Methanol Feeding Strategies And Do Stat Control In

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Paper Investigating the physiological response of Pichia (Komagataella) pastoris GS115 to the heterologous expression of misfolded proteins using chemostat cultures

Hesketh, Andrew; Castrillo, Juan I.; Sawyer, Trevor et al. · 2013 · Applied Microbiology and Biotechnology · DOI

Full title: Investigating the physiological response of Pichia (Komagataella) pastoris GS115 to the heterologous expression of misfolded proteins using chemostat cultures

Authors: Hesketh, Andrew; Castrillo, Juan I.; Sawyer, Trevor; Archer, David B.; Oliver, Stephen G.

Year: 2013

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-013-5186-1

Paper Expression of functional human sialyltransferases ST6GalNAc5 and ST6GalNAc6 in Pichia pastoris

Krasnoselska, Ganna O.; Lengyel, Márton; Matwiejuk, Martin et al. · 2025 · Applied Microbiology and Biotechnology · DOI

Full title: Expression of functional human sialyltransferases ST6GalNAc5 and ST6GalNAc6 in Pichia pastoris

Authors: Krasnoselska, Ganna O.; Lengyel, Márton; Matwiejuk, Martin; Vuillemin, M. Paul; Molnár-Gábor, Dóra; Meyer, Anne S.; Zeuner, Birgitte

Year: 2025

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-025-13607-x

Paper Production and secretion dynamics of prokaryotic Penicillin G acylase in Pichia pastoris

Borčinová, Martina; Raschmanová, Hana; Zamora, Iwo et al. · 2020 · Applied Microbiology and Biotechnology · DOI

Full title: Production and secretion dynamics of prokaryotic Penicillin G acylase in Pichia pastoris

Authors: Borčinová, Martina; Raschmanová, Hana; Zamora, Iwo; Looser, Verena; Marešová, Helena; Hirsch, Sven; Kyslı́k, Pavel; Kovar, Karin

Year: 2020

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-020-10669-x

Paper Methanol feeding strategies for high-yield production of a collagen-based protein in Komagataella phaffii

Ebbecke, Jan Peter; Schlauch, Domenic; Güler, Cengiz et al. · 2025 · Applied Microbiology and Biotechnology · DOI

Full title: Methanol feeding strategies for high-yield production of a collagen-based protein in Komagataella phaffii

Authors: Ebbecke, Jan Peter; Schlauch, Domenic; Güler, Cengiz; Pirmahboub, Hamidreza; Kara, Selin; Pepelanova, Iliyana

Year: 2025

Venue: Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-025-13675-z

Paper Real-time estimation of biomass and specific growth rate in physiologically variable recombinant fed-batch processes

Wechselberger, Patrick; Sagmeister, Patrick; Herwig, Christoph · 2012 · Bioprocess and Biosystems Engineering · DOI

Full title: Real-time estimation of biomass and specific growth rate in physiologically variable recombinant fed-batch processes

Authors: Wechselberger, Patrick; Sagmeister, Patrick; Herwig, Christoph

Year: 2012

Venue: Bioprocess and Biosystems Engineering

DOI: https://doi.org/10.1007/s00449-012-0848-4

Paper High-level expression of biologically active glycoprotein hormones in Pichia pastoris strains—selection of strain GS115, and not X-33, for the production of biologically active N-glycosylated 15N-labeled phCG

Blanchard, Véronique; Gadkari, Rupali A.; George, A. V. E. et al. · 2008 · Glycoconjugate Journal · DOI

Full title: High-level expression of biologically active glycoprotein hormones in Pichia pastoris strains—selection of strain GS115, and not X-33, for the production of biologically active N-glycosylated 15N-labeled phCG

Authors: Blanchard, Véronique; Gadkari, Rupali A.; George, A. V. E.; Roy, Satarupa Sinha; Gerwig, Gerrit J.; Leeflang, Bas R.; Dighe, Rajan R.; Boelens, Rolf; Kamerling, Johannis P.

Year: 2008

Venue: Glycoconjugate Journal

DOI: https://doi.org/10.1007/s10719-007-9082-8

Paper Structural and functional comparison of SARS-CoV-2-spike receptor binding domain produced in Pichia pastoris and mammalian cells

Arbeitman, Claudia R.; Auge, Gabriela; Blaustein, Matı́as et al. · 2020 · Scientific Reports · DOI

Full title: Structural and functional comparison of SARS-CoV-2-spike receptor binding domain produced in Pichia pastoris and mammalian cells

Authors: Arbeitman, Claudia R.; Auge, Gabriela; Blaustein, Matı́as; Bredeston, Luis M.; Corapi, Enrique; Craig, Patricio O.; Cossio, Leandro A.; Daín, Liliana; D’Alessio, Cecilia; Elias, Fernanda; Fernández, Natalia; Gándola, Yamila B.; Gasulla, Javier; Gorojovsky, Natalia; Gudesblat, Gustavo E.; Herrera, María Georgina; Ibañez, Lorena I.; Idrovo, Tommy; Rando, Matías Iglesias; Kamenetzky, Laura; Nadra, Alejandro D.; Noseda, Diego G.; Paván, Carlos H.; Pavan, María Florencia; Pignataro, María F.; Román, Ernesto A.; Ruberto, Lucas; Rubinstein, Natalia; Santos, Javier; Velázquez, Francisco; Zelada, Alicia M.

Year: 2020

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-020-78711-6

Paper Enhanced cell density cultivation and rapid expression-screening of recombinant Pichia pastoris clones in microscale

Kaushik, Neha; Lamminmäki, Urpo; Khanna, Navin et al. · 2020 · Scientific Reports · DOI

Full title: Enhanced cell density cultivation and rapid expression-screening of recombinant Pichia pastoris clones in microscale

Authors: Kaushik, Neha; Lamminmäki, Urpo; Khanna, Navin; Batra, Gaurav

Year: 2020

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-020-63995-5

Paper Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care

Pérez‐Piñera, Pablo; Han, Ningren; Cleto, Sara et al. · 2016 · Nature Communications · DOI

Full title: Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care

Authors: Pérez‐Piñera, Pablo; Han, Ningren; Cleto, Sara; Cao, Jicong; Purcell, Oliver; Shah, Kartik; Lee, Kevin; Ram, Rajeev J.; Lu, Timothy K.

Year: 2016

Venue: Nature Communications

DOI: https://doi.org/10.1038/ncomms12211

Paper Improvement of a fermentation process for the production of two PfAMA1-DiCo-based malaria vaccine candidates in Pichia pastoris

Kastilan, Robin; Boes, Alexander; Spiegel, Holger et al. · 2017 · Scientific Reports · DOI

Full title: Improvement of a fermentation process for the production of two PfAMA1-DiCo-based malaria vaccine candidates in Pichia pastoris

Authors: Kastilan, Robin; Boes, Alexander; Spiegel, Holger; Voepel, Nadja; Chudobová, Ivana; Hellwig, Stephan; Buyel, Johannes F.; Reimann, Andreas; Fischer, Rainer

Year: 2017

Venue: Scientific Reports

DOI: https://doi.org/10.1038/s41598-017-11819-4

Paper Scaling-up Fermentation of Pichia pastoris to demonstration-scale using new methanol-feeding strategy and increased air pressure instead of pure oxygen supplement

Liu, Wan-Cang; Gong, Ting; Wang, Qinghua et al. · 2016 · Scientific Reports · DOI

Full title: Scaling-up Fermentation of Pichia pastoris to demonstration-scale using new methanol-feeding strategy and increased air pressure instead of pure oxygen supplement

Authors: Liu, Wan-Cang; Gong, Ting; Wang, Qinghua; Liang, Xiao; Chen, Jingjing; Zhu, Ping

Year: 2016

Venue: Scientific Reports

DOI: https://doi.org/10.1038/srep18439

Paper Increased dosage of AOX1 promoter-regulated expression cassettes leads to transcription attenuation of the methanol metabolism in Pichia pastoris

Cámara, Elena; Landes, Nils; Albiol, Joan et al. · 2017 · Scientific Reports · DOI

Full title: Increased dosage of AOX1 promoter-regulated expression cassettes leads to transcription attenuation of the methanol metabolism in Pichia pastoris

Authors: Cámara, Elena; Landes, Nils; Albiol, Joan; Gasser, Brigitte; Mattanovich, Diethard; Ferrer, Pau

Year: 2017

Venue: Scientific Reports

DOI: https://doi.org/10.1038/srep44302

Paper Efficient production of itaconic acid from the single carbon substrate methanol with engineered Komagataella phaffii

Severinsen, Manja Mølgaard; Bachleitner, Simone; Modenese, Viola et al. · 2024 · Biotechnology for Biofuels and Bioproducts · DOI

Full title: Efficient production of itaconic acid from the single carbon substrate methanol with engineered Komagataella phaffii

Authors: Severinsen, Manja Mølgaard; Bachleitner, Simone; Modenese, Viola; Ata, Özge; Mattanovich, Diethard

Year: 2024

Venue: Biotechnology for Biofuels and Bioproducts

DOI: https://doi.org/10.1186/s13068-024-02541-1

Paper Optimizing expression of Nanobody ® molecules in Pichia pastoris through co-expression of auxiliary proteins under methanol and methanol-free conditions

Groeve, Manu De; Laukens, Bram; Schotte, Peter · 2023 · DOI

Full title: Optimizing expression of Nanobody ® molecules in Pichia pastoris through co-expression of auxiliary proteins under methanol and methanol-free conditions

Authors: Groeve, Manu De; Laukens, Bram; Schotte, Peter

Year: 2023

DOI: https://doi.org/10.1101/2023.03.31.535029

Paper Heterologe Expression von Enzymen aus Basidiomyceten in Pichia pastoris

Kelle, Sebastian · 2015 · Institutional Repository of Leibniz Universität Hannover (Leibniz Universität Hannover) · DOI

Full title: Heterologe Expression von Enzymen aus Basidiomyceten in Pichia pastoris

Authors: Kelle, Sebastian

Year: 2015

Venue: Institutional Repository of Leibniz Universität Hannover (Leibniz Universität Hannover)

DOI: https://doi.org/10.15488/8487

Paper Design and development of Pichia pastoris based dengue specific virus-like particles concerted with insights into stress responses during expression using a proteomic approach

Nemani, Satish Kumar · 2015 · Institutional Repository of Leibniz Universität Hannover (Leibniz Universität Hannover) · DOI

Full title: Design and development of Pichia pastoris based dengue specific virus-like particles concerted with insights into stress responses during expression using a proteomic approach

Authors: Nemani, Satish Kumar

Year: 2015

Venue: Institutional Repository of Leibniz Universität Hannover (Leibniz Universität Hannover)

DOI: https://doi.org/10.15488/8540

Paper Metabolic and Process Engineering of Pichia Pastoris for the Production of Value-added Products

Yang, Zhiliang · 2017 · DOI

Full title: Metabolic and Process Engineering of Pichia Pastoris for the Production of Value-added Products

Authors: Yang, Zhiliang

Year: 2017

DOI: https://doi.org/10.20381/ruor-21286

Paper Continuous Cultivation as a Tool Toward the Rational Bioprocess Development With Pichia Pastoris Cell Factory

Nieto‐Taype, Miguel Angel; Garcia‐Ortega, Xavier; Albiol, Joan et al. · 2020 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Continuous Cultivation as a Tool Toward the Rational Bioprocess Development With Pichia Pastoris Cell Factory

Authors: Nieto‐Taype, Miguel Angel; Garcia‐Ortega, Xavier; Albiol, Joan; Montesinos, José Luis González; Valero, Francisco

Year: 2020

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2020.00632

Paper Interval and Possibilistic Methods for Constraint-Based Metabolic Models

Estrada, Francisco Llaneras · 2011 · DOI

Full title: Interval and Possibilistic Methods for Constraint-Based Metabolic Models

Authors: Estrada, Francisco Llaneras

Year: 2011

DOI: https://doi.org/10.4995/thesis/10251/10528

Paper Different approaches to make Pichia pastoris a more versatile expression platform - process, strain and product engineering

Capone, Simona · 2016 · reposiTUm (TU Wien) · DOI

Full title: Different approaches to make Pichia pastoris a more versatile expression platform - process, strain and product engineering

Authors: Capone, Simona

Year: 2016

Venue: reposiTUm (TU Wien)

DOI: https://doi.org/10.34726/hss.2015.34046

Paper Quantitative characterization of a recombinant Pichia pastoris Mut+ strain secreting avidin using transient continuous cultures

Jungo, Carmen · 2007 · Infoscience (Ecole Polytechnique Fédérale de Lausanne) · DOI

Full title: Quantitative characterization of a recombinant Pichia pastoris Mut+ strain secreting avidin using transient continuous cultures

Authors: Jungo, Carmen

Year: 2007

Venue: Infoscience (Ecole Polytechnique Fédérale de Lausanne)

DOI: https://doi.org/10.5075/epfl-thesis-3794

Paper Design of an optimised fed-batch process for insulin precursor production in Pichia pastoris

Bhardwaj, Vinayak · 2011 · Open University of Cape Town (University of Cape Town)

Full title: Design of an optimised fed-batch process for insulin precursor production in Pichia pastoris

Authors: Bhardwaj, Vinayak

Year: 2011

Venue: Open University of Cape Town (University of Cape Town)

Paper Transforming growth factor-Ø in osteoarthritis : the good, the bad or the ugly

Scharstuhl, Alwin · 2003 · Radboud Repository (Radboud University)

Full title: Transforming growth factor-Ø in osteoarthritis : the good, the bad or the ugly

Authors: Scharstuhl, Alwin

Year: 2003

Venue: Radboud Repository (Radboud University)

Paper Upscale of recombinant α-L-rhamnosidase production by Pichia pastoris MutS strain

Markošová, Kristína; Weignerová, Lenka; Rosenberg, Michal et al. · 2015 · Frontiers in Microbiology · DOI

Full title: Upscale of recombinant α-L-rhamnosidase production by Pichia pastoris MutS strain

Authors: Markošová, Kristína; Weignerová, Lenka; Rosenberg, Michal; Křen, Vladimı́r; Rebroš, Martin

Year: 2015

Venue: Frontiers in Microbiology

DOI: https://doi.org/10.3389/fmicb.2015.01140

Paper Development of a New High-Cell Density Fermentation Strategy for Enhanced Production of a Fungus β-Glucosidase in Pichia pastoris

Liu, Wan-Cang; Xiang, Haibo; Zhang, Tao et al. · 2020 · Frontiers in Microbiology · DOI

Full title: Development of a New High-Cell Density Fermentation Strategy for Enhanced Production of a Fungus β-Glucosidase in Pichia pastoris

Authors: Liu, Wan-Cang; Xiang, Haibo; Zhang, Tao; Pang, Xu; Su, Jing; Liu, Hongyu; Ma, Baiping; Yu, Liyan

Year: 2020

Venue: Frontiers in Microbiology

DOI: https://doi.org/10.3389/fmicb.2020.01988

Paper Medium Optimization for Recombinant Human Papillomavirus Type 52 L1 Protein Production in Pichia pastoris GS115 Platform on Bioreactor Scale

Mustopa, Apon Zaenal; Amani, Firouz; Irawan, Herman et al. · 2025 · HAYATI Journal of Biosciences · DOI

Full title: Medium Optimization for Recombinant Human Papillomavirus Type 52 L1 Protein Production in Pichia pastoris GS115 Platform on Bioreactor Scale

Authors: Mustopa, Apon Zaenal; Amani, Firouz; Irawan, Herman; Novianti, Ela; Swasthikawati, Sri; Ekawati, Nurlaili; Nurfatwa, Maritsa; Wahyono, Daniel Joko; Juanssilfero, Ario Betha; Mamangkey, Jendri; Purnomo, Yudi; Hertati, Ai; Wijaya, Hans; Dewi, Kartika Sari; Ningrum, Ratih Asmana

Year: 2025

Venue: HAYATI Journal of Biosciences

DOI: https://doi.org/10.4308/hjb.32.5.1283-1294

Paper Enhancement in Human Insulin Precursor Secretion by Pichia pastoris through Modification of Expression Conditions

Nurdiani, Dini; Hariyatun, Hariyatun; Utami, Nuruliawaty et al. · 2021 · HAYATI Journal of Biosciences · DOI

Full title: Enhancement in Human Insulin Precursor Secretion by Pichia pastoris through Modification of Expression Conditions

Authors: Nurdiani, Dini; Hariyatun, Hariyatun; Utami, Nuruliawaty; Putro, Eko Wahyu; Kusharyoto, Wien

Year: 2021

Venue: HAYATI Journal of Biosciences

DOI: https://doi.org/10.4308/hjb.29.1.22-30

Paper Heterologous expression of Cysteine Protease 8 from Trichomonas foetus in Pichia pastoris

Geethanjali, Karli; Rathnagiri, Polavarapu; Kalarani, V. · 2023 · Journal of Veterinary and Animal Sciences · DOI

Full title: Heterologous expression of Cysteine Protease 8 from Trichomonas foetus in Pichia pastoris

Authors: Geethanjali, Karli; Rathnagiri, Polavarapu; Kalarani, V.

Year: 2023

Venue: Journal of Veterinary and Animal Sciences

DOI: https://doi.org/10.51966/jvas.2023.54.1.13-20

Paper Microbioreactors and Perfusion Bioreactors for Microbial and Mammalian Cell Culture

Ravindran, Selvan; Singh, Pooja; Nene, Sanjay et al. · 2019 · Biotechnology and Bioengineering · DOI

Full title: Microbioreactors and Perfusion Bioreactors for Microbial and Mammalian Cell Culture

Authors: Ravindran, Selvan; Singh, Pooja; Nene, Sanjay; Rale, Vinay; Mhetras, Nutan; Vaidya, Anuradha

Year: 2019

Venue: Biotechnology and Bioengineering

DOI: https://doi.org/10.5772/intechopen.83825

Paper Bioprocess Engineering of Pichia pastoris, an Exciting Host Eukaryotic Cell Expression System

Valero, Francisco · 2013 · InTech eBooks · DOI

Full title: Bioprocess Engineering of Pichia pastoris, an Exciting Host Eukaryotic Cell Expression System

Authors: Valero, Francisco

Year: 2013

Venue: InTech eBooks

DOI: https://doi.org/10.5772/56407

Paper Co-feeding strategy to enhance phytase production in Pichia pastoris

Ndayambaje, Jean Bernard; Meenakshisundaram, S. · 2014 · AFRICAN JOURNAL OF BIOTECHNOLOGY · DOI

Full title: Co-feeding strategy to enhance phytase production in Pichia pastoris

Authors: Ndayambaje, Jean Bernard; Meenakshisundaram, S.

Year: 2014

Venue: AFRICAN JOURNAL OF BIOTECHNOLOGY

DOI: https://doi.org/10.5897/ajb2013.12986

Paper Molecular characterization and expression of H5, N1 and NS1 recombinant proteins of avian influenza virus subtype H5N1 in Pichia pastoris

Abubakar, Mustapha B. · 2011 · Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)

Full title: Molecular characterization and expression of H5, N1 and NS1 recombinant proteins of avian influenza virus subtype H5N1 in Pichia pastoris

Authors: Abubakar, Mustapha B.

Year: 2011

Venue: Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)

Paper Optimization of glutathione production in batch and fed-batch cultures by the wild-type and recombinant strains of the methylotrophic yeast Hansenula polymorphaDL-1

Ubiyvovk, Vira M.; Ananin, Vladimir; Malyshev, Alexander Y et al. · 2011 · BMC Biotechnology · DOI

Full title: Optimization of glutathione production in batch and fed-batch cultures by the wild-type and recombinant strains of the methylotrophic yeast Hansenula polymorphaDL-1

Authors: Ubiyvovk, Vira M.; Ananin, Vladimir; Malyshev, Alexander Y; Kang, Hyun Ah; Sibirny, Andriy А.

