b9af9251

Thesis Trends and approaches in N-Glycosylation engineering in Chinese hamster ovary cell culture

Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Trends and approaches in N-Glycosylation engineering in Chinese hamster ovary cell culture

Authors: Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/05f81555-5e37-4d88-be11-678eda3ec16b

Thesis Trends and approaches in N-Glycosylation engineering in Chinese hamster ovary cell culture

Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Trends and approaches in N-Glycosylation engineering in Chinese hamster ovary cell culture

Authors: Fan, Yuzhou; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1218be93-6eab-4722-851d-4378a47b79ee

Thesis Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production

Henry, Matthew N.; MacDonald, Michael A.; Orellana, Camila A. et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production

Authors: Henry, Matthew N.; MacDonald, Michael A.; Orellana, Camila A.; Gray, Peter P.; Gillard, Marianne; Baker, Kym; Nielsen, Lars K.; Marcellin, Esteban; Mahler, Stephen; Martínez, Verónica S.

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1326a05c-2af7-46f4-95fd-090bc436b967

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Paper

Impact of Different Promoters on Episomal Vectors Harbouring Characteristic Motifs of Matrix Attachment Regions

Wang, Xiao-Yin; Zhang, Jun‐He; Zhang, Xi et al. · 2016

Full title: Impact of Different Promoters on Episomal Vectors Harbouring Characteristic Motifs of Matrix Attachment Regions

Authors: Wang, Xiao-Yin; Zhang, Jun‐He; Zhang, Xi; Sun, Qiu‐li; Zhao, Chun-Peng; Wang, Tianyun

DOI: https://doi.org/10.1038/srep26446

Paper

Matrix attachment region combinations increase transgene expression in transfected Chinese hamster ovary cells

Zhao, Chun‐Peng; Guo, Xiao; Chen, Si‐Jia et al. · 2017

Full title: Matrix attachment region combinations increase transgene expression in transfected Chinese hamster ovary cells

Authors: Zhao, Chun‐Peng; Guo, Xiao; Chen, Si‐Jia; Li, Changzheng; Yang, Yun; Zhang, Junhe; Chen, Shao-nan; Jia, Yan‐Long; Wang, Tianyun

DOI: https://doi.org/10.1038/srep42805

Paper

Analytical Characterization of Monoclonal Antibodies with Novel Fc Receptor-Based Chromatography Technique

A. Chakrabarti; J. Kervinen; E. Müller et al. · 2020

Full title: Analytical Characterization of Monoclonal Antibodies with Novel Fc Receptor-Based Chromatography Technique

Authors: A. Chakrabarti; J. Kervinen; E. Müller; Toru Tanaka; Kazuaki Muranaka

DOI: https://doi.org/10.5772/intechopen.95356

Paper

The impact of cell culture on medicine

Ying Chun Lu; Taohsueh Liao · 2024

Full title: The impact of cell culture on medicine

Authors: Ying Chun Lu; Taohsueh Liao

DOI: https://doi.org/10.54615/2231-7805.20169

Paper

Strategies for Glycoengineering Therapeutic Proteins

Dammen‐Brower, Kris; Epler, Paige; Zhu, Stanley et al. · 2022

Full title: Strategies for Glycoengineering Therapeutic Proteins

Authors: Dammen‐Brower, Kris; Epler, Paige; Zhu, Stanley; Bernstein, Zachary J.; Stabach, Paul R.; Braddock, Demetrios T.; Spangler, Jamie B.; Yarema, Kevin J.

DOI: https://doi.org/10.3389/fchem.2022.863118

Paper

Recent Developments in Bioprocessing of Recombinant Proteins: Expression Hosts and Process Development

Tripathi, Nagesh K.; Shrivastava, Ambuj · 2019

Full title: Recent Developments in Bioprocessing of Recombinant Proteins: Expression Hosts and Process Development

Authors: Tripathi, Nagesh K.; Shrivastava, Ambuj

DOI: https://doi.org/10.3389/fbioe.2019.00420

Paper

Expression of Recombinant Antibodies

Frenzel, André; Hust, Michael; Schirrmann, Thomas · 2013

Full title: Expression of Recombinant Antibodies

Authors: Frenzel, André; Hust, Michael; Schirrmann, Thomas

DOI: https://doi.org/10.3389/fimmu.2013.00217

Paper

Improving Immunotherapy Through Glycodesign

Buettner, Matthew J.; Shah, Sagar; Saeui, Christopher T. et al. · 2018

Full title: Improving Immunotherapy Through Glycodesign

Authors: Buettner, Matthew J.; Shah, Sagar; Saeui, Christopher T.; Ariss, Ryan; Yarema, Kevin J.

DOI: https://doi.org/10.3389/fimmu.2018.02485

Thesis

Development of a novel bioreactor and systems for suspension cell culture in biopharmaceutical production

Sharma, Rajesh · 2022

Full title: Development of a novel bioreactor and systems for suspension cell culture in biopharmaceutical production

Authors: Sharma, Rajesh

DOI: http://hdl.handle.net/11427/36112

Thesis

Sobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes

Bulté Ocaña, Dubhe Beatriz · 2021

Full title: Sobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes

Authors: Bulté Ocaña, Dubhe Beatriz

DOI: https://hdl.handle.net/20.500.14330/TES01000806237

Thesis

Improving protein yield from mammalian cells by manipulation of stress response pathways

Chalmers, Fiona · 2016

Full title: Improving protein yield from mammalian cells by manipulation of stress response pathways

Authors: Chalmers, Fiona

DOI: https://theses.gla.ac.uk/7666/7/2016ChalmersPhD.pdf

Thesis

Impact de la modification du métabolisme primaire des cellules CHO sur leur productivité

Toussaint, Cecile · 2017

Full title: Impact de la modification du métabolisme primaire des cellules CHO sur leur productivité

Authors: Toussaint, Cecile

DOI: http://hdl.handle.net/1866/18549

Thesis

Recombinant protein production utilising a metallothionein expression system and a Super-CHO cell line

Huang, Edwin P.C. · 2006

Full title: Recombinant protein production utilising a metallothionein expression system and a Super-CHO cell line

Authors: Huang, Edwin P.C.

