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Car T Cell Expansion Process Parameters

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Paper The next frontier in immunotherapy: potential and challenges of CAR-macrophages

Li, Jing; Chen, Ping; Ma, Wenxue · 2024 · Experimental Hematology and Oncology · DOI

Full title: The next frontier in immunotherapy: potential and challenges of CAR-macrophages

Authors: Li, Jing; Chen, Ping; Ma, Wenxue

Year: 2024

Venue: Experimental Hematology and Oncology

DOI: https://doi.org/10.1186/s40164-024-00549-9

Paper Towards a commercial process for the manufacture of genetically modified T cells for therapy

Kaiser, A.; Assenmacher, Mario; Schröder, Bernd et al. · 2015 · Cancer Gene Therapy · DOI

Full title: Towards a commercial process for the manufacture of genetically modified T cells for therapy

Authors: Kaiser, A.; Assenmacher, Mario; Schröder, Bernd; Meyer, Marku S; Orentas, Rimas J.; Bethke, Ulf; Dropulić, Boro

Year: 2015

Venue: Cancer Gene Therapy

DOI: https://doi.org/10.1038/cgt.2014.78

Paper Understanding of molecular mechanisms in natural killer cell therapy

Yoon, Suk Ran; Kim, Tae‐Don; Choi, Inpyo · 2015 · Experimental & Molecular Medicine · DOI

Full title: Understanding of molecular mechanisms in natural killer cell therapy

Authors: Yoon, Suk Ran; Kim, Tae‐Don; Choi, Inpyo

Year: 2015

Venue: Experimental & Molecular Medicine

DOI: https://doi.org/10.1038/emm.2014.114

Paper 4-1BB immunotherapy: advances and hurdles

Singh, Rohit Kumar; Kim, Young Ho; Lee, Sang-Jin et al. · 2024 · Experimental & Molecular Medicine · DOI

Full title: 4-1BB immunotherapy: advances and hurdles

Authors: Singh, Rohit Kumar; Kim, Young Ho; Lee, Sang-Jin; Eom, Hyeon‐Seok; Choi, Beom K.

Year: 2024

Venue: Experimental & Molecular Medicine

DOI: https://doi.org/10.1038/s12276-023-01136-4

Paper Culture expansion of CAR T cells results in aberrant DNA methylation that is associated with adverse clinical outcome

L. Salz; Alexander Seitz; D. Schäfer et al. · 2023 · Leukemia · DOI

Full title: Culture expansion of CAR T cells results in aberrant DNA methylation that is associated with adverse clinical outcome

Authors: L. Salz; Alexander Seitz; D. Schäfer; Julia Franzen; T. Holzer; C. García-Prieto; I. Bürger; O. Hardt; M. Esteller; W. Wagner

Year: 2023

Venue: Leukemia

DOI: https://doi.org/10.1038/s41375-023-01966-1

Paper Optimized T-cell receptor-mimic chimeric antigen receptor T cells directed toward the intracellular Wilms Tumor 1 antigen

Rafiq, Sarwish; Purdon, Terence J.; Daniyan, Anthony F. et al. · 2016 · Leukemia · DOI

Full title: Optimized T-cell receptor-mimic chimeric antigen receptor T cells directed toward the intracellular Wilms Tumor 1 antigen

Authors: Rafiq, Sarwish; Purdon, Terence J.; Daniyan, Anthony F.; Koneru, Mythili; Dao, Tao; Liu, C; Scheinberg, David A.; Brentjens, Renier J.

Year: 2016

Venue: Leukemia

DOI: https://doi.org/10.1038/leu.2016.373

Paper Phase 1 clinical trial of B-Cell Maturation Antigen (BCMA) NEX-T® Chimeric Antigen Receptor (CAR) T cell therapy CC-98633/BMS-986354 in participants with triple-class exposed multiple myeloma

G. Ravi; S. Richard; Shaji K. Kumar et al. · 2025 · Leukemia · DOI

Full title: Phase 1 clinical trial of B-Cell Maturation Antigen (BCMA) NEX-T® Chimeric Antigen Receptor (CAR) T cell therapy CC-98633/BMS-986354 in participants with triple-class exposed multiple myeloma

Authors: G. Ravi; S. Richard; Shaji K. Kumar; S. Atrash; Michaela Liedtke; G. Kaur; B. Derman; P. L. Bergsagel; S. Mailankody; P. McCarthy; Alok Shrestha; Lisa Kelly; Thomas Ly; Sharmila Das; J. Thorpe; Alison Maier; Divya Varun; G. Navarro; Michael R. Burgess; Kristen Hege; A. Koegel; Luciano J. Costa

Year: 2025

Venue: Leukemia

DOI: https://doi.org/10.1038/s41375-025-02518-5

Paper CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression

Fousek, Kristen; Watanabe, Junji; Joseph, Sujith K. et al. · 2020 · Leukemia · DOI

Full title: CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression

Authors: Fousek, Kristen; Watanabe, Junji; Joseph, Sujith K.; George, Ann; An, Xingyue; Byrd, Tiara T.; Morris, Jessica S.; Luong, Annie; Martinez-Paniagua, Melisa; Sanber, Khaled; Navai, Shoba A.; Gad, Ahmed Z.; Salsman, Vita S.; Mathew, Pretty; Kim, Hye Na; Wagner, Dimitrios L.; Brunetti, Lorenzo; Jang, Albert; Baker, Matthew L.; Varadarajan, Navin; Hegde, Meenakshi; Kim, Yong‐Mi; Heisterkamp, Nora; Abdel‐Azim, Hisham; Ahmed, Nabil

Year: 2020

Venue: Leukemia

DOI: https://doi.org/10.1038/s41375-020-0792-2

Paper Signaling pathways in the regulation of cytokine release syndrome in human diseases and intervention therapy

Li, Xia; Shao, Mi; Zeng, Xiangjun et al. · 2021 · Signal Transduction and Targeted Therapy · DOI

Full title: Signaling pathways in the regulation of cytokine release syndrome in human diseases and intervention therapy

Authors: Li, Xia; Shao, Mi; Zeng, Xiangjun; Qian, Pengxu; Huang, He

Year: 2021

Venue: Signal Transduction and Targeted Therapy

DOI: https://doi.org/10.1038/s41392-021-00764-4

Paper A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis

Ma, Qizhi; He, Xia; Zhang, Benxia et al. · 2022 · Signal Transduction and Targeted Therapy · DOI

Full title: A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis

Authors: Ma, Qizhi; He, Xia; Zhang, Benxia; Guo, Fuchun; Ou, Xuejin; Yang, Qiyu; Shu, Pei; Chen, Yue; Li, Kai; Gao, Ge; Zhu, Yajuan; Qin, Diyuan; Tang, Jie; Li, Xiaoyu; Meng, Jing; Zhao, Jian; Mo, Zeming; Liu, Ning; Zeng, Yao; Zhou, Kexun; Feng, Mingyang; Liao, Wei‐Ting; Lei, Wanting; Li, Qiu; Li, Dan; Wang, Yongsheng

Year: 2022

Venue: Signal Transduction and Targeted Therapy

DOI: https://doi.org/10.1038/s41392-022-01198-2

Paper CAR T-cell therapy in multiple myeloma: more room for improvement

Teoh, Phaik Ju; Chng, Wee Joo · 2021 · Blood Cancer Journal · DOI

Full title: CAR T-cell therapy in multiple myeloma: more room for improvement

Authors: Teoh, Phaik Ju; Chng, Wee Joo

Year: 2021

Venue: Blood Cancer Journal

DOI: https://doi.org/10.1038/s41408-021-00469-5

Paper Primary CD33-targeting CAR-NK cells for the treatment of acute myeloid leukemia

Albinger, Nawid; Pfeifer, Rita; Nitsche, Marcus et al. · 2022 · Blood Cancer Journal · DOI

Full title: Primary CD33-targeting CAR-NK cells for the treatment of acute myeloid leukemia

Authors: Albinger, Nawid; Pfeifer, Rita; Nitsche, Marcus; Mertlitz, Sarah; Campe, Julia; Stein, Katja; Kreyenberg, Hermann; Schubert, Ralf; Quadflieg, Melissa; Schneider, Dina; Kühn, Michael W.M.; Penack, Olaf; Zhang, Congcong; Möker, Nina; Ullrich, Evelyn

Year: 2022

Venue: Blood Cancer Journal

DOI: https://doi.org/10.1038/s41408-022-00660-2

Paper Allogenic and autologous anti-CD7 CAR-T cell therapies in relapsed or refractory T-cell malignancies

Zhang, Yinqiang; Li, Chenggong; Du, Mengyi et al. · 2023 · Blood Cancer Journal · DOI

Full title: Allogenic and autologous anti-CD7 CAR-T cell therapies in relapsed or refractory T-cell malignancies

Authors: Zhang, Yinqiang; Li, Chenggong; Du, Mengyi; Jiang, Huiwen; Luo, Wenjing; Tang, Lu; Kang, Yun Jin; Xu, Jia; Wu, Zhuolin; Wang, Xindi; Huang, Zhongpei; Zhang, Yanlei; Wu, Di; Chang, Alex H.; Hu, Yu; Mei, Heng

Year: 2023

Venue: Blood Cancer Journal

DOI: https://doi.org/10.1038/s41408-023-00822-w

Paper Next-day manufacture of a novel anti-CD19 CAR-T therapy for B-cell acute lymphoblastic leukemia: first-in-human clinical study

Yang, Junfang; He, Jiaping; Zhang, Xian et al. · 2022 · Blood Cancer Journal · DOI

Full title: Next-day manufacture of a novel anti-CD19 CAR-T therapy for B-cell acute lymphoblastic leukemia: first-in-human clinical study

Authors: Yang, Junfang; He, Jiaping; Zhang, Xian; Li, Jingjing; Wang, Zhenguang; Zhang, Yongliang; Qiu, Liyuan; Wu, Qionglu; Sun, Zhe; Ye, Xun; Yin, Wenjie; Cao, Wei; Shen, Lianjun; Sersch, Martina; Lu, Peihua

Year: 2022

Venue: Blood Cancer Journal

DOI: https://doi.org/10.1038/s41408-022-00694-6

Paper Novel CD19 chimeric antigen receptor T cells manufactured next-day for acute lymphoblastic leukemia

Cheng Zhang; Jiaping He; Li Liu et al. · 2022 · Blood Cancer Journal · DOI

Full title: Novel CD19 chimeric antigen receptor T cells manufactured next-day for acute lymphoblastic leukemia

Authors: Cheng Zhang; Jiaping He; Li Liu; Jishi Wang; Sanbin Wang; Ligen Liu; J. Ge; Lei Gao; Li Gao; P. Kong; Yao Liu; Jia Liu; Yu Han; Yongliang Zhang; Zhe Sun; Xun Ye; Wen-Juan Yin; M. Sersch; Lianjun Shen; W. Cao; Xi Zhang

Year: 2022

Venue: Blood Cancer Journal

DOI: https://doi.org/10.1038/s41408-022-00688-4

Paper Breakthrough of solid tumor treatment: CAR-NK immunotherapy

Wang, Wenkang; Liu, Yang; He, Zhen et al. · 2024 · Cell Death Discovery · DOI

Full title: Breakthrough of solid tumor treatment: CAR-NK immunotherapy

Authors: Wang, Wenkang; Liu, Yang; He, Zhen; Li, Lifeng; Liu, Senbo; Jiang, Mingqiang; Zhao, Bing; Deng, Meng; Wang, Wendong; Mi, Xuefang; Sun, Zhenqiang; Ge, Xin

Year: 2024

Venue: Cell Death Discovery

DOI: https://doi.org/10.1038/s41420-024-01815-9

Paper CAR-T cells: the long and winding road to solid tumors

D’Aloia, Maria Michela; Zizzari, Ilaria Grazia; Sacchetti, Benedetto et al. · 2018 · Cell Death and Disease · DOI

Full title: CAR-T cells: the long and winding road to solid tumors

Authors: D’Aloia, Maria Michela; Zizzari, Ilaria Grazia; Sacchetti, Benedetto; Pierelli, Luca; Alimandi, Maurizio

Year: 2018

Venue: Cell Death and Disease

DOI: https://doi.org/10.1038/s41419-018-0278-6

Paper CAR-T cell therapy: current limitations and potential strategies

Sterner, Robert C.; Sterner, Rosalie M. · 2021 · Blood Cancer Journal · DOI

Full title: CAR-T cell therapy: current limitations and potential strategies

Authors: Sterner, Robert C.; Sterner, Rosalie M.

Year: 2021

Venue: Blood Cancer Journal

DOI: https://doi.org/10.1038/s41408-021-00459-7

Paper Clinical development of CAR T cell therapy in China: 2020 update

Wei, Jianshu; Guo, Yelei; Wang, Yao et al. · 2020 · Cellular and Molecular Immunology · DOI

Full title: Clinical development of CAR T cell therapy in China: 2020 update

Authors: Wei, Jianshu; Guo, Yelei; Wang, Yao; Wu, Zhiqiang; Bo, Jian; Zhang, Bin; Zhu, Jun; Han, Weidong

Year: 2020

Venue: Cellular and Molecular Immunology

DOI: https://doi.org/10.1038/s41423-020-00555-x

Paper Signaling networks in immunometabolism

Saravia, Jordy; Raynor, Jana; Chapman, Nicole M. et al. · 2020 · Cell Research · DOI

Full title: Signaling networks in immunometabolism

Authors: Saravia, Jordy; Raynor, Jana; Chapman, Nicole M.; Lim, Seon Ah; Chi, Hongbo

Year: 2020

Venue: Cell Research

DOI: https://doi.org/10.1038/s41422-020-0301-1

Paper Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer

Xu, Yan; Xiang, Zheng; Alnaggar, Mohammed et al. · 2020 · Cellular and Molecular Immunology · DOI

Full title: Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer

Authors: Xu, Yan; Xiang, Zheng; Alnaggar, Mohammed; Kouakanou, Léonce; Li, Jiawei; He, Junyi; Yang, Jiashuang; Hu, Yi; Chen, Yan; Li, Lin; Hao, Jianlei; Li, Jingxia; Chen, Jibing; Li, Man; Wu, Qingling; Peters, Christian; Zhou, Qinghua; Li, Jianshuang; Liang, Yingqing; Wang, Xiaohua; Han, Baohui; Ma, Meili; Kabelitz, Dieter; Xu, Kecheng; Tu, Wenwei; Wu, Yangzhe; Yin, Zhinan

Year: 2020

Venue: Cellular and Molecular Immunology

DOI: https://doi.org/10.1038/s41423-020-0515-7

Paper Cancer immunotherapy with γδ T cells: many paths ahead of us

Kabelitz, Dieter; Serrano, Ruben; Kouakanou, Léonce et al. · 2020 · Cellular and Molecular Immunology · DOI

Full title: Cancer immunotherapy with γδ T cells: many paths ahead of us

Authors: Kabelitz, Dieter; Serrano, Ruben; Kouakanou, Léonce; Peters, Christian; Kalyan, Shirin

Year: 2020

Venue: Cellular and Molecular Immunology

DOI: https://doi.org/10.1038/s41423-020-0504-x

Paper Antitumor activity of EGFR-specific CAR T cells against non-small-cell lung cancer cells in vitro and in mice

Li, He; Huang, Yao; Jiang, Duqing et al. · 2018 · Cell Death and Disease · DOI

Full title: Antitumor activity of EGFR-specific CAR T cells against non-small-cell lung cancer cells in vitro and in mice

Authors: Li, He; Huang, Yao; Jiang, Duqing; Cui, Lianzhen; He, Zhou; Wang, Chao; Zhang, Zhiwei; Zhu, Haili; Ding, Yongmei; Li, Linfang; Li, Qiang; Jin, Huajun; Qian, Qijun

Year: 2018

Venue: Cell Death and Disease

DOI: https://doi.org/10.1038/s41419-017-0238-6

Paper Regulation of CD8+ T memory and exhaustion by the mTOR signals

Chen, Yao; Xu, Ziyang; Sun, Hongxiang et al. · 2023 · Cellular and Molecular Immunology · DOI

Full title: Regulation of CD8+ T memory and exhaustion by the mTOR signals

Authors: Chen, Yao; Xu, Ziyang; Sun, Hongxiang; Ouyang, Xinxing; Han, Yuheng; Yu, Haihui; Wu, Ningbo; Xie, Yiting; Su, Bing

Year: 2023

Venue: Cellular and Molecular Immunology

DOI: https://doi.org/10.1038/s41423-023-01064-3

Paper Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma

Zah, Eugenia; Nam, Eunwoo; Bhuvan, Vinya et al. · 2020 · Nature Communications · DOI

Full title: Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma

Authors: Zah, Eugenia; Nam, Eunwoo; Bhuvan, Vinya; Tran, Uyen; Ji, Brenda; Gosliner, Stanley B.; Wang, Xiuli; Brown, Christine E.; Chen, Yvonne Y.

Year: 2020

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-020-16160-5

Paper Driving cars to the clinic for solid tumors

Castellarin, Mauro; Watanabe, Keisuke; June, Carl H. et al. · 2018 · Gene Therapy · DOI

Full title: Driving cars to the clinic for solid tumors

Authors: Castellarin, Mauro; Watanabe, Keisuke; June, Carl H.; Kloss, Christopher C.; Posey, Avery D.

Year: 2018

Venue: Gene Therapy

DOI: https://doi.org/10.1038/s41434-018-0007-x

Paper Preclinical assessment of antigen-specific chimeric antigen receptor regulatory T cells for use in solid organ transplantation

Proïcs, Emma; David, Marion; Mojibian, Majid et al. · 2022 · Gene Therapy · DOI

Full title: Preclinical assessment of antigen-specific chimeric antigen receptor regulatory T cells for use in solid organ transplantation

Authors: Proïcs, Emma; David, Marion; Mojibian, Majid; Speck, Madeline; Lounnas-Mourey, Nadia; Govehovitch, Adeline; Baghdadi, Wissam; Desnouveaux, Justine; Bastian, Hervé; Freschi, Laura; Privat, Geoffrey; Pouzet, Cédric; Picerno, Pietro; Heimendinger, Pierre; Abel, Tobias; Fenard, David; Levings, Megan K.; Meyer, François G.; Dumont, Céline

Year: 2022

Venue: Gene Therapy

DOI: https://doi.org/10.1038/s41434-022-00358-x

Paper Synthetic cytokine receptors transmit biological signals using artificial ligands

Engelowski, Erika; Schneider, Artur; Franke, Manuel et al. · 2018 · Nature Communications · DOI

Full title: Synthetic cytokine receptors transmit biological signals using artificial ligands

Authors: Engelowski, Erika; Schneider, Artur; Franke, Manuel; Xu, Haifeng C.; Clemen, Ramona; Lang, Alexander; Baran, Paul; Binsch, Christian; Knebel, Birgit; Al‐Hasani, Hadi; Moll, Jens M.; Floß, Doreen M.; Lang, Philipp A.; Scheller, Jürgen

Year: 2018

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-018-04454-8

Paper Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic

Zhang, Xuqing; Luo, Mengyao; Dastagir, Shamael R. et al. · 2021 · Nature Communications · DOI

Full title: Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic

Authors: Zhang, Xuqing; Luo, Mengyao; Dastagir, Shamael R.; Nixon, Mellissa J.; Khamhoung, Annie; Schmidt, Andrea; Lee, Albert; Subbiah, Naren; McLaughlin, Douglas C.; Moore, Christopher; Gribble, Mary; Bayhi, Nicholas L; Amin, Viral; Pepi, Ryan; Pawar, Sneha; Lyford, Timothy J.; Soman, Vikram; Mellen, Jennifer; Carpenter, Christopher L.; Turka, Laurence A.; Wickham, Thomas J.; Chen, Tiffany F.

Year: 2021

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-021-22898-3

Paper Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality

Sachdeva, Mohit; Busser, Brian W.; Temburni, Sonal et al. · 2019 · Nature Communications · DOI

Full title: Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality

Authors: Sachdeva, Mohit; Busser, Brian W.; Temburni, Sonal; Jahangiri, Billal; Gautron, Anne-Sophie; Maréchal, Alan; Juillerat, Alexandre; Williams, Alan F.; Depil, Stéphane; Duchâteau, Philippe; Poirot, Laurent; Valton, Julien

Year: 2019

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-019-13088-3

Paper CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation

Otano, Itziar; Azpilikueta, Arantza; Glez‐Vaz, Javier et al. · 2021 · Nature Communications · DOI

Full title: CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation

Authors: Otano, Itziar; Azpilikueta, Arantza; Glez‐Vaz, Javier; Álvarez, Maite; Medina‐Echeverz, José; Cortés‐Domínguez, Iván; Ortíz-de-Solórzano, Carlos; Ellmark, Peter; Fritzell, Sara; Hernández‐Hoyos, Gabriela; Nelson, Michelle H.; Ochoa, María C.; Bolaños, Elixabet; Cuculescu, Doina; Jáuregui, Patricia; Sánchez‐Gregorio, Sandra; Etxeberría, Iñaki; Rodríguez-Ruiz, María E.; Sanmamed, Miguel F.; Teijeira, Álvaro; Berraondo, Pedro; Melero, Ignacio

Year: 2021

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-021-27613-w

Paper A long-acting interleukin-7, rhIL-7-hyFc, enhances CAR T cell expansion, persistence, and anti-tumor activity

Kim, Miriam; Jayasinghe, Reyka G.; Devenport, Jessica M. et al. · 2022 · Nature Communications · DOI

Full title: A long-acting interleukin-7, rhIL-7-hyFc, enhances CAR T cell expansion, persistence, and anti-tumor activity

Authors: Kim, Miriam; Jayasinghe, Reyka G.; Devenport, Jessica M.; Ritchey, Julie; Rettig, Michael P.; O’Neal, Julie; Staser, Karl; Kennerly, Krista; Carter, Alun; Gao, Feng; Lee, Byung Ha; Cooper, Matthew; DiPersio, John F.

Year: 2022

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-022-30860-0

Paper Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9

Liu, Lintao; Bi, Enguang; Ma, Xingzhe et al. · 2020 · Nature Communications · DOI

Full title: Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9

Authors: Liu, Lintao; Bi, Enguang; Ma, Xingzhe; Xiong, Wei; Qian, Jianfei; Ye, Lingqun; Pan, Su; Wang, Qiang; Xiao, Liuling; Yang, Maojie; Lu, Yong; Yi, Qing

Year: 2020

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-020-19672-2

Paper Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia

Sugita, Mayumi; Galetto, Román; Zong, Hongliang et al. · 2022 · Nature Communications · DOI

Full title: Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia

Authors: Sugita, Mayumi; Galetto, Román; Zong, Hongliang; Ewing-Crystal, Nathan; Trujillo-Alonso, Vicenta; Mencia-Trinchant, Nuria; Yip, Winnie; Filipe, Stéphanie; Lebuhotel, Céline; Gouble, Agnès; Hassane, Duane C.; Smith, Julianne; Roboz, Gail J.; Guzmán, Mónica L.

Year: 2022

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-022-29668-9

Paper DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system

Trotman‐Grant, Ashton; Mohtashami, Mahmood; Casal, Joshua de Sousa et al. · 2021 · Nature Communications · DOI

Full title: DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system

Authors: Trotman‐Grant, Ashton; Mohtashami, Mahmood; Casal, Joshua de Sousa; Martinez, Elisa C.; Lee, Dylan; Teichman, Sintia; Brauer, Patrick M.; Han, Jianxun; Anderson, Michele K.; Zúñiga‐Pflücker, Juan Carlos

Year: 2021

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-021-25245-8

Paper Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma

Cichocki, Frank; Bjordahl, Ryan; Goodridge, Jodie P. et al. · 2022 · Nature Communications · DOI

Full title: Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma

Authors: Cichocki, Frank; Bjordahl, Ryan; Goodridge, Jodie P.; Mahmood, Sajid; Gaidarova, Svetlana; Abujarour, Ramzey; Davis, Zachary; Merino, Aimee; Tuininga, Katie; Wang, Hongbo; Kumar, Akhilesh; Groff, Brian; Witty, Alec; Bonello, Greg; Huffman, Janel; Dailey, Thomas; Lee, Tom T.; Malmberg, Karl‐Johan; Walcheck, Bruce; Höpken, Uta E.; Rehm, Armin; Valamehr, Bahram; Miller, Jeffrey S.

Year: 2022

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-022-35127-2

Paper The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer

Li, Nan; Quan, Alex; Li, Dan et al. · 2023 · Nature Communications · DOI

Full title: The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer

Authors: Li, Nan; Quan, Alex; Li, Dan; Pan, Jiajia; Ren, Hua; Hoeltzel, Gerard D.; Val, Natalia de; Ashworth, Dana; Ni, Weiming; Zhou, Jing; Mackay, Sean; Hewitt, Stephen M.; Cachau, Raúl E.; Ho, Mitchell

Year: 2023

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-023-37616-4

Paper Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

Lee, Eric Hee Jun; Murad, John P.; Christian, Lea et al. · 2023 · Nature Communications · DOI

Full title: Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

Authors: Lee, Eric Hee Jun; Murad, John P.; Christian, Lea; Gibson, Jackson; Yamaguchi, Yukiko; Cullen, Cody; Gumber, Diana; Park, Anthony K.; Young, Cari A.; Monroy, Isabel; Yang, Jason; Stern, Lawrence A.; Adkins, Lauren; Dhapola, Gaurav; Gittins, Brenna; Chang, Wen-Chung; Martínez, Catalina; Woo, Yanghee; Cristea, Mihaela; Rodrı́guez-Rodrı́guez, Lorna; Ishihara, Jun; Lee, John K.; Forman, Stephen J.; Wang, Leo D.; Priceman, Saul J.

Year: 2023

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-023-40115-1

Paper Histone marks identify novel transcription factors that parse CAR-T subset-of-origin, clinical potential and expansion

S. Fiorenza; Y. Zheng; J. Purushe et al. · 2024 · Nature Communications · DOI

Full title: Histone marks identify novel transcription factors that parse CAR-T subset-of-origin, clinical potential and expansion

Authors: S. Fiorenza; Y. Zheng; J. Purushe; T. Bock; J. Sarthy; D. Janssens; A. S. Sheih; E. Kimble; D. Kirchmeier; T. Phi; J. Gauthier; A. Hirayama; S. Riddell; Q. Wu; R. Gottardo; D. G. Maloney; J. Y. H. Yang; S. Henikoff; C. Turtle

Year: 2024

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-024-52503-2

Paper Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells

Ueda, Tatsuki; Shiina, Sara; Iriguchi, Shoichi et al. · 2022 · Nature Biomedical Engineering · DOI

Full title: Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells

Authors: Ueda, Tatsuki; Shiina, Sara; Iriguchi, Shoichi; Terakura, Seitaro; Kawai, Yohei; Kabai, Ryotaro; Sakamoto, Satoko; Watanabe, Akira; Ohara, Kohei; Wang, Bo; Xu, Huaigeng; Minagawa, Atsutaka; Hotta, Akitsu; Woltjen, Knut; Uemura, Yasushi; Kodama, Yuzo; Seno, Hiroshi; Nakatsura, Tetsuya; Tamada, Koji; Kaneko, Shin

Year: 2022

Venue: Nature Biomedical Engineering

DOI: https://doi.org/10.1038/s41551-022-00969-0

Paper IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity

Landoni, Elisa; Woodcock, Mark G.; Barragán, Gabriel A. et al. · 2024 · Nature Communications · DOI

Full title: IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity

Authors: Landoni, Elisa; Woodcock, Mark G.; Barragán, Gabriel A.; Casirati, Gabriele; Cinella, Vincenzo; Stucchi, Simone; Flick, Leah M.; Withers, Tracy A.; Hudson, Hanna; Casorati, Giulia; Dellabona, Paolo; Genovese, Pietro; Savoldo, Barbara; Metelitsa, Leonid S.; Dotti, Gianpietro

Year: 2024

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-023-44310-y

Paper Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma

Gyurdieva, Alexandra; Zajic, Stefan; Chang, Ya-Fang et al. · 2022 · Nature Communications · DOI

Full title: Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma

Authors: Gyurdieva, Alexandra; Zajic, Stefan; Chang, Ya-Fang; Houseman, E. Andrés; Zhong, Shan; Kim, Jaegil; Nathenson, Michael J.; Faitg, Thomas; Woessner, Mary; Turner, David C.; Hasan, Aisha; Glod, John; Kaplan, Rosandra N.; D’Angelo, Sandra P.; Araujo, Dejka M.; Chow, Warren; Druta, Mihaela; Demetri, George D.; Tine, Brian A. Van; Grupp, Stephan A.; Fine, Gregg; Eleftheriadou, Ioanna

Year: 2022

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-022-32491-x

Paper Enhancing CAR-T cell functionality in a patient-specific manner

David K. Y. Zhang; Kwasi Adu-Berchie; Siddharth Iyer et al. · 2023 · Nature Communications · DOI

Full title: Enhancing CAR-T cell functionality in a patient-specific manner

Authors: David K. Y. Zhang; Kwasi Adu-Berchie; Siddharth Iyer; Yutong Liu; Nicoletta Cieri; Joshua M. Brockman; D. Neuberg; Catherine J. Wu; D. Mooney

Year: 2023

Venue: Nature Communications

DOI: https://doi.org/10.1038/s41467-023-36126-7

Paper Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy

Tao Zheng; Keerthana Ramanathan; Maria Ormhøj et al. · 2025 · bioRxiv · DOI

Full title: Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy

Authors: Tao Zheng; Keerthana Ramanathan; Maria Ormhøj; M. R. Hansen; H. Halldórsdóttir; Hanxi Li; K. K. Munk; C. Rodriguez-Pardo; Rasmus Ulslev Wegener Friis; Seder Fayyad Islam; P. Heegaard; Klaus Qvortrup; Hinrich Abken; Yi Sun; Sine Reker Hardup

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.04.10.648181

Paper Potentiating adoptive cell therapy using synthetic IL-9 receptors

Kalbasi, Anusha; Siurala, Mikko; Su, Leon et al. · 2022 · Nature · DOI

Full title: Potentiating adoptive cell therapy using synthetic IL-9 receptors

Authors: Kalbasi, Anusha; Siurala, Mikko; Su, Leon; Tariveranmoshabad, Mito; Picton, Lora K.; Ravikumar, Pranali; Li, Peng; Lin, Jian‐Xin; Escuin-Ordinas, Helena; Da, Tong; Kremer, Sarah; Sun, Amy; Castelli, Sofia; Agarwal, Sangya; Scholler, John; Song, Decheng; Rommel, Philipp C.; Radaelli, Enrico; Young, Regina M.; Leonard, Warren J.; Ribas, Antoni; June, Carl H.; García, K. Christopher

Year: 2022

Venue: Nature

DOI: https://doi.org/10.1038/s41586-022-04801-2

Paper GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas

Majzner, Robbie G.; Ramakrishna, Sneha; Yeom, Kristen W. et al. · 2022 · Nature · DOI

Full title: GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas

Authors: Majzner, Robbie G.; Ramakrishna, Sneha; Yeom, Kristen W.; Patel, Shabnum; Chinnasamy, Harshini; Schultz, Liora M.; Richards, Rebecca M.; Jiang, Li; Barsan, Valentin; Mancusi, Rebecca; Geraghty, Anna C.; Good, Zinaida; Mochizuki, Aaron; Gillespie, Shawn; Toland, Angus; Mahdi, Jasia; Reschke, Agnes; Nie, Esther H.; Chau, Isabelle J.; Rotiroti, Maria Caterina; Mount, Christopher; Baggott, Christina; Mavroukakis, Sharon; Egeler, Emily; Moon, Jennifer; Erickson, Courtney; Green, Sean; Kunicki, Michael; Fujimoto, Michelle; Ehlinger, Zachary; Reynolds, Warren D.; Kurra, Sreevidya; Warren, Katherine E.; Prabhu, Snehit; Vogel, Hannes; Rasmussen, Lindsey; Cornell, Timothy T.; Partap, Sonia; Fisher, Paul G.; Campen, Cynthia; Filbin, Mariella G.; Grant, Gerald A.; Sahaf, Bita; Davis, Kara L.; Feldman, Steven A.; Mackall, Crystal L.; Monje, Michelle

Year: 2022

Venue: Nature

DOI: https://doi.org/10.1038/s41586-022-04489-4

Paper A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy

Quijano‐Rubio, Alfredo; Bhuiyan, M. Aladdin; Yang, Huilin et al. · 2022 · Nature Biotechnology · DOI

Full title: A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy

Authors: Quijano‐Rubio, Alfredo; Bhuiyan, M. Aladdin; Yang, Huilin; Leung, Isabel; Bello, Elisa; Ali, Lestat R.; Zhangxu, Kevin; Perkins, Jilliane; Chun, Jung-Ho; Wang, Wentao; Lajoie, Marc J.; Ravichandran, Rashmi; Kuo, Yun‐Huai; Dougan, Stephanie K.; Riddell, Stanley R.; Spangler, Jamie B.; Dougan, Michael; Silva, Daniel‐Adriano; Baker, David

Year: 2022

Venue: Nature Biotechnology

DOI: https://doi.org/10.1038/s41587-022-01510-z

Paper Deconvolution of clinical variance in CAR-T cell pharmacology and response

Kirouac, Daniel C.; Zmurchok, Cole; Deyati, Avisek et al. · 2023 · Nature Biotechnology · DOI

Full title: Deconvolution of clinical variance in CAR-T cell pharmacology and response

Authors: Kirouac, Daniel C.; Zmurchok, Cole; Deyati, Avisek; Sicherman, Jordan; Bond, Chris T.; Zandstra, Peter W.

Year: 2023

Venue: Nature Biotechnology

DOI: https://doi.org/10.1038/s41587-023-01687-x

Paper CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial

Spiegel, Jay Y.; Patel, Shabnum; Muffly, Lori et al. · 2021 · Nature Medicine · DOI

Full title: CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial

Authors: Spiegel, Jay Y.; Patel, Shabnum; Muffly, Lori; Hossain, Nasheed; Oak, Jean; Baird, John H.; Frank, Matthew J.; Shiraz, Parveen; Sahaf, Bita; Craig, Juliana; Iglesias, María; Younes, Sheren; Natkunam, Yasodha; Ozawa, Michael G.; Yang, Eric; Tamaresis, John; Chinnasamy, Harshini; Ehlinger, Zachary; Reynolds, Warren D.; Lynn, Rachel C.; Rotiroti, Maria Caterina; Gkitsas, Nikolaos; Arai, Sally; Johnston, Laura; Lowsky, Robert; Majzner, Robbie G.; Meyer, Everett; Negrin, Robert S.; Rezvani, Andrew R.; Sidana, Surbhi; Shizuru, Judith A.; Weng, Wen‐Kai; Mullins, Chelsea; Jacob, Allison P.; Kirsch, Ilan; Bazzano, Magali; Zhou, Jing; Mackay, Sean; Bornheimer, Scott J.; Schultz, Liora M.; Ramakrishna, Sneha; Davis, Kara L.; Kong, Katherine A.; Shah, Nirali N.; Qin, Haiying; Fry, Terry J.; Feldman, Steven A.; Mackall, Crystal L.; Miklos, David B.

Year: 2021

Venue: Nature Medicine

DOI: https://doi.org/10.1038/s41591-021-01436-0

Paper Tumor immune contexture is a determinant of anti-CD19 CAR T cell efficacy in large B cell lymphoma

Scholler, Nathalie; Perbost, Régis; Locke, Frederick L. et al. · 2022 · Nature Medicine · DOI

Full title: Tumor immune contexture is a determinant of anti-CD19 CAR T cell efficacy in large B cell lymphoma

Authors: Scholler, Nathalie; Perbost, Régis; Locke, Frederick L.; Jain, Michael D.; Turcan, Sarah; Danan, Corinne; Chang, Edmund C.; Neelapu, Sattva S.; Miklos, David B.; Jacobson, Caron A.; Lekakis, Lazaros J.; Lin, Yi; Ghobadi, Armin; Kim, Jaeyeon; Chou, Justin; Plaks, Vicki; Wang, Zixing; Xue, Allen; Mattie, Mike; Rossi, John M.; Bot, Adrian; Galon, Jérôme

Year: 2022

Venue: Nature Medicine

DOI: https://doi.org/10.1038/s41591-022-01916-x

Paper Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial

Brown, Christine E.; Hibbard, Jonathan; Alizadeh, Darya et al. · 2024 · Nature Medicine · DOI

Full title: Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial

Authors: Brown, Christine E.; Hibbard, Jonathan; Alizadeh, Darya; Blanchard, M. Suzette; Natri, Heini M.; Wang, Dongrui; Ostberg, Julie R.; Aguilar, Brenda; Wagner, Jamie R.; Paul, Jinny; Starr, Renate; Wong, Robyn A.; Chen, Wuyang; Shulkin, Noah; Aftabizadeh, Maryam; Filippov, Aleksandr; Chaudhry, Ammar; Ressler, Julie A.; Kilpatrick, Julie; Myers-McNamara, Paige; Chen, Mike Y.; Wang, Leo D.; Rockne, Russell C.; Georges, Joseph; Portnow, Jana; Barish, Michael E.; D’Apuzzo, Massimo; Banovich, Nicholas E.; Forman, Stephen J.; Badie, Behnam

Year: 2024

Venue: Nature Medicine

DOI: https://doi.org/10.1038/s41591-024-02875-1

Paper CLDN6-specific CAR-T cells plus amplifying RNA vaccine in relapsed or refractory solid tumors: the phase 1 BNT211-01 trial

Mackensen, Andréas; Haanen, John B.A.G.; Koenecke, Christian et al. · 2023 · Nature Medicine · DOI

Full title: CLDN6-specific CAR-T cells plus amplifying RNA vaccine in relapsed or refractory solid tumors: the phase 1 BNT211-01 trial

Authors: Mackensen, Andréas; Haanen, John B.A.G.; Koenecke, Christian; Alsdorf, Winfried; Wagner-Drouet, Eva; Borchmann, Peter; Heudobler, Daniel; Ferstl, Barbara; Klobuch, Sebastian; Bokemeyer, Carsten; Desuki, Alexander; Lüke, Florian; Kutsch, Nadine; Müller, Fabian; Smit, Eveline; Hillemanns, Peter; Karagiannis, Panagiotis; Wiegert, Erol; He, Ying; Ho, Thang; Kang-Fortner, Qing; Schlitter, Anna Melissa; Schulz-Eying, Catrine; Finlayson, Andrew; Flemmig, Carina; Kühlcke, Klaus; Preußner, Liane; Rengstl, Benjamin; Türeci, Özlem; Şahin, Uğur

Year: 2023

Venue: Nature Medicine

DOI: https://doi.org/10.1038/s41591-023-02612-0

Paper Intracellular delivery of mRNA to human primary T cells with microfluidic vortex shedding

Jarrell, Justin A.; Twite, Amy A.; Lau, Katherine H. W. J. et al. · 2019 · Scientific Reports · DOI

Full title: Intracellular delivery of mRNA to human primary T cells with microfluidic vortex shedding

Authors: Jarrell, Justin A.; Twite, Amy A.; Lau, Katherine H. W. J.; Kashani, Moein Navvab; Lievano, Adrian A.; Acevedo, Julyana; Priest, Craig; Nieva, Jorge J.; Gottlieb, David; Pawell, Ryan S.

Year: 2019

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-019-40147-y

Paper Transgenic expression of IL-7 regulates CAR-T cell metabolism and enhances in vivo persistence against tumor cells

Li, Li; Li, Qing; Yan, Zi‐Xun et al. · 2022 · Scientific Reports · DOI

Full title: Transgenic expression of IL-7 regulates CAR-T cell metabolism and enhances in vivo persistence against tumor cells

Authors: Li, Li; Li, Qing; Yan, Zi‐Xun; Sheng, Lingshuang; Fu, Di; Xu, Pengpeng; Wang, Li; Zhao, Weili

Year: 2022

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-022-16616-2

Paper Manufacturing and preclinical validation of CAR T cells targeting ICAM-1 for advanced thyroid cancer therapy

Vedvyas, Yogindra; McCloskey, Jaclyn E.; Yang, Yanping et al. · 2019 · Scientific Reports · DOI

Full title: Manufacturing and preclinical validation of CAR T cells targeting ICAM-1 for advanced thyroid cancer therapy

Authors: Vedvyas, Yogindra; McCloskey, Jaclyn E.; Yang, Yanping; Min, Irene M.; Fahey, Thomas J.; Zarnegar, Rasa; Hsu, Yen‐Michael S.; Hsu, Jingmei; Besien, Koen van; Gaudet, Ian; Law, Ping‐Yee; Kim, Nak Joon; Hofe, Eric von; Jin, Moonsoo M.

Year: 2019

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-019-46938-7

Paper Comparison of two lab-scale protocols for enhanced mRNA-based CAR-T cell generation and functionality

Nadine von Auw; Robert Serfling; Reni Kitte et al. · 2023 · Scientific Reports · DOI

Full title: Comparison of two lab-scale protocols for enhanced mRNA-based CAR-T cell generation and functionality

Authors: Nadine von Auw; Robert Serfling; Reni Kitte; N. Hilger; Chengkang Zhang; Clara Gebhardt; Anna Duenkel; Paul Franz; U. Koehl; Stephan Fricke; U. S. Tretbar

Year: 2023

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-023-45197-x

Paper convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting

Landgraf, Kyle E.; Williams, Steven R.; Steiger, Daniel et al. · 2020 · Communications Biology · DOI

Full title: convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting

Authors: Landgraf, Kyle E.; Williams, Steven R.; Steiger, Daniel; Gebhart, Dana; Lok, Stephen; Martin, David W.; Roybal, Kole T.; Kim, Kaman Chan

Year: 2020

Venue: Communications Biology

DOI: https://doi.org/10.1038/s42003-020-1021-2

Paper Mapping real-time metabolic kinetics of expanded CAR T cells using hyperpolarized 13C-glucose and metabolomics

Thomas B. Wareham Mathiassen; M. R. Hansen; Magnus Karlsson et al. · 2025 · Scientific Reports · DOI

Full title: Mapping real-time metabolic kinetics of expanded CAR T cells using hyperpolarized 13C-glucose and metabolomics

Authors: Thomas B. Wareham Mathiassen; M. R. Hansen; Magnus Karlsson; S. Hadrup; Maria Ormhøj; P. R. Jensen

Year: 2025

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-025-24712-2

Paper In vitro encapsulation and expansion of T and CAR-T cells using 3D synthetic thermo-responsive matrices

Gaby D Lizana-Vasquez; Janet Mendez-Vega; D. Cappabianca et al. · 2024 · RSC Advances · DOI

Full title: In vitro encapsulation and expansion of T and CAR-T cells using 3D synthetic thermo-responsive matrices

Authors: Gaby D Lizana-Vasquez; Janet Mendez-Vega; D. Cappabianca; Krishanu Saha; M. Torres-Lugo

Year: 2024

Venue: RSC Advances

DOI: https://doi.org/10.1039/d4ra01968g

Paper Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response

Gnanaprakasam, JN Rashida; Kushwaha, Bhavana; Liu, Lingling et al. · 2023 · Nature Metabolism · DOI

Full title: Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response

Authors: Gnanaprakasam, JN Rashida; Kushwaha, Bhavana; Liu, Lingling; Chen, Xuyong; Kang, Siwen; Wang, Tingting; Cassel, Teresa; Adams, Christopher M.; Higashi, Richard M.; Scott, David A.; Xin, Gang; Li, Zihai; Yang, Jun J.; Lane, Andrew N.; Fan, Teresa W.‐M.; Zhang, Ji; Wang, Ruoning

Year: 2023

Venue: Nature Metabolism

DOI: https://doi.org/10.1038/s42255-023-00856-1

Paper Enhanced functionality of low-affinity CD19 CAR T-cells is associated with activation priming and a polyfunctional cytokine phenotype

I. Michelozzi; Eduardo Gómez Castañeda; R. V. Pohle et al. · 2020 · bioRxiv · DOI

Full title: Enhanced functionality of low-affinity CD19 CAR T-cells is associated with activation priming and a polyfunctional cytokine phenotype

Authors: I. Michelozzi; Eduardo Gómez Castañeda; R. V. Pohle; Ferran Cardoso Rodriguez; J. Sufi; Pau Puigdevall Costa; Meera Subramaniyam; Efstratios Kirtsios; A. Eddaoudi; S. Wu; A. Guvenel; J. Fisher; S. Ghorashian; M. Pule; C. Tape; S. Castellano; P. Amrolia; Alice Giustacchini

Year: 2020

Venue: bioRxiv

DOI: https://doi.org/10.1101/2020.09.22.291831

Paper CD62L-selected umbilical cord blood universal CAR T cells

C. Georgiadis; Lauren E Nickolay; Farhatullah Syed et al. · 2024 · bioRxiv · DOI

Full title: CD62L-selected umbilical cord blood universal CAR T cells

Authors: C. Georgiadis; Lauren E Nickolay; Farhatullah Syed; H. Zhan; S. A. Gkazi; Annie Etuk; Ulrike Abramowski-Mock; Roland Preece; Piotr Cuber; Stuart Adams; G. Ottaviano; W. Qasim

Year: 2024

Venue: bioRxiv

DOI: https://doi.org/10.1101/2024.01.18.576145

Paper Potentiation of Natural Killer Cells for Cancer Immunotherapy: A Review of Literature

Lowry, Lacy E.; Zehring, William A. · 2017 · Frontiers in Immunology · DOI

Full title: Potentiation of Natural Killer Cells for Cancer Immunotherapy: A Review of Literature

Authors: Lowry, Lacy E.; Zehring, William A.

Year: 2017

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2017.01061

Paper Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells

Dawson, Nicholas A.J.; Vent‐Schmidt, Jens; Levings, Megan K. · 2017 · Frontiers in Immunology · DOI

Full title: Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells

Authors: Dawson, Nicholas A.J.; Vent‐Schmidt, Jens; Levings, Megan K.

Year: 2017

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2017.01460

Paper Chimeric Antigen Receptor Expressing Natural Killer Cells for the Immunotherapy of Cancer

Mehta, Rohtesh S.; Rezvani, Katayoun · 2018 · Frontiers in Immunology · DOI

Full title: Chimeric Antigen Receptor Expressing Natural Killer Cells for the Immunotherapy of Cancer

Authors: Mehta, Rohtesh S.; Rezvani, Katayoun

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.00283

Paper Immunotherapy for Dogs: Running Behind Humans

Klingemann, Hans · 2018 · Frontiers in Immunology · DOI

Full title: Immunotherapy for Dogs: Running Behind Humans

Authors: Klingemann, Hans

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.00133

Paper Cytokine-Induced Killer Cells As Pharmacological Tools for Cancer Immunotherapy

Gao, Xingchun; Mi, Yajing; Guo, Na et al. · 2017 · Frontiers in Immunology · DOI

Full title: Cytokine-Induced Killer Cells As Pharmacological Tools for Cancer Immunotherapy

Authors: Gao, Xingchun; Mi, Yajing; Guo, Na; Xu, Hao; Xu, Lixian; Gou, Xingchun; Jin, Weilin

Year: 2017

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2017.00774

Paper Clinical Grade Regulatory CD4+ T Cells (Tregs): Moving Toward Cellular-Based Immunomodulatory Therapies

Duggleby, Richard; Danby, Robert; Madrigal, J. Alejandro et al. · 2018 · Frontiers in Immunology · DOI

Full title: Clinical Grade Regulatory CD4+ T Cells (Tregs): Moving Toward Cellular-Based Immunomodulatory Therapies

Authors: Duggleby, Richard; Danby, Robert; Madrigal, J. Alejandro; Saudemont, Aurore

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.00252

Paper Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local

Pauza, C. David; Liou, Mei-Ling; Lahusen, Tyler et al. · 2018 · Frontiers in Immunology · DOI

Full title: Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local

Authors: Pauza, C. David; Liou, Mei-Ling; Lahusen, Tyler; Xiao, Lingzhi; Lapidus, Rena G.; Cairo, Cristiana; Li, Haishan

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.01305

Paper Immunological Approaches Towards Cancer and Inflammation: A Cross Talk

Qu, Xinglong; Tang, Ying; Hua, Shucheng · 2018 · Frontiers in Immunology · DOI

Full title: Immunological Approaches Towards Cancer and Inflammation: A Cross Talk

Authors: Qu, Xinglong; Tang, Ying; Hua, Shucheng

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.00563

Paper Extracellular NGFR Spacers Allow Efficient Tracking and Enrichment of Fully Functional CAR-T Cells Co-Expressing a Suicide Gene

M. Casucci; Laura Falcone; B. Camisa et al. · 2018 · Frontiers in Immunology · DOI

Full title: Extracellular NGFR Spacers Allow Efficient Tracking and Enrichment of Fully Functional CAR-T Cells Co-Expressing a Suicide Gene

Authors: M. Casucci; Laura Falcone; B. Camisa; M. Norelli; S. Porcellini; A. Stornaiuolo; F. Ciceri; C. Traversari; C. Bordignon; C. Bonini; A. Bondanza

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.00507

Paper GMP-Grade Manufacturing of T Cells Engineered to Express a Defined γδTCR

T. Straetemans; G. Kierkels; Ruud Doorn et al. · 2018 · Frontiers in Immunology · DOI

Full title: GMP-Grade Manufacturing of T Cells Engineered to Express a Defined γδTCR

Authors: T. Straetemans; G. Kierkels; Ruud Doorn; Koen Jansen; Sabine Heijhuurs; J. M. dos Santos; Anna D. D. van Muyden; H. Vié; B. Clémenceau; R. Raymakers; M. D. de Witte; Z. Sebestyén; J. Kuball

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.01062

Paper Immune Cell Hacking: Challenges and Clinical Approaches to Create Smarter Generations of Chimeric Antigen Receptor T Cells

Elahi, Reza; Khosh, Elnaz; Tahmasebi, Safa et al. · 2018 · Frontiers in Immunology · DOI

Full title: Immune Cell Hacking: Challenges and Clinical Approaches to Create Smarter Generations of Chimeric Antigen Receptor T Cells

Authors: Elahi, Reza; Khosh, Elnaz; Tahmasebi, Safa; Esmaeilzadeh, Abdolreza

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.01717

Paper Perspectives on Chimeric Antigen Receptor T-Cell Immunotherapy for Solid Tumors

Kosti, Paris; Maher, John; Arnold, James N. · 2018 · Frontiers in Immunology · DOI

Full title: Perspectives on Chimeric Antigen Receptor T-Cell Immunotherapy for Solid Tumors

Authors: Kosti, Paris; Maher, John; Arnold, James N.

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.01104

Paper CAR T Cell Therapy for Neuroblastoma

Richards, Rebecca M.; Sotillo, Elena; Majzner, Robbie G. · 2018 · Frontiers in Immunology · DOI

Full title: CAR T Cell Therapy for Neuroblastoma

Authors: Richards, Rebecca M.; Sotillo, Elena; Majzner, Robbie G.

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.02380

Paper Inflammatory Cytokines Regulate T-Cell Development from Blood Progenitor Cells in a Stage and Dose-Specifc Manner

John M. Edgar; P. Zandstra · 2021 · bioRxiv · DOI

Full title: Inflammatory Cytokines Regulate T-Cell Development from Blood Progenitor Cells in a Stage and Dose-Specifc Manner

Authors: John M. Edgar; P. Zandstra

Year: 2021

Venue: bioRxiv

DOI: https://doi.org/10.1101/2021.01.18.427186

Paper The Potential of CAR T Cell Therapy in Pancreatic Cancer

Akce, Mehmet; Zaidi, Mohammad Y.; Waller, Edmund K. et al. · 2018 · Frontiers in Immunology · DOI

Full title: The Potential of CAR T Cell Therapy in Pancreatic Cancer

Authors: Akce, Mehmet; Zaidi, Mohammad Y.; Waller, Edmund K.; El‐Rayes, Bassel F.; Lesinski, Gregory B.

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.02166

Paper CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies

Knochelmann, Hannah M.; Smith, Aubrey S.; Dwyer, Connor J. et al. · 2018 · Frontiers in Immunology · DOI

Full title: CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies

Authors: Knochelmann, Hannah M.; Smith, Aubrey S.; Dwyer, Connor J.; Wyatt, Megan M.; Mehrotra, Shikhar; Paulos, Chrystal M.

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.01740

Paper Lymphocytes in Cellular Therapy: Functional Regulation of CAR T Cells

Dwivedi, Alka; Karulkar, Atharva; Ghosh, Sarbari et al. · 2019 · Frontiers in Immunology · DOI

Full title: Lymphocytes in Cellular Therapy: Functional Regulation of CAR T Cells

Authors: Dwivedi, Alka; Karulkar, Atharva; Ghosh, Sarbari; Rafiq, Afrin; Purwar, Rahul

Year: 2019

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.03180

Paper Engineering CAR-T Cells for Improved Function Against Solid Tumors

Morgan, Michael; Schambach, Axel · 2018 · Frontiers in Immunology · DOI

Full title: Engineering CAR-T Cells for Improved Function Against Solid Tumors

Authors: Morgan, Michael; Schambach, Axel

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.02493

Paper Therapeutic Potential of Natural Killer Cells in Gastric Cancer

Du, Yu; Wei, Yongchang · 2019 · Frontiers in Immunology · DOI

Full title: Therapeutic Potential of Natural Killer Cells in Gastric Cancer

Authors: Du, Yu; Wei, Yongchang

Year: 2019

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.03095

Paper HLA-Class II Artificial Antigen Presenting Cells in CD4+ T Cell-Based Immunotherapy

Couture, Alexandre; Garnier, Anthony; Docagne, Fabián et al. · 2019 · Frontiers in Immunology · DOI

Full title: HLA-Class II Artificial Antigen Presenting Cells in CD4+ T Cell-Based Immunotherapy

Authors: Couture, Alexandre; Garnier, Anthony; Docagne, Fabián; Boyer, Olivier; Vivien, Denis; LEMAUFF, BRIGITTE; Latouche, Jean‐Baptiste; Toutirais, Olivier

Year: 2019

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2019.01081

Paper Cancer Immunotherapy Based on Natural Killer Cells: Current Progress and New Opportunities

Hu, Weilei; Wang, Guosheng; Huang, Dongsheng et al. · 2019 · Frontiers in Immunology · DOI

Full title: Cancer Immunotherapy Based on Natural Killer Cells: Current Progress and New Opportunities

Authors: Hu, Weilei; Wang, Guosheng; Huang, Dongsheng; Sui, Meihua; Xu, Yibing

Year: 2019

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2019.01205

Paper Automated Clinical Grade Expansion of Regulatory T Cells in a Fully Closed System

José Manuel Marín Morales; Nadine Münch; K. Peter et al. · 2019 · Frontiers in Immunology · DOI

Full title: Automated Clinical Grade Expansion of Regulatory T Cells in a Fully Closed System

Authors: José Manuel Marín Morales; Nadine Münch; K. Peter; D. Freund; U. Oelschlägel; K. Hölig; T. Böhm; A. Flach; J. Kessler; E. Bonifacio; M. Bornhäuser; A. Fuchs

Year: 2019

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2019.00038

Paper Cold Tumors: A Therapeutic Challenge for Immunotherapy

Bonaventura, Paola; Shekarian, Tala; Alcazer, Vincent et al. · 2019 · Frontiers in Immunology · DOI

Full title: Cold Tumors: A Therapeutic Challenge for Immunotherapy

Authors: Bonaventura, Paola; Shekarian, Tala; Alcazer, Vincent; Valladeau‐Guilemond, Jenny; Valsesia‐Wittmann, Sandrine; Amigorena, Sebastián; Caux, Christophe; Depil, Stéphane

Year: 2019

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2019.00168

Paper Genetic Modification Strategies to Enhance CAR T Cell Persistence for Patients With Solid Tumors

DeRenzo, Christopher; Gottschalk, Stephen · 2019 · Frontiers in Immunology · DOI

Full title: Genetic Modification Strategies to Enhance CAR T Cell Persistence for Patients With Solid Tumors

Authors: DeRenzo, Christopher; Gottschalk, Stephen

Year: 2019

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2019.00218

Paper L-Selectin Enhanced T Cells Improve the Efficacy of Cancer Immunotherapy

Watson, H. Angharad; Durairaj, Ruban Rex Peter; Ohme, Julia et al. · 2019 · Frontiers in Immunology · DOI

Full title: L-Selectin Enhanced T Cells Improve the Efficacy of Cancer Immunotherapy

Authors: Watson, H. Angharad; Durairaj, Ruban Rex Peter; Ohme, Julia; Alatsatianos, Markella; Almutairi, Hanan; Mohammed, Rebar N.; Vigar, Miriam Ann; Reed, Sophie; Paisey, Stephen J.; Marshall, Christopher; Gallimore, Awen; Ager, Ann

Year: 2019

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2019.01321

Paper Engineered T Cell Therapy for Cancer in the Clinic

Zhao, Lijun; Cao, Yu · 2019 · Frontiers in Immunology · DOI

Full title: Engineered T Cell Therapy for Cancer in the Clinic

Authors: Zhao, Lijun; Cao, Yu

Year: 2019

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2019.02250

Paper The Synergistic Use of IL-15 and IL-21 for the Generation of NK Cells From CD3/CD19-Depleted Grafts Improves Their ex vivo Expansion and Cytotoxic Potential Against Neuroblastoma: Perspective for Optimized Immunotherapy Post Haploidentical Stem Cell Transplantation

Heinze, Annekathrin; Grebe, Beatrice; Bremm, Melanie et al. · 2019 · Frontiers in Immunology · DOI

Full title: The Synergistic Use of IL-15 and IL-21 for the Generation of NK Cells From CD3/CD19-Depleted Grafts Improves Their ex vivo Expansion and Cytotoxic Potential Against Neuroblastoma: Perspective for Optimized Immunotherapy Post Haploidentical Stem Cell Transplantation

Authors: Heinze, Annekathrin; Grebe, Beatrice; Bremm, Melanie; Huenecke, Sabine; Munir, Tasleem Ah.; Graafen, Lea; Frueh, Jochen T.; Merker, Matthias; Rettinger, Eva; Soerensen, Jan; Klingebiel, Thomas; Bader, Peter; Ullrich, Evelyn; Cappel, Claudia

Year: 2019

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2019.02816

Paper Targeting Natural Killer Cells for Tumor Immunotherapy

Zhang, Cai; Hu, Yuan; Shi, Chongdeng · 2020 · Frontiers in Immunology · DOI

Full title: Targeting Natural Killer Cells for Tumor Immunotherapy

Authors: Zhang, Cai; Hu, Yuan; Shi, Chongdeng

Year: 2020

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2020.00060

Paper Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector

Colamartino, A.; Lemieux, William; Bifsha, Panojot et al. · 2019 · Frontiers in Immunology · DOI

Full title: Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector

Authors: Colamartino, A.; Lemieux, William; Bifsha, Panojot; Nicoletti, Simon; Chakravarti, Nitin; Sanz, Joaquín; Romero, Hugo Grisales; Selleri, Silvia; Béland, Kathie; Guiot, Mélanie; Tremblay‐Laganière, Camille; Dicaire, Renée; Barreiro, Luis B.; Lee, Dean A.; Verhoeyen, Els; Haddad, Élie

Year: 2019

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2019.02873

Paper Universal Ready-to-Use Immunotherapeutic Approach for the Treatment of Cancer: Expanded and Activated Polyclonal γδ Memory T Cells

V. A. Polito; R. Cristantielli; G. Weber et al. · 2019 · Frontiers in Immunology · DOI

Full title: Universal Ready-to-Use Immunotherapeutic Approach for the Treatment of Cancer: Expanded and Activated Polyclonal γδ Memory T Cells

Authors: V. A. Polito; R. Cristantielli; G. Weber; F. del Bufalo; Tamascia Belardinilli; C. Arnone; A. Petretto; L. Antonucci; E. Giorda; N. Tumino; A. Pitisci; B. De Angelis; C. Quintarelli; F. Locatelli; Ignazio Caruana

Year: 2019

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2019.02717

Paper Exploiting Human NK Cells in Tumor Therapy

Vacca, Paola; Pietra, Gabriella; Tumino, Nicola et al. · 2020 · Frontiers in Immunology · DOI

Full title: Exploiting Human NK Cells in Tumor Therapy

Authors: Vacca, Paola; Pietra, Gabriella; Tumino, Nicola; Munari, Enrico; Mingari, Maria Cristina; Moretta, Lorenzo

Year: 2020

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2019.03013

Paper Overcoming Chimeric Antigen Receptor (CAR) Modified T-Cell Therapy Limitations in Multiple Myeloma

García‐Guerrero, Estefanía; Sierro-Martínez, Belén; Pérez-Simón, Josè Antonio · 2020 · Frontiers in Immunology · DOI

Full title: Overcoming Chimeric Antigen Receptor (CAR) Modified T-Cell Therapy Limitations in Multiple Myeloma

Authors: García‐Guerrero, Estefanía; Sierro-Martínez, Belén; Pérez-Simón, Josè Antonio

Year: 2020

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2020.01128

Paper Next-Generation Manufacturing Protocols Enriching TSCM CAR T Cells Can Overcome Disease-Specific T Cell Defects in Cancer Patients.

Arcangeli, Silvia; Falcone, Laura; Camisa, Barbara et al. · 2020 · Frontiers in immunology · DOI

Full title: Next-Generation Manufacturing Protocols Enriching TSCM CAR T Cells Can Overcome Disease-Specific T Cell Defects in Cancer Patients.

Authors: Arcangeli, Silvia; Falcone, Laura; Camisa, Barbara; De Girardi, Federica; Biondi, Marta; Giglio, Fabio; Ciceri, Fabio; Bonini, Chiara; Bondanza, Attilio; Casucci, Monica

Year: 2020

Venue: Frontiers in immunology

DOI: https://doi.org/10.3389/fimmu.2020.01217

Paper Point-Of-Care CAR T-Cell Production (ARI-0001) Using a Closed Semi-automatic Bioreactor: Experience From an Academic Phase I Clinical Trial

M. Castellà; M. Caballero-Baños; V. Ortiz-Maldonado et al. · 2020 · Frontiers in Immunology · DOI

Full title: Point-Of-Care CAR T-Cell Production (ARI-0001) Using a Closed Semi-automatic Bioreactor: Experience From an Academic Phase I Clinical Trial

Authors: M. Castellà; M. Caballero-Baños; V. Ortiz-Maldonado; E. A. González-Navarro; Guillermo Suñé; Asier Antoñana-Vidósola; A. Boronat; B. Marzal; Lucía Millán; B. Martín-Antonio; J. Cid; M. Lozano; Enric García; J. Tabera; E. Trias; Unai Perpiña; J. M. Canals; T. Baumann; D. Benítez-Ribas; E. Campo; J. Yagüe; Á. Urbano-Ispizua; S. Rives; J. Delgado; M. Juan

Year: 2020

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2020.00482

Paper Gamma-Delta CAR-T Cells Show CAR-Directed and Independent Activity Against Leukemia

Meir Rozenbaum; Amilia Meir; Yarden Aharony et al. · 2020 · Frontiers in Immunology · DOI

Full title: Gamma-Delta CAR-T Cells Show CAR-Directed and Independent Activity Against Leukemia

Authors: Meir Rozenbaum; Amilia Meir; Yarden Aharony; O. Itzhaki; J. Schachter; I. Bank; E. Jacoby; M. Besser

Year: 2020

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2020.01347

Paper The Next Frontier of Regulatory T Cells: Promising Immunotherapy for Autoimmune Diseases and Organ Transplantations

Terry, Lauren V.; Oo, Ye Htun · 2020 · Frontiers in Immunology · DOI

Full title: The Next Frontier of Regulatory T Cells: Promising Immunotherapy for Autoimmune Diseases and Organ Transplantations

Authors: Terry, Lauren V.; Oo, Ye Htun

Year: 2020

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2020.565518

Paper Automated Manufacture of Autologous CD19 CAR-T Cells for Treatment of Non-hodgkin Lymphoma

Zachary Jackson; A. Roe; A. Sharma et al. · 2020 · Frontiers in Immunology · DOI

Full title: Automated Manufacture of Autologous CD19 CAR-T Cells for Treatment of Non-hodgkin Lymphoma

Authors: Zachary Jackson; A. Roe; A. Sharma; Filipa B. Lopes; A. Talla; S. Kleinsorge-Block; K. Zamborsky; J. Schiavone; Shivaprasad Manjappa; Robert Schauner; Grace Lee; Ruifu Liu; P. Caimi; Y. Xiong; W. Krueger; A. Worden; M. Kadan; D. Schneider; R. Orentas; B. Dropulić; R. Sékaly; M. de Lima; D. Wald; J. Reese

Year: 2020

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2020.01941

Paper Umbilical cord blood: an expandable resource.

M. A. Moore · 2000 · Journal of Clinical Investigation · DOI

Full title: Umbilical cord blood: an expandable resource.

Authors: M. A. Moore

Year: 2000

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci9094

Paper The Future of Regulatory T Cell Therapy: Promises and Challenges of Implementing CAR Technology

Mohseni, Yasmin R.; Tung, Sim L.; Dudreuilh, Caroline et al. · 2020 · Frontiers in Immunology · DOI

Full title: The Future of Regulatory T Cell Therapy: Promises and Challenges of Implementing CAR Technology

Authors: Mohseni, Yasmin R.; Tung, Sim L.; Dudreuilh, Caroline; Lechler, Robert I.; Fruhwirth, Gilbert O.; Lombardi, Giovanna

Year: 2020

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2020.01608

Paper Plasticity in Pro- and Anti-tumor Activity of Neutrophils: Shifting the Balance

Furumaya, Charita; Martínez-Sanz, Paula; Bouti, Panagiota et al. · 2020 · Frontiers in Immunology · DOI

Full title: Plasticity in Pro- and Anti-tumor Activity of Neutrophils: Shifting the Balance

Authors: Furumaya, Charita; Martínez-Sanz, Paula; Bouti, Panagiota; Kuijpers, Taco W.; Matlung, Hanke L.

Year: 2020

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2020.02100

Paper The BCMA-Targeted Fourth-Generation CAR-T Cells Secreting IL-7 and CCL19 for Therapy of Refractory/Recurrent Multiple Myeloma

Duan, Deming; Wang, Keke; Cheng, Wei et al. · 2021 · Frontiers in Immunology · DOI

Full title: The BCMA-Targeted Fourth-Generation CAR-T Cells Secreting IL-7 and CCL19 for Therapy of Refractory/Recurrent Multiple Myeloma

Authors: Duan, Deming; Wang, Keke; Cheng, Wei; Feng, Defei; Liu, Yonghua; He, Qingyan; Xu, Xing; Wang, Chunling; Zhao, Shuping; Lv, Leili; Long, Jing; Lin, Danni; Zhao, Ai; Fang, Bingmu; Jiang, Jinhong; Tang, Shixing; Gao, Jimin

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.609421

Paper Cord-Blood Natural Killer Cell-Based Immunotherapy for Cancer

Zhao, Xiaoyan; Cai, Li; Hu, Yu et al. · 2020 · Frontiers in Immunology · DOI

Full title: Cord-Blood Natural Killer Cell-Based Immunotherapy for Cancer

Authors: Zhao, Xiaoyan; Cai, Li; Hu, Yu; Wang, Huafang

Year: 2020

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2020.584099

Paper Glioblastoma Immune Landscape and the Potential of New Immunotherapies

Daubon, Thomas; Hémadou, Audrey; Romero‐Garmendia, Irati et al. · 2020 · Frontiers in Immunology · DOI

Full title: Glioblastoma Immune Landscape and the Potential of New Immunotherapies

Authors: Daubon, Thomas; Hémadou, Audrey; Romero‐Garmendia, Irati; Saleh, Maya

Year: 2020

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2020.585616

Paper HLA Class I Knockout Converts Allogeneic Primary NK Cells Into Suitable Effectors for “Off-the-Shelf” Immunotherapy

Hoerster, Keven; Uhrberg, Markus; Wiek, Constanze et al. · 2021 · Frontiers in Immunology · DOI

Full title: HLA Class I Knockout Converts Allogeneic Primary NK Cells Into Suitable Effectors for “Off-the-Shelf” Immunotherapy

Authors: Hoerster, Keven; Uhrberg, Markus; Wiek, Constanze; Horn, Peter A.; Hanenberg, Helmut; Heinrichs, Stefan

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2020.586168

Paper Transcription Factors Associated With IL-15 Cytokine Signaling During NK Cell Development

Wang, Xiang; Zhao, Xiaosu · 2021 · Frontiers in Immunology · DOI

Full title: Transcription Factors Associated With IL-15 Cytokine Signaling During NK Cell Development

Authors: Wang, Xiang; Zhao, Xiaosu

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.610789

Paper GMP-Compliant Universal Antigen Presenting Cells (uAPC) Promote the Metabolic Fitness and Antitumor Activity of Armored Cord Blood CAR-NK Cells

Liu, Enli; Ang, Sonny; Kerbauy, Lucila Nassif et al. · 2021 · Frontiers in Immunology · DOI

Full title: GMP-Compliant Universal Antigen Presenting Cells (uAPC) Promote the Metabolic Fitness and Antitumor Activity of Armored Cord Blood CAR-NK Cells

Authors: Liu, Enli; Ang, Sonny; Kerbauy, Lucila Nassif; Başar, Rafet; Kaur, Indreshpal; Kaplan, Mecit; Li, Li; Tong, Yijiu; Daher, May; Ensley, Emily L.; Uprety, Nadima; Cortes, Ana Karen Nunez; Yang, Ryan Z.; Li, Ye; Shaim, Hila; Silva, Francia Reyes; Lin, Paul; Mohanty, Vakul; Acharya, Sunil; Shanley, Mayra; Muniz-Feliciano, Luis; Banerjee, Pinaki P.; Chen, Ken; Champlin, Richard E.; Shpall, Elizabeth J.; Rezvani, Katayoun

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.626098

Paper Tr1 Cells as a Key Regulator for Maintaining Immune Homeostasis in Transplantation

Song, Yun; Wang, Ning; Chen, Lihua et al. · 2021 · Frontiers in Immunology · DOI

Full title: Tr1 Cells as a Key Regulator for Maintaining Immune Homeostasis in Transplantation

Authors: Song, Yun; Wang, Ning; Chen, Lihua; Fang, Liang

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.671579

Paper Shaping Immune Responses in the Tumor Microenvironment of Ovarian Cancer

Luo, Xin; Xu, Jing; Yu, Jianhua et al. · 2021 · Frontiers in Immunology · DOI

Full title: Shaping Immune Responses in the Tumor Microenvironment of Ovarian Cancer

Authors: Luo, Xin; Xu, Jing; Yu, Jianhua; Yi, Ping

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.692360

Paper Regulatory T Cells in GVHD Therapy

Guo, Wenwen; Su, Xiuhua; Wang, Mingyang et al. · 2021 · Frontiers in Immunology · DOI

Full title: Regulatory T Cells in GVHD Therapy

Authors: Guo, Wenwen; Su, Xiuhua; Wang, Mingyang; Han, Mingzhe; Feng, Xiaoming; Jiang, Erlie

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.697854

Paper Current Perspectives on “Off-The-Shelf” Allogeneic NK and CAR-NK Cell Therapies

Heipertz, Erica L.; Zynda, Evan R.; Stav-Noraas, Tor Espen et al. · 2021 · Frontiers in Immunology · DOI

Full title: Current Perspectives on “Off-The-Shelf” Allogeneic NK and CAR-NK Cell Therapies

Authors: Heipertz, Erica L.; Zynda, Evan R.; Stav-Noraas, Tor Espen; Hungler, Andrew D.; Boucher, Shayne; Kaur, Navjot; Vemuri, Mohan C.

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.732135

Paper Engineered Cytokine Signaling to Improve CAR T Cell Effector Function

Bell, Matthew; Gottschalk, Stephen · 2021 · Frontiers in Immunology · DOI

Full title: Engineered Cytokine Signaling to Improve CAR T Cell Effector Function

Authors: Bell, Matthew; Gottschalk, Stephen

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.684642

Paper Advances in Adoptive Cell Therapy Using Induced Pluripotent Stem Cell-Derived T Cells

Ratchapong Netsrithong; Methichit Wattanapanitch · 2021 · Frontiers in Immunology · DOI

Full title: Advances in Adoptive Cell Therapy Using Induced Pluripotent Stem Cell-Derived T Cells

Authors: Ratchapong Netsrithong; Methichit Wattanapanitch

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.759558

Paper Chimeric Antigen Receptor T-Cell Therapy in Lung Cancer: Potential and Challenges

Xiao, Bufan; Zhang, Jingtao; Zhu, Yuge et al. · 2021 · Frontiers in Immunology · DOI

Full title: Chimeric Antigen Receptor T-Cell Therapy in Lung Cancer: Potential and Challenges

Authors: Xiao, Bufan; Zhang, Jingtao; Zhu, Yuge; Cui, Xinrun; Lu, Zheming; Yu, Bentong; Wu, Nan

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.782775

Paper Gene-Edited Interleukin CAR-T Cells Therapy in the Treatment of Malignancies: Present and Future

Zhang, Zhengchao; Miao, Lele; Ren, Zhijian et al. · 2021 · Frontiers in Immunology · DOI

Full title: Gene-Edited Interleukin CAR-T Cells Therapy in the Treatment of Malignancies: Present and Future

Authors: Zhang, Zhengchao; Miao, Lele; Ren, Zhijian; Tang, Futian; Li, Yumin

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.718686

Paper PiggyBac Transposon-Mediated CD19 Chimeric Antigen Receptor-T Cells Derived From CD45RA-Positive Peripheral Blood Mononuclear Cells Possess Potent and Sustained Antileukemic Function

M. Suematsu; S. Yagyu; Nobuyoshi Nagao et al. · 2022 · Frontiers in Immunology · DOI

Full title: PiggyBac Transposon-Mediated CD19 Chimeric Antigen Receptor-T Cells Derived From CD45RA-Positive Peripheral Blood Mononuclear Cells Possess Potent and Sustained Antileukemic Function

Authors: M. Suematsu; S. Yagyu; Nobuyoshi Nagao; Susumu Kubota; Y. Shimizu; Miyuki Tanaka; Y. Nakazawa; T. Imamura

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.770132

Paper CXCR6 expressing T cells: Functions and role in the control of tumors

Mabrouk, Nesrine; Tran, Thi; Sam, Ikuan et al. · 2022 · Frontiers in Immunology · DOI

Full title: CXCR6 expressing T cells: Functions and role in the control of tumors

Authors: Mabrouk, Nesrine; Tran, Thi; Sam, Ikuan; Pourmir, Ivan; Gruel, Nadège; Granier, Clémence; Pineau, Joséphine; Gey, Alain; Kobold, Sebastian; Fabre, Elizabeth; Tartour, Éric

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.1022136

Paper Taking Lessons from CAR-T Cells and Going Beyond: Tailoring Design and Signaling for CAR-NK Cells in Cancer Therapy

K. Ruppel; S. Fricke; U. Köhl et al. · 2022 · Frontiers in Immunology · DOI

Full title: Taking Lessons from CAR-T Cells and Going Beyond: Tailoring Design and Signaling for CAR-NK Cells in Cancer Therapy

Authors: K. Ruppel; S. Fricke; U. Köhl; Dominik Schmiedel

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.822298

Paper Feeder Cells at the Interface of Natural Killer Cell Activation, Expansion and Gene Editing

Gurney, Mark E.; Kundu, Soumyadipta; Pandey, Shubham et al. · 2022 · Frontiers in Immunology · DOI

Full title: Feeder Cells at the Interface of Natural Killer Cell Activation, Expansion and Gene Editing

Authors: Gurney, Mark E.; Kundu, Soumyadipta; Pandey, Shubham; O’Dwyer, Michael

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.802906

Paper GMP-Compliant Manufacturing of TRUCKs: CAR T Cells targeting GD2 and Releasing Inducible IL-18

W. Glienke; A. Dragon; Katharina Zimmermann et al. · 2022 · Frontiers in Immunology · DOI

Full title: GMP-Compliant Manufacturing of TRUCKs: CAR T Cells targeting GD2 and Releasing Inducible IL-18

Authors: W. Glienke; A. Dragon; Katharina Zimmermann; A. Martyniszyn-Eiben; Mira Mertens; H. Abken; C. Rossig; B. Altvater; K. Aleksandrova; L. Arseniev; Christina Kloth; Andriana Stamopoulou; T. Moritz; H. Lode; N. Siebert; R. Blasczyk; L. Goudeva; A. Schambach; U. Köhl; B. Eiz-Vesper; R. Esser

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.839783

Paper Innovative Strategies to Improve the Clinical Application of NK Cell-Based Immunotherapy

Tarannum, Mubin; Romee, Rizwan; Shapiro, Roman M. · 2022 · Frontiers in Immunology · DOI

Full title: Innovative Strategies to Improve the Clinical Application of NK Cell-Based Immunotherapy

Authors: Tarannum, Mubin; Romee, Rizwan; Shapiro, Roman M.

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.859177

Paper Anti-PD-1 Therapy Enhances the Efficacy of CD30-Directed Chimeric Antigen Receptor T Cell Therapy in Patients With Relapsed/Refractory CD30+ Lymphoma

Sang, Wei; Wang, Xiangmin; Geng, Hongzhi et al. · 2022 · Frontiers in Immunology · DOI

Full title: Anti-PD-1 Therapy Enhances the Efficacy of CD30-Directed Chimeric Antigen Receptor T Cell Therapy in Patients With Relapsed/Refractory CD30+ Lymphoma

Authors: Sang, Wei; Wang, Xiangmin; Geng, Hongzhi; Li, Tianci; Li, Dashan; Zhang, Bingpei; Zhou, Yi; Song, Xuguang; Sun, Cai; Yan, Dongmei; Li, Depeng; Li, Zhenyu; Li, Caixia; Xu, Kailin

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.858021

Paper Manufacture of Clinical-Grade CD19-Specific T Cells Stably Expressing Chimeric Antigen Receptor Using Sleeping Beauty System and Artificial Antigen Presenting Cells

Singh, Harjeet; Figliola, Matthew J.; Dawson, Margaret J. et al. · 2013 · PLoS ONE · DOI

Full title: Manufacture of Clinical-Grade CD19-Specific T Cells Stably Expressing Chimeric Antigen Receptor Using Sleeping Beauty System and Artificial Antigen Presenting Cells

Authors: Singh, Harjeet; Figliola, Matthew J.; Dawson, Margaret J.; Olivares, Simon; Zhang, Ling; Yang, Ge; Maiti, Sourindra; Manuri, Pallavi R.; Senyukov, Vladimir; Jena, Bipulendu; Kebriaei, Partow; Champlin, Richard E.; Huls, Helen; Cooper, Laurence J.N.

Year: 2013

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0064138

Paper CD19 CAR-Targeted T Cells Induce Long-Term Remission and B Cell Aplasia in an Immunocompetent Mouse Model of B Cell Acute Lymphoblastic Leukemia

Davila, Marco L.; Kloss, Christopher C.; Gunset, Gertrude et al. · 2013 · PLoS ONE · DOI

Full title: CD19 CAR-Targeted T Cells Induce Long-Term Remission and B Cell Aplasia in an Immunocompetent Mouse Model of B Cell Acute Lymphoblastic Leukemia

Authors: Davila, Marco L.; Kloss, Christopher C.; Gunset, Gertrude; Sadelain, Michel

Year: 2013

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0061338

Paper Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8+ Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell Therapy

Chacon, Jessica; Wu, Richard C.; Sukhumalchandra, Pariya et al. · 2013 · PLoS ONE · DOI

Full title: Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8+ Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell Therapy

Authors: Chacon, Jessica; Wu, Richard C.; Sukhumalchandra, Pariya; Molldrem, Jeffrey J.; Sarnaik, Amod A.; Pilon‐Thomas, Shari; Weber, Jeffrey S.; Hwu, Patrick; Radvanyi, Laszlo

Year: 2013

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0060031

Paper In vitro immunotherapy potency assays using real-time cell analysis

Cerignoli, Fabio; Abassi, Yama; Lamarche, Brandon J. et al. · 2018 · PLoS ONE · DOI

Full title: In vitro immunotherapy potency assays using real-time cell analysis

Authors: Cerignoli, Fabio; Abassi, Yama; Lamarche, Brandon J.; Guenther, Garret; Ana, David Santa; Guimet, Diana; Zhang, Wen; Zhang, Jing; Xi, Brian

Year: 2018

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0193498

Paper Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations

Deniger, Drew C.; Yu, Jianqiang; Huls, M. Helen et al. · 2015 · PLoS ONE · DOI

Full title: Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations

Authors: Deniger, Drew C.; Yu, Jianqiang; Huls, M. Helen; Figliola, Matthew J.; Mi, Tiejuan; Maiti, Sourindra N.; Widhopf, George F.; Hurton, Lenka V.; Thokala, Radhika; Singh, Harjeet; Olivares, Simon; Champlin, Richard E.; Wierda, William G.; Kipps, Thomas J.; Cooper, Laurence J.N.

Year: 2015

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0128151

Paper Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors

Karlsson, Hannah; Svensson, Emma; Gigg, Camilla et al. · 2015 · PLoS ONE · DOI

Full title: Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors

Authors: Karlsson, Hannah; Svensson, Emma; Gigg, Camilla; Jarvius, Malin; Olsson‐Strömberg, Ulla; Savoldo, Barbara; Dotti, Gianpietro; Loskog, Angelica

Year: 2015

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0144787

Paper Combining a CD20 Chimeric Antigen Receptor and an Inducible Caspase 9 Suicide Switch to Improve the Efficacy and Safety of T Cell Adoptive Immunotherapy for Lymphoma

Budde, Lihua E.; Berger, Carolina; Lin, Yukang et al. · 2013 · PLoS ONE · DOI

Full title: Combining a CD20 Chimeric Antigen Receptor and an Inducible Caspase 9 Suicide Switch to Improve the Efficacy and Safety of T Cell Adoptive Immunotherapy for Lymphoma

Authors: Budde, Lihua E.; Berger, Carolina; Lin, Yukang; Wang, Jinjuan; Lin, Xubin; Frayo, Shani E.; Brouns, Shaunda A.; Spencer, David M.; Till, Brian G.; Jensen, Michael C.; Riddell, Stanley R.; Press, Oliver W.

Year: 2013

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0082742

Paper GM-CSF perturbs cell identity in mouse pre-implantation embryos

T. Pock; K. Schulte; S. Schlatt et al. · 2022 · PLoS ONE · DOI

Full title: GM-CSF perturbs cell identity in mouse pre-implantation embryos

Authors: T. Pock; K. Schulte; S. Schlatt; M. Boiani; V. Nordhoff

Year: 2022

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0263793

Paper Redirecting T Cells to Ewing's Sarcoma Family of Tumors by a Chimeric NKG2D Receptor Expressed by Lentiviral Transduction or mRNA Transfection

Lehner, Manfred; Götz, Gabriel; Proff, Julia et al. · 2012 · PLoS ONE · DOI

Full title: Redirecting T Cells to Ewing's Sarcoma Family of Tumors by a Chimeric NKG2D Receptor Expressed by Lentiviral Transduction or mRNA Transfection

Authors: Lehner, Manfred; Götz, Gabriel; Proff, Julia; Schaft, Niels; Dörrie, Jan; Full, Florian; Ensser, Armin; Muller, Yves A.; Cerwenka, Adelheid; Abken, Hinrich; Parolini, Ornella; Ambros, Peter F.; Kovar, Heinrich; Holter, Wolfgang

Year: 2012

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0031210

Paper Multiparameter comparative analysis reveals differential impacts of various cytokines on CART cell phenotype and function ex vivo and in vivo

Xu, Xiaojun; Song, De-Gang; Poussin, Mathilde et al. · 2016 · Oncotarget · DOI

Full title: Multiparameter comparative analysis reveals differential impacts of various cytokines on CART cell phenotype and function ex vivo and in vivo

Authors: Xu, Xiaojun; Song, De-Gang; Poussin, Mathilde; Ye, Qunrui; Sharma, Prannda; Rodríguez-García, Alba; Tang, Yongmin; Powell, Daniel J.

Year: 2016

Venue: Oncotarget

DOI: https://doi.org/10.18632/oncotarget.10510

Paper PD1 blockade enhances cytotoxicity of in vitro expanded natural killer cells towards myeloma cells

Guo, Yanan; Feng, Xiaoli; Jiang, Yang et al. · 2016 · Oncotarget · DOI

Full title: PD1 blockade enhances cytotoxicity of in vitro expanded natural killer cells towards myeloma cells

Authors: Guo, Yanan; Feng, Xiaoli; Jiang, Yang; Shi, Xiaoyun; Xing, Xiangling; Liu, Xiaoli; Li, Nailin; Fadeel, Bengt; Zheng, Chengyun

Year: 2016

Venue: Oncotarget

DOI: https://doi.org/10.18632/oncotarget.10235

Paper Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor

Schutsky, Keith; Song, De-Gang; Lynn, Rachel C. et al. · 2015 · Oncotarget · DOI

Full title: Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor

Authors: Schutsky, Keith; Song, De-Gang; Lynn, Rachel C.; Smith, Jenessa B.; Poussin, Mathilde; Figini, Mariangela; Zhao, Yangbing; Powell, Daniel J.

