PaperDetermination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra
Jarusintanakorn, Salinthip, Phechkrajang, Chutima, Khongkaew, Putthiporn, Mastrobattista, Enrico, Yamabhai, Montarop · 2021 · Analytical and Bioanalytical Chemistry · DOI
Full title: Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra
PaperBioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production
Tapia, Felipe, Vázquez-Ramírez, Daniel, Genzel, Yvonne, Reichl, Udo · 2016 · Applied Microbiology and Biotechnology · DOI
Full title: Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production
PaperEffects of autophagy-inhibiting chemicals on sialylation of Fc-fusion glycoprotein in recombinant CHO cells
Lee, Hoon-Min, Park, Jong‐Ho, Kim, Taeho, Kim, Hyun Seung, Kim, Dae Eung, Lee, Mi Kyeong, You, Jungmok, Lee, Gyun Min, Kim, Yeon‐Gu · 2024 · Applied Microbiology and Biotechnology · DOI
Full title: Effects of autophagy-inhibiting chemicals on sialylation of Fc-fusion glycoprotein in recombinant CHO cells
Authors: Lee, Hoon-Min, Park, Jong‐Ho, Kim, Taeho, Kim, Hyun Seung, Kim, Dae Eung, Lee, Mi Kyeong, You, Jungmok, Lee, Gyun Min, Kim, Yeon‐Gu
PaperInvestigation of the interactions of critical scale-up parameters (pH, pO2 and pCO2) on CHO batch performance and critical quality attributes
Brunner, Matthias, Fricke, Jens, Kröll, Paul, Herwig, Christoph · 2016 · Bioprocess and Biosystems Engineering · DOI
Full title: Investigation of the interactions of critical scale-up parameters (pH, pO2 and pCO2) on CHO batch performance and critical quality attributes
Authors: Brunner, Matthias, Fricke, Jens, Kröll, Paul, Herwig, Christoph
PaperMonitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors
Metze, Sabrina, Ruhl, S. F., Greller, Gerhard, Grimm, C., Scholz, Judith · 2019 · Bioprocess and Biosystems Engineering · DOI
Full title: Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors
PaperPre-stage perfusion and ultra-high seeding cell density in CHO fed-batch culture: a case study for process intensification guided by systems biotechnology
Full title: Pre-stage perfusion and ultra-high seeding cell density in CHO fed-batch culture: a case study for process intensification guided by systems biotechnology
PaperDynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation: applied to an industrial cell culture seed train
Rodríguez, Tanja Hernández, Posch, C., Pörtner, Ralf, Frahm, Björn · 2020 · Bioprocess and Biosystems Engineering · DOI
Full title: Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation: applied to an industrial cell culture seed train
Authors: Rodríguez, Tanja Hernández, Posch, C., Pörtner, Ralf, Frahm, Björn
PaperCompartment-specific metabolome labeling enables the identification of subcellular fluxes that may serve as promising metabolic engineering targets in CHO cells
Wijaya, Andy Wiranata, Ulmer, Andreas, Hundsdorfer, Lara, Verhagen, Natascha, Teleki, Attila, Takors, Ralf · 2021 · Bioprocess and Biosystems Engineering · DOI
Full title: Compartment-specific metabolome labeling enables the identification of subcellular fluxes that may serve as promising metabolic engineering targets in CHO cells
PaperEnhancement of recombinant human IL-24 (rhIL-24) protein production from site-specific integrated engineered CHO cells by sodium butyrate treatment
Full title: Enhancement of recombinant human IL-24 (rhIL-24) protein production from site-specific integrated engineered CHO cells by sodium butyrate treatment
PaperImpact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins
Wolnick, Nicolas, Dickson, Marissa, Webster, Thaddaeus A., Connolly, Roger P., Fernandes, Nancy, Encheva, Vesela, Crittenden, Hunter, Hodgkins, Jessica, Hadley, Brian C., Palermo, Gabriella, Hendrick, Shannon, Newell, Roy A., Gray, Genevieve, Siltanen, Christian, Armstrong, Julia, Downey, Brandon, Mason, Carrie · 2024 · Bioprocess and Biosystems Engineering · DOI
Full title: Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins
Authors: Wolnick, Nicolas, Dickson, Marissa, Webster, Thaddaeus A., Connolly, Roger P., Fernandes, Nancy, Encheva, Vesela, Crittenden, Hunter, Hodgkins, Jessica, Hadley, Brian C., Palermo, Gabriella, Hendrick, Shannon, Newell, Roy A., Gray, Genevieve, Siltanen, Christian, Armstrong, Julia, Downey, Brandon, Mason, Carrie
PaperUsing simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
López-Meza, Julián, Araíz-Hernández, Diana, Carrillo‐Cocom, Leydi Maribel, López‐Pacheco, Felipe, Rocha-Pizaña, María del Refugio, Álvarez, Mario Moisés · 2015 · Cytotechnology · DOI
Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
Authors: López-Meza, Julián, Araíz-Hernández, Diana, Carrillo‐Cocom, Leydi Maribel, López‐Pacheco, Felipe, Rocha-Pizaña, María del Refugio, Álvarez, Mario Moisés
PaperPID controls: the forgotten bioprocess parameters
Harcum, Sarah W., Elliott, Kathryn, Skelton, Bradley A., Klaubert, Stephanie R., Dahodwala, Hussain, Lee, Kelvin H. · 2022 · Discover Chemical Engineering · DOI
Full title: PID controls: the forgotten bioprocess parameters
Authors: Harcum, Sarah W., Elliott, Kathryn, Skelton, Bradley A., Klaubert, Stephanie R., Dahodwala, Hussain, Lee, Kelvin H.
PaperMucin 21 confers resistance to apoptosis in an O-glycosylation-dependent manner
Yuan Tian, K. Denda-Nagai, T. Tsukui, K. Ishii-Schrade, K. Okada, Y. Nishizono, Kosuke Matsuzaki, Margarete Hafley, R. Bresalier, T. Irimura · 2022 · Cell Death Discovery · DOI
Full title: Mucin 21 confers resistance to apoptosis in an O-glycosylation-dependent manner
Authors: Yuan Tian, K. Denda-Nagai, T. Tsukui, K. Ishii-Schrade, K. Okada, Y. Nishizono, Kosuke Matsuzaki, Margarete Hafley, R. Bresalier, T. Irimura
PaperThe glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells
Weihua Tian, Zilu Ye, Shengjun Wang, M. A. Schulz, Julie Van Coillie, Lingbo Sun, Yen-Hsi Chen, Yoshiki Narimatsu, L. Hansen, C. Kristensen, U. Mandel, E. Bennett, S. Jabbarzadeh-Tabrizi, R. Schiffmann, Jinsong Shen, S. Vakhrushev, H. Clausen, Zhang Yang · 2019 · Nature Communications · DOI
Full title: The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells
Authors: Weihua Tian, Zilu Ye, Shengjun Wang, M. A. Schulz, Julie Van Coillie, Lingbo Sun, Yen-Hsi Chen, Yoshiki Narimatsu, L. Hansen, C. Kristensen, U. Mandel, E. Bennett, S. Jabbarzadeh-Tabrizi, R. Schiffmann, Jinsong Shen, S. Vakhrushev, H. Clausen, Zhang Yang
PaperGenome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
Gutierrez, Jahir M., Feizi, Amir, Li, Shangzhong, Kallehauge, Thomas Beuchert, Hefzi, Hooman, Grav, Lise Marie, Ley, Daniel, Hızal, Deniz Baycın, Betenbaugh, Michael J., Voldborg, Björn G., Kildegaard, Helene Faustrup, Lee, Gyun Min, Palsson, Bernhard Ø., Nielsen, Jens, Lewis, Nathan E. · 2020 · Nature Communications · DOI
Full title: Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
Authors: Gutierrez, Jahir M., Feizi, Amir, Li, Shangzhong, Kallehauge, Thomas Beuchert, Hefzi, Hooman, Grav, Lise Marie, Ley, Daniel, Hızal, Deniz Baycın, Betenbaugh, Michael J., Voldborg, Björn G., Kildegaard, Helene Faustrup, Lee, Gyun Min, Palsson, Bernhard Ø., Nielsen, Jens, Lewis, Nathan E.
PaperPerfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation and ER stress in CHO cells
Sinharoy, Pritam, Aziz, Aaron H., Majewska, Natalia I., Ahuja, Sanjeev, Handlogten, Michael W. · 2020 · Scientific Reports · DOI
Full title: Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation and ER stress in CHO cells
Authors: Sinharoy, Pritam, Aziz, Aaron H., Majewska, Natalia I., Ahuja, Sanjeev, Handlogten, Michael W.
Cai, Cindy X., Doria‐Rose, Nicole A., Schneck, Nicole A., Ivleva, Vera B., Tippett, Brad, Shadrick, William R., O’Connell, Sarah, Cooper, Jonathan W., Schneiderman, Zachary, Zhang, Baoshan, Gowetski, Daniel B., Blackstock, Daniel, Demirji, Jacob, Lin, Bob C., Gorman, Jason, Liu, Tracy, Li, Yile, McDermott, Adrian B., Kwong, Peter D., Carlton, Kevin, Gall, Jason G., Lei, Q. Paula · 2022 · Scientific Reports · DOI
Full title: Tyrosine O-sulfation proteoforms affect HIV-1 monoclonal antibody potency
Authors: Cai, Cindy X., Doria‐Rose, Nicole A., Schneck, Nicole A., Ivleva, Vera B., Tippett, Brad, Shadrick, William R., O’Connell, Sarah, Cooper, Jonathan W., Schneiderman, Zachary, Zhang, Baoshan, Gowetski, Daniel B., Blackstock, Daniel, Demirji, Jacob, Lin, Bob C., Gorman, Jason, Liu, Tracy, Li, Yile, McDermott, Adrian B., Kwong, Peter D., Carlton, Kevin, Gall, Jason G., Lei, Q. Paula
PaperMicroevolutionary dynamics of eccDNA in Chinese hamster ovary cells grown in fed-batch cultures under control and lactate-stressed conditions
Chitwood, Dylan G., Wang, Qinghua, Klaubert, Stephanie R., Green, Kiana, Wu, Cathy, Harcum, Sarah W., Saski, Christopher · 2023 · Scientific Reports · DOI
Full title: Microevolutionary dynamics of eccDNA in Chinese hamster ovary cells grown in fed-batch cultures under control and lactate-stressed conditions
Authors: Chitwood, Dylan G., Wang, Qinghua, Klaubert, Stephanie R., Green, Kiana, Wu, Cathy, Harcum, Sarah W., Saski, Christopher
PaperMachine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing
Williams, Thomas J., Kalinka, Kevin, Sanches, Rui, Blanchard-Emmerson, Greg, Watts, Samuel, Davies, Lee, Knevelman, Carol, McCloskey, Laura J., Jones, Peter B., Mitrophanous, Kyriacos, Miskin, James, Dikicioǧlu, Duygu · 2023 · Scientific Reports · DOI
Full title: Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing
Authors: Williams, Thomas J., Kalinka, Kevin, Sanches, Rui, Blanchard-Emmerson, Greg, Watts, Samuel, Davies, Lee, Knevelman, Carol, McCloskey, Laura J., Jones, Peter B., Mitrophanous, Kyriacos, Miskin, James, Dikicioǧlu, Duygu
PaperModifying the glycosylation profile of SARS-CoV-2 spike-based subunit vaccines alters focusing of the humoral immune response in a mouse model
Tyler M Renner, M. Stuible, M. Rossotti, Nazanin Rohani, Yuneivy Cepero-Donates, Janelle Sauvageau, L. Deschatelets, R. Dudani, Blair A. Harrison, Jason Baardsnes, Izel Koyuturk, F. St. Michael, Jennifer J Hill, U. Hemraz, A. Lenferink, J. Tanha, Bárbara Fernandes, António Roldão, M. McCluskie, Bassel Akache, Yves Durocher · 2025 · Communications Medicine · DOI
Full title: Modifying the glycosylation profile of SARS-CoV-2 spike-based subunit vaccines alters focusing of the humoral immune response in a mouse model
Authors: Tyler M Renner, M. Stuible, M. Rossotti, Nazanin Rohani, Yuneivy Cepero-Donates, Janelle Sauvageau, L. Deschatelets, R. Dudani, Blair A. Harrison, Jason Baardsnes, Izel Koyuturk, F. St. Michael, Jennifer J Hill, U. Hemraz, A. Lenferink, J. Tanha, Bárbara Fernandes, António Roldão, M. McCluskie, Bassel Akache, Yves Durocher
PaperRibosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion
Kallehauge, Thomas Beuchert, Li, Shangzhong, Pedersen, Lasse Ebdrup, Ha, Tae Kwang, Ley, Daniel, Andersen, Mikael Rørdam, Kildegaard, Helene Faustrup, Lee, Gyun Min, Lewis, Nathan E. · 2017 · Scientific Reports · DOI
Full title: Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion
Authors: Kallehauge, Thomas Beuchert, Li, Shangzhong, Pedersen, Lasse Ebdrup, Ha, Tae Kwang, Ley, Daniel, Andersen, Mikael Rørdam, Kildegaard, Helene Faustrup, Lee, Gyun Min, Lewis, Nathan E.
Paper<i>N</i>-Glycosylation profiling of intact target proteins by high-resolution mass spectrometry (MS) and glycan analysis using ion mobility-MS/MS
Quaranta, Alessandro, Spasova, Maya, Passarini, Elena, Karlsson, Isabella, Ndreu, Lorena, Thorsén, Gunnar, Ilag, Leopold L. · 2019 · The Analyst · DOI
Full title: <i>N</i>-Glycosylation profiling of intact target proteins by high-resolution mass spectrometry (MS) and glycan analysis using ion mobility-MS/MS
Authors: Quaranta, Alessandro, Spasova, Maya, Passarini, Elena, Karlsson, Isabella, Ndreu, Lorena, Thorsén, Gunnar, Ilag, Leopold L.
PaperGlycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster ovary fed-batch cultures
Hutter, Sandro, Villiger, Thomas K., Brühlmann, David, Stettler, Matthieu, Broly, Hervé, Šoóš, Miroslav, Gunawan, Rudiyanto · 2017 · DOI
Full title: Glycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster ovary fed-batch cultures
Authors: Hutter, Sandro, Villiger, Thomas K., Brühlmann, David, Stettler, Matthieu, Broly, Hervé, Šoóš, Miroslav, Gunawan, Rudiyanto
PaperA recombinant gp145 Env glycoprotein from HIV-1 expressed in two different cell lines: effects on glycosylation and antigenicity
González‐Feliciano, José A., Akamine, Pearl, Capó-Vélez, Coral M., Delgado‐Vélez, Manuel, Dussupt, Vincent, Krebs, Shelly J., Wojna, Valerie, Polonis, Victoria R., Baerga‐Ortiz, Abel, Lasalde‐Dominicci, José A. · 2020 · DOI
Full title: A recombinant gp145 Env glycoprotein from HIV-1 expressed in two different cell lines: effects on glycosylation and antigenicity
Authors: González‐Feliciano, José A., Akamine, Pearl, Capó-Vélez, Coral M., Delgado‐Vélez, Manuel, Dussupt, Vincent, Krebs, Shelly J., Wojna, Valerie, Polonis, Victoria R., Baerga‐Ortiz, Abel, Lasalde‐Dominicci, José A.
PaperProduction of Trimeric SARS-CoV-2 Spike Protein by CHO Cells for Serological COVID-19 Testing
Johari, Yusuf B., Jaffe, Stephen, Scarrott, Joseph M., Johnson, Abayomi O., Mozzanino, Théo, Pohle, Thilo H., Maisuria, Sheetal, Bhayat‐Cammack, Amina, Brown, Adam, Tee, Kang Lan, Jackson, Philip J., Wong, Tuck Seng, Dickman, Mark J., Sargur, Ravishankar, James, David C. · 2020 · DOI
Full title: Production of Trimeric SARS-CoV-2 Spike Protein by CHO Cells for Serological COVID-19 Testing
Authors: Johari, Yusuf B., Jaffe, Stephen, Scarrott, Joseph M., Johnson, Abayomi O., Mozzanino, Théo, Pohle, Thilo H., Maisuria, Sheetal, Bhayat‐Cammack, Amina, Brown, Adam, Tee, Kang Lan, Jackson, Philip J., Wong, Tuck Seng, Dickman, Mark J., Sargur, Ravishankar, James, David C.
PaperIdentification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening
Kim, Su Hyun, Shin, Seunghyeon, Baek, Minhye, Xiong, Kai, Karottki, Karen Julie la Cour, Hefzi, Hooman, Grav, Lise Marie, Pedersen, Lasse Ebdrup, Kildegaard, Helene Faustrup, Lewis, Nathan E., Lee, Jae Seong, Lee, Gyun Min · 2022 · DOI
Full title: Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening
Authors: Kim, Su Hyun, Shin, Seunghyeon, Baek, Minhye, Xiong, Kai, Karottki, Karen Julie la Cour, Hefzi, Hooman, Grav, Lise Marie, Pedersen, Lasse Ebdrup, Kildegaard, Helene Faustrup, Lewis, Nathan E., Lee, Jae Seong, Lee, Gyun Min
PaperTemporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch and Perfusion Bioreactor Operation
Gyorgypal, Aron, Fratz‐Berilla, Erica J., Kohnhorst, Casey, Powers, David N., Chundawat, Shishir P. S. · 2023 · DOI
Full title: Temporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch and Perfusion Bioreactor Operation
Authors: Gyorgypal, Aron, Fratz‐Berilla, Erica J., Kohnhorst, Casey, Powers, David N., Chundawat, Shishir P. S.
PaperChoice of host cell line is essential for the functional glycosylation of the fragment crystallizable (Fc) region of human IgG1 inhibitors of influenza B viruses
P. Blundell, Dongli Lu, A. Dell, S. Haslam, R. Pleass · 2019 · bioRxiv · DOI
Full title: Choice of host cell line is essential for the functional glycosylation of the fragment crystallizable (Fc) region of human IgG1 inhibitors of influenza B viruses
Authors: P. Blundell, Dongli Lu, A. Dell, S. Haslam, R. Pleass
PaperVisualization of the HIV-1 Env Glycan Shield Across Scales
Berndsen, Zachary T., Chakraborty, Srirupa, Wang, Xiaoning, Cottrell, Christopher A., Torres, Jonathan L., Diedrich, Jolene K., López, César A., Yates, John R., Gils, Marit J. van, Paulson, James C., Gnanakaran, S., Ward, Andrew B. · 2019 · DOI
Full title: Visualization of the HIV-1 Env Glycan Shield Across Scales
Authors: Berndsen, Zachary T., Chakraborty, Srirupa, Wang, Xiaoning, Cottrell, Christopher A., Torres, Jonathan L., Diedrich, Jolene K., López, César A., Yates, John R., Gils, Marit J. van, Paulson, James C., Gnanakaran, S., Ward, Andrew B.
PaperInfluência do butirato de sódio, da cicloheximida e do cloreto de manganês na produtividade, glicosilação e propriedades biológicas da tireotrofina humana derivada de CHO
Full title: Influência do butirato de sódio, da cicloheximida e do cloreto de manganês na produtividade, glicosilação e propriedades biológicas da tireotrofina humana derivada de CHO
PaperSynergizing metabolic flux analysis and nucleotide sugar metabolism to understand the control of glycosylation of recombinant protein in CHO cells
Burleigh, Susan C, Laar, Teun van de, Stroop, Corné J.M., Grunsven, Wout MJ van, O’Donoghue, Niaobh, Rudd, Pauline M., Davey, Gavin P. · 2011 · BMC Biotechnology · DOI
Full title: Synergizing metabolic flux analysis and nucleotide sugar metabolism to understand the control of glycosylation of recombinant protein in CHO cells
Authors: Burleigh, Susan C, Laar, Teun van de, Stroop, Corné J.M., Grunsven, Wout MJ van, O’Donoghue, Niaobh, Rudd, Pauline M., Davey, Gavin P.