DOI: http://hdl.handle.net/1959.4/24940

Thesis

Transient production of biopharmaceutical proteins

Wei, Tzu-Hsiang · 2009

Full title: Transient production of biopharmaceutical proteins

Authors: Wei, Tzu-Hsiang

DOI: http://hdl.handle.net/1959.4/43708

Thesis

Effects of imperfect mixing in suspended plant and animal cell cultures

Cheung, Caleb Kin Lok · 2006

Full title: Effects of imperfect mixing in suspended plant and animal cell cultures

Authors: Cheung, Caleb Kin Lok

DOI: http://hdl.handle.net/1959.4/25200

Thesis

The Biological Impact of High Throughput Continuous Bioprocessing

Sewell, David John · 2020

Full title: The Biological Impact of High Throughput Continuous Bioprocessing

Authors: Sewell, David John

DOI: https://www.repository.cam.ac.uk/handle/1810/311711

Thesis

Appendix for: "Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch"

Gangadharan, Nishanthi · 2023

Full title: Appendix for: "Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch"

Authors: Gangadharan, Nishanthi

DOI: https://www.repository.cam.ac.uk/handle/1810/347248

Thesis

A study of apoptosis and cell cycle to augment transfection efficiency in CHO cell lines

Wanandy, Nico Stanislaus · 2007

Full title: A study of apoptosis and cell cycle to augment transfection efficiency in CHO cell lines

Authors: Wanandy, Nico Stanislaus

DOI: http://hdl.handle.net/1959.4/40868

Thesis

Construction, expression and characterisation of a human anti-CD48 monoclonal antibody

Wei, Jiewei · 2006

Full title: Construction, expression and characterisation of a human anti-CD48 monoclonal antibody

Authors: Wei, Jiewei

DOI: http://hdl.handle.net/1959.4/27413

Thesis

Investigation of the factors affecting serum-free growth of the animal cell line CHO K1

Bridges, Michael · 1995

Full title: Investigation of the factors affecting serum-free growth of the animal cell line CHO K1

Authors: Bridges, Michael

DOI: http://hdl.handle.net/1959.4/57409

Thesis

Increasing biomass production in bioreactors applying metabolic analysis and engineering tools

Comas Sanchez, Pere · 2021

Full title: Increasing biomass production in bioreactors applying metabolic analysis and engineering tools

Authors: Comas Sanchez, Pere

DOI: http://hdl.handle.net/10803/671074

Thesis

Development of tools for monitoring and controlling cell cultures through the metabolic analysis

Martínez Monge, Iván · 2018

Full title: Development of tools for monitoring and controlling cell cultures through the metabolic analysis

Authors: Martínez Monge, Iván

DOI: http://hdl.handle.net/10803/664350

Thesis

Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.

Kumpel, Belinda M; Saldova, Radka; Koeleman, Carolien AM et al. · 2021

Full title: Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.

DOI: https://www.repository.cam.ac.uk/handle/1810/316867

Thesis

Enhancing the Functionality of a Microscale Bioreactor System as an Industrial Process Development Tool for Mammalian Perfusion Culture

Sewell, David J; Turner, Richard; Field, Ray et al. · 2019

Full title: Enhancing the Functionality of a Microscale Bioreactor System as an Industrial Process Development Tool for Mammalian Perfusion Culture

Authors: Sewell, David J; Turner, Richard; Field, Ray; Holmes, William; Pradhan, Rahul; Spencer, Christopher; Oliver, Stephen; Slater, Nigel; Dikicioglu, Duygu

DOI: https://www.repository.cam.ac.uk/handle/1810/289313

Thesis

Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.

Traustason, Bergthor; Cheeks, Matthew; Dikicioglu, Duygu · 2020

Full title: Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.

Authors: Traustason, Bergthor; Cheeks, Matthew; Dikicioglu, Duygu

DOI: https://www.repository.cam.ac.uk/handle/1810/301284

Thesis

Challenges and Opportunities for the Large-Scale Chemoenzymatic Glycoengineering of Therapeutic N-Glycosylated Monoclonal Antibodies

Ivanova, Adelina; Falcioni, Francesco · 2022

Full title: Challenges and Opportunities for the Large-Scale Chemoenzymatic Glycoengineering of Therapeutic N-Glycosylated Monoclonal Antibodies

Authors: Ivanova, Adelina; Falcioni, Francesco

DOI: https://www.repository.cam.ac.uk/handle/1810/334145

Thesis

Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Murayyan, Abdulmonem · 2013

Full title: Development and Application of a Rational Design for Evaluation and Optimization of Animal Derived Component Free Media Formulation

Authors: Murayyan, Abdulmonem

DOI: http://hdl.handle.net/10214/6604

Thesis

The Assessment of MAb Quality and Quantity

Drouillard, Gerald · 2015

Full title: The Assessment of MAb Quality and Quantity

Authors: Drouillard, Gerald

DOI: http://hdl.handle.net/10214/8743

Thesis

High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

Zhang, Ye · 2017

Full title: High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

Authors: Zhang, Ye

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-207600

Thesis

Genomic and transcriptomic approaches for the advancement of CHO cell bioprocessing

Vishwanathan, Nandita · 2014

Full title: Genomic and transcriptomic approaches for the advancement of CHO cell bioprocessing

Authors: Vishwanathan, Nandita

DOI: http://hdl.handle.net/11299/165110

Thesis

Computational Fluid Dynamics Simulations of Single-Use Bioreactors for the Scale-Up of Cell Culture Processes

Kreitmayer, Diana · 2022

Full title: Computational Fluid Dynamics Simulations of Single-Use Bioreactors for the Scale-Up of Cell Culture Processes

Authors: Kreitmayer, Diana

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/32116/1/DissertationDianaKreitmayer.pdf

Thesis

Methods for cell line and protein engineering

Lundqvist, Magnus · 2018

Full title: Methods for cell line and protein engineering

Authors: Lundqvist, Magnus

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-227195

Thesis

Macroscopic models of Chinese hamster ovary cell cultures

Hagrot, Erika · 2019

Full title: Macroscopic models of Chinese hamster ovary cell cultures

Authors: Hagrot, Erika

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-262850

Thesis

Cell line and protein engineering tools for production and characterization of biologics

Volk, Anna-Luisa · 2017

Full title: Cell line and protein engineering tools for production and characterization of biologics

Authors: Volk, Anna-Luisa

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-212931

Thesis

Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis

Magnetic bead-based isolation of biological therapeutic modalities

Brechmann, Nils A. · 2022

Full title: Magnetic bead-based isolation of biological therapeutic modalities

Authors: Brechmann, Nils A.