Year: 2011

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-11-8

Paper Functional expression of a blood tolerant laccase in Pichia pastoris

Maté, Diana M.; González-Pérez, David; Kittl, Roman et al. · 2013 · BMC Biotechnology · DOI

Full title: Functional expression of a blood tolerant laccase in Pichia pastoris

Authors: Maté, Diana M.; González-Pérez, David; Kittl, Roman; Ludwig, Roland; Alcalde, Miguel

Year: 2013

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-13-38

Paper Improved production of human type II procollagen in the yeast Pichia pastoris in shake flasks by a wireless-controlled fed-batch system

Ruottinen, Maria; Bollók, Mónika; Kögler, Martin et al. · 2008 · BMC Biotechnology · DOI

Full title: Improved production of human type II procollagen in the yeast Pichia pastoris in shake flasks by a wireless-controlled fed-batch system

Authors: Ruottinen, Maria; Bollók, Mónika; Kögler, Martin; Neubauer, Antje; Krause, Mirja; Hämäläinen, Eija‐Riitta; Myllyharju, Johanna; Vasala, Antti; Neubauer, Peter

Year: 2008

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-8-33

Paper A quantitative study of methanol/sorbitol co-feeding process of a Pichia pastoris Mut+/pAOX1-lacZ strain

Niu, Hongxing; Jost, Laurent; Pirlot, Nathalie et al. · 2013 · Microbial Cell Factories · DOI

Full title: A quantitative study of methanol/sorbitol co-feeding process of a Pichia pastoris Mut+/pAOX1-lacZ strain

Authors: Niu, Hongxing; Jost, Laurent; Pirlot, Nathalie; Sassi, Hosni; Daukandt, Marc; Rodriguez, Christian; Fickers, Patrick

Year: 2013

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-12-33

Paper Heterologous expression of leader-less pga gene in Pichia pastoris: intracellular production of prokaryotic enzyme

Marešová, Helena; Marková, Zdena; Valešová, Renáta et al. · 2010 · BMC Biotechnology · DOI

Full title: Heterologous expression of leader-less pga gene in Pichia pastoris: intracellular production of prokaryotic enzyme

Authors: Marešová, Helena; Marková, Zdena; Valešová, Renáta; Sklenář, Jan; Kyslı́k, Pavel

Year: 2010

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-10-7

Paper Expression of recombinant staphylokinase in the methylotrophic yeast Hansenula polymorpha

Moussa, Manal Hassan; Ibrahim, Mahmoud M.; Ghazaly, Maria El et al. · 2012 · BMC Biotechnology · DOI

Full title: Expression of recombinant staphylokinase in the methylotrophic yeast Hansenula polymorpha

Authors: Moussa, Manal Hassan; Ibrahim, Mahmoud M.; Ghazaly, Maria El; Rohde, Jan; Gnoth, Stefan; Anton, Andreas; Kensy, Frank; Müeller, Frank

Year: 2012

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/1472-6750-12-96

Paper A dynamic method based on the specific substrate uptake rate to set up a feeding strategy for Pichia pastoris

Dietzsch, Christian; Spadiut, Oliver; Herwig, Christoph · 2011 · Microbial Cell Factories · DOI

Full title: A dynamic method based on the specific substrate uptake rate to set up a feeding strategy for Pichia pastoris

Authors: Dietzsch, Christian; Spadiut, Oliver; Herwig, Christoph

Year: 2011

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-10-14

Paper Heterologous overexpression of Glomerella cingulata FAD-dependent glucose dehydrogenase in Escherichia coli and Pichia pastoris

Sygmund, Christoph; Staudigl, Petra; Klausberger, Miriam et al. · 2011 · Microbial Cell Factories · DOI

Full title: Heterologous overexpression of Glomerella cingulata FAD-dependent glucose dehydrogenase in Escherichia coli and Pichia pastoris

Authors: Sygmund, Christoph; Staudigl, Petra; Klausberger, Miriam; Pinotsis, Nikos; Djinović‐Carugo, Kristina; Gorton, Lo; Haltrich, Dietmar; Ludwig, Roland

Year: 2011

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-10-106

Paper A fast approach to determine a fed batch feeding profile for recombinant Pichia pastoris strains

Dietzsch, Christian; Spadiut, Oliver; Herwig, Christoph · 2011 · Microbial Cell Factories · DOI

Full title: A fast approach to determine a fed batch feeding profile for recombinant Pichia pastoris strains

Authors: Dietzsch, Christian; Spadiut, Oliver; Herwig, Christoph

Year: 2011

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-10-85

Paper Large-scale functional expression of WT and truncated human adenosine A2A receptor in Pichia pastoris bioreactor cultures

Singh, Shweta; Gras, Adrien; Fiez-Vandal, Cédric et al. · 2008 · Microbial Cell Factories · DOI

Full title: Large-scale functional expression of WT and truncated human adenosine A2A receptor in Pichia pastoris bioreactor cultures

Authors: Singh, Shweta; Gras, Adrien; Fiez-Vandal, Cédric; Ruprecht, Jonathan J.; Rana, Rohini R.; Martínez, Magdalena; Strange, Philip G.; Wagner, Renaud; Byrne, Bernadette

Year: 2008

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-7-28

Paper Heterologous expression of lcc1 gene from Trametes trogii in Pichia pastoris and characterization of the recombinant enzyme.

Colao, M. Ch.; Lupino, Stefania; Garzillo, Anna Maria Vittoria et al. · 2006 · Microbial Cell Factories · DOI

Full title: Heterologous expression of lcc1 gene from Trametes trogii in Pichia pastoris and characterization of the recombinant enzyme.

Authors: Colao, M. Ch.; Lupino, Stefania; Garzillo, Anna Maria Vittoria; Buonocore, Vincenzo; Ruzzi, Maurizio

Year: 2006

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-5-31

Paper Comprehensive clone screening and evaluation of fed-batch strategies in a microbioreactor and lab scale stirred tank bioreactor system: application on Pichia pastoris producing Rhizopus oryzae lipase

Hemmerich, Johannes; Adelantado, Núria; Barrigón, José Manuel et al. · 2014 · Microbial Cell Factories · DOI

Full title: Comprehensive clone screening and evaluation of fed-batch strategies in a microbioreactor and lab scale stirred tank bioreactor system: application on Pichia pastoris producing Rhizopus oryzae lipase

Authors: Hemmerich, Johannes; Adelantado, Núria; Barrigón, José Manuel; Ponte, Xavier; Hörmann, Astrid; Ferrer, Pau; Kensy, Frank; Valero, Francisco

Year: 2014

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-13-36

Paper Regulation of methanol utilisation pathway genes in yeasts.

Hartner, Franz Stefan; Glieder, Anton · 2006 · Microbial Cell Factories · DOI

Full title: Regulation of methanol utilisation pathway genes in yeasts.

Authors: Hartner, Franz Stefan; Glieder, Anton

Year: 2006

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-5-39

Paper Application of simple fed-batch technique to high-level secretory production of insulin precursor using Pichia pastoris with subsequent purification and conversion to human insulin

Gurramkonda, Chandrasekhar; Polez, Sulena; Skoko, Nataša et al. · 2010 · Microbial Cell Factories · DOI

Full title: Application of simple fed-batch technique to high-level secretory production of insulin precursor using Pichia pastoris with subsequent purification and conversion to human insulin

Authors: Gurramkonda, Chandrasekhar; Polez, Sulena; Skoko, Nataša; Adnan, Ahmad; Gäbel, Thomas; Chugh, Dipti A; Swaminathan, S.; Khanna, Navin; Tisminetzky, Sergio; Rinas, Ursula

Year: 2010

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-9-31

Paper Versatile modeling and optimization of fed batch processes for the production of secreted heterologous proteins with Pichia pastoris

Maurer, Michael; Kühleitner, Manfred; Gasser, Brigitte et al. · 2006 · Microbial Cell Factories · DOI

Full title: Versatile modeling and optimization of fed batch processes for the production of secreted heterologous proteins with Pichia pastoris

Authors: Maurer, Michael; Kühleitner, Manfred; Gasser, Brigitte; Mattanovich, Diethard

Year: 2006

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-5-37

Paper Operational strategies, monitoring and control of heterologous protein production in the methylotrophic yeast Pichia pastoris under different promoters: A review

Cós, Oriol; Ramón, Ramón; Montesinos, José Luis González et al. · 2006 · Microbial Cell Factories · DOI

Full title: Operational strategies, monitoring and control of heterologous protein production in the methylotrophic yeast Pichia pastoris under different promoters: A review

Authors: Cós, Oriol; Ramón, Ramón; Montesinos, José Luis González; Valero, Francisco

Year: 2006

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-5-17

Paper Genome-scale metabolic reconstructions of Pichia stipitis and Pichia pastoris and in silico evaluation of their potentials

Caspeta, Luis; Shoaie, Saeed; Ågren, Rasmus et al. · 2012 · BMC Systems Biology · DOI

Full title: Genome-scale metabolic reconstructions of Pichia stipitis and Pichia pastoris and in silico evaluation of their potentials

Authors: Caspeta, Luis; Shoaie, Saeed; Ågren, Rasmus; Nookaew, Intawat; Nielsen, Jens

Year: 2012

Venue: BMC Systems Biology

DOI: https://doi.org/10.1186/1752-0509-6-24

Paper An effective combination of codon optimization, gene dosage, and process optimization for high-level production of fibrinolytic enzyme in Komagataella phaffii (Pichia pastoris)

Che, Zhiqun; Cao, Xiaoyan; Chen, Guiguang et al. · 2020 · BMC Biotechnology · DOI

Full title: An effective combination of codon optimization, gene dosage, and process optimization for high-level production of fibrinolytic enzyme in Komagataella phaffii (Pichia pastoris)

Authors: Che, Zhiqun; Cao, Xiaoyan; Chen, Guiguang; Liang, Zhiqun

Year: 2020

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/s12896-020-00654-7

Paper Functional recombinant protein is present in the pre-induction phases of Pichia pastoris cultures when grown in bioreactors, but not shake-flasks

Bawa, Zharain; Routledge, Sarah J; Jamshad, Mohammed et al. · 2014 · Microbial Cell Factories · DOI

Full title: Functional recombinant protein is present in the pre-induction phases of Pichia pastoris cultures when grown in bioreactors, but not shake-flasks

Authors: Bawa, Zharain; Routledge, Sarah J; Jamshad, Mohammed; Clare, Michelle; Sarkar, Debasmita; Dickerson, Ian M.; Ganzlin, Markus; Poyner, David R.; Bill, Roslyn M.

Year: 2014

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-014-0127-y

Paper Engineered Pichia pastoris for enhanced production of S-adenosylmethionine

Kamarthapu, Venu; Srinivas, R.; Rao, Khareedu Venkateswara et al. · 2013 · AMB Express · DOI

Full title: Engineered Pichia pastoris for enhanced production of S-adenosylmethionine

Authors: Kamarthapu, Venu; Srinivas, R.; Rao, Khareedu Venkateswara; Reddy, Vudem Dashavantha

Year: 2013

Venue: AMB Express

DOI: https://doi.org/10.1186/2191-0855-3-40

Paper Dynamic genome-scale metabolic modeling of the yeast Pichia pastoris

Saitua, Francisco; Torres, Paulina; Pérez‐Correa, José Ricardo et al. · 2017 · BMC Systems Biology · DOI

Full title: Dynamic genome-scale metabolic modeling of the yeast Pichia pastoris

Authors: Saitua, Francisco; Torres, Paulina; Pérez‐Correa, José Ricardo; Agosín, Eduardo

Year: 2017

Venue: BMC Systems Biology

DOI: https://doi.org/10.1186/s12918-017-0408-2

Paper Treatment with surfactants enables quantification of translational activity by O-propargyl-puromycin labelling in yeast

Staudacher, Jennifer; Rebnegger, Corinna; Gasser, Brigitte · 2021 · BMC Microbiology · DOI

Full title: Treatment with surfactants enables quantification of translational activity by O-propargyl-puromycin labelling in yeast

Authors: Staudacher, Jennifer; Rebnegger, Corinna; Gasser, Brigitte

Year: 2021

Venue: BMC Microbiology

DOI: https://doi.org/10.1186/s12866-021-02185-3

Paper Developing a scalable model of recombinant protein yield from Pichia pastoris: the influence of culture conditions, biomass and induction regime

Holmes, William J.; Darby, Richard A. J.; Wilks, Martin DB et al. · 2009 · Microbial Cell Factories · DOI

Full title: Developing a scalable model of recombinant protein yield from Pichia pastoris: the influence of culture conditions, biomass and induction regime

Authors: Holmes, William J.; Darby, Richard A. J.; Wilks, Martin DB; Smith, Rodney; Bill, Roslyn M.

Year: 2009

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/1475-2859-8-35

Paper The effect of hypoxia on the lipidome of recombinant Pichia pastoris

Adelantado, Núria; Tarazona, Pablo; Grillitsch, Karlheinz et al. · 2017 · Microbial Cell Factories · DOI

Full title: The effect of hypoxia on the lipidome of recombinant Pichia pastoris

Authors: Adelantado, Núria; Tarazona, Pablo; Grillitsch, Karlheinz; Garcia‐Ortega, Xavier; Monforte, Sergi; Valero, Francisco; Feußner, Ivo; Daum, Günther; Ferrer, Pau

Year: 2017

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-017-0699-4

Paper Specific growth rate governs AOX1 gene expression, affecting the production kinetics of Pichia pastoris (Komagataella phaffii) PAOX1-driven recombinant producer strains with different target gene dosage

Garrigós‐Martínez, Javier; Nieto‐Taype, Miguel Angel; Gasset-Franch, Arnau et al. · 2019 · Microbial Cell Factories · DOI

Full title: Specific growth rate governs AOX1 gene expression, affecting the production kinetics of Pichia pastoris (Komagataella phaffii) PAOX1-driven recombinant producer strains with different target gene dosage

Authors: Garrigós‐Martínez, Javier; Nieto‐Taype, Miguel Angel; Gasset-Franch, Arnau; Montesinos, José Luis González; Garcia‐Ortega, Xavier; Valero, Francisco

Year: 2019

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-019-1240-8

Paper Development of a mixed feed strategy for a recombinant Pichia pastoris strain producing with a de-repression promoter

Capone, Simona; Horvat, Jernej; Herwig, Christoph et al. · 2015 · Microbial Cell Factories · DOI

Full title: Development of a mixed feed strategy for a recombinant Pichia pastoris strain producing with a de-repression promoter

Authors: Capone, Simona; Horvat, Jernej; Herwig, Christoph; Spadiut, Oliver

Year: 2015

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-015-0292-7

Paper Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up

Madhavan, Aravind; Arun, K. B.; Sindhu, Raveendran et al. · 2021 · Microbial Cell Factories · DOI

Full title: Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up

Authors: Madhavan, Aravind; Arun, K. B.; Sindhu, Raveendran; Krishnamoorthy, Jayaram; Reshmy, R.; Sirohi, Ranjna; Pugazhendi, Arivalagan; Awasthi, Mukesh Kumar; Szakács, George; Binod, Parameswaran

Year: 2021

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-021-01617-z

Paper Development of a fed-batch process for a recombinant Pichia pastoris Δoch1 strain expressing a plant peroxidase

Gmeiner, Christoph; Saadati, Amirhossein; Maresch, Daniel et al. · 2015 · Microbial Cell Factories · DOI

Full title: Development of a fed-batch process for a recombinant Pichia pastoris Δoch1 strain expressing a plant peroxidase

Authors: Gmeiner, Christoph; Saadati, Amirhossein; Maresch, Daniel; Krasteva, Stanimira; Frank, Manuela; Altmann, Friedrich; Herwig, Christoph; Spadiut, Oliver

Year: 2015

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-014-0183-3

Paper An artificial neural network for membrane-bound catechol-O-methyltransferase biosynthesis with Pichia pastoris methanol-induced cultures

Pedro, Augusto Q.; Martins, Luís C.; Dias, João M.L. et al. · 2015 · Microbial Cell Factories · DOI

Full title: An artificial neural network for membrane-bound catechol-O-methyltransferase biosynthesis with Pichia pastoris methanol-induced cultures

Authors: Pedro, Augusto Q.; Martins, Luís C.; Dias, João M.L.; Bonifácio, Maria João; Queiroz, João A.; Passarinha, Luís A.

Year: 2015

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-015-0304-7

Paper Validation of an FBA model for Pichia pastoris in chemostat cultures

Morales, Yeimy; Tortajada, Marta; Picó, Jesús et al. · 2014 · BMC Systems Biology · DOI

Full title: Validation of an FBA model for Pichia pastoris in chemostat cultures

Authors: Morales, Yeimy; Tortajada, Marta; Picó, Jesús; Vehı́, Josep; Llaneras, Francisco

Year: 2014

Venue: BMC Systems Biology

DOI: https://doi.org/10.1186/s12918-014-0142-y

Paper A novel bi-directional promoter system allows tunable recombinant protein production in Pichia pastoris

Rajamanickam, Vignesh; Metzger, Karl; Schmid, Christian et al. · 2017 · Microbial Cell Factories · DOI

Full title: A novel bi-directional promoter system allows tunable recombinant protein production in Pichia pastoris

Authors: Rajamanickam, Vignesh; Metzger, Karl; Schmid, Christian; Spadiut, Oliver

Year: 2017

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-017-0768-8

Paper Optimization of construct design and fermentation strategy for the production of bioactive ATF-SAP, a saporin based anti-tumoral uPAR-targeted chimera

Provenzano, Alfredo Errico; Posteri, Riccardo; Giansanti, Francesco et al. · 2016 · Microbial Cell Factories · DOI

Full title: Optimization of construct design and fermentation strategy for the production of bioactive ATF-SAP, a saporin based anti-tumoral uPAR-targeted chimera

Authors: Provenzano, Alfredo Errico; Posteri, Riccardo; Giansanti, Francesco; Angelucci, Francesco; Flavell, Sopsamorn U.; Flavell, David J.; Fabbrini, Maria Serena; Porro, Danilo; Ippoliti, Rodolfo; Ceriotti, Aldo; Branduardi, Paola; Vago, Riccardo

Year: 2016

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-016-0589-1

Paper Optimizing expression of Nanobody® molecules in Pichia pastoris through co-expression of auxiliary proteins under methanol and methanol-free conditions

Groeve, Manu De; Laukens, Bram; Schotte, Peter · 2023 · Microbial Cell Factories · DOI

Full title: Optimizing expression of Nanobody® molecules in Pichia pastoris through co-expression of auxiliary proteins under methanol and methanol-free conditions

Authors: Groeve, Manu De; Laukens, Bram; Schotte, Peter

Year: 2023

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-023-02132-z

Paper Uncoupling protein production from growth: different strategies for intracellular and secreted proteins in yeast

Temelli, Nuran; Baris, Willem H.; Weusthuis, Ruud A. et al. · 2025 · Microbial Cell Factories · DOI

Full title: Uncoupling protein production from growth: different strategies for intracellular and secreted proteins in yeast

Authors: Temelli, Nuran; Baris, Willem H.; Weusthuis, Ruud A.; Bisschops, Markus M.M.

Year: 2025

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-025-02848-0

Paper Scalable production and application of Pichia pastoris whole cell catalysts expressing human cytochrome P450 2C9

Garrigós‐Martínez, Javier; Weninger, Astrid; Montesinos, José Luis González et al. · 2021 · Microbial Cell Factories · DOI

Full title: Scalable production and application of Pichia pastoris whole cell catalysts expressing human cytochrome P450 2C9

Authors: Garrigós‐Martínez, Javier; Weninger, Astrid; Montesinos, José Luis González; Schmid, Christian; Valero, Francisco; Rinnofner, Claudia; Glieder, Anton; Garcia‐Ortega, Xavier

Year: 2021

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-021-01577-4

Paper Methanol bioconversion into C3, C4, and C5 platform chemicals by the yeast Ogataea polymorpha

Wefelmeier, Katrin; Schmitz, Simone; Kösters, Benjamin Jonas et al. · 2024 · Microbial Cell Factories · DOI

Full title: Methanol bioconversion into C3, C4, and C5 platform chemicals by the yeast Ogataea polymorpha

Authors: Wefelmeier, Katrin; Schmitz, Simone; Kösters, Benjamin Jonas; Liebal, Ulf W.; Blank, Lars M.

Year: 2024

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-023-02283-z

Paper The nutritional composition and cell size of microbial biomass for food applications are defined by the growth conditions

Sakarika, Myrsini; Kerckhof, Frederiek‐Maarten; Peteghem, L. Van et al. · 2023 · Microbial Cell Factories · DOI

Full title: The nutritional composition and cell size of microbial biomass for food applications are defined by the growth conditions

Authors: Sakarika, Myrsini; Kerckhof, Frederiek‐Maarten; Peteghem, L. Van; Pereira, Alexandra; Bossche, Tim Van Den; Bouwmeester, Robbin; Gabriels, Ralf; Haver, Delphi Van; Ulčar, Barbara; Martens, Lennart; Impens, Francis; Boon, Nico; Ganigué, Ramon; Rabaey, Korneel

Year: 2023

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-023-02265-1

Paper Economical production of Pichia pastoris single cell protein from methanol at industrial pilot scale

Jiao, Meng; Liu, Shufan; Gao, Le et al. · 2023 · Microbial Cell Factories · DOI

Full title: Economical production of Pichia pastoris single cell protein from methanol at industrial pilot scale

Authors: Jiao, Meng; Liu, Shufan; Gao, Le; Hong, Kai; Liu, Shuguang; Wu, Xin

Year: 2023

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-023-02198-9

Paper Bi-directionalized promoter systems allow methanol-free production of hard-to-express peroxygenases with Komagataella Phaffii

Besleaga, Mihail; Zimmermann, Christian; Ebner, Katharina et al. · 2024 · Microbial Cell Factories · DOI

Full title: Bi-directionalized promoter systems allow methanol-free production of hard-to-express peroxygenases with Komagataella Phaffii

Authors: Besleaga, Mihail; Zimmermann, Christian; Ebner, Katharina; Mach, Robert L.; Mach‐Aigner, Astrid R.; Geier, Martina; Glieder, Anton; Spadiut, Oliver; Kopp, Julian

Year: 2024

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-024-02451-9

Paper Enhancing the secretion pathway maximizes the effects of mixed feeding strategy for glucose oxidase production in the methylotrophic yeast Pichia pastoris

Bankefa, Olufemi Emmanuel; Wang, Meiyu; Zhu, Taicheng et al. · 2018 · Bioresources and Bioprocessing · DOI

Full title: Enhancing the secretion pathway maximizes the effects of mixed feeding strategy for glucose oxidase production in the methylotrophic yeast Pichia pastoris

Authors: Bankefa, Olufemi Emmanuel; Wang, Meiyu; Zhu, Taicheng; Li, Yin

Year: 2018

Venue: Bioresources and Bioprocessing

DOI: https://doi.org/10.1186/s40643-018-0211-y

Paper Recombinant production of Paenibacillus wynnii β-galactosidase with Komagataella phaffii

Bechtel, Anna; Seitl, Ines; Proß, Eva et al. · 2024 · Microbial Cell Factories · DOI

Full title: Recombinant production of Paenibacillus wynnii β-galactosidase with Komagataella phaffii

Authors: Bechtel, Anna; Seitl, Ines; Proß, Eva; Hetzel, Frank; Keutgen, Mario; Fischer, Lutz

Year: 2024

Venue: Microbial Cell Factories

DOI: https://doi.org/10.1186/s12934-024-02544-5

Paper Candida boidinii isolates from olive curation water: a promising platform for methanol-based biomanufacturing

Mota, Marta N.; Palma, Margarida; Sá‐Correia, Isabel · 2024 · AMB Express · DOI

Full title: Candida boidinii isolates from olive curation water: a promising platform for methanol-based biomanufacturing

Authors: Mota, Marta N.; Palma, Margarida; Sá‐Correia, Isabel

Year: 2024

Venue: AMB Express

DOI: https://doi.org/10.1186/s13568-024-01754-9

Paper Expression and characterization of a novel 1,3-regioselective cold-adapted lipase from Rhizomucor endophyticus suitable for biodiesel synthesis

Yan, Qiaojuan; Duan, Xiaojie; Liu, Yu et al. · 2016 · Biotechnology for Biofuels · DOI

Full title: Expression and characterization of a novel 1,3-regioselective cold-adapted lipase from Rhizomucor endophyticus suitable for biodiesel synthesis

Authors: Yan, Qiaojuan; Duan, Xiaojie; Liu, Yu; Jiang, Zhengqiang; Yang, Shaoqing

Year: 2016

Venue: Biotechnology for Biofuels

DOI: https://doi.org/10.1186/s13068-016-0501-6

Paper Secretory expression of cyclohexanone monooxygenase by methylotrophic yeast for efficient omeprazole sulfide bio-oxidation

Li, Yajing; Zheng, Yu‐Cong; Geng, Qiang et al. · 2021 · Bioresources and Bioprocessing · DOI

Full title: Secretory expression of cyclohexanone monooxygenase by methylotrophic yeast for efficient omeprazole sulfide bio-oxidation

Authors: Li, Yajing; Zheng, Yu‐Cong; Geng, Qiang; Liu, Feng; Zhang, Zhi‐Jun; Xu, Jian‐He; Yu, Hui‐Lei

Year: 2021

Venue: Bioresources and Bioprocessing

DOI: https://doi.org/10.1186/s40643-021-00430-1

Paper Metabolic engineering of Komagataella phaffii for enhanced 3-hydroxypropionic acid (3-HP) production from methanol

Àvila-Cabré, Sílvia; Albiol, Joan; Ferrer, Pau · 2025 · Journal of Biological Engineering · DOI

Full title: Metabolic engineering of Komagataella phaffii for enhanced 3-hydroxypropionic acid (3-HP) production from methanol

Authors: Àvila-Cabré, Sílvia; Albiol, Joan; Ferrer, Pau

Year: 2025

Venue: Journal of Biological Engineering

DOI: https://doi.org/10.1186/s13036-025-00488-x

Paper Avoiding overflow metabolite formation in Komagataella phaffii fermentations to enhance recombinant protein production

Steimann, Thomas; Wegmann, Judith; Espinosa, Monica I. et al. · 2024 · Journal of Biological Engineering · DOI

Full title: Avoiding overflow metabolite formation in Komagataella phaffii fermentations to enhance recombinant protein production

Authors: Steimann, Thomas; Wegmann, Judith; Espinosa, Monica I.; Blank, Lars M.; Büchs, Jochen; Mann, Marcel; Magnus, Jørgen Barsett

Year: 2024

Venue: Journal of Biological Engineering

DOI: https://doi.org/10.1186/s13036-024-00453-0

Paper Efficient production of itaconic acid from the single-carbon substrate methanol with engineered Komagataella phaffii

Severinsen, Manja Mølgaard; Bachleitner, Simone; Modenese, Viola et al. · 2024 · Biotechnology for Biofuels and Bioproducts · DOI

Full title: Efficient production of itaconic acid from the single-carbon substrate methanol with engineered Komagataella phaffii

Authors: Severinsen, Manja Mølgaard; Bachleitner, Simone; Modenese, Viola; Ata, Özge; Mattanovich, Diethard

Year: 2024

Venue: Biotechnology for Biofuels and Bioproducts

DOI: https://doi.org/10.1186/s13068-024-02541-1

Paper Current advances for omics-guided process optimization of microbial manufacturing

Wan, Shengtong; Liu, Xin; Sun, Wentao et al. · 2023 · Bioresources and Bioprocessing · DOI

Full title: Current advances for omics-guided process optimization of microbial manufacturing

Authors: Wan, Shengtong; Liu, Xin; Sun, Wentao; Lv, Bo; Li, Chun

Year: 2023

Venue: Bioresources and Bioprocessing

DOI: https://doi.org/10.1186/s40643-023-00647-2

Paper Combined Strategies for Improving the Production of Recombinant Rhizopus oryzae Lipase in Pichia pastoris

Li, Xun; He, Xiaoyun; Li, Zhilin et al. · 2013 · BioResources · DOI

Full title: Combined Strategies for Improving the Production of Recombinant Rhizopus oryzae Lipase in Pichia pastoris

Authors: Li, Xun; He, Xiaoyun; Li, Zhilin; Wang, Fei

Year: 2013

Venue: BioResources

DOI: https://doi.org/10.15376/biores.8.2.2867-2880

Paper Extracellular expression, purification and bioreactor production of tambaqui (Colossoma macropomum) growth hormone in the yeast Komagataella phaffii (formerly Pichia pastoris)

Sadalla-Pinto, Elson Antônio; ANDRADE, Edmar de; Carmo, Edson Júnior do et al. · 2024 · Acta Amazonica · DOI

Full title: Extracellular expression, purification and bioreactor production of tambaqui (Colossoma macropomum) growth hormone in the yeast Komagataella phaffii (formerly Pichia pastoris)

Authors: Sadalla-Pinto, Elson Antônio; ANDRADE, Edmar de; Carmo, Edson Júnior do; SOUZA-NETO, Júlio Nino de; BATISTA, Larissa Matos; BENTES-SOUSA, Alexandra Regina; Mariúba, Luís André Morais; Passos, Douglas de França; Fernandes, Rodrigo Pimentel; Pereira, Nei; Porto, Jorge Ivan Rebelo; Astolfi‐Filho, Spartaco

Year: 2024

Venue: Acta Amazonica

DOI: https://doi.org/10.1590/1809-4392202301791

Paper Development of a Cost-Effective Process for the Heterologous Production of SARS-CoV-2 Spike Receptor Binding Domain (RBD) Using Pichia pastoris in Stirred-Tank Bioreactor

Noseda, Diego G.; D’Alessio, Cecilia; Santos, Javier et al. · 2023 · Fermentation · DOI

Full title: Development of a Cost-Effective Process for the Heterologous Production of SARS-CoV-2 Spike Receptor Binding Domain (RBD) Using Pichia pastoris in Stirred-Tank Bioreactor

Authors: Noseda, Diego G.; D’Alessio, Cecilia; Santos, Javier; Idrovo-Hidalgo, Tommy; Pignataro, Florencia; Wetzler, Diana E.; Gentili, Hernán; Nadra, Alejandro D.; Román, Ernesto A.; Paván, Carlos; Ruberto, Lucas

Year: 2023

Venue: Fermentation

DOI: https://doi.org/10.3390/fermentation9060497

Paper Enhancing Sustainability and Productivity in Komagataella phaffii Fermentation: A Techno-Economic Comparison of Fed-Batch and Continuous Cultivation with Mixed Induction Strategies

Yamanie, Almir; Magalhães, Salomé de Sá; Wijayadikusumah, Acep R. et al. · 2026 · Preprints.org · DOI

Full title: Enhancing Sustainability and Productivity in Komagataella phaffii Fermentation: A Techno-Economic Comparison of Fed-Batch and Continuous Cultivation with Mixed Induction Strategies

Authors: Yamanie, Almir; Magalhães, Salomé de Sá; Wijayadikusumah, Acep R.; Nurainy, Neni; Keshavarz-Moore, Eli

Year: 2026

Venue: Preprints.org

DOI: https://doi.org/10.20944/preprints202601.1265.v1

Paper Leveraging Historical Process Data for Recombinant P. pastoris Fermentation Hybrid Deep Modeling and Model Predictive Control Development

Bolmanis, Emīls; Galvanauskas, Vytautas; Grīgs, Oskars et al. · 2025 · Preprints.org · DOI

Full title: Leveraging Historical Process Data for Recombinant P. pastoris Fermentation Hybrid Deep Modeling and Model Predictive Control Development

Authors: Bolmanis, Emīls; Galvanauskas, Vytautas; Grīgs, Oskars; Vanags, Juris; Kazāks, Andris

Year: 2025

Venue: Preprints.org

DOI: https://doi.org/10.20944/preprints202506.2217.v1

Paper Two-phase fed-batch modification for 48 hour peak expression of hepatitis B surface antigen in Pichia pastoris shake flask system

Tam, Yew Joon; Allaudin, Zeenathul Nazariah; Rezaei, Morvarid Akhavan et al. · 2014 · Open Life Sciences · DOI

Full title: Two-phase fed-batch modification for 48 hour peak expression of hepatitis B surface antigen in Pichia pastoris shake flask system

Authors: Tam, Yew Joon; Allaudin, Zeenathul Nazariah; Rezaei, Morvarid Akhavan; Lila, Mohd Azmi Mohd; Bahaman, Abdul; Lo, Sewn Cen; Tan, Joo Shun

Year: 2014

Venue: Open Life Sciences

DOI: https://doi.org/10.2478/s11535-014-0309-y

Paper Fed-Batch Production of Saccharomyces cerevisiae L-Asparaginase II by Recombinant Pichia pastoris MUTs Strain

Rodrigues, David; Pillaca‐Pullo, Omar; Torres‐Obreque, Karin Mariana et al. · 2019 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Fed-Batch Production of Saccharomyces cerevisiae L-Asparaginase II by Recombinant Pichia pastoris MUTs Strain

Authors: Rodrigues, David; Pillaca‐Pullo, Omar; Torres‐Obreque, Karin Mariana; Flores-Santos, Juan Carlos; Sánchez‐Moguel, Ignacio; Pimenta, Marcela Valente; Basi, Tajindar; Converti, Attílio; Lopes, André Moreni; Monteiro, Gisele; Fonseca, Luís P.; Pessoa, Adalberto

Year: 2019

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2019.00016

Paper Innovative Bioprocess Strategies Combining Physiological Control and Strain Engineering of Pichia pastoris to Improve Recombinant Protein Production

Gasset, Arnau; Garcia‐Ortega, Xavier; Garrigós‐Martínez, Javier et al. · 2022 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Innovative Bioprocess Strategies Combining Physiological Control and Strain Engineering of Pichia pastoris to Improve Recombinant Protein Production

Authors: Gasset, Arnau; Garcia‐Ortega, Xavier; Garrigós‐Martínez, Javier; Valero, Francisco; Montesinos, José Luis González

Year: 2022

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2022.818434

Paper PAOX1 expression in mixed-substrate continuous cultures of Komagataella phaffii (Pichia pastoris) is completely determined by methanol consumption regardless of the secondary carbon source

Singh, Anamika; Narang, Atul · 2023 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: PAOX1 expression in mixed-substrate continuous cultures of Komagataella phaffii (Pichia pastoris) is completely determined by methanol consumption regardless of the secondary carbon source

Authors: Singh, Anamika; Narang, Atul

Year: 2023

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2023.1123703

Paper Bioproduction of the Recombinant Sweet Protein Thaumatin: Current State of the Art and Perspectives

Joseph, Jewel Ann; Akkermans, Simen; Nimmegeers, Philippe et al. · 2019 · Frontiers in Microbiology · DOI

Full title: Bioproduction of the Recombinant Sweet Protein Thaumatin: Current State of the Art and Perspectives

Authors: Joseph, Jewel Ann; Akkermans, Simen; Nimmegeers, Philippe; Impe, Jan Van

Year: 2019

Venue: Frontiers in Microbiology

DOI: https://doi.org/10.3389/fmicb.2019.00695

Paper Continuous Process Verification 4.0 application in upstream: adaptiveness implementation managed by AI in the hypoxic bioprocess of the Pichia pastoris cell factory

Gasset, Arnau; Wijngaarden, Joeri van; Mirabent, Ferran et al. · 2024 · Frontiers in Bioengineering and Biotechnology · DOI

Full title: Continuous Process Verification 4.0 application in upstream: adaptiveness implementation managed by AI in the hypoxic bioprocess of the Pichia pastoris cell factory

Authors: Gasset, Arnau; Wijngaarden, Joeri van; Mirabent, Ferran; Sales‐Vallverdú, Albert; Garcia‐Ortega, Xavier; Montesinos, José Luis González; Manzano, Toni; Valero, Francisco

Year: 2024

Venue: Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2024.1439638

Paper Enhancement of thermoalkaliphilic xylanase production by Pichia pastoris through novel fed-batch strategy in high cell-density fermentation

Shang, Tingting; Si, Dayong; Zhang, Dongyan et al. · 2017 · BMC Biotechnology · DOI

Full title: Enhancement of thermoalkaliphilic xylanase production by Pichia pastoris through novel fed-batch strategy in high cell-density fermentation

Authors: Shang, Tingting; Si, Dayong; Zhang, Dongyan; Liu, Xuhui; Zhao, Longmei; Hu, Cong; Fu, Yu; Zhang, Rijun

Year: 2017

Venue: BMC Biotechnology

DOI: https://doi.org/10.1186/s12896-017-0361-6

Paper Improved microscale cultivation of Pichia pastoris for clonal screening

Eck, Alexander; Schmidt, Matthias; Hamer, Stefanie Nicole et al. · 2018 · Fungal Biology and Biotechnology · DOI

Full title: Improved microscale cultivation of Pichia pastoris for clonal screening

Authors: Eck, Alexander; Schmidt, Matthias; Hamer, Stefanie Nicole; Ruff, Anna Joëlle; Förster, Jan Janosch; Schwaneberg, Ulrich; Blank, Lars M.; Wiechert, Wolfgang; Oldiges, Marco

Year: 2018

Venue: Fungal Biology and Biotechnology

DOI: https://doi.org/10.1186/s40694-018-0053-6

Thesis Modelling and Optimization of Fed-Batch Filamentous Fungal Fermentation

Titica, M.; Bodizs, L.; Lei, F. et al. · 2004 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Modelling and Optimization of Fed-Batch Filamentous Fungal Fermentation

Authors: Titica, M.; Bodizs, L.; Lei, F.; Srinivasan, B.; Dochain, D.; Bonvin, D.

Year: 2004

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/176798

Thesis Bioreactor Controls for High Oxygen Uptake Rate (OUR) Demand Processes

Cho, Hyun Woo · 2019 · Johns Hopkins University · DOI

Full title: Bioreactor Controls for High Oxygen Uptake Rate (OUR) Demand Processes

Authors: Cho, Hyun Woo

Year: 2019

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/60474

Thesis Control of yeast fed-batch process through regulation of extracellular ethanol concentration

Cannizzaro, Christopher; Valentinotti, Sergio; Stockar, Urs · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Control of yeast fed-batch process through regulation of extracellular ethanol concentration

Authors: Cannizzaro, Christopher; Valentinotti, Sergio; Stockar, Urs

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226110

Thesis Probing Control of a Fedbatch Fermentation. Simulation and Implementation in ABB Industrial IT

Li, Tory · 2004 · Lund University Student Papers · DOI

Full title: Probing Control of a Fedbatch Fermentation. Simulation and Implementation in ABB Industrial IT

Authors: Li, Tory

Year: 2004

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/8848000

Thesis Development of optimal fermentation expression systems for recombinant proteins: a thesis submitted in partial fulfilment of the requirements for the degree of Masters in Technology at Massey University

Manderson, Daniel · 2017 · Massey University · DOI

Full title: Development of optimal fermentation expression systems for recombinant proteins: a thesis submitted in partial fulfilment of the requirements for the degree of Masters in Technology at Massey University

Authors: Manderson, Daniel

Year: 2017

Venue: Massey University

DOI: http://hdl.handle.net/10179/12019

Thesis Expression of human epidermal growth factor in pichia pastoris and optimization of fermentation conditions

Eissazadeh, Samira · 2012 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Expression of human epidermal growth factor in pichia pastoris and optimization of fermentation conditions

Authors: Eissazadeh, Samira

Year: 2012

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/31605/1/FBSB%202012%2030R.pdf

Thesis Development of Fermentation Technique for High Cell Density Cultivation of Baker's Yeast (Saccharomyces Cerevisae)

Ahmad Ariff · 2005 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Development of Fermentation Technique for High Cell Density Cultivation of Baker's Yeast (Saccharomyces Cerevisae)

Authors: Ahmad Ariff

Year: 2005

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/6761/1/IB_2005_8.pdf

Thesis Fed-Batch Production of Saccharomyces cerevisiae L-Asparaginase II by Recombinant Pichia pastoris MUTs Strain

Pessoa Junior, Adalberto · 2019 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Fed-Batch Production of Saccharomyces cerevisiae L-Asparaginase II by Recombinant Pichia pastoris MUTs Strain

Authors: Pessoa Junior, Adalberto

Year: 2019

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.3389/fbioe.2019.00016

Thesis Production of protegrin-1 with a matrix metalloproteinase/elastase cleavage site and its therapeutic potential for skin wound infections

Hill, Emily · 2017 · University of Guelph · DOI

Full title: Production of protegrin-1 with a matrix metalloproteinase/elastase cleavage site and its therapeutic potential for skin wound infections

Authors: Hill, Emily

Year: 2017

Venue: University of Guelph

DOI: http://hdl.handle.net/10214/11495

Thesis Design of a cultivation medium for protein production in Pichia pastoris based on genome-wide biological understanding

Matthews, Catherine Bartlett. · 2019 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Design of a cultivation medium for protein production in Pichia pastoris based on genome-wide biological understanding

Authors: Matthews, Catherine Bartlett.