PaperIdentification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells
Sumitomo, Yasuhiko, Higashitsuji, Hiroaki, Higashitsuji, Hisako, Liu, Yu, Fujita, Takanori, Sakurai, Toshiharu, Candeias, Marco M., Itoh, Katsuhiko, Chiba, Tsutomu, Fujita, Jun · 2012 · BMC Biotechnology · DOI
Full title: Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells
Authors: Sumitomo, Yasuhiko, Higashitsuji, Hiroaki, Higashitsuji, Hisako, Liu, Yu, Fujita, Takanori, Sakurai, Toshiharu, Candeias, Marco M., Itoh, Katsuhiko, Chiba, Tsutomu, Fujita, Jun
PaperDouble knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC
Full title: Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC
PaperCell functional enviromics: Unravelling the function of environmental factors
Teixeira, Ana P., Dias, João M.L., Carinhas, Nuno, Sousa, Marcos F. Q., Clemente, João J., Cunha, António E., Stosch, Moritz von, Alves, Paula M., Carrondo, Manuel J.T., Oliveira, Rui · 2011 · BMC Systems Biology · DOI
Full title: Cell functional enviromics: Unravelling the function of environmental factors
Authors: Teixeira, Ana P., Dias, João M.L., Carinhas, Nuno, Sousa, Marcos F. Q., Clemente, João J., Cunha, António E., Stosch, Moritz von, Alves, Paula M., Carrondo, Manuel J.T., Oliveira, Rui
PaperNon-stationary 13C metabolic flux analysis of Chinese hamster ovary cells in batch culture using extracellular labeling highlights metabolic reversibility and compartmentation
Nicolae, Averina, Wahrheit, Judith, Bahnemann, Janina, Zeng, An‐Ping, Heinzle, Elmar · 2014 · BMC Systems Biology · DOI
Full title: Non-stationary 13C metabolic flux analysis of Chinese hamster ovary cells in batch culture using extracellular labeling highlights metabolic reversibility and compartmentation
PaperSingle use bioreactors for the clinical production of monoclonal antibodies – a study to analyze the performance of a CHO cell line and the quality of the produced monoclonal antibody
Sonja Diekmann, Constanze Dürr, Alexander Herrmann, Ingo Lindner, Daniela Jozic · 2011 · BMC Proceedings · DOI
Full title: Single use bioreactors for the clinical production of monoclonal antibodies – a study to analyze the performance of a CHO cell line and the quality of the produced monoclonal antibody
PaperCharacterization of metalloprotease and serine protease activities in batch CHO cell cultures: control of human recombinant IFN-γ proteolysis by addition of iron citrate
Full title: Characterization of metalloprotease and serine protease activities in batch CHO cell cultures: control of human recombinant IFN-γ proteolysis by addition of iron citrate
PaperAnalysis of glycolytic flux as a rapid screen to identify low lactate producing CHO cell lines with desirable monoclonal antibody yield and glycan profile
R. Legmann, Julie Melito, I. Belzer, D. Ferrick · 2011 · BMC Proceedings · DOI
Full title: Analysis of glycolytic flux as a rapid screen to identify low lactate producing CHO cell lines with desirable monoclonal antibody yield and glycan profile
Authors: R. Legmann, Julie Melito, I. Belzer, D. Ferrick
PaperProtein folding and glycosylation process are influenced by mild hypothermia in batch culture and by specific growth rate in continuous cultures of CHO cells producing rht-PA
M. Vergara, S. Becerra, J. Berrios, J. Reyes, C. Acevedo, R. Gonzalez, N. Osses, C. Altamirano · 2013 · BMC Proceedings · DOI
Full title: Protein folding and glycosylation process are influenced by mild hypothermia in batch culture and by specific growth rate in continuous cultures of CHO cells producing rht-PA
Authors: M. Vergara, S. Becerra, J. Berrios, J. Reyes, C. Acevedo, R. Gonzalez, N. Osses, C. Altamirano
PaperCHO starter cell lines for manufacturing of proteins with pre-defined glycoprofiles
K. Winkler, M. Thiele, R. Berthold, Nicole Kirschenbaum, Marco Sczepanski, H. V. Horsten, S. Seitz, N. Arnold, A. Scheidig, V. Sandig · 2013 · BMC Proceedings · DOI
Full title: CHO starter cell lines for manufacturing of proteins with pre-defined glycoprofiles
Authors: K. Winkler, M. Thiele, R. Berthold, Nicole Kirschenbaum, Marco Sczepanski, H. V. Horsten, S. Seitz, N. Arnold, A. Scheidig, V. Sandig
PaperUnderstanding the impact of different bioprocess conditions on monoclonal antibody glycosylation in CHO cell cultures through experimental and computational analyses
Sou, Si Nga, Sellick, Christopher, Lee, Ken, Mason, Alison, Kyriakopoulos, Sarantos, Polizzi, Karen M., Kontoravdi, Cleo · 2015 · BMC Proceedings · DOI
Full title: Understanding the impact of different bioprocess conditions on monoclonal antibody glycosylation in CHO cell cultures through experimental and computational analyses
Authors: Sou, Si Nga, Sellick, Christopher, Lee, Ken, Mason, Alison, Kyriakopoulos, Sarantos, Polizzi, Karen M., Kontoravdi, Cleo
Paperambr™ Mini-bioreactor as a high-throughput tool for culture process development to accelerate transfer to stainless steel manufacturing scale: comparability study from process performance to product quality attributes
Frédéric Delouvroy, Gaetan Siriez, A. Tran, Larissa Mukankurayija, N. Kochanowski, Laetitia Malphettes · 2015 · BMC Proceedings · DOI
Full title: ambr™ Mini-bioreactor as a high-throughput tool for culture process development to accelerate transfer to stainless steel manufacturing scale: comparability study from process performance to product quality attributes
Authors: Frédéric Delouvroy, Gaetan Siriez, A. Tran, Larissa Mukankurayija, N. Kochanowski, Laetitia Malphettes
PaperGenerating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper(II)
York, Dona, Baker, Jeanne, Holder, Patrick G., Jones, Lesley, Drake, Penelope M., Barfield, Robyn M., Bleck, Gregory T., Rabuka, David · 2016 · BMC Biotechnology · DOI
Full title: Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper(II)
Authors: York, Dona, Baker, Jeanne, Holder, Patrick G., Jones, Lesley, Drake, Penelope M., Barfield, Robyn M., Bleck, Gregory T., Rabuka, David
PaperCharacterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cells grown in fed-batch cultures
Chitwood, Dylan G., Wang, Qinghua, Elliott, Kathryn, Bullock, Aiyana, Jordana, Dwon, Li, Zhigang, Wu, Cathy, Harcum, Sarah W., Saski, Christopher · 2021 · BMC Biotechnology · DOI
Full title: Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cells grown in fed-batch cultures
Authors: Chitwood, Dylan G., Wang, Qinghua, Elliott, Kathryn, Bullock, Aiyana, Jordana, Dwon, Li, Zhigang, Wu, Cathy, Harcum, Sarah W., Saski, Christopher
PaperRoles of N-linked and O-linked glycosylation sites in the activity of equine chorionic gonadotropin in cells expressing rat luteinizing hormone/chorionic gonadotropin receptor and follicle-stimulating hormone receptor
Full title: Roles of N-linked and O-linked glycosylation sites in the activity of equine chorionic gonadotropin in cells expressing rat luteinizing hormone/chorionic gonadotropin receptor and follicle-stimulating hormone receptor
PaperAbstracts from the 26th European Society for Animal Cell Technology Meeting - Cell culture technologies: bridging academia and industry to provide solutions for patients
Full title: Abstracts from the 26th European Society for Animal Cell Technology Meeting - Cell culture technologies: bridging academia and industry to provide solutions for patients
PaperSWATH-MS insights on sodium butyrate effect on mAbs production and redox homeostasis in CHO cells
Mauro Galli, Lillian Chia-Yi Liu, Kae Hwan Sim, Y. Kok, Katherine Wongtrakul-Kish, Terry Nguyen-Khuong, Stephen Tate, Xuezhi Bi · 2024 · AMB Express · DOI
Full title: SWATH-MS insights on sodium butyrate effect on mAbs production and redox homeostasis in CHO cells
Authors: Mauro Galli, Lillian Chia-Yi Liu, Kae Hwan Sim, Y. Kok, Katherine Wongtrakul-Kish, Terry Nguyen-Khuong, Stephen Tate, Xuezhi Bi
PaperResponses of CHO-DHFR cells to ratio of asparagine to glutamine in feed media: cell growth, antibody production, metabolic waste, glutamate, and energy metabolism
Full title: Responses of CHO-DHFR cells to ratio of asparagine to glutamine in feed media: cell growth, antibody production, metabolic waste, glutamate, and energy metabolism
PaperCell-culture growth conditions resulting in the oxidation of a recombinant antigen-binding fragment
Siddiquee, Khandaker, Zhao, Cheng, Stemler, Michelle, Zeck, Bill, Fishpaugh, Jeffrey R., Allen, Steven P. · 2019 · Bioresources and Bioprocessing · DOI
Full title: Cell-culture growth conditions resulting in the oxidation of a recombinant antigen-binding fragment
Authors: Siddiquee, Khandaker, Zhao, Cheng, Stemler, Michelle, Zeck, Bill, Fishpaugh, Jeffrey R., Allen, Steven P.
PaperBigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process
Morris, Caitlin, Polanco, Ashli, Yongky, Andrew, Xu, Jianlin, Huang, Zhuangrong, Zhao, Jia, McFarland, Kevin S., Park, Seo‐Young, Warrack, Bethanne M., Reily, Michael D., Borys, Michael, Li, Zheng Jian, Yoon, Seongkyu · 2020 · Bioresources and Bioprocessing · DOI
Full title: Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process
Authors: Morris, Caitlin, Polanco, Ashli, Yongky, Andrew, Xu, Jianlin, Huang, Zhuangrong, Zhao, Jia, McFarland, Kevin S., Park, Seo‐Young, Warrack, Bethanne M., Reily, Michael D., Borys, Michael, Li, Zheng Jian, Yoon, Seongkyu
PaperSeed train process intensification strategy offers potential for rapid, cost-effective scale-up of biosimilars manufacturing
Rajib Malla, D. Shah, Chinmay N Gajendragadkar, Vijayalakshmi Vamanan, Deepak Singh, Suraj Gupta, Deepak Vengovan, Ravi Trivedi, H. Weichert, Melisa Carpio, K. Chandran · 2021 · BioProcessing Journal · DOI
Full title: Seed train process intensification strategy offers potential for rapid, cost-effective scale-up of biosimilars manufacturing
Authors: Rajib Malla, D. Shah, Chinmay N Gajendragadkar, Vijayalakshmi Vamanan, Deepak Singh, Suraj Gupta, Deepak Vengovan, Ravi Trivedi, H. Weichert, Melisa Carpio, K. Chandran
PaperSpecific Biological Activity of Equine Chorionic Gonadotropin (eCG) Glycosylation Sites in Cells Expressing Equine Luteinizing Hormone/CG (eLH/CG) Receptor
Byambaragchaa, Munkhzaya, Choi, Seung-Hee, Joo, Hyo-Eun, Kim, Sang-Gwon, Kim, Yean-Ji, Park, Gyeong-Eun, Kang, Myung-Hwa, Min, Kwan-Sik · 2021 · Development & Reproduction · DOI
Full title: Specific Biological Activity of Equine Chorionic Gonadotropin (eCG) Glycosylation Sites in Cells Expressing Equine Luteinizing Hormone/CG (eLH/CG) Receptor
Authors: Byambaragchaa, Munkhzaya, Choi, Seung-Hee, Joo, Hyo-Eun, Kim, Sang-Gwon, Kim, Yean-Ji, Park, Gyeong-Eun, Kang, Myung-Hwa, Min, Kwan-Sik
PaperEndoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat Cultures
Vergara, Mauricio, Berríos, Julio, Martínez, Irene, Díaz‐Barrera, Alvaro, Acevedo, Cristián, Reyes, Juan G., González, Ramón, Altamirano, Claudia · 2015 · PLoS ONE · DOI
Full title: Endoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat Cultures
PaperEffect of Temperature Downshift on the Transcriptomic Responses of Chinese Hamster Ovary Cells Using Recombinant Human Tissue Plasminogen Activator Production Culture
Bedoya-López, Andrea, Estrada, Karel, Sánchez‐Flores, Alejandro, Ramı́rez, Octavio T., Altamirano, Claudia, Segovia, Lorenzo, Miranda‐Ríos, Juan, Trujillo‐Roldán, Mauricio A., Valdez‐Cruz, Norma A. · 2016 · PLoS ONE · DOI
Full title: Effect of Temperature Downshift on the Transcriptomic Responses of Chinese Hamster Ovary Cells Using Recombinant Human Tissue Plasminogen Activator Production Culture
PaperUnderstanding and Controlling Sialylation in a CHO Fc-Fusion Process
Lewis, Amanda M., Croughan, William D., Aranı́bar, Nelly, Lee, Alison G., Warrack, Bethanne M., Abu‐Absi, Nicholas R., Patel, Rutva, Drew, Barry, Borys, Michael, Reily, Michael D., Li, Zheng Jian · 2016 · PLoS ONE · DOI
Full title: Understanding and Controlling Sialylation in a CHO Fc-Fusion Process
Authors: Lewis, Amanda M., Croughan, William D., Aranı́bar, Nelly, Lee, Alison G., Warrack, Bethanne M., Abu‐Absi, Nicholas R., Patel, Rutva, Drew, Barry, Borys, Michael, Reily, Michael D., Li, Zheng Jian
PaperRobotic selection for the rapid development of stable CHO cell lines for HIV vaccine production
O’Rourke, Sara M., Byrne, Gabriel, Tatsuno, Gwen P., Wright, Meredith, Yu, Bin, Mesa, Kathryn A., Doran, Rachel C., Alexander, David L., Berman, Phillip W. · 2018 · PLoS ONE · DOI
Full title: Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production
Authors: O’Rourke, Sara M., Byrne, Gabriel, Tatsuno, Gwen P., Wright, Meredith, Yu, Bin, Mesa, Kathryn A., Doran, Rachel C., Alexander, David L., Berman, Phillip W.
PaperHigh glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells
Vergara, Mauricio, Torres, Mauro, Müller, Andrea, Avello, Verónica, Acevedo, Cristián, Berríos, Julio, Reyes, Juan G., Valdez‐Cruz, Norma A., Altamirano, Claudia · 2018 · PLoS ONE · DOI
Full title: High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells
PaperA recombinant gp145 Env glycoprotein from HIV-1 expressed in two different cell lines: Effects on glycosylation and antigenicity
González‐Feliciano, José A., Akamine, Pearl, Capó-Vélez, Coral M., Delgado‐Vélez, Manuel, Dussupt, Vincent, Krebs, Shelly J., Wojna, Valerie, Polonis, Victoria R., Baerga‐Ortiz, Abel, Lasalde‐Dominicci, José A. · 2020 · PLoS ONE · DOI
Full title: A recombinant gp145 Env glycoprotein from HIV-1 expressed in two different cell lines: Effects on glycosylation and antigenicity
Authors: González‐Feliciano, José A., Akamine, Pearl, Capó-Vélez, Coral M., Delgado‐Vélez, Manuel, Dussupt, Vincent, Krebs, Shelly J., Wojna, Valerie, Polonis, Victoria R., Baerga‐Ortiz, Abel, Lasalde‐Dominicci, José A.
PaperGene editing in CHO cells to prevent proteolysis and enhance glycosylation: Production of HIV envelope proteins as vaccine immunogens
Li, Sophia W., Wright, Meredith, Healey, John F., Hutchinson, Jennie M., O’Rourke, Sara M., Mesa, Kathryn A., Lollar, Pete, Berman, Phillip W. · 2020 · PLoS ONE · DOI
Full title: Gene editing in CHO cells to prevent proteolysis and enhance glycosylation: Production of HIV envelope proteins as vaccine immunogens
Authors: Li, Sophia W., Wright, Meredith, Healey, John F., Hutchinson, Jennie M., O’Rourke, Sara M., Mesa, Kathryn A., Lollar, Pete, Berman, Phillip W.
PaperEvidence for co-translational misincorporation of non-canonical amino acid hydroxyproline in recombinant antibodies produced in Chinese Hamster Ovary (CHO) cell lines
Boddapati, Shanta, Gilmore, Jason M., Boone, Kyle, Bushey, John, Ross, Jonathan, Gfeller, Brian, McFee, William A., Rao, Romesh, Corrigan, Greg, Chen, Aaron, Clarke, Howard R. G., Valliere‐Douglass, John, Bhargava, Swapnil · 2020 · PLoS ONE · DOI
Full title: Evidence for co-translational misincorporation of non-canonical amino acid hydroxyproline in recombinant antibodies produced in Chinese Hamster Ovary (CHO) cell lines
Authors: Boddapati, Shanta, Gilmore, Jason M., Boone, Kyle, Bushey, John, Ross, Jonathan, Gfeller, Brian, McFee, William A., Rao, Romesh, Corrigan, Greg, Chen, Aaron, Clarke, Howard R. G., Valliere‐Douglass, John, Bhargava, Swapnil
PaperOptimization of transient protein production by chemically transfected CHO suspension cells
Elshereef, Abdalla Adel Sabry Abdelrazik Mohamed · 2018 · Institutional Repository of Leibniz Universität Hannover (Leibniz Universität Hannover) · DOI
Full title: Optimization of transient protein production by chemically transfected CHO suspension cells
PaperDeciphering Metabolic Pathways in High Seeding Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective
Full title: Deciphering Metabolic Pathways in High Seeding Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective
PaperOuantitative Proteomic Analysis of Cellular Responses to a Designed Amino Acid Feed in a Monoclonal Antibody Producing Chinese Hamster Ovary Cell Line
Full title: Ouantitative Proteomic Analysis of Cellular Responses to a Designed Amino Acid Feed in a Monoclonal Antibody Producing Chinese Hamster Ovary Cell Line
PaperProteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Productivity and Product Quality.
Strasser, Lisa, Farrell, Amy, Ho, Jenny T C, Scheffler, Kai, Cook, Ken, Pankert, Patrick, Mowlds, Peter, Viner, Rosa, Karger, Barry L, Bones, Jonathan · 2021 · Frontiers in bioengineering and biotechnology · DOI
Full title: Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Productivity and Product Quality.
Authors: Strasser, Lisa, Farrell, Amy, Ho, Jenny T C, Scheffler, Kai, Cook, Ken, Pankert, Patrick, Mowlds, Peter, Viner, Rosa, Karger, Barry L, Bones, Jonathan
Year: 2021
Venue: Frontiers in bioengineering and biotechnology
PaperModel Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments
Bayer, Benjamin, Duerkop, Mark, Striedner, Gerald, Sissolak, Bernhard · 2021 · Frontiers in Bioengineering and Biotechnology · DOI
Full title: Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments
Authors: Bayer, Benjamin, Duerkop, Mark, Striedner, Gerald, Sissolak, Bernhard
Year: 2021
Venue: Frontiers in Bioengineering and Biotechnology
PaperBoosting Productivity for Advanced Biomanufacturing by Re-Using Viable Cells
Reger, Lucas Nik, Saballus, Martin, Matuszczyk, Jens, Kampmann, Markus, Wijffels, René H., Martens, Dirk E., Niemann, Julia · 2023 · Frontiers in Bioengineering and Biotechnology · DOI
Full title: Boosting Productivity for Advanced Biomanufacturing by Re-Using Viable Cells
Authors: Reger, Lucas Nik, Saballus, Martin, Matuszczyk, Jens, Kampmann, Markus, Wijffels, René H., Martens, Dirk E., Niemann, Julia
Year: 2023
Venue: Frontiers in Bioengineering and Biotechnology
PaperA novel hybrid bioprocess strategy addressing key challenges of advanced biomanufacturing
Reger, Lucas Nik, Saballus, Martin, Kappes, Annika, Kampmann, Markus, Wijffels, René H., Martens, Dirk E., Niemann, Julia · 2023 · Frontiers in Bioengineering and Biotechnology · DOI
Full title: A novel hybrid bioprocess strategy addressing key challenges of advanced biomanufacturing
Authors: Reger, Lucas Nik, Saballus, Martin, Kappes, Annika, Kampmann, Markus, Wijffels, René H., Martens, Dirk E., Niemann, Julia
Year: 2023
Venue: Frontiers in Bioengineering and Biotechnology
PaperBoost dynamic protocols for producing mammalian biopharmaceuticals with intensified DoE—a practical guide to analyses with OLS and hybrid modeling
Nold, Verena, Junghans, Lisa, Bayer, Benjamin, Bisgen, Lorenzo, Duerkop, Mark, Drerup, Raphael, Presser, Beate, Schwab, Thomas, Bluhmki, Erich, Wieschalka, Stefan, Knapp, Bettina L. · 2023 · Frontiers in Chemical Engineering · DOI
Full title: Boost dynamic protocols for producing mammalian biopharmaceuticals with intensified DoE—a practical guide to analyses with OLS and hybrid modeling
PaperA Linkage-specific Sialic Acid Labeling Strategy Reveals Different Site-specific Glycosylation Patterns in SARS-CoV-2 Spike Protein Produced in CHO and HEK Cell Substrates
Wang, Qiong, Wang, Yan, Yang, Shuang, Lin, Chang-Yi, Aliyu, Lateef, Chen, Yiqun, Parsons, Lisa M., Tian, Yuan, Jia, Hongpeng, Pekosz, Andrew, Betenbaugh, Michael J., Cipollo, John F. · 2021 · Frontiers in Chemistry · DOI
Full title: A Linkage-specific Sialic Acid Labeling Strategy Reveals Different Site-specific Glycosylation Patterns in SARS-CoV-2 Spike Protein Produced in CHO and HEK Cell Substrates
Authors: Wang, Qiong, Wang, Yan, Yang, Shuang, Lin, Chang-Yi, Aliyu, Lateef, Chen, Yiqun, Parsons, Lisa M., Tian, Yuan, Jia, Hongpeng, Pekosz, Andrew, Betenbaugh, Michael J., Cipollo, John F.
PaperDeciphering Metabolic Pathways in High-Seeding-Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective
Full title: Deciphering Metabolic Pathways in High-Seeding-Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective
PaperHigh-Level Production of scFv-Fc Antibody Using an Artificial Promoter System with Transcriptional Positive Feedback Loop of Transactivator in CHO Cells
Full title: High-Level Production of scFv-Fc Antibody Using an Artificial Promoter System with Transcriptional Positive Feedback Loop of Transactivator in CHO Cells
PaperDynamics of Amino Acid Metabolism, Gene Expression, and Circulomics in a Recombinant Chinese Hamster Ovary Cell Line Adapted to Moderate and High Levels of Extracellular Lactate
Chitwood, Dylan G., Uy, Lisa, Fu, Wanfang, Klaubert, Stephanie R., Harcum, Sarah W., Saski, Christopher · 2023 · Genes · DOI
Full title: Dynamics of Amino Acid Metabolism, Gene Expression, and Circulomics in a Recombinant Chinese Hamster Ovary Cell Line Adapted to Moderate and High Levels of Extracellular Lactate
Authors: Chitwood, Dylan G., Uy, Lisa, Fu, Wanfang, Klaubert, Stephanie R., Harcum, Sarah W., Saski, Christopher
PaperTowards Controlling the Glycoform: A Model Framework Linking Extracellular Metabolites to Antibody Glycosylation
Jedrzejewski, Philip, Val, Ioscani Jiménez del, Constantinou, Antony, Dell, Anne, Haslam, Stuart M., Polizzi, Karen M., Kontoravdi, Cleo · 2014 · International Journal of Molecular Sciences · DOI
Full title: Towards Controlling the Glycoform: A Model Framework Linking Extracellular Metabolites to Antibody Glycosylation
Authors: Jedrzejewski, Philip, Val, Ioscani Jiménez del, Constantinou, Antony, Dell, Anne, Haslam, Stuart M., Polizzi, Karen M., Kontoravdi, Cleo
Year: 2014
Venue: International Journal of Molecular Sciences
PaperHyperosmolarity Triggers the Warburg Effect in Chinese Hamster Ovary Cells and Reveals a Reduced Mitochondria Horsepower
Moreira, Jorgelindo da Veiga, Staercke, Lenny De, Martínez-Basilio, Pablo César, Gauthier-Thibodeau, Sandrine, Montégut, Léa, Schwartz, Laurent, Jolicœur, Mario · 2021 · Metabolites · DOI
Full title: Hyperosmolarity Triggers the Warburg Effect in Chinese Hamster Ovary Cells and Reveals a Reduced Mitochondria Horsepower
Authors: Moreira, Jorgelindo da Veiga, Staercke, Lenny De, Martínez-Basilio, Pablo César, Gauthier-Thibodeau, Sandrine, Montégut, Léa, Schwartz, Laurent, Jolicœur, Mario
PaperDesigning Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design
Rodríguez, Tanja Hernández, Sekulic, Anton, Lange‐Hegermann, Markus, Frahm, Björn · 2022 · Processes · DOI
Full title: Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design
Authors: Rodríguez, Tanja Hernández, Sekulic, Anton, Lange‐Hegermann, Markus, Frahm, Björn
PaperIdentification of Cell Culture Factors Influencing Afucosylation Levels in Monoclonal Antibodies by Partial Least-Squares Regression and Variable Importance Metrics
Rish, Adam J., Huang, Zhuangrong, Siddiquee, Khandaker, Xu, Jianlin, Anderson, Carl A., Borys, Michael, Khetan, Anurag · 2023 · Processes · DOI
Full title: Identification of Cell Culture Factors Influencing Afucosylation Levels in Monoclonal Antibodies by Partial Least-Squares Regression and Variable Importance Metrics
Authors: Rish, Adam J., Huang, Zhuangrong, Siddiquee, Khandaker, Xu, Jianlin, Anderson, Carl A., Borys, Michael, Khetan, Anurag
PaperAn Investigation into the Metabolic Differences between Conventional and High Seeding Density Fed-Batch Cell Cultures by Applying a Segmented Modeling Approach
Teresa Laura Krumm, Alireza Ehsani, Jochen Schaub, Fabian Stiefel · 2023 · Processes · DOI
Full title: An Investigation into the Metabolic Differences between Conventional and High Seeding Density Fed-Batch Cell Cultures by Applying a Segmented Modeling Approach
Authors: Teresa Laura Krumm, Alireza Ehsani, Jochen Schaub, Fabian Stiefel
PaperEffect of Sialic Acid on Mammalian Cell Culture and Protein Expression: A Potential Productivity Enhancer for Biopharmaceutical Cell Culture Processes
Full title: Effect of Sialic Acid on Mammalian Cell Culture and Protein Expression: A Potential Productivity Enhancer for Biopharmaceutical Cell Culture Processes
PaperOff-Gas-Based Soft Sensor for Real-Time Monitoring of Biomass and Metabolism in Chinese Hamster Ovary Cell Continuous Processes in Single-Use Bioreactors
Wallocha, Tobias, Popp, Oliver · 2021 · Processes · DOI
Full title: Off-Gas-Based Soft Sensor for Real-Time Monitoring of Biomass and Metabolism in Chinese Hamster Ovary Cell Continuous Processes in Single-Use Bioreactors
PaperOptimizing the Production of gp145, an HIV-1 Envelope Glycoprotein Vaccine Candidate and Its Encapsulation in Guanosine Microparticles
Akamine, Pearl, González‐Feliciano, José A., Almodóvar, Ruth, Morell, Gloriner, Sandoval, Javier, Capó-Vélez, Coral M., Delgado‐Vélez, Manuel, Prieto-Costas, Luis A., Madera, Bismark, Eichinger, Daniel, Pino, Ignacio, Rivera, José H., Ortiz-Ubarri, José, Rivera, José M., Baerga‐Ortiz, Abel, Lasalde‐Dominicci, José A. · 2023 · Vaccines · DOI
Full title: Optimizing the Production of gp145, an HIV-1 Envelope Glycoprotein Vaccine Candidate and Its Encapsulation in Guanosine Microparticles
Authors: Akamine, Pearl, González‐Feliciano, José A., Almodóvar, Ruth, Morell, Gloriner, Sandoval, Javier, Capó-Vélez, Coral M., Delgado‐Vélez, Manuel, Prieto-Costas, Luis A., Madera, Bismark, Eichinger, Daniel, Pino, Ignacio, Rivera, José H., Ortiz-Ubarri, José, Rivera, José M., Baerga‐Ortiz, Abel, Lasalde‐Dominicci, José A.