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-321336

Thesis

A computational framework for predicting CHO cell culture performance in bioreactors

Cárcamo Behrens, Martín. · 2019

Full title: A computational framework for predicting CHO cell culture performance in bioreactors

Authors: Cárcamo Behrens, Martín.

DOI: https://hdl.handle.net/1721.1/123055

Thesis

Recycling and Regeneration of Spent Perfusion Media via Ion Concentration Polarization

Wynne, Eric Michael · 2025

Full title: Recycling and Regeneration of Spent Perfusion Media via Ion Concentration Polarization

Authors: Wynne, Eric Michael

DOI: https://hdl.handle.net/1721.1/164151

Thesis

Glycosylation site occupancy heterogeneity in Chinese hamster ovary cell culture

Nyberg, Gregg B. (Gregg Bartell), 1970- · 2005

Full title: Glycosylation site occupancy heterogeneity in Chinese hamster ovary cell culture

Authors: Nyberg, Gregg B. (Gregg Bartell), 1970-

DOI: http://hdl.handle.net/1721.1/28190

Thesis

Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays

Rohskopf, Zhumei · 2023

Full title: Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays

Authors: Rohskopf, Zhumei

DOI: https://hdl.handle.net/1721.1/152457

Thesis

Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Maloney, Andrew John · 2025

Full title: Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Authors: Maloney, Andrew John

DOI: https://hdl.handle.net/1721.1/158315

Thesis

Increasing IFN-[gamma] productivity in CHO cells through CDK inhibition

McClain, David Alan · 2010

Full title: Increasing IFN-[gamma] productivity in CHO cells through CDK inhibition

Authors: McClain, David Alan

DOI: http://hdl.handle.net/1721.1/60138

Thesis

Systems Engineering for Viral Vector Manufacturing

Nguyen, Tam Ngoc Thanh · 2023

Full title: Systems Engineering for Viral Vector Manufacturing

Authors: Nguyen, Tam Ngoc Thanh

DOI: https://hdl.handle.net/1721.1/150243

Thesis

Active hypothermic growth : a novel means for increasing total recombinant protein production by CHO cells

Fox, Stephen Richard · 2008

Full title: Active hypothermic growth : a novel means for increasing total recombinant protein production by CHO cells

Authors: Fox, Stephen Richard

DOI: http://dspace.mit.edu/handle/1721.1/32333

Thesis

Comparison of the growth and monoclonal antibody production of suspended mammalian cells in three perfusion systems

Hufford, Kathy (Kathy E.) · 2008

Full title: Comparison of the growth and monoclonal antibody production of suspended mammalian cells in three perfusion systems

Authors: Hufford, Kathy (Kathy E.)

DOI: http://hdl.handle.net/1721.1/39921

Thesis

Molecular, Genetic, and Process Approaches for Improving Secreted Pharmaceutical Protein Quality in Komagataella phaffii

Yang, Yuchen · 2024

Full title: Molecular, Genetic, and Process Approaches for Improving Secreted Pharmaceutical Protein Quality in Komagataella phaffii

Authors: Yang, Yuchen

DOI: https://hdl.handle.net/1721.1/157251

Thesis

Enhancing mammalian bioprocessing through engineering Chinese hamster ovary cell metabolism

Hefzi, Hooman · 2018

Full title: Enhancing mammalian bioprocessing through engineering Chinese hamster ovary cell metabolism

Authors: Hefzi, Hooman

DOI: https://escholarship.org/uc/item/91h2z79t

Thesis

Characterization of the down regulation of antibody production in high cell density perfusion culture

Morrill, Joyce Catherine · 2006

Full title: Characterization of the down regulation of antibody production in high cell density perfusion culture

Authors: Morrill, Joyce Catherine

DOI: http://hdl.handle.net/1721.1/32602

Thesis

Strategies to improve protein production of Chinese hamster ovary cell lines and genome annotation under the guidance of high throughput omics technology

Li, Shangzhong · 2019

Full title: Strategies to improve protein production of Chinese hamster ovary cell lines and genome annotation under the guidance of high throughput omics technology

Authors: Li, Shangzhong

DOI: https://escholarship.org/uc/item/1d30f4xc

Thesis

Molecular dynamics of monoclonal antibody production in high density perfused bioreactors

Buser, Claudia Waltraut · 2008

Full title: Molecular dynamics of monoclonal antibody production in high density perfused bioreactors

Authors: Buser, Claudia Waltraut

DOI: http://hdl.handle.net/1721.1/43915

Thesis

Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Cosenza, Zachary Anthony · 2022

Full title: Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Authors: Cosenza, Zachary Anthony

DOI: https://escholarship.org/uc/item/119489fc

Thesis

Quantitative Analysis of Proteome Dynamics in Chinese Hamster Ovary cells

Florczak, Beata D · 2019

Full title: Quantitative Analysis of Proteome Dynamics in Chinese Hamster Ovary cells

Authors: Florczak, Beata D

DOI: https://etheses.whiterose.ac.uk/id/eprint/25823/1/B.Florczak_thesis.pdf

Thesis

Applications of Protein Engineering in Synthetic Biology and Bioproduction

Minami, Shiaki · 2023

Full title: Applications of Protein Engineering in Synthetic Biology and Bioproduction

Authors: Minami, Shiaki

DOI: https://escholarship.org/uc/item/8p08541h

Thesis

Engineering Oxidative Stress Resistance in CHO Cell Factories

Fairbrass, Danielle L · 2016

Full title: Engineering Oxidative Stress Resistance in CHO Cell Factories

Authors: Fairbrass, Danielle L

DOI: https://etheses.whiterose.ac.uk/id/eprint/16227/1/Master_Copy_DLFairbrassThesis.pdf

Thesis

High-Throughput Platform Development for Chinese Hamster Ovary (CHO) Cell Culture Performance Enhancement Using Small Molecules.

