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Evaluation Of Link Cell Therapies Logic Gated Car

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166 papers 331 patents 93 theses

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Paper SCAN-ACT: adoptive T cell therapy target discovery through single-cell transcriptomics

Stefano Testa; Aastha Pal; A. Subramanian et al. · 2025 · bioRxiv · DOI

Full title: SCAN-ACT: adoptive T cell therapy target discovery through single-cell transcriptomics

Authors: Stefano Testa; Aastha Pal; A. Subramanian; Sushama Varma; Jackie Tang; Danielle Graham; Sara Arfan; Minggui Pan; Nam Q. Bui; Kristen N. Ganjoo; Sarah Dry; Paul Huang; Matt van de Rijn; Wei Jiang; A. Kalbasi; E. Moding

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1186/s13073-025-01514-9

Paper Current challenges and therapeutic advances of CAR-T cell therapy for solid tumors

Tong Chen; Mingzhao Wang; Yanchao Chen et al. · 2024 · Cancer Cell International · DOI

Full title: Current challenges and therapeutic advances of CAR-T cell therapy for solid tumors

Authors: Tong Chen; Mingzhao Wang; Yanchao Chen; Yutao Liu

Year: 2024

Venue: Cancer Cell International

DOI: https://doi.org/10.1186/s12935-024-03315-3

Paper The Notch signaling pathway: a potential target for cancer immunotherapy

Li, Xinxin; Yan, Xianchun; Wang, Yufeng et al. · 2023 · Journal of Hematology & Oncology · DOI

Full title: The Notch signaling pathway: a potential target for cancer immunotherapy

Authors: Li, Xinxin; Yan, Xianchun; Wang, Yufeng; Kaur, Balveen; Han, Hua; Yu, Jianhua

Year: 2023

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-023-01439-z

Paper SCAN-ACT: adoptive T cell therapy target discovery through single-cell transcriptomics

Stefano Testa; Aastha Pal; A. Subramanian et al. · 2025 · bioRxiv · DOI

Full title: SCAN-ACT: adoptive T cell therapy target discovery through single-cell transcriptomics

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1186/s13073-025-01514-9

Paper Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system

Kipniss, Nathan H.; Dingal, P.C. Dave P.; Abbott, Timothy R. et al. · 2017 · Nature Communications · DOI

Full title: Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system

Authors: Kipniss, Nathan H.; Dingal, P.C. Dave P.; Abbott, Timothy R.; Gao, Yuchen; Wang, Haifeng; Dominguez, Antonia A.; Labanieh, Louai; Qi, Lei S.

Year: 2017

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-017-02075-1

Paper CAR T cell design: approaching the elusive AND-gate

Zeguo Zhao; M. Sadelain · 2023 · Cell Research · DOI

Full title: CAR T cell design: approaching the elusive AND-gate

Authors: Zeguo Zhao; M. Sadelain

Year: 2023

Venue: Cell Research

DOI: https://doi.org/10.1038/s41422-023-00828-w

Paper Driving cars to the clinic for solid tumors

Castellarin, Mauro; Watanabe, Keisuke; June, Carl H. et al. · 2018 · Gene Therapy · DOI

Full title: Driving cars to the clinic for solid tumors

Authors: Castellarin, Mauro; Watanabe, Keisuke; June, Carl H.; Kloss, Christopher C.; Posey, Avery D.

Year: 2018

Venue: Gene Therapy

DOI: https://doi.org/10.1038/s41434-018-0007-x

Paper Development of NK cell-based cancer immunotherapies through receptor engineering

Page, Audrey; Chuvin, Nicolas; Valladeau‐Guilemond, Jenny et al. · 2024 · Cellular and Molecular Immunology · DOI

Full title: Development of NK cell-based cancer immunotherapies through receptor engineering

Authors: Page, Audrey; Chuvin, Nicolas; Valladeau‐Guilemond, Jenny; Depil, Stéphane

Year: 2024

Venue: Cellular and Molecular Immunology

DOI: https://doi.org/10.1038/s41423-024-01145-x

Paper On-target restoration of a split T cell-engaging antibody for precision immunotherapy

Banaszek, Agnes; Bumm, Thomas G.P.; Nowotny, Boris et al. · 2019 · Nature Communications · DOI

Full title: On-target restoration of a split T cell-engaging antibody for precision immunotherapy

Authors: Banaszek, Agnes; Bumm, Thomas G.P.; Nowotny, Boris; Geis, Maria; Kim, Jacob; Wölfl, Matthias; Trebing, Johannes; Kucka, Kirstin; Kouhestani, Dina; Gogishvili, Tea; Krenz, Bastian; Lutz, Justina; Rasche, Leo; Hönemann, Dirk; Neuweiler, Hannes; Heiby, Julia C.; Bargou, Ralf C.; Wajant, Harald; Einsele, Hermann; Riethmüller, Gert; Stuhler, Gernot

Year: 2019

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-019-13196-0

Paper The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity

Helsen, Christopher W.; Hammill, Joanne A.; Lau, Vivian Wing Chong et al. · 2018 · Nature Communications · DOI

Full title: The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity

Authors: Helsen, Christopher W.; Hammill, Joanne A.; Lau, Vivian Wing Chong; Mwawasi, Kenneth A.; Afsahi, Arya; Bezverbnaya, Ksenia; Newhook, Lisa; Hayes, Danielle L; Aarts, Craig; Bojović, Bojana; Denisova, Galina; Kwiecień, Jacek M.; Brain, Ian; Derocher, Heather; Milne, Katy; Nelson, Brad H.; Bramson, Jonathan L.

Year: 2018

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-018-05395-y

Paper Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma

Hsiang-Chi, Tseng; Xiong, Wei; Badeti, Saiaditya et al. · 2020 · Nature Communications · DOI

Full title: Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma

Authors: Hsiang-Chi, Tseng; Xiong, Wei; Badeti, Saiaditya; Yang, Yan; Ma, Minh; Liu, Ting; Ramos, Carlos A.; Dotti, Gianpietro; Fritzky, Luke; Jiang, Jie-gen; Yi, Qing; Guarrera, James V.; Zong, Wei‐Xing; Liu, Chen; Liu, Dongfang

Year: 2020

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-020-18444-2

Paper Engineering advanced logic and distributed computing in human CAR immune cells

J. Cho; Atsushi Okuma; Katri Sofjan et al. · 2021 · Nature Communications · DOI

Full title: Engineering advanced logic and distributed computing in human CAR immune cells

Authors: J. Cho; Atsushi Okuma; Katri Sofjan; Seunghee Lee; J. Collins; W. Wong

Year: 2021

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-021-21078-7

Paper Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens

Hwang, Michael S.; Miller, Michelle S.; Thirawatananond, Puchong et al. · 2021 · Nature Communications · DOI

Full title: Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens

Authors: Hwang, Michael S.; Miller, Michelle S.; Thirawatananond, Puchong; Douglass, Jacqueline; Wright, Katharine M.; Hsiue, Emily Han-Chung; Mog, Brian J.; Aytenfisu, Tihitina Y.; Murphy, Michael; Azurmendi, P. Aitana; Skora, Andrew D.; Pearlman, Alexander H.; Paul, Suman; DiNapoli, Sarah R.; Konig, Maximilian F.; Bettegowda, Chetan; Pardoll, Drew M.; Papadopoulos, Nickolas; Kinzler, Kenneth W.; Vogelstein, Bert; Zhou, Shibin; Gabelli, Sandra B.

Year: 2021

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-021-25605-4

Paper Microenvironment-confined kinetic elucidation and implementation of a DNA nano-phage with a shielded internal computing layer

Tang, Decui; He, Shuoyao; Yang, Yani et al. · 2025 · Nature Communications · DOI

Full title: Microenvironment-confined kinetic elucidation and implementation of a DNA nano-phage with a shielded internal computing layer

Authors: Tang, Decui; He, Shuoyao; Yang, Yani; Zeng, Yuqi; Xiong, Mengyi; Ding, Ding; Wei, Weijun; Lyu, Yifan; Zhang, Xiaobing; Tan, Weihong

Year: 2025

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-025-56219-9

Paper Universal redirection of CAR T cells against solid tumours via membrane-inserted ligands for the CAR

Zhang, Angela Q.; Hostetler, Alexander; Chen, Laura E. et al. · 2023 · Nature Biomedical Engineering · DOI

Full title: Universal redirection of CAR T cells against solid tumours via membrane-inserted ligands for the CAR

Authors: Zhang, Angela Q.; Hostetler, Alexander; Chen, Laura E.; Mukkamala, Vainavi; Abraham, Wuhbet; Padilla, Lucia T.; Wolff, A; Maiorino, Laura; Backlund, Coralie M.; Aung, Aereas; Melo, Mariane B.; Li, Na; Wu, Shengwei; Irvine, Darrell J.

Year: 2023

Venue: Nature Biomedical Engineering

DOI: https://doi.org/10.1038/s41551-023-01048-8

Paper Rational design of heterodimeric receptors capable of activating target signaling molecules

Kongkrongtong, Tatphon; Zhang, Ruolan; Kawahara, Masahiro · 2021 · Scientific Reports · DOI

Full title: Rational design of heterodimeric receptors capable of activating target signaling molecules

Authors: Kongkrongtong, Tatphon; Zhang, Ruolan; Kawahara, Masahiro

Year: 2021

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-021-96396-3

Paper An oxygen sensitive self-decision making engineered CAR T-cell

Juillerat, Alexandre; Maréchal, Alan; Filhol, Jean Marie et al. · 2017 · Scientific Reports · DOI

Full title: An oxygen sensitive self-decision making engineered CAR T-cell

Authors: Juillerat, Alexandre; Maréchal, Alan; Filhol, Jean Marie; Valogne, Yannick; Valton, Julien; Duclert, Aymeric; Duchâteau, Philippe; Poirot, Laurent

Year: 2017

Venue: Scientific Reports

DOI: https://doi.org/10.1038/srep39833

Paper The Landscape of Receptor-Mediated Precision Cancer Combination Therapy: A Single-Cell Perspective

Ahmadi, Saba; Sukprasert, Pattara; Vegesna, Rahulsimham et al. · 2020 · DOI

Full title: The Landscape of Receptor-Mediated Precision Cancer Combination Therapy: A Single-Cell Perspective

Authors: Ahmadi, Saba; Sukprasert, Pattara; Vegesna, Rahulsimham; Sinha, Sanju; Schischlik, Fiorella; Artzi, Natalie; Khuller, Samir; Schäffer, Alejandro A.; Ruppin, Eytan

Year: 2020

DOI: https://doi.org/10.1101/2020.01.28.923532

Paper Remote control of CAR T cell therapies by thermal targeting

Miller, Ian C.; Sun, Lee-Kai; Harris, Adrian M. et al. · 2020 · DOI

Full title: Remote control of CAR T cell therapies by thermal targeting

Authors: Miller, Ian C.; Sun, Lee-Kai; Harris, Adrian M.; Gamboa, Lena; Zamat, Ali; Kwong, Gabriel A.

Year: 2020

DOI: https://doi.org/10.1101/2020.04.26.062703

Paper A functional screening platform for engineering chimeric antigen receptors with reduced on-target, off-tumour activation

Roberto, Raphaël B. Di; Rueda, Rocío Castellanos; Frey, Samara et al. · 2020 · DOI

Full title: A functional screening platform for engineering chimeric antigen receptors with reduced on-target, off-tumour activation

Authors: Roberto, Raphaël B. Di; Rueda, Rocío Castellanos; Frey, Samara; Egli, David; Vazquez-Lombardi, Rodrigo; Reddy, Sai T.

Year: 2020

DOI: https://doi.org/10.1101/2020.04.30.070409

Paper Design and modular assembly of synthetic intramembrane proteolysis receptors for custom gene regulation in therapeutic cells

Zhu, Iowis; Liu, Raymond; Hyrenius‐Wittsten, Axel et al. · 2021 · DOI

Full title: Design and modular assembly of synthetic intramembrane proteolysis receptors for custom gene regulation in therapeutic cells

Authors: Zhu, Iowis; Liu, Raymond; Hyrenius‐Wittsten, Axel; Piraner, Dan I.; Alavi, Josef; Israni, Divya V.; Khalil, Ahmad S.; Roybal, Kole T.

Year: 2021

DOI: https://doi.org/10.1101/2021.05.21.445218

Paper Clinically-driven design of synthetic gene regulatory programs in human cells

Israni, Divya V.; Li, Hui-Shan; Gagnon, Keith A. et al. · 2021 · DOI

Full title: Clinically-driven design of synthetic gene regulatory programs in human cells

Authors: Israni, Divya V.; Li, Hui-Shan; Gagnon, Keith A.; Sander, Jeffry D.; Roybal, Kole T.; Joung, J. Keith; Wong, Wilson W.; Khalil, Ahmad S.

Year: 2021

DOI: https://doi.org/10.1101/2021.02.22.432371

Paper Discovery and validation of novel human genomic safe harbor sites for gene and cell therapies

Aznauryan, Erik; Yermanos, Alexander; Kinzina, Elvira et al. · 2021 · DOI

Full title: Discovery and validation of novel human genomic safe harbor sites for gene and cell therapies

Authors: Aznauryan, Erik; Yermanos, Alexander; Kinzina, Elvira; Kapetanovic, Edo; Milanova, Denitsa; Church, George M.; Reddy, Sai T.

Year: 2021

DOI: https://doi.org/10.1101/2021.03.04.433856

Paper T cell circuits that sense antigen density with an ultrasensitive threshold

Hernández‐López, Rogelio A.; Yu, Wei; Cabral, Katelyn A. et al. · 2021 · Science · DOI

Full title: T cell circuits that sense antigen density with an ultrasensitive threshold

Authors: Hernández‐López, Rogelio A.; Yu, Wei; Cabral, Katelyn A.; Creasey, Olivia A.; Pazmino, Maria del Pilar Lopez; Tonai, Yurie; Guzman, Arsenia De; Mäkelä, Anna R.; Saksela, Kalle; Gartner, Zev J.; Lim, Wendell A.

Year: 2021

Venue: Science

DOI: https://doi.org/10.1126/science.abc1855

Paper Engineering chimeric antigen receptor-T cells for cancer treatment

Ye, Baixin; Stary, Creed M.; Li, Xuejun et al. · 2018 · Molecular Cancer · DOI

Full title: Engineering chimeric antigen receptor-T cells for cancer treatment

Authors: Ye, Baixin; Stary, Creed M.; Li, Xuejun; Qingping, Gao; Kang, Chunsheng; Xiong, Xiaoxing

Year: 2018

Venue: Molecular Cancer

DOI: https://doi.org/10.1186/s12943-018-0814-0

Paper Chimeric antigen receptor T cells: a novel therapy for solid tumors

Yu, Shengnan; Li, Anping; Liu, Qian et al. · 2017 · Journal of Hematology & Oncology · DOI

Full title: Chimeric antigen receptor T cells: a novel therapy for solid tumors

Authors: Yu, Shengnan; Li, Anping; Liu, Qian; Li, Tengfei; Yuan, Xun; Han, Xinwei; Wu, Kongming

Year: 2017

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-017-0444-9

Paper CAR-T cells and BiTEs in solid tumors: challenges and perspectives

Edeline, Julien; Houot, Roch; Marabelle, Aurélien et al. · 2021 · Journal of Hematology & Oncology · DOI

Full title: CAR-T cells and BiTEs in solid tumors: challenges and perspectives

Authors: Edeline, Julien; Houot, Roch; Marabelle, Aurélien; Alcantara, Marion

Year: 2021

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-021-01067-5

Paper PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivo

Qibin Liao; Yunyu Mao; Huan He et al. · 2020 · Biomarker Research · DOI

Full title: PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivo

Authors: Qibin Liao; Yunyu Mao; Huan He; Xiangqing Ding; Xiaoyan Zhang; Jianqing Xu

Year: 2020

Venue: Biomarker Research

DOI: https://doi.org/10.1186/s40364-020-00237-w

Paper Identification of cancer-specific cell surface targets for CAR-T cell therapy

Hosen, Naoki · 2024 · Inflammation and Regeneration · DOI

Full title: Identification of cancer-specific cell surface targets for CAR-T cell therapy

Authors: Hosen, Naoki

Year: 2024

Venue: Inflammation and Regeneration

DOI: https://doi.org/10.1186/s41232-024-00329-2

Paper Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma

Hsiang-Chi, Tseng; Xiong, Wei; Badeti, Saiaditya et al. · 2020 · Nature Communications · DOI

Full title: Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma

Year: 2020

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-020-18444-2

Paper Coopting T cell proximal signaling molecules enables Boolean logic-gated CAR T cell control

Aidan M Tousley; M. Rotiroti; Louai Labanieh et al. · 2022 · bioRxiv · DOI

Full title: Coopting T cell proximal signaling molecules enables Boolean logic-gated CAR T cell control

Authors: Aidan M Tousley; M. Rotiroti; Louai Labanieh; L. W. Rysavy; Skyler P Rietberg; Eva L. de la Serna; G. N. Dalton; D. Klysz; Evan W. Weber; Won-Ju Kim; P. Xu; E. Sotillo; A. Dunn; C. Mackall; R. Majzner

Year: 2022

Venue: bioRxiv

DOI: https://doi.org/10.1101/2022.06.17.496457

Paper Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors

Johnston, Adrian; Alicea, Gretchen M.; Lee, Cameron et al. · 2023 · DOI

Full title: Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors

Authors: Johnston, Adrian; Alicea, Gretchen M.; Lee, Cameron; Patel, Payal V.; Hanna, Eban A.; Vaz, Eduarda; Forjaz, André; Wan, Zeqi; Nair, Praful R.; Lim, Yeongseo; Chen, Tina; Du, Wenxuan; Kim, Dongjoo; Nichakawade, Tushar D.; Rebecca, Vito W.; Bonifant, Challice L.; Fan, Rong; Kiemen, Ashley; Wu, Pei‐Hsun; Wirtz, Denis

Year: 2023

DOI: https://doi.org/10.1101/2023.12.13.571595

Paper Compact Programmable Control of Protein Secretion in Mammalian Cells

Vlahos, Alexander E.; Call, Connor C.; Kadaba, Samarth E. et al. · 2023 · DOI

Full title: Compact Programmable Control of Protein Secretion in Mammalian Cells

Authors: Vlahos, Alexander E.; Call, Connor C.; Kadaba, Samarth E.; Guo, Siqi; Gao, Xiaojing

Year: 2023

DOI: https://doi.org/10.1101/2023.10.04.560774

Paper A synthetic notch (synNotch) system linking intratumoral immune-cancer cell communication to a synthetic blood biomarker assay

Fu, Yanghao; Wang, TianDuo; Ronald, John A. · 2023 · Frontiers in Pharmacology · DOI

Full title: A synthetic notch (synNotch) system linking intratumoral immune-cancer cell communication to a synthetic blood biomarker assay

Authors: Fu, Yanghao; Wang, TianDuo; Ronald, John A.