Year: 2019

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/122528

Thesis Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Hong, Moo Sun · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Authors: Hong, Moo Sun

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/138943

Thesis Quantitative characterization of a recombinant Pichia pastoris Mut+ strain secreting avidin using transient continuous cultures

Jungo, Carmen · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Quantitative characterization of a recombinant Pichia pastoris Mut+ strain secreting avidin using transient continuous cultures

Authors: Jungo, Carmen

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/6151

Thesis Probing Control : Analysis and Design with Application to Fed-Batch Bioreactors

Velut, Stéphane · 2005 · Lund University (LUP) · DOI

Full title: Probing Control : Analysis and Design with Application to Fed-Batch Bioreactors

Authors: Velut, Stéphane

Year: 2005

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/24605

Thesis Bench-Scale Production of Heterologous Proteins from Extremophiles- Escherichia coli and Pichia pastoris based expression systems

Ramchuran, Santosh · 2005 · Lund University (LUP) · DOI

Full title: Bench-Scale Production of Heterologous Proteins from Extremophiles- Escherichia coli and Pichia pastoris based expression systems

Authors: Ramchuran, Santosh

Year: 2005

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/544473

Thesis Perturbation-based Control of Industrial Fed-batch Bioprocesses

Johnsson, Ola · 2015 · Lund University (LUP) · DOI

Full title: Perturbation-based Control of Industrial Fed-batch Bioprocesses

Authors: Johnsson, Ola

Year: 2015

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/8412104

Thesis Probing Control in B. licheniformis Fermentations

Johnsson, Ola · 2010 · Lund University Student Papers · DOI

Full title: Probing Control in B. licheniformis Fermentations

Authors: Johnsson, Ola

Year: 2010

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/8847429

Thesis Produção de glicerol quinase em Pichia pastoris

Aizemberg, Raquel [UNESP] · 2014 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Produção de glicerol quinase em Pichia pastoris

Authors: Aizemberg, Raquel [UNESP]

Year: 2014

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://hdl.handle.net/11449/88349

Thesis Microbubble fermentation of recombinant Pichia pastoris for human serum albumin production

Zhang, Wei · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Microbubble fermentation of recombinant Pichia pastoris for human serum albumin production

Authors: Zhang, Wei

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/33395

Thesis Optimization of the production of recombinant macrophage inhibitory cytokine 1 (MIC-1) from Pichia pastoris

Pratanaphon, Ronachai · 2006 · UNSW Sydney · DOI

Full title: Optimization of the production of recombinant macrophage inhibitory cytokine 1 (MIC-1) from Pichia pastoris

Authors: Pratanaphon, Ronachai

Year: 2006

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/68401

Thesis Optimal conditions for cytochrome c production in batch and continuous culture.

Cail, Russell George · 1977 · UNSW Sydney · DOI

Full title: Optimal conditions for cytochrome c production in batch and continuous culture.

Authors: Cail, Russell George

Year: 1977

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/59746

Thesis Estratègies d’operació per a la producció de lipases de Rhizopus oryzae amb el fenotip Mut(s) de Pichia pastoris mitjançant substrats mixtes

Arnau Jiménez, Carol · 2011 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Estratègies d’operació per a la producció de lipases de Rhizopus oryzae amb el fenotip Mut(s) de Pichia pastoris mitjançant substrats mixtes

Authors: Arnau Jiménez, Carol

Year: 2011

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/42007

Thesis Model-based design and development of operational strategies for Rhizopus oryzae lipase production in Pichia pastoris under the AOX1 promoter

Barrigón de San Marcos, José Manuel · 2015 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Model-based design and development of operational strategies for Rhizopus oryzae lipase production in Pichia pastoris under the AOX1 promoter

Authors: Barrigón de San Marcos, José Manuel

Year: 2015

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/287984

Thesis Anàlisi quantitatiu de l’efecte de l’expressió d’una lipasa recombinant sobre el metabolisme central de Pichia pastoris

Jordà Murria, Joel · 2013 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Anàlisi quantitatiu de l’efecte de l’expressió d’una lipasa recombinant sobre el metabolisme central de Pichia pastoris

Authors: Jordà Murria, Joel

Year: 2013

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/117310

Thesis L’increment de la dosi gènica com a estratègia de millora de la producció de proteïnes recombinants al llevat Pichia pastoris: revertint les limitacions genètiques del sistema biològic

Cámara Rey, Elena · 2017 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: L’increment de la dosi gènica com a estratègia de millora de la producció de proteïnes recombinants al llevat Pichia pastoris: revertint les limitacions genètiques del sistema biològic

Authors: Cámara Rey, Elena

Year: 2017

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/399833

Thesis Utilización de glicerol proveniente de la industria de biodiesel como fuente de carbono para la producción de lipasas recombinantes en Pichia pastoris.

Loango Chamorro, Nelsy · 2015 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Utilización de glicerol proveniente de la industria de biodiesel como fuente de carbono para la producción de lipasas recombinantes en Pichia pastoris.

Authors: Loango Chamorro, Nelsy

Year: 2015

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/313455

Thesis Bioprocess efficiency as a roadmap to establish Pichia pastoris as a reliable cell factory

Ponte Font, Xavier · 2017 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Bioprocess efficiency as a roadmap to establish Pichia pastoris as a reliable cell factory

Authors: Ponte Font, Xavier

Year: 2017

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/457712

Thesis Overcoming the secretory limitations in Pichia pastoris for recombinant protein production

Barrero Peña, Juan José · 2021 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Overcoming the secretory limitations in Pichia pastoris for recombinant protein production

Authors: Barrero Peña, Juan José

Year: 2021

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/670387

Thesis Combining bioprocess and strain engineering strategies as efficient tools for the optimization of recombinant protein production in Pichia pastoris

Nieto Taype, Miguel Angel · 2020 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Combining bioprocess and strain engineering strategies as efficient tools for the optimization of recombinant protein production in Pichia pastoris

Authors: Nieto Taype, Miguel Angel

Year: 2020

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/670163

Thesis Developing strategies for systems metabolic engineering of Pichia pastoris

Tomàs Gamisans, Màrius · 2017 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Developing strategies for systems metabolic engineering of Pichia pastoris

Authors: Tomàs Gamisans, Màrius

Year: 2017

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/458538

Thesis Systematic metabolic analysis of recombinant Pichia pastoris under different oxygen conditions A Metabolome and Fluxome Based Study

Carnicer Heras, Marc · 2012 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Systematic metabolic analysis of recombinant Pichia pastoris under different oxygen conditions A Metabolome and Fluxome Based Study

Authors: Carnicer Heras, Marc

Year: 2012

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/96813

Thesis Increasing biomass production in bioreactors applying metabolic analysis and engineering tools

Comas Sanchez, Pere · 2021 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Increasing biomass production in bioreactors applying metabolic analysis and engineering tools

Authors: Comas Sanchez, Pere

Year: 2021

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/671074

Thesis Physiological control of Pichia pastoris for the production of recombinant proteins: A novel Respiratory Quotient control based on Artificial Intelligence and scale-up of the bioprocess

Gasset Franch, Arnau · 2024 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Physiological control of Pichia pastoris for the production of recombinant proteins: A novel Respiratory Quotient control based on Artificial Intelligence and scale-up of the bioprocess

Authors: Gasset Franch, Arnau

Year: 2024

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/691293

Thesis Biomarkers to evaluate the effects of temperature and methanol on recombinant Pichia pastoris

Farías, Jorge G · 2014 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Biomarkers to evaluate the effects of temperature and methanol on recombinant Pichia pastoris

Authors: Farías, Jorge G

Year: 2014

Venue: Universidade de São Paulo – USP Digital Library

DOI: http://www.scielo.br/pdf/bjm/v45n2/14.pdf

Thesis Expression and Mutagenesis studies of Candida antactica lipase B

Rotticci-Mulder, Johanna C. · 2003 · KTH Royal Institute of Technology · DOI

Full title: Expression and Mutagenesis studies of Candida antactica lipase B

Authors: Rotticci-Mulder, Johanna C.

Year: 2003

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3493

Thesis Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care

Cleto, Sara; Lee, Kevin; Perez-Pinera, Pablo et al. · 2017 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care

Authors: Cleto, Sara; Lee, Kevin; Perez-Pinera, Pablo; Han, Ningren; Cao, Jicong; Purcell, Oliver; Shah, Kartik A; Ram, Rajeev J; Lu, Timothy K

Year: 2017

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/109076

Thesis Fed-batch microbioreactor platform for scale down and analysis of a plasmid DNA production process

Bower, Diana Morgan; Lee, Kevin Shao-Kwan; Ram, Rajeev J et al. · 2019 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Fed-batch microbioreactor platform for scale down and analysis of a plasmid DNA production process

Authors: Bower, Diana Morgan; Lee, Kevin Shao-Kwan; Ram, Rajeev J; Prather, Kristala L

Year: 2019

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/122647

Thesis A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production

Lee, Kevin S.; Lee, Harry L. T.; Mozdzierz, Nicholas Joseph et al. · 2017 · Massachusetts Institute of Technology (MIT) · DOI

Full title: A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production

Authors: Lee, Kevin S.; Lee, Harry L. T.; Mozdzierz, Nicholas Joseph; Love, Kerry R.; Shah, Kartik A; Ram, Rajeev J; Love, John C

Year: 2017

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/109453

Thesis Macroscopic modeling of bioreactors for recombinant protein producing Pichia pastoris in defined medium

Hong, Moo Sun; Velez-Suberbie, M Lourdes; Maloney, Andrew J et al. · 2021 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Macroscopic modeling of bioreactors for recombinant protein producing Pichia pastoris in defined medium

Authors: Hong, Moo Sun; Velez-Suberbie, M Lourdes; Maloney, Andrew J; Biedermann, Andrew; Love, Kerry R; Love, J Christopher; Mukhopadhyay, Tarit K; Braatz, Richard D

Year: 2021

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/133351

Thesis Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel et al. · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Authors: Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel; Dang, Brendan; Wolffe, Lenna A; Atari, Adel; Tseng, Yuen-Yi; Love, J Christopher

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/163220

Thesis Optimal Feeding Strategy for Bioreactors with Biomass Death

Bodizs, L.; Srinivasan, B.; Bonvin, D. · 2004 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Optimal Feeding Strategy for Bioreactors with Biomass Death

Authors: Bodizs, L.; Srinivasan, B.; Bonvin, D.

Year: 2004

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/176738

Thesis Optimal Operation of Fed-Batch Fermentations via Adaptive Control of Overflow Metabolite

Valentinotti, S.; Srinivasan, B.; Holmberg, U. et al. · 2004 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Optimal Operation of Fed-Batch Fermentations via Adaptive Control of Overflow Metabolite

Authors: Valentinotti, S.; Srinivasan, B.; Holmberg, U.; Bonvin, D.; Cannizzaro, C.; Rhiel, M.; von Stockar, U.

Year: 2004

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/176209

Thesis Oxygen Control for an Industrial Pilot-Scale Fed-Batch Filamentous Fungal Fermentation

Bodizs, Levente; Titica, Mariana; Faria, Nuno et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Oxygen Control for an Industrial Pilot-Scale Fed-Batch Filamentous Fungal Fermentation

Authors: Bodizs, Levente; Titica, Mariana; Faria, Nuno; Srinivasan, Bala; Dochain, Denis; Bonvin, Dominique

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/222030

Thesis An Optimal Operating Strategy for Fed-Batch Fermentations by Feeding the Overflow Metabolite

Valentinotti, S.; Cannizzaro, C.; Srinivasan, B. et al. · 2004 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: An Optimal Operating Strategy for Fed-Batch Fermentations by Feeding the Overflow Metabolite

Authors: Valentinotti, S.; Cannizzaro, C.; Srinivasan, B.; Bonvin, D.

Year: 2004

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/176669

Thesis Extremum-Seeking Control of Industrial-Scale Fermentation Processes

Johnsson, Ola · 2013 · Lund University (LUP) · DOI

Full title: Extremum-Seeking Control of Industrial-Scale Fermentation Processes

Authors: Johnsson, Ola

Year: 2013

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/4065043

Thesis Multidisciplinary approach for recombinant protein production bioprocess design with classic and novel expression systems in Pichia pastoris

Garrigós Martínez, Javier · 2021 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Multidisciplinary approach for recombinant protein production bioprocess design with classic and novel expression systems in Pichia pastoris

Authors: Garrigós Martínez, Javier

Year: 2021

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/671119

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Metadata only

Paper Effects of temperature and glycerol and methanol‐feeding profiles on the production of recombinant galactose oxidase in Pichia pastoris

Anasontzis, George E; Penã, Margarita Salazar; Spadiut, Oliver et al. · 2014 · Biotechnology Progress · DOI

Full title: Effects of temperature and glycerol and methanol‐feeding profiles on the production of recombinant galactose oxidase in Pichia pastoris

Authors: Anasontzis, George E; Penã, Margarita Salazar; Spadiut, Oliver; Brumer, Harry; Olsson, Lisbeth

Year: 2014

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.1878

Paper Towards optimal substrate feeding for heterologous protein production in Pichia pastoris (Komagataella spp) fed‐batch processes under PAOX1 control: a modeling aided approach

Ponte, Xavier; Barrigón, José Manuel; Maurer, Michael et al. · 2018 · Journal of Chemical Technology & Biotechnology · DOI

Full title: Towards optimal substrate feeding for heterologous protein production in Pichia pastoris (Komagataella spp) fed‐batch processes under PAOX1 control: a modeling aided approach

Authors: Ponte, Xavier; Barrigón, José Manuel; Maurer, Michael; Mattanovich, Diethard; Valero, Francisco; Montesinos, José Luis González

Year: 2018

Venue: Journal of Chemical Technology & Biotechnology

DOI: https://doi.org/10.1002/jctb.5677

Paper Cloning and expression of a functional core streptavidin in Pichia pastoris: Strategies to increase yield

Casteluber, Marisa C. F.; Damasceno, Leonardo M.; Silveira, Wendel Batista da et al. · 2012 · Biotechnology Progress · DOI

Full title: Cloning and expression of a functional core streptavidin in Pichia pastoris: Strategies to increase yield

Authors: Casteluber, Marisa C. F.; Damasceno, Leonardo M.; Silveira, Wendel Batista da; Diniz, Raphael Hermano Santos; Passos, Frederico José Vieira; Passos, Flávia Maria Lopes; Passos, Flávia M. L.; Passos, Flávia M. L.

Year: 2012

Venue: Biotechnology Progress

DOI: https://doi.org/10.1002/btpr.1621

Paper Optimization of cell density and dilution rate in Pichia pastoris continuous fermentations for production of recombinant proteins

Zhang, Wenhui; Liu, Chih-Ping; İnan, Mehmet et al. · 2004 · Journal of Industrial Microbiology & Biotechnology · DOI

Full title: Optimization of cell density and dilution rate in Pichia pastoris continuous fermentations for production of recombinant proteins

Authors: Zhang, Wenhui; Liu, Chih-Ping; İnan, Mehmet; Meagher, Michael M.

Year: 2004

Venue: Journal of Industrial Microbiology & Biotechnology

DOI: https://doi.org/10.1007/s10295-004-0155-4

Paper Efficient secretion of inulin fructotransferase in Pichia pastoris using the formaldehyde dehydrogenase 1 promoter

Zhan, Rongrong; Mu, Wanmeng; Jiang, Bo et al. · 2014 · Journal of Industrial Microbiology & Biotechnology · DOI

Full title: Efficient secretion of inulin fructotransferase in Pichia pastoris using the formaldehyde dehydrogenase 1 promoter

Authors: Zhan, Rongrong; Mu, Wanmeng; Jiang, Bo; Zhou, Liuming; Zhang, Tao

Year: 2014

Venue: Journal of Industrial Microbiology & Biotechnology

DOI: https://doi.org/10.1007/s10295-014-1516-2

Paper Improved Production of Recombinant Ovine Interferon-τ by Mut+ Strain of Pichia pastoris Using an Optimized Methanol Feed Profile

Sinha, Jyoti; Plantz, Bradley A.; Zhang, Wei et al. · 2003 · Biotechnology Progress · DOI

Full title: Improved Production of Recombinant Ovine Interferon-τ by Mut+ Strain of Pichia pastoris Using an Optimized Methanol Feed Profile

Authors: Sinha, Jyoti; Plantz, Bradley A.; Zhang, Wei; Gouthro, Mark A.; Schlegel, Vicki; Liu, C.-P.; Meagher, Michael M.

Year: 2003

Venue: Biotechnology Progress

DOI: https://doi.org/10.1021/bp025744q

Paper Hybrid Deep Modeling of a GS115 (Mut+) Pichia pastoris Culture with State–Space Reduction

Pinto, José M.; Ramos, João R. C.; Costa, Rafael S. et al. · 2023 · Fermentation · DOI

Full title: Hybrid Deep Modeling of a GS115 (Mut+) Pichia pastoris Culture with State–Space Reduction

Authors: Pinto, José M.; Ramos, João R. C.; Costa, Rafael S.; Oliveira, Rui

Year: 2023

Venue: Fermentation

DOI: https://doi.org/10.3390/fermentation9070643

Paper Enhancing Antimicrobial Peptide Productivity in Pichia pastoris (Muts Strain) by Improving the Fermentation Process Based on Increasing the Volumetric Methanol Consumption Rate

Kongsinkaew, Chatchol; Chittapun, Supenya; Piyapittayanun, Chanitchote et al. · 2023 · Fermentation · DOI

Full title: Enhancing Antimicrobial Peptide Productivity in Pichia pastoris (Muts Strain) by Improving the Fermentation Process Based on Increasing the Volumetric Methanol Consumption Rate

Authors: Kongsinkaew, Chatchol; Chittapun, Supenya; Piyapittayanun, Chanitchote; Boonyaratanakornkit, Viroj; Sooksai, Sarintip; Ajariyakhajorn, Kittisak; Pornpukdeewattana, Soisuda; Krusong, Warawut; Laemthong, Tunyaboon; Charoenrat, Theppanya

Year: 2023

Venue: Fermentation

DOI: https://doi.org/10.3390/fermentation9030277

Paper Production and Purification of Soy Leghemoglobin from Pichia pastoris Cultivated in Different Expression Media

Bolmanis, Emīls; Bogans, Jānis; Akopjana, Ināra et al. · 2023 · Processes · DOI

Full title: Production and Purification of Soy Leghemoglobin from Pichia pastoris Cultivated in Different Expression Media

Authors: Bolmanis, Emīls; Bogans, Jānis; Akopjana, Ināra; Šuleiko, Artūrs; Kazaka, Tatjana; Kazāks, Andris

Year: 2023

Venue: Processes

DOI: https://doi.org/10.3390/pr11113215

Paper On-line methanol sensor system development for recombinant human serum albumin production by Pichia pastoris

Panchiga, Chongchittapiban; Jӧrgen, Borg; Waiprib, Yaowapha et al. · 2016 · AFRICAN JOURNAL OF BIOTECHNOLOGY · DOI

Full title: On-line methanol sensor system development for recombinant human serum albumin production by Pichia pastoris

Authors: Panchiga, Chongchittapiban; Jӧrgen, Borg; Waiprib, Yaowapha; Jindarat, Pimsamarn; Anan, Tongta

Year: 2016

Venue: AFRICAN JOURNAL OF BIOTECHNOLOGY

DOI: https://doi.org/10.5897/ajb2015.15122

Paper Differential Expression of Laccase Genes inPleurotus ostreatusand Biochemical Characterization of Laccase Isozymes Produced inPichia pastoris

Park, Minsa; Kim, Minseek; Kim, Sinil et al. · 2015 · Mycobiology · DOI

Full title: Differential Expression of Laccase Genes inPleurotus ostreatusand Biochemical Characterization of Laccase Isozymes Produced inPichia pastoris

Authors: Park, Minsa; Kim, Minseek; Kim, Sinil; Ha, Byeongsuk; Ro, Hyeon‐Su

Year: 2015

Venue: Mycobiology

DOI: https://doi.org/10.5941/myco.2015.43.3.280

Paper Applied Microbiology 2016- Pichia process optimization by methanol/sorbitol co-feeding Ã¢Â€Â“ Patrick Fickers - University of Liege

Fickers, Patrick · 2020 · Journal of Applied Microbiology and Biochemistry

Full title: Applied Microbiology 2016- Pichia process optimization by methanol/sorbitol co-feeding Ã¢Â€Â“ Patrick Fickers - University of Liege

Authors: Fickers, Patrick

Year: 2020

Venue: Journal of Applied Microbiology and Biochemistry

Paper Cell functional enviromics: applications to Pichia pastoris

Isidro, Inês A. · 2015 · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Full title: Cell functional enviromics: applications to Pichia pastoris

Authors: Isidro, Inês A.

Year: 2015

Venue: Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Paper Bioprocess efficiency as a roadmap to establish Pichia pastoris as a reliable cell factory

Ponce, Javier · 2017 · Dialnet (Universidad de la Rioja)

Full title: Bioprocess efficiency as a roadmap to establish Pichia pastoris as a reliable cell factory

Authors: Ponce, Javier

Year: 2017

Venue: Dialnet (Universidad de la Rioja)

Paper Development of Pichia pastoris as a production system for HPV16 L1 virus-like particles as component to a subunit vaccine

Kotze, Lara · 2007 · SUNScholar (Stellenbosch University)

Full title: Development of Pichia pastoris as a production system for HPV16 L1 virus-like particles as component to a subunit vaccine

Authors: Kotze, Lara

Year: 2007

Venue: SUNScholar (Stellenbosch University)

Paper Novel Bifunctional Single-Chain Variable Antibody Fragments to Enhance Virolysis by Complement: Generation and Proof-of-Concept

Huber, G. Carl; Bánki, Zoltán; Kunert, Renate et al. · 2014 · BioMed Research International · DOI

Full title: Novel Bifunctional Single-Chain Variable Antibody Fragments to Enhance Virolysis by Complement: Generation and Proof-of-Concept

Authors: Huber, G. Carl; Bánki, Zoltán; Kunert, Renate; Stoiber, Heribert

Year: 2014

Venue: BioMed Research International

DOI: https://doi.org/10.1155/2014/971345

Paper Evaluating Pulses and Modified Fed-batch Feeding of Methanol to Increase Expression Level of Human Insulin Precursor in Pichia Pastoris High-Density Cultivation

Putro, Eko Wahyu; Nurdiani, Dini; Hariyatun et al. · 2022 · International Journal on Advanced Science Engineering and Information Technology · DOI

Full title: Evaluating Pulses and Modified Fed-batch Feeding of Methanol to Increase Expression Level of Human Insulin Precursor in Pichia Pastoris High-Density Cultivation

Authors: Putro, Eko Wahyu; Nurdiani, Dini; Hariyatun; Utami, Nuruliawaty; Kusharyoto, Wien; Juanssilfero, Ario Betha; Silvia, Rozy Ayu

Year: 2022

Venue: International Journal on Advanced Science Engineering and Information Technology

DOI: https://doi.org/10.18517/ijaseit.12.3.15109

Paper Integrating data-driven strategies into model predictive control for enhanced production of human interferon α2b in glycoengineered Pichia pastoris

Pavan, Satya Sai; Solanki, Shikha; Sivaprakasam, Senthilkumar · 2025 · DOI

Full title: Integrating data-driven strategies into model predictive control for enhanced production of human interferon α2b in glycoengineered Pichia pastoris

Authors: Pavan, Satya Sai; Solanki, Shikha; Sivaprakasam, Senthilkumar

Year: 2025

DOI: https://doi.org/10.21203/rs.3.rs-6707781/v1

Paper Implementing Chemostat Fermentation of Pichia Pastoris Producing Recombinant HBsAg to Optimize Cell Density Affected by Methanol Rate

Rahimi, Alireza; Karimi, Afzal; Hosseini, Seyed Mohammad et al. · 2021 · Biointerface Research in Applied Chemistry · DOI

Full title: Implementing Chemostat Fermentation of Pichia Pastoris Producing Recombinant HBsAg to Optimize Cell Density Affected by Methanol Rate

Authors: Rahimi, Alireza; Karimi, Afzal; Hosseini, Seyed Mohammad; Aghdasinia, Hassan; Mianroodi, Reza Arabi; Nieto-Taype, M; Garcia-Ortega, X; Albiol, J; Montesinos-Segu, J; Valero, F; Muoz, M; Rincn, J Juregui; Carren, L; Vela, N; Karbalaei, M; Rezaee, S; Farsiani, H; Rahimi, A; Hosseini, S; Javidanbardan, A; Khatami, M; Rahimi, A; Hosseini, S; Karimi, A; Aghdasinia, H; Mianroodi, R Arabi; Hosseini, S; Javidanbardan, A; Khatami, M; Tripathi, N; Shrivastava, A; Oak, A; Jansen, G; Chan, C; Cregg, J; Cereghino, J; Shi, J; Higgins, D; Cos, O; Ramn, R; Montesinos, J; Valero, F; James, A; Morvarid, A; Zeenathul, N; Tam, Y; Zuridah, H; Mohd-Azmi, M; Azizon, B; Gurramkonda, C; Adnan, A; Gbel, T; Lnsdorf, H; Ross, A; Nemani, S; Swaminathan, S; Khanna, N; Rinas, U; Cereghino, G; Cereghino, J; Ilgen, C; Cregg, J; Julien, C; Singh, A; Narang, A; Takagi, S; Tsutsumi, N; Terui, Y; Kong, X; Yurimoto, H; Sakai, Y; Hardy, E; Martnez, E; Diago, D; Daz, R; Gonzlez, D; Herrera, L; Hosseini, S; Sarvari, T; Bashiri, G; Khatami, M; Shojaosadati, S; Yazdani, R; Shams-Bakhsh, M; Hassani-Mehraban, A; Arab, S; Thelen, N; Thiry, M; Crommen, J; Fillet, M; Jacobs, N; Brans, A; Servais, A.-C; Tam, Y; Allaudin, Z; Lila, M; Bahaman, A; Tan, J; Rezaei, M; Chauhan, A

Year: 2021

Venue: Biointerface Research in Applied Chemistry

DOI: https://doi.org/10.33263/briac115.1263312641

Paper Optimizing Yeast Surface-Displayed Unspecific Peroxygenase Production for Sustainable Biocatalysis

Teetz, Niklas; Zuhse, Luc; Holtmann, Dirk · 2025 · Bioengineering · DOI

Full title: Optimizing Yeast Surface-Displayed Unspecific Peroxygenase Production for Sustainable Biocatalysis

Authors: Teetz, Niklas; Zuhse, Luc; Holtmann, Dirk

Year: 2025

Venue: Bioengineering

DOI: https://doi.org/10.3390/bioengineering12080822

Thesis Expression of functional human sialyltransferases ST6GalNAc5 and ST6GalNAc6 in Pichia pastoris

Krasnoselska, Ganna; Lengyel, Marton; Matwiejuk, Martin et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Expression of functional human sialyltransferases ST6GalNAc5 and ST6GalNAc6 in Pichia pastoris

Authors: Krasnoselska, Ganna; Lengyel, Marton; Matwiejuk, Martin; Vuillemin, Marlene; Molnar-Gabor, Dora; Meyer, Anne S; id_orcid 0000-0001-8910-9931; Zeuner, Birgitte; id_orcid 0000-0002-8593-6742

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b964f139-ec97-4ba6-96db-65ed780e6fdc

Thesis Applying an MPC algorithm to the dissolved oxygen level of an intermittent fed-batch process

Pably, P.; Huusom, J. K.; id_orcid 0000-0002-1367-7235 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Applying an MPC algorithm to the dissolved oxygen level of an intermittent fed-batch process

Authors: Pably, P.; Huusom, J. K.; id_orcid 0000-0002-1367-7235; Kager, J.; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e5bf89bb-2803-4e21-a9e6-46f1fe8b45c3

Thesis Produção de glycerol quinase recombinante utilizando o sistema Pichia pastoris

Terrazas, Werner Damião Morhy; Aizemberg, Raquel [UNESP]; Gattás, Edwil Aparecida de Lucca [UNESP] · 2018 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Produção de glycerol quinase recombinante utilizando o sistema Pichia pastoris

Authors: Terrazas, Werner Damião Morhy; Aizemberg, Raquel [UNESP]; Gattás, Edwil Aparecida de Lucca [UNESP]

Year: 2018

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://hdl.handle.net/11449/177286

Thesis Fed-batch production of the hydrophobins RodA and RodB from Aspergillus fumigatus in host Pichia pastoris

Pedersen, Mona Højgaard; Borodina, Irina; Frisvad, Jens Christian et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: Fed-batch production of the hydrophobins RodA and RodB from Aspergillus fumigatus in host Pichia pastoris

Authors: Pedersen, Mona Højgaard; Borodina, Irina; Frisvad, Jens Christian; id_orcid 0000-0002-0573-4340; Søndergaard, Ib

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/67337f0c-b465-4be1-8fb6-4b32cb6311c5

Thesis Potential of predictive model-based dissolved oxygen control for intermittent fed-batch processes

Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235 et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Potential of predictive model-based dissolved oxygen control for intermittent fed-batch processes

Authors: Pably, Philipp; Huusom, Jakob K.; id_orcid 0000-0002-1367-7235; Kager, Julian; id_orcid 0000-0001-7274-6678

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/672b1410-685c-430d-9a82-cd4a33c61d66

Thesis Using Pichia pastoris to produce recombinant glycerol kinase

Terrazas, Werner Damião Morhy; Aizemberg, Raquel [UNESP]; Gattas, Edwil Aparecida de Lucca [UNESP] · 2016 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Using Pichia pastoris to produce recombinant glycerol kinase

Authors: Terrazas, Werner Damião Morhy; Aizemberg, Raquel [UNESP]; Gattas, Edwil Aparecida de Lucca [UNESP]

Year: 2016

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/3143

Thesis Recombinant laccase biosynthesis for efficient polydopamine coating

Magalhães, Flávia F.; Neves, Márcia C.; Pedro, Augusto Q. et al. · 2025 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Recombinant laccase biosynthesis for efficient polydopamine coating

Authors: Magalhães, Flávia F.; Neves, Márcia C.; Pedro, Augusto Q.; Freire, Mara G.; Santos-Ebinuma, Valéria C. [UNESP]; Tavares, Ana P.M.

Year: 2025

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1016/j.bej.2024.109483

Thesis Recombinant laccase biosynthesis for efficient polydopamine coating

Magalhães, Flávia F.; Neves, Márcia C.; Pedro, Augusto Q. et al. · 2025 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Recombinant laccase biosynthesis for efficient polydopamine coating

Authors: Magalhães, Flávia F.; Neves, Márcia C.; Pedro, Augusto Q.; Freire, Mara G.; Santos-Ebinuma, Valéria C. [UNESP]; Tavares, Ana P.M.

Year: 2025

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1016/j.bej.2024.109483

Thesis High-Level Expression of a Functional Humanized Anti-CTLA4 Single-Chain Variable Fragment Antibody in Pichia Pastoris

Cai, Huawei; Chen, Lihong; Wan, Lin et al. · 2009 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: High-Level Expression of a Functional Humanized Anti-CTLA4 Single-Chain Variable Fragment Antibody in Pichia Pastoris

Authors: Cai, Huawei; Chen, Lihong; Wan, Lin; Zeng, Lingyu; Yang, Hao; Li, Shengfu; Li, Youping; Cheng, Jingqiu; Lu, Xiaofeng

Year: 2009

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-17754

Thesis Estudio de la producción heteróloga de una lipasa del hongo Rhizopus oryzae en la levadura metilotrófica Pichia pastoris

Serrano Gonzàlez, Alícia · 2011 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Estudio de la producción heteróloga de una lipasa del hongo Rhizopus oryzae en la levadura metilotrófica Pichia pastoris

Authors: Serrano Gonzàlez, Alícia

Year: 2011

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://www.tdx.cat/TDX-0701104-165829

Thesis Millora en el procés de producció d'una lipasa de Rhizopus oryzae en Pichia pastoris mitjançant tècniques de monitoratge i estratègies de cultiu alternatives

Surribas i Casalprim, Anna · 2011 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Millora en el procés de producció d'una lipasa de Rhizopus oryzae en Pichia pastoris mitjançant tècniques de monitoratge i estratègies de cultiu alternatives

Authors: Surribas i Casalprim, Anna

Year: 2011

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://www.tdx.cat/TDX-0217110-131258

Thesis Monitorització i control del procés de producció de proteïnes heteròlogues en el llevat metilotròfic Pichia Pastoris

Cos Busquets, Oriol · 2011 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Monitorització i control del procés de producció de proteïnes heteròlogues en el llevat metilotròfic Pichia Pastoris

Authors: Cos Busquets, Oriol

Year: 2011

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://www.tdx.cat/TDX-0313106-175720

Thesis Doubling humanized L-asparaginase expression by Pichia pastoris through DO-stat controlling induction strategy in bench-bioreactor

Tonso, Aldo · 2019 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Doubling humanized L-asparaginase expression by Pichia pastoris through DO-stat controlling induction strategy in bench-bioreactor

Authors: Tonso, Aldo

Year: 2019

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://www.aidic.it/ecce12/programma/1535parizotto.docx

Thesis Transcriptomic insights into methanol utilization in Pichia pastoris lacking AOX genes under co-feeding conditions

Zheng, Xueyun; Ye, Zhifang; Gao, Jiao et al. · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Transcriptomic insights into methanol utilization in Pichia pastoris lacking AOX genes under co-feeding conditions

Authors: Zheng, Xueyun; Ye, Zhifang; Gao, Jiao; Hao, Yuechuo; Li, Cheng; Xie, Hongsen; Lin, Ying; Liang, Shuli

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/159262

Thesis Influence of specific growth rate on specific productivity and glycosylation of a recombinant avidin produced by a Pichia pastoris Mut(+) strain

Schenk, Jonas; Balazs, Krisztina; Jungo, Carmen et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Influence of specific growth rate on specific productivity and glycosylation of a recombinant avidin produced by a Pichia pastoris Mut(+) strain

Authors: Schenk, Jonas; Balazs, Krisztina; Jungo, Carmen; Urfer, Julien; Wegmann, Carole; Zocchi, Andrea; Marison, Ian W.; von Stockar, Urs

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/58381

Patent us-2010112639-a1

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Full title: us-2010112639-a1

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Patent us-2014287459-a1

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Full title: us-2014287459-a1

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Patent us-2016039911-a1

· 2016

Full title: us-2016039911-a1

Year: 2016

Patent us-2004091954-a1

· 2004

Full title: us-2004091954-a1

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Patent us-2005202525-a1

· 2005

Full title: us-2005202525-a1

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Patent us-2010028942-a1

· 2010

Full title: us-2010028942-a1

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Patent us-5102789-a

· 1992

Full title: us-5102789-a

Year: 1992

Patent us-6955892-b2

· 2005

Full title: us-6955892-b2

Year: 2005

Patent us-7521203-b2

· 2009

Full title: us-7521203-b2

Year: 2009

2. Data Extraction

0/178 extracted

Paper

Investigating the physiological response of Pichia (Komagataella) pastoris GS115 to the heterologous expression of misfolded proteins using chemostat cultures

Hesketh, Andrew; Castrillo, Juan I.; Sawyer, Trevor et al. · 2013

Full title: Investigating the physiological response of Pichia (Komagataella) pastoris GS115 to the heterologous expression of misfolded proteins using chemostat cultures

Authors: Hesketh, Andrew; Castrillo, Juan I.; Sawyer, Trevor; Archer, David B.; Oliver, Stephen G.

DOI: https://doi.org/10.1007/s00253-013-5186-1

Paper

Expression of functional human sialyltransferases ST6GalNAc5 and ST6GalNAc6 in Pichia pastoris

Krasnoselska, Ganna O.; Lengyel, Márton; Matwiejuk, Martin et al. · 2025

Full title: Expression of functional human sialyltransferases ST6GalNAc5 and ST6GalNAc6 in Pichia pastoris

Authors: Krasnoselska, Ganna O.; Lengyel, Márton; Matwiejuk, Martin; Vuillemin, M. Paul; Molnár-Gábor, Dóra; Meyer, Anne S.; Zeuner, Birgitte

DOI: https://doi.org/10.1007/s00253-025-13607-x

Paper

Production and secretion dynamics of prokaryotic Penicillin G acylase in Pichia pastoris

Borčinová, Martina; Raschmanová, Hana; Zamora, Iwo et al. · 2020

Full title: Production and secretion dynamics of prokaryotic Penicillin G acylase in Pichia pastoris

Authors: Borčinová, Martina; Raschmanová, Hana; Zamora, Iwo; Looser, Verena; Marešová, Helena; Hirsch, Sven; Kyslı́k, Pavel; Kovar, Karin

DOI: https://doi.org/10.1007/s00253-020-10669-x

Paper

Methanol feeding strategies for high-yield production of a collagen-based protein in Komagataella phaffii

Ebbecke, Jan Peter; Schlauch, Domenic; Güler, Cengiz et al. · 2025

Full title: Methanol feeding strategies for high-yield production of a collagen-based protein in Komagataella phaffii

Authors: Ebbecke, Jan Peter; Schlauch, Domenic; Güler, Cengiz; Pirmahboub, Hamidreza; Kara, Selin; Pepelanova, Iliyana

DOI: https://doi.org/10.1007/s00253-025-13675-z

Paper

Real-time estimation of biomass and specific growth rate in physiologically variable recombinant fed-batch processes

Wechselberger, Patrick; Sagmeister, Patrick; Herwig, Christoph · 2012

Full title: Real-time estimation of biomass and specific growth rate in physiologically variable recombinant fed-batch processes

Authors: Wechselberger, Patrick; Sagmeister, Patrick; Herwig, Christoph

DOI: https://doi.org/10.1007/s00449-012-0848-4

Paper

High-level expression of biologically active glycoprotein hormones in Pichia pastoris strains—selection of strain GS115, and not X-33, for the production of biologically active N-glycosylated 15N-labeled phCG

Blanchard, Véronique; Gadkari, Rupali A.; George, A. V. E. et al. · 2008

Authors: Blanchard, Véronique; Gadkari, Rupali A.; George, A. V. E.; Roy, Satarupa Sinha; Gerwig, Gerrit J.; Leeflang, Bas R.; Dighe, Rajan R.; Boelens, Rolf; Kamerling, Johannis P.

DOI: https://doi.org/10.1007/s10719-007-9082-8

Paper

Structural and functional comparison of SARS-CoV-2-spike receptor binding domain produced in Pichia pastoris and mammalian cells

Arbeitman, Claudia R.; Auge, Gabriela; Blaustein, Matı́as et al. · 2020

Full title: Structural and functional comparison of SARS-CoV-2-spike receptor binding domain produced in Pichia pastoris and mammalian cells

DOI: https://doi.org/10.1038/s41598-020-78711-6

Paper

Enhanced cell density cultivation and rapid expression-screening of recombinant Pichia pastoris clones in microscale

Kaushik, Neha; Lamminmäki, Urpo; Khanna, Navin et al. · 2020

Full title: Enhanced cell density cultivation and rapid expression-screening of recombinant Pichia pastoris clones in microscale

Authors: Kaushik, Neha; Lamminmäki, Urpo; Khanna, Navin; Batra, Gaurav

DOI: https://doi.org/10.1038/s41598-020-63995-5

Paper

Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care

Pérez‐Piñera, Pablo; Han, Ningren; Cleto, Sara et al. · 2016

Full title: Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care

Authors: Pérez‐Piñera, Pablo; Han, Ningren; Cleto, Sara; Cao, Jicong; Purcell, Oliver; Shah, Kartik; Lee, Kevin; Ram, Rajeev J.; Lu, Timothy K.

DOI: https://doi.org/10.1038/ncomms12211

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Improvement of a fermentation process for the production of two PfAMA1-DiCo-based malaria vaccine candidates in Pichia pastoris

Kastilan, Robin; Boes, Alexander; Spiegel, Holger et al. · 2017

Full title: Improvement of a fermentation process for the production of two PfAMA1-DiCo-based malaria vaccine candidates in Pichia pastoris

Authors: Kastilan, Robin; Boes, Alexander; Spiegel, Holger; Voepel, Nadja; Chudobová, Ivana; Hellwig, Stephan; Buyel, Johannes F.; Reimann, Andreas; Fischer, Rainer

DOI: https://doi.org/10.1038/s41598-017-11819-4

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Scaling-up Fermentation of Pichia pastoris to demonstration-scale using new methanol-feeding strategy and increased air pressure instead of pure oxygen supplement

Liu, Wan-Cang; Gong, Ting; Wang, Qinghua et al. · 2016

Full title: Scaling-up Fermentation of Pichia pastoris to demonstration-scale using new methanol-feeding strategy and increased air pressure instead of pure oxygen supplement

Authors: Liu, Wan-Cang; Gong, Ting; Wang, Qinghua; Liang, Xiao; Chen, Jingjing; Zhu, Ping

DOI: https://doi.org/10.1038/srep18439

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Increased dosage of AOX1 promoter-regulated expression cassettes leads to transcription attenuation of the methanol metabolism in Pichia pastoris

Cámara, Elena; Landes, Nils; Albiol, Joan et al. · 2017

Full title: Increased dosage of AOX1 promoter-regulated expression cassettes leads to transcription attenuation of the methanol metabolism in Pichia pastoris

Authors: Cámara, Elena; Landes, Nils; Albiol, Joan; Gasser, Brigitte; Mattanovich, Diethard; Ferrer, Pau

DOI: https://doi.org/10.1038/srep44302

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Efficient production of itaconic acid from the single carbon substrate methanol with engineered Komagataella phaffii

Severinsen, Manja Mølgaard; Bachleitner, Simone; Modenese, Viola et al. · 2024

Full title: Efficient production of itaconic acid from the single carbon substrate methanol with engineered Komagataella phaffii

Authors: Severinsen, Manja Mølgaard; Bachleitner, Simone; Modenese, Viola; Ata, Özge; Mattanovich, Diethard

DOI: https://doi.org/10.1186/s13068-024-02541-1

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Optimizing expression of Nanobody ® molecules in Pichia pastoris through co-expression of auxiliary proteins under methanol and methanol-free conditions

Groeve, Manu De; Laukens, Bram; Schotte, Peter · 2023

Full title: Optimizing expression of Nanobody ® molecules in Pichia pastoris through co-expression of auxiliary proteins under methanol and methanol-free conditions

Authors: Groeve, Manu De; Laukens, Bram; Schotte, Peter

DOI: https://doi.org/10.1101/2023.03.31.535029

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Heterologe Expression von Enzymen aus Basidiomyceten in Pichia pastoris

Kelle, Sebastian · 2015

Full title: Heterologe Expression von Enzymen aus Basidiomyceten in Pichia pastoris

Authors: Kelle, Sebastian

DOI: https://doi.org/10.15488/8487

Paper

Design and development of Pichia pastoris based dengue specific virus-like particles concerted with insights into stress responses during expression using a proteomic approach

Nemani, Satish Kumar · 2015

Full title: Design and development of Pichia pastoris based dengue specific virus-like particles concerted with insights into stress responses during expression using a proteomic approach

Authors: Nemani, Satish Kumar

DOI: https://doi.org/10.15488/8540

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Metabolic and Process Engineering of Pichia Pastoris for the Production of Value-added Products

Yang, Zhiliang · 2017

Full title: Metabolic and Process Engineering of Pichia Pastoris for the Production of Value-added Products

Authors: Yang, Zhiliang

DOI: https://doi.org/10.20381/ruor-21286

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Continuous Cultivation as a Tool Toward the Rational Bioprocess Development With Pichia Pastoris Cell Factory

Nieto‐Taype, Miguel Angel; Garcia‐Ortega, Xavier; Albiol, Joan et al. · 2020

Full title: Continuous Cultivation as a Tool Toward the Rational Bioprocess Development With Pichia Pastoris Cell Factory

Authors: Nieto‐Taype, Miguel Angel; Garcia‐Ortega, Xavier; Albiol, Joan; Montesinos, José Luis González; Valero, Francisco

DOI: https://doi.org/10.3389/fbioe.2020.00632

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Interval and Possibilistic Methods for Constraint-Based Metabolic Models

Estrada, Francisco Llaneras · 2011

Full title: Interval and Possibilistic Methods for Constraint-Based Metabolic Models

Authors: Estrada, Francisco Llaneras

DOI: https://doi.org/10.4995/thesis/10251/10528

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Different approaches to make Pichia pastoris a more versatile expression platform - process, strain and product engineering

Capone, Simona · 2016

Full title: Different approaches to make Pichia pastoris a more versatile expression platform - process, strain and product engineering

Authors: Capone, Simona

DOI: https://doi.org/10.34726/hss.2015.34046

Paper

Quantitative characterization of a recombinant Pichia pastoris Mut+ strain secreting avidin using transient continuous cultures

Jungo, Carmen · 2007

Full title: Quantitative characterization of a recombinant Pichia pastoris Mut+ strain secreting avidin using transient continuous cultures

Authors: Jungo, Carmen

DOI: https://doi.org/10.5075/epfl-thesis-3794

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Design of an optimised fed-batch process for insulin precursor production in Pichia pastoris

Bhardwaj, Vinayak · 2011

Full title: Design of an optimised fed-batch process for insulin precursor production in Pichia pastoris

Authors: Bhardwaj, Vinayak

Paper

Transforming growth factor-Ø in osteoarthritis : the good, the bad or the ugly

Scharstuhl, Alwin · 2003

Full title: Transforming growth factor-Ø in osteoarthritis : the good, the bad or the ugly

Authors: Scharstuhl, Alwin

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Upscale of recombinant α-L-rhamnosidase production by Pichia pastoris MutS strain

Markošová, Kristína; Weignerová, Lenka; Rosenberg, Michal et al. · 2015

Full title: Upscale of recombinant α-L-rhamnosidase production by Pichia pastoris MutS strain

Authors: Markošová, Kristína; Weignerová, Lenka; Rosenberg, Michal; Křen, Vladimı́r; Rebroš, Martin

DOI: https://doi.org/10.3389/fmicb.2015.01140

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Development of a New High-Cell Density Fermentation Strategy for Enhanced Production of a Fungus β-Glucosidase in Pichia pastoris

Liu, Wan-Cang; Xiang, Haibo; Zhang, Tao et al. · 2020

Full title: Development of a New High-Cell Density Fermentation Strategy for Enhanced Production of a Fungus β-Glucosidase in Pichia pastoris

Authors: Liu, Wan-Cang; Xiang, Haibo; Zhang, Tao; Pang, Xu; Su, Jing; Liu, Hongyu; Ma, Baiping; Yu, Liyan

DOI: https://doi.org/10.3389/fmicb.2020.01988

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Medium Optimization for Recombinant Human Papillomavirus Type 52 L1 Protein Production in Pichia pastoris GS115 Platform on Bioreactor Scale

Mustopa, Apon Zaenal; Amani, Firouz; Irawan, Herman et al. · 2025

Full title: Medium Optimization for Recombinant Human Papillomavirus Type 52 L1 Protein Production in Pichia pastoris GS115 Platform on Bioreactor Scale

DOI: https://doi.org/10.4308/hjb.32.5.1283-1294

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Enhancement in Human Insulin Precursor Secretion by Pichia pastoris through Modification of Expression Conditions

Nurdiani, Dini; Hariyatun, Hariyatun; Utami, Nuruliawaty et al. · 2021

Full title: Enhancement in Human Insulin Precursor Secretion by Pichia pastoris through Modification of Expression Conditions

Authors: Nurdiani, Dini; Hariyatun, Hariyatun; Utami, Nuruliawaty; Putro, Eko Wahyu; Kusharyoto, Wien

DOI: https://doi.org/10.4308/hjb.29.1.22-30

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Heterologous expression of Cysteine Protease 8 from Trichomonas foetus in Pichia pastoris

Geethanjali, Karli; Rathnagiri, Polavarapu; Kalarani, V. · 2023

Full title: Heterologous expression of Cysteine Protease 8 from Trichomonas foetus in Pichia pastoris

Authors: Geethanjali, Karli; Rathnagiri, Polavarapu; Kalarani, V.

DOI: https://doi.org/10.51966/jvas.2023.54.1.13-20

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Microbioreactors and Perfusion Bioreactors for Microbial and Mammalian Cell Culture

Ravindran, Selvan; Singh, Pooja; Nene, Sanjay et al. · 2019

Full title: Microbioreactors and Perfusion Bioreactors for Microbial and Mammalian Cell Culture

Authors: Ravindran, Selvan; Singh, Pooja; Nene, Sanjay; Rale, Vinay; Mhetras, Nutan; Vaidya, Anuradha

DOI: https://doi.org/10.5772/intechopen.83825

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Bioprocess Engineering of Pichia pastoris, an Exciting Host Eukaryotic Cell Expression System

Valero, Francisco · 2013

Full title: Bioprocess Engineering of Pichia pastoris, an Exciting Host Eukaryotic Cell Expression System

Authors: Valero, Francisco

DOI: https://doi.org/10.5772/56407

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Co-feeding strategy to enhance phytase production in Pichia pastoris

Ndayambaje, Jean Bernard; Meenakshisundaram, S. · 2014

Full title: Co-feeding strategy to enhance phytase production in Pichia pastoris

Authors: Ndayambaje, Jean Bernard; Meenakshisundaram, S.

DOI: https://doi.org/10.5897/ajb2013.12986

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Molecular characterization and expression of H5, N1 and NS1 recombinant proteins of avian influenza virus subtype H5N1 in Pichia pastoris

Abubakar, Mustapha B. · 2011

Full title: Molecular characterization and expression of H5, N1 and NS1 recombinant proteins of avian influenza virus subtype H5N1 in Pichia pastoris

Authors: Abubakar, Mustapha B.

Paper

Optimization of glutathione production in batch and fed-batch cultures by the wild-type and recombinant strains of the methylotrophic yeast Hansenula polymorphaDL-1

Ubiyvovk, Vira M.; Ananin, Vladimir; Malyshev, Alexander Y et al. · 2011

Full title: Optimization of glutathione production in batch and fed-batch cultures by the wild-type and recombinant strains of the methylotrophic yeast Hansenula polymorphaDL-1

Authors: Ubiyvovk, Vira M.; Ananin, Vladimir; Malyshev, Alexander Y; Kang, Hyun Ah; Sibirny, Andriy А.

DOI: https://doi.org/10.1186/1472-6750-11-8

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Functional expression of a blood tolerant laccase in Pichia pastoris

Maté, Diana M.; González-Pérez, David; Kittl, Roman et al. · 2013

Full title: Functional expression of a blood tolerant laccase in Pichia pastoris

Authors: Maté, Diana M.; González-Pérez, David; Kittl, Roman; Ludwig, Roland; Alcalde, Miguel

DOI: https://doi.org/10.1186/1472-6750-13-38

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Improved production of human type II procollagen in the yeast Pichia pastoris in shake flasks by a wireless-controlled fed-batch system

Ruottinen, Maria; Bollók, Mónika; Kögler, Martin et al. · 2008

Full title: Improved production of human type II procollagen in the yeast Pichia pastoris in shake flasks by a wireless-controlled fed-batch system

Authors: Ruottinen, Maria; Bollók, Mónika; Kögler, Martin; Neubauer, Antje; Krause, Mirja; Hämäläinen, Eija‐Riitta; Myllyharju, Johanna; Vasala, Antti; Neubauer, Peter

DOI: https://doi.org/10.1186/1472-6750-8-33

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A quantitative study of methanol/sorbitol co-feeding process of a Pichia pastoris Mut+/pAOX1-lacZ strain

Niu, Hongxing; Jost, Laurent; Pirlot, Nathalie et al. · 2013

Full title: A quantitative study of methanol/sorbitol co-feeding process of a Pichia pastoris Mut+/pAOX1-lacZ strain

Authors: Niu, Hongxing; Jost, Laurent; Pirlot, Nathalie; Sassi, Hosni; Daukandt, Marc; Rodriguez, Christian; Fickers, Patrick

DOI: https://doi.org/10.1186/1475-2859-12-33

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Heterologous expression of leader-less pga gene in Pichia pastoris: intracellular production of prokaryotic enzyme

Marešová, Helena; Marková, Zdena; Valešová, Renáta et al. · 2010

Full title: Heterologous expression of leader-less pga gene in Pichia pastoris: intracellular production of prokaryotic enzyme

Authors: Marešová, Helena; Marková, Zdena; Valešová, Renáta; Sklenář, Jan; Kyslı́k, Pavel

DOI: https://doi.org/10.1186/1472-6750-10-7

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Expression of recombinant staphylokinase in the methylotrophic yeast Hansenula polymorpha

Moussa, Manal Hassan; Ibrahim, Mahmoud M.; Ghazaly, Maria El et al. · 2012

Full title: Expression of recombinant staphylokinase in the methylotrophic yeast Hansenula polymorpha

Authors: Moussa, Manal Hassan; Ibrahim, Mahmoud M.; Ghazaly, Maria El; Rohde, Jan; Gnoth, Stefan; Anton, Andreas; Kensy, Frank; Müeller, Frank

DOI: https://doi.org/10.1186/1472-6750-12-96

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A dynamic method based on the specific substrate uptake rate to set up a feeding strategy for Pichia pastoris

Dietzsch, Christian; Spadiut, Oliver; Herwig, Christoph · 2011

Full title: A dynamic method based on the specific substrate uptake rate to set up a feeding strategy for Pichia pastoris

Authors: Dietzsch, Christian; Spadiut, Oliver; Herwig, Christoph

DOI: https://doi.org/10.1186/1475-2859-10-14

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Heterologous overexpression of Glomerella cingulata FAD-dependent glucose dehydrogenase in Escherichia coli and Pichia pastoris

Sygmund, Christoph; Staudigl, Petra; Klausberger, Miriam et al. · 2011

Full title: Heterologous overexpression of Glomerella cingulata FAD-dependent glucose dehydrogenase in Escherichia coli and Pichia pastoris

Authors: Sygmund, Christoph; Staudigl, Petra; Klausberger, Miriam; Pinotsis, Nikos; Djinović‐Carugo, Kristina; Gorton, Lo; Haltrich, Dietmar; Ludwig, Roland

DOI: https://doi.org/10.1186/1475-2859-10-106

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A fast approach to determine a fed batch feeding profile for recombinant Pichia pastoris strains

Dietzsch, Christian; Spadiut, Oliver; Herwig, Christoph · 2011

Full title: A fast approach to determine a fed batch feeding profile for recombinant Pichia pastoris strains

Authors: Dietzsch, Christian; Spadiut, Oliver; Herwig, Christoph

DOI: https://doi.org/10.1186/1475-2859-10-85

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Large-scale functional expression of WT and truncated human adenosine A2A receptor in Pichia pastoris bioreactor cultures

Singh, Shweta; Gras, Adrien; Fiez-Vandal, Cédric et al. · 2008

Full title: Large-scale functional expression of WT and truncated human adenosine A2A receptor in Pichia pastoris bioreactor cultures

Authors: Singh, Shweta; Gras, Adrien; Fiez-Vandal, Cédric; Ruprecht, Jonathan J.; Rana, Rohini R.; Martínez, Magdalena; Strange, Philip G.; Wagner, Renaud; Byrne, Bernadette

DOI: https://doi.org/10.1186/1475-2859-7-28

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Heterologous expression of lcc1 gene from Trametes trogii in Pichia pastoris and characterization of the recombinant enzyme.

Colao, M. Ch.; Lupino, Stefania; Garzillo, Anna Maria Vittoria et al. · 2006

Full title: Heterologous expression of lcc1 gene from Trametes trogii in Pichia pastoris and characterization of the recombinant enzyme.

Authors: Colao, M. Ch.; Lupino, Stefania; Garzillo, Anna Maria Vittoria; Buonocore, Vincenzo; Ruzzi, Maurizio

DOI: https://doi.org/10.1186/1475-2859-5-31

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Comprehensive clone screening and evaluation of fed-batch strategies in a microbioreactor and lab scale stirred tank bioreactor system: application on Pichia pastoris producing Rhizopus oryzae lipase

Hemmerich, Johannes; Adelantado, Núria; Barrigón, José Manuel et al. · 2014

Authors: Hemmerich, Johannes; Adelantado, Núria; Barrigón, José Manuel; Ponte, Xavier; Hörmann, Astrid; Ferrer, Pau; Kensy, Frank; Valero, Francisco

DOI: https://doi.org/10.1186/1475-2859-13-36

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Regulation of methanol utilisation pathway genes in yeasts.

Hartner, Franz Stefan; Glieder, Anton · 2006

Full title: Regulation of methanol utilisation pathway genes in yeasts.

Authors: Hartner, Franz Stefan; Glieder, Anton

DOI: https://doi.org/10.1186/1475-2859-5-39

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Application of simple fed-batch technique to high-level secretory production of insulin precursor using Pichia pastoris with subsequent purification and conversion to human insulin

Gurramkonda, Chandrasekhar; Polez, Sulena; Skoko, Nataša et al. · 2010

Full title: Application of simple fed-batch technique to high-level secretory production of insulin precursor using Pichia pastoris with subsequent purification and conversion to human insulin

Authors: Gurramkonda, Chandrasekhar; Polez, Sulena; Skoko, Nataša; Adnan, Ahmad; Gäbel, Thomas; Chugh, Dipti A; Swaminathan, S.; Khanna, Navin; Tisminetzky, Sergio; Rinas, Ursula

DOI: https://doi.org/10.1186/1475-2859-9-31

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Versatile modeling and optimization of fed batch processes for the production of secreted heterologous proteins with Pichia pastoris

Maurer, Michael; Kühleitner, Manfred; Gasser, Brigitte et al. · 2006

Full title: Versatile modeling and optimization of fed batch processes for the production of secreted heterologous proteins with Pichia pastoris

Authors: Maurer, Michael; Kühleitner, Manfred; Gasser, Brigitte; Mattanovich, Diethard

DOI: https://doi.org/10.1186/1475-2859-5-37

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Operational strategies, monitoring and control of heterologous protein production in the methylotrophic yeast Pichia pastoris under different promoters: A review

Cós, Oriol; Ramón, Ramón; Montesinos, José Luis González et al. · 2006

Full title: Operational strategies, monitoring and control of heterologous protein production in the methylotrophic yeast Pichia pastoris under different promoters: A review

Authors: Cós, Oriol; Ramón, Ramón; Montesinos, José Luis González; Valero, Francisco

DOI: https://doi.org/10.1186/1475-2859-5-17

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Genome-scale metabolic reconstructions of Pichia stipitis and Pichia pastoris and in silico evaluation of their potentials

Caspeta, Luis; Shoaie, Saeed; Ågren, Rasmus et al. · 2012

Full title: Genome-scale metabolic reconstructions of Pichia stipitis and Pichia pastoris and in silico evaluation of their potentials

Authors: Caspeta, Luis; Shoaie, Saeed; Ågren, Rasmus; Nookaew, Intawat; Nielsen, Jens

DOI: https://doi.org/10.1186/1752-0509-6-24

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An effective combination of codon optimization, gene dosage, and process optimization for high-level production of fibrinolytic enzyme in Komagataella phaffii (Pichia pastoris)

Che, Zhiqun; Cao, Xiaoyan; Chen, Guiguang et al. · 2020

Full title: An effective combination of codon optimization, gene dosage, and process optimization for high-level production of fibrinolytic enzyme in Komagataella phaffii (Pichia pastoris)

Authors: Che, Zhiqun; Cao, Xiaoyan; Chen, Guiguang; Liang, Zhiqun

DOI: https://doi.org/10.1186/s12896-020-00654-7

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Functional recombinant protein is present in the pre-induction phases of Pichia pastoris cultures when grown in bioreactors, but not shake-flasks

Bawa, Zharain; Routledge, Sarah J; Jamshad, Mohammed et al. · 2014

Full title: Functional recombinant protein is present in the pre-induction phases of Pichia pastoris cultures when grown in bioreactors, but not shake-flasks

Authors: Bawa, Zharain; Routledge, Sarah J; Jamshad, Mohammed; Clare, Michelle; Sarkar, Debasmita; Dickerson, Ian M.; Ganzlin, Markus; Poyner, David R.; Bill, Roslyn M.