Kalsi, Devika · 2018

Full title: High-Throughput Platform Development for Chinese Hamster Ovary (CHO) Cell Culture Performance Enhancement Using Small Molecules.

Authors: Kalsi, Devika

DOI: https://etheses.whiterose.ac.uk/id/eprint/23127/1/Devika%20Kalsi%20PhD%20Thesis_corrected%20copy.pdf

Thesis

Multigene engineering of secretion in mammalian cell factories

Barber, Nicholas · 2019

Full title: Multigene engineering of secretion in mammalian cell factories

Authors: Barber, Nicholas

DOI: https://etheses.whiterose.ac.uk/id/eprint/25495/1/FINALPDF%20NB%20Jun19%20corrections%20Multigene%20engineering%20of%20secretion%20in%20mammalian%20cell%20factories.pdf

Thesis

Investigating the rules governing N-linked glycosylation of Biologics

Ayre, Josephine · 2023

Full title: Investigating the rules governing N-linked glycosylation of Biologics

Authors: Ayre, Josephine

DOI: https://etheses.whiterose.ac.uk/id/eprint/34913/1/Ayre_204009713_CorrectedThesisClean2.pdf

Thesis

Manipulation of Endoplasmic Reticulum Folding and Assembly Machinery for Improved Production of Complex Biotherapeutics

Swindley, Oscar · 2021

Full title: Manipulation of Endoplasmic Reticulum Folding and Assembly Machinery for Improved Production of Complex Biotherapeutics

Authors: Swindley, Oscar

DOI: https://etheses.whiterose.ac.uk/id/eprint/29353/1/Oscar_Swindley_Thesis_Corrected_FinalAmendment_Aug2021.pdf

Thesis

Screening and development of natural compounds as tools to improve IgG production and quality in recombinant CHO cell culture

Toronjo Urquiza, Luis · 2018

Full title: Screening and development of natural compounds as tools to improve IgG production and quality in recombinant CHO cell culture

Authors: Toronjo Urquiza, Luis

Thesis

Characterisation of Cell Lines with Engineered Golgi Organisation

Spencer, Hannah · 2022

Full title: Characterisation of Cell Lines with Engineered Golgi Organisation

Authors: Spencer, Hannah

DOI: https://etheses.whiterose.ac.uk/id/eprint/31162/1/HannahSpencerThesis.pdf

Thesis

CHO cell multigene engineering by directed evolution

Jawara, Chillel · 2023

Full title: CHO cell multigene engineering by directed evolution

Authors: Jawara, Chillel

DOI: https://etheses.whiterose.ac.uk/id/eprint/36961/1/Jawara_Chillel_190186993_PhDThesis_Final.pdf

Thesis

Using Emerging Next-Generation Sequencing Technologies to Enhance the Lifecycle of Biopharmaceuticals

shamie, isaac · 2022

Full title: Using Emerging Next-Generation Sequencing Technologies to Enhance the Lifecycle of Biopharmaceuticals

Authors: shamie, isaac

DOI: https://escholarship.org/uc/item/55x7t985

Thesis

Integrated cell and bioprocess engineering for rapid and intensive continuous production of biopharmaceuticals

Morgan-Evans, William · 2020

Full title: Integrated cell and bioprocess engineering for rapid and intensive continuous production of biopharmaceuticals

Authors: Morgan-Evans, William

Thesis

Developing novel biosensors for monitoring antibody production in Chinese Hamster Ovary (CHO) cells

Willmott, Jessica · 2022

Full title: Developing novel biosensors for monitoring antibody production in Chinese Hamster Ovary (CHO) cells

Authors: Willmott, Jessica

DOI: https://etheses.whiterose.ac.uk/id/eprint/32583/1/Willmott%2C%20Jessica%2C%20170246628%20-%20Complete%20with%20Corrections.pdf

Thesis

Use of CHO cell synthetic promoters to control transcription of mAb expression vector genes and screening of ER genes for their effect on mAb production

Kerry, William · 2022

Full title: Use of CHO cell synthetic promoters to control transcription of mAb expression vector genes and screening of ER genes for their effect on mAb production

Authors: Kerry, William

DOI: https://etheses.whiterose.ac.uk/id/eprint/32010/2/William%20Kerry%20Corrected%20PhD%20thesis%20November%202022%20minus%20appendix.pdf

Thesis

Adaptation to suspension growth: analysing the surface of suspension growth adapted Chinese hamster ovary cells

Walther, Christa G · 2013

Full title: Adaptation to suspension growth: analysing the surface of suspension growth adapted Chinese hamster ovary cells

Authors: Walther, Christa G

DOI: https://etheses.whiterose.ac.uk/id/eprint/4193/1/final_version_-_all_chapters.pdf

Thesis

Development of an integrated platform for the production of recombinant biopharmaceuticals

Segarra, Camille · 2013

Full title: Development of an integrated platform for the production of recombinant biopharmaceuticals

Authors: Segarra, Camille

DOI: https://etheses.whiterose.ac.uk/id/eprint/4147/1/Segarra_Thesis_PostCorrections.pdf

Thesis

Characterising Chinese Hamster Ovary Cell Extracellular Vesicle Production in Biopharmaceutical Manufacturing

O'Donnell, Fergal · 2022

Full title: Characterising Chinese Hamster Ovary Cell Extracellular Vesicle Production in Biopharmaceutical Manufacturing

Authors: O'Donnell, Fergal

DOI: https://etheses.whiterose.ac.uk/id/eprint/33062/1/Thesis_Corrections.pdf

Thesis

The role of intracellular signalling pathways in CHO cell growth in a synthetic environment