Year: 2015

Venue: Oncotarget

DOI: https://doi.org/10.18632/oncotarget.5029

Paper Immunotherapy of acute leukemia by chimeric antigen receptor-modified lymphocytes using an improved Sleeping Beauty transposon platform

Chiara F. Magnani; N. Turazzi; F. Benedicenti et al. · 2016 · OncoTarget · DOI

Full title: Immunotherapy of acute leukemia by chimeric antigen receptor-modified lymphocytes using an improved Sleeping Beauty transposon platform

Authors: Chiara F. Magnani; N. Turazzi; F. Benedicenti; A. Calabria; Erika Tenderini; Sarah Tettamanti; G. G. Attianese; L. Cooper; A. Aiuti; E. Montini; A. Biondi; E. Biagi

Year: 2016

Venue: OncoTarget

DOI: https://doi.org/10.18632/oncotarget.9955

Paper Culturing adequate CAR-T cells from less peripheral blood to treat B-cell malignancies

Lu Han; Jian Zhou; Lin-Lin Li et al. · 2021 · Cancer Biology and Medicine · DOI

Full title: Culturing adequate CAR-T cells from less peripheral blood to treat B-cell malignancies

Authors: Lu Han; Jian Zhou; Lin-Lin Li; K. Zhou; Lingdi Zhao; Xing-hu Zhu; Q. Yin; Yu-Fu Li; Hongqin You; Jishuai Zhang; Yongping Song; Quanli Gao

Year: 2021

Venue: Cancer Biology and Medicine

DOI: https://doi.org/10.20892/j.issn.2095-3941.2021.0040

Paper CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia

Vairy, Stéphanie; Garcia, Júlia Lopes; Teira, Pierre et al. · 2018 · Drug Design Development and Therapy · DOI

Full title: CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia

Authors: Vairy, Stéphanie; Garcia, Júlia Lopes; Teira, Pierre; Bittencourt, Henrique

Year: 2018

Venue: Drug Design Development and Therapy

DOI: https://doi.org/10.2147/dddt.s138765

Paper Clinical Application of Cytokines in Cancer Immunotherapy

Qiu, Yi; Su, Mengxi; Liu, Leyi et al. · 2021 · Drug Design Development and Therapy · DOI

Full title: Clinical Application of Cytokines in Cancer Immunotherapy

Authors: Qiu, Yi; Su, Mengxi; Liu, Leyi; Tang, Yiqi; Pan, Yuan; Sun, Jianbo

Year: 2021

Venue: Drug Design Development and Therapy

DOI: https://doi.org/10.2147/dddt.s308578

Paper Characterization of CAR T Cells Manufactured Using Genetically Engineered Artificial Antigen Presenting Cells

Ali Sayadmanesh; M. Azadbakht; K. Yari et al. · 2023 · bioRxiv · DOI

Full title: Characterization of CAR T Cells Manufactured Using Genetically Engineered Artificial Antigen Presenting Cells

Authors: Ali Sayadmanesh; M. Azadbakht; K. Yari; Ali Abedelahi; Hajar Shafaei; D. Shanehbandi; B. Baradaran; M. Basiri

Year: 2023

Venue: bioRxiv

DOI: https://doi.org/10.22074/cellj.2023.2001712.1304

Paper Preclinical development of a protocol for the manufacturing of anti-CD5 CAR-T lymphocytes for the treatment of T-lineage acute lymphoblastic leukemia and lymphoma

E. Musaeva; E. Malakhova; Victoria A. Vedmedskaia et al. · 2025 · Pediatric Hematology/Oncology and Immunopathology · DOI

Full title: Preclinical development of a protocol for the manufacturing of anti-CD5 CAR-T lymphocytes for the treatment of T-lineage acute lymphoblastic leukemia and lymphoma

Authors: E. Musaeva; E. Malakhova; Victoria A. Vedmedskaia; D. Osipova; Dmitry V. Volkov; Aleksander Chernov; A. Fedorova; M. Fadeeva; Oyuna B. Lodoeva; E. Kulakovskaya; T. Sozonova; Alexey V. Stepanov; D. Pershin; M. Maschan

Year: 2025

Venue: Pediatric Hematology/Oncology and Immunopathology

DOI: https://doi.org/10.24287/1726-1708-2025-24-2-14-26

Paper Comparative characterization of the cell composition and functional properties of anti-CD19 biomedical cell products manufactured using the CliniMACS Prodigy and G-Rex platforms

E. Malakhova; D. Pershin; V. Vedmedskaia et al. · 2024 · Pediatric Hematology/Oncology and Immunopathology · DOI

Full title: Comparative characterization of the cell composition and functional properties of anti-CD19 biomedical cell products manufactured using the CliniMACS Prodigy and G-Rex platforms

Authors: E. Malakhova; D. Pershin; V. Vedmedskaia; M. Fadeeva; E. Kulakovskaya; O. Lodoeva; T. Sozonova; E. Musaeva; Y. Muzalevskii; A. Kazachenok; V. Belchikov; A. Melkova; L. Shelikhova; O. Molostova; E. Badrin; M. Maschan

Year: 2024

Venue: Pediatric Hematology/Oncology and Immunopathology

DOI: https://doi.org/10.24287/1726-1708-2024-23-2-128-139

Paper CD28.OX40 co-stimulatory combination is associated with long in vivo persistence and high activity of CAR.CD30 T cells

M. Guercio; D. Orlando; S. Di Cecca et al. · 2020 · Haematologica · DOI

Full title: CD28.OX40 co-stimulatory combination is associated with long in vivo persistence and high activity of CAR.CD30 T cells

Authors: M. Guercio; D. Orlando; S. Di Cecca; M. Sinibaldi; I. Boffa; S. Caruso; Z. Abbaszadeh; A. Camera; B. Cembrola; Katia Bovetti; Simona Manni; Ignazio Caruana; Roselia Ciccone; F. del Bufalo; P. Merli; L. Vinti; Katia Girardi; A. Ruggeri; C. De Stefanis; M. Pezzullo; E. Giorda; M. Scarsella; R. de Vito; S. Barresi; A. Ciolfi; M. Tartaglia; L. Moretta; F. Locatelli; C. Quintarelli; B. De Angelis

Year: 2020

Venue: Haematologica

DOI: https://doi.org/10.3324/haematol.2019.231183

Paper Chimeric antigen receptor T-cell therapy in childhood acute myeloid leukemia: how far are we from a clinical application?

Swati Naik; M. Velasquez; Stephen Gottschalk · 2024 · Haematologica · DOI

Full title: Chimeric antigen receptor T-cell therapy in childhood acute myeloid leukemia: how far are we from a clinical application?

Authors: Swati Naik; M. Velasquez; Stephen Gottschalk

Year: 2024

Venue: Haematologica

DOI: https://doi.org/10.3324/haematol.2023.283817

Paper Umbilical cord blood T cells can be isolated and enriched by CD62L selection for use in ‘off the shelf’ chimeric antigen receptor T-cell therapies to widen transplant options

C. Georgiadis; Lauren E Nickolay; Farhatullah Syed et al. · 2024 · Haematologica · DOI

Full title: Umbilical cord blood T cells can be isolated and enriched by CD62L selection for use in ‘off the shelf’ chimeric antigen receptor T-cell therapies to widen transplant options

Authors: C. Georgiadis; Lauren E Nickolay; Farhatullah Syed; H. Zhan; S. A. Gkazi; Annie Etuk; Ulrike Abramowski-Mock; Roland Preece; Piotr Cuber; Stuart Adams; Giorgio Ottaviano; W. Qasim

Year: 2024

Venue: Haematologica

DOI: https://doi.org/10.3324/haematol.2024.285101

Paper Excellent proliferation and persistence of allogeneic donor-derived 41-BB based CAR-T cells despite immunosuppression with cyclosporine A

F. Ayuk; B. Fehse; D. Janson et al. · 2020 · Haematologica · DOI

Full title: Excellent proliferation and persistence of allogeneic donor-derived 41-BB based CAR-T cells despite immunosuppression with cyclosporine A

Authors: F. Ayuk; B. Fehse; D. Janson; C. Berger; K. Riecken; N. Kröger

Year: 2020

Venue: Haematologica

DOI: https://doi.org/10.3324/haematol.2019.245969

Paper Analytical and computational studies predict negligible risk of cell death from eddy generation off flat surfaces in cell culture flow systems

Elliot J. Morley; C. Brockett; S. W. Verbruggen · 2024 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Analytical and computational studies predict negligible risk of cell death from eddy generation off flat surfaces in cell culture flow systems

Authors: Elliot J. Morley; C. Brockett; S. W. Verbruggen

Year: 2024

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2024.1340653

Paper Piloting a scale-up platform for high-quality human T-cells production

V. Selvarajan; Denise Bei Lin Teo; Chaw-Chiea Chang et al. · 2024 · Frontiers in Cell and Developmental Biology · DOI

Full title: Piloting a scale-up platform for high-quality human T-cells production

Authors: V. Selvarajan; Denise Bei Lin Teo; Chaw-Chiea Chang; Yuen Ling Ng; Nge Cheong; Jaichandran Sivalingam; Soo Hean Gary Khoo; Adison Wong; Bernard Liat Wen Loo

Year: 2024

Venue: Frontiers in Cell and Developmental Biology

DOI: https://doi.org/10.3389/fcell.2024.1427171

Paper Tailored Cytokine Optimization for ex vivo Culture Platforms Targeting the Expansion of Human Hematopoietic Stem/Progenitor Cells

A. Branco; S. Bucar; Jorge Moura-Sampaio et al. · 2020 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Tailored Cytokine Optimization for ex vivo Culture Platforms Targeting the Expansion of Human Hematopoietic Stem/Progenitor Cells

Authors: A. Branco; S. Bucar; Jorge Moura-Sampaio; C. Lilaia; J. Cabral; A. Fernandes-Platzgummer; C. Lobato da Silva

Year: 2020

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2020.573282

Paper Optimising and adapting perfusion feeds in serum-free medium to intensify CAR-T cell expansion in stirred-tank bioreactors.

Springuel, Pierre; Hood, Tiffany; Slingsby, Fern et al. · 2025 · Frontiers in bioengineering and biotechnology · DOI

Full title: Optimising and adapting perfusion feeds in serum-free medium to intensify CAR-T cell expansion in stirred-tank bioreactors.

Authors: Springuel, Pierre; Hood, Tiffany; Slingsby, Fern; Schmidberger, Timo; Bevan, Nicola; Dianat, Noushin; Hengst, Julia; Rafiq, Qasim A

Year: 2025

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2025.1593895

Paper TCR-Engineered T Cells Meet New Challenges to Treat Solid Tumors: Choice of Antigen, T Cell Fitness, and Sensitization of Tumor Milieu

Kunert, André; Straetemans, Trudy; Govers, Coen et al. · 2013 · Frontiers in Immunology · DOI

Full title: TCR-Engineered T Cells Meet New Challenges to Treat Solid Tumors: Choice of Antigen, T Cell Fitness, and Sensitization of Tumor Milieu

Authors: Kunert, André; Straetemans, Trudy; Govers, Coen; Lamers, C. B. H. W.; Mathijssen, Ron H.J.; Sleijfer, Stefan; Debets, Reno

Year: 2013

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2013.00363

Paper Natural Killer Cells for Cancer Immunotherapy: Pluripotent Stem Cells-Derived NK Cells as an Immunotherapeutic Perspective

Eguizábal, Cristina; Zenarruzabeitia, Olatz; Monge, Jorge et al. · 2014 · Frontiers in Immunology · DOI

Full title: Natural Killer Cells for Cancer Immunotherapy: Pluripotent Stem Cells-Derived NK Cells as an Immunotherapeutic Perspective

Authors: Eguizábal, Cristina; Zenarruzabeitia, Olatz; Monge, Jorge; Santos, Silvia; Vesga, Miguel Ángel; Maruri, Natalia; Arrieta, Arantza; n, Marta RiÃ±Ã; Tamayo-Orbegozo, Estíbaliz; Amo, Laura; Larrucea, Susana; Borrego, Francisco

Year: 2014

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2014.00439

Paper Natural Killer Cell-Based Therapies Targeting Cancer: Possible Strategies to Gain and Sustain Anti-Tumor Activity

Dahlberg, Carin; Sarhan, Dhifaf; Chrobok, Michael et al. · 2015 · Frontiers in Immunology · DOI

Full title: Natural Killer Cell-Based Therapies Targeting Cancer: Possible Strategies to Gain and Sustain Anti-Tumor Activity

Authors: Dahlberg, Carin; Sarhan, Dhifaf; Chrobok, Michael; Duru, Adil Doganay; Alici, Evren

Year: 2015

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2015.00605

Paper Plasticity of Î³Î´ T Cells: Impact on the Anti-Tumor Response

Lafont, Virginie; Sanchez, FranÃ§oise; Laprévotte, Emilie et al. · 2014 · Frontiers in Immunology · DOI

Full title: Plasticity of Î³Î´ T Cells: Impact on the Anti-Tumor Response

Authors: Lafont, Virginie; Sanchez, FranÃ§oise; Laprévotte, Emilie; Michaud, Henri‐Alexandre; Gros, Laurent; Eliaou, Jean-FranÃ§ois; Bonnefoy, Nathalie

Year: 2014

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2014.00622

Paper The Application of Natural Killer Cell Immunotherapy for the Treatment of Cancer

Rezvani, Katayoun; Rouce, Rayne H. · 2015 · Frontiers in Immunology · DOI

Full title: The Application of Natural Killer Cell Immunotherapy for the Treatment of Cancer

Authors: Rezvani, Katayoun; Rouce, Rayne H.

Year: 2015

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2015.00578

Paper Shaping of Natural Killer Cell Antitumor Activity by Ex Vivo Cultivation

Granzin, Markus; Wagner, Juliane; Köhl, Ulrike et al. · 2017 · Frontiers in Immunology · DOI

Full title: Shaping of Natural Killer Cell Antitumor Activity by Ex Vivo Cultivation

Authors: Granzin, Markus; Wagner, Juliane; Köhl, Ulrike; Cerwenka, Adelheid; Huppert, Volker; Ullrich, Evelyn

Year: 2017

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2017.00458

Paper Genetic Manipulation of NK Cells for Cancer Immunotherapy: Techniques and Clinical Implications

Carlsten, Mattias; Childs, Richard · 2015 · Frontiers in Immunology · DOI

Full title: Genetic Manipulation of NK Cells for Cancer Immunotherapy: Techniques and Clinical Implications

Authors: Carlsten, Mattias; Childs, Richard

Year: 2015

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2015.00266

Paper Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation

Safinia, Niloufar; Scottà, Cristiano; Vaikunthanathan, Trishan et al. · 2015 · Frontiers in Immunology · DOI

Full title: Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation

Authors: Safinia, Niloufar; Scottà, Cristiano; Vaikunthanathan, Trishan; Lechler, Robert I.; Lombardi, Giovanna

Year: 2015

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2015.00438

Paper The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments

Veluchamy, John P.; Kok, Nina; Vliet, Hans van et al. · 2017 · Frontiers in Immunology · DOI

Full title: The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments

Authors: Veluchamy, John P.; Kok, Nina; Vliet, Hans van; Verheul, Henk M.W.; Gruijl, Tanja D. de; Spanholtz, Jan

Year: 2017

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2017.00631

Paper Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination

Redeker, Anke; Arens, Ramon · 2016 · Frontiers in Immunology · DOI

Full title: Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination

Authors: Redeker, Anke; Arens, Ramon

Year: 2016

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2016.00345

Paper Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel.

Irving, Melita; Vuillefroy de Silly, Romain; Scholten, Kirsten et al. · 2017 · Frontiers in immunology · DOI

Full title: Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel.

Authors: Irving, Melita; Vuillefroy de Silly, Romain; Scholten, Kirsten; Dilek, Nahzli; Coukos, George

Year: 2017

Venue: Frontiers in immunology

DOI: https://doi.org/10.3389/fimmu.2017.00267

Paper Chimeric Antigen Receptors T Cell Therapy in Solid Tumor: Challenges and Clinical Applications

Mirzaei, Hamid Reza; Rodriguez, Analiz; Shepphird, Jennifer Kelly et al. · 2017 · Frontiers in Immunology · DOI

Full title: Chimeric Antigen Receptors T Cell Therapy in Solid Tumor: Challenges and Clinical Applications

Authors: Mirzaei, Hamid Reza; Rodriguez, Analiz; Shepphird, Jennifer Kelly; Brown, Christine E.; Badie, Behnam

Year: 2017

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2017.01850

Paper NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development

Dezfouli, Ali Bashiri; Yazdi, Mina; Pockley, A. Graham et al. · 2021 · Cells · DOI

Full title: NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development

Authors: Dezfouli, Ali Bashiri; Yazdi, Mina; Pockley, A. Graham; Khosravi, Mohammad; Kobold, Sebastian; Wagner, Ernst; Multhoff, Gabriele

Year: 2021

Venue: Cells

DOI: https://doi.org/10.3390/cells10123390

Paper Improving CAR T-Cell Persistence

Violena Pietrobon; L. A. Todd; Anghsumala Goswami et al. · 2021 · International Journal of Molecular Sciences · DOI

Full title: Improving CAR T-Cell Persistence

Authors: Violena Pietrobon; L. A. Todd; Anghsumala Goswami; Ofir Stefanson; Zhifen Yang; F. Marincola

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms221910828

Paper BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia

Kong, Weimin; Dimitri, Alexander J.; Wenliang, Wang et al. · 2021 · Journal of Clinical Investigation · DOI

Full title: BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia

Authors: Kong, Weimin; Dimitri, Alexander J.; Wenliang, Wang; Jung, In-Young; Ott, Christopher J.; Fasolino, Maria; Wang, Yan; Kulikovskaya, Irina; Gupta, Minnal; Yoder, Todd; DeNizio, Jamie E.; Everett, J.K.; Williams, Erik F.; Xu, Jun; Scholler, John; Reich, Tyler J.; Bhoj, Vijay; Haines, Kathleen M.; Maus, Marcela V.; Melenhorst, J. Joseph; Young, Regina M.; Jadlowsky, Julie K.; Marcucci, Katherine T.; Bradner, James E.; Levine, Bruce L.; Porter, David L.; Bushman, Frederic D.; Kohli, Rahul M.; June, Carl H.; Davis, Megan M.; Lacey, Simon F.; Vahedi, Golnaz; Fraietta, Joseph A.

Year: 2021

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci145459

Paper Sleeping Beauty-engineered CAR T cells achieve anti-leukemic activity without severe toxicities.

Chiara F. Magnani; G. Gaipa; F. Lussana et al. · 2020 · Journal of Clinical Investigation · DOI

Full title: Sleeping Beauty-engineered CAR T cells achieve anti-leukemic activity without severe toxicities.

Authors: Chiara F. Magnani; G. Gaipa; F. Lussana; D. Belotti; G. Gritti; S. Napolitano; G. Matera; Benedetta Cabiati; C. Buracchi; G. Borleri; G. Fazio; Silvia Zaninelli; Sarah Tettamanti; S. Cesana; V. Colombo; Michele Quaroni; G. Cazzaniga; A. Rovelli; E. Biagi; S. Galimberti; A. Calabria; F. Benedicenti; E. Montini; S. Ferrari; M. Introna; A. Balduzzi; M. Valsecchi; G. Dastoli; A. Rambaldi; A. Biondi

Year: 2020

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci138473

Paper CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome.

Arcangeli, Silvia; Bove, Camilla; Mezzanotte, Claudia et al. · 2022 · The Journal of clinical investigation · DOI

Full title: CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome.

Authors: Arcangeli, Silvia; Bove, Camilla; Mezzanotte, Claudia; Camisa, Barbara; Falcone, Laura; Manfredi, Francesco; Bezzecchi, Eugenia; El Khoury, Rita; Norata, Rossana; Sanvito, Francesca; Ponzoni, Maurilio; Greco, Beatrice; Moresco, Marta Angiola; Carrabba, Matteo G; Ciceri, Fabio; Bonini, Chiara; Bondanza, Attilio; Casucci, Monica

Year: 2022

Venue: The Journal of clinical investigation

DOI: https://doi.org/10.1172/JCI150807

Paper CAR therapy: the CD19 paradigm

Sadelain, Michel · 2015 · Journal of Clinical Investigation · DOI

Full title: CAR therapy: the CD19 paradigm

Authors: Sadelain, Michel

Year: 2015

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci80010

Paper CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients.

C. Turtle; L. Hanafi; C. Berger et al. · 2016 · Journal of Clinical Investigation · DOI

Full title: CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients.

Authors: C. Turtle; L. Hanafi; C. Berger; T. Gooley; S. Cherian; M. Hudecek; D. Sommermeyer; Katherine Melville; B. Pender; Tanya M Budiarto; E. Robinson; Natalia N Steevens; Colette N. Chaney; L. Soma; Xueyan Chen; C. Yeung; B. Wood; Daniel H. Li; Jianhong Cao; S. Heimfeld; M. Jensen; S. Riddell; D. Maloney

Year: 2016

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci85309

Paper Transient stimulation expands superior antitumor T cells for adoptive therapy

Kagoya, Yuki; Nakatsugawa, Munehide; Ochi, Toshiki et al. · 2017 · JCI Insight · DOI

Full title: Transient stimulation expands superior antitumor T cells for adoptive therapy

Authors: Kagoya, Yuki; Nakatsugawa, Munehide; Ochi, Toshiki; Cen, Yuchen; Guo, Tingxi; Anczurowski, Mark; Saso, Kayoko; Butler, Marcus O.; Hirano, Naoto

Year: 2017

Venue: JCI Insight

DOI: https://doi.org/10.1172/jci.insight.89580

Paper Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation

Guedan, Sònia; Posey, Avery D.; Shaw, Carolyn E. et al. · 2018 · JCI Insight · DOI

Full title: Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation

Authors: Guedan, Sònia; Posey, Avery D.; Shaw, Carolyn E.; Wing, Anna; Da, Tong; Patel, Prachi; McGettigan, Shannon E.; Casado‐Medrano, Victoria; Kawalekar, Omkar U.; Uribe‐Herranz, Mireia; Song, Decheng; Melenhorst, J. Joseph; Lacey, Simon F.; Scholler, John; Keith, Brian; Young, Regina M.; June, Carl H.

Year: 2018

Venue: JCI Insight

DOI: https://doi.org/10.1172/jci.insight.96976

Paper Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection

Parrot, Tiphaine; Healy, Katie; Boulouis, Caroline et al. · 2021 · JCI Insight · DOI

Full title: Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection

Authors: Parrot, Tiphaine; Healy, Katie; Boulouis, Caroline; Sobkowiak, Michał J.; Leeansyah, Edwin; Aleman, Soo; Bertoletti, Antonio; Chen, Margaret; Sandberg, Johan K.

Year: 2021

Venue: JCI Insight

DOI: https://doi.org/10.1172/jci.insight.140074

Paper Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity

Wang, Dongrui; Aguilar, Brenda; Starr, Renate et al. · 2018 · JCI Insight · DOI

Full title: Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity

Authors: Wang, Dongrui; Aguilar, Brenda; Starr, Renate; Alizadeh, Darya; Brito, Alfonso; Sarkissian, Aniee; Ostberg, Julie R.; Forman, Stephen J.; Brown, Christine E.

Year: 2018

Venue: JCI Insight

DOI: https://doi.org/10.1172/jci.insight.99048

Paper Building a Better Defense: Expanding and Improving Natural Killer Cells for Adoptive Cell Therapy

Maia, Andreia; Tarannum, Mubin; Lérias, Joana R. et al. · 2024 · Cells · DOI

Full title: Building a Better Defense: Expanding and Improving Natural Killer Cells for Adoptive Cell Therapy

Authors: Maia, Andreia; Tarannum, Mubin; Lérias, Joana R.; Piccinelli, Sara; Borrego, Luís Miguel; Maeurer, Markus; Romee, Rizwan; Castillo-Martín, Mireia

Year: 2024

Venue: Cells

DOI: https://doi.org/10.3390/cells13050451

Paper ‘Off-the-Shelf’ Immunotherapy: Manufacture of CD8+ T Cells Derived from Hematopoietic Stem Cells

N. Boyd; K. Cartledge; H. Cao et al. · 2021 · Cells · DOI

Full title: ‘Off-the-Shelf’ Immunotherapy: Manufacture of CD8+ T Cells Derived from Hematopoietic Stem Cells

Authors: N. Boyd; K. Cartledge; H. Cao; V. Evtimov; Aleta Pupovac; A. Trounson; R. Boyd

Year: 2021

Venue: Cells

DOI: https://doi.org/10.3390/cells10102631

Paper Recent Advances in CAR-Based Solid Tumor Immunotherapy

Shin, Min Hwa; Oh, Eunha; Kim, Yun Jeong et al. · 2023 · Cells · DOI

Full title: Recent Advances in CAR-Based Solid Tumor Immunotherapy

Authors: Shin, Min Hwa; Oh, Eunha; Kim, Yun Jeong; Nam, Dae-Hwan; Jeon, Soyoung; Yu, Jin Hyuk; Minn, Dohsik

Year: 2023

Venue: Cells

DOI: https://doi.org/10.3390/cells12121606

Paper IL7-IL12 Engineered Mesenchymal Stem Cells (MSCs) Improve A CAR T Cell Attack Against Colorectal Cancer Cells

Hombach, Andreas; Geumann, Ulf; Günther, Christine et al. · 2020 · Cells · DOI

Full title: IL7-IL12 Engineered Mesenchymal Stem Cells (MSCs) Improve A CAR T Cell Attack Against Colorectal Cancer Cells

Authors: Hombach, Andreas; Geumann, Ulf; Günther, Christine; Hermann, Felix G.; Abken, Hinrich

Year: 2020

Venue: Cells

DOI: https://doi.org/10.3390/cells9040873

Paper Investigation of the Impact from IL-2, IL-7, and IL-15 on the Growth and Signaling of Activated CD4+ T Cells

Canaan Coppola; B. Hopkins; S. Huhn et al. · 2020 · International Journal of Molecular Sciences · DOI

Full title: Investigation of the Impact from IL-2, IL-7, and IL-15 on the Growth and Signaling of Activated CD4+ T Cells

Authors: Canaan Coppola; B. Hopkins; S. Huhn; Z. Du; Z. Huang; W. Kelly

Year: 2020

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms21217814

Paper Interleukin 15 in Cell-Based Cancer Immunotherapy

Zhou, Yang; Husman, Tiffany; Cen, Xinjian et al. · 2022 · International Journal of Molecular Sciences · DOI

Full title: Interleukin 15 in Cell-Based Cancer Immunotherapy

Authors: Zhou, Yang; Husman, Tiffany; Cen, Xinjian; Tsao, Tasha; Brown, James; Bajpai, Aarushi; Li, Miao; Zhou, Kuangyi; Yang, Lili

Year: 2022

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms23137311

Paper The Generation of CAR-Transfected Natural Killer T Cells for the Immunotherapy of Melanoma

Simon, Bianca; Wiesinger, Manuel; März, Johannes et al. · 2018 · International Journal of Molecular Sciences · DOI

Full title: The Generation of CAR-Transfected Natural Killer T Cells for the Immunotherapy of Melanoma

Authors: Simon, Bianca; Wiesinger, Manuel; März, Johannes; Wistuba‐Hamprecht, Kilian; Weide, Benjamin; Schuler‐Thurner, Beatrice; Schuler, Gerold; Dörrie, Jan; Uslu, Uğur

Year: 2018

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms19082365

Paper CAR-NK Cells Generated with mRNA-LNPs Kill Tumor Target Cells In Vitro and In Vivo

Golubovskaya, Vita; Sienkiewicz, John; Sun, Jinying et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: CAR-NK Cells Generated with mRNA-LNPs Kill Tumor Target Cells In Vitro and In Vivo

Authors: Golubovskaya, Vita; Sienkiewicz, John; Sun, Jinying; Zhang, Shiming; Huang, Yanwei; Zhou, Hua; Harto, Hizkia; Xu, Shirley; Berahovich, Robert; Wu, Lijun

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms241713364

Paper Optimizing Manufacturing Protocols of Chimeric Antigen Receptor T Cells for Improved Anticancer Immunotherapy

S. Stock; M. Schmitt; L. Sellner · 2019 · International Journal of Molecular Sciences · DOI

Full title: Optimizing Manufacturing Protocols of Chimeric Antigen Receptor T Cells for Improved Anticancer Immunotherapy

Authors: S. Stock; M. Schmitt; L. Sellner

Year: 2019

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms20246223

Paper CAR T-Cell Therapy in Hematological Malignancies

Haslauer, Theresa; Greil, Richard; Zaborsky, Nadja et al. · 2021 · International Journal of Molecular Sciences · DOI

Full title: CAR T-Cell Therapy in Hematological Malignancies

Authors: Haslauer, Theresa; Greil, Richard; Zaborsky, Nadja; Geisberger, Roland

Year: 2021

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms22168996

Paper CAR T-Cell Persistence Correlates with Improved Outcome in Patients with B-Cell Lymphoma

Wittibschlager, Valerie; Bacher, Ulrike; Seipel, Katja et al. · 2023 · International Journal of Molecular Sciences · DOI

Full title: CAR T-Cell Persistence Correlates with Improved Outcome in Patients with B-Cell Lymphoma

Authors: Wittibschlager, Valerie; Bacher, Ulrike; Seipel, Katja; Porret, Naomi; Wiedemann, Gertrud; Haslebacher, Claudia; Hoffmann, Michèle J.; Daskalakis, Michael; Akhoundova, Dilara; Pabst, Thomas

Year: 2023

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms24065688

Paper Upregulation of the TCA Cycle and Oxidative Phosphorylation Enhances the Fitness of CD99 CAR-T Cells Under Dynamic Cultivation

Jiaxuan Zhao; Youyong Wang; Yixuan Wang et al. · 2026 · International Journal of Molecular Sciences · DOI

Full title: Upregulation of the TCA Cycle and Oxidative Phosphorylation Enhances the Fitness of CD99 CAR-T Cells Under Dynamic Cultivation

Authors: Jiaxuan Zhao; Youyong Wang; Yixuan Wang; Ge Dong; Han Wu; Yeting Cui; Lixing Gu; Fenfang Zhao; Guanlin Zhao; Jinyu Kang; Qian Zhang; Nan Liu; Ning Wang; Xiao Sun; Yao Xu; Tongcun Zhang; Jiangzhou Shi

Year: 2026

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms27020607

Paper CliniMACS Prodigy Manufacturing of Switchable, AND-Gate CAR T Cells

Alexandra von Jutrzenka-Trzebiatowski; R. Gupte; Cansu Daglar et al. · 2025 · International Journal of Molecular Sciences · DOI

Full title: CliniMACS Prodigy Manufacturing of Switchable, AND-Gate CAR T Cells

Authors: Alexandra von Jutrzenka-Trzebiatowski; R. Gupte; Cansu Daglar; N. Berndt; C. Arndt; Michael Bachmann; A. Feldmann

Year: 2025

Venue: International Journal of Molecular Sciences

DOI: https://doi.org/10.3390/ijms26115024

Paper Rapidly Manufactured CAR-T with Conserved Cell Stemness and Distinctive Cytokine-Secreting Profile Shows Improved Anti-Tumor Efficacy

Shih-Ting Tsao; Mingyuan Gu; Qinghui Xiong et al. · 2024 · Vaccines · DOI

Full title: Rapidly Manufactured CAR-T with Conserved Cell Stemness and Distinctive Cytokine-Secreting Profile Shows Improved Anti-Tumor Efficacy

Authors: Shih-Ting Tsao; Mingyuan Gu; Qinghui Xiong; Yingzhi Deng; Tian Deng; Chengbing Fu; Zihao Zhao; Haoyu Zhang; Cuicui Liu; Xiong Zhong; Fang Xiang; Fei Huang; Haiying Wang

Year: 2024

Venue: Vaccines

DOI: https://doi.org/10.3390/vaccines12121348

Paper Chimeric Antigen Receptor-T-Cell Therapy for B-Cell Hematological Malignancies: An Update of the Pivotal Clinical Trial Data

Roex, Gils; Feys, Tom; Béguin, Yves et al. · 2020 · Pharmaceutics · DOI

Full title: Chimeric Antigen Receptor-T-Cell Therapy for B-Cell Hematological Malignancies: An Update of the Pivotal Clinical Trial Data

Authors: Roex, Gils; Feys, Tom; Béguin, Yves; Kerre, Tessa; Poiré, Xavier; Lewalle, Philippe; Vandenberghe, Peter; Bron, Dominique; Anguille, Sébastien

Year: 2020

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics12020194

Paper Membrane Applications in Autologous Cell Therapy

R. Martin; Rui Lei; Yida Zeng et al. · 2022 · Membranes · DOI

Full title: Membrane Applications in Autologous Cell Therapy

Authors: R. Martin; Rui Lei; Yida Zeng; Jiachen Zhu; Hong Chang; H. Ye; Zhanfeng Cui

Year: 2022

Venue: Membranes

DOI: https://doi.org/10.3390/membranes12121182

Paper A Microfluidic-Based Sensing Platform for Rapid Quality Control on Target Cells from Bioreactors

Alessia Foscarini; Fabio Romano; Valeria Garzarelli et al. · 2024 · Italian National Conference on Sensors · DOI

Full title: A Microfluidic-Based Sensing Platform for Rapid Quality Control on Target Cells from Bioreactors

Authors: Alessia Foscarini; Fabio Romano; Valeria Garzarelli; Antonio Turco; A. Bramanti; Iolena Tarantini; F. Ferrara; P. Visconti; Giuseppe Gigli; M. Chiriacò

Year: 2024

Venue: Italian National Conference on Sensors

DOI: https://doi.org/10.3390/s24227329

Paper The efficacy of third generation anti‑HER2 chimeric antigen receptor T�cells in combination with PD1 blockade against malignant glioblastoma cells

Shen, Luxi; Li, Hongzhi; Bin, Shufang et al. · 2019 · Oncology Reports · DOI

Full title: The efficacy of third generation anti‑HER2 chimeric antigen receptor T�cells in combination with PD1 blockade against malignant glioblastoma cells

Authors: Shen, Luxi; Li, Hongzhi; Bin, Shufang; Li, Panyuan; Chen, Jie; Gu, Haihua; Yuan, Weihua

Year: 2019

Venue: Oncology Reports

DOI: https://doi.org/10.3892/or.2019.7263

Paper Impact of serum-free media on the expansion and functionality of CD19.CAR T-cells

F. Eberhardt; Angela Hückelhoven-Krauss; Alexander Kunz et al. · 2023 · International Journal of Molecular Medicine · DOI

Full title: Impact of serum-free media on the expansion and functionality of CD19.CAR T-cells

Authors: F. Eberhardt; Angela Hückelhoven-Krauss; Alexander Kunz; Genqiao Jiang; T. Sauer; Avinoam Reichman; Brigitte Neuber; K. Böpple; A. Schmitt; C. Müller-Tidow; M. Schmitt; Anna Keib

Year: 2023

Venue: International Journal of Molecular Medicine

DOI: https://doi.org/10.3892/ijmm.2023.5261

Paper CAR-T CELL THERAPY FOR CHRONIC LYMPHOCYTIC LEUKEMIA: A PROMISING IMMUNOTHERAPY APPROACH

ZA Khan; T. Abaid; J. Khan et al. · 2024 · Biological and Clinical Sciences Research Journal · DOI

Full title: CAR-T CELL THERAPY FOR CHRONIC LYMPHOCYTIC LEUKEMIA: A PROMISING IMMUNOTHERAPY APPROACH

Authors: ZA Khan; T. Abaid; J. Khan; W. Ahmad; M. Usman; A. Babar; M. Naeem

Year: 2024

Venue: Biological and Clinical Sciences Research Journal

DOI: https://doi.org/10.54112/bcsrj.v2024i1.1378

Paper Genetically engineered T cells for cancer immunotherapy

Li, Dan; Li, Xue; Zhou, Weilin et al. · 2019 · Signal Transduction and Targeted Therapy · DOI

Full title: Genetically engineered T cells for cancer immunotherapy

Authors: Li, Dan; Li, Xue; Zhou, Weilin; Huang, Yong; Liang, Xiao; Lin, Jiang; Yang, Xiao; Sun, Jie; Li, Zonghai; Han, Weidong; Wang, Wei

Year: 2019

Venue: Signal Transduction and Targeted Therapy

DOI: https://doi.org/10.1038/s41392-019-0070-9

Paper The JAK/STAT signaling pathway: from bench to clinic

Hu, Xiaoyi; Li, Jing; Fu, Maorong et al. · 2021 · Signal Transduction and Targeted Therapy · DOI

Full title: The JAK/STAT signaling pathway: from bench to clinic

Authors: Hu, Xiaoyi; Li, Jing; Fu, Maorong; Zhao, Xia; Wang, Wei

Year: 2021

Venue: Signal Transduction and Targeted Therapy

DOI: https://doi.org/10.1038/s41392-021-00791-1

Paper NF-κB in biology and targeted therapy: new insights and translational implications

Guo, Qing; Jin, Yizi; Chen, Xinyu et al. · 2024 · Signal Transduction and Targeted Therapy · DOI

Full title: NF-κB in biology and targeted therapy: new insights and translational implications

Authors: Guo, Qing; Jin, Yizi; Chen, Xinyu; Ye, Xiaomin; Shen, Xin; Lin, Mingxi; Zeng, Cheng; Zhou, Teng; Zhang, Jian

Year: 2024

Venue: Signal Transduction and Targeted Therapy

DOI: https://doi.org/10.1038/s41392-024-01757-9

Paper γδ T cells: origin and fate, subsets, diseases and immunotherapy

Hu, Yi; Hu, Qinglin; Li, Yongsheng et al. · 2023 · Signal Transduction and Targeted Therapy · DOI

Full title: γδ T cells: origin and fate, subsets, diseases and immunotherapy

Authors: Hu, Yi; Hu, Qinglin; Li, Yongsheng; Lu, Ligong; Xiang, Zheng; Yin, Zhinan; Kabelitz, Dieter; Wu, Yangzhe

Year: 2023

Venue: Signal Transduction and Targeted Therapy

DOI: https://doi.org/10.1038/s41392-023-01653-8

Paper Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission

Zhiliang Bai; Bing Feng; Susan E. Mcclory et al. · 2024 · Nature · DOI

Full title: Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission

Authors: Zhiliang Bai; Bing Feng; Susan E. Mcclory; Beatriz Coutinho de Oliveira; C. Diorio; Céline Grégoire; Bo Tao; Luojia Yang; Ziran Zhao; Lei Peng; Giacomo Sferruzza; Liqun Zhou; Xiaolei Zhou; Jessica Kerr; Alev Baysoy; Graham Su; Mingyu Yang; Pablo G. Cámara; Sidi Chen; Li Tang; Carl H. June; J. Melenhorst; Stephan A. Grupp; Rong Fan

Year: 2024

Venue: Nature

DOI: https://doi.org/10.1038/s41586-024-07762-w

Paper PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function

Morotti, Matteo; Grimm, Alizée J; Hope, Helen Carrasco et al. · 2024 · Nature · DOI

Full title: PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function

Authors: Morotti, Matteo; Grimm, Alizée J; Hope, Helen Carrasco; Arnaud, Marion; Desbuisson, Mathieu; Rayroux, Nicolas; Barras, David; Masid, María; Murgues, Baptiste; Chap, Bovannak Stewen; Ongaro, Marco; Rota, Ioanna A.; Ronet, Catherine; Minasyan, Aspram; Chiffelle, Johanna; Lacher, Sebastian; Bobisse, Sara; Murgues, Clément; Ghisoni, Eleonora; Ouchen, Khaoula; Mjahed, Ribal Bou; Benedetti, Fabrizio; Abdellaoui, Naoill; Turrini, Riccardo; Gannon, Philippe O.; Zaman, Khalil; Mathevet, Patrice; Lelièvre, Loïc; Crespo, Isaac; Conrad, Marcus; Verdeil, Grégory; Kandalaft, Lana E.; Dagher, Julien; Corría-Osorio, Jesús; Doucey, Marie‐Agnès; Ho, Ping‐Chih; Harari, Alexandre; Vannini, Nicola; Böttcher, Jan P.; Laniti, Denarda Dangaj; Coukos, George

Year: 2024

Venue: Nature

DOI: https://doi.org/10.1038/s41586-024-07352-w

Paper FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

Chan, Jack D.; Scheffler, C.; Munoz, Isabelle et al. · 2024 · Nature · DOI

Full title: FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

Authors: Chan, Jack D.; Scheffler, C.; Munoz, Isabelle; Sek, Kevin; Lee, Joel N.; Huang, Yukuan; Yap, Kah Min; Saw, Nicole Y. L.; Li, Jasmine; Chen, Amanda X. Y.; Chan, Cheok Weng; Derrick, Emily B.; Todd, Kirsten L.; Tong, Junming; Dunbar, Phoebe; Li, Jiawen; Hoang, Thang X.; Menezes, Maria N. de; Petley, Emma V.; Kim, Joelle S.; Nguyen, Dat Quoc; Leung, P.; So, Joan; Deguit, Christian Deo T.; Zhu, Joe Jiang; House, Imran G.; Kats, Lev M.; Scott, Andrew M.; Solomon, Benjamin; Harrison, Simon J.; Oliaro, Jane; Parish, Ian A.; Quinn, Kylie M.; Neeson, Paul J.; Slaney, Clare Y.; Lai, Junyun; Beavis, Paul A.; Darcy, Phillip K.

Year: 2024

Venue: Nature

DOI: https://doi.org/10.1038/s41586-024-07242-1

Paper Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8+ T cells

Corría-Osorio, Jesús; Carmona, Santiago J.; Stefanidis, Evangelos et al. · 2023 · Nature Immunology · DOI

Full title: Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8+ T cells

Authors: Corría-Osorio, Jesús; Carmona, Santiago J.; Stefanidis, Evangelos; Andreatta, Massimo; Ortiz-Miranda, Yaquelin; Muller, Tania; Rota, Ioanna A.; Crespo, Isaac; Seijo, Bili; Castro, Wilson; Jiménez‐Luna, Cristina; Scarpellino, Léonardo; Ronet, Catherine; Spill, Aodrenn; Lanitis, Evripidis; Romero, Pedro; Luther, Sanjiv A.; Irving, Melita; Coukos, George

Year: 2023

Venue: Nature Immunology

DOI: https://doi.org/10.1038/s41590-023-01477-2

Paper Generation of allogeneic CAR-NKT cells from hematopoietic stem and progenitor cells using a clinically guided culture method

Yan-Ruide Li; Yang Zhou; Jiaji Yu et al. · 2024 · Nature Biotechnology · DOI

Full title: Generation of allogeneic CAR-NKT cells from hematopoietic stem and progenitor cells using a clinically guided culture method

Authors: Yan-Ruide Li; Yang Zhou; Jiaji Yu; Y. J. Kim; Miao Li; Derek Lee; Kuangyi Zhou; Yuning Chen; Yichen Zhu; Yu-Chen Wang; Zhe Li; Yanqi Yu; Z. Dunn; Wenbin Guo; Xin-Tang Cen; Tiffany Husman; Aarushi Bajpai; Adam Kramer; Matthew Wilson; Ying Fang; Jie Huang; Shuo Li; Yonggang Zhou; Yuchong Zhang; Zoe Hahn; Enbo Zhu; Feiyang Ma; Calvin Pan; A. Lusis; Jin J. Zhou; C. Seet; Donald B. Kohn; Pin Wang; X. Zhou; M. Pellegrini; Benjamin R. Puliafito; Sarah M Larson; Lili Yang

Year: 2024

Venue: Nature Biotechnology

DOI: https://doi.org/10.1038/s41587-024-02226-y

Paper Natural killer cells in cancer biology and therapy

Wu, Song‐Yang; Fu, Tong‐Ming; Jiang, Yi‐Zhou et al. · 2020 · Molecular Cancer · DOI

Full title: Natural killer cells in cancer biology and therapy

Authors: Wu, Song‐Yang; Fu, Tong‐Ming; Jiang, Yi‐Zhou; Shao, Zhi-Ming

Year: 2020

Venue: Molecular Cancer

DOI: https://doi.org/10.1186/s12943-020-01238-x

Paper CAR-T cell combination therapy: the next revolution in cancer treatment

Al‐Haideri, Maysoon; Tondok, Santalia Banne; Safa, Salar Hozhabri et al. · 2022 · Cancer Cell International · DOI

Full title: CAR-T cell combination therapy: the next revolution in cancer treatment

Authors: Al‐Haideri, Maysoon; Tondok, Santalia Banne; Safa, Salar Hozhabri; Maleki, Ali Heidarnejad; Rostami, Samaneh; Jalil, Abduladheem Turki; Al‐Gazally, Moaed E.; Alsaikhan, Fahad; Rizaev, Jasur; Mohammad, Talar Ahmad Merza; Tahmasebi, Safa

Year: 2022

Venue: Cancer Cell International

DOI: https://doi.org/10.1186/s12935-022-02778-6

Paper Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies

Muhammad, Shan; Fan, Tao; Hai, Yang et al. · 2023 · Molecular Cancer · DOI

Full title: Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies

Authors: Muhammad, Shan; Fan, Tao; Hai, Yang; Gao, Yibo; He, Jie

Year: 2023

Venue: Molecular Cancer

DOI: https://doi.org/10.1186/s12943-023-01826-7

Paper Lymphocyte expansion in bioreactors: upgrading adoptive cell therapy

García‐Aponte, Oscar Fabian; Herwig, Christoph; Kozma, Bence · 2021 · Journal of Biological Engineering · DOI

Full title: Lymphocyte expansion in bioreactors: upgrading adoptive cell therapy

Authors: García‐Aponte, Oscar Fabian; Herwig, Christoph; Kozma, Bence

Year: 2021

Venue: Journal of Biological Engineering

DOI: https://doi.org/10.1186/s13036-021-00264-7

Paper Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy

Yılmaz, Ahmet; Cui, Hanwei; Caligiuri, Michael A. et al. · 2020 · Journal of Hematology & Oncology · DOI

Full title: Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy

Authors: Yılmaz, Ahmet; Cui, Hanwei; Caligiuri, Michael A.; Yu, Jianhua

Year: 2020

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-020-00998-9

Paper Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy

Gong, Ying; Wolterink, Roel G. J. Klein; Wang, Jianxiang et al. · 2021 · Journal of Hematology & Oncology · DOI

Full title: Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy

Authors: Gong, Ying; Wolterink, Roel G. J. Klein; Wang, Jianxiang; Bos, Gerard M.J.; Germeraad, Wilfred T.V.

Year: 2021

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-021-01083-5

Paper Combination strategies to maximize the benefits of cancer immunotherapy

Zhu, Shaoming; Zhang, Tian; Zheng, Lei et al. · 2021 · Journal of Hematology & Oncology · DOI

Full title: Combination strategies to maximize the benefits of cancer immunotherapy

Authors: Zhu, Shaoming; Zhang, Tian; Zheng, Lei; Liu, Hongtao; Song, Wenru; Liu, Delong; Li, Zihai; Pan, Chong-xian

Year: 2021

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-021-01164-5

Paper Natural killer cells in clinical development as non-engineered, engineered, and combination therapies

Lamers-Kok, Nina; Panella, Denise; Georgoudaki, Anna‐Maria et al. · 2022 · Journal of Hematology & Oncology · DOI

Full title: Natural killer cells in clinical development as non-engineered, engineered, and combination therapies

Authors: Lamers-Kok, Nina; Panella, Denise; Georgoudaki, Anna‐Maria; Liu, Haiping; Özkazanç, Didem; Kučerová, Lucia; Duru, Adil Doganay; Spanholtz, Jan; Raimo, Monica

Year: 2022

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-022-01382-5

Paper Challenges and new technologies in adoptive cell therapy

Zhang, Pengchao; Zhang, Guizhong; Wan, Xiaochun · 2023 · Journal of Hematology & Oncology · DOI

Full title: Challenges and new technologies in adoptive cell therapy

Authors: Zhang, Pengchao; Zhang, Guizhong; Wan, Xiaochun

Year: 2023

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-023-01492-8

Paper Influence of Culture Conditions on Ex Vivo Expansion of T Lymphocytes and Their Function for Therapy: Current Insights and Open Questions

Sudarsanam, Harish; Buhmann, Raymund; Henschler, Reinhard · 2022 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Influence of Culture Conditions on Ex Vivo Expansion of T Lymphocytes and Their Function for Therapy: Current Insights and Open Questions

Authors: Sudarsanam, Harish; Buhmann, Raymund; Henschler, Reinhard

Year: 2022

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2022.886637

Paper Chimeric Antigen Receptor T-Cells: An Overview of Concepts, Applications, Limitations, and Proposed Solutions

Alnefaie, Alaa; Albogami, Sarah; Asiri, Yousif A. et al. · 2022 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Chimeric Antigen Receptor T-Cells: An Overview of Concepts, Applications, Limitations, and Proposed Solutions

Authors: Alnefaie, Alaa; Albogami, Sarah; Asiri, Yousif A.; Ahmad, Tanveer; Alotaibi, Saqer S.; Al‐Sanea, Mohammad M.; Althobaiti, Hisham

Year: 2022

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2022.797440

Paper Revving up Natural Killer Cells and Cytokine-Induced Killer Cells Against Hematological Malignancies

Pittari, Gianfranco; Filippini, Perla; Gentilcore, Giusy et al. · 2015 · Frontiers in Immunology · DOI

Full title: Revving up Natural Killer Cells and Cytokine-Induced Killer Cells Against Hematological Malignancies

Authors: Pittari, Gianfranco; Filippini, Perla; Gentilcore, Giusy; Grivel, Jean‐Charles; Rutella, Sergio

Year: 2015

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2015.00230

Paper Natural Killer Cells: Development, Maturation, and Clinical Utilization

Abel, Alex; Yang, Chao; Thakar, Monica S. et al. · 2018 · Frontiers in Immunology · DOI

Full title: Natural Killer Cells: Development, Maturation, and Clinical Utilization

Authors: Abel, Alex; Yang, Chao; Thakar, Monica S.; Malarkannan, Subramaniam

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.01869

Paper CAR T Cells for Solid Tumors: New Strategies for Finding, Infiltrating, and Surviving in the Tumor Microenvironment

Martinez, Marina C.; Moon, Edmund K. · 2019 · Frontiers in Immunology · DOI

Full title: CAR T Cells for Solid Tumors: New Strategies for Finding, Infiltrating, and Surviving in the Tumor Microenvironment

Authors: Martinez, Marina C.; Moon, Edmund K.

Year: 2019

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2019.00128

Paper TCR Redirected T Cells for Cancer Treatment: Achievements, Hurdles, and Goals

Manfredi, Francesco; Cianciotti, Beatrice Claudia; Potenza, Alessia et al. · 2020 · Frontiers in Immunology · DOI

Full title: TCR Redirected T Cells for Cancer Treatment: Achievements, Hurdles, and Goals

Authors: Manfredi, Francesco; Cianciotti, Beatrice Claudia; Potenza, Alessia; Tassi, Elena; Noviello, Maddalena; Biondi, Andrea; Ciceri, Fabio; Bonini, Chiara; Ruggiero, Eliana

Year: 2020

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2020.01689

Paper Localized Interleukin-12 for Cancer Immunotherapy

Nguyen, Khue G.; Vrabel, Maura R.; Mantooth, Siena M. et al. · 2020 · Frontiers in Immunology · DOI

Full title: Localized Interleukin-12 for Cancer Immunotherapy

Authors: Nguyen, Khue G.; Vrabel, Maura R.; Mantooth, Siena M.; Hopkins, Jared; Wagner, Ethan S.; Gabaldon, Taylor A.; Zaharoff, David A.

Year: 2020

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2020.575597

Paper CAR-NK Cells: From Natural Basis to Design for Kill

Khawar, Muhammad Babar; Sun, Haibo · 2021 · Frontiers in Immunology · DOI

Full title: CAR-NK Cells: From Natural Basis to Design for Kill

Authors: Khawar, Muhammad Babar; Sun, Haibo

Year: 2021

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2021.707542

Paper Tumor-infiltrating lymphocytes for treatment of solid tumors: It takes two to tango?

Kazemi, Mohammad; Sadri, Maryam; Najafi, Alireza et al. · 2022 · Frontiers in Immunology · DOI

Full title: Tumor-infiltrating lymphocytes for treatment of solid tumors: It takes two to tango?

Authors: Kazemi, Mohammad; Sadri, Maryam; Najafi, Alireza; Rahimi, Ali; Baghernejadan, Zeinab; Khorramdelazad, Hossein; Falak, Reza

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.1018962

Paper Emerging Strategies in TCR-Engineered T Cells

Fang, Wei; Cheng, Xiaoxia; Xue, John Z. et al. · 2022 · Frontiers in Immunology · DOI

Full title: Emerging Strategies in TCR-Engineered T Cells

Authors: Fang, Wei; Cheng, Xiaoxia; Xue, John Z.; Xue, Shao‐An

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.850358

Paper Recent Advances in Solid Tumor CAR-T Cell Therapy: Driving Tumor Cells From Hero to Zero?

Kozani, Pouya Safarzadeh; Kozani, Pooria Safarzadeh; Najafabadi, Milad Ahmadi et al. · 2022 · Frontiers in Immunology · DOI

Full title: Recent Advances in Solid Tumor CAR-T Cell Therapy: Driving Tumor Cells From Hero to Zero?

Authors: Kozani, Pouya Safarzadeh; Kozani, Pooria Safarzadeh; Najafabadi, Milad Ahmadi; Yousefi, Fatemeh; Mirarefin, Seyed Mohamad Javad; Rahbarizadeh, Fatemeh

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.795164

Paper Advances in CAR-T Cell Genetic Engineering Strategies to Overcome Hurdles in Solid Tumors Treatment

Andrea, Alain E.; Chiron, Andrada; Mallah, Sarah et al. · 2022 · Frontiers in Immunology · DOI

Full title: Advances in CAR-T Cell Genetic Engineering Strategies to Overcome Hurdles in Solid Tumors Treatment

Authors: Andrea, Alain E.; Chiron, Andrada; Mallah, Sarah; Bessoles, Stéphanie; Sarrabayrouse, Guillaume; Hacein‐Bey‐Abina, Salima

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.830292

Paper CAR-T Cell Therapy in Hematological Malignancies: Current Opportunities and Challenges

Zhang, Xiaomin; Zhu, Lingling; Zhang, Hui et al. · 2022 · Frontiers in Immunology · DOI

Full title: CAR-T Cell Therapy in Hematological Malignancies: Current Opportunities and Challenges

Authors: Zhang, Xiaomin; Zhu, Lingling; Zhang, Hui; Chen, Shanshan; Xiao, Yang

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.927153

Paper Overcoming tumor resistance mechanisms in CAR-NK cell therapy

A. Valeri; A. García-Ortiz; E. Castellano et al. · 2022 · Frontiers in Immunology · DOI

Full title: Overcoming tumor resistance mechanisms in CAR-NK cell therapy

Authors: A. Valeri; A. García-Ortiz; E. Castellano; L. Córdoba; E. Maroto-Martín; J. Encinas; A. Leivas; P. Río; J. Martínez-López

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.953849

Paper Understanding NK cell biology for harnessing NK cell therapies: targeting cancer and beyond

Shin, Eunju; Bak, Seong Ho; Park, Tae‐Ho et al. · 2023 · Frontiers in Immunology · DOI

Full title: Understanding NK cell biology for harnessing NK cell therapies: targeting cancer and beyond

Authors: Shin, Eunju; Bak, Seong Ho; Park, Tae‐Ho; Kim, Jin-Woo; Yoon, Suk-Ran; Jung, Haiyoung; Noh, Ji‐Yoon

Year: 2023

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2023.1192907

Paper Cell Therapy: Types, Regulation, and Clinical Benefits

El-Kadiry, Abed El-Hakim; Rafei, Moutih; Shammaa, Riam · 2021 · Frontiers in Medicine · DOI

Full title: Cell Therapy: Types, Regulation, and Clinical Benefits

Authors: El-Kadiry, Abed El-Hakim; Rafei, Moutih; Shammaa, Riam

Year: 2021

Venue: Frontiers in Medicine

DOI: https://doi.org/10.3389/fmed.2021.756029

Paper Metabolic reprogramming of CAR T cells: a new frontier in cancer immunotherapy

Tjaša Frlic; Mojca Pavlin · 2025 · Frontiers in Immunology · DOI

Full title: Metabolic reprogramming of CAR T cells: a new frontier in cancer immunotherapy

Authors: Tjaša Frlic; Mojca Pavlin

Year: 2025

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2025.1688995

Paper Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy

Gupta, Seema; Roy, Amrita; Dwarakanath, Bilikere S. · 2017 · Frontiers in Oncology · DOI

Full title: Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy

Authors: Gupta, Seema; Roy, Amrita; Dwarakanath, Bilikere S.

Year: 2017

Venue: Frontiers in Oncology

DOI: https://doi.org/10.3389/fonc.2017.00068

Paper Overcoming Resistance to Natural Killer Cell Based Immunotherapies for Solid Tumors

Nayyar, Gaurav; Chu, Yaya; Cairo, Mitchell S. · 2019 · Frontiers in Oncology · DOI

Full title: Overcoming Resistance to Natural Killer Cell Based Immunotherapies for Solid Tumors

Authors: Nayyar, Gaurav; Chu, Yaya; Cairo, Mitchell S.

Year: 2019

Venue: Frontiers in Oncology

DOI: https://doi.org/10.3389/fonc.2019.00051

Paper Advances in chimeric antigen receptor-natural killer cell therapy: from mechanisms and preclinical studies to clinical application

Tianyuan Ren; Fengjiang Wang; Xuan Liu et al. · 2026 · Frontiers in Oncology · DOI

Full title: Advances in chimeric antigen receptor-natural killer cell therapy: from mechanisms and preclinical studies to clinical application

Authors: Tianyuan Ren; Fengjiang Wang; Xuan Liu; Jun Guo; Sitan Xie

Year: 2026

Venue: Frontiers in Oncology

DOI: https://doi.org/10.3389/fonc.2025.1759796

Paper Mitochondria at Work: New Insights into Regulation and Dysregulation of Cellular Energy Supply and Metabolism

Schirrmacher, Volker · 2020 · Biomedicines · DOI

Full title: Mitochondria at Work: New Insights into Regulation and Dysregulation of Cellular Energy Supply and Metabolism

Authors: Schirrmacher, Volker

Year: 2020

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines8110526

Paper FDA-Approved Drugs for Hematological Malignancies—The Last Decade Review

Sochacka-Ćwikła, Aleksandra; Mą̨czyński, Marcin; Regiec, Andrzej · 2021 · Cancers · DOI

Full title: FDA-Approved Drugs for Hematological Malignancies—The Last Decade Review

Authors: Sochacka-Ćwikła, Aleksandra; Mą̨czyński, Marcin; Regiec, Andrzej

Year: 2021

Venue: Cancers

DOI: https://doi.org/10.3390/cancers14010087

Paper Fine-Tuning through Generations: Advances in Structure and Production of CAR-T Therapy

Zheng, Zhibo; Li, Siyuan; Liu, Mohan et al. · 2023 · Cancers · DOI

Full title: Fine-Tuning through Generations: Advances in Structure and Production of CAR-T Therapy

Authors: Zheng, Zhibo; Li, Siyuan; Liu, Mohan; Chen, Chuyan; Zhang, Lu; Zhou, Daobin

Year: 2023

Venue: Cancers

DOI: https://doi.org/10.3390/cancers15133476

Paper Fluid shear stress enhances T cell activation through Piezo1

Hope, Jacob M.; Dombroski, Jenna A.; Pereles, Rebecca S. et al. · 2022 · BMC Biology · DOI

Full title: Fluid shear stress enhances T cell activation through Piezo1

Authors: Hope, Jacob M.; Dombroski, Jenna A.; Pereles, Rebecca S.; Lopez‐Cavestany, Maria; Greenlee, Joshua D.; Schwager, Samantha C.; Reinhart‐King, Cynthia A.; King, Michael R.

Year: 2022

Venue: BMC Biology

DOI: https://doi.org/10.1186/s12915-022-01266-7

Paper Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects

Shi, Huan; Sun, Meili; Liu, Lin et al. · 2014 · Molecular Cancer · DOI

Full title: Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects

Authors: Shi, Huan; Sun, Meili; Liu, Lin; Wang, Zhehai

Year: 2014

Venue: Molecular Cancer

DOI: https://doi.org/10.1186/1476-4598-13-219

Paper Optimizing interleukin-2 concentration, seeding density and bead-to-cell ratio of T-cell expansion for adoptive immunotherapy

Ghaffari, Sasan; Torabi‐Rahvar, Monireh; Aghayan, Sajjad et al. · 2021 · BMC Immunology · DOI

Full title: Optimizing interleukin-2 concentration, seeding density and bead-to-cell ratio of T-cell expansion for adoptive immunotherapy

Authors: Ghaffari, Sasan; Torabi‐Rahvar, Monireh; Aghayan, Sajjad; Jabbarpour, Zahra; Moradzadeh, Kobra; Omidkhoda, Azadeh; Ahmadbeigi, Naser

Year: 2021

Venue: BMC Immunology

DOI: https://doi.org/10.1186/s12865-021-00435-7

Paper CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing

Andersch, Lena; Radke, Josefine; Klaus, Anika et al. · 2019 · BMC Cancer · DOI

Full title: CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing

Authors: Andersch, Lena; Radke, Josefine; Klaus, Anika; Schwiebert, Silke; Winkler, Annika; Schumann, Elisa; Grunewald, Laura; Zirngibl, Felix; Flemmig, Carina; Jensen, Michael C.; Rössig, Claudia; Joussen, Antonia M.; Henssen, Anton G.; Eggert, Angelika; Schulte, Johannes H.; Künkele, Annette

Year: 2019

Venue: BMC Cancer

DOI: https://doi.org/10.1186/s12885-019-6131-1

Paper Tumor-related interleukins: old validated targets for new anti-cancer drug development

Setrerrahmane, Sarra; Xu, Hanmei · 2017 · Molecular Cancer · DOI

Full title: Tumor-related interleukins: old validated targets for new anti-cancer drug development

Authors: Setrerrahmane, Sarra; Xu, Hanmei

Year: 2017

Venue: Molecular Cancer

DOI: https://doi.org/10.1186/s12943-017-0721-9

Paper Challenges of driving CD30-directed CAR-T cells to the clinic

Grover, Natalie S.; Savoldo, Barbara · 2019 · BMC Cancer · DOI

Full title: Challenges of driving CD30-directed CAR-T cells to the clinic

Authors: Grover, Natalie S.; Savoldo, Barbara

Year: 2019

Venue: BMC Cancer

DOI: https://doi.org/10.1186/s12885-019-5415-9

Paper CAR-NKT cell therapy: a new promising paradigm of cancer immunotherapy

Hadiloo, Kaveh; Tahmasebi, Safa; Esmaeilzadeh, Abdolreza · 2023 · Cancer Cell International · DOI

Full title: CAR-NKT cell therapy: a new promising paradigm of cancer immunotherapy

Authors: Hadiloo, Kaveh; Tahmasebi, Safa; Esmaeilzadeh, Abdolreza

Year: 2023

Venue: Cancer Cell International

DOI: https://doi.org/10.1186/s12935-023-02923-9

Paper The reciprocal regulation between host tissue and immune cells in pancreatic ductal adenocarcinoma: new insights and therapeutic implications

Liu, Xiaomeng; Xu, Jin; Zhang, Bo et al. · 2019 · Molecular Cancer · DOI

Full title: The reciprocal regulation between host tissue and immune cells in pancreatic ductal adenocarcinoma: new insights and therapeutic implications

Authors: Liu, Xiaomeng; Xu, Jin; Zhang, Bo; Liu, Jiang; Liang, Chen; Meng, Qingcai; Hua, Jie; Yu, Xianjun; Shi, Si

Year: 2019

Venue: Molecular Cancer

DOI: https://doi.org/10.1186/s12943-019-1117-9

Paper Targeting the RNA m6A modification for cancer immunotherapy

Li, Xinxin; Ma, Shoubao; Deng, Youcai et al. · 2022 · Molecular Cancer · DOI

Full title: Targeting the RNA m6A modification for cancer immunotherapy

Authors: Li, Xinxin; Ma, Shoubao; Deng, Youcai; Yi, Ping; Yu, Jianhua

Year: 2022

Venue: Molecular Cancer

DOI: https://doi.org/10.1186/s12943-022-01558-0

Paper The journey of CAR-T therapy in hematological malignancies

Lu, Junru; Jiang, Guan · 2022 · Molecular Cancer · DOI

Full title: The journey of CAR-T therapy in hematological malignancies

Authors: Lu, Junru; Jiang, Guan

Year: 2022

Venue: Molecular Cancer

DOI: https://doi.org/10.1186/s12943-022-01663-0

Paper NK cells and solid tumors: therapeutic potential and persisting obstacles

Tong, Le; Jiménez‐Cortegana, Carlos; Tay, Apple H.M. et al. · 2022 · Molecular Cancer · DOI

Full title: NK cells and solid tumors: therapeutic potential and persisting obstacles

Authors: Tong, Le; Jiménez‐Cortegana, Carlos; Tay, Apple H.M.; Wickström, Stina L.; Galluzzi, Lorenzo; Lundqvist, Andreas

Year: 2022

Venue: Molecular Cancer

DOI: https://doi.org/10.1186/s12943-022-01672-z

Paper Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing

Dimitri, Alexander J.; Herbst, Friederike; Fraietta, Joseph A. · 2022 · Molecular Cancer · DOI

Full title: Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing

Authors: Dimitri, Alexander J.; Herbst, Friederike; Fraietta, Joseph A.

Year: 2022

Venue: Molecular Cancer

DOI: https://doi.org/10.1186/s12943-022-01559-z

Paper Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells

D. Stroncek; Daniel W. Lee; Jiaqiang Ren et al. · 2017 · Journal of Translational Medicine · DOI

Full title: Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells

Authors: D. Stroncek; Daniel W. Lee; Jiaqiang Ren; M. Sabatino; S. Highfill; H. Khuu; N. Shah; R. Kaplan; T. Fry; C. Mackall

Year: 2017

Venue: Journal of Translational Medicine

DOI: https://doi.org/10.1186/s12967-017-1160-5

Paper Optimization of metabolism to improve efficacy during CAR-T cell manufacturing

Zhang, Meng; Jin, Xin; Sun, Rui et al. · 2021 · Journal of Translational Medicine · DOI

Full title: Optimization of metabolism to improve efficacy during CAR-T cell manufacturing

Authors: Zhang, Meng; Jin, Xin; Sun, Rui; Xiong, Xia; Wang, Jiaxi; Xie, Danni; Zhao, Mingfeng

Year: 2021

Venue: Journal of Translational Medicine

DOI: https://doi.org/10.1186/s12967-021-03165-x

Paper A phase I clinical trial of adoptive T cell therapy using IL-12 secreting MUC-16ecto directed chimeric antigen receptors for recurrent ovarian cancer

Koneru, Mythili; O’Cearbhaill, Roisin E.; Pendharkar, Swati et al. · 2015 · Journal of Translational Medicine · DOI

Full title: A phase I clinical trial of adoptive T cell therapy using IL-12 secreting MUC-16ecto directed chimeric antigen receptors for recurrent ovarian cancer

Authors: Koneru, Mythili; O’Cearbhaill, Roisin E.; Pendharkar, Swati; Spriggs, David R.; Brentjens, Renier J.

Year: 2015

Venue: Journal of Translational Medicine

DOI: https://doi.org/10.1186/s12967-015-0460-x

Paper Evolution of cell therapy for renal cell carcinoma

Wang, Yufei; Suarez, Eloah Rabello; Kastrunes, Gabriella et al. · 2024 · Molecular Cancer · DOI

Full title: Evolution of cell therapy for renal cell carcinoma

Authors: Wang, Yufei; Suarez, Eloah Rabello; Kastrunes, Gabriella; Campos, Najla Santos Pacheco de; Abbas, Rabia; Pivetta, Renata Schmieder; Murugan, Nithyassree; Chalbatani, Ghanbar Mahmoodi; D’Andrea, Vincent; Marasco, Wayne A.

Year: 2024

Venue: Molecular Cancer

DOI: https://doi.org/10.1186/s12943-023-01911-x

Paper Metabolic reprogramming through PIM3 inhibition reverses hypoxia-induced CAR-T cell dysfunction in solid tumors

Muya Zhou; Luxia Xu; Jinhua Hu et al. · 2025 · Journal of Translational Medicine · DOI

Full title: Metabolic reprogramming through PIM3 inhibition reverses hypoxia-induced CAR-T cell dysfunction in solid tumors

Authors: Muya Zhou; Luxia Xu; Jinhua Hu; Wenwen Chen; Jialu Hong; Mufeng Wang; Zhi-Cheng Guo

Year: 2025

Venue: Journal of Translational Medicine

DOI: https://doi.org/10.1186/s12967-025-07278-5

Paper Co-expression IL-15 receptor alpha with IL-15 reduces toxicity via limiting IL-15 systemic exposure during CAR-T immunotherapy

Zhang, Ying; Zhuang, Qinghui; Wang, Fang et al. · 2022 · Journal of Translational Medicine · DOI

Full title: Co-expression IL-15 receptor alpha with IL-15 reduces toxicity via limiting IL-15 systemic exposure during CAR-T immunotherapy

Authors: Zhang, Ying; Zhuang, Qinghui; Wang, Fang; Zhang, Can; Xu, Chang; Gu, Aiqin; Zhong, William H.; Hu, Yi; Zhong, Xiaosong

Year: 2022

Venue: Journal of Translational Medicine

DOI: https://doi.org/10.1186/s12967-022-03626-x

Paper Deciphering the importance of culture pH on CD22 CAR T-cells characteristics

M. Procházková; Alexandra Dreyzin; L. Shao et al. · 2024 · Journal of Translational Medicine · DOI

Full title: Deciphering the importance of culture pH on CD22 CAR T-cells characteristics

Authors: M. Procházková; Alexandra Dreyzin; L. Shao; Pam Garces; Yihua Cai; Rongye Shi; Alejandra Pelayo; Yong Soo Kim; Victoria Pham; S. Frodigh; Shannon Fenton; Catherine Karangwa; Yan Su; Kathryn Martin; Nan Zhang; S. Highfill; R. Somerville; Nirali N. Shah; David F. Stroncek; Ping Jin

Year: 2024

Venue: Journal of Translational Medicine

DOI: https://doi.org/10.1186/s12967-024-05197-5

Paper Exhaustion of CAR T cells: potential causes and solutions

Kouro, Taku; Himuro, Hidetomo; Sasada, Tetsuro · 2022 · Journal of Translational Medicine · DOI

Full title: Exhaustion of CAR T cells: potential causes and solutions

Authors: Kouro, Taku; Himuro, Hidetomo; Sasada, Tetsuro

Year: 2022

Venue: Journal of Translational Medicine

DOI: https://doi.org/10.1186/s12967-022-03442-3

Paper From ex vivo to in vivo chimeric antigen T cells manufacturing: new horizons for CAR T-cell based therapy

E. Pinto; L. Lione; M. Compagnone et al. · 2025 · Journal of Translational Medicine · DOI

Full title: From ex vivo to in vivo chimeric antigen T cells manufacturing: new horizons for CAR T-cell based therapy

Authors: E. Pinto; L. Lione; M. Compagnone; M. Paccagnella; E. Salvatori; M. Greco; V. Frezza; E. Marra; L. Aurisicchio; G. Roscilli; A. Conforti

Year: 2025

Venue: Journal of Translational Medicine

DOI: https://doi.org/10.1186/s12967-024-06052-3

Paper Rapidly-manufactured CD276 CAR-T cells exhibit enhanced persistence and efficacy in pancreatic cancer

Tian Deng; Yingzhi Deng; Shih-Ting Tsao et al. · 2024 · Journal of Translational Medicine · DOI

Full title: Rapidly-manufactured CD276 CAR-T cells exhibit enhanced persistence and efficacy in pancreatic cancer

Authors: Tian Deng; Yingzhi Deng; Shih-Ting Tsao; Qinghui Xiong; Yue Yao; Cuicui Liu; Mingyuan Gu; Fei Huang; Haiying Wang

Year: 2024

Venue: Journal of Translational Medicine

DOI: https://doi.org/10.1186/s12967-024-05462-7

Paper Efficacy and safety of CAR-T therapy targeting CLL1 in patients with extramedullary diseases of acute myeloid leukemia

Yifan Zhao; Xue Bai; Shujing Guo et al. · 2024 · Journal of Translational Medicine · DOI

Full title: Efficacy and safety of CAR-T therapy targeting CLL1 in patients with extramedullary diseases of acute myeloid leukemia

Authors: Yifan Zhao; Xue Bai; Shujing Guo; Xiaomei Zhang; Jile Liu; Mohan Zhao; Tianle Xie; Haotian Meng; Yu Zhang; Xiaoyuan He; Mingfeng Zhao

Year: 2024

Venue: Journal of Translational Medicine

DOI: https://doi.org/10.1186/s12967-024-05705-7

Paper Natural killer cells: a promising immunotherapy for cancer

J. Chu; F. Gao; Mei-hua Yan et al. · 2022 · Journal of Translational Medicine · DOI

Full title: Natural killer cells: a promising immunotherapy for cancer

Authors: J. Chu; F. Gao; Mei-hua Yan; Shuang Zhao; Zheng Yan; B. Shi; Yanyan Liu

Year: 2022

Venue: Journal of Translational Medicine

DOI: https://doi.org/10.1186/s12967-022-03437-0

Paper Cancer immunotherapy beyond immune checkpoint inhibitors

Marin‐Acevedo, Julian A.; Soyano, Aixa; Dholaria, Bhagirathbhai et al. · 2018 · Journal of Hematology & Oncology · DOI

Full title: Cancer immunotherapy beyond immune checkpoint inhibitors

Authors: Marin‐Acevedo, Julian A.; Soyano, Aixa; Dholaria, Bhagirathbhai; Knutson, Keith L.; Lou, Yanyan

Year: 2018

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-017-0552-6

Paper Bispecific CAR-T cells targeting both CD19 and CD22 for therapy of adults with relapsed or refractory B cell acute lymphoblastic leukemia

Dai, Hanren; Wu, Zhiqiang; Jia, Hejin et al. · 2020 · Journal of Hematology & Oncology · DOI

Full title: Bispecific CAR-T cells targeting both CD19 and CD22 for therapy of adults with relapsed or refractory B cell acute lymphoblastic leukemia

Authors: Dai, Hanren; Wu, Zhiqiang; Jia, Hejin; Tong, Chuan; Guo, Yelei; Ti, Dongdong; Xiao, Han; Liu, Yang; Zhang, Wenying; Wang, Chunmeng; Han, Weidong; Chen, Meixia; Yang, Qingming; Wang, Yao; Han, Weidong

Year: 2020

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-020-00856-8

Paper The synergistic and enhancive effects of IL-6 and M-CSF to expand and differentiate functional dendritic cells from human monocytes under serum-free condition

Chao-Ling Yao; Tsung-Yu Tseng · 2023 · Journal of Biological Engineering · DOI

Full title: The synergistic and enhancive effects of IL-6 and M-CSF to expand and differentiate functional dendritic cells from human monocytes under serum-free condition

Authors: Chao-Ling Yao; Tsung-Yu Tseng

Year: 2023

Venue: Journal of Biological Engineering

DOI: https://doi.org/10.1186/s13036-023-00325-z

Paper Mechanisms and rejuvenation strategies for aged hematopoietic stem cells

Li, Xia; Zeng, Xiangjun; Xu, Yulin et al. · 2020 · Journal of Hematology & Oncology · DOI

Full title: Mechanisms and rejuvenation strategies for aged hematopoietic stem cells

Authors: Li, Xia; Zeng, Xiangjun; Xu, Yulin; Wang, Binsheng; Zhao, Yanmin; Lai, Xiaoyu; Qian, Pengxu; Huang, He

Year: 2020

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-020-00864-8

Paper Gene modification strategies for next-generation CAR T cells against solid cancers

Tian, Yonggui; Li, Yilu; Shao, Yupei et al. · 2020 · Journal of Hematology & Oncology · DOI

Full title: Gene modification strategies for next-generation CAR T cells against solid cancers

Authors: Tian, Yonggui; Li, Yilu; Shao, Yupei; Zhang, Yi

Year: 2020

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-020-00890-6

Paper Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells

Qin, Le; Lai, Yunxin; Zhao, Ruocong et al. · 2017 · Journal of Hematology & Oncology · DOI

Full title: Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells

Authors: Qin, Le; Lai, Yunxin; Zhao, Ruocong; Wei, Xinru; Weng, Jianyu; Lai, Peilong; Li, Baiheng; Lin, Simiao; Wang, Suna; Wu, Qiting; Liang, Qiubin; Li, Yangqiu; Zhang, Xuchao; Wu, Yi‐Long; Liu, Pentao; Yao, Yao; Pei, Duanqing; Du, Xin; Li, Peng

Year: 2017

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-017-0437-8

Paper Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward

Li, Jian; Li, Wenwen; Huang, Kejia et al. · 2018 · Journal of Hematology & Oncology · DOI

Full title: Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward

Authors: Li, Jian; Li, Wenwen; Huang, Kejia; Zhang, Yang; Kupfer, Gary M.; Zhao, Qi

Year: 2018

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-018-0568-6

Paper Efficacy and safety of CD19 CAR T constructed with a new anti-CD19 chimeric antigen receptor in relapsed or refractory acute lymphoblastic leukemia

Gu, Runxia; Liu, Fang; Zou, Dehui et al. · 2020 · Journal of Hematology & Oncology · DOI

Full title: Efficacy and safety of CD19 CAR T constructed with a new anti-CD19 chimeric antigen receptor in relapsed or refractory acute lymphoblastic leukemia

Authors: Gu, Runxia; Liu, Fang; Zou, Dehui; Xu, Yingxi; Yang, Lu; Liu, Bingcheng; Liu, Wei; Chen, Xiaojuan; Liu, Kaiqi; Guo, Ye; Gong, Xiaoyuan; Lv, Rui; Chen, Xia; Zhou, Chunlin; Zhong, Mengjun; Wang, Huijun; Wei, Hui; Mi, Yingchang; Qiu, Lugui; Lv, Lulu; Wang, Min; Wang, Ying; Zhu, Xiaofan; Wang, Jianxiang

Year: 2020

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-020-00953-8

Paper NK cell-based cancer immunotherapy: from basic biology to clinical development

Liu, Sizhe; Galat, Vasiliy; Galat, Yekaterina et al. · 2021 · Journal of Hematology & Oncology · DOI

Full title: NK cell-based cancer immunotherapy: from basic biology to clinical development

Authors: Liu, Sizhe; Galat, Vasiliy; Galat, Yekaterina; Lee, Yoo Kyung Annie; Wainwright, Derek A.; Wu, Jennifer D.

Year: 2021

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-020-01014-w

Paper Delivery strategies of cancer immunotherapy: recent advances and future perspectives

Zhao, Zhongwei; Zheng, Liyun; Chen, Weiqian et al. · 2019 · Journal of Hematology & Oncology · DOI

Full title: Delivery strategies of cancer immunotherapy: recent advances and future perspectives

Authors: Zhao, Zhongwei; Zheng, Liyun; Chen, Weiqian; Weng, Wei; Song, Jingjing; Ji, Jiansong

Year: 2019

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-019-0817-3

Paper A bispecific CAR-T cell therapy targeting BCMA and CD38 in relapsed or refractory multiple myeloma

Mei, Heng; Li, Chenggong; Jiang, Huiwen et al. · 2021 · Journal of Hematology & Oncology · DOI

Full title: A bispecific CAR-T cell therapy targeting BCMA and CD38 in relapsed or refractory multiple myeloma

Authors: Mei, Heng; Li, Chenggong; Jiang, Huiwen; Zhao, Xinying; Huang, Zhiping; Jin, Dan; Guo, Tao; Kou, Haiming; Liu, Lin; Tang, Lu; Yin, Ping; Wang, Zhihui; Ai, Lisha; Sha, Ke; Xia, Yimeng; Deng, Jun; Chen, Lei; Cai, Li; Sun, Chunyan; Xia, Linghui; Hua, Gaoquan; Hu, Yu

Year: 2021

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-021-01170-7

Paper Treatment of adult ALL patients with third-generation CD19-directed CAR T cells: results of a pivotal trial

M. Schubert; A. Schmitt; Angela Hückelhoven-Krauss et al. · 2023 · Journal of Hematology & Oncology · DOI

Full title: Treatment of adult ALL patients with third-generation CD19-directed CAR T cells: results of a pivotal trial

Authors: M. Schubert; A. Schmitt; Angela Hückelhoven-Krauss; Brigitte Neuber; Alexander Kunz; Philipp Waldhoff; Dominik Vonficht; S. Yousefian; L. Jopp-Saile; Lei Wang; Felix Korell; Anna Keib; Birgit Michels; Dominik Haas; T. Sauer; P. Derigs; A. Kulozik; J. Kunz; P. Pavel; Sascha Laier; P. Wuchter; J. Schmier; G. Bug; F. Lang; N. Gökbuget; J. Casper; M. Görner; J. Finke; A. Neubauer; M. Ringhoffer; D. Wolleschak; M. Brüggemann; S. Haas; A. D. Ho; C. Müller-Tidow; P. Dreger; M. Schmitt

Year: 2023

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-023-01470-0

Paper Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells

Huang, Yue; Si, Xiaohui; Shao, Mi et al. · 2022 · Journal of Hematology & Oncology · DOI

Full title: Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells

Authors: Huang, Yue; Si, Xiaohui; Shao, Mi; Teng, Xinyi; Xiao, Gang; Huang, He

Year: 2022

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-022-01255-x

Paper Safe and effective off-the-shelf immunotherapy based on CAR.CD123-NK cells for the treatment of acute myeloid leukaemia

Caruso, Simona; Angelis, Biagio De; Bufalo, Francesca Del et al. · 2022 · Journal of Hematology & Oncology · DOI

Full title: Safe and effective off-the-shelf immunotherapy based on CAR.CD123-NK cells for the treatment of acute myeloid leukaemia

Authors: Caruso, Simona; Angelis, Biagio De; Bufalo, Francesca Del; Ciccone, Roselia; Donsante, Samantha; Volpe, Gabriele; Manni, Simona; Guercio, Marika; Pezzella, Michele; Iaffaldano, Laura; Silvestris, Domenico Alessandro; Sinibaldi, Matilde; Cecca, Stefano Di; Pitisci, Angela; Velardi, Enrico; Merli, Pietro; Algeri, Mattia; Lodi, Mariachiara; Paganelli, Valeria; Serafini, Marta; Riminucci, Mara; Locatelli, Franco; Quintarelli, Concetta

Year: 2022

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-022-01376-3

Paper Deciphering mechanisms of immune escape to inform immunotherapeutic strategies in multiple myeloma

Swamydas, Muthulekha; Murphy, Elena V.; Ignatz-Hoover, James J. et al. · 2022 · Journal of Hematology & Oncology · DOI

Full title: Deciphering mechanisms of immune escape to inform immunotherapeutic strategies in multiple myeloma

Authors: Swamydas, Muthulekha; Murphy, Elena V.; Ignatz-Hoover, James J.; Malek, Ehsan; Driscoll, James J.

Year: 2022

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-022-01234-2

Paper Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy

Bulliard, Yannick; Andersson, Börje S.; Baysal, Mehmet A. et al. · 2023 · Journal of Hematology & Oncology · DOI

Full title: Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy

Authors: Bulliard, Yannick; Andersson, Börje S.; Baysal, Mehmet A.; Damiano, Jason S.; Tsimberidou, Apostolia M.

Year: 2023

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-023-01504-7

Paper Anti-CD166/4-1BB chimeric antigen receptor T cell therapy for the treatment of osteosarcoma

Wang, Yitian; Yu, Wei; Zhu, Jian et al. · 2019 · Journal of Experimental & Clinical Cancer Research · DOI

Full title: Anti-CD166/4-1BB chimeric antigen receptor T cell therapy for the treatment of osteosarcoma

Authors: Wang, Yitian; Yu, Wei; Zhu, Jian; Wang, Junjie; Xia, Kaishun; Liang, Chengzhen; Tao, Huimin

Year: 2019

Venue: Journal of Experimental & Clinical Cancer Research

DOI: https://doi.org/10.1186/s13046-019-1147-6

Paper CAR-engineered NK cells; a promising therapeutic option for treatment of hematological malignancies

Marofi, Faroogh; Saleh, Marwan Mahmood; Rahman, Heshu Sulaiman et al. · 2021 · Stem Cell Research & Therapy · DOI

Full title: CAR-engineered NK cells; a promising therapeutic option for treatment of hematological malignancies

Authors: Marofi, Faroogh; Saleh, Marwan Mahmood; Rahman, Heshu Sulaiman; Suksatan, Wanich; Al‐Gazally, Moaed E.; Abdelbasset, Walid Kamal; Thangavelu, Lakshmi; Yumashev, Alexei Valerievich; Hassanzadeh, Ali; Yazdanifar, Mahboubeh; Motavalli, Roza; Pathak, Yashwant; Naimi, Adel; Baradaran, Behzad; Nikoo, Marzieh; Khiavi, Farhad Motavalli

Year: 2021

Venue: Stem Cell Research & Therapy

DOI: https://doi.org/10.1186/s13287-021-02462-y

Paper New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management

Kroschinsky, Frank; Stölzel, Friedrich; Bonin, Simone von et al. · 2017 · Critical Care · DOI

Full title: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management

Authors: Kroschinsky, Frank; Stölzel, Friedrich; Bonin, Simone von; Beutel, Gernot; Kochanek, Matthias; Kiehl, Michael; Schellongowski, Peter; Schellongowski, Peter

Year: 2017

Venue: Critical Care

DOI: https://doi.org/10.1186/s13054-017-1678-1

Paper Renaissance of armored immune effector cells, CAR-NK cells, brings the higher hope for successful cancer therapy

Marofi, Faroogh; Rahman, Heshu Sulaiman; Thangavelu, Lakshmi et al. · 2021 · Stem Cell Research & Therapy · DOI

Full title: Renaissance of armored immune effector cells, CAR-NK cells, brings the higher hope for successful cancer therapy

Authors: Marofi, Faroogh; Rahman, Heshu Sulaiman; Thangavelu, Lakshmi; Dorofeev, A. E.; Bayas-Morejón, Favián; Shirafkan, Naghmeh; Shomali, Navid; Chartrand, Max Stanley; Jarahian, Mostafa; Vahedi, Ghasem; Mohammed, Rebar N.; Shahrokh, Somayeh; Akbari, Morteza; Khiavi, Farhad Motavalli

Year: 2021

Venue: Stem Cell Research & Therapy

DOI: https://doi.org/10.1186/s13287-021-02251-7

Paper Natural killer cell therapy for hematologic malignancies: successes, challenges, and the future

Lamb, Margaret; Rangarajan, Hemalatha G.; Tullius, Brian P. et al. · 2021 · Stem Cell Research & Therapy · DOI

Full title: Natural killer cell therapy for hematologic malignancies: successes, challenges, and the future

Authors: Lamb, Margaret; Rangarajan, Hemalatha G.; Tullius, Brian P.; Lee, Dean A.