Year: 2023

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2023.1304194

Paper De novo -designed minibinders expand the synthetic biology sensing repertoire

Weinberg, Zara Y.; Soliman, Sarah S.; Kim, Matthew S. et al. · 2024 · DOI

Full title: De novo -designed minibinders expand the synthetic biology sensing repertoire

Authors: Weinberg, Zara Y.; Soliman, Sarah S.; Kim, Matthew S.; Shah, Devan H; Chen, Irene P.; Ott, Mélanie; Lim, Wendell A.; El‐Samad, Hana

Year: 2024

DOI: https://doi.org/10.1101/2024.01.12.575267

Paper Synthetic Cellular Immunity based on CAR repertoire for Human Immunotherapy

Fu, Wenyan; Wang, Chuqi; Ma, Zetong et al. · 2019 · DOI

Full title: Synthetic Cellular Immunity based on CAR repertoire for Human Immunotherapy

Authors: Fu, Wenyan; Wang, Chuqi; Ma, Zetong; Tian, Li; Lin, Fangxing; Mao, Ruixue; Lei, Changhai; Zhao, Jian; Hu, Shi

Year: 2019

DOI: https://doi.org/10.1101/868653

Paper Special Chimeric Antigen Receptor (CAR) Modifications of T Cells: A Review

Miao, Lele; Zhang, Juan; Huang, Binjie et al. · 2022 · Frontiers in Oncology · DOI

Full title: Special Chimeric Antigen Receptor (CAR) Modifications of T Cells: A Review

Authors: Miao, Lele; Zhang, Juan; Huang, Binjie; Zhang, Zhengchao; Wang, Song; Tang, Futian; Teng, Muzhou; Li, Yumin

Year: 2022

Venue: Frontiers in Oncology

DOI: https://doi.org/10.3389/fonc.2022.832765

Paper Research advances in chimeric antigen receptor-modified T-cell therapy (Review)

Luo, Yuxi; Song, Guiqin; Liang, Shichu et al. · 2021 · Experimental and Therapeutic Medicine · DOI

Full title: Research advances in chimeric antigen receptor-modified T-cell therapy (Review)

Authors: Luo, Yuxi; Song, Guiqin; Liang, Shichu; Li, Feifei; Liu, Kang

Year: 2021

Venue: Experimental and Therapeutic Medicine

DOI: https://doi.org/10.3892/etm.2021.9915

Paper Revealing Facts About CAR-T Cell Therapy

Padmanjali, Daggupati Sai; Revathi, Boyina; Jalaiah, M · 2022 · ImmunoAnalysis · DOI

Full title: Revealing Facts About CAR-T Cell Therapy

Authors: Padmanjali, Daggupati Sai; Revathi, Boyina; Jalaiah, M

Year: 2022

Venue: ImmunoAnalysis

DOI: https://doi.org/10.34172/ia.2022.06

Paper The application of prostate specific membrane antigen in CART‑cell therapy for treatment of prostate carcinoma (Review)

Ullah, Kifayat; Addai, Frank Peprah; Yu, Feng et al. · 2018 · Oncology Reports · DOI

Full title: The application of prostate specific membrane antigen in CART‑cell therapy for treatment of prostate carcinoma (Review)

Authors: Ullah, Kifayat; Addai, Frank Peprah; Yu, Feng; Shi, Haifeng

Year: 2018

Venue: Oncology Reports

DOI: https://doi.org/10.3892/or.2018.6758

Paper A long way to the battlefront: CAR T cell therapy against solid cancers

Wang, Zhicai; Chen, Wei; Zhang, Xing et al. · 2019 · Journal of Cancer · DOI

Full title: A long way to the battlefront: CAR T cell therapy against solid cancers

Authors: Wang, Zhicai; Chen, Wei; Zhang, Xing; Cai, Zhiming; Huang, Weiren

Year: 2019

Venue: Journal of Cancer

DOI: https://doi.org/10.7150/jca.30406

Paper Precise surface functionalization of PLGA particles for human T cell modulation

Hadley, Pierce; Chen, Yuanzhou; Cline, Lariana et al. · 2023 · DOI

Full title: Precise surface functionalization of PLGA particles for human T cell modulation

Authors: Hadley, Pierce; Chen, Yuanzhou; Cline, Lariana; Han, Zhiyuan; Tang, Qizhi; Huang, Xiao; Desai, Tejal A.

Year: 2023

DOI: https://doi.org/10.21203/rs.3.pex-2337/v1

Paper CHIMERIC ANTIGEN RECEPTOR FOR CHRONIC LYMPHOCYTIC LEUKEMIA - A REVIEW

Raghunathan, Kiruthiga; Devi, Parthiban Brindha · 2019 · Asian Journal of Pharmaceutical and Clinical Research · DOI

Full title: CHIMERIC ANTIGEN RECEPTOR FOR CHRONIC LYMPHOCYTIC LEUKEMIA - A REVIEW

Authors: Raghunathan, Kiruthiga; Devi, Parthiban Brindha

Year: 2019

Venue: Asian Journal of Pharmaceutical and Clinical Research

DOI: https://doi.org/10.22159/ajpcr.2018.v12i1.29642

Paper Perspectives on Chimeric Antigen Receptor T-Cell Immunotherapy for Solid Tumors

Kosti, Paris; Maher, John; Arnold, James N. · 2018 · Frontiers in Immunology · DOI

Full title: Perspectives on Chimeric Antigen Receptor T-Cell Immunotherapy for Solid Tumors

Authors: Kosti, Paris; Maher, John; Arnold, James N.

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.01104

Paper Emerging Approaches for Regulation and Control of CAR T Cells: A Mini Review

Brandt, Lærke Josefine Baunsgaard; Barnkob, Mike Bogetofte; Michaels, Yale S. et al. · 2020 · Frontiers in Immunology · DOI

Full title: Emerging Approaches for Regulation and Control of CAR T Cells: A Mini Review

Authors: Brandt, Lærke Josefine Baunsgaard; Barnkob, Mike Bogetofte; Michaels, Yale S.; Heiselberg, Julia; Barington, Torben

Year: 2020

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2020.00326

Paper Obstacles and Coping Strategies of CAR-T Cell Immunotherapy in Solid Tumors

Miao, Lele; Zhang, Zhengchao; Ren, Zhijian et al. · 2021 · Frontiers in Immunology · DOI

Full title: Obstacles and Coping Strategies of CAR-T Cell Immunotherapy in Solid Tumors

Authors: Miao, Lele; Zhang, Zhengchao; Ren, Zhijian; Tang, Futian; Li, Yumin

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.687822

Paper From barriers to novel strategies: smarter CAR T therapy hits hard to tumors

Khawar, Muhammad Babar; Ge, Fei; Afzal, Ali et al. · 2023 · Frontiers in Immunology · DOI

Full title: From barriers to novel strategies: smarter CAR T therapy hits hard to tumors

Authors: Khawar, Muhammad Babar; Ge, Fei; Afzal, Ali; Sun, Haibo

Year: 2023

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2023.1203230

Paper Targeting colorectal cancer cells using AND-gated adaptor RevCAR T-cells

Soto, Karla Elizabeth González; Loureiro, Liliana R.; Bartsch, Tabea et al. · 2023 · Frontiers in Immunology · DOI

Full title: Targeting colorectal cancer cells using AND-gated adaptor RevCAR T-cells

Authors: Soto, Karla Elizabeth González; Loureiro, Liliana R.; Bartsch, Tabea; Arndt, Claudia; Kegler, Alexandra; Mitwasi, Nicola; Drewitz, Laura; Hoffmann, Lydia; Saleh, Haidy A.; Crespo, Eugenia; Mehnert, M.; Daglar, Cansu; Abken, Hinrich; Momburg, Frank; Bachmann, Michael; Feldmann, Anja

Year: 2023

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2023.1302354

Paper Comprehensive clinical evaluation of CAR-T cell immunotherapy for solid tumors: a path moving forward or a dead end?

Drougkas, Konstantinos; Karampinos, Konstantinos; Karavolias, Ioannis et al. · 2022 · Journal of Cancer Research and Clinical Oncology · DOI

Full title: Comprehensive clinical evaluation of CAR-T cell immunotherapy for solid tumors: a path moving forward or a dead end?

Authors: Drougkas, Konstantinos; Karampinos, Konstantinos; Karavolias, Ioannis; Koumprentziotis, Ioannis‐Alexios; Ploumaki, Ioanna; Triantafyllou, Efthymios; Trontzas, Ioannis P.; Κοττέας, Ηλίας

Year: 2022

Venue: Journal of Cancer Research and Clinical Oncology

DOI: https://doi.org/10.1007/s00432-022-04547-4

Paper Treatment of solid tumors with chimeric antigen receptor-engineered T cells: current status and future prospects

Di, Shengmeng; Li, Zonghai · 2016 · Science China Life Sciences · DOI

Full title: Treatment of solid tumors with chimeric antigen receptor-engineered T cells: current status and future prospects

Authors: Di, Shengmeng; Li, Zonghai

Year: 2016

Venue: Science China Life Sciences

DOI: https://doi.org/10.1007/s11427-016-5025-6

Paper Chimeric Antigen Receptor-T Cells for Targeting Solid Tumors: Current Challenges and Existing Strategies

Springuel, Lorraine; Lonez, Caroline; Alexandre, Bertrand et al. · 2019 · BioDrugs · DOI

Full title: Chimeric Antigen Receptor-T Cells for Targeting Solid Tumors: Current Challenges and Existing Strategies

Authors: Springuel, Lorraine; Lonez, Caroline; Alexandre, Bertrand; Cutsem, Eric Van; Machiels, Jean‐Pascal; Eynde, Marc Van den; Prenen, Hans; Hendlisz, Alain; Shaza, Leila; Carrasco, Javier; Canon, Jean-Luc; Opyrchal, Mateusz; Odunsi, Kunle; Rottey, Sylvie; Gilham, David E.; Flament, Anne; Lehmann, Frédéric

Year: 2019

Venue: BioDrugs

DOI: https://doi.org/10.1007/s40259-019-00368-z

Paper Cytotoxic CD8+ T cells in cancer and cancer immunotherapy

Raskov, Hans; Orhan, Adile; Christensen, Jan Pravsgaard et al. · 2020 · British Journal of Cancer · DOI

Full title: Cytotoxic CD8+ T cells in cancer and cancer immunotherapy

Authors: Raskov, Hans; Orhan, Adile; Christensen, Jan Pravsgaard; Gögenür, Ismail

Year: 2020

Venue: British Journal of Cancer

DOI: https://doi.org/10.1038/s41416-020-01048-4

Paper New Strategies for the Treatment of Solid Tumors with CAR-T Cells

Zhang, Hao; Ye, Zhenlong; Yuan, Zhen-Gang et al. · 2016 · International Journal of Biological Sciences · DOI

Full title: New Strategies for the Treatment of Solid Tumors with CAR-T Cells

Authors: Zhang, Hao; Ye, Zhenlong; Yuan, Zhen-Gang; Luo, Zheng-qiang; Jin, Huajun; Qian, Qijun

Year: 2016

Venue: International Journal of Biological Sciences

DOI: https://doi.org/10.7150/ijbs.14405

Thesis Cancer Immunotherapy : Evolving Oncolytic viruses and CAR T-cells

Ramachandran, Mohanraj · 2016 · Uppsala University · DOI

Full title: Cancer Immunotherapy : Evolving Oncolytic viruses and CAR T-cells

Authors: Ramachandran, Mohanraj

Year: 2016

Venue: Uppsala University

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-302891

Thesis Development of mechanogenetic tools for subcellular applications in cancer immunotherapy

Pan, Yijia · 2018 · University of California, San Diego (UCSD) · DOI

Full title: Development of mechanogenetic tools for subcellular applications in cancer immunotherapy

Authors: Pan, Yijia

Year: 2018

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/1nd242wb

Thesis Molecular and Cellular Engineering to Guide CAR T Cell Therapy through the Immunosuppressive Tumor Microenvironment

Man, Chi-Wei · 2022 · University of California, San Diego (UCSD) · DOI

Full title: Molecular and Cellular Engineering to Guide CAR T Cell Therapy through the Immunosuppressive Tumor Microenvironment

Authors: Man, Chi-Wei

Year: 2022

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/2v29x1p9

Thesis Engineering Molecular Modules Through Directed Evolution for Applications in Single-Cell Imaging and Immunotherapy

Limsakul, Praopim · 2019 · University of California, San Diego (UCSD) · DOI

Full title: Engineering Molecular Modules Through Directed Evolution for Applications in Single-Cell Imaging and Immunotherapy

Authors: Limsakul, Praopim

Year: 2019

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/7x01b05n

Thesis Systems Immune Profiling Elucidates Therapeutic Vulnerabilities and Enhancements for Viral and Engineered Tumor Immunity

Burnett, Cassandra Eve · 2023 · University of California, San Francisco (UCSF) · DOI

Full title: Systems Immune Profiling Elucidates Therapeutic Vulnerabilities and Enhancements for Viral and Engineered Tumor Immunity

Authors: Burnett, Cassandra Eve

Year: 2023

Venue: University of California, San Francisco (UCSF)

DOI: https://escholarship.org/uc/item/98n328x0

Thesis Combining TIL and CAR for adoptive cell therapy in metastatic melanoma

Mills, Jane Kathleen · 2019 · University of Melbourne · DOI

Full title: Combining TIL and CAR for adoptive cell therapy in metastatic melanoma

Authors: Mills, Jane Kathleen

Year: 2019

Venue: University of Melbourne

DOI: http://hdl.handle.net/11343/228933

Thesis Understanding the role of adenosine receptor signalling in chimeric antigen receptor (CAR) T cell therapy in solid cancer

Sek, Kevin Chen Ming · 2021 · University of Melbourne · DOI

Full title: Understanding the role of adenosine receptor signalling in chimeric antigen receptor (CAR) T cell therapy in solid cancer

Authors: Sek, Kevin Chen Ming

Year: 2021

Venue: University of Melbourne

DOI: http://hdl.handle.net/11343/282479

Thesis Engineering Chimeric Antigen Receptor T Cell Therapy for Glioblastoma

Abbott, Rebecca Caitlyn · 2023 · University of Melbourne · DOI

Full title: Engineering Chimeric Antigen Receptor T Cell Therapy for Glioblastoma

Authors: Abbott, Rebecca Caitlyn

Year: 2023

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/326532

Thesis CRISPR/Cas9 Engineering of Next Generation Armoured CAR T Cells

Chen, Amanda Xi Ying · 2024 · University of Melbourne · DOI

Full title: CRISPR/Cas9 Engineering of Next Generation Armoured CAR T Cells

Authors: Chen, Amanda Xi Ying

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/339525

Thesis COMBINING IAP ANTAGONISTS WITH CAR T CELL THERAPY TO TREAT GLIOBLASTOMA: THE IAP ANTAGONIST BIRINAPANT ENHANCES CHIMERIC ANTIGEN RECEPTOR T CELL THERAPY FOR GLIOBLASTOMA BY OVERCOMING ANTIGEN HETEROGENEITY

Song, Edward, Zeyuan · 2024 · University of Pennsylvania · DOI

Full title: COMBINING IAP ANTAGONISTS WITH CAR T CELL THERAPY TO TREAT GLIOBLASTOMA: THE IAP ANTAGONIST BIRINAPANT ENHANCES CHIMERIC ANTIGEN RECEPTOR T CELL THERAPY FOR GLIOBLASTOMA BY OVERCOMING ANTIGEN HETEROGENEITY

Authors: Song, Edward, Zeyuan

Year: 2024

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/59711

Thesis Cancer Immunotherapy

Zhang, Yu · 2024 · University of Georgia - UGA Open Scholar · DOI

Full title: Cancer Immunotherapy

Authors: Zhang, Yu

Year: 2024

Venue: University of Georgia - UGA Open Scholar

DOI: https://openscholar.uga.edu/record/4772/files/ZhangYuMS-Revised.pdf

Thesis Expression of a Chimeric Coreceptor Enhances the Antitumor Immunity of CD22-Targeted CAR-T Cells

Asby, Nicholas · 2024 · University of Chicago - Knowledge@UChicago · DOI

Full title: Expression of a Chimeric Coreceptor Enhances the Antitumor Immunity of CD22-Targeted CAR-T Cells

Authors: Asby, Nicholas

Year: 2024

Venue: University of Chicago - Knowledge@UChicago

DOI: https://knowledge.uchicago.edu/record/12993/files/Dissertation.pdf

Thesis CAR T-Cell Therapy for Cancer: Latest Updates and Challenges, with a Focus on B-Lymphoid Malignancies and Selected Solid Tumours

Tang, Hiu Kwan Carolyn; email: ht8000@my.bristol.ac.uk; Wang, Bo et al. · 2023 · University of Cambridge · DOI

Full title: CAR T-Cell Therapy for Cancer: Latest Updates and Challenges, with a Focus on B-Lymphoid Malignancies and Selected Solid Tumours

Authors: Tang, Hiu Kwan Carolyn; email: ht8000@my.bristol.ac.uk; Wang, Bo; email: bw478@cam.ac.uk; Tan, Hui Xian; email: ht8000@my.bristol.ac.uk; Sarwar, Muhammad Adeel; email: ht8000@my.bristol.ac.uk; Baraka, Bahaaeldin; email: ht8000@my.bristol.ac.uk; Shafiq, Tahir; email: ht8000@my.bristol.ac.uk; Rao, Ankit R.; email: ankitrao@doctors.org.uk; email: ht8000@my.bristol.ac.uk

Year: 2023

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/354966

Thesis A decade of marketing approval of gene and cell-based therapies in the United States, European Union and Japan: An evaluation of regulatory decision-making

Coppens, D G M; de Wilde, S.; Guchelaar, H.J. et al. · 2018 · Utrecht University · DOI

Full title: A decade of marketing approval of gene and cell-based therapies in the United States, European Union and Japan: An evaluation of regulatory decision-making

Authors: Coppens, D G M; de Wilde, S.; Guchelaar, H.J.; De Bruin, M L; Leufkens, H G M; Meij, Pauline; Hoekman, J

Year: 2018

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/369040

Thesis Cellular heterogeneity mediates inherent sensitivity–specificity tradeoff in cancer targeting by synthetic circuits

Morel, Mathieu; Shtrahman, Roman; Rotter, Varda et al. · 2018 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Cellular heterogeneity mediates inherent sensitivity–specificity tradeoff in cancer targeting by synthetic circuits

Authors: Morel, Mathieu; Shtrahman, Roman; Rotter, Varda; Nissim, Lior; Bar-Ziv, Roy H.

Year: 2018

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/115130

Thesis Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses

Cho, Jang Hwan; Collins, James J; Wong, Wilson W · 2021 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses

Authors: Cho, Jang Hwan; Collins, James J; Wong, Wilson W

Year: 2021

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/135450

Thesis Visualization of the Underlying Kinetics of LckY394F and its Applications in CAR T-cell Therapy

Wei, Jiaming · 2019 · University of California, San Diego (UCSD) · DOI

Full title: Visualization of the Underlying Kinetics of LckY394F and its Applications in CAR T-cell Therapy

Authors: Wei, Jiaming

Year: 2019

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/3286n8r2

Thesis Developing thermo-activatable genetic circuits for immunotherapy

SONG, CHUNYANG · 2022 · University of California, San Diego (UCSD) · DOI

Full title: Developing thermo-activatable genetic circuits for immunotherapy

Authors: SONG, CHUNYANG

Year: 2022

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/9kb2590t

Thesis A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

Giordano-Attianese, Greta; Gainza, Pablo; Gray-Gaillard, Elise et al. · 2020 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

Authors: Giordano-Attianese, Greta; Gainza, Pablo; Gray-Gaillard, Elise; Cribioli, Elisabetta; Shui, Sailan; Kim, Seonghoon; Kwak, Mi-Jeong; Vollers, Sabrina; Osorio, Angel De Jesus Corria; Reichenbach, Patrick; Bonet, Jaume; Oh, Byung-Ha; Irving, Melita; Coukos, George; Correia, Bruno E.

Year: 2020

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/166849

Thesis Novel high-affinity EGFRvIII-specific chimeric antigen receptor T cells effectively eliminate human glioblastoma

Abbott, RC; Verdon, DJ; Gracey, FM et al. · 2021 · University of Melbourne · DOI

Full title: Novel high-affinity EGFRvIII-specific chimeric antigen receptor T cells effectively eliminate human glioblastoma

Authors: Abbott, RC; Verdon, DJ; Gracey, FM; Hughes-Parry, HE; Iliopoulos, M; Watson, KA; Mulazzani, M; Luong, K; D’Arcy, C; Sullivan, LC; Kiefel, BR; Cross, RS; Jenkins, MR

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/278219

Thesis To go or not to go? Biological logic gating engineered T cells

Abbott, RC; Hughes-Parry, HE; Jenkins, MR · 2022 · University of Melbourne · DOI

Full title: To go or not to go? Biological logic gating engineered T cells

Authors: Abbott, RC; Hughes-Parry, HE; Jenkins, MR

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/307209

Thesis Cancer Signals-Triggered T Cell Immunotherapy for Solid Tumors

Nguyen, Huong Thi Xuan · 2022 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Cancer Signals-Triggered T Cell Immunotherapy for Solid Tumors

Authors: Nguyen, Huong Thi Xuan

Year: 2022

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=case1662724663164312

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Metadata only

Paper Co-opting signalling molecules enables logic-gated control of CAR T cells

Aidan M Tousley; M. Rotiroti; Louai Labanieh et al. · 2023 · Nature · DOI

Full title: Co-opting signalling molecules enables logic-gated control of CAR T cells

Authors: Aidan M Tousley; M. Rotiroti; Louai Labanieh; L. W. Rysavy; Won-Ju Kim; C. Lareau; E. Sotillo; Evan W. Weber; Skyler P Rietberg; G. N. Dalton; Yajie Yin; D. Klysz; Peng Xu; Eva L. de la Serna; A. Dunn; Ansuman T. Satpathy; C. Mackall; R. Majzner

Year: 2023

Venue: Nature

DOI: https://doi.org/10.1038/s41586-023-05778-2

Paper Activation-inducible CAR expression enables precise control over engineered CAR T cell function

Fraessle, Simon P.; Tschulik, Claudia; Effenberger, Manuel et al. · 2023 · Communications Biology · DOI

Full title: Activation-inducible CAR expression enables precise control over engineered CAR T cell function

Authors: Fraessle, Simon P.; Tschulik, Claudia; Effenberger, Manuel; Cletiu, Vlad; Gerget, Maria; Schober, Kilian; Busch, Dirk H.; Germeroth, Lothar; Stemberger, Christian; Poltorak, Mateusz P.