PaperClustering and curation of electropherograms: an efficient method for analyzing large cohorts of capillary electrophoresis glycomic profiles for bioprocessing operations
Walsh, Ian, Choo, Matthew S., Chiin, Sim Lyn, Mak, Amelia, Tay, Shi Jie, Rudd, Pauline M., Yuansheng, Yang, Choo, Andre, Ho, Ying Swan, Nguyen‐Khuong, Terry · 2020 · Beilstein Journal of Organic Chemistry · DOI
Full title: Clustering and curation of electropherograms: an efficient method for analyzing large cohorts of capillary electrophoresis glycomic profiles for bioprocessing operations
Authors: Walsh, Ian, Choo, Matthew S., Chiin, Sim Lyn, Mak, Amelia, Tay, Shi Jie, Rudd, Pauline M., Yuansheng, Yang, Choo, Andre, Ho, Ying Swan, Nguyen‐Khuong, Terry
PaperComparability Assessments of Process Changes Made during Development of Anti-Idiotype Vaccine
Luz-Hernández, Kathya de la, Rabasa, Yamilé, Montesinos, Raquel, Fuentes, Dasha, Tomás, Julio Felipe Santo, Morales, Orlando, Aguilar, Yadira, Pacheco, Brendan A, Castillo, Adolfo, Vázquez, Ana · 2014 · World Journal of Vaccines · DOI
Full title: Comparability Assessments of Process Changes Made during Development of Anti-Idiotype Vaccine
Authors: Luz-Hernández, Kathya de la, Rabasa, Yamilé, Montesinos, Raquel, Fuentes, Dasha, Tomás, Julio Felipe Santo, Morales, Orlando, Aguilar, Yadira, Pacheco, Brendan A, Castillo, Adolfo, Vázquez, Ana
ThesisInfluência do butirato de sódio, da cicloheximida e do cloreto de manganês na produtividade, glicosilação e propriedades biológicas da tireotrofina humana derivada de CHO
Ribela, Maria Teresa de Carvalho Pinto · 2014 · Theses · DOI
Full title: Influência do butirato de sódio, da cicloheximida e do cloreto de manganês na produtividade, glicosilação e propriedades biológicas da tireotrofina humana derivada de CHO
ThesisDetermination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra
Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn et al. · 2021 · Theses · DOI
Full title: Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra
ThesisUsing simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe et al. · 2016 · Theses · DOI
Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
Authors: López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe; Carrillo-Cocom, Leydi Maribel; Rocha-Pizaña, María del Refugio; Alvarez, Mario Moises
Thesis**Authors:** Kiat, Tan Hong; Yap, Miranda G.S.; Wang, Daniel I.C. **Institution:** Massachusetts Institute of Technology (MIT) **Date:** 2004-12-15T19:16:30Z
Kiat, Tan Hong; Yap, Miranda G.S.; Wang, Daniel I.C. · 2004 · Theses · DOI
Full title: **Authors:** Kiat, Tan Hong; Yap, Miranda G.S.; Wang, Daniel I.C. **Institution:** Massachusetts Institute of Technology (MIT) **Date:** 2004-12-15T19:16:30Z
Authors: Kiat, Tan Hong; Yap, Miranda G.S.; Wang, Daniel I.C.
ThesisVariations in critical quality attributes (CQAs) on therapeutic monoclonal antibodies (mAbs) due to cultivation conditions, storage conditions and external stress-factors
Full title: Variations in critical quality attributes (CQAs) on therapeutic monoclonal antibodies (mAbs) due to cultivation conditions, storage conditions and external stress-factors
ThesisProcess optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand
Full title: Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand
ThesisAssessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing
Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP] et al. · 2019 · Theses · DOI
Full title: Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing
Authors: Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP]; Deffune, Elenice; Suazo, Cláudio Alberto Torres
ThesisSobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes
Full title: Sobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes
ThesisAnti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy
Kumpel, Belinda M; Saldova, Radka; Koeleman, Carolien AM et al. · 2021 · Theses · DOI
Full title: Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy
PaperOsmoprotective effect of glycine betaine on foreign protein production in hyperosmotic recombinant chinese hamster ovary cell cultures differs among cell lines.
J. S. Ryu, Tae Kyung Kim, J. Chung, Gyun Min Lee · 2000 · Biotechnology and Bioengineering · DOI
Full title: Osmoprotective effect of glycine betaine on foreign protein production in hyperosmotic recombinant chinese hamster ovary cell cultures differs among cell lines.
Authors: J. S. Ryu, Tae Kyung Kim, J. Chung, Gyun Min Lee
PaperMethylthioadenosine (MTA) boosts cell‐specific productivities of Chinese hamster ovary cultures: dosage effects on proliferation, cell cycle and gene expression
Verhagen, Natascha, Zieringer, Julia, Takors, Ralf · 2020 · FEBS Open Bio · DOI
Full title: Methylthioadenosine (MTA) boosts cell‐specific productivities of Chinese hamster ovary cultures: dosage effects on proliferation, cell cycle and gene expression
PaperMetabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness
Sellick, Christopher, Croxford, Alexandra S., Maqsood, Arfa, Stephens, Gill, Westerhoff, Hans V., Goodacre, Royston, Dickson, Alan J. · 2015 · Biotechnology Journal · DOI
Full title: Metabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness
Authors: Sellick, Christopher, Croxford, Alexandra S., Maqsood, Arfa, Stephens, Gill, Westerhoff, Hans V., Goodacre, Royston, Dickson, Alan J.
PaperOptimization of bioprocess conditions improves production of a CHO cell-derived, bioengineered heparin.
J. Baik, Hussain Dahodwala, Eziafa I Oduah, Lee Talman, T. Gemmill, Leyla Gasimli, Payel Datta, Bo Yang, Guoyun Li, Fuming Zhang, Lingyun Li, R. Linhardt, A. Campbell, S. Gorfien, S. Sharfstein · 2015 · Biotechnology Journal · DOI
Full title: Optimization of bioprocess conditions improves production of a CHO cell-derived, bioengineered heparin.
Authors: J. Baik, Hussain Dahodwala, Eziafa I Oduah, Lee Talman, T. Gemmill, Leyla Gasimli, Payel Datta, Bo Yang, Guoyun Li, Fuming Zhang, Lingyun Li, R. Linhardt, A. Campbell, S. Gorfien, S. Sharfstein
PaperReal‐time monitoring of specific oxygen uptake rates of embryonic stem cells in a microfluidic cell culture device
Super, Alexandre, Jaccard, Nicolas, Marques, Marco P. C., Macown, Rhys J., Griffin, Lewis D., Veraitch, Farlan, Szita, Nicolas · 2016 · Biotechnology Journal · DOI
Full title: Real‐time monitoring of specific oxygen uptake rates of embryonic stem cells in a microfluidic cell culture device
Authors: Super, Alexandre, Jaccard, Nicolas, Marques, Marco P. C., Macown, Rhys J., Griffin, Lewis D., Veraitch, Farlan, Szita, Nicolas
PaperHyperosmotic stimulus study discloses benefits in ATP supply and reveals miRNA/mRNA targets to improve recombinant protein production of CHO cells.
Full title: Hyperosmotic stimulus study discloses benefits in ATP supply and reveals miRNA/mRNA targets to improve recombinant protein production of CHO cells.
PaperPolysome profiling of mAb producing CHO cell lines links translational control of cell proliferation and recombinant mRNA loading onto ribosomes with global and recombinant protein synthesis
Godfrey, Charlotte, Mead, Emma J., Daramola, Olalekan, Dunn, Sarah, Hatton, Diane, Field, Ray, Pettman, Gary, Smales, C. Mark · 2017 · Biotechnology Journal · DOI
Full title: Polysome profiling of mAb producing CHO cell lines links translational control of cell proliferation and recombinant mRNA loading onto ribosomes with global and recombinant protein synthesis
Authors: Godfrey, Charlotte, Mead, Emma J., Daramola, Olalekan, Dunn, Sarah, Hatton, Diane, Field, Ray, Pettman, Gary, Smales, C. Mark
PaperCombining Butyrated ManNAc with Glycoengineered CHO Cells Improves EPO Glycan Quality and Production.
Qiong Wang, C. Chung, Weiming Yang, Ganglong Yang, S. Chough, Yiqun Chen, Bojiao Yin, R. Bhattacharya, Yingwei Hu, Christopher T Saeui, K. Yarema, M. Betenbaugh, Hui Zhang · 2018 · Biotechnology Journal · DOI
Full title: Combining Butyrated ManNAc with Glycoengineered CHO Cells Improves EPO Glycan Quality and Production.
Authors: Qiong Wang, C. Chung, Weiming Yang, Ganglong Yang, S. Chough, Yiqun Chen, Bojiao Yin, R. Bhattacharya, Yingwei Hu, Christopher T Saeui, K. Yarema, M. Betenbaugh, Hui Zhang
PaperMulti‐Omics Reveals Impact of Cysteine Feed Concentration and Resulting Redox Imbalance on Cellular Energy Metabolism and Specific Productivity in CHO Cell Bioprocessing
Ali, Amr, Chen, Rachel, Raju, Ravali, Kshirsagar, Rashmi, Gilbert, Alan, Zang, Li, Karger, Barry L., Ivanov, Alexander R. · 2020 · Biotechnology Journal · DOI
Full title: Multi‐Omics Reveals Impact of Cysteine Feed Concentration and Resulting Redox Imbalance on Cellular Energy Metabolism and Specific Productivity in CHO Cell Bioprocessing
Authors: Ali, Amr, Chen, Rachel, Raju, Ravali, Kshirsagar, Rashmi, Gilbert, Alan, Zang, Li, Karger, Barry L., Ivanov, Alexander R.
PaperContinuous optical in‐line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency while maintaining darbepoetin alfa product quality
Full title: Continuous optical in‐line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency while maintaining darbepoetin alfa product quality
PaperReal‐time amino acid and glucose monitoring system for the automatic control of nutrient feeding in CHO cell culture using Raman spectroscopy
Domján, Júlia, Pantea, Eszter, Gyürkés, Martin, Madarász, Lajos, Kozák, Dóra, Farkas, Attila, Horváth, Balázs, Benkő, Zsuzsa, Nagy, Zsombor Kristóf, Marosi, György, Hirsch, Edit · 2022 · Biotechnology Journal · DOI
Full title: Real‐time amino acid and glucose monitoring system for the automatic control of nutrient feeding in CHO cell culture using Raman spectroscopy
PaperProduction of novel SARS‐CoV‐2 Spike truncations in Chinese hamster ovary cells leads to high expression and binding to antibodies
Minami, Shiaki A., Jung, Seongwon, Huang, Yihan, Harris, Bradley, Kenaston, Matthew W., Faller, Roland, Nandi, Somen, McDonald, Karen A., Shah, Priya S. · 2022 · Biotechnology Journal · DOI
Full title: Production of novel SARS‐CoV‐2 Spike truncations in Chinese hamster ovary cells leads to high expression and binding to antibodies
Authors: Minami, Shiaki A., Jung, Seongwon, Huang, Yihan, Harris, Bradley, Kenaston, Matthew W., Faller, Roland, Nandi, Somen, McDonald, Karen A., Shah, Priya S.
PaperComparison of mechanistic and hybrid modeling approaches for characterization of a CHO cultivation process: Requirements, pitfalls and solution paths
Bayer, Benjamin, Duerkop, Mark, Pörtner, Ralf, Möller, Johannes · 2022 · Biotechnology Journal · DOI
Full title: Comparison of mechanistic and hybrid modeling approaches for characterization of a CHO cultivation process: Requirements, pitfalls and solution paths
Authors: Bayer, Benjamin, Duerkop, Mark, Pörtner, Ralf, Möller, Johannes
PaperEnhancing recombinant protein and viral vector production in mammalian cells by targeting the YTHDF readers of <i>N</i><sup>6</sup>‐methyladenosine in mRNA
Lao, Nga T., Barron, Niall · 2023 · Biotechnology Journal · DOI
Full title: Enhancing recombinant protein and viral vector production in mammalian cells by targeting the YTHDF readers of <i>N</i><sup>6</sup>‐methyladenosine in mRNA
PaperThe impact of expression vector position on transgene transcription allows for rational expression vector design in a targeted integration system
Beal, Kathryn, Bandara, Kalpanie, Ali, Syed R., Sonak, Renuka G., Barnes, Michael R., Scarcelli, John J., Zhang, Lin · 2023 · Biotechnology Journal · DOI
Full title: The impact of expression vector position on transgene transcription allows for rational expression vector design in a targeted integration system
Authors: Beal, Kathryn, Bandara, Kalpanie, Ali, Syed R., Sonak, Renuka G., Barnes, Michael R., Scarcelli, John J., Zhang, Lin
PaperDissecting cell death pathways in fed‐batch bioreactors
Mentlak, David A., Raven, John A., Moses, Tessa, Massie, Fraser, Barber, Nicholas, Hoare, Robyn, Burton, Graeme, Young, Alison, Pybus, Leon P., Rosser, Susan J., White, Robert J., Ungár, Dániel, Bryant, Nia J. · 2023 · Biotechnology Journal · DOI
Full title: Dissecting cell death pathways in fed‐batch bioreactors
Authors: Mentlak, David A., Raven, John A., Moses, Tessa, Massie, Fraser, Barber, Nicholas, Hoare, Robyn, Burton, Graeme, Young, Alison, Pybus, Leon P., Rosser, Susan J., White, Robert J., Ungár, Dániel, Bryant, Nia J.
PaperEvaluation of NAD<sup>+</sup> precursors for improved metabolism and productivity of antibody‐producing CHO cell
Han, Hye‐Jin, Kim, Hagyeong, Yu, Hyun Gyu, Park, Jong Uk, Bae, Joo Hee, Lee, Ji Hwan, Hong, Jong Kwang, Baik, Jong Youn · 2024 · Biotechnology Journal · DOI
Full title: Evaluation of NAD<sup>+</sup> precursors for improved metabolism and productivity of antibody‐producing CHO cell
Authors: Han, Hye‐Jin, Kim, Hagyeong, Yu, Hyun Gyu, Park, Jong Uk, Bae, Joo Hee, Lee, Ji Hwan, Hong, Jong Kwang, Baik, Jong Youn
PaperEvaluation of “Difficult‐to‐Express” Monoclonal Antibodies in a CHO‐Based Hybrid Site‐Specific Integration System Under Industrially Relevant Conditions
Szkodny, Alana C., Lee, Kelvin H. · 2025 · Biotechnology Journal · DOI
Full title: Evaluation of “Difficult‐to‐Express” Monoclonal Antibodies in a CHO‐Based Hybrid Site‐Specific Integration System Under Industrially Relevant Conditions
PaperProcess parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo-Fc expressing CHO cells cultivated in controlled batch bioreactors.
Full title: Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo-Fc expressing CHO cells cultivated in controlled batch bioreactors.
PaperFed‐batch bioreactor process scale‐up from 3‐L to 2,500‐L scale for monoclonal antibody production from cell culture
Jeng-dar Yang, Canghai Lu, B. Stasny, J. Henley, Woodrow Guinto, C. González, Joseph Gleason, Monica Fung, Brett Collopy, Michael Benjamino, J. Gangi, Melissa Hanson, E. Ille · 2007 · Biotechnology and Bioengineering · DOI
Full title: Fed‐batch bioreactor process scale‐up from 3‐L to 2,500‐L scale for monoclonal antibody production from cell culture
Authors: Jeng-dar Yang, Canghai Lu, B. Stasny, J. Henley, Woodrow Guinto, C. González, Joseph Gleason, Monica Fung, Brett Collopy, Michael Benjamino, J. Gangi, Melissa Hanson, E. Ille
PaperA predictive high-throughput scale-down model of monoclonal antibody production in CHO cells.
Legmann, Rachel, Schreyer, H Brett, Combs, Rodney G, McCormick, Ellen L, Russo, A Peter, Rodgers, Seth T · 2009 · Biotechnology and bioengineering · DOI
Full title: A predictive high-throughput scale-down model of monoclonal antibody production in CHO cells.
Authors: Legmann, Rachel, Schreyer, H Brett, Combs, Rodney G, McCormick, Ellen L, Russo, A Peter, Rodgers, Seth T
PaperA multi‐pronged investigation into the effect of glucose starvation and culture duration on fed‐batch CHO cell culture
Fan, Yuzhou, Val, Ioscani Jiménez del, Müller, Christian, Lund, Anne Mathilde, Sen, Jette W., Rasmussen, Søren Kofoed, Kontoravdi, Cleo, Baycin‐Hizal, Deniz, Betenbaugh, Michael J., Weilguny, Dietmar, Andersen, Mikael Rørdam · 2015 · Biotechnology and Bioengineering · DOI
Full title: A multi‐pronged investigation into the effect of glucose starvation and culture duration on fed‐batch CHO cell culture
Authors: Fan, Yuzhou, Val, Ioscani Jiménez del, Müller, Christian, Lund, Anne Mathilde, Sen, Jette W., Rasmussen, Søren Kofoed, Kontoravdi, Cleo, Baycin‐Hizal, Deniz, Betenbaugh, Michael J., Weilguny, Dietmar, Andersen, Mikael Rørdam
PaperParallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to improve biosimilar product quality.
Brühlmann, David, Sokolov, Michael, Butté, Alessandro, Sauer, Markus, Hemberger, Jürgen, Souquet, Jonathan, Broly, Hervé, Jordan, Martin · 2017 · Biotechnology and bioengineering · DOI
Full title: Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to improve biosimilar product quality.
PaperProduction and characterization of active recombinant human factor II with consistent sialylation.
Lee, Jeong H, Reier, Jason, Heffner, Kelley M, Barton, Christopher, Spencer, David, Schmelzer, Albert E, Venkat, Raghavan · 2017 · Biotechnology and bioengineering · DOI
Full title: Production and characterization of active recombinant human factor II with consistent sialylation.
Authors: Lee, Jeong H, Reier, Jason, Heffner, Kelley M, Barton, Christopher, Spencer, David, Schmelzer, Albert E, Venkat, Raghavan
PaperAdvanced multivariate data analysis to determine the root cause of trisulfide bond formation in a novel antibody–peptide fusion
Goldrick, Stephen, Holmes, William R., Bond, Nicholas J., Lewis, Gareth, Kuiper, Marcel, Turner, Richard, Farid, Suzanne S. · 2017 · Biotechnology and Bioengineering · DOI
Full title: Advanced multivariate data analysis to determine the root cause of trisulfide bond formation in a novel antibody–peptide fusion
Authors: Goldrick, Stephen, Holmes, William R., Bond, Nicholas J., Lewis, Gareth, Kuiper, Marcel, Turner, Richard, Farid, Suzanne S.
PapercGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV‐1 envelope glycoprotein vaccine candidate
Dey, Antu, Cupo, Albert, Ozorowski, Gabriel, Sharma, Vaneet K., Behrens, Anna‐Janina, Go, Eden P., Ketas, Thomas J., Yasmeen, Anila, Klasse, Per Johan, Sayeed, Eddy, Desaire, Heather, Crispin, Max, Wilson, Ian A., Sanders, Rogier W., Hassell, Thomas M., Ward, Andrew B., Moore, John P. · 2017 · Biotechnology and Bioengineering · DOI
Full title: cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV‐1 envelope glycoprotein vaccine candidate
Authors: Dey, Antu, Cupo, Albert, Ozorowski, Gabriel, Sharma, Vaneet K., Behrens, Anna‐Janina, Go, Eden P., Ketas, Thomas J., Yasmeen, Anila, Klasse, Per Johan, Sayeed, Eddy, Desaire, Heather, Crispin, Max, Wilson, Ian A., Sanders, Rogier W., Hassell, Thomas M., Ward, Andrew B., Moore, John P.
PaperCharacterization of intact glycopeptides reveals the impact of culture media on site‐specific glycosylation of EPO‐Fc fusion protein generated by CHO‐GS cells
Qiong Wang, Ganglong Yang, Tiexin Wang, Weiming Yang, Michael J. Betenbaugh, Hui Zhang · 2019 · Biotechnology and Bioengineering · DOI
Full title: Characterization of intact glycopeptides reveals the impact of culture media on site‐specific glycosylation of EPO‐Fc fusion protein generated by CHO‐GS cells
Authors: Qiong Wang, Ganglong Yang, Tiexin Wang, Weiming Yang, Michael J. Betenbaugh, Hui Zhang
PaperImpacts of intentional mycoplasma contamination on CHO cell bioreactor cultures
Erica J. Fratz-Berilla, T. Faison, C. Kohnhorst, Sai Rashmika Velugula-Yellela, David N. Powers, K. Brorson, C. Agarabi · 2019 · Biotechnology and Bioengineering · DOI
Full title: Impacts of intentional mycoplasma contamination on CHO cell bioreactor cultures
Authors: Erica J. Fratz-Berilla, T. Faison, C. Kohnhorst, Sai Rashmika Velugula-Yellela, David N. Powers, K. Brorson, C. Agarabi
PaperCharacterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis
Chevallier, Valentine, Schoof, Erwin M., Malphettes, Laetitia, Andersen, Mikael Rørdam, Workman, Christopher T. · 2020 · Biotechnology and Bioengineering · DOI
Full title: Characterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis
Authors: Chevallier, Valentine, Schoof, Erwin M., Malphettes, Laetitia, Andersen, Mikael Rørdam, Workman, Christopher T.
PaperProduction of trimeric SARS‐CoV‐2 spike protein by CHO cells for serological COVID‐19 testing
Johari, Yusuf B., Jaffe, Stephen, Scarrott, Joseph M., Johnson, Abayomi O., Mozzanino, Théo, Pohle, Thilo H., Maisuria, Sheetal, Bhayat‐Cammack, Amina, Lambiase, Giulia, Brown, Adam, Tee, Kang Lan, Jackson, Philip J., Wong, Tuck Seng, Dickman, Mark J., Sargur, Ravishankar, James, David C. · 2020 · Biotechnology and Bioengineering · DOI
Full title: Production of trimeric SARS‐CoV‐2 spike protein by CHO cells for serological COVID‐19 testing
Authors: Johari, Yusuf B., Jaffe, Stephen, Scarrott, Joseph M., Johnson, Abayomi O., Mozzanino, Théo, Pohle, Thilo H., Maisuria, Sheetal, Bhayat‐Cammack, Amina, Lambiase, Giulia, Brown, Adam, Tee, Kang Lan, Jackson, Philip J., Wong, Tuck Seng, Dickman, Mark J., Sargur, Ravishankar, James, David C.