Year: 2021

Venue: Stem Cell Research & Therapy

DOI: https://doi.org/10.1186/s13287-021-02277-x

Paper Chimeric antigen receptor-engineered NK cells: new weapons of cancer immunotherapy with great potential

Wang, Xiao; Yang, Xuejiao; Yuan, Xiang et al. · 2022 · Experimental Hematology and Oncology · DOI

Full title: Chimeric antigen receptor-engineered NK cells: new weapons of cancer immunotherapy with great potential

Authors: Wang, Xiao; Yang, Xuejiao; Yuan, Xiang; Wang, Wenbo; Wang, Yueying

Year: 2022

Venue: Experimental Hematology and Oncology

DOI: https://doi.org/10.1186/s40164-022-00341-7

Paper The paradoxical role of cytokines and chemokines at the tumor microenvironment: a comprehensive review

Abdul‐Rahman, Toufik; Ghosh, Shankhaneel; Badar, Sarah M. et al. · 2024 · European journal of medical research · DOI

Full title: The paradoxical role of cytokines and chemokines at the tumor microenvironment: a comprehensive review

Authors: Abdul‐Rahman, Toufik; Ghosh, Shankhaneel; Badar, Sarah M.; Nazir, Abubakar; Bamigbade, Gafar Babatunde; Aji, Narjiss; Roy, Poulami; kachani, Hajar; Garg, Neil K.; Lawal, Lukman; Bliss, Zarah Sophia Blake; Awuah, Wireko Andrew; Atallah, Oday; Adebusoye, Favour Tope; Teslyk, Tetiana Petrivna; Sikora, Kateryna; Horbas, Viktoriia Anatoliivna

Year: 2024

Venue: European journal of medical research

DOI: https://doi.org/10.1186/s40001-024-01711-z

Paper Current approaches to develop “off-the-shelf” chimeric antigen receptor (CAR)-T cells for cancer treatment: a systematic review

Aparicio, Cristina; Acebal, Carlos; González‐Vallinas, Margarita · 2023 · Experimental Hematology and Oncology · DOI

Full title: Current approaches to develop “off-the-shelf” chimeric antigen receptor (CAR)-T cells for cancer treatment: a systematic review

Authors: Aparicio, Cristina; Acebal, Carlos; González‐Vallinas, Margarita

Year: 2023

Venue: Experimental Hematology and Oncology

DOI: https://doi.org/10.1186/s40164-023-00435-w

Paper Advances of CD19-directed chimeric antigen receptor-modified T cells in refractory/relapsed acute lymphoblastic leukemia

Wei, Guoqing; Ding, Lijuan; Wang, Jiasheng et al. · 2017 · Experimental Hematology and Oncology · DOI

Full title: Advances of CD19-directed chimeric antigen receptor-modified T cells in refractory/relapsed acute lymphoblastic leukemia

Authors: Wei, Guoqing; Ding, Lijuan; Wang, Jiasheng; Hu, Yongxian; Huang, He

Year: 2017

Venue: Experimental Hematology and Oncology

DOI: https://doi.org/10.1186/s40164-017-0070-9

Paper Engineering better chimeric antigen receptor T cells

Zhang, Hao; Zhao, Pu; Huang, He · 2020 · Experimental Hematology and Oncology · DOI

Full title: Engineering better chimeric antigen receptor T cells

Authors: Zhang, Hao; Zhao, Pu; Huang, He

Year: 2020

Venue: Experimental Hematology and Oncology

DOI: https://doi.org/10.1186/s40164-020-00190-2

Paper CAR-NK cells for cancer immunotherapy: from bench to bedside

Zhang, Leisheng; Yuan, Meng; Feng, Xiaoming et al. · 2022 · Biomarker Research · DOI

Full title: CAR-NK cells for cancer immunotherapy: from bench to bedside

Authors: Zhang, Leisheng; Yuan, Meng; Feng, Xiaoming; Han, Zhongchao

Year: 2022

Venue: Biomarker Research

DOI: https://doi.org/10.1186/s40364-022-00364-6

Paper Mechanisms underlying CD19-positive ALL relapse after anti-CD19 CAR T cell therapy and associated strategies

Nie, Yuru; Lu, Weiqing; Chen, Daiyu et al. · 2020 · Biomarker Research · DOI

Full title: Mechanisms underlying CD19-positive ALL relapse after anti-CD19 CAR T cell therapy and associated strategies

Authors: Nie, Yuru; Lu, Weiqing; Chen, Daiyu; Tu, Huilin; Guo, Zhenling; Zhou, Xuan; Li, Meifang; Tu, Sanfang; Li, Yuhua

Year: 2020

Venue: Biomarker Research

DOI: https://doi.org/10.1186/s40364-020-00197-1

Paper Strategies to enhance CAR-T persistence

Liu, Yue; An, Lingna; Huang, Ruihao et al. · 2022 · Biomarker Research · DOI

Full title: Strategies to enhance CAR-T persistence

Authors: Liu, Yue; An, Lingna; Huang, Ruihao; Xiong, Jingkang; Yang, Haoyu; Wang, Xiaoqi; Zhang, Xi

Year: 2022

Venue: Biomarker Research

DOI: https://doi.org/10.1186/s40364-022-00434-9

Paper Cytokine-induced killer cells promote antitumor immunity

Jiang, Jingting; Wu, Changping; Lu, Binfeng · 2013 · Journal of Translational Medicine · DOI

Full title: Cytokine-induced killer cells promote antitumor immunity

Authors: Jiang, Jingting; Wu, Changping; Lu, Binfeng

Year: 2013

Venue: Journal of Translational Medicine

DOI: https://doi.org/10.1186/1479-5876-11-83

Paper Chimeric antigen receptor-engineered T cells for cancer immunotherapy: progress and challenges

Han, Ethan Q; Li, Xiuling; Wang, Chunrong et al. · 2013 · Journal of Hematology & Oncology · DOI

Full title: Chimeric antigen receptor-engineered T cells for cancer immunotherapy: progress and challenges

Authors: Han, Ethan Q; Li, Xiuling; Wang, Chunrong; Li, Tian-Fang; Han, Shuangyin

Year: 2013

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/1756-8722-6-47

Paper Spontaneous apoptosis of blood dendritic cells in patients with breast cancer

Pinzón‐Charry, Alberto; Maxwell, Tammy; McGuckin, Michael A. et al. · 2005 · Breast Cancer Research · DOI

Full title: Spontaneous apoptosis of blood dendritic cells in patients with breast cancer

Authors: Pinzón‐Charry, Alberto; Maxwell, Tammy; McGuckin, Michael A.; Schmidt, Christopher; Furnival, Colin; López, J. Alejandro

Year: 2005

Venue: Breast Cancer Research

DOI: https://doi.org/10.1186/bcr1361

Paper Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors

Abigail K. Grosskopf; Louai Labanieh; D. Klysz et al. · 2021 · bioRxiv · DOI

Full title: Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors

Authors: Abigail K. Grosskopf; Louai Labanieh; D. Klysz; Gillie A. Roth; P. Xu; Omokolade Adebowale; Emily C. Gale; C. Jons; J. Klich; Jerry Yan; Caitlin L. Maikawa; Santiago Correa; Ben S. Ou; Andrea I. d’Aquino; J. Cochran; Ovijit Chaudhuri; C. Mackall; Eric A. Appel

Year: 2021

Venue: bioRxiv

DOI: https://doi.org/10.1101/2021.12.20.473538

Paper Manufacturing CD20/CD19-targeted iCasp9 regulatable CAR-TSCM cells using qCART, the Quantum pBac-based CAR-T system

Peter S. Chang; Yi-Chun Chen; Wei-Kai Hua et al. · 2022 · bioRxiv · DOI

Full title: Manufacturing CD20/CD19-targeted iCasp9 regulatable CAR-TSCM cells using qCART, the Quantum pBac-based CAR-T system

Authors: Peter S. Chang; Yi-Chun Chen; Wei-Kai Hua; J. C. Hsu; Jui-Cheng Tsai; Yi-Wun Huang; Yi-Hsin Kao; Pei-Hua Wu; Yi-fang Chang; M. Chang; Yu-Cheng Chang; Shiou-Ling Jian; J. Lai; M. Lai; Wei-Cheng Yang; Chia-Ning Shen; Kuo-Lan Karen Wen; Sareina Chiung-Yuan Wu

Year: 2022

Venue: bioRxiv

DOI: https://doi.org/10.1101/2022.05.03.490475

Paper Efficient multiplex non-viral engineering and expansion of polyclonal γδ CAR-T cells for immunotherapy

Jacob Bridge; Matthew J. Johnson; Jihyun Kim et al. · 2024 · bioRxiv · DOI

Full title: Efficient multiplex non-viral engineering and expansion of polyclonal γδ CAR-T cells for immunotherapy

Authors: Jacob Bridge; Matthew J. Johnson; Jihyun Kim; Sophia Wenthe; Joshua B. Krueger; B. Wick; Mitchell G. Kluesner; Andrew T. Crane; Jason B Bell; Joseph G. Skeate; B. Moriarity; Beau R. Webber

Year: 2024

Venue: bioRxiv

DOI: https://doi.org/10.1101/2024.09.03.611042

Paper Development of Ingenui-T, a Novel Vein-to-Vein Solution for Rapid Autologous CAR T-Cell Manufacturing Starting From Whole Blood, for the Treatment of Autoimmune Diseases

D. Anaya; B. Kwong; Soo Park et al. · 2024 · bioRxiv · DOI

Full title: Development of Ingenui-T, a Novel Vein-to-Vein Solution for Rapid Autologous CAR T-Cell Manufacturing Starting From Whole Blood, for the Treatment of Autoimmune Diseases

Authors: D. Anaya; B. Kwong; Soo Park; S. Biswas; J. Jeevan; M. Strobach; N. Khoshnoodi; A. Register; T. Klasson; S. Foos-Russ; J. Zeng; J. Banuelos; C. Gibson; J. Bravo; Jeanne Flandez; T. Van Blarcom; K. Walker

Year: 2024

Venue: bioRxiv

DOI: https://doi.org/10.1101/2024.01.24.576713

Paper Genome-wide CRISPRa screens nominate modulators of CAR T cell survival within distinct tumor cytokine milieus

Benjamin C Curtis; Cailyn H. Spurrell; Lindsay Flint et al. · 2024 · bioRxiv · DOI

Full title: Genome-wide CRISPRa screens nominate modulators of CAR T cell survival within distinct tumor cytokine milieus

Authors: Benjamin C Curtis; Cailyn H. Spurrell; Lindsay Flint; Aalton M Lande; Marissa Leonardi; James M Rosser; Ardizon Valdez; Nat Murren; Tiffanie Chai; Michael Fitzgerald; Jasmin Martinez-Reyes; Chris Saxby; Shannon K Oda; Michael Jensen

Year: 2024

Venue: bioRxiv

DOI: https://doi.org/10.1101/2024.03.16.583115

Paper Gene editing of CD3 epsilon gene to redirect regulatory T cells for adoptive T cell transfer

Weijie Du; F. Noyan; Oliver McCallion et al. · 2024 · bioRxiv · DOI

Full title: Gene editing of CD3 epsilon gene to redirect regulatory T cells for adoptive T cell transfer

Authors: Weijie Du; F. Noyan; Oliver McCallion; Vanessa Drosdek; Jonas Kath; Viktor Glaser; Carla Fuster-García; Mingxing Yang; M. Stein; Olaf Weber; J. Polansky; T. Cathomen; E. Jaeckel; J. Hester; F. Issa; Hans-Dieter Volk; Michael Schmueck-Henneresse; Petra Reinke; D. Wagner

Year: 2024

Venue: bioRxiv

DOI: https://doi.org/10.1101/2024.03.18.584896

Paper RELB Reprograms Exhausted Tumor-Infiltrating Lymphocytes for Improved Adoptive Cell Therapy

Christian D. McRoberts Amador; Rachel E. Conover; Michael C. Brown et al. · 2025 · bioRxiv · DOI

Full title: RELB Reprograms Exhausted Tumor-Infiltrating Lymphocytes for Improved Adoptive Cell Therapy

Authors: Christian D. McRoberts Amador; Rachel E. Conover; Michael C. Brown; Liliana S. Lyniv; P. Noldner; Ying Zhou; Aretha R. Gao; Sean R. McCutcheon; S. Antonia; Charles A. Gersbach

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.10.11.681829

Paper Engineering CD3 Subunits with Endoplasmic Reticulum Retention Signal Facilitates Allogeneic CAR T Cell Production

Hamidreza Ebrahimiyan; Ali Sayadmanesh; Mahdi Hesaraki et al. · 2024 · bioRxiv · DOI

Full title: Engineering CD3 Subunits with Endoplasmic Reticulum Retention Signal Facilitates Allogeneic CAR T Cell Production

Authors: Hamidreza Ebrahimiyan; Ali Sayadmanesh; Mahdi Hesaraki; Marzieh Ebrahimi; Hossein Baharand; Mohsen Basiri

Year: 2024

Venue: bioRxiv

DOI: https://doi.org/10.1101/2024.09.22.614328

Paper Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy

Tao Zheng; Keerthana Ramanathan; Maria Ormhøj et al. · 2025 · bioRxiv · DOI

Full title: Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.04.10.648181

Paper Universal Dual-Target CAR-γδT Cells Targeting B7-H3 and IL13Rα2 for Glioblastoma Therapy

Yang Xu; Yunhao Ye; Yi Wang et al. · 2025 · bioRxiv · DOI

Full title: Universal Dual-Target CAR-γδT Cells Targeting B7-H3 and IL13Rα2 for Glioblastoma Therapy

Authors: Yang Xu; Yunhao Ye; Yi Wang; Guangna Liu

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.05.14.653035

Paper In vivo CRISPR screens identify key modifiers of CAR T cell function in myeloma

Felix Korell; Nelson H. Knudsen; T. Kienka et al. · 2024 · bioRxiv · DOI

Full title: In vivo CRISPR screens identify key modifiers of CAR T cell function in myeloma

Authors: Felix Korell; Nelson H. Knudsen; T. Kienka; Giulia Escobar; Celeste Nobrega; Seth Anderson; Andy Cheng; Maria Zschummel; Amanda A Bouffard; M. Kann; Sadie Goncalves; Hans W. Pope; Mitra Pezeshki; Alexander Rojas; Juliette S. M. T. Suermondt; M. Phillips; Trisha R. Berger; Sangwoo Park; Diego Salas-Benito; Elijah P Darnell; F. Birocchi; M. Leick; R. Larson; John G Doench; Debattama R. Sen; Kathleen B. Yates; R. Manguso; Marcela V. Maus

Year: 2024

Venue: bioRxiv

DOI: https://doi.org/10.1101/2024.11.19.624352

Paper Functionalized microcarriers improve T cell manufacturing by facilitating migratory memory T cell production and increasing CD4/CD8 ratio

Nathan Dwarshuis; Hannah W. Song; Anokhi Patel et al. · 2019 · bioRxiv · DOI

Full title: Functionalized microcarriers improve T cell manufacturing by facilitating migratory memory T cell production and increasing CD4/CD8 ratio

Authors: Nathan Dwarshuis; Hannah W. Song; Anokhi Patel; Theresa Kotanchek; K. Roy

Year: 2019

Venue: bioRxiv

DOI: https://doi.org/10.1101/646760

Paper An inherent T cell-activating mRNA delivery platform for in vivo CAR T generation

Qiannan Cao; Yingli Yao; Wenming Zheng et al. · 2025 · bioRxiv · DOI

Full title: An inherent T cell-activating mRNA delivery platform for in vivo CAR T generation

Authors: Qiannan Cao; Yingli Yao; Wenming Zheng; Hongqian Liu; Mingxia Jiang; Dayang Xie; Siting Zhang; Pijun Su; Huilin Yuan; Xiaoyuan Chen; Huapan Fang; Huayu Tian

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.11.19.688592

Paper A Transient Immunostimulatory Niche Synergizes Adoptive and Endogenous Immunity for Enhanced Tumor Control

Anahita Nejatfard; J. Klich; Noah Eckman et al. · 2025 · bioRxiv · DOI

Full title: A Transient Immunostimulatory Niche Synergizes Adoptive and Endogenous Immunity for Enhanced Tumor Control

Authors: Anahita Nejatfard; J. Klich; Noah Eckman; Sophia J. Bailey; Kyra Gillard; Daniel Ramos Mejia; Ben S. Ou; Jerry Yan; John W. Hickey; Eric A. Appel

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.08.22.671875

Paper Dynamic estimation of metabolic state during CAR T cell production and the relationship of early metabolism to final therapeutic product

N. Suhas; Wei-Xiang Sin; Denise Bei et al. · 2025 · bioRxiv · DOI

Full title: Dynamic estimation of metabolic state during CAR T cell production and the relationship of early metabolism to final therapeutic product

Authors: N. Suhas; Wei-Xiang Sin; Denise Bei; Lin Teo; Faris Kairi; Yen Hoon Luah; Francesca Lorraine; Wei Inng Lim; Michaela Su-Fern Seng; Yen Soh; Yie Hou Lee; Lisa Tucker-Kellogg; Michael E. Birnbaum; R. Ram

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.05.11.653250

Paper Antigen-scaffolds drive preferential expansion of functional genetically engineered CAR and TCR T cells

K. H. Johansen; Keerthana Ramanathan; C. Rodriguez-Pardo et al. · 2025 · bioRxiv · DOI

Full title: Antigen-scaffolds drive preferential expansion of functional genetically engineered CAR and TCR T cells

Authors: K. H. Johansen; Keerthana Ramanathan; C. Rodriguez-Pardo; Anne Kargaard Gjelstrup; H. Halldórsdóttir; L. F. Voss; S. Tvingsholm; Laura Stentoft Grand; Edoardo Dionisio; A. H. Skriver; Louise Pii Frederiksen; Mette Bjørnson; Marcus Svensson-Frej; Maria Ormhøj; S. Hadrup

Year: 2025

Venue: bioRxiv

DOI: https://doi.org/10.1101/2025.11.01.686037

Paper Cytokines in Cancer Immunotherapy

Waldmann, Thomas A. · 2017 · Cold Spring Harbor Perspectives in Biology · DOI

Full title: Cytokines in Cancer Immunotherapy

Authors: Waldmann, Thomas A.

Year: 2017

Venue: Cold Spring Harbor Perspectives in Biology

DOI: https://doi.org/10.1101/cshperspect.a028472

Paper Selection and expansion of natural killer cells for NK cell-based immunotherapy

Becker, P. S. A.; Suck, Garnet; Nowakowska, Paulina et al. · 2016 · Cancer Immunology Immunotherapy · DOI

Full title: Selection and expansion of natural killer cells for NK cell-based immunotherapy

Authors: Becker, P. S. A.; Suck, Garnet; Nowakowska, Paulina; Ullrich, Evelyn; Seifried, Erhard; Bader, Peter; Tonn, Torsten; Seidl, Christian

Year: 2016

Venue: Cancer Immunology Immunotherapy

DOI: https://doi.org/10.1007/s00262-016-1792-y

Paper Adoptive cellular therapies: the current landscape

Rohaan, Maartje W.; Wilgenhof, Sofie; Haanen, John B.A.G. · 2018 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · DOI

Full title: Adoptive cellular therapies: the current landscape

Authors: Rohaan, Maartje W.; Wilgenhof, Sofie; Haanen, John B.A.G.

Year: 2018

Venue: Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin

DOI: https://doi.org/10.1007/s00428-018-2484-0

Paper Challenges of NK cell-based immunotherapy in the new era

Fang, Fang; Xiao, Weihua; Tian, Zhigang · 2018 · Frontiers of Medicine · DOI

Full title: Challenges of NK cell-based immunotherapy in the new era

Authors: Fang, Fang; Xiao, Weihua; Tian, Zhigang

Year: 2018

Venue: Frontiers of Medicine

DOI: https://doi.org/10.1007/s11684-018-0653-9

Paper GD2-specific chimeric antigen receptor-modified T cells for the treatment of refractory and/or recurrent neuroblastoma in pediatric patients

Yu, Lihua; Huang, Lulu; Lin, Danna et al. · 2021 · Journal of Cancer Research and Clinical Oncology · DOI

Full title: GD2-specific chimeric antigen receptor-modified T cells for the treatment of refractory and/or recurrent neuroblastoma in pediatric patients

Authors: Yu, Lihua; Huang, Lulu; Lin, Danna; Lai, Xiaorong; Wu, Li; Liao, Xu; Liu, Jiale; Zeng, Yinghua; Liang, Lichan; Zhang, Guanmei; Wang, Bin; Zhu, Wu; Tao, Shaohua; Liu, Yuchen; Jiao, Cheng; Chang, Lung‐Ji; Yang, Lihua

Year: 2021

Venue: Journal of Cancer Research and Clinical Oncology

DOI: https://doi.org/10.1007/s00432-021-03839-5

Paper Optimization of ex vivo hematopoietic stem cell expansion in intermittent dynamic cultures

Yong-Soo Choi; Sang-Eun Noh; Sang-Min Lim et al. · 2010 · Biotechnology Letters · DOI

Full title: Optimization of ex vivo hematopoietic stem cell expansion in intermittent dynamic cultures

Authors: Yong-Soo Choi; Sang-Eun Noh; Sang-Min Lim; Dong-Il Kim

Year: 2010

Venue: Biotechnology Letters

DOI: https://doi.org/10.1007/s10529-010-0355-0

Paper Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy

Zhang, Zhao; Jiang, Jun; Wu, Xiaodong et al. · 2019 · Frontiers of Medicine · DOI

Full title: Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy

Authors: Zhang, Zhao; Jiang, Jun; Wu, Xiaodong; Zhang, Mengyao; Luo, Dan; Zhang, Renyu; Li, Shiyou; He, You‐Wen; Bian, Huijie; Chen, Zhi‐Nan

Year: 2019

Venue: Frontiers of Medicine

DOI: https://doi.org/10.1007/s11684-019-0683-y

Paper NK cell-based cancer immunotherapy: from basic biology to clinical application

Li, Yang; Yin, Jie; Li, Ting et al. · 2015 · Science China Life Sciences · DOI

Full title: NK cell-based cancer immunotherapy: from basic biology to clinical application

Authors: Li, Yang; Yin, Jie; Li, Ting; Huang, Shan; Yan, Han; Leavenworth, Jianmei W.; Wang, Xi

Year: 2015

Venue: Science China Life Sciences

DOI: https://doi.org/10.1007/s11427-015-4970-9

Paper Biology and clinical application of CAR T cells for B cell malignancies

Davila, Marco L.; Sadelain, Michel · 2016 · International Journal of Hematology · DOI

Full title: Biology and clinical application of CAR T cells for B cell malignancies

Authors: Davila, Marco L.; Sadelain, Michel

Year: 2016

Venue: International Journal of Hematology

DOI: https://doi.org/10.1007/s12185-016-2039-6

Paper Advances in CAR-T cell therapy for refractory diseases: challenges, innovations, clinical breakthroughs, and future prospects

Qibin Liao; Yunyu Mao; Meiqi Feng et al. · 2025 · Clinical Cancer Bulletin · DOI

Full title: Advances in CAR-T cell therapy for refractory diseases: challenges, innovations, clinical breakthroughs, and future prospects

Authors: Qibin Liao; Yunyu Mao; Meiqi Feng; Nairong Zheng; Xiangqing Ding; Xiaoyan Zhang; Zhongfang Wang; Jianqing Xu

Year: 2025

Venue: Clinical Cancer Bulletin

DOI: https://doi.org/10.1007/s44272-025-00050-2

Paper Tumor-infiltrating lymphocyte expansion protocols for adoptive cell therapy in cancer

Daniel Tovar Manzano; Nabil Subhi-Issa; Alejandro Pereiro-Rodríguez et al. · 2025 · Cellular Oncology · DOI

Full title: Tumor-infiltrating lymphocyte expansion protocols for adoptive cell therapy in cancer

Authors: Daniel Tovar Manzano; Nabil Subhi-Issa; Alejandro Pereiro-Rodríguez; I. López Cade; María Mateos González; M. Fernández Arquero; P. Pérez Segura; Cristina Ujaldón Miró; S. Sánchez-Ramón; Alberto Ocaña; María Guzmán Fulgencio

Year: 2025

Venue: Cellular Oncology

DOI: https://doi.org/10.1007/s13402-025-01112-2

Paper Chimeric Antigen Receptor-Engineered T Cells for the Treatment of Metastatic Prostate Cancer

Hillerdal, Victoria; Essand, Magnus · 2015 · BioDrugs · DOI

Full title: Chimeric Antigen Receptor-Engineered T Cells for the Treatment of Metastatic Prostate Cancer

Authors: Hillerdal, Victoria; Essand, Magnus

Year: 2015

Venue: BioDrugs

DOI: https://doi.org/10.1007/s40259-015-0122-9

Paper Pediatric Cancer Immunotherapy: Opportunities and Challenges

Wedekind, Mary Frances; Denton, Nicholas; Chen, Chun‐Yu et al. · 2018 · Pediatric Drugs · DOI

Full title: Pediatric Cancer Immunotherapy: Opportunities and Challenges

Authors: Wedekind, Mary Frances; Denton, Nicholas; Chen, Chun‐Yu; Cripe, Timothy P.

Year: 2018

Venue: Pediatric Drugs

DOI: https://doi.org/10.1007/s40272-018-0297-x

Paper Impact of Manufacturing Procedures on CAR T Cell Functionality

Watanabe, Norihiro; Mo, Feiyan; McKenna, Mary K. · 2022 · Frontiers in Immunology · DOI

Full title: Impact of Manufacturing Procedures on CAR T Cell Functionality

Authors: Watanabe, Norihiro; Mo, Feiyan; McKenna, Mary K.

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.876339

Paper Natural Killer Cells in SARS-CoV-2 Infection: Pathophysiology and Therapeutic Implications

Vito, Clara Di; Calcaterra, Francesca; Coianiz, Nicolò et al. · 2022 · Frontiers in Immunology · DOI

Full title: Natural Killer Cells in SARS-CoV-2 Infection: Pathophysiology and Therapeutic Implications

Authors: Vito, Clara Di; Calcaterra, Francesca; Coianiz, Nicolò; Terzoli, Sara; Voza, Antonio; Mikulak, Joanna; Bella, Silvia Della; Mavilio, Domenico

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.888248

Paper CAR-T Cell Performance: How to Improve Their Persistence?

Gina López-Cantillo; C. Urueña; Bernardo Camacho et al. · 2022 · Frontiers in Immunology · DOI

Full title: CAR-T Cell Performance: How to Improve Their Persistence?

Authors: Gina López-Cantillo; C. Urueña; Bernardo Camacho; Cesar A. Ramirez-Segura

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.878209

Paper Cytokine Based Immunotherapy for Cancer and Lymphoma: Biology, Challenges and Future Perspectives

Atallah‐Yunes, Suheil Albert; Robertson, Michael J. · 2022 · Frontiers in Immunology · DOI

Full title: Cytokine Based Immunotherapy for Cancer and Lymphoma: Biology, Challenges and Future Perspectives

Authors: Atallah‐Yunes, Suheil Albert; Robertson, Michael J.

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.872010

Paper Cytokines as an important player in the context of CAR-T cell therapy for cancer: Their role in tumor immunomodulation, manufacture, and clinical implications

C. R. F. Silveira; Amanda Cristina Corveloni; S. R. Caruso et al. · 2022 · Frontiers in Immunology · DOI

Full title: Cytokines as an important player in the context of CAR-T cell therapy for cancer: Their role in tumor immunomodulation, manufacture, and clinical implications

Authors: C. R. F. Silveira; Amanda Cristina Corveloni; S. R. Caruso; Nathália Araújo Macêdo; Natália Moscheta Brussolo; Felipe Haddad; T. R. Fernandes; P. V. de Andrade; M. Orellana; R. Guerino-Cunha

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.947648

Paper Preclinical and clinical studies of CAR-NK-cell therapies for malignancies

Li, Hongwen; Song, Wenting; Li, Zhaoming et al. · 2022 · Frontiers in Immunology · DOI

Full title: Preclinical and clinical studies of CAR-NK-cell therapies for malignancies

Authors: Li, Hongwen; Song, Wenting; Li, Zhaoming; Zhang, Mingzhi

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.992232

Paper From bench to bedside: the history and progress of CAR T cell therapy

Mitra, Aroshi; Barua, Amrita; Huang, Luping et al. · 2023 · Frontiers in Immunology · DOI

Full title: From bench to bedside: the history and progress of CAR T cell therapy

Authors: Mitra, Aroshi; Barua, Amrita; Huang, Luping; Ganguly, Siddhartha; Feng, Qin; He, Bin

Year: 2023

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2023.1188049

Paper CAR T-Cell-Based gene therapy for cancers: new perspectives, challenges, and clinical developments

Jogalekar, Manasi P.; Rajendran, Ramya Lakshmi; Khan, Fatima et al. · 2022 · Frontiers in Immunology · DOI

Full title: CAR T-Cell-Based gene therapy for cancers: new perspectives, challenges, and clinical developments

Authors: Jogalekar, Manasi P.; Rajendran, Ramya Lakshmi; Khan, Fatima; Dmello, Crismita; Gangadaran, Prakash; Ahn, Byeong‐Cheol

Year: 2022

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2022.925985

Paper Current and future concepts for the generation and application of genetically engineered CAR-T and TCR-T cells

Hiltensperger, Michael; Krackhardt, Angela M. · 2023 · Frontiers in Immunology · DOI

Full title: Current and future concepts for the generation and application of genetically engineered CAR-T and TCR-T cells

Authors: Hiltensperger, Michael; Krackhardt, Angela M.

Year: 2023

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2023.1121030

Paper T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications

Chi, Xiaoxia; Luo, Shahang; Ye, Peng et al. · 2023 · Frontiers in Immunology · DOI

Full title: T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications

Authors: Chi, Xiaoxia; Luo, Shahang; Ye, Peng; Hwang, Wei‐Lun; Cha, Jong‐Ho; Yan, Xiuwen; Yang, Wenhao

Year: 2023

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2023.1104771

Paper Advancements in CAR-NK therapy: lessons to be learned from CAR-T therapy

Kilgour, Marisa K.; Bastin, Donald; Lee, Seung‐Hwan et al. · 2023 · Frontiers in Immunology · DOI

Full title: Advancements in CAR-NK therapy: lessons to be learned from CAR-T therapy

Authors: Kilgour, Marisa K.; Bastin, Donald; Lee, Seung‐Hwan; Ardolino, Michele; McComb, Scott; Visram, Alissa

Year: 2023

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2023.1166038

Paper Targeting of chimeric antigen receptor T cell metabolism to improve therapeutic outcomes

Priyanka Nanjireddy; S. Olejniczak; N. Buxbaum · 2023 · Frontiers in Immunology · DOI

Full title: Targeting of chimeric antigen receptor T cell metabolism to improve therapeutic outcomes

Authors: Priyanka Nanjireddy; S. Olejniczak; N. Buxbaum

Year: 2023

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2023.1121565

Paper Good manufacturing practice-grade generation of CD19 and CD123-specific CAR-T cells using piggyBac transposon and allogeneic feeder cells in patients diagnosed with B-cell non-Hodgkin lymphoma and acute myeloid leukemia

Martin Mucha; M. Štach; I. Kaštánková et al. · 2024 · Frontiers in Immunology · DOI

Full title: Good manufacturing practice-grade generation of CD19 and CD123-specific CAR-T cells using piggyBac transposon and allogeneic feeder cells in patients diagnosed with B-cell non-Hodgkin lymphoma and acute myeloid leukemia

Authors: Martin Mucha; M. Štach; I. Kaštánková; Jana Rychlá; Jan Vydra; Petr Lesný; P. Otáhal

Year: 2024

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2024.1415328

Paper Engineered T cells from induced pluripotent stem cells: from research towards clinical implementation

Ratchapong Netsrithong; Laura Garcia-Perez; M. Themeli · 2024 · Frontiers in Immunology · DOI

Full title: Engineered T cells from induced pluripotent stem cells: from research towards clinical implementation

Authors: Ratchapong Netsrithong; Laura Garcia-Perez; M. Themeli

Year: 2024

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2023.1325209

Paper Automated manufacturing and characterization of clinical grade autologous CD20 CAR T cells for the treatment of patients with stage III/IV melanoma

Krasimira Aleksandrova; Jana Leise; C. Priesner et al. · 2024 · Frontiers in Immunology · DOI

Full title: Automated manufacturing and characterization of clinical grade autologous CD20 CAR T cells for the treatment of patients with stage III/IV melanoma

Authors: Krasimira Aleksandrova; Jana Leise; C. Priesner; M. Aktas; Michael Apel; M. Assenmacher; I. Bürger; A. Richter; Pia Altefrohne; Christin Schubert; A. Holzinger; Markus Barden; Valerie Bezler; M. von Bergwelt-Baildon; P. Borchmann; L. Goudeva; W. Glienke; L. Arseniev; R. Esser; Hinrich Abken; Ulrike Koehl

Year: 2024

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2024.1328368

Paper Engineering safe anti-CD19-CD28ζ CAR T cells with CD8a hinge domain in serum-free media for adoptive immunotherapy

Muthuganesh Muthuvel; Thamizhselvi Ganapathy; Trent Spencer et al. · 2025 · Frontiers in Immunology · DOI

Full title: Engineering safe anti-CD19-CD28ζ CAR T cells with CD8a hinge domain in serum-free media for adoptive immunotherapy

Authors: Muthuganesh Muthuvel; Thamizhselvi Ganapathy; Trent Spencer; S. S. Raikar; Saravanabhavan Thangavel; Alok Srivastava; Sunil Martin

Year: 2025

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2025.1545549

Paper A quality-by-design approach to improve process understanding and optimise the production and quality of CAR-T cells in automated stirred-tank bioreactors

Tiffany Hood; F. Slingsby; V. Sandner et al. · 2024 · Frontiers in Immunology · DOI

Full title: A quality-by-design approach to improve process understanding and optimise the production and quality of CAR-T cells in automated stirred-tank bioreactors

Authors: Tiffany Hood; F. Slingsby; V. Sandner; W. Geis; Timo Schmidberger; Nicola Bevan; Quentin Vicard; J. Hengst; Pierre Springuel; Noushin Dianat; Q. Rafiq

Year: 2024

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2024.1335932

Paper Bio-functional hydrogel coated membranes to decrease T-cell exhaustion in manufacturing of CAR T-cells

Aida López Ruiz; Eric D Slaughter; Kartik Bomb et al. · 2025 · Frontiers in Immunology · DOI

Full title: Bio-functional hydrogel coated membranes to decrease T-cell exhaustion in manufacturing of CAR T-cells

Authors: Aida López Ruiz; Eric D Slaughter; Kartik Bomb; Samantha L Swedzinski; Paige J LeValley; Zaining Yun; Jacob McCoskey; Kara Levine; Jonathan Steen; Joseph Almasian; Aparajita Chatterjee; Christina Carbrello; Du-Sang Chang; Hubaida Fuseini; Y. Abassi; Abraham M. Lenhoff; C. Fromen; April M Kloxin

Year: 2025

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2025.1513148

Paper Enabling Allogeneic T Cell-Based Therapies: Scalable Stirred-Tank Bioreactor Mediated Manufacturing

H. Gatla; N. Uth; Y. Levinson et al. · 2022 · Frontiers in Medical Technology · DOI

Full title: Enabling Allogeneic T Cell-Based Therapies: Scalable Stirred-Tank Bioreactor Mediated Manufacturing

Authors: H. Gatla; N. Uth; Y. Levinson; A. Navaei; A. Sargent; S. Ramaswamy; Inbar Friedrich Ben-Nun

Year: 2022

Venue: Frontiers in Medical Technology

DOI: https://doi.org/10.3389/fmedt.2022.850565

Paper Perspectives on Systems Modeling of Human Peripheral Blood Mononuclear Cells

Sen, Partho; Kemppainen, Esko; Orešič, Matej · 2018 · Frontiers in Molecular Biosciences · DOI

Full title: Perspectives on Systems Modeling of Human Peripheral Blood Mononuclear Cells

Authors: Sen, Partho; Kemppainen, Esko; Orešič, Matej

Year: 2018

Venue: Frontiers in Molecular Biosciences

DOI: https://doi.org/10.3389/fmolb.2017.00096

Paper Industrializing Autologous Adoptive Immunotherapies: Manufacturing Advances and Challenges

Rohin K. Iyer; Paul A. Bowles; Howard Kim et al. · 2018 · Frontiers in Medicine · DOI

Full title: Industrializing Autologous Adoptive Immunotherapies: Manufacturing Advances and Challenges

Authors: Rohin K. Iyer; Paul A. Bowles; Howard Kim; A. Dulgar-Tulloch

Year: 2018

Venue: Frontiers in Medicine

DOI: https://doi.org/10.3389/fmed.2018.00150

Paper Cancer immunotherapy insights: key takeaways from the ADSCC bone marrow and cellular therapy congress 2024

Gisela Maria Suárez Formigo; Zaima Mazorra; Cinthia Olexen et al. · 2026 · Frontiers in Immunology · DOI

Full title: Cancer immunotherapy insights: key takeaways from the ADSCC bone marrow and cellular therapy congress 2024

Authors: Gisela Maria Suárez Formigo; Zaima Mazorra; Cinthia Olexen; Tamara Menéndez; Loubna Abdel Hadi; Rupert Handgretinger; Antonio Alfonso Bencomo Hernandez; Inas El Najjar; G. Coukos; Helen Sabzevari; Catherine Bollard; Daniel Couriel; David Wald; Mohamad Hamieh; Javier Briones; Fatima Al Kaabi; Y. Ventura-Carmenate

Year: 2026

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2025.1650023

Paper IL-21 Optimizes the CAR-T Cell Preparation Through Improving Lentivirus Mediated Transfection Efficiency of T Cells and Enhancing CAR-T Cell Cytotoxic Activities

L. Du; Yaru Nai; Meiying Shen et al. · 2021 · Frontiers in Molecular Biosciences · DOI

Full title: IL-21 Optimizes the CAR-T Cell Preparation Through Improving Lentivirus Mediated Transfection Efficiency of T Cells and Enhancing CAR-T Cell Cytotoxic Activities

Authors: L. Du; Yaru Nai; Meiying Shen; Tingting Li; Jingjing Huang; Xiaojian Han; Wang Wang; D. Pang; A. Jin

Year: 2021

Venue: Frontiers in Molecular Biosciences

DOI: https://doi.org/10.3389/fmolb.2021.675179

Paper Administration of granulocyte-macrophage colony-stimulating factor enhanced chimeric antigen receptor T-cell expansion and cellular immunity recovery without inducing cytokine release syndrome.

Jiang, Ying; Feng, Dan; Wang, Chun et al. · 2022 · Frontiers in medicine · DOI

Full title: Administration of granulocyte-macrophage colony-stimulating factor enhanced chimeric antigen receptor T-cell expansion and cellular immunity recovery without inducing cytokine release syndrome.

Authors: Jiang, Ying; Feng, Dan; Wang, Chun; Zhang, Yanlei; Zhao, Chuxian; Li, Su; Qin, Youwen; Chang, Alex H; Zhu, Jun

Year: 2022

Venue: Frontiers in medicine

DOI: https://doi.org/10.3389/fmed.2022.1042501

Paper A Metabolism Toolbox for CAR T Therapy

Xu, Xuequn; Gnanaprakasam, JN Rashida; Sherman, John et al. · 2019 · Frontiers in Oncology · DOI

Full title: A Metabolism Toolbox for CAR T Therapy

Authors: Xu, Xuequn; Gnanaprakasam, JN Rashida; Sherman, John; Wang, Ruoning

Year: 2019

Venue: Frontiers in Oncology

DOI: https://doi.org/10.3389/fonc.2019.00322

Paper The Third Generation Anti-HER2 Chimeric Antigen Receptor Mouse T Cells Alone or Together With Anti-PD1 Antibody Inhibits the Growth of Mouse Breast Tumor Cells Expressing HER2 in vitro and in Immune Competent Mice

Li, Panyuan; Yang, Lingcong; Li, Tong et al. · 2020 · Frontiers in Oncology · DOI

Full title: The Third Generation Anti-HER2 Chimeric Antigen Receptor Mouse T Cells Alone or Together With Anti-PD1 Antibody Inhibits the Growth of Mouse Breast Tumor Cells Expressing HER2 in vitro and in Immune Competent Mice

Authors: Li, Panyuan; Yang, Lingcong; Li, Tong; Bin, Shufang; Sun, Bohao; Huang, Yuting; Yang, Kaiyan; Shan, Daming; Gu, Haihua; Li, Hongzhi

Year: 2020

Venue: Frontiers in Oncology

DOI: https://doi.org/10.3389/fonc.2020.01143

Paper Altered T-Lymphocyte Biology Following High-Dose Melphalan and Autologous Stem Cell Transplantation With Implications for Adoptive T-Cell Therapy

T. Mika; Swetlana Ladigan-Badura; A. Maghnouj et al. · 2020 · Frontiers in Oncology · DOI

Full title: Altered T-Lymphocyte Biology Following High-Dose Melphalan and Autologous Stem Cell Transplantation With Implications for Adoptive T-Cell Therapy

Authors: T. Mika; Swetlana Ladigan-Badura; A. Maghnouj; B. Mustafa; S. Klein-Scory; A. Baraniskin; Sascha Döhring; Ilka Fuchs; S. Ehl; S. Hahn; R. Schroers

Year: 2020

Venue: Frontiers in Oncology

DOI: https://doi.org/10.3389/fonc.2020.568056

Paper TCR-T Immunotherapy: The Challenges and Solutions

Liu, Yating; Yan, Xin; Zhang, Fan et al. · 2022 · Frontiers in Oncology · DOI

Full title: TCR-T Immunotherapy: The Challenges and Solutions

Authors: Liu, Yating; Yan, Xin; Zhang, Fan; Zhang, Xiaoxia; Tang, Futian; Han, Zhijian; Li, Yumin

Year: 2022

Venue: Frontiers in Oncology

DOI: https://doi.org/10.3389/fonc.2021.794183

Paper Chimeric Antigen Receptor-T Cells: A Pharmaceutical Scope

Hernández-López, Alejandrina; Téllez-González, Mario A.; Mondragón‐Terán, Paul et al. · 2021 · Frontiers in Pharmacology · DOI

Full title: Chimeric Antigen Receptor-T Cells: A Pharmaceutical Scope

Authors: Hernández-López, Alejandrina; Téllez-González, Mario A.; Mondragón‐Terán, Paul; Meneses‐Acosta, Angélica

Year: 2021

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2021.720692

Paper Adoptive NK Cell Therapy - a Beacon of Hope in Multiple Myeloma Treatment

Son Hai Vu; Ha Hong Pham; Thao Thi Phuong Pham et al. · 2023 · Frontiers in Oncology · DOI

Full title: Adoptive NK Cell Therapy - a Beacon of Hope in Multiple Myeloma Treatment

Authors: Son Hai Vu; Ha Hong Pham; Thao Thi Phuong Pham; Thanh Thien Le; Manh-Cuong Vo; S. Jung; Je-Jung Lee; Xuan-Hung Nguyen

Year: 2023

Venue: Frontiers in Oncology

DOI: https://doi.org/10.3389/fonc.2023.1275076

Paper Umbilical Cord Blood Transplants: Current Status and Evolving Therapies

Gupta, Ashish O.; Wagner, John E. · 2020 · Frontiers in Pediatrics · DOI

Full title: Umbilical Cord Blood Transplants: Current Status and Evolving Therapies

Authors: Gupta, Ashish O.; Wagner, John E.

Year: 2020

Venue: Frontiers in Pediatrics

DOI: https://doi.org/10.3389/fped.2020.570282

Paper Breakthrough for Anticancer Immunotherapy: Current Advances in Manufacturing Protocols of Chimeric Antigen Receptor-Based Therapies

Yuxin Qian; Weiwei Ma; Xiao-Ning Xu · 2025 · Antibodies · DOI

Full title: Breakthrough for Anticancer Immunotherapy: Current Advances in Manufacturing Protocols of Chimeric Antigen Receptor-Based Therapies

Authors: Yuxin Qian; Weiwei Ma; Xiao-Ning Xu

Year: 2025

Venue: Antibodies

DOI: https://doi.org/10.3390/antib14040105

Paper Natural Killer Cells as Allogeneic Effectors in Adoptive Cancer Immunotherapy

Lupo, Kyle B.; Matosevic, Sandro · 2019 · Cancers · DOI

Full title: Natural Killer Cells as Allogeneic Effectors in Adoptive Cancer Immunotherapy

Authors: Lupo, Kyle B.; Matosevic, Sandro

Year: 2019

Venue: Cancers

DOI: https://doi.org/10.3390/cancers11060769

Paper Advantages and applications of CAR-expressing natural killer cells

Glienke, Wolfgang; Esser, Ruth; Priesner, Christoph et al. · 2015 · Frontiers in Pharmacology · DOI

Full title: Advantages and applications of CAR-expressing natural killer cells

Authors: Glienke, Wolfgang; Esser, Ruth; Priesner, Christoph; Suerth, Julia D.; Schambach, Axel; Wels, Winfried S.; Grez, Manuel; Kloeß, Stephan; Arseniev, Lubomir; Koehl, Ulrike

Year: 2015

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2015.00021

Paper Research progress of interleukin-15 in cancer immunotherapy

Cai, Menghan; Huang, Xuan; Huang, Xiting et al. · 2023 · Frontiers in Pharmacology · DOI

Full title: Research progress of interleukin-15 in cancer immunotherapy

Authors: Cai, Menghan; Huang, Xuan; Huang, Xiting; Ju, Dianwen; Zhu, Yi; Li, Ye

Year: 2023

Venue: Frontiers in Pharmacology

DOI: https://doi.org/10.3389/fphar.2023.1184703

Paper Assessing the Future of Solid Tumor Immunotherapy

Guha, Prajna; Heatherton, Kara R.; O’Connell, Kyle et al. · 2022 · Biomedicines · DOI

Full title: Assessing the Future of Solid Tumor Immunotherapy

Authors: Guha, Prajna; Heatherton, Kara R.; O’Connell, Kyle; Alexander, Ian S.; Katz, Steven C.

Year: 2022

Venue: Biomedicines

DOI: https://doi.org/10.3390/biomedicines10030655

Paper Mechanisms of Resistance to NK Cell Immunotherapy

Sordo‐Bahamonde, Christian; Vitale, Massimo; Lorenzo‐Herrero, Seila et al. · 2020 · Cancers · DOI

Full title: Mechanisms of Resistance to NK Cell Immunotherapy

Authors: Sordo‐Bahamonde, Christian; Vitale, Massimo; Lorenzo‐Herrero, Seila; López‐Soto, Alejandro; González, Segundo

Year: 2020

Venue: Cancers

DOI: https://doi.org/10.3390/cancers12040893

Paper NK-Cell-Mediated Targeting of Various Solid Tumors Using a B7-H3 Tri-Specific Killer Engager In Vitro and In Vivo

Vallera, Daniel A.; Ferrone, Soldano; Kodal, Behiye et al. · 2020 · Cancers · DOI

Full title: NK-Cell-Mediated Targeting of Various Solid Tumors Using a B7-H3 Tri-Specific Killer Engager In Vitro and In Vivo

Authors: Vallera, Daniel A.; Ferrone, Soldano; Kodal, Behiye; Hinderlie, Peter; Bendzick, Laura E.; Ettestad, Brianna; Hallstrom, Caroline; Zorko, Nicholas A.; Rao, Arpit; Fujioka, Naomi; Ryan, Charles J.; Geller, Melissa A.; Miller, Jeffrey S.; Felices, Martin

Year: 2020

Venue: Cancers

DOI: https://doi.org/10.3390/cancers12092659

Paper Ovarian Cancer Immunotherapy: Preclinical Models and Emerging Therapeutics

McCloskey, Curtis W.; Rodriguez, Galaxia M.; Galpin, Kristianne J.C. et al. · 2018 · Cancers · DOI

Full title: Ovarian Cancer Immunotherapy: Preclinical Models and Emerging Therapeutics

Authors: McCloskey, Curtis W.; Rodriguez, Galaxia M.; Galpin, Kristianne J.C.; Vanderhyden, Barbara C.

Year: 2018

Venue: Cancers

DOI: https://doi.org/10.3390/cancers10080244

Paper Clinical-Scale Production of CAR-T Cells for the Treatment of Melanoma Patients by mRNA Transfection of a CSPG4-Specific CAR under Full GMP Compliance

Wiesinger, Manuel; März, Johannes; Kummer, Mirko et al. · 2019 · Cancers · DOI

Full title: Clinical-Scale Production of CAR-T Cells for the Treatment of Melanoma Patients by mRNA Transfection of a CSPG4-Specific CAR under Full GMP Compliance

Authors: Wiesinger, Manuel; März, Johannes; Kummer, Mirko; Schuler, Gerold; Dörrie, Jan; Schuler‐Thurner, Beatrice; Schaft, Niels

Year: 2019

Venue: Cancers

DOI: https://doi.org/10.3390/cancers11081198

Paper 3D Culture Systems for Exploring Cancer Immunology

Fitzgerald, Allison A.; Li, Eric; Weiner, Louis M. · 2020 · Cancers · DOI

Full title: 3D Culture Systems for Exploring Cancer Immunology

Authors: Fitzgerald, Allison A.; Li, Eric; Weiner, Louis M.

Year: 2020

Venue: Cancers

DOI: https://doi.org/10.3390/cancers13010056

Paper Co-Expression of IL-7 Improves NKG2D-Based CAR T Cell Therapy on Prostate Cancer by Enhancing the Expansion and Inhibiting the Apoptosis and Exhaustion

He, Cong; Zhou, Ying; Li, Zhenlong et al. · 2020 · Cancers · DOI

Full title: Co-Expression of IL-7 Improves NKG2D-Based CAR T Cell Therapy on Prostate Cancer by Enhancing the Expansion and Inhibiting the Apoptosis and Exhaustion

Authors: He, Cong; Zhou, Ying; Li, Zhenlong; Farooq, Muhammad Asad; Ajmal, Iqra; Zhang, Hongmei; Zhang, Li; Tao, Lei; Yao, Jie; Du, Bing; Liu, Mingyao; Jiang, Wenzheng

Year: 2020

Venue: Cancers

DOI: https://doi.org/10.3390/cancers12071969

Paper Immunomodulatory Effects of IL-2 and IL-15; Implications for Cancer Immunotherapy

Yang, Ying; Lundqvist, Andreas · 2020 · Cancers · DOI

Full title: Immunomodulatory Effects of IL-2 and IL-15; Implications for Cancer Immunotherapy

Authors: Yang, Ying; Lundqvist, Andreas

Year: 2020

Venue: Cancers

DOI: https://doi.org/10.3390/cancers12123586

Paper CAR-NK Cells: A Chimeric Hope or a Promising Therapy?

M. Sabbah; Ludovic Jondreville; C. Lacan et al. · 2022 · Cancers · DOI

Full title: CAR-NK Cells: A Chimeric Hope or a Promising Therapy?

Authors: M. Sabbah; Ludovic Jondreville; C. Lacan; F. Norol; V. Vieillard; Damien Roos-Weil; Stephanie A Nguyen

Year: 2022

Venue: Cancers

DOI: https://doi.org/10.3390/cancers14153839

Paper NK Cell Therapy: A Rising Star in Cancer Treatment

Du, Nawen; Guo, Feifei; Wang, Yufeng et al. · 2021 · Cancers · DOI

Full title: NK Cell Therapy: A Rising Star in Cancer Treatment

Authors: Du, Nawen; Guo, Feifei; Wang, Yufeng; Cui, Jiuwei

Year: 2021

Venue: Cancers

DOI: https://doi.org/10.3390/cancers13164129

Paper Recent Advances and Challenges in Cancer Immunotherapy

Peterson, Chelsea; Denlinger, Nathan; Yang, Yiping · 2022 · Cancers · DOI

Full title: Recent Advances and Challenges in Cancer Immunotherapy

Authors: Peterson, Chelsea; Denlinger, Nathan; Yang, Yiping

Year: 2022

Venue: Cancers

DOI: https://doi.org/10.3390/cancers14163972

Paper Role of CAR T Cell Metabolism for Therapeutic Efficacy

Saborido, Judit Rial; Völkl, Simon; Aigner, Michael et al. · 2022 · Cancers · DOI

Full title: Role of CAR T Cell Metabolism for Therapeutic Efficacy

Authors: Saborido, Judit Rial; Völkl, Simon; Aigner, Michael; Mackensen, Andréas; Mougiakakos, Dimitrios

Year: 2022

Venue: Cancers

DOI: https://doi.org/10.3390/cancers14215442

Paper Development and Validation of a Good Manufacturing Process for IL-4-Driven Expansion of Chimeric Cytokine Receptor-Expressing CAR T-Cells

May C I van Schalkwyk; Sjoukje J. C. van der Stegen; Leticia Bosshard-Carter et al. · 2021 · Cells · DOI

Full title: Development and Validation of a Good Manufacturing Process for IL-4-Driven Expansion of Chimeric Cytokine Receptor-Expressing CAR T-Cells

Authors: May C I van Schalkwyk; Sjoukje J. C. van der Stegen; Leticia Bosshard-Carter; Helen Graves; S. Papa; Ana C. Parente-Pereira; F. Farzaneh; C. Fisher; A. Hope; A. Adami; J. Maher

Year: 2021

Venue: Cells

DOI: https://doi.org/10.3390/cells10071797

Paper DCision-making in tumors governs T cell anti-tumor immunity

Alfei, Francesca; Ho, Ping‐Chih; Lo, Wan‐Lin · 2021 · Oncogene · DOI

Full title: DCision-making in tumors governs T cell anti-tumor immunity

Authors: Alfei, Francesca; Ho, Ping‐Chih; Lo, Wan‐Lin

Year: 2021

Venue: Oncogene

DOI: https://doi.org/10.1038/s41388-021-01946-8

Paper Comparative analysis and process optimization for manufacturing CAR-T using the PiggyBac system derived from cryopreserved versus fresh PBMCs

Zenghui Xu; Ruyue Wang; Yuanjian Xu et al. · 2025 · Scientific Reports · DOI

Full title: Comparative analysis and process optimization for manufacturing CAR-T using the PiggyBac system derived from cryopreserved versus fresh PBMCs

Authors: Zenghui Xu; Ruyue Wang; Yuanjian Xu; Ruijuan Qiu; Jiangrui Chen; Linfeng Liu; Qijun Qian

Year: 2025

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-025-89686-7

Paper Dexamethasone Enhances CAR T Cell Persistence and Function by Upregulating Interleukin 7 Receptor

A. Munoz; Ryan Urak; Ellie Taus et al. · 2022 · bioRxiv · DOI

Full title: Dexamethasone Enhances CAR T Cell Persistence and Function by Upregulating Interleukin 7 Receptor

Authors: A. Munoz; Ryan Urak; Ellie Taus; Claire Hsieh; Katherine Jin; Shu-Hong Lin; D. Awuah; Vibhuti Vyas; S. Priceman; Mary C. Clark; S. Forman; Xiuli Wang

Year: 2022

Venue: bioRxiv

DOI: https://doi.org/10.1101/2022.08.29.505735

Paper Engineering chimeric antigen receptor-T cells for cancer treatment

Ye, Baixin; Stary, Creed M.; Li, Xuejun et al. · 2018 · Molecular Cancer · DOI

Full title: Engineering chimeric antigen receptor-T cells for cancer treatment

Authors: Ye, Baixin; Stary, Creed M.; Li, Xuejun; Qingping, Gao; Kang, Chunsheng; Xiong, Xiaoxing

Year: 2018

Venue: Molecular Cancer

DOI: https://doi.org/10.1186/s12943-018-0814-0

Paper T-cell receptor-based therapy: an innovative therapeutic approach for solid tumors

Tsimberidou, Apostolia M.; Morris, Karlyle Van; Vo, Henry Hiep et al. · 2021 · Journal of Hematology & Oncology · DOI

Full title: T-cell receptor-based therapy: an innovative therapeutic approach for solid tumors

Authors: Tsimberidou, Apostolia M.; Morris, Karlyle Van; Vo, Henry Hiep; Eck, Stephen; Lin, Yu‐Feng; Rivas, Jorge Mauricio; Andersson, Börje S.

Year: 2021

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-021-01115-0

Paper IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblasts

Eynde, Astrid Van den; Gehrcken, Laura; Verhezen, Tias et al. · 2024 · Journal of Hematology & Oncology · DOI

Full title: IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblasts

Authors: Eynde, Astrid Van den; Gehrcken, Laura; Verhezen, Tias; Lau, Ho Wa; Hermans, Christophe; Lambrechts, Hilde; Flieswasser, Tal; Quatannens, Delphine; Roex, Gils; Zwaenepoel, Karen; Marcq, Elly; Joye, Philippe; Hoz, Edgar Cardenas De La; Deben, Christophe; Gasparini, Alessia; Montay‐Gruel, Pierre; Compte, Maxim Le; Lion, Eva; Lardon, Filip; Laere, Steven Van; Siozopoulou, Vasiliki; Campillo-Davó, Diana; Waele, Jorrit De; Pauwels, Patrick; Jacobs, Julie; Smits, Evelien; Audenaerde, Jonas R.M. Van

Year: 2024

Venue: Journal of Hematology & Oncology

DOI: https://doi.org/10.1186/s13045-024-01525-w

Paper Redirecting Specificity of T cells Using the Sleeping Beauty System to Express Chimeric Antigen Receptors by Mix-and-Matching of VL and VH Domains Targeting CD123+ Tumors

Thokala, Radhika; Olivares, Simon; Mi, Tiejuan et al. · 2016 · PLoS ONE · DOI

Full title: Redirecting Specificity of T cells Using the Sleeping Beauty System to Express Chimeric Antigen Receptors by Mix-and-Matching of VL and VH Domains Targeting CD123+ Tumors

Authors: Thokala, Radhika; Olivares, Simon; Mi, Tiejuan; Maiti, Sourindra N.; Deniger, Drew C.; Huls, Helen; Torikai, Hiroki; Singh, Harjeet; Champlin, Richard E.; Laskowski, Tamara; McNamara, George; Cooper, Laurence J.N.

Year: 2016

Venue: PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0159477

Paper Scalable CAR-T production in a 2-litre perfusion stirred-tank bioreactor with automated harvesting and scale-down model characterisation.

Springuel, Pierre; Silva Couto, Pedro; Stibbs, Dale J et al. · 2025 · Frontiers in bioengineering and biotechnology · DOI

Full title: Scalable CAR-T production in a 2-litre perfusion stirred-tank bioreactor with automated harvesting and scale-down model characterisation.

Authors: Springuel, Pierre; Silva Couto, Pedro; Stibbs, Dale J; Szelwicki, Michal; Frangleton, Amanda; Schmidberger, Timo; George, Ajith; Slingsby, Fern; Bevan, Nicola; Ahmad, Asma; Legmann, Rachel; Dianat, Noushin; Ladi, Rukmini; Hengst, Julia; Rafiq, Qasim A

Year: 2025

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2025.1694134

Paper CAR T Cell Therapy of Non-hematopoietic Malignancies: Detours on the Road to Clinical Success

Long, Kristen B.; Young, Regina M.; Boesteanu, Alina C. et al. · 2018 · Frontiers in Immunology · DOI

Full title: CAR T Cell Therapy of Non-hematopoietic Malignancies: Detours on the Road to Clinical Success

Authors: Long, Kristen B.; Young, Regina M.; Boesteanu, Alina C.; Davis, Megan M.; Melenhorst, J. Joseph; Lacey, Simon F.; Degaramo, David; Levine, Bruce L.; Fraietta, Joseph A.

Year: 2018

Venue: Frontiers in Immunology

DOI: https://doi.org/10.3389/fimmu.2018.02740

Thesis Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Zhang, Liang · 2020 · KTH Royal Institute of Technology · DOI

Full title: Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Authors: Zhang, Liang

Year: 2020

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-273343

Thesis A systematic review of decision-support tools for regenerative medicine

Lam, Ching; Meinert, Edward; Alturkistani, Abrar et al. · 2019 · Imperial College London · DOI

Full title: A systematic review of decision-support tools for regenerative medicine

Authors: Lam, Ching; Meinert, Edward; Alturkistani, Abrar; Carter, Alison; Karp, Jeffery; Yang, Aidong; Brindley, David; Zhanfeg, Cui

Year: 2019

Venue: Imperial College London

DOI: https://www.jmir.org/2018/12/e12448/

Thesis In-vitro Glioblastoma Treatment Focusing on Convection Enhanced Delivery

Brocke, Conner Ethan · 2022 · Virginia Tech - VTechWorks · DOI

Full title: In-vitro Glioblastoma Treatment Focusing on Convection Enhanced Delivery

Authors: Brocke, Conner Ethan

Year: 2022

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/110333

Thesis The S enantiomer of 2-hydroxyglutarate increases central memory CD8 populations and improves CAR-T therapy outcome.

Foskolou, Iosifina P; Barbieri, Laura; Vernet, Aude et al. · 2023 · University of Cambridge · DOI

Full title: The S enantiomer of 2-hydroxyglutarate increases central memory CD8 populations and improves CAR-T therapy outcome.

Authors: Foskolou, Iosifina P; Barbieri, Laura; Vernet, Aude; Bargiela, David; Cunha, Pedro P; Velica, Pedro; Suh, Eunyeong; Pietsch, Sandra; Matuleviciute, Rugile; Rundqvist, Helene; McIntyre, Dominick; Smith, Ken GC; Johnson, Randall S

Year: 2023

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/347600

Thesis Computational Fluid Dynamics Simulations of Single-Use Bioreactors for the Scale-Up of Cell Culture Processes

Kreitmayer, Diana · 2022 · Heidelberg University · DOI

Full title: Computational Fluid Dynamics Simulations of Single-Use Bioreactors for the Scale-Up of Cell Culture Processes

Authors: Kreitmayer, Diana

Year: 2022

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/32116/1/DissertationDianaKreitmayer.pdf

Thesis Advancing Cell Culture Engineering Through Mechanistic Model Optimization

O'Brien, Conor · 2020 · University of Minnesota - Digital Conservancy · DOI

Full title: Advancing Cell Culture Engineering Through Mechanistic Model Optimization

Authors: O'Brien, Conor

Year: 2020

Venue: University of Minnesota - Digital Conservancy

DOI: http://hdl.handle.net/11299/215059

Thesis Development of Biomaterials for Chimeric Antigen Receptor (CAR) T Cell Therapy

Olden, Brynn · 2018 · University of Washington - ResearchWorks · DOI

Full title: Development of Biomaterials for Chimeric Antigen Receptor (CAR) T Cell Therapy

Authors: Olden, Brynn

Year: 2018

Venue: University of Washington - ResearchWorks

DOI: http://hdl.handle.net/1773/42964

Thesis Materials to enable and enhance T-cell immunotherapies

Zhang, Kongyu · 2021 · Harvard University - DASH · DOI

Full title: Materials to enable and enhance T-cell immunotherapies

Authors: Zhang, Kongyu

Year: 2021

Venue: Harvard University - DASH

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37370159

Thesis Optimizing the Efficacy of Adoptive T Cell Transfers and CAR-T Therapies

Liu, Yutong · 2023 · Harvard University - DASH · DOI

Full title: Optimizing the Efficacy of Adoptive T Cell Transfers and CAR-T Therapies

Authors: Liu, Yutong

Year: 2023

Venue: Harvard University - DASH

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37375491

Thesis Effects of Engineered Costimulation on the Function of T Cell Subsets

Boroughs, Angela C. · 2019 · Harvard University - DASH · DOI

Full title: Effects of Engineered Costimulation on the Function of T Cell Subsets

Authors: Boroughs, Angela C.

Year: 2019

Venue: Harvard University - DASH

DOI: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41121316

Thesis Hydrodynamics considerations in cells systems from ocean flow to perfusion cultivation process

Zhan, Caijuan · 2019 · KTH Royal Institute of Technology · DOI

Full title: Hydrodynamics considerations in cells systems from ocean flow to perfusion cultivation process

Authors: Zhan, Caijuan

Year: 2019

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-252023

Thesis Improvement of adoptive T-cell therapy for Cancer

Jin, Chuan · 2016 · Uppsala University · DOI

Full title: Improvement of adoptive T-cell therapy for Cancer

Authors: Jin, Chuan

Year: 2016

Venue: Uppsala University

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-300210

Thesis High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

Zhang, Ye · 2017 · KTH Royal Institute of Technology · DOI

Full title: High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

Authors: Zhang, Ye

Year: 2017

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-207600

Thesis Advanced Process Development in Gene and Cell Therapies

Ladd, Brian · 2025 · KTH Royal Institute of Technology · DOI

Full title: Advanced Process Development in Gene and Cell Therapies

Authors: Ladd, Brian

Year: 2025

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-360154

Thesis CD19-targeting CAR T Cells for Treatment of B Cell Malignancies : From Bench to Bedside

Karlsson, Hannah · 2014 · Uppsala University · DOI

Full title: CD19-targeting CAR T Cells for Treatment of B Cell Malignancies : From Bench to Bedside

Authors: Karlsson, Hannah

Year: 2014

Venue: Uppsala University

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-232638

Thesis TCR engineered T cell therapy from concepts to clinic

Kierkels, G.J.J. · 2019 · Utrecht University · DOI

Full title: TCR engineered T cell therapy from concepts to clinic

Authors: Kierkels, G.J.J.

Year: 2019

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/379914

Thesis Tackling major hurdles in cell therapy translational research: Different products, common challenges

Mfarrej, Bechara · 2019 · Utrecht University · DOI

Full title: Tackling major hurdles in cell therapy translational research: Different products, common challenges

Authors: Mfarrej, Bechara

Year: 2019

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/386445

Thesis Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022 · KTH Royal Institute of Technology · DOI

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

Year: 2022

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis Characterization of the down regulation of antibody production in high cell density perfusion culture

Morrill, Joyce Catherine · 2006 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Characterization of the down regulation of antibody production in high cell density perfusion culture

Authors: Morrill, Joyce Catherine

Year: 2006

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/32602

Thesis Comparison of the growth and monoclonal antibody production of suspended mammalian cells in three perfusion systems

Hufford, Kathy (Kathy E.) · 2008 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Comparison of the growth and monoclonal antibody production of suspended mammalian cells in three perfusion systems

Authors: Hufford, Kathy (Kathy E.)

Year: 2008

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/39921

Thesis Multiphase modelling of tissue growth in dynamic culture conditions

O'Dea, Reuben · 2008 · University of Nottingham · DOI

Full title: Multiphase modelling of tissue growth in dynamic culture conditions

Authors: O'Dea, Reuben

Year: 2008

Venue: University of Nottingham

DOI: https://eprints.nottingham.ac.uk/10446/1/thesis.pdf

Thesis Micro-bioreactor design for Chinese hamster ovary cells

Goh, Shireen · 2013 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Micro-bioreactor design for Chinese hamster ovary cells

Authors: Goh, Shireen

Year: 2013

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/82368

Thesis Continuum modelling of cell growth and nutrient transport in a perfusion bioreactor

Shakeel, Muhammad · 2011 · University of Nottingham · DOI

Full title: Continuum modelling of cell growth and nutrient transport in a perfusion bioreactor

Authors: Shakeel, Muhammad

Year: 2011

Venue: University of Nottingham

DOI: https://eprints.nottingham.ac.uk/11772/1/Final_thesis_2011.pdf

Thesis White-Box Approaches to Cell Culture Media Optimization for Cultivated Meat

O'Neill, Edward N · 2024 · University of California, Davis · DOI

Full title: White-Box Approaches to Cell Culture Media Optimization for Cultivated Meat

Authors: O'Neill, Edward N

Year: 2024

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/9920t5d7

Thesis Mathematical Modelling and Computational Simulation of in vitro Tissue Culture Processes

Hossain, Md Shakhawath · 2015 · University of Saskatchewan - HARVEST · DOI

Full title: Mathematical Modelling and Computational Simulation of in vitro Tissue Culture Processes

Authors: Hossain, Md Shakhawath

Year: 2015

Venue: University of Saskatchewan - HARVEST

DOI: http://hdl.handle.net/10388/ETD-2015-07-2131

Thesis Fibrer-based bioreactor systems in Mammalian cell culture and tissue engineering Human Trophoblast cells /

Ma, Teng · 1999 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Fibrer-based bioreactor systems in Mammalian cell culture and tissue engineering Human Trophoblast cells /

Authors: Ma, Teng

Year: 1999

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1488188894442926

Thesis Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Cosenza, Zachary Anthony · 2022 · University of California, Davis · DOI

Full title: Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Authors: Cosenza, Zachary Anthony

Year: 2022

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/119489fc

Thesis Study of Hydrodynamics Due to Turbulent Mixing in Animal Cell Microcarrier Bioreactors /

Venkat, Raghavan V. · 1995 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Study of Hydrodynamics Due to Turbulent Mixing in Animal Cell Microcarrier Bioreactors /

Authors: Venkat, Raghavan V.

Year: 1995

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1487931512619511

Thesis Vývoj nových postupů léčby B buněčných malignit pomocí imunoterapie založené na geneticky modifikovaných T lymfocytech

Novotná, Natálie · 2023 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Vývoj nových postupů léčby B buněčných malignit pomocí imunoterapie založené na geneticky modifikovaných T lymfocytech

Authors: Novotná, Natálie

Year: 2023

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/185118

Thesis Enhancing Anti-tumor Efficacy and Improving Manufacturing of Chimeric Antigenic Receptor T Cells

Štach, Martin · 2025 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Enhancing Anti-tumor Efficacy and Improving Manufacturing of Chimeric Antigenic Receptor T Cells

Authors: Štach, Martin

Year: 2025

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/195993

Thesis Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission

Bai, Zhiliang; Feng, Bing; McClory, Susan E. et al. · 2025 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission

Authors: Bai, Zhiliang; Feng, Bing; McClory, Susan E.; de Oliveira, Beatriz Coutinho; Diorio, Caroline; Gregoire, Céline; Tao, Bo; Yang, Luojia; Zhao, Ziran; Peng, Lei; Sferruzza, Giacomo; Zhou, Liqun; Zhou, Xiaolei; Kerr, Jessica; Baysoy, Alev; Su, Graham; Yang, Mingyu; Camara, Pablo G.; Chen, Sidi; Tang, Li; June, Carl H.; Melenhorst, J. Joseph; Grupp, Stephan A.; Fan, Rong

Year: 2025

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/243828

Thesis OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up

Tissot, Stéphanie · 2011 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up

Authors: Tissot, Stéphanie

Year: 2011

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/68752

Thesis Characterization of the mechanism of action of spin-filters for animal cell perfusion cultures

Vallez-Chetreanu, Florentina · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Characterization of the mechanism of action of spin-filters for animal cell perfusion cultures

Authors: Vallez-Chetreanu, Florentina

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/224152

Thesis ELUCIDATING MAMMALIAN CELL METABOLISM USING ‘OMICS TO ENHANCE BIOPROCESS CAPABILITIES

Dhara, Venkata Gayatri · 2022 · Johns Hopkins University · DOI

Full title: ELUCIDATING MAMMALIAN CELL METABOLISM USING ‘OMICS TO ENHANCE BIOPROCESS CAPABILITIES

Authors: Dhara, Venkata Gayatri

Year: 2022

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/66775

Thesis FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

Chan, JD; Scheffler, CM; Munoz, I et al. · 2024 · University of Melbourne · DOI

Full title: FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

Authors: Chan, JD; Scheffler, CM; Munoz, I; Sek, K; Lee, JN; Huang, Y-K; Yap, KM; Saw, NYL; Li, J; Chen, AXY; Chan, CW; Derrick, EB; Todd, KL; Tong, J; Dunbar, PA; Li, J; Hoang, TX; de Menezes, MN; Petley, EV; Kim, JS; Nguyen, D; Leung, PSK; So, J; Deguit, C; Zhu, J; House, IG; Kats, LM; Scott, AM; Solomon, BJ; Harrison, SJ; Oliaro, J; Parish, IA; Quinn, KM; Neeson, PJ; Slaney, CY; Lai, J; Beavis, PA; Darcy, PK

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/345521

Thesis Optimization of chimeric antigen receptor (CAR) therapy

Fräßle, Simon Paul · 2021 · Technical University of Munich (TUM) · DOI

Full title: Optimization of chimeric antigen receptor (CAR) therapy

Authors: Fräßle, Simon Paul

Year: 2021

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1546230

Thesis Expansion of human induced pluripotent stem cells (hiPSCs) in 3D bioreactors for extracorporeal liver support

Greuel, Selina · 2020 · Freie Universität Berlin (Refubium) · DOI

Full title: Expansion of human induced pluripotent stem cells (hiPSCs) in 3D bioreactors for extracorporeal liver support

Authors: Greuel, Selina

Year: 2020

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/26868

Thesis The non-viral production of Chimeric Antigen Receptor T-cells for B-cell haematological malignancies

Dubosq, Ming-Celine · 2020 · University of Sydney · DOI

Full title: The non-viral production of Chimeric Antigen Receptor T-cells for B-cell haematological malignancies

Authors: Dubosq, Ming-Celine

Year: 2020

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/23170

Thesis CD19 specific chimeric antigen receptor expression optimisation in human T-cells using the piggyBac transposase system

Bilmon, Ian Andrew · 2015 · University of Sydney · DOI

Full title: CD19 specific chimeric antigen receptor expression optimisation in human T-cells using the piggyBac transposase system

Authors: Bilmon, Ian Andrew

Year: 2015

Venue: University of Sydney

DOI: http://hdl.handle.net/2123/14060

Thesis Cultivo de celulas hematopeyeticas humanas suspendidasen reactores instrumentados : utilidad de la velocidad de consumo de oxigeno y el potencial redox

Leon Rodriguez, Antonio de · 2021 · Universidad Nacional Autónoma de México (UNAM) · DOI

Full title: Cultivo de celulas hematopeyeticas humanas suspendidasen reactores instrumentados : utilidad de la velocidad de consumo de oxigeno y el potencial redox

Authors: Leon Rodriguez, Antonio de

Year: 2021

Venue: Universidad Nacional Autónoma de México (UNAM)

DOI: https://hdl.handle.net/20.500.14330/TES01000273766

Thesis Development of a prototype hollow fibre bioreactor system

Camacho, Fernando · 1998 · UNSW Sydney · DOI

Full title: Development of a prototype hollow fibre bioreactor system

Authors: Camacho, Fernando

Year: 1998

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/57319

Thesis Vesículas extracelulares derivadas de células CAR-T: produção e caracterização em modelos experimentais e clínicos

Corveloni, Amanda Cristina · 2025 · Universidade de São Paulo – BDTD · DOI

Full title: Vesículas extracelulares derivadas de células CAR-T: produção e caracterização em modelos experimentais e clínicos

Authors: Corveloni, Amanda Cristina

Year: 2025

Venue: Universidade de São Paulo – BDTD

DOI: https://www.teses.usp.br/teses/disponiveis/17/17153/tde-03112025-171718/

Thesis Ex vivo expansion of haematopoietic stem cells in a HFBR

Doran, Michael · 2006 · UNSW Sydney · DOI

Full title: Ex vivo expansion of haematopoietic stem cells in a HFBR

Authors: Doran, Michael

Year: 2006

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/100312

Thesis Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo

Picanço-Castro, Virgínia · 2023 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo

Authors: Picanço-Castro, Virgínia

Year: 2023

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.3389/fimmu.2023.1226518

Thesis Otimização de uma plataforma baseada na edição gênica por CRISPR/Cas9 para a produção de células T alogênicas expressando o receptor quimérico de antígeno (CAR)

Souza, Lucas Eduardo Botelho · 2024 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Otimização de uma plataforma baseada na edição gênica por CRISPR/Cas9 para a produção de células T alogênicas expressando o receptor quimérico de antígeno (CAR)

Authors: Souza, Lucas Eduardo Botelho

Year: 2024

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.11606/D.17.2024.tde-13052024-144054

Thesis Cytokines as an important player in the context of CAR-T cell therapy for cancer: their role in tumor immunomodulation, manufacture, and clinical implications

Guerino-Cunha, Renato Luiz · 2022 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Cytokines as an important player in the context of CAR-T cell therapy for cancer: their role in tumor immunomodulation, manufacture, and clinical implications

Authors: Guerino-Cunha, Renato Luiz

Year: 2022

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.3389/fimmu.2022.947648

Thesis Adoptive T Cell Therapy for Treatment of Metastatic Melanoma

Sadeghi, Arian · 2011 · Uppsala University · DOI

Full title: Adoptive T Cell Therapy for Treatment of Metastatic Melanoma

Authors: Sadeghi, Arian

Year: 2011

Venue: Uppsala University

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-143698

Thesis GMP-grade manufacturing of T cells engineered to express a defined γδTCR

Straetemans, Trudy; Kierkels, Guido J.J.; Doorn, Ruud et al. · 2018 · Utrecht University · DOI

Full title: GMP-grade manufacturing of T cells engineered to express a defined γδTCR

Authors: Straetemans, Trudy; Kierkels, Guido J.J.; Doorn, Ruud; Jansen, Koen; Heijhuurs, Sabine; dos Santos, Joao M.; van Muyden, Anna D.D.; Vie, Henri; Clemenceau, Béatrice; Raymakers, Reinier; de Witte, Moniek; Sebestyén, Zsolt; Kuball, Jürgen

Year: 2018

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/365453

Thesis Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

Wachsmann, Tassilo L A; Wouters, Anne K; Remst, Dennis F G et al. · 2022 · Utrecht University · DOI

Full title: Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

Authors: Wachsmann, Tassilo L A; Wouters, Anne K; Remst, Dennis F G; Hagedoorn, Renate S; Meeuwsen, Miranda H; van Diest, Eline; Leusen, Jeanette; Kuball, Jürgen; Falkenburg, J H Frederik; Heemskerk, Mirjam H M

Year: 2022

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/445619

Thesis Regulatory perspective on in vitro potency assays for human T cells used in anti-tumor immunotherapy

de Wolf, Charlotte; van de Bovenkamp, Marja; Hoefnagel, Marcel C · 2018 · Utrecht University · DOI

Full title: Regulatory perspective on in vitro potency assays for human T cells used in anti-tumor immunotherapy

Authors: de Wolf, Charlotte; van de Bovenkamp, Marja; Hoefnagel, Marcel C

Year: 2018

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/376475

Thesis Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe et al. · 2016 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

Authors: López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe; Carrillo-Cocom, Leydi Maribel; Rocha-Pizaña, María del Refugio; Alvarez, Mario Moises

Year: 2016

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/105504

Thesis Rapid tissue prototyping with micro-organospheres

Wang, Zhaohui; Boretto, Matteo; Millen, Rosemary et al. · 2022 · Utrecht University · DOI

Full title: Rapid tissue prototyping with micro-organospheres

Authors: Wang, Zhaohui; Boretto, Matteo; Millen, Rosemary; Natesh, Naveen; Reckzeh, Elena S.; Hsu, Carolyn; Negrete, Marcos; Yao, Haipei; Quayle, William; Heaton, Brook E.; Harding, Alfred T.; Bose, Shree; Driehuis, Else; Beumer, Joep; Rivera, Grecia O.; van Ineveld, Ravian L.; Gex, Donald; DeVilla, Jessica; Wang, Daisong; Puschhof, Jens; Geurts, Maarten H.; Yeung, Athena; Hamele, Cait; Smith, Amber; Bankaitis, Eric; Xiang, Kun; Ding, Shengli; Nelson, Daniel; Delubac, Daniel; Rios, Anne; Abi-Hachem, Ralph; Jang, David; Goldstein, Bradley J.; Glass, Carolyn; Heaton, Nicholas S.; Hsu, David; Clevers, Hans; Shen, Xiling

Year: 2022

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/447775

Thesis Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

Tang, Li; Zheng, Yiran; Melo, Mariane Bandeira et al. · 2019 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

Authors: Tang, Li; Zheng, Yiran; Melo, Mariane Bandeira; Mabardi, Llian; Castaño, Ana P; Xie, Yu-Qing; Li, Na; Kudchodkar, Sagar B; Wong, Hing C; Jeng, Emily K; Maus, Marcela V; Irvine, Darrell J

Year: 2019

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/120102

Thesis Billion-Scale Expansion of Functional hiPSC-Derived Cardiomyocytes in Bioreactors Through Oxygen Control and Continuous Wnt Activation

Vicente, Pedro; Inocêncio, Lara R.; Ullate-Agote, Asier et al. · 2025 · Utrecht University · DOI

Full title: Billion-Scale Expansion of Functional hiPSC-Derived Cardiomyocytes in Bioreactors Through Oxygen Control and Continuous Wnt Activation

Authors: Vicente, Pedro; Inocêncio, Lara R.; Ullate-Agote, Asier; Louro, Ana F.; Jacinto, João; Gamelas, Beatriz; Iglesias-García, Olalla; Martin-Uriz, Patxi San; Aguirre-Ruiz, Paula; Ríos-Muñoz, Gonzalo R.; Fernández-Santos, María Eugenia; van Mil, Alain; Sluijter, Joost P.G.; Prósper, Felipe; Vega, Manuel M.Mazo; Alves, Paula M.; Serra, Margarida

Year: 2025

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/460379

Thesis Biomanufacturing for clinically advanced cell therapies

Aijaz, Ayesha; Li, Matthew; Smith, David et al. · 2019 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Biomanufacturing for clinically advanced cell therapies

Authors: Aijaz, Ayesha; Li, Matthew; Smith, David; Khong, Danika; LeBlon, Courtney; Olabisi, Ronke M.; Libutti, Steven; Tischfield, Jay; Maus, Marcela V.; Deans, Robert; Barcia, Rita N.; Anderson, Daniel Griffith; Ritz, Jerome; Preti, Robert; Parekkadan, Biju; Fenton, Owen Shea

Year: 2019

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/121979

Thesis Sense-and-Respond Payload Delivery Using a Novel Antigen-Inducible Promoter Improves Suboptimal CAR-T Activation

Guo, Tingxi; Ma, Dacheng; Lu, Timothy K · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Sense-and-Respond Payload Delivery Using a Novel Antigen-Inducible Promoter Improves Suboptimal CAR-T Activation

Authors: Guo, Tingxi; Ma, Dacheng; Lu, Timothy K

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/143767

Thesis Miniature auto‐perfusion bioreactor system with spiral microfluidic cell retention device

Yin, Lu; Au, Wen Y.; Yu, Chia C. et al. · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Miniature auto‐perfusion bioreactor system with spiral microfluidic cell retention device

Authors: Yin, Lu; Au, Wen Y.; Yu, Chia C.; Kwon, Taehong; Lai, Zhangxing; Shang, Menglin; Warkiani, Majid E.; Rosche, Roger; Lim, Chwee T.; Han, Jongyoon

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/140309.2

Thesis A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

Boroughs, Angela C; Larson, Rebecca C; Marjanovic, Nemanja D et al. · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

Authors: Boroughs, Angela C; Larson, Rebecca C; Marjanovic, Nemanja D; Gosik, Kirk; Castano, Ana P; Porter, Caroline BM; Lorrey, Selena J; Ashenberg, Orr; Jerby, Livnat; Hofree, Matan; Smith-Rosario, Gabriela; Morris, Robert; Gould, Joshua; Riley, Lauren S; Berger, Trisha R; Riesenfeld, Samantha J; Rozenblatt-Rosen, Orit; Choi, Bryan D; Regev, Aviv; Maus, Marcela V

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/147057

Thesis Transport and shear in a microfluidic membrane bilayer device for cell culture

Inamdar, Niraj K.; Griffith, Linda G.; Borenstein, Jeffrey T. · 2012 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Transport and shear in a microfluidic membrane bilayer device for cell culture

Authors: Inamdar, Niraj K.; Griffith, Linda G.; Borenstein, Jeffrey T.

Year: 2012

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/75775

Thesis Transport Model for Microfluidic Device for Cell Culture and Tissue Development

Inamdar, Niraj K.; Griffith, Linda G.; Borenstein, Jeffrey T. · 2013 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Transport Model for Microfluidic Device for Cell Culture and Tissue Development

Authors: Inamdar, Niraj K.; Griffith, Linda G.; Borenstein, Jeffrey T.