Year: 2023

Venue: Communications Biology

DOI: https://doi.org/10.1038/s42003-023-04978-w

Paper LINKing signaling domains to enhance CAR T cells

Philip Bucher; J. Feucht · 2023 · Nature Cancer · DOI

Full title: LINKing signaling domains to enhance CAR T cells

Authors: Philip Bucher; J. Feucht

Year: 2023

Venue: Nature Cancer

DOI: https://doi.org/10.1038/s43018-023-00538-7

Paper DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation

Xiao Huang; Jasper Z. Williams; Ryan Chang et al. · 2020 · Nature Nanotechnology · DOI

Full title: DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation

Authors: Xiao Huang; Jasper Z. Williams; Ryan Chang; Zhongbo Li; Cassandra E. Burnett; R. Hernandez-Lopez; Initha Setiady; Eric Gai; David M. Patterson; Wei Yu; Kole T. Roybal; W. Lim; T. Desai

Year: 2020

Venue: Nature Nanotechnology

DOI: https://doi.org/10.1038/s41565-020-00813-z

Paper Dual-inhibitory domain iCARs improve the efficiency of the AND-NOT gate CAR T strategy

Nathanael J. Bangayan; Liang Wang; Giselle Burton Sojo et al. · 2023 · Proceedings of the National Academy of Sciences of the United States of America · DOI

Full title: Dual-inhibitory domain iCARs improve the efficiency of the AND-NOT gate CAR T strategy

Authors: Nathanael J. Bangayan; Liang Wang; Giselle Burton Sojo; Miyako Noguchi; D. Cheng; Lisa Ta; Donny Gunn; Zhiyuan Mao; Shiqin Liu; Qingqing Yin; M. Riedinger; Keyu Li; Anna M. Wu; Tanya Stoyanova; Owen N. Witte

Year: 2023

Venue: Proceedings of the National Academy of Sciences of the United States of America

DOI: https://doi.org/10.1073/pnas.2312374120

Paper OC41 - Glucocorticoid inhibition enables mono- and bispecific CAR-T cells to overcome immunotherapeutic resistance in adrenocortical carcinoma

M. Schauer; A. Stabile; P. Spieler et al. · 2025 · European Journal of Endocrinology · DOI

Full title: OC41 - Glucocorticoid inhibition enables mono- and bispecific CAR-T cells to overcome immunotherapeutic resistance in adrenocortical carcinoma

Authors: M. Schauer; A. Stabile; P. Spieler; J. Weber; B. Altieri; L. Landwehr; M. Fassnacht; M. Hudecek

Year: 2025

Venue: European Journal of Endocrinology

DOI: https://doi.org/10.1093/ejendo/lvaf168.078

Paper IMMU-74. Novel screening method to identify potent immune-inspired inhibitors for NOT-gated CAR T cells to suppress on-target-off-tumor toxicity in brain tumors

Bhairavy J Puviindran; Aditya Mohan; Rushil Yerrabelli et al. · 2025 · Neuro-Oncology · DOI

Full title: IMMU-74. Novel screening method to identify potent immune-inspired inhibitors for NOT-gated CAR T cells to suppress on-target-off-tumor toxicity in brain tumors

Authors: Bhairavy J Puviindran; Aditya Mohan; Rushil Yerrabelli; Ariel Gonzalez; Charla Gentry; E. Blandford; Daniel S. Wilkinson; P. Fecci; Anoop Patel

Year: 2025

Venue: Neuro-Oncology

DOI: https://doi.org/10.1093/neuonc/noaf201.0872

Paper Novel Approaches to Enhance the Specificity and Safety of Engineered T Cells

V. D. Fedorov; M. Sadelain; Christopher C. Kloss · 2014 · Cancer Journal · DOI

Full title: Novel Approaches to Enhance the Specificity and Safety of Engineered T Cells

Authors: V. D. Fedorov; M. Sadelain; Christopher C. Kloss

Year: 2014

Venue: Cancer Journal

DOI: https://doi.org/10.1097/ppo.0000000000000040

Paper Figure 2 from Programming CAR T Cell Tumor Recognition: Tuned Antigen Sensing and Logic Gating

Hamieh, Mohamad; Mansilla‐Soto, Jorge; Rivière, Isabelle et al. · 2023 · DOI

Full title: Figure 2 from Programming CAR T Cell Tumor Recognition: Tuned Antigen Sensing and Logic Gating

Authors: Hamieh, Mohamad; Mansilla‐Soto, Jorge; Rivière, Isabelle; Sadelain, Michel

Year: 2023

DOI: https://doi.org/10.1158/2159-8290.23506865

Paper Figure 2 from Programming CAR T Cell Tumor Recognition: Tuned Antigen Sensing and Logic Gating

Hamieh, Mohamad; Mansilla‐Soto, Jorge; Rivière, Isabelle et al. · 2023 · DOI

Full title: Figure 2 from Programming CAR T Cell Tumor Recognition: Tuned Antigen Sensing and Logic Gating

Authors: Hamieh, Mohamad; Mansilla‐Soto, Jorge; Rivière, Isabelle; Sadelain, Michel

Year: 2023

DOI: https://doi.org/10.1158/2159-8290.23506865

Paper Logic-Gated CAR T Cells Enhance Survival and Reduce On-Target Toxicity.

· 2023 · Cancer Discovery · DOI

Full title: Logic-Gated CAR T Cells Enhance Survival and Reduce On-Target Toxicity.

Year: 2023

Venue: Cancer Discovery

DOI: https://doi.org/10.1158/2159-8290.cd-rw2023-043

Paper Engineering Principles for Synthetic Biology Circuits in Cancer Immunotherapy

Shih, Ryan M.; Chen, Yvonne Y. · 2022 · Cancer Immunology Research · DOI

Full title: Engineering Principles for Synthetic Biology Circuits in Cancer Immunotherapy

Authors: Shih, Ryan M.; Chen, Yvonne Y.

Year: 2022

Venue: Cancer Immunology Research

DOI: https://doi.org/10.1158/2326-6066.cir-21-0769

Paper Programming CAR T Cell Tumor Recognition: Tuned Antigen Sensing and Logic Gating

Hamieh, Mohamad; Mansilla‐Soto, Jorge; Rivière, Isabelle et al. · 2023 · Cancer Discovery · DOI

Full title: Programming CAR T Cell Tumor Recognition: Tuned Antigen Sensing and Logic Gating

Authors: Hamieh, Mohamad; Mansilla‐Soto, Jorge; Rivière, Isabelle; Sadelain, Michel

Year: 2023

Venue: Cancer Discovery

DOI: https://doi.org/10.1158/2159-8290.cd-23-0101

Paper Insight into next-generation CAR therapeutics: designing CAR T cells to improve clinical outcomes

Roselli, Emiliano; Faramand, Rawan; Davila, Marco L. · 2021 · Journal of Clinical Investigation · DOI

Full title: Insight into next-generation CAR therapeutics: designing CAR T cells to improve clinical outcomes

Authors: Roselli, Emiliano; Faramand, Rawan; Davila, Marco L.

Year: 2021

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci142030

Paper Hurdles to breakthrough in CAR T cell therapy of solid tumors

Marofi, Faroogh; Achmad, Harun; Bokov, Dmitry Olegovich et al. · 2022 · Stem Cell Research & Therapy · DOI

Full title: Hurdles to breakthrough in CAR T cell therapy of solid tumors

Authors: Marofi, Faroogh; Achmad, Harun; Bokov, Dmitry Olegovich; Abdelbasset, Walid Kamal; Alsadoon, Zeid; Chupradit, Supat; Suksatan, Wanich; Shariatzadeh, Siavash; Hasanpoor, Zahra; Yazdanifar, Mahboubeh; Shomali, Navid; Khiavi, Farhad Motavalli

Year: 2022

Venue: Stem Cell Research & Therapy

DOI: https://doi.org/10.1186/s13287-022-02819-x

Paper Prospective BASECAMP-1 experience in patients with gastrointestinal (GI) cancer: Identifying patients with human leukocyte antigen (HLA) loss of heterozygosity (LOH) for a future therapeutic trial exploiting LOH as a tumor vulnerability.

J. Hecht; S. Kopetz; Theodore H. Welling et al. · 2023 · Journal of Clinical Oncology · DOI

Full title: Prospective BASECAMP-1 experience in patients with gastrointestinal (GI) cancer: Identifying patients with human leukocyte antigen (HLA) loss of heterozygosity (LOH) for a future therapeutic trial exploiting LOH as a tumor vulnerability.

Authors: J. Hecht; S. Kopetz; Theodore H. Welling; M. Morelli; J. Molina; K. Kirtane; P. Oberstein; D. Greenwald; Yi Lin; A. Mardiros; K. Beutner; Ariane Lozac’hmeur; A. Salahudeen; Kirstin B. Liechty; Judy Vong; E. Ng; D. Maloney; W. Go; J. Welch; D. Simeone

Year: 2023

Venue: Journal of Clinical Oncology

DOI: https://doi.org/10.1200/jco.2023.41.4_suppl.209

Paper BASECAMP-1: An approach to improve patient screening efficiency and to provide large datasets for precision medicine clinical trials.

K. Spencer; M. Ulrickson; P. Grierson et al. · 2025 · Journal of Clinical Oncology · DOI

Full title: BASECAMP-1: An approach to improve patient screening efficiency and to provide large datasets for precision medicine clinical trials.

Authors: K. Spencer; M. Ulrickson; P. Grierson; S. P. Patel; J. Specht; Jong Chul Park; Hemant S. Murthy; Diane M. Simeone; M. P. Morelli; D. Maloney; M. Maus; Wen-Kai Weng; C. Eng; Kai He; Brittany Waschke; E. Ng; Jessica Tebbets; K. Kirtane; J. R. Hecht; J. R. Molina

Year: 2025

Venue: Journal of Clinical Oncology

DOI: https://doi.org/10.1200/jco.2025.43.16_suppl.e23020

Paper Next generation sequencing (NGS) to identify relapsed gastrointestinal (GI) solid tumor patients with human leukocyte antigen (HLA) loss of heterozygosity (LOH) for future logic-gated CAR T therapy to reduce on target off tumor toxicity.

J. R. Hecht; S. Kopetz; S. P. Patel et al. · 2022 · Journal of Clinical Oncology · DOI

Full title: Next generation sequencing (NGS) to identify relapsed gastrointestinal (GI) solid tumor patients with human leukocyte antigen (HLA) loss of heterozygosity (LOH) for future logic-gated CAR T therapy to reduce on target off tumor toxicity.

Authors: J. R. Hecht; S. Kopetz; S. P. Patel; Theodore H. Welling; M. P. Morelli; M. Borad; J. R. Molina; K. Kirtane; Yi Lin; Michelle Fan-Port; A. Mardiros; Karl Beutner; Ariane Lozac’hmeur; D. Lau; Kirstin B. Liechty; Judy Vong; E. Ng; D. Maloney; W. Y. Go; Diane M. Simeone

Year: 2022

Venue: Journal of Clinical Oncology

DOI: https://doi.org/10.1200/jco.2022.40.4_suppl.190

Paper Chimeric-antigen receptor T (CAR-T) cell therapy for solid tumors: challenges and opportunities

Xia, Anliang; Wang, Xiaochen; Lu, Yijun et al. · 2017 · Oncotarget · DOI

Full title: Chimeric-antigen receptor T (CAR-T) cell therapy for solid tumors: challenges and opportunities

Authors: Xia, Anliang; Wang, Xiaochen; Lu, Yijun; Lu, Xiaojie; Sun, Beicheng

Year: 2017

Venue: Oncotarget

DOI: https://doi.org/10.18632/oncotarget.19361

Paper Design and characterization of multiplex gene-edited CAR-T cells resistant to orthogonal immunosuppressive pathways within the solid tumor microenvironment

Murray, Ryan · 2024 · DOI

Full title: Design and characterization of multiplex gene-edited CAR-T cells resistant to orthogonal immunosuppressive pathways within the solid tumor microenvironment

Authors: Murray, Ryan

Year: 2024

DOI: https://doi.org/10.17760/d20653008

Paper CAR density influences antitumoral efficacy of BCMA CAR T cells and correlates with clinical outcome

Rodríguez-Márquez, Paula; Calleja-Cervantes, María Eréndira; Serrano, Guillermo et al. · 2022 · Science Advances · DOI

Full title: CAR density influences antitumoral efficacy of BCMA CAR T cells and correlates with clinical outcome

Authors: Rodríguez-Márquez, Paula; Calleja-Cervantes, María Eréndira; Serrano, Guillermo; Oliver‐Caldés, Aina; Palacios‐Berraquero, María Luisa; Martín-Mallo, Ángel; Calviño, Cristina; Español‐Rego, Marta; Ceballos, Candela; Lozano, Teresa; Martín‐Úriz, Patxi San; Vilas‐Zornoza, Amaia; Rodríguez-Diaz, Saray; Martínez-Turrillas, Rebeca; Jáuregui, Patricia; Alignani, Diego; Viguria, María C.; Redondo, Margarita; Pascal, Mariona; Martín-Antonio, Beatriz; Juan, Manel; Urbano-Ispizúa, Álvaro; Rodríguez‐Otero, Paula; Piérola, Ana Alfonso; Paiva, Bruno; Lasarte, Juan José; Inogés, Susana; Cerio, Ascensión López-Dı́az de; Miguel, Jesús F. San; Larrea, Carlos Fernández de; Hernáez, Mikel; Rodríguez-Madoz, Juan R.; Prósper, Felipe

Year: 2022

Venue: Science Advances

DOI: https://doi.org/10.1126/sciadv.abo0514

Paper Coengineering specificity, safety, and function into T cells for cancer immunotherapy

Attianese, Greta Maria Paola Giordano; Ash, Sarah; Irving, Melita · 2023 · Immunological Reviews · DOI

Full title: Coengineering specificity, safety, and function into T cells for cancer immunotherapy

Authors: Attianese, Greta Maria Paola Giordano; Ash, Sarah; Irving, Melita

Year: 2023

Venue: Immunological Reviews

DOI: https://doi.org/10.1111/imr.13252

Paper Next‐generation chimeric antigen receptors for T‐ and natural killer‐cell therapies against cancer

Li, Ye; Rezvani, Katayoun; Rafei, Hind · 2023 · Immunological Reviews · DOI

Full title: Next‐generation chimeric antigen receptors for T‐ and natural killer‐cell therapies against cancer

Authors: Li, Ye; Rezvani, Katayoun; Rafei, Hind

Year: 2023

Venue: Immunological Reviews

DOI: https://doi.org/10.1111/imr.13255

Paper Toward the clinical development of synthetic immunity to cancer

Garcia, Julie; Burnett, Cassandra E.; Roybal, Kole T. · 2023 · Immunological Reviews · DOI

Full title: Toward the clinical development of synthetic immunity to cancer

Authors: Garcia, Julie; Burnett, Cassandra E.; Roybal, Kole T.

Year: 2023

Venue: Immunological Reviews

DOI: https://doi.org/10.1111/imr.13245

Paper T cell circuits that sense antigen density with an ultrasensitive threshold

Hernández‐López, Rogelio A.; Yu, Wei; Cabral, Katelyn A. et al. · 2021 · Science · DOI

Full title: T cell circuits that sense antigen density with an ultrasensitive threshold

Year: 2021

Venue: Science

DOI: https://doi.org/10.1126/science.abc1855

Paper The Great Debate at ‘Immunotherapy Bridge’, Naples, December 5, 2019

Ascierto, Paolo A.; Bifulco, Carlo; Galon, Jerome et al. · 2020 · Journal for ImmunoTherapy of Cancer · DOI

Full title: The Great Debate at ‘Immunotherapy Bridge’, Naples, December 5, 2019

Authors: Ascierto, Paolo A.; Bifulco, Carlo; Galon, Jerome; Garbe, Claus; Khleif, Samir N.; McQuade, Jennifer L.; Odunsi, Kunle; Okada, Hideho; Paulos, Chrystal M.; Quezada, Sergio A.; Tawbi, Hussein A.; Timmerman, John M.; Trinchieri, Giorgio; Butterfield, Lisa H.; Puzanov, Igor

Year: 2020

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2020-000921

Paper Microenvironment actuated CAR T cells improve solid tumor efficacy without toxicity

Vogt, Kristen; Silberman, Pedro C.; Lin, Qianqian et al. · 2025 · Science Advances · DOI

Full title: Microenvironment actuated CAR T cells improve solid tumor efficacy without toxicity

Authors: Vogt, Kristen; Silberman, Pedro C.; Lin, Qianqian; Han, James E.; Laflin, Amy D.; Gellineau, Hendryck A.; Heller, Daniel A.; Scheinberg, David A.

Year: 2025

Venue: Science Advances

DOI: https://doi.org/10.1126/sciadv.ads3403

Paper Conditioned CAR-T cells by hypoxia-inducible transcription amplification (HiTA) system significantly enhances systemic safety and retains antitumor efficacy

He, Huan; Liao, Qibin; Zhao, Chen et al. · 2021 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Conditioned CAR-T cells by hypoxia-inducible transcription amplification (HiTA) system significantly enhances systemic safety and retains antitumor efficacy

Authors: He, Huan; Liao, Qibin; Zhao, Chen; Zhu, Cuisong; Feng, Meiqi; Liu, Zhuoqun; Jiang, Lang; Zhang, Linxia; Ding, Xiangqing; Yuan, Min; Zhang, Xiaoyan; Xu, Jianqing

Year: 2021

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2021-002755

Paper Mesothelin-specific CAR-T cell therapy that incorporates an HLA-gated safety mechanism selectively kills tumor cells

Tokatlian, Talar; Asuelime, Grace E.; Mock, Jee‐Young et al. · 2022 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Mesothelin-specific CAR-T cell therapy that incorporates an HLA-gated safety mechanism selectively kills tumor cells

Authors: Tokatlian, Talar; Asuelime, Grace E.; Mock, Jee‐Young; DiAndreth, Breanna; Sharma, Shruti; Warshaviak, Dora Toledo; Daris, Mark; Bolanos, Kristian; Luna, Breanna L.; Naradikian, Martin S.; Deshmukh, Kiran; Hamburger, Agnes E.; Kamb, Alexander

Year: 2022

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2021-003826

Paper 77 An NGS assay to identify HLA loss of heterozygosity for future CEA and MSLN logic-gated CAR-T solid tumor protocols designed for reduced on-target, off-tumor toxicity

S. Kopetz; M. Morelli; J. Molina et al. · 2022 · Regular and Young Investigator Award Abstracts · DOI

Full title: 77 An NGS assay to identify HLA loss of heterozygosity for future CEA and MSLN logic-gated CAR-T solid tumor protocols designed for reduced on-target, off-tumor toxicity

Authors: S. Kopetz; M. Morelli; J. Molina; D. Simeone; J. Randolph Hecht; K. Kirtane; M. Borad; Theodore H. Welling; E. Garon; A. Mardiros; Xueyin Wang; E. Ng; Tyler Danek; S. Gallagher; Ariane Lozac’hmeur; K. Beutner; J. Welch; D. Maloney; William Go; S. Patel

Year: 2022

Venue: Regular and Young Investigator Award Abstracts

DOI: https://doi.org/10.1136/jitc-2022-sitc2022.0077

Paper Adoptive cellular therapy in solid tumor malignancies: review of the literature and challenges ahead

Kirtane, Kedar; Elmariah, Hany; Chung, Christine H. et al. · 2021 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Adoptive cellular therapy in solid tumor malignancies: review of the literature and challenges ahead

Authors: Kirtane, Kedar; Elmariah, Hany; Chung, Christine H.; Abate‐Daga, Daniel

Year: 2021

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2021-002723

Paper 280 Novel AND-gated LINK CAR-T cells demonstrate improved safety compared to 2nd-generation CAIX CAR-T cells for the treatment of clear cell renal cell carcinoma

Larson, Rebecca C.; Sutton, Janette; Wheeler, Zeynep C et al. · 2024 · Regular and Young Investigator Award Abstracts · DOI

Full title: 280 Novel AND-gated LINK CAR-T cells demonstrate improved safety compared to 2nd-generation CAIX CAR-T cells for the treatment of clear cell renal cell carcinoma

Authors: Larson, Rebecca C.; Sutton, Janette; Wheeler, Zeynep C; Hasegawa, Kazuteru; Cudia, Darryl; Purandare, Bhamini; Studebaker, Brendan; Zhang, Shihong; Bauer, Benjamin B.; Farrell, Colin; McBroome, Jakob; Estellés, Angeles; Smith, B.; Bankovich, Alexander J.; Vargas, Diego A.; Lin, Regina

Year: 2024

Venue: Regular and Young Investigator Award Abstracts

DOI: https://doi.org/10.1136/jitc-2024-sitc2024.0280

Paper HER2 and HLA-A*02 dual CAR-T cells utilize LOH in a NOT logic gate to address on-target off-tumor toxicity

D. Bassan; L. Weinberger; Ja-Yeon Yi et al. · 2023 · Journal for ImmunoTherapy of Cancer · DOI

Full title: HER2 and HLA-A*02 dual CAR-T cells utilize LOH in a NOT logic gate to address on-target off-tumor toxicity

Authors: D. Bassan; L. Weinberger; Ja-Yeon Yi; Tanya Kim; Michael R Weist; G. Adams; O. Foord; N. Chaim; S. Tabak; N. Bujanover; Yael Lopesco; Kristina Vucci; Caitlin Schnair; Limor Levy-Knafo; R. Kendall; F. Calzone; Adi Sharbi-Yunger

Year: 2023

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2023-007426

Paper To go or not to go? Biological logic gating engineered T cells

Abbott, Rebecca C; Hughes‐Parry, Hannah E; Jenkins, Misty R. · 2022 · Journal for ImmunoTherapy of Cancer · DOI

Full title: To go or not to go? Biological logic gating engineered T cells

Authors: Abbott, Rebecca C; Hughes‐Parry, Hannah E; Jenkins, Misty R.