Whitfield, Robert · 2014

Full title: The role of intracellular signalling pathways in CHO cell growth in a synthetic environment

Authors: Whitfield, Robert

DOI: https://etheses.whiterose.ac.uk/id/eprint/6454/1/Rob%20Whitfield%20Final%20Thesis%20Submission.pdf

Thesis

Cell Line and Process Development for Improved Transient Production of a "Difficult-to-Express" Fusion Protein by CHO Cells

Johari, YB · 2015

Full title: Cell Line and Process Development for Improved Transient Production of a "Difficult-to-Express" Fusion Protein by CHO Cells

Authors: Johari, YB

DOI: https://etheses.whiterose.ac.uk/id/eprint/9265/1/PhD%20thesis%20-%20YB%20Johari%20%5BFINAL%5D.pdf

Thesis

Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

Zagari, Francesca · 2012

Full title: Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

Authors: Zagari, Francesca

DOI: https://infoscience.epfl.ch/handle/20.500.14299/84627

Thesis

OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up

Tissot, Stéphanie · 2011

Full title: OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up

Authors: Tissot, Stéphanie

DOI: https://infoscience.epfl.ch/handle/20.500.14299/68752

Thesis

Study of transposon-mediated cell pool and cell line generation in CHO cells

Balasubramanian, Sowmya · 2015

Full title: Study of transposon-mediated cell pool and cell line generation in CHO cells

Authors: Balasubramanian, Sowmya

DOI: https://infoscience.epfl.ch/handle/20.500.14299/113896

Thesis

Influence of cell-line and process conditions on the glycosylation of recombinant proteins

Nahrgang, Stefan · 2005

Full title: Influence of cell-line and process conditions on the glycosylation of recombinant proteins

Authors: Nahrgang, Stefan

DOI: https://infoscience.epfl.ch/handle/20.500.14299/211632

Thesis

Transient gene expression for rapid protein production : studies & optimizations under serum-free conditions

Muller, Natalie · 2005

Full title: Transient gene expression for rapid protein production : studies & optimizations under serum-free conditions

Authors: Muller, Natalie

DOI: https://infoscience.epfl.ch/handle/20.500.14299/214287

Thesis

ELUCIDATING MAMMALIAN CELL METABOLISM USING ‘OMICS TO ENHANCE BIOPROCESS CAPABILITIES

Dhara, Venkata Gayatri · 2022

Full title: ELUCIDATING MAMMALIAN CELL METABOLISM USING ‘OMICS TO ENHANCE BIOPROCESS CAPABILITIES

Authors: Dhara, Venkata Gayatri

DOI: http://jhir.library.jhu.edu/handle/1774.2/66775

Thesis

CELL ENGINEERING AND CULTURE MEDIA MODIFICATION STUDIES TO IMPROVE THE CELL CULTURE PERFORMANCE

Dhara, Venkata Gayatri · 2019

Full title: CELL ENGINEERING AND CULTURE MEDIA MODIFICATION STUDIES TO IMPROVE THE CELL CULTURE PERFORMANCE

Authors: Dhara, Venkata Gayatri

DOI: http://jhir.library.jhu.edu/handle/1774.2/60428

Thesis

Glycoengineering of Chinese Hamster Ovary cells for improving biotherapeutics’ efficacies.

Chung, Cheng-yu · 2019

Full title: Glycoengineering of Chinese Hamster Ovary cells for improving biotherapeutics’ efficacies.

Authors: Chung, Cheng-yu

DOI: http://jhir.library.jhu.edu/handle/1774.2/60731

Thesis

Predictive models for upstream mammalian cell culture development: a review

Yatipanthalawa, BS; Gras, SL · 2023

Full title: Predictive models for upstream mammalian cell culture development: a review

Authors: Yatipanthalawa, BS; Gras, SL

DOI: https://hdl.handle.net/11343/339523

Thesis

Rapid Media Transition for Metabolic Control Analysis of Fed-Batch Fermentation Processes

Link, Hannes Peter · 2009

Full title: Rapid Media Transition for Metabolic Control Analysis of Fed-Batch Fermentation Processes

Authors: Link, Hannes Peter

DOI: https://mediatum.ub.tum.de/796895

Thesis

Probing Control : Analysis and Design with Application to Fed-Batch Bioreactors

Velut, Stéphane · 2005

Full title: Probing Control : Analysis and Design with Application to Fed-Batch Bioreactors

Authors: Velut, Stéphane

DOI: https://lup.lub.lu.se/record/24605

Thesis

Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Hong, Moo Sun · 2022

Full title: Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Authors: Hong, Moo Sun

DOI: https://hdl.handle.net/1721.1/138943

Thesis

Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing

Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP] et al. · 2019

Full title: Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing

Authors: Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP]; Deffune, Elenice; Suazo, Cláudio Alberto Torres

DOI: http://dx.doi.org/10.1590/0104-6632.20180352s20160463

Thesis

Model comparison to describe BHK-21 cell growth and metabolism in stirred tank bioreactors operated in batch mode

Fernández Núñez, Eutimio Gustavo · 2018

Full title: Model comparison to describe BHK-21 cell growth and metabolism in stirred tank bioreactors operated in batch mode

Authors: Fernández Núñez, Eutimio Gustavo

DOI: https://doi.org/10.1590/0104-6632.20180352s20160592

Thesis

NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods

De Leoz, Maria Lorna A; Duewer, David L; Fung, Adam et al. · 2020

Full title: NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods

DOI: https://dspace.library.uu.nl/handle/1874/394141

Thesis

Automated pipeline for rapid production and screening of HIV-specific monoclonal antibodies using pichia pastoris

Shah, Kartik A; Clark, John J; Goods, Brittany A. et al. · 2017

Full title: Automated pipeline for rapid production and screening of HIV-specific monoclonal antibodies using pichia pastoris

Authors: Shah, Kartik A; Clark, John J; Goods, Brittany A.; Politano, Timothy James; Mozdzierz, Nicholas Joseph; Zimnisky, Ross; Leeson, Rachel; Love, John C; Love, Kerry R.