PaperHyperosmolality in CHO culture: Effects on cellular behavior and morphology
Romanova, Nadiya, Niemann, Tarek, Greiner, Johannes F. W., Kaltschmidt, Barbara, Kaltschmidt, Christian, Noll, Thomas · 2021 · Biotechnology and Bioengineering · DOI
Full title: Hyperosmolality in CHO culture: Effects on cellular behavior and morphology
Authors: Romanova, Nadiya, Niemann, Tarek, Greiner, Johannes F. W., Kaltschmidt, Barbara, Kaltschmidt, Christian, Noll, Thomas
PaperMulti‐omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer, and product quality
Alison P. Lee, Y. Kok, Meiyappan Lakshmanan, D. Leong, Lu Zheng, Hsueh Lee Lim, Shuwen Chen, S. Mak, Kok Siong Ang, Neil Templeton, Taha Salim, XiaoNa Wei, Eric Gifford, A. Tan, X. Bi, S. Ng, Dong-Yup Lee, W. L. Ling, Y. Ho · 2021 · Biotechnology and Bioengineering · DOI
Full title: Multi‐omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer, and product quality
Authors: Alison P. Lee, Y. Kok, Meiyappan Lakshmanan, D. Leong, Lu Zheng, Hsueh Lee Lim, Shuwen Chen, S. Mak, Kok Siong Ang, Neil Templeton, Taha Salim, XiaoNa Wei, Eric Gifford, A. Tan, X. Bi, S. Ng, Dong-Yup Lee, W. L. Ling, Y. Ho
PaperA genome‐scale nutrient minimization forecast algorithm for controlling essential amino acid levels in CHO cell cultures
Chen, Yiqun, Liu, Xiao, Anderson, Ji Young L., Naik, Harnish Mukesh, Dhara, Venkata Gayatri, Chen, Xiaolu, Harris, Glenn A., Betenbaugh, Michael J. · 2021 · Biotechnology and Bioengineering · DOI
Full title: A genome‐scale nutrient minimization forecast algorithm for controlling essential amino acid levels in CHO cell cultures
Authors: Chen, Yiqun, Liu, Xiao, Anderson, Ji Young L., Naik, Harnish Mukesh, Dhara, Venkata Gayatri, Chen, Xiaolu, Harris, Glenn A., Betenbaugh, Michael J.
PaperSoft‐sensors application for automated feeding control in high‐throughput mammalian cell cultures
Martínez‐Monge, Iván, Martínez, Carlos A., Decker, Marianne, Udugama, Isuru A., Mas, Igor Marín de, Gernaey, Krist V., Nielsen, Lars K. · 2022 · Biotechnology and Bioengineering · DOI
Full title: Soft‐sensors application for automated feeding control in high‐throughput mammalian cell cultures
Authors: Martínez‐Monge, Iván, Martínez, Carlos A., Decker, Marianne, Udugama, Isuru A., Mas, Igor Marín de, Gernaey, Krist V., Nielsen, Lars K.
PaperStrategies to control therapeutic antibody glycosylation during bioprocessing: Synthesis and separation
Edwards, Elizabeth M., Livanos, Maria, Krueger, A. P., Dell, Anne, Haslam, Stuart M., Smales, C. Mark, Bracewell, Daniel G. · 2022 · Biotechnology and Bioengineering · DOI
Full title: Strategies to control therapeutic antibody glycosylation during bioprocessing: Synthesis and separation
Authors: Edwards, Elizabeth M., Livanos, Maria, Krueger, A. P., Dell, Anne, Haslam, Stuart M., Smales, C. Mark, Bracewell, Daniel G.
PaperOptimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided by design of experiments
Schwarz, Hubert, Lee, Kevin, Castan, Andreas, Chotteau, Véronique · 2023 · Biotechnology and Bioengineering · DOI
Full title: Optimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided by design of experiments
PaperChemical inhibitors of hexokinase‐2 enzyme reduce lactate accumulation, alter glycosylation processing, and produce altered glycoforms in CHO cell cultures
Naik, Harnish Mukesh, Kumar, Swetha, Reddy, Jayanth Venkatarama, Gonzalez, Jacqueline E., McConnell, Brian O., Dhara, Venkata Gayatri, Wang, Tiexin, Yu, Marcella, Antoniewicz, Maciek R., Betenbaugh, Michael J. · 2023 · Biotechnology and Bioengineering · DOI
Full title: Chemical inhibitors of hexokinase‐2 enzyme reduce lactate accumulation, alter glycosylation processing, and produce altered glycoforms in CHO cell cultures
Authors: Naik, Harnish Mukesh, Kumar, Swetha, Reddy, Jayanth Venkatarama, Gonzalez, Jacqueline E., McConnell, Brian O., Dhara, Venkata Gayatri, Wang, Tiexin, Yu, Marcella, Antoniewicz, Maciek R., Betenbaugh, Michael J.
PaperHarnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation
Nöbel, Matthias, Barry, Craig, MacDonald, M. A., Baker, Kym, Shave, Evan, Mahler, Stephen M., Munro, Trent P., Martínez, Verónica S., Nielsen, Lars K., Marcellin, Esteban · 2023 · Biotechnology and Bioengineering · DOI
Full title: Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation
Authors: Nöbel, Matthias, Barry, Craig, MacDonald, M. A., Baker, Kym, Shave, Evan, Mahler, Stephen M., Munro, Trent P., Martínez, Verónica S., Nielsen, Lars K., Marcellin, Esteban
PaperPlatform development for high‐throughput optimization of perfusion processes—Part II: Variation of perfusion rate strategies in microwell plates
Dorn, Marie, Lucas, Ciara, Klottrup‐Rees, Kerensa, Lee, Ken, Micheletti, Martina · 2024 · Biotechnology and Bioengineering · DOI
Full title: Platform development for high‐throughput optimization of perfusion processes—Part II: Variation of perfusion rate strategies in microwell plates
PaperA Novel, Site‐Specific N‐Linked Glycosylation Model Provides Mechanistic Insights Into the Process‐Condition Dependent Distinct Fab and Fc Glycosylation of an IgG1 Monoclonal Antibody Produced by CHO VRC01 Cells
J. Reddy, Thomas Leibiger, S. Singh, Kelvin H. Lee, E. Papoutsakis, M. Ierapetritou · 2024 · Biotechnology and Bioengineering · DOI
Full title: A Novel, Site‐Specific N‐Linked Glycosylation Model Provides Mechanistic Insights Into the Process‐Condition Dependent Distinct Fab and Fc Glycosylation of an IgG1 Monoclonal Antibody Produced by CHO VRC01 Cells
Authors: J. Reddy, Thomas Leibiger, S. Singh, Kelvin H. Lee, E. Papoutsakis, M. Ierapetritou
PaperInvestigating the impact of synonymous gene recoding on a recombinantly expressed monoclonal antibody under different process parameters
Nayiri M. Kaissarian, Stephanie L. Sandefur, Arnab Ghosh, Upendra K. Katneni, Wendy Walton, Christopher C. Frye, Anton A. Komar, C. Kimchi-Sarfaty · 2025 · Bioengineering & Translational Medicine · DOI
Full title: Investigating the impact of synonymous gene recoding on a recombinantly expressed monoclonal antibody under different process parameters
Authors: Nayiri M. Kaissarian, Stephanie L. Sandefur, Arnab Ghosh, Upendra K. Katneni, Wendy Walton, Christopher C. Frye, Anton A. Komar, C. Kimchi-Sarfaty
PaperVery high density of Chinese hamster ovary cells in perfusion by alternating tangential flow or tangential flow filtration in WAVE bioreactor™—part II: Applications for antibody production and cryopreservation
Full title: Very high density of Chinese hamster ovary cells in perfusion by alternating tangential flow or tangential flow filtration in WAVE bioreactor™—part II: Applications for antibody production and cryopreservation
PaperIdentifying a robust design space for glycosylation during monoclonal antibody production.
St Amand, Melissa M, Hayes, James, Radhakrishnan, Devesh, Fernandez, Janice, Meyer, Bill, Robinson, Anne S, Ogunnaike, Babatunde A · 2016 · Biotechnology progress · DOI
Full title: Identifying a robust design space for glycosylation during monoclonal antibody production.
Authors: St Amand, Melissa M, Hayes, James, Radhakrishnan, Devesh, Fernandez, Janice, Meyer, Bill, Robinson, Anne S, Ogunnaike, Babatunde A
PaperA comparison of orbitally‐shaken and stirred‐tank bioreactors: pH modulation and bioreactor type affect CHO cell growth and protein glycosylation
D. Monteil, Valentin Juvet, Jonathan Paz, M. Moniatte, L. Baldi, D. Hacker, F. Wurm · 2016 · Biotechnology progress (Print) · DOI
Full title: A comparison of orbitally‐shaken and stirred‐tank bioreactors: pH modulation and bioreactor type affect CHO cell growth and protein glycosylation
Authors: D. Monteil, Valentin Juvet, Jonathan Paz, M. Moniatte, L. Baldi, D. Hacker, F. Wurm
PaperExploring the linkage between cell culture process parameters and downstream processing utilizing a plackett-burman design for a model monoclonal antibody.
Agarabi, Cyrus D, Chavez, Brittany K, Lute, Scott C, Read, Erik K, Rogstad, Sarah, Awotwe-Otoo, David, Brown, Matthew R, Boyne, Michael T, Brorson, Kurt A · 2017 · Biotechnology progress · DOI
Full title: Exploring the linkage between cell culture process parameters and downstream processing utilizing a plackett-burman design for a model monoclonal antibody.
Authors: Agarabi, Cyrus D, Chavez, Brittany K, Lute, Scott C, Read, Erik K, Rogstad, Sarah, Awotwe-Otoo, David, Brown, Matthew R, Boyne, Michael T, Brorson, Kurt A
PaperFluctuations in dissolved oxygen concentration during a CHO cell culture process affects monoclonal antibody productivity and the sulfhydryl-drug conjugation process.
Hippach, Michael B, Schwartz, Ian, Pei, Jian, Huynh, Jimmy, Kawai, Yasuaki, Zhu, Marie M · 2018 · Biotechnology progress · DOI
Full title: Fluctuations in dissolved oxygen concentration during a CHO cell culture process affects monoclonal antibody productivity and the sulfhydryl-drug conjugation process.
Authors: Hippach, Michael B, Schwartz, Ian, Pei, Jian, Huynh, Jimmy, Kawai, Yasuaki, Zhu, Marie M
PaperKinetic modeling as a tool to understand the influence of cell culture process parameters on the glycation of monoclonal antibody biotherapeutics.
Full title: Kinetic modeling as a tool to understand the influence of cell culture process parameters on the glycation of monoclonal antibody biotherapeutics.
PaperMultivariate data analysis of growth medium trends affecting antibody glycosylation
Powers, David N., Trunfio, Nicholas, Velugula‐Yellela, Sai Rashmika, Angart, Phillip, Faustino, Anneliese M., Agarabi, Cyrus · 2019 · Biotechnology Progress · DOI
Full title: Multivariate data analysis of growth medium trends affecting antibody glycosylation
Authors: Powers, David N., Trunfio, Nicholas, Velugula‐Yellela, Sai Rashmika, Angart, Phillip, Faustino, Anneliese M., Agarabi, Cyrus
PaperInterest of locally weighted regression to overcome nonlinear effects during in situ NIR monitoring of CHO cell culture parameters and antibody glycosylation
Zavala-Ortiz, Daniel, Ebel, Bruno, Li, Mengyao, Barradas-Dermitz, Dulce, Hayward‐Jones, Patricia M., Aguilar‐Uscanga, María Guadalupe, Marc, Annie, Guédon, Emmanuel · 2019 · Biotechnology Progress · DOI
Full title: Interest of locally weighted regression to overcome nonlinear effects during in situ NIR monitoring of CHO cell culture parameters and antibody glycosylation
Authors: Zavala-Ortiz, Daniel, Ebel, Bruno, Li, Mengyao, Barradas-Dermitz, Dulce, Hayward‐Jones, Patricia M., Aguilar‐Uscanga, María Guadalupe, Marc, Annie, Guédon, Emmanuel
PaperA class of low‐cost alternatives to kifunensine for increasing high mannose N‐linked glycosylation for monoclonal antibody production in Chinese hamster ovary cells
T. Brantley, Fernie G Mitchelson, Sarwat Khattak · 2020 · Biotechnology progress (Print) · DOI
Full title: A class of low‐cost alternatives to kifunensine for increasing high mannose N‐linked glycosylation for monoclonal antibody production in Chinese hamster ovary cells
Authors: T. Brantley, Fernie G Mitchelson, Sarwat Khattak
PaperModulation of high mannose levels in N-linked glycosylation through cell culture process conditions to increase antibody-dependent cell-mediated cytotoxicity activity for an antibody biosimilar.
Rameez, Shahid, Gowtham, Yogender K, Nayar, Gautam, Mostafa, Sigma S · 2021 · Biotechnology progress · DOI
Full title: Modulation of high mannose levels in N-linked glycosylation through cell culture process conditions to increase antibody-dependent cell-mediated cytotoxicity activity for an antibody biosimilar.
PaperDevelopment of a miniature bioreactor model to study the impact of pH and DOT fluctuations on CHO cell culture performance as a tool to understanding heterogeneity effects at large‐scale
Zakrzewski, R., Lee, Kenneth, Lye, Gary J. · 2022 · Biotechnology Progress · DOI
Full title: Development of a miniature bioreactor model to study the impact of pH and DOT fluctuations on CHO cell culture performance as a tool to understanding heterogeneity effects at large‐scale
Authors: Zakrzewski, R., Lee, Kenneth, Lye, Gary J.
PaperAn automated high inoculation density fed‐batch bioreactor, enabled through N‐1 perfusion, accommodates clonal diversity and doubles titers
Olin, Mikayla, Wolnick, Nicolas, Crittenden, Hunter, Quach, Anthony, Russell, Brian, Hendrick, Shannon, Armstrong, Julia, Webster, Thaddaeus A., Hadley, Brian C., Dickson, Marissa, Hodgkins, Jessica, Busa, Kevin, Connolly, R., Downey, Brandon · 2023 · Biotechnology Progress · DOI
Full title: An automated high inoculation density fed‐batch bioreactor, enabled through N‐1 perfusion, accommodates clonal diversity and doubles titers
PaperMultivariate data analysis of process parameters affecting the growth and productivity of stable Chinese hamster ovary cell pools expressing SARS‐CoV ‐2 spike protein as vaccine antigen in early process development
Full title: Multivariate data analysis of process parameters affecting the growth and productivity of stable Chinese hamster ovary cell pools expressing SARS‐CoV ‐2 spike protein as vaccine antigen in early process development
Full title: CHO stable pool fed‐batch process development of SARS ‐ CoV ‐2 spike protein production: Impact of aeration conditions and feeding strategies
PaperTranscriptomic responses to sodium chloride-induced osmotic stress: a study of industrial fed-batch CHO cell cultures.
Shen, Duan, Kiehl, Thomas R, Khattak, Sarwat F, Li, Zheng Jian, He, Aiqing, Kayne, Paul S, Patel, Vishal, Neuhaus, Isaac M, Sharfstein, Susan T · 2010 · Biotechnology progress · DOI
Full title: Transcriptomic responses to sodium chloride-induced osmotic stress: a study of industrial fed-batch CHO cell cultures.
Authors: Shen, Duan, Kiehl, Thomas R, Khattak, Sarwat F, Li, Zheng Jian, He, Aiqing, Kayne, Paul S, Patel, Vishal, Neuhaus, Isaac M, Sharfstein, Susan T
PaperScale-up of a monoclonal antibody CHO fed-batch production in stirred tank bioreactors: Effect of hydrodynamic conditions and feeding regimen.
Lucas Lemire, S. Reyes, Yves Durocher, R. Voyer, Olivier Henry, P. L. Pham · 2025 · Biotechnology progress (Print) · DOI
Full title: Scale-up of a monoclonal antibody CHO fed-batch production in stirred tank bioreactors: Effect of hydrodynamic conditions and feeding regimen.
Authors: Lucas Lemire, S. Reyes, Yves Durocher, R. Voyer, Olivier Henry, P. L. Pham
PaperDynamic pH profiles drive higher cell-specific and volumetric productivity.
Stephanie R Klaubert, Dylan G. Chitwood, Danqia Peng, Erin Redman, Ji Young L Anderson, N. Sandoval, S. Harcum · 2025 · Biotechnology progress (Print) · DOI
Full title: Dynamic pH profiles drive higher cell-specific and volumetric productivity.
Authors: Stephanie R Klaubert, Dylan G. Chitwood, Danqia Peng, Erin Redman, Ji Young L Anderson, N. Sandoval, S. Harcum
PaperDevelopment, characterization, and application of a 2‐Compartment system to investigate the impact of pH inhomogeneities in large‐scale CHO‐based processes
Paul, Katrin, Böttinger, Katharina, Mitic, Bernd M., Scherfler, Georg, Posch, C., Behrens, Dirk, Huber, Christian G., Herwig, Christoph · 2020 · Engineering in Life Sciences · DOI
Full title: Development, characterization, and application of a 2‐Compartment system to investigate the impact of pH inhomogeneities in large‐scale CHO‐based processes
Authors: Paul, Katrin, Böttinger, Katharina, Mitic, Bernd M., Scherfler, Georg, Posch, C., Behrens, Dirk, Huber, Christian G., Herwig, Christoph
PaperApplying intensified design of experiments to mammalian cell culture processes
Verena Nold, L. Junghans, L. Bisgen, R. Drerup, B. Presser, Ingo H Gorr, Thomas Schwab, B. Knapp, S. Wieschalka · 2021 · Engineering in Life Sciences · DOI
Full title: Applying intensified design of experiments to mammalian cell culture processes
Authors: Verena Nold, L. Junghans, L. Bisgen, R. Drerup, B. Presser, Ingo H Gorr, Thomas Schwab, B. Knapp, S. Wieschalka
PaperInvestigation and evaluation of a 3D‐printed optical modified cultivation vessel for improved scattered light measurement of biotechnologically relevant organisms
Rehfeld, J. S., Kuhnke, Louis Maximilian, Ude, Christian, John, Gernot T., Beutel, Sascha · 2023 · Engineering in Life Sciences · DOI
Full title: Investigation and evaluation of a 3D‐printed optical modified cultivation vessel for improved scattered light measurement of biotechnologically relevant organisms
Authors: Rehfeld, J. S., Kuhnke, Louis Maximilian, Ude, Christian, John, Gernot T., Beutel, Sascha
PaperInfluence of Primatone RL supplementation on sialylation of recombinant human interferon-gamma produced by Chinese hamster ovary cell culture using serum-free media.
X. Gu, Liangzhi Xie, Bryan J. Harmon, Daniel I. C. Wang · 1997 · Biotechnology and Bioengineering · DOI
Full title: Influence of Primatone RL supplementation on sialylation of recombinant human interferon-gamma produced by Chinese hamster ovary cell culture using serum-free media.
Authors: X. Gu, Liangzhi Xie, Bryan J. Harmon, Daniel I. C. Wang
PaperRole of environmental conditions on the expression levels, glycoform pattern and levels of sialyltransferase for hFSH produced by recombinant CHO cells.
Chotigeat, W, Watanapokasin, Y, Mahler, S, Gray, P P · 1994 · Cytotechnology · DOI
Full title: Role of environmental conditions on the expression levels, glycoform pattern and levels of sialyltransferase for hFSH produced by recombinant CHO cells.
Authors: Chotigeat, W, Watanapokasin, Y, Mahler, S, Gray, P P
PaperEffect of sodium butyrate on the assembly, charge variants, and galactosylation of antibody produced in recombinant Chinese hamster ovary cells
Hong, Jong Kwang, Lee, Sang‐Min, Kim, Kyung‐Yong, Lee, Gyun Min · 2014 · Applied Microbiology and Biotechnology · DOI
Full title: Effect of sodium butyrate on the assembly, charge variants, and galactosylation of antibody produced in recombinant Chinese hamster ovary cells
Authors: Hong, Jong Kwang, Lee, Sang‐Min, Kim, Kyung‐Yong, Lee, Gyun Min
PaperThe effect of hyperosmolality application time on production, quality, and biopotency of monoclonal antibodies produced in CHO cell fed-batch and perfusion cultures.
Full title: The effect of hyperosmolality application time on production, quality, and biopotency of monoclonal antibodies produced in CHO cell fed-batch and perfusion cultures.
PaperA semi-empirical glycosylation model of a camelid monoclonal antibody under hypothermia cell culture conditions
H. Aghamohseni, M. Spearman, Kaveh Ohadi, K. Braasch, M. Moo-young, M. Butler, H. Budman · 2017 · Journal of Industrial Microbiology & Biotechnology · DOI
Full title: A semi-empirical glycosylation model of a camelid monoclonal antibody under hypothermia cell culture conditions
Authors: H. Aghamohseni, M. Spearman, Kaveh Ohadi, K. Braasch, M. Moo-young, M. Butler, H. Budman
Year: 2017
Venue: Journal of Industrial Microbiology & Biotechnology
PaperCaspase activation, sialidase release and changes in sialylation pattern of recombinant human erythropoietin produced by CHO cells in batch and fed-batch cultures
Chuan, Kok Hwee, Lim, Sing Fee, Martin, Laurent, Yun, Chee Yong, Loh, Sophia O. H., Lasne, Françoise, Song, Zhiwei · 2006 · Cytotechnology · DOI
Full title: Caspase activation, sialidase release and changes in sialylation pattern of recombinant human erythropoietin produced by CHO cells in batch and fed-batch cultures
Authors: Chuan, Kok Hwee, Lim, Sing Fee, Martin, Laurent, Yun, Chee Yong, Loh, Sophia O. H., Lasne, Françoise, Song, Zhiwei
PaperBioprocess development for the production of mouse-human chimeric anti-epidermal growth factor receptor vIII antibody C12 by suspension culture of recombinant Chinese hamster ovary cells
Full title: Bioprocess development for the production of mouse-human chimeric anti-epidermal growth factor receptor vIII antibody C12 by suspension culture of recombinant Chinese hamster ovary cells
PaperEffects of clonal variation on growth, metabolism, and productivity in response to trophic factor stimulation: a study of Chinese hamster ovary cells producing a recombinant monoclonal antibody
Dahodwala, Hussain, Nowey, Mark, Митина, Т. М., Sharfstein, Susan T. · 2011 · Cytotechnology · DOI
Full title: Effects of clonal variation on growth, metabolism, and productivity in response to trophic factor stimulation: a study of Chinese hamster ovary cells producing a recombinant monoclonal antibody
Authors: Dahodwala, Hussain, Nowey, Mark, Митина, Т. М., Sharfstein, Susan T.
PaperCombination of temperature shift and hydrolysate addition regulates anti-IgE monoclonal antibody charge heterogeneity in Chinese hamster ovary cell fed-batch culture
Full title: Combination of temperature shift and hydrolysate addition regulates anti-IgE monoclonal antibody charge heterogeneity in Chinese hamster ovary cell fed-batch culture
PaperImpact of DO, agitation, aeration and copper concentration on lactate metabolism and charge heterogeneity for monoclonal antibody production by CHO cells in fed-batch culture.
Full title: Impact of DO, agitation, aeration and copper concentration on lactate metabolism and charge heterogeneity for monoclonal antibody production by CHO cells in fed-batch culture.
PaperImproved bioprocess with CHO-hTSH cells on higher microcarrier concentration provides higher overall biomass and productivity for rhTSH.