Year: 2022

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2021-004185

Paper Engineering single-vector logic-gated CAR T cells with transgene sizes beyond current limitations

P. Rommel; N. Engel; J.K. Malachowski et al. · 2026 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Engineering single-vector logic-gated CAR T cells with transgene sizes beyond current limitations

Authors: P. Rommel; N. Engel; J.K. Malachowski; Divanshu Shukla; Isabella R Hodson; Donna Gonzales; J. C. van der Loo; R. Young; James L Riley; Bruce L. Levine; Carl H. June

Year: 2026

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2025-012318

Paper Engineering Next-Generation CAR-T Cells: Overcoming Tumor Hypoxia and Metabolism

Gao, Torahito A.; Chen, Yvonne Y. · 2022 · Annual Review of Chemical and Biomolecular Engineering · DOI

Full title: Engineering Next-Generation CAR-T Cells: Overcoming Tumor Hypoxia and Metabolism

Authors: Gao, Torahito A.; Chen, Yvonne Y.

Year: 2022

Venue: Annual Review of Chemical and Biomolecular Engineering

DOI: https://doi.org/10.1146/annurev-chembioeng-092120-092914

Paper 589 BASECAMP-1 is an efficient pre-screening study that identifies patients with HLA LOH and provides mutational, RNA-Seq, and microbiome data for precision logic-gated CAR T therapeutic trials

J. Molina; Diane M. Simeone; K. Spencer et al. · 2024 · Regular and Young Investigator Award Abstracts · DOI

Full title: 589 BASECAMP-1 is an efficient pre-screening study that identifies patients with HLA LOH and provides mutational, RNA-Seq, and microbiome data for precision logic-gated CAR T therapeutic trials

Authors: J. Molina; Diane M. Simeone; K. Spencer; Patrick M Grierson; M. Ulrickson; K. Kirtane; M. P. Morelli; Jennifer Specht; Saurabh Dahiya; Hemant S. Murthy; Jong Chul Park; W. Y. Go; S. P. Patel; A. Mardiros; Marwan G Fakih; Jessica Tebbets; Marco Davila; Kirstin B. Liechty; M. Maus; E. Ng; D. Maloney; J. Welch; J. Randolph Hecht

Year: 2024

Venue: Regular and Young Investigator Award Abstracts

DOI: https://doi.org/10.1136/jitc-2024-sitc2024.0589

Paper Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities

Roybal, Kole T.; Lim, Wendell A. · 2017 · Annual Review of Immunology · DOI

Full title: Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities

Authors: Roybal, Kole T.; Lim, Wendell A.

Year: 2017

Venue: Annual Review of Immunology

DOI: https://doi.org/10.1146/annurev-immunol-051116-052302

Paper Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects

Guo, Yelei; Wang, Yao; Han, Weidong · 2016 · Journal of Immunology Research · DOI

Full title: Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects

Authors: Guo, Yelei; Wang, Yao; Han, Weidong

Year: 2016

Venue: Journal of Immunology Research

DOI: https://doi.org/10.1155/2016/3850839

Paper Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials

Esensten, Jonathan H.; Bluestone, Jeffrey A.; Lim, Wendell A. · 2016 · Annual Review of Pathology Mechanisms of Disease · DOI

Full title: Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials

Authors: Esensten, Jonathan H.; Bluestone, Jeffrey A.; Lim, Wendell A.

Year: 2016

Venue: Annual Review of Pathology Mechanisms of Disease

DOI: https://doi.org/10.1146/annurev-pathol-052016-100304

Paper CAR‐T Cell Therapy in Cancer: Tribulations and Road Ahead

Zhang, Qingyang; Ping, Jieming; Huang, Zirui et al. · 2020 · Journal of Immunology Research · DOI

Full title: CAR‐T Cell Therapy in Cancer: Tribulations and Road Ahead

Authors: Zhang, Qingyang; Ping, Jieming; Huang, Zirui; Zhang, Xiaoli; Zhou, Jingyi; Wang, Gangyang; Shaoyang, Liu; Ma, Jianjun

Year: 2020

Venue: Journal of Immunology Research

DOI: https://doi.org/10.1155/2020/1924379

Paper Chimeric Antigen Receptor‐T (CAR‐T) Cells as “<i>Living Drugs</i>”: A Clinical Pharmacist Perspective

Murnane, Ciara; Gardiner, N.; Crehan, Olga et al. · 2024 · Journal of Clinical Pharmacy and Therapeutics · DOI

Full title: Chimeric Antigen Receptor‐T (CAR‐T) Cells as “<i>Living Drugs</i>”: A Clinical Pharmacist Perspective

Authors: Murnane, Ciara; Gardiner, N.; Crehan, Olga; Bacon, Christopher L.; McHugh, Ronan; Gilmer, John F.; Mantalaris, Athanasios; Panoskaltsis, Nicki

Year: 2024

Venue: Journal of Clinical Pharmacy and Therapeutics

DOI: https://doi.org/10.1155/2024/2239888

Paper CAR T Cell Therapy for Solid Tumors

Newick, Kheng; O’Brien, Shaun; Moon, Edmund K. et al. · 2016 · Annual Review of Medicine · DOI

Full title: CAR T Cell Therapy for Solid Tumors

Authors: Newick, Kheng; O’Brien, Shaun; Moon, Edmund K.; Albelda, Steven Μ.

Year: 2016

Venue: Annual Review of Medicine

DOI: https://doi.org/10.1146/annurev-med-062315-120245

Paper Data from Efficacy and Safety of Glycosphingolipid SSEA-4 Targeting CAR-T Cells in an Ovarian Carcinoma Model

Monzó, Héctor J.; Kalander, Kerttu; Hyytiäinen, Marko et al. · 2023 · DOI

Full title: Data from Efficacy and Safety of Glycosphingolipid SSEA-4 Targeting CAR-T Cells in an Ovarian Carcinoma Model

Authors: Monzó, Héctor J.; Kalander, Kerttu; Hyytiäinen, Marko; Elbasani, Endrit; Wall, Johanna; Moyano‐Galceran, Lidia; Ramanathan, Jayendrakishore Tanjore; Jukonen, Joonas; Laakkonen, Pirjo; Ristimäki, Ari; Carlson, Joseph W.; Lehti, Kaisa; Salehi, Sahar; Puolakkainen, Pauli; Haglund, Caj; Seppänen, Hanna; Leppä, Sirpa; Ojala, Päivi M.

Year: 2023

DOI: https://doi.org/10.1158/1535-7163.c.6908585.v1

Paper Abstract LB092: Identification of target antigens for logic-gated CAR-T therapeutics for the treatment of clear cell renal cell carcinoma: conditional targeting of CA9 with a PSMA PrimeR

Nickolas Attanasio; Levi Gray-Rupp; Stanley Zhou et al. · 2023 · Cancer Research · DOI

Full title: Abstract LB092: Identification of target antigens for logic-gated CAR-T therapeutics for the treatment of clear cell renal cell carcinoma: conditional targeting of CA9 with a PSMA PrimeR

Authors: Nickolas Attanasio; Levi Gray-Rupp; Stanley Zhou; Samuel A. Williams

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2023-lb092

Paper Abstract 6118: Engineering p95HER2 CAR T cells for the treatment of HER2-positive tumors

Ariadna Grinyó-Escuer; Marta Bort-Brusca; Pablo Ovejero et al. · 2025 · Cancer Research · DOI

Full title: Abstract 6118: Engineering p95HER2 CAR T cells for the treatment of HER2-positive tumors

Authors: Ariadna Grinyó-Escuer; Marta Bort-Brusca; Pablo Ovejero; Julia Fernandez Torrente; Judit Gago; Marta Escorihuela; Macarena Román; Joaquin Arribas

Year: 2025

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2025-6118

Paper Geometric parameters that affect the behavior of logic-gated CAR T cells

Alexander Partin; Richele Bruno; S. Shafaattalab et al. · 2024 · Frontiers in Immunology · DOI

Full title: Geometric parameters that affect the behavior of logic-gated CAR T cells

Authors: Alexander Partin; Richele Bruno; S. Shafaattalab; Erica Vander Mause; Aaron G. Winters; M. Daris; Casey Gahrs; C. A. Jette; B. DiAndreth; Mark L. Sandberg; A. Hamburger; Alexander Kamb; T. P. Riley

Year: 2024

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2024.1304765

Paper Current strategies for armoring chimeric antigen receptor T-cells to overcome barriers of the solid tumor microenvironment

Yang, Dorothy; Macmorland, William; Arnold, James N. · 2025 · Frontiers in Immunology · DOI

Full title: Current strategies for armoring chimeric antigen receptor T-cells to overcome barriers of the solid tumor microenvironment

Authors: Yang, Dorothy; Macmorland, William; Arnold, James N.

Year: 2025

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2025.1643941

Paper Data Sheet 1_Current strategies for armoring chimeric antigen receptor T-cells to overcome barriers of the solid tumor microenvironment.pdf

(22229194), Dorothy D. Yang; (22136605), William Macmorland; (2217103), James N. Arnold · 2025 · Figshare · DOI

Full title: Data Sheet 1_Current strategies for armoring chimeric antigen receptor T-cells to overcome barriers of the solid tumor microenvironment.pdf

Authors: (22229194), Dorothy D. Yang; (22136605), William Macmorland; (2217103), James N. Arnold

Year: 2025

Venue: Figshare

DOI: https://doi.org/10.3389/fimmu.2025.1643941.s001

Paper Alternative CAR Therapies: Recent Approaches in Engineering Chimeric Antigen Receptor Immune Cells to Combat Cancer

Moreno, Carlos M.; Haynie, Christopher; Cheever, Abigail et al. · 2022 · Biomedicines · DOI

Full title: Alternative CAR Therapies: Recent Approaches in Engineering Chimeric Antigen Receptor Immune Cells to Combat Cancer

Authors: Moreno, Carlos M.; Haynie, Christopher; Cheever, Abigail; Weber, K. Scott

Year: 2022

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines10071493

Paper A synthetic notch (synNotch) system linking intratumoral immune-cancer cell communication to a synthetic blood biomarker assay

Fu, Yanghao; Wang, TianDuo; Ronald, John A. · 2023 · Frontiers in Pharmacology · DOI

Full title: A synthetic notch (synNotch) system linking intratumoral immune-cancer cell communication to a synthetic blood biomarker assay

Authors: Fu, Yanghao; Wang, TianDuo; Ronald, John A.

Year: 2023

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2023.1304194

Paper Potential Application of Chimeric Antigen Receptor (CAR)-T Cell Therapy in Renal Cell Tumors

Schepisi, Giuseppe; Conteduca, Vincenza; Casadei, Chiara et al. · 2020 · Frontiers in Oncology · DOI

Full title: Potential Application of Chimeric Antigen Receptor (CAR)-T Cell Therapy in Renal Cell Tumors

Authors: Schepisi, Giuseppe; Conteduca, Vincenza; Casadei, Chiara; Gurioli, Giorgia; Rossi, Lorena; Gallá, Valentina; Cursano, Maria Concetta; Brighi, Nicole; Lolli, Cristian; Menna, Cecilia; Farolfi, Alberto; Burgio, Salvatore Luca; Altavilla, Amelia; Martinelli, Giovanni; Giorgi, Ugo De

Year: 2020

Venue: Frontiers in Oncology

DOI: https://doi.org/10.3389/fonc.2020.565857

Paper Advancing CAR T-Cell Therapy for Solid Tumors: Lessons Learned from Lymphoma Treatment

Titov, Aleksei; Valiullina, Aygul; Zmievskaya, Ekaterina et al. · 2020 · Cancers · DOI

Full title: Advancing CAR T-Cell Therapy for Solid Tumors: Lessons Learned from Lymphoma Treatment

Authors: Titov, Aleksei; Valiullina, Aygul; Zmievskaya, Ekaterina; Zaikova, Ekaterina; Petukhov, Alexey; Miftakhova, Regina; Bulatov, Emil; Rizvanov, Albert A.

Year: 2020

Venue: Cancers

DOI: https://doi.org/10.3390/cancers12010125

Paper Advances in Cell and Immune Therapies for Melanoma

Timis, Tanase; Buruiana, Sanda; Dima, Delia et al. · 2025 · Biomedicines · DOI

Full title: Advances in Cell and Immune Therapies for Melanoma

Authors: Timis, Tanase; Buruiana, Sanda; Dima, Delia; Nistor, Mădălina; Mureșan, Ximena Maria; Cenariu, Diana; Țigu, Adrian Bogdan; Tomuleasa, Ciprian

Year: 2025

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines13010098

Paper Adoptive Cell Therapy—Harnessing Antigen-Specific T Cells to Target Solid Tumours

Chruściel, Elżbieta; Urban‐Wójciuk, Zuzanna; Arcimowicz, Łukasz et al. · 2020 · Cancers · DOI

Full title: Adoptive Cell Therapy—Harnessing Antigen-Specific T Cells to Target Solid Tumours

Authors: Chruściel, Elżbieta; Urban‐Wójciuk, Zuzanna; Arcimowicz, Łukasz; Kurkowiak, Małgorzata; Kowalski, Jacek; Gliwiński, Mateusz; Marjański, Tomasz; Rzyman, Witold; Biernat, Wojciech; Dziadziuszko, Rafał; Montesano, Carla; Bernardini, Roberta; Marek-Trzonkowska, Natalia

Year: 2020

Venue: Cancers

DOI: https://doi.org/10.3390/cancers12030683

Paper Strategies for Improving the Efficacy of CAR T Cells in Solid Cancers

Kyte, Jon Amund · 2022 · Cancers · DOI

Full title: Strategies for Improving the Efficacy of CAR T Cells in Solid Cancers

Authors: Kyte, Jon Amund

Year: 2022

Venue: Cancers

DOI: https://doi.org/10.3390/cancers14030571

Paper T Cell Engaging Immunotherapies, Highlighting Chimeric Antigen Receptor (CAR) T Cell Therapy

Bousser, Elien De; Callewaert, Nico; Festjens, Nele · 2021 · Cancers · DOI

Full title: T Cell Engaging Immunotherapies, Highlighting Chimeric Antigen Receptor (CAR) T Cell Therapy

Authors: Bousser, Elien De; Callewaert, Nico; Festjens, Nele

Year: 2021

Venue: Cancers

DOI: https://doi.org/10.3390/cancers13236067

Paper Chimeric Antigen Receptor Immunotherapy for Solid Tumors: Choosing the Right Ingredients for the Perfect Recipe

Castiello, Luciano; Santodonato, Laura; Napolitano, Mariarosaria et al. · 2022 · Cancers · DOI

Full title: Chimeric Antigen Receptor Immunotherapy for Solid Tumors: Choosing the Right Ingredients for the Perfect Recipe

Authors: Castiello, Luciano; Santodonato, Laura; Napolitano, Mariarosaria; Carlei, Davide; Montefiore, Enrica; Monque, Domenica M.; D’Agostino, Giuseppina; Aricò, Eleonora

Year: 2022

Venue: Cancers

DOI: https://doi.org/10.3390/cancers14215351

Paper Chimeric Antigen Receptor T-Cell Therapy in Metastatic Castrate-Resistant Prostate Cancer

Perera, Omattage Mahasha; Thomas, Patrick B.; Risbridger, Gail P. et al. · 2022 · Cancers · DOI

Full title: Chimeric Antigen Receptor T-Cell Therapy in Metastatic Castrate-Resistant Prostate Cancer

Authors: Perera, Omattage Mahasha; Thomas, Patrick B.; Risbridger, Gail P.; Taylor, Renea A.; Azad, Arun; Hofman, Michael S.; Williams, Elizabeth D.; Vela, Ian

Year: 2022

Venue: Cancers

DOI: https://doi.org/10.3390/cancers14030503

Paper Synthetic Notch-Receptor-Mediated Transmission of a Transient Signal into Permanent Information via CRISPR/Cas9-Based Genome Editing

Sgodda, Malte; Alfken, Susanne; Schambach, Axel et al. · 2020 · Cells · DOI

Full title: Synthetic Notch-Receptor-Mediated Transmission of a Transient Signal into Permanent Information via CRISPR/Cas9-Based Genome Editing

Authors: Sgodda, Malte; Alfken, Susanne; Schambach, Axel; Eggenschwiler, Reto; Fidzinski, Pawel; Hummel, Michael; Cantz, Tobias

Year: 2020

Venue: Cells

DOI: https://doi.org/10.3390/cells9091929

Paper State of the Art in CAR-T Cell Therapy for Solid Tumors: Is There a Sweeter Future?

Amorós-Pérez, Beatriz; Rivas-Pardo, Benigno; Moral, Manuel Gómez del et al. · 2024 · Cells · DOI

Full title: State of the Art in CAR-T Cell Therapy for Solid Tumors: Is There a Sweeter Future?

Authors: Amorós-Pérez, Beatriz; Rivas-Pardo, Benigno; Moral, Manuel Gómez del; Subiza, José Luis; Martı́nez-Naves, Eduardo

Year: 2024

Venue: Cells

DOI: https://doi.org/10.3390/cells13090725

Paper Modular Chimeric Antigen Receptor Systems for Universal CAR T Cell Retargeting

Sutherland, Ashley R.; Owens, Madeline N.; Geyer, C. Ronald · 2020 · International Journal of Molecular Sciences · DOI

Full title: Modular Chimeric Antigen Receptor Systems for Universal CAR T Cell Retargeting

Authors: Sutherland, Ashley R.; Owens, Madeline N.; Geyer, C. Ronald

Year: 2020

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms21197222

Paper When CAR Meets Stem Cells

Lee, Jung Min · 2019 · International Journal of Molecular Sciences · DOI

Full title: When CAR Meets Stem Cells

Authors: Lee, Jung Min

Year: 2019

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms20081825

Paper Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

Benmebarek, Mohamed-Reda; Karches, Clara H.; Cadilha, Bruno L. et al. · 2019 · International Journal of Molecular Sciences · DOI

Full title: Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

Authors: Benmebarek, Mohamed-Reda; Karches, Clara H.; Cadilha, Bruno L.; Lesch, Stefanie; Endres, Stefan; Kobold, Sebastian

Year: 2019

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms20061283

Paper Car T Cells in Solid Tumors: Overcoming Obstacles

Rojas, Joselyn; Díaz, María P.; Palmar, Jim et al. · 2024 · International Journal of Molecular Sciences · DOI

Full title: Car T Cells in Solid Tumors: Overcoming Obstacles

Authors: Rojas, Joselyn; Díaz, María P.; Palmar, Jim; Galán‐Freyle, Nataly J.; Morillo, Valery; Escalona, Daniel; González-Tórres, Henry J.; Torres, Wheeler; Quiroz, Elkin Navarro; Rivera-Porras, Diego; Bermúdez, Valmore

Year: 2024

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms25084170

Paper Decoding Strategies to Evade Immunoregulators Galectin-1, -3, and -9 and Their Ligands as Novel Therapeutics in Cancer Immunotherapy

Lau, Lee Seng; Mohammed, Norhan; Dimitroff, Charles J. · 2022 · International Journal of Molecular Sciences · DOI

Full title: Decoding Strategies to Evade Immunoregulators Galectin-1, -3, and -9 and Their Ligands as Novel Therapeutics in Cancer Immunotherapy

Authors: Lau, Lee Seng; Mohammed, Norhan; Dimitroff, Charles J.

Year: 2022

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms232415554

Paper Learning from TCR Signaling and Immunological Synapse Assembly to Build New Chimeric Antigen Receptors (CARs)

Cassioli, Chiara; Patrussi, Laura; Valitutti, Salvatore et al. · 2022 · International Journal of Molecular Sciences · DOI

Full title: Learning from TCR Signaling and Immunological Synapse Assembly to Build New Chimeric Antigen Receptors (CARs)

Authors: Cassioli, Chiara; Patrussi, Laura; Valitutti, Salvatore; Baldari, Cosima T.