Year: 2013

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/76193

Thesis Qualitatively Different T Cell Phenotypic Responses to IL-2 versus IL-15 Are Unified by Identical Dependences on Receptor Signal Strength and Duration

Arneja, Abhinav; Johnson, Hannah; Gabrovsek, Laura et al. · 2015 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Qualitatively Different T Cell Phenotypic Responses to IL-2 versus IL-15 Are Unified by Identical Dependences on Receptor Signal Strength and Duration

Authors: Arneja, Abhinav; Johnson, Hannah; Gabrovsek, Laura; White, Forest M.; Lauffenburger, Douglas A

Year: 2015

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/99480

Thesis New Strategy for Promoting Vascularization in Tumor Spheroids in a Microfluidic Assay

Wan, Zhengpeng; Floryan, Marie A; Coughlin, Mark F et al. · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: New Strategy for Promoting Vascularization in Tumor Spheroids in a Microfluidic Assay

Authors: Wan, Zhengpeng; Floryan, Marie A; Coughlin, Mark F; Zhang, Shun; Zhong, Amy X; Shelton, Sarah E; Wang, Xun; Xu, Chenguang; Barbie, David A; Kamm, Roger D

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/148045

Thesis Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel et al. · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Authors: Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel; Dang, Brendan; Wolffe, Lenna A; Atari, Adel; Tseng, Yuen-Yi; Love, J Christopher

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/163220

Thesis Understanding T cell phenotype for the design of effective chimeric antigen receptor T cell therapies

Tantalo, DGM; Oliver, AJ; Von Scheidt, B et al. · 2021 · University of Melbourne · DOI

Full title: Understanding T cell phenotype for the design of effective chimeric antigen receptor T cell therapies

Authors: Tantalo, DGM; Oliver, AJ; Von Scheidt, B; Harrison, AJ; Mueller, SN; Kershaw, MH; Slaney, CY

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/278368

Thesis Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture

Shariatzadeh, M; Lopes, AG; Glen, KE et al. · 2021 · University of Melbourne · DOI

Full title: Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture

Authors: Shariatzadeh, M; Lopes, AG; Glen, KE; Sinclair, A; Thomas, RJ

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/289743

Thesis Predictions for optimal mitigation of paracrine inhibitory signalling in haemopoietic stem cell cultures

Berry, JD; Godara, P; Liovic, P et al. · 2018 · University of Melbourne · DOI

Full title: Predictions for optimal mitigation of paracrine inhibitory signalling in haemopoietic stem cell cultures

Authors: Berry, JD; Godara, P; Liovic, P; Haylock, DN

Year: 2018

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/208852

Thesis Manufacturing T cells in hollow fiber membrane bioreactors changes their programming and enhances their potency

Yoo, SM; Lau, VWC; Aarts, C et al. · 2022 · University of Melbourne · DOI

Full title: Manufacturing T cells in hollow fiber membrane bioreactors changes their programming and enhances their potency

Authors: Yoo, SM; Lau, VWC; Aarts, C; Bojovic, B; Steinberg, G; Hammill, JA; Dvorkin-Gheva, A; Ghosh, R; Bramson, JL

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/305190

Thesis CD4+ chimeric antigen receptor T cells in for the long journey

Chen, AXY; Derrick, EB; Beavis, PA et al. · 2023 · University of Melbourne · DOI

Full title: CD4+ chimeric antigen receptor T cells in for the long journey

Authors: Chen, AXY; Derrick, EB; Beavis, PA; House, IG

Year: 2023

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/336424

Thesis EARLY-PHENOTYPE LEWIS Y CAR-T CELLS PERSIST BETTER IN VIVO AND INDUCE SOLID TUMOR REGRESSION IN COMBINATION WITH ANTI-PD1

Meyran, D; Zhu, J; Butler, J et al. · 2021 · University of Melbourne · DOI

Full title: EARLY-PHENOTYPE LEWIS Y CAR-T CELLS PERSIST BETTER IN VIVO AND INDUCE SOLID TUMOR REGRESSION IN COMBINATION WITH ANTI-PD1

Authors: Meyran, D; Zhu, J; Butler, J; Macdonald, S; Tantalo, D; Thio, N; Sek, K; Ekert, P; Kershaw, M; Trapani, J; Darcy, P; Neeson, P

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/273975

Thesis IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors

Giuffrida, L; Sek, K; Henderson, MA et al. · 2023 · University of Melbourne · DOI

Full title: IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors

Authors: Giuffrida, L; Sek, K; Henderson, MA; House, IG; Lai, J; Chen, AXY; Todd, KL; Petley, EV; Mardiana, S; Todorovski, I; Gruber, E; Kelly, MJ; Solomon, BJ; Vervoort, SJ; Johnstone, RW; Parish, IA; Neeson, PJ; Kats, LM; Darcy, PK; Beavis, PA

Year: 2023

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/331896

Thesis Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain

Vorri, SC; Holl, NJ; Leeming, M et al. · 2025 · University of Melbourne · DOI

Full title: Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain

Authors: Vorri, SC; Holl, NJ; Leeming, M; Apostolova, P; Marple, A; Ravich, JW; Canbaz, A; Rahnama, R; Choe, J; Modi, A; Fearnow, AD; Walsh, STR; Pearce, EL; Varadhan, R; Bonifant, CL

Year: 2025

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/358519

Thesis MECHANOCULTURE – Applications of dynamic pressure in manufacturing cell therapies

Hallas, Joe; Al-Maslemani, Noor; Janvier, Adam et al. · 2019 · University of Liverpool · DOI

Full title: MECHANOCULTURE – Applications of dynamic pressure in manufacturing cell therapies

Authors: Hallas, Joe; Al-Maslemani, Noor; Janvier, Adam; Hoettges, Kai; Henstock, James

Year: 2019

Venue: University of Liverpool

DOI: https://livrepository.liverpool.ac.uk/3071579/1/James%20Henstock%20mechanoculture%20TERMIS%20AP.pdf

Thesis Generation of stable suspension producer cell lines for serum-free lentivirus production

Klimpel, M; Terrao, M; Bräuer, M et al. · 2024 · University of Melbourne · DOI

Full title: Generation of stable suspension producer cell lines for serum-free lentivirus production

Authors: Klimpel, M; Terrao, M; Bräuer, M; Dersch, H; Biserni, M; Melo Do Nascimento, L; Schwingal, S; Vogel, JE; Ferlemann, C; Brandt, T; Lal, NI; Bridgeman, K; Petzke, A; McDwyer, E; Lim, JL; Oh, S; Brumatti, G; Garcia Minambres, A; Otte, E; Noll, T; Pirzas, V; Laux, H

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/351064

Thesis A Perfusion Bioreactor System for Cell Seeding and Oxygen-Controlled Cultivation of Three-Dimensional Cell Cultures

Schmid, Jakob; Schwarz, Sascha; Meier-Staude, Robert et al. · 2018 · Technical University of Munich (TUM) · DOI

Full title: A Perfusion Bioreactor System for Cell Seeding and Oxygen-Controlled Cultivation of Three-Dimensional Cell Cultures

Authors: Schmid, Jakob;Schwarz, Sascha;Meier-Staude, Robert;Sudhop, Stefanie;Clausen-Schaumann, Hauke;Schieker, Matthias;Huber, Robert

Year: 2018

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1525549

Thesis Optimization of Fermentation and Freeze-Drying Processes to Enhance the Productivity and Stability of a Probiotic, Lactobacillus Salivarius I 24

Lim, Chin Ming · 2006 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Optimization of Fermentation and Freeze-Drying Processes to Enhance the Productivity and Stability of a Probiotic, Lactobacillus Salivarius I 24

Authors: Lim, Chin Ming

Year: 2006

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/5354/1/IB_2006_10.pdf

Thesis MODEL COMPARISON TO DESCRIBE BHK-21 CELL GROWTH AND METABOLISM IN STIRRED TANK BIOREACTORS OPERATED IN BATCH MODE

Sartori, Roger [UNESP]; Leme, Jaci; Caricati, Celso Pereira et al. · 2019 · Universidade Estadual Paulista (UNESP) · DOI

Full title: MODEL COMPARISON TO DESCRIBE BHK-21 CELL GROWTH AND METABOLISM IN STIRRED TANK BIOREACTORS OPERATED IN BATCH MODE

Authors: Sartori, Roger [UNESP]; Leme, Jaci; Caricati, Celso Pereira; Tonso, Aldo; Fernandez Nunez, Eutimio Gustavo [UNESP]

Year: 2019

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1590/0104-6632.20180352s20160592

Thesis Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing

Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP] et al. · 2019 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing

Authors: Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP]; Deffune, Elenice; Suazo, Cláudio Alberto Torres

Year: 2019

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1590/0104-6632.20180352s20160463

Thesis 3D Systems for Immune cells culture and their applications in Immunotherapy

Pérez del Río, Eduardo · 2020 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: 3D Systems for Immune cells culture and their applications in Immunotherapy

Authors: Pérez del Río, Eduardo

Year: 2020

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/670158

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Full title: us-2021161961-a1

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Full title: us-2021128623-a1

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· 2021

Full title: us-2021128624-a1

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· 2021

Full title: us-2021139935-a1

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· 2021

Full title: us-2021137984-a1

Year: 2021

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· 2021

Full title: us-2021161963-a1

Year: 2021

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· 2021

Full title: us-2021148895-a1

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· 2021

Full title: us-2021236547-a1

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· 2021

Full title: us-2021207092-a1

Year: 2021

Patent us-2021220403-a1

· 2021

Full title: us-2021220403-a1

Year: 2021

Patent us-2021163893-a1

· 2021

Full title: us-2021163893-a1

Year: 2021

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· 2021

Full title: us-2021207091-a1

Year: 2021

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· 2021

Full title: us-2021169933-a1

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· 2021

Full title: us-2021214682-a1

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· 2021

Full title: us-2021230547-a1

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· 2021

Full title: us-2021230532-a1

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· 2021

Full title: us-2021246423-a1

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· 2021

Full title: us-2021214723-a1

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· 2021

Full title: us-2021214685-a1

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· 2021

Full title: us-2021254000-a1

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· 2021

Full title: us-2021244871-a1

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· 2021

Full title: us-2021315198-a1

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· 2021

Full title: us-2021309712-a1

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· 2021

Full title: us-2021355420-a1

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· 2021

Full title: us-2021299223-a1

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· 2021

Full title: us-2021317181-a1

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· 2021

Full title: us-2021353677-a1

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· 2021

Full title: us-2021401890-a1

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· 2021

Full title: us-2021361713-a1

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· 2021

Full title: us-2021361712-a1

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· 2021

Full title: us-2021361709-a1

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· 2022

Full title: us-2022016167-a1

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· 2022

Full title: us-2022000923-a1

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· 2022

Full title: us-2022000921-a1

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· 2021

Full title: us-2021379111-a1

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· 2022

Full title: us-2022064305-a1

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· 2022

Full title: us-2022008469-a1

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Patent us-2022000925-a1

· 2022

Full title: us-2022000925-a1

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· 2022

Full title: us-2022010278-a1

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Patent us-2022000924-a1

· 2022

Full title: us-2022000924-a1

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Patent us-2022040229-a1

· 2022

Full title: us-2022040229-a1

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· 2022

Full title: us-2022096546-a1

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· 2022

Full title: us-2022025329-a1

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· 2022

Full title: us-2022090018-a1

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· 2022

Full title: us-2022064597-a1

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· 2022

Full title: us-2022135921-a1

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· 2022

Full title: us-2022096549-a1

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· 2022

Full title: us-2022118011-a1

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· 2022

Full title: us-2022125656-a1

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· 2022

Full title: us-2022047677-a1

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· 2022

Full title: us-2022125836-a1

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· 2022

Full title: us-2022133801-a1

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· 2022

Full title: us-2022177841-a1

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· 2022

Full title: us-2022133795-a1

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· 2022

Full title: us-2022177839-a1

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· 2022

Full title: us-2022168389-a1

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· 2022

Full title: us-2022177821-a1

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· 2022

Full title: us-2022168442-a1

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· 2022

Full title: us-2022152107-a1

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· 2022

Full title: us-2022282213-a1

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· 2022

Full title: us-2022266214-a1

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· 2022

Full title: us-2022235305-a1

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· 2022

Full title: us-2022228101-a1

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· 2022

Full title: us-2022193134-a1

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· 2022

Full title: us-2022193131-a1

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· 2022

Full title: us-2022282212-a1

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· 2022

Full title: us-2022288121-a1

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· 2022

Full title: us-2022289820-a1

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Patent us-2022282214-a1

· 2022

Full title: us-2022282214-a1

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· 2022

Full title: us-2022306977-a1

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Patent us-2025255906-a1

· 2025

Full title: us-2025255906-a1

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· 2025

Full title: us-2025250541-a1

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Patent us-2025230217-a1

· 2025

Full title: us-2025230217-a1

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Patent us-2025215096-a1

· 2025

Full title: us-2025215096-a1

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Patent us-2025302957-a1

· 2025

Full title: us-2025302957-a1

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Patent us-2025263661-a1

· 2025

Full title: us-2025263661-a1

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Patent us-2025297219-a1

· 2025

Full title: us-2025297219-a1

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Patent us-2025257138-a1

· 2025

Full title: us-2025257138-a1

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Patent us-2025282845-a1

· 2025

Full title: us-2025282845-a1

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Patent us-2025281537-a1

· 2025

Full title: us-2025281537-a1

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Patent us-6645490-b2

· 2003

Full title: us-6645490-b2

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· 2025

Full title: us-2025276016-a1

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· 2025

Full title: us-2025313608-a1

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Patent us-9487800-b2

· 2016

Full title: us-9487800-b2

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Patent us-2025327010-a1

· 2025

Full title: us-2025327010-a1

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Patent us-9114100-b2

· 2015

Full title: us-9114100-b2

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Patent us-2025145951-a1

· 2025

Full title: us-2025145951-a1

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Patent us-2022265708-a1

· 2022

Full title: us-2022265708-a1

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· 2022

Full title: us-2022354972-a1

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Patent us-2022339193-a1

· 2022

Full title: us-2022339193-a1

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· 2022

Full title: us-2022387494-a1

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· 2022

Full title: us-2022378838-a1

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Patent us-2022387493-a1

· 2022

Full title: us-2022387493-a1

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· 2022

Full title: us-2022325240-a1

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· 2022

Full title: us-2022387495-a1

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Patent us-2022325245-a1

· 2022

Full title: us-2022325245-a1

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Patent us-2022362301-a1

· 2022

Full title: us-2022362301-a1

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Patent us-2022387496-a1

· 2022

Full title: us-2022387496-a1

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Patent us-2022389381-a1

· 2022

Full title: us-2022389381-a1

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Patent us-2022389383-a1

· 2022

Full title: us-2022389383-a1

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Patent us-2022389094-a1

· 2022

Full title: us-2022389094-a1

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Patent us-2022387498-a1

· 2022

Full title: us-2022387498-a1

Year: 2022

Patent us-2022403333-a1

· 2022

Full title: us-2022403333-a1

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Patent us-2022387497-a1

· 2022

Full title: us-2022387497-a1

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Patent us-2022396768-a1

· 2022

Full title: us-2022396768-a1

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Patent us-2022395533-a1

· 2022

Full title: us-2022395533-a1

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Patent us-2022364055-a1

· 2022

Full title: us-2022364055-a1

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Patent us-2022396769-a1

· 2022

Full title: us-2022396769-a1

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Patent us-2022387499-a1

· 2022

Full title: us-2022387499-a1

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Patent us-2022401476-a1

· 2022

Full title: us-2022401476-a1

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Patent us-2023012086-a1

· 2023

Full title: us-2023012086-a1

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Patent us-2023000913-a1

· 2023

Full title: us-2023000913-a1

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Patent us-2022403334-a1

· 2022

Full title: us-2022403334-a1

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Patent us-2023013765-a1

· 2023

Full title: us-2023013765-a1

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Patent us-2022401479-a1

· 2022

Full title: us-2022401479-a1

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Patent us-2023032934-a1

· 2023

Full title: us-2023032934-a1

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Patent us-2023021312-a1

· 2023

Full title: us-2023021312-a1

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Patent us-2023028668-a1

· 2023

Full title: us-2023028668-a1

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· 2023

Full title: us-2023012496-a1

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Patent us-2023030481-a1

· 2023

Full title: us-2023030481-a1

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· 2023

Full title: us-2023021572-a1

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Patent us-2023015649-a1

· 2023

Full title: us-2023015649-a1

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Patent us-2023027004-a1

· 2023

Full title: us-2023027004-a1

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· 2023

Full title: us-2023151094-a1

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Patent us-2023045899-a1

· 2023

Full title: us-2023045899-a1

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· 2023

Full title: us-2023019849-a1

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Patent us-2023134345-a1

· 2023

Full title: us-2023134345-a1

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· 2023

Full title: us-2023087125-a1

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· 2023

Full title: us-2023106973-a1

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Patent us-2023039516-a1

· 2023

Full title: us-2023039516-a1

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· 2023

Full title: us-2023172982-a1

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· 2023

Full title: us-2023147832-a1

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Patent us-2023165898-a1

· 2023

Full title: us-2023165898-a1

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· 2023

Full title: us-2023133298-a1

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Patent us-2023190804-a1

· 2023

Full title: us-2023190804-a1

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· 2023

Full title: us-2023193202-a1

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· 2023

Full title: us-2023172987-a1

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· 2023

Full title: us-2023158164-a1

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· 2023

Full title: us-2023242879-a1

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· 2023

Full title: us-2023220103-a1

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· 2023

Full title: us-2023257705-a1

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· 2023

Full title: us-2023226111-a1

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· 2023

Full title: us-2023295296-a1

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Full title: us-2023242654-a1

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· 2023

Full title: us-2023279352-a1

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· 2023

Full title: us-2023322923-a1

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· 2023

Full title: us-2023265147-a1

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· 2023

Full title: us-2023313107-a1

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· 2023

Full title: us-2023332105-a1

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Full title: us-2023340052-a1

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Full title: us-2023374433-a1

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· 2023

Full title: us-2023338424-a1

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· 2023

Full title: us-2023340412-a1

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· 2023

Full title: us-2023348548-a1

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· 2023

Full title: us-2023303654-a1

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· 2024

Full title: us-2024009243-a1

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· 2023

Full title: us-2023340385-a1

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· 2023

Full title: us-2023405122-a1

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· 2024

Full title: us-2024018473-a1

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· 2024

Full title: us-2024034802-a1

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· 2023

Full title: us-2023392119-a1

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· 2024

Full title: us-2024018475-a1

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· 2024

Full title: us-2024067724-a1

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Full title: us-2024084255-a1

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· 2024

Full title: us-2024058445-a1

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· 2024

Full title: us-2024024475-a1

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· 2024

Full title: us-2024024360-a1

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· 2024

Full title: us-2024101946-a1

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Full title: us-11866688-b2

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Full title: us-11939562-b2

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Full title: us-11939596-b2

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Full title: us-11904081-b2

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Full title: us-11999969-b2

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Full title: us-12024718-b2

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Full title: us-11970528-b2

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· 2024

Full title: us-11992504-b2

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· 2024

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· 2024

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· 2024

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· 2024

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· 2024

Full title: us-12076344-b2

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· 2024

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Full title: us-12134757-b2

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· 2023

Full title: us-11827902-b2

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Full title: us-12226522-b2

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· 2024

Full title: us-12163153-b2

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· 2025

Full title: us-12226434-b2

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Full title: us-12194061-b2

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· 2025

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· 2025

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· 2025

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· 2024

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· 2024

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· 2025

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· 2025

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· 2025

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· 2025

Full title: us-12391958-b2

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· 2025

Full title: us-12359170-b2

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Full title: us-2014255363-a1

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· 2025

Full title: us-12441787-b2

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Patent us-2013058909-a1

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Full title: us-2013058909-a1

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· 2014

Full title: us-2014050709-a1

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· 2013

Full title: us-2013280221-a1

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· 2015

Full title: us-2015344844-a1

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Full title: us-2016303166-a1

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Full title: us-2017204372-a1

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· 2016

Full title: us-2016333314-a1

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· 2016

Full title: us-2016310532-a1

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· 2017

Full title: us-2017044227-a1

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· 2017

Full title: us-2017136063-a1

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· 2017

Full title: us-2017232070-a1

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· 2018

Full title: us-2018207201-a1

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· 2018

Full title: us-2018282695-a1

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· 2018

Full title: us-2018280436-a1

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Patent us-2018280438-a1

· 2018

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Metadata only

Paper KTE-X19 anti-CD19 CAR T-cell therapy in adult relapsed/refractory acute lymphoblastic leukemia: ZUMA-3 phase 1 results.

Shah, Bijal D; Bishop, Michael R; Oluwole, Olalekan O et al. · 2021 · Blood · DOI

Full title: KTE-X19 anti-CD19 CAR T-cell therapy in adult relapsed/refractory acute lymphoblastic leukemia: ZUMA-3 phase 1 results.

Authors: Shah, Bijal D; Bishop, Michael R; Oluwole, Olalekan O; Logan, Aaron C; Baer, Maria R; Donnellan, William B; O'Dwyer, Kristen M; Holmes, Houston; Arellano, Martha L; Ghobadi, Armin; Pagel, John M; Lin, Yi; Cassaday, Ryan D; Park, Jae H; Abedi, Mehrdad; Castro, Januario E; DeAngelo, Daniel J; Malone, Adriana K; Mawad, Raya; Schiller, Gary J; Rossi, John M; Bot, Adrian; Shen, Tong; Goyal, Lovely; Jain, Rajul K; Vezan, Remus; Wierda, William G

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood.2020009098

Paper Large-Scale Manufacturing of CMV-CD19CAR T Cells and Characterization of Their Biologic and Immunologic Properties

Xiuli Wang; M. Walter; Ryan Urak et al. · 2019 · Blood · DOI

Full title: Large-Scale Manufacturing of CMV-CD19CAR T Cells and Characterization of Their Biologic and Immunologic Properties

Authors: Xiuli Wang; M. Walter; Ryan Urak; Laura Lim; Vibhuti Vyas; S. Mokhtari; D. Diamond; Angelo Cardoso; J. Zaia; S. Forman; R. Nakamura

Year: 2019

Venue: Blood

DOI: https://doi.org/10.1182/blood-2019-131843

Paper Third Generation CD20 Targeted CAR T-Cell Therapy (MB-106) for Treatment of Patients with Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma

M. Shadman; C. Yeung; M. Redman et al. · 2020 · DOI

Full title: Third Generation CD20 Targeted CAR T-Cell Therapy (MB-106) for Treatment of Patients with Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma

Authors: M. Shadman; C. Yeung; M. Redman; S. Lee; D. H. Lee; A. Ramachandran; S. Ra; Edmond A Marzbani; S. Graf; E. Warren; A. Gopal; A. Chapuis; M. Bar; D. Green; J. Gauthier; R. Cassaday; H. Kiem; C. Turtle; D. Maloney; B. Till

Year: 2020

DOI: https://doi.org/10.1182/blood-2020-136440

Paper Successful Manufacturing of CAR T-Cells with Small Volume Peripheral Blood from Healthy Donors Using the Clinimacs Prodigy Device

Katie A. Palen; P. Hari; N. Shah et al. · 2020 · DOI

Full title: Successful Manufacturing of CAR T-Cells with Small Volume Peripheral Blood from Healthy Donors Using the Clinimacs Prodigy Device

Authors: Katie A. Palen; P. Hari; N. Shah; Bryon D. Johnson

Year: 2020

DOI: https://doi.org/10.1182/blood-2020-136795

Paper Developing a Novel Anti-CD19/CD20 Bi-Specific Chimeric Antigen Receptor T (CAR-T) Cell Therapy for Relapsed/Refractory (r/r) B-Cell NHL

Lili Zhou; Jiaqi Huang; Zhu Shigui et al. · 2020 · DOI

Full title: Developing a Novel Anti-CD19/CD20 Bi-Specific Chimeric Antigen Receptor T (CAR-T) Cell Therapy for Relapsed/Refractory (r/r) B-Cell NHL

Authors: Lili Zhou; Jiaqi Huang; Zhu Shigui; X. Yao; Shi-guang Ye; Judy Zhu; C. Zheng; Shi-Yu Chen; Li Yanfeng; L. Lan; Shicheng Chen; Lin Guo; Qingsong Zhang; Jian-hua Zheng; Rirfei Wang; Yinghui Hong; Jiaqiang Ren; Li Zhang; Wenjun Zhang; Xiaochen Tang; Junbang Wang; Jie Liu; M. Humphries; Ping Li; Yihong Yao; A. Liang

Year: 2020

DOI: https://doi.org/10.1182/blood-2020-137826

Paper Single-Cell Cytokine Analysis of LV20.19 Bispecific CAR T-Cell Products from a Phase I Clinical Trial

Huiqing Xu; K. Chaney; Bryon D. Johnson et al. · 2020 · DOI

Full title: Single-Cell Cytokine Analysis of LV20.19 Bispecific CAR T-Cell Products from a Phase I Clinical Trial

Authors: Huiqing Xu; K. Chaney; Bryon D. Johnson; T. Fenske; M. Hamadani; B. Dropulić; D. Schneider; P. Hari; N. Shah

Year: 2020

DOI: https://doi.org/10.1182/blood-2020-136805

Paper Successful 24-Hours Manufacture of Anti-CD19/CD22 Dual Chimeric Antigen Receptor (CAR) T Cell Therapy for B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Jun-fang Yang; Pengfei Jiang; Xian Zhang et al. · 2020 · DOI

Full title: Successful 24-Hours Manufacture of Anti-CD19/CD22 Dual Chimeric Antigen Receptor (CAR) T Cell Therapy for B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Authors: Jun-fang Yang; Pengfei Jiang; Xian Zhang; Jing-jing Li; Yan Wu; Li Xu; Yunchao Su; Xiaona Hu; Xiaoyan Zhao; Qirui Dong; Songbai Cai; Zhenguang Wang; Yuezhang Chen; Xun Ye; Jiaping He; Nanjing Lin; W. Cao; M. Sersch; P. Lu

Year: 2020

DOI: https://doi.org/10.1182/blood-2020-136866

Paper A Phase 1/1b Safety Study of Prgn-3006 Ultracar-T™ in Patients with Relapsed or Refractory CD33-Positive Acute Myeloid Leukemia and Higher Risk Myelodysplastic Syndrome

D. Sallman; H. Elmariah; K. Sweet et al. · 2020 · Blood · DOI

Full title: A Phase 1/1b Safety Study of Prgn-3006 Ultracar-T™ in Patients with Relapsed or Refractory CD33-Positive Acute Myeloid Leukemia and Higher Risk Myelodysplastic Syndrome

Authors: D. Sallman; H. Elmariah; K. Sweet; Chetasi Talati; A. Mishra; L. Kelley; Amy R. Lankford; T. Chan; Rutul R. Shah; E. Padron; R. Komrokji; J. Lancet; H. Sabzevari; M. Davila; N. Bejanyan

Year: 2020

Venue: Blood

DOI: https://doi.org/10.1182/blood-2020-139417

Paper Preclinical Development of Inducible MyD88/CD40 (iMC)-Enhanced Chimeric Antigen Receptor Natural Killer (GoCAR-NK) Cells to Target BCMA+ Tumors

Wang, Xiaomei; Duong, MyLinh; Guerrero, Alan et al. · 2020 · Blood · DOI

Full title: Preclinical Development of Inducible MyD88/CD40 (iMC)-Enhanced Chimeric Antigen Receptor Natural Killer (GoCAR-NK) Cells to Target BCMA+ Tumors

Authors: Wang, Xiaomei; Duong, MyLinh; Guerrero, Alan; Mahendravada, Aruna; Sharp, Kelly; Brandt, Mary E.; Gagliardi, Christine; Foster, Aaron E.; Bayle, J. Henri

Year: 2020

Venue: Blood

DOI: https://doi.org/10.1182/blood-2020-140848

Paper A Phase I Study of FT819, a First-of-Kind, Off-the-Shelf, iPSC-Derived TCR-Less CD19 CAR T Cell Therapy for the Treatment of Relapsed/Refractory B-Cell Malignancies

Jae H. Park; N. Jain; A. Chen et al. · 2020 · DOI

Full title: A Phase I Study of FT819, a First-of-Kind, Off-the-Shelf, iPSC-Derived TCR-Less CD19 CAR T Cell Therapy for the Treatment of Relapsed/Refractory B-Cell Malignancies

Authors: Jae H. Park; N. Jain; A. Chen; J. Mcguirk; M. Díaz; Bahram Valamehr; Y. Chu; J. Castro

Year: 2020

DOI: https://doi.org/10.1182/blood-2020-142423

Paper Molecular and Phenotypic Profiling of Drug Product and Post-Infusion Samples from CRB-402, an Ongoing: Phase I Clinical Study of bb21217 a BCMA-Directed CAR T Cell Therapy

O. Finney; Ashish S. Yeri; Pingping Mao et al. · 2020 · DOI

Full title: Molecular and Phenotypic Profiling of Drug Product and Post-Infusion Samples from CRB-402, an Ongoing: Phase I Clinical Study of bb21217 a BCMA-Directed CAR T Cell Therapy

Authors: O. Finney; Ashish S. Yeri; Pingping Mao; Chetanya Pandya; E. Alonzo; Gregory Hopkins; S. Hymson; Tiffany Hu; Marianna Foos; S. Bhadoriya; S. Hintzen; Maple Gioia; A. Timm; M. Massaro; Ronald J. Hause; S. Kaiser; N. Martin; M. Alsina; N. Shah; N. Raje; J. Berdeja; S. Grande; H. Bitter; F. Petrocca; Kevin G. Friedman; D. Sangurdekar

Year: 2020

DOI: https://doi.org/10.1182/blood-2020-142426

Paper Preclinical Evaluation of ALLO-605, an Allogeneic BCMA Turbocar TTM Cell Therapy for the Treatment of Multiple Myeloma

C. Sommer; R. Lin; Janette Sutton et al. · 2020 · DOI

Full title: Preclinical Evaluation of ALLO-605, an Allogeneic BCMA Turbocar TTM Cell Therapy for the Treatment of Multiple Myeloma

Authors: C. Sommer; R. Lin; Janette Sutton; Trevor Bentley; D. Nguyen; Hayung Yoon; M. Au; D. Vargas-Inchaustegui; Hsin‐Yuan Cheng; Thomas Van Blarcom; S. Panowski; B. Sasu

Year: 2020

DOI: https://doi.org/10.1182/blood-2020-141477

Paper Optimizing Commercial Manufacturing of Tisagenlecleucel for Patients in the US: A 4-Year Experiential Journey

Margarida Rodrigues; Emmanuel Duran; Bernd Eschgfaeller et al. · 2021 · Blood · DOI

Full title: Optimizing Commercial Manufacturing of Tisagenlecleucel for Patients in the US: A 4-Year Experiential Journey

Authors: Margarida Rodrigues; Emmanuel Duran; Bernd Eschgfaeller; D. Kuzan; K. Habucky

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood-2021-144897

Paper FT576: Multi-Specific Off-the-Shelf CAR-NK Cell Therapy Engineered for Enhanced Persistence, Avoidance of Self-Fratricide and Optimized Mab Combination Therapy to Prevent Antigenic Escape and Elicit a Deep and Durable Response in Multiple Myeloma

Jode Goodridge; R. Bjordahl; S. Mahmood et al. · 2020 · DOI

Full title: FT576: Multi-Specific Off-the-Shelf CAR-NK Cell Therapy Engineered for Enhanced Persistence, Avoidance of Self-Fratricide and Optimized Mab Combination Therapy to Prevent Antigenic Escape and Elicit a Deep and Durable Response in Multiple Myeloma

Authors: Jode Goodridge; R. Bjordahl; S. Mahmood; John Reiser; S. Gaidarova; R. Blum; Frank Cichocki; Hui-yi Chu; G. Bonello; T. Lee; B. Groff; M. Meza; Y. Chu; B. Walcheck; Karl-Johan Malmberg; Jeffrey S. Miller; A. Rehm; U. Höpken; Bahram Valamehr

Year: 2020

DOI: https://doi.org/10.1182/blood-2020-142750

Paper PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity

Funk, Christopher Ronald; Wang, Shuhua; Chen, Kevin Z. et al. · 2022 · Blood · DOI

Full title: PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity

Authors: Funk, Christopher Ronald; Wang, Shuhua; Chen, Kevin Z.; Waller, Alexandra; Sharma, Aditi; Edgar, Claudia L.; Gupta, Vikas A.; Chandrakasan, Shanmuganathan; Zoine, Jaquelyn T.; Fedanov, Andrew; Raikar, Sunil S.; Koff, Jean L.; Flowers, Christopher R.; Coma, Sílvia; Pachter, Jonathan A.; Ravindranathan, Sruthi; Spencer, H. Trent; Shanmugam, Mala; Waller, Edmund K.

Year: 2022

Venue: Blood

DOI: https://doi.org/10.1182/blood.2021011597

Paper NOTCH1 signaling during CD4+ T-cell activation alters transcription factor networks and enhances antigen responsiveness.

Alec B. Wilkens; Elena Fulton; M. Pont et al. · 2022 · Blood · DOI

Full title: NOTCH1 signaling during CD4+ T-cell activation alters transcription factor networks and enhances antigen responsiveness.

Authors: Alec B. Wilkens; Elena Fulton; M. Pont; G. Cole; Isabel Leung; Sylvia M. Stull; Matthew R Hart; I. Bernstein; S. Furlan; S. Riddell

Year: 2022

Venue: Blood

DOI: https://doi.org/10.1182/blood.2021015144

Paper Phase I Study of PHE885, a Fully Human BCMA-Directed CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma Manufactured in <2 Days Using the T-Charge TM Platform

A. Sperling; S. Nikiforow; Omar Nadeem et al. · 2021 · Blood · DOI

Full title: Phase I Study of PHE885, a Fully Human BCMA-Directed CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma Manufactured in <2 Days Using the T-Charge TM Platform

Authors: A. Sperling; S. Nikiforow; Omar Nadeem; C. Mo; J. Laubach; K. Anderson; A. Alonso; Shuntaro Ikegawa; R. Prabhala; Diego Hernandez rodriguez; H. Daley; K. Shaw; Y. Arihara; Soudeh Ansari; D. Quinn; David Pearson; A. Hack; L. Treanor; D. Bu; J. Mataraza; L. Rispoli; M. Credi; J. Ritz; S. De Vita; N. Munshi

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood-2021-146646

Paper Iomab with Adoptive Cellular Therapy (Iomab-ACT): A Pilot Study of 131-I Apamistamab Followed By CD19-Targeted CAR T-Cell Therapy for Patients with Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia or Diffuse Large B-Cell Lymphoma

M. Geyer; Briana Cadzin; E. Halton et al. · 2021 · Blood · DOI

Full title: Iomab with Adoptive Cellular Therapy (Iomab-ACT): A Pilot Study of 131-I Apamistamab Followed By CD19-Targeted CAR T-Cell Therapy for Patients with Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia or Diffuse Large B-Cell Lymphoma

Authors: M. Geyer; Briana Cadzin; E. Halton; P. Kane; B. Senechal; Eileen M. Geoghegan; V. Reddy; M. Berger; D. Ludwig; N. Pandit-Taskar; C. Sauter

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood-2021-144994

Paper Bispecific LV20.19 CAR T-Cells Expanded in IL-7 and IL-15 Have Greater Polyfunctionality and Polyfunctional Strength Than CAR T-Cells Expanded in IL-2

J. Zurko; Huiqing Xu; K. Chaney et al. · 2021 · Blood · DOI

Full title: Bispecific LV20.19 CAR T-Cells Expanded in IL-7 and IL-15 Have Greater Polyfunctionality and Polyfunctional Strength Than CAR T-Cells Expanded in IL-2

Authors: J. Zurko; Huiqing Xu; K. Chaney; T. Fenske; M. Hamadani; D. Schneider; P. Hari; Bryon D. Johnson; N. Shah

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood-2021-146882

Paper A First-in-Human Study of YTB323, a Novel, Autologous CD19-Directed CAR-T Cell Therapy Manufactured Using the Novel T-Charge TM platform, for the Treatment of Patients (Pts) with Relapsed/Refractory (r/r) Diffuse Large B-Cell Lymphoma (DLBCL)

I. Flinn; U. Jaeger; N. Shah et al. · 2021 · Blood · DOI

Full title: A First-in-Human Study of YTB323, a Novel, Autologous CD19-Directed CAR-T Cell Therapy Manufactured Using the Novel T-Charge TM platform, for the Treatment of Patients (Pts) with Relapsed/Refractory (r/r) Diffuse Large B-Cell Lymphoma (DLBCL)

Authors: I. Flinn; U. Jaeger; N. Shah; D. Blaise; J. Briones; L. Shune; N. Boissel; A. Bondanza; Darlene Lu; Xu Zhu; B. Engels; J. Brogdon; J. Mataraza; Jaclyn Davis; A. Marchal; L. Mariconti; M. Moschetta; L. M. Parseval; P. Barba; M. Dickinson

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood-2021-146268

Paper Phase 1/2 Trial of IL7/IL15-Expanded Bispecific LV20.19 CAR T-Cells for Relapsed, Refractory B-Cell Non-Hodgkin Lymphoma

N. Shah; J. Zurko; D. Schneider et al. · 2021 · Blood · DOI

Full title: Phase 1/2 Trial of IL7/IL15-Expanded Bispecific LV20.19 CAR T-Cells for Relapsed, Refractory B-Cell Non-Hodgkin Lymphoma

Authors: N. Shah; J. Zurko; D. Schneider; Sharon Yim; M. Hamadani; T. Fenske; Bryon D. Johnson; P. Hari

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood-2021-146638

Paper Manufacturing Bispecific LV20.19 CAR T-Cells with IL-7 & IL-15 for a Shorter Duration Improves CAR T-Cell Immunophenotype While Maintaining Target Cell Dose

J. Zurko; K. Chaney; Huiqing Xu et al. · 2021 · Blood · DOI

Full title: Manufacturing Bispecific LV20.19 CAR T-Cells with IL-7 & IL-15 for a Shorter Duration Improves CAR T-Cell Immunophenotype While Maintaining Target Cell Dose

Authors: J. Zurko; K. Chaney; Huiqing Xu; D. Schneider; P. Hari; Bryon D. Johnson; N. Shah

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood-2021-147405

Paper SCRI-CAR19x22v2 T Cell Product Demonstrates Bispecific Activity in B-ALL

Colleen Annesley; C. Summers; M. Pulsipher et al. · 2021 · Blood · DOI

Full title: SCRI-CAR19x22v2 T Cell Product Demonstrates Bispecific Activity in B-ALL

Authors: Colleen Annesley; C. Summers; M. Pulsipher; J. Skiles; Amanda M Li; A. Vatsayan; C. Lindgren; Stephanie Mgebroff; A. Wilson; Wenjun Huang; Q. Wu; Josh Gustafson; Christopher Brown; M. Jensen; Julie R. Park; R. Gardner

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood-2021-148881

Paper Tc Buster Transposon Engineered CLL-1 CAR-NK Cells Efficiently Target Acute Myeloid Leukemia

M. Gurney; Eimear O'Reilly; Sarah E. Corcoran et al. · 2021 · Blood · DOI

Full title: Tc Buster Transposon Engineered CLL-1 CAR-NK Cells Efficiently Target Acute Myeloid Leukemia

Authors: M. Gurney; Eimear O'Reilly; Sarah E. Corcoran; Sarah Brophy; D. Hardwicke; J. Krawczyk; D. Hermanson; R. Childs; E. Szegezdi; M. O'Dwyer

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood-2021-147244

Paper Induced Pluripotent Stem Cell-Derived Gamma Delta CAR-T Cells for Cancer Immunotherapy

Mark A. Wallet; T. Nishimura; C. Del Casale et al. · 2021 · Blood · DOI

Full title: Induced Pluripotent Stem Cell-Derived Gamma Delta CAR-T Cells for Cancer Immunotherapy

Authors: Mark A. Wallet; T. Nishimura; C. Del Casale; Andriana Lebid; Brenda Salantes; Katherine E. Santostefano; Sydney Bucher; M. Mendonca; M. Beqiri; L. Thompson; B. Morse; Hillary Millar Quinn; Luis Borges

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood-2021-149095

Paper Preclinical Evaluation of Prgn-3007, a Non-Viral, Multigenic, Autologous ROR1 Ultracar-T ® Therapy with Novel Mechanism of Intrinsic PD-1 Blockade for Treatment of Hematological and Solid Cancers

T. Chan; S. Scott; Mengyan Du et al. · 2021 · Blood · DOI

Full title: Preclinical Evaluation of Prgn-3007, a Non-Viral, Multigenic, Autologous ROR1 Ultracar-T ® Therapy with Novel Mechanism of Intrinsic PD-1 Blockade for Treatment of Hematological and Solid Cancers

Authors: T. Chan; S. Scott; Mengyan Du; Cheryl Bolinger; C. Poortman; Lindsey Shepard; Byron Koenitzer; Adeline Govekung; Carlos Sailor; Rahim Johnson; Jacques Plummer; Steven Zilko; Shourik Dutta; Kannan Kunchithapautham; Taranjit Athwal; B. Klocke; C. Zinser; Maha Abdeladhim; Shamim Ahmad; Simon Metenou; R. Semnani; D. Brough; Rutul R. Shah; H. Sabzevari

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood-2021-149203

Paper Final Results of a Phase 1 Study of AntiCD19 CAR-T Cells with TNFRSF19 Transmembrane Domain

P. Caimi; A. Ghobadi; J. Reese et al. · 2021 · Blood · DOI

Full title: Final Results of a Phase 1 Study of AntiCD19 CAR-T Cells with TNFRSF19 Transmembrane Domain

Authors: P. Caimi; A. Ghobadi; J. Reese; B. Tomlinson; F. Otegbeye; Julie Ritchey; Tabatha Trummer; J. Schiavone; K. Zamborsky; L. Eissenberg; Julia Hollaway; D. Schneider; Kristen Bakalarz; K. Boughan; L. Metheny; S. Patel; E. Galloway; M. Gallogly; W. Krueger; M. Kadan; Gabriela Pacheco Sanchez; A. Sharma; D. Wald; B. Cooper; J. Dipersio; R. Sékaly; R. Orentas; B. Dropulić; M. de Lima

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood-2021-151155

Paper Preliminary Results from the Flu/Cy/Alemtuzumab Arm of the Phase I BALLI-01 Trial of UCART22, an Anti-CD22 Allogeneic CAR-T Cell Product, in Adult Patients with Relapsed or Refractory (R/R) CD22+ B-Cell Acute Lymphoblastic Leukemia (B-ALL)

N. Jain; G. Roboz; M. Konopleva et al. · 2021 · Blood · DOI

Full title: Preliminary Results from the Flu/Cy/Alemtuzumab Arm of the Phase I BALLI-01 Trial of UCART22, an Anti-CD22 Allogeneic CAR-T Cell Product, in Adult Patients with Relapsed or Refractory (R/R) CD22+ B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Authors: N. Jain; G. Roboz; M. Konopleva; Hongtao Liu; G. Schiller; E. Jabbour; D. Whitfield; Asifa Haider; O. Zernovak; M. Frattini; C. Brownstein; R. Larson

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood-2021-150779

Paper Duvelisib Promotes Mitochondrial Fusion and Epigenetic Reprogramming to Drive Therapeutic T Cell Persistence and Function

Kevin Z Chen; C. R. Funk; Shuhua Wang et al. · 2021 · Blood · DOI

Full title: Duvelisib Promotes Mitochondrial Fusion and Epigenetic Reprogramming to Drive Therapeutic T Cell Persistence and Function

Authors: Kevin Z Chen; C. R. Funk; Shuhua Wang; Aditi Sharma; E. Waller; M. Shanmugam

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood-2021-153446

Paper CD19/22 CAR T cells in children and young adults with B-ALL: phase 1 results and development of a novel bicistronic CAR.

Shalabi, Haneen; Qin, Haiying; Su, Angela et al. · 2022 · Blood · DOI

Full title: CD19/22 CAR T cells in children and young adults with B-ALL: phase 1 results and development of a novel bicistronic CAR.

Authors: Shalabi, Haneen; Qin, Haiying; Su, Angela; Yates, Bonnie; Wolters, Pamela L; Steinberg, Seth M; Ligon, John A; Silbert, Sara; DéDé, Kniya; Benzaoui, Mehdi; Goldberg, Sophia; Achar, Sooraj; Schneider, Dina; Shahani, Shilpa A; Little, Lauren; Foley, Toni; Molina, John C; Panch, Sandhya; Mackall, Crystal L; Lee, Daniel W; Chien, Christopher D; Pouzolles, Marie; Ahlman, Mark; Yuan, Constance M; Wang, Hao-Wei; Wang, Yanyu; Inglefield, Jon; Toledo-Tamula, Mary Anne; Martin, Staci; Highfill, Steven L; Altan-Bonnet, Gregoire; Stroncek, David; Fry, Terry J; Taylor, Naomi; Shah, Nirali N

Year: 2022

Venue: Blood

DOI: https://doi.org/10.1182/blood.2022015795

Paper Clinical Translation of SC-DARIC33: A Pharmacologically Controlled CD33-Targeted Anti-AML CAR T Cell Product Regulated By Low Nanomolar Concentrations of Rapamycin

Jacob S Appelbaum; April E. Price; Joy Zhang et al. · 2021 · Blood · DOI

Full title: Clinical Translation of SC-DARIC33: A Pharmacologically Controlled CD33-Targeted Anti-AML CAR T Cell Product Regulated By Low Nanomolar Concentrations of Rapamycin

Authors: Jacob S Appelbaum; April E. Price; Joy Zhang; K. Oda; S. Sundaram; Paula Lewis; S. Bilic; G. Tampella; D. Xia; Anne-Rachel F. Krostag; P. So; U. Martin; W. Leung; A. Astrakhan; M. Pogson; Jordan Jarjour; Josh Gustafson; M. Jensen

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood-2021-154461

Paper Early Signals of Anti-Tumor Efficacy and Safety with Autologous CD5.CAR T-Cells in Patients with Refractory/Relapsed T-Cell Lymphoma

R. Rouce; LaQuisa C. Hill; Tyler S. Smith et al. · 2021 · Blood · DOI

Full title: Early Signals of Anti-Tumor Efficacy and Safety with Autologous CD5.CAR T-Cells in Patients with Refractory/Relapsed T-Cell Lymphoma

Authors: R. Rouce; LaQuisa C. Hill; Tyler S. Smith; Lina Yang; Blakely Boriskie; Madhuwanti Srinivasan; Huimin Zhang; S. Perconti; B. Mehta; O. Dakhova; B. Grilley; H. Heslop; M. Brenner; Maksim Mamonkin

Year: 2021

Venue: Blood

DOI: https://doi.org/10.1182/blood-2021-154142

Paper Nanoporous Substrates to Advance CAR-T Cell Production for Advanced Cell Therapies

Tamara Zünd; S. Lickert; A. Strebel et al. · 2023 · Blood · DOI

Full title: Nanoporous Substrates to Advance CAR-T Cell Production for Advanced Cell Therapies

Authors: Tamara Zünd; S. Lickert; A. Strebel; Marcia Murner; Tido Willms; Hasan Simsek; Weijie Du; D. Wagner; V. Vogel; Enrico Klotzsch

Year: 2023

Venue: Blood

DOI: https://doi.org/10.1182/blood-2023-179155

Paper Effective Cell Dose and Functional Attributes of Azercabtagene Zapreleucel (azer-cel; PBCAR0191) Associate with Allogeneic CAR T-Cell Safety and Efficacy in Patients with Relapsed/Refractory B-Cell Lymphoma

Jacobson, Caron A.; Jayawardena, Tilanthi M.; Yu, Lou et al. · 2022 · Blood · DOI

Full title: Effective Cell Dose and Functional Attributes of Azercabtagene Zapreleucel (azer-cel; PBCAR0191) Associate with Allogeneic CAR T-Cell Safety and Efficacy in Patients with Relapsed/Refractory B-Cell Lymphoma

Authors: Jacobson, Caron A.; Jayawardena, Tilanthi M.; Yu, Lou; Hallman, Jason J.; Schmittling, Robert J.; Cuneo, Erin; Belle, Ian; Sampey, Gavin C.; Cabral, Danica; Derrick, Ashleigh; Tueller, Josie A.; Besien, Koen van; Solomon, Scott R.; Olszewski, Adam J.; Maakaron, Joseph; Reshef, Ran; Stein, Anthony S.; Deol, Abhinav; Jain, Nitin; List, Alan F.; Shah, Bijal

Year: 2022

Venue: Blood

DOI: https://doi.org/10.1182/blood-2022-165311

Paper API-192, an Allogeneic CD19/20 CAR-NKT Cell Product Derived from Cord Blood CD34+ HSPCs for the Treatment of B-Cell Malignancies

Lanny Gov; Jiaji Yu; Maha Qubain et al. · 2023 · Blood · DOI

Full title: API-192, an Allogeneic CD19/20 CAR-NKT Cell Product Derived from Cord Blood CD34+ HSPCs for the Treatment of B-Cell Malignancies

Authors: Lanny Gov; Jiaji Yu; Maha Qubain; Saige L. Pompura; Sean D. Allen; Michael A. Christopher; Jeff Wiezorek

Year: 2023

Venue: Blood

DOI: https://doi.org/10.1182/blood-2023-181271

Paper Phase I First-in-Human Study on the Feasibility, Safety, and Antitumor Activity of CD4-Redirected Chimeric Antigen Receptor (CAR) T-Cell Therapy in Patients with CD4+ T-Cell Malignancies (TCM)

Rita Assi; Nabil Hagag; Sherif S Farag et al. · 2023 · Blood · DOI

Full title: Phase I First-in-Human Study on the Feasibility, Safety, and Antitumor Activity of CD4-Redirected Chimeric Antigen Receptor (CAR) T-Cell Therapy in Patients with CD4+ T-Cell Malignancies (TCM)

Authors: Rita Assi; Nabil Hagag; Sherif S Farag; R. Emmons; Allie Carter; Magdalena Czader; R. Abonour; Lionel Apetoh; Yupo Ma; H. Salman

Year: 2023

Venue: Blood

DOI: https://doi.org/10.1182/blood-2023-180111

Paper Biomarker Correlates of Response to Ciltacabtagene Autoleucel in Patients with Relapsed or Refractory Multiple Myeloma from CARTITUDE-1, a Phase 1b/2 Open-Label Study, at the ~3 Year Follow-up

Rocio Montes de Oca; Junchen Gu; Hao Zhao et al. · 2023 · Blood · DOI

Full title: Biomarker Correlates of Response to Ciltacabtagene Autoleucel in Patients with Relapsed or Refractory Multiple Myeloma from CARTITUDE-1, a Phase 1b/2 Open-Label Study, at the ~3 Year Follow-up

Authors: Rocio Montes de Oca; Junchen Gu; Hao Zhao; Kathy Zelinsky; Dianna Wu; Cuc Davis; Jaymala Patel; Brad Foulk; R. Boominathan; Onsay Lau; Denis Smirnov; Yi Lin; Sundar Jagannath; A. Cohen; N. Haddish-Berhane; Jean Xu; D. Madduri; An-Sofie Stevens; Carolyn C. Jackson; J. Schecter; A. Banerjee; Dong Geng; Jieqing Zhu; Sifan Xu; E. Zudaire

Year: 2023

Venue: Blood

DOI: https://doi.org/10.1182/blood-2023-182298

Paper Manufacturing, Characterization and Anti-Tumor Activity of Allogeneic CD19-CAR Cytokine-Induced Killer (CIK) Cells Engineered with Non-Viral Sleeping Beauty Transposon System and Armored with IL-18

Laura Contreras-Ruiz; Barcley Pace; Dora E Kohnke et al. · 2023 · Blood · DOI

Full title: Manufacturing, Characterization and Anti-Tumor Activity of Allogeneic CD19-CAR Cytokine-Induced Killer (CIK) Cells Engineered with Non-Viral Sleeping Beauty Transposon System and Armored with IL-18

Authors: Laura Contreras-Ruiz; Barcley Pace; Dora E Kohnke; Lindsey Viruet; Melissa Adams; John F Krisko; Noah Leesnitzer; Marissa Velie; Sarah Tettamanti; Ilaria Pisani; Giusi Melita; Andrea Biondi; A. Rambaldi; I. Tcherepanova; R. Brentjens; C. Nicolette

Year: 2023

Venue: Blood

DOI: https://doi.org/10.1182/blood-2023-181005

Paper CAR-T cell expansion platforms yield distinct T cell differentiation states.

Song, Hannah W; Prochazkova, Michaela; Shao, Lipei et al. · 2024 · Cytotherapy · DOI

Full title: CAR-T cell expansion platforms yield distinct T cell differentiation states.

Authors: Song, Hannah W; Prochazkova, Michaela; Shao, Lipei; Traynor, Roshini; Underwood, Sarah; Black, Mary; Fellowes, Vicki; Shi, Rongye; Pouzolles, Marie; Chou, Hsien-Chao; Cheuk, Adam T; Taylor, Naomi; Jin, Ping; Somerville, Robert P; Stroncek, David F; Khan, Javed; Highfill, Steven L

Year: 2024

Venue: Cytotherapy

DOI: https://doi.org/10.1016/j.jcyt.2024.03.003

Paper Lymph-Node Inspired Hydrogels Enhance CAR Expression and Proliferation of CAR T Cells

Miquel Castellote-Borrell; Marc Domingo; Francesca Merlina et al. · 2025 · ACS Applied Materials and Interfaces · DOI

Full title: Lymph-Node Inspired Hydrogels Enhance CAR Expression and Proliferation of CAR T Cells

Authors: Miquel Castellote-Borrell; Marc Domingo; Francesca Merlina; Huixia Lu; Salut Colell; M. Bachiller; Manel Juan; Sònia Guedan; Jordi Faraudo; Judith Guasch

Year: 2025

Venue: ACS Applied Materials and Interfaces

DOI: https://doi.org/10.1021/acsami.4c19942

Paper Chimeric antigen receptor (CAR)-transduced natural killer cells in tumor immunotherapy

Hu, Yuan; Tian, Zhigang; Zhang, Cai · 2017 · Acta Pharmacologica Sinica · DOI

Full title: Chimeric antigen receptor (CAR)-transduced natural killer cells in tumor immunotherapy

Authors: Hu, Yuan; Tian, Zhigang; Zhang, Cai

Year: 2017

Venue: Acta Pharmacologica Sinica

DOI: https://doi.org/10.1038/aps.2017.125

Paper Clinical application of genetically modified T cells in cancer therapy

Kershaw, Michael H.; Westwood, Jennifer A.; Slaney, Clare Y. et al. · 2014 · Clinical & Translational Immunology · DOI

Full title: Clinical application of genetically modified T cells in cancer therapy

Authors: Kershaw, Michael H.; Westwood, Jennifer A.; Slaney, Clare Y.; Darcy, Phillip K.

Year: 2014

Venue: Clinical & Translational Immunology

DOI: https://doi.org/10.1038/cti.2014.7

Paper CAR T‐cell therapy of solid tumors

Yong, Carmen S.; Dardalhon, Valérie; Devaud, Christel et al. · 2016 · Immunology and Cell Biology · DOI

Full title: CAR T‐cell therapy of solid tumors

Authors: Yong, Carmen S.; Dardalhon, Valérie; Devaud, Christel; Taylor, Naomi; Darcy, Phillip K.; Kershaw, Michael H.

Year: 2016

Venue: Immunology and Cell Biology

DOI: https://doi.org/10.1038/icb.2016.128

Paper Biomaterials in Chimeric Antigen Receptor T-Cell Process Development.

Ian I. Cardle; Emmeline L. Cheng; M. Jensen et al. · 2020 · Accounts of Chemical Research · DOI

Full title: Biomaterials in Chimeric Antigen Receptor T-Cell Process Development.

Authors: Ian I. Cardle; Emmeline L. Cheng; M. Jensen; S. Pun

Year: 2020

Venue: Accounts of Chemical Research

DOI: https://doi.org/10.1021/acs.accounts.0c00335

Paper Decentralized manufacturing of anti CD19 CAR-T cells using CliniMACS Prodigy®: real-world experience and cost analysis in India

Hamenth Kumar Palani; A. Arunachalam; M. Yasar et al. · 2022 · Bone Marrow Transplantation · DOI

Full title: Decentralized manufacturing of anti CD19 CAR-T cells using CliniMACS Prodigy®: real-world experience and cost analysis in India

Authors: Hamenth Kumar Palani; A. Arunachalam; M. Yasar; Arvind Venkatraman; U. Kulkarni; S. Lionel; S. Selvarajan; A. Korula; A. Abraham; B. George; J. Adair; R. Orentas; B. Dropulić; V. Mathews

Year: 2022

Venue: Bone Marrow Transplantation

DOI: https://doi.org/10.1038/s41409-022-01866-5

Paper Natural killer cells in antitumour adoptive cell immunotherapy

Laskowski, Tamara; Biederstädt, Alexander; Rezvani, Katayoun · 2022 · Nature reviews. Cancer · DOI

Full title: Natural killer cells in antitumour adoptive cell immunotherapy

Authors: Laskowski, Tamara; Biederstädt, Alexander; Rezvani, Katayoun

Year: 2022

Venue: Nature reviews. Cancer

DOI: https://doi.org/10.1038/s41568-022-00491-0

Paper Engineering strategies to overcome the current roadblocks in CAR T cell therapy

Rafiq, Sarwish; Hackett, Christopher S.; Brentjens, Renier J. · 2019 · Nature Reviews Clinical Oncology · DOI

Full title: Engineering strategies to overcome the current roadblocks in CAR T cell therapy

Authors: Rafiq, Sarwish; Hackett, Christopher S.; Brentjens, Renier J.

Year: 2019

Venue: Nature Reviews Clinical Oncology

DOI: https://doi.org/10.1038/s41571-019-0297-y

Paper Rapid manufacturing of non-activated potent CAR T cells

S. Ghassemi; Joseph S. Durgin; S. Nunez-Cruz et al. · 2022 · Nature Biomedical Engineering · DOI

Full title: Rapid manufacturing of non-activated potent CAR T cells

Authors: S. Ghassemi; Joseph S. Durgin; S. Nunez-Cruz; Jai Patel; J. Leferovich; M. Pinzone; Feng Shen; K. Cummins; G. Plesa; V. A. Cantu; Shantan Reddy; F. Bushman; S. Gill; U. O’Doherty; Roddy S. O’Connor; M. Milone

Year: 2022

Venue: Nature Biomedical Engineering

DOI: https://doi.org/10.1038/s41551-021-00842-6

Paper Engineering the next generation of cell-based therapeutics

Bashor, Caleb J.; Hilton, Isaac B.; Bandukwala, Hozefa S. et al. · 2022 · Nature Reviews Drug Discovery · DOI

Full title: Engineering the next generation of cell-based therapeutics

Authors: Bashor, Caleb J.; Hilton, Isaac B.; Bandukwala, Hozefa S.; Smith, Devyn M.; Veiseh, Omid

Year: 2022

Venue: Nature Reviews Drug Discovery

DOI: https://doi.org/10.1038/s41573-022-00476-6

Paper Expanding access to CAR T cell therapies through local manufacturing

Magdi Elsallab; M. Maus · 2023 · Nature Biotechnology · DOI

Full title: Expanding access to CAR T cell therapies through local manufacturing

Authors: Magdi Elsallab; M. Maus

Year: 2023

Venue: Nature Biotechnology

DOI: https://doi.org/10.1038/s41587-023-01981-8

Paper Development of a microfluidic cell transfection device into gene-edited CAR T cell manufacturing workflow.

Tong Yu; Navdeep Jhita; Peter Shankles et al. · 2023 · Lab on a Chip · DOI

Full title: Development of a microfluidic cell transfection device into gene-edited CAR T cell manufacturing workflow.

Authors: Tong Yu; Navdeep Jhita; Peter Shankles; Andrew Fedanov; Noah B. Kramer; Sunil S. Raikar; Todd Sulchek

Year: 2023

Venue: Lab on a Chip

DOI: https://doi.org/10.1039/d3lc00311f

Paper Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory

Viaud, Sophie; Jennifer, S. Y.; Hardy, Ian R. et al. · 2018 · Proceedings of the National Academy of Sciences · DOI

Full title: Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory

Authors: Viaud, Sophie; Jennifer, S. Y.; Hardy, Ian R.; Hampton, Eric; Benish, Brent; Sherwood, Lance; Núñez, Vanessa; Ackerman, Christopher J.; Khialeeva, Elvira; Weglarz, Meredith; Lee, Sung Chang; Woods, Ashley K.; Young, Travis S.

Year: 2018

Venue: Proceedings of the National Academy of Sciences

DOI: https://doi.org/10.1073/pnas.1810060115

Paper Enhanced CAR T-Cell Therapy for Lymphoma after Previous Failure.

Svoboda, Jakub; Landsburg, Daniel J; Gerson, James et al. · 2025 · The New England journal of medicine · DOI

Full title: Enhanced CAR T-Cell Therapy for Lymphoma after Previous Failure.

Authors: Svoboda, Jakub; Landsburg, Daniel J; Gerson, James; Nasta, Sunita D; Barta, Stefan K; Chong, Elise A; Cook, Michael; Frey, Noelle V; Shea, Joanne; Cervini, Amanda; Marshall, Amy; Four, Megan; Davis, Megan M; Jadlowsky, Julie K; Chew, Anne; Pequignot, Edward; Gonzalez, Vanessa; Noll, Julia Han; Paruzzo, Luca; Rojas-Levine, Juliana; Plesa, Gabriela; Scholler, John; Siegel, Donald L; Levine, Bruce L; Porter, David L; Ghassemi, Saba; Ruella, Marco; Rech, Andrew; Leskowitz, Rachel M; Fraietta, Joseph A; Hwang, Wei-Ting; Hexner, Elizabeth; Schuster, Stephen J; June, Carl H

Year: 2025

Venue: The New England journal of medicine

DOI: https://doi.org/10.1056/NEJMoa2408771

Paper Scaling up and scaling out: Advances and challenges in manufacturing engineered T cell therapies

Hannah W Song; R. Somerville; D. Stroncek et al. · 2022 · International Reviews of Immunology · DOI

Full title: Scaling up and scaling out: Advances and challenges in manufacturing engineered T cell therapies

Authors: Hannah W Song; R. Somerville; D. Stroncek; S. Highfill

Year: 2022

Venue: International Reviews of Immunology

DOI: https://doi.org/10.1080/08830185.2022.2067154

Paper Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

Neelapu, Sattva S.; Locke, Frederick L.; Bartlett, Nancy L. et al. · 2017 · New England Journal of Medicine · DOI

Full title: Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

Authors: Neelapu, Sattva S.; Locke, Frederick L.; Bartlett, Nancy L.; Lekakis, Lazaros J.; Miklos, David B.; Jacobson, Caron A.; Braunschweig, Ira; Oluwole, Olalekan O.; Siddiqi, Tanya; Lin, Yi; Timmerman, John M.; Stiff, Patrick J.; Friedberg, Jonathan W.; Flinn, Ian W.; Goy, André; Hill, Brian T.; Smith, Mitchell R.; Deol, Abhinav; Farooq, Umar; McSweeney, Peter A.; Muñoz, Javier; Avivi, Irit; Castro, Januario E.; Westin, Jason R.; Chávez, Julio C.; Ghobadi, Armin; Komanduri, Krishna V.; Levy, Ronald; Jacobsen, Eric D.; Witzig, Thomas E.; Reagan, Patrick M.; Bot, Adrian; Rossi, John M.; Navale, Lynn; Jiang, Yizhou; Aycock, Jeff; Elias, Meg; Chang, David; Wiezorek, Jeff; Go, William Y.

Year: 2017

Venue: New England Journal of Medicine

DOI: https://doi.org/10.1056/nejmoa1707447

Paper Establishing a model system for evaluating CAR T cell therapy using dogs with spontaneous diffuse large B cell lymphoma

M. K. Panjwani; M. Atherton; Martha A MaloneyHuss et al. · 2019 · Oncoimmunology · DOI

Full title: Establishing a model system for evaluating CAR T cell therapy using dogs with spontaneous diffuse large B cell lymphoma

Authors: M. K. Panjwani; M. Atherton; Martha A MaloneyHuss; K. P. Haran; Ailian Xiong; Minnal Gupta; Irina Kulikovsaya; S. Lacey; Nicola J. Mason

Year: 2019

Venue: Oncoimmunology

DOI: https://doi.org/10.1080/2162402x.2019.1676615

Paper Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies

Rodgers, David T.; Mazagova, Magdalena; Hampton, Eric et al. · 2016 · Proceedings of the National Academy of Sciences · DOI

Full title: Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies

Authors: Rodgers, David T.; Mazagova, Magdalena; Hampton, Eric; Cao, Yu; Ramadoss, Nitya S.; Hardy, Ian R.; Schulman, Andrew D.; Du, Juanjuan; Wang, Feng; Singer, Oded; Ma, Jennifer; Núñez, Vanessa; Shen, Jiayin; Woods, Ashley K.; Wright, Timothy M.; Schultz, Peter G.; Kim, Chan Hyuk; Young, Travis S.

Year: 2016

Venue: Proceedings of the National Academy of Sciences

DOI: https://doi.org/10.1073/pnas.1524155113

Paper IL-21-reprogrammed Vδ1 T cells exert killing against solid tumors which is enhanced by CAR arming for off-the-shelf immunotherapy

Ana L. Portillo; Misaal Mehboob; Genesis Snyder et al. · 2025 · Oncoimmunology · DOI

Full title: IL-21-reprogrammed Vδ1 T cells exert killing against solid tumors which is enhanced by CAR arming for off-the-shelf immunotherapy

Authors: Ana L. Portillo; Misaal Mehboob; Genesis Snyder; Adnan Moinuddin; Tyrah M. Ritchie; Elizabeth Balint; Allyson E. Moore; Mohammadamin Sookhaklari; Jonathan L. Bramson; Dean A Lee; Meisam Naeimi Kararoudi; A. Ashkar

Year: 2025

Venue: Oncoimmunology

DOI: https://doi.org/10.1080/2162402x.2025.2562210

Paper Nutrients: Signal 4 in T cell immunity

Raynor, Jana; Chi, Hongbo · 2024 · The Journal of Experimental Medicine · DOI

Full title: Nutrients: Signal 4 in T cell immunity

Authors: Raynor, Jana; Chi, Hongbo

Year: 2024

Venue: The Journal of Experimental Medicine

DOI: https://doi.org/10.1084/jem.20221839

Paper Spheroid Coculture of Hematopoietic Stem/Progenitor Cells and Monolayer Expanded Mesenchymal Stem/Stromal Cells in Polydimethylsiloxane Microwells Modestly Improves In Vitro Hematopoietic Stem/Progenitor Cell Expansion

Kathryn Futrega; Kerry Atkinson; W. B. Lott et al. · 2017 · Tissue Engineering. Part C, Methods · DOI

Full title: Spheroid Coculture of Hematopoietic Stem/Progenitor Cells and Monolayer Expanded Mesenchymal Stem/Stromal Cells in Polydimethylsiloxane Microwells Modestly Improves In Vitro Hematopoietic Stem/Progenitor Cell Expansion

Authors: Kathryn Futrega; Kerry Atkinson; W. B. Lott; M. Doran

Year: 2017

Venue: Tissue Engineering. Part C, Methods

DOI: https://doi.org/10.1089/ten.tec.2016.0329

Paper Development of Automated Separation, Expansion, and Quality Control Protocols for Clinical-Scale Manufacturing of Primary Human NK Cells and Alpharetroviral Chimeric Antigen Receptor Engineering

Oberschmidt, Olaf; Morgan, Michael; Huppert, Volker et al. · 2019 · Human Gene Therapy Methods · DOI

Full title: Development of Automated Separation, Expansion, and Quality Control Protocols for Clinical-Scale Manufacturing of Primary Human NK Cells and Alpharetroviral Chimeric Antigen Receptor Engineering

Authors: Oberschmidt, Olaf; Morgan, Michael; Huppert, Volker; Kessler, Joerg; Gardlowski, Tanja; Matthies, Nadine; Aleksandrova, Krasimira; Arseniev, Lubomir; Schambach, Axel; Koehl, Ulrike; Kloeß, Stephan

Year: 2019

Venue: Human Gene Therapy Methods

DOI: https://doi.org/10.1089/hgtb.2019.039

Paper Exploring synthetic immunity: From boutique to global

B. Levine · 2017 · Human Vaccines & Immunotherapeutics · DOI

Full title: Exploring synthetic immunity: From boutique to global

Authors: B. Levine

Year: 2017

Venue: Human Vaccines & Immunotherapeutics

DOI: https://doi.org/10.1080/21645515.2017.1379842

Paper Automated Manufacturing of Potent CD20-Directed Chimeric Antigen Receptor T Cells for Clinical Use

Lock, Dominik; Mockel-Tenbrinck, Nadine; Drechsel, Katharina et al. · 2017 · Human Gene Therapy · DOI

Full title: Automated Manufacturing of Potent CD20-Directed Chimeric Antigen Receptor T Cells for Clinical Use

Authors: Lock, Dominik; Mockel-Tenbrinck, Nadine; Drechsel, Katharina; Barth, Carola; Mauer, Daniela; Schaser, Thomas; Kolbe, Carolin; Rawashdeh, Wa’el Al; Brauner, Janina; Hardt, Olaf; Pflug, Natali; Holtick, Udo; Borchmann, Peter; Assenmacher, Mario; Kaiser, Andrew

Year: 2017

Venue: Human Gene Therapy

DOI: https://doi.org/10.1089/hum.2017.111

Paper Cytokines in the Treatment of Cancer

Conlon, Kevin C.; Miljković, Miloš D.; Waldmann, Thomas A. · 2018 · Journal of Interferon & Cytokine Research · DOI

Full title: Cytokines in the Treatment of Cancer

Authors: Conlon, Kevin C.; Miljković, Miloš D.; Waldmann, Thomas A.

Year: 2018

Venue: Journal of Interferon & Cytokine Research

DOI: https://doi.org/10.1089/jir.2018.0019

Paper High CD62L expression predicts the generation of chimeric antigen receptor T cells with potent effector functions.

Kasuya, Hitomi; Zhang, Haosong; Ito, Yusuke et al. · 2024 · International immunology · DOI

Full title: High CD62L expression predicts the generation of chimeric antigen receptor T cells with potent effector functions.

Authors: Kasuya, Hitomi; Zhang, Haosong; Ito, Yusuke; Yoshikawa, Toshiaki; Nakashima, Takahiro; Li, Yang; Matsukawa, Tetsuya; Inoue, Satoshi; Kagoya, Yuki

Year: 2024

Venue: International immunology

DOI: https://doi.org/10.1093/intimm/dxae015

Paper Optimization of Human NK Cell Manufacturing: Fully Automated Separation, Improved Ex Vivo Expansion Using IL-21 with Autologous Feeder Cells, and Generation of Anti-CD123-CAR-Expressing Effector Cells

S. Klöss; O. Oberschmidt; Michael A. Morgan et al. · 2017 · Human Gene Therapy · DOI

Full title: Optimization of Human NK Cell Manufacturing: Fully Automated Separation, Improved Ex Vivo Expansion Using IL-21 with Autologous Feeder Cells, and Generation of Anti-CD123-CAR-Expressing Effector Cells

Authors: S. Klöss; O. Oberschmidt; Michael A. Morgan; Julia Dahlke; L. Arseniev; V. Huppert; Markus Granzin; Tanja Gardlowski; Nadine Matthies; S. Soltenborn; A. Schambach; U. Koehl

Year: 2017

Venue: Human Gene Therapy

DOI: https://doi.org/10.1089/hum.2017.157

Paper - **DOI:** 10.1093/jas/skab235.680 - **Authors:** S. H. White-Springer - **Year:** 2021 - **Journal:** Journal of Animal Science

S. H. White-Springer · 2021 · Journal of Animal Science · DOI

Full title: - **DOI:** 10.1093/jas/skab235.680 - **Authors:** S. H. White-Springer - **Year:** 2021 - **Journal:** Journal of Animal Science

Authors: S. H. White-Springer

Year: 2021

Venue: Journal of Animal Science

DOI: https://doi.org/10.1093/jas/skab235.680

Paper EXTH-56. Optimizing CAR T cell therapy for pediatric glioma: Enhancing persistence and efficacy with DNA methylation inhibition during manufacturing

Elton Vannoy; Zhongzhen Yi; Lynne El Ghorayeb et al. · 2025 · Neuro-Oncology · DOI

Full title: EXTH-56. Optimizing CAR T cell therapy for pediatric glioma: Enhancing persistence and efficacy with DNA methylation inhibition during manufacturing

Authors: Elton Vannoy; Zhongzhen Yi; Lynne El Ghorayeb; Kaleem L. Coleman; Katherine B. Chiappinelli; Dalia Haydar

Year: 2025

Venue: Neuro-Oncology

DOI: https://doi.org/10.1093/neuonc/noaf201.1389

Paper Predictive modeling of T-cell expansion: leveraging morphological metrics with invitrogen attune cytpix flow cytometer for enhanced cell therapy manufacturing 4539

Nicole Madfis; J. Padilla; Lina Zheng · 2025 · Journal of Immunology · DOI

Full title: Predictive modeling of T-cell expansion: leveraging morphological metrics with invitrogen attune cytpix flow cytometer for enhanced cell therapy manufacturing 4539

Authors: Nicole Madfis; J. Padilla; Lina Zheng

Year: 2025

Venue: Journal of Immunology

DOI: https://doi.org/10.1093/jimmun/vkaf283.2210

Paper SAXS‐enabled Macromolecular Engineering at SIBYLS

C. D. Hodge; Greg L. Hura · 2020 · The FASEB Journal · DOI

Full title: SAXS‐enabled Macromolecular Engineering at SIBYLS

Authors: C. D. Hodge; Greg L. Hura

Year: 2020

Venue: The FASEB Journal

DOI: https://doi.org/10.1096/fasebj.2020.34.s1.00627

Paper EXTH-62. Epigenetic priming with DNMT inhibitors enhances CAR T-Cell efficacy in pediatric brain tumors

Lynne El Ghorayeb; Elton Vannoy; Zhongzhen Yi et al. · 2025 · Neuro-Oncology · DOI

Full title: EXTH-62. Epigenetic priming with DNMT inhibitors enhances CAR T-Cell efficacy in pediatric brain tumors

Authors: Lynne El Ghorayeb; Elton Vannoy; Zhongzhen Yi; Kaleem L. Coleman; William Bishop; Katherine B. Chiappinelli; Dalia Haydar

Year: 2025

Venue: Neuro-Oncology

DOI: https://doi.org/10.1093/neuonc/noaf201.1395

Paper IMMU-05. TARGETING THE DYSREGULATED DNA METHYLOME DURING CAR T CELL MANUFACTURING IMPROVES THEIR FITNESS IN IMMUNOCOMPETENT BRAIN TUMOR MODELS

Zhongzhen Yi; Elton Vannoy; Abigail Lee et al. · 2024 · Neuro-Oncology · DOI

Full title: IMMU-05. TARGETING THE DYSREGULATED DNA METHYLOME DURING CAR T CELL MANUFACTURING IMPROVES THEIR FITNESS IN IMMUNOCOMPETENT BRAIN TUMOR MODELS

Authors: Zhongzhen Yi; Elton Vannoy; Abigail Lee; Katherine B. Chiappinelli; Dalia Haydar

Year: 2024

Venue: Neuro-Oncology

DOI: https://doi.org/10.1093/neuonc/noae064.376

Paper TCR-independent Activation in Presence of a Src-family Kinase Inhibitor Improves CAR-T Cell Product Attributes

Gauri Lamture; A. Baer; Joseph W Fischer et al. · 2021 · Journal of immunotherapy · DOI

Full title: TCR-independent Activation in Presence of a Src-family Kinase Inhibitor Improves CAR-T Cell Product Attributes

Authors: Gauri Lamture; A. Baer; Joseph W Fischer; Winston Colon-Moran; N. Bhattarai

Year: 2021

Venue: Journal of immunotherapy

DOI: https://doi.org/10.1097/cji.0000000000000402

Paper Antigen-specific stimulation and expansion of CAR-T cells using membrane vesicles as target cell surrogates

V. Ukrainskaya; Y. Rubtsov; D. Pershin et al. · 2021 · bioRxiv · DOI

Full title: Antigen-specific stimulation and expansion of CAR-T cells using membrane vesicles as target cell surrogates

Authors: V. Ukrainskaya; Y. Rubtsov; D. Pershin; N. Podoplelova; S. Terekhov; R. Kalinin; I. Yaroshevich; A. Sokolova; D. Bagrov; E. Kulakovskaya; V. Shipunova; S. Deyev; E. Maksimov; O. Markov; A. Oshchepkova; M. Zenkova; J. Xie; A. Gabibov; M. Maschan; A. Stepanov; R. Lerner

Year: 2021

Venue: bioRxiv

DOI: https://doi.org/10.1101/2021.03.18.435976

Paper A Novel Generative Mycobacterium Tuberculosis-Specific T Cells Method for Adoptive Cellular Therapy

Juan Zhang; Xiaoqian Ma; Cejun Yang et al. · 2018 · Transplantation · DOI

Full title: A Novel Generative Mycobacterium Tuberculosis-Specific T Cells Method for Adoptive Cellular Therapy

Authors: Juan Zhang; Xiaoqian Ma; Cejun Yang; Q. Fang; Qiong Dong; Wei Wang

Year: 2018

Venue: Transplantation

DOI: https://doi.org/10.1097/01.tp.0000543615.33191.20

Paper A phase I clinical trial of PSMA-directed/TGFβ-insensitive CAR-T cells in metastatic castration-resistant prostate cancer.

Narayan, Vivek; Barber-Rotenberg, Julie S.; Fraietta, Joseph A. et al. · 2021 · Journal of Clinical Oncology · DOI

Full title: A phase I clinical trial of PSMA-directed/TGFβ-insensitive CAR-T cells in metastatic castration-resistant prostate cancer.

Authors: Narayan, Vivek; Barber-Rotenberg, Julie S.; Fraietta, Joseph A.; Hwang, Wei‐Ting; Lacey, Simon F.; Plesa, Gabriela; Carpenter, Erica L.; Maude, Shannon L.; Lal, Priti; Vapiwala, Neha; Melenhorst, J. Joseph; Sebro, Ronnie; Farwell, Michael D.; Moniak, Michael; Gilmore, Joan; Lledo, Lester; Dengel, Karen; June, Carl H.; Haas, Naomi B.

Year: 2021

Venue: Journal of Clinical Oncology

DOI: https://doi.org/10.1200/jco.2021.39.6_suppl.125

Paper Rapid cell expansion (RACE) technology for production of engineered autologous T-cell therapy: Path toward manageable multicenter clinical trials in aggressive NHL with anti-CD19 CAR.

M. Better; O. Pugach; Lily Lu et al. · 2014 · DOI

Full title: Rapid cell expansion (RACE) technology for production of engineered autologous T-cell therapy: Path toward manageable multicenter clinical trials in aggressive NHL with anti-CD19 CAR.

Authors: M. Better; O. Pugach; Lily Lu; R. Somerville; Sadik H. Kassim; J. Kochenderfer; S. Rosenberg; M. Marshall; A. Bot; K. Nolop; M. Roberts; Steven R. Feldman

Year: 2014

DOI: https://doi.org/10.1200/jco.2014.32.15_suppl.3079

Paper Five-year follow-up update of defined-composition CD19 CAR T-cell therapy for relapsed/refractory CLL.

Emily C. Liang; A. Hirayama; E. Kimble et al. · 2023 · Journal of Clinical Oncology · DOI

Full title: Five-year follow-up update of defined-composition CD19 CAR T-cell therapy for relapsed/refractory CLL.

Authors: Emily C. Liang; A. Hirayama; E. Kimble; A. Portuguese; Aya Albittar; A. Chapuis; M. Shadman; B. Till; R. Cassaday; F. Milano; C. Turtle; D. Maloney; J. Gauthier

Year: 2023

Venue: Journal of Clinical Oncology

DOI: https://doi.org/10.1200/jco.2023.41.16_suppl.7511

Paper Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical Trial

Kadauke, Stephan; Myers, Regina M.; Li, Yimei et al. · 2021 · Journal of Clinical Oncology · DOI

Full title: Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical Trial

Authors: Kadauke, Stephan; Myers, Regina M.; Li, Yimei; Aplenc, Richard; Baniewicz, Diane; Barrett, David M.; Leahy, Allison Barz; Callahan, Colleen; Dolan, J. Gregory; Fitzgerald, Julie C.; Gladney, Whitney L.; Lacey, Simon F.; Liu, Hongyan; Maude, Shannon L.; McGuire, Regina; Motley, Laura; Teachey, David T.; Wertheim, Gerald; Wray, Lisa; DiNofia, Amanda M.; Grupp, Stephan A.

Year: 2021

Venue: Journal of Clinical Oncology

DOI: https://doi.org/10.1200/jco.20.02477

Paper Final results from phase I study of PSCA-targeted chimeric antigen receptor (CAR) T cells in patients with metastatic castration resistant prostate cancer (mCRPC).

T. Dorff; S. Blanchard; Hripsime Martirosyan et al. · 2023 · Journal of Clinical Oncology · DOI

Full title: Final results from phase I study of PSCA-targeted chimeric antigen receptor (CAR) T cells in patients with metastatic castration resistant prostate cancer (mCRPC).

Authors: T. Dorff; S. Blanchard; Hripsime Martirosyan; Lauren N. Adkins; Gaurav Dhapola; S. Shishido; J. Wagner; T. Stiller; M. D’Apuzzo; P. Kuhn; S. Forman; S. Priceman

Year: 2023

Venue: Journal of Clinical Oncology

DOI: https://doi.org/10.1200/jco.2023.41.16_suppl.5019

Paper Enhanced anti-tumor activity of CD5 CAR T cells manufactured with tyrosine kinase inhibitors in patients with relapsed/refractory T-ALL.

LaQuisa C. Hill; R. Rouce; Tyler S. Smith et al. · 2023 · Journal of Clinical Oncology · DOI

Full title: Enhanced anti-tumor activity of CD5 CAR T cells manufactured with tyrosine kinase inhibitors in patients with relapsed/refractory T-ALL.

Authors: LaQuisa C. Hill; R. Rouce; Tyler S. Smith; Blakely Boriskie; Madhuwanti Srinivasan; S. Thakkar; Huimin Zhang; B. Mehta; Juntima Sritabal-Ramirez; B. Grilley; H. Heslop; M. Brenner; Maksim Mamonkin

Year: 2023

Venue: Journal of Clinical Oncology

DOI: https://doi.org/10.1200/jco.2023.41.16_suppl.7002

Paper Phase 1 study of DK2

A. Spira, Stanley R. Frankel, S. Fu, S. Kazmi, A. R. Naqash, Xinhua Zhu, Abhishek Tripathi, Alice H Hsu, Julie J. Ahn, Douglas W. Orr, J. Mumm · 2025 · Journal of Clinical Oncology · DOI

Full title: Phase 1 study of DK2

Authors: A. Spira, Stanley R. Frankel, S. Fu, S. Kazmi, A. R. Naqash, Xinhua Zhu, Abhishek Tripathi, Alice H Hsu, Julie J. Ahn, Douglas W. Orr, J. Mumm

Year: 2025

Venue: Journal of Clinical Oncology

DOI: https://doi.org/10.1200/jco.2025.43.16_suppl.2589

Paper Efficient and Rapid Generation of CAR-T and Cytokine-Induced Killer Cells in GMP-scalable Devices.

G. D’accardio; H. T. Ngo; E. Vigolo et al. · 2025 · Journal of Visualized Experiments · DOI

Full title: Efficient and Rapid Generation of CAR-T and Cytokine-Induced Killer Cells in GMP-scalable Devices.

Authors: G. D’accardio; H. T. Ngo; E. Vigolo; R. Sommaggio; P. Palmerini; Sara Boscarato; E. Cappuzzello; Antonio Rosato

Year: 2025

Venue: Journal of Visualized Experiments

DOI: https://doi.org/10.3791/69369

Paper Technological and Manufacturing Innovation Drive Improved Access to Engineered T Cell Therapies

Ying Xiong; Yanping Xie; Zhongyu Zhu et al. · 2023 · Medical Research Archives · DOI

Full title: Technological and Manufacturing Innovation Drive Improved Access to Engineered T Cell Therapies

Authors: Ying Xiong; Yanping Xie; Zhongyu Zhu; Ibeawuchi Oparaocha; Oxana Sleesareva; B. Dropulić; R. Orentas

Year: 2023

Venue: Medical Research Archives

DOI: https://doi.org/10.18103/mra.v11i11.4759

Paper Worth the switch? Enhancing process performance for cell therapy manufacturing with an animal component-free raw material strategy

Phil Morton; Shanya Jiang · 2025 · Cell and Gene Therapy Insights · DOI

Full title: Worth the switch? Enhancing process performance for cell therapy manufacturing with an animal component-free raw material strategy

Authors: Phil Morton; Shanya Jiang

Year: 2025

Venue: Cell and Gene Therapy Insights

DOI: https://doi.org/10.18609/cgti.2025.011

Paper Using serum-free media to streamline and optimize CAR T-cell manufacturing workflows

Chengkang Zhang; Amber Jones · 2020 · Cell and Gene Therapy Insights · DOI

Full title: Using serum-free media to streamline and optimize CAR T-cell manufacturing workflows

Authors: Chengkang Zhang; Amber Jones

Year: 2020

Venue: Cell and Gene Therapy Insights

DOI: https://doi.org/10.18609/cgti.2020.121

Paper The cell therapy industrial revolution: current successes, existing challenges, and expansion into new domains

J. Gaston; Matthew Li · 2024 · Cell and Gene Therapy Insights · DOI

Full title: The cell therapy industrial revolution: current successes, existing challenges, and expansion into new domains

Authors: J. Gaston; Matthew Li

Year: 2024

Venue: Cell and Gene Therapy Insights

DOI: https://doi.org/10.18609/cgti.2024.135

Paper Enhancing CAR-T therapy development: harnessing cell selection flexibility

Tamara Laskowski; Nuala Trainor · 2025 · Cell and Gene Therapy Insights · DOI

Full title: Enhancing CAR-T therapy development: harnessing cell selection flexibility

Authors: Tamara Laskowski; Nuala Trainor

Year: 2025

Venue: Cell and Gene Therapy Insights

DOI: https://doi.org/10.18609/cgti.2025.013

Paper Individual and synergistic cytokine effects controlling the expansion of cord blood CD34(+) cells and megakaryocyte progenitors in culture.

N. Pineault; Valérie Cortin; L. Boyer et al. · 2011 · Cytotherapy · DOI

Full title: Individual and synergistic cytokine effects controlling the expansion of cord blood CD34(+) cells and megakaryocyte progenitors in culture.

Authors: N. Pineault; Valérie Cortin; L. Boyer; A. Garnier; A. Robert; C. Thérien; D. Roy

Year: 2011

Venue: Cytotherapy

DOI: https://doi.org/10.3109/14653249.2010.530651

Paper New technologies to improve CAR T cell generation and biomanufacturing will lead to safer, more therapeutically effective cells

Moataz Dowaidar · 2021 · DOI

Full title: New technologies to improve CAR T cell generation and biomanufacturing will lead to safer, more therapeutically effective cells

Authors: Moataz Dowaidar

Year: 2021

DOI: https://doi.org/10.31219/osf.io/un8gp

Paper Metabolic Regulation of CAR T Cell Function by the Hypoxic Microenvironment in Solid Tumors

Schurich, Anna; Magalhaes, Isabelle; Mattsson, Jonas · 2019 · Immunotherapy · DOI

Full title: Metabolic Regulation of CAR T Cell Function by the Hypoxic Microenvironment in Solid Tumors

Authors: Schurich, Anna; Magalhaes, Isabelle; Mattsson, Jonas

Year: 2019

Venue: Immunotherapy

DOI: https://doi.org/10.2217/imt-2018-0141

Paper A Phase 1 Dose Escalation Trial of Third Generation Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed and Refractory B-Cell Non Hodgkin Lymphoma

P. George · DOI

Full title: A Phase 1 Dose Escalation Trial of Third Generation Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed and Refractory B-Cell Non Hodgkin Lymphoma

Authors: P. George

DOI: https://doi.org/10.26686/wgtn.17148182.v1

Paper Advancing NK Cell Therapies: Expansion and Activation for Next-Generation Immunotherapy

Dinesh Kumar; Rajni Tanwar · 2025 · Current Cancer Therapy Reviews · DOI

Full title: Advancing NK Cell Therapies: Expansion and Activation for Next-Generation Immunotherapy

Authors: Dinesh Kumar; Rajni Tanwar

Year: 2025

Venue: Current Cancer Therapy Reviews

DOI: https://doi.org/10.2174/0115733947383194250701073137

Paper Preclinical development of a humanized chimeric antigen receptor against B-cell maturation antigen for multiple myeloma

Lorena Pérez-Amill; Guillermo Suñé; A. Antoñana-Vildosola et al. · 2020 · Haematologica · DOI

Full title: Preclinical development of a humanized chimeric antigen receptor against B-cell maturation antigen for multiple myeloma

Authors: Lorena Pérez-Amill; Guillermo Suñé; A. Antoñana-Vildosola; M. Castellà; A. Najjar; J. Bonet; N. Fernández-Fuentes; S. Inogés; Ascensión López; C. Bueno; M. Juan; Á. Urbano-Ispizua; B. Martín-Antonio

Year: 2020

Venue: Haematologica

DOI: https://doi.org/10.3324/haematol.2019.228577

Paper Ex Vivo Expansion of Highly Cytotoxic Natural Killer Cells Using Optimal Culture Medium

Seokho Kim · 2022 · Annals of Laboratory Medicine · DOI

Full title: Ex Vivo Expansion of Highly Cytotoxic Natural Killer Cells Using Optimal Culture Medium

Authors: Seokho Kim

Year: 2022

Venue: Annals of Laboratory Medicine

DOI: https://doi.org/10.3343/alm.2022.42.6.619

Paper Cytokine Profile Following Varnimcabtagene Autoleucel (IMN-003A) in Patients with Relapsed Refractory B Cell Malignancies in the First-in-India Industry Phase-2 Study (IMAGINE)

S. Damodar; Sunil Bhat; R. Thirumalairaj et al. · 2023 · Blood · DOI

Full title: Cytokine Profile Following Varnimcabtagene Autoleucel (IMN-003A) in Patients with Relapsed Refractory B Cell Malignancies in the First-in-India Industry Phase-2 Study (IMAGINE)

Authors: S. Damodar; Sunil Bhat; R. Thirumalairaj; Pankaj Malhotra; S. Dhar; Sandeepa Shetty; Mani Bharathi T.I.; A. Joseph; Gowri Shankar Krishnan; Pallavi Arasu; Sri Ramulu Elluru; M. Akheel; Rahul Nahar; Lakshmikanth Gandikota; Anil Kamat

Year: 2023

Venue: Blood

DOI: https://doi.org/10.1182/blood-2023-181585

Paper New Optimized Academic Anti-BCMA CAR (CARTemis-1): How Does the Manufacturing Process Impact CAR-T Cell Features?

Belén Sierro-Martínez; Virginia Escamilla Gómez; Laura Pérez-Ortega et al. · 2023 · Blood · DOI

Full title: New Optimized Academic Anti-BCMA CAR (CARTemis-1): How Does the Manufacturing Process Impact CAR-T Cell Features?