Ventini, Daniella C, Damiani, Renata, Sousa, Alvaro P B, de Oliveira, João E, Peroni, Cibele N, Ribela, Maria T C P, Bartolini, Paolo, Tonso, Aldo, Soares, Carlos R J, Pereira, Carlos A · 2011 · Applied biochemistry and biotechnology · DOI
Full title: Improved bioprocess with CHO-hTSH cells on higher microcarrier concentration provides higher overall biomass and productivity for rhTSH.
Authors: Ventini, Daniella C, Damiani, Renata, Sousa, Alvaro P B, de Oliveira, João E, Peroni, Cibele N, Ribela, Maria T C P, Bartolini, Paolo, Tonso, Aldo, Soares, Carlos R J, Pereira, Carlos A
PaperA Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering
Liang, Chenguang, Chiang, Austin W.T., Hansen, Anders Holmgaard, Arnsdorf, Johnny, Schoffelen, Sanne, Sorrentino, James T., Kellman, Benjamin P., Bao, Bokan, Voldborg, Björn G., Lewis, Nathan E. · 2020 · Current Research in Biotechnology · DOI
Full title: A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering
Authors: Liang, Chenguang, Chiang, Austin W.T., Hansen, Anders Holmgaard, Arnsdorf, Johnny, Schoffelen, Sanne, Sorrentino, James T., Kellman, Benjamin P., Bao, Bokan, Voldborg, Björn G., Lewis, Nathan E.
PaperApplication of Quality by Design to the characterization of the cell culture process of an Fc-Fusion protein.
Rouiller, Yolande, Solacroup, Thomas, Deparis, Véronique, Barbafieri, Marco, Gleixner, Ralf, Broly, Hervé, Eon-Duval, Alex · 2012 · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · DOI
Full title: Application of Quality by Design to the characterization of the cell culture process of an Fc-Fusion protein.
PaperQbD-guided pharmaceutical development of Pembrolizumab biosimilar candidate PSG-024 propelled to industry meeting primary requirements of comparability to Keytruda®.
Jaffar-Aghaei, Morteza, Khanipour, Farzad, Maghsoudi, Amir, Sarvestani, Rahim, Mohammadian, Mahdi, Maleki, Maryam, Havasi, Forugh, Rahmani, Hossein, Karagah, Amir-Hossein, Kazemali, Mohammad-Reza · 2022 · European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · DOI
Full title: QbD-guided pharmaceutical development of Pembrolizumab biosimilar candidate PSG-024 propelled to industry meeting primary requirements of comparability to Keytruda®.
PaperDecreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases.
Zhou, Meixia, Crawford, Yongping, Ng, Domingos, Tung, Jack, Pynn, Abigail F J, Meier, Angela, Yuk, Inn H, Vijayasankaran, Natarajan, Leach, Kimberly, Joly, John, Snedecor, Bradley, Shen, Amy · 2011 · Journal of biotechnology · DOI
Full title: Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases.
PaperUnderstanding the effect of increased cell specific productivity on galactosylation of monoclonal antibodies produced using Chinese hamster ovary cells.
Madabhushi, Sri R, Podtelezhnikov, Alexei A, Murgolo, Nicholas, Xu, Sen, Lin, Henry · 2021 · Journal of biotechnology · DOI
Full title: Understanding the effect of increased cell specific productivity on galactosylation of monoclonal antibodies produced using Chinese hamster ovary cells.
Authors: Madabhushi, Sri R, Podtelezhnikov, Alexei A, Murgolo, Nicholas, Xu, Sen, Lin, Henry
PaperGenome-scale metabolic analysis reveals enhanced metabolism and antioxidative stress response in perfusion cell culture under constant hyperosmotic stimulation.
Ran, Qingyuan, Zhang, Xinran, Wang, Chen, Zhang, Weijian, Zhao, Liang, Tan, Wen-Song, Ye, Qian · 2025 · Journal of biotechnology · DOI
Full title: Genome-scale metabolic analysis reveals enhanced metabolism and antioxidative stress response in perfusion cell culture under constant hyperosmotic stimulation.
PaperChemometrics and in-line near infrared spectroscopic monitoring of a biopharmaceutical Chinese hamster ovary cell culture: prediction of multiple cultivation variables.
Clavaud, Matthieu, Roggo, Yves, Von Daeniken, Ralph, Liebler, André, Schwabe, Jan-Oliver · 2013 · Talanta · DOI
Full title: Chemometrics and in-line near infrared spectroscopic monitoring of a biopharmaceutical Chinese hamster ovary cell culture: prediction of multiple cultivation variables.
PaperIdentification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening.
Kim, Su Hyun, Shin, Seunghyeon, Baek, Minhye, Xiong, Kai, Karottki, Karen Julie la Cour, Hefzi, Hooman, Grav, Lise Marie, Pedersen, Lasse Ebdrup, Kildegaard, Helene Faustrup, Lewis, Nathan E, Lee, Jae Seong, Lee, Gyun Min · 2023 · Metabolic engineering · DOI
Full title: Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening.
Authors: Kim, Su Hyun, Shin, Seunghyeon, Baek, Minhye, Xiong, Kai, Karottki, Karen Julie la Cour, Hefzi, Hooman, Grav, Lise Marie, Pedersen, Lasse Ebdrup, Kildegaard, Helene Faustrup, Lewis, Nathan E, Lee, Jae Seong, Lee, Gyun Min
PaperCompartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells
Pérez-Rodríguez, Saumel, Wulff, Tune, Voldborg, Björn G., Altamirano, Claudia, Trujillo‐Roldán, Mauricio A., Valdez‐Cruz, Norma A. · 2021 · ACS Omega · DOI
Full title: Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells
Authors: Pérez-Rodríguez, Saumel, Wulff, Tune, Voldborg, Björn G., Altamirano, Claudia, Trujillo‐Roldán, Mauricio A., Valdez‐Cruz, Norma A.
PaperEffect of pH, temperature, and salt on the stability of Escherichia coli- and Chinese hamster ovary cell-derived IgG1 Fc.
Cynthia H Li, L. Narhi, J. Wen, Mariana N. Dimitrova, Z. Wen, Jenny Li, Joey Pollastrini, X. Nguyen, T. Tsuruda, Yijia Jiang · 2012 · Biochemistry · DOI
Full title: Effect of pH, temperature, and salt on the stability of Escherichia coli- and Chinese hamster ovary cell-derived IgG1 Fc.
Authors: Cynthia H Li, L. Narhi, J. Wen, Mariana N. Dimitrova, Z. Wen, Jenny Li, Joey Pollastrini, X. Nguyen, T. Tsuruda, Yijia Jiang
PaperOsmoprotective Effect of Glycine Betaine on Thrombopoietin Production in Hyperosmotic Chinese Hamster Ovary Cell Culture: Clonal Variations
Tae Kyung Kim, J. S. Ryu, J. Chung, Min Soo Kim, G. Lee · 2000 · Biotechnology progress (Print) · DOI
Full title: Osmoprotective Effect of Glycine Betaine on Thrombopoietin Production in Hyperosmotic Chinese Hamster Ovary Cell Culture: Clonal Variations
Authors: Tae Kyung Kim, J. S. Ryu, J. Chung, Min Soo Kim, G. Lee
PaperControl of culture environment for improved polyethylenimine-mediated transient production of recombinant monoclonal antibodies by CHO cells.
Galbraith, Douglas J, Tait, Andrew S, Racher, Andrew J, Birch, John R, James, David C · 2006 · Biotechnology progress · DOI
Full title: Control of culture environment for improved polyethylenimine-mediated transient production of recombinant monoclonal antibodies by CHO cells.
Authors: Galbraith, Douglas J, Tait, Andrew S, Racher, Andrew J, Birch, John R, James, David C
PaperStructural and functional analysis of the canine histamine H2 receptor by site-directed mutagenesis: N-glycosylation is not vital for its action
Fukushima, Yasushi, Oka, Y., Saitoh, T., Katagiri, Hideki, Asano, Tomoichiro, Matsuhashi, Nobuyuki, Takata, Kei‐ichi, Breda, Eric van, Yazaki, Y, Sugano, Kentaro · 1995 · Biochemical Journal · DOI
Full title: Structural and functional analysis of the canine histamine H2 receptor by site-directed mutagenesis: N-glycosylation is not vital for its action
Authors: Fukushima, Yasushi, Oka, Y., Saitoh, T., Katagiri, Hideki, Asano, Tomoichiro, Matsuhashi, Nobuyuki, Takata, Kei‐ichi, Breda, Eric van, Yazaki, Y, Sugano, Kentaro
McAlister, M., Brown, Marion H., Willis, Antony C., Rudd, Pauline M., Harvey, David J., Aplin, Robin T., Shotton, David M., Dwek, Raymond A., Barclay, A. Neil, Driscoll, Paul C. · 1998 · European Journal of Biochemistry · DOI
Full title: Structural analysis of the CD5 antigen
Authors: McAlister, M., Brown, Marion H., Willis, Antony C., Rudd, Pauline M., Harvey, David J., Aplin, Robin T., Shotton, David M., Dwek, Raymond A., Barclay, A. Neil, Driscoll, Paul C.
PaperChemical polysialylation of human recombinant butyrylcholinesterase delivers a long-acting bioscavenger for nerve agents in vivo
Ilyushin, D. G., Smirnov, I. V., Belogurov, Alexey A., Dyachenko, I. A., Жармухамедова, Т. Ю., Novozhilova, T. I., Bychikhin, E. A., Serebryakova, Marina V., Kharybin, Oleg N., Мурашев, Аркадий Н., Anikienko, K. A., Николаев, Е. Н., Пономаренко, Н. А., Genkin, Dmitry, Blackburn, G. Michael, Masson, Patrick, Gabibov, Alexander G. · 2013 · Proceedings of the National Academy of Sciences · DOI
Full title: Chemical polysialylation of human recombinant butyrylcholinesterase delivers a long-acting bioscavenger for nerve agents in vivo
Authors: Ilyushin, D. G., Smirnov, I. V., Belogurov, Alexey A., Dyachenko, I. A., Жармухамедова, Т. Ю., Novozhilova, T. I., Bychikhin, E. A., Serebryakova, Marina V., Kharybin, Oleg N., Мурашев, Аркадий Н., Anikienko, K. A., Николаев, Е. Н., Пономаренко, Н. А., Genkin, Dmitry, Blackburn, G. Michael, Masson, Patrick, Gabibov, Alexander G.
Year: 2013
Venue: Proceedings of the National Academy of Sciences
PaperDiscovery and Investigation of Misincorporation of Serine at Asparagine Positions in Recombinant Proteins Expressed in Chinese Hamster Ovary Cells
Wen, Dingyi, Vecchi, Malgorzata M., Gu, Sheng, Su, Lihe, Dolníková, Jana, Huang, Yao‐ming, Foley, Susan F., Garber, Ellen A., Pederson, Nels E., Meier, Werner · 2009 · Journal of Biological Chemistry · DOI
Full title: Discovery and Investigation of Misincorporation of Serine at Asparagine Positions in Recombinant Proteins Expressed in Chinese Hamster Ovary Cells
Authors: Wen, Dingyi, Vecchi, Malgorzata M., Gu, Sheng, Su, Lihe, Dolníková, Jana, Huang, Yao‐ming, Foley, Susan F., Garber, Ellen A., Pederson, Nels E., Meier, Werner
PaperGlycomics Profiling of Chinese Hamster Ovary Cell Glycosylation Mutants Reveals N-Glycans of a Novel Size and Complexity*
S. North, Hung‐Hsiang Huang, S. Sundaram, Jihye Jang-Lee, A. Etienne, Alana Trollope, Sara Chalabi, A. Dell, P. Stanley, S. Haslam · 2009 · Journal of Biological Chemistry · DOI
Full title: Glycomics Profiling of Chinese Hamster Ovary Cell Glycosylation Mutants Reveals N-Glycans of a Novel Size and Complexity*
Authors: S. North, Hung‐Hsiang Huang, S. Sundaram, Jihye Jang-Lee, A. Etienne, Alana Trollope, Sara Chalabi, A. Dell, P. Stanley, S. Haslam
PaperO-Glycan Sialylation and the Structure of the Stalk-like Region of the T Cell Co-receptor CD8*
A. Merry, R. Gilbert, D. Shore, L. Royle, O. Miroshnychenko, M. Vuong, M. Wormald, D. Harvey, R. Dwek, B. Classon, P. Rudd, S. Davis · 2003 · Journal of Biological Chemistry · DOI
Full title: O-Glycan Sialylation and the Structure of the Stalk-like Region of the T Cell Co-receptor CD8*
Authors: A. Merry, R. Gilbert, D. Shore, L. Royle, O. Miroshnychenko, M. Vuong, M. Wormald, D. Harvey, R. Dwek, B. Classon, P. Rudd, S. Davis
PaperNovel Poly-GalNAcβ1–4GlcNAc (LacdiNAc) and Fucosylated Poly-LacdiNAc N-Glycans from Mammalian Cells Expressing β1,4-N-Acetylgalactosaminyltransferase and α1,3-Fucosyltransferase
Kawar, Ziad, Haslam, Stuart M., Morris, Howard R., Dell, Anne, Cummings, Richard D. · 2005 · Journal of Biological Chemistry · DOI
Full title: Novel Poly-GalNAcβ1–4GlcNAc (LacdiNAc) and Fucosylated Poly-LacdiNAc N-Glycans from Mammalian Cells Expressing β1,4-N-Acetylgalactosaminyltransferase and α1,3-Fucosyltransferase
Authors: Kawar, Ziad, Haslam, Stuart M., Morris, Howard R., Dell, Anne, Cummings, Richard D.
PaperEnhancement of anti-TNFα monoclonal antibody production in CHO cells through the use of UCOE and DHFR elements in vector construction and the optimization of cell culture media
Chung, Đoàn Chính, Ho, Chi Nguyen Quynh, Nguyen, Thi Thuy, Nguyen, Thi Phuong Thao, Giáp, Đỗ Đăng, Hoang, Nghia Son, Long, Lê Thành · 2021 · Preparative Biochemistry & Biotechnology · DOI
Full title: Enhancement of anti-TNFα monoclonal antibody production in CHO cells through the use of UCOE and DHFR elements in vector construction and the optimization of cell culture media
Authors: Chung, Đoàn Chính, Ho, Chi Nguyen Quynh, Nguyen, Thi Thuy, Nguyen, Thi Phuong Thao, Giáp, Đỗ Đăng, Hoang, Nghia Son, Long, Lê Thành
PaperNutrient supplementation strategy improves cell concentration and longevity, monoclonal antibody production and lactate metabolism of Chinese hamster ovary cells
Pérez-Rodríguez, Saumel, Ramírez-Lira, María de Jesús, Trujillo‐Roldán, Mauricio A., Valdez‐Cruz, Norma A. · 2020 · Bioengineered · DOI
Full title: Nutrient supplementation strategy improves cell concentration and longevity, monoclonal antibody production and lactate metabolism of Chinese hamster ovary cells
Authors: Pérez-Rodríguez, Saumel, Ramírez-Lira, María de Jesús, Trujillo‐Roldán, Mauricio A., Valdez‐Cruz, Norma A.
PaperEffect of altered CH2-associated carbohydrate structure on the functional properties and in vivo fate of chimeric mouse-human immunoglobulin G1
A. Wright, Sherie L. Morrison · 1994 · Journal of Experimental Medicine · DOI
Full title: Effect of altered CH2-associated carbohydrate structure on the functional properties and in vivo fate of chimeric mouse-human immunoglobulin G1
PaperIncorporation of 15N from ammonium into the N-linked oligosaccharides of an immunoadhesin glycoprotein expressed in Chinese hamster ovary cells
Gawlitzek, Martin, Papac, Damon I., Sliwkowski, Mary B., Ryll, Thomas · 1999 · Glycobiology · DOI
Full title: Incorporation of 15N from ammonium into the N-linked oligosaccharides of an immunoadhesin glycoprotein expressed in Chinese hamster ovary cells
Authors: Gawlitzek, Martin, Papac, Damon I., Sliwkowski, Mary B., Ryll, Thomas
PaperOligosaccharides modulate the apoptotic activity of glycodelin
Jayachandran, Rajesh, Radcliffe, Catherine M., Royle, Louise, Harvey, David J., Dwek, Raymond A., Rudd, Pauline M., Karande, Anjali A. · 2006 · Glycobiology · DOI
Full title: Oligosaccharides modulate the apoptotic activity of glycodelin
Authors: Jayachandran, Rajesh, Radcliffe, Catherine M., Royle, Louise, Harvey, David J., Dwek, Raymond A., Rudd, Pauline M., Karande, Anjali A.
PaperAnalysis of coagulation factor IX in bioreactor cell culture medium predicts yield and quality of the purified product
Zacchi, Lucía F., Recinos, Dinora Roche, Pegg, Cassandra L., Phung, Toan K., Napoli, Mark, Aitken, Campbell, Sandford, Vanessa, Mahler, Stephen M., Lee, Yih Yean, Schulz, Benjamin L., Howard, Christopher B. · 2020 · DOI
Full title: Analysis of coagulation factor IX in bioreactor cell culture medium predicts yield and quality of the purified product
Authors: Zacchi, Lucía F., Recinos, Dinora Roche, Pegg, Cassandra L., Phung, Toan K., Napoli, Mark, Aitken, Campbell, Sandford, Vanessa, Mahler, Stephen M., Lee, Yih Yean, Schulz, Benjamin L., Howard, Christopher B.
PaperComparing Kinetic versus Stoichiometric Priorities in Hybrid Models of CHO Metabolism
Khare, Pratik, Ndahiro, Nelson, Klaubert, Stephanie R., Ma, Edward, Bertalan, Tom, Kevrekidis, Ioannis G., Harcum, Sarah W., Betenbaugh, Michael J. · 2025 · DOI
Full title: Comparing Kinetic versus Stoichiometric Priorities in Hybrid Models of CHO Metabolism
Authors: Khare, Pratik, Ndahiro, Nelson, Klaubert, Stephanie R., Ma, Edward, Bertalan, Tom, Kevrekidis, Ioannis G., Harcum, Sarah W., Betenbaugh, Michael J.
PaperN‐glycosylation regulates MET processing and signaling
Atsushi Saitou, Y. Hasegawa, N. Fujitani, S. Ariki, Y. Uehara, Ukichiro Hashimoto, A. Saito, K. Kuronuma, Kunio Matsumoto, H. Chiba, Motoko Takahashi · 2022 · Cancer Science · DOI
Full title: N‐glycosylation regulates MET processing and signaling
Authors: Atsushi Saitou, Y. Hasegawa, N. Fujitani, S. Ariki, Y. Uehara, Ukichiro Hashimoto, A. Saito, K. Kuronuma, Kunio Matsumoto, H. Chiba, Motoko Takahashi
PaperStructural studies of the carbohydrate chains of human gamma-interferon
MUTSAERS, Johanna H. G. M., Kamerling, Johannis P., Devos, René, Guisez, Yves, Fiers, Walter, Vliegenthart, Johannes F.G. · 1986 · European Journal of Biochemistry · DOI
Full title: Structural studies of the carbohydrate chains of human gamma-interferon
Authors: MUTSAERS, Johanna H. G. M., Kamerling, Johannis P., Devos, René, Guisez, Yves, Fiers, Walter, Vliegenthart, Johannes F.G.
PaperIsolation and structure determination of the intact sialylated N‐linked carbohydrate chains of recombinant human follitropin expressed in Chinese hamster ovary cells
Hård, Karl, Mekking, A., DAMM, Jan B. L., Kamerling, Johannis P., Boer, W. de, Wijnands, Robert A., VLIEGENTHART, Johannes F. G. · 1990 · European Journal of Biochemistry · DOI
Full title: Isolation and structure determination of the intact sialylated N‐linked carbohydrate chains of recombinant human follitropin expressed in Chinese hamster ovary cells
Authors: Hård, Karl, Mekking, A., DAMM, Jan B. L., Kamerling, Johannis P., Boer, W. de, Wijnands, Robert A., VLIEGENTHART, Johannes F. G.
PaperThe macroheterogeneity of recombinant human interferon‐gamma produced by Chinese‐hamster ovary cells is affected by the protein and lipid content of the culture medium
Castro Pm, Ison Ap, Hayter Pm, Bull At · 1995 · Biotechnology and applied biochemistry · DOI
Full title: The macroheterogeneity of recombinant human interferon‐gamma produced by Chinese‐hamster ovary cells is affected by the protein and lipid content of the culture medium
PaperCell-specific posttranslational events affect functional expression at the plasma membrane but not tetrodotoxin sensitivity of the rat brain IIA sodium channel alpha-subunit expressed in mammalian cells
Xc, Yang, Labarca, Cesar, Nargeot, Joël, HO, B. Samuel, Elroy‐Stein, Orna, Moss, Bernard, Davidson, Norman, Lester, HA · 1992 · Journal of Neuroscience · DOI
Full title: Cell-specific posttranslational events affect functional expression at the plasma membrane but not tetrodotoxin sensitivity of the rat brain IIA sodium channel alpha-subunit expressed in mammalian cells
Authors: Xc, Yang, Labarca, Cesar, Nargeot, Joël, HO, B. Samuel, Elroy‐Stein, Orna, Moss, Bernard, Davidson, Norman, Lester, HA
PaperApplication of liquid chromatography-mass spectrometry-based protein and proteomic analytical approaches to chinese hamster ovary cell based industrial biopharmaceutical production
Full title: Application of liquid chromatography-mass spectrometry-based protein and proteomic analytical approaches to chinese hamster ovary cell based industrial biopharmaceutical production
PaperFACTORS AFFECTING CHINESE HAMSTER OVARY CELL PROLIFERATION AND VIABILITY
Reķēna, Alīna, Livkisa, Dora, Loča, Dagnija · 2019 · Environment Technology Resources Proceedings of the International Scientific and Practical Conference · DOI
Full title: FACTORS AFFECTING CHINESE HAMSTER OVARY CELL PROLIFERATION AND VIABILITY
PaperMicroevolutionary dynamics of eccDNA in Chinese hamster ovary cells grown in fed-batch cultures under control and lactate-stressed conditions
Chitwood, Dylan G., Wang, Qinghua, Klaubert, Stephanie R., Green, Kiana, Wu, Cathy, Harcum, Sarah W., Saski, Christopher · 2022 · Research Square (Research Square) · DOI
Full title: Microevolutionary dynamics of eccDNA in Chinese hamster ovary cells grown in fed-batch cultures under control and lactate-stressed conditions
Authors: Chitwood, Dylan G., Wang, Qinghua, Klaubert, Stephanie R., Green, Kiana, Wu, Cathy, Harcum, Sarah W., Saski, Christopher
PaperNew high-throughput screening method for Chinese hamster ovary cell lines expressing low reduced monoclonal antibody levels: Application of a system controlling the gas phase over cell lysates in miniature bioreactors and facilitating multiple sample setup
Full title: New high-throughput screening method for Chinese hamster ovary cell lines expressing low reduced monoclonal antibody levels: Application of a system controlling the gas phase over cell lysates in miniature bioreactors and facilitating multiple sample setup
PaperConsequences of Soluble ICAM-1 N-Glycan Alterations on Receptor Binding and Signaling Kinetics in Mouse Astrocytes
Schürpf, Thomas, Callewaert, Nico, Meyer, Matthias J. T., Tränkle, Christian, Laroy, Wouter, Cummings, Richard D., Otto, Vivianne I. · 2008 · Open Glycoscience · DOI
Full title: Consequences of Soluble ICAM-1 N-Glycan Alterations on Receptor Binding and Signaling Kinetics in Mouse Astrocytes
Authors: Schürpf, Thomas, Callewaert, Nico, Meyer, Matthias J. T., Tränkle, Christian, Laroy, Wouter, Cummings, Richard D., Otto, Vivianne I.