DOI: http://hdl.handle.net/1721.1/109438

Thesis

Effect of adenosine and cordycepin on recombinant antibody production yields in two different Chinease hamster ovary cell lines

Jarusintanakorn, Salinthip; Rangnoi, Kuntalee; Yamabhai, Montarop et al. · 2024

Full title: Effect of adenosine and cordycepin on recombinant antibody production yields in two different Chinease hamster ovary cell lines

Authors: Jarusintanakorn, Salinthip; Rangnoi, Kuntalee; Yamabhai, Montarop; Mastrobattista, Enrico

DOI: https://dspace.library.uu.nl/handle/1874/438035

Thesis

Microfluidic Cell Retention Device for Perfusion of Mammalian Suspension Culture

Prentice, Holly; Warkiani, Majid Ebrahimi; Kwon, Taehong et al. · 2017

Full title: Microfluidic Cell Retention Device for Perfusion of Mammalian Suspension Culture

Authors: Prentice, Holly; Warkiani, Majid Ebrahimi; Kwon, Taehong; De Oliveira, Jonas; Madziva, Nyasha; Hamel, Jean-Francois P; Han, Jongyoon

DOI: http://hdl.handle.net/1721.1/112686

Thesis

Small-molecule control of antibody N-glycosylation in engineered mammalian cells

Chang, Michelle; Gaidukov, Leonid; Jung, Giyoung et al. · 2020

Full title: Small-molecule control of antibody N-glycosylation in engineered mammalian cells

DOI: https://hdl.handle.net/1721.1/125977

Thesis

Investigating the influence of physiologically relevant hydrostatic pressure on CHO cell batch culture

Shang, Menglin; Kwon, Taehong; Hamel, Jean-Francois P et al. · 2022

Full title: Investigating the influence of physiologically relevant hydrostatic pressure on CHO cell batch culture

Authors: Shang, Menglin; Kwon, Taehong; Hamel, Jean-Francois P; Lim, Chwee Teck; Khoo, Bee Luan; Han, Jongyoon

DOI: https://hdl.handle.net/1721.1/143608

Thesis

Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe et al. · 2016

Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

Authors: López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe; Carrillo-Cocom, Leydi Maribel; Rocha-Pizaña, María del Refugio; Alvarez, Mario Moises

DOI: http://hdl.handle.net/1721.1/105504

Thesis

Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

Sumit, Madhuresh; Dolatshahi, Sepideh; Chu, An-Hsiang Adam et al. · 2020

Full title: Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

DOI: https://hdl.handle.net/1721.1/125974

Thesis

A multi-landing pad DNA integration platform for mammalian cell engineering

Wroblewska, Liliana; Nelson, Tom; Zhang, Xin et al. · 2018

Full title: A multi-landing pad DNA integration platform for mammalian cell engineering

DOI: http://hdl.handle.net/1721.1/115278

Thesis

Preemptive variation reduction in biologic drug substance manufacturing

Güereca Valdivia, Ismael · 2024

Full title: Preemptive variation reduction in biologic drug substance manufacturing

Authors: Güereca Valdivia, Ismael

DOI: https://hdl.handle.net/1721.1/155982

Thesis

Industry 4.0 in Biomanufacturing: Predictive Real-Time Models Using Process Analytical Technology

Murr, Michaela · 2023

Full title: Industry 4.0 in Biomanufacturing: Predictive Real-Time Models Using Process Analytical Technology

Authors: Murr, Michaela

DOI: https://hdl.handle.net/1721.1/151710

Thesis

Continuous Online Protein Quality Monitoring during Perfusion Culture Production Using an Integrated Micro/Nanofluidic System

Kwon, Taehong; Ko, Sung Hee; Hamel, Jean-Francois P et al. · 2020

Full title: Continuous Online Protein Quality Monitoring during Perfusion Culture Production Using an Integrated Micro/Nanofluidic System

Authors: Kwon, Taehong; Ko, Sung Hee; Hamel, Jean-Francois P; Han, Jongyoon

DOI: https://hdl.handle.net/1721.1/125538

Thesis

An Investigation of Multivariate Process Control for Biomanufacturing

Lui, Christopher A. · 2022

Full title: An Investigation of Multivariate Process Control for Biomanufacturing

Authors: Lui, Christopher A.

DOI: https://hdl.handle.net/1721.1/139505

Thesis

Challenging the workhorse: Comparative analysis of eukaryotic micro‐organisms for expressing monoclonal antibodies

Jiang, Hanxiao; Horwitz, Andrew A; Wright, Chapman et al. · 2021

Full title: Challenging the workhorse: Comparative analysis of eukaryotic micro‐organisms for expressing monoclonal antibodies

DOI: https://hdl.handle.net/1721.1/134784

Thesis

Enhancing Production of Recombinant Proteins from Mammalian Cells

Wong, Victor V.T.; Wong, Niki S.C.; Tan, Hong-Kiat et al. · 2003

Full title: Enhancing Production of Recombinant Proteins from Mammalian Cells

Authors: Wong, Victor V.T.; Wong, Niki S.C.; Tan, Hong-Kiat; Wang, Daniel I.C.; Yap, Miranda G.S.

DOI: http://hdl.handle.net/1721.1/3782

Thesis

Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in Komagataella phaffii

Yang, Yuchen; Dalvie, Neil C; Brady, Joseph R et al. · 2025

Full title: Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in Komagataella phaffii

DOI: https://hdl.handle.net/1721.1/163225

Thesis

Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool

Puarattana-aroonkorn, Sitthiphol; Tharakaraman, Kannan; Suriyawipada, Disapan et al. · 2024

Full title: Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool

Authors: Puarattana-aroonkorn, Sitthiphol; Tharakaraman, Kannan; Suriyawipada, Disapan; Ruchirawat, Mathuros; Fuangthong, Mayuree; Sasisekharan, Ram; Artpradit, Charlermchai

DOI: https://hdl.handle.net/1721.1/155543

Thesis

Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel et al. · 2025

Full title: Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Authors: Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel; Dang, Brendan; Wolffe, Lenna A; Atari, Adel; Tseng, Yuen-Yi; Love, J Christopher

DOI: https://hdl.handle.net/1721.1/163220

Thesis

Active Hypothermic Growth: A Novel Means For Increasing Total Interferon-γ Production by Chinese Hamster Ovary Cells

Stephen R., Fox; Yap, Mei Xia; Yap, Miranda G.S. et al. · 2005

Full title: Active Hypothermic Growth: A Novel Means For Increasing Total Interferon-γ Production by Chinese Hamster Ovary Cells

Authors: Stephen R., Fox; Yap, Mei Xia; Yap, Miranda G.S.; Wang, Daniel I.C.