Authors: Belén Sierro-Martínez; Virginia Escamilla Gómez; Laura Pérez-Ortega; Beatriz Guijarro-Albaladejo; Paola Hernández-Díaz; María de la Rosa-Garrido; Maribel Lara-Chica; J. L. Reguera; Luzalba Sanoja Flores; Blanca Arribas-Arribas; M. Montiel-Aguilera; Gloria Carmona; Maria-Jose Robles; T. Caballero; Javier Briones; H. Einsele; M. Hudecek; J. Pérez-Simón; Estefanía García-Guerrero

Year: 2023

Venue: Blood

DOI: https://doi.org/10.1182/blood-2023-186095

Paper Heme Attenuates T Cell Exhaustion and Drives Effector Function: Implications for Immune and Adoptive T Cell Therapy

Pulkit Gupta; Heather K. Lin; Remya Nair et al. · 2023 · Blood · DOI

Full title: Heme Attenuates T Cell Exhaustion and Drives Effector Function: Implications for Immune and Adoptive T Cell Therapy

Authors: Pulkit Gupta; Heather K. Lin; Remya Nair; Ruby Freeman; Dejah A Blake; Kiran Lakhani; Doris R. Powell; S. Lonial; B. Barwick; A. Nooka; S. Rafiq; Mala Shanmugam

Year: 2023

Venue: Blood

DOI: https://doi.org/10.1182/blood-2023-186634

Paper Functionality and Cell Senescence of CD4/ CD8-Selected CD20 CAR T Cells Manufactured Using the Automated CliniMACS Prodigy® Platform

K. Aleksandrova; J. Leise; C. Priesner et al. · 2019 · Transfusion Medicine and Hemotherapy · DOI

Full title: Functionality and Cell Senescence of CD4/ CD8-Selected CD20 CAR T Cells Manufactured Using the Automated CliniMACS Prodigy® Platform

Authors: K. Aleksandrova; J. Leise; C. Priesner; A. Melk; Fanni Kubaink; H. Abken; A. Hombach; M. Aktas; M. Essl; I. Bürger; A. Kaiser; G. Rauser; M. Jurk; L. Goudeva; W. Glienke; L. Arseniev; R. Esser; U. Köhl

Year: 2019

Venue: Transfusion Medicine and Hemotherapy

DOI: https://doi.org/10.1159/000495772

Paper Varnimcabtagene Autoleucel (IMN-003A): Differences in T Cell Subset Phenotype in B-ALL and B-NHL Cohorts Did Not Influence Efficacy Outcomes in the Phase-2 Study (IMAGINE)

Sunil Bhat; S. Damodar; R. Thirumalairaj et al. · 2023 · Blood · DOI

Full title: Varnimcabtagene Autoleucel (IMN-003A): Differences in T Cell Subset Phenotype in B-ALL and B-NHL Cohorts Did Not Influence Efficacy Outcomes in the Phase-2 Study (IMAGINE)

Authors: Sunil Bhat; S. Damodar; R. Thirumalairaj; Pankaj Malhotra; Alex Jose Pulikkottil; J. Kumar; Melina Soares; S. Dhar; Sandeepa Shetty; Mani Bharathi T.I.; G. Jakka; A. Joseph; Arun Kumar Mg; Pallavi Arasu; Sri Ramulu Elluru; M. Akheel; Giridhar Chenji; Lakshmikanth Gandikota; Rahul Nahar; Anil Kamat

Year: 2023

Venue: Blood

DOI: https://doi.org/10.1182/blood-2023-184521

Paper As Fast As We Can: Rational Design of Rapid Chimeric Antigen Receptor T Cell Manufacturing

Pengfei Jiang; Shih-Ting Cao; Haiying Wang et al. · 2023 · Blood · DOI

Full title: As Fast As We Can: Rational Design of Rapid Chimeric Antigen Receptor T Cell Manufacturing

Authors: Pengfei Jiang; Shih-Ting Cao; Haiying Wang; Qinghui Xiong; Mingyuan Gu; Chengbing Fu; Xiu Li; Mian Zhang; Na Li; Jing Li; Xin Xu; Yiwei Gong

Year: 2023

Venue: Blood

DOI: https://doi.org/10.1182/blood-2023-188144

Paper Breaking Barriers in B-Acute Lymphoblastic Leukemia Treatment: Experience of a Tertiary Hospital with the Use of a Tandem Dual CAR-T 19/22 in Pediatric & AYA Patients

Berta González-Martínez; Víctor Galán-Gómez; Jordi Minguillon Pedreno et al. · 2023 · Blood · DOI

Full title: Breaking Barriers in B-Acute Lymphoblastic Leukemia Treatment: Experience of a Tertiary Hospital with the Use of a Tandem Dual CAR-T 19/22 in Pediatric & AYA Patients

Authors: Berta González-Martínez; Víctor Galán-Gómez; Jordi Minguillon Pedreno; A. Navarro-Zapata; Isabel Mirones-Aguilar; E. Sánchez-Zapardiel; Carlos Echecopar; Isabel Martínez-Romera; Antonio Pérez-Martínez

Year: 2023

Venue: Blood

DOI: https://doi.org/10.1182/blood-2023-188783

Paper Development and Clinical Validation of an Ultra-Fast CAR-T Manufacturing Platform Enabling Production of CAR-T Cells in Less Than 1 Day

Ryan Stadel; Nethrie D. Idippily; Maria Florencia Giraudo et al. · 2023 · Blood · DOI

Full title: Development and Clinical Validation of an Ultra-Fast CAR-T Manufacturing Platform Enabling Production of CAR-T Cells in Less Than 1 Day

Authors: Ryan Stadel; Nethrie D. Idippily; Maria Florencia Giraudo; P. Caimi; K. van Besien; James Martin; John Wu; Changchun Deng; David N. Wald

Year: 2023

Venue: Blood

DOI: https://doi.org/10.1182/blood-2023-188214

Paper Initial Experience with CD19/CD22 BiCistronic CAR T-Cells in Children and Young Adults with Recurrent or Refractory B-Cell Malignancies

Brynn B. Duncan; Sara K Silbert; Alexander W Rankin et al. · 2024 · Blood · DOI

Full title: Initial Experience with CD19/CD22 BiCistronic CAR T-Cells in Children and Young Adults with Recurrent or Refractory B-Cell Malignancies

Authors: Brynn B. Duncan; Sara K Silbert; Alexander W Rankin; B. Yates; Lauren Little; Toni Foley; Hao-Wei Wang; C. Yuan; Dana I. Delgado Colon; Yanyu Wang; Jon Inglefield; John A Ligon; Hannah W Song; S. Highfill; Haneen Shalabi; David F. Stroncek; Naomi Taylor; Nirali N. Shah

Year: 2024

Venue: Blood

DOI: https://doi.org/10.1182/blood-2024-198259

Paper Clinical Response after Allogeneic CAR T Cell Therapy Is Linked to Expansion of Identical CD8+ Effector-like T Cell Clones

A. Jallouk; Zhongqi Ge; Vivek Kaimal et al. · 2024 · Blood · DOI

Full title: Clinical Response after Allogeneic CAR T Cell Therapy Is Linked to Expansion of Identical CD8+ Effector-like T Cell Clones

Authors: A. Jallouk; Zhongqi Ge; Vivek Kaimal; Paul B. Robbins; Zachary J. Roberts; S. Neelapu; P. Bachireddy

Year: 2024

Venue: Blood

DOI: https://doi.org/10.1182/blood-2024-197969

Paper Venetoclax Pre-Treatment of CLL/SLL Patients Enhances Autologous CAR T-Cells Efficacy

M. Cortese; C. Mavis; Taylor K Mandeville et al. · 2023 · Blood · DOI

Full title: Venetoclax Pre-Treatment of CLL/SLL Patients Enhances Autologous CAR T-Cells Efficacy

Authors: M. Cortese; C. Mavis; Taylor K Mandeville; J. Gu; Kevin Bowman; F. Hernandez-Ilizaliturri

Year: 2023

Venue: Blood

DOI: https://doi.org/10.1182/blood-2023-189733

Paper Prolonged Persistence and Functional Activity of Anti-BCMA CAR-T Durcabtagene Autoleucel (PHE885) Manufactured Using the T-Charge™ Platform

Shuntaro Ikegawa; A. Sperling; S. Nikiforow et al. · 2024 · Blood · DOI

Full title: Prolonged Persistence and Functional Activity of Anti-BCMA CAR-T Durcabtagene Autoleucel (PHE885) Manufactured Using the T-Charge™ Platform

Authors: Shuntaro Ikegawa; A. Sperling; S. Nikiforow; Andrew Ghazi; Anthony Christidis; David Quinn; D. Bu; J. Mataraza; David Pearson; Allison Charles; M. Credi; Nina Orwitz; Madisyn Strange; Rakuyo Tamada; Kevin M Panaro; Casey Gervais; Michela Ansuinelli; Y. Arihara; R. Prabhala; Carol G. Reynolds; Robert Gentleman; S. Vita; Nikhil C Munshi; Jerome Ritz

Year: 2024

Venue: Blood

DOI: https://doi.org/10.1182/blood-2024-199890

Paper Innovative Bone Marrow CAR-T Cell Manufacturing for AML: Enhancing Viability and Tumor Migration

Jose Antonio Bejarano Garcia; D. Primo; Maria Jose Palacios Barea et al. · 2024 · Blood · DOI

Full title: Innovative Bone Marrow CAR-T Cell Manufacturing for AML: Enhancing Viability and Tumor Migration

Authors: Jose Antonio Bejarano Garcia; D. Primo; Maria Jose Palacios Barea; Belén Sierro; Beatriz Guijarro-Albaladejo; Xian Weng; Miranda Omenaca; Estefanía García-Guerrero; J. Ballesteros; J. Pérez-Simón

Year: 2024

Venue: Blood

DOI: https://doi.org/10.1182/blood-2024-201457

Paper Assessing CAR-T Cell Product Quality: The Crucial Role of Metabolic and Persistence Analysis after Antigen Stimulation

Beatriz Guijarro-Albaladejo; Belén Sierro; Virginia Escamilla Gómez et al. · 2024 · Blood · DOI

Full title: Assessing CAR-T Cell Product Quality: The Crucial Role of Metabolic and Persistence Analysis after Antigen Stimulation

Authors: Beatriz Guijarro-Albaladejo; Belén Sierro; Virginia Escamilla Gómez; Paola Hernández-Díaz; María de la Rosa-Garrido; Inmaculada Carrasco Brocal; Jose Antonio Bejarano Garcia; Patricia Alcalde Mellado; Alfonso Rodriguez Gil; Maribel Lara-Chica; J. Pérez-Simón; Estefanía García-Guerrero

Year: 2024

Venue: Blood

DOI: https://doi.org/10.1182/blood-2024-204757

Paper Enhancing CAR-T Therapy in CLL By Modulating the Immunosuppressive Tumor Microenvironment: A Novel Approach with Significant Therapeutic Potential

Angimar Uriepero Palma; Melanie Mediavilla Varela; Maria Elena Marquez et al. · 2024 · Blood · DOI

Full title: Enhancing CAR-T Therapy in CLL By Modulating the Immunosuppressive Tumor Microenvironment: A Novel Approach with Significant Therapeutic Potential

Authors: Angimar Uriepero Palma; Melanie Mediavilla Varela; Maria Elena Marquez; Wael Gamal; Mohammad Ammad-Ud-Din; P. Oppezzo; E. Sahakian; J. Pinilla-Ibarz

Year: 2024

Venue: Blood

DOI: https://doi.org/10.1182/blood-2024-204892

Paper Modulating the Vasoactive Intestinal Peptide (VIP) Pathway Reprograms Superior CAR T Cells

Heather K. Lin; Dejah A Blake; Kory Wells et al. · 2024 · Blood · DOI

Full title: Modulating the Vasoactive Intestinal Peptide (VIP) Pathway Reprograms Superior CAR T Cells

Authors: Heather K. Lin; Dejah A Blake; Kory Wells; Ruby Freeman; A. Mudigonda; William Liu; A. Evans; Subir Goyal; Tongrui Liu; C. R. Funk; T. Sinha; Elyse L. Christensen; Naeman Mahmood; Fan Fei; Brad Heller; Paul Chun; Tenzin Passang; S. Ravindranathan; Jodi Dougan; Christopher C. Porter; Chrystal M. Paulos; A. Patgiri; Lily Yang; Edmund K. Waller; S. Rafiq

Year: 2024

Venue: Blood

DOI: https://doi.org/10.1182/blood-2024-208090

Paper iPSC-Derived CAR-Gamma Delta T with Novel Combinatorial KO Demonstrated Extended Longevity and Profound Anti-Tumor Efficacy without Cytokine Support in Preclinical Studies

Jhang-Sian Yu; Chia-Hung Lin; Ying-Tsen Tung et al. · 2024 · Blood · DOI

Full title: iPSC-Derived CAR-Gamma Delta T with Novel Combinatorial KO Demonstrated Extended Longevity and Profound Anti-Tumor Efficacy without Cytokine Support in Preclinical Studies

Authors: Jhang-Sian Yu; Chia-Hung Lin; Ying-Tsen Tung; Fang-Pei Chang; Edward Po-Fan Chu; Shiou-Ling Jian; Fu-Fei Hsu; Ming-Chin Ko; Yi-Han Dai; Chieh-Teng Cheng; Tzu-Chien Kuo; I-Ting Chen; Ting-Yi Wu; Jin-Yi Lu; Ke-Hsun Hsu; Wei-Ting Chen; Darien Zhing Herr Chan; Yi-Ting Lai; Shao-Ju Weng; Liang-Yi Chen; Yuan-Yu Hsia; Yi-Hung Ou; Yo-Chuen Lin; Shih-Wen Huang; Yu-Chih Peng; Chien-Hsi Chen; Chien-Yu Hsu; Yi-Ting Lai; Chih-Lung Chen; Chun-Yu Lin; Lin-Yu Liao; Wan-Chen Tsai; Hsin-Hua Cho; Cheng-Kai Wang; Lee-Yieng Lim; Ji-Kuan Wang; Yao-Yu Chen; Chih-Kai Yin; Wen-Hao Wang; Tsung-Hao Yeh; Min-Ren Chiang; Ruyue Ji; J. Chi; Lien-Szu Wu; Jennifer Huang; De-Kuan Chang; Alex Shih-Min Huang

Year: 2024

Venue: Blood

DOI: https://doi.org/10.1182/blood-2024-205086

Paper Euplagia-1: A Phase 1/2 Trial of GLPG5201, a Fresh Stem-like Early Memory CD19 CAR T-Cell Therapy with a 7-Day Vein-to-Vein Time, in Patients with Relapsed/Refractory CLL and RT

V. Ortiz-Maldonado; N. Martínez-Cibrian; L. Alserawan et al. · 2024 · Blood · DOI

Full title: Euplagia-1: A Phase 1/2 Trial of GLPG5201, a Fresh Stem-like Early Memory CD19 CAR T-Cell Therapy with a 7-Day Vein-to-Vein Time, in Patients with Relapsed/Refractory CLL and RT

Authors: V. Ortiz-Maldonado; N. Martínez-Cibrian; L. Alserawan; Sergi Betriu; Ana Triguero; S. Blum; M. Faes; Marte C. Liefaard; Margot J. Pont; Maike Spoon; K. Van Hoorde; Anna D. D. van Muyden; Julio Delgado; N. Tovar

Year: 2024

Venue: Blood

DOI: https://doi.org/10.1182/blood-2024-207546

Paper In Vivo Persistence and Function of CAR19 T-Cell Products for Pediatric B-Cell Acute Lymphoblastic Leukemia Are Impacted By Media, Cytokine Supplementation and Metabolite Bioavailability during Ex Vivo Manufacturing

Caitlin R. Hopkins; Amanda M DiNofia; S. Maude et al. · 2024 · Blood · DOI

Full title: In Vivo Persistence and Function of CAR19 T-Cell Products for Pediatric B-Cell Acute Lymphoblastic Leukemia Are Impacted By Media, Cytokine Supplementation and Metabolite Bioavailability during Ex Vivo Manufacturing

Authors: Caitlin R. Hopkins; Amanda M DiNofia; S. Maude; Gregory Chen; Kwame Attah M. Boateng-Antwi; Jessica Perazzelli; Andres F. Mendez Corea; Alexander Shestov; M. Gohil; Yimei Li; Wei-Ting Hwang; Bakir Valentić; Shannon Christensen; J. Jadlowsky; R. Myers; C. Diorio; M. Davis; Theresa Colligon; G. Plesa; Don L. Siegel; Bruce L. Levine; Carl H June; Roddy S. O’Connor; S. Grupp; J. Fraietta

Year: 2024

Venue: Blood

DOI: https://doi.org/10.1182/blood-2024-210324

Paper A Novel Platform Technology for the Development of NK Cell-Based Cellular Immunotherapies

Ammelie Svea Boje; Anna Langner; C. Gehlert et al. · 2024 · Blood · DOI

Full title: A Novel Platform Technology for the Development of NK Cell-Based Cellular Immunotherapies

Authors: Ammelie Svea Boje; Anna Langner; C. Gehlert; C. Reitinger; Falk Nimmerjahn; E. M. Murga Penas; S. Bendig; G. Chitadze; Monika Brüggemann; Katharina Diemer; Alexander Jochimsen; D. Winterberg; Natalie Baum; S. Krohn; T. Valerius; F. Stölzel; M. Gramatzki; Katja Klausz; Christian Kellner; M. Peipp

Year: 2024

Venue: Blood

DOI: https://doi.org/10.1182/blood-2024-210243

Paper Surveying Local CAR-T Manufacturing Processes to Promote Standardization of Protocols

D. Gupta; B. Shaz · 2024 · Blood · DOI

Full title: Surveying Local CAR-T Manufacturing Processes to Promote Standardization of Protocols

Authors: D. Gupta; B. Shaz

Year: 2024

Venue: Blood

DOI: https://doi.org/10.1182/blood-2024-210502

Paper Multiomic Evaluation of Immunologic Changes in Chronic Lymphocytic Leukemia with Venetoclax Treatment

Matthew J. Cortese, MD, MPH; Jacob P Wright; C. Mavis et al. · 2024 · Blood · DOI

Full title: Multiomic Evaluation of Immunologic Changes in Chronic Lymphocytic Leukemia with Venetoclax Treatment

Authors: Matthew J. Cortese, MD, MPH; Jacob P Wright; C. Mavis; Taylor K Mandeville; Alex Niu; Dae-Kyum Kim; Spencer Rosario; F. Hernandez-Ilizaliturri

Year: 2024

Venue: Blood

DOI: https://doi.org/10.1182/blood-2024-212019

Paper A Phase 1 Study of NKX019, an Allogeneic Chimeric Antigen Receptor Natural Killer (CAR-NK) Cell Therapy in Patients with Systemic Lupus Erythematosus

A. Askanase; L. Khalili; Cornell Chang et al. · 2024 · Blood · DOI

Full title: A Phase 1 Study of NKX019, an Allogeneic Chimeric Antigen Receptor Natural Killer (CAR-NK) Cell Therapy in Patients with Systemic Lupus Erythematosus

Authors: A. Askanase; L. Khalili; Cornell Chang; Alison Blaus; Phung Gip; Elaine Karis; David Shook

Year: 2024

Venue: Blood

DOI: https://doi.org/10.1182/blood-2024-212347

Paper iPSC-derived, multiplex-engineered CD8αβT cells deliver antigen-specific, potent, and durable tumor cytotoxicity without CD4αβT support – powering scalable, off-the-shelf allogeneic αβT cell therapy in hematological malignancies

Chih-Lung Chen; Jhang-Sian Yu; Chia-Hung Lin et al. · 2025 · Blood · DOI

Full title: iPSC-derived, multiplex-engineered CD8αβT cells deliver antigen-specific, potent, and durable tumor cytotoxicity without CD4αβT support – powering scalable, off-the-shelf allogeneic αβT cell therapy in hematological malignancies

Authors: Chih-Lung Chen; Jhang-Sian Yu; Chia-Hung Lin; Po-Fan Chu; Lin-Yu Liao; Wan-Chen Tsai; Yi-Han Dai; Ming-Chin Ko; Annie Yi-Ting Lai; Chun-Yu Lin; Wei-Ting Chen; Ying-Tsen Tung; Kuan-Hung Chen; Shao-Ju Weng; Pei-Kai Chen; Yi-Chiao Tseng; Ke-Hsun Hsu; Fang-Pei Chang; Fu-Fei Hsu; Yi-Ting Lai; Shiou-Ling Jian; Chien-Yu Hsu; Darien Zhing Herr Chan; Yo-Chuen Lin; Jin-Yi Lu; Hsin-Hua Cho; Cheng-Kai Wang; Lee-Yieng Lim; Tzu-Chien Kuo; Yun Gao; Pei-Chun Wu; Ta-Hsun Liao; Lien-Szu Wu; J. Chi; Ching-Ying Huang; Ao Hu; MinHong Yan; Haitao Wang; Alex Shih-Min Huang

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood-2025-2327

Paper Short-term IL-21 and GSK-3β inhibition enriches stem-like CD8⁺ T cells and boosts CD19 CAR T-cell effector function

Takeshi Ito; Makoto Ando; J. Moraly et al. · 2025 · Blood · DOI

Full title: Short-term IL-21 and GSK-3β inhibition enriches stem-like CD8⁺ T cells and boosts CD19 CAR T-cell effector function

Authors: Takeshi Ito; Makoto Ando; J. Moraly; W. Linehan; Daniel Crooks; Naomi Taylor

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood-2025-1046

Paper Pharmacologic drugging of BCL-2 during manufacturing restores T cell fitness and enhances CART efficacy

Nada S Aboelella; Ryan Park; Erting Tang et al. · 2025 · Blood · DOI

Full title: Pharmacologic drugging of BCL-2 during manufacturing restores T cell fitness and enhances CART efficacy

Authors: Nada S Aboelella; Ryan Park; Erting Tang; Nick Asby; Joshua Ho; Tony Pan; S. Wang; Lishi Xie; J. Kline; Peter A Riedell; Jun Huang; James LaBelle

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood-2025-1047

Paper CD371-Targeted CAR T cells Secreting Interleukin-18 Exhibit Robust Expansion and Clear Refractory Acute Myeloid Leukemia.

Mark B. Geyer; Susan DeWolf; Xiaoli Mi et al. · 2025 · Blood · DOI

Full title: CD371-Targeted CAR T cells Secreting Interleukin-18 Exhibit Robust Expansion and Clear Refractory Acute Myeloid Leukemia.

Authors: Mark B. Geyer; Susan DeWolf; Xiaoli Mi; Kenyon Weis; B. Shaffer; Briana Cadzin; D. McAvoy; Zoe A Katsamakis; Rachel Lorenc; Alexander M Lewis; Brianna Gipson; M. A. Cuibus; Narina N. Girotra; Kenton Wu; N. Smith; Erin Burns; Jasmine Um; Sarah Yoo; Behzad Kharabi Masouleh; Pallavi Galera; K. Hosszu; Jagrutiben Chaudhari; Xiuyan Wang; Qianqian Lin; K. Curran; Jae-Hyun Park; D. Scheinberg; Marcel R. M. van den Brink; Omar Abdel-Wahab; R. Brentjens; A. Daniyan

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood.2025029532

Paper A first-in-primate In Vivo CRISPR/Cas9 screen in a rhesus macaque model identifies drivers of CAR-T expansion, tissue tropism and persistence

Francesca Alvarez Calderon; Marlana B Winschel; Smriti Srikanth et al. · 2025 · Blood · DOI

Full title: A first-in-primate In Vivo CRISPR/Cas9 screen in a rhesus macaque model identifies drivers of CAR-T expansion, tissue tropism and persistence

Authors: Francesca Alvarez Calderon; Marlana B Winschel; Smriti Srikanth; Marc Schwartz; R. Fleming; Lev Gorfinkel; Rachel Hu; Casey Son; John Doench; Leslie S. Kean; Ulrike Gerdemann

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood-2025-2329

Paper Dasatinib enhances potency of a novel CD123 CAR against AML by improving cell fitness

Genqing Liang; Peirong Hu; Ngoc Q Tran et al. · 2025 · Blood · DOI

Full title: Dasatinib enhances potency of a novel CD123 CAR against AML by improving cell fitness

Authors: Genqing Liang; Peirong Hu; Ngoc Q Tran; Brittany L. Steimle; Alun J Carter; R. Orentas

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood-2025-2326

Paper - **DOI:** 10.1158/2326-6074.tumimm24-a024 - **Authors:** Alok Kumar, Dayana B. Rivadeneira, Alison Kohan, Greg M. Delgoffe - **Year:** 2024 - **Journal:** Cancer immunology research

Alok Kumar; Dayana B. Rivadeneira; Alison Kohan et al. · 2024 · Cancer immunology research · DOI

Full title: - **DOI:** 10.1158/2326-6074.tumimm24-a024 - **Authors:** Alok Kumar, Dayana B. Rivadeneira, Alison Kohan, Greg M. Delgoffe - **Year:** 2024 - **Journal:** Cancer immunology research

Authors: Alok Kumar; Dayana B. Rivadeneira; Alison Kohan; Greg M. Delgoffe

Year: 2024

Venue: Cancer immunology research

DOI: https://doi.org/10.1158/2326-6074.tumimm24-a024

Paper B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma.

Adam D. Cohen; A. Garfall; E. Stadtmauer et al. · 2019 · Journal of Clinical Investigation · DOI

Full title: B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma.

Authors: Adam D. Cohen; A. Garfall; E. Stadtmauer; J. Melenhorst; S. Lacey; E. Lancaster; D. Vogl; Brendan M. Weiss; Karen Dengel; A. Nelson; G. Plesa; Fang Chen; M. Davis; W. Hwang; R. Young; J. Brogdon; R. Isaacs; Iulian Pruteanu-Malinici; Don L. Siegel; Bruce L. Levine; Carl H. June; Michael C. Milone

Year: 2019

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci126397

Paper Efficient Chimeric Antigen Receptor T-Cell Generation Starting with Leukoreduction System Chambers of Thrombocyte Apheresis Sets

Stefani Xhaxho; L. Chen-Wichmann; Sophie Kreissig et al. · 2023 · Transfusion Medicine and Hemotherapy · DOI

Full title: Efficient Chimeric Antigen Receptor T-Cell Generation Starting with Leukoreduction System Chambers of Thrombocyte Apheresis Sets

Authors: Stefani Xhaxho; L. Chen-Wichmann; Sophie Kreissig; R. Windisch; A. Gottschlich; Sayantan Nandi; Sophie Schabernack; Irmgard Kohler; Christian Kellner; S. Kobold; Andreas Humpe; Christian Wichmann

Year: 2023

Venue: Transfusion Medicine and Hemotherapy

DOI: https://doi.org/10.1159/000532130

Paper BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models

Kagoya, Yuki; Nakatsugawa, Munehide; Yamashita, Yūki et al. · 2016 · Journal of Clinical Investigation · DOI

Full title: BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models

Authors: Kagoya, Yuki; Nakatsugawa, Munehide; Yamashita, Yūki; Ochi, Toshiki; Guo, Tingxi; Anczurowski, Mark; Saso, Kayoko; Butler, Marcus O.; Arrowsmith, C.H.; Hirano, Naoto

Year: 2016

Venue: Journal of Clinical Investigation

DOI: https://doi.org/10.1172/jci86437

Paper Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor

Jena, Bipulendu; Dotti, Gianpietro; Cooper, Laurence J.N. · 2010 · Blood · DOI

Full title: Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor

Authors: Jena, Bipulendu; Dotti, Gianpietro; Cooper, Laurence J.N.

Year: 2010

Venue: Blood

DOI: https://doi.org/10.1182/blood-2010-01-043737

Paper Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation

Micklethwaite, Kenneth; Savoldo, Barbara; Hanley, Patrick J. et al. · 2010 · Blood · DOI

Full title: Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation

Authors: Micklethwaite, Kenneth; Savoldo, Barbara; Hanley, Patrick J.; Leen, Ann M.; Demmler‐Harrison, Gail J.; Cooper, Laurence J.N.; Liu, Hao; Gee, Adrian P.; Shpall, Elizabeth J.; Rooney, Cliona M.; Heslop, Helen E.; Brenner, Malcolm K.; Bollard, Catherine M.; Dotti, Gianpietro

Year: 2010

Venue: Blood

DOI: https://doi.org/10.1182/blood-2009-09-242263

Paper Deterministic Lateral Displacement: The Next-Generation CAR T-Cell Processing?

R. Campos-González; A. Skelley; Khushroo Gandhi et al. · 2018 · SLAS technology · DOI

Full title: Deterministic Lateral Displacement: The Next-Generation CAR T-Cell Processing?

Authors: R. Campos-González; A. Skelley; Khushroo Gandhi; D. Inglis; J. Sturm; C. Civin; T. Ward

Year: 2018

Venue: SLAS technology

DOI: https://doi.org/10.1177/2472630317751214

Paper CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia

Maude, Shannon L.; Teachey, David T.; Porter, David L. et al. · 2015 · Blood · DOI

Full title: CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia

Authors: Maude, Shannon L.; Teachey, David T.; Porter, David L.; Grupp, Stephan A.

Year: 2015

Venue: Blood

DOI: https://doi.org/10.1182/blood-2014-12-580068

Paper Optimizing T-cell receptor gene therapy for hematologic malignancies

Morris, Emma; Stauss, Hans J. · 2016 · Blood · DOI

Full title: Optimizing T-cell receptor gene therapy for hematologic malignancies

Authors: Morris, Emma; Stauss, Hans J.

Year: 2016

Venue: Blood

DOI: https://doi.org/10.1182/blood-2015-11-629071

Paper Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor–modified T-cell therapy

Hay, Kevin A.; Hanafi, Laïla‐Aïcha; Li, Daniel et al. · 2017 · Blood · DOI

Full title: Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor–modified T-cell therapy

Authors: Hay, Kevin A.; Hanafi, Laïla‐Aïcha; Li, Daniel; Gust, Juliane; Liles, W. Conrad; Wurfel, Mark M.; López, José A.; Chen, Junmei; Chung, Dominic W.; Harju-Baker, Susanna; Cherian, Sindhu; Chen, Xueyan; Riddell, Stanley R.; Maloney, David G.; Turtle, Cameron J.

Year: 2017

Venue: Blood

DOI: https://doi.org/10.1182/blood-2017-06-793141

Paper Preliminary Data on Safety, Cellular Kinetics and Anti-Leukemic Activity of UCART19, an Allogeneic Anti-CD19 CAR T-Cell Product, in a Pool of Adult and Pediatric Patients with High-Risk CD19+ Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia

R. Benjamin; Charlotte Graham; D. Yallop et al. · 2018 · Blood · DOI

Full title: Preliminary Data on Safety, Cellular Kinetics and Anti-Leukemic Activity of UCART19, an Allogeneic Anti-CD19 CAR T-Cell Product, in a Pool of Adult and Pediatric Patients with High-Risk CD19+ Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia

Authors: R. Benjamin; Charlotte Graham; D. Yallop; A. Jóźwik; O. Ciocârlie; N. Jain; E. Jabbour; M. Maus; M. Frigault; N. Boissel; J. Larghero; A. Baruchel; M. Mohty; B. Moerloose; A. Bloor; N. Frey; A. Zinai; S. Balandraud; Anne Philippe; Sylvain Fouliard; Ludiane Gauthier; J. Pauly; C. Konto; C. Bermingham; P. Veys; W. Qasim

Year: 2018

Venue: Blood

DOI: https://doi.org/10.1182/blood-2018-99-111356

Paper Improved Expansion and Function of CAR T Cell Products from Cultures Initiated at Defined CD4:CD8 Ratios

D. H. Lee; Francisco Cervantes-Contreras; S. Lee et al. · 2018 · Blood · DOI

Full title: Improved Expansion and Function of CAR T Cell Products from Cultures Initiated at Defined CD4:CD8 Ratios

Authors: D. H. Lee; Francisco Cervantes-Contreras; S. Lee; D. Green; B. Till

Year: 2018

Venue: Blood

DOI: https://doi.org/10.1182/blood-2018-99-111576

Paper Human Pluripotent Stem Cell-Derived Blood Cells for Therapies

D. Kaufman · 2018 · Blood · DOI

Full title: Human Pluripotent Stem Cell-Derived Blood Cells for Therapies

Authors: D. Kaufman

Year: 2018

Venue: Blood

DOI: https://doi.org/10.1182/blood-2018-99-109424

Paper Interleukin 21 Enhances Survival and Expansion of CAR T Cells Via Inhibition of Their Terminal Differentiation during Interaction with Tumor Target Cells

M. Štach; J. Musil; P. Cetkovský et al. · 2018 · Blood · DOI

Full title: Interleukin 21 Enhances Survival and Expansion of CAR T Cells Via Inhibition of Their Terminal Differentiation during Interaction with Tumor Target Cells

Authors: M. Štach; J. Musil; P. Cetkovský; P. Otáhal

Year: 2018

Venue: Blood

DOI: https://doi.org/10.1182/blood-2018-99-116294

Paper Early Clinical Experience of CD19 x CD22 Dual Specific CAR T Cells for Enhanced Anti-Leukemic Targeting of Acute Lymphoblastic Leukemia

R. Gardner; Colleen Annesley; O. Finney et al. · 2018 · Blood · DOI

Full title: Early Clinical Experience of CD19 x CD22 Dual Specific CAR T Cells for Enhanced Anti-Leukemic Targeting of Acute Lymphoblastic Leukemia

Authors: R. Gardner; Colleen Annesley; O. Finney; C. Summers; A. Lamble; Julie M Rivers; K. Crews; Lauren A Huang; Christopher Brown; Stephanie Mgebroff; C. Lindgren; K. Spratt; Joshua A Gustafson; Adam J. Johnson; Julie R. Park; M. Jensen

Year: 2018

Venue: Blood

DOI: https://doi.org/10.1182/blood-2018-99-113126

Paper Early Response Data for Pediatric Patients with Non-Hodgkin Lymphoma Treated with CD19 Chimeric Antigen Receptor (CAR) T-Cells

Julie M Rivers; Colleen Annesley; Colleen Annesley et al. · 2018 · Blood · DOI

Full title: Early Response Data for Pediatric Patients with Non-Hodgkin Lymphoma Treated with CD19 Chimeric Antigen Receptor (CAR) T-Cells

Authors: Julie M Rivers; Colleen Annesley; Colleen Annesley; C. Summers; C. Summers; O. Finney; M. Pulsipher; A. Wayne; Julie R. Park; Julie R. Park; M. Jensen; M. Jensen; R. Gardner; R. Gardner

Year: 2018

Venue: Blood

DOI: https://doi.org/10.1182/blood-2018-99-113744

Paper Automated Generation and Phenotypic Characterization of Clinical Grade CD19 CAR-T Cells

A. Sharma; A. Roe; Filipa B. Lopes et al. · 2018 · Blood · DOI

Full title: Automated Generation and Phenotypic Characterization of Clinical Grade CD19 CAR-T Cells

Authors: A. Sharma; A. Roe; Filipa B. Lopes; Ruifu Liu; J. Reese; S. Ribeiro; R. Sékaly; M. Lima; D. Wald

Year: 2018

Venue: Blood

DOI: https://doi.org/10.1182/blood-2018-99-120098

Paper Title Point-of-Care Production of CD19 CAR-T Cells in an Automated Closed-System: Report of First Clinical Experience

O. Molostova, L. Shelikhova, Yakov O. Muzalevsky, A. Kazachenok, D. Pershin, E. Kurnikova, A. Popov, B. Dropulić, Dina Shneider, R. Orentas, R. Alex, M. Essl, N. Miakova, D. Litvinov, A. Karachunskiy, G. Novichkova, A. Maschan, M. Maschan · 2018 · Blood · DOI

Full title: Title Point-of-Care Production of CD19 CAR-T Cells in an Automated Closed-System: Report of First Clinical Experience

Authors: O. Molostova, L. Shelikhova, Yakov O. Muzalevsky, A. Kazachenok, D. Pershin, E. Kurnikova, A. Popov, B. Dropulić, Dina Shneider, R. Orentas, R. Alex, M. Essl, N. Miakova, D. Litvinov, A. Karachunskiy, G. Novichkova, A. Maschan, M. Maschan

Year: 2018

Venue: Blood

DOI: https://doi.org/10.1182/blood-2018-99-118282

Paper Abbreviated T-Cell Activation on the Automated Clinimacs Prodigy Device Enhances Bispecific CD19/22 Chimeric Antigen Receptor T-Cell Viability and Fold Expansion, Reducing Total Culture Duration

S. Srivastava; S. Panch; J. Jin et al. · 2018 · Blood · DOI

Full title: Abbreviated T-Cell Activation on the Automated Clinimacs Prodigy Device Enhances Bispecific CD19/22 Chimeric Antigen Receptor T-Cell Viability and Fold Expansion, Reducing Total Culture Duration

Authors: S. Srivastava; S. Panch; J. Jin; Haneen Shalabi; N. Shah; S. Highfill; D. Stroncek

Year: 2018

Venue: Blood

DOI: https://doi.org/10.1182/blood-2018-99-116846

Paper Preemptive mitigation of CD19 CAR T-cell cytokine release syndrome without attenuation of antileukemic efficacy

Gardner, Rebecca; Ceppi, Francesco; Rivers, Julie et al. · 2019 · Blood · DOI

Full title: Preemptive mitigation of CD19 CAR T-cell cytokine release syndrome without attenuation of antileukemic efficacy

Authors: Gardner, Rebecca; Ceppi, Francesco; Rivers, Julie; Annesley, Colleen; Summers, Corinne; Taraseviciute, Agne; Gust, Juliane; Leger, Kasey J.; Tarlock, Katherine; Cooper, Todd M.; Finney, Olivia; Brakke, Hannah; Li, Daniel H.; Park, Julie R.; Jensen, Michael C.

Year: 2019

Venue: Blood

DOI: https://doi.org/10.1182/blood.2019001463

Paper ALLO-715, an Allogeneic BCMA CAR T Therapy Possessing an Off-Switch for the Treatment of Multiple Myeloma

C. Sommer; Bijan Boldajipour; J. Valton et al. · 2018 · Blood · DOI

Full title: ALLO-715, an Allogeneic BCMA CAR T Therapy Possessing an Off-Switch for the Treatment of Multiple Myeloma

Authors: C. Sommer; Bijan Boldajipour; J. Valton; R. Galetto; Trevor Bentley; Janette Sutton; Yajin Ni; M. Leonard; Thomas Van Blarcom; J. Smith; J. Chaparro-Riggers; B. Sasu

Year: 2018

Venue: Blood

DOI: https://doi.org/10.1182/blood-2018-99-119227

Paper Use of Multi-Omics Approach to Produce a Robust Serum-Free Media for the Expansion of T Cells

S. Mansour; Pei-Yi Lin; A. Pierce et al. · 2019 · Blood · DOI

Full title: Use of Multi-Omics Approach to Produce a Robust Serum-Free Media for the Expansion of T Cells

Authors: S. Mansour; Pei-Yi Lin; A. Pierce; C. Civin

Year: 2019

Venue: Blood

DOI: https://doi.org/10.1182/blood-2019-124393

Paper Predictors of T Cell Expansion and Clinical Responses Following B-Cell Maturation Antigen-Specific Chimeric Antigen Receptor T Cell Therapy (CART-BCMA) for Relapsed/Refractory Multiple Myeloma (MM)

A. Cohen; J. Melenhorst; A. Garfall et al. · 2018 · Blood · DOI

Full title: Predictors of T Cell Expansion and Clinical Responses Following B-Cell Maturation Antigen-Specific Chimeric Antigen Receptor T Cell Therapy (CART-BCMA) for Relapsed/Refractory Multiple Myeloma (MM)

Authors: A. Cohen; J. Melenhorst; A. Garfall; S. Lacey; M. Davis; D. Vogl; Lifeng Tian; V. Gonzalez; Iulian Pruteanu; A. Nelson; G. Plesa; A. Waxman; R. Young; B. Levine; C. June; E. Stadtmauer; M. Milone

Year: 2018

Venue: Blood

DOI: https://doi.org/10.1182/blood-2018-99-119665

Paper A Feasibility and Safety Study of a New CD19-Directed Fast CAR-T Therapy for Refractory and Relapsed B Cell Acute Lymphoblastic Leukemia

Jun-fang Yang; Jiaping He; Xian Zhang et al. · 2019 · Blood · DOI

Full title: A Feasibility and Safety Study of a New CD19-Directed Fast CAR-T Therapy for Refractory and Relapsed B Cell Acute Lymphoblastic Leukemia

Authors: Jun-fang Yang; Jiaping He; Xian Zhang; Zhenguang Wang; Yongliang Zhang; Songbai Cai; Zhe Sun; Xun Ye; Yan He; Lianjun Shen; Jiujiang He; Gailing Zhang; Dan Song; M. Zhang; Xiaona Hu; Jing-jing Li; S. Xia; Li Xu; W. Cao; P. Lu

Year: 2019

Venue: Blood

DOI: https://doi.org/10.1182/blood-2019-121751

Paper Enhancing Human NK Cell Function and Specificity for Cancer Immunotherapy

Emily, Pomeroy; John, Hunzeker; Mitchell, Kluesner et al. · 2018 · Blood · DOI

Full title: Enhancing Human NK Cell Function and Specificity for Cancer Immunotherapy

Authors: Emily, Pomeroy; John, Hunzeker; Mitchell, Kluesner; Margaret, Crosby; Bendzick, Laura E.; Miller, Jeffrey S.; Webber, Beau R.; Geller, Melissa A.; Felices, Martin; Starr, Timothy K.; Moriarity, Branden S.

Year: 2018

Venue: Blood

DOI: https://doi.org/10.1182/blood-2018-99-120173

Paper Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity

Fultang, Livingstone; Booth, Sarah; Yogev, Orli et al. · 2020 · Blood · DOI

Full title: Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity

Authors: Fultang, Livingstone; Booth, Sarah; Yogev, Orli; Costa, Barbara Martins Da; Tubb, Vanessa; Panetti, Silvia; Stavrou, Victoria; Scarpa, Ugo; Jankevics, Andris; Lloyd, Gavin R.; Southam, Andrew D.; Lee, Steven P.; Dunn, Warwick B.; Chesler, Louis; Mussai, Francis; Santo, Carmela De

Year: 2020

Venue: Blood

DOI: https://doi.org/10.1182/blood.2019004500

Paper FT596: Translation of First-of-Kind Multi-Antigen Targeted Off-the-Shelf CAR-NK Cell with Engineered Persistence for the Treatment of B Cell Malignancies

Jode Goodridge; S. Mahmood; Huang Zhu et al. · 2019 · Blood · DOI

Full title: FT596: Translation of First-of-Kind Multi-Antigen Targeted Off-the-Shelf CAR-NK Cell with Engineered Persistence for the Treatment of B Cell Malignancies

Authors: Jode Goodridge; S. Mahmood; Huang Zhu; S. Gaidarova; R. Blum; R. Bjordahl; Frank Cichocki; Hui-yi Chu; G. Bonello; Thomas K. Lee; B. Groff; M. Meza; B. Walcheck; Karl-Johan Malmberg; Jeffrey S. Miller; D. Kaufman; Bahram Valamehr

Year: 2019

Venue: Blood

DOI: https://doi.org/10.1182/blood-2019-129319

Paper Local Manufacture of CD19 CAR-T Cells Using an Automated Closed-System: Robust Manufacturing and High Clinical Efficacy with Low Toxicities

O. Molostova; L. Shelikhova; D. Schneider et al. · 2019 · Blood · DOI

Full title: Local Manufacture of CD19 CAR-T Cells Using an Automated Closed-System: Robust Manufacturing and High Clinical Efficacy with Low Toxicities

Authors: O. Molostova; L. Shelikhova; D. Schneider; R. Khismatullina; Yakov O. Muzalevsky; A. Kazachenok; Liane Preussner; G. Rauser; Julia Abugova; E. Kurnikova; D. Pershin; V. Zubachenko; A. Popov; O. Illarionova; N. Miakova; D. Litvinov; G. Novichkova; A. Maschan; R. Orentas; B. Dropulić; M. Maschan

Year: 2019

Venue: Blood

DOI: https://doi.org/10.1182/blood-2019-130370

Paper Preclinical Characterization of Prgn-3006 Ultracar-T™ for the Treatment of AML and MDS: Non-Viral, Multigenic Autologous CAR-T Cells Administered One Day after Gene Transfer

T. Chan; Xiaohong Ma; Fernando Carvajal-Borda et al. · 2019 · Blood · DOI

Full title: Preclinical Characterization of Prgn-3006 Ultracar-T™ for the Treatment of AML and MDS: Non-Viral, Multigenic Autologous CAR-T Cells Administered One Day after Gene Transfer

Authors: T. Chan; Xiaohong Ma; Fernando Carvajal-Borda; J. Vélez; Jacques Plummer; Lindsey Shepard; Rutul R. Shah; D. Sallman; H. Sabzevari

Year: 2019

Venue: Blood

DOI: https://doi.org/10.1182/blood-2019-130617

Paper Next Generation NKG2D-based CAR T-cells (CYAD-02): Co-expression of a Single shRNA Targeting MICA and MICB Improves Cell Persistence and Anti-Tumor Efficacy in vivo

M. Fontaine; B. Demoulin; S. Bornschein et al. · 2019 · Blood · DOI

Full title: Next Generation NKG2D-based CAR T-cells (CYAD-02): Co-expression of a Single shRNA Targeting MICA and MICB Improves Cell Persistence and Anti-Tumor Efficacy in vivo

Authors: M. Fontaine; B. Demoulin; S. Bornschein; S. Raitano; S. Lenger; H. Machado; Jonathan D. Moore; P. Sotiropoulou; D. Gilham

Year: 2019

Venue: Blood

DOI: https://doi.org/10.1182/blood-2019-129998

Paper Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates

Rust, Blake J.; Kean, Leslie S.; Colonna, Lucrezia et al. · 2020 · Blood · DOI

Full title: Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates

Authors: Rust, Blake J.; Kean, Leslie S.; Colonna, Lucrezia; Brandenstein, Katherine E.; Poole, Nikhita H.; Obenza, Willimark; Enstrom, Mark; Maldini, Colby R.; Ellis, Gavin I.; Fennessey, Christine M.; Huang, Meei‐Li; Keele, Brandon F.; Jerome, Keith R.; Riley, James L.; Kiem, Hans‐Peter; Peterson, Christopher W.

Year: 2020

Venue: Blood

DOI: https://doi.org/10.1182/blood.2020006372

Paper Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases

Chen, Yuehong; Sun, Jianhong; Liu, Huan et al. · 2019 · Journal of Immunology Research · DOI

Full title: Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases

Authors: Chen, Yuehong; Sun, Jianhong; Liu, Huan; Yin, Geng; Xie, Qibing

Year: 2019

Venue: Journal of Immunology Research

DOI: https://doi.org/10.1155/2019/5727516

Paper Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system.

Harjeet Singh; P. Manuri; S. Olivares et al. · 2008 · Cancer Research · DOI

Full title: Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system.

Authors: Harjeet Singh; P. Manuri; S. Olivares; N. Dara; Margaret J. Dawson; H. Huls; P. Hackett; D. Kohn; E. Shpall; R. Champlin; L. Cooper

Year: 2008

Venue: Cancer Research

DOI: https://doi.org/10.1158/0008-5472.can-07-5600

Paper Anti-GD3 Chimeric sFv-CD28/T-Cell Receptor ζ Designer T Cells for Treatment of Metastatic Melanoma and Other Neuroectodermal Tumors

Lo, Agnes S.; Ma, Qiangzhong; Liu, David L. et al. · 2010 · Clinical Cancer Research · DOI

Full title: Anti-GD3 Chimeric sFv-CD28/T-Cell Receptor ζ Designer T Cells for Treatment of Metastatic Melanoma and Other Neuroectodermal Tumors

Authors: Lo, Agnes S.; Ma, Qiangzhong; Liu, David L.; Junghans, Richard P.

Year: 2010

Venue: Clinical Cancer Research

DOI: https://doi.org/10.1158/1078-0432.ccr-10-0043

Paper Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients

Tina Sarén; Mohanraj Ramachandran; Gustav Gammelgård et al. · 2023 · Clinical Cancer Research · DOI

Full title: Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients

Authors: Tina Sarén; Mohanraj Ramachandran; Gustav Gammelgård; T. Lövgren; Claudio Mirabello; Åsa K. Björklund; K. Wikström; J. Hashemi; E. Freyhult; H. Ahlström; R. Amini; H. Hagberg; A. Loskog; G. Enblad; M. Essand

Year: 2023

Venue: Clinical Cancer Research

DOI: https://doi.org/10.1158/1078-0432.ccr-23-0178

Paper Abstract 960: Defined cell composition and precise control over JCAR017 dose enables identification of relationships between chimeric antigen receptor T cell product attributes, pharmacokinetics, and clinical endpoints in NHL

Ryan P. Larson; R. Lower; T. Devries et al. · 2018 · Clinical research · DOI

Full title: Abstract 960: Defined cell composition and precise control over JCAR017 dose enables identification of relationships between chimeric antigen receptor T cell product attributes, pharmacokinetics, and clinical endpoints in NHL

Authors: Ryan P. Larson; R. Lower; T. Devries; Yue Jiang; Ronald J. Hause; R. Getto; B. Christin; N. K. Yee; M. Bowen; C. Weber; Danielle Li; T. Albertson; Claire L. Sutherland; Christopher G. Ramsborg

Year: 2018

Venue: Clinical research

DOI: https://doi.org/10.1158/1538-7445.am2018-960

Paper How to Train Your T Cells: Overcoming Immune Dysfunction in Multiple Myeloma

Cohen, Adam D.; Raje, Noopur; Fowler, Jessica et al. · 2019 · Clinical Cancer Research · DOI

Full title: How to Train Your T Cells: Overcoming Immune Dysfunction in Multiple Myeloma

Authors: Cohen, Adam D.; Raje, Noopur; Fowler, Jessica; Mezzi, Khalid; Scott, Emma; Dhodapkar, Madhav V.

Year: 2019

Venue: Clinical Cancer Research

DOI: https://doi.org/10.1158/1078-0432.ccr-19-2111

Paper Clinical Pharmacology of Tisagenlecleucel in B-cell Acute Lymphoblastic Leukemia

K. Mueller; Edward R. Waldron; S. Grupp et al. · 2018 · Clinical Cancer Research · DOI

Full title: Clinical Pharmacology of Tisagenlecleucel in B-cell Acute Lymphoblastic Leukemia

Authors: K. Mueller; Edward R. Waldron; S. Grupp; J. Levine; T. Laetsch; M. Pulsipher; M. Boyer; K. August; J. Hamilton; R. Awasthi; A. Stein; D. Sickert; A. Chakraborty; B. Levine; C. June; L. Tomassian; Sweta S. Shah; M. Leung; T. Taran; P. Wood; S. Maude

Year: 2018

Venue: Clinical Cancer Research

DOI: https://doi.org/10.1158/1078-0432.ccr-18-0758

Paper Abstract CT131: A phase I study of adoptive immunotherapy for advanced ROR1+ malignancies with defined subsets of autologous T cells expressing a ROR1-specific chimeric antigen receptor (ROR1-CAR)

J. Specht; Sylvia M. Lee; C. Turtle et al. · 2018 · Clinical Trials · DOI

Full title: Abstract CT131: A phase I study of adoptive immunotherapy for advanced ROR1+ malignancies with defined subsets of autologous T cells expressing a ROR1-specific chimeric antigen receptor (ROR1-CAR)

Authors: J. Specht; Sylvia M. Lee; C. Turtle; C. Berger; Ashwini Baladrishnan; S. Srivastava; V. Voillet; Joshua R. Veatch; T. Gooley; Erin Mullane; Colette N. Chaney; C. Rader; R. Pierce; R. Gottardo; D. Maloney; S. Riddell

Year: 2018

Venue: Clinical Trials

DOI: https://doi.org/10.1158/1538-7445.am2018-ct131

Paper Abstract 2327: Same day transduction andin vivoexpansion of chimeric antigen receptors and synthetic driver constructs for adoptive cellular therapy

Frédéric Vigant; Jianfang Hu; L. Jadin et al. · 2019 · Immunology · DOI

Full title: Abstract 2327: Same day transduction andin vivoexpansion of chimeric antigen receptors and synthetic driver constructs for adoptive cellular therapy

Authors: Frédéric Vigant; Jianfang Hu; L. Jadin; B. Lopez; Tiffany Lam; Hiba Shaban; A. Kundu; T. Mayall; G. Schreiber; F. Haerizadeh; J. Onuffer; G. Frost

Year: 2019

Venue: Immunology

DOI: https://doi.org/10.1158/1538-7445.am2019-2327

Paper - **DOI:** 10.1158/1538-7445.am2019-lb-072 - **Authors:** Christopher N. Johnson, H. Senior, N. Jesuraj - **Year:** 2019 - **Journal:** Immunology

Christopher N. Johnson; H. Senior; N. Jesuraj · 2019 · Immunology · DOI

Full title: - **DOI:** 10.1158/1538-7445.am2019-lb-072 - **Authors:** Christopher N. Johnson, H. Senior, N. Jesuraj - **Year:** 2019 - **Journal:** Immunology

Authors: Christopher N. Johnson; H. Senior; N. Jesuraj

Year: 2019

Venue: Immunology

DOI: https://doi.org/10.1158/1538-7445.am2019-lb-072

Paper Abstract 3523: A high-throughput screening strategy for the identification of novel lymphoproliferative elements

L. Jadin; Hiba Shaban; A. Kundu et al. · 2019 · Molecular and Cellular Biology / Genetics · DOI

Full title: Abstract 3523: A high-throughput screening strategy for the identification of novel lymphoproliferative elements

Authors: L. Jadin; Hiba Shaban; A. Kundu; G. Schreiber; S. Willis; F. Haerizadeh; J. Onuffer; G. Frost

Year: 2019

Venue: Molecular and Cellular Biology / Genetics

DOI: https://doi.org/10.1158/1538-7445.am2019-3523

Paper Abstract CT118: CARPETS: A Phase I study of the safety and immune effects of an escalating dose of autologous GD2 chimeric antigen receptor-expressing peripheral blood T cells in patients with GD2-positive metastatic melanoma and refractory solid tumors

M. Brown; T. Gargett · 2019 · Clinical Trials · DOI

Full title: Abstract CT118: CARPETS: A Phase I study of the safety and immune effects of an escalating dose of autologous GD2 chimeric antigen receptor-expressing peripheral blood T cells in patients with GD2-positive metastatic melanoma and refractory solid tumors

Authors: M. Brown; T. Gargett

Year: 2019

Venue: Clinical Trials

DOI: https://doi.org/10.1158/1538-7445.am2019-ct118

Paper Abstract 3252:OrthoCARs: Engineered human IL-2/IL-2Rb orthogonal pairs selectively enhance CAR T cell anti-tumor efficacy and durability of response

P. Aspuria; M. Bauer; S. Vivona et al. · 2020 · Immunology · DOI

Full title: Abstract 3252:OrthoCARs: Engineered human IL-2/IL-2Rb orthogonal pairs selectively enhance CAR T cell anti-tumor efficacy and durability of response

Authors: P. Aspuria; M. Bauer; S. Vivona; S. Kauder; S. McCauley; Romina Riener; Rene De Waal Malefyte; Navneet Ratti; Deepti Rokkam; J. Emmerich; P. Lupardus; R. Kastelein; M. Oft

Year: 2020

Venue: Immunology

DOI: https://doi.org/10.1158/1538-7445.am2020-3252

Paper Abstract 6593: PRGN-3005 UltraCAR-T™: multigenic CAR-T cells generated using non-viral gene delivery and rapid manufacturing process for the treatment of ovarian cancer

T. Chan; M. Chakiath; Lindsey Shepard et al. · 2020 · Immunology · DOI

Full title: Abstract 6593: PRGN-3005 UltraCAR-T™: multigenic CAR-T cells generated using non-viral gene delivery and rapid manufacturing process for the treatment of ovarian cancer

Authors: T. Chan; M. Chakiath; Lindsey Shepard; Simon Metenou; Fernando Carvajal-Borda; J. Vélez; Adeline Govekung; Jacques Plummer; C. Poortman; Padma Kamineny; Xiaohong Ma; Rutul R. Shah; M. Disis; H. Sabzevari

Year: 2020

Venue: Immunology

DOI: https://doi.org/10.1158/1538-7445.am2020-6593

Paper Abstract 2821: Incorporation of intrinsic checkpoint blockade enhances functionality of multigenic autologous UltraCAR-T® cells manufactured using non-viral gene delivery and rapid manufacturing process

Tim Chan; Cheryl Bolinger; Sean Scott et al. · 2022 · Cancer Research · DOI

Full title: Abstract 2821: Incorporation of intrinsic checkpoint blockade enhances functionality of multigenic autologous UltraCAR-T® cells manufactured using non-viral gene delivery and rapid manufacturing process

Authors: Tim Chan; Cheryl Bolinger; Sean Scott; Mengyan Du; C. Poortman; Byron Koenitzer; Taranjit Athwal; Lindsey Shepard; R. D. Slone; Shourik Dutta; Steven Zilko; James M. Dunleavey; Giorgio Zenere; Jacques Plummer; B. Klocke; C. Zinser; Shamim Ahmad; D. Brough; Rutul R. Shah; H. Sabzevari

Year: 2022

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2022-2821

Paper Abstract 555: Allogeneic Natural Killer cells engineered to express HER2 CAR, Interleukin 15 and TGF beta dominant negative receptor effectively control HER2+ tumors

C. Richardson; F. Moore; Andres Alvarez et al. · 2022 · Cancer Research · DOI

Full title: Abstract 555: Allogeneic Natural Killer cells engineered to express HER2 CAR, Interleukin 15 and TGF beta dominant negative receptor effectively control HER2+ tumors

Authors: C. Richardson; F. Moore; Andres Alvarez; Alexia Barandiaran; Luke Barron; E. Choi; Tucker Ezell; Charlotte Franco; Bashar J. Hamza; Jennifer Johnson; Annie Khamhoung; Taeyoon Kyung; M. Marques; D. Picarella; J. Sewell; A. Storer; M. Walsh; Vipin K. Suri

Year: 2022

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2022-555

Paper - **DOI:** 10.1158/1538-7445.am2022-2849 - **Authors:** Jessica Walls, Y. Kam, N. Romero - **Year:** 2022 - **Journal:** Cancer Research

Jessica Walls; Y. Kam; N. Romero · 2022 · Cancer Research · DOI

Full title: - **DOI:** 10.1158/1538-7445.am2022-2849 - **Authors:** Jessica Walls, Y. Kam, N. Romero - **Year:** 2022 - **Journal:** Cancer Research

Authors: Jessica Walls; Y. Kam; N. Romero

Year: 2022

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2022-2849

Paper Abstract 1128: Lineage tracing of CAR T cells in patients with B cell malignancies

· 2023 · Cancer Research · DOI

Full title: Abstract 1128: Lineage tracing of CAR T cells in patients with B cell malignancies

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2023-1128

Paper Abstract 5609: Investigating the undifferentiated pleomorphic sarcoma microenvironment through cytokine profiles of primary tumor and immune infiltrates

Victoria S Coward; Jacky Chen; N. Gokgoz et al. · 2022 · Cancer Research · DOI

Full title: Abstract 5609: Investigating the undifferentiated pleomorphic sarcoma microenvironment through cytokine profiles of primary tumor and immune infiltrates

Authors: Victoria S Coward; Jacky Chen; N. Gokgoz; K. Tsoi; J. Wunder; I. Andrulis

Year: 2022

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2022-5609

Paper Abstract 3606: Lenalidomide switch control of CAR T-cell phenotype and function via degradable membrane-bound IL-7

M. Kann; Alexander Tepper; Harrison Silva et al. · 2022 · Cancer Research · DOI

Full title: Abstract 3606: Lenalidomide switch control of CAR T-cell phenotype and function via degradable membrane-bound IL-7

Authors: M. Kann; Alexander Tepper; Harrison Silva; Isabel C. Lane; Amanda A Bouffard; R. Larson; B. Ebert; M. Maus; Max Jan

Year: 2022

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2022-3606

Paper - **DOI:** 10.1158/1538-7445.am2023-1775 - **Authors:** V. Alonso-Camino - **Year:** 2023 - **Journal:** Cancer Research

V. Alonso-Camino · 2023 · Cancer Research · DOI

Full title: - **DOI:** 10.1158/1538-7445.am2023-1775 - **Authors:** V. Alonso-Camino - **Year:** 2023 - **Journal:** Cancer Research

Authors: V. Alonso-Camino

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2023-1775

Paper Abstract 4096: Assessing individual variability in efficacy and toxicity of autologous and allogeneic chimeric antigen receptor T-cell immunotherapy using a PBMC-humanized mouse model

Won-Bok Lee; D. Rose; Katelyn Burleigh et al. · 2023 · Cancer Research · DOI

Full title: Abstract 4096: Assessing individual variability in efficacy and toxicity of autologous and allogeneic chimeric antigen receptor T-cell immunotherapy using a PBMC-humanized mouse model

Authors: Won-Bok Lee; D. Rose; Katelyn Burleigh; Blair Armstrong; Heather H Gustafson; R. Gardner; J. Keck; Jiwon Yang

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2023-4096

Paper Abstract 2916: CAR-NK cells generated with CAR-RNA-LNP express high cytotoxic activity against tumor cells

V. Golubovskaya; Jinying Sun; J. Sienkiewicz et al. · 2023 · Cancer Research · DOI

Full title: Abstract 2916: CAR-NK cells generated with CAR-RNA-LNP express high cytotoxic activity against tumor cells

Authors: V. Golubovskaya; Jinying Sun; J. Sienkiewicz; Yanwei Huang; Hua Zhou; Gongping Deng; Hizkia Harto; Shirley Xu; Robert D. Berahovich; Lijun Wu

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2023-2916

Paper Abstract 1781: G9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered T cells against hepatocellular carcinoma

M. Lam; J. Reales-Calderón; Jin Rong Ow et al. · 2023 · Cancer Research · DOI

Full title: Abstract 1781: G9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered T cells against hepatocellular carcinoma

Authors: M. Lam; J. Reales-Calderón; Jin Rong Ow; J. Aw; D. Tan; Ragavi Vijayakumar; Erica Ceccarello; Tommaso Tabaglio; Y. Lim; Wang Loo Chien; F. Lai; A. Tanoto; Qingfeng Chen; Radoslaw M. Sobota; Giulia Adriani; A. Bertoletti; E. Guccione; A. Pavesi

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2023-1781

Paper Abstract CT522: Feasibility and safety of a novel CD19 CAR T cell therapy in adults with R/R B-NHL

M. Kamdar; Cherilee Adams; S. Bair et al. · 2022 · Cancer Research · DOI

Full title: Abstract CT522: Feasibility and safety of a novel CD19 CAR T cell therapy in adults with R/R B-NHL

Authors: M. Kamdar; Cherilee Adams; S. Bair; B. Dropulić; Jonathon Gutman; B. Haverkos; Kimberly R. Jordan; R. Mallo; R. Marians; F. Mast; Lindsey R. Murphy; A. Roth; Matthew Seefeldt; A. Worden; M. Kadan; Ying Xiong; D. Schneider; R. Orentas; Terry J. Fry; M. Verneris

Year: 2022

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2022-ct522

Paper Abstract 4087: Co-expression of membrane bound IL-15 enhanced anti-tumor response of CAR-T

Cuiqing Yang; Fuwei Jiang; Y. Wang et al. · 2023 · Cancer Research · DOI

Full title: Abstract 4087: Co-expression of membrane bound IL-15 enhanced anti-tumor response of CAR-T

Authors: Cuiqing Yang; Fuwei Jiang; Y. Wang; Tingting Liu; Chao Wang; Qingyang Wang; Qin Wang; Gang Ye; R. Tang; Zhuoxiao Cao

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2023-4087

Paper Abstract CT122: A phase 1/2 open-label, multicenter, dose escalation and expansion study of AVB-001, an intraperitoneally administered, cell-generated, human IL-2 immunotherapy in patients with platinum-resistant, high-grade, serous adenocarcinoma of the ovary, primary peritoneum, or fallopian tube

S. Westin; T. Sims; K. Andreas et al. · 2023 · Cancer Research · DOI

Full title: Abstract CT122: A phase 1/2 open-label, multicenter, dose escalation and expansion study of AVB-001, an intraperitoneally administered, cell-generated, human IL-2 immunotherapy in patients with platinum-resistant, high-grade, serous adenocarcinoma of the ovary, primary peritoneum, or fallopian tube

Authors: S. Westin; T. Sims; K. Andreas; Eric Soliman; Manish Jain; C. D. Ullmann; A. Jazaeri

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2023-ct122

Paper Abstract 4108: Transient epigenetic reprogramming enhances T-cell proliferation and tumor clearance

Alec McQuiston; Junbao Yang; Jason M. Romero et al. · 2023 · Cancer Research · DOI

Full title: Abstract 4108: Transient epigenetic reprogramming enhances T-cell proliferation and tumor clearance

Authors: Alec McQuiston; Junbao Yang; Jason M. Romero; Naveen Bojjireddy; Travis J McQuiston; V. Sebastiano; Mustafa Turkoz

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2023-4108

Paper Abstract 35: In situ CAR T cell engineering using lipid nanoparticles for B cell lymphoma therapy

Nisi Zhang; Elise Robinson; Angelie Rivera-Rodriguez et al. · 2024 · Cancer Research · DOI

Full title: Abstract 35: In situ CAR T cell engineering using lipid nanoparticles for B cell lymphoma therapy

Authors: Nisi Zhang; Elise Robinson; Angelie Rivera-Rodriguez; James Wang; Yutong Guo; Bo Wu; Spencer K. Tumbale; M. Raie; M. Inayathullah; D. Czerwinski; Ronald Levy; Katherine W. Ferrara

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2024-35

Paper Abstract 5254: The “off-the-shelf ”CD19-CAR-Vδ1T cells demonstrated an enhanced therapeutic effect on B-cell malignancy models

Dan Chen; F. You; Cheng Chen et al. · 2024 · Cancer Research · DOI

Full title: Abstract 5254: The “off-the-shelf ”CD19-CAR-Vδ1T cells demonstrated an enhanced therapeutic effect on B-cell malignancy models

Authors: Dan Chen; F. You; Cheng Chen; Shufen Xiang; Ping Zhang; Hai Wu; Zhong Zheng; Min Wang; Xingbing Wang; Huimin Meng; Nan Yang; Bozhen Zhang; Lingyun Yang

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2024-5254

Paper - **DOI:** 10.1158/1538-7445.am2024-5252 - **Authors:** Vanesa Alonso-Camino, William Mirsch - **Year:** 2024 - **Journal:** Cancer Research

Vanesa Alonso-Camino; William Mirsch · 2024 · Cancer Research · DOI

Full title: - **DOI:** 10.1158/1538-7445.am2024-5252 - **Authors:** Vanesa Alonso-Camino, William Mirsch - **Year:** 2024 - **Journal:** Cancer Research

Authors: Vanesa Alonso-Camino; William Mirsch

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2024-5252

Paper Abstract 6325: Lineage tracing defines responding CAR T cells in patients with B cell malignancies

Zinaida Good; M. Hamilton; J. Spiegel et al. · 2024 · Cancer Research · DOI

Full title: Abstract 6325: Lineage tracing defines responding CAR T cells in patients with B cell malignancies

Authors: Zinaida Good; M. Hamilton; J. Spiegel; Moksha H Desai; Zachary J Ehlinger; Patrick Quinn; Yiyun Chen; Snehit Prabhu; Shin-Heng Chiou; Sreevidya Kurra; Eric Yang; Michael Ozawa; M. Frank; Lori S. Muffly; Gursharan K. Claire; S. Bharadwaj; Saurabh Dahiya; Katherine A. Kong; Mark M. Davis; Sylvia K. Plevritis; E. Sotillo; B. Sahaf; David B. Miklos; Crystal L. Mackall

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2024-6325

Paper Abstract 6121: A novel allogeneic anti-DLL3 CAR-NK cell therapy in treating small cell lung cancer

Chao Wang; Tingting Liu; Qin Wang et al. · 2025 · Cancer Research · DOI

Full title: Abstract 6121: A novel allogeneic anti-DLL3 CAR-NK cell therapy in treating small cell lung cancer

Authors: Chao Wang; Tingting Liu; Qin Wang; Yanxue Gong; Ling Chen; Fanxiang Gao; Fen Zhou; Zhuoxiao Cao

Year: 2025

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2025-6121

Paper Abstract 6328: Preclinical development of CAR T cells with antigen-inducible IL-18 enforcement to treat GD2-positive solid cancers

Lena Fischer-Riepe; S. Kailayangiri; Katharina Zimmermann et al. · 2024 · Cancer Research · DOI

Full title: Abstract 6328: Preclinical development of CAR T cells with antigen-inducible IL-18 enforcement to treat GD2-positive solid cancers

Authors: Lena Fischer-Riepe; S. Kailayangiri; Katharina Zimmermann; Rita Pfeifer; M. Aigner; B. Altvater; S. Kretschmann; Simon Voelkl; J. Hartley; Celine Dreger; Katja Petry; A. Bosio; Angelika von Doellen; Wolfgang Hartmann; Holger N. Lode; Dennis Goerlich; A. Mackensen; M. Jungblut; Axel Schambach; Hinrich Abken; C. Rossig

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2024-6328

Paper Abstract LB074: Preclinical development of API-192: An engineered CAR-NKT allogeneic cell therapy targeting CD19 and CD20 for the treatment of B-cell malignancies

Lanny Gov; Jiaji Yu; Maha Qubain et al. · 2024 · Cancer Research · DOI

Full title: Abstract LB074: Preclinical development of API-192: An engineered CAR-NKT allogeneic cell therapy targeting CD19 and CD20 for the treatment of B-cell malignancies

Authors: Lanny Gov; Jiaji Yu; Maha Qubain; Saige L. Pompura; Sean D. Allen; Michael A. Christopher; Jeff Wiezorek

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2024-lb074

Paper Abstract 4808: Physiological manufacturing conditions enhance in vivo efficacy of CD19 CAR T cells in mice

A. Zaitouna; Candy Garcia; L. Kucharczyk et al. · 2025 · Cancer Research · DOI

Full title: Abstract 4808: Physiological manufacturing conditions enhance in vivo efficacy of CD19 CAR T cells in mice

Authors: A. Zaitouna; Candy Garcia; L. Kucharczyk; Michael Steffey; Abriel Czachorowski; Natalie Czeryba; Ningchun Liu; S. Barnes; Y. Bronevetsky; Shannon Eaker; James Lim; Scott Wise

Year: 2025

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2025-4808

Paper Abstract 6311: From bench to bedside: GMP manufacturing and testing of an LGR5-targeting CAR-T against colorectal cancer

Veronika Bandara; Batjargal Gundsambuu; Silvana Napoli et al. · 2024 · Cancer Research · DOI

Full title: Abstract 6311: From bench to bedside: GMP manufacturing and testing of an LGR5-targeting CAR-T against colorectal cancer

Authors: Veronika Bandara; Batjargal Gundsambuu; Silvana Napoli; Jade Foeng; Dylan McPeake; Timona Tylis; Emma Thompson; Stuart J Mills; Allison Cowin; Claudine Bonder; Timothy J Sadlon; Shaun McColl; Simon C Barry

Year: 2024

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2024-6311

Paper Abstract IA019: Tumor microenvironment modulation is critical for cellular immunotherapy efficacy

T. Dorff; M. S. Blanchard; J. Murad et al. · 2023 · Cancer Research · DOI

Full title: Abstract IA019: Tumor microenvironment modulation is critical for cellular immunotherapy efficacy

Authors: T. Dorff; M. S. Blanchard; J. Murad; Lauren N. Adkins; Gaurav Dhaploa; S. Forman; S. Priceman

Year: 2023

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.prca2023-ia019

Paper Abstract 7265: Using PBMC-humanized mice to identify optimal autologous CAR T products for maximized efficacy and minimized toxicity at an individual level: a study of CD19, CD22, and CD19x22-specific constructs in multiple PBMC donors

Won-Bok Lee; Destanie Rose; Beau Parry et al. · 2025 · Cancer Research · DOI

Full title: Abstract 7265: Using PBMC-humanized mice to identify optimal autologous CAR T products for maximized efficacy and minimized toxicity at an individual level: a study of CD19, CD22, and CD19x22-specific constructs in multiple PBMC donors

Authors: Won-Bok Lee; Destanie Rose; Beau Parry; Joshua A. Gustafson; Rebecca Gardner; Heather H Gustafson; James G. Keck; Jiwon Yang

Year: 2025

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2025-7265

Paper Naïve T-cell Deficits at Diagnosis and after Chemotherapy Impair Cell Therapy Potential in Pediatric Cancers.

R. Das; Lauren M. Vernau; S. Grupp et al. · 2019 · Cancer Discovery · DOI

Full title: Naïve T-cell Deficits at Diagnosis and after Chemotherapy Impair Cell Therapy Potential in Pediatric Cancers.

Authors: R. Das; Lauren M. Vernau; S. Grupp; D. Barrett

Year: 2019

Venue: Cancer Discovery

DOI: https://doi.org/10.1158/2159-8290.cd-18-1314

Paper - **DOI:** 10.1158/1538-7445.sabcs18-1209 - **Authors:** Zhaoping Liu, Andrea Donart-Gomez, John O’Rourke - **Year:** 2019 - **Journal:** Experimental and Molecular Therapeutics

Zhaoping Liu; Andrea Donart-Gomez; John O’Rourke · 2019 · Experimental and Molecular Therapeutics · DOI

Full title: - **DOI:** 10.1158/1538-7445.sabcs18-1209 - **Authors:** Zhaoping Liu, Andrea Donart-Gomez, John O’Rourke - **Year:** 2019 - **Journal:** Experimental and Molecular Therapeutics

Authors: Zhaoping Liu; Andrea Donart-Gomez; John O’Rourke

Year: 2019

Venue: Experimental and Molecular Therapeutics

DOI: https://doi.org/10.1158/1538-7445.sabcs18-1209

Paper Abstract P2-09-13: A phase I study of adoptive immunotherapy for ROR1+ advanced triple negative breast cancer (TNBC) with defined subsets of autologous T cells expressing a ROR1-specific chimeric antigen receptor (ROR1-CAR)

J. Specht; Sylvia M. Lee; C. Turtle et al. · 2019 · Poster Session Abstracts · DOI

Full title: Abstract P2-09-13: A phase I study of adoptive immunotherapy for ROR1+ advanced triple negative breast cancer (TNBC) with defined subsets of autologous T cells expressing a ROR1-specific chimeric antigen receptor (ROR1-CAR)

Authors: J. Specht; Sylvia M. Lee; C. Turtle; C. Berger; Ashwini Balakrishnan; S. Srivastava; V. Viollet; Joshua R. Veatch; T. Gooley; Erin Mullane; Colette N. Chaney; C. Rader; R. Pierce; R. Gottardo; D. Maloney; S. Riddell

Year: 2019

Venue: Poster Session Abstracts

DOI: https://doi.org/10.1158/1538-7445.sabcs18-p2-09-13

Paper Outlook for New CAR-Based Therapies with a Focus on CAR NK Cells: What Lies Beyond CAR-Engineered T Cells in the Race against Cancer

Daher, May; Rezvani, Katayoun · 2020 · Cancer Discovery · DOI

Full title: Outlook for New CAR-Based Therapies with a Focus on CAR NK Cells: What Lies Beyond CAR-Engineered T Cells in the Race against Cancer

Authors: Daher, May; Rezvani, Katayoun

Year: 2020

Venue: Cancer Discovery

DOI: https://doi.org/10.1158/2159-8290.cd-20-0556

Paper Glypican-3–Specific CAR T Cells Coexpressing IL15 and IL21 Have Superior Expansion and Antitumor Activity against Hepatocellular Carcinoma

S. Batra; Purva Rathi; Linjie Guo et al. · 2020 · Cancer immunology research · DOI

Full title: Glypican-3–Specific CAR T Cells Coexpressing IL15 and IL21 Have Superior Expansion and Antitumor Activity against Hepatocellular Carcinoma

Authors: S. Batra; Purva Rathi; Linjie Guo; Amy N. Courtney; Julien Fleurence; Julien Balzeau; R. Shaik; T. Nguyen; Meng-fen Wu; Shaun Bulsara; Maksim Mamonkin; L. Metelitsa; A. Heczey

Year: 2020

Venue: Cancer immunology research

DOI: https://doi.org/10.1158/2326-6066.cir-19-0293

Paper Superkine IL-2 and IL-33 Armored CAR T Cells Reshape the Tumor Microenvironment and Reduce Growth of Multiple Solid Tumors

Brog, Rachel A.; Ferry, Shannon L.; Schiebout, Courtney et al. · 2022 · Cancer Immunology Research · DOI

Full title: Superkine IL-2 and IL-33 Armored CAR T Cells Reshape the Tumor Microenvironment and Reduce Growth of Multiple Solid Tumors

Authors: Brog, Rachel A.; Ferry, Shannon L.; Schiebout, Courtney; Messier, Cameron; Cook, W. James; Abdullah, Leena; Zou, Jia; Kumar, Prathna; Sentman, Charles L.; Frost, H. Robert; Huang, Yina H.

Year: 2022

Venue: Cancer Immunology Research

DOI: https://doi.org/10.1158/2326-6066.cir-21-0536

Paper Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells

Frigault, Matthew J.; Lee, Ji‐Hyun; Basil, Maria C. et al. · 2015 · Cancer Immunology Research · DOI

Full title: Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells

Authors: Frigault, Matthew J.; Lee, Ji‐Hyun; Basil, Maria C.; Carpenito, Carmine; Motohashi, Shinichiro; Scholler, John; Kawalekar, Omkar U.; Guedan, Sònia; McGettigan, Shannon E.; Posey, Avery D.; Ang, Sonny; Cooper, Laurence J.N.; Platt, Jesse M.; Johnson, F. Brad; Paulos, Chrystal M.; Zhao, Yangbing; Kalos, Michael; Milone, Michael C.; June, Carl H.

Year: 2015

Venue: Cancer Immunology Research

DOI: https://doi.org/10.1158/2326-6066.cir-14-0186

Paper Engineered T-cell Receptor T Cells for Cancer Immunotherapy

U. Greenbaum; E. E. Dumbrava; A. Biter et al. · 2021 · Cancer immunology research · DOI

Full title: Engineered T-cell Receptor T Cells for Cancer Immunotherapy

Authors: U. Greenbaum; E. E. Dumbrava; A. Biter; C. Haymaker; D. Hong

Year: 2021

Venue: Cancer immunology research

DOI: https://doi.org/10.1158/2326-6066.cir-21-0269

Paper FOXO1 inhibition generates potent non-activated CAR T cells against solid tumors.

Maude Marchais; Luca Simula; Melanie Phayanouvong et al. · 2023 · Cancer immunology research · DOI

Full title: FOXO1 inhibition generates potent non-activated CAR T cells against solid tumors.

Authors: Maude Marchais; Luca Simula; Melanie Phayanouvong; F. Mami-Chouaib; G. Bismuth; J. Decroocq; D. Bouscary; J. Dutrieux; M. Mangeney

Year: 2023

Venue: Cancer immunology research

DOI: https://doi.org/10.1158/2326-6066.cir-22-0533

Paper Phase I Trial of Autologous CAR T Cells Targeting NKG2D Ligands in Patients with AML/MDS and Multiple Myeloma

Susanne H. Baumeister; Joana M. Murad; L. Werner et al. · 2018 · Cancer immunology research · DOI

Full title: Phase I Trial of Autologous CAR T Cells Targeting NKG2D Ligands in Patients with AML/MDS and Multiple Myeloma

Authors: Susanne H. Baumeister; Joana M. Murad; L. Werner; H. Daley; H. Trébéden‐Nègre; Joanina K. Gicobi; Adam C Schmucker; J. Reder; C. Sentman; D. Gilham; F. Lehmann; I. Galinsky; Heidi Dipietro; Kristen Cummings; N. Munshi; R. Stone; D. Neuberg; R. Soiffer; G. Dranoff; J. Ritz; S. Nikiforow

Year: 2018

Venue: Cancer immunology research

DOI: https://doi.org/10.1158/2326-6066.cir-18-0307

Paper Enhancing CAR T-cell Therapy Using Fab-Based Constitutively Heterodimeric Cytokine Receptors.

Righi, Matteo; Gannon, Isaac; Robson, Matthew et al. · 2023 · Cancer immunology research · DOI

Full title: Enhancing CAR T-cell Therapy Using Fab-Based Constitutively Heterodimeric Cytokine Receptors.

Authors: Righi, Matteo; Gannon, Isaac; Robson, Matthew; Srivastava, Saket; Kokalaki, Evangelia; Grothier, Thomas; Nannini, Francesco; Allen, Christopher; Bai, Yuchen V; Sillibourne, James; Cordoba, Shaun; Thomas, Simon; Pule, Martin

Year: 2023

Venue: Cancer immunology research

DOI: https://doi.org/10.1158/2326-6066.CIR-22-0640

Paper A Novel Autologous CAR-T Therapy, YTB323, with Preserved T-cell Stemness Shows Enhanced CAR T-cell Efficacy in Preclinical and Early Clinical Development

Dickinson, Michael; Barba, Pere; Jäger, Ulrich et al. · 2023 · Cancer Discovery · DOI

Full title: A Novel Autologous CAR-T Therapy, YTB323, with Preserved T-cell Stemness Shows Enhanced CAR T-cell Efficacy in Preclinical and Early Clinical Development

Authors: Dickinson, Michael; Barba, Pere; Jäger, Ulrich; Shah, Nirav N.; Blaise, Didier; Briones, Javier; Shune, Leyla; Boissel, Nicolas; Bondanza, Attilio; Mariconti, Luisa; Marchal, Anne-Laure; Quinn, David S.; Yang, Jennifer; Price, Andrew; Sohoni, Akash; Treanor, Louise M.; Orlando, Elena J.; Mataraza, Jennifer; Davis, Jaclyn; Lu, Darlene; Zhu, Xu; Engels, Boris; Parseval, Laure Moutouh–de; Brogdon, Jennifer L.; Moschetta, Michele; Flinn, Ian W.

Year: 2023

Venue: Cancer Discovery

DOI: https://doi.org/10.1158/2159-8290.cd-22-1276

Paper Abstract A025: Eradication of neuroblastoma by T-cells redirected with an optimized GD2-specific chimeric antigen receptor and IL-15

Chen, Yu‐Hui; Sun, Chuang; Metelitsa, Leonid S. et al. · 2019 · Cancer Immunology Research · DOI

Full title: Abstract A025: Eradication of neuroblastoma by T-cells redirected with an optimized GD2-specific chimeric antigen receptor and IL-15

Authors: Chen, Yu‐Hui; Sun, Chuang; Metelitsa, Leonid S.; Dotti, Gianpietro; Savoldo, Barbara

Year: 2019

Venue: Cancer Immunology Research

DOI: https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a025

Paper Abstract B009: Developing a platform for CEA-directed CAR-NK cells expressing IL-15 and CCL21 for the treatment of non-small cell lung cancer

Austin K. Rennels; Ji-Ann Lee; J. Abascal et al. · 2025 · Cancer immunology research · DOI

Full title: Abstract B009: Developing a platform for CEA-directed CAR-NK cells expressing IL-15 and CCL21 for the treatment of non-small cell lung cancer

Authors: Austin K. Rennels; Ji-Ann Lee; J. Abascal; William P Crosson; Faith Kim; M. Oh; B. Kahangi; E. P. Reyes; Nalani Coleman; C. Dumitras; Carlos Bottero; Hong Jiang; K. Krysan; L. Tran; R. Salehi-Rad; Bin Liu; Steven M. Dubinett

Year: 2025

Venue: Cancer immunology research

DOI: https://doi.org/10.1158/2326-6074.io2025-b009

Paper Chimeric Antigen Receptor T Cell Manufacturing on an Automated Cell Processor.

R. Machietto; N. Giacobbe; Jessica Perazzelli et al. · 2023 · Journal of Visualized Experiments · DOI

Full title: Chimeric Antigen Receptor T Cell Manufacturing on an Automated Cell Processor.

Authors: R. Machietto; N. Giacobbe; Jessica Perazzelli; T. Hofmann; Allison Barz Leahy; S. Grupp; Yongping Wang; S. Kadauke

Year: 2023

Venue: Journal of Visualized Experiments

DOI: https://doi.org/10.3791/65488

Paper Abstract A043: Anti-CD19 CAR T-cells with a CRISPR/Cas9-mediated T-cell receptor knockout show high functionality in the absence of alloreactivity in vitro

D. Stenger; Tanja A. Stief; Theresa Käuferle et al. · 2019 · Genetically Engineered T-cells · DOI

Full title: Abstract A043: Anti-CD19 CAR T-cells with a CRISPR/Cas9-mediated T-cell receptor knockout show high functionality in the absence of alloreactivity in vitro

Authors: D. Stenger; Tanja A. Stief; Theresa Käuferle; Semjon Willier; F. Rataj; Kilian Schober; R. Lotfi; Beate Wagner; D. Busch; S. Kobold; Franziska Blaeschke; T. Feuchtinger

Year: 2019

Venue: Genetically Engineered T-cells

DOI: https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a043

Paper Colorectal cancer and immunity: What we know and perspectives

Pernot, Simon · 2014 · World Journal of Gastroenterology · DOI

Full title: Colorectal cancer and immunity: What we know and perspectives

Authors: Pernot, Simon

Year: 2014

Venue: World Journal of Gastroenterology

DOI: https://doi.org/10.3748/wjg.v20.i14.3738

Paper IL-2: The First Effective Immunotherapy for Human Cancer

Rosenberg, Steven A. · 2014 · The Journal of Immunology · DOI

Full title: IL-2: The First Effective Immunotherapy for Human Cancer

Authors: Rosenberg, Steven A.

Year: 2014

Venue: The Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.1490019

Paper Using CRISPR/Cas9 to Knock Out GM-CSF in CAR-T Cells.

Rosalie M. Sterner; Michelle J. Cox; R. Sakemura et al. · 2019 · Journal of Visualized Experiments · DOI

Full title: Using CRISPR/Cas9 to Knock Out GM-CSF in CAR-T Cells.

Authors: Rosalie M. Sterner; Michelle J. Cox; R. Sakemura; S. Kenderian

Year: 2019

Venue: Journal of Visualized Experiments

DOI: https://doi.org/10.3791/59629

Paper Chimeric PD-1 receptor redirects primary T cells against childhood solid tumors but not to PD-1 ligand-positive CD80-coexpressing cells

Chansu Shin; Masaru Imamura; Yasushi Kasahara et al. · 2025 · Molecular Medicine Reports · DOI

Full title: Chimeric PD-1 receptor redirects primary T cells against childhood solid tumors but not to PD-1 ligand-positive CD80-coexpressing cells

Authors: Chansu Shin; Masaru Imamura; Yasushi Kasahara; Yuko Suzuki; Minori Baba; Nobuhiro Kubo; Ryosuke Hosokai; Haruko Iwabuchi; Yudai Murayama; Hiroyuki Kawashima; Akira Ogose; Keichiro Mihara; Akihiko Saitoh; C. Imai

Year: 2025

Venue: Molecular Medicine Reports

DOI: https://doi.org/10.3892/mmr.2025.13608

Paper The Impact of Various Cellular Product Characteristics on the Efficacy of Anti-CD19 Therapy with T-Lymphocytes Modified with Chimeric Antigen Receptor

A. I. Serdyuk; N. Ivanova; O. Aleshina et al. · 2025 · Russian journal of hematology and transfusiology · DOI

Full title: The Impact of Various Cellular Product Characteristics on the Efficacy of Anti-CD19 Therapy with T-Lymphocytes Modified with Chimeric Antigen Receptor

Authors: A. I. Serdyuk; N. Ivanova; O. Aleshina; D. V. Dianov; V. S. Kuznetsova; A. Mohammad; A. Bogolyubova

Year: 2025

Venue: Russian journal of hematology and transfusiology

DOI: https://doi.org/10.35754/0234-5730-2025-70-2-208-228

Paper Generation of Knock-out Primary and Expanded Human NK Cells Using Cas9 Ribonucleoproteins

Kararoudi, Meisam Naeimi; Dolatshad, Hamid; Trikha, Prashant et al. · 2018 · Journal of Visualized Experiments · DOI

Full title: Generation of Knock-out Primary and Expanded Human NK Cells Using Cas9 Ribonucleoproteins

Authors: Kararoudi, Meisam Naeimi; Dolatshad, Hamid; Trikha, Prashant; Hussain, Syed-Rehan A.; Elmas, Ezgi; Foltz, Jennifer A.; Moseman, Jena E.; Thakkar, Aarohi; Nakkula, Robin J.; Lamb, Margaret; Chakravarti, Nitin; McLaughlin, K. John; Lee, Dean A.

Year: 2018

Venue: Journal of Visualized Experiments

DOI: https://doi.org/10.3791/58237

Paper Optimization of human T cell activation and expansion protocols improves efficiency of genetic modification and overall cell yield

Jessie Yu; Priscilla Chen; Ashley Watson et al. · 2019 · Journal of Immunology · DOI

Full title: Optimization of human T cell activation and expansion protocols improves efficiency of genetic modification and overall cell yield

Authors: Jessie Yu; Priscilla Chen; Ashley Watson; Danielle Truong; J. Antonchuk; A. Kokaji; S. Woodside; A. Eaves; T. Thomas

Year: 2019

Venue: Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.202.supp.71.3

Paper Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody–Activated Chimeric Antigen Receptor–Modified T Cells

Michael Schmueck-Henneresse; Bilal Omer; T. Shum et al. · 2017 · Journal of Immunology · DOI

Full title: Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody–Activated Chimeric Antigen Receptor–Modified T Cells

Authors: Michael Schmueck-Henneresse; Bilal Omer; T. Shum; Haruko Tashiro; Maksim Mamonkin; N. Lapteva; Sandhya Sharma; L. Rollins; G. Dotti; P. Reinke; H. Volk; C. Rooney

Year: 2017

Venue: Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.1601494

Paper Low intensity vibration increases proliferation in human primary T cells: a non-invasive strategy to reduce “vein-to-vein” time in autologous cell therapies

C. Ashdown; M. Chan; C. Rubin · 2023 · Journal of Immunology · DOI

Full title: Low intensity vibration increases proliferation in human primary T cells: a non-invasive strategy to reduce “vein-to-vein” time in autologous cell therapies

Authors: C. Ashdown; M. Chan; C. Rubin

Year: 2023

Venue: Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.210.supp.68.02

Paper T Cell Activators Exhibit Distinct Downstream Effects on Chimeric Antigen Receptor T Cell Phenotype and Function

Sarah Underwood; Jianjian Jin; L. Shao et al. · 2024 · ImmunoHorizons · DOI

Full title: T Cell Activators Exhibit Distinct Downstream Effects on Chimeric Antigen Receptor T Cell Phenotype and Function

Authors: Sarah Underwood; Jianjian Jin; L. Shao; M. Procházková; Rongye Shi; Hannah W Song; Ping Jin; Nirali N. Shah; R. Somerville; David F. Stroncek; S. Highfill

Year: 2024

Venue: ImmunoHorizons

DOI: https://doi.org/10.4049/immunohorizons.2400008

Paper Precise control of immune modulation using DNA scaffold-mediated biomaterial functionalization

Xiao Huang; Q. Tang; W. Lim et al. · 2021 · Journal of Immunology · DOI

Full title: Precise control of immune modulation using DNA scaffold-mediated biomaterial functionalization

Authors: Xiao Huang; Q. Tang; W. Lim; T. Desai

Year: 2021

Venue: Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.206.supp.26.01

Paper Current Anti-Myeloma Chimeric Antigen Receptor-T Cells: Novel Targets and Methods

Ece Vural; M. Beksaç · 2025 · Balkan Medical Journal · DOI

Full title: Current Anti-Myeloma Chimeric Antigen Receptor-T Cells: Novel Targets and Methods

Authors: Ece Vural; M. Beksaç

Year: 2025

Venue: Balkan Medical Journal

DOI: https://doi.org/10.4274/balkanmedj.galenos.2025.2025-4-25

Paper Postprandial changes to systemic metabolism imprint durable changes on T cell immune responses

Alok Kumar; Dayana Rivadienera; Greg M. Delgoffe et al. · 2024 · Journal of Immunology · DOI

Full title: Postprandial changes to systemic metabolism imprint durable changes on T cell immune responses

Authors: Alok Kumar; Dayana Rivadienera; Greg M. Delgoffe; Amanda C. Poholek; Alison Kohan

Year: 2024

Venue: Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.212.supp.1397.4724

Paper CD137 (4-1BB) Engagement Fine-Tunes Synergistic IL-15– and IL-21–Driven NK Cell Proliferation

Vidard, Laurent; Dureuil, Christine; Baudhuin, Jérémy et al. · 2019 · The Journal of Immunology · DOI

Full title: CD137 (4-1BB) Engagement Fine-Tunes Synergistic IL-15– and IL-21–Driven NK Cell Proliferation

Authors: Vidard, Laurent; Dureuil, Christine; Baudhuin, Jérémy; Vescovi, Lionel; Durand, Laurence; Sierra, Véronique; Parmantier, Eric

Year: 2019

Venue: The Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.1801137

Paper T cell functional phenotyping on a single cell scale using hydrogel microparticles.

M. Kizerwetter; Do-Hyeoung Koo; D. Di Carlo et al. · 2023 · Journal of Immunology · DOI

Full title: T cell functional phenotyping on a single cell scale using hydrogel microparticles.

Authors: M. Kizerwetter; Do-Hyeoung Koo; D. Di Carlo; Jamie B. Spangler

Year: 2023

Venue: Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.210.supp.250.14

Paper Revolutionary Selection, Activation, and Expansion with Microbubbles for CAR-T Cell Manufacturing

Dominique Badea; Effie Huang; Tiffany Snow et al. · 2024 · Journal of Immunology · DOI

Full title: Revolutionary Selection, Activation, and Expansion with Microbubbles for CAR-T Cell Manufacturing

Authors: Dominique Badea; Effie Huang; Tiffany Snow; Jesse Chen; J. Roussey; Chia Ku; Casey Wegner

Year: 2024

Venue: Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.212.supp.0858.6575

Paper Novel Workflow for Activation and Expansion of T Cells Using Microbubble Technology

Jason S Ellis; C. Barrett; Tiffany Snow et al. · 2023 · Journal of Immunology · DOI

Full title: Novel Workflow for Activation and Expansion of T Cells Using Microbubble Technology

Authors: Jason S Ellis; C. Barrett; Tiffany Snow; J. Roussey; Maureen Carey; Chia Ku; Edward C Grimley; Casey Wegner; Brandon McNaughton

Year: 2023

Venue: Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.210.supp.249.16

Paper Chimeric Antigen Receptor Structure and Manufacturing of Clinical Grade CAR Engineered Cells using Different Bioreactors.

F. Syed; Riad El Fakih; A. Alahmari et al. · 2022 · Hematology/Oncology and Stem Cell Therapy · DOI

Full title: Chimeric Antigen Receptor Structure and Manufacturing of Clinical Grade CAR Engineered Cells using Different Bioreactors.

Authors: F. Syed; Riad El Fakih; A. Alahmari; Ahmed S Osman Ali; M. Aljurf

Year: 2022

Venue: Hematology/Oncology and Stem Cell Therapy

DOI: https://doi.org/10.56875/2589-0646.1048

Paper Optimization of methods for peripheral blood mononuclear cells isolation and expansion of human gamma delta T cells

M. Khan; A. A. Otaibi; S. Sherwani et al. · 2021 · Bioinformation · DOI

Full title: Optimization of methods for peripheral blood mononuclear cells isolation and expansion of human gamma delta T cells

Authors: M. Khan; A. A. Otaibi; S. Sherwani; E. M. Alshammari; S. Al‐Zahrani; W. Khan; Abdulmohsen K. D. Alsukaibi; Sultan Alouffi; S. Khan

Year: 2021

Venue: Bioinformation

DOI: https://doi.org/10.6026/97320630017460

Paper The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy

Lim, Aaron R.; Rathmell, W. Kimryn; Rathmell, Jeffrey C. · 2020 · eLife · DOI

Full title: The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy

Authors: Lim, Aaron R.; Rathmell, W. Kimryn; Rathmell, Jeffrey C.

Year: 2020

Venue: eLife

DOI: https://doi.org/10.7554/elife.55185

Paper Management of Immunotherapy-Related Toxicities, Version 1.2022, NCCN Clinical Practice Guidelines in Oncology

Thompson, John A.; Schneider, Bryan J.; Brahmer, Julie R. et al. · 2022 · Journal of the National Comprehensive Cancer Network · DOI

Full title: Management of Immunotherapy-Related Toxicities, Version 1.2022, NCCN Clinical Practice Guidelines in Oncology

Authors: Thompson, John A.; Schneider, Bryan J.; Brahmer, Julie R.; Achufusi, Amaka; Armand, Philippe; Berkenstock, Meghan; Bhatia, Shailender; Budde, Lihua E.; Chokshi, Saurin; Davies, Marianne; Elshoury, Amro; Gesthalter, Yaron; Hegde, Aparna; Jain, Michael D.; Kaffenberger, Benjamin H.; Lechner, Melissa G.; Li, Tianhong; Marr, Alissa; McGettigan, Suzanne; McPherson, Jordan P.; Medina, Theresa; Mohindra, Nisha; Olszanski, Anthony J.; Oluwole, Olalekan O.; Patel, Sandip Pravin; Patil, Pradnya D.; Reddy, Sunil; Ryder, Mabel; Santomasso, Bianca; Shofer, Scott; Sosman, Jeffrey A.; Wang, Yinghong; Zaha, Vlad G.; Lyons, Megan; Dwyer, Mary A.; Hang, Lisa

Year: 2022

Venue: Journal of the National Comprehensive Cancer Network

DOI: https://doi.org/10.6004/jnccn.2022.0020

Paper High-Content CD14+ Cells in Apheresis Products negatively affects the Transduction and Expansion of CAR T cells during Large-scale cGMP Manufacturing

I. Rivière; Jinrong Qu; J. Stefanski et al. · 2016 · Journal of Immunology · DOI

Full title: High-Content CD14+ Cells in Apheresis Products negatively affects the Transduction and Expansion of CAR T cells during Large-scale cGMP Manufacturing

Authors: I. Rivière; Jinrong Qu; J. Stefanski; Oriana Bórquez-Ojeda; A. Hack; Xiuyan Wang

Year: 2016

Venue: Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.196.supp.214.25

Paper Lymphokine-activated killer cell expansion for clinical trials of adoptive immunotherapy with interleukin-2: optimization of the culture technique.

M. Favrot; C. Coze; V. Combaret et al. · 1990 · Molecular biotherapy

Full title: Lymphokine-activated killer cell expansion for clinical trials of adoptive immunotherapy with interleukin-2: optimization of the culture technique.

Authors: M. Favrot; C. Coze; V. Combaret; M. Gaspard; C. Colin; C. Franks; S. Négrier; I. Philip; T. Philip

Year: 1990

Venue: Molecular biotherapy

Paper High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17+IL-10+ Memory CD4+ T Cell Response towards a Single IL-10–Producing Phenotype

E. Mann; L. Gabryšová; P. Pfeffer et al. · 2018 · Journal of Immunology · DOI

Full title: High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17+IL-10+ Memory CD4+ T Cell Response towards a Single IL-10–Producing Phenotype

Authors: E. Mann; L. Gabryšová; P. Pfeffer; A. O’Garra; C. Hawrylowicz

Year: 2018

Venue: Journal of Immunology

DOI: https://doi.org/10.4049/jimmunol.1800697

Paper Fueling chimeric antigen receptor T cells with cytokines.

Jin Jin; Jiali Cheng; Meijuan Huang et al. · 2020 · American Journal of Cancer Research

Full title: Fueling chimeric antigen receptor T cells with cytokines.

Authors: Jin Jin; Jiali Cheng; Meijuan Huang; Hui Luo; Jianfeng Zhou

Year: 2020

Venue: American Journal of Cancer Research

Paper Platelet lysate boosts transgene levels and maintains undifferentiated T cell subtypes following lentiviral delivery to human primary T cells

C. T. Dann; B. McSwain; S. Charlebois et al. · 2019

Full title: Platelet lysate boosts transgene levels and maintains undifferentiated T cell subtypes following lentiviral delivery to human primary T cells

Authors: C. T. Dann; B. McSwain; S. Charlebois; E. Canestrari

Year: 2019

Paper A small-molecule/cytokine combination enhances hematopoietic stem cell proliferation via inhibition of cell differentiation

Lan Wang; X. Guan; Huihui Wang et al. · 2017 · Stem cell research & therapeutics · DOI

Full title: A small-molecule/cytokine combination enhances hematopoietic stem cell proliferation via inhibition of cell differentiation

Authors: Lan Wang; X. Guan; Huihui Wang; Bin Shen; Yu Zhang; Zhihua Ren; Yupo Ma; Xinxin Ding; Yongping Jiang

Year: 2017

Venue: Stem cell research & therapeutics

DOI: https://doi.org/10.1186/s13287-017-0625-z

Paper Immunotherapeutic approaches to ovarian cancer treatment

Chester, Cariad; Dorigo, Oliver; Berek, Jonathan S. et al. · 2015 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Immunotherapeutic approaches to ovarian cancer treatment

Authors: Chester, Cariad; Dorigo, Oliver; Berek, Jonathan S.; Kohrt, Holbrook E.

Year: 2015

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1186/s40425-015-0051-7

Paper Ex vivo Akt inhibition promotes the generation of potent CD19CAR T cells for adoptive immunotherapy

Urak, Ryan; Walter, Miriam; Lim, Laura et al. · 2017 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Ex vivo Akt inhibition promotes the generation of potent CD19CAR T cells for adoptive immunotherapy

Authors: Urak, Ryan; Walter, Miriam; Lim, Laura; Wong, ChingLam W.; Budde, Lihua E.; Thomas, Sandra H.; Forman, Stephen J.; Wang, Xiuli

Year: 2017

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1186/s40425-017-0227-4

Paper CD4/CD8 T-Cell Selection Affects Chimeric Antigen Receptor (CAR) T-Cell Potency and Toxicity: Updated Results From a Phase I Anti-CD22 CAR T-Cell Trial.

N. Shah; S. Highfill; Haneen Shalabi et al. · 2020 · Journal of Clinical Oncology · DOI

Full title: CD4/CD8 T-Cell Selection Affects Chimeric Antigen Receptor (CAR) T-Cell Potency and Toxicity: Updated Results From a Phase I Anti-CD22 CAR T-Cell Trial.

Authors: N. Shah; S. Highfill; Haneen Shalabi; B. Yates; Jian-gang Jin; P. Wolters; A. Ombrello; S. Steinberg; Staci Martin; Cindy P. Delbrook; L. Hoffman; Lauren Little; Anusha Ponduri; Haiying Qin; Haris Qureshi; Alina Dulau-Florea; Dalia A. Salem; Hao-Wei Wang; C. Yuan; M. Stetler-Stevenson; S. Panch; Minh Tran; C. Mackall; D. Stroncek; T. Fry

Year: 2020

Venue: Journal of Clinical Oncology

DOI: https://doi.org/10.1200/jco.19.03279

Paper Early transduction produces highly functional chimeric antigen receptor-modified virus-specific T-cells with central memory markers: a Production Assistant for Cell Therapy (PACT) translational application

Jiali Sun; L. Huye; N. Lapteva et al. · 2015 · Journal of Immunotherapy for Cancer · DOI

Full title: Early transduction produces highly functional chimeric antigen receptor-modified virus-specific T-cells with central memory markers: a Production Assistant for Cell Therapy (PACT) translational application

Authors: Jiali Sun; L. Huye; N. Lapteva; Maksim Mamonkin; Manasa Hiregange; B. Ballard; O. Dakhova; D. Raghavan; A. Durett; S. Perna; Bilal Omer; L. Rollins; A. Leen; J. Vera; G. Dotti; A. Gee; M. Brenner; D. Myers; C. Rooney

Year: 2015

Venue: Journal of Immunotherapy for Cancer

DOI: https://doi.org/10.1186/s40425-015-0049-1

Paper CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation

Bajgain, Pradip; Tawinwung, Supannikar; D’Elia, Lindsey et al. · 2018 · Journal for ImmunoTherapy of Cancer · DOI

Full title: CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation

Authors: Bajgain, Pradip; Tawinwung, Supannikar; D’Elia, Lindsey; Sukumaran, Sujita; Watanabe, Norihiro; Hoyos, Valentina; Lulla, Premal; Brenner, Malcolm K.; Leen, Ann M.; Vera, Juan F.

Year: 2018

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1186/s40425-018-0347-5

Paper CD62L enrichment achieves robust expansion and memory phenotype post-infusion in patients with LBCL treated with rondecabtagene autoleucel, an autologous, dual-targeting CD19/CD20 CAR T-cell candidate

Akil A Merchant; B. Harris; Lora Zhao et al. · 2025 · Blood · DOI

Full title: CD62L enrichment achieves robust expansion and memory phenotype post-infusion in patients with LBCL treated with rondecabtagene autoleucel, an autologous, dual-targeting CD19/CD20 CAR T-cell candidate

Authors: Akil A Merchant; B. Harris; Lora Zhao; Sahithi Cheemalamarri; Sobha Potluri; T. Latif; Umar Farooq; Sarah M. Larson

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood-2025-501

Paper CTD402: Allogeneic CAR-t manufacturing that overcomes donor- & process-derived variation with robust clinical activity

Xiaojing Zhang; Liping Zhu; Mengyao Wang et al. · 2025 · Blood · DOI

Full title: CTD402: Allogeneic CAR-t manufacturing that overcomes donor- & process-derived variation with robust clinical activity

Authors: Xiaojing Zhang; Liping Zhu; Mengyao Wang; Shuhui Yu; Yu Liu; Mingxi Chen; Yanbo Liu; Yong Yu; Maria del Rosario; Wengang Ge; Jan Davidson-Moncada; Yajin Ni; Jiangtao Ren

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood-2025-4180

Paper Dex and IL-7 enhance persistence of CAR T cells to promote long-term remission in mouse models of multiple myeloma

Ryan Urak; Alexandra A. Wolfarth; Donghoon Choi et al. · 2025 · Blood · DOI

Full title: Dex and IL-7 enhance persistence of CAR T cells to promote long-term remission in mouse models of multiple myeloma

Authors: Ryan Urak; Alexandra A. Wolfarth; Donghoon Choi; Stephen J Forman; Xiuli Wang

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood-2025-5878

Paper IMV101, a novel CD19-targeted In Vivo CAR T therapy exhibits potent efficacy and tolerable safety profiles in preclinical models

Shuangshuang Zhang; Yantao Li; Xiaojiang Fan et al. · 2025 · Blood · DOI

Full title: IMV101, a novel CD19-targeted In Vivo CAR T therapy exhibits potent efficacy and tolerable safety profiles in preclinical models

Authors: Shuangshuang Zhang; Yantao Li; Xiaojiang Fan; Q. Yi; Yue Zhang; Linke Bian; Jiufei Zhu; Minmin Sun; Zhenggang Jiang; Ruidong Hao

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood-2025-5875

Paper Synergistic enhancement of γδ T cell cytotoxicity against tumor spheroids through B7H3 CAR and zoledronate sensitization

Aylin Sassor; Nayana Nambiar; R. Orentas et al. · 2025 · Blood · DOI

Full title: Synergistic enhancement of γδ T cell cytotoxicity against tumor spheroids through B7H3 CAR and zoledronate sensitization

Authors: Aylin Sassor; Nayana Nambiar; R. Orentas; Congcong Zhang; Jose Villacorta Hidalgo

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood-2025-7634

Paper More than IL-2: Optimizing feeder-free NK cell function through cytokine synergy

Maxima Warmuzová; Klára Baďurová; Z. Chyra et al. · 2025 · Blood · DOI

Full title: More than IL-2: Optimizing feeder-free NK cell function through cytokine synergy

Authors: Maxima Warmuzová; Klára Baďurová; Z. Chyra; Daniela Gachová; Agáta Kubíčková; Jamal Alzubi; M. Šimíček; T. Jelínek; Jana Kotulová; R. Hájek

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood-2025-5966

Paper New class of dual agonistic T-cell engagers for the in-patient activation and expansion of v delta 1 T cells with broad antigen agnostic antitumour activity

Andre Simoes; Jarek Juraszek; Giulio Bocconcelli et al. · 2025 · Blood · DOI

Full title: New class of dual agonistic T-cell engagers for the in-patient activation and expansion of v delta 1 T cells with broad antigen agnostic antitumour activity

Authors: Andre Simoes; Jarek Juraszek; Giulio Bocconcelli; Kaavya Srikanth; Robert Friesen; Oliver Nussbaumer

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood-2025-6105

Paper Pre-clinical characterization and process development of a BCMA-directed CAR NK-cell therapy product for relapsed/refractory multiple myeloma

Charles Yin; Angela Hamie; Janna Kozuska et al. · 2025 · Blood · DOI

Full title: Pre-clinical characterization and process development of a BCMA-directed CAR NK-cell therapy product for relapsed/refractory multiple myeloma

Authors: Charles Yin; Angela Hamie; Janna Kozuska; C. Debes-Marun; Bee Tan; Pankajkumar Tailor; M. Chu

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood-2025-7650

Paper A Phase 1 study evaluating NT-I7 (efineptakin alfa), a long-acting human IL-7, post-tisagenlecleucel (tisa-cel), post-axicabtagene ciloleucel (axi-cel), or post-lisocabtagene maraleucel (liso-cel) in Relapsed/Refractory large B-cell lymphoma

Zachary D. Crees; Armin Ghobadi; E. Budde et al. · 2025 · Blood · DOI

Full title: A Phase 1 study evaluating NT-I7 (efineptakin alfa), a long-acting human IL-7, post-tisagenlecleucel (tisa-cel), post-axicabtagene ciloleucel (axi-cel), or post-lisocabtagene maraleucel (liso-cel) in Relapsed/Refractory large B-cell lymphoma

Authors: Zachary D. Crees; Armin Ghobadi; E. Budde; Ahmed Galal; Chenyu Lin; Donghoon Choi; Sun-Kyoung Im; Hye Jeong; Alex Oh; M. Rettig; John F DiPersio

Year: 2025

Venue: Blood

DOI: https://doi.org/10.1182/blood-2025-926

Paper Improving T-cell expansion and function for adoptive T-cell therapy using ex vivo treatment with PI3Kδ inhibitors and VIP antagonists

Petersen, Christopher T.; Hassan, Mojibade; Morris, Anna B. et al. · 2018 · Blood Advances · DOI

Full title: Improving T-cell expansion and function for adoptive T-cell therapy using ex vivo treatment with PI3Kδ inhibitors and VIP antagonists

Authors: Petersen, Christopher T.; Hassan, Mojibade; Morris, Anna B.; Jeffery, Jasmin; Lee, Kunhee; Jagirdar, Neera; Staton, Ashley D.; Raikar, Sunil S.; Spencer, H. Trent; Sulchek, Todd; Flowers, Christopher R.; Waller, Edmund K.

Year: 2018

Venue: Blood Advances

DOI: https://doi.org/10.1182/bloodadvances.2017011254

Paper Ex Vivo Expansion of Umbilical Cord Blood T Cells for Adoptive Immunotherapy.

M. Mazur; Young-Ah Lee; K. Joanne et al. · 2005 · DOI

Full title: Ex Vivo Expansion of Umbilical Cord Blood T Cells for Adoptive Immunotherapy.

Authors: M. Mazur; Young-Ah Lee; K. Joanne; S. Paul

Year: 2005

DOI: https://doi.org/10.1182/blood.v106.11.35.35

Paper Analysis of polyfunctionality for enhanced BAFF-R CAR T-cell therapy for hematologic malignancies.

Dong, Zhengyuan; Budde, L Elizabeth; Oh, Elizabeth et al. · 2024 · Blood advances · DOI

Full title: Analysis of polyfunctionality for enhanced BAFF-R CAR T-cell therapy for hematologic malignancies.

Authors: Dong, Zhengyuan; Budde, L Elizabeth; Oh, Elizabeth; Szymura, Szymon; Anderson, Aaron; Del Real, Marissa; Cha, Soung-Chul; Forman, Stephen J; Kwak, Larry W; Wang, Xiuli

Year: 2024

Venue: Blood advances

DOI: https://doi.org/10.1182/bloodadvances.2024013195

Paper Real-world characteristics of T-cell apheresis and clinical response to tisagenlecleucel in B-cell lymphoma

Alexis Cuffel; V. Allain; L. Faivre et al. · 2022 · Blood Advances · DOI

Full title: Real-world characteristics of T-cell apheresis and clinical response to tisagenlecleucel in B-cell lymphoma

Authors: Alexis Cuffel; V. Allain; L. Faivre; Roberta Di Blasi; F. Morin; L. Vercellino; M. Chevalier; A. Desnoyer; R. de Jorna; I. Madelaine; N. Parquet; A. Brignier; C. Thieblemont; J. Larghero; S. Caillat-Zucman; M. Mebarki

Year: 2022

Venue: Blood Advances

DOI: https://doi.org/10.1182/bloodadvances.2022007057

Paper Engineered Antigen- Presenting Cells Expressing Human HLA Class-II DR Alleles Support Efficient Enrichment and Expansion of Antigen Specific Th1 CD4[+] T-Cells Which Are Functionally Augmented by IL-15Rα/IL-15 Complexes

A. Hasan; R. Ricafort; A. Selvakumar et al. · 2012 · DOI

Full title: Engineered Antigen- Presenting Cells Expressing Human HLA Class-II DR Alleles Support Efficient Enrichment and Expansion of Antigen Specific Th1 CD4[+] T-Cells Which Are Functionally Augmented by IL-15Rα/IL-15 Complexes

Authors: A. Hasan; R. Ricafort; A. Selvakumar; E. Doubrovina; I. Rivière; M. Sadelain; R. O'reilly

Year: 2012

DOI: https://doi.org/10.1182/blood.v120.21.1905.1905

Paper Optimization of a Cytokine Cocktail for the Expansion of Cord Blood CD34+ Cells into Megakaryocytes Progenitors.

L. Boyer; Valérie Cortin; A. Robert et al. · 2007 · DOI

Full title: Optimization of a Cytokine Cocktail for the Expansion of Cord Blood CD34+ Cells into Megakaryocytes Progenitors.

Authors: L. Boyer; Valérie Cortin; A. Robert; N. Pineault

Year: 2007

DOI: https://doi.org/10.1182/blood.v110.11.4041.4041

Paper IL-7 along with Optimized CD3/CD28 Artificial APC Beads Promotes Ex Vivo Expansion of Cord Blood T Cells towards Adoptive Immunotherapy.

Craig C Davis; M. Mazur; P. Szabolcs · 2007 · DOI

Full title: IL-7 along with Optimized CD3/CD28 Artificial APC Beads Promotes Ex Vivo Expansion of Cord Blood T Cells towards Adoptive Immunotherapy.

Authors: Craig C Davis; M. Mazur; P. Szabolcs

Year: 2007

DOI: https://doi.org/10.1182/blood.v110.11.2992.2992

Paper Optimizing the Manufacture of CAR-T Cells for Clinical Applications

P. Bajgain; Roopa Mucharla; U. Anurathapan et al. · 2012 · DOI

Full title: Optimizing the Manufacture of CAR-T Cells for Clinical Applications

Authors: P. Bajgain; Roopa Mucharla; U. Anurathapan; N. Lapteva; A. Leen; H. Heslop; C. Rooney; J. Vera

Year: 2012

DOI: https://doi.org/10.1182/blood.v120.21.348.348

Paper Engineering of CD19-CAR T Cells from Non-Hodgkin Lymphoma Patients in a Closed System in Combination with Retronectin/OKT3 Stimulation

H. Chono; Kenichi Tahara; I. Nukaya et al. · 2014 · DOI

Full title: Engineering of CD19-CAR T Cells from Non-Hodgkin Lymphoma Patients in a Closed System in Combination with Retronectin/OKT3 Stimulation

Authors: H. Chono; Kenichi Tahara; I. Nukaya; J. Mineno; E. Uehara; Tomonori Tsukahara; K. Ohmine; K. Ozawa; K. Takesako

Year: 2014

DOI: https://doi.org/10.1182/blood.v124.21.2446.2446

Paper T Cell Products of Defined CD4:CD8 Composition and Prescribed Levels of CD19CAR/Egfrt Transgene Expression Mediate Regression of Acute Lymphoblastic Leukemia in the Setting of Post-Allohsct Relapse

R. Gardner; Julie R. Park; K. Kelly-Spratt et al. · 2014 · DOI

Full title: T Cell Products of Defined CD4:CD8 Composition and Prescribed Levels of CD19CAR/Egfrt Transgene Expression Mediate Regression of Acute Lymphoblastic Leukemia in the Setting of Post-Allohsct Relapse

Authors: R. Gardner; Julie R. Park; K. Kelly-Spratt; O. Finney; H. Smithers; Virginia J. Hoglund; Christopher Brown; Stephanie Mgebroff; C. Lindgren; A. Oron; M. Bleakley; M. Jensen

Year: 2014

DOI: https://doi.org/10.1182/blood.v124.21.3711.3711

Paper Cord Blood Derived Natural Killer Cells Engineered with a Chimeric Antigen Receptor Targeting CD19 and Expressing IL-15 Have Long Term Persistence and Exert Potent Anti-Leukemia Activity

E. Liu; Y. Tong; G. Dotti et al. · 2015 · DOI

Full title: Cord Blood Derived Natural Killer Cells Engineered with a Chimeric Antigen Receptor Targeting CD19 and Expressing IL-15 Have Long Term Persistence and Exert Potent Anti-Leukemia Activity

Authors: E. Liu; Y. Tong; G. Dotti; B. Savoldo; M. Muftuoglu; Kayo Kondo; M. Mukherjee; J. Orange; Catherine E. Sobieski; A. Alsuliman; Hila Shaim; N. Imahashi; M. Keating; C. Hosing; N. Shah; W. Wierda; R. Champlin; E. Shpall; K. Rezvani

Year: 2015

DOI: https://doi.org/10.1182/blood.v126.23.3091.3091

Paper Cyclophosphamide and Fludarabine Conditioning Chemotherapy Induces a Key Homeostatic Cytokine Profile in Patients Prior to CAR T Cell Therapy

Bot, Adrian; Rossi, John M.; Jiang, Yizhou et al. · 2015 · Blood · DOI

Full title: Cyclophosphamide and Fludarabine Conditioning Chemotherapy Induces a Key Homeostatic Cytokine Profile in Patients Prior to CAR T Cell Therapy

Authors: Bot, Adrian; Rossi, John M.; Jiang, Yizhou; Navale, Lynn; Shen, Yueh-wei; Sherman, Marika; Mardiros, Armen; Yoder, Sean C.; Go, William Y.; Rosenberg, Steven A.; Wiezorek, Jeff; Chang, David; Kochenderfer, James N.; Roberts, Margo R.

Year: 2015

Venue: Blood

DOI: https://doi.org/10.1182/blood.v126.23.4426.4426

Paper Myeloid Cells in Peripheral Blood Mononuclear Cell (PMBC) Concentrates Inhibit the Expansion of Chimeric Antigen Receptor (CAR) T Cells

D. Stroncek; Daniel W. Lee; Jiaqiang Ren et al. · 2015 · DOI

Full title: Myeloid Cells in Peripheral Blood Mononuclear Cell (PMBC) Concentrates Inhibit the Expansion of Chimeric Antigen Receptor (CAR) T Cells

Authors: D. Stroncek; Daniel W. Lee; Jiaqiang Ren; M. Sabatino; H. Khuu; M. Merchant; C. Mackall

Year: 2015

DOI: https://doi.org/10.1182/blood.v126.23.383.383

Paper CD19CAR T Cell Products of Defined CD4:CD8 Composition and Transgene Expression Show Prolonged Persistence and Durable MRD-Negative Remission in Pediatric and Young Adult B-Cell ALL

R. Gardner; O. Finney; H. Smithers et al. · 2016 · DOI

Full title: CD19CAR T Cell Products of Defined CD4:CD8 Composition and Transgene Expression Show Prolonged Persistence and Durable MRD-Negative Remission in Pediatric and Young Adult B-Cell ALL

Authors: R. Gardner; O. Finney; H. Smithers; K. Leger; Colleen Annesley; C. Summers; Christopher Brown; Stephanie Mgebroff; C. Lindgren; K. Spratt; A. Oron; Daniel H. Li; M. Bleakley; Julie R. Park; M. Jensen

Year: 2016

DOI: https://doi.org/10.1182/blood.v128.22.219.219

Paper Production of Anti-CD19 CAR T Cells for ZUMA-3 and -4: Phase 1/2 Multicenter Studies Evaluating KTE-C19 in Patients With Relapsed/Refractory B-Precursor Acute Lymphoblastic Leukemia (R/R ALL)

M. Sabatino; Kenny Choi; V. Chiruvolu et al. · 2016 · DOI

Full title: Production of Anti-CD19 CAR T Cells for ZUMA-3 and -4: Phase 1/2 Multicenter Studies Evaluating KTE-C19 in Patients With Relapsed/Refractory B-Precursor Acute Lymphoblastic Leukemia (R/R ALL)

Authors: M. Sabatino; Kenny Choi; V. Chiruvolu; M. Better

Year: 2016

DOI: https://doi.org/10.1182/blood.v128.22.1227.1227

Paper CAR-T Cell Production Using the Clinimacs® Prodigy System

F. Zhu; N. Shah; Huiqing Xu et al. · 2016 · DOI

Full title: CAR-T Cell Production Using the Clinimacs® Prodigy System

Authors: F. Zhu; N. Shah; Huiqing Xu; D. Schneider; R. Orentas; B. Dropulić; P. Hari; C. Keever-Taylor

Year: 2016

DOI: https://doi.org/10.1182/blood.v128.22.5724.5724

Paper Detection and Characterization of Primitive Malignant and Normal Progenitors in Patients With Acute Myelogenous Leukemia Using Long-Term Coculture With Supportive Feeder Layers and Cytokines

Ailles, Laurie; Gerhard, Brigitte; Hogge, Donna E. · 1997 · Blood · DOI

Full title: Detection and Characterization of Primitive Malignant and Normal Progenitors in Patients With Acute Myelogenous Leukemia Using Long-Term Coculture With Supportive Feeder Layers and Cytokines

Authors: Ailles, Laurie; Gerhard, Brigitte; Hogge, Donna E.

Year: 1997

Venue: Blood

DOI: https://doi.org/10.1182/blood.v90.7.2555

Paper A simple and robust clinical manufacturing process for the ex-vivo expansion of autologous T cells genetically engineered to express an anti-BCMA chimeric antigen receptor (CAR) for the treatment of multiple myeloma

Alden Ladd; Graham W. G. Lilley; Mingli Li et al. · 2015 · Journal of Immunotherapy for Cancer · DOI

Full title: A simple and robust clinical manufacturing process for the ex-vivo expansion of autologous T cells genetically engineered to express an anti-BCMA chimeric antigen receptor (CAR) for the treatment of multiple myeloma

Authors: Alden Ladd; Graham W. G. Lilley; Mingli Li; Daniel Cossette; Gregory Hopkins; Dawn A. Maier; M. Paglia; R. Morgan

Year: 2015

Venue: Journal of Immunotherapy for Cancer

DOI: https://doi.org/10.1186/2051-1426-3-s2-p117

Paper Generating Antigen‐Specific Regulatory T Cells in the Fast Lane

Leonardo M. R. Ferreira; Q. Tang · 2017 · American Journal of Transplantation · DOI

Full title: Generating Antigen‐Specific Regulatory T Cells in the Fast Lane

Authors: Leonardo M. R. Ferreira; Q. Tang

Year: 2017

Venue: American Journal of Transplantation

DOI: https://doi.org/10.1111/ajt.14202

Paper CD3ζ-based chimeric antigen receptors mediate T cell activation viacis- andtrans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy

Bridgeman, John S.; Ladell, Kristin; Sheard, Victoria et al. · 2013 · Clinical & Experimental Immunology · DOI

Full title: CD3ζ-based chimeric antigen receptors mediate T cell activation viacis- andtrans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy

Authors: Bridgeman, John S.; Ladell, Kristin; Sheard, Victoria; Miners, Kelly L.; Hawkins, Robert E.; Price, David A.; Gilham, David E.

Year: 2013

Venue: Clinical & Experimental Immunology

DOI: https://doi.org/10.1111/cei.12216

Paper Expansion deficiency of CAR‐T cells in patients with lymphoma and resolution by T cell purification

Lvzhe Chen; Shiqi Li; Meiling Wang et al. · 2019 · British Journal of Haematology · DOI

Full title: Expansion deficiency of CAR‐T cells in patients with lymphoma and resolution by T cell purification

Authors: Lvzhe Chen; Shiqi Li; Meiling Wang; Yunyan Li; Zhouxing Xiong; Rui Zhang; Yanmin Xu; Zixuan Huang; Linling Wang; Sanbin Wang; Zhi Yang; C. Qian

Year: 2019

Venue: British Journal of Haematology

DOI: https://doi.org/10.1111/bjh.15822

Paper Current status of chimeric antigen receptor therapy for haematological malignancies

Maude, Shannon L.; Barrett, David M. · 2015 · British Journal of Haematology · DOI

Full title: Current status of chimeric antigen receptor therapy for haematological malignancies

Authors: Maude, Shannon L.; Barrett, David M.

Year: 2015

Venue: British Journal of Haematology

DOI: https://doi.org/10.1111/bjh.13792

Paper Risk factors for CAR‐T cell manufacturing failure among DLBCL patients: A nationwide survey in Japan

Tomoyasu Jo; S. Yoshihara; Y. Okuyama et al. · 2023 · British Journal of Haematology · DOI

Full title: Risk factors for CAR‐T cell manufacturing failure among DLBCL patients: A nationwide survey in Japan

Authors: Tomoyasu Jo; S. Yoshihara; Y. Okuyama; K. Fujii; Tomoko Henzan; K. Kahata; R. Yamazaki; Wataru Takeda; Yoshihiro Umezawa; K. Fukushima; T. Ashida; M. Yamada-Fujiwara; Ryo Hanajiri; N. Yonetani; Y. Tada; Y. Shimura; Hidekazu Nishikii; Norio Shiba; N. Mimura; J. Ando; Takayuki Sato; Y. Nakashima; Junko Ikemoto; Keita Iwaki; Shin-ichiro Fujiwara; M. Ri; T. Nagamura-Inoue; R. Tanosaki; Y. Arai

Year: 2023

Venue: British Journal of Haematology

DOI: https://doi.org/10.1111/bjh.18831

Paper Coengineering specificity, safety, and function into T cells for cancer immunotherapy

G. M. P. Giordano Attianese; Sarah Ash; M. Irving · 2023 · Immunological Reviews · DOI

Full title: Coengineering specificity, safety, and function into T cells for cancer immunotherapy

Authors: G. M. P. Giordano Attianese; Sarah Ash; M. Irving

Year: 2023

Venue: Immunological Reviews

DOI: https://doi.org/10.1111/imr.13252

Paper Cell therapies for trauma and critical care medicine: critical issues in translation for cellular and novel therapies in trauma and critical care

D. Stroncek; A. Mathew; D. McKenna · 2019 · Transfusion · DOI

Full title: Cell therapies for trauma and critical care medicine: critical issues in translation for cellular and novel therapies in trauma and critical care

Authors: D. Stroncek; A. Mathew; D. McKenna

Year: 2019

Venue: Transfusion

DOI: https://doi.org/10.1111/trf.14832

Paper Immunotherapy and Novel Combinations in Oncology: Current Landscape, Challenges, and Opportunities

Morrissey, KM; Yuraszeck, TM; Li, Chi‐Chung et al. · 2016 · Clinical and Translational Science · DOI

Full title: Immunotherapy and Novel Combinations in Oncology: Current Landscape, Challenges, and Opportunities

Authors: Morrissey, KM; Yuraszeck, TM; Li, Chi‐Chung; Zhang, Y; Kasichayanula, Sreeneeranj

Year: 2016

Venue: Clinical and Translational Science

DOI: https://doi.org/10.1111/cts.12391

Paper Effects of starting cellular material composition on chimeric antigen receptor T-cell expansion and characteristics.

Elavia, Nasha; Panch, Sandhya R; McManus, Andrew et al. · 2019 · Transfusion · DOI

Full title: Effects of starting cellular material composition on chimeric antigen receptor T-cell expansion and characteristics.

Authors: Elavia, Nasha; Panch, Sandhya R; McManus, Andrew; Bikkani, Thejaswi; Szymanski, James; Highfill, Steven L; Jin, Ping; Brudno, Jennifer; Kochenderfer, James; Stroncek, David F

Year: 2019

Venue: Transfusion

DOI: https://doi.org/10.1111/trf.15287

Paper Enhanced T cell effector activity by targeting the Mediator kinase module

Katherine A Freitas; J. Belk; E. Sotillo et al. · 2022 · Science · DOI

Full title: Enhanced T cell effector activity by targeting the Mediator kinase module

Authors: Katherine A Freitas; J. Belk; E. Sotillo; P. J. Quinn; M. C. Ramello; Meena B. Malipatlolla; Bence Daniel; Katalin D. Sandor; D. Klysz; J. Bjelajac; Peng Xu; Kylie A. Burdsall; Victor Tieu; V. Duong; Micah G Donovan; Evan W. Weber; Howard Y. Chang; R. Majzner; J. Espinosa; Ansuman T. Satpathy; C. Mackall

Year: 2022

Venue: Science

DOI: https://doi.org/10.1126/science.abn5647

Paper CAR T cells for brain tumors: Lessons learned and road ahead

Akhavan, David; Alizadeh, Darya; Wang, Dongrui et al. · 2019 · Immunological Reviews · DOI

Full title: CAR T cells for brain tumors: Lessons learned and road ahead

Authors: Akhavan, David; Alizadeh, Darya; Wang, Dongrui; Weist, Michael R.; Shepphird, Jennifer Kelly; Brown, Christine E.

Year: 2019

Venue: Immunological Reviews

DOI: https://doi.org/10.1111/imr.12773

Paper Third-generation CD28/4-1BB chimeric antigen receptor T cells for chemotherapy relapsed or refractory acute lymphoblastic leukaemia: a non-randomised, open-label phase I trial protocol

Tang, Xiao-yi; Sun, Yao; Zhang, Ang et al. · 2016 · BMJ Open · DOI

Full title: Third-generation CD28/4-1BB chimeric antigen receptor T cells for chemotherapy relapsed or refractory acute lymphoblastic leukaemia: a non-randomised, open-label phase I trial protocol

Authors: Tang, Xiao-yi; Sun, Yao; Zhang, Ang; Hu, Guoliang; Cao, Wei; Wang, Danhong; Zhang, Bin; Chen, Hu

Year: 2016

Venue: BMJ Open

DOI: https://doi.org/10.1136/bmjopen-2016-013904

Paper Impact of cellular composition and T‐cell senescence of mononuclear cell concentrates on the manufacturing process of chimeric antigen receptor (CAR) T‐cells

V. Vučinić; T. Tumewu; M. Brückner et al. · 2025 · Transfusion · DOI

Full title: Impact of cellular composition and T‐cell senescence of mononuclear cell concentrates on the manufacturing process of chimeric antigen receptor (CAR) T‐cells

Authors: V. Vučinić; T. Tumewu; M. Brückner; J. Kirchberg; M. Jentzsch; Raymund Buhmann; Y. Remane; Sandra Hoffmann; F. Ramdohr; M. Merz; K. Metzeler; S. Schwind; C. Herling; S. Krauß; M. Herling; G. Franke; N. Grieb; Georg Stachel; M. Janz; O. Penack; Lars Bullinger; Ulrich Keller; Michael Cross; Reinhard Henschler; E. Bach; U. Platzbecker

Year: 2025

Venue: Transfusion

DOI: https://doi.org/10.1111/trf.18354

Paper Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified T cells.

Turtle, Cameron J; Hanafi, Laïla-Aïcha; Berger, Carolina et al. · 2016 · Science translational medicine · DOI

Full title: Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified T cells.

Authors: Turtle, Cameron J; Hanafi, Laïla-Aïcha; Berger, Carolina; Hudecek, Michael; Pender, Barbara; Robinson, Emily; Hawkins, Reed; Chaney, Colette; Cherian, Sindhu; Chen, Xueyan; Soma, Lorinda; Wood, Brent; Li, Daniel; Heimfeld, Shelly; Riddell, Stanley R; Maloney, David G

Year: 2016

Venue: Science translational medicine

DOI: https://doi.org/10.1126/scitranslmed.aaf8621

Paper Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources

A. Schmidts; Leah C Marsh; A. Srivastava et al. · 2020 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources

Authors: A. Schmidts; Leah C Marsh; A. Srivastava; Amanda A Bouffard; Angela C. Boroughs; Irene Scarfò; R. Larson; F. Bedoya; Bryan D Choi; M. Frigault; Stefanie R. Bailey; M. Leick; Sonika Vatsa; M. Kann; Michelle S. Prew; B. Kleinstiver; J. Joung; M. Maus

Year: 2020

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2020-000990

Paper P09.08 Clinical-grade manufacturing of ROR1 CAR T cells using a novel virus-free protocol

K. Mestermann; M. Eichler; M. Machwirth et al. · 2020 · DOI

Full title: P09.08 Clinical-grade manufacturing of ROR1 CAR T cells using a novel virus-free protocol

Authors: K. Mestermann; M. Eichler; M. Machwirth; K. Kebbel; U. Köhl; H. Einsele; C. Müller; J. Lehmann; T. Rasko; F. Lundberg; Z. Izsvák; G. Schmiedeknecht; M. Hudecek

Year: 2020

DOI: https://doi.org/10.1136/jitc-2020-itoc7.108

Paper TSTEM-like CAR-T cells exhibit improved persistence and tumor control compared with conventional CAR-T cells in preclinical models

D. Meyran; J. Zhu; Jeannene Butler et al. · 2023 · Science Translational Medicine · DOI

Full title: TSTEM-like CAR-T cells exhibit improved persistence and tumor control compared with conventional CAR-T cells in preclinical models

Authors: D. Meyran; J. Zhu; Jeannene Butler; Daniela Tantalo; Sean Macdonald; T. Nguyen; Minyu Wang; N. Thio; C. D’Souza; V. Qin; C. Slaney; Aaron J Harrison; K. Sek; P. Petrone; K. Thia; Lauren Giuffrida; A. Scott; Rachael L. Terry; B. Tran; J. Desai; H. Prince; S. Harrison; P. Beavis; M. Kershaw; B. Solomon; P. Ekert; J. Trapani; P. Darcy; P. Neeson

Year: 2023

Venue: Science Translational Medicine

DOI: https://doi.org/10.1126/scitranslmed.abk1900

Paper Adoptive cellular therapy in solid tumor malignancies: review of the literature and challenges ahead

Kirtane, Kedar; Elmariah, Hany; Chung, Christine H. et al. · 2021 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Adoptive cellular therapy in solid tumor malignancies: review of the literature and challenges ahead

Authors: Kirtane, Kedar; Elmariah, Hany; Chung, Christine H.; Abate‐Daga, Daniel

Year: 2021

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2021-002723

Paper Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune effector cell-related adverse events

Maus, Marcela V.; Alexander, S.; Bishop, Michael R. et al. · 2020 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune effector cell-related adverse events

Authors: Maus, Marcela V.; Alexander, S.; Bishop, Michael R.; Brudno, Jennifer N.; Callahan, Colleen; Davila, Marco L.; Diamonte, Claudia; Dietrich, Jörg; Fitzgerald, Julie C.; Frigault, Matthew J.; Fry, Terry J.; Holter‐Chakrabarty, Jennifer; Komanduri, Krishna V.; Lee, Daniel W; Locke, Frederick L.; Maude, Shannon L.; McCarthy, Philip L.; Mead, Elena; Neelapu, Sattva S.; Neilan, Tomas G.; Santomasso, Bianca; Shpall, Elizabeth J.; Teachey, David T.; Turtle, Cameron J.; Whitehead, Thomas M.; Grupp, Stephan A.

Year: 2020

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2020-001511

Paper 164 AgenT-797, a novel allogenic and ‘off-the shelf’ iNKT cell therapy promotes effective tumor killing

B. Yigit; X. Michelet; S. Kharkwal et al. · 2020 · DOI

Full title: 164 AgenT-797, a novel allogenic and ‘off-the shelf’ iNKT cell therapy promotes effective tumor killing

Authors: B. Yigit; X. Michelet; S. Kharkwal; Eleni Chantzoura; J. Bergmann; A. S. Yague; S. Yue; D. Moskowitz; B. Wolf; M. Exley; D. Chand; M. Dijk

Year: 2020

DOI: https://doi.org/10.1136/jitc-2020-sitc2020.0164

Paper Exercise and the immune system: taking steps to improve responses to cancer immunotherapy

Gustafson, Michael P.; Wheatley, Courtney M.; Rosenthal, Allison et al. · 2021 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Exercise and the immune system: taking steps to improve responses to cancer immunotherapy

Authors: Gustafson, Michael P.; Wheatley, Courtney M.; Rosenthal, Allison; Gastineau, Dennis A.; Katsanis, Emmanuel; Johnson, Bruce D.; Simpson, Richard J.

Year: 2021

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2020-001872

Paper 830 Targeting cellular senescence to increase CAR-T cell fitness

R. Bankoti; H. Akbal; M. Adorno et al. · 2020 · Journal for ImmunoTherapy of Cancer · DOI

Full title: 830 Targeting cellular senescence to increase CAR-T cell fitness

Authors: R. Bankoti; H. Akbal; M. Adorno; Benedetta Nicolis di Robilant

Year: 2020

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2020-sitc2020.0830

Paper 4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells

Roselli, Emiliano; Boucher, Justin C.; Li, Gongbo et al. · 2021 · Journal for ImmunoTherapy of Cancer · DOI

Full title: 4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells

Authors: Roselli, Emiliano; Boucher, Justin C.; Li, Gongbo; Kotani, Hiroshi; Spitler, Kristen; Reid, Kayla; Cervantes, Estelle V.; Bulliard, Yannick; Tu, Nhan; Lee, Sae Bom; Yu, Bin; Locke, Frederick L.; Davila, Marco L.

Year: 2021

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2021-003354

Paper Targeting disialoganglioside GD2 with chimeric antigen receptor-redirected T cells in lung cancer

Reppel, Loïc; Tsahouridis, Ourania; Akulian, Jason et al. · 2022 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Targeting disialoganglioside GD2 with chimeric antigen receptor-redirected T cells in lung cancer

Authors: Reppel, Loïc; Tsahouridis, Ourania; Akulian, Jason; Davis, Ian J.; Lee, Hong; Fucà, Giovanni; Weiss, Jared; Dotti, Gianpietro; Pecot, Chad V.; Savoldo, Barbara

Year: 2022

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2021-003897

Paper Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design.

Qin, Haiying; Yang, Lila; Chukinas, John A et al. · 2021 · Journal for immunotherapy of cancer · DOI

Full title: Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design.

Authors: Qin, Haiying; Yang, Lila; Chukinas, John A; Shah, Nirali; Tarun, Samiksha; Pouzolles, Marie; Chien, Christopher D; Niswander, Lisa M; Welch, Anthony R; Taylor, Naomi; Tasian, Sarah K; Fry, Terry J

Year: 2021

Venue: Journal for immunotherapy of cancer

DOI: https://doi.org/10.1136/jitc-2021-003149

Paper Large-scale manufacturing and characterization of CMV-CD19CAR T cells

Xiuli Wang; Ryan Urak; M. Walter et al. · 2022 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Large-scale manufacturing and characterization of CMV-CD19CAR T cells

Authors: Xiuli Wang; Ryan Urak; M. Walter; Min Guan; Tianxu Han; Vibhuti Vyas; S. Chien; Brenna J. Gittins; Mary C. Clark; S. Mokhtari; Angelo Cardoso; D. Diamond; J. Zaia; S. Forman; R. Nakamura

Year: 2022

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2021-003461

Paper Understanding T cell phenotype for the design of effective chimeric antigen receptor T cell therapies

Tantalo, Daniela; Oliver, Amanda J.; Scheidt, Bianca von et al. · 2021 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Understanding T cell phenotype for the design of effective chimeric antigen receptor T cell therapies

Authors: Tantalo, Daniela; Oliver, Amanda J.; Scheidt, Bianca von; Harrison, Aaron J; Mueller, Scott N.; Kershaw, Michael H.; Slaney, Clare Y.

Year: 2021

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2021-002555

Paper 117 Rapid point-of-care subcutaneous CAR-T from blood draw to injection in 4 hours with modified LV encoding CARs and synthetic driver elements enables efficient CAR-T expansion and tumor regression

Frédéric Vigant; Qun He; Wei Zhang et al. · 2020 · Journal for ImmunoTherapy of Cancer · DOI

Full title: 117 Rapid point-of-care subcutaneous CAR-T from blood draw to injection in 4 hours with modified LV encoding CARs and synthetic driver elements enables efficient CAR-T expansion and tumor regression

Authors: Frédéric Vigant; Qun He; Wei Zhang; H. Zong; A. Kundu; E. Jaruga-Killeen; G. Schreiber; Michelle Andraza; Alissa R. Kerner; G. Frost

Year: 2020

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2020-sitc2020.0117

Paper Modulating TNFα activity allows transgenic IL15-Expressing CLL-1 CAR T cells to safely eliminate acute myeloid leukemia

Atilla, Pınar Ataca; McKenna, Mary K.; Tashiro, Haruko et al. · 2020 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Modulating TNFα activity allows transgenic IL15-Expressing CLL-1 CAR T cells to safely eliminate acute myeloid leukemia

Authors: Atilla, Pınar Ataca; McKenna, Mary K.; Tashiro, Haruko; Srinivasan, Madhuwanti; Mo, Feiyan; Watanabe, Norihiro; Simons, Brian W.; Stevens, Alexandra M.; Redell, Michele S.; Heslop, Helen E.; Mamonkin, Maksim; Brenner, Malcolm K.; Atilla, Erden

Year: 2020

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2020-001229

Paper Emerging organoid-immune co-culture models for cancer research: from oncoimmunology to personalized immunotherapies

Magré, Luc; Verstegen, Monique M.A.; Buschow, Sonja I. et al. · 2023 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Emerging organoid-immune co-culture models for cancer research: from oncoimmunology to personalized immunotherapies

Authors: Magré, Luc; Verstegen, Monique M.A.; Buschow, Sonja I.; Laan, Luc J. W. van der; Peppelenbosch, Maikel P.; Desai, Jyaysi

Year: 2023

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2022-006290

Paper Engineering CAR-NK cells to secrete IL-15 sustains their anti-AML functionality but is associated with systemic toxicities

Christodoulou, Ilias; Ho, Won Jin; Marple, Andrew et al. · 2021 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Engineering CAR-NK cells to secrete IL-15 sustains their anti-AML functionality but is associated with systemic toxicities

Authors: Christodoulou, Ilias; Ho, Won Jin; Marple, Andrew; Ravich, Jonas W.; Tam, Ada; Rahnama, Ruyan; Fearnow, Adam D.; Rietberg, Cambrynne; Yanik, Sean; Solomou, Elena E.; Varadhan, Ravi; Koldobskiy, Michael A.; Bonifant, Challice L.

Year: 2021

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2021-003894

Paper 210 A novel medium for increased cytotoxicity and serum-minimal ex vivo expansion of natural killer (NK) cellular immunotherapies

M. Gillig; Graeme Lambert; Donna Sonntag et al. · 2021 · Journal for ImmunoTherapy of Cancer · DOI

Full title: 210 A novel medium for increased cytotoxicity and serum-minimal ex vivo expansion of natural killer (NK) cellular immunotherapies

Authors: M. Gillig; Graeme Lambert; Donna Sonntag; R. Ohri; Jason G. Cahoon; A. Shemesh; Rafet Amoor

Year: 2021

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2021-sitc2021.210

Paper Microbial short-chain fatty acids: a strategy to tune adoptive T cell therapy

Rangan, Priya; Mondino, Anna · 2022 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Microbial short-chain fatty acids: a strategy to tune adoptive T cell therapy

Authors: Rangan, Priya; Mondino, Anna

Year: 2022

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2021-004147

Paper GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma

Gargett, Tessa; Ebert, Lisa M.; Truong, Nga et al. · 2022 · Journal for ImmunoTherapy of Cancer · DOI

Full title: GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma

Authors: Gargett, Tessa; Ebert, Lisa M.; Truong, Nga; Kollis, Paris M.; Šediváková, Kristýna; Yu, Wenbo; Yeo, Erica C. F.; Wittwer, Nicole L.; Gliddon, Briony L.; Tea, Melinda N.; Ormsby, Rebecca J.; Poonnoose, Santosh; Nowicki, Jake; Vittorio, Orazio; Ziegler, David S.; Pitson, Stuart M.; Brown, Michael P.

Year: 2022

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2022-005187

Paper CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses

Bove, Camilla; Arcangeli, Silvia; Falcone, Laura et al. · 2023 · Journal for ImmunoTherapy of Cancer · DOI

Full title: CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses

Authors: Bove, Camilla; Arcangeli, Silvia; Falcone, Laura; Camisa, Barbara; Khoury, Rita El; Gréco, Béatrice; Lucia, Anna De; Bergamini, Alice; Bondanza, Attilio; Ciceri, Fabio; Bonini, Chiara; Casucci, Monica

Year: 2023

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2022-005878

Paper CD8+ chimeric antigen receptor T cells manufactured in absence of CD4+ cells exhibit hypofunctional phenotype.

Lee, Sang Yun; Lee, Dong Hoon; Sun, Wei et al. · 2023 · Journal for immunotherapy of cancer · DOI

Full title: CD8+ chimeric antigen receptor T cells manufactured in absence of CD4+ cells exhibit hypofunctional phenotype.

Authors: Lee, Sang Yun; Lee, Dong Hoon; Sun, Wei; Cervantes-Contreras, Francisco; Basom, Ryan S; Wu, Feinan; Liu, Si; Rai, Richa; Mirzaei, Hamid R; O'Steen, Shyril; Green, Damian J; Shadman, Mazyar; Till, Brian G

Year: 2023

Venue: Journal for immunotherapy of cancer

DOI: https://doi.org/10.1136/jitc-2023-007803

Paper Emerging NK cell therapies for cancer and the promise of next generation engineering of iPSC-derived NK cells

Maddineni, Sainiteesh; Silberstein, John L.; Sunwoo, John B. · 2022 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Emerging NK cell therapies for cancer and the promise of next generation engineering of iPSC-derived NK cells

Authors: Maddineni, Sainiteesh; Silberstein, John L.; Sunwoo, John B.

Year: 2022

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2022-004693

Paper Preclinical proof of concept for VivoVec, a lentiviral-based platform for in vivo CAR T-cell engineering

Kathryn Michels; A. Sheih; Susana Hernandez et al. · 2023 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Preclinical proof of concept for VivoVec, a lentiviral-based platform for in vivo CAR T-cell engineering

Authors: Kathryn Michels; A. Sheih; Susana Hernandez; Alissa H. Brandes; Don Parrilla; B. Irwin; Anai M Perez; Hung-An Ting; C. Nicolai; Tim Gervascio; Seungjin Shin; Mark D. Pankau; Mason Muhonen; J. Freeman; Sarah Gould; R. Getto; Ryan P. Larson; B. Ryu; A. Scharenberg; Alessandra M. Sullivan; Shon Green

Year: 2023

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2022-006292

Paper IL15 modification enables CAR T cells to act as a dual targeting agent against tumor cells and myeloid-derived suppressor cells in GBM

Ζαννίκου, Μαρκέλλα; Duffy, Joseph; Levine, Rebecca et al. · 2023 · Journal for ImmunoTherapy of Cancer · DOI

Full title: IL15 modification enables CAR T cells to act as a dual targeting agent against tumor cells and myeloid-derived suppressor cells in GBM

Authors: Ζαννίκου, Μαρκέλλα; Duffy, Joseph; Levine, Rebecca; Seblani, Maggie; Liu, Qianli; Presser, Aaron; Arrieta, Víctor A.; Chen, Christopher J.; Sonabend, Adam M.; Horbinski, Craig; Lee-Chang, Catalina; Miska, Jason; Lesniak, Maciej S.; Gottschalk, Stephen; Balyasnikova, Irina V.

Year: 2023

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2022-006239

Paper AKT inhibition generates potent polyfunctional clinical grade AUTO1 CAR T-cells, enhancing function and survival

Vedika Mehra; G. Agliardi; Juliana Dias Alves Pinto et al. · 2023 · Journal for ImmunoTherapy of Cancer · DOI

Full title: AKT inhibition generates potent polyfunctional clinical grade AUTO1 CAR T-cells, enhancing function and survival

Authors: Vedika Mehra; G. Agliardi; Juliana Dias Alves Pinto; Manar S Shafat; Amaia Cadinanos Garai; L. Green; A. Hotblack; F. Arce Vargas; K. Peggs; A. B. van der Waart; H. Dolstra; M. Pule; C. Roddie

Year: 2023

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2023-007002

Paper Safety and biological outcomes following a phase 1 trial of GD2-specific CAR-T cells in patients with GD2-positive metastatic melanoma and other solid cancers

T. Gargett; Nga T H Truong; B. Gardam et al. · 2024 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Safety and biological outcomes following a phase 1 trial of GD2-specific CAR-T cells in patients with GD2-positive metastatic melanoma and other solid cancers

Authors: T. Gargett; Nga T H Truong; B. Gardam; Wenbo Yu; Lisa M Ebert; Amy Johnson; Erica C F Yeo; Nicole L. Wittwer; Gonzalo Tapia Rico; Jesikah Logan; Purany Sivaloganathan; Maria Collis; Andrew Ruszkiewicz; Michael P Brown

Year: 2024

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2023-008659

Paper 330 Redirecting glucose usage during in vitro expansion improves the in vivo persistence and function of adoptive T cell therapies for cancer

A. Frisch; Yiyang Wang; Yupeng Wang et al. · 2022 · Regular and Young Investigator Award Abstracts · DOI

Full title: 330 Redirecting glucose usage during in vitro expansion improves the in vivo persistence and function of adoptive T cell therapies for cancer

Authors: A. Frisch; Yiyang Wang; Yupeng Wang; K. Lontos; Greg M. Delgoffe

Year: 2022

Venue: Regular and Young Investigator Award Abstracts

DOI: https://doi.org/10.1136/jitc-2022-sitc2022.0330

Paper 344 Comparative assessment of product quality attributes associated with production of chimeric antigen receptor T cells expressing scFv CD-19 and scFv IL-13Ra2 by two manufacturing platforms

SuJin Hwang; Heba A Degheidy; Mondona S. McCann et al. · 2022 · Regular and Young Investigator Award Abstracts · DOI

Full title: 344 Comparative assessment of product quality attributes associated with production of chimeric antigen receptor T cells expressing scFv CD-19 and scFv IL-13Ra2 by two manufacturing platforms

Authors: SuJin Hwang; Heba A Degheidy; Mondona S. McCann; S. Bauer; R. Puri; B. Joshi

Year: 2022

Venue: Regular and Young Investigator Award Abstracts

DOI: https://doi.org/10.1136/jitc-2022-sitc2022.0344

Paper Hyperleukocytosis in a neuroblastoma patient after treatment with natural killer T cells expressing a GD2-specific chimeric antigen receptor and IL-15

Gengwen Tian; Amy N. Courtney; Hangjin Yu et al. · 2025 · Journal for ImmunoTherapy of Cancer · DOI

Full title: Hyperleukocytosis in a neuroblastoma patient after treatment with natural killer T cells expressing a GD2-specific chimeric antigen receptor and IL-15

Authors: Gengwen Tian; Amy N. Courtney; Hangjin Yu; S. Bhar; Xin Xu; Gabriel A Barragán; Claudia Martinez Amador; Nisha Ghatwai; Michael S Wood; Deborah Schady; A. Montalbano; Shantan Reddy; A. Roche; David A. de la Cerda; Donald Williams Parsons; Erica J Di Pierro; Frederic D. Bushman; A. Heczey; L. Metelitsa

Year: 2025

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2024-010156

Paper Chimeric Antigen Receptor-Engineered T Cells for Immunotherapy of Cancer

Cartellieri, Marc; Bachmann, Michael; Feldmann, Anja et al. · 2010 · Journal of Biomedicine and Biotechnology · DOI

Full title: Chimeric Antigen Receptor-Engineered T Cells for Immunotherapy of Cancer

Authors: Cartellieri, Marc; Bachmann, Michael; Feldmann, Anja; Bippes, Claudia C.; Stamova, Slava; Wehner, Rebekka; Temme, Achim; Schmitz, Marc

Year: 2010

Venue: Journal of Biomedicine and Biotechnology

DOI: https://doi.org/10.1155/2010/956304

Paper A Pivotal Role for Interleukin-27 in CD8+T Cell Functions and Generation of Cytotoxic T Lymphocytes

Morishima, Noriko; Mizoguchi, Izuru; Okumura, Masae et al. · 2010 · Journal of Biomedicine and Biotechnology · DOI

Full title: A Pivotal Role for Interleukin-27 in CD8+T Cell Functions and Generation of Cytotoxic T Lymphocytes

Authors: Morishima, Noriko; Mizoguchi, Izuru; Okumura, Masae; Chiba, Yukino; Xu, Mingli; Shimizu, Motomu; Matsui, M.; Mizuguchi, Junichiro; Yoshimoto, Takayuki

Year: 2010

Venue: Journal of Biomedicine and Biotechnology

DOI: https://doi.org/10.1155/2010/605483

Paper Natural Killer Cells: From Innate to Adaptive Features

Mujal, Adriana M.; Delconte, Rebecca B.; Sun, Joseph C. · 2021 · Annual Review of Immunology · DOI

Full title: Natural Killer Cells: From Innate to Adaptive Features

Authors: Mujal, Adriana M.; Delconte, Rebecca B.; Sun, Joseph C.

Year: 2021

Venue: Annual Review of Immunology

DOI: https://doi.org/10.1146/annurev-immunol-101819-074948

Paper BCMA-BBZ-OX40 CAR-T Therapy Using an Instant Manufacturing Platform in Multiple Myeloma

Ting Wang; Yazi Yang; Lie Ma et al. · 2024 · Journal for ImmunoTherapy of Cancer · DOI

Full title: BCMA-BBZ-OX40 CAR-T Therapy Using an Instant Manufacturing Platform in Multiple Myeloma

Authors: Ting Wang; Yazi Yang; Lie Ma; Ru Feng; Jiangtao Li; Chunli Zhang; J. Bai; Yanping Ding; Guanghua Liu; Fei Wu; xinan Lu; Shi Feng; Zhenling Li; Ting He; Jian Li; Hui Liu

Year: 2024

Venue: Journal for ImmunoTherapy of Cancer

DOI: https://doi.org/10.1136/jitc-2024-009476

Paper Reprogramming CD19-Specific T Cells with IL-21 Signaling Can Improve Adoptive Immunotherapy of B-Lineage Malignancies

Singh, Harjeet; Figliola, Matthew J.; Dawson, Margaret J. et al. · 2011 · Cancer Research · DOI

Full title: Reprogramming CD19-Specific T Cells with IL-21 Signaling Can Improve Adoptive Immunotherapy of B-Lineage Malignancies

Authors: Singh, Harjeet; Figliola, Matthew J.; Dawson, Margaret J.; Huls, Helen; Olivares, Simon; Switzer, Kirsten C.; Mi, Tiejuan; Maiti, Sourindra N.; Kebriaei, Partow; Lee, Dean A.; Champlin, Richard E.; Cooper, Laurence J.N.

Year: 2011

Venue: Cancer Research

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Paper Anti-PD-1/PD-L1 Therapy for Non-Small-Cell Lung Cancer: Toward Personalized Medicine and Combination Strategies

Sui, Hongshu; Ma, Ningxia; Wang, Ying et al. · 2018 · Journal of Immunology Research · DOI

Full title: Anti-PD-1/PD-L1 Therapy for Non-Small-Cell Lung Cancer: Toward Personalized Medicine and Combination Strategies

Authors: Sui, Hongshu; Ma, Ningxia; Wang, Ying; Li, Hui; Liu, Xiaoming; Su, Yanping; Yang, Jiali

Year: 2018

Venue: Journal of Immunology Research

DOI: https://doi.org/10.1155/2018/6984948

Paper T Cell Exhaustion and CAR‐T Immunotherapy in Hematological Malignancies

Tang, Lu; Zhang, Yinqiang; Hu, Yu et al. · 2021 · BioMed Research International · DOI

Full title: T Cell Exhaustion and CAR‐T Immunotherapy in Hematological Malignancies

Authors: Tang, Lu; Zhang, Yinqiang; Hu, Yu; Mei, Heng

Year: 2021

Venue: BioMed Research International

DOI: https://doi.org/10.1155/2021/6616391

Paper Considerations for the Clinical Application of Chimeric Antigen Receptor T Cells: Observations from a Recombinant DNA Advisory Committee Symposium Held June 15, 2010

Ertl, Hildegund C.J.; Zaia, John A.; Rosenberg, Steven A. et al. · 2011 · Cancer Research · DOI

Full title: Considerations for the Clinical Application of Chimeric Antigen Receptor T Cells: Observations from a Recombinant DNA Advisory Committee Symposium Held June 15, 2010

Authors: Ertl, Hildegund C.J.; Zaia, John A.; Rosenberg, Steven A.; June, Carl H.; Dotti, Gianpietro; Kahn, Jeffrey; Cooper, Laurence J.N.; Corrigan‐Curay, Jacqueline; Strome, Scott E.

Year: 2011

Venue: Cancer Research

DOI: https://doi.org/10.1158/0008-5472.can-10-4035

Paper In vivoInhibition of Human CD19-Targeted Effector T Cells by Natural T Regulatory Cells in a Xenotransplant Murine Model of B Cell Malignancy

Lee, James; Hayman, Erik; Pegram, Hollie J. et al. · 2011 · Cancer Research · DOI

Full title: In vivoInhibition of Human CD19-Targeted Effector T Cells by Natural T Regulatory Cells in a Xenotransplant Murine Model of B Cell Malignancy

Authors: Lee, James; Hayman, Erik; Pegram, Hollie J.; Santos, Elmer; Heller, Glenn; Sadelain, Michel; Brentjens, Renier J.

Year: 2011

Venue: Cancer Research

DOI: https://doi.org/10.1158/0008-5472.can-10-0552

Paper In vitro high expansion of chimeric antigen receptor (CAR)-T cells in serum-free process conditions

W. Chi; Pei-Ju Leng; Hsin-Lin Lu et al. · 2019

Full title: In vitro high expansion of chimeric antigen receptor (CAR)-T cells in serum-free process conditions

Authors: W. Chi; Pei-Ju Leng; Hsin-Lin Lu; Yu-Hua Su

Year: 2019

Paper Title: Glypican-3-specific CAR T cells co-expressing IL15 and IL21 have superior expansion and antitumor activity against hepatocellular carcinoma Authors:

S. Batra, Purva Rathi, Linjie Guo, Amy N. Courtney, Julien Fleurence, Julien Balzeau, S. Rahamthulla, Shaik, T. Nguyen, Meng-fen Wu, Shaun Bulsara, Maksim Mamonkin, L. Metelitsa, András, Heczey · 2020

Full title: Title: Glypican-3-specific CAR T cells co-expressing IL15 and IL21 have superior expansion and antitumor activity against hepatocellular carcinoma Authors:

Authors: S. Batra, Purva Rathi, Linjie Guo, Amy N. Courtney, Julien Fleurence, Julien Balzeau, S. Rahamthulla, Shaik, T. Nguyen, Meng-fen Wu, Shaun Bulsara, Maksim Mamonkin, L. Metelitsa, András, Heczey

Year: 2020

Paper Impact of Serum/Xeno-Free Medium and Cytokine Supplementation on CAR-T Cell Therapy Manufacturing in Stirred Tank Bioreactors.

Silva Couto, Pedro; Stibbs, Dale J; Springuel, Pierre et al. · 2025 · Biotechnology journal · DOI

Full title: Impact of Serum/Xeno-Free Medium and Cytokine Supplementation on CAR-T Cell Therapy Manufacturing in Stirred Tank Bioreactors.

Authors: Silva Couto, Pedro; Stibbs, Dale J; Springuel, Pierre; Schultz, Ursula; Effenberger, Manuel; Goldrick, Stephen; Navarro-Velázquez, Sergio; Juan, Manel; Herbst, Laura; Nießing, Bastian; Mestermann, Katrin; Sanges, Carmen; Hudecek, Michael; Rafiq, Qasim A

Year: 2025

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.70114

Paper Lymphokines and cytokines as cancer treatment.Immunotherapy realized

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Full title: Lymphokines and cytokines as cancer treatment.Immunotherapy realized

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Paper Oral Injections Tested in Proof-of-Concept Trial.

Jennifer Abbasí · 2020 · Journal of the American Medical Association (JAMA) · DOI

Full title: Oral Injections Tested in Proof-of-Concept Trial.

Authors: Jennifer Abbasí

Year: 2020

Venue: Journal of the American Medical Association (JAMA)

DOI: https://doi.org/10.1001/jama.2020.1740

Paper Emerging Nano‐/Microapproaches for Cancer Immunotherapy

Mi, Yu; Hagan, C. Tilden; Vincent, Benjamin G. et al. · 2019 · Advanced Science · DOI

Full title: Emerging Nano‐/Microapproaches for Cancer Immunotherapy

Authors: Mi, Yu; Hagan, C. Tilden; Vincent, Benjamin G.; Wang, Andrew Z.

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Venue: Advanced Science

DOI: https://doi.org/10.1002/advs.201801847

Paper Demonstrating the Manufacture of Human CAR‐T Cells in an Automated Stirred‐Tank Bioreactor

E. Costariol; M. Rotondi; A. Amini et al. · 2020 · Biotechnology Journal · DOI

Full title: Demonstrating the Manufacture of Human CAR‐T Cells in an Automated Stirred‐Tank Bioreactor

Authors: E. Costariol; M. Rotondi; A. Amini; C. Hewitt; A. Nienow; T. Heathman; Q. Rafiq

Year: 2020

Venue: Biotechnology Journal

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Paper Engineering T cell receptor fusion proteins using nonviral CRISPR/Cas9 genome editing for cancer immunotherapy

R. Shu; M. Hammett; V. Evtimov et al. · 2023 · Bioengineering & Translational Medicine · DOI

Full title: Engineering T cell receptor fusion proteins using nonviral CRISPR/Cas9 genome editing for cancer immunotherapy

Authors: R. Shu; M. Hammett; V. Evtimov; Aleta Pupovac; Nhu-Y N. Nguyen; Rasa Islam; Junli Zhuang; Seyeong Lee; Tae‐hun Kang; K. Lee; I. Nisbet; Peter Hudson; J. Y. Lee; Richard L. Boyd; A. Trounson

Year: 2023

Venue: Bioengineering & Translational Medicine

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Paper Unsupervised Machine Learning‐Based Process Analytical Tools for Near Real‐Time Cell Morphology Analysis During CAR‐T Cell Manufacturing

Nidhi G Thite; Michael C Yarnell; Terry J Fry et al. · 2025 · Biotechnology and Bioengineering · DOI

Full title: Unsupervised Machine Learning‐Based Process Analytical Tools for Near Real‐Time Cell Morphology Analysis During CAR‐T Cell Manufacturing

Authors: Nidhi G Thite; Michael C Yarnell; Terry J Fry; Matthew Seefeldt; Christopher P Calderon; Theodore W Randolph

Year: 2025

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.70005

Paper Common and distinct features of cytokine effects on hematopoietic stem and progenitor cells revealed by dose–response surface analysis

J. Audet; Cindy L. Miller; C. Eaves et al. · 2002 · Biotechnology and Bioengineering · DOI

Full title: Common and distinct features of cytokine effects on hematopoietic stem and progenitor cells revealed by dose–response surface analysis

Authors: J. Audet; Cindy L. Miller; C. Eaves; J. Piret

Year: 2002

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.1002/bit.10399

Paper TRUCKS, the fourth‐generation CAR T cells: Current developments and clinical translation

Chmielewski, Markus; Abken, Hinrich · 2020 · Advances in Cell and Gene Therapy · DOI

Full title: TRUCKS, the fourth‐generation CAR T cells: Current developments and clinical translation

Authors: Chmielewski, Markus; Abken, Hinrich

Year: 2020

Venue: Advances in Cell and Gene Therapy

DOI: https://doi.org/10.1002/acg2.84

Paper A digital shadow of CAR T cell expansion in a perfusion bioreactor: Informing optimal harvest times for autologous cell therapy.

Egan, Joseph R; Marí-Buyé, Núria; Benítez-Cano, Elia Vallejo et al. · 2025 · Biotechnology progress · DOI

Full title: A digital shadow of CAR T cell expansion in a perfusion bioreactor: Informing optimal harvest times for autologous cell therapy.

Authors: Egan, Joseph R; Marí-Buyé, Núria; Benítez-Cano, Elia Vallejo; Costa, Miquel; Wanika, Linda; Chappell, Michael J; Schultz, Ursula; Ochs, Jelena; Effenberger, Manuel; Horna, David; Rafiq, Qasim; Goldrick, Stephen

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.70045

Paper Changes to culture pH and dissolved oxygen can enhance chimeric antigen receptor T-cell generation and differentiation.

Lamas, Rodrigo; Ulrey, Robert; Ahuja, Sanjeev et al. · 2022 · Biotechnology progress · DOI

Full title: Changes to culture pH and dissolved oxygen can enhance chimeric antigen receptor T-cell generation and differentiation.

Authors: Lamas, Rodrigo; Ulrey, Robert; Ahuja, Sanjeev; Sargent, Alex

Year: 2022

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3275

Paper Establishing a scalable perfusion strategy for the manufacture of CAR‐T cells in stirred‐tank bioreactors using a quality‐by‐design approach

Tiffany Hood; Pierre Springuel; F. Slingsby et al. · 2025 · Bioengineering & Translational Medicine · DOI

Full title: Establishing a scalable perfusion strategy for the manufacture of CAR‐T cells in stirred‐tank bioreactors using a quality‐by‐design approach

Authors: Tiffany Hood; Pierre Springuel; F. Slingsby; Viktor Sandner; W. Geis; Timo Schmidberger; Nicola Bevan; Quentin Vicard; J. Hengst; Noushin Dianat; Q. Rafiq

Year: 2025

Venue: Bioengineering & Translational Medicine

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Paper Chimeric antigen receptor transduced T cells: Tuning up for the next generation

Schubert, Maria‐Luisa; Hoffmann, Jean‐Marc; Dreger, Peter et al. · 2017 · International Journal of Cancer · DOI

Full title: Chimeric antigen receptor transduced T cells: Tuning up for the next generation

Authors: Schubert, Maria‐Luisa; Hoffmann, Jean‐Marc; Dreger, Peter; Müller‐Tidow, Carsten; Schmitt, Michael

Year: 2017

Venue: International Journal of Cancer

DOI: https://doi.org/10.1002/ijc.31147

Paper Ibrutinib for improved chimeric antigen receptor T‐cell production for chronic lymphocytic leukemia patients

Fan, Fuli; Yoo, Keun-Young; Stock, Sophia et al. · 2020 · International Journal of Cancer · DOI

Full title: Ibrutinib for improved chimeric antigen receptor T‐cell production for chronic lymphocytic leukemia patients

Authors: Fan, Fuli; Yoo, Keun-Young; Stock, Sophia; Wang, Lei; Liu, Yibin; Schubert, Maria‐Luisa; Wang, Sanmei; Neuber, Brigitte; Hückelhoven‐Krauss, Angela; Gern, Ulrike; Schmitt, Anita; Müller‐Tidow, Carsten; Dreger, Peter; Schmitt, Michael; Sellner, Leopold

Year: 2020

Venue: International Journal of Cancer

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Paper Immunotherapy in lymphoma

Ansell, Stephen M.; Caligaris‐Cappio, Federico; Maloney, David G. · 2017 · Hematological Oncology · DOI

Full title: Immunotherapy in lymphoma

Authors: Ansell, Stephen M.; Caligaris‐Cappio, Federico; Maloney, David G.

Year: 2017

Venue: Hematological Oncology

DOI: https://doi.org/10.1002/hon.2408

Paper Clinical chimeric antigen receptor‐T cell therapy: a new and promising treatment modality for glioblastoma

Brown, Michael P.; Ebert, Lisa M.; Gargett, Tessa · 2019 · Clinical & Translational Immunology · DOI

Full title: Clinical chimeric antigen receptor‐T cell therapy: a new and promising treatment modality for glioblastoma

Authors: Brown, Michael P.; Ebert, Lisa M.; Gargett, Tessa

Year: 2019

Venue: Clinical & Translational Immunology

DOI: https://doi.org/10.1002/cti2.1050

Paper Roles of IL-2 in bridging adaptive and innate immunity, and as a tool for cellular immunotherapy

Bendíčková, Kamila; Frič, Jan · 2020 · Journal of Leukocyte Biology · DOI

Full title: Roles of IL-2 in bridging adaptive and innate immunity, and as a tool for cellular immunotherapy

Authors: Bendíčková, Kamila; Frič, Jan

Year: 2020

Venue: Journal of Leukocyte Biology

DOI: https://doi.org/10.1002/jlb.5mir0420-055r

Paper CAR T cell therapy in advanced B‐ALL with heavy disease burden

Kaiting Tang; Zhuojun Ling; Jing Pan et al. · 2022 · Immunomedicine · DOI

Full title: CAR T cell therapy in advanced B‐ALL with heavy disease burden

Authors: Kaiting Tang; Zhuojun Ling; Jing Pan; He Huang

Year: 2022

Venue: Immunomedicine

DOI: https://doi.org/10.1002/imed.1037

Paper Synergistic effect and molecular mechanism of PVA and UM171 in ex vivo expansion of primitive hematopoietic stem cells

Yan Ren; Yanni Cui; Jingyi Feng et al. · 2023 · Journal of Cellular Biochemistry · DOI

Full title: Synergistic effect and molecular mechanism of PVA and UM171 in ex vivo expansion of primitive hematopoietic stem cells

Authors: Yan Ren; Yanni Cui; Jingyi Feng; Yanhong Tan; F. Ren; Yaofang Zhang; Hongwei Wang

Year: 2023

Venue: Journal of Cellular Biochemistry

DOI: https://doi.org/10.1002/jcb.30505

Paper Drug target validation in primary human natural killer cells using CRISPR RNP

Rautela, Jai; Surgenor, Elliot; Huntington, Nicholas D. · 2020 · Journal of Leukocyte Biology · DOI

Full title: Drug target validation in primary human natural killer cells using CRISPR RNP

Authors: Rautela, Jai; Surgenor, Elliot; Huntington, Nicholas D.

Year: 2020

Venue: Journal of Leukocyte Biology

DOI: https://doi.org/10.1002/jlb.2ma0620-074r

Paper CAR T cells: Building on the CD19 paradigm

Levin, Anat Globerson; Rivière, Isabelle; Eshhar, Zelig et al. · 2021 · European Journal of Immunology · DOI

Full title: CAR T cells: Building on the CD19 paradigm

Authors: Levin, Anat Globerson; Rivière, Isabelle; Eshhar, Zelig; Sadelain, Michel

Year: 2021

Venue: European Journal of Immunology

DOI: https://doi.org/10.1002/eji.202049064

Paper Idelalisib for optimized CD19‐specific chimeric antigen receptor T cells in chronic lymphocytic leukemia patients

Stock, Sophia; Übelhart, Rudolf; Schubert, Maria‐Luisa et al. · 2019 · International Journal of Cancer · DOI

Full title: Idelalisib for optimized CD19‐specific chimeric antigen receptor T cells in chronic lymphocytic leukemia patients

Authors: Stock, Sophia; Übelhart, Rudolf; Schubert, Maria‐Luisa; Fan, Fuli; He, Bailin; Hoffmann, Jean‐Marc; Wang, Lei; Wang, Sanmei; Gong, Wenjie; Neuber, Brigitte; Hückelhoven‐Krauss, Angela; Gern, Ulrike; Christ, Christiane; Hexel, Monika; Schmitt, Anita; Schmidt, Patrick; Krauß, Jürgen; Jäger, Dirk; Müller‐Tidow, Carsten; Dreger, Peter; Schmitt, Michael; Sellner, Leopold

Year: 2019

Venue: International Journal of Cancer

DOI: https://doi.org/10.1002/ijc.32201

Paper CAR‐NK cells from engineered pluripotent stem cells: Off‐the‐shelf therapeutics for all patients

Shijiang Lu; Q. Feng · 2021 · Stem Cells Translational Medicine · DOI

Full title: CAR‐NK cells from engineered pluripotent stem cells: Off‐the‐shelf therapeutics for all patients

Authors: Shijiang Lu; Q. Feng

Year: 2021

Venue: Stem Cells Translational Medicine

DOI: https://doi.org/10.1002/sctm.21-0135

Paper Antigen-specific stimulation and expansion of CAR-T cells using membrane vesicles as target cell surrogates

V. Ukrainskaya; Y. Rubtsov; D. Pershin et al. · 2021 · bioRxiv · DOI

Full title: Antigen-specific stimulation and expansion of CAR-T cells using membrane vesicles as target cell surrogates

Year: 2021

Venue: bioRxiv

DOI: https://doi.org/10.1101/2021.03.18.435976

Paper CAR-T Cell Expansion in a Xuri Cell Expansion System W25.

Smith, Trevor A · 2020 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: CAR-T Cell Expansion in a Xuri Cell Expansion System W25.

Authors: Smith, Trevor A

Year: 2020

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-0716-0146-4_11

Paper Generation of Redirected Engineered Human Chimeric Antigen Receptor (CAR) T Cells.

M. Bunse; U. Höpken · 2022 · Methods in molecular biology · DOI

Full title: Generation of Redirected Engineered Human Chimeric Antigen Receptor (CAR) T Cells.

Authors: M. Bunse; U. Höpken

Year: 2022

Venue: Methods in molecular biology

DOI: https://doi.org/10.1007/978-1-0716-2441-8_4

Paper Cellular determinants affecting the rate of cytokine in cultures of human hematopoietic cells.

P. Zandstra; A. Petzer; C. Eaves et al. · 1997 · Biotechnology and Bioengineering · DOI

Full title: Cellular determinants affecting the rate of cytokine in cultures of human hematopoietic cells.

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Paper Platforms for Clinical-Grade CAR-T Cell Expansion.

Mizukami, Amanda; Swiech, Kamilla · 2020 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Platforms for Clinical-Grade CAR-T Cell Expansion.

Authors: Mizukami, Amanda; Swiech, Kamilla

Year: 2020

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-0716-0146-4_10

Paper Induction of a central memory and stem cell memory phenotype in functionally active CD4+ and CD8+ CAR T cells produced in an automated good manufacturing practice system for the treatment of CD19+ acute lymphoblastic leukemia

Franziska Blaeschke; D. Stenger; Theresa Kaeuferle et al. · 2018 · Cancer Immunology and Immunotherapy · DOI

Full title: Induction of a central memory and stem cell memory phenotype in functionally active CD4+ and CD8+ CAR T cells produced in an automated good manufacturing practice system for the treatment of CD19+ acute lymphoblastic leukemia

Authors: Franziska Blaeschke; D. Stenger; Theresa Kaeuferle; Semjon Willier; R. Lotfi; A. Kaiser; M. Assenmacher; M. Döring; J. Feucht; T. Feuchtinger

Year: 2018

Venue: Cancer Immunology and Immunotherapy

DOI: https://doi.org/10.1007/s00262-018-2155-7

Paper Next-generation BCMA-targeted chimeric antigen receptor CARTemis-1: the impact of manufacturing procedure on CAR T-cell features

Belén Sierro-Martínez; V. Escamilla-Gómez; Laura Pérez-Ortega et al. · 2024 · Cellular Oncology · DOI

Full title: Next-generation BCMA-targeted chimeric antigen receptor CARTemis-1: the impact of manufacturing procedure on CAR T-cell features

Authors: Belén Sierro-Martínez; V. Escamilla-Gómez; Laura Pérez-Ortega; Beatriz Guijarro-Albaladejo; Paola Hernández-Díaz; María de la Rosa-Garrido; Maribel Lara-Chica; Alfonso Rodríguez-Gil; J. L. Reguera-Ortega; Luzalba Sanoja-Flores; Blanca Arribas-Arribas; M. Montiel-Aguilera; Gloria Carmona; Maria-Jose Robles; T. Caballero-Velázquez; Javier Briones; H. Einsele; M. Hudecek; J. Pérez-Simón; Estefanía García-Guerrero

Year: 2024

Venue: Cellular Oncology

DOI: https://doi.org/10.1007/s13402-024-00984-0

Paper Chimeric antigen receptor T (CAR-T) cells expanded with IL-7/IL-15 mediate superior antitumor effects

Zhou, Jianxia; Jin, Liyuan; Wang, Fuping et al. · 2019 · Protein & Cell · DOI

Full title: Chimeric antigen receptor T (CAR-T) cells expanded with IL-7/IL-15 mediate superior antitumor effects

Authors: Zhou, Jianxia; Jin, Liyuan; Wang, Fuping; Zhang, Yuan; Liu, Bing; Zhao, Tongbiao

Year: 2019

Venue: Protein & Cell

DOI: https://doi.org/10.1007/s13238-019-0643-y

Paper Memory T cells: strategies for optimizing tumor immunotherapy

Liu, Qingjun; Sun, Zhongjie; Chen, Ligong · 2020 · Protein & Cell · DOI

Full title: Memory T cells: strategies for optimizing tumor immunotherapy

Authors: Liu, Qingjun; Sun, Zhongjie; Chen, Ligong

Year: 2020

Venue: Protein & Cell

DOI: https://doi.org/10.1007/s13238-020-00707-9

Paper Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering

Hamilton, Jennifer; Tsuchida, Connor A.; Nguyen, David N. et al. · 2021 · Cell Reports · DOI

Full title: Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering

Authors: Hamilton, Jennifer; Tsuchida, Connor A.; Nguyen, David N.; Shy, Brian R.; McGarrigle, E. Riley; Espinoza, Cindy R. Sandoval; Carr, Daniel J.J.; Blaeschke, Franziska; Marson, Alexander; Doudna, Jennifer A.

Year: 2021

Venue: Cell Reports

DOI: https://doi.org/10.1016/j.celrep.2021.109207

Paper CAR-NK cells: A promising cellular immunotherapy for cancer

Xie, Guozhu; Dong, Han; Liang, Yong et al. · 2020 · EBioMedicine · DOI

Full title: CAR-NK cells: A promising cellular immunotherapy for cancer

Authors: Xie, Guozhu; Dong, Han; Liang, Yong; Ham, James Dongjoo; Rizwan, Romee; Chen, Jianzhu

Year: 2020

Venue: EBioMedicine

DOI: https://doi.org/10.1016/j.ebiom.2020.102975

Paper Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

Denk, Dominic; Petrocelli, Valentina; Conche, Claire et al. · 2022 · Immunity · DOI

Full title: Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

Authors: Denk, Dominic; Petrocelli, Valentina; Conche, Claire; Drachsler, Moritz; Ziegler, Paul K.; Braun, Angela; Kress, Alena; Nicolas, Adele M.; Mohs, Kathleen; Becker, Christoph; Neurath, Markus F.; Farin, Henner F.; Buchholz, Christian J.; Andreux, Pénélope A.; Rinsch, Chris; Greten, Florian R.

Year: 2022

Venue: Immunity

DOI: https://doi.org/10.1016/j.immuni.2022.09.014

Paper Targeting T cell metabolism for therapy

O’Sullivan, David; Pearce, Erika L. · 2015 · Trends in Immunology · DOI

Full title: Targeting T cell metabolism for therapy

Authors: O’Sullivan, David; Pearce, Erika L.

Year: 2015

Venue: Trends in Immunology

DOI: https://doi.org/10.1016/j.it.2014.12.004

Paper Manufacturing chimeric antigen receptor T cells: issues and challenges

Roddie, Claire; O’Reilly, Maeve; Dias, Juliana et al. · 2019 · Cytotherapy · DOI

Full title: Manufacturing chimeric antigen receptor T cells: issues and challenges

Authors: Roddie, Claire; O’Reilly, Maeve; Dias, Juliana; Vispute, Ketki; Lowdell, Mark W.

Year: 2019

Venue: Cytotherapy

DOI: https://doi.org/10.1016/j.jcyt.2018.11.009

Paper Different cytokine and stimulation conditions influence the expansion and immune phenotype of third-generation chimeric antigen receptor T cells specific for tumor antigen GD2.

Gargett, Tessa; Brown, Michael P · 2015 · Cytotherapy · DOI

Full title: Different cytokine and stimulation conditions influence the expansion and immune phenotype of third-generation chimeric antigen receptor T cells specific for tumor antigen GD2.

Authors: Gargett, Tessa; Brown, Michael P

Year: 2015

Venue: Cytotherapy

DOI: https://doi.org/10.1016/j.jcyt.2014.12.002

Paper Depletion of high-content CD14+ cells from apheresis products is critical for successful transduction and expansion of CAR T cells during large-scale cGMP manufacturing

Xiuyan Wang; Oriana Bórquez-Ojeda; J. Stefanski et al. · 2021 · Molecular Therapy: Methods & Clinical Development · DOI

Full title: Depletion of high-content CD14+ cells from apheresis products is critical for successful transduction and expansion of CAR T cells during large-scale cGMP manufacturing

Authors: Xiuyan Wang; Oriana Bórquez-Ojeda; J. Stefanski; Fang Du; Jinrong Qu; Jagrutiben Chaudhari; Keyur Thummar; Mingzhu Zhu; Ling-bo Shen; Melanie Hall; Paridhi Gautam; Yongzeng Wang; B. Senechal; D. Sikder; P. Adusumilli; R. Brentjens; K. Curran; M. Geyer; Sham Mailankhody; R. O'Cearbhaill; Jae H. Park; C. Sauter; S. Slovin; Eric L. Smith; I. Rivière

Year: 2021

Venue: Molecular Therapy: Methods & Clinical Development

DOI: https://doi.org/10.1016/j.omtm.2021.06.014

Paper Generating natural killer cells for adoptive transfer: expanding horizons

Kundu, Soumyadipta; Gurney, Mark E.; O’Dwyer, Michael · 2021 · Cytotherapy · DOI

Full title: Generating natural killer cells for adoptive transfer: expanding horizons

Authors: Kundu, Soumyadipta; Gurney, Mark E.; O’Dwyer, Michael

Year: 2021

Venue: Cytotherapy

DOI: https://doi.org/10.1016/j.jcyt.2020.12.002

Paper Abstract 2296: Inhibition of the PI3K/Akt pathway during CAR T cell production results in enhanced efficacy across multiple in vivo tumor models

Grande, Shannon; Perkins, Molly; Hamel, Amanda et al. · 2016 · Cancer Research · DOI

Full title: Abstract 2296: Inhibition of the PI3K/Akt pathway during CAR T cell production results in enhanced efficacy across multiple in vivo tumor models

Authors: Grande, Shannon; Perkins, Molly; Hamel, Amanda; Horton, Holly M.; Eng, Fay; Rhodes, Claire J.; Garrett, Tracy E.; Miller, Sara M.; Evans, John; Latimer, Howard J.; Horvath, Christopher; Kuczewski, Michael; Friedman, Kevin M.; Morgan, Richard A.

Year: 2016

Venue: Cancer Research

DOI: https://doi.org/10.1158/1538-7445.am2016-2296

Thesis Ceramic hollow fibre constructs for continuous perfusion and cell harvest from 3D hematopoietic organoids

Allenby, Mark C; Tahlawi, Asma; Morais, Jose CF et al. · 2018 · Imperial College London · DOI

Full title: Ceramic hollow fibre constructs for continuous perfusion and cell harvest from 3D hematopoietic organoids

Authors: Allenby, Mark C; Tahlawi, Asma; Morais, Jose CF; Li, Kang; Panoskaltsis, Nicki; Mantalaris, Athanasios

Year: 2018

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000429639200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Mathematical modelling and experimental validation for optimisation and control of mammalian cell culture systems

Quiroga Campano, Ana · 2019 · Imperial College London · DOI

Full title: Mathematical modelling and experimental validation for optimisation and control of mammalian cell culture systems

Authors: Quiroga Campano, Ana

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/68071

Thesis Constrained global sensitivity analysis for bioprocess design space identification

Kotidis, Pavlos; Demis, Panagiotis; Goey, Cher et al. · 2019 · Imperial College London · DOI

Full title: Constrained global sensitivity analysis for bioprocess design space identification

Authors: Kotidis, Pavlos; Demis, Panagiotis; Goey, Cher; Correa, Elisa; McIntosh, calum; Trepekli, Stefania; Shah, Nilay; Klymenko, Oleksiy; Kontoravdi, Kleio

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/66121

Thesis Strategic framework for parameterization of cell culture models

Kotidis, Pavlos; Kontoravdi, Cleo · 2019 · Imperial College London · DOI

Full title: Strategic framework for parameterization of cell culture models

Authors: Kotidis, Pavlos; Kontoravdi, Cleo

Year: 2019

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000464443100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Systematic review protocol: An assessment of the post-approval challenges of autologous CAR-T therapy delivery

Lam, Ching; Meinert, Edward; Halioua-Haubold, Celine et al. · 2019 · Imperial College London · DOI

Full title: Systematic review protocol: An assessment of the post-approval challenges of autologous CAR-T therapy delivery

Authors: Lam, Ching; Meinert, Edward; Halioua-Haubold, Celine; Carter, Alison; Yang, Aidong; Brindley, David; Cui, Zhanfeng

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/71523

Thesis DigiGlyc: A hybrid tool for reactive scheduling in cell culture systems

Kotidis, Pavlos; Pappas, Iosif; Avraamidou, Styliana et al. · 2021 · Imperial College London · DOI

Full title: DigiGlyc: A hybrid tool for reactive scheduling in cell culture systems

Authors: Kotidis, Pavlos; Pappas, Iosif; Avraamidou, Styliana; Pistikopoulos, Efstratios N; Kontoravdi, Cleo; Papathanasiou, Maria M

Year: 2021

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000697031900010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Decision support tools for regenerative medicine: systematic review

Lam, Ching; Meinert, Edward; Alturkistani, Abrar et al. · 2021 · Imperial College London · DOI

Full title: Decision support tools for regenerative medicine: systematic review

Authors: Lam, Ching; Meinert, Edward; Alturkistani, Abrar; Carter, Alison R; Karp, Jeffrey; Yang, Aidong; Brindley, David; Cui, Zhanfeng

Year: 2021

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454348200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Maximizing neotissue growth kinetics in a perfusion bioreactor: An in silico strategy using model reduction and Bayesian optimization

Mehrian, Mohammad; Guyot, Yann; Papantoniou, Ioannis et al. · 2021 · Imperial College London · DOI

Full title: Maximizing neotissue growth kinetics in a perfusion bioreactor: An in silico strategy using model reduction and Bayesian optimization

Authors: Mehrian, Mohammad; Guyot, Yann; Papantoniou, Ioannis; Olofsson, Simon; Sonnaert, Maarten; Misener, Ruth; Geris, Liesbet

Year: 2021

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000423672800010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Decision support tools for regenerative medicine: systematic review (Preprint)

Lam, Ching; Meinert, Edward; Alturkistani, Abrar et al. · 2021 · Imperial College London · DOI

Full title: Decision support tools for regenerative medicine: systematic review (Preprint)

Authors: Lam, Ching; Meinert, Edward; Alturkistani, Abrar; Carter, Alison R; Karp, Jeffrey; Yang, Aidong; Brindley, David; Cui, Zhanfeng

Year: 2021

Venue: Imperial College London

DOI: https://preprints.jmir.org/preprint/12448/submitted

Thesis Assessment of intermediate storage and distribution nodes in personalised medicine

Bernardi, Andrea; Sarkis, Miriam; Triantafyllou, Niki et al. · 2021 · Imperial College London · DOI

Full title: Assessment of intermediate storage and distribution nodes in personalised medicine

Authors: Bernardi, Andrea; Sarkis, Miriam; Triantafyllou, Niki; Lakelin, Matthew; Shah, Nilay; Papathanasiou, Maria M

Year: 2021

Venue: Imperial College London

DOI: https://www.sciencedirect.com/science/article/pii/S0098135421003604?via%3Dihub

Thesis Deciphering Mechanisms of CAR T Cell Differentiation and Efficacy with Multimodal Sequencing Analysis

Pan, Tony · 2025 · University of Chicago - Knowledge@UChicago · DOI

Full title: Deciphering Mechanisms of CAR T Cell Differentiation and Efficacy with Multimodal Sequencing Analysis

Authors: Pan, Tony

Year: 2025

Venue: University of Chicago - Knowledge@UChicago

DOI: https://knowledge.uchicago.edu/record/15530/files/Tony%20Pan%20DissertationOffice_ApprovalForm.pdf

Thesis Culture surface influence on T-cell phenotype and function

Hashimdeen, Shaikh Shimaz; Roemhild, Andy; Schmueck, Michael et al. · 2023 · Seoul National University · DOI

Full title: Culture surface influence on T-cell phenotype and function

Authors: Hashimdeen, Shaikh Shimaz; Roemhild, Andy; Schmueck, Michael; Kratz, Karl; Lendlein, Andreas; Kurtz, Andreas; Reinke, Petra

Year: 2023

Venue: Seoul National University

DOI: https://hdl.handle.net/10371/192322

Thesis A model‐based framework for parallel scale‐down fed‐batch cultivations in mini‐bioreactors for accelerated phenotyping

Anane, Emmanuel; García, Ángel Córcoles; Haby, Benjamin et al. · 2019 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: A model‐based framework for parallel scale‐down fed‐batch cultivations in mini‐bioreactors for accelerated phenotyping

Authors: Anane, Emmanuel; García, Ángel Córcoles; Haby, Benjamin; Hans, Sebastian; Krausch, Niels; Krewinkel, Manuel; Hauptmann, Peter; Neubauer, Peter; Cruz Bournazou, Mariano Nicolas; id_orcid0000-0001-9461-4414

Year: 2019

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/361027

Thesis Estudi d'estratègies de cultiu per a cèl·lules animals, basades en eines d'instrumentació i control

Gámez Montoya, Xavier · 2011 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Estudi d'estratègies de cultiu per a cèl·lules animals, basades en eines d'instrumentació i control

Authors: Gámez Montoya, Xavier

Year: 2011

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://www.tdx.cat/TDX-0125102-110641

Thesis Engineering next-generation chimeric antigen receptor-T cells: recent breakthroughs and remaining challenges in design and screening of novel chimeric antigen receptor variants

Mei, Anna; id_orcid0000-0001-7091-4471; Letscher, Kevin P. et al. · 2024 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: Engineering next-generation chimeric antigen receptor-T cells: recent breakthroughs and remaining challenges in design and screening of novel chimeric antigen receptor variants

Authors: Mei, Anna; id_orcid0000-0001-7091-4471; Letscher, Kevin P.; Reddy, Sai

Year: 2024

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/704470

Thesis An Immunocompetent Microphysiological System to Simultaneously Investigate Effects of Anti-Tumor Natural Killer Cells on Tumor and Cardiac Microtissues

Nguyen, Thi Phuong Oanh; id_orcid0000-0003-0192-2456; Misun, Patrick et al. · 2021 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: An Immunocompetent Microphysiological System to Simultaneously Investigate Effects of Anti-Tumor Natural Killer Cells on Tumor and Cardiac Microtissues

Authors: Nguyen, Thi Phuong Oanh; id_orcid0000-0003-0192-2456; Misun, Patrick; id_orcid0000-0003-0192-2456; Lohasz, Christian; id_orcid0000-0003-0192-2456; Lee, Jihyun; Wang, Weijia; Schroeder, Timm; id_orcid0000-0003-0192-2456; Hierlemann, Andreas; id_orcid0000-0003-0192-2456

Year: 2021

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/522031

Thesis Enhanced memory phenotype and proliferation dynamics of IL-15-armored CAR-T cells: implications for CD8+ T cell function and therapy

Kerbauy, Lucila Nassif · 2024 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Enhanced memory phenotype and proliferation dynamics of IL-15-armored CAR-T cells: implications for CD8+ T cell function and therapy

Authors: Kerbauy, Lucila Nassif

Year: 2024

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.1182/blood-2024-203671

Thesis Functional characterization and multi-factor analysis of exhaustion in chronic lymphocytic leukemia T cells

Lee, Joanne Haeun · 2021 · Columbia University · DOI

Full title: Functional characterization and multi-factor analysis of exhaustion in chronic lymphocytic leukemia T cells

Authors: Lee, Joanne Haeun

Year: 2021

Venue: Columbia University

DOI: https://doi.org/10.7916/d8-a1jg-8a50

Thesis Electrospun antibody-functionalized poly(dimethyl siloxane)-based meshes for improved T cell expansion

Dang, Alex Phu-Cuong · 2018 · Columbia University · DOI

Full title: Electrospun antibody-functionalized poly(dimethyl siloxane)-based meshes for improved T cell expansion

Authors: Dang, Alex Phu-Cuong

Year: 2018

Venue: Columbia University

DOI: https://doi.org/10.7916/D8KW6ZGD

Thesis Human T cell response to substrate rigidity for design of improved expansion platform

De Leo, Sarah Elizabeth · 2014 · Columbia University · DOI

Full title: Human T cell response to substrate rigidity for design of improved expansion platform

Authors: De Leo, Sarah Elizabeth

Year: 2014

Venue: Columbia University

DOI: https://doi.org/10.7916/D83F4N6H

Thesis Microfluidic and computational technologies to improve cell therapy manufacturing

Anandakumaran, Priya Nivashini · 2021 · Columbia University · DOI

Full title: Microfluidic and computational technologies to improve cell therapy manufacturing

Authors: Anandakumaran, Priya Nivashini

Year: 2021

Venue: Columbia University

DOI: https://doi.org/10.7916/d8-sth9-yc10

Thesis Actuated microcarrier sorting using piezoelectric element in a microfluidic channel

Rajab, Shukla Hyqel · 2022 · Nanyang Technological University (NTU) · DOI

Full title: Actuated microcarrier sorting using piezoelectric element in a microfluidic channel

Authors: Rajab, Shukla Hyqel

Year: 2022

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/158411

Thesis Effects of different serum supplements on PiggyBac CD19 Chimeric Antigen Receptor T cells

Sanyanusin, Mulita · 2022 · Chulalongkorn University · DOI

Full title: Effects of different serum supplements on PiggyBac CD19 Chimeric Antigen Receptor T cells

Authors: Sanyanusin, Mulita

Year: 2022

Venue: Chulalongkorn University

DOI: https://digital.car.chula.ac.th/chulaetd/5941

Thesis Manufacture of gene-modified human T-cells with a memory stem/central memory phenotype

Gomez-Eerland, Raquel; Nuijen, Bastiaan; Heemskerk, Bianca et al. · 2014 · Utrecht University · DOI

Full title: Manufacture of gene-modified human T-cells with a memory stem/central memory phenotype

Authors: Gomez-Eerland, Raquel; Nuijen, Bastiaan; Heemskerk, Bianca; van Rooij, Nienke; van den Berg, Joost H; Beijnen, Jos H; Uckert, Wolfgang; Kvistborg, Pia; Schumacher, Ton N; Haanen, John B A G; Jorritsma, Annelies

Year: 2014

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/308214

Thesis CSTF3-modified CAR-T cells: probing persistence, function and exhaustion in an in vitro model

Chia, Gladys Xin Yi · 2025 · Nanyang Technological University (NTU) · DOI

Full title: CSTF3-modified CAR-T cells: probing persistence, function and exhaustion in an in vitro model

Authors: Chia, Gladys Xin Yi

Year: 2025

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/200838

Thesis Three dimensional platforms for ex vivo hematopoietic cell bioprocesses

Cao, Xue · 2014 · Nanyang Technological University (NTU) · DOI

Full title: Three dimensional platforms for ex vivo hematopoietic cell bioprocesses

Authors: Cao, Xue

Year: 2014

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/59535

Thesis CAR-T Cells: A Systematic Review and Mixed Methods Analysis of the Clinical Trial Landscape

Pettitt, D; Arshad, Z; Smith, J et al. · 2025 · University of Basel - edoc Repository · DOI

Full title: CAR-T Cells: A Systematic Review and Mixed Methods Analysis of the Clinical Trial Landscape

Authors: Pettitt, D; Arshad, Z; Smith, J; Stanic, T; Holländer, G; Brindley, D

Year: 2025

Venue: University of Basel - edoc Repository

DOI: https://hdl.handle.net/20.500.14716/14719

Thesis Bioreactor systems in regenerative medicine: From basic science to biomanufacturing

Piccinini, E.; Wendt, D.; Martin, I. · 2025 · University of Basel - edoc Repository · DOI

Full title: Bioreactor systems in regenerative medicine: From basic science to biomanufacturing

Authors: Piccinini, E.; Wendt, D.; Martin, I.

Year: 2025

Venue: University of Basel - edoc Repository

DOI: https://hdl.handle.net/20.500.14716/43254

Thesis Precision Biomaterials for Modulating Regulatory T cells

Hadley, Pierce · 2024 · University of California, San Francisco (UCSF) · DOI

Full title: Precision Biomaterials for Modulating Regulatory T cells

Authors: Hadley, Pierce

Year: 2024

Venue: University of California, San Francisco (UCSF)

DOI: https://escholarship.org/uc/item/0s25c3jg

Thesis Oscillating perfusion of cell suspensions through three-dimensional scaffolds enhances cell seeding efficiency and uniformity

Wendt, D; Marsano, A; Jakob, M et al. · 2025 · University of Basel - edoc Repository · DOI

Full title: Oscillating perfusion of cell suspensions through three-dimensional scaffolds enhances cell seeding efficiency and uniformity

Authors: Wendt, D; Marsano, A; Jakob, M; Heberer, M; Martin, I

Year: 2025

Venue: University of Basel - edoc Repository

DOI: https://hdl.handle.net/20.500.14716/25106

Thesis Metabolomics-driven investigation of novel growth inhibitors in CHO cell bioprocessing

Johnston, Luke · 2025 · The University of Edinburgh · DOI

Full title: Metabolomics-driven investigation of novel growth inhibitors in CHO cell bioprocessing

Authors: Johnston, Luke

Year: 2025

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/44239

Thesis Expansion and genetic modification of human natural killer cells for adoptive immunotherapy of cancer

Tolga Sutlu (18650758) · 2012 · Karolinska Institutet · DOI

Full title: Expansion and genetic modification of human natural killer cells for adoptive immunotherapy of cancer

Authors: Tolga Sutlu (18650758)

Year: 2012

Venue: Karolinska Institutet

DOI: oai:figshare.com:article/26897227

Thesis In Vitro Cell Expansion and CTLA4 in Advanced T-Cell Therapies

Kaartinen, Tanja · 2017 · University of Helsinki (HELDA) · DOI

Full title: In Vitro Cell Expansion and CTLA4 in Advanced T-Cell Therapies

Authors: Kaartinen, Tanja

Year: 2017

Venue: University of Helsinki (HELDA)

DOI: http://hdl.handle.net/10138/180147

Thesis Fluid dynamics of a pilot-scale OrbShake bioreactor under different operating conditions

Zhu, Likuan; Zhao, Chunyang; Shiue, Angus et al. · 2021 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Fluid dynamics of a pilot-scale OrbShake bioreactor under different operating conditions

Authors: Zhu, Likuan; Zhao, Chunyang; Shiue, Angus; Jeng, Jyh-Cheng; Wurm, Maria J.; Raussin, Guillaume; Buerki, Cedric-Alain; Wurm, Florian M.

Year: 2021

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/183913

Thesis Small-scale bioreactor system for process development and optimization

Girard, P.; Jordan, M.; Tsao, M. et al. · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Small-scale bioreactor system for process development and optimization

Authors: Girard, P.; Jordan, M.; Tsao, M.; Wurm, F. M.

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7592

Thesis Developing efficient methods for ex vivo manufacturing of CAR T-cell therapeutics

Luostarinen, Annu · 2025 · University of Helsinki (HELDA) · DOI

Full title: Developing efficient methods for ex vivo manufacturing of CAR T-cell therapeutics

Authors: Luostarinen, Annu

Year: 2025

Venue: University of Helsinki (HELDA)

DOI: http://hdl.handle.net/10138/592189

Thesis Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors

Zhao, Yang · 2023 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors

Authors: Zhao, Yang

Year: 2023

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/200740

Thesis Use of Orbital Shaken Disposable Bioreactors for Mammalian Cell Cultures from the Milliliter-Scale to the 1,000-Liter Scale

Zhang, X; Stettler, M; Sanctis, DD et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Use of Orbital Shaken Disposable Bioreactors for Mammalian Cell Cultures from the Milliliter-Scale to the 1,000-Liter Scale

Authors: Zhang, X; Stettler, M; Sanctis, DD; Perrone, M; Parolini, N; Discacciati, M; Jesus, MD; Hacker, D; Quarteroni, A; Wurm, F

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41352

Thesis Orbitally shaken bioreactors for mammalian cell culture : engineering characterization and bioprocess scale-up

Zhang, Xiaowei · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Orbitally shaken bioreactors for mammalian cell culture : engineering characterization and bioprocess scale-up

Authors: Zhang, Xiaowei

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41858

Thesis Bioengineering Methods to Improve in vitro Adoptive Cell Therapy based on Tumor-Infiltrating Lymphocytes

Rivest, François Réal · 2020 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Bioengineering Methods to Improve in vitro Adoptive Cell Therapy based on Tumor-Infiltrating Lymphocytes

Authors: Rivest, François Réal

Year: 2020

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/164548

Thesis Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

Sun, Jie; Tang, Li · 2024 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

Authors: Sun, Jie; Tang, Li

Year: 2024

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/205012

Thesis Shaken helical track bioreactors: Providing oxygen to high-density cultures of mammalian cells at volumes up to 1000L by surface aeration with air

Zhang, X.; Stettler, M.; Reif, O. et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Shaken helical track bioreactors: Providing oxygen to high-density cultures of mammalian cells at volumes up to 1000L by surface aeration with air

Authors: Zhang, X.; Stettler, M.; Reif, O.; Kocourek, A.; Dejesus, M.; Hacker, D.; Wurm, F.

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/41411

Thesis Disposable 600-mL orbitally shaken bioreactor for mammalian cell cultivation in suspension

Monteil, Dominique T.; Tontodonati, Giulia; Ghimire, Saroj et al. · 2013 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Disposable 600-mL orbitally shaken bioreactor for mammalian cell cultivation in suspension

Authors: Monteil, Dominique T.; Tontodonati, Giulia; Ghimire, Saroj; Baldi, Lucia; Hacker, David L.; Bürki, Cédric A.; Wurm, Florian M.

Year: 2013

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/91783

Thesis Development of a predictive model for cell growth in shaken bioreactors as a function of the effects of temperature, oxygen transfer rate and seeding cell concentration

Broccard, Gilles · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Development of a predictive model for cell growth in shaken bioreactors as a function of the effects of temperature, oxygen transfer rate and seeding cell concentration

Authors: Broccard, Gilles

Year: 2009

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/44716

Thesis Production of immunoglobulin A in different reactor configurations

Stoll, T.; Perregaux, C.; Von Stockar, U. et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Production of immunoglobulin A in different reactor configurations

Authors: Stoll, T.; Perregaux, C.; Von Stockar, U.; Marison, I. W.

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/225985

Thesis Fluid dynamics of flow fields in a disposable 600-mL orbitally shaken bioreactor

Zhu, Likuan; Monteil, Dominique T.; Wang, Yukui et al. · 2018 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Fluid dynamics of flow fields in a disposable 600-mL orbitally shaken bioreactor

Authors: Zhu, Likuan; Monteil, Dominique T.; Wang, Yukui; Song, Boyan; Hacker, David L.; Wurm, Maria J.; Li, Xiaobin; Wang, Zhenlong; Wurm, Florian M.

Year: 2018

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/143980

Thesis Enhancing Engineered T Cell Persistence Mechanisms

Ravich, Jonas W · 2022 · Johns Hopkins University · DOI

Full title: Enhancing Engineered T Cell Persistence Mechanisms

Authors: Ravich, Jonas W

Year: 2022

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/67309

Thesis Turning CAR T therapy solid tumor infiltration into reality using synthetic velocity receptors

Johnston, Adrian · 2024 · Johns Hopkins University · DOI

Full title: Turning CAR T therapy solid tumor infiltration into reality using synthetic velocity receptors

Authors: Johnston, Adrian

Year: 2024

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/69504

Thesis MODULATING T CELL PHENOTYPE AND EXPANSION VIA CHANGING CO-STIMULTORY MOLECULE RATIO ON A FUNCTIONAL HYDROGEL

Kim, Sujin · 2025 · Johns Hopkins University · DOI

Full title: MODULATING T CELL PHENOTYPE AND EXPANSION VIA CHANGING CO-STIMULTORY MOLECULE RATIO ON A FUNCTIONAL HYDROGEL

Authors: Kim, Sujin

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70409

Thesis Engineering Molecular Platforms for the Development and Characterization of Cellular Therapeutics

Kizerwetter, Monika · 2025 · Johns Hopkins University · DOI

Full title: Engineering Molecular Platforms for the Development and Characterization of Cellular Therapeutics

Authors: Kizerwetter, Monika

Year: 2025

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/70616

Thesis Digitally enabled approaches for the scale up of mammalian cell bioreactors

Karimi Alavijeh, M; Baker, I; Lee, YY et al. · 2022 · University of Melbourne · DOI

Full title: Digitally enabled approaches for the scale up of mammalian cell bioreactors

Authors: Karimi Alavijeh, M; Baker, I; Lee, YY; Gras, SL

Year: 2022

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/321880

Thesis A bioreactor model of mouse tumor progression

Thouas, GA; Sheridan, J; Hourigan, K · 2021 · University of Melbourne · DOI

Full title: A bioreactor model of mouse tumor progression

Authors: Thouas, GA; Sheridan, J; Hourigan, K

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/268597

Thesis TSTEM-like CAR-T cells exhibit improved persistence and tumor control compared with conventional CAR-T cells in preclinical models

Meyran, D; Zhu, JJ; Butler, J et al. · 2023 · University of Melbourne · DOI

Full title: TSTEM-like CAR-T cells exhibit improved persistence and tumor control compared with conventional CAR-T cells in preclinical models

Authors: Meyran, D; Zhu, JJ; Butler, J; Tantalo, D; MacDonald, S; Nguyen, TN; Wang, M; Thio, N; D’Souza, C; Qin, VM; Slaney, C; Harrison, A; Sek, K; Petrone, P; Thia, K; Giuffrida, L; Scott, AM; Terry, RL; Tran, B; Desai, J; Prince, HM; Harrison, SJ; Beavis, PA; Kershaw, MH; Solomon, B; Ekert, PG; Trapani, JA; Darcy, PK; Neeson, PJ

Year: 2023

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/333451

Thesis Discovering Changes in Cell Stability Using Process Mining: A Case Study

Zhou, J; Armas-Cervantes, A; Bozorgi, ZD et al. · 2024 · University of Melbourne · DOI

Full title: Discovering Changes in Cell Stability Using Process Mining: A Case Study

Authors: Zhou, J; Armas-Cervantes, A; Bozorgi, ZD; Otte, E; Polyvyanyy, A

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/354056

Thesis Acoustic perfusion processes for hybridoma cultures: viability, cell cycle and metabolic analysis

Dalm, M.C.F. · 2007 · Wageningen University & Research · DOI

Full title: Acoustic perfusion processes for hybridoma cultures: viability, cell cycle and metabolic analysis

Authors: Dalm, M.C.F.

Year: 2007

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/acoustic-perfusion-processes-for-hybridoma-cultures-viability-cel

Thesis Feeding strategies enhance high cell density cultivation and protein expression in milliliter scale bioreactors

Georg Faust, Nils H. Janzen, Christoph Bendig, Lin Römer, Klaus Kaufmann, Dirk Weuster-Botz · 2014 · Technical University of Munich (TUM) · DOI

Full title: Feeding strategies enhance high cell density cultivation and protein expression in milliliter scale bioreactors

Authors: Georg Faust, Nils H. Janzen, Christoph Bendig, Lin Römer, Klaus Kaufmann, Dirk Weuster-Botz

Year: 2014

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1231846

Thesis Chimeric Antigen Receptor T Cell Therapy For The Treatment Of Hiv

Maldini, Colby · 2023 · University of Pennsylvania · DOI

Full title: Chimeric Antigen Receptor T Cell Therapy For The Treatment Of Hiv

Authors: Maldini, Colby

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/31293

Thesis Design of CAR-T Cell Manufacturing Process

Bartie, Liam J; Duhamel, Lauren R; Pan, Ruby C · 2023 · University of Pennsylvania · DOI

Full title: Design of CAR-T Cell Manufacturing Process

Authors: Bartie, Liam J; Duhamel, Lauren R; Pan, Ruby C

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/5946

Thesis REPROGRAMMING CAR T CELLS THROUGH ECTOPIC IL-9 SIGNALING TO ENHANCE EFFICACY AGAINST SOLID TUMORS

Castelli, Sofia · 2025 · University of Pennsylvania · DOI

Full title: REPROGRAMMING CAR T CELLS THROUGH ECTOPIC IL-9 SIGNALING TO ENHANCE EFFICACY AGAINST SOLID TUMORS

Authors: Castelli, Sofia

Year: 2025

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/61766

Thesis Enhanced Co-Stimulatory Signaling Improves Car T Cell Effector Responses In Chronic Lymphocytic Leukemia

Collins, Mckensie Alexis · 2023 · University of Pennsylvania · DOI

Full title: Enhanced Co-Stimulatory Signaling Improves Car T Cell Effector Responses In Chronic Lymphocytic Leukemia

Authors: Collins, Mckensie Alexis

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/31967

Thesis The effect of in vitro culture conditions on cell metabolism

Hartley, F · 2018 · University of Oxford - ORA · DOI

Full title: The effect of in vitro culture conditions on cell metabolism

Authors: Hartley, F

Year: 2018

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:160ef4ac-b599-49db-97dc-f820b5cdb61f

Thesis Targeted Engineering of Chimeric Antigen Receptor T-cells to Overcome Barriers for Therapeutic Success

Dimitri, Alexander · 2025 · University of Pennsylvania · DOI

Full title: Targeted Engineering of Chimeric Antigen Receptor T-cells to Overcome Barriers for Therapeutic Success

Authors: Dimitri, Alexander

Year: 2025

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/60899

Thesis T-Cell Manufacture for Treatment of Acute Lymphoblastic Leukemia

Pujari, Amit; Man, Chi-Wei; Park, Jinsang · 2023 · University of Pennsylvania · DOI

Full title: T-Cell Manufacture for Treatment of Acute Lymphoblastic Leukemia

Authors: Pujari, Amit; Man, Chi-Wei; Park, Jinsang

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/6032

Thesis GENETIC ENGINEERING STRATEGIES FOR EXPANDING THE THERAPEUTIC INDEX OF CHIMERIC ANTIGEN RECEPTOR CELLULAR IMMUNOTHERAPIES

Benton, Alexander · 2025 · University of Pennsylvania · DOI

Full title: GENETIC ENGINEERING STRATEGIES FOR EXPANDING THE THERAPEUTIC INDEX OF CHIMERIC ANTIGEN RECEPTOR CELLULAR IMMUNOTHERAPIES

Authors: Benton, Alexander

Year: 2025

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/60809

Thesis Mathematical modelling of cell growth in tissue engineering bioreactors

Chapman, L · 2015 · University of Oxford - ORA · DOI

Full title: Mathematical modelling of cell growth in tissue engineering bioreactors

Authors: Chapman, L

Year: 2015

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:7c9ee131-7d9b-4e5d-8534-04a059fbd039

Thesis Factors affecting the commercialization of cellular based therapeutics

Pettitt, D · 2018 · University of Oxford - ORA · DOI

Full title: Factors affecting the commercialization of cellular based therapeutics

Authors: Pettitt, D

Year: 2018

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:706415ea-dbea-4c3d-b3f6-4590621f33c5

Thesis A model-based approach to address the commercialisation challenges of autologous cell therapies

Lam, C · 2021 · University of Oxford - ORA · DOI

Full title: A model-based approach to address the commercialisation challenges of autologous cell therapies

Authors: Lam, C

Year: 2021

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:ecf91df5-9da6-4fc6-8c97-0ac0107a3d90

Thesis Hypothermic preservation of cellular products for advanced therapies

Nyland, RW · 2019 · University of Oxford - ORA · DOI

Full title: Hypothermic preservation of cellular products for advanced therapies

Authors: Nyland, RW

Year: 2019

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:d9e7c09d-8943-402a-9574-90384434d338

Thesis A multi-paradigm modelling framework for simulating biocomplexity

Kaul, H · 2013 · University of Oxford - ORA · DOI

Full title: A multi-paradigm modelling framework for simulating biocomplexity

Authors: Kaul, H

Year: 2013

Venue: University of Oxford - ORA

DOI: oai:ora.ox.ac.uk:uuid:a3e6913d-b4c1-49fd-88fb-7e7155de2e2f

Thesis Overcoming antigen loss in CAR T therapy with Vγ9Vδ2 CAR T-cells

Velasco Santiago, M.; Aehnlich, P.; Hulen, T. M. et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Overcoming antigen loss in CAR T therapy with Vγ9Vδ2 CAR T-cells

Authors: Velasco Santiago, M.; Aehnlich, P.; Hulen, T. M.; Jensen, K. M.; Holmen Olofsson, G.; Met, Özcan; id_orcid 0000-0002-3256-7592; thor Straten, P.

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/085434e7-4b75-4e2e-8e89-0c9b70968d9f

Thesis A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

Fan, Yuzhou; Jimenez Del Val, Ioscani; Müller, Christian et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

Authors: Fan, Yuzhou; Jimenez Del Val, Ioscani; Müller, Christian; Lund, Anne Mathilde; Wagtberg Sen, Jette; Rasmussen, Søren Kofoed; Kontoravdi, Cleo; Baycin-Hizal, Deniz; Betenbaugh, Michael J.; Weilguny, Dietmar; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/032ff7ec-9b40-4a61-8f15-f7c40fa6a14e

Thesis Advancing Cellular and Organ Model Metabolic Analysis with Hyperpolarized 13 C-NMR

Mathiassen, Thomas Benjamin Wareham · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Advancing Cellular and Organ Model Metabolic Analysis with Hyperpolarized 13 C-NMR

Authors: Mathiassen, Thomas Benjamin Wareham

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4cc0010f-5b76-42b9-b667-bc74dd4eb4d5

Thesis Deciphering Cytokine production in CHO cells by Integrating Cell Line Engineering and Omics Strategies

Scapin, Giulia; id_orcid 0000-0002-2978-9549 · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Deciphering Cytokine production in CHO cells by Integrating Cell Line Engineering and Omics Strategies

Authors: Scapin, Giulia; id_orcid 0000-0002-2978-9549

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4d3f74ae-375a-4103-9968-3b362af8aa22

Thesis Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Martínez-Monge, I.; Martínez, C.; Decker, M. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Authors: Martínez-Monge, I.; Martínez, C.; Decker, M.; Udugama, I. A.; Marín de Mas, I.; Gernaey, K. V.; id_orcid 0000-0002-0364-1773; Nielsen, L. K.

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3b1685d4-5ab9-4737-b414-d28fecf9b9eb

Thesis The cell density effect in animal cell-based bioprocessing:Questions, insights and perspectives

Lavado-García, Jesús; Pérez-Rubio, Pol; Cervera, Laura et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: The cell density effect in animal cell-based bioprocessing:Questions, insights and perspectives

Authors: Lavado-García, Jesús; Pérez-Rubio, Pol; Cervera, Laura; Gòdia, Francesc

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/59d319c9-b38b-40f6-a360-60ecc53c3457

Thesis Cell culture process dynamics and metabolic flux distributions using hybrid models

Kailasanathan, Rajiv; Sivaram, Abhishek; Mansouri, Seyed Soheil et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Cell culture process dynamics and metabolic flux distributions using hybrid models

Authors: Kailasanathan, Rajiv; Sivaram, Abhishek; Mansouri, Seyed Soheil; id_orcid 0000-0002-0924-4947

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/572e7d61-3351-4ced-b2f5-6b9e4ceab22f

Thesis Analyzing functional heterogeneity of effector cells for enhanced adoptive cell therapy applications

Kiel Rasmussen, AC C.; Hulen, T. M.; Petersen, D. L. et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Analyzing functional heterogeneity of effector cells for enhanced adoptive cell therapy applications

Authors: Kiel Rasmussen, AC C.; Hulen, T. M.; Petersen, D. L.; Jacobsen, M. J.; Mikkelsen, M. J.; Met, Özcan; id_orcid 0000-0002-3256-7592; Donia, M.; Chamberlain, C. A.; Mouritzen, P.

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/77668dcd-f455-4fd5-9743-9f689e740b65

Thesis Hybrid Modeling for On-Line Fermentation Optimization and Scale-Up:A Review

Albino, Mariana; Gargalo, Carina L.; id_orcid 0000-0002-8740-9591 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Hybrid Modeling for On-Line Fermentation Optimization and Scale-Up:A Review

Authors: Albino, Mariana; Gargalo, Carina L.; id_orcid 0000-0002-8740-9591; Nadal-Rey, Gisela; Albæk, Mads O.; Krühne, Ulrich; id_orcid 0000-0001-7774-7442; Gernaey, Krist V.; id_orcid 0000-0002-0364-1773

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/da2224b1-251a-47ea-abc0-1b523e3fb360

Thesis TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy

Tvingsholm, Siri Amanda; Frej, Marcus Svensson; Rafa, Vibeke Mindahl et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy

Authors: Tvingsholm, Siri Amanda; Frej, Marcus Svensson; Rafa, Vibeke Mindahl; Hansen, Ulla Kring; Ormhøj, Maria; Tyron, Alexander; Jensen, Agnete W.P.; Kadivar, Mohammad; Bentzen, Amalie Kai; id_orcid 0000-0002-5184-3054; Munk, Kamilla K.; Aasbjerg, Gitte N.; Ternander, Jeppe S.H.; Heeke, Christina; Tamhane, Tripti; Schmess, Christian; Funt, Samuel A.; Kjeldsen, Julie Westerlin; Kverneland, Anders Handrup; Met, Özcan; Draghi, Arianna; Jakobsen, Søren Nyboe; Donia, Marco; Marie Svane, Inge; Hadrup, Sine Reker; id_orcid 0000-0002-5937-4344

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/8cafced1-ec39-4889-9813-ceee5639dea8

Thesis Optimal Homogenization of Perfusion Flows in Microfluidic Bio-Reactors: A Numerical Study

Okkels, Fridolin; Dufva, Martin; id_orcid 0000-0001-5449-0189 et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: Optimal Homogenization of Perfusion Flows in Microfluidic Bio-Reactors: A Numerical Study

Authors: Okkels, Fridolin; Dufva, Martin; id_orcid 0000-0001-5449-0189; Bruus, Henrik

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/aaf561f9-d186-4c7c-979a-e74a2206828f

Thesis Glycolysis inhibition affects proliferation and cytotoxicity of Vγ9Vδ2 T cells expanded for adoptive cell therapy

Aehnlich, Pia; Santiago, Marta Velasco; Dam, Søren Helweg et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Glycolysis inhibition affects proliferation and cytotoxicity of Vγ9Vδ2 T cells expanded for adoptive cell therapy

Authors: Aehnlich, Pia; Santiago, Marta Velasco; Dam, Søren Helweg; Saló, Sara Fresnillo; Rahbech, Anne; Olsen, Lars Rønn; id_orcid 0000-0002-6725-7850; thor Straten, Per; Desler, Claus; Holmen Olofsson, Gitte

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b50515f5-05ad-4ce8-aefc-0af61ef70f0b

Thesis Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Martínez-Monge, I.; Martínez, C.; Decker, M. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Authors: Martínez-Monge, I.; Martínez, C.; Decker, M.; Udugama, I. A.; Marín de Mas, I.; Gernaey, K. V.; id_orcid 0000-0002-0364-1773; Nielsen, L. K.

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/3b1685d4-5ab9-4737-b414-d28fecf9b9eb

Thesis A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

Fan, Yuzhou; Jimenez Del Val, Ioscani; Müller, Christian et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/032ff7ec-9b40-4a61-8f15-f7c40fa6a14e

Thesis Novel technologies for tracking and engineering of CAR T cells

Friis, Rasmus Ulslev Wegener · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Novel technologies for tracking and engineering of CAR T cells

Authors: Friis, Rasmus Ulslev Wegener

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/28177a51-a23b-4693-8828-9d39319304a6

Thesis Overcoming antigen loss in CAR T therapy with Vγ9Vδ2 CAR T-cells

Velasco Santiago, M.; Aehnlich, P.; Hulen, T. M. et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Overcoming antigen loss in CAR T therapy with Vγ9Vδ2 CAR T-cells

Authors: Velasco Santiago, M.; Aehnlich, P.; Hulen, T. M.; Jensen, K. M.; Holmen Olofsson, G.; Met, Özcan; id_orcid 0000-0002-3256-7592; thor Straten, P.

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/085434e7-4b75-4e2e-8e89-0c9b70968d9f

Thesis Model Predictive Control of dissolved oxygen level in an intermittent fed-batch process – Simulation & Application

Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Model Predictive Control of dissolved oxygen level in an intermittent fed-batch process – Simulation & Application

Authors: Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235; Kager, Julian; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/fe55fd04-e378-4860-b304-b314688d1774

Thesis Advancing Cellular and Organ Model Metabolic Analysis with Hyperpolarized 13 C-NMR

Mathiassen, Thomas Benjamin Wareham · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Advancing Cellular and Organ Model Metabolic Analysis with Hyperpolarized 13 C-NMR

Authors: Mathiassen, Thomas Benjamin Wareham

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4cc0010f-5b76-42b9-b667-bc74dd4eb4d5

Thesis Bioreactor design and optimization – a future perspective

Gernaey, Krist; id_orcid 0000-0002-0364-1773 · 2011 · Technical University of Denmark (DTU) · DOI

Full title: Bioreactor design and optimization – a future perspective

Authors: Gernaey, Krist; id_orcid 0000-0002-0364-1773

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/547a2703-06bf-4138-befc-462716cda987

Thesis The cell density effect in animal cell-based bioprocessing:Questions, insights and perspectives

Lavado-García, Jesús; Pérez-Rubio, Pol; Cervera, Laura et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: The cell density effect in animal cell-based bioprocessing:Questions, insights and perspectives

Authors: Lavado-García, Jesús; Pérez-Rubio, Pol; Cervera, Laura; Gòdia, Francesc

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/59d319c9-b38b-40f6-a360-60ecc53c3457

Thesis Cell culture process dynamics and metabolic flux distributions using hybrid models

Kailasanathan, Rajiv; Sivaram, Abhishek; Mansouri, Seyed Soheil et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Cell culture process dynamics and metabolic flux distributions using hybrid models

Authors: Kailasanathan, Rajiv; Sivaram, Abhishek; Mansouri, Seyed Soheil; id_orcid 0000-0002-0924-4947

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/572e7d61-3351-4ced-b2f5-6b9e4ceab22f

Thesis TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy

Tvingsholm, Siri Amanda; Frej, Marcus Svensson; Rafa, Vibeke Mindahl et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/8cafced1-ec39-4889-9813-ceee5639dea8

Thesis Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

Fan, Yuzhou; Jimenez Del Val, Ioscani; Müller, Christian et al. · 2015 · Technical University of Denmark (DTU) · DOI

Full title: Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

Authors: Fan, Yuzhou; Jimenez Del Val, Ioscani; Müller, Christian; Wagtberg Sen, Jette; Rasmussen, Søren Kofoed; Kontoravdi, Cleo; Weilguny, Dietmar; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808

Year: 2015

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7390e534-3558-4a15-a8c1-359cc5555270

Thesis Perfusion-based three dimensional (3D) tissue engineering platform with integrated bioimpedance sensing

Muhammad, Haseena Bashir; Canali, Chiara; Heiskanen, Arto et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: Perfusion-based three dimensional (3D) tissue engineering platform with integrated bioimpedance sensing

Authors: Muhammad, Haseena Bashir; Canali, Chiara; Heiskanen, Arto; id_orcid 0000-0002-7124-8420; Hemmingsen, Mette; Wolff, Anders; id_orcid 0000-0001-9596-1215; Dufva, Martin; id_orcid 0000-0001-5449-0189; Emnéus, Jenny; id_orcid 0000-0002-8061-201X

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7cfaa3b0-b24e-42e4-85e8-f9f0157235d3

Thesis Analyzing functional heterogeneity of effector cells for enhanced adoptive cell therapy applications

Kiel Rasmussen, AC C.; Hulen, T. M.; Petersen, D. L. et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Analyzing functional heterogeneity of effector cells for enhanced adoptive cell therapy applications

Authors: Kiel Rasmussen, AC C.; Hulen, T. M.; Petersen, D. L.; Jacobsen, M. J.; Mikkelsen, M. J.; Met, Özcan; id_orcid 0000-0002-3256-7592; Donia, M.; Chamberlain, C. A.; Mouritzen, P.

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/77668dcd-f455-4fd5-9743-9f689e740b65

Thesis Glycolysis inhibition affects proliferation and cytotoxicity of Vγ9Vδ2 T cells expanded for adoptive cell therapy

Aehnlich, Pia; Santiago, Marta Velasco; Dam, Søren Helweg et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Glycolysis inhibition affects proliferation and cytotoxicity of Vγ9Vδ2 T cells expanded for adoptive cell therapy

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b50515f5-05ad-4ce8-aefc-0af61ef70f0b

Thesis A novel scale-down mimic of perfusion cell culture using sedimentation in an automated microbioreactor (SAM)

Kreye, Steffen; Stahn, Rainer; Nawrath, Karina et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: A novel scale-down mimic of perfusion cell culture using sedimentation in an automated microbioreactor (SAM)

Authors: Kreye, Steffen; Stahn, Rainer; Nawrath, Karina; Goralczyk, Vicky; Zoro, Barney; Goletz, Steffen; id_orcid 0000-0003-1463-5448

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a5da5e52-b2e6-4e1c-b721-f6263e866c5c

Thesis Functional stimulation of CAR T cells with artificial antigen presenting scaffolds

Ramanathan, Keerthana; id_orcid 0000-0001-7245-9169 · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Functional stimulation of CAR T cells with artificial antigen presenting scaffolds

Authors: Ramanathan, Keerthana; id_orcid 0000-0001-7245-9169

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/957ce041-3e32-4e88-86ad-b5616697083a

Thesis Optimal Homogenization of Perfusion Flows in Microfluidic Bio-Reactors: A Numerical Study

Okkels, Fridolin; Dufva, Martin; id_orcid 0000-0001-5449-0189 et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: Optimal Homogenization of Perfusion Flows in Microfluidic Bio-Reactors: A Numerical Study

Authors: Okkels, Fridolin; Dufva, Martin; id_orcid 0000-0001-5449-0189; Bruus, Henrik

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/aaf561f9-d186-4c7c-979a-e74a2206828f

Thesis Microfluidic bioreactors for culture of non-adherent cells

Shah, Pranjul Jaykumar; Vedarethinam, Indumathi; Kwasny, Dorota et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: Microfluidic bioreactors for culture of non-adherent cells

Authors: Shah, Pranjul Jaykumar; Vedarethinam, Indumathi; Kwasny, Dorota; Andresen, Lars; Dimaki, Maria; id_orcid 0000-0001-5037-2388; Skov, Søren; Svendsen, Winnie Edith; id_orcid 0000-0002-9197-6505

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d98d3698-cb04-4c2c-b079-12c9d6dd5288

Thesis Hybrid Modeling for On-Line Fermentation Optimization and Scale-Up:A Review

Albino, Mariana; Gargalo, Carina L.; id_orcid 0000-0002-8740-9591 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Hybrid Modeling for On-Line Fermentation Optimization and Scale-Up:A Review

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/da2224b1-251a-47ea-abc0-1b523e3fb360

Thesis Elongated T cell expansion by utilizing IL7 and IL15 leads to increased T cell yield while preserving Tcm/Tscm characteristics feasible for adoptive T cell therapy

Heimann, Andreas · 2021 · Freie Universität Berlin (Refubium) · DOI

Full title: Elongated T cell expansion by utilizing IL7 and IL15 leads to increased T cell yield while preserving Tcm/Tscm characteristics feasible for adoptive T cell therapy

Authors: Heimann, Andreas

Year: 2021

Venue: Freie Universität Berlin (Refubium)

DOI: https://refubium.fu-berlin.de/handle/fub188/29460

Thesis Alginate Core-Shell Scaffolds for CAR T cell Manufacturing

Mousavi Karimi, Zahra · 2022 · Georgia Institute of Technology · DOI

Full title: Alginate Core-Shell Scaffolds for CAR T cell Manufacturing

Authors: Mousavi Karimi, Zahra

Year: 2022

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/66251

Thesis The Dynamic Sampling Platform (DSP) for Real-time Bioreactor Monitoring

Chilmonczyk, Mason A. · 2021 · Georgia Institute of Technology · DOI

Full title: The Dynamic Sampling Platform (DSP) for Real-time Bioreactor Monitoring

Authors: Chilmonczyk, Mason A.

Year: 2021

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/64969

Thesis A Streamlined Multivariate Analysis Platform for Optimizing Mammalian Cell Culture and Biologics Production

Mingee, Andrew Nicholas · 2021 · Georgia Institute of Technology · DOI

Full title: A Streamlined Multivariate Analysis Platform for Optimizing Mammalian Cell Culture and Biologics Production

Authors: Mingee, Andrew Nicholas

Year: 2021

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/65145

Thesis Thin film, wireless, flexible sensing system for real-time cell-culture monitoring

Lodhi, Isha · 2020 · Georgia Institute of Technology · DOI

Full title: Thin film, wireless, flexible sensing system for real-time cell-culture monitoring

Authors: Lodhi, Isha

Year: 2020

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/63568

Thesis Simulation-Based Decision Support System for Cell Therapy Manufacturing and Supply Chain

Liu, Yi · 2021 · Georgia Institute of Technology · DOI

Full title: Simulation-Based Decision Support System for Cell Therapy Manufacturing and Supply Chain

Authors: Liu, Yi

Year: 2021

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/65014

Thesis Differentiation and Proliferation of Therapeutic T cells from umbilical cord blood derived cells

Holzworth, Peyton · 2022 · Georgia Institute of Technology · DOI

Full title: Differentiation and Proliferation of Therapeutic T cells from umbilical cord blood derived cells

Authors: Holzworth, Peyton

Year: 2022

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/66760

Thesis Engineering genetic thermal switches for remote control of therapeutic T cells

Sun, Lee-Kai · 2021 · Georgia Institute of Technology · DOI

Full title: Engineering genetic thermal switches for remote control of therapeutic T cells

Authors: Sun, Lee-Kai

Year: 2021

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/64834

Thesis The use of biosensors in control of fed-batch processes - Opportunities and limitations

Renneberg, R.; Barford, JP; Tse, SMA · 1998 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: The use of biosensors in control of fed-batch processes - Opportunities and limitations

Authors: Renneberg, R.; Barford, JP; Tse, SMA

Year: 1998

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-44080

Thesis Process development and process analytical technology integration for cell therapy manufacturing

Wang, Bryan · 2025 · Georgia Institute of Technology · DOI

Full title: Process development and process analytical technology integration for cell therapy manufacturing

Authors: Wang, Bryan

Year: 2025

Venue: Georgia Institute of Technology

DOI: https://hdl.handle.net/1853/76777

Thesis Artificial intelligence and machine learning for smart bioprocesses

Khanal, Samir Kumar; Tarafdar, Ayon; You, Siming · 2023 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Artificial intelligence and machine learning for smart bioprocesses

Authors: Khanal, Samir Kumar; Tarafdar, Ayon; You, Siming

Year: 2023

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-151011

Thesis Optimizing T Cell Manufacturing and Quality Using Functionalized Degradable Microscaffolds

Dwarshuis, Nathan · 2023 · Georgia Institute of Technology · DOI

Full title: Optimizing T Cell Manufacturing and Quality Using Functionalized Degradable Microscaffolds

Authors: Dwarshuis, Nathan

Year: 2023

Venue: Georgia Institute of Technology

DOI: http://hdl.handle.net/1853/70024

Thesis Effect of Feed Rate on Growth Rate and Antibody Production in the Fed-batch Culture of Murine Hybridoma Cells

Jang, JD; Barford, JP · 2000 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Effect of Feed Rate on Growth Rate and Antibody Production in the Fed-batch Culture of Murine Hybridoma Cells

Authors: Jang, JD; Barford, JP

Year: 2000

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-24332

Thesis A microfluidic platform for in situ mass spectrometry of intracellular biomarkers

Culberson, Austin L. · 2024 · Georgia Institute of Technology · DOI

Full title: A microfluidic platform for in situ mass spectrometry of intracellular biomarkers

Authors: Culberson, Austin L.

Year: 2024

Venue: Georgia Institute of Technology

DOI: https://hdl.handle.net/1853/75072

Thesis Multivalent immunomodulators for CAR T cell manufacturing and T cell-engager immunotherapy

Uricoli, Biaggio · 2025 · Georgia Institute of Technology · DOI

Full title: Multivalent immunomodulators for CAR T cell manufacturing and T cell-engager immunotherapy

Authors: Uricoli, Biaggio

Year: 2025

Venue: Georgia Institute of Technology

DOI: https://hdl.handle.net/1853/77714

Thesis Digital Twin Design and Autonomous Control of Bioreactor Systems for Human Immune Cell Expansion

Kanwar, Bharat · 2024 · Georgia Institute of Technology · DOI

Full title: Digital Twin Design and Autonomous Control of Bioreactor Systems for Human Immune Cell Expansion

Authors: Kanwar, Bharat

Year: 2024

Venue: Georgia Institute of Technology

DOI: https://hdl.handle.net/1853/75727

Thesis A biomechanics-based delivery strategy to primary immune cells for generating cell therapy with multiple gene knockout

Yu, Tong · 2025 · Georgia Institute of Technology · DOI

Full title: A biomechanics-based delivery strategy to primary immune cells for generating cell therapy with multiple gene knockout

Authors: Yu, Tong

Year: 2025

Venue: Georgia Institute of Technology

DOI: https://hdl.handle.net/1853/77638

Thesis A comparison of different culture methods for hybridoma propagation and monoclonal antibody production

Barford, John Patrick; Marquis, Christopher Peter; Harbour, Colin et al. · 1990 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: A comparison of different culture methods for hybridoma propagation and monoclonal antibody production

Authors: Barford, John Patrick; Marquis, Christopher Peter; Harbour, Colin; Löw, K.S.

Year: 1990

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-68971

Thesis Engineering CAR-Mucosal-Associated Invariant T (MAIT) cells for cancer therapy

Qian, Yuxin · 2024 · Imperial College London · DOI

Full title: Engineering CAR-Mucosal-Associated Invariant T (MAIT) cells for cancer therapy

Authors: Qian, Yuxin

Year: 2024

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/112059

Thesis Improving Three-Dimensional (3D) Embryonic Stem Cell Bioprocess Design

Yeo, David Chen Loong · 2013 · Imperial College London · DOI

Full title: Improving Three-Dimensional (3D) Embryonic Stem Cell Bioprocess Design

Authors: Yeo, David Chen Loong

Year: 2013

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/10678

Thesis Exploring the cellular response to acute mechanical force for intracellular delivery and cell therapy applications

McCandless, Megan · 2025 · Imperial College London · DOI

Full title: Exploring the cellular response to acute mechanical force for intracellular delivery and cell therapy applications

Authors: McCandless, Megan

Year: 2025

Venue: Imperial College London

DOI: https://hdl.handle.net/10044/1/125085

Thesis Systematic development of predictive mathematical models for animal cell cultures

Kontoravdi, Cleo; Pistikopoulos, Efstratios N; Mantalaris, Athanasios · 2014 · Imperial College London · DOI

Full title: Systematic development of predictive mathematical models for animal cell cultures

Authors: Kontoravdi, Cleo; Pistikopoulos, Efstratios N; Mantalaris, Athanasios

Year: 2014

Venue: Imperial College London

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000279658700003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Thesis Towards advanced bioprocess optimization: a multiscale modelling approach

Monteiro, Mariana; Fadda, Sarah; Kontoravdi, Kleio · 2023 · Imperial College London · DOI

Full title: Towards advanced bioprocess optimization: a multiscale modelling approach

Authors: Monteiro, Mariana; Fadda, Sarah; Kontoravdi, Kleio

Year: 2023

Venue: Imperial College London

DOI: https://www.sciencedirect.com/science/article/pii/S2001037023002362

Thesis Uncertainty quantification for gene delivery methods: a roadmap for pDNA manufacturing from phase I clinical trials to commercialization

Triantafyllou, Niki; Sarkis, Miriam; Krassakopoulou, Aikaterina et al. · 2024 · Imperial College London · DOI

Full title: Uncertainty quantification for gene delivery methods: a roadmap for pDNA manufacturing from phase I clinical trials to commercialization

Authors: Triantafyllou, Niki; Sarkis, Miriam; Krassakopoulou, Aikaterina; Shah, Nilay; Papathanasiou, Maria M; Kontoravdi, Cleo

Year: 2024

Venue: Imperial College London

DOI: http://dx.doi.org/10.1002/biot.202300103

Thesis Smart CAR-T Nanosymbionts: archetypes and proto-models

Baena, Juan C; Victoria, Juan Sebastián; Toro-Pedroza, Alejandro et al. · 2025 · Imperial College London · DOI

Full title: Smart CAR-T Nanosymbionts: archetypes and proto-models

Authors: Baena, Juan C; Victoria, Juan Sebastián; Toro-Pedroza, Alejandro; Aragón, Cristian C; Ortiz-Guzman, Joshua; Garcia-Robledo, Juan Esteban; Torres, David; Rios-Serna, Lady J; Albornoz, Ludwig; Rosales, Joaquin D; Cañas, Carlos A; Adolfo Cruz-Suarez, Gustavo; Osorio, Felipe Ocampo; Fleitas, Tania; Laponogov, Ivan; Loukanov, Alexandre; Veselkov, Kirill

Year: 2025

Venue: Imperial College London

DOI: https://hdl.handle.net/10044/1/123120

Thesis Chimeric Antigen Receptor T cells for Invasive Fungal Infections using a Novel Gene Modification Strategy

Sutrave, Gaurav · 2021 · University of Sydney · DOI

Full title: Chimeric Antigen Receptor T cells for Invasive Fungal Infections using a Novel Gene Modification Strategy

Authors: Sutrave, Gaurav

Year: 2021

Venue: University of Sydney

DOI: https://hdl.handle.net/2123/26933

Thesis Real-time online in situ monitoring and statistical design strategies for haematopoietic stem cell bioprocessing

Lim, Mayasari; Lim, Mayasari · 2010 · Imperial College London · DOI

Full title: Real-time online in situ monitoring and statistical design strategies for haematopoietic stem cell bioprocessing

Authors: Lim, Mayasari; Lim, Mayasari

Year: 2010

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/4408

Thesis In Situ Monitoring of Intracellular Glucose and Glutamine in CHO Cell Culture

Behjousiar, A; Kontoravdi, C; Polizzi, KM · 2014 · Imperial College London · DOI

Full title: In Situ Monitoring of Intracellular Glucose and Glutamine in CHO Cell Culture

Authors: Behjousiar, A; Kontoravdi, C; Polizzi, KM

Year: 2014

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/14483

Thesis From titer to quality: exploring reinforcement learning for bioprocess control in silico

Monteiro, Mariana; Flevaris, Konstantinos; Kontoravdi, Cleo · 2025 · Imperial College London · DOI

Full title: From titer to quality: exploring reinforcement learning for bioprocess control in silico

Authors: Monteiro, Mariana; Flevaris, Konstantinos; Kontoravdi, Cleo

Year: 2025

Venue: Imperial College London

DOI: https://hdl.handle.net/10044/1/124760

Thesis Stem Cell Biomanufacturing under Uncertainty: A Case Study in Optimizing Red Blood Cell Production

Misener, R; Allenby; Fuentes-Gari, M et al. · 2017 · Imperial College London · DOI

Full title: Stem Cell Biomanufacturing under Uncertainty: A Case Study in Optimizing Red Blood Cell Production

Authors: Misener, R; Allenby; Fuentes-Gari, M; Gupta, K; Wiggins, T; Panoskaltsis; Pistikopoulos; Mantalaris

Year: 2017

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/53945

Thesis Apoptosis: A mammalian cell bioprocessing perspective

Grilo, Antonio L; Mantalaris, A · 2019 · Imperial College London · DOI

Full title: Apoptosis: A mammalian cell bioprocessing perspective

Authors: Grilo, Antonio L; Mantalaris, A

Year: 2019

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/67883

Patent us-2022112461-a1

· 2022

Full title: us-2022112461-a1

Year: 2022

Patent us-2022289815-a1

· 2022

Full title: us-2022289815-a1

Year: 2022

Patent us-2023136350-a1

· 2023

Full title: us-2023136350-a1

Year: 2023

Patent us-2017218337-a1

· 2017

Full title: us-2017218337-a1

Year: 2017

Patent us-2018133296-a1

· 2018

Full title: us-2018133296-a1

Year: 2018

Patent us-2018171294-a1

· 2018

Full title: us-2018171294-a1

Year: 2018

Patent us-2018320133-a1

· 2018

Full title: us-2018320133-a1

Year: 2018

Patent us-2019309250-a1

· 2019

Full title: us-2019309250-a1

Year: 2019

Patent us-2020095547-a1

· 2020

Full title: us-2020095547-a1

Year: 2020

Patent us-2021102165-a1

· 2021

Full title: us-2021102165-a1

Year: 2021

Patent us-2024117309-a1

· 2024

Full title: us-2024117309-a1

Year: 2024

Patent us-11149244-b2

· 2021

Full title: us-11149244-b2

Year: 2021

2. Data Extraction

0/953 extracted

Paper

The next frontier in immunotherapy: potential and challenges of CAR-macrophages

Li, Jing; Chen, Ping; Ma, Wenxue · 2024

Full title: The next frontier in immunotherapy: potential and challenges of CAR-macrophages

Authors: Li, Jing; Chen, Ping; Ma, Wenxue

DOI: https://doi.org/10.1186/s40164-024-00549-9

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Towards a commercial process for the manufacture of genetically modified T cells for therapy

Kaiser, A.; Assenmacher, Mario; Schröder, Bernd et al. · 2015

Full title: Towards a commercial process for the manufacture of genetically modified T cells for therapy

Authors: Kaiser, A.; Assenmacher, Mario; Schröder, Bernd; Meyer, Marku S; Orentas, Rimas J.; Bethke, Ulf; Dropulić, Boro

DOI: https://doi.org/10.1038/cgt.2014.78

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Yoon, Suk Ran; Kim, Tae‐Don; Choi, Inpyo · 2015

Full title: Understanding of molecular mechanisms in natural killer cell therapy

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DOI: https://doi.org/10.1038/emm.2014.114

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Full title: 4-1BB immunotherapy: advances and hurdles

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DOI: https://doi.org/10.1038/s12276-023-01136-4

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Culture expansion of CAR T cells results in aberrant DNA methylation that is associated with adverse clinical outcome

L. Salz; Alexander Seitz; D. Schäfer et al. · 2023

Full title: Culture expansion of CAR T cells results in aberrant DNA methylation that is associated with adverse clinical outcome

Authors: L. Salz; Alexander Seitz; D. Schäfer; Julia Franzen; T. Holzer; C. García-Prieto; I. Bürger; O. Hardt; M. Esteller; W. Wagner

DOI: https://doi.org/10.1038/s41375-023-01966-1

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Optimized T-cell receptor-mimic chimeric antigen receptor T cells directed toward the intracellular Wilms Tumor 1 antigen

Rafiq, Sarwish; Purdon, Terence J.; Daniyan, Anthony F. et al. · 2016

Full title: Optimized T-cell receptor-mimic chimeric antigen receptor T cells directed toward the intracellular Wilms Tumor 1 antigen

Authors: Rafiq, Sarwish; Purdon, Terence J.; Daniyan, Anthony F.; Koneru, Mythili; Dao, Tao; Liu, C; Scheinberg, David A.; Brentjens, Renier J.

DOI: https://doi.org/10.1038/leu.2016.373

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Phase 1 clinical trial of B-Cell Maturation Antigen (BCMA) NEX-T® Chimeric Antigen Receptor (CAR) T cell therapy CC-98633/BMS-986354 in participants with triple-class exposed multiple myeloma

G. Ravi; S. Richard; Shaji K. Kumar et al. · 2025

DOI: https://doi.org/10.1038/s41375-025-02518-5

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Full title: CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression

DOI: https://doi.org/10.1038/s41375-020-0792-2

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Signaling pathways in the regulation of cytokine release syndrome in human diseases and intervention therapy

Li, Xia; Shao, Mi; Zeng, Xiangjun et al. · 2021

Full title: Signaling pathways in the regulation of cytokine release syndrome in human diseases and intervention therapy

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DOI: https://doi.org/10.1038/s41392-021-00764-4

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Ma, Qizhi; He, Xia; Zhang, Benxia et al. · 2022

Full title: A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis

DOI: https://doi.org/10.1038/s41392-022-01198-2

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CAR T-cell therapy in multiple myeloma: more room for improvement

Teoh, Phaik Ju; Chng, Wee Joo · 2021

Full title: CAR T-cell therapy in multiple myeloma: more room for improvement

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DOI: https://doi.org/10.1038/s41408-021-00469-5

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Primary CD33-targeting CAR-NK cells for the treatment of acute myeloid leukemia

Albinger, Nawid; Pfeifer, Rita; Nitsche, Marcus et al. · 2022

Full title: Primary CD33-targeting CAR-NK cells for the treatment of acute myeloid leukemia

DOI: https://doi.org/10.1038/s41408-022-00660-2

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Zhang, Yinqiang; Li, Chenggong; Du, Mengyi et al. · 2023

Full title: Allogenic and autologous anti-CD7 CAR-T cell therapies in relapsed or refractory T-cell malignancies

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Yang, Junfang; He, Jiaping; Zhang, Xian et al. · 2022

Full title: Next-day manufacture of a novel anti-CD19 CAR-T therapy for B-cell acute lymphoblastic leukemia: first-in-human clinical study

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Novel CD19 chimeric antigen receptor T cells manufactured next-day for acute lymphoblastic leukemia

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Wang, Wenkang; Liu, Yang; He, Zhen et al. · 2024

Full title: Breakthrough of solid tumor treatment: CAR-NK immunotherapy

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D’Aloia, Maria Michela; Zizzari, Ilaria Grazia; Sacchetti, Benedetto et al. · 2018

Full title: CAR-T cells: the long and winding road to solid tumors

Authors: D’Aloia, Maria Michela; Zizzari, Ilaria Grazia; Sacchetti, Benedetto; Pierelli, Luca; Alimandi, Maurizio

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CAR-T cell therapy: current limitations and potential strategies

Sterner, Robert C.; Sterner, Rosalie M. · 2021

Full title: CAR-T cell therapy: current limitations and potential strategies

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DOI: https://doi.org/10.1038/s41408-021-00459-7

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Wei, Jianshu; Guo, Yelei; Wang, Yao et al. · 2020

Full title: Clinical development of CAR T cell therapy in China: 2020 update

Authors: Wei, Jianshu; Guo, Yelei; Wang, Yao; Wu, Zhiqiang; Bo, Jian; Zhang, Bin; Zhu, Jun; Han, Weidong

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Saravia, Jordy; Raynor, Jana; Chapman, Nicole M. et al. · 2020

Full title: Signaling networks in immunometabolism

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Xu, Yan; Xiang, Zheng; Alnaggar, Mohammed et al. · 2020

Full title: Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer

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Full title: Cancer immunotherapy with γδ T cells: many paths ahead of us

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Full title: Regulation of CD8+ T memory and exhaustion by the mTOR signals

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Zah, Eugenia; Nam, Eunwoo; Bhuvan, Vinya et al. · 2020

Full title: Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma

Authors: Zah, Eugenia; Nam, Eunwoo; Bhuvan, Vinya; Tran, Uyen; Ji, Brenda; Gosliner, Stanley B.; Wang, Xiuli; Brown, Christine E.; Chen, Yvonne Y.

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Full title: Driving cars to the clinic for solid tumors

Authors: Castellarin, Mauro; Watanabe, Keisuke; June, Carl H.; Kloss, Christopher C.; Posey, Avery D.

DOI: https://doi.org/10.1038/s41434-018-0007-x

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Synthetic cytokine receptors transmit biological signals using artificial ligands

Engelowski, Erika; Schneider, Artur; Franke, Manuel et al. · 2018

Full title: Synthetic cytokine receptors transmit biological signals using artificial ligands

DOI: https://doi.org/10.1038/s41467-018-04454-8

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Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic

Zhang, Xuqing; Luo, Mengyao; Dastagir, Shamael R. et al. · 2021

Full title: Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic

DOI: https://doi.org/10.1038/s41467-021-22898-3

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Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality

Sachdeva, Mohit; Busser, Brian W.; Temburni, Sonal et al. · 2019

Full title: Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality

DOI: https://doi.org/10.1038/s41467-019-13088-3

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CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation

Otano, Itziar; Azpilikueta, Arantza; Glez‐Vaz, Javier et al. · 2021

Full title: CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation

DOI: https://doi.org/10.1038/s41467-021-27613-w

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A long-acting interleukin-7, rhIL-7-hyFc, enhances CAR T cell expansion, persistence, and anti-tumor activity

Kim, Miriam; Jayasinghe, Reyka G.; Devenport, Jessica M. et al. · 2022

Full title: A long-acting interleukin-7, rhIL-7-hyFc, enhances CAR T cell expansion, persistence, and anti-tumor activity

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Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9

Liu, Lintao; Bi, Enguang; Ma, Xingzhe et al. · 2020

Full title: Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9

Authors: Liu, Lintao; Bi, Enguang; Ma, Xingzhe; Xiong, Wei; Qian, Jianfei; Ye, Lingqun; Pan, Su; Wang, Qiang; Xiao, Liuling; Yang, Maojie; Lu, Yong; Yi, Qing

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Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia

Sugita, Mayumi; Galetto, Román; Zong, Hongliang et al. · 2022

Full title: Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia

DOI: https://doi.org/10.1038/s41467-022-29668-9

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DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system

Trotman‐Grant, Ashton; Mohtashami, Mahmood; Casal, Joshua de Sousa et al. · 2021

Full title: DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system

DOI: https://doi.org/10.1038/s41467-021-25245-8

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Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma

Cichocki, Frank; Bjordahl, Ryan; Goodridge, Jodie P. et al. · 2022

Full title: Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma

DOI: https://doi.org/10.1038/s41467-022-35127-2

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The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer

Li, Nan; Quan, Alex; Li, Dan et al. · 2023

Full title: The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer

DOI: https://doi.org/10.1038/s41467-023-37616-4

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Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

Lee, Eric Hee Jun; Murad, John P.; Christian, Lea et al. · 2023

Full title: Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

DOI: https://doi.org/10.1038/s41467-023-40115-1

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Histone marks identify novel transcription factors that parse CAR-T subset-of-origin, clinical potential and expansion

S. Fiorenza; Y. Zheng; J. Purushe et al. · 2024

Full title: Histone marks identify novel transcription factors that parse CAR-T subset-of-origin, clinical potential and expansion

DOI: https://doi.org/10.1038/s41467-024-52503-2

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Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells

Ueda, Tatsuki; Shiina, Sara; Iriguchi, Shoichi et al. · 2022

Full title: Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells

DOI: https://doi.org/10.1038/s41551-022-00969-0

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IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity

Landoni, Elisa; Woodcock, Mark G.; Barragán, Gabriel A. et al. · 2024

Full title: IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity

DOI: https://doi.org/10.1038/s41467-023-44310-y

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Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma

Gyurdieva, Alexandra; Zajic, Stefan; Chang, Ya-Fang et al. · 2022

Full title: Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma

DOI: https://doi.org/10.1038/s41467-022-32491-x

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Enhancing CAR-T cell functionality in a patient-specific manner

David K. Y. Zhang; Kwasi Adu-Berchie; Siddharth Iyer et al. · 2023

Full title: Enhancing CAR-T cell functionality in a patient-specific manner

Authors: David K. Y. Zhang; Kwasi Adu-Berchie; Siddharth Iyer; Yutong Liu; Nicoletta Cieri; Joshua M. Brockman; D. Neuberg; Catherine J. Wu; D. Mooney

DOI: https://doi.org/10.1038/s41467-023-36126-7

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Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy

Tao Zheng; Keerthana Ramanathan; Maria Ormhøj et al. · 2025

Full title: Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy

DOI: https://doi.org/10.1101/2025.04.10.648181

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Potentiating adoptive cell therapy using synthetic IL-9 receptors

Kalbasi, Anusha; Siurala, Mikko; Su, Leon et al. · 2022

Full title: Potentiating adoptive cell therapy using synthetic IL-9 receptors

DOI: https://doi.org/10.1038/s41586-022-04801-2

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GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas

Majzner, Robbie G.; Ramakrishna, Sneha; Yeom, Kristen W. et al. · 2022

Full title: GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas

DOI: https://doi.org/10.1038/s41586-022-04489-4

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A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy

Quijano‐Rubio, Alfredo; Bhuiyan, M. Aladdin; Yang, Huilin et al. · 2022

Full title: A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy

DOI: https://doi.org/10.1038/s41587-022-01510-z

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Deconvolution of clinical variance in CAR-T cell pharmacology and response

Kirouac, Daniel C.; Zmurchok, Cole; Deyati, Avisek et al. · 2023

Full title: Deconvolution of clinical variance in CAR-T cell pharmacology and response

Authors: Kirouac, Daniel C.; Zmurchok, Cole; Deyati, Avisek; Sicherman, Jordan; Bond, Chris T.; Zandstra, Peter W.

DOI: https://doi.org/10.1038/s41587-023-01687-x

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CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial

Spiegel, Jay Y.; Patel, Shabnum; Muffly, Lori et al. · 2021

Full title: CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial

DOI: https://doi.org/10.1038/s41591-021-01436-0

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Tumor immune contexture is a determinant of anti-CD19 CAR T cell efficacy in large B cell lymphoma

Scholler, Nathalie; Perbost, Régis; Locke, Frederick L. et al. · 2022

Full title: Tumor immune contexture is a determinant of anti-CD19 CAR T cell efficacy in large B cell lymphoma

DOI: https://doi.org/10.1038/s41591-022-01916-x

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Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial

Brown, Christine E.; Hibbard, Jonathan; Alizadeh, Darya et al. · 2024

Full title: Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial

DOI: https://doi.org/10.1038/s41591-024-02875-1

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CLDN6-specific CAR-T cells plus amplifying RNA vaccine in relapsed or refractory solid tumors: the phase 1 BNT211-01 trial

Mackensen, Andréas; Haanen, John B.A.G.; Koenecke, Christian et al. · 2023

Full title: CLDN6-specific CAR-T cells plus amplifying RNA vaccine in relapsed or refractory solid tumors: the phase 1 BNT211-01 trial

DOI: https://doi.org/10.1038/s41591-023-02612-0

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Intracellular delivery of mRNA to human primary T cells with microfluidic vortex shedding

Jarrell, Justin A.; Twite, Amy A.; Lau, Katherine H. W. J. et al. · 2019

Full title: Intracellular delivery of mRNA to human primary T cells with microfluidic vortex shedding

Authors: Jarrell, Justin A.; Twite, Amy A.; Lau, Katherine H. W. J.; Kashani, Moein Navvab; Lievano, Adrian A.; Acevedo, Julyana; Priest, Craig; Nieva, Jorge J.; Gottlieb, David; Pawell, Ryan S.

DOI: https://doi.org/10.1038/s41598-019-40147-y

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Transgenic expression of IL-7 regulates CAR-T cell metabolism and enhances in vivo persistence against tumor cells

Li, Li; Li, Qing; Yan, Zi‐Xun et al. · 2022

Full title: Transgenic expression of IL-7 regulates CAR-T cell metabolism and enhances in vivo persistence against tumor cells

Authors: Li, Li; Li, Qing; Yan, Zi‐Xun; Sheng, Lingshuang; Fu, Di; Xu, Pengpeng; Wang, Li; Zhao, Weili

DOI: https://doi.org/10.1038/s41598-022-16616-2

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Manufacturing and preclinical validation of CAR T cells targeting ICAM-1 for advanced thyroid cancer therapy

Vedvyas, Yogindra; McCloskey, Jaclyn E.; Yang, Yanping et al. · 2019

Full title: Manufacturing and preclinical validation of CAR T cells targeting ICAM-1 for advanced thyroid cancer therapy

DOI: https://doi.org/10.1038/s41598-019-46938-7

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Comparison of two lab-scale protocols for enhanced mRNA-based CAR-T cell generation and functionality

Nadine von Auw; Robert Serfling; Reni Kitte et al. · 2023

Full title: Comparison of two lab-scale protocols for enhanced mRNA-based CAR-T cell generation and functionality

Authors: Nadine von Auw; Robert Serfling; Reni Kitte; N. Hilger; Chengkang Zhang; Clara Gebhardt; Anna Duenkel; Paul Franz; U. Koehl; Stephan Fricke; U. S. Tretbar

DOI: https://doi.org/10.1038/s41598-023-45197-x

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convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting

Landgraf, Kyle E.; Williams, Steven R.; Steiger, Daniel et al. · 2020

Full title: convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting

Authors: Landgraf, Kyle E.; Williams, Steven R.; Steiger, Daniel; Gebhart, Dana; Lok, Stephen; Martin, David W.; Roybal, Kole T.; Kim, Kaman Chan

DOI: https://doi.org/10.1038/s42003-020-1021-2

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Mapping real-time metabolic kinetics of expanded CAR T cells using hyperpolarized 13C-glucose and metabolomics

Thomas B. Wareham Mathiassen; M. R. Hansen; Magnus Karlsson et al. · 2025

Full title: Mapping real-time metabolic kinetics of expanded CAR T cells using hyperpolarized 13C-glucose and metabolomics

Authors: Thomas B. Wareham Mathiassen; M. R. Hansen; Magnus Karlsson; S. Hadrup; Maria Ormhøj; P. R. Jensen

DOI: https://doi.org/10.1038/s41598-025-24712-2

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In vitro encapsulation and expansion of T and CAR-T cells using 3D synthetic thermo-responsive matrices

Gaby D Lizana-Vasquez; Janet Mendez-Vega; D. Cappabianca et al. · 2024

Full title: In vitro encapsulation and expansion of T and CAR-T cells using 3D synthetic thermo-responsive matrices

Authors: Gaby D Lizana-Vasquez; Janet Mendez-Vega; D. Cappabianca; Krishanu Saha; M. Torres-Lugo

DOI: https://doi.org/10.1039/d4ra01968g

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Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response

Gnanaprakasam, JN Rashida; Kushwaha, Bhavana; Liu, Lingling et al. · 2023

Full title: Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response

DOI: https://doi.org/10.1038/s42255-023-00856-1

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Enhanced functionality of low-affinity CD19 CAR T-cells is associated with activation priming and a polyfunctional cytokine phenotype

I. Michelozzi; Eduardo Gómez Castañeda; R. V. Pohle et al. · 2020

Full title: Enhanced functionality of low-affinity CD19 CAR T-cells is associated with activation priming and a polyfunctional cytokine phenotype

DOI: https://doi.org/10.1101/2020.09.22.291831

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CD62L-selected umbilical cord blood universal CAR T cells

C. Georgiadis; Lauren E Nickolay; Farhatullah Syed et al. · 2024

Full title: CD62L-selected umbilical cord blood universal CAR T cells

Authors: C. Georgiadis; Lauren E Nickolay; Farhatullah Syed; H. Zhan; S. A. Gkazi; Annie Etuk; Ulrike Abramowski-Mock; Roland Preece; Piotr Cuber; Stuart Adams; G. Ottaviano; W. Qasim

DOI: https://doi.org/10.1101/2024.01.18.576145

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Potentiation of Natural Killer Cells for Cancer Immunotherapy: A Review of Literature

Lowry, Lacy E.; Zehring, William A. · 2017

Full title: Potentiation of Natural Killer Cells for Cancer Immunotherapy: A Review of Literature

Authors: Lowry, Lacy E.; Zehring, William A.

DOI: https://doi.org/10.3389/fimmu.2017.01061

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Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells

Dawson, Nicholas A.J.; Vent‐Schmidt, Jens; Levings, Megan K. · 2017

Full title: Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells

Authors: Dawson, Nicholas A.J.; Vent‐Schmidt, Jens; Levings, Megan K.

DOI: https://doi.org/10.3389/fimmu.2017.01460

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Chimeric Antigen Receptor Expressing Natural Killer Cells for the Immunotherapy of Cancer

Mehta, Rohtesh S.; Rezvani, Katayoun · 2018

Full title: Chimeric Antigen Receptor Expressing Natural Killer Cells for the Immunotherapy of Cancer

Authors: Mehta, Rohtesh S.; Rezvani, Katayoun

DOI: https://doi.org/10.3389/fimmu.2018.00283

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Immunotherapy for Dogs: Running Behind Humans

Klingemann, Hans · 2018

Full title: Immunotherapy for Dogs: Running Behind Humans

Authors: Klingemann, Hans

DOI: https://doi.org/10.3389/fimmu.2018.00133

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Cytokine-Induced Killer Cells As Pharmacological Tools for Cancer Immunotherapy

Gao, Xingchun; Mi, Yajing; Guo, Na et al. · 2017

Full title: Cytokine-Induced Killer Cells As Pharmacological Tools for Cancer Immunotherapy

Authors: Gao, Xingchun; Mi, Yajing; Guo, Na; Xu, Hao; Xu, Lixian; Gou, Xingchun; Jin, Weilin

DOI: https://doi.org/10.3389/fimmu.2017.00774

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Clinical Grade Regulatory CD4+ T Cells (Tregs): Moving Toward Cellular-Based Immunomodulatory Therapies

Duggleby, Richard; Danby, Robert; Madrigal, J. Alejandro et al. · 2018

Full title: Clinical Grade Regulatory CD4+ T Cells (Tregs): Moving Toward Cellular-Based Immunomodulatory Therapies

Authors: Duggleby, Richard; Danby, Robert; Madrigal, J. Alejandro; Saudemont, Aurore

DOI: https://doi.org/10.3389/fimmu.2018.00252

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Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local

Pauza, C. David; Liou, Mei-Ling; Lahusen, Tyler et al. · 2018

Full title: Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local

Authors: Pauza, C. David; Liou, Mei-Ling; Lahusen, Tyler; Xiao, Lingzhi; Lapidus, Rena G.; Cairo, Cristiana; Li, Haishan

DOI: https://doi.org/10.3389/fimmu.2018.01305

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Immunological Approaches Towards Cancer and Inflammation: A Cross Talk

Qu, Xinglong; Tang, Ying; Hua, Shucheng · 2018

Full title: Immunological Approaches Towards Cancer and Inflammation: A Cross Talk

Authors: Qu, Xinglong; Tang, Ying; Hua, Shucheng

DOI: https://doi.org/10.3389/fimmu.2018.00563

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Extracellular NGFR Spacers Allow Efficient Tracking and Enrichment of Fully Functional CAR-T Cells Co-Expressing a Suicide Gene

M. Casucci; Laura Falcone; B. Camisa et al. · 2018

Full title: Extracellular NGFR Spacers Allow Efficient Tracking and Enrichment of Fully Functional CAR-T Cells Co-Expressing a Suicide Gene

Authors: M. Casucci; Laura Falcone; B. Camisa; M. Norelli; S. Porcellini; A. Stornaiuolo; F. Ciceri; C. Traversari; C. Bordignon; C. Bonini; A. Bondanza

DOI: https://doi.org/10.3389/fimmu.2018.00507

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GMP-Grade Manufacturing of T Cells Engineered to Express a Defined γδTCR

T. Straetemans; G. Kierkels; Ruud Doorn et al. · 2018

Full title: GMP-Grade Manufacturing of T Cells Engineered to Express a Defined γδTCR

DOI: https://doi.org/10.3389/fimmu.2018.01062

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Immune Cell Hacking: Challenges and Clinical Approaches to Create Smarter Generations of Chimeric Antigen Receptor T Cells

Elahi, Reza; Khosh, Elnaz; Tahmasebi, Safa et al. · 2018

Full title: Immune Cell Hacking: Challenges and Clinical Approaches to Create Smarter Generations of Chimeric Antigen Receptor T Cells

Authors: Elahi, Reza; Khosh, Elnaz; Tahmasebi, Safa; Esmaeilzadeh, Abdolreza

DOI: https://doi.org/10.3389/fimmu.2018.01717

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Perspectives on Chimeric Antigen Receptor T-Cell Immunotherapy for Solid Tumors

Kosti, Paris; Maher, John; Arnold, James N. · 2018

Full title: Perspectives on Chimeric Antigen Receptor T-Cell Immunotherapy for Solid Tumors

Authors: Kosti, Paris; Maher, John; Arnold, James N.