Year: 2022

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms232214255

Paper Engineering Next-Generation CAR-T Cells for Better Toxicity Management

Alain E Andrea; Andrada S. Chiron; Stéphanie Bessoles et al. · 2020 · International Journal of Molecular Sciences · DOI

Full title: Engineering Next-Generation CAR-T Cells for Better Toxicity Management

Authors: Alain E Andrea; Andrada S. Chiron; Stéphanie Bessoles; S. Hacein-Bey-Abina

Year: 2020

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms21228620

Paper Cancer-Homing CAR-T Cells and Endogenous Immune Population Dynamics

Guerra, Emanuela; Pietro, Roberta Di; Basile, Mariangela et al. · 2021 · International Journal of Molecular Sciences · DOI

Full title: Cancer-Homing CAR-T Cells and Endogenous Immune Population Dynamics

Authors: Guerra, Emanuela; Pietro, Roberta Di; Basile, Mariangela; Trerotola, Marco; Alberti, Saverio

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms23010405

Paper CliniMACS Prodigy Manufacturing of Switchable, AND-Gate CAR T Cells

Alexandra von Jutrzenka-Trzebiatowski; R. Gupte; Cansu Daglar et al. · 2025 · International Journal of Molecular Sciences · DOI

Full title: CliniMACS Prodigy Manufacturing of Switchable, AND-Gate CAR T Cells

Authors: Alexandra von Jutrzenka-Trzebiatowski; R. Gupte; Cansu Daglar; N. Berndt; C. Arndt; Michael Bachmann; A. Feldmann

Year: 2025

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms26115024

Paper CAR-T-Cell-Based Cancer Immunotherapies: Potentials, Limitations, and Future Prospects

Choudhery, Mahmood S.; Arif, Taqdees; Mahmood, Ruhma et al. · 2024 · Journal of Clinical Medicine · DOI

Full title: CAR-T-Cell-Based Cancer Immunotherapies: Potentials, Limitations, and Future Prospects

Authors: Choudhery, Mahmood S.; Arif, Taqdees; Mahmood, Ruhma; Harris, David T.

Year: 2024

Venue: Journal of Clinical Medicine

DOI: https://doi.org/10.3390/jcm13113202

Paper The progress of CAR-T therapy in cancer and beyond

Huang, Yehong; Li, Lulu; Liu, Wenzhou et al. · 2020 · STEMedicine · DOI

Full title: The progress of CAR-T therapy in cancer and beyond

Authors: Huang, Yehong; Li, Lulu; Liu, Wenzhou; Tang, Tao; Chen, Liming

Year: 2020

Venue: STEMedicine

DOI: https://doi.org/10.37175/stemedicine.v1i3.47

Paper Faculty Opinions recommendation of T cell circuits that sense antigen density with an ultrasensitive threshold.

Thome, Margot · 2021 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · DOI

Full title: Faculty Opinions recommendation of T cell circuits that sense antigen density with an ultrasensitive threshold.

Authors: Thome, Margot

Year: 2021

Venue: Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI: https://doi.org/10.3410/f.739620747.793584303

Paper Migratory Engineering of T Cells for Cancer Therapy

Michaelides, Stefanos; Obeck, Hannah; Kechur, Daryna et al. · 2022 · Vaccines · DOI

Full title: Migratory Engineering of T Cells for Cancer Therapy

Authors: Michaelides, Stefanos; Obeck, Hannah; Kechur, Daryna; Endres, Stefan; Kobold, Sebastian

Year: 2022

Venue: Vaccines

DOI: https://doi.org/10.3390/vaccines10111845

Paper Chimeric Antigen Receptor T-Cell Therapy

Ogba, Ndiya; Arwood, Nicole M.; Bartlett, Nancy L. et al. · 2018 · Journal of the National Comprehensive Cancer Network · DOI

Full title: Chimeric Antigen Receptor T-Cell Therapy

Authors: Ogba, Ndiya; Arwood, Nicole M.; Bartlett, Nancy L.; Bloom, Mara G.; Brown, Patrick A.; Brown, Christine E.; Budde, Lihua E.; Carlson, Robert D.; Farnia, Stephanie; Fry, Terry J.; Garber, Morgan; Gardner, Rebecca; Gurschick, Lauren; Kropf, Patricia; Reitan, Jeff J.; Sauter, Craig S.; Shah, Bijal; Shpall, Elizabeth J.; Rosen, Steven T.

Year: 2018

Venue: Journal of the National Comprehensive Cancer Network

DOI: https://doi.org/10.6004/jnccn.2018.0073

Paper CAR T cell-induced systemic cytokine toxicity: current understanding and innovative designs

Yang, Zhaoqi · 2022 · Highlights in Science Engineering and Technology · DOI

Full title: CAR T cell-induced systemic cytokine toxicity: current understanding and innovative designs

Authors: Yang, Zhaoqi

Year: 2022

Venue: Highlights in Science Engineering and Technology

DOI: https://doi.org/10.54097/hset.v14i.1841

Paper Boolean Logic-Gated CAR T Cells with TCR Mimic Recognition Overcome Critical Antigen Targeting Barrier in Solid Tumors

Kyrysyuk, Oleksandr · 2020

Full title: Boolean Logic-Gated CAR T Cells with TCR Mimic Recognition Overcome Critical Antigen Targeting Barrier in Solid Tumors

Authors: Kyrysyuk, Oleksandr

Year: 2020

Paper Reprogramming T Cells to Interrogate Intracellular Disease Signatures

Ho, Patrick · 2019 · eScholarship (California Digital Library)

Full title: Reprogramming T Cells to Interrogate Intracellular Disease Signatures

Authors: Ho, Patrick

Year: 2019

Venue: eScholarship (California Digital Library)

Paper Engineering T cells with diverse mechanisms for improved tumor recognition precision

Jasper Z. Williams · 2019 · eScholarship (California Digital Library)

Full title: Engineering T cells with diverse mechanisms for improved tumor recognition precision

Authors: Jasper Z. Williams

Year: 2019

Venue: eScholarship (California Digital Library)

Paper Rewiring signaling responses to soluble extracellular cues for T-cell therapies and beyond

Chang, ZeNan · 2017 · eScholarship (California Digital Library)

Full title: Rewiring signaling responses to soluble extracellular cues for T-cell therapies and beyond

Authors: Chang, ZeNan

Year: 2017

Venue: eScholarship (California Digital Library)

Paper Tuning the SUPRA CAR to differentiate high/low Her2 levels

Shim, Inbo · 2022 · OpenBU (Boston University)

Full title: Tuning the SUPRA CAR to differentiate high/low Her2 levels

Authors: Shim, Inbo

Year: 2022

Venue: OpenBU (Boston University)

Paper Challenges and strategies of clinical application of CAR-T therapy in the treatment of tumors—a narrative review

Li, Weijing; Wu, Lili; Huang, Chen et al. · 2020 · Annals of Translational Medicine · DOI

Full title: Challenges and strategies of clinical application of CAR-T therapy in the treatment of tumors—a narrative review

Authors: Li, Weijing; Wu, Lili; Huang, Chen; Liu, Ruixia; Li, Zheng; Liu, Lihong; Shan, Baoen

Year: 2020

Venue: Annals of Translational Medicine

DOI: https://doi.org/10.21037/atm-20-4502

Paper Context-specific synthetic T cell promoters from assembled transcriptional elements

Wei, Jia; Mukherjee, Rithun; Ishida, T. et al. · 2023 · DOI

Full title: Context-specific synthetic T cell promoters from assembled transcriptional elements

Authors: Wei, Jia; Mukherjee, Rithun; Ishida, T.; Rosser, James M.; Saxby, Chris; Chase, John W.; Carlson, Marc; Sather, Cassie; Rahfeldt, Wolfgang A.; Meechan, Michael; Baldwin, Michael; Flint, Lindsay; Spurrell, Cailyn H.; Gustafson, Joshua A.; Johnson, Adam; Appelbaum, Jacob; Jensen, Michael C.

Year: 2023

DOI: https://doi.org/10.21203/rs.3.rs-3339290/v1

Paper Novel Adapter CAR-T cell Technology for precisely controllable Multiplex Cancer Targeting

Seitz, Christian; Mittelstaet, Joerg; Hau, Jana et al. · 2020 · DOI

Full title: Novel Adapter CAR-T cell Technology for precisely controllable Multiplex Cancer Targeting

Authors: Seitz, Christian; Mittelstaet, Joerg; Hau, Jana; Reiter, Selina; Illi, Clara; Kieble, Verena; Engert, Fabian; Drees, Britta; Bender, Giulia; Atar, Daniel; Krahl, Ann-Christin; Knopf, Philipp; Schroeder, Sarah M.; Paulsen, Nikolas; Rokhvarguer, Alexander; Scheuermann, Sophia; Rapp, Elena; Mast, Anna‐Sophia; Rabsteyn, Armin; Schleicher, Sabine; Grote, Stefan; Schilbach, Karin; Kneilling, Manfred; Pichler, Bernd J.; Lock, Dominik; Kotter, Bettina; Dapa, Sandra; Miltenyi, Stefan; Kaiser, Andrew; Lang, Peter; Handgretinger, Rupert; Schlegel, Patrick

Year: 2020

DOI: https://doi.org/10.21203/rs.3.rs-96150/v1

Paper The Landscape of Receptor-Mediated Precision Cancer Combination Therapy: A Single-Cell Perspective

Ahmadi, Saba; Sukprasert, Pattara; Vegesna, Rahulsimham et al. · 2020 · DOI

Full title: The Landscape of Receptor-Mediated Precision Cancer Combination Therapy: A Single-Cell Perspective

Authors: Ahmadi, Saba; Sukprasert, Pattara; Vegesna, Rahulsimham; Sinha, Sanju; Schischlik, Fiorella; Artzi, Natalie; Khuller, Samir; Schäffer, Alejandro A.; Ruppin, Eytan

Year: 2020

DOI: https://doi.org/10.1101/2020.01.28.923532

Paper Prospects to Improve Chimeric Antigen Receptor T-Cell Therapy for Solid Tumors

Jin, Chuan; Yu, Di; Essand, Magnus · 2016 · Immunotherapy · DOI

Full title: Prospects to Improve Chimeric Antigen Receptor T-Cell Therapy for Solid Tumors

Authors: Jin, Chuan; Yu, Di; Essand, Magnus

Year: 2016

Venue: Immunotherapy

DOI: https://doi.org/10.2217/imt-2016-0125

Paper PRECLINICAL MOUSE MODELS IN ADOPTIVE CELL THERAPIES OF CANCER

Rajčević, Uroš; Smole, Anže · 2022 · Slovenian Veterinary Research · DOI

Full title: PRECLINICAL MOUSE MODELS IN ADOPTIVE CELL THERAPIES OF CANCER

Authors: Rajčević, Uroš; Smole, Anže

Year: 2022

Venue: Slovenian Veterinary Research

DOI: https://doi.org/10.26873/svr-1513-2022

Paper Chimeric Antigen Receptor (CAR) T-cell Treatment in Renal Cell Carcinoma: Current Clinical Trials and Future Directions

Lyou, Yung; Dorff, Tanya B. · 2022 · Kidney Cancer · DOI

Full title: Chimeric Antigen Receptor (CAR) T-cell Treatment in Renal Cell Carcinoma: Current Clinical Trials and Future Directions

Authors: Lyou, Yung; Dorff, Tanya B.

Year: 2022

Venue: Kidney Cancer

DOI: https://doi.org/10.3233/kca-220001

Paper Solid tumours: Building bridges to CAR‐T success

Maher, John · 2023 · Clinical and Translational Discovery · DOI

Full title: Solid tumours: Building bridges to CAR‐T success

Authors: Maher, John

Year: 2023

Venue: Clinical and Translational Discovery

DOI: https://doi.org/10.1002/ctd2.179

Paper Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology

Watanabe, Keisuke; Kuramitsu, Shunichiro; Posey, Avery D. et al. · 2018 · Frontiers in Immunology · DOI

Full title: Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology

Authors: Watanabe, Keisuke; Kuramitsu, Shunichiro; Posey, Avery D.; June, Carl H.

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.02486

Paper JAK/STAT-Dependent Chimeric Antigen Receptor (CAR) Expression: A Design Benefiting From a Dual AND/OR Gate Aiming to Increase Specificity, Reduce Tumor Escape and Affect Tumor Microenvironment

Khanali, Javad; Azangou‐Khyavy, Mohammadreza; Boroomand-Saboor, Melika et al. · 2021 · Frontiers in Immunology · DOI

Full title: JAK/STAT-Dependent Chimeric Antigen Receptor (CAR) Expression: A Design Benefiting From a Dual AND/OR Gate Aiming to Increase Specificity, Reduce Tumor Escape and Affect Tumor Microenvironment

Authors: Khanali, Javad; Azangou‐Khyavy, Mohammadreza; Boroomand-Saboor, Melika; Ghasemi, Mobina; Niknejad, Hassan

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.638639

Paper Engineered CAR-Macrophages as Adoptive Immunotherapies for Solid Tumors

Sloas, Christopher; Gill, Saar; Klichinsky, Michael · 2021 · Frontiers in Immunology · DOI

Full title: Engineered CAR-Macrophages as Adoptive Immunotherapies for Solid Tumors

Authors: Sloas, Christopher; Gill, Saar; Klichinsky, Michael

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.783305

Paper Implementing Logic Gates for Safer Immunotherapy of Cancer

Savanur, Mohammed Azharuddin; Weinstein-Marom, Hadas; Gross, Gideon · 2021 · Frontiers in Immunology · DOI

Full title: Implementing Logic Gates for Safer Immunotherapy of Cancer

Authors: Savanur, Mohammed Azharuddin; Weinstein-Marom, Hadas; Gross, Gideon

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.780399

Paper Targeting immune checkpoints: how to use natural killer cells for fighting against solid tumors

Ghaedrahmati, Farhoodeh; Esmaeil, Nafiseh; Abbaspour, Maryam · 2022 · Cancer Communications · DOI

Full title: Targeting immune checkpoints: how to use natural killer cells for fighting against solid tumors

Authors: Ghaedrahmati, Farhoodeh; Esmaeil, Nafiseh; Abbaspour, Maryam

Year: 2022

Venue: Cancer Communications

DOI: https://doi.org/10.1002/cac2.12394

Paper Synthetic biology, genetic circuits and machine learning: a new age of cancer therapy

Prasad, Krishneel; Cross, Ryan; Jenkins, Misty R. · 2023 · Molecular Oncology · DOI

Full title: Synthetic biology, genetic circuits and machine learning: a new age of cancer therapy

Authors: Prasad, Krishneel; Cross, Ryan; Jenkins, Misty R.

Year: 2023

Venue: Molecular Oncology

DOI: https://doi.org/10.1002/1878-0261.13420

Paper Switching on the green light for chimeric antigen receptor T‐cell therapy

Mardiana, Sherly; Lai, Junyun; House, Imran G. et al. · 2019 · Clinical & Translational Immunology · DOI

Full title: Switching on the green light for chimeric antigen receptor T‐cell therapy

Authors: Mardiana, Sherly; Lai, Junyun; House, Imran G.; Beavis, Paul A.; Darcy, Phillip K.

Year: 2019

Venue: Clinical & Translational Immunology

DOI: https://doi.org/10.1002/cti2.1046

Paper Light‐Controllable Binary Switch Activation of CAR T Cells

Kobayashi, Aya; Nobili, Alberto; Neier, Steven C. et al. · 2022 · ChemMedChem · DOI

Full title: Light‐Controllable Binary Switch Activation of CAR T Cells

Authors: Kobayashi, Aya; Nobili, Alberto; Neier, Steven C.; Sadiki, Amissi; Distel, R; Zhou, Zhaohui Sunny; Novina, Carl D.

Year: 2022

Venue: ChemMedChem

DOI: https://doi.org/10.1002/cmdc.202100722

Paper Boolean logic in synthetic biology and biomaterials: Towards living materials in mammalian cell therapeutics

Eric M Bressler; Sarah Adams; Rong Liu et al. · 2023 · Clinical and Translational Medicine · DOI

Full title: Boolean logic in synthetic biology and biomaterials: Towards living materials in mammalian cell therapeutics

Authors: Eric M Bressler; Sarah Adams; Rong Liu; Y. Colson; W. Wong; M. Grinstaff

Year: 2023

Venue: Clinical and Translational Medicine

DOI: https://doi.org/10.1002/ctm2.1244

Paper CAR‐T‐cell products in solid tumors: Progress, challenges, and strategies

Qian, Kewen; Li, Guangyao; Zhang, Shuyi et al. · 2024 · Interdisciplinary medicine · DOI

Full title: CAR‐T‐cell products in solid tumors: Progress, challenges, and strategies

Authors: Qian, Kewen; Li, Guangyao; Zhang, Shuyi; Fu, Wenyan; Li, Tian; Zhao, Jian; Lei, Changhai; Wang, Yuqing; Hu, Shi

Year: 2024

Venue: Interdisciplinary medicine

DOI: https://doi.org/10.1002/inmd.20230047

Paper Advanced strategies in improving the immunotherapeutic effect of CAR‐T cell therapy

Wang, Minmin; Jia, Linzi; Dai, Xiangpeng et al. · 2024 · Molecular Oncology · DOI

Full title: Advanced strategies in improving the immunotherapeutic effect of CAR‐T cell therapy

Authors: Wang, Minmin; Jia, Linzi; Dai, Xiangpeng; Zhang, Xiaoling

Year: 2024

Venue: Molecular Oncology

DOI: https://doi.org/10.1002/1878-0261.13621

Paper The antigen‐binding moiety in the driver's seat of CARs

Hanssens, Heleen; Meeus, Fien; Veirman, Kim De et al. · 2021 · Medicinal Research Reviews · DOI

Full title: The antigen‐binding moiety in the driver's seat of CARs

Authors: Hanssens, Heleen; Meeus, Fien; Veirman, Kim De; Breckpot, Karine; Devoogdt, Nick

Year: 2021

Venue: Medicinal Research Reviews

DOI: https://doi.org/10.1002/med.21818

Paper Chimeric antigen receptor transduced T cells: Tuning up for the next generation

Schubert, Maria‐Luisa; Hoffmann, Jean‐Marc; Dreger, Peter et al. · 2017 · International Journal of Cancer · DOI

Full title: Chimeric antigen receptor transduced T cells: Tuning up for the next generation

Authors: Schubert, Maria‐Luisa; Hoffmann, Jean‐Marc; Dreger, Peter; Müller‐Tidow, Carsten; Schmitt, Michael

Year: 2017

Venue: International Journal of Cancer

DOI: https://doi.org/10.1002/ijc.31147

Paper CAR-modified immune cells as a rapidly evolving approach in the context of cancer immunotherapies

Faeq, Mohammed Hikmat; Al‐Haideri, Maysoon; Mohammad, Talar Ahmad Merza et al. · 2023 · Medical Oncology · DOI

Full title: CAR-modified immune cells as a rapidly evolving approach in the context of cancer immunotherapies

Authors: Faeq, Mohammed Hikmat; Al‐Haideri, Maysoon; Mohammad, Talar Ahmad Merza; Gharebakhshi, Farshad; Marofi, Faroogh; Tahmasebi, Safa; Modaresahmadi, Shadan

Year: 2023

Venue: Medical Oncology

DOI: https://doi.org/10.1007/s12032-023-02019-4

Paper Therapeutic cell engineering: designing programmable synthetic genetic circuits in mammalian cells

Mansouri, Maysam; Fussenegger, Martin · 2021 · Protein & Cell · DOI

Full title: Therapeutic cell engineering: designing programmable synthetic genetic circuits in mammalian cells

Authors: Mansouri, Maysam; Fussenegger, Martin

Year: 2021

Venue: Protein & Cell

DOI: https://doi.org/10.1007/s13238-021-00876-1

Paper Current status and perspectives of chimeric antigen receptor modified T cells for cancer treatment

Wang, Zhenguang; Guo, Yelei; Han, Weidong · 2017 · Protein & Cell · DOI

Full title: Current status and perspectives of chimeric antigen receptor modified T cells for cancer treatment

Authors: Wang, Zhenguang; Guo, Yelei; Han, Weidong

Year: 2017

Venue: Protein & Cell

DOI: https://doi.org/10.1007/s13238-017-0400-z

Paper Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits

Roybal, Kole T.; Rupp, Levi J.; Morsut, Leonardo et al. · 2016 · Cell · DOI

Full title: Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits

Authors: Roybal, Kole T.; Rupp, Levi J.; Morsut, Leonardo; Walker, Whitney J.; McNally, Krista A.; Park, Jason S.; Lim, Wendell A.

Year: 2016

Venue: Cell

DOI: https://doi.org/10.1016/j.cell.2016.01.011

Paper From antibodies to living drugs: Quo vadis cancer immunotherapy?

Szöőr, Árpád; Szöllõsi, János; Vereb, György · 2021 · Biologia Futura · DOI

Full title: From antibodies to living drugs: Quo vadis cancer immunotherapy?

Authors: Szöőr, Árpád; Szöllõsi, János; Vereb, György

Year: 2021

Venue: Biologia Futura

DOI: https://doi.org/10.1007/s42977-021-00072-6

Paper CAR-T design: Elements and their synergistic function

Jayaraman, Jayapriya; Mellody, Michael; Hou, Andrew J. et al. · 2020 · EBioMedicine · DOI

Full title: CAR-T design: Elements and their synergistic function

Authors: Jayaraman, Jayapriya; Mellody, Michael; Hou, Andrew J.; Desai, Ruchi P.; Fung, Audrey; Pham, An Huynh Thuy; Chen, Yvonne Y.; Zhao, Weian

Year: 2020

Venue: EBioMedicine

DOI: https://doi.org/10.1016/j.ebiom.2020.102931

Paper Targeting of low ALK antigen density neuroblastoma using AND logic-gate engineered CAR-T cells

Halliwell, Emma; Vitali, Alice; Muller, Henrike et al. · 2022 · Cytotherapy · DOI

Full title: Targeting of low ALK antigen density neuroblastoma using AND logic-gate engineered CAR-T cells

Authors: Halliwell, Emma; Vitali, Alice; Muller, Henrike; Alonso-Ferrero, Maria; Barisa, Marta; Gavriil, Artemis; Piapi, Alice; Leboreiro-Babe, Clara; Gileadi, Talia; Yeung, Jenny; Pataillot-Meakin, Thomas; Fisher, Jonathan; Tucker, Lizzie; Donovan, Laura; Chesler, Louis; Chester, Kerry; Anderson, John

Year: 2022

Venue: Cytotherapy

DOI: https://doi.org/10.1016/j.jcyt.2022.10.007

Paper Co-expression patterns of chimeric antigen receptor (CAR)-T cell target antigens in primary and recurrent ovarian cancer.

Allyson C. Banville; M. Wouters; A. Oberg et al. · 2020 · Gynecologic Oncology · DOI

Full title: Co-expression patterns of chimeric antigen receptor (CAR)-T cell target antigens in primary and recurrent ovarian cancer.

Authors: Allyson C. Banville; M. Wouters; A. Oberg; Krista M. Goergen; M. Maurer; K. Milne; J. Ashkani; E. Field; Chanel Ghesquiere; Steven J. M. Jones; M. Block; B. Nelson

Year: 2020

Venue: Gynecologic Oncology

DOI: https://doi.org/10.1016/j.ygyno.2020.12.005

Paper Engineering transcriptional regulation for cell-based therapies

Recktenwald, Matthias; Hutt, Evan; Davis, Leah et al. · 2024 · SLAS TECHNOLOGY · DOI

Full title: Engineering transcriptional regulation for cell-based therapies

Authors: Recktenwald, Matthias; Hutt, Evan; Davis, Leah; MacAulay, James; Daringer, Nichole M.; Galie, Peter A.; Staehle, Mary; Vega, Sebastián L.

Year: 2024

Venue: SLAS TECHNOLOGY

DOI: https://doi.org/10.1016/j.slast.2024.100121

Paper CAR T‐cell therapy of solid tumors

Yong, Carmen S.; Dardalhon, Valérie; Devaud, Christel et al. · 2016 · Immunology and Cell Biology · DOI

Full title: CAR T‐cell therapy of solid tumors

Authors: Yong, Carmen S.; Dardalhon, Valérie; Devaud, Christel; Taylor, Naomi; Darcy, Phillip K.; Kershaw, Michael H.

Year: 2016

Venue: Immunology and Cell Biology

DOI: https://doi.org/10.1038/icb.2016.128

Paper Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells

Christopher C. Kloss; M. Condomines; M. Cartellieri et al. · 2012 · Nature Biotechnology · DOI

Full title: Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells

Authors: Christopher C. Kloss; M. Condomines; M. Cartellieri; M. Bachmann; M. Sadelain

Year: 2012

Venue: Nature Biotechnology

DOI: https://doi.org/10.1038/nbt.2459

Thesis Targeting of Aberrant alpha v beta 6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells

Whilding, LM; Parente-Pereira, AC; Zabinski, T et al. · 2017 · Imperial College London · DOI

Full title: Targeting of Aberrant alpha v beta 6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells

Authors: Whilding, LM; Parente-Pereira, AC; Zabinski, T; Davies, DM; Petrovic, RMG; Kao, YV; Saxena, SA; Romain, A; Costa-Guerra, JA; Violette, S; Itamochi, H; Ghaem-Maghami, S; Vallath, S; Marshall, JF; Maher, J

Year: 2017

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000391901600025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Autologous CAR T-cell therapies supply chain: challenges and opportunities?

Papathanasiou, Maria M; Stamatis, Christos; Lakelin, Matthew et al. · 2020 · Imperial College London · DOI

Full title: Autologous CAR T-cell therapies supply chain: challenges and opportunities?

Authors: Papathanasiou, Maria M; Stamatis, Christos; Lakelin, Matthew; Farid, Suzanne; Titchener-Hooker, Nigel; Shah, Nilay

Year: 2020

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000508143300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis A Novel Fully-Human Potency-Matched Dual Cytokine-Antibody Fusion Protein Targets Carbonic Anhydrase IX in Renal Cell Carcinomas

De Luca, Roberto; Gouyou, Baptiste; Ongaro, Tiziano et al. · 2019 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: A Novel Fully-Human Potency-Matched Dual Cytokine-Antibody Fusion Protein Targets Carbonic Anhydrase IX in Renal Cell Carcinomas

Authors: De Luca, Roberto; Gouyou, Baptiste; Ongaro, Tiziano; Villa, Alessandra; Ziffels, Barbara; Sannino, Alessandro; Buttinoni, Gianluca; Galeazzi, Simone; Mazzacuva, Mirko; Neri, Dario; id_orcid0000-0001-5234-7370

Year: 2019

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/385661

Thesis Engineering Cell-Based Systems for Smart Cancer Therapy

Mirkhani, Nima; Gwisai, Tinotenda; Schuerle, Simone · 2022 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Engineering Cell-Based Systems for Smart Cancer Therapy

Authors: Mirkhani, Nima; Gwisai, Tinotenda; Schuerle, Simone

Year: 2022

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/508222

Thesis An Immune Atlas of Clear Cell Renal Cell Carcinoma

Chevrier, Stéphane; Levine, Jacob Harrison; Zanotelli, Vito Riccardo Tomaso et al. · 2017 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: An Immune Atlas of Clear Cell Renal Cell Carcinoma

Authors: Chevrier, Stéphane; Levine, Jacob Harrison; Zanotelli, Vito Riccardo Tomaso; Silina, Karina; Schulz, Daniel; Bacac, Marina; Ries, Carola Hermine; Ailles, Laurie; Jewett, Michael Alexander Spencer; Moch, Holger; van den Broek, Maries; Beisel, Christian; Stadler, Michael Beda; Gedye, Craig; Reis, Bernhard; Pe'er, Dana; Bodenmiller, Bernd

Year: 2017

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/191799

Thesis A Functional Screening Strategy for Engineering Chimeric Antigen Receptors with Reduced On-Target, Off-Tumor Activation

Di Roberto, Raphaël B.; Castellanos-Rueda, Rocío; Frey, Samara et al. · 2020 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: A Functional Screening Strategy for Engineering Chimeric Antigen Receptors with Reduced On-Target, Off-Tumor Activation

Authors: Di Roberto, Raphaël B.; Castellanos-Rueda, Rocío; Frey, Samara; Egli, David; Vazquez-Lombardi, Rodrigo; Kapetanovic, Edo; Kucharczyk, Jakub; Reddy, Sai T.

Year: 2020

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/454511

Thesis Enhancing cell-based therapies with synthetic gene circuits responsive to molecular stimuli

Galvan, Silvia; Teixeira, Ana P.; Fussenegger, Martin et al. · 2024 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Enhancing cell-based therapies with synthetic gene circuits responsive to molecular stimuli

Authors: Galvan, Silvia; Teixeira, Ana P.; Fussenegger, Martin; id_orcid0000-0001-8545-667X

Year: 2024

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/679539

Thesis Discovery and validation of human genomic safe harbor sites for gene and cell therapies

Aznauryan, Erik; id_orcid0000-0001-7666-7299; Yermanos, Alexander et al. · 2022 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Discovery and validation of human genomic safe harbor sites for gene and cell therapies

Authors: Aznauryan, Erik; id_orcid0000-0001-7666-7299; Yermanos, Alexander; Kinzina, Elvira; Devaux, Anna; Kapetanovic, Edo; Milanova, Denitsa; Church, George M.; Reddy, Sai T.

Year: 2022

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/531716

Thesis Synthetic Gene Circuits for Regulation of Next-Generation Cell-Based Therapeutics

Teixeira, Ana P.; Fussenegger, Martin; id_orcid0000-0001-8545-667X · 2024 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Synthetic Gene Circuits for Regulation of Next-Generation Cell-Based Therapeutics

Authors: Teixeira, Ana P.; Fussenegger, Martin; id_orcid0000-0001-8545-667X

Year: 2024

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/650641

Thesis Engineering next-generation chimeric antigen receptor-T cells: recent breakthroughs and remaining challenges in design and screening of novel chimeric antigen receptor variants

Mei, Anna; id_orcid0000-0001-7091-4471; Letscher, Kevin P. et al. · 2024 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Engineering next-generation chimeric antigen receptor-T cells: recent breakthroughs and remaining challenges in design and screening of novel chimeric antigen receptor variants

Authors: Mei, Anna; id_orcid0000-0001-7091-4471; Letscher, Kevin P.; Reddy, Sai

Year: 2024

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/704470

Thesis Engineering p95HER2 CAR T cells as an effective immunotherapy for HER2-positive tumors

Grinyó i Escuer, Ariadna · 2025 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Engineering p95HER2 CAR T cells as an effective immunotherapy for HER2-positive tumors

Authors: Grinyó i Escuer, Ariadna

Year: 2025

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/694644

Thesis Modeling single-cell data for cancer immunotherapy: Never underestimate the power of one

Driessen, Alice · 2025 · ETH Zurich Research Collection · DOI

Full title: Modeling single-cell data for cancer immunotherapy: Never underestimate the power of one

Authors: Driessen, Alice

Year: 2025

Venue: ETH Zurich Research Collection

DOI: http://hdl.handle.net/20.500.11850/739399

Thesis Modulation of T Cells to Promote an Anti-Tumor Response: Activation And Inhibition Of T Cells For Efficacy In T-Cell Lymphomas And Melanoma

Kerr, Samuel Robert · 2022 · Yale University · DOI

Full title: Modulation of T Cells to Promote an Anti-Tumor Response: Activation And Inhibition Of T Cells For Efficacy In T-Cell Lymphomas And Melanoma

Authors: Kerr, Samuel Robert

Year: 2022

Venue: Yale University

DOI: https://elischolar.library.yale.edu/gsas_dissertations/613

Thesis GENETIC ENGINEERING STRATEGIES FOR EXPANDING THE THERAPEUTIC INDEX OF CHIMERIC ANTIGEN RECEPTOR CELLULAR IMMUNOTHERAPIES

Benton, Alexander · 2025 · University of Pennsylvania · DOI

Full title: GENETIC ENGINEERING STRATEGIES FOR EXPANDING THE THERAPEUTIC INDEX OF CHIMERIC ANTIGEN RECEPTOR CELLULAR IMMUNOTHERAPIES

Authors: Benton, Alexander

Year: 2025

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/60809

Thesis Development of two novel chimeric antigen receptor platforms to advance the control and specificity of next-generation T cell therapies

Shaw, Lauren, Candice · 2024 · University of Pennsylvania · DOI

Full title: Development of two novel chimeric antigen receptor platforms to advance the control and specificity of next-generation T cell therapies

Authors: Shaw, Lauren, Candice

Year: 2024

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/59714

Thesis Harnessing Regnase-1 and Roquin-1 activity to modulate T cell function

Mai, David · 2024 · University of Pennsylvania · DOI

Full title: Harnessing Regnase-1 and Roquin-1 activity to modulate T cell function

Authors: Mai, David

Year: 2024

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/60177

Thesis T cell receptor redirected T cells in tumour immunotherapy

Gao, F · 2024 · University of Oxford - ORA · DOI

Full title: T cell receptor redirected T cells in tumour immunotherapy

Authors: Gao, F

Year: 2024

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:1c18c408-ff35-435a-8b9a-a6fc81a669e6

Thesis Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function

Barden, Markus; Elsenbroich, Patrick Ronan; Haas, Vivian et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function

Authors: Barden, Markus; Elsenbroich, Patrick Ronan; Haas, Vivian; Ertelt, Moritz; Pervan, Philip; Velas, Lukas; Gergely, Bence; Szöőr, Árpád; Harrer, Dennis Christoph; Bezler, Valerie; Holzinger, Astrid; Friis, Rasmus Ulslev Wegener; Vereb, Gyorgy; Schütz, Gerhard J.; Schoeder, Clara T.; Hombach, Andreas A.; Abken, Hinrich

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/175bbcd8-2697-424a-b5f4-a511b34fd83c

Thesis Analyzing functional heterogeneity of effector cells for enhanced adoptive cell therapy applications

Kiel Rasmussen, AC C.; Hulen, T. M.; Petersen, D. L. et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Analyzing functional heterogeneity of effector cells for enhanced adoptive cell therapy applications

Authors: Kiel Rasmussen, AC C.; Hulen, T. M.; Petersen, D. L.; Jacobsen, M. J.; Mikkelsen, M. J.; Met, Özcan; id_orcid 0000-0002-3256-7592; Donia, M.; Chamberlain, C. A.; Mouritzen, P.

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/77668dcd-f455-4fd5-9743-9f689e740b65

Thesis Factors affecting the commercialization of cellular based therapeutics

Pettitt, D · 2018 · University of Oxford - ORA · DOI

Full title: Factors affecting the commercialization of cellular based therapeutics

Authors: Pettitt, D

Year: 2018

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:706415ea-dbea-4c3d-b3f6-4590621f33c5

Thesis T-cell Responses in the Microenvironment of Primary Renal Cell Carcinoma-Implications for Adoptive Cell Therapy

Andersen, Rikke; Westergaard, Marie Christine Wulff; Kjeldsen, Julie Westerlin et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: T-cell Responses in the Microenvironment of Primary Renal Cell Carcinoma-Implications for Adoptive Cell Therapy

Authors: Andersen, Rikke; Westergaard, Marie Christine Wulff; Kjeldsen, Julie Westerlin; Mueller, Anja; Pedersen, Natasja Wulff; Hadrup, Sine Reker; id_orcid 0000-0002-5937-4344; Met, Ozcan; Seliger, Barbara; Kromann-Andersen, Bjarne; Hasselager, Thomas; Donia, Marco; Svane, Inge Marie

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/dc9ad723-bc94-4d74-8138-bc3dbace0441

Thesis Computationally dissecting autologous and therapy-induced immune responses at tissue and single cell level

Moranzoni, Giorgia · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Computationally dissecting autologous and therapy-induced immune responses at tissue and single cell level

Authors: Moranzoni, Giorgia

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/eac0cccc-9434-4d11-b426-9c319cba565e

Thesis Analyzing functional heterogeneity of effector cells for enhanced adoptive cell therapy applications

Kiel Rasmussen, AC C.; Hulen, T. M.; Petersen, D. L. et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Analyzing functional heterogeneity of effector cells for enhanced adoptive cell therapy applications

Authors: Kiel Rasmussen, AC C.; Hulen, T. M.; Petersen, D. L.; Jacobsen, M. J.; Mikkelsen, M. J.; Met, Özcan; id_orcid 0000-0002-3256-7592; Donia, M.; Chamberlain, C. A.; Mouritzen, P.

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/77668dcd-f455-4fd5-9743-9f689e740b65

Thesis Progressive immune dysfunction with advancing disease stage in renal cell carcinoma

Braun, David A; Street, Kelly; Burke, Kelly P. et al. · 2021 · Technical University of Denmark (DTU) · DOI

Full title: Progressive immune dysfunction with advancing disease stage in renal cell carcinoma

Authors: Braun, David A; Street, Kelly; Burke, Kelly P.; Cookmeyer, David L.; Denize, Thomas; Pedersen, Christina B.; id_orcid 0000-0002-9895-0930; Gohil, Satyen H.; Schindler, Nicholas; Pomerance, Lucas; Hirsch, Laure; Bakouny, Ziad; Hou, Yue; Forman, Juliet; Huang, Teddy; Li, Shuqiang; Cui, Ang; Keskin, Derin B.; Steinharter, John; Bouchard, Gabrielle; Sun, Maxine; Pimenta, Erica M.; Xu, Wenxin; Mahoney, Kathleen M.; McGregor, Bradley A.; Hirsch, Michelle S.; Chang, Steven L.; Livak, Kenneth J.; McDermott, David F.; Shukla, Sachet A.; Olsen, Lars R.; id_orcid 0000-0002-6725-7850; Signoretti, Sabina; Sharpe, Arlene H.; Irizarry, Rafael A.; Choueiri, Toni K.; Wu, Catherine J.

Year: 2021

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/04f73ef8-6639-4998-8916-d0c74486dfc3

Thesis Augmenting engineered T-cell strategies in solid cancers through epigenetic priming

Nielsen, Aaraby Y.; Ormhøj, Maria; Traynor, Sofie et al. · 2020 · Technical University of Denmark (DTU) · DOI

Full title: Augmenting engineered T-cell strategies in solid cancers through epigenetic priming

Authors: Nielsen, Aaraby Y.; Ormhøj, Maria; Traynor, Sofie; Gjerstorff, Morten F.

Year: 2020

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/57e9d7b8-a5e3-45eb-9fe0-de483629beeb

Thesis Novel technologies for tracking and engineering of CAR T cells

Friis, Rasmus Ulslev Wegener · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Novel technologies for tracking and engineering of CAR T cells

Authors: Friis, Rasmus Ulslev Wegener

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/28177a51-a23b-4693-8828-9d39319304a6

Thesis Developing synthetic yeast-based cell-cell communication tools for immune cell activation and manipulation

Deichmann, Marcus · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Developing synthetic yeast-based cell-cell communication tools for immune cell activation and manipulation

Authors: Deichmann, Marcus

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/700da2fc-d334-4e20-b444-bccf85598922

Thesis T-cell Responses in the Microenvironment of Primary Renal Cell Carcinoma-Implications for Adoptive Cell Therapy

Andersen, Rikke; Westergaard, Marie Christine Wulff; Kjeldsen, Julie Westerlin et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: T-cell Responses in the Microenvironment of Primary Renal Cell Carcinoma-Implications for Adoptive Cell Therapy

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/dc9ad723-bc94-4d74-8138-bc3dbace0441

Thesis Computationally dissecting autologous and therapy-induced immune responses at tissue and single cell level

Moranzoni, Giorgia · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Computationally dissecting autologous and therapy-induced immune responses at tissue and single cell level

Authors: Moranzoni, Giorgia

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/eac0cccc-9434-4d11-b426-9c319cba565e

Thesis Tumour-infiltrating lymphocyte therapy comes of age in the era of genetic engineering

Crowther, Michael D.; Sohlin, Joel E.; Svane, Inge Marie et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Tumour-infiltrating lymphocyte therapy comes of age in the era of genetic engineering

Authors: Crowther, Michael D.; Sohlin, Joel E.; Svane, Inge Marie; Met, Özcan; id_orcid 0000-0002-3256-7592

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/febc3b9f-8a1b-4543-a5f8-da9d8f710651

Thesis Development Of Optically Responsive Cytokine Cancer Immunotherapies

Birnbaum, Lacey Anne · 2024 · Georgia Institute of Technology · DOI

Full title: Development Of Optically Responsive Cytokine Cancer Immunotherapies

Authors: Birnbaum, Lacey Anne

Year: 2024

Venue: Georgia Institute of Technology

DOI: https://hdl.handle.net/1853/73004

Thesis Engineering Metabolically Weaponized T Cell Therapies for Solid Tumor Translation

Blazeck, John; Cox, John · 2024 · Georgia Institute of Technology · DOI

Full title: Engineering Metabolically Weaponized T Cell Therapies for Solid Tumor Translation

Authors: Blazeck, John; Cox, John

Year: 2024

Venue: Georgia Institute of Technology

DOI: https://hdl.handle.net/1853/75450

Thesis Synthetic Cells and Molecules in Cellular Immunotherapy

Lin, Haikun; Li, Chentao; Zhang, Wanying et al. · 2024 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Synthetic Cells and Molecules in Cellular Immunotherapy

Authors: Lin, Haikun; Li, Chentao; Zhang, Wanying; Wu, Boxiang; Wang, Yanan; Wang, Shimin; Wang, Dongrui; Li, Xia; Huang, He

Year: 2024

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-140009

Thesis Engineering CAR-T Therapeutics for Enhanced Solid Tumor Targeting

Zhu, Bonnie Danqing; Kim, Won Joon; Lee, Hyunjin et al. · 2025 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Engineering CAR-T Therapeutics for Enhanced Solid Tumor Targeting

Authors: Zhu, Bonnie Danqing; Kim, Won Joon; Lee, Hyunjin; Bao, Xiaoping; Kim, Pilnam

Year: 2025

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-145183

Thesis An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammatory CAR macrophages in renal cell carcinoma

Jing, Weiqiang; Zhu, Bonnie Danqing; Shi, Benkang et al. · 2025 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammatory CAR macrophages in renal cell carcinoma

Authors: Jing, Weiqiang; Zhu, Bonnie Danqing; Shi, Benkang; Jiang, Xinyi

Year: 2025

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-148731

Thesis Optimising the Efficacy and Safety of Anti-Mesothelin Chimeric Antigen Receptor T-cell Therapy in Cancer

Chu, Gerard Joseph Kuo-Gee Latt · 2023 · University of Sydney · DOI

Full title: Optimising the Efficacy and Safety of Anti-Mesothelin Chimeric Antigen Receptor T-cell Therapy in Cancer

Authors: Chu, Gerard Joseph Kuo-Gee Latt

Year: 2023

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/30105

Thesis Uncertainty quantification for gene delivery methods: a roadmap for pDNA manufacturing from phase I clinical trials to commercialization

Triantafyllou, Niki; Sarkis, Miriam; Krassakopoulou, Aikaterina et al. · 2024 · Imperial College London · DOI

Full title: Uncertainty quantification for gene delivery methods: a roadmap for pDNA manufacturing from phase I clinical trials to commercialization

Authors: Triantafyllou, Niki; Sarkis, Miriam; Krassakopoulou, Aikaterina; Shah, Nilay; Papathanasiou, Maria M; Kontoravdi, Cleo

Year: 2024

Venue: Imperial College London

DOI: http://dx.doi.org/10.1002/biot.202300103

Thesis Smart CAR-T Nanosymbionts: archetypes and proto-models

Baena, Juan C; Victoria, Juan Sebastián; Toro-Pedroza, Alejandro et al. · 2025 · Imperial College London · DOI

Full title: Smart CAR-T Nanosymbionts: archetypes and proto-models

Authors: Baena, Juan C; Victoria, Juan Sebastián; Toro-Pedroza, Alejandro; Aragón, Cristian C; Ortiz-Guzman, Joshua; Garcia-Robledo, Juan Esteban; Torres, David; Rios-Serna, Lady J; Albornoz, Ludwig; Rosales, Joaquin D; Cañas, Carlos A; Adolfo Cruz-Suarez, Gustavo; Osorio, Felipe Ocampo; Fleitas, Tania; Laponogov, Ivan; Loukanov, Alexandre; Veselkov, Kirill

Year: 2025

Venue: Imperial College London

DOI: https://hdl.handle.net/10044/1/123120

Thesis Systematic interrogation of tumor cell resistance to CAR T cell therapy in pancreatic cancer

Hagel, Kimberly Rose · 2022 · Harvard University - DASH · DOI

Full title: Systematic interrogation of tumor cell resistance to CAR T cell therapy in pancreatic cancer

Authors: Hagel, Kimberly Rose

Year: 2022

Venue: Harvard University - DASH

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372137

Thesis Effects of Engineered Costimulation on the Function of T Cell Subsets

Boroughs, Angela C. · 2019 · Harvard University - DASH · DOI

Full title: Effects of Engineered Costimulation on the Function of T Cell Subsets

Authors: Boroughs, Angela C.

Year: 2019

Venue: Harvard University - DASH

DOI: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41121316

Thesis Synthetic Biology Approaches to Engineering Human Cells

Lohmueller, Jason Jakob · 2013 · Harvard University - DASH · DOI

Full title: Synthetic Biology Approaches to Engineering Human Cells

Authors: Lohmueller, Jason Jakob

Year: 2013

Venue: Harvard University - DASH

DOI: http://dissertations.umi.com/gsas.harvard:11030

Thesis Commercialisation strategies for formacyte therapeutics: assessment of potential indications by conducting pre-market validation through patient insights

Wiggins, Grace Sui-Ying · 2025 · Nanyang Technological University (NTU) · DOI

Full title: Commercialisation strategies for formacyte therapeutics: assessment of potential indications by conducting pre-market validation through patient insights

Authors: Wiggins, Grace Sui-Ying

Year: 2025

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/200958

Thesis Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors

Kosti, Paris; Opzoomer, James W; Larios-Martinez, Karen I et al. · 2021 · Utrecht University · DOI

Full title: Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors

Authors: Kosti, Paris; Opzoomer, James W; Larios-Martinez, Karen I; Henley-Smith, Rhonda; Scudamore, Cheryl L; Okesola, Mary; Taher, Mustafa Y M; Davies, David M; Muliaditan, Tamara; Larcombe-Young, Daniel; Woodman, Natalie; Gillett, Cheryl E; Thavaraj, Selvam; Maher, John; Arnold, James N

Year: 2021

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/416353

Thesis ARCOBALENO cell therapy to treat pediatric cancer patients

Lo Presti, Vania · 2022 · Utrecht University · DOI

Full title: ARCOBALENO cell therapy to treat pediatric cancer patients

Authors: Lo Presti, Vania

Year: 2022

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/416575

Thesis Are CAR-T therapies living up to their hype?: A study using real-world data in two cohorts to determine how well they are actually working in practice compared with bone marrow transplants

Schulthess, Duane; Gassull, Daniel; Makady, Amr et al. · 2021 · Utrecht University · DOI

Full title: Are CAR-T therapies living up to their hype?: A study using real-world data in two cohorts to determine how well they are actually working in practice compared with bone marrow transplants

Authors: Schulthess, Duane; Gassull, Daniel; Makady, Amr; Ludlow, Anna; Rothman, Brian; Have, Pieter Ten; Wu, Yiyang; Ekstrom, Leeland; Minnema, Monique; Jagasia, Madan

Year: 2021

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/438920

Thesis Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

Wachsmann, Tassilo L A; Wouters, Anne K; Remst, Dennis F G et al. · 2022 · Utrecht University · DOI

Full title: Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

Authors: Wachsmann, Tassilo L A; Wouters, Anne K; Remst, Dennis F G; Hagedoorn, Renate S; Meeuwsen, Miranda H; van Diest, Eline; Leusen, Jeanette; Kuball, Jürgen; Falkenburg, J H Frederik; Heemskerk, Mirjam H M

Year: 2022

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/445619

Thesis Delivering safer immunotherapies for cancer

Milling, Lauren Elizabeth; Irvine, Darrell J; Zhang, Yuan, Ph. D. Massachusetts Institute of Technology · 2018 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Delivering safer immunotherapies for cancer

Authors: Milling, Lauren Elizabeth; Irvine, Darrell J; Zhang, Yuan, Ph. D. Massachusetts Institute of Technology

Year: 2018

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/117754

Thesis Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses

Cho, Jang Hwan; Collins, James J.; Wong, Wilson W · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses

Authors: Cho, Jang Hwan; Collins, James J.; Wong, Wilson W

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/135450.2

Thesis Engineering advanced logic and distributed computing in human CAR immune cells

Cho, Jang Hwan; Okuma, Atsushi; Sofjan, Katri et al. · 2021 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Engineering advanced logic and distributed computing in human CAR immune cells

Authors: Cho, Jang Hwan; Okuma, Atsushi; Sofjan, Katri; Lee, Seunghee; Collins, James J; Wong, Wilson W

Year: 2021

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/136156

Thesis Sense-and-Respond Payload Delivery Using a Novel Antigen-Inducible Promoter Improves Suboptimal CAR-T Activation

Guo, Tingxi; Ma, Dacheng; Lu, Timothy K · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Sense-and-Respond Payload Delivery Using a Novel Antigen-Inducible Promoter Improves Suboptimal CAR-T Activation

Authors: Guo, Tingxi; Ma, Dacheng; Lu, Timothy K

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/143767

Thesis Enhancing Chimeric Antigen Receptor T cell therapy in Mouse EGFRvIII Heterogeneous Glioblastoma

Swan, Sheridan Leigh-Carroll · 2023 · Duke University · DOI

Full title: Enhancing Chimeric Antigen Receptor T cell therapy in Mouse EGFRvIII Heterogeneous Glioblastoma

Authors: Swan, Sheridan Leigh-Carroll

Year: 2023

Venue: Duke University

DOI: https://hdl.handle.net/10161/27581

Thesis Leveraging microRNAs for cellular therapy

Hasiuk, Marko; Dölz, Marianne; Marone, Romina et al. · 2025 · University of Basel - edoc Repository · DOI

Full title: Leveraging microRNAs for cellular therapy

Authors: Hasiuk, Marko; Dölz, Marianne; Marone, Romina; Jeker, Lukas T.

Year: 2025

Venue: University of Basel - edoc Repository

DOI: https://hdl.handle.net/20.500.14716/124025

Thesis Integrated analysis of immunotherapy treated clear cell renal cell carcinomas: An exploratory study

Sobottka, Bettina; Nienhold, Ronny; Nowak, Marta et al. · 2025 · University of Basel - edoc Repository · DOI

Full title: Integrated analysis of immunotherapy treated clear cell renal cell carcinomas: An exploratory study

Authors: Sobottka, Bettina; Nienhold, Ronny; Nowak, Marta; Hench, Juergen; Haeuptle, Pirmin; Frank, Angela; Sachs, Melanie; Kahraman, Abdullah; Moch, Holger; Koelzer, Viktor H.; Mertz, Kirsten D.

Year: 2025

Venue: University of Basel - edoc Repository

DOI: https://hdl.handle.net/20.500.14716/126697

Thesis Next Generation Receptors for the Enhanced Control of Cell-based Immunotherapies

Zhu, Iowis · 2021 · University of California, San Francisco (UCSF) · DOI

Full title: Next Generation Receptors for the Enhanced Control of Cell-based Immunotherapies

Authors: Zhu, Iowis

Year: 2021

Venue: University of California, San Francisco (UCSF)

DOI: https://escholarship.org/uc/item/0kj4035m

Thesis An autonomous microfluidic device for identification and analysis of individual clinically-relevant mammalian cells

Jammes, Fabien Louis Claude Robert · 2021 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: An autonomous microfluidic device for identification and analysis of individual clinically-relevant mammalian cells

Authors: Jammes, Fabien Louis Claude Robert

Year: 2021

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/182607

Thesis Rational design of protein switches: applications in synthetic biology and cancer immunotherapy

Shui, Sailan · 2022 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Rational design of protein switches: applications in synthetic biology and cancer immunotherapy

Authors: Shui, Sailan

Year: 2022

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/185608

Thesis Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

Sun, Jie; Tang, Li · 2024 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

Authors: Sun, Jie; Tang, Li

Year: 2024

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/205012

Thesis DEVELOPMENT OF AN NFAT-MEDIATED INDUCIBLE RETROVIRAL VECTOR SYSTEM IN CD19-TARGETED Vδ1 γδ T CELLS FOR ENHANCED CANCER IMMUNOTHERAPY

Wong, Jonathan Ta Shin · 2024 · Johns Hopkins University · DOI

Full title: DEVELOPMENT OF AN NFAT-MEDIATED INDUCIBLE RETROVIRAL VECTOR SYSTEM IN CD19-TARGETED Vδ1 γδ T CELLS FOR ENHANCED CANCER IMMUNOTHERAPY

Authors: Wong, Jonathan Ta Shin

Year: 2024

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/69898

Thesis DEVELOPMENT OF CHIMERIC ANTIGEN RECEPTOR T CELLS FOR TARGETING GENETIC ALTERATIONS IN CANCER

Mog, Brian · 2024 · Johns Hopkins University · DOI

Full title: DEVELOPMENT OF CHIMERIC ANTIGEN RECEPTOR T CELLS FOR TARGETING GENETIC ALTERATIONS IN CANCER

Authors: Mog, Brian

Year: 2024

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/69450

Thesis Turning CAR T therapy solid tumor infiltration into reality using synthetic velocity receptors

Johnston, Adrian · 2024 · Johns Hopkins University · DOI

Full title: Turning CAR T therapy solid tumor infiltration into reality using synthetic velocity receptors

Authors: Johnston, Adrian

Year: 2024

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/69504

Thesis Switching on the green light for chimeric antigen receptor T-cell therapy

Mardiana, S; Lai, J; House, IG et al. · 2020 · University of Melbourne · DOI

Full title: Switching on the green light for chimeric antigen receptor T-cell therapy

Authors: Mardiana, S; Lai, J; House, IG; Beavis, PA; Darcy, PK

Year: 2020

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/251190

Thesis Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

Davenport, AJ; Cross, RS; Watson, KA et al. · 2020 · University of Melbourne · DOI

Full title: Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

Authors: Davenport, AJ; Cross, RS; Watson, KA; Liao, Y; Shi, W; Prince, HM; Beavis, PA; Trapani, JA; Kershaw, MH; Ritchie, DS; Darcy, PK; Neeson, PJ; Jenkins, MR

Year: 2020

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/253195

Thesis Understanding T cell phenotype for the design of effective chimeric antigen receptor T cell therapies

Tantalo, DGM; Oliver, AJ; Von Scheidt, B et al. · 2021 · University of Melbourne · DOI

Full title: Understanding T cell phenotype for the design of effective chimeric antigen receptor T cell therapies

Authors: Tantalo, DGM; Oliver, AJ; Von Scheidt, B; Harrison, AJ; Mueller, SN; Kershaw, MH; Slaney, CY

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/278368

Thesis Chimeric antigen receptor t cell therapy and the immunosuppressive tumor microenvironment in pediatric sarcoma

Terry, RL; Meyran, D; Fleuren, EDG et al. · 2022 · University of Melbourne · DOI

Full title: Chimeric antigen receptor t cell therapy and the immunosuppressive tumor microenvironment in pediatric sarcoma

Authors: Terry, RL; Meyran, D; Fleuren, EDG; Mayoh, C; Zhu, J; Omer, N; Ziegler, DS; Haber, M; Darcy, PK; Trapani, JA; Neeson, PJ; Ekert, PG

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/296907

Thesis The evolving protein engineering in the design of chimeric antigen receptor T cells

Hughes-Parry, HE; Cross, RS; Jenkins, MR · 2022 · University of Melbourne · DOI

Full title: The evolving protein engineering in the design of chimeric antigen receptor T cells

Authors: Hughes-Parry, HE; Cross, RS; Jenkins, MR

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/304400

Thesis Finding the keys to the CAR: Identifying novel target antigens for t cell redirection immunotherapies

Abbott, RC; Cross, RS; Jenkins, MR · 2022 · University of Melbourne · DOI

Full title: Finding the keys to the CAR: Identifying novel target antigens for t cell redirection immunotherapies

Authors: Abbott, RC; Cross, RS; Jenkins, MR

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/304402

Thesis Left out in the cold: Moving beyond hormonal therapy for the treatment of immunologically cold prostate cancer with CAR T cell immunotherapies

Porter, LH; Harrison, SG; Risbridger, GP et al. · 2024 · University of Melbourne · DOI

Full title: Left out in the cold: Moving beyond hormonal therapy for the treatment of immunologically cold prostate cancer with CAR T cell immunotherapies

Authors: Porter, LH; Harrison, SG; Risbridger, GP; Lister, N; Taylor, RA

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/349476

Thesis A systematic review of economic evaluations of advanced therapy medicinal products

Lloyd-Williams, Huw; Hughes, Dyfrig A · 2021 · University of Liverpool · DOI

Full title: A systematic review of economic evaluations of advanced therapy medicinal products

Authors: Lloyd-Williams, Huw; Hughes, Dyfrig A

Year: 2021

Venue: University of Liverpool

DOI: oai:livrepository.liverpool.ac.uk:3130128

Thesis CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma

Pal, SK; Tran, B; Haanen, JBAG et al. · 2024 · University of Melbourne · DOI

Full title: CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma

Authors: Pal, SK; Tran, B; Haanen, JBAG; Hurwitz, ME; Sacher, A; Tannir, NM; Budde, LE; Harrison, SJ; Klobuch, S; Patel, SS; Meza, L; Dequeant, ML; Ma, A; He, QA; Williams, LM; Keegan, A; Gurary, EB; Dar, H; Karnik, S; Guo, C; Heath, H; Yuen, RR; Morrow, PK; Agarwal, N; Srour, SA

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/351503

Thesis Antibody with Infinite Affinity for In Vivo Tracking of Genetically Engineered Lymphocytes.

Krebs, Simone; Ahad, Afruja; Carter, Lukas M et al. · 2018 · Technical University of Munich (TUM) · DOI

Full title: Antibody with Infinite Affinity for In Vivo Tracking of Genetically Engineered Lymphocytes.

Authors: Krebs, Simone;Ahad, Afruja;Carter, Lukas M;Eyquem, Justin;Brand, Christian;Bell, Meghan;Ponomarev, Vladimir;Reiner, Thomas;Meares, Claude F;Gottschalk, Stephen;Sadelain, Michel;Larson, Steven M;Weber, Wolfgang A

Year: 2018

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1589425

Thesis T cell engineering for adoptive T cell therapy: safety and receptor avidity.

D'Ippolito, Elvira; Schober, Kilian; Nauerth, Magdalena et al. · 2019 · Technical University of Munich (TUM) · DOI

Full title: T cell engineering for adoptive T cell therapy: safety and receptor avidity.

Authors: D'Ippolito, Elvira;Schober, Kilian;Nauerth, Magdalena;Busch, Dirk H

Year: 2019

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1590619

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SCAN-ACT: adoptive T cell therapy target discovery through single-cell transcriptomics

Stefano Testa; Aastha Pal; A. Subramanian et al. · 2025

Full title: SCAN-ACT: adoptive T cell therapy target discovery through single-cell transcriptomics

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Current challenges and therapeutic advances of CAR-T cell therapy for solid tumors

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Full title: Current challenges and therapeutic advances of CAR-T cell therapy for solid tumors

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The Notch signaling pathway: a potential target for cancer immunotherapy

Li, Xinxin; Yan, Xianchun; Wang, Yufeng et al. · 2023

Full title: The Notch signaling pathway: a potential target for cancer immunotherapy

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SCAN-ACT: adoptive T cell therapy target discovery through single-cell transcriptomics

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Full title: SCAN-ACT: adoptive T cell therapy target discovery through single-cell transcriptomics

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Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system

Kipniss, Nathan H.; Dingal, P.C. Dave P.; Abbott, Timothy R. et al. · 2017

Full title: Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system

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CAR T cell design: approaching the elusive AND-gate

Zeguo Zhao; M. Sadelain · 2023

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Castellarin, Mauro; Watanabe, Keisuke; June, Carl H. et al. · 2018

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Development of NK cell-based cancer immunotherapies through receptor engineering

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On-target restoration of a split T cell-engaging antibody for precision immunotherapy

Banaszek, Agnes; Bumm, Thomas G.P.; Nowotny, Boris et al. · 2019

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The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity

Helsen, Christopher W.; Hammill, Joanne A.; Lau, Vivian Wing Chong et al. · 2018

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Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma

Hsiang-Chi, Tseng; Xiong, Wei; Badeti, Saiaditya et al. · 2020

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Engineering advanced logic and distributed computing in human CAR immune cells

J. Cho; Atsushi Okuma; Katri Sofjan et al. · 2021

Full title: Engineering advanced logic and distributed computing in human CAR immune cells

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Hwang, Michael S.; Miller, Michelle S.; Thirawatananond, Puchong et al. · 2021

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Microenvironment-confined kinetic elucidation and implementation of a DNA nano-phage with a shielded internal computing layer

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Full title: Microenvironment-confined kinetic elucidation and implementation of a DNA nano-phage with a shielded internal computing layer

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Universal redirection of CAR T cells against solid tumours via membrane-inserted ligands for the CAR

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Ahmadi, Saba; Sukprasert, Pattara; Vegesna, Rahulsimham et al. · 2020

Full title: The Landscape of Receptor-Mediated Precision Cancer Combination Therapy: A Single-Cell Perspective

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Remote control of CAR T cell therapies by thermal targeting

Miller, Ian C.; Sun, Lee-Kai; Harris, Adrian M. et al. · 2020

Full title: Remote control of CAR T cell therapies by thermal targeting

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Full title: A functional screening platform for engineering chimeric antigen receptors with reduced on-target, off-tumour activation

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DOI: https://doi.org/10.1101/2021.05.21.445218

Paper

Clinically-driven design of synthetic gene regulatory programs in human cells

Israni, Divya V.; Li, Hui-Shan; Gagnon, Keith A. et al. · 2021

Full title: Clinically-driven design of synthetic gene regulatory programs in human cells

Authors: Israni, Divya V.; Li, Hui-Shan; Gagnon, Keith A.; Sander, Jeffry D.; Roybal, Kole T.; Joung, J. Keith; Wong, Wilson W.; Khalil, Ahmad S.

DOI: https://doi.org/10.1101/2021.02.22.432371

Paper

Discovery and validation of novel human genomic safe harbor sites for gene and cell therapies

Aznauryan, Erik; Yermanos, Alexander; Kinzina, Elvira et al. · 2021

Full title: Discovery and validation of novel human genomic safe harbor sites for gene and cell therapies

Authors: Aznauryan, Erik; Yermanos, Alexander; Kinzina, Elvira; Kapetanovic, Edo; Milanova, Denitsa; Church, George M.; Reddy, Sai T.