DOI: http://hdl.handle.net/1721.1/30379

Thesis

The Effect of Culture Temperature on Recombinant IFN-γ Production and Quality

Fox, Steven R.; Yap, Miranda G.S.; Wang, Daniel I.C. · 2003

Full title: The Effect of Culture Temperature on Recombinant IFN-γ Production and Quality

Authors: Fox, Steven R.; Yap, Miranda G.S.; Wang, Daniel I.C.

DOI: http://hdl.handle.net/1721.1/3928

Thesis

CIRP Expression on Growth and Productivity of CHO Cells

Tan, Hong-Kiat; Yap, Miranda G.S.; Wang, Daniel I.C. · 2005

Full title: CIRP Expression on Growth and Productivity of CHO Cells

Authors: Tan, Hong-Kiat; Yap, Miranda G.S.; Wang, Daniel I.C.

DOI: http://hdl.handle.net/1721.1/30382

Thesis

Reduced Temperature Production of Recombinant Proteins to Increase Productivity in Mammalian Cell Culture

Fox, Steven R.; Wang, Daniel I.C.; Yap, Miranda G.S. · 2003

Full title: Reduced Temperature Production of Recombinant Proteins to Increase Productivity in Mammalian Cell Culture

Authors: Fox, Steven R.; Wang, Daniel I.C.; Yap, Miranda G.S.

DOI: http://hdl.handle.net/1721.1/3946

Thesis

Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins

Bosques, Carlos J.; Collins, Brian E.; Meador, James W. et al. · 2014

Full title: Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins

DOI: http://hdl.handle.net/1721.1/89032

Thesis

Variability in the Stability and Productivity of Transfected Genes in Chinese Hamster Ovary (CHO) cells

Ng, Say Kong; Yap, Miranda G.S.; Wang, Daniel I.C. · 2004

Full title: Variability in the Stability and Productivity of Transfected Genes in Chinese Hamster Ovary (CHO) cells

Authors: Ng, Say Kong; Yap, Miranda G.S.; Wang, Daniel I.C.

DOI: http://hdl.handle.net/1721.1/7504

Thesis

Naming CHO cells for bio-manufacturing: Genome plasticity and variant phenotypes of cell populations in bioreactors question the relevance of old names

Wurm, Maria J.; Wurm, Florian M. · 2021

Full title: Naming CHO cells for bio-manufacturing: Genome plasticity and variant phenotypes of cell populations in bioreactors question the relevance of old names

Authors: Wurm, Maria J.; Wurm, Florian M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/179941

Thesis

Trimeric SARS-CoV-2 Spike Proteins Produced from CHO Cells in Bioreactors Are High-Quality Antigens

Pino, Paco; Kint, Joeri; Kiseljak, Divor et al. · 2021

Full title: Trimeric SARS-CoV-2 Spike Proteins Produced from CHO Cells in Bioreactors Are High-Quality Antigens

DOI: https://infoscience.epfl.ch/handle/20.500.14299/174671

Thesis

Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection-A Simulation Study

Hernandez Rodriguez, Tanja; Morerod, Sophie; Poertner, Ralf et al. · 2021

Full title: Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection-A Simulation Study

Authors: Hernandez Rodriguez, Tanja; Morerod, Sophie; Poertner, Ralf; Wurm, Florian M.; Frahm, Bjorn

DOI: https://infoscience.epfl.ch/handle/20.500.14299/180009

Thesis

A Robust, High-Titer, Semi-Automated, and In-Culture Antibody-Capturing Transient CHO Platform Technology

Gebhardt, L. P.; Abel, Molica; Zhou, Jing et al. · 2025

Full title: A Robust, High-Titer, Semi-Automated, and In-Culture Antibody-Capturing Transient CHO Platform Technology

DOI: https://infoscience.epfl.ch/handle/20.500.14299/255058

Thesis

Cloning of CHO Cells, Productivity and Genetic Stability—A Discussion

Wurm, Florian · 2020

Full title: Cloning of CHO Cells, Productivity and Genetic Stability—A Discussion

Authors: Wurm, Florian

DOI: https://infoscience.epfl.ch/handle/20.500.14299/169672

Thesis

Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

Muller, N.; Derouazi, M.; Van Tilborgh, F. et al. · 2007

Full title: Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

Authors: Muller, N.; Derouazi, M.; Van Tilborgh, F.; Wulhfard, S.; Hacker, D. L.; Jordan, M.; Wurm, F. M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/9754

Thesis

A new approach for identifying positional isomers of glycans cleaved from monoclonal antibodies

Dyukova, Irina; Ben Faleh, Ahmed; Warnke, Stephan et al. · 2021

Full title: A new approach for identifying positional isomers of glycans cleaved from monoclonal antibodies

Authors: Dyukova, Irina; Ben Faleh, Ahmed; Warnke, Stephan; Yalovenko, Natalia; Yatsyna, Vasyl; Bansal, Priyanka; Rizzo, Thomas R.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/179989

Thesis

Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

Zhang, Xiaowei; Garcia, Isabel Fernandez; Baldi, Lucia et al. · 2010

Full title: Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

Authors: Zhang, Xiaowei; Garcia, Isabel Fernandez; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/52051

Thesis

Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells

Davami, Fatemeh; Baldi, Lucia; Rajendra, Yashas et al. · 2014

Full title: Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells

Authors: Davami, Fatemeh; Baldi, Lucia; Rajendra, Yashas; M Wurm, Florian

DOI: https://infoscience.epfl.ch/handle/20.500.14299/108905

Thesis

Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells

Meuwly, F.; von Stockar, U.; Kadouri, A. · 2006

Full title: Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells

Authors: Meuwly, F.; von Stockar, U.; Kadouri, A.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226104