PaperAn Improved Cell Culture Process for Production of Omalizumab
Bhavsar, Kaumil, Joshi, Kasuhal, Patel, Ghanshyam, Vaishnav, Parth, Narayan, Om, Sharma, Abhishek, Katrodiya, Hetal, Dave, Vivek, Rawal, C. M. · 2023 · Journal of Drug Delivery and Therapeutics · DOI
Full title: An Improved Cell Culture Process for Production of Omalizumab
Authors: Bhavsar, Kaumil, Joshi, Kasuhal, Patel, Ghanshyam, Vaishnav, Parth, Narayan, Om, Sharma, Abhishek, Katrodiya, Hetal, Dave, Vivek, Rawal, C. M.
PaperProduction of Trimeric SARS-CoV-2 Spike Protein by CHO Cells for Serological COVID-19 Testing
Johari, Yusuf B., Jaffe, Stephen, Scarrott, Joseph M., Johnson, Abayomi O., Mozzanino, Th o, Pohle, Thilo H., Maisuria, Sheetal, Cammack, Amina Bhayat, Brown, Adam, Tee, Kang Lan, Jackson, Philip J., Wong, Tuck Seng, Dickman, M. M., Sargur, Ravishankar, James, David C. · 2020 · DOI
Full title: Production of Trimeric SARS-CoV-2 Spike Protein by CHO Cells for Serological COVID-19 Testing
Authors: Johari, Yusuf B., Jaffe, Stephen, Scarrott, Joseph M., Johnson, Abayomi O., Mozzanino, Th o, Pohle, Thilo H., Maisuria, Sheetal, Cammack, Amina Bhayat, Brown, Adam, Tee, Kang Lan, Jackson, Philip J., Wong, Tuck Seng, Dickman, M. M., Sargur, Ravishankar, James, David C.
PaperUsing MVDA with Stoichiometric Balances to Optimize Amino Acid Concentrations in Chemically Defined CHO Cell Culture Medium for Improved Culture Performance
Salim, Taha, Chauhan, Gaurav, Templeton, Neil, Ling, Wai Lam W. · 2021 · DOI
Full title: Using MVDA with Stoichiometric Balances to Optimize Amino Acid Concentrations in Chemically Defined CHO Cell Culture Medium for Improved Culture Performance
PaperIntracellular CHO cell metabolite profiling and in vivo monitoring of redox state unravel the effect of temperature downshift on cell growth, antibody titer and product quality
Full title: Intracellular CHO cell metabolite profiling and in vivo monitoring of redox state unravel the effect of temperature downshift on cell growth, antibody titer and product quality
PaperShortening the Biologics Clinical Timeline with a Novel Method for Generating Stable, High Producing Cell Pools and Clones
Hall, Chad A., Kravitz, Rachel H., Johnson, Karl F., Sanek, Nicholas A., Maiti, Payel, Ziemba, Keith R., Liu, Jia, Andreev, Dmitri O., Chrostowski, Victoria L., Collins, Ian J., Bleck, Gregory T. · 2022 · DOI
Full title: Shortening the Biologics Clinical Timeline with a Novel Method for Generating Stable, High Producing Cell Pools and Clones
Authors: Hall, Chad A., Kravitz, Rachel H., Johnson, Karl F., Sanek, Nicholas A., Maiti, Payel, Ziemba, Keith R., Liu, Jia, Andreev, Dmitri O., Chrostowski, Victoria L., Collins, Ian J., Bleck, Gregory T.
PaperUnderstanding the impact of bioprocess conditions on monoclonal antibody glycosylation in mammalian cell cultures through experimental and computational analyses
Sou, Si Nga · 2015 · Spiral (Imperial College London) · DOI
Full title: Understanding the impact of bioprocess conditions on monoclonal antibody glycosylation in mammalian cell cultures through experimental and computational analyses
PaperExpanding the understanding of viral tropism by characterizing the N-glycomic profiles of transducible cell lines and tissue types and Characterizing functional receptors that mediate the inhibitory relationship between 4-O-sulfated chondroitin sulfate and neurons
Full title: Expanding the understanding of viral tropism by characterizing the N-glycomic profiles of transducible cell lines and tissue types and Characterizing functional receptors that mediate the inhibitory relationship between 4-O-sulfated chondroitin sulfate and neurons
PaperEnhancing Recombinant Monoclonal Antibody Production in CHO Cell Cultures: Leveraging the Power of Multivariate Analysis and Chemical Additives in Upstream Bioprocessing
Full title: Enhancing Recombinant Monoclonal Antibody Production in CHO Cell Cultures: Leveraging the Power of Multivariate Analysis and Chemical Additives in Upstream Bioprocessing
PaperSemi-Automated Glycoproteomic Data Analysis of LC-MS Data Using GlycopeptideGraphMS in Process Development of Monoclonal Antibody Biologics
Pang, Kuin Tian, Tay, Shi Jie, Wan, Corrine, Walsh, Ian, Choo, Matthew S., Yang, Yuansheng, Choo, Andre, Ho, Ying Swan, Nguyen‐Khuong, Terry · 2021 · Frontiers in Chemistry · DOI
Full title: Semi-Automated Glycoproteomic Data Analysis of LC-MS Data Using GlycopeptideGraphMS in Process Development of Monoclonal Antibody Biologics
Authors: Pang, Kuin Tian, Tay, Shi Jie, Wan, Corrine, Walsh, Ian, Choo, Matthew S., Yang, Yuansheng, Choo, Andre, Ho, Ying Swan, Nguyen‐Khuong, Terry
PaperUse of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells
Velugula‐Yellela, Sai Rashmika, Kohnhorst, Casey, Powers, David N., Trunfio, Nicholas, Faustino, Anneliese M., Angart, Phillip, Berilla, Erica, Faison, Talia, Agarabi, Cyrus · 2018 · Journal of Visualized Experiments · DOI
Full title: Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells
Authors: Velugula‐Yellela, Sai Rashmika, Kohnhorst, Casey, Powers, David N., Trunfio, Nicholas, Faustino, Anneliese M., Angart, Phillip, Berilla, Erica, Faison, Talia, Agarabi, Cyrus
PaperPurification and Analytics of a Monoclonal Antibody from Chinese Hamster Ovary Cells Using an Automated Microbioreactor System.
Sai Rashmika Velugula-Yellela, David N. Powers, Phillip Angart, Anneliese M. Faustino, T. Faison, C. Kohnhorst, Erica J. Fratz-Berilla, C. Agarabi · 2019 · Journal of Visualized Experiments · DOI
Full title: Purification and Analytics of a Monoclonal Antibody from Chinese Hamster Ovary Cells Using an Automated Microbioreactor System.
Authors: Sai Rashmika Velugula-Yellela, David N. Powers, Phillip Angart, Anneliese M. Faustino, T. Faison, C. Kohnhorst, Erica J. Fratz-Berilla, C. Agarabi
PaperRapid Antibody Glycoengineering in Chinese Hamster Ovary Cells
Marbiah, Masue, Kotidis, Pavlos, Donini, Roberto, Gómez, Itzcóatl A., Val, Ioscani Jiménez del, Haslam, Stuart M., Polizzi, Karen M., Kontoravdi, Cleo · 2022 · Journal of Visualized Experiments · DOI
Full title: Rapid Antibody Glycoengineering in Chinese Hamster Ovary Cells
Authors: Marbiah, Masue, Kotidis, Pavlos, Donini, Roberto, Gómez, Itzcóatl A., Val, Ioscani Jiménez del, Haslam, Stuart M., Polizzi, Karen M., Kontoravdi, Cleo
PaperStudy on Interactions between Fed-Batch and Batch Operating Parameters for the Development of Monoclonal Antibody Fed-Batch using Design of Experiments
Raja, Junaid Muneer · 2014 · Journal of Bioprocessing & Biotechniques · DOI
Full title: Study on Interactions between Fed-Batch and Batch Operating Parameters for the Development of Monoclonal Antibody Fed-Batch using Design of Experiments
PaperAdvances in Genetic Engineering & Biotechnology
Kim, Yeon-Gu · 2012
Full title: Advances in Genetic Engineering & Biotechnology
Authors: Kim, Yeon-Gu
Year: 2012
PaperAmélioration de la production et de la qualité des protéines thérapeutiques recombinantes produites en culture en mode cuvée-alimentée de cellules de mammifère
Karengera, Eric · 2017 · PolyPublie (École Polytechnique de Montréal)
Full title: Amélioration de la production et de la qualité des protéines thérapeutiques recombinantes produites en culture en mode cuvée-alimentée de cellules de mammifère
Authors: Karengera, Eric
Year: 2017
Venue: PolyPublie (École Polytechnique de Montréal)
PaperAn investigation into factors that cause inhibition of the growth of animal cells In Vitro
O'Toole, Angela · 1997 · Dublin City University Open Access Institutional Repository (Dublin City University)
Full title: An investigation into factors that cause inhibition of the growth of animal cells In Vitro
Authors: O'Toole, Angela
Year: 1997
Venue: Dublin City University Open Access Institutional Repository (Dublin City University)
PaperChemically modified cysteine in fed-batch processes and impact on CHO specific productivity
Zimmer, Aline · 2015 · Journal of Biotechnology & Biomaterials
Full title: Chemically modified cysteine in fed-batch processes and impact on CHO specific productivity
Authors: Zimmer, Aline
Year: 2015
Venue: Journal of Biotechnology & Biomaterials
PaperCloning, Sequencing and Expression of a Porcine Intestinal Peptide Transporter in a Mammalian Cell Line
Klang, J. E. · 2002 · VTechWorks (Virginia Tech)
Full title: Cloning, Sequencing and Expression of a Porcine Intestinal Peptide Transporter in a Mammalian Cell Line
Authors: Klang, J. E.
Year: 2002
Venue: VTechWorks (Virginia Tech)
PaperComprehensive Characterization of an Inducible Mammalian Expression System Using 13C-Metabolic Flux Analysis
Sheikholeslami, Zahra · 2013 · PolyPublie (École Polytechnique de Montréal)
Full title: Comprehensive Characterization of an Inducible Mammalian Expression System Using 13C-Metabolic Flux Analysis
Authors: Sheikholeslami, Zahra
Year: 2013
Venue: PolyPublie (École Polytechnique de Montréal)
PaperContinuous flow synthesis of chemical building blocks for biological application
Jong, Thing Soon · 2014 · Edinburgh Research Archive (University of Edinburgh)
Full title: Continuous flow synthesis of chemical building blocks for biological application
Authors: Jong, Thing Soon
Year: 2014
Venue: Edinburgh Research Archive (University of Edinburgh)
PaperControl of Key Parameters in Developing Mammalian Production Clones
R. Kunert, S. Wolbank, M. Chang, R. Voglauer, N. Borth, H. Katinger · 2004
Full title: Control of Key Parameters in Developing Mammalian Production Clones
Authors: R. Kunert, S. Wolbank, M. Chang, R. Voglauer, N. Borth, H. Katinger
Year: 2004
PaperDevelopment and application of quantitative liquid chromatography – mass spectrometry techniques to facilitate enhanced bioprocessing of therapeutic proteins
Farrell, Amy · 2016
Full title: Development and application of quantitative liquid chromatography – mass spectrometry techniques to facilitate enhanced bioprocessing of therapeutic proteins
Authors: Farrell, Amy
Year: 2016
PaperDevelopment of a Dynamic Model to Describe CHO cells Metabolic Network and Regulation
Ghorbaniaghdam, Atefeh · 2013 · PolyPublie (École Polytechnique de Montréal)
Full title: Development of a Dynamic Model to Describe CHO cells Metabolic Network and Regulation
Authors: Ghorbaniaghdam, Atefeh
Year: 2013
Venue: PolyPublie (École Polytechnique de Montréal)
PaperDevelopment of DNA and recombinant vaccines against toxoplasma gondii infection / Ching Xiao Teng
Ching, Xiao Teng · 2016
Full title: Development of DNA and recombinant vaccines against toxoplasma gondii infection / Ching Xiao Teng
Authors: Ching, Xiao Teng
Year: 2016
PaperDevelopment of Soft Sensors for Monitoring of Chinese Hamster Ovary Cell Processes
Ohadi, Seyed Kaveh · 2014 · UWSpace (University of Waterloo)
Full title: Development of Soft Sensors for Monitoring of Chinese Hamster Ovary Cell Processes
Authors: Ohadi, Seyed Kaveh
Year: 2014
Venue: UWSpace (University of Waterloo)
PaperDialysis culture in animal cell growth and protein production
Amos, B. · 1995 · University of Birmingham Institutional Research Archive (University of Birmingham)
Full title: Dialysis culture in animal cell growth and protein production
Authors: Amos, B.
Year: 1995
Venue: University of Birmingham Institutional Research Archive (University of Birmingham)
PaperEffect of Culture Conditions on the Glycosylation Pattern of mAb
Aghamohseni, Hengameh · 2015 · UWSpace (University of Waterloo)
Full title: Effect of Culture Conditions on the Glycosylation Pattern of mAb
Authors: Aghamohseni, Hengameh
Year: 2015
Venue: UWSpace (University of Waterloo)
PaperEffect of Different Feeds and Gas Spargers on Monoclonal Antibody Yields in Stirred Tank Reactors
Ouellette, Christina Elizabeth · 2014 · Digital WPI
Full title: Effect of Different Feeds and Gas Spargers on Monoclonal Antibody Yields in Stirred Tank Reactors
Authors: Ouellette, Christina Elizabeth
Year: 2014
Venue: Digital WPI
PaperEffects of Cellular Apoptosis on Productivity of a Mammalian Cell Culture Process
Cote, Shelly A. · 2006 · Digital WPI
Full title: Effects of Cellular Apoptosis on Productivity of a Mammalian Cell Culture Process
Authors: Cote, Shelly A.
Year: 2006
Venue: Digital WPI
PaperEnhancing Production of Recombinant BMP-2 in Mammalian Cell Culture Systems by Inhibition of Pro-protein Cleavage using 9DR Peptides
Zhou, Jing-Jing Aileen · 2008 · Belarusian State Pedagogical University repository (Belarusian State Pedagogical University)
Full title: Enhancing Production of Recombinant BMP-2 in Mammalian Cell Culture Systems by Inhibition of Pro-protein Cleavage using 9DR Peptides
Authors: Zhou, Jing-Jing Aileen
Year: 2008
Venue: Belarusian State Pedagogical University repository (Belarusian State Pedagogical University)
PaperHigh density CHO cell cultures: Improved productivity and product quality
Byrne, Karen M. · 2014
Full title: High density CHO cell cultures: Improved productivity and product quality
Authors: Byrne, Karen M.
Year: 2014
PaperInvestigating into the Dynamics of Mammalian Cell Growth: Using In Vitro to Help Improve Therapies
Brodsky, Arthur Nathan · 2015 · TigerPrints (Clemson University)
Full title: Investigating into the Dynamics of Mammalian Cell Growth: Using In Vitro to Help Improve Therapies
Authors: Brodsky, Arthur Nathan
Year: 2015
Venue: TigerPrints (Clemson University)
PaperInvestigating Low Culture Temperature and Low Media pH of Two Chinese Hamster Ovary (CHO) Cell Lines with Next Generation RNA Sequencing (RNA-Seq) Technology
Lindquist, Timothy James · 2019 · TigerPrints (Clemson University)
Full title: Investigating Low Culture Temperature and Low Media pH of Two Chinese Hamster Ovary (CHO) Cell Lines with Next Generation RNA Sequencing (RNA-Seq) Technology
Authors: Lindquist, Timothy James
Year: 2019
Venue: TigerPrints (Clemson University)
PaperMetabolic Analysis of a CHO Cell Line in Batch and Fed-batch Culture
Naderi, Saeideh · 2011 · UWSpace (University of Waterloo)
Full title: Metabolic Analysis of a CHO Cell Line in Batch and Fed-batch Culture
Authors: Naderi, Saeideh
Year: 2011
Venue: UWSpace (University of Waterloo)
PaperMicroRNA Profiling and Engineering of CHO Cell Lines Stably Expressing Difficult-to-Express Lysosomal Protein
Full title: MicroRNA Profiling and Engineering of CHO Cell Lines Stably Expressing Difficult-to-Express Lysosomal Protein
Authors: Amadi, Ifeanyi
Year: 2019
Venue: Scholarship @ Claremont (The Claremont Colleges)
PapermicroRNAs as potential tools for ‘miR’aculous CHO cell phenotypes in Bioprocessing systems
Solanki, Ankur · 2016
Full title: microRNAs as potential tools for ‘miR’aculous CHO cell phenotypes in Bioprocessing systems
Authors: Solanki, Ankur
Year: 2016
PaperOver Expression of the CMP-sialic Acid Transporter in Chinese Hamster Ovary Cells Leads to Increased Sialylation
Wong, Niki S.C., Yap, Miranda G.S., Wang, Daniel I. C. · 2005 · DSpace@MIT (Massachusetts Institute of Technology)
Full title: Over Expression of the CMP-sialic Acid Transporter in Chinese Hamster Ovary Cells Leads to Increased Sialylation
Authors: Wong, Niki S.C., Yap, Miranda G.S., Wang, Daniel I. C.
Year: 2005
Venue: DSpace@MIT (Massachusetts Institute of Technology)
PaperProfiling the dynamic changes in the phosphoproteome of Chinese hamster ovary cells
Kaushik, Prashant · 2020 · Dublin City University Open Access Institutional Repository (Dublin City University)
Full title: Profiling the dynamic changes in the phosphoproteome of Chinese hamster ovary cells
Authors: Kaushik, Prashant
Year: 2020
Venue: Dublin City University Open Access Institutional Repository (Dublin City University)
PaperProteomic Analysis of Chinese Hamster Ovary Cells Producing Glycosylated Monoclonal Antibodies
Ho, Raymond H. · 2013 · UWSpace (University of Waterloo)
Full title: Proteomic Analysis of Chinese Hamster Ovary Cells Producing Glycosylated Monoclonal Antibodies
Authors: Ho, Raymond H.
Year: 2013
Venue: UWSpace (University of Waterloo)
PaperProteomic profiling of phosphoproteins and secreted proteins from mammalian cell lines in order to gain insights into factors affecting cellular growth and recombinant protein production
Power, Martin · 2015 · Dublin City University Open Access Institutional Repository (Dublin City University)
Full title: Proteomic profiling of phosphoproteins and secreted proteins from mammalian cell lines in order to gain insights into factors affecting cellular growth and recombinant protein production
Authors: Power, Martin
Year: 2015
Venue: Dublin City University Open Access Institutional Repository (Dublin City University)
PaperRéponse biologique de cellules animales à des contraintes hydrodynamiques : simulation numérique, expérimentation et modélisation en bioréacteurs de laboratoire
Barbouche, Naziha · 2008 · Publications Et Travaux Academiques de Lorraine (Universite de Lorraine)
Full title: Réponse biologique de cellules animales à des contraintes hydrodynamiques : simulation numérique, expérimentation et modélisation en bioréacteurs de laboratoire
Authors: Barbouche, Naziha
Year: 2008
Venue: Publications Et Travaux Academiques de Lorraine (Universite de Lorraine)
PaperSingle cell analysis and quantitative modelling of ion concentrations and dielectric properties of Chinese hamster ovary cells
Fazelkhah, Azita · 2020 · Mspace (University of Manitoba)
Full title: Single cell analysis and quantitative modelling of ion concentrations and dielectric properties of Chinese hamster ovary cells
Authors: Fazelkhah, Azita
Year: 2020
Venue: Mspace (University of Manitoba)
PaperSmall scale bioprocess optimization using soft sensors
Maschke, Rüdiger W., John, Gernot T., Pretzner, Barbara, Eibl, Dieter · 2019 · Zürcher Hochschule für Angewandte Wissenschaften digital collection (Zurich University of Applied Sciences)
Full title: Small scale bioprocess optimization using soft sensors
Venue: Zürcher Hochschule für Angewandte Wissenschaften digital collection (Zurich University of Applied Sciences)
PaperSupplementation Strategies for Tuning Glycosylation of Monoclonal Antibodies and Enhancing Growth in Mammalian Cell Culture by Omics Analysis
Blondeel, Eric J. M. · 2018 · UWSpace (University of Waterloo)
Full title: Supplementation Strategies for Tuning Glycosylation of Monoclonal Antibodies and Enhancing Growth in Mammalian Cell Culture by Omics Analysis
Authors: Blondeel, Eric J. M.
Year: 2018
Venue: UWSpace (University of Waterloo)
PaperSystematic Approaches to Identification of Dynamic Flux Balance Models
Nikdel, Ali · 2018 · UWSpace (University of Waterloo)
Full title: Systematic Approaches to Identification of Dynamic Flux Balance Models
Authors: Nikdel, Ali
Year: 2018
Venue: UWSpace (University of Waterloo)
PaperThe co-modulation of apoptosis and the cell cycle
Astley, Kelly · 2010 · University of Birmingham Institutional Research Archive (University of Birmingham)
Full title: The co-modulation of apoptosis and the cell cycle
Authors: Astley, Kelly
Year: 2010
Venue: University of Birmingham Institutional Research Archive (University of Birmingham)
PaperThe Effect of Culture Temperature on Recombinant IFN-γ Production and Quality
Fox, Steven R., Yap, Miranda G.S., Wang, Daniel I. C. · 2004 · DSpace@MIT (Massachusetts Institute of Technology)
Full title: The Effect of Culture Temperature on Recombinant IFN-γ Production and Quality
Authors: Fox, Steven R., Yap, Miranda G.S., Wang, Daniel I. C.
Year: 2004
Venue: DSpace@MIT (Massachusetts Institute of Technology)
PaperThe Effect of Hyper-Osmotic Conditions on the Growth, Metabolism, and Specific Antibody Productivity of a GS-NS0 Cell Line
Brady, Stefanie Ellen · 2009 · University Libraries (University of Maryland)
Full title: The Effect of Hyper-Osmotic Conditions on the Growth, Metabolism, and Specific Antibody Productivity of a GS-NS0 Cell Line
Authors: Brady, Stefanie Ellen
Year: 2009
Venue: University Libraries (University of Maryland)
ThesisImproved bioprocess with CHO-hTSH cells on higher microcarrier concentration provides higher overall biomass and productivity for rhTSH
ThesisDetermination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra
Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn et al. · 2021 · Theses · DOI
Full title: Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra
ThesisManufacture of Recombinant Therapeutic Proteins Using Chinese Hamster Ovary Cells in Large-Scale Bioreactors History, Methods, and Perspectives
Wurm, Florian Maria; de Jesus, Maria · 2025 · Theses · DOI
Full title: Manufacture of Recombinant Therapeutic Proteins Using Chinese Hamster Ovary Cells in Large-Scale Bioreactors History, Methods, and Perspectives
ThesisOverexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells
Berger, Audrey; Le Fourn, Valerie; Masternak, Jacqueline et al. · 2020 · Theses · DOI
Full title: Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells
Authors: Berger, Audrey; Le Fourn, Valerie; Masternak, Jacqueline; Regamey, Alexandre; Bodenmann, Iris; Girod, Pierre-Alain; Mermod, Nicolas
ThesisShaken helical track bioreactors: Providing oxygen to high-density cultures of mammalian cells at volumes up to 1000L by surface aeration with air
Zhang, X.; Stettler, M.; Reif, O. et al. · 2009 · École polytechnique fédérale de Lausanne (EPFL) · DOI
Full title: Shaken helical track bioreactors: Providing oxygen to high-density cultures of mammalian cells at volumes up to 1000L by surface aeration with air
Authors: Zhang, X.; Stettler, M.; Reif, O.; Kocourek, A.; Dejesus, M.; Hacker, D.; Wurm, F.