DOI: https://doi.org/10.1101/2021.03.04.433856

Paper

T cell circuits that sense antigen density with an ultrasensitive threshold

Hernández‐López, Rogelio A.; Yu, Wei; Cabral, Katelyn A. et al. · 2021

Full title: T cell circuits that sense antigen density with an ultrasensitive threshold

DOI: https://doi.org/10.1126/science.abc1855

Paper

Engineering chimeric antigen receptor-T cells for cancer treatment

Ye, Baixin; Stary, Creed M.; Li, Xuejun et al. · 2018

Full title: Engineering chimeric antigen receptor-T cells for cancer treatment

Authors: Ye, Baixin; Stary, Creed M.; Li, Xuejun; Qingping, Gao; Kang, Chunsheng; Xiong, Xiaoxing

DOI: https://doi.org/10.1186/s12943-018-0814-0

Paper

Chimeric antigen receptor T cells: a novel therapy for solid tumors

Yu, Shengnan; Li, Anping; Liu, Qian et al. · 2017

Full title: Chimeric antigen receptor T cells: a novel therapy for solid tumors

Authors: Yu, Shengnan; Li, Anping; Liu, Qian; Li, Tengfei; Yuan, Xun; Han, Xinwei; Wu, Kongming

DOI: https://doi.org/10.1186/s13045-017-0444-9

Paper

CAR-T cells and BiTEs in solid tumors: challenges and perspectives

Edeline, Julien; Houot, Roch; Marabelle, Aurélien et al. · 2021

Full title: CAR-T cells and BiTEs in solid tumors: challenges and perspectives

Authors: Edeline, Julien; Houot, Roch; Marabelle, Aurélien; Alcantara, Marion

DOI: https://doi.org/10.1186/s13045-021-01067-5

Paper

PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivo

Qibin Liao; Yunyu Mao; Huan He et al. · 2020

Full title: PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivo

Authors: Qibin Liao; Yunyu Mao; Huan He; Xiangqing Ding; Xiaoyan Zhang; Jianqing Xu

DOI: https://doi.org/10.1186/s40364-020-00237-w

Paper

Identification of cancer-specific cell surface targets for CAR-T cell therapy

Hosen, Naoki · 2024

Full title: Identification of cancer-specific cell surface targets for CAR-T cell therapy

Authors: Hosen, Naoki

DOI: https://doi.org/10.1186/s41232-024-00329-2

Paper

Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma

Hsiang-Chi, Tseng; Xiong, Wei; Badeti, Saiaditya et al. · 2020

Full title: Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma

DOI: https://doi.org/10.1038/s41467-020-18444-2

Paper

Coopting T cell proximal signaling molecules enables Boolean logic-gated CAR T cell control

Aidan M Tousley; M. Rotiroti; Louai Labanieh et al. · 2022

Full title: Coopting T cell proximal signaling molecules enables Boolean logic-gated CAR T cell control

DOI: https://doi.org/10.1101/2022.06.17.496457

Paper

Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors

Johnston, Adrian; Alicea, Gretchen M.; Lee, Cameron et al. · 2023

Full title: Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors

DOI: https://doi.org/10.1101/2023.12.13.571595

Paper

Compact Programmable Control of Protein Secretion in Mammalian Cells

Vlahos, Alexander E.; Call, Connor C.; Kadaba, Samarth E. et al. · 2023

Full title: Compact Programmable Control of Protein Secretion in Mammalian Cells

Authors: Vlahos, Alexander E.; Call, Connor C.; Kadaba, Samarth E.; Guo, Siqi; Gao, Xiaojing

DOI: https://doi.org/10.1101/2023.10.04.560774

Paper

A synthetic notch (synNotch) system linking intratumoral immune-cancer cell communication to a synthetic blood biomarker assay

Fu, Yanghao; Wang, TianDuo; Ronald, John A. · 2023

Full title: A synthetic notch (synNotch) system linking intratumoral immune-cancer cell communication to a synthetic blood biomarker assay

Authors: Fu, Yanghao; Wang, TianDuo; Ronald, John A.

DOI: https://doi.org/10.3389/fphar.2023.1304194

Paper

De novo -designed minibinders expand the synthetic biology sensing repertoire

Weinberg, Zara Y.; Soliman, Sarah S.; Kim, Matthew S. et al. · 2024

Full title: De novo -designed minibinders expand the synthetic biology sensing repertoire

Authors: Weinberg, Zara Y.; Soliman, Sarah S.; Kim, Matthew S.; Shah, Devan H; Chen, Irene P.; Ott, Mélanie; Lim, Wendell A.; El‐Samad, Hana

DOI: https://doi.org/10.1101/2024.01.12.575267

Paper

Synthetic Cellular Immunity based on CAR repertoire for Human Immunotherapy

Fu, Wenyan; Wang, Chuqi; Ma, Zetong et al. · 2019

Full title: Synthetic Cellular Immunity based on CAR repertoire for Human Immunotherapy

Authors: Fu, Wenyan; Wang, Chuqi; Ma, Zetong; Tian, Li; Lin, Fangxing; Mao, Ruixue; Lei, Changhai; Zhao, Jian; Hu, Shi

DOI: https://doi.org/10.1101/868653

Paper

Special Chimeric Antigen Receptor (CAR) Modifications of T Cells: A Review

Miao, Lele; Zhang, Juan; Huang, Binjie et al. · 2022

Full title: Special Chimeric Antigen Receptor (CAR) Modifications of T Cells: A Review

Authors: Miao, Lele; Zhang, Juan; Huang, Binjie; Zhang, Zhengchao; Wang, Song; Tang, Futian; Teng, Muzhou; Li, Yumin

DOI: https://doi.org/10.3389/fonc.2022.832765

Paper

Research advances in chimeric antigen receptor-modified T-cell therapy (Review)

Luo, Yuxi; Song, Guiqin; Liang, Shichu et al. · 2021

Full title: Research advances in chimeric antigen receptor-modified T-cell therapy (Review)

Authors: Luo, Yuxi; Song, Guiqin; Liang, Shichu; Li, Feifei; Liu, Kang

DOI: https://doi.org/10.3892/etm.2021.9915

Paper

Revealing Facts About CAR-T Cell Therapy

Padmanjali, Daggupati Sai; Revathi, Boyina; Jalaiah, M · 2022

Full title: Revealing Facts About CAR-T Cell Therapy

Authors: Padmanjali, Daggupati Sai; Revathi, Boyina; Jalaiah, M

DOI: https://doi.org/10.34172/ia.2022.06

Paper

The application of prostate specific membrane antigen in CART‑cell therapy for treatment of prostate carcinoma (Review)

Ullah, Kifayat; Addai, Frank Peprah; Yu, Feng et al. · 2018

Full title: The application of prostate specific membrane antigen in CART‑cell therapy for treatment of prostate carcinoma (Review)

Authors: Ullah, Kifayat; Addai, Frank Peprah; Yu, Feng; Shi, Haifeng

DOI: https://doi.org/10.3892/or.2018.6758

Paper

A long way to the battlefront: CAR T cell therapy against solid cancers

Wang, Zhicai; Chen, Wei; Zhang, Xing et al. · 2019

Full title: A long way to the battlefront: CAR T cell therapy against solid cancers

Authors: Wang, Zhicai; Chen, Wei; Zhang, Xing; Cai, Zhiming; Huang, Weiren

DOI: https://doi.org/10.7150/jca.30406

Paper

Precise surface functionalization of PLGA particles for human T cell modulation

Hadley, Pierce; Chen, Yuanzhou; Cline, Lariana et al. · 2023

Full title: Precise surface functionalization of PLGA particles for human T cell modulation

Authors: Hadley, Pierce; Chen, Yuanzhou; Cline, Lariana; Han, Zhiyuan; Tang, Qizhi; Huang, Xiao; Desai, Tejal A.

DOI: https://doi.org/10.21203/rs.3.pex-2337/v1

Paper

CHIMERIC ANTIGEN RECEPTOR FOR CHRONIC LYMPHOCYTIC LEUKEMIA - A REVIEW

Raghunathan, Kiruthiga; Devi, Parthiban Brindha · 2019

Full title: CHIMERIC ANTIGEN RECEPTOR FOR CHRONIC LYMPHOCYTIC LEUKEMIA - A REVIEW

Authors: Raghunathan, Kiruthiga; Devi, Parthiban Brindha

DOI: https://doi.org/10.22159/ajpcr.2018.v12i1.29642

Paper

Perspectives on Chimeric Antigen Receptor T-Cell Immunotherapy for Solid Tumors

Kosti, Paris; Maher, John; Arnold, James N. · 2018

Full title: Perspectives on Chimeric Antigen Receptor T-Cell Immunotherapy for Solid Tumors

Authors: Kosti, Paris; Maher, John; Arnold, James N.

DOI: https://doi.org/10.3389/fimmu.2018.01104

Paper

Emerging Approaches for Regulation and Control of CAR T Cells: A Mini Review

Brandt, Lærke Josefine Baunsgaard; Barnkob, Mike Bogetofte; Michaels, Yale S. et al. · 2020

Full title: Emerging Approaches for Regulation and Control of CAR T Cells: A Mini Review

Authors: Brandt, Lærke Josefine Baunsgaard; Barnkob, Mike Bogetofte; Michaels, Yale S.; Heiselberg, Julia; Barington, Torben

DOI: https://doi.org/10.3389/fimmu.2020.00326

Paper

Obstacles and Coping Strategies of CAR-T Cell Immunotherapy in Solid Tumors

Miao, Lele; Zhang, Zhengchao; Ren, Zhijian et al. · 2021

Full title: Obstacles and Coping Strategies of CAR-T Cell Immunotherapy in Solid Tumors

Authors: Miao, Lele; Zhang, Zhengchao; Ren, Zhijian; Tang, Futian; Li, Yumin

DOI: https://doi.org/10.3389/fimmu.2021.687822

Paper

From barriers to novel strategies: smarter CAR T therapy hits hard to tumors

Khawar, Muhammad Babar; Ge, Fei; Afzal, Ali et al. · 2023

Full title: From barriers to novel strategies: smarter CAR T therapy hits hard to tumors

Authors: Khawar, Muhammad Babar; Ge, Fei; Afzal, Ali; Sun, Haibo

DOI: https://doi.org/10.3389/fimmu.2023.1203230

Paper

Targeting colorectal cancer cells using AND-gated adaptor RevCAR T-cells

Soto, Karla Elizabeth González; Loureiro, Liliana R.; Bartsch, Tabea et al. · 2023

Full title: Targeting colorectal cancer cells using AND-gated adaptor RevCAR T-cells

DOI: https://doi.org/10.3389/fimmu.2023.1302354

Paper

Comprehensive clinical evaluation of CAR-T cell immunotherapy for solid tumors: a path moving forward or a dead end?

Drougkas, Konstantinos; Karampinos, Konstantinos; Karavolias, Ioannis et al. · 2022

Full title: Comprehensive clinical evaluation of CAR-T cell immunotherapy for solid tumors: a path moving forward or a dead end?

DOI: https://doi.org/10.1007/s00432-022-04547-4

Paper

Treatment of solid tumors with chimeric antigen receptor-engineered T cells: current status and future prospects

Di, Shengmeng; Li, Zonghai · 2016

Full title: Treatment of solid tumors with chimeric antigen receptor-engineered T cells: current status and future prospects

Authors: Di, Shengmeng; Li, Zonghai

DOI: https://doi.org/10.1007/s11427-016-5025-6

Paper

Chimeric Antigen Receptor-T Cells for Targeting Solid Tumors: Current Challenges and Existing Strategies

Springuel, Lorraine; Lonez, Caroline; Alexandre, Bertrand et al. · 2019

Full title: Chimeric Antigen Receptor-T Cells for Targeting Solid Tumors: Current Challenges and Existing Strategies

DOI: https://doi.org/10.1007/s40259-019-00368-z

Paper

Cytotoxic CD8+ T cells in cancer and cancer immunotherapy

Raskov, Hans; Orhan, Adile; Christensen, Jan Pravsgaard et al. · 2020

Full title: Cytotoxic CD8+ T cells in cancer and cancer immunotherapy

Authors: Raskov, Hans; Orhan, Adile; Christensen, Jan Pravsgaard; Gögenür, Ismail

DOI: https://doi.org/10.1038/s41416-020-01048-4

Paper

New Strategies for the Treatment of Solid Tumors with CAR-T Cells

Zhang, Hao; Ye, Zhenlong; Yuan, Zhen-Gang et al. · 2016

Full title: New Strategies for the Treatment of Solid Tumors with CAR-T Cells

Authors: Zhang, Hao; Ye, Zhenlong; Yuan, Zhen-Gang; Luo, Zheng-qiang; Jin, Huajun; Qian, Qijun

DOI: https://doi.org/10.7150/ijbs.14405

Thesis

Cancer Immunotherapy : Evolving Oncolytic viruses and CAR T-cells

Ramachandran, Mohanraj · 2016

Full title: Cancer Immunotherapy : Evolving Oncolytic viruses and CAR T-cells

Authors: Ramachandran, Mohanraj

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-302891

Thesis

Development of mechanogenetic tools for subcellular applications in cancer immunotherapy

Pan, Yijia · 2018

Full title: Development of mechanogenetic tools for subcellular applications in cancer immunotherapy

Authors: Pan, Yijia

DOI: https://escholarship.org/uc/item/1nd242wb

Thesis

Molecular and Cellular Engineering to Guide CAR T Cell Therapy through the Immunosuppressive Tumor Microenvironment

Man, Chi-Wei · 2022

Full title: Molecular and Cellular Engineering to Guide CAR T Cell Therapy through the Immunosuppressive Tumor Microenvironment

Authors: Man, Chi-Wei

DOI: https://escholarship.org/uc/item/2v29x1p9

Thesis

Engineering Molecular Modules Through Directed Evolution for Applications in Single-Cell Imaging and Immunotherapy

Limsakul, Praopim · 2019

Full title: Engineering Molecular Modules Through Directed Evolution for Applications in Single-Cell Imaging and Immunotherapy

Authors: Limsakul, Praopim

DOI: https://escholarship.org/uc/item/7x01b05n

Thesis

Systems Immune Profiling Elucidates Therapeutic Vulnerabilities and Enhancements for Viral and Engineered Tumor Immunity

Burnett, Cassandra Eve · 2023

Full title: Systems Immune Profiling Elucidates Therapeutic Vulnerabilities and Enhancements for Viral and Engineered Tumor Immunity

Authors: Burnett, Cassandra Eve

DOI: https://escholarship.org/uc/item/98n328x0

Thesis

Combining TIL and CAR for adoptive cell therapy in metastatic melanoma

Mills, Jane Kathleen · 2019

Full title: Combining TIL and CAR for adoptive cell therapy in metastatic melanoma

Authors: Mills, Jane Kathleen

DOI: http://hdl.handle.net/11343/228933

Thesis

Understanding the role of adenosine receptor signalling in chimeric antigen receptor (CAR) T cell therapy in solid cancer

Sek, Kevin Chen Ming · 2021

Full title: Understanding the role of adenosine receptor signalling in chimeric antigen receptor (CAR) T cell therapy in solid cancer

Authors: Sek, Kevin Chen Ming

DOI: http://hdl.handle.net/11343/282479

Thesis

Engineering Chimeric Antigen Receptor T Cell Therapy for Glioblastoma

Abbott, Rebecca Caitlyn · 2023

Full title: Engineering Chimeric Antigen Receptor T Cell Therapy for Glioblastoma

Authors: Abbott, Rebecca Caitlyn

DOI: https://hdl.handle.net/11343/326532

Thesis

CRISPR/Cas9 Engineering of Next Generation Armoured CAR T Cells

Chen, Amanda Xi Ying · 2024

Full title: CRISPR/Cas9 Engineering of Next Generation Armoured CAR T Cells

Authors: Chen, Amanda Xi Ying

DOI: https://hdl.handle.net/11343/339525

Thesis

COMBINING IAP ANTAGONISTS WITH CAR T CELL THERAPY TO TREAT GLIOBLASTOMA: THE IAP ANTAGONIST BIRINAPANT ENHANCES CHIMERIC ANTIGEN RECEPTOR T CELL THERAPY FOR GLIOBLASTOMA BY OVERCOMING ANTIGEN HETEROGENEITY

Song, Edward, Zeyuan · 2024

Authors: Song, Edward, Zeyuan

DOI: https://repository.upenn.edu/handle/20.500.14332/59711

Thesis

Cancer Immunotherapy

Zhang, Yu · 2024

Full title: Cancer Immunotherapy

Authors: Zhang, Yu

DOI: https://openscholar.uga.edu/record/4772/files/ZhangYuMS-Revised.pdf

Thesis

Expression of a Chimeric Coreceptor Enhances the Antitumor Immunity of CD22-Targeted CAR-T Cells

Asby, Nicholas · 2024

Full title: Expression of a Chimeric Coreceptor Enhances the Antitumor Immunity of CD22-Targeted CAR-T Cells

Authors: Asby, Nicholas

DOI: https://knowledge.uchicago.edu/record/12993/files/Dissertation.pdf

Thesis

CAR T-Cell Therapy for Cancer: Latest Updates and Challenges, with a Focus on B-Lymphoid Malignancies and Selected Solid Tumours

Tang, Hiu Kwan Carolyn; email: ht8000@my.bristol.ac.uk; Wang, Bo et al. · 2023

Full title: CAR T-Cell Therapy for Cancer: Latest Updates and Challenges, with a Focus on B-Lymphoid Malignancies and Selected Solid Tumours

DOI: https://www.repository.cam.ac.uk/handle/1810/354966

Thesis

A decade of marketing approval of gene and cell-based therapies in the United States, European Union and Japan: An evaluation of regulatory decision-making

Coppens, D G M; de Wilde, S.; Guchelaar, H.J. et al. · 2018

Full title: A decade of marketing approval of gene and cell-based therapies in the United States, European Union and Japan: An evaluation of regulatory decision-making

Authors: Coppens, D G M; de Wilde, S.; Guchelaar, H.J.; De Bruin, M L; Leufkens, H G M; Meij, Pauline; Hoekman, J

DOI: https://dspace.library.uu.nl/handle/1874/369040

Thesis

Cellular heterogeneity mediates inherent sensitivity–specificity tradeoff in cancer targeting by synthetic circuits

Morel, Mathieu; Shtrahman, Roman; Rotter, Varda et al. · 2018

Full title: Cellular heterogeneity mediates inherent sensitivity–specificity tradeoff in cancer targeting by synthetic circuits

Authors: Morel, Mathieu; Shtrahman, Roman; Rotter, Varda; Nissim, Lior; Bar-Ziv, Roy H.

DOI: http://hdl.handle.net/1721.1/115130

Thesis

Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses

Cho, Jang Hwan; Collins, James J; Wong, Wilson W · 2021

Full title: Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses

Authors: Cho, Jang Hwan; Collins, James J; Wong, Wilson W

DOI: https://hdl.handle.net/1721.1/135450

Thesis

Visualization of the Underlying Kinetics of LckY394F and its Applications in CAR T-cell Therapy

Wei, Jiaming · 2019

Full title: Visualization of the Underlying Kinetics of LckY394F and its Applications in CAR T-cell Therapy

Authors: Wei, Jiaming

DOI: https://escholarship.org/uc/item/3286n8r2

Thesis

Developing thermo-activatable genetic circuits for immunotherapy

SONG, CHUNYANG · 2022

Full title: Developing thermo-activatable genetic circuits for immunotherapy

Authors: SONG, CHUNYANG

DOI: https://escholarship.org/uc/item/9kb2590t

Thesis

A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

Giordano-Attianese, Greta; Gainza, Pablo; Gray-Gaillard, Elise et al. · 2020

Full title: A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

DOI: https://infoscience.epfl.ch/handle/20.500.14299/166849

Thesis

Novel high-affinity EGFRvIII-specific chimeric antigen receptor T cells effectively eliminate human glioblastoma

Abbott, RC; Verdon, DJ; Gracey, FM et al. · 2021

Full title: Novel high-affinity EGFRvIII-specific chimeric antigen receptor T cells effectively eliminate human glioblastoma

Authors: Abbott, RC; Verdon, DJ; Gracey, FM; Hughes-Parry, HE; Iliopoulos, M; Watson, KA; Mulazzani, M; Luong, K; D’Arcy, C; Sullivan, LC; Kiefel, BR; Cross, RS; Jenkins, MR

DOI: https://hdl.handle.net/11343/278219

Thesis

To go or not to go? Biological logic gating engineered T cells

Abbott, RC; Hughes-Parry, HE; Jenkins, MR · 2022

Full title: To go or not to go? Biological logic gating engineered T cells

Authors: Abbott, RC; Hughes-Parry, HE; Jenkins, MR

DOI: https://hdl.handle.net/11343/307209

Thesis

Cancer Signals-Triggered T Cell Immunotherapy for Solid Tumors

Nguyen, Huong Thi Xuan · 2022

Full title: Cancer Signals-Triggered T Cell Immunotherapy for Solid Tumors

Authors: Nguyen, Huong Thi Xuan

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=case1662724663164312

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