Thesis

OVEREXPRESSION OF SLC15A1 GENE IN CHO-S CELLS TO INCREASE DIPEPTIDE UPTAKE RATE

Liu, Shuman · 2021

Full title: OVEREXPRESSION OF SLC15A1 GENE IN CHO-S CELLS TO INCREASE DIPEPTIDE UPTAKE RATE

Authors: Liu, Shuman

DOI: http://jhir.library.jhu.edu/handle/1774.2/64522

Thesis

HIGH EFFICIENCY AFFINITY CAPTURE AND PURIFICATION OF IMMUNOGLOBULIN G USING MAGNETIC PARTICLES WITH BIOINSPIRIED PEPTIDE LIGANDS

Ou, Shih-Hao · 2019

Full title: HIGH EFFICIENCY AFFINITY CAPTURE AND PURIFICATION OF IMMUNOGLOBULIN G USING MAGNETIC PARTICLES WITH BIOINSPIRIED PEPTIDE LIGANDS

Authors: Ou, Shih-Hao

DOI: http://jhir.library.jhu.edu/handle/1774.2/61606

Thesis

Optimization of Recombinant Protein Production in Different Cell Lines

Ouyang, Chu · 2024

Full title: Optimization of Recombinant Protein Production in Different Cell Lines

Authors: Ouyang, Chu

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/69633

Thesis

Improvement of Erythropoietin N-glycan Branching and Sialylation by Overexpression of Glycosyltransferases

Gao, Yuan · 2016

Full title: Improvement of Erythropoietin N-glycan Branching and Sialylation by Overexpression of Glycosyltransferases

Authors: Gao, Yuan

DOI: http://jhir.library.jhu.edu/handle/1774.2/39421

Thesis

Screening for Antibody Reduction at the Clone Selection Stage to Prevent Reduction During Manufacturing

Lakhani, Aliya Abdulaziz · 2019

Full title: Screening for Antibody Reduction at the Clone Selection Stage to Prevent Reduction During Manufacturing

Authors: Lakhani, Aliya Abdulaziz

DOI: http://jhir.library.jhu.edu/handle/1774.2/60150

Thesis

Protocol for production and expression of chimeric bovine-human monoclonal antibodies

Heydarchi, B; Purcell, DFJ · 2023

Full title: Protocol for production and expression of chimeric bovine-human monoclonal antibodies

Authors: Heydarchi, B; Purcell, DFJ

DOI: https://hdl.handle.net/11343/334751

Thesis

Production and characterization of specific monoclonal antibodies binding the Plasmodium falciparum diagnostic biomarker, histidine-rich protein 2

Leow, CH; Jones, M; Cheng, Q et al. · 2021

Full title: Production and characterization of specific monoclonal antibodies binding the Plasmodium falciparum diagnostic biomarker, histidine-rich protein 2

Authors: Leow, CH; Jones, M; Cheng, Q; Mahler, S; McCarthy, J

DOI: https://hdl.handle.net/11343/277268

Thesis

Impact on product quality of high productive GS-CHO cell lines.

Perani, A; Gloria, B; Wang, D et al. · 2022

Full title: Impact on product quality of high productive GS-CHO cell lines.

Authors: Perani, A; Gloria, B; Wang, D; Murphy, R; Singh, HK; Smyth, FE; Scott, AM

DOI: https://hdl.handle.net/11343/303930

Thesis

A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments

Karimi Alavijeh, M; Lee, YY; Gras, SL · 2024

Full title: A perspective-driven and technical evaluation of machine learning in bioreactor scale-up: A case-study for potential model developments

Authors: Karimi Alavijeh, M; Lee, YY; Gras, SL

DOI: https://hdl.handle.net/11343/351093

Thesis

Variations in critical quality attributes (CQAs) on therapeutic monoclonal antibodies (mAbs) due to cultivation conditions, storage conditions and external stress-factors

Nash, Felicia; Sannum, Emma · 2024

Full title: Variations in critical quality attributes (CQAs) on therapeutic monoclonal antibodies (mAbs) due to cultivation conditions, storage conditions and external stress-factors

Authors: Nash, Felicia; Sannum, Emma

DOI: http://lup.lub.lu.se/student-papers/record/9170581

Thesis

Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand

Chua, Gek Kee · 2011

Authors: Chua, Gek Kee

DOI: http://hdl.handle.net/10179/2832

Thesis

FIA-Based Process Monitoring in Simulated Bioreactor for Monoclonal Antibody Production

Fernandez Alcantara, Leonardo Renzo · 2025

Full title: FIA-Based Process Monitoring in Simulated Bioreactor for Monoclonal Antibody Production

Authors: Fernandez Alcantara, Leonardo Renzo

DOI: http://lup.lub.lu.se/student-papers/record/9188201

Thesis

Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening

Kim, Su Hyun; Shin, Seunghyeon; Baek, Minhye et al. · 2023

Full title: Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening

DOI: https://orbit.dtu.dk/en/publications/6d4a73c5-e3ad-45bb-bdcf-fcad2d316ad4

Thesis

Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium

Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Òdena, Andreu et al. · 2023

Full title: Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium

DOI: https://orbit.dtu.dk/en/publications/9841cea8-7f15-4ec0-9c98-bc7dea65684a

Thesis

Optimization of serum free medium for the production of humanized anti-cea monoclonal antibody.

Ab Latif, Nurzila · 2011

Full title: Optimization of serum free medium for the production of humanized anti-cea monoclonal antibody.

Authors: Ab Latif, Nurzila

DOI: http://psasir.upm.edu.my/id/eprint/26510/2/IB%202011%2030R.pdf

Thesis

A versatile genomic transgenesis platform with enhanced λ integrase for human Expi293F cells

Full title: A versatile genomic transgenesis platform with enhanced λ integrase for human Expi293F cells

DOI: https://phaidra.vetmeduni.ac.at/o:2395

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· 2016

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