DOI: https://doi.org/10.3389/fimmu.2018.01104

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CAR T Cell Therapy for Neuroblastoma

Richards, Rebecca M.; Sotillo, Elena; Majzner, Robbie G. · 2018

Full title: CAR T Cell Therapy for Neuroblastoma

Authors: Richards, Rebecca M.; Sotillo, Elena; Majzner, Robbie G.

DOI: https://doi.org/10.3389/fimmu.2018.02380

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Inflammatory Cytokines Regulate T-Cell Development from Blood Progenitor Cells in a Stage and Dose-Specifc Manner

John M. Edgar; P. Zandstra · 2021

Full title: Inflammatory Cytokines Regulate T-Cell Development from Blood Progenitor Cells in a Stage and Dose-Specifc Manner

Authors: John M. Edgar; P. Zandstra

DOI: https://doi.org/10.1101/2021.01.18.427186

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The Potential of CAR T Cell Therapy in Pancreatic Cancer

Akce, Mehmet; Zaidi, Mohammad Y.; Waller, Edmund K. et al. · 2018

Full title: The Potential of CAR T Cell Therapy in Pancreatic Cancer

Authors: Akce, Mehmet; Zaidi, Mohammad Y.; Waller, Edmund K.; El‐Rayes, Bassel F.; Lesinski, Gregory B.

DOI: https://doi.org/10.3389/fimmu.2018.02166

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CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies

Knochelmann, Hannah M.; Smith, Aubrey S.; Dwyer, Connor J. et al. · 2018

Full title: CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies

Authors: Knochelmann, Hannah M.; Smith, Aubrey S.; Dwyer, Connor J.; Wyatt, Megan M.; Mehrotra, Shikhar; Paulos, Chrystal M.

DOI: https://doi.org/10.3389/fimmu.2018.01740

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Lymphocytes in Cellular Therapy: Functional Regulation of CAR T Cells

Dwivedi, Alka; Karulkar, Atharva; Ghosh, Sarbari et al. · 2019

Full title: Lymphocytes in Cellular Therapy: Functional Regulation of CAR T Cells

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DOI: https://doi.org/10.3389/fimmu.2018.03180

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Engineering CAR-T Cells for Improved Function Against Solid Tumors

Morgan, Michael; Schambach, Axel · 2018

Full title: Engineering CAR-T Cells for Improved Function Against Solid Tumors

Authors: Morgan, Michael; Schambach, Axel

DOI: https://doi.org/10.3389/fimmu.2018.02493

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Therapeutic Potential of Natural Killer Cells in Gastric Cancer

Du, Yu; Wei, Yongchang · 2019

Full title: Therapeutic Potential of Natural Killer Cells in Gastric Cancer

Authors: Du, Yu; Wei, Yongchang

DOI: https://doi.org/10.3389/fimmu.2018.03095

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HLA-Class II Artificial Antigen Presenting Cells in CD4+ T Cell-Based Immunotherapy

Couture, Alexandre; Garnier, Anthony; Docagne, Fabián et al. · 2019

Full title: HLA-Class II Artificial Antigen Presenting Cells in CD4+ T Cell-Based Immunotherapy

Authors: Couture, Alexandre; Garnier, Anthony; Docagne, Fabián; Boyer, Olivier; Vivien, Denis; LEMAUFF, BRIGITTE; Latouche, Jean‐Baptiste; Toutirais, Olivier

DOI: https://doi.org/10.3389/fimmu.2019.01081

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Cancer Immunotherapy Based on Natural Killer Cells: Current Progress and New Opportunities

Hu, Weilei; Wang, Guosheng; Huang, Dongsheng et al. · 2019

Full title: Cancer Immunotherapy Based on Natural Killer Cells: Current Progress and New Opportunities

Authors: Hu, Weilei; Wang, Guosheng; Huang, Dongsheng; Sui, Meihua; Xu, Yibing

DOI: https://doi.org/10.3389/fimmu.2019.01205

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Automated Clinical Grade Expansion of Regulatory T Cells in a Fully Closed System

José Manuel Marín Morales; Nadine Münch; K. Peter et al. · 2019

Full title: Automated Clinical Grade Expansion of Regulatory T Cells in a Fully Closed System

Authors: José Manuel Marín Morales; Nadine Münch; K. Peter; D. Freund; U. Oelschlägel; K. Hölig; T. Böhm; A. Flach; J. Kessler; E. Bonifacio; M. Bornhäuser; A. Fuchs

DOI: https://doi.org/10.3389/fimmu.2019.00038

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Cold Tumors: A Therapeutic Challenge for Immunotherapy

Bonaventura, Paola; Shekarian, Tala; Alcazer, Vincent et al. · 2019

Full title: Cold Tumors: A Therapeutic Challenge for Immunotherapy

Authors: Bonaventura, Paola; Shekarian, Tala; Alcazer, Vincent; Valladeau‐Guilemond, Jenny; Valsesia‐Wittmann, Sandrine; Amigorena, Sebastián; Caux, Christophe; Depil, Stéphane

DOI: https://doi.org/10.3389/fimmu.2019.00168

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Genetic Modification Strategies to Enhance CAR T Cell Persistence for Patients With Solid Tumors

DeRenzo, Christopher; Gottschalk, Stephen · 2019

Full title: Genetic Modification Strategies to Enhance CAR T Cell Persistence for Patients With Solid Tumors

Authors: DeRenzo, Christopher; Gottschalk, Stephen

DOI: https://doi.org/10.3389/fimmu.2019.00218

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L-Selectin Enhanced T Cells Improve the Efficacy of Cancer Immunotherapy

Watson, H. Angharad; Durairaj, Ruban Rex Peter; Ohme, Julia et al. · 2019

Full title: L-Selectin Enhanced T Cells Improve the Efficacy of Cancer Immunotherapy

DOI: https://doi.org/10.3389/fimmu.2019.01321

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Engineered T Cell Therapy for Cancer in the Clinic

Zhao, Lijun; Cao, Yu · 2019

Full title: Engineered T Cell Therapy for Cancer in the Clinic

Authors: Zhao, Lijun; Cao, Yu

DOI: https://doi.org/10.3389/fimmu.2019.02250

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The Synergistic Use of IL-15 and IL-21 for the Generation of NK Cells From CD3/CD19-Depleted Grafts Improves Their ex vivo Expansion and Cytotoxic Potential Against Neuroblastoma: Perspective for Optimized Immunotherapy Post Haploidentical Stem Cell Transplantation

Heinze, Annekathrin; Grebe, Beatrice; Bremm, Melanie et al. · 2019

DOI: https://doi.org/10.3389/fimmu.2019.02816

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Targeting Natural Killer Cells for Tumor Immunotherapy

Zhang, Cai; Hu, Yuan; Shi, Chongdeng · 2020

Full title: Targeting Natural Killer Cells for Tumor Immunotherapy

Authors: Zhang, Cai; Hu, Yuan; Shi, Chongdeng

DOI: https://doi.org/10.3389/fimmu.2020.00060

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Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector

Colamartino, A.; Lemieux, William; Bifsha, Panojot et al. · 2019

Full title: Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector

DOI: https://doi.org/10.3389/fimmu.2019.02873

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Universal Ready-to-Use Immunotherapeutic Approach for the Treatment of Cancer: Expanded and Activated Polyclonal γδ Memory T Cells

V. A. Polito; R. Cristantielli; G. Weber et al. · 2019

Full title: Universal Ready-to-Use Immunotherapeutic Approach for the Treatment of Cancer: Expanded and Activated Polyclonal γδ Memory T Cells

DOI: https://doi.org/10.3389/fimmu.2019.02717

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Exploiting Human NK Cells in Tumor Therapy

Vacca, Paola; Pietra, Gabriella; Tumino, Nicola et al. · 2020

Full title: Exploiting Human NK Cells in Tumor Therapy

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DOI: https://doi.org/10.3389/fimmu.2019.03013

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García‐Guerrero, Estefanía; Sierro-Martínez, Belén; Pérez-Simón, Josè Antonio · 2020

Full title: Overcoming Chimeric Antigen Receptor (CAR) Modified T-Cell Therapy Limitations in Multiple Myeloma

Authors: García‐Guerrero, Estefanía; Sierro-Martínez, Belén; Pérez-Simón, Josè Antonio

DOI: https://doi.org/10.3389/fimmu.2020.01128

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Next-Generation Manufacturing Protocols Enriching TSCM CAR T Cells Can Overcome Disease-Specific T Cell Defects in Cancer Patients.

Arcangeli, Silvia; Falcone, Laura; Camisa, Barbara et al. · 2020

Full title: Next-Generation Manufacturing Protocols Enriching TSCM CAR T Cells Can Overcome Disease-Specific T Cell Defects in Cancer Patients.

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Point-Of-Care CAR T-Cell Production (ARI-0001) Using a Closed Semi-automatic Bioreactor: Experience From an Academic Phase I Clinical Trial

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Full title: Point-Of-Care CAR T-Cell Production (ARI-0001) Using a Closed Semi-automatic Bioreactor: Experience From an Academic Phase I Clinical Trial

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Gamma-Delta CAR-T Cells Show CAR-Directed and Independent Activity Against Leukemia

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Full title: Gamma-Delta CAR-T Cells Show CAR-Directed and Independent Activity Against Leukemia

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The Next Frontier of Regulatory T Cells: Promising Immunotherapy for Autoimmune Diseases and Organ Transplantations

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Full title: The Next Frontier of Regulatory T Cells: Promising Immunotherapy for Autoimmune Diseases and Organ Transplantations

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Automated Manufacture of Autologous CD19 CAR-T Cells for Treatment of Non-hodgkin Lymphoma

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Full title: Automated Manufacture of Autologous CD19 CAR-T Cells for Treatment of Non-hodgkin Lymphoma

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Full title: Umbilical cord blood: an expandable resource.

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Full title: The Future of Regulatory T Cell Therapy: Promises and Challenges of Implementing CAR Technology

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Full title: Plasticity in Pro- and Anti-tumor Activity of Neutrophils: Shifting the Balance

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The BCMA-Targeted Fourth-Generation CAR-T Cells Secreting IL-7 and CCL19 for Therapy of Refractory/Recurrent Multiple Myeloma

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Full title: The BCMA-Targeted Fourth-Generation CAR-T Cells Secreting IL-7 and CCL19 for Therapy of Refractory/Recurrent Multiple Myeloma

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Cord-Blood Natural Killer Cell-Based Immunotherapy for Cancer

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Full title: Cord-Blood Natural Killer Cell-Based Immunotherapy for Cancer

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Glioblastoma Immune Landscape and the Potential of New Immunotherapies

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Full title: Glioblastoma Immune Landscape and the Potential of New Immunotherapies

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HLA Class I Knockout Converts Allogeneic Primary NK Cells Into Suitable Effectors for “Off-the-Shelf” Immunotherapy

Hoerster, Keven; Uhrberg, Markus; Wiek, Constanze et al. · 2021

Full title: HLA Class I Knockout Converts Allogeneic Primary NK Cells Into Suitable Effectors for “Off-the-Shelf” Immunotherapy

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Transcription Factors Associated With IL-15 Cytokine Signaling During NK Cell Development

Wang, Xiang; Zhao, Xiaosu · 2021

Full title: Transcription Factors Associated With IL-15 Cytokine Signaling During NK Cell Development

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GMP-Compliant Universal Antigen Presenting Cells (uAPC) Promote the Metabolic Fitness and Antitumor Activity of Armored Cord Blood CAR-NK Cells

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Full title: GMP-Compliant Universal Antigen Presenting Cells (uAPC) Promote the Metabolic Fitness and Antitumor Activity of Armored Cord Blood CAR-NK Cells

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Tr1 Cells as a Key Regulator for Maintaining Immune Homeostasis in Transplantation

Song, Yun; Wang, Ning; Chen, Lihua et al. · 2021

Full title: Tr1 Cells as a Key Regulator for Maintaining Immune Homeostasis in Transplantation

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Shaping Immune Responses in the Tumor Microenvironment of Ovarian Cancer

Luo, Xin; Xu, Jing; Yu, Jianhua et al. · 2021

Full title: Shaping Immune Responses in the Tumor Microenvironment of Ovarian Cancer

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Regulatory T Cells in GVHD Therapy

Guo, Wenwen; Su, Xiuhua; Wang, Mingyang et al. · 2021

Full title: Regulatory T Cells in GVHD Therapy

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Current Perspectives on “Off-The-Shelf” Allogeneic NK and CAR-NK Cell Therapies

Heipertz, Erica L.; Zynda, Evan R.; Stav-Noraas, Tor Espen et al. · 2021

Full title: Current Perspectives on “Off-The-Shelf” Allogeneic NK and CAR-NK Cell Therapies

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Engineered Cytokine Signaling to Improve CAR T Cell Effector Function

Bell, Matthew; Gottschalk, Stephen · 2021

Full title: Engineered Cytokine Signaling to Improve CAR T Cell Effector Function

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Advances in Adoptive Cell Therapy Using Induced Pluripotent Stem Cell-Derived T Cells

Ratchapong Netsrithong; Methichit Wattanapanitch · 2021

Full title: Advances in Adoptive Cell Therapy Using Induced Pluripotent Stem Cell-Derived T Cells

Authors: Ratchapong Netsrithong; Methichit Wattanapanitch

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Chimeric Antigen Receptor T-Cell Therapy in Lung Cancer: Potential and Challenges

Xiao, Bufan; Zhang, Jingtao; Zhu, Yuge et al. · 2021

Full title: Chimeric Antigen Receptor T-Cell Therapy in Lung Cancer: Potential and Challenges

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Gene-Edited Interleukin CAR-T Cells Therapy in the Treatment of Malignancies: Present and Future

Zhang, Zhengchao; Miao, Lele; Ren, Zhijian et al. · 2021

Full title: Gene-Edited Interleukin CAR-T Cells Therapy in the Treatment of Malignancies: Present and Future

Authors: Zhang, Zhengchao; Miao, Lele; Ren, Zhijian; Tang, Futian; Li, Yumin

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PiggyBac Transposon-Mediated CD19 Chimeric Antigen Receptor-T Cells Derived From CD45RA-Positive Peripheral Blood Mononuclear Cells Possess Potent and Sustained Antileukemic Function

M. Suematsu; S. Yagyu; Nobuyoshi Nagao et al. · 2022

Full title: PiggyBac Transposon-Mediated CD19 Chimeric Antigen Receptor-T Cells Derived From CD45RA-Positive Peripheral Blood Mononuclear Cells Possess Potent and Sustained Antileukemic Function

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CXCR6 expressing T cells: Functions and role in the control of tumors

Mabrouk, Nesrine; Tran, Thi; Sam, Ikuan et al. · 2022

Full title: CXCR6 expressing T cells: Functions and role in the control of tumors

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Taking Lessons from CAR-T Cells and Going Beyond: Tailoring Design and Signaling for CAR-NK Cells in Cancer Therapy

K. Ruppel; S. Fricke; U. Köhl et al. · 2022

Full title: Taking Lessons from CAR-T Cells and Going Beyond: Tailoring Design and Signaling for CAR-NK Cells in Cancer Therapy

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Feeder Cells at the Interface of Natural Killer Cell Activation, Expansion and Gene Editing

Gurney, Mark E.; Kundu, Soumyadipta; Pandey, Shubham et al. · 2022

Full title: Feeder Cells at the Interface of Natural Killer Cell Activation, Expansion and Gene Editing

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GMP-Compliant Manufacturing of TRUCKs: CAR T Cells targeting GD2 and Releasing Inducible IL-18

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Full title: GMP-Compliant Manufacturing of TRUCKs: CAR T Cells targeting GD2 and Releasing Inducible IL-18

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Innovative Strategies to Improve the Clinical Application of NK Cell-Based Immunotherapy

Tarannum, Mubin; Romee, Rizwan; Shapiro, Roman M. · 2022

Full title: Innovative Strategies to Improve the Clinical Application of NK Cell-Based Immunotherapy

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Anti-PD-1 Therapy Enhances the Efficacy of CD30-Directed Chimeric Antigen Receptor T Cell Therapy in Patients With Relapsed/Refractory CD30+ Lymphoma

Sang, Wei; Wang, Xiangmin; Geng, Hongzhi et al. · 2022

Full title: Anti-PD-1 Therapy Enhances the Efficacy of CD30-Directed Chimeric Antigen Receptor T Cell Therapy in Patients With Relapsed/Refractory CD30+ Lymphoma

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Singh, Harjeet; Figliola, Matthew J.; Dawson, Margaret J. et al. · 2013

Full title: Manufacture of Clinical-Grade CD19-Specific T Cells Stably Expressing Chimeric Antigen Receptor Using Sleeping Beauty System and Artificial Antigen Presenting Cells

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Davila, Marco L.; Kloss, Christopher C.; Gunset, Gertrude et al. · 2013

Full title: CD19 CAR-Targeted T Cells Induce Long-Term Remission and B Cell Aplasia in an Immunocompetent Mouse Model of B Cell Acute Lymphoblastic Leukemia

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Full title: Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8+ Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell Therapy

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Full title: In vitro immunotherapy potency assays using real-time cell analysis

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Full title: Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations

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Full title: Multiparameter comparative analysis reveals differential impacts of various cytokines on CART cell phenotype and function ex vivo and in vivo

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Full title: PD1 blockade enhances cytotoxicity of in vitro expanded natural killer cells towards myeloma cells

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Full title: Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor

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Full title: Immunotherapy of acute leukemia by chimeric antigen receptor-modified lymphocytes using an improved Sleeping Beauty transposon platform

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Full title: CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia

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Full title: Clinical Application of Cytokines in Cancer Immunotherapy

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Full title: Characterization of CAR T Cells Manufactured Using Genetically Engineered Artificial Antigen Presenting Cells

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Full title: Preclinical development of a protocol for the manufacturing of anti-CD5 CAR-T lymphocytes for the treatment of T-lineage acute lymphoblastic leukemia and lymphoma

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Full title: Comparative characterization of the cell composition and functional properties of anti-CD19 biomedical cell products manufactured using the CliniMACS Prodigy and G-Rex platforms

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Full title: CD28.OX40 co-stimulatory combination is associated with long in vivo persistence and high activity of CAR.CD30 T cells

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Full title: Chimeric antigen receptor T-cell therapy in childhood acute myeloid leukemia: how far are we from a clinical application?

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Full title: Umbilical cord blood T cells can be isolated and enriched by CD62L selection for use in ‘off the shelf’ chimeric antigen receptor T-cell therapies to widen transplant options

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Full title: Excellent proliferation and persistence of allogeneic donor-derived 41-BB based CAR-T cells despite immunosuppression with cyclosporine A

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Full title: Piloting a scale-up platform for high-quality human T-cells production

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Full title: Tailored Cytokine Optimization for ex vivo Culture Platforms Targeting the Expansion of Human Hematopoietic Stem/Progenitor Cells

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Full title: Optimising and adapting perfusion feeds in serum-free medium to intensify CAR-T cell expansion in stirred-tank bioreactors.

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Full title: TCR-Engineered T Cells Meet New Challenges to Treat Solid Tumors: Choice of Antigen, T Cell Fitness, and Sensitization of Tumor Milieu

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Natural Killer Cells for Cancer Immunotherapy: Pluripotent Stem Cells-Derived NK Cells as an Immunotherapeutic Perspective

Eguizábal, Cristina; Zenarruzabeitia, Olatz; Monge, Jorge et al. · 2014

Full title: Natural Killer Cells for Cancer Immunotherapy: Pluripotent Stem Cells-Derived NK Cells as an Immunotherapeutic Perspective

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Full title: Natural Killer Cell-Based Therapies Targeting Cancer: Possible Strategies to Gain and Sustain Anti-Tumor Activity

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Lafont, Virginie; Sanchez, FranÃ§oise; Laprévotte, Emilie et al. · 2014

Full title: Plasticity of Î³Î´ T Cells: Impact on the Anti-Tumor Response

Authors: Lafont, Virginie; Sanchez, FranÃ§oise; Laprévotte, Emilie; Michaud, Henri‐Alexandre; Gros, Laurent; Eliaou, Jean-FranÃ§ois; Bonnefoy, Nathalie

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Rezvani, Katayoun; Rouce, Rayne H. · 2015

Full title: The Application of Natural Killer Cell Immunotherapy for the Treatment of Cancer

Authors: Rezvani, Katayoun; Rouce, Rayne H.

DOI: https://doi.org/10.3389/fimmu.2015.00578

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Granzin, Markus; Wagner, Juliane; Köhl, Ulrike et al. · 2017

Full title: Shaping of Natural Killer Cell Antitumor Activity by Ex Vivo Cultivation

Authors: Granzin, Markus; Wagner, Juliane; Köhl, Ulrike; Cerwenka, Adelheid; Huppert, Volker; Ullrich, Evelyn

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Genetic Manipulation of NK Cells for Cancer Immunotherapy: Techniques and Clinical Implications

Carlsten, Mattias; Childs, Richard · 2015

Full title: Genetic Manipulation of NK Cells for Cancer Immunotherapy: Techniques and Clinical Implications

Authors: Carlsten, Mattias; Childs, Richard

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Safinia, Niloufar; Scottà, Cristiano; Vaikunthanathan, Trishan et al. · 2015

Full title: Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation

Authors: Safinia, Niloufar; Scottà, Cristiano; Vaikunthanathan, Trishan; Lechler, Robert I.; Lombardi, Giovanna

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Veluchamy, John P.; Kok, Nina; Vliet, Hans van et al. · 2017

Full title: The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments

Authors: Veluchamy, John P.; Kok, Nina; Vliet, Hans van; Verheul, Henk M.W.; Gruijl, Tanja D. de; Spanholtz, Jan

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Redeker, Anke; Arens, Ramon · 2016

Full title: Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination

Authors: Redeker, Anke; Arens, Ramon

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Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel.

Irving, Melita; Vuillefroy de Silly, Romain; Scholten, Kirsten et al. · 2017

Full title: Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel.

Authors: Irving, Melita; Vuillefroy de Silly, Romain; Scholten, Kirsten; Dilek, Nahzli; Coukos, George

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Chimeric Antigen Receptors T Cell Therapy in Solid Tumor: Challenges and Clinical Applications

Mirzaei, Hamid Reza; Rodriguez, Analiz; Shepphird, Jennifer Kelly et al. · 2017

Full title: Chimeric Antigen Receptors T Cell Therapy in Solid Tumor: Challenges and Clinical Applications

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Dezfouli, Ali Bashiri; Yazdi, Mina; Pockley, A. Graham et al. · 2021

Full title: NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development

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Full title: Improving CAR T-Cell Persistence

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BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia

Kong, Weimin; Dimitri, Alexander J.; Wenliang, Wang et al. · 2021

Full title: BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia

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Sleeping Beauty-engineered CAR T cells achieve anti-leukemic activity without severe toxicities.

Chiara F. Magnani; G. Gaipa; F. Lussana et al. · 2020

Full title: Sleeping Beauty-engineered CAR T cells achieve anti-leukemic activity without severe toxicities.

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CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome.

Arcangeli, Silvia; Bove, Camilla; Mezzanotte, Claudia et al. · 2022

Full title: CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome.

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CAR therapy: the CD19 paradigm

Sadelain, Michel · 2015

Full title: CAR therapy: the CD19 paradigm

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CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients.

C. Turtle; L. Hanafi; C. Berger et al. · 2016

Full title: CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients.

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Kagoya, Yuki; Nakatsugawa, Munehide; Ochi, Toshiki et al. · 2017

Full title: Transient stimulation expands superior antitumor T cells for adoptive therapy

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Guedan, Sònia; Posey, Avery D.; Shaw, Carolyn E. et al. · 2018

Full title: Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation

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Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection

Parrot, Tiphaine; Healy, Katie; Boulouis, Caroline et al. · 2021

Full title: Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection

Authors: Parrot, Tiphaine; Healy, Katie; Boulouis, Caroline; Sobkowiak, Michał J.; Leeansyah, Edwin; Aleman, Soo; Bertoletti, Antonio; Chen, Margaret; Sandberg, Johan K.

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Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity

Wang, Dongrui; Aguilar, Brenda; Starr, Renate et al. · 2018

Full title: Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity

Authors: Wang, Dongrui; Aguilar, Brenda; Starr, Renate; Alizadeh, Darya; Brito, Alfonso; Sarkissian, Aniee; Ostberg, Julie R.; Forman, Stephen J.; Brown, Christine E.

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Maia, Andreia; Tarannum, Mubin; Lérias, Joana R. et al. · 2024

Full title: Building a Better Defense: Expanding and Improving Natural Killer Cells for Adoptive Cell Therapy

Authors: Maia, Andreia; Tarannum, Mubin; Lérias, Joana R.; Piccinelli, Sara; Borrego, Luís Miguel; Maeurer, Markus; Romee, Rizwan; Castillo-Martín, Mireia

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‘Off-the-Shelf’ Immunotherapy: Manufacture of CD8+ T Cells Derived from Hematopoietic Stem Cells

N. Boyd; K. Cartledge; H. Cao et al. · 2021

Full title: ‘Off-the-Shelf’ Immunotherapy: Manufacture of CD8+ T Cells Derived from Hematopoietic Stem Cells

Authors: N. Boyd; K. Cartledge; H. Cao; V. Evtimov; Aleta Pupovac; A. Trounson; R. Boyd

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Recent Advances in CAR-Based Solid Tumor Immunotherapy

Shin, Min Hwa; Oh, Eunha; Kim, Yun Jeong et al. · 2023

Full title: Recent Advances in CAR-Based Solid Tumor Immunotherapy

Authors: Shin, Min Hwa; Oh, Eunha; Kim, Yun Jeong; Nam, Dae-Hwan; Jeon, Soyoung; Yu, Jin Hyuk; Minn, Dohsik

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IL7-IL12 Engineered Mesenchymal Stem Cells (MSCs) Improve A CAR T Cell Attack Against Colorectal Cancer Cells

Hombach, Andreas; Geumann, Ulf; Günther, Christine et al. · 2020

Full title: IL7-IL12 Engineered Mesenchymal Stem Cells (MSCs) Improve A CAR T Cell Attack Against Colorectal Cancer Cells

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Investigation of the Impact from IL-2, IL-7, and IL-15 on the Growth and Signaling of Activated CD4+ T Cells

Canaan Coppola; B. Hopkins; S. Huhn et al. · 2020

Full title: Investigation of the Impact from IL-2, IL-7, and IL-15 on the Growth and Signaling of Activated CD4+ T Cells

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Interleukin 15 in Cell-Based Cancer Immunotherapy

Zhou, Yang; Husman, Tiffany; Cen, Xinjian et al. · 2022

Full title: Interleukin 15 in Cell-Based Cancer Immunotherapy

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The Generation of CAR-Transfected Natural Killer T Cells for the Immunotherapy of Melanoma

Simon, Bianca; Wiesinger, Manuel; März, Johannes et al. · 2018

Full title: The Generation of CAR-Transfected Natural Killer T Cells for the Immunotherapy of Melanoma

Authors: Simon, Bianca; Wiesinger, Manuel; März, Johannes; Wistuba‐Hamprecht, Kilian; Weide, Benjamin; Schuler‐Thurner, Beatrice; Schuler, Gerold; Dörrie, Jan; Uslu, Uğur

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CAR-NK Cells Generated with mRNA-LNPs Kill Tumor Target Cells In Vitro and In Vivo

Golubovskaya, Vita; Sienkiewicz, John; Sun, Jinying et al. · 2023

Full title: CAR-NK Cells Generated with mRNA-LNPs Kill Tumor Target Cells In Vitro and In Vivo

Authors: Golubovskaya, Vita; Sienkiewicz, John; Sun, Jinying; Zhang, Shiming; Huang, Yanwei; Zhou, Hua; Harto, Hizkia; Xu, Shirley; Berahovich, Robert; Wu, Lijun

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Optimizing Manufacturing Protocols of Chimeric Antigen Receptor T Cells for Improved Anticancer Immunotherapy

S. Stock; M. Schmitt; L. Sellner · 2019

Full title: Optimizing Manufacturing Protocols of Chimeric Antigen Receptor T Cells for Improved Anticancer Immunotherapy

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CAR T-Cell Therapy in Hematological Malignancies

Haslauer, Theresa; Greil, Richard; Zaborsky, Nadja et al. · 2021

Full title: CAR T-Cell Therapy in Hematological Malignancies

Authors: Haslauer, Theresa; Greil, Richard; Zaborsky, Nadja; Geisberger, Roland

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CAR T-Cell Persistence Correlates with Improved Outcome in Patients with B-Cell Lymphoma

Wittibschlager, Valerie; Bacher, Ulrike; Seipel, Katja et al. · 2023

Full title: CAR T-Cell Persistence Correlates with Improved Outcome in Patients with B-Cell Lymphoma

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Full title: Upregulation of the TCA Cycle and Oxidative Phosphorylation Enhances the Fitness of CD99 CAR-T Cells Under Dynamic Cultivation

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CliniMACS Prodigy Manufacturing of Switchable, AND-Gate CAR T Cells

Alexandra von Jutrzenka-Trzebiatowski; R. Gupte; Cansu Daglar et al. · 2025

Full title: CliniMACS Prodigy Manufacturing of Switchable, AND-Gate CAR T Cells

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Rapidly Manufactured CAR-T with Conserved Cell Stemness and Distinctive Cytokine-Secreting Profile Shows Improved Anti-Tumor Efficacy

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Full title: Rapidly Manufactured CAR-T with Conserved Cell Stemness and Distinctive Cytokine-Secreting Profile Shows Improved Anti-Tumor Efficacy

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Roex, Gils; Feys, Tom; Béguin, Yves et al. · 2020

Full title: Chimeric Antigen Receptor-T-Cell Therapy for B-Cell Hematological Malignancies: An Update of the Pivotal Clinical Trial Data

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Full title: Membrane Applications in Autologous Cell Therapy

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Full title: A Microfluidic-Based Sensing Platform for Rapid Quality Control on Target Cells from Bioreactors

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Shen, Luxi; Li, Hongzhi; Bin, Shufang et al. · 2019

Full title: The efficacy of third generation anti‑HER2 chimeric antigen receptor T�cells in combination with PD1 blockade against malignant glioblastoma cells

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Full title: Impact of serum-free media on the expansion and functionality of CD19.CAR T-cells

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Full title: CAR-T CELL THERAPY FOR CHRONIC LYMPHOCYTIC LEUKEMIA: A PROMISING IMMUNOTHERAPY APPROACH

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Full title: Genetically engineered T cells for cancer immunotherapy

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Full title: NF-κB in biology and targeted therapy: new insights and translational implications

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Full title: γδ T cells: origin and fate, subsets, diseases and immunotherapy

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Full title: Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission

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Full title: Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8+ T cells

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Full title: Generation of allogeneic CAR-NKT cells from hematopoietic stem and progenitor cells using a clinically guided culture method

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Full title: Natural killer cells in cancer biology and therapy

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Gisela Maria Suárez Formigo; Zaima Mazorra; Cinthia Olexen et al. · 2026

Full title: Cancer immunotherapy insights: key takeaways from the ADSCC bone marrow and cellular therapy congress 2024

DOI: https://doi.org/10.3389/fimmu.2025.1650023

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IL-21 Optimizes the CAR-T Cell Preparation Through Improving Lentivirus Mediated Transfection Efficiency of T Cells and Enhancing CAR-T Cell Cytotoxic Activities

L. Du; Yaru Nai; Meiying Shen et al. · 2021

Full title: IL-21 Optimizes the CAR-T Cell Preparation Through Improving Lentivirus Mediated Transfection Efficiency of T Cells and Enhancing CAR-T Cell Cytotoxic Activities

Authors: L. Du; Yaru Nai; Meiying Shen; Tingting Li; Jingjing Huang; Xiaojian Han; Wang Wang; D. Pang; A. Jin

DOI: https://doi.org/10.3389/fmolb.2021.675179

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Administration of granulocyte-macrophage colony-stimulating factor enhanced chimeric antigen receptor T-cell expansion and cellular immunity recovery without inducing cytokine release syndrome.

Jiang, Ying; Feng, Dan; Wang, Chun et al. · 2022

Authors: Jiang, Ying; Feng, Dan; Wang, Chun; Zhang, Yanlei; Zhao, Chuxian; Li, Su; Qin, Youwen; Chang, Alex H; Zhu, Jun

DOI: https://doi.org/10.3389/fmed.2022.1042501

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A Metabolism Toolbox for CAR T Therapy

Xu, Xuequn; Gnanaprakasam, JN Rashida; Sherman, John et al. · 2019

Full title: A Metabolism Toolbox for CAR T Therapy

Authors: Xu, Xuequn; Gnanaprakasam, JN Rashida; Sherman, John; Wang, Ruoning

DOI: https://doi.org/10.3389/fonc.2019.00322

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The Third Generation Anti-HER2 Chimeric Antigen Receptor Mouse T Cells Alone or Together With Anti-PD1 Antibody Inhibits the Growth of Mouse Breast Tumor Cells Expressing HER2 in vitro and in Immune Competent Mice

Li, Panyuan; Yang, Lingcong; Li, Tong et al. · 2020

Authors: Li, Panyuan; Yang, Lingcong; Li, Tong; Bin, Shufang; Sun, Bohao; Huang, Yuting; Yang, Kaiyan; Shan, Daming; Gu, Haihua; Li, Hongzhi

DOI: https://doi.org/10.3389/fonc.2020.01143

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Altered T-Lymphocyte Biology Following High-Dose Melphalan and Autologous Stem Cell Transplantation With Implications for Adoptive T-Cell Therapy

T. Mika; Swetlana Ladigan-Badura; A. Maghnouj et al. · 2020

Full title: Altered T-Lymphocyte Biology Following High-Dose Melphalan and Autologous Stem Cell Transplantation With Implications for Adoptive T-Cell Therapy

Authors: T. Mika; Swetlana Ladigan-Badura; A. Maghnouj; B. Mustafa; S. Klein-Scory; A. Baraniskin; Sascha Döhring; Ilka Fuchs; S. Ehl; S. Hahn; R. Schroers

DOI: https://doi.org/10.3389/fonc.2020.568056

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TCR-T Immunotherapy: The Challenges and Solutions

Liu, Yating; Yan, Xin; Zhang, Fan et al. · 2022

Full title: TCR-T Immunotherapy: The Challenges and Solutions

Authors: Liu, Yating; Yan, Xin; Zhang, Fan; Zhang, Xiaoxia; Tang, Futian; Han, Zhijian; Li, Yumin

DOI: https://doi.org/10.3389/fonc.2021.794183

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Chimeric Antigen Receptor-T Cells: A Pharmaceutical Scope

Hernández-López, Alejandrina; Téllez-González, Mario A.; Mondragón‐Terán, Paul et al. · 2021

Full title: Chimeric Antigen Receptor-T Cells: A Pharmaceutical Scope

Authors: Hernández-López, Alejandrina; Téllez-González, Mario A.; Mondragón‐Terán, Paul; Meneses‐Acosta, Angélica

DOI: https://doi.org/10.3389/fphar.2021.720692

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Adoptive NK Cell Therapy - a Beacon of Hope in Multiple Myeloma Treatment

Son Hai Vu; Ha Hong Pham; Thao Thi Phuong Pham et al. · 2023

Full title: Adoptive NK Cell Therapy - a Beacon of Hope in Multiple Myeloma Treatment

Authors: Son Hai Vu; Ha Hong Pham; Thao Thi Phuong Pham; Thanh Thien Le; Manh-Cuong Vo; S. Jung; Je-Jung Lee; Xuan-Hung Nguyen

DOI: https://doi.org/10.3389/fonc.2023.1275076

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Umbilical Cord Blood Transplants: Current Status and Evolving Therapies

Gupta, Ashish O.; Wagner, John E. · 2020

Full title: Umbilical Cord Blood Transplants: Current Status and Evolving Therapies

Authors: Gupta, Ashish O.; Wagner, John E.

DOI: https://doi.org/10.3389/fped.2020.570282

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Breakthrough for Anticancer Immunotherapy: Current Advances in Manufacturing Protocols of Chimeric Antigen Receptor-Based Therapies

Yuxin Qian; Weiwei Ma; Xiao-Ning Xu · 2025

Full title: Breakthrough for Anticancer Immunotherapy: Current Advances in Manufacturing Protocols of Chimeric Antigen Receptor-Based Therapies

Authors: Yuxin Qian; Weiwei Ma; Xiao-Ning Xu

DOI: https://doi.org/10.3390/antib14040105

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Natural Killer Cells as Allogeneic Effectors in Adoptive Cancer Immunotherapy

Lupo, Kyle B.; Matosevic, Sandro · 2019

Full title: Natural Killer Cells as Allogeneic Effectors in Adoptive Cancer Immunotherapy

Authors: Lupo, Kyle B.; Matosevic, Sandro

DOI: https://doi.org/10.3390/cancers11060769

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Advantages and applications of CAR-expressing natural killer cells

Glienke, Wolfgang; Esser, Ruth; Priesner, Christoph et al. · 2015

Full title: Advantages and applications of CAR-expressing natural killer cells

Authors: Glienke, Wolfgang; Esser, Ruth; Priesner, Christoph; Suerth, Julia D.; Schambach, Axel; Wels, Winfried S.; Grez, Manuel; Kloeß, Stephan; Arseniev, Lubomir; Koehl, Ulrike

DOI: https://doi.org/10.3389/fphar.2015.00021

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Research progress of interleukin-15 in cancer immunotherapy

Cai, Menghan; Huang, Xuan; Huang, Xiting et al. · 2023

Full title: Research progress of interleukin-15 in cancer immunotherapy

Authors: Cai, Menghan; Huang, Xuan; Huang, Xiting; Ju, Dianwen; Zhu, Yi; Li, Ye

DOI: https://doi.org/10.3389/fphar.2023.1184703

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Assessing the Future of Solid Tumor Immunotherapy

Guha, Prajna; Heatherton, Kara R.; O’Connell, Kyle et al. · 2022

Full title: Assessing the Future of Solid Tumor Immunotherapy

Authors: Guha, Prajna; Heatherton, Kara R.; O’Connell, Kyle; Alexander, Ian S.; Katz, Steven C.

DOI: https://doi.org/10.3390/biomedicines10030655

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Mechanisms of Resistance to NK Cell Immunotherapy

Sordo‐Bahamonde, Christian; Vitale, Massimo; Lorenzo‐Herrero, Seila et al. · 2020

Full title: Mechanisms of Resistance to NK Cell Immunotherapy

Authors: Sordo‐Bahamonde, Christian; Vitale, Massimo; Lorenzo‐Herrero, Seila; López‐Soto, Alejandro; González, Segundo

DOI: https://doi.org/10.3390/cancers12040893

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NK-Cell-Mediated Targeting of Various Solid Tumors Using a B7-H3 Tri-Specific Killer Engager In Vitro and In Vivo

Vallera, Daniel A.; Ferrone, Soldano; Kodal, Behiye et al. · 2020

Full title: NK-Cell-Mediated Targeting of Various Solid Tumors Using a B7-H3 Tri-Specific Killer Engager In Vitro and In Vivo

DOI: https://doi.org/10.3390/cancers12092659

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Ovarian Cancer Immunotherapy: Preclinical Models and Emerging Therapeutics

McCloskey, Curtis W.; Rodriguez, Galaxia M.; Galpin, Kristianne J.C. et al. · 2018

Full title: Ovarian Cancer Immunotherapy: Preclinical Models and Emerging Therapeutics

Authors: McCloskey, Curtis W.; Rodriguez, Galaxia M.; Galpin, Kristianne J.C.; Vanderhyden, Barbara C.

DOI: https://doi.org/10.3390/cancers10080244

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Clinical-Scale Production of CAR-T Cells for the Treatment of Melanoma Patients by mRNA Transfection of a CSPG4-Specific CAR under Full GMP Compliance

Wiesinger, Manuel; März, Johannes; Kummer, Mirko et al. · 2019

Full title: Clinical-Scale Production of CAR-T Cells for the Treatment of Melanoma Patients by mRNA Transfection of a CSPG4-Specific CAR under Full GMP Compliance

Authors: Wiesinger, Manuel; März, Johannes; Kummer, Mirko; Schuler, Gerold; Dörrie, Jan; Schuler‐Thurner, Beatrice; Schaft, Niels

DOI: https://doi.org/10.3390/cancers11081198

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3D Culture Systems for Exploring Cancer Immunology

Fitzgerald, Allison A.; Li, Eric; Weiner, Louis M. · 2020

Full title: 3D Culture Systems for Exploring Cancer Immunology

Authors: Fitzgerald, Allison A.; Li, Eric; Weiner, Louis M.

DOI: https://doi.org/10.3390/cancers13010056

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Co-Expression of IL-7 Improves NKG2D-Based CAR T Cell Therapy on Prostate Cancer by Enhancing the Expansion and Inhibiting the Apoptosis and Exhaustion

He, Cong; Zhou, Ying; Li, Zhenlong et al. · 2020

Full title: Co-Expression of IL-7 Improves NKG2D-Based CAR T Cell Therapy on Prostate Cancer by Enhancing the Expansion and Inhibiting the Apoptosis and Exhaustion

Authors: He, Cong; Zhou, Ying; Li, Zhenlong; Farooq, Muhammad Asad; Ajmal, Iqra; Zhang, Hongmei; Zhang, Li; Tao, Lei; Yao, Jie; Du, Bing; Liu, Mingyao; Jiang, Wenzheng

DOI: https://doi.org/10.3390/cancers12071969

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Immunomodulatory Effects of IL-2 and IL-15; Implications for Cancer Immunotherapy

Yang, Ying; Lundqvist, Andreas · 2020

Full title: Immunomodulatory Effects of IL-2 and IL-15; Implications for Cancer Immunotherapy

Authors: Yang, Ying; Lundqvist, Andreas

DOI: https://doi.org/10.3390/cancers12123586

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CAR-NK Cells: A Chimeric Hope or a Promising Therapy?

M. Sabbah; Ludovic Jondreville; C. Lacan et al. · 2022

Full title: CAR-NK Cells: A Chimeric Hope or a Promising Therapy?

Authors: M. Sabbah; Ludovic Jondreville; C. Lacan; F. Norol; V. Vieillard; Damien Roos-Weil; Stephanie A Nguyen

DOI: https://doi.org/10.3390/cancers14153839

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NK Cell Therapy: A Rising Star in Cancer Treatment

Du, Nawen; Guo, Feifei; Wang, Yufeng et al. · 2021

Full title: NK Cell Therapy: A Rising Star in Cancer Treatment

Authors: Du, Nawen; Guo, Feifei; Wang, Yufeng; Cui, Jiuwei

DOI: https://doi.org/10.3390/cancers13164129

Paper

Recent Advances and Challenges in Cancer Immunotherapy

Peterson, Chelsea; Denlinger, Nathan; Yang, Yiping · 2022

Full title: Recent Advances and Challenges in Cancer Immunotherapy

Authors: Peterson, Chelsea; Denlinger, Nathan; Yang, Yiping

DOI: https://doi.org/10.3390/cancers14163972

Paper

Role of CAR T Cell Metabolism for Therapeutic Efficacy

Saborido, Judit Rial; Völkl, Simon; Aigner, Michael et al. · 2022

Full title: Role of CAR T Cell Metabolism for Therapeutic Efficacy

Authors: Saborido, Judit Rial; Völkl, Simon; Aigner, Michael; Mackensen, Andréas; Mougiakakos, Dimitrios

DOI: https://doi.org/10.3390/cancers14215442

Paper

Development and Validation of a Good Manufacturing Process for IL-4-Driven Expansion of Chimeric Cytokine Receptor-Expressing CAR T-Cells

May C I van Schalkwyk; Sjoukje J. C. van der Stegen; Leticia Bosshard-Carter et al. · 2021

Full title: Development and Validation of a Good Manufacturing Process for IL-4-Driven Expansion of Chimeric Cytokine Receptor-Expressing CAR T-Cells

Authors: May C I van Schalkwyk; Sjoukje J. C. van der Stegen; Leticia Bosshard-Carter; Helen Graves; S. Papa; Ana C. Parente-Pereira; F. Farzaneh; C. Fisher; A. Hope; A. Adami; J. Maher

DOI: https://doi.org/10.3390/cells10071797

Paper

DCision-making in tumors governs T cell anti-tumor immunity

Alfei, Francesca; Ho, Ping‐Chih; Lo, Wan‐Lin · 2021

Full title: DCision-making in tumors governs T cell anti-tumor immunity

Authors: Alfei, Francesca; Ho, Ping‐Chih; Lo, Wan‐Lin

DOI: https://doi.org/10.1038/s41388-021-01946-8

Paper

Comparative analysis and process optimization for manufacturing CAR-T using the PiggyBac system derived from cryopreserved versus fresh PBMCs

Zenghui Xu; Ruyue Wang; Yuanjian Xu et al. · 2025

Full title: Comparative analysis and process optimization for manufacturing CAR-T using the PiggyBac system derived from cryopreserved versus fresh PBMCs

Authors: Zenghui Xu; Ruyue Wang; Yuanjian Xu; Ruijuan Qiu; Jiangrui Chen; Linfeng Liu; Qijun Qian

DOI: https://doi.org/10.1038/s41598-025-89686-7

Paper

Dexamethasone Enhances CAR T Cell Persistence and Function by Upregulating Interleukin 7 Receptor

A. Munoz; Ryan Urak; Ellie Taus et al. · 2022

Full title: Dexamethasone Enhances CAR T Cell Persistence and Function by Upregulating Interleukin 7 Receptor

Authors: A. Munoz; Ryan Urak; Ellie Taus; Claire Hsieh; Katherine Jin; Shu-Hong Lin; D. Awuah; Vibhuti Vyas; S. Priceman; Mary C. Clark; S. Forman; Xiuli Wang

DOI: https://doi.org/10.1101/2022.08.29.505735

Paper

Engineering chimeric antigen receptor-T cells for cancer treatment

Ye, Baixin; Stary, Creed M.; Li, Xuejun et al. · 2018

Full title: Engineering chimeric antigen receptor-T cells for cancer treatment

Authors: Ye, Baixin; Stary, Creed M.; Li, Xuejun; Qingping, Gao; Kang, Chunsheng; Xiong, Xiaoxing

DOI: https://doi.org/10.1186/s12943-018-0814-0

Paper

T-cell receptor-based therapy: an innovative therapeutic approach for solid tumors

Tsimberidou, Apostolia M.; Morris, Karlyle Van; Vo, Henry Hiep et al. · 2021

Full title: T-cell receptor-based therapy: an innovative therapeutic approach for solid tumors

Authors: Tsimberidou, Apostolia M.; Morris, Karlyle Van; Vo, Henry Hiep; Eck, Stephen; Lin, Yu‐Feng; Rivas, Jorge Mauricio; Andersson, Börje S.

DOI: https://doi.org/10.1186/s13045-021-01115-0

Paper

IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblasts

Eynde, Astrid Van den; Gehrcken, Laura; Verhezen, Tias et al. · 2024

Full title: IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblasts

DOI: https://doi.org/10.1186/s13045-024-01525-w

Paper

Redirecting Specificity of T cells Using the Sleeping Beauty System to Express Chimeric Antigen Receptors by Mix-and-Matching of VL and VH Domains Targeting CD123+ Tumors

Thokala, Radhika; Olivares, Simon; Mi, Tiejuan et al. · 2016

Full title: Redirecting Specificity of T cells Using the Sleeping Beauty System to Express Chimeric Antigen Receptors by Mix-and-Matching of VL and VH Domains Targeting CD123+ Tumors

DOI: https://doi.org/10.1371/journal.pone.0159477

Paper

Scalable CAR-T production in a 2-litre perfusion stirred-tank bioreactor with automated harvesting and scale-down model characterisation.

Springuel, Pierre; Silva Couto, Pedro; Stibbs, Dale J et al. · 2025

Full title: Scalable CAR-T production in a 2-litre perfusion stirred-tank bioreactor with automated harvesting and scale-down model characterisation.

DOI: https://doi.org/10.3389/fbioe.2025.1694134

Paper

CAR T Cell Therapy of Non-hematopoietic Malignancies: Detours on the Road to Clinical Success

Long, Kristen B.; Young, Regina M.; Boesteanu, Alina C. et al. · 2018

Full title: CAR T Cell Therapy of Non-hematopoietic Malignancies: Detours on the Road to Clinical Success

Authors: Long, Kristen B.; Young, Regina M.; Boesteanu, Alina C.; Davis, Megan M.; Melenhorst, J. Joseph; Lacey, Simon F.; Degaramo, David; Levine, Bruce L.; Fraietta, Joseph A.

DOI: https://doi.org/10.3389/fimmu.2018.02740

Thesis

Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Zhang, Liang · 2020

Full title: Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

Authors: Zhang, Liang

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-273343

Thesis

A systematic review of decision-support tools for regenerative medicine

Lam, Ching; Meinert, Edward; Alturkistani, Abrar et al. · 2019

Full title: A systematic review of decision-support tools for regenerative medicine

Authors: Lam, Ching; Meinert, Edward; Alturkistani, Abrar; Carter, Alison; Karp, Jeffery; Yang, Aidong; Brindley, David; Zhanfeg, Cui

DOI: https://www.jmir.org/2018/12/e12448/

Thesis

In-vitro Glioblastoma Treatment Focusing on Convection Enhanced Delivery

Brocke, Conner Ethan · 2022

Full title: In-vitro Glioblastoma Treatment Focusing on Convection Enhanced Delivery

Authors: Brocke, Conner Ethan

DOI: http://hdl.handle.net/10919/110333

Thesis

The S enantiomer of 2-hydroxyglutarate increases central memory CD8 populations and improves CAR-T therapy outcome.

Foskolou, Iosifina P; Barbieri, Laura; Vernet, Aude et al. · 2023

Full title: The S enantiomer of 2-hydroxyglutarate increases central memory CD8 populations and improves CAR-T therapy outcome.

DOI: https://www.repository.cam.ac.uk/handle/1810/347600

Thesis

Computational Fluid Dynamics Simulations of Single-Use Bioreactors for the Scale-Up of Cell Culture Processes

Kreitmayer, Diana · 2022

Full title: Computational Fluid Dynamics Simulations of Single-Use Bioreactors for the Scale-Up of Cell Culture Processes

Authors: Kreitmayer, Diana

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/32116/1/DissertationDianaKreitmayer.pdf

Thesis

Advancing Cell Culture Engineering Through Mechanistic Model Optimization

O'Brien, Conor · 2020

Full title: Advancing Cell Culture Engineering Through Mechanistic Model Optimization

Authors: O'Brien, Conor

DOI: http://hdl.handle.net/11299/215059

Thesis

Development of Biomaterials for Chimeric Antigen Receptor (CAR) T Cell Therapy

Olden, Brynn · 2018

Full title: Development of Biomaterials for Chimeric Antigen Receptor (CAR) T Cell Therapy

Authors: Olden, Brynn

DOI: http://hdl.handle.net/1773/42964

Thesis

Materials to enable and enhance T-cell immunotherapies

Zhang, Kongyu · 2021

Full title: Materials to enable and enhance T-cell immunotherapies

Authors: Zhang, Kongyu

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37370159

Thesis

Optimizing the Efficacy of Adoptive T Cell Transfers and CAR-T Therapies

Liu, Yutong · 2023

Full title: Optimizing the Efficacy of Adoptive T Cell Transfers and CAR-T Therapies

Authors: Liu, Yutong

DOI: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37375491

Thesis

Effects of Engineered Costimulation on the Function of T Cell Subsets

Boroughs, Angela C. · 2019

Full title: Effects of Engineered Costimulation on the Function of T Cell Subsets

Authors: Boroughs, Angela C.

DOI: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41121316

Thesis

Hydrodynamics considerations in cells systems from ocean flow to perfusion cultivation process

Zhan, Caijuan · 2019

Full title: Hydrodynamics considerations in cells systems from ocean flow to perfusion cultivation process

Authors: Zhan, Caijuan

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-252023

Thesis

Improvement of adoptive T-cell therapy for Cancer

Jin, Chuan · 2016

Full title: Improvement of adoptive T-cell therapy for Cancer

Authors: Jin, Chuan

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-300210

Thesis

High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

Zhang, Ye · 2017

Full title: High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

Authors: Zhang, Ye

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-207600

Thesis

Advanced Process Development in Gene and Cell Therapies

Ladd, Brian · 2025

Full title: Advanced Process Development in Gene and Cell Therapies

Authors: Ladd, Brian

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-360154

Thesis

CD19-targeting CAR T Cells for Treatment of B Cell Malignancies : From Bench to Bedside

Karlsson, Hannah · 2014

Full title: CD19-targeting CAR T Cells for Treatment of B Cell Malignancies : From Bench to Bedside

Authors: Karlsson, Hannah

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-232638

Thesis

TCR engineered T cell therapy from concepts to clinic

Kierkels, G.J.J. · 2019

Full title: TCR engineered T cell therapy from concepts to clinic

Authors: Kierkels, G.J.J.

DOI: https://dspace.library.uu.nl/handle/1874/379914

Thesis

Tackling major hurdles in cell therapy translational research: Different products, common challenges

Mfarrej, Bechara · 2019

Full title: Tackling major hurdles in cell therapy translational research: Different products, common challenges

Authors: Mfarrej, Bechara

DOI: https://dspace.library.uu.nl/handle/1874/386445

Thesis

Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis

Characterization of the down regulation of antibody production in high cell density perfusion culture

Morrill, Joyce Catherine · 2006

Full title: Characterization of the down regulation of antibody production in high cell density perfusion culture

Authors: Morrill, Joyce Catherine

DOI: http://hdl.handle.net/1721.1/32602

Thesis

Comparison of the growth and monoclonal antibody production of suspended mammalian cells in three perfusion systems

Hufford, Kathy (Kathy E.) · 2008

Full title: Comparison of the growth and monoclonal antibody production of suspended mammalian cells in three perfusion systems

Authors: Hufford, Kathy (Kathy E.)

DOI: http://hdl.handle.net/1721.1/39921

Thesis

Multiphase modelling of tissue growth in dynamic culture conditions

O'Dea, Reuben · 2008

Full title: Multiphase modelling of tissue growth in dynamic culture conditions

Authors: O'Dea, Reuben

DOI: https://eprints.nottingham.ac.uk/10446/1/thesis.pdf

Thesis

Micro-bioreactor design for Chinese hamster ovary cells

Goh, Shireen · 2013

Full title: Micro-bioreactor design for Chinese hamster ovary cells

Authors: Goh, Shireen

DOI: http://hdl.handle.net/1721.1/82368

Thesis

Continuum modelling of cell growth and nutrient transport in a perfusion bioreactor

Shakeel, Muhammad · 2011

Full title: Continuum modelling of cell growth and nutrient transport in a perfusion bioreactor

Authors: Shakeel, Muhammad

DOI: https://eprints.nottingham.ac.uk/11772/1/Final_thesis_2011.pdf

Thesis

White-Box Approaches to Cell Culture Media Optimization for Cultivated Meat

O'Neill, Edward N · 2024

Full title: White-Box Approaches to Cell Culture Media Optimization for Cultivated Meat

Authors: O'Neill, Edward N

DOI: https://escholarship.org/uc/item/9920t5d7

Thesis

Mathematical Modelling and Computational Simulation of in vitro Tissue Culture Processes

Hossain, Md Shakhawath · 2015

Full title: Mathematical Modelling and Computational Simulation of in vitro Tissue Culture Processes

Authors: Hossain, Md Shakhawath

DOI: http://hdl.handle.net/10388/ETD-2015-07-2131

Thesis

Fibrer-based bioreactor systems in Mammalian cell culture and tissue engineering Human Trophoblast cells /

Ma, Teng · 1999

Full title: Fibrer-based bioreactor systems in Mammalian cell culture and tissue engineering Human Trophoblast cells /

Authors: Ma, Teng

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1488188894442926

Thesis

Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Cosenza, Zachary Anthony · 2022

Full title: Sequential Learning Methods for the Experimental Optimization of Cell Culture Media for Cellular Agriculture

Authors: Cosenza, Zachary Anthony

DOI: https://escholarship.org/uc/item/119489fc

Thesis

Study of Hydrodynamics Due to Turbulent Mixing in Animal Cell Microcarrier Bioreactors /

Venkat, Raghavan V. · 1995

Full title: Study of Hydrodynamics Due to Turbulent Mixing in Animal Cell Microcarrier Bioreactors /

Authors: Venkat, Raghavan V.

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1487931512619511

Thesis

Vývoj nových postupů léčby B buněčných malignit pomocí imunoterapie založené na geneticky modifikovaných T lymfocytech

Novotná, Natálie · 2023

Full title: Vývoj nových postupů léčby B buněčných malignit pomocí imunoterapie založené na geneticky modifikovaných T lymfocytech

Authors: Novotná, Natálie

DOI: http://hdl.handle.net/20.500.11956/185118

Thesis

Enhancing Anti-tumor Efficacy and Improving Manufacturing of Chimeric Antigenic Receptor T Cells

Štach, Martin · 2025

Full title: Enhancing Anti-tumor Efficacy and Improving Manufacturing of Chimeric Antigenic Receptor T Cells

Authors: Štach, Martin

DOI: http://hdl.handle.net/20.500.11956/195993

Thesis

Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission

Bai, Zhiliang; Feng, Bing; McClory, Susan E. et al. · 2025

Full title: Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission

DOI: https://infoscience.epfl.ch/handle/20.500.14299/243828

Thesis

OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up

Tissot, Stéphanie · 2011

Full title: OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up

Authors: Tissot, Stéphanie

DOI: https://infoscience.epfl.ch/handle/20.500.14299/68752

Thesis

Characterization of the mechanism of action of spin-filters for animal cell perfusion cultures

Vallez-Chetreanu, Florentina · 2006

Full title: Characterization of the mechanism of action of spin-filters for animal cell perfusion cultures

Authors: Vallez-Chetreanu, Florentina

DOI: https://infoscience.epfl.ch/handle/20.500.14299/224152

Thesis

ELUCIDATING MAMMALIAN CELL METABOLISM USING ‘OMICS TO ENHANCE BIOPROCESS CAPABILITIES

Dhara, Venkata Gayatri · 2022

Full title: ELUCIDATING MAMMALIAN CELL METABOLISM USING ‘OMICS TO ENHANCE BIOPROCESS CAPABILITIES

Authors: Dhara, Venkata Gayatri

DOI: http://jhir.library.jhu.edu/handle/1774.2/66775

Thesis

FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

Chan, JD; Scheffler, CM; Munoz, I et al. · 2024

Full title: FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

DOI: https://hdl.handle.net/11343/345521

Thesis

Optimization of chimeric antigen receptor (CAR) therapy

Fräßle, Simon Paul · 2021

Full title: Optimization of chimeric antigen receptor (CAR) therapy

Authors: Fräßle, Simon Paul

DOI: https://mediatum.ub.tum.de/1546230

Thesis

Expansion of human induced pluripotent stem cells (hiPSCs) in 3D bioreactors for extracorporeal liver support

Greuel, Selina · 2020

Full title: Expansion of human induced pluripotent stem cells (hiPSCs) in 3D bioreactors for extracorporeal liver support

Authors: Greuel, Selina

DOI: https://refubium.fu-berlin.de/handle/fub188/26868

Thesis

The non-viral production of Chimeric Antigen Receptor T-cells for B-cell haematological malignancies

Dubosq, Ming-Celine · 2020

Full title: The non-viral production of Chimeric Antigen Receptor T-cells for B-cell haematological malignancies

Authors: Dubosq, Ming-Celine

DOI: https://hdl.handle.net/2123/23170

Thesis

CD19 specific chimeric antigen receptor expression optimisation in human T-cells using the piggyBac transposase system

Bilmon, Ian Andrew · 2015

Full title: CD19 specific chimeric antigen receptor expression optimisation in human T-cells using the piggyBac transposase system

Authors: Bilmon, Ian Andrew

DOI: http://hdl.handle.net/2123/14060

Thesis

Cultivo de celulas hematopeyeticas humanas suspendidasen reactores instrumentados : utilidad de la velocidad de consumo de oxigeno y el potencial redox

Leon Rodriguez, Antonio de · 2021

Full title: Cultivo de celulas hematopeyeticas humanas suspendidasen reactores instrumentados : utilidad de la velocidad de consumo de oxigeno y el potencial redox

Authors: Leon Rodriguez, Antonio de

DOI: https://hdl.handle.net/20.500.14330/TES01000273766

Thesis

Development of a prototype hollow fibre bioreactor system

Camacho, Fernando · 1998

Full title: Development of a prototype hollow fibre bioreactor system

Authors: Camacho, Fernando

DOI: http://hdl.handle.net/1959.4/57319

Thesis

Vesículas extracelulares derivadas de células CAR-T: produção e caracterização em modelos experimentais e clínicos

Corveloni, Amanda Cristina · 2025

Full title: Vesículas extracelulares derivadas de células CAR-T: produção e caracterização em modelos experimentais e clínicos

Authors: Corveloni, Amanda Cristina

DOI: https://www.teses.usp.br/teses/disponiveis/17/17153/tde-03112025-171718/

Thesis

Ex vivo expansion of haematopoietic stem cells in a HFBR

Doran, Michael · 2006

Full title: Ex vivo expansion of haematopoietic stem cells in a HFBR

Authors: Doran, Michael

DOI: http://hdl.handle.net/1959.4/100312

Thesis

Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo

Picanço-Castro, Virgínia · 2023

Full title: Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo

Authors: Picanço-Castro, Virgínia

DOI: https://doi.org/10.3389/fimmu.2023.1226518

Thesis

Otimização de uma plataforma baseada na edição gênica por CRISPR/Cas9 para a produção de células T alogênicas expressando o receptor quimérico de antígeno (CAR)

Souza, Lucas Eduardo Botelho · 2024

Full title: Otimização de uma plataforma baseada na edição gênica por CRISPR/Cas9 para a produção de células T alogênicas expressando o receptor quimérico de antígeno (CAR)

Authors: Souza, Lucas Eduardo Botelho

DOI: https://doi.org/10.11606/D.17.2024.tde-13052024-144054

Thesis

Cytokines as an important player in the context of CAR-T cell therapy for cancer: their role in tumor immunomodulation, manufacture, and clinical implications

Guerino-Cunha, Renato Luiz · 2022

Full title: Cytokines as an important player in the context of CAR-T cell therapy for cancer: their role in tumor immunomodulation, manufacture, and clinical implications

Authors: Guerino-Cunha, Renato Luiz

DOI: https://doi.org/10.3389/fimmu.2022.947648

Thesis

Adoptive T Cell Therapy for Treatment of Metastatic Melanoma

Sadeghi, Arian · 2011

Full title: Adoptive T Cell Therapy for Treatment of Metastatic Melanoma

Authors: Sadeghi, Arian

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-143698

Thesis

GMP-grade manufacturing of T cells engineered to express a defined γδTCR

Straetemans, Trudy; Kierkels, Guido J.J.; Doorn, Ruud et al. · 2018

Full title: GMP-grade manufacturing of T cells engineered to express a defined γδTCR

DOI: https://dspace.library.uu.nl/handle/1874/365453

Thesis

Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

Wachsmann, Tassilo L A; Wouters, Anne K; Remst, Dennis F G et al. · 2022

Full title: Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

DOI: https://dspace.library.uu.nl/handle/1874/445619

Thesis

Regulatory perspective on in vitro potency assays for human T cells used in anti-tumor immunotherapy

de Wolf, Charlotte; van de Bovenkamp, Marja; Hoefnagel, Marcel C · 2018

Full title: Regulatory perspective on in vitro potency assays for human T cells used in anti-tumor immunotherapy

Authors: de Wolf, Charlotte; van de Bovenkamp, Marja; Hoefnagel, Marcel C

DOI: https://dspace.library.uu.nl/handle/1874/376475

Thesis

Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe et al. · 2016

Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

Authors: López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe; Carrillo-Cocom, Leydi Maribel; Rocha-Pizaña, María del Refugio; Alvarez, Mario Moises

DOI: http://hdl.handle.net/1721.1/105504

Thesis

Rapid tissue prototyping with micro-organospheres

Wang, Zhaohui; Boretto, Matteo; Millen, Rosemary et al. · 2022

Full title: Rapid tissue prototyping with micro-organospheres

DOI: https://dspace.library.uu.nl/handle/1874/447775

Thesis

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

Tang, Li; Zheng, Yiran; Melo, Mariane Bandeira et al. · 2019

Full title: Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

Authors: Tang, Li; Zheng, Yiran; Melo, Mariane Bandeira; Mabardi, Llian; Castaño, Ana P; Xie, Yu-Qing; Li, Na; Kudchodkar, Sagar B; Wong, Hing C; Jeng, Emily K; Maus, Marcela V; Irvine, Darrell J

DOI: http://hdl.handle.net/1721.1/120102

Thesis

Billion-Scale Expansion of Functional hiPSC-Derived Cardiomyocytes in Bioreactors Through Oxygen Control and Continuous Wnt Activation

Vicente, Pedro; Inocêncio, Lara R.; Ullate-Agote, Asier et al. · 2025

Full title: Billion-Scale Expansion of Functional hiPSC-Derived Cardiomyocytes in Bioreactors Through Oxygen Control and Continuous Wnt Activation

DOI: https://dspace.library.uu.nl/handle/1874/460379

Thesis

Biomanufacturing for clinically advanced cell therapies

Aijaz, Ayesha; Li, Matthew; Smith, David et al. · 2019

Full title: Biomanufacturing for clinically advanced cell therapies

DOI: https://hdl.handle.net/1721.1/121979

Thesis

Sense-and-Respond Payload Delivery Using a Novel Antigen-Inducible Promoter Improves Suboptimal CAR-T Activation

Guo, Tingxi; Ma, Dacheng; Lu, Timothy K · 2022

Full title: Sense-and-Respond Payload Delivery Using a Novel Antigen-Inducible Promoter Improves Suboptimal CAR-T Activation

Authors: Guo, Tingxi; Ma, Dacheng; Lu, Timothy K

DOI: https://hdl.handle.net/1721.1/143767

Thesis

Miniature auto‐perfusion bioreactor system with spiral microfluidic cell retention device

Yin, Lu; Au, Wen Y.; Yu, Chia C. et al. · 2022

Full title: Miniature auto‐perfusion bioreactor system with spiral microfluidic cell retention device

Authors: Yin, Lu; Au, Wen Y.; Yu, Chia C.; Kwon, Taehong; Lai, Zhangxing; Shang, Menglin; Warkiani, Majid E.; Rosche, Roger; Lim, Chwee T.; Han, Jongyoon

DOI: https://hdl.handle.net/1721.1/140309.2

Thesis

A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

Boroughs, Angela C; Larson, Rebecca C; Marjanovic, Nemanja D et al. · 2023

Full title: A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

DOI: https://hdl.handle.net/1721.1/147057

Thesis

Transport and shear in a microfluidic membrane bilayer device for cell culture

Inamdar, Niraj K.; Griffith, Linda G.; Borenstein, Jeffrey T. · 2012

Full title: Transport and shear in a microfluidic membrane bilayer device for cell culture

Authors: Inamdar, Niraj K.; Griffith, Linda G.; Borenstein, Jeffrey T.

DOI: http://hdl.handle.net/1721.1/75775

Thesis

Transport Model for Microfluidic Device for Cell Culture and Tissue Development

Inamdar, Niraj K.; Griffith, Linda G.; Borenstein, Jeffrey T. · 2013

Full title: Transport Model for Microfluidic Device for Cell Culture and Tissue Development

Authors: Inamdar, Niraj K.; Griffith, Linda G.; Borenstein, Jeffrey T.

DOI: http://hdl.handle.net/1721.1/76193

Thesis

Qualitatively Different T Cell Phenotypic Responses to IL-2 versus IL-15 Are Unified by Identical Dependences on Receptor Signal Strength and Duration

Arneja, Abhinav; Johnson, Hannah; Gabrovsek, Laura et al. · 2015

Full title: Qualitatively Different T Cell Phenotypic Responses to IL-2 versus IL-15 Are Unified by Identical Dependences on Receptor Signal Strength and Duration

Authors: Arneja, Abhinav; Johnson, Hannah; Gabrovsek, Laura; White, Forest M.; Lauffenburger, Douglas A

DOI: http://hdl.handle.net/1721.1/99480

Thesis

New Strategy for Promoting Vascularization in Tumor Spheroids in a Microfluidic Assay

Wan, Zhengpeng; Floryan, Marie A; Coughlin, Mark F et al. · 2023

Full title: New Strategy for Promoting Vascularization in Tumor Spheroids in a Microfluidic Assay

Authors: Wan, Zhengpeng; Floryan, Marie A; Coughlin, Mark F; Zhang, Shun; Zhong, Amy X; Shelton, Sarah E; Wang, Xun; Xu, Chenguang; Barbie, David A; Kamm, Roger D

DOI: https://hdl.handle.net/1721.1/148045

Thesis

Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel et al. · 2025

Full title: Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Authors: Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel; Dang, Brendan; Wolffe, Lenna A; Atari, Adel; Tseng, Yuen-Yi; Love, J Christopher

DOI: https://hdl.handle.net/1721.1/163220

Thesis

Understanding T cell phenotype for the design of effective chimeric antigen receptor T cell therapies

Tantalo, DGM; Oliver, AJ; Von Scheidt, B et al. · 2021

Full title: Understanding T cell phenotype for the design of effective chimeric antigen receptor T cell therapies

Authors: Tantalo, DGM; Oliver, AJ; Von Scheidt, B; Harrison, AJ; Mueller, SN; Kershaw, MH; Slaney, CY

DOI: https://hdl.handle.net/11343/278368

Thesis

Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture

Shariatzadeh, M; Lopes, AG; Glen, KE et al. · 2021

Full title: Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture

Authors: Shariatzadeh, M; Lopes, AG; Glen, KE; Sinclair, A; Thomas, RJ

DOI: https://hdl.handle.net/11343/289743

Thesis

Predictions for optimal mitigation of paracrine inhibitory signalling in haemopoietic stem cell cultures

Berry, JD; Godara, P; Liovic, P et al. · 2018

Full title: Predictions for optimal mitigation of paracrine inhibitory signalling in haemopoietic stem cell cultures

Authors: Berry, JD; Godara, P; Liovic, P; Haylock, DN

DOI: https://hdl.handle.net/11343/208852

Thesis

Manufacturing T cells in hollow fiber membrane bioreactors changes their programming and enhances their potency

Yoo, SM; Lau, VWC; Aarts, C et al. · 2022

Full title: Manufacturing T cells in hollow fiber membrane bioreactors changes their programming and enhances their potency

Authors: Yoo, SM; Lau, VWC; Aarts, C; Bojovic, B; Steinberg, G; Hammill, JA; Dvorkin-Gheva, A; Ghosh, R; Bramson, JL

DOI: https://hdl.handle.net/11343/305190

Thesis

CD4+ chimeric antigen receptor T cells in for the long journey

Chen, AXY; Derrick, EB; Beavis, PA et al. · 2023

Full title: CD4+ chimeric antigen receptor T cells in for the long journey

Authors: Chen, AXY; Derrick, EB; Beavis, PA; House, IG

DOI: https://hdl.handle.net/11343/336424

Thesis

EARLY-PHENOTYPE LEWIS Y CAR-T CELLS PERSIST BETTER IN VIVO AND INDUCE SOLID TUMOR REGRESSION IN COMBINATION WITH ANTI-PD1

Meyran, D; Zhu, J; Butler, J et al. · 2021

Full title: EARLY-PHENOTYPE LEWIS Y CAR-T CELLS PERSIST BETTER IN VIVO AND INDUCE SOLID TUMOR REGRESSION IN COMBINATION WITH ANTI-PD1

Authors: Meyran, D; Zhu, J; Butler, J; Macdonald, S; Tantalo, D; Thio, N; Sek, K; Ekert, P; Kershaw, M; Trapani, J; Darcy, P; Neeson, P

DOI: https://hdl.handle.net/11343/273975

Thesis

IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors

Giuffrida, L; Sek, K; Henderson, MA et al. · 2023

Full title: IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors

DOI: https://hdl.handle.net/11343/331896

Thesis

Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain

Vorri, SC; Holl, NJ; Leeming, M et al. · 2025

Full title: Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain

Authors: Vorri, SC; Holl, NJ; Leeming, M; Apostolova, P; Marple, A; Ravich, JW; Canbaz, A; Rahnama, R; Choe, J; Modi, A; Fearnow, AD; Walsh, STR; Pearce, EL; Varadhan, R; Bonifant, CL

DOI: https://hdl.handle.net/11343/358519

Thesis

MECHANOCULTURE – Applications of dynamic pressure in manufacturing cell therapies

Hallas, Joe; Al-Maslemani, Noor; Janvier, Adam et al. · 2019

Full title: MECHANOCULTURE – Applications of dynamic pressure in manufacturing cell therapies

Authors: Hallas, Joe; Al-Maslemani, Noor; Janvier, Adam; Hoettges, Kai; Henstock, James

DOI: https://livrepository.liverpool.ac.uk/3071579/1/James%20Henstock%20mechanoculture%20TERMIS%20AP.pdf

Thesis

Generation of stable suspension producer cell lines for serum-free lentivirus production

Klimpel, M; Terrao, M; Bräuer, M et al. · 2024

Full title: Generation of stable suspension producer cell lines for serum-free lentivirus production

DOI: https://hdl.handle.net/11343/351064

Thesis

A Perfusion Bioreactor System for Cell Seeding and Oxygen-Controlled Cultivation of Three-Dimensional Cell Cultures

Schmid, Jakob; Schwarz, Sascha; Meier-Staude, Robert et al. · 2018

Full title: A Perfusion Bioreactor System for Cell Seeding and Oxygen-Controlled Cultivation of Three-Dimensional Cell Cultures

Authors: Schmid, Jakob;Schwarz, Sascha;Meier-Staude, Robert;Sudhop, Stefanie;Clausen-Schaumann, Hauke;Schieker, Matthias;Huber, Robert

DOI: https://mediatum.ub.tum.de/1525549

Thesis

Optimization of Fermentation and Freeze-Drying Processes to Enhance the Productivity and Stability of a Probiotic, Lactobacillus Salivarius I 24

Lim, Chin Ming · 2006

Full title: Optimization of Fermentation and Freeze-Drying Processes to Enhance the Productivity and Stability of a Probiotic, Lactobacillus Salivarius I 24

Authors: Lim, Chin Ming

DOI: http://psasir.upm.edu.my/id/eprint/5354/1/IB_2006_10.pdf

Thesis

MODEL COMPARISON TO DESCRIBE BHK-21 CELL GROWTH AND METABOLISM IN STIRRED TANK BIOREACTORS OPERATED IN BATCH MODE

Sartori, Roger [UNESP]; Leme, Jaci; Caricati, Celso Pereira et al. · 2019

Full title: MODEL COMPARISON TO DESCRIBE BHK-21 CELL GROWTH AND METABOLISM IN STIRRED TANK BIOREACTORS OPERATED IN BATCH MODE

Authors: Sartori, Roger [UNESP]; Leme, Jaci; Caricati, Celso Pereira; Tonso, Aldo; Fernandez Nunez, Eutimio Gustavo [UNESP]

DOI: http://dx.doi.org/10.1590/0104-6632.20180352s20160592

Thesis

Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing

Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP] et al. · 2019

Full title: Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing

Authors: Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP]; Deffune, Elenice; Suazo, Cláudio Alberto Torres

DOI: http://dx.doi.org/10.1590/0104-6632.20180352s20160463

Thesis

3D Systems for Immune cells culture and their applications in Immunotherapy

Pérez del Río, Eduardo · 2020

Full title: 3D Systems for Immune cells culture and their applications in Immunotherapy

Authors: Pérez del Río, Eduardo

DOI: http://hdl.handle.net/10803/670158

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Full title: us-2013280221-a1

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us-2021115402-a1

· 2021

Full title: us-2021115402-a1

Patent

us-2021108176-a1

· 2021

Full title: us-2021108176-a1

Patent

us-2021115373-a1

· 2021

Full title: us-2021115373-a1

Patent

us-2021094994-a1

· 2021

Full title: us-2021094994-a1

Patent

us-2021115372-a1

· 2021

Full title: us-2021115372-a1

Patent

us-2021106625-a1

· 2021

Full title: us-2021106625-a1

Patent

us-2021115375-a1

· 2021

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us-2024060030-a1

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us-2024076617-a1

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us-2024110152-a1

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us-2024075064-a1

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us-2024108705-a1

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us-2024052311-a1

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us-2024139393-a1

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us-2024108722-a1

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us-2024132844-a1

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us-2024200009-a1

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us-2024150773-a1

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us-2024228569-a1

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us-2024226158-a9

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us-2024226154-a9

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us-2024191192-a1

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us-2024191190-a1

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us-2024209050-a1

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us-2024228964-a9

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us-2024228963-a1

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Full title: us-2024228963-a1

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us-2024240146-a1

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Full title: us-2024240146-a1

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us-2024318137-a1

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us-2024325538-a1

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us-2024277764-a1

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Full title: us-2024277764-a1

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us-2024307441-a1

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Full title: us-2024307441-a1

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us-2024309102-a1

· 2024

Full title: us-2024309102-a1

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us-2024316106-a1

· 2024

Full title: us-2024316106-a1

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us-2024376430-a1

· 2024

Full title: us-2024376430-a1

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us-2024335472-a1

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us-2024376416-a1

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us-2024382593-a1

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us-2024415965-a1

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us-2024398695-a1

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us-2024424097-a1

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us-2024384211-a1

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us-2024398946-a1

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us-2024392225-a1

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us-2025027042-a1

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us-2024398913-a1

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Full title: us-2024398913-a1

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us-2024368625-a1

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us-2025002851-a1

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us-2025017966-a1

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us-2024408199-a1

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Full title: us-2024408199-a1

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us-2025019655-a1

· 2025

Full title: us-2025019655-a1

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us-2024423174-a1

· 2024

Full title: us-2024423174-a1

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us-2025002850-a1

· 2025

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us-2025082683-a1

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us-2025043011-a1

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us-2025066810-a1

· 2025

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us-2025034500-a1

· 2025

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us-2025073228-a1

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us-2025092362-a1

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us-2025121009-a1

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us-2025101379-a1

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us-2025121008-a1

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us-2025134931-a1

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Full title: us-2025134931-a1

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us-2025122472-a1

· 2025

Full title: us-2025122472-a1

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us-2025144215-a1

· 2025

Full title: us-2025144215-a1

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us-2025154465-a1

· 2025

Full title: us-2025154465-a1

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us-2025179404-a1

· 2025

Full title: us-2025179404-a1

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us-2025171731-a1

· 2025

Full title: us-2025171731-a1

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us-2025145929-a1

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Full title: us-2025145929-a1

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us-2025188413-a1

· 2025

Full title: us-2025188413-a1

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us-2025213615-a1

· 2025

Full title: us-2025213615-a1

Patent

us-2025207095-a1

· 2025

Full title: us-2025207095-a1

Patent

us-2025206804-a1

· 2025

Full title: us-2025206804-a1

Patent

us-10533156-b2

· 2020

Full title: us-10533156-b2

Patent

us-10563172-b2

· 2020

Full title: us-10563172-b2

Patent

us-10479975-b2

· 2019

Full title: us-10479975-b2

Patent

us-10646517-b2

· 2020

Full title: us-10646517-b2

Patent

us-10695372-b2

· 2020

Full title: us-10695372-b2

Patent

us-10501539-b2

· 2019

Full title: us-10501539-b2

Patent

us-10363273-b2

· 2019

Full title: us-10363273-b2

Patent

us-10548921-b2

· 2020

Full title: us-10548921-b2

Patent

us-10471098-b2

· 2019

Full title: us-10471098-b2

Patent

us-10640570-b2

· 2020

Full title: us-10640570-b2

Patent

us-10639330-b2

· 2020

Full title: us-10639330-b2

Patent

us-10653723-b1

· 2020

Full title: us-10653723-b1

Patent

us-10894063-b2

· 2021

Full title: us-10894063-b2

Patent

us-10946044-b2

· 2021

Full title: us-10946044-b2

Patent

us-10953046-b2

· 2021

Full title: us-10953046-b2

Patent

us-10829735-b2

· 2020

Full title: us-10829735-b2

Patent

us-10933094-b2

· 2021

Full title: us-10933094-b2

Patent

us-10946045-b2

· 2021

Full title: us-10946045-b2

Patent

us-10925900-b2

· 2021

Full title: us-10925900-b2

Patent

us-11007226-b2

· 2021

Full title: us-11007226-b2

Patent

us-11040070-b2

· 2021

Full title: us-11040070-b2

Patent

us-10918667-b2

· 2021

Full title: us-10918667-b2

Patent

us-10953047-b2

· 2021

Full title: us-10953047-b2

Patent

us-10918666-b2

· 2021

Full title: us-10918666-b2

Patent

us-11034763-b2

· 2021

Full title: us-11034763-b2

Patent

us-11007225-b1

· 2021

Full title: us-11007225-b1

Patent

us-11052115-b2

· 2021

Full title: us-11052115-b2

Patent

us-11034933-b2

· 2021

Full title: us-11034933-b2

Patent

us-11052112-b2

· 2021

Full title: us-11052112-b2

Patent

us-10905718-b2

· 2021

Full title: us-10905718-b2

Patent

us-11103533-b2

· 2021

Full title: us-11103533-b2

Patent

us-11168304-b2

· 2021

Full title: us-11168304-b2

Patent

us-11052116-b2

· 2021

Full title: us-11052116-b2

Patent

us-11083752-b2

· 2021

Full title: us-11083752-b2

Patent

us-11168303-b2

· 2021

Full title: us-11168303-b2

Patent

us-11111301-b2

· 2021

Full title: us-11111301-b2

Patent

us-11123369-b2

· 2021

Full title: us-11123369-b2

Patent

us-10463697-b2

· 2019

Full title: us-10463697-b2

Patent

us-11202803-b1

· 2021

Full title: us-11202803-b1

Patent

us-11268058-b2

· 2022

Full title: us-11268058-b2

Patent

us-11268066-b2

· 2022

Full title: us-11268066-b2

Patent

us-11202804-b2

· 2021

Full title: us-11202804-b2

Patent

us-11254913-b1

· 2022

Full title: us-11254913-b1

Patent

us-11304979-b2

· 2022

Full title: us-11304979-b2

Patent

us-11273181-b2

· 2022

Full title: us-11273181-b2

Patent

us-11273180-b2

· 2022

Full title: us-11273180-b2

Patent

us-11337998-b2

· 2022

Full title: us-11337998-b2

Patent

us-11241456-b2

· 2022

Full title: us-11241456-b2

Patent

us-11230699-b2

· 2022

Full title: us-11230699-b2

Patent

us-11344579-b2

· 2022

Full title: us-11344579-b2

Patent

us-11434459-b2

· 2022

Full title: us-11434459-b2

Patent

us-11013770-b1

· 2021

Full title: us-11013770-b1

Patent

us-11447732-b2

· 2022

Full title: us-11447732-b2

Patent

us-11464800-b2

· 2022

Full title: us-11464800-b2

Patent

us-11371018-b2

· 2022

Full title: us-11371018-b2

Patent

us-11291687-b2

· 2022

Full title: us-11291687-b2

Patent

us-11384337-b2

· 2022

Full title: us-11384337-b2

Patent

us-11447745-b2

· 2022

Full title: us-11447745-b2

Patent

us-11524988-b2

· 2022

Full title: us-11524988-b2

Patent

us-11517592-b1

· 2022

Full title: us-11517592-b1

Patent

us-11560547-b2

· 2023

Full title: us-11560547-b2

Patent

us-11453719-b2

· 2022

Full title: us-11453719-b2

Patent

us-11529372-b1

· 2022

Full title: us-11529372-b1

Patent

us-11541077-b2

· 2023

Full title: us-11541077-b2

Patent

us-11464801-b2

· 2022

Full title: us-11464801-b2

Patent

us-11629332-b2

· 2023

Full title: us-11629332-b2

Patent

us-11613574-b2

· 2023

Full title: us-11613574-b2

Patent

us-11624046-b2

· 2023

Full title: us-11624046-b2

Patent

us-11479755-b2

· 2022

Full title: us-11479755-b2

Patent

us-11717538-b2

· 2023

Full title: us-11717538-b2

Patent

us-11590169-b1

· 2023

Full title: us-11590169-b1

Patent

us-11524034-b2

· 2022

Full title: us-11524034-b2

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us-11655452-b2

· 2023

Full title: us-11655452-b2

Patent

us-11680103-b2

· 2023

Full title: us-11680103-b2

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us-11708408-b2

· 2023

Full title: us-11708408-b2

Patent

us-11723923-b2

· 2023

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us-11781100-b2

· 2023

Full title: us-11781100-b2

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us-11702634-b2

· 2023

Full title: us-11702634-b2

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us-11766474-b2

· 2023

Full title: us-11766474-b2

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us-10577585-b2

· 2020

Full title: us-10577585-b2

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us-11781113-b2

· 2023

Full title: us-11781113-b2

Patent

us-11857572-b2

· 2024

Full title: us-11857572-b2

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us-11821002-b2

· 2023

Full title: us-11821002-b2

Patent

us-11905515-b2

· 2024

Full title: us-11905515-b2

Patent

us-11851678-b2

· 2023

Full title: us-11851678-b2

Patent

us-2017260506-a1

· 2017

Full title: us-2017260506-a1

Patent

us-2021348126-a1

· 2021

Full title: us-2021348126-a1

Patent

us-2022186185-a1

· 2022

Full title: us-2022186185-a1

Patent

us-2022387530-a1

· 2022

Full title: us-2022387530-a1

Patent

us-2025319128-a1

· 2025

Full title: us-2025319128-a1

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