DOI: https://doi.org/10.1186/s12934-014-0127-y

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Engineered Pichia pastoris for enhanced production of S-adenosylmethionine

Kamarthapu, Venu; Srinivas, R.; Rao, Khareedu Venkateswara et al. · 2013

Full title: Engineered Pichia pastoris for enhanced production of S-adenosylmethionine

Authors: Kamarthapu, Venu; Srinivas, R.; Rao, Khareedu Venkateswara; Reddy, Vudem Dashavantha

DOI: https://doi.org/10.1186/2191-0855-3-40

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Dynamic genome-scale metabolic modeling of the yeast Pichia pastoris

Saitua, Francisco; Torres, Paulina; Pérez‐Correa, José Ricardo et al. · 2017

Full title: Dynamic genome-scale metabolic modeling of the yeast Pichia pastoris

Authors: Saitua, Francisco; Torres, Paulina; Pérez‐Correa, José Ricardo; Agosín, Eduardo

DOI: https://doi.org/10.1186/s12918-017-0408-2

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Treatment with surfactants enables quantification of translational activity by O-propargyl-puromycin labelling in yeast

Staudacher, Jennifer; Rebnegger, Corinna; Gasser, Brigitte · 2021

Full title: Treatment with surfactants enables quantification of translational activity by O-propargyl-puromycin labelling in yeast

Authors: Staudacher, Jennifer; Rebnegger, Corinna; Gasser, Brigitte

DOI: https://doi.org/10.1186/s12866-021-02185-3

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Developing a scalable model of recombinant protein yield from Pichia pastoris: the influence of culture conditions, biomass and induction regime

Holmes, William J.; Darby, Richard A. J.; Wilks, Martin DB et al. · 2009

Full title: Developing a scalable model of recombinant protein yield from Pichia pastoris: the influence of culture conditions, biomass and induction regime

Authors: Holmes, William J.; Darby, Richard A. J.; Wilks, Martin DB; Smith, Rodney; Bill, Roslyn M.

DOI: https://doi.org/10.1186/1475-2859-8-35

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The effect of hypoxia on the lipidome of recombinant Pichia pastoris

Adelantado, Núria; Tarazona, Pablo; Grillitsch, Karlheinz et al. · 2017

Full title: The effect of hypoxia on the lipidome of recombinant Pichia pastoris

Authors: Adelantado, Núria; Tarazona, Pablo; Grillitsch, Karlheinz; Garcia‐Ortega, Xavier; Monforte, Sergi; Valero, Francisco; Feußner, Ivo; Daum, Günther; Ferrer, Pau

DOI: https://doi.org/10.1186/s12934-017-0699-4

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Specific growth rate governs AOX1 gene expression, affecting the production kinetics of Pichia pastoris (Komagataella phaffii) PAOX1-driven recombinant producer strains with different target gene dosage

Garrigós‐Martínez, Javier; Nieto‐Taype, Miguel Angel; Gasset-Franch, Arnau et al. · 2019

Authors: Garrigós‐Martínez, Javier; Nieto‐Taype, Miguel Angel; Gasset-Franch, Arnau; Montesinos, José Luis González; Garcia‐Ortega, Xavier; Valero, Francisco

DOI: https://doi.org/10.1186/s12934-019-1240-8

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Development of a mixed feed strategy for a recombinant Pichia pastoris strain producing with a de-repression promoter

Capone, Simona; Horvat, Jernej; Herwig, Christoph et al. · 2015

Full title: Development of a mixed feed strategy for a recombinant Pichia pastoris strain producing with a de-repression promoter

Authors: Capone, Simona; Horvat, Jernej; Herwig, Christoph; Spadiut, Oliver

DOI: https://doi.org/10.1186/s12934-015-0292-7

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Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up

Madhavan, Aravind; Arun, K. B.; Sindhu, Raveendran et al. · 2021

Full title: Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up

Authors: Madhavan, Aravind; Arun, K. B.; Sindhu, Raveendran; Krishnamoorthy, Jayaram; Reshmy, R.; Sirohi, Ranjna; Pugazhendi, Arivalagan; Awasthi, Mukesh Kumar; Szakács, George; Binod, Parameswaran

DOI: https://doi.org/10.1186/s12934-021-01617-z

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Development of a fed-batch process for a recombinant Pichia pastoris Δoch1 strain expressing a plant peroxidase

Gmeiner, Christoph; Saadati, Amirhossein; Maresch, Daniel et al. · 2015

Full title: Development of a fed-batch process for a recombinant Pichia pastoris Δoch1 strain expressing a plant peroxidase

Authors: Gmeiner, Christoph; Saadati, Amirhossein; Maresch, Daniel; Krasteva, Stanimira; Frank, Manuela; Altmann, Friedrich; Herwig, Christoph; Spadiut, Oliver

DOI: https://doi.org/10.1186/s12934-014-0183-3

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An artificial neural network for membrane-bound catechol-O-methyltransferase biosynthesis with Pichia pastoris methanol-induced cultures

Pedro, Augusto Q.; Martins, Luís C.; Dias, João M.L. et al. · 2015

Full title: An artificial neural network for membrane-bound catechol-O-methyltransferase biosynthesis with Pichia pastoris methanol-induced cultures

Authors: Pedro, Augusto Q.; Martins, Luís C.; Dias, João M.L.; Bonifácio, Maria João; Queiroz, João A.; Passarinha, Luís A.

DOI: https://doi.org/10.1186/s12934-015-0304-7

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Validation of an FBA model for Pichia pastoris in chemostat cultures

Morales, Yeimy; Tortajada, Marta; Picó, Jesús et al. · 2014

Full title: Validation of an FBA model for Pichia pastoris in chemostat cultures

Authors: Morales, Yeimy; Tortajada, Marta; Picó, Jesús; Vehı́, Josep; Llaneras, Francisco

DOI: https://doi.org/10.1186/s12918-014-0142-y

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A novel bi-directional promoter system allows tunable recombinant protein production in Pichia pastoris

Rajamanickam, Vignesh; Metzger, Karl; Schmid, Christian et al. · 2017

Full title: A novel bi-directional promoter system allows tunable recombinant protein production in Pichia pastoris

Authors: Rajamanickam, Vignesh; Metzger, Karl; Schmid, Christian; Spadiut, Oliver

DOI: https://doi.org/10.1186/s12934-017-0768-8

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Optimization of construct design and fermentation strategy for the production of bioactive ATF-SAP, a saporin based anti-tumoral uPAR-targeted chimera

Provenzano, Alfredo Errico; Posteri, Riccardo; Giansanti, Francesco et al. · 2016

Full title: Optimization of construct design and fermentation strategy for the production of bioactive ATF-SAP, a saporin based anti-tumoral uPAR-targeted chimera

DOI: https://doi.org/10.1186/s12934-016-0589-1

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Optimizing expression of Nanobody® molecules in Pichia pastoris through co-expression of auxiliary proteins under methanol and methanol-free conditions

Groeve, Manu De; Laukens, Bram; Schotte, Peter · 2023

Full title: Optimizing expression of Nanobody® molecules in Pichia pastoris through co-expression of auxiliary proteins under methanol and methanol-free conditions

Authors: Groeve, Manu De; Laukens, Bram; Schotte, Peter

DOI: https://doi.org/10.1186/s12934-023-02132-z

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Uncoupling protein production from growth: different strategies for intracellular and secreted proteins in yeast

Temelli, Nuran; Baris, Willem H.; Weusthuis, Ruud A. et al. · 2025

Full title: Uncoupling protein production from growth: different strategies for intracellular and secreted proteins in yeast

Authors: Temelli, Nuran; Baris, Willem H.; Weusthuis, Ruud A.; Bisschops, Markus M.M.

DOI: https://doi.org/10.1186/s12934-025-02848-0

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Scalable production and application of Pichia pastoris whole cell catalysts expressing human cytochrome P450 2C9

Garrigós‐Martínez, Javier; Weninger, Astrid; Montesinos, José Luis González et al. · 2021

Full title: Scalable production and application of Pichia pastoris whole cell catalysts expressing human cytochrome P450 2C9

Authors: Garrigós‐Martínez, Javier; Weninger, Astrid; Montesinos, José Luis González; Schmid, Christian; Valero, Francisco; Rinnofner, Claudia; Glieder, Anton; Garcia‐Ortega, Xavier

DOI: https://doi.org/10.1186/s12934-021-01577-4

Paper

Methanol bioconversion into C3, C4, and C5 platform chemicals by the yeast Ogataea polymorpha

Wefelmeier, Katrin; Schmitz, Simone; Kösters, Benjamin Jonas et al. · 2024

Full title: Methanol bioconversion into C3, C4, and C5 platform chemicals by the yeast Ogataea polymorpha

Authors: Wefelmeier, Katrin; Schmitz, Simone; Kösters, Benjamin Jonas; Liebal, Ulf W.; Blank, Lars M.

DOI: https://doi.org/10.1186/s12934-023-02283-z

Paper

The nutritional composition and cell size of microbial biomass for food applications are defined by the growth conditions

Sakarika, Myrsini; Kerckhof, Frederiek‐Maarten; Peteghem, L. Van et al. · 2023

Full title: The nutritional composition and cell size of microbial biomass for food applications are defined by the growth conditions

DOI: https://doi.org/10.1186/s12934-023-02265-1

Paper

Economical production of Pichia pastoris single cell protein from methanol at industrial pilot scale

Jiao, Meng; Liu, Shufan; Gao, Le et al. · 2023

Full title: Economical production of Pichia pastoris single cell protein from methanol at industrial pilot scale

Authors: Jiao, Meng; Liu, Shufan; Gao, Le; Hong, Kai; Liu, Shuguang; Wu, Xin

DOI: https://doi.org/10.1186/s12934-023-02198-9

Paper

Bi-directionalized promoter systems allow methanol-free production of hard-to-express peroxygenases with Komagataella Phaffii

Besleaga, Mihail; Zimmermann, Christian; Ebner, Katharina et al. · 2024

Full title: Bi-directionalized promoter systems allow methanol-free production of hard-to-express peroxygenases with Komagataella Phaffii

Authors: Besleaga, Mihail; Zimmermann, Christian; Ebner, Katharina; Mach, Robert L.; Mach‐Aigner, Astrid R.; Geier, Martina; Glieder, Anton; Spadiut, Oliver; Kopp, Julian

DOI: https://doi.org/10.1186/s12934-024-02451-9

Paper

Enhancing the secretion pathway maximizes the effects of mixed feeding strategy for glucose oxidase production in the methylotrophic yeast Pichia pastoris

Bankefa, Olufemi Emmanuel; Wang, Meiyu; Zhu, Taicheng et al. · 2018

Full title: Enhancing the secretion pathway maximizes the effects of mixed feeding strategy for glucose oxidase production in the methylotrophic yeast Pichia pastoris

Authors: Bankefa, Olufemi Emmanuel; Wang, Meiyu; Zhu, Taicheng; Li, Yin

DOI: https://doi.org/10.1186/s40643-018-0211-y

Paper

Recombinant production of Paenibacillus wynnii β-galactosidase with Komagataella phaffii

Bechtel, Anna; Seitl, Ines; Proß, Eva et al. · 2024

Full title: Recombinant production of Paenibacillus wynnii β-galactosidase with Komagataella phaffii

Authors: Bechtel, Anna; Seitl, Ines; Proß, Eva; Hetzel, Frank; Keutgen, Mario; Fischer, Lutz

DOI: https://doi.org/10.1186/s12934-024-02544-5

Paper

Candida boidinii isolates from olive curation water: a promising platform for methanol-based biomanufacturing

Mota, Marta N.; Palma, Margarida; Sá‐Correia, Isabel · 2024

Full title: Candida boidinii isolates from olive curation water: a promising platform for methanol-based biomanufacturing

Authors: Mota, Marta N.; Palma, Margarida; Sá‐Correia, Isabel

DOI: https://doi.org/10.1186/s13568-024-01754-9

Paper

Expression and characterization of a novel 1,3-regioselective cold-adapted lipase from Rhizomucor endophyticus suitable for biodiesel synthesis

Yan, Qiaojuan; Duan, Xiaojie; Liu, Yu et al. · 2016

Full title: Expression and characterization of a novel 1,3-regioselective cold-adapted lipase from Rhizomucor endophyticus suitable for biodiesel synthesis

Authors: Yan, Qiaojuan; Duan, Xiaojie; Liu, Yu; Jiang, Zhengqiang; Yang, Shaoqing

DOI: https://doi.org/10.1186/s13068-016-0501-6

Paper

Secretory expression of cyclohexanone monooxygenase by methylotrophic yeast for efficient omeprazole sulfide bio-oxidation

Li, Yajing; Zheng, Yu‐Cong; Geng, Qiang et al. · 2021

Full title: Secretory expression of cyclohexanone monooxygenase by methylotrophic yeast for efficient omeprazole sulfide bio-oxidation

Authors: Li, Yajing; Zheng, Yu‐Cong; Geng, Qiang; Liu, Feng; Zhang, Zhi‐Jun; Xu, Jian‐He; Yu, Hui‐Lei

DOI: https://doi.org/10.1186/s40643-021-00430-1

Paper

Metabolic engineering of Komagataella phaffii for enhanced 3-hydroxypropionic acid (3-HP) production from methanol

Àvila-Cabré, Sílvia; Albiol, Joan; Ferrer, Pau · 2025

Full title: Metabolic engineering of Komagataella phaffii for enhanced 3-hydroxypropionic acid (3-HP) production from methanol

Authors: Àvila-Cabré, Sílvia; Albiol, Joan; Ferrer, Pau

DOI: https://doi.org/10.1186/s13036-025-00488-x

Paper

Avoiding overflow metabolite formation in Komagataella phaffii fermentations to enhance recombinant protein production

Steimann, Thomas; Wegmann, Judith; Espinosa, Monica I. et al. · 2024

Full title: Avoiding overflow metabolite formation in Komagataella phaffii fermentations to enhance recombinant protein production

Authors: Steimann, Thomas; Wegmann, Judith; Espinosa, Monica I.; Blank, Lars M.; Büchs, Jochen; Mann, Marcel; Magnus, Jørgen Barsett

DOI: https://doi.org/10.1186/s13036-024-00453-0

Paper

Efficient production of itaconic acid from the single-carbon substrate methanol with engineered Komagataella phaffii

Severinsen, Manja Mølgaard; Bachleitner, Simone; Modenese, Viola et al. · 2024

Full title: Efficient production of itaconic acid from the single-carbon substrate methanol with engineered Komagataella phaffii

Authors: Severinsen, Manja Mølgaard; Bachleitner, Simone; Modenese, Viola; Ata, Özge; Mattanovich, Diethard

DOI: https://doi.org/10.1186/s13068-024-02541-1

Paper

Current advances for omics-guided process optimization of microbial manufacturing

Wan, Shengtong; Liu, Xin; Sun, Wentao et al. · 2023

Full title: Current advances for omics-guided process optimization of microbial manufacturing

Authors: Wan, Shengtong; Liu, Xin; Sun, Wentao; Lv, Bo; Li, Chun

DOI: https://doi.org/10.1186/s40643-023-00647-2

Paper

Combined Strategies for Improving the Production of Recombinant Rhizopus oryzae Lipase in Pichia pastoris

Li, Xun; He, Xiaoyun; Li, Zhilin et al. · 2013

Full title: Combined Strategies for Improving the Production of Recombinant Rhizopus oryzae Lipase in Pichia pastoris

Authors: Li, Xun; He, Xiaoyun; Li, Zhilin; Wang, Fei

DOI: https://doi.org/10.15376/biores.8.2.2867-2880

Paper

Extracellular expression, purification and bioreactor production of tambaqui (Colossoma macropomum) growth hormone in the yeast Komagataella phaffii (formerly Pichia pastoris)

Sadalla-Pinto, Elson Antônio; ANDRADE, Edmar de; Carmo, Edson Júnior do et al. · 2024

Full title: Extracellular expression, purification and bioreactor production of tambaqui (Colossoma macropomum) growth hormone in the yeast Komagataella phaffii (formerly Pichia pastoris)

DOI: https://doi.org/10.1590/1809-4392202301791

Paper

Development of a Cost-Effective Process for the Heterologous Production of SARS-CoV-2 Spike Receptor Binding Domain (RBD) Using Pichia pastoris in Stirred-Tank Bioreactor

Noseda, Diego G.; D’Alessio, Cecilia; Santos, Javier et al. · 2023

Full title: Development of a Cost-Effective Process for the Heterologous Production of SARS-CoV-2 Spike Receptor Binding Domain (RBD) Using Pichia pastoris in Stirred-Tank Bioreactor

DOI: https://doi.org/10.3390/fermentation9060497

Paper

Enhancing Sustainability and Productivity in Komagataella phaffii Fermentation: A Techno-Economic Comparison of Fed-Batch and Continuous Cultivation with Mixed Induction Strategies

Yamanie, Almir; Magalhães, Salomé de Sá; Wijayadikusumah, Acep R. et al. · 2026

Authors: Yamanie, Almir; Magalhães, Salomé de Sá; Wijayadikusumah, Acep R.; Nurainy, Neni; Keshavarz-Moore, Eli

DOI: https://doi.org/10.20944/preprints202601.1265.v1

Paper

Leveraging Historical Process Data for Recombinant P. pastoris Fermentation Hybrid Deep Modeling and Model Predictive Control Development

Bolmanis, Emīls; Galvanauskas, Vytautas; Grīgs, Oskars et al. · 2025

Full title: Leveraging Historical Process Data for Recombinant P. pastoris Fermentation Hybrid Deep Modeling and Model Predictive Control Development

Authors: Bolmanis, Emīls; Galvanauskas, Vytautas; Grīgs, Oskars; Vanags, Juris; Kazāks, Andris

DOI: https://doi.org/10.20944/preprints202506.2217.v1

Paper

Two-phase fed-batch modification for 48 hour peak expression of hepatitis B surface antigen in Pichia pastoris shake flask system

Tam, Yew Joon; Allaudin, Zeenathul Nazariah; Rezaei, Morvarid Akhavan et al. · 2014

Full title: Two-phase fed-batch modification for 48 hour peak expression of hepatitis B surface antigen in Pichia pastoris shake flask system

Authors: Tam, Yew Joon; Allaudin, Zeenathul Nazariah; Rezaei, Morvarid Akhavan; Lila, Mohd Azmi Mohd; Bahaman, Abdul; Lo, Sewn Cen; Tan, Joo Shun

DOI: https://doi.org/10.2478/s11535-014-0309-y

Paper

Fed-Batch Production of Saccharomyces cerevisiae L-Asparaginase II by Recombinant Pichia pastoris MUTs Strain

Rodrigues, David; Pillaca‐Pullo, Omar; Torres‐Obreque, Karin Mariana et al. · 2019

Full title: Fed-Batch Production of Saccharomyces cerevisiae L-Asparaginase II by Recombinant Pichia pastoris MUTs Strain

DOI: https://doi.org/10.3389/fbioe.2019.00016

Paper

Innovative Bioprocess Strategies Combining Physiological Control and Strain Engineering of Pichia pastoris to Improve Recombinant Protein Production

Gasset, Arnau; Garcia‐Ortega, Xavier; Garrigós‐Martínez, Javier et al. · 2022

Full title: Innovative Bioprocess Strategies Combining Physiological Control and Strain Engineering of Pichia pastoris to Improve Recombinant Protein Production

Authors: Gasset, Arnau; Garcia‐Ortega, Xavier; Garrigós‐Martínez, Javier; Valero, Francisco; Montesinos, José Luis González

DOI: https://doi.org/10.3389/fbioe.2022.818434

Paper

PAOX1 expression in mixed-substrate continuous cultures of Komagataella phaffii (Pichia pastoris) is completely determined by methanol consumption regardless of the secondary carbon source

Singh, Anamika; Narang, Atul · 2023

Authors: Singh, Anamika; Narang, Atul

DOI: https://doi.org/10.3389/fbioe.2023.1123703

Paper

Bioproduction of the Recombinant Sweet Protein Thaumatin: Current State of the Art and Perspectives

Joseph, Jewel Ann; Akkermans, Simen; Nimmegeers, Philippe et al. · 2019

Full title: Bioproduction of the Recombinant Sweet Protein Thaumatin: Current State of the Art and Perspectives

Authors: Joseph, Jewel Ann; Akkermans, Simen; Nimmegeers, Philippe; Impe, Jan Van

DOI: https://doi.org/10.3389/fmicb.2019.00695

Paper

Continuous Process Verification 4.0 application in upstream: adaptiveness implementation managed by AI in the hypoxic bioprocess of the Pichia pastoris cell factory

Gasset, Arnau; Wijngaarden, Joeri van; Mirabent, Ferran et al. · 2024

Full title: Continuous Process Verification 4.0 application in upstream: adaptiveness implementation managed by AI in the hypoxic bioprocess of the Pichia pastoris cell factory

Authors: Gasset, Arnau; Wijngaarden, Joeri van; Mirabent, Ferran; Sales‐Vallverdú, Albert; Garcia‐Ortega, Xavier; Montesinos, José Luis González; Manzano, Toni; Valero, Francisco

DOI: https://doi.org/10.3389/fbioe.2024.1439638

Paper

Enhancement of thermoalkaliphilic xylanase production by Pichia pastoris through novel fed-batch strategy in high cell-density fermentation

Shang, Tingting; Si, Dayong; Zhang, Dongyan et al. · 2017

Full title: Enhancement of thermoalkaliphilic xylanase production by Pichia pastoris through novel fed-batch strategy in high cell-density fermentation

Authors: Shang, Tingting; Si, Dayong; Zhang, Dongyan; Liu, Xuhui; Zhao, Longmei; Hu, Cong; Fu, Yu; Zhang, Rijun

DOI: https://doi.org/10.1186/s12896-017-0361-6

Paper

Improved microscale cultivation of Pichia pastoris for clonal screening

Eck, Alexander; Schmidt, Matthias; Hamer, Stefanie Nicole et al. · 2018

Full title: Improved microscale cultivation of Pichia pastoris for clonal screening

Authors: Eck, Alexander; Schmidt, Matthias; Hamer, Stefanie Nicole; Ruff, Anna Joëlle; Förster, Jan Janosch; Schwaneberg, Ulrich; Blank, Lars M.; Wiechert, Wolfgang; Oldiges, Marco

DOI: https://doi.org/10.1186/s40694-018-0053-6

Thesis

Modelling and Optimization of Fed-Batch Filamentous Fungal Fermentation

Titica, M.; Bodizs, L.; Lei, F. et al. · 2004

Full title: Modelling and Optimization of Fed-Batch Filamentous Fungal Fermentation

Authors: Titica, M.; Bodizs, L.; Lei, F.; Srinivasan, B.; Dochain, D.; Bonvin, D.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/176798

Thesis

Bioreactor Controls for High Oxygen Uptake Rate (OUR) Demand Processes

Cho, Hyun Woo · 2019

Full title: Bioreactor Controls for High Oxygen Uptake Rate (OUR) Demand Processes

Authors: Cho, Hyun Woo

DOI: http://jhir.library.jhu.edu/handle/1774.2/60474

Thesis

Control of yeast fed-batch process through regulation of extracellular ethanol concentration

Cannizzaro, Christopher; Valentinotti, Sergio; Stockar, Urs · 2006

Full title: Control of yeast fed-batch process through regulation of extracellular ethanol concentration

Authors: Cannizzaro, Christopher; Valentinotti, Sergio; Stockar, Urs

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226110

Thesis

Probing Control of a Fedbatch Fermentation. Simulation and Implementation in ABB Industrial IT

Li, Tory · 2004

Full title: Probing Control of a Fedbatch Fermentation. Simulation and Implementation in ABB Industrial IT

Authors: Li, Tory

DOI: http://lup.lub.lu.se/student-papers/record/8848000

Thesis

Development of optimal fermentation expression systems for recombinant proteins: a thesis submitted in partial fulfilment of the requirements for the degree of Masters in Technology at Massey University

Manderson, Daniel · 2017

Authors: Manderson, Daniel

DOI: http://hdl.handle.net/10179/12019

Thesis

Expression of human epidermal growth factor in pichia pastoris and optimization of fermentation conditions

Eissazadeh, Samira · 2012

Full title: Expression of human epidermal growth factor in pichia pastoris and optimization of fermentation conditions

Authors: Eissazadeh, Samira

DOI: http://psasir.upm.edu.my/id/eprint/31605/1/FBSB%202012%2030R.pdf

Thesis

Development of Fermentation Technique for High Cell Density Cultivation of Baker's Yeast (Saccharomyces Cerevisae)

Ahmad Ariff · 2005

Full title: Development of Fermentation Technique for High Cell Density Cultivation of Baker's Yeast (Saccharomyces Cerevisae)

Authors: Ahmad Ariff

DOI: http://psasir.upm.edu.my/id/eprint/6761/1/IB_2005_8.pdf

Thesis

Fed-Batch Production of Saccharomyces cerevisiae L-Asparaginase II by Recombinant Pichia pastoris MUTs Strain

Pessoa Junior, Adalberto · 2019

Full title: Fed-Batch Production of Saccharomyces cerevisiae L-Asparaginase II by Recombinant Pichia pastoris MUTs Strain

Authors: Pessoa Junior, Adalberto

DOI: https://doi.org/10.3389/fbioe.2019.00016

Thesis

Production of protegrin-1 with a matrix metalloproteinase/elastase cleavage site and its therapeutic potential for skin wound infections

Hill, Emily · 2017

Full title: Production of protegrin-1 with a matrix metalloproteinase/elastase cleavage site and its therapeutic potential for skin wound infections

Authors: Hill, Emily

DOI: http://hdl.handle.net/10214/11495

Thesis

Design of a cultivation medium for protein production in Pichia pastoris based on genome-wide biological understanding

Matthews, Catherine Bartlett. · 2019

Full title: Design of a cultivation medium for protein production in Pichia pastoris based on genome-wide biological understanding

Authors: Matthews, Catherine Bartlett.

DOI: https://hdl.handle.net/1721.1/122528

Thesis

Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Hong, Moo Sun · 2022

Full title: Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Authors: Hong, Moo Sun

DOI: https://hdl.handle.net/1721.1/138943

Thesis

Quantitative characterization of a recombinant Pichia pastoris Mut+ strain secreting avidin using transient continuous cultures

Jungo, Carmen · 2007

Full title: Quantitative characterization of a recombinant Pichia pastoris Mut+ strain secreting avidin using transient continuous cultures

Authors: Jungo, Carmen

DOI: https://infoscience.epfl.ch/handle/20.500.14299/6151

Thesis

Probing Control : Analysis and Design with Application to Fed-Batch Bioreactors

Velut, Stéphane · 2005

Full title: Probing Control : Analysis and Design with Application to Fed-Batch Bioreactors

Authors: Velut, Stéphane

DOI: https://lup.lub.lu.se/record/24605

Thesis

Bench-Scale Production of Heterologous Proteins from Extremophiles- Escherichia coli and Pichia pastoris based expression systems

Ramchuran, Santosh · 2005

Full title: Bench-Scale Production of Heterologous Proteins from Extremophiles- Escherichia coli and Pichia pastoris based expression systems

Authors: Ramchuran, Santosh

DOI: https://lup.lub.lu.se/record/544473

Thesis

Perturbation-based Control of Industrial Fed-batch Bioprocesses

Johnsson, Ola · 2015

Full title: Perturbation-based Control of Industrial Fed-batch Bioprocesses

Authors: Johnsson, Ola

DOI: https://lup.lub.lu.se/record/8412104

Thesis

Probing Control in B. licheniformis Fermentations

Johnsson, Ola · 2010

Full title: Probing Control in B. licheniformis Fermentations

Authors: Johnsson, Ola

DOI: http://lup.lub.lu.se/student-papers/record/8847429

Thesis

Produção de glicerol quinase em Pichia pastoris

Aizemberg, Raquel [UNESP] · 2014

Full title: Produção de glicerol quinase em Pichia pastoris

Authors: Aizemberg, Raquel [UNESP]

DOI: http://hdl.handle.net/11449/88349

Thesis

Microbubble fermentation of recombinant Pichia pastoris for human serum albumin production

Zhang, Wei · 2014

Full title: Microbubble fermentation of recombinant Pichia pastoris for human serum albumin production

Authors: Zhang, Wei

DOI: http://hdl.handle.net/10919/33395

Thesis

Optimization of the production of recombinant macrophage inhibitory cytokine 1 (MIC-1) from Pichia pastoris

Pratanaphon, Ronachai · 2006

Full title: Optimization of the production of recombinant macrophage inhibitory cytokine 1 (MIC-1) from Pichia pastoris

Authors: Pratanaphon, Ronachai

DOI: http://hdl.handle.net/1959.4/68401

Thesis

Optimal conditions for cytochrome c production in batch and continuous culture.

Cail, Russell George · 1977

Full title: Optimal conditions for cytochrome c production in batch and continuous culture.

Authors: Cail, Russell George

DOI: http://hdl.handle.net/1959.4/59746

Thesis

Estratègies d’operació per a la producció de lipases de Rhizopus oryzae amb el fenotip Mut(s) de Pichia pastoris mitjançant substrats mixtes

Arnau Jiménez, Carol · 2011

Full title: Estratègies d’operació per a la producció de lipases de Rhizopus oryzae amb el fenotip Mut(s) de Pichia pastoris mitjançant substrats mixtes

Authors: Arnau Jiménez, Carol

DOI: http://hdl.handle.net/10803/42007

Thesis

Model-based design and development of operational strategies for Rhizopus oryzae lipase production in Pichia pastoris under the AOX1 promoter

Barrigón de San Marcos, José Manuel · 2015

Full title: Model-based design and development of operational strategies for Rhizopus oryzae lipase production in Pichia pastoris under the AOX1 promoter

Authors: Barrigón de San Marcos, José Manuel

DOI: http://hdl.handle.net/10803/287984

Thesis

Anàlisi quantitatiu de l’efecte de l’expressió d’una lipasa recombinant sobre el metabolisme central de Pichia pastoris

Jordà Murria, Joel · 2013

Full title: Anàlisi quantitatiu de l’efecte de l’expressió d’una lipasa recombinant sobre el metabolisme central de Pichia pastoris

Authors: Jordà Murria, Joel

DOI: http://hdl.handle.net/10803/117310

Thesis

L’increment de la dosi gènica com a estratègia de millora de la producció de proteïnes recombinants al llevat Pichia pastoris: revertint les limitacions genètiques del sistema biològic

Cámara Rey, Elena · 2017

Authors: Cámara Rey, Elena

DOI: http://hdl.handle.net/10803/399833

Thesis

Utilización de glicerol proveniente de la industria de biodiesel como fuente de carbono para la producción de lipasas recombinantes en Pichia pastoris.

Loango Chamorro, Nelsy · 2015

Full title: Utilización de glicerol proveniente de la industria de biodiesel como fuente de carbono para la producción de lipasas recombinantes en Pichia pastoris.

Authors: Loango Chamorro, Nelsy

DOI: http://hdl.handle.net/10803/313455

Thesis

Bioprocess efficiency as a roadmap to establish Pichia pastoris as a reliable cell factory

Ponte Font, Xavier · 2017

Full title: Bioprocess efficiency as a roadmap to establish Pichia pastoris as a reliable cell factory

Authors: Ponte Font, Xavier

DOI: http://hdl.handle.net/10803/457712

Thesis

Overcoming the secretory limitations in Pichia pastoris for recombinant protein production

Barrero Peña, Juan José · 2021

Full title: Overcoming the secretory limitations in Pichia pastoris for recombinant protein production

Authors: Barrero Peña, Juan José

DOI: http://hdl.handle.net/10803/670387

Thesis

Combining bioprocess and strain engineering strategies as efficient tools for the optimization of recombinant protein production in Pichia pastoris

Nieto Taype, Miguel Angel · 2020

Full title: Combining bioprocess and strain engineering strategies as efficient tools for the optimization of recombinant protein production in Pichia pastoris

Authors: Nieto Taype, Miguel Angel

DOI: http://hdl.handle.net/10803/670163

Thesis

Developing strategies for systems metabolic engineering of Pichia pastoris

Tomàs Gamisans, Màrius · 2017

Full title: Developing strategies for systems metabolic engineering of Pichia pastoris

Authors: Tomàs Gamisans, Màrius

DOI: http://hdl.handle.net/10803/458538

Thesis

Systematic metabolic analysis of recombinant Pichia pastoris under different oxygen conditions A Metabolome and Fluxome Based Study

Carnicer Heras, Marc · 2012

Full title: Systematic metabolic analysis of recombinant Pichia pastoris under different oxygen conditions A Metabolome and Fluxome Based Study

Authors: Carnicer Heras, Marc

DOI: http://hdl.handle.net/10803/96813

Thesis

Increasing biomass production in bioreactors applying metabolic analysis and engineering tools

Comas Sanchez, Pere · 2021

Full title: Increasing biomass production in bioreactors applying metabolic analysis and engineering tools

Authors: Comas Sanchez, Pere

DOI: http://hdl.handle.net/10803/671074

Thesis

Physiological control of Pichia pastoris for the production of recombinant proteins: A novel Respiratory Quotient control based on Artificial Intelligence and scale-up of the bioprocess

Gasset Franch, Arnau · 2024

Full title: Physiological control of Pichia pastoris for the production of recombinant proteins: A novel Respiratory Quotient control based on Artificial Intelligence and scale-up of the bioprocess

Authors: Gasset Franch, Arnau

DOI: http://hdl.handle.net/10803/691293

Thesis

Biomarkers to evaluate the effects of temperature and methanol on recombinant Pichia pastoris

Farías, Jorge G · 2014

Full title: Biomarkers to evaluate the effects of temperature and methanol on recombinant Pichia pastoris

Authors: Farías, Jorge G

DOI: http://www.scielo.br/pdf/bjm/v45n2/14.pdf

Thesis

Expression and Mutagenesis studies of Candida antactica lipase B

Rotticci-Mulder, Johanna C. · 2003

Full title: Expression and Mutagenesis studies of Candida antactica lipase B

Authors: Rotticci-Mulder, Johanna C.

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3493

Thesis

Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care

Cleto, Sara; Lee, Kevin; Perez-Pinera, Pablo et al. · 2017

Full title: Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care

Authors: Cleto, Sara; Lee, Kevin; Perez-Pinera, Pablo; Han, Ningren; Cao, Jicong; Purcell, Oliver; Shah, Kartik A; Ram, Rajeev J; Lu, Timothy K

DOI: http://hdl.handle.net/1721.1/109076

Thesis

Fed-batch microbioreactor platform for scale down and analysis of a plasmid DNA production process

Bower, Diana Morgan; Lee, Kevin Shao-Kwan; Ram, Rajeev J et al. · 2019

Full title: Fed-batch microbioreactor platform for scale down and analysis of a plasmid DNA production process

Authors: Bower, Diana Morgan; Lee, Kevin Shao-Kwan; Ram, Rajeev J; Prather, Kristala L

DOI: https://hdl.handle.net/1721.1/122647

Thesis

A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production

Lee, Kevin S.; Lee, Harry L. T.; Mozdzierz, Nicholas Joseph et al. · 2017

Full title: A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production

Authors: Lee, Kevin S.; Lee, Harry L. T.; Mozdzierz, Nicholas Joseph; Love, Kerry R.; Shah, Kartik A; Ram, Rajeev J; Love, John C

DOI: http://hdl.handle.net/1721.1/109453

Thesis

Macroscopic modeling of bioreactors for recombinant protein producing Pichia pastoris in defined medium

Hong, Moo Sun; Velez-Suberbie, M Lourdes; Maloney, Andrew J et al. · 2021

Full title: Macroscopic modeling of bioreactors for recombinant protein producing Pichia pastoris in defined medium

Authors: Hong, Moo Sun; Velez-Suberbie, M Lourdes; Maloney, Andrew J; Biedermann, Andrew; Love, Kerry R; Love, J Christopher; Mukhopadhyay, Tarit K; Braatz, Richard D

DOI: https://hdl.handle.net/1721.1/133351

Thesis

Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel et al. · 2025

Full title: Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Authors: Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel; Dang, Brendan; Wolffe, Lenna A; Atari, Adel; Tseng, Yuen-Yi; Love, J Christopher

DOI: https://hdl.handle.net/1721.1/163220

Thesis

Optimal Feeding Strategy for Bioreactors with Biomass Death

Bodizs, L.; Srinivasan, B.; Bonvin, D. · 2004

Full title: Optimal Feeding Strategy for Bioreactors with Biomass Death

Authors: Bodizs, L.; Srinivasan, B.; Bonvin, D.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/176738

Thesis

Optimal Operation of Fed-Batch Fermentations via Adaptive Control of Overflow Metabolite

Valentinotti, S.; Srinivasan, B.; Holmberg, U. et al. · 2004

Full title: Optimal Operation of Fed-Batch Fermentations via Adaptive Control of Overflow Metabolite

Authors: Valentinotti, S.; Srinivasan, B.; Holmberg, U.; Bonvin, D.; Cannizzaro, C.; Rhiel, M.; von Stockar, U.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/176209

Thesis

Oxygen Control for an Industrial Pilot-Scale Fed-Batch Filamentous Fungal Fermentation

Bodizs, Levente; Titica, Mariana; Faria, Nuno et al. · 2006

Full title: Oxygen Control for an Industrial Pilot-Scale Fed-Batch Filamentous Fungal Fermentation

Authors: Bodizs, Levente; Titica, Mariana; Faria, Nuno; Srinivasan, Bala; Dochain, Denis; Bonvin, Dominique

DOI: https://infoscience.epfl.ch/handle/20.500.14299/222030

Thesis

An Optimal Operating Strategy for Fed-Batch Fermentations by Feeding the Overflow Metabolite

Valentinotti, S.; Cannizzaro, C.; Srinivasan, B. et al. · 2004

Full title: An Optimal Operating Strategy for Fed-Batch Fermentations by Feeding the Overflow Metabolite

Authors: Valentinotti, S.; Cannizzaro, C.; Srinivasan, B.; Bonvin, D.

DOI: https://infoscience.epfl.ch/handle/20.500.14299/176669

Thesis

Extremum-Seeking Control of Industrial-Scale Fermentation Processes

Johnsson, Ola · 2013

Full title: Extremum-Seeking Control of Industrial-Scale Fermentation Processes

Authors: Johnsson, Ola

DOI: https://lup.lub.lu.se/record/4065043

Thesis

Multidisciplinary approach for recombinant protein production bioprocess design with classic and novel expression systems in Pichia pastoris

Garrigós Martínez, Javier · 2021

Full title: Multidisciplinary approach for recombinant protein production bioprocess design with classic and novel expression systems in Pichia pastoris

Authors: Garrigós Martínez, Javier

DOI: http://hdl.handle.net/10803/671119

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