Year: 2009
Venue: École polytechnique fédérale de Lausanne (EPFL)
ThesisDevelopment of a predictive model for cell growth in shaken bioreactors as a function of the effects of temperature, oxygen transfer rate and seeding cell concentration
Full title: Development of a predictive model for cell growth in shaken bioreactors as a function of the effects of temperature, oxygen transfer rate and seeding cell concentration
ThesisA comparison of orbitally-shaken and stirred-tank bioreactors: pH modulation and bioreactor type affect CHO cell growth and protein glycosylation
Monteil, Dominique T.; Juvet, Valentin; Paz, Jonathan et al. · 2017 · Theses · DOI
Full title: A comparison of orbitally-shaken and stirred-tank bioreactors: pH modulation and bioreactor type affect CHO cell growth and protein glycosylation
Authors: Monteil, Dominique T.; Juvet, Valentin; Paz, Jonathan; Moniatte, Marc; Baldi, Lucia; Hacker, David L.; Wurm, Florian M.
ThesisThe influence of correlated calibration samples on the prediction performance of multivariate models based on mid-infrared spectra of animal cell cultures
Rhiel Martin, H.; Amrhein Michael, I.; Marison Ian, W. et al. · 2006 · Theses · DOI
Full title: The influence of correlated calibration samples on the prediction performance of multivariate models based on mid-infrared spectra of animal cell cultures
ThesisDevelopment and validation of a hybrid model for prediction of viable cell density, titer and cumulative glucose consumption in a mammalian cell culture system
Yatipanthalawa, BS; Wallace Fitzsimons, SE; Horning, T et al. · 2024 · Theses · DOI
Full title: Development and validation of a hybrid model for prediction of viable cell density, titer and cumulative glucose consumption in a mammalian cell culture system
ThesisApplication of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers
Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem et al. · 2019 · Theses · DOI
Full title: Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers
Authors: Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem; Malphettes, Laetitia; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808
ThesisRevealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing
Lee, Jae Seong; Park, Jin Hyoung; Kwang Ha, Tae et al. · 2018 · Theses · DOI
Full title: Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing
Authors: Lee, Jae Seong; Park, Jin Hyoung; Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Samoudi, Mojtaba; Lewis, Nathan E.; Palsson, Bernhard O.; id_orcid 0000-0003-2357-6785; Kildegaard, Helene Faustrup; Min Lee, Gyun
ThesisRNA-seq based expression analysis of the CHO cell protein secretion pathway
Lund, Anne Mathilde; Kaas, Christian Schrøder; Kildegaard, Helene Faustrup et al. · 2013 · Theses · DOI
Full title: RNA-seq based expression analysis of the CHO cell protein secretion pathway
Authors: Lund, Anne Mathilde; Kaas, Christian Schrøder; Kildegaard, Helene Faustrup; Kristensen, Claus; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808
Full title: Impact of cellular stress on recombinant monoclonal antibody produced by high yielding Chinese Hamster Ovary (CHO) cell cultures in bioreactors
ThesisCompartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells
Pérez-Rodriguez, Saumel; Wulff, Tune; Voldborg, Bjørn G et al. · 2021 · Theses · DOI
Full title: Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells
ThesisBaicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity
Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard et al. · 2018 · Theses · DOI
Full title: Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity
Authors: Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Kildegaard, Helene Faustrup; Min Lee, Gyun
ThesisComprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies
Noh, Soo Min; Shin, Seunghyeon; Min Lee, Gyun · 2018 · Theses · DOI
Full title: Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies
Authors: Noh, Soo Min; Shin, Seunghyeon; Min Lee, Gyun
ThesisImproving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup et al. · 2017 · Theses · DOI
Full title: Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
Authors: Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup; Min Lee, Gyun
ThesisApplication of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers
Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem et al. · 2019 · Theses · DOI
Full title: Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers
Authors: Calmels, Cyrielle; Arnoult, Solène; Ben Yahia, Bassem; Malphettes, Laetitia; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808
ThesisRevealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing
Lee, Jae Seong; Park, Jin Hyoung; Kwang Ha, Tae et al. · 2018 · Theses · DOI
Full title: Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing
Authors: Lee, Jae Seong; Park, Jin Hyoung; Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Samoudi, Mojtaba; Lewis, Nathan E.; Palsson, Bernhard O.; id_orcid 0000-0003-2357-6785; Kildegaard, Helene Faustrup; Min Lee, Gyun
ThesisRNA-seq based expression analysis of the CHO cell protein secretion pathway
Lund, Anne Mathilde; Kaas, Christian Schrøder; Kildegaard, Helene Faustrup et al. · 2013 · Theses · DOI
Full title: RNA-seq based expression analysis of the CHO cell protein secretion pathway
Authors: Lund, Anne Mathilde; Kaas, Christian Schrøder; Kildegaard, Helene Faustrup; Kristensen, Claus; Andersen, Mikael Rørdam; id_orcid 0000-0003-4794-6808
Full title: Impact of cellular stress on recombinant monoclonal antibody produced by high yielding Chinese Hamster Ovary (CHO) cell cultures in bioreactors
ThesisCompartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells
Pérez-Rodriguez, Saumel; Wulff, Tune; Voldborg, Bjørn G et al. · 2021 · Theses · DOI
Full title: Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells
ThesisBaicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity
Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard et al. · 2018 · Theses · DOI
Full title: Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity
Authors: Kwang Ha, Tae; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kol, Stefan; Kildegaard, Helene Faustrup; Min Lee, Gyun
ThesisEvaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration
Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Kumar Ganesan, Saravana et al. · 2025 · Theses · DOI
Full title: Evaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration
Authors: Catalán-Tatjer, David; id_orcid 0000-0002-0900-9912; Kumar Ganesan, Saravana; Martínez-Monje, Iván; Grav, Lise M.; id_orcid 0000-0001-8042-7108; Lavado-García, Jesús; Nielsen, Lars K.
ThesisKnockout of sialidase and pro-apoptotic genes in Chinese hamster ovary cells enables the production of recombinant human erythropoietin in fed-batch cultures
Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard et al. · 2020 · Theses · DOI
Full title: Knockout of sialidase and pro-apoptotic genes in Chinese hamster ovary cells enables the production of recombinant human erythropoietin in fed-batch cultures
Authors: Ha, Tae Kwang; id_orcid 0000-0001-7804-0051; Hansen, Anders Holmgaard; id_orcid 0000-0002-6007-4787; Kildegaard, Helene Faustrup; Lee, Gyun Min
ThesisImproving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup et al. · 2017 · Theses · DOI
Full title: Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
Authors: Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup; Min Lee, Gyun
ThesisSystems Glycoengineering: Integrated Analyses of Glycomics, Transcriptomics and Phenotypic Data Reveal Complex Cellular Response to Glycoengineering in CHO Cells
Chiang, Wan-Tien; Gazestani, Vahid H.; Bao, Bokan et al. · 2020 · Theses · DOI
Full title: Systems Glycoengineering: Integrated Analyses of Glycomics, Transcriptomics and Phenotypic Data Reveal Complex Cellular Response to Glycoengineering in CHO Cells
Full title: An Unstructured Kinetic Model of Macromolecular Metabolism in Batch and Fed-batch Cultures of Hybridoma Cells Producing Monoclonal Antibody
ThesisUnderstanding the impact of bioprocess conditions on monoclonal antibody glycosylation in mammalian cell cultures through experimental and computational analyses
Full title: Understanding the impact of bioprocess conditions on monoclonal antibody glycosylation in mammalian cell cultures through experimental and computational analyses
ThesisSynergising stoichiometric modelling with artificial neural networks to predict antibody glycosylation patterns in Chinese hamster ovary cells
Antonakoudis, Athanasios; Strain, Benjamin; Barbosa, Rodrigo et al. · 2021 · Theses · DOI
Full title: Synergising stoichiometric modelling with artificial neural networks to predict antibody glycosylation patterns in Chinese hamster ovary cells
Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra
Full title: Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra
Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production
Full title: Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production
Investigation of the interactions of critical scale-up parameters (pH, pO2 and pCO2) on CHO batch performance and critical quality attributes
Brunner, Matthias, Fricke, Jens, Kröll, Paul, Herwig, Christoph · 2016
Full title: Investigation of the interactions of critical scale-up parameters (pH, pO2 and pCO2) on CHO batch performance and critical quality attributes
Authors: Brunner, Matthias, Fricke, Jens, Kröll, Paul, Herwig, Christoph
Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors
Full title: Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors
Pre-stage perfusion and ultra-high seeding cell density in CHO fed-batch culture: a case study for process intensification guided by systems biotechnology
Full title: Pre-stage perfusion and ultra-high seeding cell density in CHO fed-batch culture: a case study for process intensification guided by systems biotechnology
Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation: applied to an industrial cell culture seed train
Full title: Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation: applied to an industrial cell culture seed train
Authors: Rodríguez, Tanja Hernández, Posch, C., Pörtner, Ralf, Frahm, Björn
Compartment-specific metabolome labeling enables the identification of subcellular fluxes that may serve as promising metabolic engineering targets in CHO cells
Full title: Compartment-specific metabolome labeling enables the identification of subcellular fluxes that may serve as promising metabolic engineering targets in CHO cells
Full title: Enhancement of recombinant human IL-24 (rhIL-24) protein production from site-specific integrated engineered CHO cells by sodium butyrate treatment
Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins
Wolnick, Nicolas, Dickson, Marissa, Webster, Thaddaeus A., Connolly, Roger P., Fernandes, Nancy, Encheva, Vesela, Crittenden, Hunter, Hodgkins, Jessica, Hadley, Brian C., Palermo, Gabriella, Hendrick, Shannon, Newell, Roy A., Gray, Genevieve, Siltanen, Christian, Armstrong, Julia, Downey, Brandon, Mason, Carrie · 2024
Full title: Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins
Authors: Wolnick, Nicolas, Dickson, Marissa, Webster, Thaddaeus A., Connolly, Roger P., Fernandes, Nancy, Encheva, Vesela, Crittenden, Hunter, Hodgkins, Jessica, Hadley, Brian C., Palermo, Gabriella, Hendrick, Shannon, Newell, Roy A., Gray, Genevieve, Siltanen, Christian, Armstrong, Julia, Downey, Brandon, Mason, Carrie
Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
López-Meza, Julián, Araíz-Hernández, Diana, Carrillo‐Cocom, Leydi Maribel, López‐Pacheco, Felipe, Rocha-Pizaña, María del Refugio, Álvarez, Mario Moisés · 2015
Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
Authors: López-Meza, Julián, Araíz-Hernández, Diana, Carrillo‐Cocom, Leydi Maribel, López‐Pacheco, Felipe, Rocha-Pizaña, María del Refugio, Álvarez, Mario Moisés
The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells
Weihua Tian, Zilu Ye, Shengjun Wang, M. A. Schulz, Julie Van Coillie, Lingbo Sun, Yen-Hsi Chen, Yoshiki Narimatsu, L. Hansen, C. Kristensen, U. Mandel, E. Bennett, S. Jabbarzadeh-Tabrizi, R. Schiffmann, Jinsong Shen, S. Vakhrushev, H. Clausen, Zhang Yang · 2019
Full title: The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells
Authors: Weihua Tian, Zilu Ye, Shengjun Wang, M. A. Schulz, Julie Van Coillie, Lingbo Sun, Yen-Hsi Chen, Yoshiki Narimatsu, L. Hansen, C. Kristensen, U. Mandel, E. Bennett, S. Jabbarzadeh-Tabrizi, R. Schiffmann, Jinsong Shen, S. Vakhrushev, H. Clausen, Zhang Yang
Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
Gutierrez, Jahir M., Feizi, Amir, Li, Shangzhong, Kallehauge, Thomas Beuchert, Hefzi, Hooman, Grav, Lise Marie, Ley, Daniel, Hızal, Deniz Baycın, Betenbaugh, Michael J., Voldborg, Björn G., Kildegaard, Helene Faustrup, Lee, Gyun Min, Palsson, Bernhard Ø., Nielsen, Jens, Lewis, Nathan E. · 2020
Full title: Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
Authors: Gutierrez, Jahir M., Feizi, Amir, Li, Shangzhong, Kallehauge, Thomas Beuchert, Hefzi, Hooman, Grav, Lise Marie, Ley, Daniel, Hızal, Deniz Baycın, Betenbaugh, Michael J., Voldborg, Björn G., Kildegaard, Helene Faustrup, Lee, Gyun Min, Palsson, Bernhard Ø., Nielsen, Jens, Lewis, Nathan E.
Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation and ER stress in CHO cells
Sinharoy, Pritam, Aziz, Aaron H., Majewska, Natalia I., Ahuja, Sanjeev, Handlogten, Michael W. · 2020
Full title: Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation and ER stress in CHO cells
Authors: Sinharoy, Pritam, Aziz, Aaron H., Majewska, Natalia I., Ahuja, Sanjeev, Handlogten, Michael W.
Cai, Cindy X., Doria‐Rose, Nicole A., Schneck, Nicole A., Ivleva, Vera B., Tippett, Brad, Shadrick, William R., O’Connell, Sarah, Cooper, Jonathan W., Schneiderman, Zachary, Zhang, Baoshan, Gowetski, Daniel B., Blackstock, Daniel, Demirji, Jacob, Lin, Bob C., Gorman, Jason, Liu, Tracy, Li, Yile, McDermott, Adrian B., Kwong, Peter D., Carlton, Kevin, Gall, Jason G., Lei, Q. Paula · 2022
Full title: Tyrosine O-sulfation proteoforms affect HIV-1 monoclonal antibody potency
Authors: Cai, Cindy X., Doria‐Rose, Nicole A., Schneck, Nicole A., Ivleva, Vera B., Tippett, Brad, Shadrick, William R., O’Connell, Sarah, Cooper, Jonathan W., Schneiderman, Zachary, Zhang, Baoshan, Gowetski, Daniel B., Blackstock, Daniel, Demirji, Jacob, Lin, Bob C., Gorman, Jason, Liu, Tracy, Li, Yile, McDermott, Adrian B., Kwong, Peter D., Carlton, Kevin, Gall, Jason G., Lei, Q. Paula
Microevolutionary dynamics of eccDNA in Chinese hamster ovary cells grown in fed-batch cultures under control and lactate-stressed conditions
Chitwood, Dylan G., Wang, Qinghua, Klaubert, Stephanie R., Green, Kiana, Wu, Cathy, Harcum, Sarah W., Saski, Christopher · 2023
Full title: Microevolutionary dynamics of eccDNA in Chinese hamster ovary cells grown in fed-batch cultures under control and lactate-stressed conditions
Authors: Chitwood, Dylan G., Wang, Qinghua, Klaubert, Stephanie R., Green, Kiana, Wu, Cathy, Harcum, Sarah W., Saski, Christopher
Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing
Williams, Thomas J., Kalinka, Kevin, Sanches, Rui, Blanchard-Emmerson, Greg, Watts, Samuel, Davies, Lee, Knevelman, Carol, McCloskey, Laura J., Jones, Peter B., Mitrophanous, Kyriacos, Miskin, James, Dikicioǧlu, Duygu · 2023
Full title: Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing
Authors: Williams, Thomas J., Kalinka, Kevin, Sanches, Rui, Blanchard-Emmerson, Greg, Watts, Samuel, Davies, Lee, Knevelman, Carol, McCloskey, Laura J., Jones, Peter B., Mitrophanous, Kyriacos, Miskin, James, Dikicioǧlu, Duygu
Modifying the glycosylation profile of SARS-CoV-2 spike-based subunit vaccines alters focusing of the humoral immune response in a mouse model
Tyler M Renner, M. Stuible, M. Rossotti, Nazanin Rohani, Yuneivy Cepero-Donates, Janelle Sauvageau, L. Deschatelets, R. Dudani, Blair A. Harrison, Jason Baardsnes, Izel Koyuturk, F. St. Michael, Jennifer J Hill, U. Hemraz, A. Lenferink, J. Tanha, Bárbara Fernandes, António Roldão, M. McCluskie, Bassel Akache, Yves Durocher · 2025
Full title: Modifying the glycosylation profile of SARS-CoV-2 spike-based subunit vaccines alters focusing of the humoral immune response in a mouse model
Authors: Tyler M Renner, M. Stuible, M. Rossotti, Nazanin Rohani, Yuneivy Cepero-Donates, Janelle Sauvageau, L. Deschatelets, R. Dudani, Blair A. Harrison, Jason Baardsnes, Izel Koyuturk, F. St. Michael, Jennifer J Hill, U. Hemraz, A. Lenferink, J. Tanha, Bárbara Fernandes, António Roldão, M. McCluskie, Bassel Akache, Yves Durocher
Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion
Kallehauge, Thomas Beuchert, Li, Shangzhong, Pedersen, Lasse Ebdrup, Ha, Tae Kwang, Ley, Daniel, Andersen, Mikael Rørdam, Kildegaard, Helene Faustrup, Lee, Gyun Min, Lewis, Nathan E. · 2017
Full title: Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion
Authors: Kallehauge, Thomas Beuchert, Li, Shangzhong, Pedersen, Lasse Ebdrup, Ha, Tae Kwang, Ley, Daniel, Andersen, Mikael Rørdam, Kildegaard, Helene Faustrup, Lee, Gyun Min, Lewis, Nathan E.
<i>N</i>-Glycosylation profiling of intact target proteins by high-resolution mass spectrometry (MS) and glycan analysis using ion mobility-MS/MS
Quaranta, Alessandro, Spasova, Maya, Passarini, Elena, Karlsson, Isabella, Ndreu, Lorena, Thorsén, Gunnar, Ilag, Leopold L. · 2019
Full title: <i>N</i>-Glycosylation profiling of intact target proteins by high-resolution mass spectrometry (MS) and glycan analysis using ion mobility-MS/MS
Authors: Quaranta, Alessandro, Spasova, Maya, Passarini, Elena, Karlsson, Isabella, Ndreu, Lorena, Thorsén, Gunnar, Ilag, Leopold L.
Glycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster ovary fed-batch cultures
Hutter, Sandro, Villiger, Thomas K., Brühlmann, David, Stettler, Matthieu, Broly, Hervé, Šoóš, Miroslav, Gunawan, Rudiyanto · 2017
Full title: Glycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster ovary fed-batch cultures
Authors: Hutter, Sandro, Villiger, Thomas K., Brühlmann, David, Stettler, Matthieu, Broly, Hervé, Šoóš, Miroslav, Gunawan, Rudiyanto
A recombinant gp145 Env glycoprotein from HIV-1 expressed in two different cell lines: effects on glycosylation and antigenicity
González‐Feliciano, José A., Akamine, Pearl, Capó-Vélez, Coral M., Delgado‐Vélez, Manuel, Dussupt, Vincent, Krebs, Shelly J., Wojna, Valerie, Polonis, Victoria R., Baerga‐Ortiz, Abel, Lasalde‐Dominicci, José A. · 2020
Full title: A recombinant gp145 Env glycoprotein from HIV-1 expressed in two different cell lines: effects on glycosylation and antigenicity
Authors: González‐Feliciano, José A., Akamine, Pearl, Capó-Vélez, Coral M., Delgado‐Vélez, Manuel, Dussupt, Vincent, Krebs, Shelly J., Wojna, Valerie, Polonis, Victoria R., Baerga‐Ortiz, Abel, Lasalde‐Dominicci, José A.
Production of Trimeric SARS-CoV-2 Spike Protein by CHO Cells for Serological COVID-19 Testing
Johari, Yusuf B., Jaffe, Stephen, Scarrott, Joseph M., Johnson, Abayomi O., Mozzanino, Théo, Pohle, Thilo H., Maisuria, Sheetal, Bhayat‐Cammack, Amina, Brown, Adam, Tee, Kang Lan, Jackson, Philip J., Wong, Tuck Seng, Dickman, Mark J., Sargur, Ravishankar, James, David C. · 2020
Full title: Production of Trimeric SARS-CoV-2 Spike Protein by CHO Cells for Serological COVID-19 Testing
Authors: Johari, Yusuf B., Jaffe, Stephen, Scarrott, Joseph M., Johnson, Abayomi O., Mozzanino, Théo, Pohle, Thilo H., Maisuria, Sheetal, Bhayat‐Cammack, Amina, Brown, Adam, Tee, Kang Lan, Jackson, Philip J., Wong, Tuck Seng, Dickman, Mark J., Sargur, Ravishankar, James, David C.
Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening
Kim, Su Hyun, Shin, Seunghyeon, Baek, Minhye, Xiong, Kai, Karottki, Karen Julie la Cour, Hefzi, Hooman, Grav, Lise Marie, Pedersen, Lasse Ebdrup, Kildegaard, Helene Faustrup, Lewis, Nathan E., Lee, Jae Seong, Lee, Gyun Min · 2022
Full title: Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening
Authors: Kim, Su Hyun, Shin, Seunghyeon, Baek, Minhye, Xiong, Kai, Karottki, Karen Julie la Cour, Hefzi, Hooman, Grav, Lise Marie, Pedersen, Lasse Ebdrup, Kildegaard, Helene Faustrup, Lewis, Nathan E., Lee, Jae Seong, Lee, Gyun Min
Temporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch and Perfusion Bioreactor Operation
Gyorgypal, Aron, Fratz‐Berilla, Erica J., Kohnhorst, Casey, Powers, David N., Chundawat, Shishir P. S. · 2023
Full title: Temporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch and Perfusion Bioreactor Operation
Authors: Gyorgypal, Aron, Fratz‐Berilla, Erica J., Kohnhorst, Casey, Powers, David N., Chundawat, Shishir P. S.
Choice of host cell line is essential for the functional glycosylation of the fragment crystallizable (Fc) region of human IgG1 inhibitors of influenza B viruses
P. Blundell, Dongli Lu, A. Dell, S. Haslam, R. Pleass · 2019
Full title: Choice of host cell line is essential for the functional glycosylation of the fragment crystallizable (Fc) region of human IgG1 inhibitors of influenza B viruses
Authors: P. Blundell, Dongli Lu, A. Dell, S. Haslam, R. Pleass
Visualization of the HIV-1 Env Glycan Shield Across Scales
Berndsen, Zachary T., Chakraborty, Srirupa, Wang, Xiaoning, Cottrell, Christopher A., Torres, Jonathan L., Diedrich, Jolene K., López, César A., Yates, John R., Gils, Marit J. van, Paulson, James C., Gnanakaran, S., Ward, Andrew B. · 2019
Full title: Visualization of the HIV-1 Env Glycan Shield Across Scales
Authors: Berndsen, Zachary T., Chakraborty, Srirupa, Wang, Xiaoning, Cottrell, Christopher A., Torres, Jonathan L., Diedrich, Jolene K., López, César A., Yates, John R., Gils, Marit J. van, Paulson, James C., Gnanakaran, S., Ward, Andrew B.
Influência do butirato de sódio, da cicloheximida e do cloreto de manganês na produtividade, glicosilação e propriedades biológicas da tireotrofina humana derivada de CHO
Damiani, Renata · 2014
Full title: Influência do butirato de sódio, da cicloheximida e do cloreto de manganês na produtividade, glicosilação e propriedades biológicas da tireotrofina humana derivada de CHO
Synergizing metabolic flux analysis and nucleotide sugar metabolism to understand the control of glycosylation of recombinant protein in CHO cells
Burleigh, Susan C, Laar, Teun van de, Stroop, Corné J.M., Grunsven, Wout MJ van, O’Donoghue, Niaobh, Rudd, Pauline M., Davey, Gavin P. · 2011
Full title: Synergizing metabolic flux analysis and nucleotide sugar metabolism to understand the control of glycosylation of recombinant protein in CHO cells
Authors: Burleigh, Susan C, Laar, Teun van de, Stroop, Corné J.M., Grunsven, Wout MJ van, O’Donoghue, Niaobh, Rudd, Pauline M., Davey, Gavin P.
Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells
Sumitomo, Yasuhiko, Higashitsuji, Hiroaki, Higashitsuji, Hisako, Liu, Yu, Fujita, Takanori, Sakurai, Toshiharu, Candeias, Marco M., Itoh, Katsuhiko, Chiba, Tsutomu, Fujita, Jun · 2012
Full title: Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells
Authors: Sumitomo, Yasuhiko, Higashitsuji, Hiroaki, Higashitsuji, Hisako, Liu, Yu, Fujita, Takanori, Sakurai, Toshiharu, Candeias, Marco M., Itoh, Katsuhiko, Chiba, Tsutomu, Fujita, Jun
Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC
Full title: Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC
Cell functional enviromics: Unravelling the function of environmental factors
Teixeira, Ana P., Dias, João M.L., Carinhas, Nuno, Sousa, Marcos F. Q., Clemente, João J., Cunha, António E., Stosch, Moritz von, Alves, Paula M., Carrondo, Manuel J.T., Oliveira, Rui · 2011
Full title: Cell functional enviromics: Unravelling the function of environmental factors
Authors: Teixeira, Ana P., Dias, João M.L., Carinhas, Nuno, Sousa, Marcos F. Q., Clemente, João J., Cunha, António E., Stosch, Moritz von, Alves, Paula M., Carrondo, Manuel J.T., Oliveira, Rui
Non-stationary 13C metabolic flux analysis of Chinese hamster ovary cells in batch culture using extracellular labeling highlights metabolic reversibility and compartmentation
Full title: Non-stationary 13C metabolic flux analysis of Chinese hamster ovary cells in batch culture using extracellular labeling highlights metabolic reversibility and compartmentation
Single use bioreactors for the clinical production of monoclonal antibodies – a study to analyze the performance of a CHO cell line and the quality of the produced monoclonal antibody
Full title: Single use bioreactors for the clinical production of monoclonal antibodies – a study to analyze the performance of a CHO cell line and the quality of the produced monoclonal antibody
Characterization of metalloprotease and serine protease activities in batch CHO cell cultures: control of human recombinant IFN-γ proteolysis by addition of iron citrate
Full title: Characterization of metalloprotease and serine protease activities in batch CHO cell cultures: control of human recombinant IFN-γ proteolysis by addition of iron citrate
Analysis of glycolytic flux as a rapid screen to identify low lactate producing CHO cell lines with desirable monoclonal antibody yield and glycan profile
R. Legmann, Julie Melito, I. Belzer, D. Ferrick · 2011
Full title: Analysis of glycolytic flux as a rapid screen to identify low lactate producing CHO cell lines with desirable monoclonal antibody yield and glycan profile
Authors: R. Legmann, Julie Melito, I. Belzer, D. Ferrick
Protein folding and glycosylation process are influenced by mild hypothermia in batch culture and by specific growth rate in continuous cultures of CHO cells producing rht-PA
M. Vergara, S. Becerra, J. Berrios, J. Reyes, C. Acevedo, R. Gonzalez, N. Osses, C. Altamirano · 2013
Full title: Protein folding and glycosylation process are influenced by mild hypothermia in batch culture and by specific growth rate in continuous cultures of CHO cells producing rht-PA
Authors: M. Vergara, S. Becerra, J. Berrios, J. Reyes, C. Acevedo, R. Gonzalez, N. Osses, C. Altamirano
Understanding the impact of different bioprocess conditions on monoclonal antibody glycosylation in CHO cell cultures through experimental and computational analyses
Sou, Si Nga, Sellick, Christopher, Lee, Ken, Mason, Alison, Kyriakopoulos, Sarantos, Polizzi, Karen M., Kontoravdi, Cleo · 2015
Full title: Understanding the impact of different bioprocess conditions on monoclonal antibody glycosylation in CHO cell cultures through experimental and computational analyses
Authors: Sou, Si Nga, Sellick, Christopher, Lee, Ken, Mason, Alison, Kyriakopoulos, Sarantos, Polizzi, Karen M., Kontoravdi, Cleo
ambr™ Mini-bioreactor as a high-throughput tool for culture process development to accelerate transfer to stainless steel manufacturing scale: comparability study from process performance to product quality attributes
Frédéric Delouvroy, Gaetan Siriez, A. Tran, Larissa Mukankurayija, N. Kochanowski, Laetitia Malphettes · 2015
Full title: ambr™ Mini-bioreactor as a high-throughput tool for culture process development to accelerate transfer to stainless steel manufacturing scale: comparability study from process performance to product quality attributes
Authors: Frédéric Delouvroy, Gaetan Siriez, A. Tran, Larissa Mukankurayija, N. Kochanowski, Laetitia Malphettes
Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cells grown in fed-batch cultures
Chitwood, Dylan G., Wang, Qinghua, Elliott, Kathryn, Bullock, Aiyana, Jordana, Dwon, Li, Zhigang, Wu, Cathy, Harcum, Sarah W., Saski, Christopher · 2021
Full title: Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cells grown in fed-batch cultures
Authors: Chitwood, Dylan G., Wang, Qinghua, Elliott, Kathryn, Bullock, Aiyana, Jordana, Dwon, Li, Zhigang, Wu, Cathy, Harcum, Sarah W., Saski, Christopher
Roles of N-linked and O-linked glycosylation sites in the activity of equine chorionic gonadotropin in cells expressing rat luteinizing hormone/chorionic gonadotropin receptor and follicle-stimulating hormone receptor
Full title: Roles of N-linked and O-linked glycosylation sites in the activity of equine chorionic gonadotropin in cells expressing rat luteinizing hormone/chorionic gonadotropin receptor and follicle-stimulating hormone receptor
Abstracts from the 26th European Society for Animal Cell Technology Meeting - Cell culture technologies: bridging academia and industry to provide solutions for patients
Full title: Abstracts from the 26th European Society for Animal Cell Technology Meeting - Cell culture technologies: bridging academia and industry to provide solutions for patients
Responses of CHO-DHFR cells to ratio of asparagine to glutamine in feed media: cell growth, antibody production, metabolic waste, glutamate, and energy metabolism
Full title: Responses of CHO-DHFR cells to ratio of asparagine to glutamine in feed media: cell growth, antibody production, metabolic waste, glutamate, and energy metabolism
Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process
Morris, Caitlin, Polanco, Ashli, Yongky, Andrew, Xu, Jianlin, Huang, Zhuangrong, Zhao, Jia, McFarland, Kevin S., Park, Seo‐Young, Warrack, Bethanne M., Reily, Michael D., Borys, Michael, Li, Zheng Jian, Yoon, Seongkyu · 2020
Full title: Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process
Authors: Morris, Caitlin, Polanco, Ashli, Yongky, Andrew, Xu, Jianlin, Huang, Zhuangrong, Zhao, Jia, McFarland, Kevin S., Park, Seo‐Young, Warrack, Bethanne M., Reily, Michael D., Borys, Michael, Li, Zheng Jian, Yoon, Seongkyu
Seed train process intensification strategy offers potential for rapid, cost-effective scale-up of biosimilars manufacturing
Rajib Malla, D. Shah, Chinmay N Gajendragadkar, Vijayalakshmi Vamanan, Deepak Singh, Suraj Gupta, Deepak Vengovan, Ravi Trivedi, H. Weichert, Melisa Carpio, K. Chandran · 2021
Full title: Seed train process intensification strategy offers potential for rapid, cost-effective scale-up of biosimilars manufacturing
Authors: Rajib Malla, D. Shah, Chinmay N Gajendragadkar, Vijayalakshmi Vamanan, Deepak Singh, Suraj Gupta, Deepak Vengovan, Ravi Trivedi, H. Weichert, Melisa Carpio, K. Chandran
Specific Biological Activity of Equine Chorionic Gonadotropin (eCG) Glycosylation Sites in Cells Expressing Equine Luteinizing Hormone/CG (eLH/CG) Receptor
Byambaragchaa, Munkhzaya, Choi, Seung-Hee, Joo, Hyo-Eun, Kim, Sang-Gwon, Kim, Yean-Ji, Park, Gyeong-Eun, Kang, Myung-Hwa, Min, Kwan-Sik · 2021
Full title: Specific Biological Activity of Equine Chorionic Gonadotropin (eCG) Glycosylation Sites in Cells Expressing Equine Luteinizing Hormone/CG (eLH/CG) Receptor
Authors: Byambaragchaa, Munkhzaya, Choi, Seung-Hee, Joo, Hyo-Eun, Kim, Sang-Gwon, Kim, Yean-Ji, Park, Gyeong-Eun, Kang, Myung-Hwa, Min, Kwan-Sik
Endoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat Cultures
Full title: Endoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat Cultures
Effect of Temperature Downshift on the Transcriptomic Responses of Chinese Hamster Ovary Cells Using Recombinant Human Tissue Plasminogen Activator Production Culture
Full title: Effect of Temperature Downshift on the Transcriptomic Responses of Chinese Hamster Ovary Cells Using Recombinant Human Tissue Plasminogen Activator Production Culture
Understanding and Controlling Sialylation in a CHO Fc-Fusion Process
Lewis, Amanda M., Croughan, William D., Aranı́bar, Nelly, Lee, Alison G., Warrack, Bethanne M., Abu‐Absi, Nicholas R., Patel, Rutva, Drew, Barry, Borys, Michael, Reily, Michael D., Li, Zheng Jian · 2016
Full title: Understanding and Controlling Sialylation in a CHO Fc-Fusion Process
Authors: Lewis, Amanda M., Croughan, William D., Aranı́bar, Nelly, Lee, Alison G., Warrack, Bethanne M., Abu‐Absi, Nicholas R., Patel, Rutva, Drew, Barry, Borys, Michael, Reily, Michael D., Li, Zheng Jian
Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production
O’Rourke, Sara M., Byrne, Gabriel, Tatsuno, Gwen P., Wright, Meredith, Yu, Bin, Mesa, Kathryn A., Doran, Rachel C., Alexander, David L., Berman, Phillip W. · 2018
Full title: Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production
Authors: O’Rourke, Sara M., Byrne, Gabriel, Tatsuno, Gwen P., Wright, Meredith, Yu, Bin, Mesa, Kathryn A., Doran, Rachel C., Alexander, David L., Berman, Phillip W.
Full title: High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells
A recombinant gp145 Env glycoprotein from HIV-1 expressed in two different cell lines: Effects on glycosylation and antigenicity
González‐Feliciano, José A., Akamine, Pearl, Capó-Vélez, Coral M., Delgado‐Vélez, Manuel, Dussupt, Vincent, Krebs, Shelly J., Wojna, Valerie, Polonis, Victoria R., Baerga‐Ortiz, Abel, Lasalde‐Dominicci, José A. · 2020
Full title: A recombinant gp145 Env glycoprotein from HIV-1 expressed in two different cell lines: Effects on glycosylation and antigenicity
Authors: González‐Feliciano, José A., Akamine, Pearl, Capó-Vélez, Coral M., Delgado‐Vélez, Manuel, Dussupt, Vincent, Krebs, Shelly J., Wojna, Valerie, Polonis, Victoria R., Baerga‐Ortiz, Abel, Lasalde‐Dominicci, José A.
Gene editing in CHO cells to prevent proteolysis and enhance glycosylation: Production of HIV envelope proteins as vaccine immunogens
Li, Sophia W., Wright, Meredith, Healey, John F., Hutchinson, Jennie M., O’Rourke, Sara M., Mesa, Kathryn A., Lollar, Pete, Berman, Phillip W. · 2020
Full title: Gene editing in CHO cells to prevent proteolysis and enhance glycosylation: Production of HIV envelope proteins as vaccine immunogens
Authors: Li, Sophia W., Wright, Meredith, Healey, John F., Hutchinson, Jennie M., O’Rourke, Sara M., Mesa, Kathryn A., Lollar, Pete, Berman, Phillip W.
Evidence for co-translational misincorporation of non-canonical amino acid hydroxyproline in recombinant antibodies produced in Chinese Hamster Ovary (CHO) cell lines
Boddapati, Shanta, Gilmore, Jason M., Boone, Kyle, Bushey, John, Ross, Jonathan, Gfeller, Brian, McFee, William A., Rao, Romesh, Corrigan, Greg, Chen, Aaron, Clarke, Howard R. G., Valliere‐Douglass, John, Bhargava, Swapnil · 2020
Full title: Evidence for co-translational misincorporation of non-canonical amino acid hydroxyproline in recombinant antibodies produced in Chinese Hamster Ovary (CHO) cell lines
Authors: Boddapati, Shanta, Gilmore, Jason M., Boone, Kyle, Bushey, John, Ross, Jonathan, Gfeller, Brian, McFee, William A., Rao, Romesh, Corrigan, Greg, Chen, Aaron, Clarke, Howard R. G., Valliere‐Douglass, John, Bhargava, Swapnil
Full title: Deciphering Metabolic Pathways in High Seeding Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective
Full title: Ouantitative Proteomic Analysis of Cellular Responses to a Designed Amino Acid Feed in a Monoclonal Antibody Producing Chinese Hamster Ovary Cell Line
Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Productivity and Product Quality.
Strasser, Lisa, Farrell, Amy, Ho, Jenny T C, Scheffler, Kai, Cook, Ken, Pankert, Patrick, Mowlds, Peter, Viner, Rosa, Karger, Barry L, Bones, Jonathan · 2021
Full title: Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Productivity and Product Quality.
Authors: Strasser, Lisa, Farrell, Amy, Ho, Jenny T C, Scheffler, Kai, Cook, Ken, Pankert, Patrick, Mowlds, Peter, Viner, Rosa, Karger, Barry L, Bones, Jonathan
Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments
Bayer, Benjamin, Duerkop, Mark, Striedner, Gerald, Sissolak, Bernhard · 2021
Full title: Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments
Authors: Bayer, Benjamin, Duerkop, Mark, Striedner, Gerald, Sissolak, Bernhard
Full title: Boost dynamic protocols for producing mammalian biopharmaceuticals with intensified DoE—a practical guide to analyses with OLS and hybrid modeling
A Linkage-specific Sialic Acid Labeling Strategy Reveals Different Site-specific Glycosylation Patterns in SARS-CoV-2 Spike Protein Produced in CHO and HEK Cell Substrates
Wang, Qiong, Wang, Yan, Yang, Shuang, Lin, Chang-Yi, Aliyu, Lateef, Chen, Yiqun, Parsons, Lisa M., Tian, Yuan, Jia, Hongpeng, Pekosz, Andrew, Betenbaugh, Michael J., Cipollo, John F. · 2021
Full title: A Linkage-specific Sialic Acid Labeling Strategy Reveals Different Site-specific Glycosylation Patterns in SARS-CoV-2 Spike Protein Produced in CHO and HEK Cell Substrates
Authors: Wang, Qiong, Wang, Yan, Yang, Shuang, Lin, Chang-Yi, Aliyu, Lateef, Chen, Yiqun, Parsons, Lisa M., Tian, Yuan, Jia, Hongpeng, Pekosz, Andrew, Betenbaugh, Michael J., Cipollo, John F.
Full title: Deciphering Metabolic Pathways in High-Seeding-Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective
High-Level Production of scFv-Fc Antibody Using an Artificial Promoter System with Transcriptional Positive Feedback Loop of Transactivator in CHO Cells
Full title: High-Level Production of scFv-Fc Antibody Using an Artificial Promoter System with Transcriptional Positive Feedback Loop of Transactivator in CHO Cells
Dynamics of Amino Acid Metabolism, Gene Expression, and Circulomics in a Recombinant Chinese Hamster Ovary Cell Line Adapted to Moderate and High Levels of Extracellular Lactate
Chitwood, Dylan G., Uy, Lisa, Fu, Wanfang, Klaubert, Stephanie R., Harcum, Sarah W., Saski, Christopher · 2023
Full title: Dynamics of Amino Acid Metabolism, Gene Expression, and Circulomics in a Recombinant Chinese Hamster Ovary Cell Line Adapted to Moderate and High Levels of Extracellular Lactate
Authors: Chitwood, Dylan G., Uy, Lisa, Fu, Wanfang, Klaubert, Stephanie R., Harcum, Sarah W., Saski, Christopher
Hyperosmolarity Triggers the Warburg Effect in Chinese Hamster Ovary Cells and Reveals a Reduced Mitochondria Horsepower
Moreira, Jorgelindo da Veiga, Staercke, Lenny De, Martínez-Basilio, Pablo César, Gauthier-Thibodeau, Sandrine, Montégut, Léa, Schwartz, Laurent, Jolicœur, Mario · 2021
Full title: Hyperosmolarity Triggers the Warburg Effect in Chinese Hamster Ovary Cells and Reveals a Reduced Mitochondria Horsepower
Authors: Moreira, Jorgelindo da Veiga, Staercke, Lenny De, Martínez-Basilio, Pablo César, Gauthier-Thibodeau, Sandrine, Montégut, Léa, Schwartz, Laurent, Jolicœur, Mario
Full title: Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design
Authors: Rodríguez, Tanja Hernández, Sekulic, Anton, Lange‐Hegermann, Markus, Frahm, Björn
Identification of Cell Culture Factors Influencing Afucosylation Levels in Monoclonal Antibodies by Partial Least-Squares Regression and Variable Importance Metrics
Rish, Adam J., Huang, Zhuangrong, Siddiquee, Khandaker, Xu, Jianlin, Anderson, Carl A., Borys, Michael, Khetan, Anurag · 2023
Full title: Identification of Cell Culture Factors Influencing Afucosylation Levels in Monoclonal Antibodies by Partial Least-Squares Regression and Variable Importance Metrics
Authors: Rish, Adam J., Huang, Zhuangrong, Siddiquee, Khandaker, Xu, Jianlin, Anderson, Carl A., Borys, Michael, Khetan, Anurag
An Investigation into the Metabolic Differences between Conventional and High Seeding Density Fed-Batch Cell Cultures by Applying a Segmented Modeling Approach
Full title: An Investigation into the Metabolic Differences between Conventional and High Seeding Density Fed-Batch Cell Cultures by Applying a Segmented Modeling Approach
Authors: Teresa Laura Krumm, Alireza Ehsani, Jochen Schaub, Fabian Stiefel
Full title: Effect of Sialic Acid on Mammalian Cell Culture and Protein Expression: A Potential Productivity Enhancer for Biopharmaceutical Cell Culture Processes
Off-Gas-Based Soft Sensor for Real-Time Monitoring of Biomass and Metabolism in Chinese Hamster Ovary Cell Continuous Processes in Single-Use Bioreactors
Wallocha, Tobias, Popp, Oliver · 2021
Full title: Off-Gas-Based Soft Sensor for Real-Time Monitoring of Biomass and Metabolism in Chinese Hamster Ovary Cell Continuous Processes in Single-Use Bioreactors
Optimizing the Production of gp145, an HIV-1 Envelope Glycoprotein Vaccine Candidate and Its Encapsulation in Guanosine Microparticles
Akamine, Pearl, González‐Feliciano, José A., Almodóvar, Ruth, Morell, Gloriner, Sandoval, Javier, Capó-Vélez, Coral M., Delgado‐Vélez, Manuel, Prieto-Costas, Luis A., Madera, Bismark, Eichinger, Daniel, Pino, Ignacio, Rivera, José H., Ortiz-Ubarri, José, Rivera, José M., Baerga‐Ortiz, Abel, Lasalde‐Dominicci, José A. · 2023
Full title: Optimizing the Production of gp145, an HIV-1 Envelope Glycoprotein Vaccine Candidate and Its Encapsulation in Guanosine Microparticles
Authors: Akamine, Pearl, González‐Feliciano, José A., Almodóvar, Ruth, Morell, Gloriner, Sandoval, Javier, Capó-Vélez, Coral M., Delgado‐Vélez, Manuel, Prieto-Costas, Luis A., Madera, Bismark, Eichinger, Daniel, Pino, Ignacio, Rivera, José H., Ortiz-Ubarri, José, Rivera, José M., Baerga‐Ortiz, Abel, Lasalde‐Dominicci, José A.
Clustering and curation of electropherograms: an efficient method for analyzing large cohorts of capillary electrophoresis glycomic profiles for bioprocessing operations
Walsh, Ian, Choo, Matthew S., Chiin, Sim Lyn, Mak, Amelia, Tay, Shi Jie, Rudd, Pauline M., Yuansheng, Yang, Choo, Andre, Ho, Ying Swan, Nguyen‐Khuong, Terry · 2020
Full title: Clustering and curation of electropherograms: an efficient method for analyzing large cohorts of capillary electrophoresis glycomic profiles for bioprocessing operations
Authors: Walsh, Ian, Choo, Matthew S., Chiin, Sim Lyn, Mak, Amelia, Tay, Shi Jie, Rudd, Pauline M., Yuansheng, Yang, Choo, Andre, Ho, Ying Swan, Nguyen‐Khuong, Terry
Influência do butirato de sódio, da cicloheximida e do cloreto de manganês na produtividade, glicosilação e propriedades biológicas da tireotrofina humana derivada de CHO
Ribela, Maria Teresa de Carvalho Pinto · 2014
Full title: Influência do butirato de sódio, da cicloheximida e do cloreto de manganês na produtividade, glicosilação e propriedades biológicas da tireotrofina humana derivada de CHO
Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra
Jarusintanakorn, Salinthip; Phechkrajang, Chutima; Khongkaew, Putthiporn et al. · 2021
Full title: Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra
Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe et al. · 2016
Full title: Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
Authors: López-Meza, Julián; Araíz-Hernández, Diana; López-Pacheco, Felipe; Carrillo-Cocom, Leydi Maribel; Rocha-Pizaña, María del Refugio; Alvarez, Mario Moises
**Authors:** Kiat, Tan Hong; Yap, Miranda G.S.; Wang, Daniel I.C. **Institution:** Massachusetts Institute of Technology (MIT) **Date:** 2004-12-15T19:16:30Z
Kiat, Tan Hong; Yap, Miranda G.S.; Wang, Daniel I.C. · 2004
Full title: **Authors:** Kiat, Tan Hong; Yap, Miranda G.S.; Wang, Daniel I.C. **Institution:** Massachusetts Institute of Technology (MIT) **Date:** 2004-12-15T19:16:30Z
Authors: Kiat, Tan Hong; Yap, Miranda G.S.; Wang, Daniel I.C.
Variations in critical quality attributes (CQAs) on therapeutic monoclonal antibodies (mAbs) due to cultivation conditions, storage conditions and external stress-factors
Nash, Felicia; Sannum, Emma · 2024
Full title: Variations in critical quality attributes (CQAs) on therapeutic monoclonal antibodies (mAbs) due to cultivation conditions, storage conditions and external stress-factors
Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand
Chua, Gek Kee · 2011
Full title: Process optimization and scale-up for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia (CAH) : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioprocess Engineering at Massey University, Manawatu Campus, New Zealand
Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing
Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP] et al. · 2019
Full title: Assessment of kinetic and metabolic features of two hybridomas in suspension culture for production of two monoclonal antibodies for blood typing
Authors: Silva, Bruna Gabriela; Da Silva Cunha Tamashiro, Wirla Maria; Ferreira, Rossana Rossi [UNESP]; Deffune, Elenice; Suazo, Cláudio Alberto Torres
Sobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes
Bulté Ocaña, Dubhe Beatriz · 2021
Full title: Sobreexpresión del transportador mitocondrial de piruvato en células CHO-S : efecto sobre el metabolismo, producción y calidad de glicoproteínas recombinantes
Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy
Kumpel, Belinda M; Saldova, Radka; Koeleman, Carolien AM et al. · 2021
Full title: Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy