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Preclinical Research And Cell Line Protocols For B

cheasleylab

1. Documents

52
12 papers 37 patents 3 theses
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Full text available

Paper First-in-Human Phase I Study of Aprutumab Ixadotin, a Fibroblast Growth Factor Receptor 2 Antibody-Drug Conjugate (BAY 1187982) in Patients with Advanced Cancer.
Kim, Sung-Bae; Meric-Bernstam, Funda; Kalyan, Aparna et al. · 2019 · Targeted oncology · DOI
Full title: First-in-Human Phase I Study of Aprutumab Ixadotin, a Fibroblast Growth Factor Receptor 2 Antibody-Drug Conjugate (BAY 1187982) in Patients with Advanced Cancer.
Authors: Kim, Sung-Bae; Meric-Bernstam, Funda; Kalyan, Aparna; Babich, Aleksei; Liu, Rong; Tanigawa, Takahiko; Sommer, Anette; Osada, Motonobu; Reetz, Frank; Laurent, Dirk; Wittemer-Rump, Sabine; Berlin, Jordan
Year: 2019
Venue: Targeted oncology
Paper Generation of high-affinity, internalizing anti-FGFR2 single-chain variable antibody fragment fused with Fc for targeting gastrointestinal cancers.
Borek, Aleksandra; Sokolowska-Wedzina, Aleksandra; Chodaczek, Grzegorz et al. · 2018 · PloS one · DOI
Full title: Generation of high-affinity, internalizing anti-FGFR2 single-chain variable antibody fragment fused with Fc for targeting gastrointestinal cancers.
Authors: Borek, Aleksandra; Sokolowska-Wedzina, Aleksandra; Chodaczek, Grzegorz; Otlewski, Jacek
Year: 2018
Venue: PloS one
Thesis Clinical Developments and Challenges in Treating FGFR2-Driven Gastric Cancer
Lau, DK; Collin, JP; Mariadason, JM · 2024 · University of Melbourne · DOI
Full title: Clinical Developments and Challenges in Treating FGFR2-Driven Gastric Cancer
Authors: Lau, DK; Collin, JP; Mariadason, JM
Year: 2024
Venue: University of Melbourne
Patent us-10138301-b2
· 2018
Full title: us-10138301-b2
Year: 2018
Patent us-11406720-b2
· 2022
Full title: us-11406720-b2
Year: 2022
Patent us-11235059-b2
· 2022
Full title: us-11235059-b2
Year: 2022
Patent us-11866502-b2
· 2024
Full title: us-11866502-b2
Year: 2024
Patent us-2004014024-a1
· 2004
Full title: us-2004014024-a1
Year: 2004
Patent us-2010048620-a1
· 2010
Full title: us-2010048620-a1
Year: 2010
Patent us-2010047251-a1
· 2010
Full title: us-2010047251-a1
Year: 2010
Patent us-2012214829-a1
· 2012
Full title: us-2012214829-a1
Year: 2012
Patent us-2014140995-a1
· 2014
Full title: us-2014140995-a1
Year: 2014
Patent us-2015023989-a1
· 2015
Full title: us-2015023989-a1
Year: 2015
Patent us-2016096876-a1
· 2016
Full title: us-2016096876-a1
Year: 2016
Patent us-2016339100-a1
· 2016
Full title: us-2016339100-a1
Year: 2016
Patent us-2017349643-a1
· 2017
Full title: us-2017349643-a1
Year: 2017
Patent us-2021147812-a1
· 2021
Full title: us-2021147812-a1
Year: 2021
Patent us-2021293786-a1
· 2021
Full title: us-2021293786-a1
Year: 2021
Patent us-2022162323-a1
· 2022
Full title: us-2022162323-a1
Year: 2022
Patent us-2023055566-a1
· 2023
Full title: us-2023055566-a1
Year: 2023
Patent us-2024101683-a1
· 2024
Full title: us-2024101683-a1
Year: 2024
Patent us-2023242650-a1
· 2023
Full title: us-2023242650-a1
Year: 2023
Patent us-2024190973-a1
· 2024
Full title: us-2024190973-a1
Year: 2024
Patent us-2023052256-a1
· 2023
Full title: us-2023052256-a1
Year: 2023
Patent us-2025269016-a1
· 2025
Full title: us-2025269016-a1
Year: 2025
Patent us-2025243284-a1
· 2025
Full title: us-2025243284-a1
Year: 2025
Patent us-9506926-b2
· 2016
Full title: us-9506926-b2
Year: 2016
Patent us-8962655-b2
· 2015
Full title: us-8962655-b2
Year: 2015

Metadata only

Paper Abstract 245: Preclinical development of HDM2020, a novel ADC targeting FGFR2b, in gastric cancer (GC) and squamous non-small cell lung cancer (sq-NSCLC) xenograft models
Tingyang Wang; Liubin Guo; Kuan Lu et al. · 2025 · Cancer Research · DOI
Full title: Abstract 245: Preclinical development of HDM2020, a novel ADC targeting FGFR2b, in gastric cancer (GC) and squamous non-small cell lung cancer (sq-NSCLC) xenograft models
Authors: Tingyang Wang; Liubin Guo; Kuan Lu; Hao Pan; Yang Chen; Zhaoxing Yu; Yayun Zhao; Shengxing Zhao; Qingli We; Ruizhe Wang; Yan Xia; Hongwen Li; D. Liu
Year: 2025
Venue: Cancer Research
Paper New therapeutic target molecules for gastric and gastroesophageal junction cancer.
Kawakami, Hisato · 2024 · International journal of clinical oncology · DOI
Full title: New therapeutic target molecules for gastric and gastroesophageal junction cancer.
Authors: Kawakami, Hisato
Year: 2024
Venue: International journal of clinical oncology
Paper Abstract 4769: Characterization of novel humanized FGFR2b antibody-based ADCs site-specifically conjugated with topoisomerase I inhibitor payload in preclinical tumor models
Fei Teng; Huanhuan Guo; Hongjun Li et al. · 2025 · Cancer Research · DOI
Full title: Abstract 4769: Characterization of novel humanized FGFR2b antibody-based ADCs site-specifically conjugated with topoisomerase I inhibitor payload in preclinical tumor models
Authors: Fei Teng; Huanhuan Guo; Hongjun Li; Lizhi Qin; Xin-gang Yao; Lei Shi; Yi Gu; Xueming Qian
Year: 2025
Venue: Cancer Research
Paper Preclinical Combination Studies of an FGFR2 Targeted Thorium-227 Conjugate and the ATR Inhibitor BAY 1895344.
Wickstroem, Katrine; Hagemann, Urs B; Kristian, Alexander et al. · 2019 · International journal of radiation oncology, biology, physics · DOI
Full title: Preclinical Combination Studies of an FGFR2 Targeted Thorium-227 Conjugate and the ATR Inhibitor BAY 1895344.
Authors: Wickstroem, Katrine; Hagemann, Urs B; Kristian, Alexander; Ellingsen, Christine; Sommer, Anette; Ellinger-Ziegelbauer, Heidrun; Wirnitzer, Uta; Hagelin, Else-Marie; Larsen, Aasmund; Smeets, Roger; Bjerke, Roger M; Karlsson, Jenny; Ryan, Olav B; Wengner, Antje M; Linden, Lars; Mumberg, Dominik; Cuthbertson, Alan S
Year: 2019
Venue: International journal of radiation oncology, biology, physics
Paper SCR-A002, a novel FGFR2b-targeting antibody-drug-conjugate for solid tumors.
Yayuan Fu; Yuanjie Ge; Xiaohui Shao et al. · 2024 · Journal of Clinical Oncology · DOI
Full title: SCR-A002, a novel FGFR2b-targeting antibody-drug-conjugate for solid tumors.
Authors: Yayuan Fu; Yuanjie Ge; Xiaohui Shao; Qi Deng; Chunlei Xia; Renhong Tang
Year: 2024
Venue: Journal of Clinical Oncology
Paper Abstract 3778: Preclinical evaluation of BG-C137, a potential first-in-class FGFR2b-targeting ADC, for the treatment of FGFR2b-expressing cancer
Yibin Xu; Xiaolin Su; Qiming Xu et al. · 2025 · Cancer Research · DOI
Full title: Abstract 3778: Preclinical evaluation of BG-C137, a potential first-in-class FGFR2b-targeting ADC, for the treatment of FGFR2b-expressing cancer
Authors: Yibin Xu; Xiaolin Su; Qiming Xu; Mengran Qian; Tai-Zhe Zhang; Mei-Hsuan Tsai; Ruyue Ji; Junna Jiang; Bin Shao; Zhuang Yuan; Jiyuan Zhang; Xiaomin Song; Zhitao Wan; Xiao-Qiang Tang; Yue Wu; Charng-Sheng Tsai; Chichi Huang; Lai Wang; Zhirong Shen
Year: 2025
Venue: Cancer Research
Paper Preclinical Efficacy of the Auristatin-Based Antibody-Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors.
Sommer, Anette; Kopitz, Charlotte; Schatz, Christoph A et al. · 2016 · Cancer research · DOI
Full title: Preclinical Efficacy of the Auristatin-Based Antibody-Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors.
Authors: Sommer, Anette; Kopitz, Charlotte; Schatz, Christoph A; Nising, Carl F; Mahlert, Christoph; Lerchen, Hans-Georg; Stelte-Ludwig, Beatrix; Hammer, Stefanie; Greven, Simone; Schuhmacher, Joachim; Braun, Manuela; Zierz, Ruprecht; Wittemer-Rump, Sabine; Harrenga, Axel; Dittmer, Frank; Reetz, Frank; Apeler, Heiner; Jautelat, Rolf; Huynh, Hung; Ziegelbauer, Karl; Kreft, Bertolt
Year: 2016
Venue: Cancer research
Paper Abstract 2964: SCR-A002, a novel FGFR2b-targeting ADC for solid tumors
Yayuan Fu; Yuanjie Ge; Xiaohui Shao et al. · 2025 · Cancer Research · DOI
Full title: Abstract 2964: SCR-A002, a novel FGFR2b-targeting ADC for solid tumors
Authors: Yayuan Fu; Yuanjie Ge; Xiaohui Shao; Qi Deng; Chunlei Xia; Renhong Tang
Year: 2025
Venue: Cancer Research
Paper Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer
Lei, Josh Haipeng; Deng, Chu‐Xia · 2017 · International Journal of Biological Sciences · DOI
Full title: Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer
Authors: Lei, Josh Haipeng; Deng, Chu‐Xia
Year: 2017
Venue: International Journal of Biological Sciences
Paper Novel Biomarkers of Gastric Cancer: Current Research and Future Perspectives
Sato, Yasushi; Okamoto, Koichi; Kawano, Yutaka et al. · 2023 · Journal of Clinical Medicine · DOI
Full title: Novel Biomarkers of Gastric Cancer: Current Research and Future Perspectives
Authors: Sato, Yasushi; Okamoto, Koichi; Kawano, Yutaka; Kasai, Akinari; Kawaguchi, Tomoyuki; Sagawa, Tamotsu; Sogabe, Masahiro; Miyamoto, Hiroshi; Takayama, Tetsuji
Year: 2023
Venue: Journal of Clinical Medicine
Thesis Targeted delivery of alcohol-containing payloads with antibody-drug conjugates
Grier, Katja E.; id_orcid 0000-0002-9854-1440; Hansen, Anders H. et al. · 2023 · Technical University of Denmark (DTU) · DOI
Full title: Targeted delivery of alcohol-containing payloads with antibody-drug conjugates
Authors: Grier, Katja E.; id_orcid 0000-0002-9854-1440; Hansen, Anders H.; Haxvig, Christina S.; Li, Xin; Krigslund, Oliver; Behrendt, Niels; Engelholm, Lars H.; Rossi, Fabio; Sousa, Bebiana C.; Harradence, Grant J.; Camper, Nicolas; Qvortrup, Katrine M.; id_orcid 0000-0003-3828-2069
Year: 2023
Venue: Technical University of Denmark (DTU)
Thesis Use of a next generation maleimide in combination with THIOMAB (TM) antibody technology delivers a highly stable, potent and near homogeneous THIOMAB (TM) antibody-drug conjugate (TDC)
Nunes, JPM; Vassileva, V; Robinson, E et al. · 2017 · Imperial College London · DOI
Full title: Use of a next generation maleimide in combination with THIOMAB (TM) antibody technology delivers a highly stable, potent and near homogeneous THIOMAB (TM) antibody-drug conjugate (TDC)
Authors: Nunes, JPM; Vassileva, V; Robinson, E; Morais, M; Smith, MEB; Pedley, RB; Caddick, S; Baker, JR; Chudasama, V
Year: 2017
Venue: Imperial College London
Patent us-2010196364-a1
· 2010
Full title: us-2010196364-a1
Year: 2010
Patent us-2012134994-a1
· 2012
Full title: us-2012134994-a1
Year: 2012
Patent us-2014193899-a1
· 2014
Full title: us-2014193899-a1
Year: 2014
Patent us-2014301946-a1
· 2014
Full title: us-2014301946-a1
Year: 2014
Patent us-2014308201-a1
· 2014
Full title: us-2014308201-a1
Year: 2014
Patent us-2017106095-a1
· 2017
Full title: us-2017106095-a1
Year: 2017
Patent us-2016362496-a1
· 2016
Full title: us-2016362496-a1
Year: 2016
Patent us-2017008964-a1
· 2017
Full title: us-2017008964-a1
Year: 2017
Patent us-2018094063-a1
· 2018
Full title: us-2018094063-a1
Year: 2018
Patent us-2020085946-a1
· 2020
Full title: us-2020085946-a1
Year: 2020
Patent us-2019345250-a1
· 2019
Full title: us-2019345250-a1
Year: 2019
Patent us-9498532-b2
· 2016
Full title: us-9498532-b2
Year: 2016

2. Data Extraction

0
0/28 extracted
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Paper
First-in-Human Phase I Study of Aprutumab Ixadotin, a Fibroblast Growth Factor Receptor 2 Antibody-Drug Conjugate (BAY 1187982) in Patients with Advanced Cancer.
Kim, Sung-Bae; Meric-Bernstam, Funda; Kalyan, Aparna et al. · 2019
Full title: First-in-Human Phase I Study of Aprutumab Ixadotin, a Fibroblast Growth Factor Receptor 2 Antibody-Drug Conjugate (BAY 1187982) in Patients with Advanced Cancer.
Authors: Kim, Sung-Bae; Meric-Bernstam, Funda; Kalyan, Aparna; Babich, Aleksei; Liu, Rong; Tanigawa, Takahiko; Sommer, Anette; Osada, Motonobu; Reetz, Frank; Laurent, Dirk; Wittemer-Rump, Sabine; Berlin, Jordan
Paper
Generation of high-affinity, internalizing anti-FGFR2 single-chain variable antibody fragment fused with Fc for targeting gastrointestinal cancers.
Borek, Aleksandra; Sokolowska-Wedzina, Aleksandra; Chodaczek, Grzegorz et al. · 2018
Full title: Generation of high-affinity, internalizing anti-FGFR2 single-chain variable antibody fragment fused with Fc for targeting gastrointestinal cancers.
Authors: Borek, Aleksandra; Sokolowska-Wedzina, Aleksandra; Chodaczek, Grzegorz; Otlewski, Jacek
Thesis
Clinical Developments and Challenges in Treating FGFR2-Driven Gastric Cancer
Lau, DK; Collin, JP; Mariadason, JM · 2024
Full title: Clinical Developments and Challenges in Treating FGFR2-Driven Gastric Cancer
Authors: Lau, DK; Collin, JP; Mariadason, JM
Patent
us-10138301-b2
· 2018
Full title: us-10138301-b2
Patent
us-11406720-b2
· 2022
Full title: us-11406720-b2
Patent
us-11235059-b2
· 2022
Full title: us-11235059-b2
Patent
us-11866502-b2
· 2024
Full title: us-11866502-b2
Patent
us-2004014024-a1
· 2004
Full title: us-2004014024-a1
Patent
us-2010048620-a1
· 2010
Full title: us-2010048620-a1
Patent
us-2010047251-a1
· 2010
Full title: us-2010047251-a1
Patent
us-2012214829-a1
· 2012
Full title: us-2012214829-a1
Patent
us-2014140995-a1
· 2014
Full title: us-2014140995-a1
Patent
us-2015023989-a1
· 2015
Full title: us-2015023989-a1
Patent
us-2016096876-a1
· 2016
Full title: us-2016096876-a1
Patent
us-2016339100-a1
· 2016
Full title: us-2016339100-a1
Patent
us-2017349643-a1
· 2017
Full title: us-2017349643-a1
Patent
us-2021147812-a1
· 2021
Full title: us-2021147812-a1
Patent
us-2021293786-a1
· 2021
Full title: us-2021293786-a1
Patent
us-2022162323-a1
· 2022
Full title: us-2022162323-a1
Patent
us-2023055566-a1
· 2023
Full title: us-2023055566-a1
Patent
us-2024101683-a1
· 2024
Full title: us-2024101683-a1
Patent
us-2023242650-a1
· 2023
Full title: us-2023242650-a1
Patent
us-2024190973-a1
· 2024
Full title: us-2024190973-a1
Patent
us-2023052256-a1
· 2023
Full title: us-2023052256-a1
Patent
us-2025269016-a1
· 2025
Full title: us-2025269016-a1
Patent
us-2025243284-a1
· 2025
Full title: us-2025243284-a1
Patent
us-9506926-b2
· 2016
Full title: us-9506926-b2
Patent
us-8962655-b2
· 2015
Full title: us-8962655-b2

3. Authors & Profiles

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4. Email Outreach

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