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Downstream Purification Strategies For Recombinant

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219 papers 360 patents 292 theses

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Paper Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells.

Plouët, Jean; Ling, Xuefeng B.; Gospodarowicz, Denis · 1989 · The EMBO Journal · DOI

Full title: Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells.

Authors: Plouët, Jean; Ling, Xuefeng B.; Gospodarowicz, Denis

Year: 1989

Venue: The EMBO Journal

DOI: https://doi.org/10.1002/j.1460-2075.1989.tb08557.x

Paper Novel method for production and purification of untagged pneumococcal surface protein A from clade 1.

da Costa Rodrigues, Tasson; Zorzete, Patricia; Miyaji, Eliane Namie et al. · 2024 · Applied microbiology and biotechnology · DOI

Full title: Novel method for production and purification of untagged pneumococcal surface protein A from clade 1.

Authors: da Costa Rodrigues, Tasson; Zorzete, Patricia; Miyaji, Eliane Namie; Gonçalves, Viviane Maimoni

Year: 2024

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-024-13098-2

Paper Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain-based vaccine candidate, RBD219-N1C1.

Lee, Jungsoon; Liu, Zhuyun; Chen, Wen-Hsiang et al. · 2021 · Applied microbiology and biotechnology · DOI

Full title: Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain-based vaccine candidate, RBD219-N1C1.

Authors: Lee, Jungsoon; Liu, Zhuyun; Chen, Wen-Hsiang; Wei, Junfei; Kundu, Rakhi; Adhikari, Rakesh; Rivera, Joanne Altieri; Gillespie, Portia M; Strych, Ulrich; Zhan, Bin; Hotez, Peter J; Bottazzi, Maria Elena

Year: 2021

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-021-11281-3

Paper Foam fractionation Tags (F-Tags) enabling surfactant-free, activity-preserving recovery of enzymes.

Krause, Thomas; Keshavarzi, Behnam; Heitkam, Sascha et al. · 2024 · Applied microbiology and biotechnology · DOI

Full title: Foam fractionation Tags (F-Tags) enabling surfactant-free, activity-preserving recovery of enzymes.

Authors: Krause, Thomas; Keshavarzi, Behnam; Heitkam, Sascha; Ansorge-Schumacher, Marion B

Year: 2024

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-023-12837-1

Paper Comparison of downstream processing methods in purification of highly active laccase.

Antecka, Anna; Blatkiewicz, Michał; Boruta, Tomasz et al. · 2019 · Bioprocess and biosystems engineering · DOI

Full title: Comparison of downstream processing methods in purification of highly active laccase.

Authors: Antecka, Anna; Blatkiewicz, Michał; Boruta, Tomasz; Górak, Andrzej; Ledakowicz, Stanisław

Year: 2019

Venue: Bioprocess and biosystems engineering

DOI: https://doi.org/10.1007/s00449-019-02160-3

Paper Screening and identification of genetic loci involved in producing more/denser inclusion bodies in Escherichia coli.

Pandey, Neeraj; Sachan, Annapurna; Chen, Qi et al. · 2013 · Microbial cell factories · DOI

Full title: Screening and identification of genetic loci involved in producing more/denser inclusion bodies in Escherichia coli.

Authors: Pandey, Neeraj; Sachan, Annapurna; Chen, Qi; Ruebling-Jass, Kristin; Bhalla, Ritu; Panguluri, Kiran Kumar; Rouviere, Pierre E; Cheng, Qiong

Year: 2013

Venue: Microbial cell factories

DOI: https://doi.org/10.1186/1475-2859-12-43

Paper Recombinant expression of Barnase in Escherichia coli and its application in plasmid purification.

Shankar, Ram; Schäffer, Nina; Schmeer, Marco et al. · 2021 · Microbial cell factories · DOI

Full title: Recombinant expression of Barnase in Escherichia coli and its application in plasmid purification.

Authors: Shankar, Ram; Schäffer, Nina; Schmeer, Marco; Risse, Joe Max; Friehs, Karl; Schleef, Martin

Year: 2021

Venue: Microbial cell factories

DOI: https://doi.org/10.1186/s12934-021-01642-y

Paper Streamlined purification of ADDomer nanoparticles for scalable biomanufacturing.

Arinto-Garcia, Raquel; Paiva, Cláudia S; Dilla, Emerson Bryan et al. · 2025 · Journal of biological engineering · DOI

Full title: Streamlined purification of ADDomer nanoparticles for scalable biomanufacturing.

Authors: Arinto-Garcia, Raquel; Paiva, Cláudia S; Dilla, Emerson Bryan; Martens, Dirk E; Sargunas, Justin; Betenbaugh, Michael; Buzas, Dora; Balchin, Georgia; Moleirinho, Mafalda; Castro, Rute; Peixoto, Cristina; Berger, Imre; Schaffitzel, Christiane; Alves, Paula M; Roldão, António

Year: 2025

Venue: Journal of biological engineering

DOI: https://doi.org/10.1186/s13036-025-00558-0

Paper Economic purification of recombinant uricase by artificial oil bodies.

Saadat, Fatemeh; Macheroux, Peter; Alizadeh, Houshang et al. · 2022 · Bioresources and bioprocessing · DOI

Full title: Economic purification of recombinant uricase by artificial oil bodies.

Authors: Saadat, Fatemeh; Macheroux, Peter; Alizadeh, Houshang; Razavi, Seyed Hadi

Year: 2022

Venue: Bioresources and bioprocessing

DOI: https://doi.org/10.1186/s40643-022-00501-x

Paper Cost-effective downstream processing of recombinantly produced pexiganan peptide and its antimicrobial activity.

Sun, Baode; Wibowo, David; Middelberg, Anton P J et al. · 2018 · AMB Express · DOI

Full title: Cost-effective downstream processing of recombinantly produced pexiganan peptide and its antimicrobial activity.

Authors: Sun, Baode; Wibowo, David; Middelberg, Anton P J; Zhao, Chun-Xia

Year: 2018

Venue: AMB Express

DOI: https://doi.org/10.1186/s13568-018-0541-3

Paper Evaluation of novel large cut-off ultrafiltration membranes for adenovirus serotype 5 (Ad5) concentration.

Nestola, Piergiuseppe; Martins, Duarte L; Peixoto, Cristina et al. · 2014 · PloS one · DOI

Full title: Evaluation of novel large cut-off ultrafiltration membranes for adenovirus serotype 5 (Ad5) concentration.

Authors: Nestola, Piergiuseppe; Martins, Duarte L; Peixoto, Cristina; Roederstein, Susanne; Schleuss, Tobias; Alves, Paula M; Mota, José P B; Carrondo, Manuel J T

Year: 2014

Venue: PloS one

DOI: https://doi.org/10.1371/journal.pone.0115802

Paper Towards protein crystallization as a process step in downstream processing of therapeutic antibodies: screening and optimization at microbatch scale.

Zang, Yuguo; Kammerer, Bernd; Eisenkolb, Maike et al. · 2011 · PloS one · DOI

Full title: Towards protein crystallization as a process step in downstream processing of therapeutic antibodies: screening and optimization at microbatch scale.

Authors: Zang, Yuguo; Kammerer, Bernd; Eisenkolb, Maike; Lohr, Katrin; Kiefer, Hans

Year: 2011

Venue: PloS one

DOI: https://doi.org/10.1371/journal.pone.0025282

Paper Integrated Process for Capture and Purification of Virus-Like Particles: Enhancing Process Performance by Cross-Flow Filtration.

Hillebrandt, Nils; Vormittag, Philipp; Bluthardt, Nicolai et al. · 2020 · Frontiers in bioengineering and biotechnology · DOI

Full title: Integrated Process for Capture and Purification of Virus-Like Particles: Enhancing Process Performance by Cross-Flow Filtration.

Authors: Hillebrandt, Nils; Vormittag, Philipp; Bluthardt, Nicolai; Dietrich, Annabelle; Hubbuch, Jürgen

Year: 2020

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2020.00489

Paper A Generic Procedure for the Isolation of pH- and Magnesium-Responsive Chicken scFvs for Downstream Purification of Human Antibodies.

Hinz, Steffen C; Elter, Adrian; Rammo, Oliver et al. · 2020 · Frontiers in bioengineering and biotechnology · DOI

Full title: A Generic Procedure for the Isolation of pH- and Magnesium-Responsive Chicken scFvs for Downstream Purification of Human Antibodies.

Authors: Hinz, Steffen C; Elter, Adrian; Rammo, Oliver; Schwämmle, Achim; Ali, Ataurehman; Zielonka, Stefan; Herget, Thomas; Kolmar, Harald

Year: 2020

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2020.00688

Paper Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcγ Receptors: Implications for Measuring Fc Dependent Antibody Functions.

Lopez, Ester; Scott, Nichollas E; Wines, Bruce D et al. · 2019 · Frontiers in immunology · DOI

Full title: Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcγ Receptors: Implications for Measuring Fc Dependent Antibody Functions.

Authors: Lopez, Ester; Scott, Nichollas E; Wines, Bruce D; Hogarth, P Mark; Wheatley, Adam K; Kent, Stephen J; Chung, Amy W

Year: 2019

Venue: Frontiers in immunology

DOI: https://doi.org/10.3389/fimmu.2019.02415

Paper Magnetic Separation in Bioprocessing Beyond the Analytical Scale: From Biotechnology to the Food Industry.

Schwaminger, Sebastian P; Fraga-García, Paula; Eigenfeld, Marco et al. · 2019 · Frontiers in bioengineering and biotechnology · DOI

Full title: Magnetic Separation in Bioprocessing Beyond the Analytical Scale: From Biotechnology to the Food Industry.

Authors: Schwaminger, Sebastian P; Fraga-García, Paula; Eigenfeld, Marco; Becker, Thomas M; Berensmeier, Sonja

Year: 2019

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2019.00233

Paper Optimized Blanching Reduces the Host Cell Protein Content and Substantially Enhances the Recovery and Stability of Two Plant-Derived Malaria Vaccine Candidates.

Menzel, Stephan; Holland, Tanja; Boes, Alexander et al. · 2016 · Frontiers in plant science · DOI

Full title: Optimized Blanching Reduces the Host Cell Protein Content and Substantially Enhances the Recovery and Stability of Two Plant-Derived Malaria Vaccine Candidates.

Authors: Menzel, Stephan; Holland, Tanja; Boes, Alexander; Spiegel, Holger; Bolzenius, Johanna; Fischer, Rainer; Buyel, Johannes F

Year: 2016

Venue: Frontiers in plant science

DOI: https://doi.org/10.3389/fpls.2016.00159

Paper Extraction and purification of phycobiliproteins from algae and their applications.

Kovaleski, Gabriela; Kholany, Mariam; Dias, Lília M S et al. · 2022 · Frontiers in chemistry · DOI

Full title: Extraction and purification of phycobiliproteins from algae and their applications.

Authors: Kovaleski, Gabriela; Kholany, Mariam; Dias, Lília M S; Correia, Sandra F H; Ferreira, Rute A S; Coutinho, João A P; Ventura, Sónia P M

Year: 2022

Venue: Frontiers in chemistry

DOI: https://doi.org/10.3389/fchem.2022.1065355

Paper Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation.

Almeida, Catarina; Pedro, Augusto Q; Tavares, Ana P M et al. · 2023 · Frontiers in bioengineering and biotechnology · DOI

Full title: Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation.

Authors: Almeida, Catarina; Pedro, Augusto Q; Tavares, Ana P M; Neves, Márcia C; Freire, Mara G

Year: 2023

Venue: Frontiers in bioengineering and biotechnology

DOI: https://doi.org/10.3389/fbioe.2023.1037436

Paper Integrated Clarification and Purification of Monoclonal Antibodies by Membrane Based Separation of Aqueous Two-Phase Systems.

Kruse, Thomas; Schmidt, Axel; Kampmann, Markus et al. · 2019 · Antibodies (Basel, Switzerland) · DOI

Full title: Integrated Clarification and Purification of Monoclonal Antibodies by Membrane Based Separation of Aqueous Two-Phase Systems.

Authors: Kruse, Thomas; Schmidt, Axel; Kampmann, Markus; Strube, Jochen

Year: 2019

Venue: Antibodies (Basel, Switzerland)

DOI: https://doi.org/10.3390/antib8030040

Paper Affinity Membranes and Monoliths for Protein Purification.

Lalli, Eleonora; Silva, Jouciane S; Boi, Cristiana et al. · 2019 · Membranes · DOI

Full title: Affinity Membranes and Monoliths for Protein Purification.

Authors: Lalli, Eleonora; Silva, Jouciane S; Boi, Cristiana; Sarti, Giulio C

Year: 2019

Venue: Membranes

DOI: https://doi.org/10.3390/membranes10010001

Paper In-Line Monitoring of Downstream Purification Processes for VSV Based SARS-CoV-2 Vaccine Using a Novel Technique.

Makovitzki, Arik; Jayson, Avital; Oren, Ziv et al. · 2021 · Biotech (Basel (Switzerland)) · DOI

Full title: In-Line Monitoring of Downstream Purification Processes for VSV Based SARS-CoV-2 Vaccine Using a Novel Technique.

Authors: Makovitzki, Arik; Jayson, Avital; Oren, Ziv; Lerer, Elad; Kafri, Yaron; Dor, Eyal; Cherry, Lilach; Tzadok, Hanan; Levin, Lilach; Hazan, Ophir; Simon, Irit; Tal, Arnon; Girshengorn, Meni; Rosen, Osnat

Year: 2021

Venue: Biotech (Basel (Switzerland))

DOI: https://doi.org/10.3390/biotech10040025

Paper Scalable, Robust and Highly Productive Novel Convecdiff Membrane Platform for mAb Capture.

Grünberg, Mario; Kuchemüller, Kim B; Töppner, Katrin et al. · 2022 · Membranes · DOI

Full title: Scalable, Robust and Highly Productive Novel Convecdiff Membrane Platform for mAb Capture.

Authors: Grünberg, Mario; Kuchemüller, Kim B; Töppner, Katrin; Busse, Ricarda A

Year: 2022

Venue: Membranes

DOI: https://doi.org/10.3390/membranes12070677

Paper Applying UHPLC-HRAM MS/MS Method to Assess Host Cell Protein Clearance during the Purification Process Development of Therapeutic mAbs.

Kiyonami, Reiko; Melani, Rafael; Chen, Ying et al. · 2024 · International journal of molecular sciences · DOI

Full title: Applying UHPLC-HRAM MS/MS Method to Assess Host Cell Protein Clearance during the Purification Process Development of Therapeutic mAbs.

Authors: Kiyonami, Reiko; Melani, Rafael; Chen, Ying; Leon, A I De; Du, Min

Year: 2024

Venue: International journal of molecular sciences

DOI: https://doi.org/10.3390/ijms25179687

Paper Optimization of Tangential Flow Filtration for High-Yield, Scalable Downstream Processing of Adeno-Associated Virus.

Cardoso, Sara; Bollmann, Franziska; Tappe, Alexander · 2026 · Membranes · DOI

Full title: Optimization of Tangential Flow Filtration for High-Yield, Scalable Downstream Processing of Adeno-Associated Virus.

Authors: Cardoso, Sara; Bollmann, Franziska; Tappe, Alexander

Year: 2026

Venue: Membranes

DOI: https://doi.org/10.3390/membranes16020073

Paper Absolute Quantification of Hepatitis B Core Antigen (HBcAg) Virus-like Particles and Bound Nucleic Acids.

Valentic, Angela; Böhner, Nicola; Hubbuch, Jürgen · 2023 · Viruses · DOI

Full title: Absolute Quantification of Hepatitis B Core Antigen (HBcAg) Virus-like Particles and Bound Nucleic Acids.

Authors: Valentic, Angela; Böhner, Nicola; Hubbuch, Jürgen

Year: 2023

Venue: Viruses

DOI: https://doi.org/10.3390/v16010013

Paper Removal of Aggregates During Bispecific Antibody Purification Using Hydrophobic Interaction Chromatography.

Zhao, Puya; Qi, Yue; Gao, Kai · 2025 · Membranes · DOI

Full title: Removal of Aggregates During Bispecific Antibody Purification Using Hydrophobic Interaction Chromatography.

Authors: Zhao, Puya; Qi, Yue; Gao, Kai

Year: 2025

Venue: Membranes

DOI: https://doi.org/10.3390/membranes15100299

Paper Purification Process of a Recombinant Human Follicle Stimulating Hormone Biosimilar (Primapur®) to Yield a Pharmaceutical Product with High Batch-to-Batch Consistency.

Sinegubova, Maria; Vorobiev, Ivan; Klishin, Anatoly et al. · 2022 · Pharmaceutics · DOI

Full title: Purification Process of a Recombinant Human Follicle Stimulating Hormone Biosimilar (Primapur®) to Yield a Pharmaceutical Product with High Batch-to-Batch Consistency.

Authors: Sinegubova, Maria; Vorobiev, Ivan; Klishin, Anatoly; Eremin, Dmitry; Orlova, Nadezhda; Orlova, Natalya; Polzikov, Mikhail

Year: 2022

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics14010096

Paper Evaluation of the Robustness Verification of Downstream Production Process for Inactivated SARS-CoV-2 Vaccine and Different Chromatography Medium Purification Effects.

Pang, Jia-Hui; Guo, Chang-Fu; Hao, Peng-Liang et al. · 2024 · Vaccines · DOI

Full title: Evaluation of the Robustness Verification of Downstream Production Process for Inactivated SARS-CoV-2 Vaccine and Different Chromatography Medium Purification Effects.

Authors: Pang, Jia-Hui; Guo, Chang-Fu; Hao, Peng-Liang; Meng, Sheng-Li; Guo, Jing; Zhang, Dou; Ji, Ya-Qi; Ming, Ping-Gang

Year: 2024

Venue: Vaccines

DOI: https://doi.org/10.3390/vaccines12010056

Paper Membrane Chromatography-Based Downstream Processing for Cell-Culture Produced Influenza Vaccines.

Yang, Zeyu; Xu, Xingge; Silva, Cristina A T et al. · 2022 · Vaccines · DOI

Full title: Membrane Chromatography-Based Downstream Processing for Cell-Culture Produced Influenza Vaccines.

Authors: Yang, Zeyu; Xu, Xingge; Silva, Cristina A T; Farnos, Omar; Venereo-Sanchez, Alina; Toussaint, Cécile; Dash, Shantoshini; González-Domínguez, Irene; Bernier, Alice; Henry, Olivier; Kamen, Amine

Year: 2022

Venue: Vaccines

DOI: https://doi.org/10.3390/vaccines10081310

Paper Exploitation of Ultrasound Technique for Enhancement of Microbial Metabolites Production.

Behzadnia, Asma; Moosavi-Nasab, Marzieh; Ojha, Shikha et al. · 2020 · Molecules (Basel, Switzerland) · DOI

Full title: Exploitation of Ultrasound Technique for Enhancement of Microbial Metabolites Production.

Authors: Behzadnia, Asma; Moosavi-Nasab, Marzieh; Ojha, Shikha; Tiwari, Brijesh K

Year: 2020

Venue: Molecules (Basel, Switzerland)

DOI: https://doi.org/10.3390/molecules25225473

Paper Satisfying QTPP of Erythropoietin Biosimilar by QbD through DoE-Derived Downstream Process Engineering.

Nag, Kakon; Sarker, Enamul Haq; Kumar, Samir et al. · 2023 · Pharmaceutics · DOI

Full title: Satisfying QTPP of Erythropoietin Biosimilar by QbD through DoE-Derived Downstream Process Engineering.

Authors: Nag, Kakon; Sarker, Enamul Haq; Kumar, Samir; Chakraborty, Sourav; Khan, Maksusdur Rahman; Chowdhury, Mashfiqur Rahman; Roy, Rony; Roy, Ratan; Biswas, Bipul Kumar; Bappi, Emrul Hasan; Mohiuddin, Mohammad; Sultana, Naznin

Year: 2023

Venue: Pharmaceutics

DOI: https://doi.org/10.3390/pharmaceutics15082087

Paper Determining buffer conditions for downstream processing of VLP-based recombinant hepatitis B surface antigen using multimodal resins in bind-elute and flow-through purification modes.

Goodarzi, Maryam Moazami; Jalalirad, Reza; Doroud, Delaram et al. · 2023 · Scientific reports · DOI

Full title: Determining buffer conditions for downstream processing of VLP-based recombinant hepatitis B surface antigen using multimodal resins in bind-elute and flow-through purification modes.

Authors: Goodarzi, Maryam Moazami; Jalalirad, Reza; Doroud, Delaram; Hozouri, Hamidreza; Aghasadeghi, Mohammadreza; Paryan, Mahdi

Year: 2023

Venue: Scientific reports

DOI: https://doi.org/10.1038/s41598-023-37614-y

Paper Toward microfluidic continuous-flow and intelligent downstream processing of biopharmaceuticals.

Sharma, Vikas; Mottafegh, Amirreza; Joo, Jeong-Un et al. · 2024 · Lab on a chip · DOI

Full title: Toward microfluidic continuous-flow and intelligent downstream processing of biopharmaceuticals.

Authors: Sharma, Vikas; Mottafegh, Amirreza; Joo, Jeong-Un; Kang, Ji-Ho; Wang, Lei; Kim, Dong-Pyo

Year: 2024

Venue: Lab on a chip

DOI: https://doi.org/10.1039/d3lc01097j

Paper Quality assessment and optimization of purified protein samples: why and how?

Raynal, Bertrand; Lenormand, Pascal; Baron, Bruno et al. · 2014 · Microbial cell factories · DOI

Full title: Quality assessment and optimization of purified protein samples: why and how?

Authors: Raynal, Bertrand; Lenormand, Pascal; Baron, Bruno; Hoos, Sylviane; England, Patrick

Year: 2014

Venue: Microbial cell factories

DOI: https://doi.org/10.1186/s12934-014-0180-6

Paper The lyophilized chloroplasts store synthetic DARPin G3 as bioactive encapsulated organelles.

Ehsasatvatan, Maryam; Kohnehrouz, Bahram Baghban · 2023 · Journal of biological engineering · DOI

Full title: The lyophilized chloroplasts store synthetic DARPin G3 as bioactive encapsulated organelles.

Authors: Ehsasatvatan, Maryam; Kohnehrouz, Bahram Baghban

Year: 2023

Venue: Journal of biological engineering

DOI: https://doi.org/10.1186/s13036-023-00383-3

Paper Protein purification strategies must consider downstream applications and individual biological characteristics.

Remans, Kim; Lebendiker, Mario; Abreu, Celeste et al. · 2022 · Microbial cell factories · DOI

Full title: Protein purification strategies must consider downstream applications and individual biological characteristics.

Authors: Remans, Kim; Lebendiker, Mario; Abreu, Celeste; Maffei, Mariano; Sellathurai, Shaila; May, Marina M; Vaněk, Ondřej; de Marco, Ario

Year: 2022

Venue: Microbial cell factories

DOI: https://doi.org/10.1186/s12934-022-01778-5

Paper Downstream processing of recombinant human insulin and its analogues production from E. coli inclusion bodies.

Siew, Yin Yin; Zhang, Wei · 2021 · Bioresources and bioprocessing · DOI

Full title: Downstream processing of recombinant human insulin and its analogues production from E. coli inclusion bodies.

Authors: Siew, Yin Yin; Zhang, Wei

Year: 2021

Venue: Bioresources and bioprocessing

DOI: https://doi.org/10.1186/s40643-021-00419-w

Thesis Resin Lifetime and Aging Behavior in Protein A Chromatography

Gooley, Sarah · 2024 · Johns Hopkins University · DOI

Full title: Resin Lifetime and Aging Behavior in Protein A Chromatography

Authors: Gooley, Sarah

Year: 2024

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/69585

Thesis Eukaryotic expression, purification and structure/function analysis of native, recombinant CRISP3 from human and mouse

Volpert, M; Mangum, JE; Jamsai, D et al. · 2021 · University of Melbourne · DOI

Full title: Eukaryotic expression, purification and structure/function analysis of native, recombinant CRISP3 from human and mouse

Authors: Volpert, M; Mangum, JE; Jamsai, D; D'Sylva, R; O'Bryan, MK; McIntyre, P

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/265721

Thesis HIGH EFFICIENCY AFFINITY CAPTURE AND PURIFICATION OF IMMUNOGLOBULIN G USING MAGNETIC PARTICLES WITH BIOINSPIRIED PEPTIDE LIGANDS

Ou, Shih-Hao · 2019 · Johns Hopkins University · DOI

Full title: HIGH EFFICIENCY AFFINITY CAPTURE AND PURIFICATION OF IMMUNOGLOBULIN G USING MAGNETIC PARTICLES WITH BIOINSPIRIED PEPTIDE LIGANDS

Authors: Ou, Shih-Hao

Year: 2019

Venue: Johns Hopkins University

DOI: http://jhir.library.jhu.edu/handle/1774.2/61606

Thesis Application of mechanistic modelling in membrane and fiber chromatography for purification of biotherapeutics — A review

Qu, Y; Baker, I; Black, J et al. · 2024 · University of Melbourne · DOI

Full title: Application of mechanistic modelling in membrane and fiber chromatography for purification of biotherapeutics — A review

Authors: Qu, Y; Baker, I; Black, J; Fabri, L; Gras, SL; Lenhoff, AM; Kentish, SE

Year: 2024

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/340258

Thesis Establishment of a yeast-based VLP platform for antigen presentation

Wetzel, D; Rolf, T; Suckow, M et al. · 2020 · University of Melbourne · DOI

Full title: Establishment of a yeast-based VLP platform for antigen presentation

Authors: Wetzel, D; Rolf, T; Suckow, M; Kranz, A; Barbian, A; Chan, JA; Leitsch, J; Weniger, M; Jenzelewski, V; Kouskousis, B; Palmer, C; Beeson, JG; Schembecker, G; Merz, J; Piontek, M

Year: 2020

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/255894

Thesis Eplt4 Proteinaceous Elicitor Produced in Pichia pastoris Has a Protective Effect Against Cercosporidium sofinum Infections of Soybean Leaves

Wang, Y; Song, J; Wu, Y et al. · 2021 · University of Melbourne · DOI

Full title: Eplt4 Proteinaceous Elicitor Produced in Pichia pastoris Has a Protective Effect Against Cercosporidium sofinum Infections of Soybean Leaves

Authors: Wang, Y; Song, J; Wu, Y; Odeph, M; Liu, Z; Howlett, BJ; Wang, S; Yang, P; Yao, L; Zhao, L; Yang, Q

Year: 2021

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/283084

Thesis Digitalization in biopharmaceutical downstream processes

Espinoza, Daniel · 2024 · Lund University (LUP) · DOI

Full title: Digitalization in biopharmaceutical downstream processes

Authors: Espinoza, Daniel

Year: 2024

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/f936d3e3-244e-4f3b-812a-6866d82a1eee

Thesis Modeling and Optimization of an Integrated Column Sequence with In-Line Dilution for Continuous Chromatography of Proteins

Fridlund, Christian · 2016 · Lund University Student Papers · DOI

Full title: Modeling and Optimization of an Integrated Column Sequence with In-Line Dilution for Continuous Chromatography of Proteins

Authors: Fridlund, Christian

Year: 2016

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/8882081

Thesis A Model-based Approach to Evaluating Chromatography Capture Steps

Ulmestig, Jakob · 2017 · Lund University Student Papers · DOI

Full title: A Model-based Approach to Evaluating Chromatography Capture Steps

Authors: Ulmestig, Jakob

Year: 2017

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/8928249

Thesis Cloning, expression and production of Vicia faba Leghemoglobin B

Lindéus, Gustav · 2016 · Lund University Student Papers · DOI

Full title: Cloning, expression and production of Vicia faba Leghemoglobin B

Authors: Lindéus, Gustav

Year: 2016

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/8880323

Thesis Performance analysis of a PEGylation process -Process comparison of a tubular reactor with recirculation to a conventional batch reactor

Torbica, Boris · 2015 · Lund University Student Papers · DOI

Full title: Performance analysis of a PEGylation process -Process comparison of a tubular reactor with recirculation to a conventional batch reactor

Authors: Torbica, Boris

Year: 2015

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/8052030

Thesis Overexpression and Purification of Mouse Divalent Metal Transporter 1 (mDMT1) from Saccharomyces cerevisiae

Arbab, Olivia · 2016 · Lund University Student Papers · DOI

Full title: Overexpression and Purification of Mouse Divalent Metal Transporter 1 (mDMT1) from Saccharomyces cerevisiae

Authors: Arbab, Olivia

Year: 2016

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/8892046

Thesis Small Scale Monoclonal Antibody Purification Platform

Nielsen, Eric · 2022 · Lund University Student Papers · DOI

Full title: Small Scale Monoclonal Antibody Purification Platform

Authors: Nielsen, Eric

Year: 2022

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9075211

Thesis Double-layer vs single-layer cryogels as a dye affinity chromatography column, comparison study

Trinh, Thi Hoai Thu · 2022 · Lund University Student Papers · DOI

Full title: Double-layer vs single-layer cryogels as a dye affinity chromatography column, comparison study

Authors: Trinh, Thi Hoai Thu

Year: 2022

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9079984

Thesis Optimization of Recombinant Phytoglobin Production

Rollén, Emelie; Bergström Gombrii, Hanna · 2025 · Lund University Student Papers · DOI

Full title: Optimization of Recombinant Phytoglobin Production

Authors: Rollén, Emelie; Bergström Gombrii, Hanna

Year: 2025

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9198619

Thesis Designing a Multifunctional Chromatography Stationary Phase for (Bio)Product Purification via Green Chemistry

Lei, Xiaolin · 2024 · Lund University Student Papers · DOI

Full title: Designing a Multifunctional Chromatography Stationary Phase for (Bio)Product Purification via Green Chemistry

Authors: Lei, Xiaolin

Year: 2024

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9167848

Thesis Model Calibration and Optimization of a Protein Purification Process

Al-Kaisy, Sadiq · 2015 · Lund University Student Papers · DOI

Full title: Model Calibration and Optimization of a Protein Purification Process

Authors: Al-Kaisy, Sadiq

Year: 2015

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/5470040

Thesis Iterative Learning Control for Preparative Chromatography

Espinoza, Daniel · 2020 · Lund University Student Papers · DOI

Full title: Iterative Learning Control for Preparative Chromatography

Authors: Espinoza, Daniel

Year: 2020

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9007394

Thesis Elution Trajectory Optimization for Chromatographic Separation

Wacker, Philipp · 2025 · Lund University Student Papers · DOI

Full title: Elution Trajectory Optimization for Chromatographic Separation

Authors: Wacker, Philipp

Year: 2025

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9193662

Thesis Expression and purification of pyruvate transporting human mitochondrial pyruvate carrier (MPC) protein complex for structural studies

Wendler, Markus · 2022 · Lund University Student Papers · DOI

Full title: Expression and purification of pyruvate transporting human mitochondrial pyruvate carrier (MPC) protein complex for structural studies

Authors: Wendler, Markus

Year: 2022

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9082213

Thesis Protein Recovery from Alkaline Extracts: A Comparative Analysis of Isoelectric Precipitation and Ultrafiltration

Sharma, Anjay · 2023 · Lund University Student Papers · DOI

Full title: Protein Recovery from Alkaline Extracts: A Comparative Analysis of Isoelectric Precipitation and Ultrafiltration

Authors: Sharma, Anjay

Year: 2023

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9140482

Thesis Simulation of periodic counter-current chromatography purification of monoclonal antibodies with column degradation

Friberg, Erik · 2022 · Lund University Student Papers · DOI

Full title: Simulation of periodic counter-current chromatography purification of monoclonal antibodies with column degradation

Authors: Friberg, Erik

Year: 2022

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9102373

Thesis Optimizing Expression and Purification of HaTRPA1

Hansson Wennersten, Wilhelm · 2024 · Lund University Student Papers · DOI

Full title: Optimizing Expression and Purification of HaTRPA1

Authors: Hansson Wennersten, Wilhelm

Year: 2024

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9159056

Thesis A mutational analysis of the hinge region of the N-lobe of lactoferrin : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University

Shewry, Steven Christopher · 2018 · Massey University · DOI

Full title: A mutational analysis of the hinge region of the N-lobe of lactoferrin : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University

Authors: Shewry, Steven Christopher

Year: 2018

Venue: Massey University

DOI: http://hdl.handle.net/10179/12822

Thesis Expression, purification and mutagenesis of recombinant class 1 Aldehyde dehydrogenase : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Molecular Biology at Massey University /

Wyatt, Jane Margaret · 2018 · Massey University · DOI

Full title: Expression, purification and mutagenesis of recombinant class 1 Aldehyde dehydrogenase : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Molecular Biology at Massey University /

Authors: Wyatt, Jane Margaret

Year: 2018

Venue: Massey University

DOI: http://hdl.handle.net/10179/12530

Thesis Production of phospholipase A2 from recombinant yarrowia lipolytica biopharmaceutical application

Mokhtar, Nur'Ainun · 2013 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Production of phospholipase A2 from recombinant yarrowia lipolytica biopharmaceutical application

Authors: Mokhtar, Nur'Ainun

Year: 2013

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/38650/1/FPSK%28m%29%202013%2031%20IR.pdf

Thesis Recovery of α-lactalbumin from whey protein isolate and osteopontin from milk by anion exchangers : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Chemistry at Massey University, New Zealand

Chen, Yishan · 2021 · Massey University · DOI

Full title: Recovery of α-lactalbumin from whey protein isolate and osteopontin from milk by anion exchangers : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Chemistry at Massey University, New Zealand

Authors: Chen, Yishan

Year: 2021

Venue: Massey University

DOI: http://hdl.handle.net/10179/15959

Thesis Cloning, Expression and Characterization of Hepatitis B Large Surface Antigen In Yeast System

Mohamad Sinang, Fazia · 2010 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Cloning, Expression and Characterization of Hepatitis B Large Surface Antigen In Yeast System

Authors: Mohamad Sinang, Fazia

Year: 2010

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/21265/1/FBSB_2010_3_R.pdf

Thesis Development of dye affinity adsorbents for recovery of polyclonal anti-hepatitis B core antigen immunoglobulin G

Wongchuphan, Rattana · 2010 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Development of dye affinity adsorbents for recovery of polyclonal anti-hepatitis B core antigen immunoglobulin G

Authors: Wongchuphan, Rattana

Year: 2010

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/41141/1/FK%202010%2076R.pdf

Thesis Biomanufacturing of an organic solvent tolerant and thermostable lipase by recombinant E. coli

Nelofer, Rubina · 2012 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Biomanufacturing of an organic solvent tolerant and thermostable lipase by recombinant E. coli

Authors: Nelofer, Rubina

Year: 2012

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/33307/1/FBSB%202012%2019R.pdf

Thesis Production and electrophoresis-based purification of recombinant green fluorescent protein from Escherichia coli

Chew, Few Ne · 2011 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Production and electrophoresis-based purification of recombinant green fluorescent protein from Escherichia coli

Authors: Chew, Few Ne

Year: 2011

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/42335/1/FK%202011%20103R.pdf

Thesis Recovery and purification of epidermal growth factor from fermentation broth using expanded bed chromatography

Rosti, Ira Amira · 2013 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Recovery and purification of epidermal growth factor from fermentation broth using expanded bed chromatography

Authors: Rosti, Ira Amira

Year: 2013

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/40046/1/IB%202013%2019%20ir.pdf

Thesis Purification of Human Interferon Alpha-2b from Eschericha Coli Using Aqueous Two-Phase Systems

Lin, Yu Kiat · 2011 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Purification of Human Interferon Alpha-2b from Eschericha Coli Using Aqueous Two-Phase Systems

Authors: Lin, Yu Kiat

Year: 2011

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/20038/1/IB_2011_10_ir.pdf

Thesis Simple surface plasmon resonance bio-sensor for the quantification of recombinant human epidermal growth factor (rhEGF) in expanded bed recovery

Faizal Wong, Fadzlie Wong · 2010 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Simple surface plasmon resonance bio-sensor for the quantification of recombinant human epidermal growth factor (rhEGF) in expanded bed recovery

Authors: Faizal Wong, Fadzlie Wong

Year: 2010

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/41137/1/FK%202010%2073R.pdf

Thesis Expanded bed anion exchange adsorption for the purification of bacteriophage M13

Shamsu Zaman, Mayamarni · 2009 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Expanded bed anion exchange adsorption for the purification of bacteriophage M13

Authors: Shamsu Zaman, Mayamarni

Year: 2009

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/51065/1/FK%202008%2097RR.pdf

Thesis Direct Recovery of Recombinant Hepatitis B Core Antigen from Unclarified Escherichia Coli Feedstock Using Expanded Bed Adsorption Chromatography

Ng, Michelle Yeen Tan · 2008 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Direct Recovery of Recombinant Hepatitis B Core Antigen from Unclarified Escherichia Coli Feedstock Using Expanded Bed Adsorption Chromatography

Authors: Ng, Michelle Yeen Tan

Year: 2008

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/5392/1/IB_2008_5.pdf

Thesis High throughput optimization of protein-A affinity chromatography for capture of humanized monoclonal antibody

Pakiman, Norazrina · 2012 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: High throughput optimization of protein-A affinity chromatography for capture of humanized monoclonal antibody

Authors: Pakiman, Norazrina

Year: 2012

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/48480/1/FK%202012%20123R.pdf

Thesis Development Of An Integrated Recovery Process For Recombinant Hepatitis B Core Antigen

Ho, Chin Woi · 2007 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Development Of An Integrated Recovery Process For Recombinant Hepatitis B Core Antigen

Authors: Ho, Chin Woi

Year: 2007

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/5210/1/FK_2007_27.pdf

Thesis Establishment of optimise strategies in production of recombinant Hepatitis B surface antigen for chip-based antibody detection approach

Tam, Yew Joon · 2015 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Establishment of optimise strategies in production of recombinant Hepatitis B surface antigen for chip-based antibody detection approach

Authors: Tam, Yew Joon

Year: 2015

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/64029/1/IB%202015%2011.pdf

Thesis Production and purification of nipah virus glycoprotein in Spodoptera frugiperda 9 (J.E. Smith) insect cell

Sunhare, Raksha · 2013 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Production and purification of nipah virus glycoprotein in Spodoptera frugiperda 9 (J.E. Smith) insect cell

Authors: Sunhare, Raksha

Year: 2013

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/40015/1/IB%202013%209.pdf

Thesis The Influence Of M13 Bacteriophage On Protein Adsorption Using Anion Exchange Expanded Bed Chromatography

Mohamed @ Mahmood, Masniza · 2006 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: The Influence Of M13 Bacteriophage On Protein Adsorption Using Anion Exchange Expanded Bed Chromatography

Authors: Mohamed @ Mahmood, Masniza

Year: 2006

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/5162/1/FK_2006_108a.pdf

Thesis Expression And Characterization Of Recombinant Thermostable L2 Lipase In Pichia Pastoris

Sabri, Suriana · 2007 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Expression And Characterization Of Recombinant Thermostable L2 Lipase In Pichia Pastoris

Authors: Sabri, Suriana

Year: 2007

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/4857/1/FBSB_2007_1.pdf

Thesis Expression of recombinant geobacillus SP a-amylase in pichia pastoris GS 115

Gandhi, Sivasangkary · 2014 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Expression of recombinant geobacillus SP a-amylase in pichia pastoris GS 115

Authors: Gandhi, Sivasangkary

Year: 2014

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/56821/1/IB%202014%2018.pdf

Thesis Purification and characterization of polyclonal anti-hepatitis B core antigen immunoglobulin G from rabbit serum

Sayed Hitam, Sharifah Mariam · 2016 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Purification and characterization of polyclonal anti-hepatitis B core antigen immunoglobulin G from rabbit serum

Authors: Sayed Hitam, Sharifah Mariam

Year: 2016

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/69717/1/IB%202016%207%20IR.pdf

Thesis Nucleocapsid and matrix proteins of nipah virus produced in Pichia pastoris and their interaction

Narcisse Mary, Sither Joseph Vesudian · 2016 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Nucleocapsid and matrix proteins of nipah virus produced in Pichia pastoris and their interaction

Authors: Narcisse Mary, Sither Joseph Vesudian

Year: 2016

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/68994/7/FBSB%202016%2012%20IR%20edit.pdf

Thesis Facilitative recovery of cyclodextrin glucanotransferase using chromatographic strategies

Sivapragasam, Magaret · 2014 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Facilitative recovery of cyclodextrin glucanotransferase using chromatographic strategies

Authors: Sivapragasam, Magaret

Year: 2014

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/66665/1/IB%202014%2022%20IR.pdf

Thesis Purification on a Recombinant Nucleocapsid Protein of Newcastle Disease Virus Using Expanded Bed Adsorption Chromatography

Tan, Yan Peng · 2005 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Purification on a Recombinant Nucleocapsid Protein of Newcastle Disease Virus Using Expanded Bed Adsorption Chromatography

Authors: Tan, Yan Peng

Year: 2005

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/6038/1/FK_2005_28.pdf

Thesis Expression of recombinant thermostable W200R protease in Pichia pastoris

Mohamad Sultan, Muhamad Zarir · 2011 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Expression of recombinant thermostable W200R protease in Pichia pastoris

Authors: Mohamad Sultan, Muhamad Zarir

Year: 2011

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/67162/1/IB%202012%2028%20IR.pdf

Thesis A Simplified and Selective Technique for The Direct Recovery of Glucose-6-Phosphate Dehydrogenase From Unclarified Yeast Feedstock

Chow, Yen Mei · 2005 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: A Simplified and Selective Technique for The Direct Recovery of Glucose-6-Phosphate Dehydrogenase From Unclarified Yeast Feedstock

Authors: Chow, Yen Mei

Year: 2005

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/6036/1/FK_2005_27.pdf

Thesis Periplasmic Expression, Recovery and Quantification of Recombinant Human Interferon-A2b in Fermentation by Escherichia Coli

Ramanan, R. Nagasundara · 2009 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Periplasmic Expression, Recovery and Quantification of Recombinant Human Interferon-A2b in Fermentation by Escherichia Coli

Authors: Ramanan, R. Nagasundara

Year: 2009

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/7552/1/ABS_---__IB_2009_13.pdf

Thesis Purification of long helical capsid of newcastle disease virus from Escherichia coli

Yap, Chee Fai · 2013 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Purification of long helical capsid of newcastle disease virus from Escherichia coli

Authors: Yap, Chee Fai

Year: 2013

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/38658/1/IB%202013%205R.pdf

Thesis Chromatographic Purification of Recombinant Nucleocapsid Protein of Nipah Virus from Escherichia Coli Homogenate

Chong, Fui Chin · 2010 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Chromatographic Purification of Recombinant Nucleocapsid Protein of Nipah Virus from Escherichia Coli Homogenate

Authors: Chong, Fui Chin

Year: 2010

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/7849/1/ABS_%3D%3D%3D%3D__FK_2010_3.pdf

Thesis Development of molecular tools for Komagataella phaffii and exploring its use for orally administered biopharmaceuticals

Vanluchene, Robin · 2020 · Ghent University (Universiteit Gent) · DOI

Full title: Development of molecular tools for Komagataella phaffii and exploring its use for orally administered biopharmaceuticals

Authors: Vanluchene, Robin

Year: 2020

Venue: Ghent University (Universiteit Gent)

DOI: https://biblio.ugent.be/publication/8684279

Thesis Mechanistic modeling and scale-up investigation of a preparative two-column purification step for a biopharmaceutical polypeptide

Koch, Jonas Martin Maria · 2024 · Heidelberg University · DOI

Full title: Mechanistic modeling and scale-up investigation of a preparative two-column purification step for a biopharmaceutical polypeptide

Authors: Koch, Jonas Martin Maria

Year: 2024

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/34272/1/Dissertation_Koch_Jonas.pdf

Thesis Production of biosimilar trastuzumab in plants: Expression, purification, and analysis of function

Grohs, Brittany Marie · 2020 · University of Guelph · DOI

Full title: Production of biosimilar trastuzumab in plants: Expression, purification, and analysis of function

Authors: Grohs, Brittany Marie

Year: 2020

Venue: University of Guelph

DOI: https://hdl.handle.net/10214/21780

Thesis Characterization of excipients for their application during purification of monoclonal antibodies and other therapeutic proteins

Stange, Carolin · 2023 · Heidelberg University · DOI

Full title: Characterization of excipients for their application during purification of monoclonal antibodies and other therapeutic proteins

Authors: Stange, Carolin

Year: 2023

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/33181/1/Dissertation_Carolin%20Stange.pdf

Thesis Separation and characterization of antibody-based protein variants in column chromatography for the production of biopharmaceuticals

Sanchez Reyes, Gabriela · 2022 · Heidelberg University · DOI

Full title: Separation and characterization of antibody-based protein variants in column chromatography for the production of biopharmaceuticals

Authors: Sanchez Reyes, Gabriela

Year: 2022

Venue: Heidelberg University

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/30762/1/Dissertation_Sanchez%20Reyes%20Gabriela_FINAL.pdf

Thesis Biosynthetic isotopic labelling strategies for the production of membrane proteins for solid-state Nuclear Magnetic Resonance spectroscopy

Munro, Rachel · 2021 · University of Guelph · DOI

Full title: Biosynthetic isotopic labelling strategies for the production of membrane proteins for solid-state Nuclear Magnetic Resonance spectroscopy

Authors: Munro, Rachel

Year: 2021

Venue: University of Guelph

DOI: https://hdl.handle.net/10214/23722

Thesis Recombinant Production of Growth Factors and Antimicrobial Peptides Using Microorganisms to Modulate Tissue Damage Healing

Huynh, Evanna · 2016 · University of Guelph · DOI

Full title: Recombinant Production of Growth Factors and Antimicrobial Peptides Using Microorganisms to Modulate Tissue Damage Healing

Authors: Huynh, Evanna

Year: 2016

Venue: University of Guelph

DOI: http://hdl.handle.net/10214/9445

Thesis Solid Binding Peptides: Applications in Affinity Protein Purification and Bioprotonic Devices

Soto-Rodriguez, Jessica · 2019 · University of Washington - ResearchWorks · DOI

Full title: Solid Binding Peptides: Applications in Affinity Protein Purification and Bioprotonic Devices

Authors: Soto-Rodriguez, Jessica

Year: 2019

Venue: University of Washington - ResearchWorks

DOI: http://hdl.handle.net/1773/43321

Thesis Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022 · KTH Royal Institute of Technology · DOI

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

Year: 2022

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis Interaction engineered three-helix bundle domains for protein recovery and detection

Alm, Tove · 2010 · KTH Royal Institute of Technology · DOI

Full title: Interaction engineered three-helix bundle domains for protein recovery and detection

Authors: Alm, Tove

Year: 2010

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-12823

Thesis Characterization of Antigenic Properties and High Throughput Protein Purification

Steen, Johanna · 2010 · KTH Royal Institute of Technology · DOI

Full title: Characterization of Antigenic Properties and High Throughput Protein Purification

Authors: Steen, Johanna

Year: 2010

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-25841

Thesis Calcium-dependent Affinity Domains for the Purification of Antibodies and Antibody Fragments

Scheffel, Julia · 2022 · KTH Royal Institute of Technology · DOI

Full title: Calcium-dependent Affinity Domains for the Purification of Antibodies and Antibody Fragments

Authors: Scheffel, Julia

Year: 2022

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-309572

Thesis Engineering Proteinaceous Ligands for Improved Performance in Affinity Chromatography Applications

Gülich, Susanne · 2002 · KTH Royal Institute of Technology · DOI

Full title: Engineering Proteinaceous Ligands for Improved Performance in Affinity Chromatography Applications

Authors: Gülich, Susanne

Year: 2002

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3327

Thesis Magnetic bead-based isolation of biological therapeutic modalities

Brechmann, Nils A. · 2022 · KTH Royal Institute of Technology · DOI

Full title: Magnetic bead-based isolation of biological therapeutic modalities

Authors: Brechmann, Nils A.

Year: 2022

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-321336

Thesis Strategies for facilitated protein recovery after recombinant production in Escherichia coli

Hedhammar, My · 2005 · KTH Royal Institute of Technology · DOI

Full title: Strategies for facilitated protein recovery after recombinant production in Escherichia coli

Authors: Hedhammar, My

Year: 2005

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-471

Thesis Protein engineering to explore and improve affinity ligands

Linhult, Martin · 2003 · KTH Royal Institute of Technology · DOI

Full title: Protein engineering to explore and improve affinity ligands

Authors: Linhult, Martin

Year: 2003

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3632

Thesis Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Hong, Moo Sun · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Authors: Hong, Moo Sun

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/138943

Thesis Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Maloney, Andrew John · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Authors: Maloney, Andrew John

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/158315

Thesis Characterization and application of vortex flow adsorption for simplification of biochemical product downstream processing

Ma, Junfen, 1972- · 2005 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Characterization and application of vortex flow adsorption for simplification of biochemical product downstream processing

Authors: Ma, Junfen, 1972-

Year: 2005

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/17010

Thesis Purification of recombinant proteins with magnetic nanoclusters

Ditsch, Andre (Andre Paul) · 2006 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Purification of recombinant proteins with magnetic nanoclusters

Authors: Ditsch, Andre (Andre Paul)

Year: 2006

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/34160

Thesis Creating an Efficient Biopharmaceutical Factory: Protein Expression and Purification Using a Self-Cleaving Split Intein

Cooper, Merideth A. · 2018 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Creating an Efficient Biopharmaceutical Factory: Protein Expression and Purification Using a Self-Cleaving Split Intein

Authors: Cooper, Merideth A.

Year: 2018

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu152226172238882

Thesis Developing Molecular Tools for Applications in Metabolic Engineering and ProteinPurification

lahiry, ashwin · 2017 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Developing Molecular Tools for Applications in Metabolic Engineering and ProteinPurification

Authors: lahiry, ashwin

Year: 2017

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1502109789024711

Thesis Utilizing Commercially Scalable Methods for Isolating and Generating Bioactive Compounds from Bovine Dairy Byproducts

Tam, Andrea Jiabao Chao · 2023 · University of California, Davis · DOI

Full title: Utilizing Commercially Scalable Methods for Isolating and Generating Bioactive Compounds from Bovine Dairy Byproducts

Authors: Tam, Andrea Jiabao Chao

Year: 2023

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/1h52p8pz

Thesis Solid Substrate for High Throughput Protein Chromatography

Alvarez, Adrian · 2018 · University of California, San Diego (UCSD) · DOI

Full title: Solid Substrate for High Throughput Protein Chromatography

Authors: Alvarez, Adrian

Year: 2018

Venue: University of California, San Diego (UCSD)

DOI: https://escholarship.org/uc/item/7hd470qf

Thesis Plant Molecular Pharming Techno-Economic and Virus-Based Nanomaterial Approaches to Limited Resource Recombinant Protein Manufacturing

McNulty, Matthew · 2022 · University of California, Davis · DOI

Full title: Plant Molecular Pharming Techno-Economic and Virus-Based Nanomaterial Approaches to Limited Resource Recombinant Protein Manufacturing

Authors: McNulty, Matthew

Year: 2022

Venue: University of California, Davis

DOI: https://escholarship.org/uc/item/66w9s6ht

Thesis Scalable Purification of Ultra-Pure Lumbricus terrestris Mega-Hemoglobin and Surface Modification using Bio-compatible Polymers for use as an Oxygen Therapeutic

Savla, Chintan · 2023 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Scalable Purification of Ultra-Pure Lumbricus terrestris Mega-Hemoglobin and Surface Modification using Bio-compatible Polymers for use as an Oxygen Therapeutic

Authors: Savla, Chintan

Year: 2023

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1681905710885225

Thesis Split Intein Applications for Downstream Purification and Protein Conjugation

Galiardi, Jackelyn · 2021 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Split Intein Applications for Downstream Purification and Protein Conjugation

Authors: Galiardi, Jackelyn

Year: 2021

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1618931990774251

Thesis Split Inteins As Versatile Tools in Applications of Downstream Purification and Bioconjugation

Fan, Yamin · 2019 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Split Inteins As Versatile Tools in Applications of Downstream Purification and Bioconjugation

Authors: Fan, Yamin

Year: 2019

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu155508523693651

Thesis Control of Intein-Mediated Self-Cleaving Tag for Recombinant Protein Purification

Han, Tzu-Chiang · 2016 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Control of Intein-Mediated Self-Cleaving Tag for Recombinant Protein Purification

Authors: Han, Tzu-Chiang

Year: 2016

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1453206997

Thesis Recent Advances in Developing Molecular Biotechnology Tools for Metabolic Engineering and Recombinant Protein Purification

Stimple, Samuel Douglas · 2018 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Recent Advances in Developing Molecular Biotechnology Tools for Metabolic Engineering and Recombinant Protein Purification

Authors: Stimple, Samuel Douglas

Year: 2018

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1514494485801145

Thesis Advances in affinity-based methods for downstream process development of monoclonal antibody and recombinant protein therapeutics

Prabhala, Sai Vivek · 2023 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Advances in affinity-based methods for downstream process development of monoclonal antibody and recombinant protein therapeutics

Authors: Prabhala, Sai Vivek

Year: 2023

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1700243307178593

Thesis Development of a Novel Intein-Mediated Affinity Capture Platform for Production of Recombinant Proteins and Biopharmaceuticals

Taris, Joseph Edward · 2021 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Development of a Novel Intein-Mediated Affinity Capture Platform for Production of Recombinant Proteins and Biopharmaceuticals

Authors: Taris, Joseph Edward

Year: 2021

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu163853540249581

Thesis Multi-stage Aqueous Two-Phase Extraction

Chandler, Emma · 2021 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Multi-stage Aqueous Two-Phase Extraction

Authors: Chandler, Emma

Year: 2021

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/29388/1/Multi-stage%20Aqueous%20Two-Phase%20Extraction.pdf

Thesis The affinity precipitation for the isolation of biomolecules

Stocker Majd, Gisela · 2007 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: The affinity precipitation for the isolation of biomolecules

Authors: Stocker Majd, Gisela

Year: 2007

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7866

Thesis Evaluating Improvements and Challenges in Affinity Chromatography for AAV Purification

Dachenko, Alexandra · 2023 · Johns Hopkins University · DOI

Full title: Evaluating Improvements and Challenges in Affinity Chromatography for AAV Purification

Authors: Dachenko, Alexandra

Year: 2023

Venue: Johns Hopkins University

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/69011

Thesis Bioprocess development: extraction and purification of human serum albumin from transgenic rice

Sheshukova, Kseniya Alekseyevna · 2019 · Kansas State University - K-REx · DOI

Full title: Bioprocess development: extraction and purification of human serum albumin from transgenic rice

Authors: Sheshukova, Kseniya Alekseyevna

Year: 2019

Venue: Kansas State University - K-REx

DOI: http://hdl.handle.net/2097/39681

Thesis Design and Control of Integrated Continuous Processes for the Purification of Biopharmaceuticals

Gomis Fons, Joaquin · 2022 · Lund University (LUP) · DOI

Full title: Design and Control of Integrated Continuous Processes for the Purification of Biopharmaceuticals

Authors: Gomis Fons, Joaquin

Year: 2022

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/7de201f7-6a1b-4772-b3d1-e5d221e9515c

Thesis Antibody-Fragments: Protein Engineering, Process Development, and their Application as Affinity Ligands

Sakhnini, Laila · 2019 · Lund University (LUP) · DOI

Full title: Antibody-Fragments: Protein Engineering, Process Development, and their Application as Affinity Ligands

Authors: Sakhnini, Laila

Year: 2019

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/3156874d-3d8d-41ad-bd7a-6be6ffb8e037

Thesis Developing integrated downstream processes for next-generation biologics

Löfgren, Anton · 2020 · Lund University (LUP) · DOI

Full title: Developing integrated downstream processes for next-generation biologics

Authors: Löfgren, Anton

Year: 2020

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/31772706-1f08-4ef5-b61e-db17291cd22b

Thesis CUSTOMIZED QUANTIFICATION OF HOST CELL PROTEIN WITH BIO-LAYER INTERFEROMETRY

Sjöblom, Eva · 2020 · Lund University Student Papers · DOI

Full title: CUSTOMIZED QUANTIFICATION OF HOST CELL PROTEIN WITH BIO-LAYER INTERFEROMETRY

Authors: Sjöblom, Eva

Year: 2020

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9032572

Thesis Composite Cryogels: Stationary Phase for Separation of Complex Media

Hajizadeh, Solmaz · 2012 · Lund University (LUP) · DOI

Full title: Composite Cryogels: Stationary Phase for Separation of Complex Media

Authors: Hajizadeh, Solmaz

Year: 2012

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/3165833

Thesis Cryogels as Solid Supports in Bioprocessing

Jespersen, Gry · 2014 · Lund University (LUP) · DOI

Full title: Cryogels as Solid Supports in Bioprocessing

Authors: Jespersen, Gry

Year: 2014

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/4318450

Thesis Orbit-simulator for downstream processes

Malmström, Andreas · 2022 · Lund University Student Papers · DOI

Full title: Orbit-simulator for downstream processes

Authors: Malmström, Andreas

Year: 2022

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/9077663

Thesis Matrix-assisted protein refolding

Dashivets, Tetyana · 2015 · Technical University of Munich · DOI

Full title: Matrix-assisted protein refolding

Authors: Dashivets, Tetyana

Year: 2015

Venue: Technical University of Munich

DOI: https://mediatum.ub.tum.de/1087053

Thesis Integrated Continuous Downstream Processing of Biopharmaceuticals

Isaksson, Madelène · 2025 · Lund University (LUP) · DOI

Full title: Integrated Continuous Downstream Processing of Biopharmaceuticals

Authors: Isaksson, Madelène

Year: 2025

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/30d11714-b846-42b4-8361-67da8137b563

Thesis Protein Crystallization in Stirred-Tank Reactors

Hebel, Dirk Peter · 2013 · Technical University of Munich · DOI

Full title: Protein Crystallization in Stirred-Tank Reactors

Authors: Hebel, Dirk Peter

Year: 2013

Venue: Technical University of Munich

DOI: https://mediatum.ub.tum.de/1115472

Thesis Enrichment Behavior of Immunoglobulin by Foam Fractionation Using Response Surface Methodology

Chen, Yen-Chih · 2018 · Technical University of Munich · DOI

Full title: Enrichment Behavior of Immunoglobulin by Foam Fractionation Using Response Surface Methodology

Authors: Chen, Yen-Chih

Year: 2018

Venue: Technical University of Munich

DOI: https://mediatum.ub.tum.de/1083287

Thesis Fractionation of major and minor Whey Proteins using Membrane-based Ion-exchange Chromatography

Voswinkel, Linda Elisabeth · 2017 · Technical University of Munich · DOI

Full title: Fractionation of major and minor Whey Proteins using Membrane-based Ion-exchange Chromatography

Authors: Voswinkel, Linda Elisabeth

Year: 2017

Venue: Technical University of Munich

DOI: https://mediatum.ub.tum.de/1292689

Thesis Membrane adsorbers and novel affinity peptides for recombinant protein purification

Weaver, Justin, author; Wickramasinghe, S. Ranil, advisor; Qian, Xianghong, committee member et al. · 2015 · Colorado State University · DOI

Full title: Membrane adsorbers and novel affinity peptides for recombinant protein purification

Authors: Weaver, Justin, author; Wickramasinghe, S. Ranil, advisor; Qian, Xianghong, committee member; Carlson, Jon O., committee member; Bailey, Travis S., committee member

Year: 2015

Venue: Colorado State University

DOI: http://hdl.handle.net/10217/166862

Thesis Production of a SARS-CoV-2 Spike Protein Vaccine Using the Baculovirus Expression Vector System

Adler, Rachel; Kelsey, Nathan; Maik, Michelle et al. · 2023 · University of Pennsylvania · DOI

Full title: Production of a SARS-CoV-2 Spike Protein Vaccine Using the Baculovirus Expression Vector System

Authors: Adler, Rachel; Kelsey, Nathan; Maik, Michelle; Song, Jun Ho

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/5955

Thesis Optimization of Oleosin 30G Production for Echocardiography

Krysiewicz, Annette; Parsons, Andrew; Rodriguez-Labra, Sergio · 2023 · University of Pennsylvania · DOI

Full title: Optimization of Oleosin 30G Production for Echocardiography

Authors: Krysiewicz, Annette; Parsons, Andrew; Rodriguez-Labra, Sergio

Year: 2023

Venue: University of Pennsylvania

DOI: https://repository.upenn.edu/handle/20.500.14332/6054

Thesis Design of bacterial polyester beads for recombinant protein production, biomolecule separation and detection : a thesis presented in partial fulfilment of the requirements of the degree of Doctor of Philosophy in Microbiology at Massey University, Palmerston North, New Zealand

Du, Jinping · 2020 · Massey University · DOI

Full title: Design of bacterial polyester beads for recombinant protein production, biomolecule separation and detection : a thesis presented in partial fulfilment of the requirements of the degree of Doctor of Philosophy in Microbiology at Massey University, Palmerston North, New Zealand

Authors: Du, Jinping

Year: 2020

Venue: Massey University

DOI: http://hdl.handle.net/10179/15326

Thesis Heterologous expression of rat ST6Gal-I in Pichia pastoris for structural and functional studies

Tejwani, Narendra Gurnamal · 2024 · University of Georgia - UGA Open Scholar · DOI

Full title: Heterologous expression of rat ST6Gal-I in Pichia pastoris for structural and functional studies

Authors: Tejwani, Narendra Gurnamal

Year: 2024

Venue: University of Georgia - UGA Open Scholar

DOI: https://openscholar.uga.edu/record/13452/files/tejwani_narendra_g_200812_phd.pdf

Thesis Expression, purification and characterisation of antimicrobial peptides of human and bovine lactoferrins : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, Palmerston North, New Zealand

Rallabhandi, Venkata Siva Prasad Sarma · 2012 · Massey University · DOI

Full title: Expression, purification and characterisation of antimicrobial peptides of human and bovine lactoferrins : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, Palmerston North, New Zealand

Authors: Rallabhandi, Venkata Siva Prasad Sarma

Year: 2012

Venue: Massey University

DOI: http://hdl.handle.net/10179/3608

Thesis Efficiency of two cation exchange methods for isolating lactoperoxidase and lactoferrin from Gouda and Cheddar cheese whey

· 2013 · University of Pretoria · DOI

Full title: Efficiency of two cation exchange methods for isolating lactoperoxidase and lactoferrin from Gouda and Cheddar cheese whey

Year: 2013

Venue: University of Pretoria

DOI: http://hdl.handle.net/2263/29897

Thesis Protein Recovery from Potato Processing Effluent Stream Using Ultrafiltration Membrane

Dabestani, Shirin Sadat · 2017 · UNSW Sydney · DOI

Full title: Protein Recovery from Potato Processing Effluent Stream Using Ultrafiltration Membrane

Authors: Dabestani, Shirin Sadat

Year: 2017

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/58525

Thesis Purification of an acidic recombinant protein from transgenic tobacco

Holler, Christopher J. · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Purification of an acidic recombinant protein from transgenic tobacco

Authors: Holler, Christopher J.

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/32379

Thesis Downstream processing of recombinant and endogenous proteins from livestock milk

Degener, Arthur W. Jr. · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Downstream processing of recombinant and endogenous proteins from livestock milk

Authors: Degener, Arthur W. Jr.

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/27183

Thesis Optimization of the production of recombinant macrophage inhibitory cytokine 1 (MIC-1) from Pichia pastoris

Pratanaphon, Ronachai · 2006 · UNSW Sydney · DOI

Full title: Optimization of the production of recombinant macrophage inhibitory cytokine 1 (MIC-1) from Pichia pastoris

Authors: Pratanaphon, Ronachai

Year: 2006

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/68401

Thesis Purification of the major envelope protein GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) from native virions

Matanin, Brad Matthew · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Purification of the major envelope protein GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) from native virions

Authors: Matanin, Brad Matthew

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/33194

Thesis Design of anion exchange cellulose hydrogel for large proteins

Kumar, Guneet · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Design of anion exchange cellulose hydrogel for large proteins

Authors: Kumar, Guneet

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/38250

Thesis Technology development for the over-expression, purification and crystallisation of human membrane proteins

Young, Gillian · 2011 · University of Glasgow · DOI

Full title: Technology development for the over-expression, purification and crystallisation of human membrane proteins

Authors: Young, Gillian

Year: 2011

Venue: University of Glasgow

DOI: https://theses.gla.ac.uk/2539/1/2010YoungPhD.pdf

Thesis Antibody Purification from Tobacco by Protein A Affinity Chromatography

Hey, Carolyn McKenzie · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Antibody Purification from Tobacco by Protein A Affinity Chromatography

Authors: Hey, Carolyn McKenzie

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/42645

Thesis Production of native flagellin from Salmonella Typhimurium in a bioreactor and purification by tangential ultrafiltration

Takagi, M. · 2011 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Production of native flagellin from Salmonella Typhimurium in a bioreactor and purification by tangential ultrafiltration

Authors: Takagi, M.

Year: 2011

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.1590/s0104-66322011000400003

Thesis Applications of recombinant Pichia pastoris in the healthcare industry

Farías, Jorge G · 2013 · Universidade de São Paulo – USP Digital Library · DOI

Full title: Applications of recombinant Pichia pastoris in the healthcare industry

Authors: Farías, Jorge G

Year: 2013

Venue: Universidade de São Paulo – USP Digital Library

DOI: http://www.scielo.br/pdf/bjm/v44n4/04.pdf

Thesis Evaluation of Phenomena that Determine the Performance of Immunoaffinity, Peptide-Based and Ion Exchange Affinity Sorbents

Sines, Brian James · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Evaluation of Phenomena that Determine the Performance of Immunoaffinity, Peptide-Based and Ion Exchange Affinity Sorbents

Authors: Sines, Brian James

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/29841

Thesis Identification of the factors impacting immunosorbent performance

Subramanian, Anuradha · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Identification of the factors impacting immunosorbent performance

Authors: Subramanian, Anuradha

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/38450

Thesis Microcapillary membranes for purification of biomolecules

Mandal, Ipshita · 2016 · University of Cambridge · DOI

Full title: Microcapillary membranes for purification of biomolecules

Authors: Mandal, Ipshita

Year: 2016

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/255867

Thesis Separation of Recombinant β-Glucuronidase from Transgenic Tobacco by Aqueous Two-Phase Extraction

Ross, Kristin Coby · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Separation of Recombinant β-Glucuronidase from Transgenic Tobacco by Aqueous Two-Phase Extraction

Authors: Ross, Kristin Coby

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/43471

Thesis A step forward in recombinant protein production regulated by the constitutive GAP promoter in Pichia pastoris through bioprocess engineering approaches

Garcia Ortega, Xavier · 2016 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: A step forward in recombinant protein production regulated by the constitutive GAP promoter in Pichia pastoris through bioprocess engineering approaches

Authors: Garcia Ortega, Xavier

Year: 2016

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://hdl.handle.net/10803/384531

Thesis L-Asparaginase from Penicillium sizovae produced by a recombinant Komagataella phaffii strain

Pérola O. Magalhães · 2022 · Universidade de São Paulo – USP Digital Library · DOI

Full title: L-Asparaginase from Penicillium sizovae produced by a recombinant Komagataella phaffii strain

Authors: Pérola O. Magalhães

Year: 2022

Venue: Universidade de São Paulo – USP Digital Library

DOI: https://doi.org/10.3390/ph15060746

Thesis Expression and Mutagenesis studies of Candida antactica lipase B

Rotticci-Mulder, Johanna C. · 2003 · KTH Royal Institute of Technology · DOI

Full title: Expression and Mutagenesis studies of Candida antactica lipase B

Authors: Rotticci-Mulder, Johanna C.

Year: 2003

Venue: KTH Royal Institute of Technology

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3493

Thesis Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties

Nordin, Joel Z.; Lee, Yi; Vader, Pieter et al. · 2015 · Utrecht University · DOI

Full title: Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties

Authors: Nordin, Joel Z.; Lee, Yi; Vader, Pieter; Mäger, Imre; Johansson, Henrik J.; Heusermann, Wolf; Wiklander, Oscar P B; Hällbrink, Mattias; Seow, Yiqi; Bultema, Jarred J.; Gilthorpe, Jonathan; Davies, Tim; Fairchild, Paul J.; Gbrielsson, Susanne; Meisner-Kober, Nicole C.; Lehtiö, Janne; Smith, C. I Edvard; Wood, Matthew J A; Andaloussi, Samir E L

Year: 2015

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/332511

Thesis Going native: Complete removal of protein purification affinity tags by simple modification of existing tags and proteases

Goh, Hui Chin; Sobota, Radoslaw M.; Ghadessy, Farid J. et al. · 2017 · Nanyang Technological University (NTU) · DOI

Full title: Going native: Complete removal of protein purification affinity tags by simple modification of existing tags and proteases

Authors: Goh, Hui Chin; Sobota, Radoslaw M.; Ghadessy, Farid J.; Nirantar, Saurabh

Year: 2017

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/83191

Thesis Optimized protocol for expression and purification of membrane-bound PglB, a bacterial oligosaccharyl transferase

Jaffee, Marcie Beth; Imperiali, Barbara · 2017 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Optimized protocol for expression and purification of membrane-bound PglB, a bacterial oligosaccharyl transferase

Authors: Jaffee, Marcie Beth; Imperiali, Barbara

Year: 2017

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/110397

Thesis Rapid Developability Assessments to Formulate Recombinant Protein Antigens as Stable, Low-Cost, Multi-Dose Vaccine Candidates: Case-Study With Non-Replicating Rotavirus (NRRV) Vaccine Antigens

Sawant, Nishant; Kaur, Kawaljit; Holland, David A et al. · 2021 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Rapid Developability Assessments to Formulate Recombinant Protein Antigens as Stable, Low-Cost, Multi-Dose Vaccine Candidates: Case-Study With Non-Replicating Rotavirus (NRRV) Vaccine Antigens

Authors: Sawant, Nishant; Kaur, Kawaljit; Holland, David A; Hickey, John M; Agarwal, Sanjeev; Brady, Joseph R; Dalvie, Neil C; Tracey, Mary Kate; Velez-Suberbie, M Lourdes; Morris, Stephen A; Jacob, Shaleem I; Bracewell, Daniel G; Mukhopadhyay, Tarit K; Love, Kerry R; Love, J Christopher; Joshi, Sangeeta B; Volkin, David B

Year: 2021

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/134368

Thesis Data concerning the chromatographic isolation of bovine IgG from milk- and colostral whey

Heidebrecht, Hans-Jürgen; Kainz, Bernadette; Schopf, Roland et al. · 2018 · Utrecht University · DOI

Full title: Data concerning the chromatographic isolation of bovine IgG from milk- and colostral whey

Authors: Heidebrecht, Hans-Jürgen; Kainz, Bernadette; Schopf, Roland; Godl, Klaus; Karcier, Züleyha; Kulozik, Ulrich; Förster, Beatrix

Year: 2018

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/384260

Thesis Isolation of biofunctional bovine immunoglobulin G from milk- and colostral whey with mixed-mode chromatography at lab and pilot scale

Heidebrecht, Hans-Jürgen; Kainz, Bernadette; Schopf, Roland et al. · 2018 · Utrecht University · DOI

Full title: Isolation of biofunctional bovine immunoglobulin G from milk- and colostral whey with mixed-mode chromatography at lab and pilot scale

Authors: Heidebrecht, Hans-Jürgen; Kainz, Bernadette; Schopf, Roland; Godl, Klaus; Karcier, Züleyha; Kulozik, Ulrich; Förster, Beatrix

Year: 2018

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/384261

Thesis On-demand manufacturing of clinical-quality biopharmaceuticals

Crowell, Laura E; Lu, Amos E; Love, Kerry R et al. · 2021 · Massachusetts Institute of Technology (MIT) · DOI

Full title: On-demand manufacturing of clinical-quality biopharmaceuticals

Authors: Crowell, Laura E; Lu, Amos E; Love, Kerry R; Stockdale, Alan; Timmick, Steven M; Wu, Di; Wang, Yu Annie; Doherty, William; Bonnyman, Alexandra; Vecchiarello, Nicholas; Goodwine, Chaz; Bradbury, Lisa; Brady, Joseph R; Clark, John J; Colant, Noelle A; Cvetkovic, Aleksandar; Dalvie, Neil C; Liu, Diana; Liu, Yanjun; Mascarenhas, Craig A; Matthews, Catherine B; Mozdzierz, Nicholas J; Shah, Kartik A; Wu, Shiaw-Lin; Hancock, William S; Braatz, Richard D; Cramer, Steven M; Love, J Christopher

Year: 2021

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/134719

Thesis Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care

Cleto, Sara; Lee, Kevin; Perez-Pinera, Pablo et al. · 2017 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care

Authors: Cleto, Sara; Lee, Kevin; Perez-Pinera, Pablo; Han, Ningren; Cao, Jicong; Purcell, Oliver; Shah, Kartik A; Ram, Rajeev J; Lu, Timothy K

Year: 2017

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/109076

Thesis Versatile and on-demand biologics co-production in yeast

Cao, Jicong; Perez-Pinera, Pablo; Lowenhaupt, Ky et al. · 2018 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Versatile and on-demand biologics co-production in yeast

Authors: Cao, Jicong; Perez-Pinera, Pablo; Lowenhaupt, Ky; Wu, Ming-Ru; Purcell, Oliver; de la Fuente-Nunez, Cesar; Lu, Timothy K.; de la Fuente Nunez, Cesar; Lu, Timothy K

Year: 2018

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/115215

Thesis Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus

Dalvie, Neil C; Brady, Joseph R; Crowell, Laura E et al. · 2021 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus

Authors: Dalvie, Neil C; Brady, Joseph R; Crowell, Laura E; Tracey, Mary K; Biedermann, Andrew M; Kaur, Kawaljit; Hickey, John M; Kristensen, D. L; Bonnyman, Alexandra D; Rodriguez-Aponte, Sergio A; Whittaker, Charles A; Bok, Marina; Vega, Celina; Mukhopadhyay, Tarit K; Joshi, Sangeeta B; Volkin, David B

Year: 2021

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/136780

Thesis Rapid optimization of processes for the integrated purification of biopharmaceuticals

Crowell, Laura E; Rodriguez, Sergio A; Love, Kerry R et al. · 2021 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Rapid optimization of processes for the integrated purification of biopharmaceuticals

Authors: Crowell, Laura E; Rodriguez, Sergio A; Love, Kerry R; Cramer, Steven M; Love, J Christopher

Year: 2021

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/135519

Thesis Understanding electrostatic interaction on strong cation-exchanger via co-ion valency effects

Essert, GM; de Souza, JP; Schwaminger, SP et al. · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Understanding electrostatic interaction on strong cation-exchanger via co-ion valency effects

Authors: Essert, GM; de Souza, JP; Schwaminger, SP; Bazant, MZ; Berensmeier, S

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/157408

Thesis Purification of recombinant proteins

Rutt, George Clifford · 2008 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Purification of recombinant proteins

Authors: Rutt, George Clifford

Year: 2008

Venue: Massachusetts Institute of Technology (MIT)

DOI: http://hdl.handle.net/1721.1/42614

Thesis DESIGN OF RECOMBINANT TENEBRIO MOLITOR ANTIFREEZE PROTEIN FOR PURIFICATION USING ELASTIN-LIKE POLYPEPTIDE TAG

OH, JOONGSEOK · 2014 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: DESIGN OF RECOMBINANT TENEBRIO MOLITOR ANTIFREEZE PROTEIN FOR PURIFICATION USING ELASTIN-LIKE POLYPEPTIDE TAG

Authors: OH, JOONGSEOK

Year: 2014

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=csu1409230499

Thesis Scale-up of affinity chromatography for protein purifications

Hsu, Kuang-Hsin · 2000 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Scale-up of affinity chromatography for protein purifications

Authors: Hsu, Kuang-Hsin

Year: 2000

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1172002240

Thesis Column-free Purification Method for Recombinant Proteins Using a Self-Cleaving Aggregating tag

Miozzi, Jackelyn · 2018 · OhioLINK Electronic Theses and Dissertations · DOI

Full title: Column-free Purification Method for Recombinant Proteins Using a Self-Cleaving Aggregating tag

Authors: Miozzi, Jackelyn

Year: 2018

Venue: OhioLINK Electronic Theses and Dissertations

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu15229401048581

Thesis Purifikace rekombinantních proteinů pomocí afinitní chromatografie

Zemek, Ondřej · 2017 · Charles University Prague (Univerzita Karlova) · DOI

Full title: Purifikace rekombinantních proteinů pomocí afinitní chromatografie

Authors: Zemek, Ondřej

Year: 2017

Venue: Charles University Prague (Univerzita Karlova)

DOI: http://hdl.handle.net/20.500.11956/39620

Thesis Human granulocyte colony stimulating factor (hG-CSF): cloning, overexpression, purification and characterization

Vanz, Ana L. S.; Renard, Gaby; Palma, Mario Sergio [UNESP] et al. · 2014 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Human granulocyte colony stimulating factor (hG-CSF): cloning, overexpression, purification and characterization

Authors: Vanz, Ana L. S.; Renard, Gaby; Palma, Mario Sergio [UNESP]; Chies, Jocelei M.; Dalmora, Sergio L.; Basso, Luiz A.; Santos, Diogenes S.

Year: 2014

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1186/1475-2859-7-13

Thesis Synthesis of human bone morphogenetic protein-2 (Hbmp-2) in e. coli periplasmic space: its characterization and preclinical testing

Oliveira, João E.; Suzuki, Miriam F.; Damiani, Renata et al. · 2022 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Synthesis of human bone morphogenetic protein-2 (Hbmp-2) in e. coli periplasmic space: its characterization and preclinical testing

Authors: Oliveira, João E.; Suzuki, Miriam F.; Damiani, Renata; Lima, Eliana R.; Amaral, Kleicy C.; Santos, Anderson M. S. [UNESP]; Magalhães, Geraldo S.; Faverani, Leonardo P. [UNESP]; Pereira, Luís A. V. D.; Bartolini, Paolo

Year: 2022

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.3390/cells10123525

Thesis Avaliação teórica da separação de xilanase produzida por Escherichia coli a partir dos processos de filtração e centrifugação com uso de floculante

Fuzaro, Maria Claudia Correia [UNESP] · 2025 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Avaliação teórica da separação de xilanase produzida por Escherichia coli a partir dos processos de filtração e centrifugação com uso de floculante

Authors: Fuzaro, Maria Claudia Correia [UNESP]

Year: 2025

Venue: Universidade Estadual Paulista (UNESP)

DOI: https://hdl.handle.net/11449/311794

Thesis HPLC for at-line reaction monitoring and purification improves yield and purity of tRNA

Megušar, Polona; Calder, Ewen; Vodopivec Seravalli, Tina et al. · 2024 · Imperial College London · DOI

Full title: HPLC for at-line reaction monitoring and purification improves yield and purity of tRNA

Authors: Megušar, Polona; Calder, Ewen; Vodopivec Seravalli, Tina; Lebar, Sergeja; Walport, Louise; Sekirnik, Rok

Year: 2024

Venue: Imperial College London

DOI: https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2024.1443917/abstract

Thesis Insight into purification of monoclonal antibodies in industrial columns via studies of Protein A binding capacity by in situ ATR-FTIR spectroscopy

Beattie, james; Rowland-Jones, Ruth; Farys, Monika et al. · 2021 · Imperial College London · DOI

Full title: Insight into purification of monoclonal antibodies in industrial columns via studies of Protein A binding capacity by in situ ATR-FTIR spectroscopy

Authors: Beattie, james; Rowland-Jones, Ruth; Farys, Monika; Kucia-Tran, Richard; Kazarian, Sergei; Byrne, Bernadette

Year: 2021

Venue: Imperial College London

DOI: https://pubs.rsc.org/en/content/articlelanding/2021/AN/D1AN00985K

Thesis Lysozyme Separation from Tobacco Extract by Aqueous Two-Phase Extraction

Balasubramaniam, Deepa · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Lysozyme Separation from Tobacco Extract by Aqueous Two-Phase Extraction

Authors: Balasubramaniam, Deepa

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/31272

Thesis Monoclonal Antibody Expression and Novel Purification in Nicotiana benthamiana

Fulton, Andrew Dale · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Monoclonal Antibody Expression and Novel Purification in Nicotiana benthamiana

Authors: Fulton, Andrew Dale

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/43361

Thesis Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris.

Whyteside, Graham; Alcocer, Marcos JC; Kumita, Janet R et al. · 2020 · University of Cambridge · DOI

Full title: Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris.

Authors: Whyteside, Graham; Alcocer, Marcos JC; Kumita, Janet R; Dobson, Christopher M; Lazarou, Maria; Pleass, Richard J; Archer, David B

Year: 2020

Venue: University of Cambridge

DOI: https://www.repository.cam.ac.uk/handle/1810/309386

Thesis Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel et al. · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Authors: Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel; Dang, Brendan; Wolffe, Lenna A; Atari, Adel; Tseng, Yuen-Yi; Love, J Christopher

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/163220

Thesis Enhancing Protein Crystal Nucleation Using In Situ Templating on Bioconjugate-Functionalized Nanoparticles and Machine Learning

McCue, Caroline; Girard, Henri-Louis; Varanasi, Kripa K. · 2024 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Enhancing Protein Crystal Nucleation Using In Situ Templating on Bioconjugate-Functionalized Nanoparticles and Machine Learning

Authors: McCue, Caroline; Girard, Henri-Louis; Varanasi, Kripa K.

Year: 2024

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/154924

Thesis Development of an integrated platform for the production of recombinant biopharmaceuticals

Segarra, Camille · 2013 · White Rose eTheses (Leeds, Sheffield, York) · DOI

Full title: Development of an integrated platform for the production of recombinant biopharmaceuticals

Authors: Segarra, Camille

Year: 2013

Venue: White Rose eTheses (Leeds, Sheffield, York)

DOI: https://etheses.whiterose.ac.uk/id/eprint/4147/1/Segarra_Thesis_PostCorrections.pdf

Thesis Purification and biodistribution of extracellular vesicles

Joel Nordin (18664774) · 2017 · Karolinska Institutet · DOI

Full title: Purification and biodistribution of extracellular vesicles

Authors: Joel Nordin (18664774)

Year: 2017

Venue: Karolinska Institutet

DOI: oai:figshare.com:article/26912188

Thesis Primary Recovery of Biologically Active Compounds Using Macroporous Monolithic Hydrogels

Hanora, Amro · 2005 · Lund University (LUP) · DOI

Full title: Primary Recovery of Biologically Active Compounds Using Macroporous Monolithic Hydrogels

Authors: Hanora, Amro

Year: 2005

Venue: Lund University (LUP)

DOI: https://lup.lub.lu.se/record/545390

Thesis Downstream purification and analysis of the recombinant human myelin basic protein produced in the milk of transgenic cows : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Chemistry, Massey University (Palmerston North) New Zealand.

Al-Ghobashy, Medhat Ahmed Abdel-Hamid · 2010 · Massey University · DOI

Full title: Downstream purification and analysis of the recombinant human myelin basic protein produced in the milk of transgenic cows : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Chemistry, Massey University (Palmerston North) New Zealand.

Authors: Al-Ghobashy, Medhat Ahmed Abdel-Hamid

Year: 2010

Venue: Massey University

DOI: http://hdl.handle.net/10179/1186

Thesis Partitioning behaviours and selective recovery of therapeutic protein in aqueous two-phase system

Chow, Yin Hui · 2016 · Universiti Putra Malaysia (PSAS IR) · DOI

Full title: Partitioning behaviours and selective recovery of therapeutic protein in aqueous two-phase system

Authors: Chow, Yin Hui

Year: 2016

Venue: Universiti Putra Malaysia (PSAS IR)

DOI: http://psasir.upm.edu.my/id/eprint/70219/1/FK%202016%2021%20T%20IR.pdf

Thesis An improved process for the production of highly purified recombinant thaumatin tagged-variants

Healey, RD; Lebhar, H; https://orcid.org/0000-0002-9023-2467 et al. · 2017 · UNSW Sydney · DOI

Full title: An improved process for the production of highly purified recombinant thaumatin tagged-variants

Authors: Healey, RD; Lebhar, H ; https://orcid.org/0000-0002-9023-2467; Hornung, S; Thordarson, P ; https://orcid.org/0000-0002-1200-8814; Marquis, CP ; https://orcid.org/0000-0003-1656-7215

Year: 2017

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/unsworks_73890

Thesis Delipidation Treatments for Large-Scale Protein Purification Processing

Gardner, Tara Conti · 2014 · Virginia Tech - VTechWorks · DOI

Full title: Delipidation Treatments for Large-Scale Protein Purification Processing

Authors: Gardner, Tara Conti

Year: 2014

Venue: Virginia Tech - VTechWorks

DOI: http://hdl.handle.net/10919/36512

Thesis Purification of recombinant biopharmaceuticals by preparative electrophoresis

Catzel, Dallia · 2006 · UNSW Sydney · DOI

Full title: Purification of recombinant biopharmaceuticals by preparative electrophoresis

Authors: Catzel, Dallia

Year: 2006

Venue: UNSW Sydney

DOI: http://hdl.handle.net/1959.4/68595

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Metadata only

Paper Safety risk management for low molecular weight process-related impurities in monoclonal antibody therapeutics: Categorization, risk assessment, testing strategy, and process development with leveraging clearance potential.

Luo, Haibin; Li, Yuling; Robbins, David et al. · 2021 · Biotechnology progress · DOI

Full title: Safety risk management for low molecular weight process-related impurities in monoclonal antibody therapeutics: Categorization, risk assessment, testing strategy, and process development with leveraging clearance potential.

Authors: Luo, Haibin; Li, Yuling; Robbins, David; Wang, Sheau-Chiann; Xi, Guoling; Cox, Matthew; Nicholson, Simone M; Wei, Chenghong; Pabst, Timothy M; Wang, William K

Year: 2021

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3119

Paper Design and control of integrated chromatography column sequences.

Andersson, Niklas; Löfgren, Anton; Olofsson, Marianne et al. · 2017 · Biotechnology progress · DOI

Full title: Design and control of integrated chromatography column sequences.

Authors: Andersson, Niklas; Löfgren, Anton; Olofsson, Marianne; Sellberg, Anton; Nilsson, Bernt; Tiainen, Peter

Year: 2017

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2434

Paper Optimization of integrated chromatography sequences for purification of biopharmaceuticals.

Löfgren, Anton; Yamanee-Nolin, Mikael; Tallvod, Simon et al. · 2019 · Biotechnology progress · DOI

Full title: Optimization of integrated chromatography sequences for purification of biopharmaceuticals.

Authors: Löfgren, Anton; Yamanee-Nolin, Mikael; Tallvod, Simon; Fons, Joaquín G; Andersson, Niklas; Nilsson, Bernt

Year: 2019

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2871

Paper Rational design of peptide affinity ligands for the purification of therapeutic enzymes.

Trasatti, John P; Woo, James; Ladiwala, Asif et al. · 2018 · Biotechnology progress · DOI

Full title: Rational design of peptide affinity ligands for the purification of therapeutic enzymes.

Authors: Trasatti, John P; Woo, James; Ladiwala, Asif; Cramer, Steven; Karande, Pankaj

Year: 2018

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2637

Paper Identification of upstream culture conditions and harvest time parameters that affect host cell protein clearance.

Wilson, Louisa J; Lewis, Will; Kucia-Tran, Richard et al. · 2019 · Biotechnology progress · DOI

Full title: Identification of upstream culture conditions and harvest time parameters that affect host cell protein clearance.

Authors: Wilson, Louisa J; Lewis, Will; Kucia-Tran, Richard; Bracewell, Daniel G

Year: 2019

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2805

Paper Development of an activated carbon filtration step and high throughput screening method to remove host cell proteins from a recombinant enzyme process.

Slocum, Ashley; Santora, Steven; Ly, Mellisa et al. · 2021 · Biotechnology progress · DOI

Full title: Development of an activated carbon filtration step and high throughput screening method to remove host cell proteins from a recombinant enzyme process.

Authors: Slocum, Ashley; Santora, Steven; Ly, Mellisa; Zhang, Junyan; Castano, Juan; Becerra-Arteaga, Alejandro

Year: 2021

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3151

Paper Leveraging single-pass tangential flow filtration to enable decoupling of upstream and downstream monoclonal antibody processing.

Brinkmann, Alex; Elouafiq, Sanaa; Pieracci, John et al. · 2018 · Biotechnology progress · DOI

Full title: Leveraging single-pass tangential flow filtration to enable decoupling of upstream and downstream monoclonal antibody processing.

Authors: Brinkmann, Alex; Elouafiq, Sanaa; Pieracci, John; Westoby, Matthew

Year: 2018

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2601

Paper Application of inline variable pathlength technology for rapid determination of dynamic binding capacity in downstream process development of biopharmaceuticals.

Bhangale, Rashmi P; Ye, Rui; Lindsey, Thomas B et al. · 2022 · Biotechnology progress · DOI

Full title: Application of inline variable pathlength technology for rapid determination of dynamic binding capacity in downstream process development of biopharmaceuticals.

Authors: Bhangale, Rashmi P; Ye, Rui; Lindsey, Thomas B; Wolfe, Leslie S

Year: 2022

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3236

Paper Transfer of continuous manufacturing process principles for mAb production in a GMP environment: A step in the transition from batch to continuous.

Botelho Ferreira, Kevin; Benlegrimet, Asma; Diane, Gabriel et al. · 2022 · Biotechnology progress · DOI

Full title: Transfer of continuous manufacturing process principles for mAb production in a GMP environment: A step in the transition from batch to continuous.

Authors: Botelho Ferreira, Kevin; Benlegrimet, Asma; Diane, Gabriel; Pasquier, Victor; Guillot, Raphael; De Poli, Marc; Chappuis, Loïc; Vishwanathan, Nandita; Souquet, Jonathan; Broly, Hervé; Bielser, Jean-Marc

Year: 2022

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3259

Paper Assessment of membrane-based downstream purification processes as a replacement to traditional resin bead for monoclonal antibody purification.

Pasquier, Victor; Botelho Ferreira, Kevin; Lergenmuller, Morgane et al. · 2025 · Biotechnology progress · DOI

Full title: Assessment of membrane-based downstream purification processes as a replacement to traditional resin bead for monoclonal antibody purification.

Authors: Pasquier, Victor; Botelho Ferreira, Kevin; Lergenmuller, Morgane; Tottoli, Alexis; Perilleux, Arnaud; Souquet, Jonathan; Bielser, Jean-Marc

Year: 2025

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3508

Paper Downstream antibody purification using aqueous two-phase extraction.

Mao, Lisong Nathan; Rogers, Jameson K; Westoby, Matthew et al. · 2010 · Biotechnology progress · DOI

Full title: Downstream antibody purification using aqueous two-phase extraction.

Authors: Mao, Lisong Nathan; Rogers, Jameson K; Westoby, Matthew; Conley, Lynn; Pieracci, John

Year: 2010

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.477

Paper Determination of robustness and optimal work conditions for a purification process of a therapeutic recombinant protein using response surface methodology.

Amadeo, Ignacio; Mauro, Laura V; Ortí, Eduardo et al. · 2011 · Biotechnology progress · DOI

Full title: Determination of robustness and optimal work conditions for a purification process of a therapeutic recombinant protein using response surface methodology.

Authors: Amadeo, Ignacio; Mauro, Laura V; Ortí, Eduardo; Forno, Guillermina

Year: 2011

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.588

Paper Demonstrating β-glucan and yeast peptide clearance in biopharmaceutical downstream processes.

Jiang, Canping; Scherfner, Sarah; Dick, Lawrence W et al. · 2011 · Biotechnology progress · DOI

Full title: Demonstrating β-glucan and yeast peptide clearance in biopharmaceutical downstream processes.

Authors: Jiang, Canping; Scherfner, Sarah; Dick, Lawrence W; Mahon, David; Qiu, Difei; Cheng, Kuang-Chuan; Shukla, Abhinav A

Year: 2011

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.568

Paper Optimal synthesis of chromatographic trains for downstream protein processing.

Polykarpou, Eleftheria M; Dalby, Paul A; Papageorgiou, Lazaros G · 2011 · Biotechnology progress · DOI

Full title: Optimal synthesis of chromatographic trains for downstream protein processing.

Authors: Polykarpou, Eleftheria M; Dalby, Paul A; Papageorgiou, Lazaros G

Year: 2011

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.670

Paper Host cell proteins in monoclonal antibody processing: Control, detection, and removal.

Ito, Takao; Lutz, Herb; Tan, Lihan et al. · 2024 · Biotechnology progress · DOI

Full title: Host cell proteins in monoclonal antibody processing: Control, detection, and removal.

Authors: Ito, Takao; Lutz, Herb; Tan, Lihan; Wang, Bin; Tan, Janice; Patel, Masum; Chen, Lance; Tsunakawa, Yuki; Park, Byunghyun; Banerjee, Subhasis

Year: 2024

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3448

Paper Process and economic evaluation for monoclonal antibody purification using a membrane-only process.

Varadaraju, Hemanthram; Schneiderman, Steven; Zhang, Lifeng et al. · 2011 · Biotechnology progress · DOI

Full title: Process and economic evaluation for monoclonal antibody purification using a membrane-only process.

Authors: Varadaraju, Hemanthram; Schneiderman, Steven; Zhang, Lifeng; Fong, Hao; Menkhaus, Todd J

Year: 2011

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.639

Paper Disaggregation of high-molecular weight species during downstream processing to recover functional monomer.

Xu, Xuankuo; Didio, David M; Leister, Kirk J et al. · 2010 · Biotechnology progress · DOI

Full title: Disaggregation of high-molecular weight species during downstream processing to recover functional monomer.

Authors: Xu, Xuankuo; Didio, David M; Leister, Kirk J; Ghose, Sanchayita

Year: 2010

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.373

Paper Host cell protein clearance during protein A chromatography: development of an improved column wash step.

Shukla, Abhinav A; Hinckley, Peter · 2008 · Biotechnology progress · DOI

Full title: Host cell protein clearance during protein A chromatography: development of an improved column wash step.

Authors: Shukla, Abhinav A; Hinckley, Peter

Year: 2008

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.50

Paper A modular and multi-functional purification strategy that enables a common framework for manufacturing scale integrated and continuous biomanufacturing.

Pybus, Leon P; Heise, Charles; Nagy, Tibor et al. · 2024 · Biotechnology progress · DOI

Full title: A modular and multi-functional purification strategy that enables a common framework for manufacturing scale integrated and continuous biomanufacturing.

Authors: Pybus, Leon P; Heise, Charles; Nagy, Tibor; Heeran, Carmen; Dover, Terri; Raven, John; Kori, Junichi; Burton, Graeme; Sakuyama, Hiroshi; Hastings, Benjamin; Lyons, Michelle; Nakai, Shinichi; Haigh, Jonathan

Year: 2024

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.3456

Paper A size-exclusion chromatography fingerprinting workflow for the development of flow-through polishing operations for mAbs derived from continuous precipitation processes.

Gutierrez-Diaz, Mario A; Altern, Scott H; Przybycien, Todd M et al. · 2026 · Biotechnology progress · DOI

Full title: A size-exclusion chromatography fingerprinting workflow for the development of flow-through polishing operations for mAbs derived from continuous precipitation processes.

Authors: Gutierrez-Diaz, Mario A; Altern, Scott H; Przybycien, Todd M; Cramer, Steven M

Year: 2026

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.70104

Paper Evaluation of Escherichia coli proteins that burden nonaffinity-based chromatography as a potential strategy for improved purification performance.

Bartlow, Patrick; Tiwari, Neha; Beitle, Robert R et al. · 2012 · Biotechnology progress · DOI

Full title: Evaluation of Escherichia coli proteins that burden nonaffinity-based chromatography as a potential strategy for improved purification performance.

Authors: Bartlow, Patrick; Tiwari, Neha; Beitle, Robert R; Ataai, Mohammad M

Year: 2012

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.703

Paper Phenolics removal from transgenic Lemna minor extracts expressing mAb and impact on mAb production cost.

Barros, Georgia O F; Woodard, Susan L; Nikolov, Zivko L · 2011 · Biotechnology progress · DOI

Full title: Phenolics removal from transgenic Lemna minor extracts expressing mAb and impact on mAb production cost.

Authors: Barros, Georgia O F; Woodard, Susan L; Nikolov, Zivko L

Year: 2011

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.543

Paper Continuous capture of recombinant antibodies by ZnCl 2 precipitation without polyethylene glycol.

Dutra, Gregory; Komuczki, Daniel; Jungbauer, Alois et al. · 2020 · Engineering in life sciences · DOI

Full title: Continuous capture of recombinant antibodies by ZnCl 2 precipitation without polyethylene glycol.

Authors: Dutra, Gregory; Komuczki, Daniel; Jungbauer, Alois; Satzer, Peter

Year: 2020

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.201900160

Paper Pool-less processing to streamline downstream purification of monoclonal antibodies.

Zhang, Jennifer; Conley, Lynn; Pieracci, John et al. · 2017 · Engineering in life sciences · DOI

Full title: Pool-less processing to streamline downstream purification of monoclonal antibodies.

Authors: Zhang, Jennifer; Conley, Lynn; Pieracci, John; Ghose, Sanchayita

Year: 2017

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.201600104

Paper Closed-loop optimization of chromatography column sizing strategies in biopharmaceutical manufacture.

Allmendinger, Richard; Simaria, Ana S; Turner, Richard et al. · 2014 · Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986) · DOI

Full title: Closed-loop optimization of chromatography column sizing strategies in biopharmaceutical manufacture.

Authors: Allmendinger, Richard; Simaria, Ana S; Turner, Richard; Farid, Suzanne S

Year: 2014

Venue: Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)

DOI: https://doi.org/10.1002/jctb.4267

Paper Two-dimensional difference fluorescence gel electrophoresis to verify the scale-up of a non-affinity-based downstream process for isolation of a therapeutic recombinant antibody.

Grzeskowiak, Julita K; Tscheliessnig, Anne; Wu, Ming Wei et al. · 2010 · Electrophoresis · DOI

Full title: Two-dimensional difference fluorescence gel electrophoresis to verify the scale-up of a non-affinity-based downstream process for isolation of a therapeutic recombinant antibody.

Authors: Grzeskowiak, Julita K; Tscheliessnig, Anne; Wu, Ming Wei; Toh, Poh Choo; Chusainow, Janet; Lee, Yih Yean; Wong, Niki; Jungbauer, Alois

Year: 2010

Venue: Electrophoresis

DOI: https://doi.org/10.1002/elps.200900781

Paper Purification of a peptide tagged protein via an affinity chromatographic process with underivatized silica.

Rauwolf, Stefan; Steegmüller, Tobias; Schwaminger, Sebastian Patrick et al. · 2021 · Engineering in life sciences · DOI

Full title: Purification of a peptide tagged protein via an affinity chromatographic process with underivatized silica.

Authors: Rauwolf, Stefan; Steegmüller, Tobias; Schwaminger, Sebastian Patrick; Berensmeier, Sonja

Year: 2021

Venue: Engineering in life sciences

DOI: https://doi.org/10.1002/elsc.202100019

Paper Continuous annular chromatography.

Wolfgang, Jürgen; Prior, Adalbert · 2002 · Advances in biochemical engineering/biotechnology · DOI

Full title: Continuous annular chromatography.

Authors: Wolfgang, Jürgen; Prior, Adalbert

Year: 2002

Venue: Advances in biochemical engineering/biotechnology

DOI: https://doi.org/10.1007/3-540-45345-8_7

Paper Convective interaction media short monolithic columns: enabling chromatographic supports for the separation and purification of large biomolecules.

Barut, Milos; Podgornik, Ales; Brne, Peter et al. · 2005 · Journal of separation science · DOI

Full title: Convective interaction media short monolithic columns: enabling chromatographic supports for the separation and purification of large biomolecules.

Authors: Barut, Milos; Podgornik, Ales; Brne, Peter; Strancar, Ales

Year: 2005

Venue: Journal of separation science

DOI: https://doi.org/10.1002/jssc.200500246

Paper Continuous Chromatography Purification of Virus-Based Biopharmaceuticals: A Shortcut Design Method.

Silva, Ricardo J S; Mendes, João P; Carrondo, Manuel J T et al. · 2020 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Continuous Chromatography Purification of Virus-Based Biopharmaceuticals: A Shortcut Design Method.

Authors: Silva, Ricardo J S; Mendes, João P; Carrondo, Manuel J T; Marques, Paula M; Peixoto, Cristina

Year: 2020

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-0716-0191-4_21

Paper Scale-Up of Protein Purification: Downstream Processing Issues.

Milne, John Joseph · 2017 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Scale-Up of Protein Purification: Downstream Processing Issues.

Authors: Milne, John Joseph

Year: 2017

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-4939-6412-3_5

Paper Reverse micellar extraction for downstream processing of proteins/enzymes.

Krishna, S Hari; Srinivas, N D; Raghavarao, K S M S et al. · 2002 · Advances in biochemical engineering/biotechnology · DOI

Full title: Reverse micellar extraction for downstream processing of proteins/enzymes.

Authors: Krishna, S Hari; Srinivas, N D; Raghavarao, K S M S; Karanth, N G

Year: 2002

Venue: Advances in biochemical engineering/biotechnology

DOI: https://doi.org/10.1007/3-540-44604-4_5

Paper Scale-Up of Protein Purification: Downstream Processing Issues.

Milne, John Joseph · 2017 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Scale-Up of Protein Purification: Downstream Processing Issues.

Authors: Milne, John Joseph

Year: 2017

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-4939-6412-3_5

Paper Chromatographic techniques in the downstream processing of proteins in biotechnology.

Freitag, Ruth · 2014 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Chromatographic techniques in the downstream processing of proteins in biotechnology.

Authors: Freitag, Ruth

Year: 2014

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-62703-733-4_25

Paper Purification of Recombinant Glycoproteins from Pichia pastoris Culture Supernatants.

Wurm, David Johannes; Spadiut, Oliver · 2019 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Purification of Recombinant Glycoproteins from Pichia pastoris Culture Supernatants.

Authors: Wurm, David Johannes; Spadiut, Oliver

Year: 2019

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-4939-9024-5_17

Paper Interaction of cell culture with downstream purification: a case study.

Berthold, W; Kempken, R · 1994 · Cytotechnology · DOI

Full title: Interaction of cell culture with downstream purification: a case study.

Authors: Berthold, W; Kempken, R

Year: 1994

Venue: Cytotechnology

DOI: https://doi.org/10.1007/BF00762398

Paper PEG-salt aqueous two-phase systems: an attractive and versatile liquid-liquid extraction technology for the downstream processing of proteins and enzymes.

Glyk, Anna; Scheper, Thomas; Beutel, Sascha · 2015 · Applied microbiology and biotechnology · DOI

Full title: PEG-salt aqueous two-phase systems: an attractive and versatile liquid-liquid extraction technology for the downstream processing of proteins and enzymes.

Authors: Glyk, Anna; Scheper, Thomas; Beutel, Sascha

Year: 2015

Venue: Applied microbiology and biotechnology

DOI: https://doi.org/10.1007/s00253-015-6779-7

Paper Recovery of recombinant proteins from plants using aqueous two-phase partitioning systems: an outline.

Gu, Zhengrong · 2014 · Methods in molecular biology (Clifton, N.J.) · DOI

Full title: Recovery of recombinant proteins from plants using aqueous two-phase partitioning systems: an outline.

Authors: Gu, Zhengrong

Year: 2014

Venue: Methods in molecular biology (Clifton, N.J.)

DOI: https://doi.org/10.1007/978-1-62703-977-2_8

Paper Chromatography in the downstream processing of biotechnological products.

Freitag, R; Horváth, C · 1996 · Advances in biochemical engineering/biotechnology · DOI

Full title: Chromatography in the downstream processing of biotechnological products.

Authors: Freitag, R; Horváth, C

Year: 1996

Venue: Advances in biochemical engineering/biotechnology

DOI: https://doi.org/10.1007/BFb0102324

Paper Progress of ligand-modified agarose microspheres for protein isolation and purification.

Qi, Chongdi; Chen, Lei · 2024 · Mikrochimica acta · DOI

Full title: Progress of ligand-modified agarose microspheres for protein isolation and purification.

Authors: Qi, Chongdi; Chen, Lei

Year: 2024

Venue: Mikrochimica acta

DOI: https://doi.org/10.1007/s00604-024-06224-4

Paper Recovery of bovine lysozyme from transgenic sugarcane stalks: extraction, membrane filtration, and purification.

Barros, G O F; Ballen, M A T; Woodard, S L et al. · 2013 · Bioprocess and biosystems engineering · DOI

Full title: Recovery of bovine lysozyme from transgenic sugarcane stalks: extraction, membrane filtration, and purification.

Authors: Barros, G O F; Ballen, M A T; Woodard, S L; Wilken, L R; White, S G; Damaj, M B; Mirkov, T E; Nikolov, Z L

Year: 2013

Venue: Bioprocess and biosystems engineering

DOI: https://doi.org/10.1007/s00449-012-0878-y

Paper Large-scale crystallization as an intermediate processing step in insulin downstream process: explored advantages and identified tool for process intensification.

Hazra, Partha; Buddha, Madhavan; Reddy, Chinnappa et al. · 2023 · Bioprocess and biosystems engineering · DOI

Full title: Large-scale crystallization as an intermediate processing step in insulin downstream process: explored advantages and identified tool for process intensification.

Authors: Hazra, Partha; Buddha, Madhavan; Reddy, Chinnappa; Gupta, Indranil

Year: 2023

Venue: Bioprocess and biosystems engineering

DOI: https://doi.org/10.1007/s00449-023-02931-z

Paper Chromatographic purification of recombinant human erythropoietin.

Adamíková, Jana; Antošová, Monika; Polakovič, Milan · 2019 · Biotechnology letters · DOI

Full title: Chromatographic purification of recombinant human erythropoietin.

Authors: Adamíková, Jana; Antošová, Monika; Polakovič, Milan

Year: 2019

Venue: Biotechnology letters

DOI: https://doi.org/10.1007/s10529-019-02656-8

Paper Self-packed filter plates: a good alternative for pre-packed filter plates for developing purification processes for therapeutic proteins.

Li, Xiaonan; de Roo, Guy; Burgers, Kim et al. · 2012 · Biotechnology journal · DOI

Full title: Self-packed filter plates: a good alternative for pre-packed filter plates for developing purification processes for therapeutic proteins.

Authors: Li, Xiaonan; de Roo, Guy; Burgers, Kim; Ottens, Marcel; Eppink, Michel

Year: 2012

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201200045

Paper A comparison of protein A chromatographic stationary phases: performance characteristics for monoclonal antibody purification.

Liu, Zhuo; Mostafa, Sigma S; Shukla, Abhinav A · 2015 · Biotechnology and applied biochemistry · DOI

Full title: A comparison of protein A chromatographic stationary phases: performance characteristics for monoclonal antibody purification.

Authors: Liu, Zhuo; Mostafa, Sigma S; Shukla, Abhinav A

Year: 2015

Venue: Biotechnology and applied biochemistry

DOI: https://doi.org/10.1002/bab.1243

Paper Scale-down models to optimize a filter train for the downstream purification of recombinant pharmaceutical proteins produced in tobacco leaves.

Buyel, Johannes F; Fischer, Rainer · 2014 · Biotechnology journal · DOI

Full title: Scale-down models to optimize a filter train for the downstream purification of recombinant pharmaceutical proteins produced in tobacco leaves.

Authors: Buyel, Johannes F; Fischer, Rainer

Year: 2014

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201300369

Paper Improved HCP Reduction Using a New, All-Synthetic Depth Filtration Media Within an Antibody Purification Process.

Nguyen, Hoang C; Langland, Amie L; Amara, John P et al. · 2019 · Biotechnology journal · DOI

Full title: Improved HCP Reduction Using a New, All-Synthetic Depth Filtration Media Within an Antibody Purification Process.

Authors: Nguyen, Hoang C; Langland, Amie L; Amara, John P; Dullen, Michael; Kahn, David S; Costanzo, Joseph A

Year: 2019

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201700771

Paper Cellulose-based filter aids increase the capacity of depth filters during the downstream processing of plant-derived biopharmaceutical proteins.

Buyel, Johannes F; Opdensteinen, Patrick; Fischer, Rainer · 2015 · Biotechnology journal · DOI

Full title: Cellulose-based filter aids increase the capacity of depth filters during the downstream processing of plant-derived biopharmaceutical proteins.

Authors: Buyel, Johannes F; Opdensteinen, Patrick; Fischer, Rainer

Year: 2015

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201400611

Paper Quantitative definition and monitoring of the host cell protein proteome using iTRAQ - a study of an industrial mAb producing CHO-S cell line.

Chiverton, Lesley M; Evans, Caroline; Pandhal, Jagroop et al. · 2016 · Biotechnology journal · DOI

Full title: Quantitative definition and monitoring of the host cell protein proteome using iTRAQ - a study of an industrial mAb producing CHO-S cell line.

Authors: Chiverton, Lesley M; Evans, Caroline; Pandhal, Jagroop; Landels, Andrew R; Rees, Byron J; Levison, Peter R; Wright, Phillip C; Smales, C Mark

Year: 2016

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201500550

Paper Crystal Contact Engineering Enables Efficient Capture and Purification of an Oxidoreductase by Technical Crystallization.

Grob, Phillip; Huber, Max; Walla, Brigitte et al. · 2020 · Biotechnology journal · DOI

Full title: Crystal Contact Engineering Enables Efficient Capture and Purification of an Oxidoreductase by Technical Crystallization.

Authors: Grob, Phillip; Huber, Max; Walla, Brigitte; Hermann, Johannes; Janowski, Robert; Niessing, Dierk; Hekmat, Dariusch; Weuster-Botz, Dirk

Year: 2020

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202000010

Paper Generic chromatography-based purification strategies accelerate the development of downstream processes for biopharmaceutical proteins produced in plants.

Buyel, Johannes F; Fischer, Rainer · 2014 · Biotechnology journal · DOI

Full title: Generic chromatography-based purification strategies accelerate the development of downstream processes for biopharmaceutical proteins produced in plants.

Authors: Buyel, Johannes F; Fischer, Rainer

Year: 2014

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201300548

Paper Magnetic Separation on a New Level: Characterization and Performance Prediction of a cGMP Compliant "Rotor-Stator" High-Gradient Magnetic Separator.

Ebeler, Moritz; Pilgram, Florian; Wolz, Kai et al. · 2018 · Biotechnology journal · DOI

Full title: Magnetic Separation on a New Level: Characterization and Performance Prediction of a cGMP Compliant "Rotor-Stator" High-Gradient Magnetic Separator.

Authors: Ebeler, Moritz; Pilgram, Florian; Wolz, Kai; Grim, Gunnar; Franzreb, Matthias

Year: 2018

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201700448

Paper Maximizing productivity of chromatography steps for purification of monoclonal antibodies.

Tugcu, Nihal; Roush, David J; Göklen, Kent E · 2008 · Biotechnology and bioengineering · DOI

Full title: Maximizing productivity of chromatography steps for purification of monoclonal antibodies.

Authors: Tugcu, Nihal; Roush, David J; Göklen, Kent E

Year: 2008

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.21604

Paper A Direct Approach for Process Development Using Single Column Experiments Results in Predictable Streamlined Multi-Column Chromatography Bioprocesses.

Utturkar, Aditya; Gillette, Keith; Sun, Chia-Yun et al. · 2019 · Biotechnology journal · DOI

Full title: A Direct Approach for Process Development Using Single Column Experiments Results in Predictable Streamlined Multi-Column Chromatography Bioprocesses.

Authors: Utturkar, Aditya; Gillette, Keith; Sun, Chia-Yun; Pagkaliwangan, Mark; Quesenberry, Rachel; Schofield, Mark

Year: 2019

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201800243

Paper Membrane technology for purification of therapeutic proteins.

Zydney, Andrew L · 2009 · Biotechnology and bioengineering · DOI

Full title: Membrane technology for purification of therapeutic proteins.

Authors: Zydney, Andrew L

Year: 2009

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.22308

Paper CRDSAT Generated by pCARGHO: A New Efficient Lectin-Based Affinity Tag Method for Safe, Simple, and Low-Cost Protein Purification.

Kriznik, Alexandre; Yéléhé-Okouma, Mélissa; Lec, Jean-Christophe et al. · 2019 · Biotechnology journal · DOI

Full title: CRDSAT Generated by pCARGHO: A New Efficient Lectin-Based Affinity Tag Method for Safe, Simple, and Low-Cost Protein Purification.

Authors: Kriznik, Alexandre; Yéléhé-Okouma, Mélissa; Lec, Jean-Christophe; Groshenry, Guillaume; Le Cordier, Hélène; Charron, Christophe; Quinternet, Marc; Mazon, Hortense; Talfournier, François; Boschi-Muller, Sandrine; Jouzeau, Jean-Yves; Reboul, Pascal

Year: 2019

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.201800214

Paper Magnetic Precipitation: A New Platform for Protein Purification.

Santos, Raquel Dos; Iria, Inês; Manuel, Ana M et al. · 2020 · Biotechnology journal · DOI

Full title: Magnetic Precipitation: A New Platform for Protein Purification.

Authors: Santos, Raquel Dos; Iria, Inês; Manuel, Ana M; Leandro, Ana P; Madeira, Catarina A C; Goncalves, Joao; Carvalho, Ana Luísa; Roque, Ana Cecília A

Year: 2020

Venue: Biotechnology journal

DOI: https://doi.org/10.1002/biot.202000151

Paper Expression of difficult-to-remove host cell protein impurities during extended Chinese hamster ovary cell culture and their impact on continuous bioprocessing.

Valente, Kristin N; Lenhoff, Abraham M; Lee, Kelvin H · 2015 · Biotechnology and bioengineering · DOI

Full title: Expression of difficult-to-remove host cell protein impurities during extended Chinese hamster ovary cell culture and their impact on continuous bioprocessing.

Authors: Valente, Kristin N; Lenhoff, Abraham M; Lee, Kelvin H

Year: 2015

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.25515

Paper Countercurrent tangential chromatography for large-scale protein purification.

Shinkazh, Oleg; Kanani, Dharmesh; Barth, Morgan et al. · 2011 · Biotechnology and bioengineering · DOI

Full title: Countercurrent tangential chromatography for large-scale protein purification.

Authors: Shinkazh, Oleg; Kanani, Dharmesh; Barth, Morgan; Long, Matthew; Hussain, Daniar; Zydney, Andrew L

Year: 2011

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.22960

Paper Micro biochemical engineering to accelerate the design of industrial-scale downstream processes for biopharmaceutical proteins.

Titchener-Hooker, N J; Dunnill, P; Hoare, M · 2008 · Biotechnology and bioengineering · DOI

Full title: Micro biochemical engineering to accelerate the design of industrial-scale downstream processes for biopharmaceutical proteins.

Authors: Titchener-Hooker, N J; Dunnill, P; Hoare, M

Year: 2008

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.21788

Paper The future of protein scaffolds as affinity reagents for purification.

Dias, Ana M G C; Roque, Ana C A · 2017 · Biotechnology and bioengineering · DOI

Full title: The future of protein scaffolds as affinity reagents for purification.

Authors: Dias, Ana M G C; Roque, Ana C A

Year: 2017

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.26090

Paper High-throughput micro-scale cultivations and chromatography modeling: Powerful tools for integrated process development.

Baumann, Pascal; Hahn, Tobias; Hubbuch, Jürgen · 2015 · Biotechnology and bioengineering · DOI

Full title: High-throughput micro-scale cultivations and chromatography modeling: Powerful tools for integrated process development.

Authors: Baumann, Pascal; Hahn, Tobias; Hubbuch, Jürgen

Year: 2015

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.25630

Paper Protected amino acids as novel low-molecular-weight displacers in cation-exchange displacement chromatography.

Kundu, A; Vunnum, S; Jayaraman, G et al. · 1995 · Biotechnology and bioengineering · DOI

Full title: Protected amino acids as novel low-molecular-weight displacers in cation-exchange displacement chromatography.

Authors: Kundu, A; Vunnum, S; Jayaraman, G; Cramer, S M

Year: 1995

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.260480507

Paper Aptamer-based downstream processing of his-tagged proteins utilizing magnetic beads.

Kökpinar, Öznur; Walter, Johanna-Gabriela; Shoham, Yuval et al. · 2011 · Biotechnology and bioengineering · DOI

Full title: Aptamer-based downstream processing of his-tagged proteins utilizing magnetic beads.

Authors: Kökpinar, Öznur; Walter, Johanna-Gabriela; Shoham, Yuval; Stahl, Frank; Scheper, Thomas

Year: 2011

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.23191

Paper Single pass tangential flow filtration to debottleneck downstream processing for therapeutic antibody production.

Dizon-Maspat, Jemelle; Bourret, Justin; D'Agostini, Anna et al. · 2012 · Biotechnology and bioengineering · DOI

Full title: Single pass tangential flow filtration to debottleneck downstream processing for therapeutic antibody production.

Authors: Dizon-Maspat, Jemelle; Bourret, Justin; D'Agostini, Anna; Li, Feng

Year: 2012

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.24377

Paper Continuous downstream processing for high value biological products: A Review.

Zydney, Andrew L · 2016 · Biotechnology and bioengineering · DOI

Full title: Continuous downstream processing for high value biological products: A Review.

Authors: Zydney, Andrew L

Year: 2016

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.25695

Paper Progression of continuous downstream processing of monoclonal antibodies: Current trends and challenges.

Somasundaram, Balaji; Pleitt, Kristina; Shave, Evan et al. · 2018 · Biotechnology and bioengineering · DOI

Full title: Progression of continuous downstream processing of monoclonal antibodies: Current trends and challenges.

Authors: Somasundaram, Balaji; Pleitt, Kristina; Shave, Evan; Baker, Kym; Lua, Linda H L

Year: 2018

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.26812

Paper A combined screening and in silico strategy for the rapid design of integrated downstream processes for process and product-related impurity removal.

Vecchiarello, Nicholas; Timmick, Steven M; Goodwine, Chaz et al. · 2019 · Biotechnology and bioengineering · DOI

Full title: A combined screening and in silico strategy for the rapid design of integrated downstream processes for process and product-related impurity removal.

Authors: Vecchiarello, Nicholas; Timmick, Steven M; Goodwine, Chaz; Crowell, Laura E; Love, Kerry R; Love, J Christopher; Cramer, Steven M

Year: 2019

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.27018

Paper Flow management strategies for a connected purification process.

Goebel, Mathias; Rodrigues, Rui; Pampel, Lars et al. · 2021 · Biotechnology and bioengineering · DOI

Full title: Flow management strategies for a connected purification process.

Authors: Goebel, Mathias; Rodrigues, Rui; Pampel, Lars; Rapp, Johanna; Shultz, Joseph; Cui, Huanchun

Year: 2021

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.27772

Paper An impurity characterization based approach for the rapid development of integrated downstream purification processes.

Timmick, Steven M; Vecchiarello, Nicholas; Goodwine, Chaz et al. · 2018 · Biotechnology and bioengineering · DOI

Full title: An impurity characterization based approach for the rapid development of integrated downstream purification processes.

Authors: Timmick, Steven M; Vecchiarello, Nicholas; Goodwine, Chaz; Crowell, Laura E; Love, Kerry R; Love, J Christopher; Cramer, Steven M

Year: 2018

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.26718

Paper Using artificial neural networks to accelerate flowsheet optimization for downstream process development.

Keulen, Daphne; Hagen, Erik van der; Geldhof, Geoffroy et al. · 2024 · Biotechnology and bioengineering · DOI

Full title: Using artificial neural networks to accelerate flowsheet optimization for downstream process development.

Authors: Keulen, Daphne; Hagen, Erik van der; Geldhof, Geoffroy; Le Bussy, Olivier; Pabst, Martin; Ottens, Marcel

Year: 2024

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28454

Paper Current technologies to endotoxin detection and removal for biopharmaceutical purification.

Schneier, Mason; Razdan, Sidharth; Miller, Allison M et al. · 2020 · Biotechnology and bioengineering · DOI

Full title: Current technologies to endotoxin detection and removal for biopharmaceutical purification.

Authors: Schneier, Mason; Razdan, Sidharth; Miller, Allison M; Briceno, Maria E; Barua, Sutapa

Year: 2020

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.27362

Paper Dual-Stage Cross-Flow Filtration: Integrated Capture and Purification of Virus-Like Particles.

Dietrich, Annabelle; Heim, Luca; Hubbuch, Jürgen · 2025 · Biotechnology and bioengineering · DOI

Full title: Dual-Stage Cross-Flow Filtration: Integrated Capture and Purification of Virus-Like Particles.

Authors: Dietrich, Annabelle; Heim, Luca; Hubbuch, Jürgen

Year: 2025

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28914

Paper A fluidized-bed-riser adsorption system for continuous bioproduct recovery from crude feedstock.

Herlevi, Lisa-Marie; Fernandez-Lahore, Marcelo; Ferreira, Guilherme · 2023 · Biotechnology and bioengineering · DOI

Full title: A fluidized-bed-riser adsorption system for continuous bioproduct recovery from crude feedstock.

Authors: Herlevi, Lisa-Marie; Fernandez-Lahore, Marcelo; Ferreira, Guilherme

Year: 2023

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28458

Paper Tailoring polishing steps for effective removal of polysorbate-degrading host cell proteins in antibody purification.

Maier, Melanie; Schneider, Stefan; Weiss, Linus et al. · 2024 · Biotechnology and bioengineering · DOI

Full title: Tailoring polishing steps for effective removal of polysorbate-degrading host cell proteins in antibody purification.

Authors: Maier, Melanie; Schneider, Stefan; Weiss, Linus; Fischer, Simon; Lakatos, Daniel; Studts, Joey; Franzreb, Matthias

Year: 2024

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28767

Paper Continuous multi-column capture of monoclonal antibodies with convective diffusive membrane adsorbers.

Schmitz, Fabian; Knöchelmann, Elias; Kruse, Thomas et al. · 2024 · Biotechnology and bioengineering · DOI

Full title: Continuous multi-column capture of monoclonal antibodies with convective diffusive membrane adsorbers.

Authors: Schmitz, Fabian; Knöchelmann, Elias; Kruse, Thomas; Minceva, Mirjana; Kampmann, Markus

Year: 2024

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28695

Paper Advances in high-throughput, high-capacity nonwoven membranes for chromatography in downstream processing: A review.

Lavoie, Joseph; Fan, Jinxin; Pourdeyhimi, Behnam et al. · 2024 · Biotechnology and bioengineering · DOI

Full title: Advances in high-throughput, high-capacity nonwoven membranes for chromatography in downstream processing: A review.

Authors: Lavoie, Joseph; Fan, Jinxin; Pourdeyhimi, Behnam; Boi, Cristiana; Carbonell, Ruben G

Year: 2024

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28457

Paper Clear insight into complex multimodal resins and impurities to overcome recombinant protein purification challenges: A review.

Goodarzi, Maryam Moazami; Jalalirad, Reza · 2025 · Biotechnology and bioengineering · DOI

Full title: Clear insight into complex multimodal resins and impurities to overcome recombinant protein purification challenges: A review.

Authors: Goodarzi, Maryam Moazami; Jalalirad, Reza

Year: 2025

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28846

Paper High-throughput methods for miniaturization and automation of monoclonal antibody purification processes.

Treier, Katrin; Hansen, Sigrid; Richter, Carolin et al. · 2012 · Biotechnology progress · DOI

Full title: High-throughput methods for miniaturization and automation of monoclonal antibody purification processes.

Authors: Treier, Katrin; Hansen, Sigrid; Richter, Carolin; Diederich, Patrick; Hubbuch, Jürgen; Lester, Philip

Year: 2012

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.1533

Paper Mixed reverse micelles facilitated downstream processing of lipase involving water-oil-water liquid emulsion membrane.

Bhowal, Saibal; Priyanka, B S; Rastogi, Navin K · 2014 · Biotechnology progress · DOI

Full title: Mixed reverse micelles facilitated downstream processing of lipase involving water-oil-water liquid emulsion membrane.

Authors: Bhowal, Saibal; Priyanka, B S; Rastogi, Navin K

Year: 2014

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.1941

Paper Downstream Process Intensification for AAV Purification by Affinity Chromatography Using Single Pass Tangential Flow Filtration.

Chaubal, Akshay S; Horax, Ronny; Yehl, Christopher J et al. · 2026 · Biotechnology and bioengineering · DOI

Full title: Downstream Process Intensification for AAV Purification by Affinity Chromatography Using Single Pass Tangential Flow Filtration.

Authors: Chaubal, Akshay S; Horax, Ronny; Yehl, Christopher J; Wickramasinghe, S Ranil; Qian, Xianghong; Wang, Lu; Zydney, Andrew L

Year: 2026

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.70090

Paper Experimental characterization and prediction of Escherichia coli host cell proteome retention during preparative chromatography.

Disela, Roxana; Neijenhuis, Tim; Le Bussy, Olivier et al. · 2024 · Biotechnology and bioengineering · DOI

Full title: Experimental characterization and prediction of Escherichia coli host cell proteome retention during preparative chromatography.

Authors: Disela, Roxana; Neijenhuis, Tim; Le Bussy, Olivier; Geldhof, Geoffroy; Klijn, Marieke; Pabst, Martin; Ottens, Marcel

Year: 2024

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28840

Paper Reverse micelles-mediated transport of lipase in liquid emulsion membrane for downstream processing.

Bhavya, S G; Priyanka, B S; Rastogi, Navin K · 2012 · Biotechnology progress · DOI

Full title: Reverse micelles-mediated transport of lipase in liquid emulsion membrane for downstream processing.

Authors: Bhavya, S G; Priyanka, B S; Rastogi, Navin K

Year: 2012

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.1637

Paper Multipronged approach to managing beta-glucan contaminants in the downstream process: control of raw materials and filtration with charge-modified nylon 6,6 membrane filters.

Gefroh, Eva; Hewig, Art; Vedantham, Ganesh et al. · 2013 · Biotechnology progress · DOI

Full title: Multipronged approach to managing beta-glucan contaminants in the downstream process: control of raw materials and filtration with charge-modified nylon 6,6 membrane filters.

Authors: Gefroh, Eva; Hewig, Art; Vedantham, Ganesh; McClure, Megan; Krivosheyeva, Alla; Lajmi, Ajay; Lu, Yuefeng

Year: 2013

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.1718

Paper Optimization of biopharmaceutical downstream processes supported by mechanistic models and artificial neural networks.

Pirrung, Silvia M; van der Wielen, Luuk A M; van Beckhoven, Ruud F W C et al. · 2017 · Biotechnology progress · DOI

Full title: Optimization of biopharmaceutical downstream processes supported by mechanistic models and artificial neural networks.

Authors: Pirrung, Silvia M; van der Wielen, Luuk A M; van Beckhoven, Ruud F W C; van de Sandt, Emile J A X; Eppink, Michel H M; Ottens, Marcel

Year: 2017

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2435

Paper State-of-the-art in downstream processing of monoclonal antibodies: process trends in design and validation.

Marichal-Gallardo, P A; Alvarez, M M · 2012 · Biotechnology progress · DOI

Full title: State-of-the-art in downstream processing of monoclonal antibodies: process trends in design and validation.

Authors: Marichal-Gallardo, P A; Alvarez, M M

Year: 2012

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.1567

Paper Implementation of an experimental and computational tool set to study protein-mAb interactions.

Ranjan, Swarnim; Chung, Wai Keen; Zhu, Min et al. · 2019 · Biotechnology progress · DOI

Full title: Implementation of an experimental and computational tool set to study protein-mAb interactions.

Authors: Ranjan, Swarnim; Chung, Wai Keen; Zhu, Min; Robbins, David; Cramer, Steven M

Year: 2019

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2825

Paper The affinity technology in downstream processing.

Labrou, N; Clonis, Y D · 1994 · Journal of biotechnology · DOI

Full title: The affinity technology in downstream processing.

Authors: Labrou, N; Clonis, Y D

Year: 1994

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/0168-1656(94)90047-7

Paper Affinity chromatography supports: a look at performance requirements.

Narayanan, S R; Crane, L J · 1990 · Trends in biotechnology · DOI

Full title: Affinity chromatography supports: a look at performance requirements.

Authors: Narayanan, S R; Crane, L J

Year: 1990

Venue: Trends in biotechnology

DOI: https://doi.org/10.1016/0167-7799(90)90124-g

Paper Improvement of downstream processing of recombinant proteins by means of genetic engineering methods.

Flaschel, E; Friehs, K · 1993 · Biotechnology advances · DOI

Full title: Improvement of downstream processing of recombinant proteins by means of genetic engineering methods.

Authors: Flaschel, E; Friehs, K

Year: 1993

Venue: Biotechnology advances

DOI: https://doi.org/10.1016/0734-9750(93)90409-g

Paper Emerging biomaterials for downstream manufacturing of therapeutic proteins.

Li, Yi; Stern, David; Lock, Lye Lin et al. · 2019 · Acta biomaterialia · DOI

Full title: Emerging biomaterials for downstream manufacturing of therapeutic proteins.

Authors: Li, Yi; Stern, David; Lock, Lye Lin; Mills, Jason; Ou, Shih-Hao; Morrow, Marina; Xu, Xuankuo; Ghose, Sanchayita; Li, Zheng Jian; Cui, Honggang

Year: 2019

Venue: Acta biomaterialia

DOI: https://doi.org/10.1016/j.actbio.2019.03.015

Paper Glycan profile of CHO derived IgM purified by highly efficient single step affinity chromatography.

Hennicke, Julia; Lastin, Anna Maria; Reinhart, David et al. · 2017 · Analytical biochemistry · DOI

Full title: Glycan profile of CHO derived IgM purified by highly efficient single step affinity chromatography.

Authors: Hennicke, Julia; Lastin, Anna Maria; Reinhart, David; Grünwald-Gruber, Clemens; Altmann, Friedrich; Kunert, Renate

Year: 2017

Venue: Analytical biochemistry

DOI: https://doi.org/10.1016/j.ab.2017.10.020

Paper Renaissance of protein crystallization and precipitation in biopharmaceuticals purification.

Dos Santos, Raquel; Carvalho, Ana Luísa; Roque, A Cecília A · 2017 · Biotechnology advances · DOI

Full title: Renaissance of protein crystallization and precipitation in biopharmaceuticals purification.

Authors: Dos Santos, Raquel; Carvalho, Ana Luísa; Roque, A Cecília A

Year: 2017

Venue: Biotechnology advances

DOI: https://doi.org/10.1016/j.biotechadv.2016.11.005

Paper Extraction and downstream processing of plant-derived recombinant proteins.

Buyel, J F; Twyman, R M; Fischer, R · 2015 · Biotechnology advances · DOI

Full title: Extraction and downstream processing of plant-derived recombinant proteins.

Authors: Buyel, J F; Twyman, R M; Fischer, R

Year: 2015

Venue: Biotechnology advances

DOI: https://doi.org/10.1016/j.biotechadv.2015.04.010

Paper Green bioprocessing of protein from Chlorella vulgaris microalgae towards circular bioeconomy.

Azmi, Abdul Azim Bin; Chew, Kit Wayne; Chia, Wen Yi et al. · 2021 · Bioresource technology · DOI

Full title: Green bioprocessing of protein from Chlorella vulgaris microalgae towards circular bioeconomy.

Authors: Azmi, Abdul Azim Bin; Chew, Kit Wayne; Chia, Wen Yi; Mubashir, Muhammad; Sankaran, Revathy; Lam, Man Kee; Lim, Jun Wei; Ho, Yeek-Chia; Show, Pau Loke

Year: 2021

Venue: Bioresource technology

DOI: https://doi.org/10.1016/j.biortech.2021.125197

Paper Analytical characterization of complex, biotechnological feedstocks by pH gradient ion exchange chromatography for purification process development.

Kröner, Frieder; Hanke, Alexander T; Nfor, Beckley K et al. · 2013 · Journal of chromatography. A · DOI

Full title: Analytical characterization of complex, biotechnological feedstocks by pH gradient ion exchange chromatography for purification process development.

Authors: Kröner, Frieder; Hanke, Alexander T; Nfor, Beckley K; Pinkse, Martijn W H; Verhaert, Peter D E M; Ottens, Marcel; Hubbuch, Jürgen

Year: 2013

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2013.08.034

Paper Efficient removal of antibody aggregates using TOYOPEARL MX-Trp-650M mixed-mode resin under salt or pH gradient elution.

Zhang, Jinyi; Zhang, Penglong; Li, Yifeng · 2025 · Journal of biological methods · DOI

Full title: Efficient removal of antibody aggregates using TOYOPEARL MX-Trp-650M mixed-mode resin under salt or pH gradient elution.

Authors: Zhang, Jinyi; Zhang, Penglong; Li, Yifeng

Year: 2025

Venue: Journal of biological methods

DOI: https://doi.org/10.14440/jbm.0029

Paper Global screening of protein chromatographic behavior on ion exchangers from a complex cell proteome. Towards in silico downstream processing of bioproducts.

Cabrera, Rosa; Fernandez-Lahore, Marcelo · 2007 · Journal of chromatography. A · DOI

Full title: Global screening of protein chromatographic behavior on ion exchangers from a complex cell proteome. Towards in silico downstream processing of bioproducts.

Authors: Cabrera, Rosa; Fernandez-Lahore, Marcelo

Year: 2007

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2007.02.036

Paper Two-dimensional fluorescence difference gel electrophoresis for comparison of affinity and non-affinity based downstream processing of recombinant monoclonal antibody.

Grzeskowiak, Julita K; Tscheliessnig, Anne; Toh, Poh Choo et al. · 2009 · Journal of chromatography. A · DOI

Full title: Two-dimensional fluorescence difference gel electrophoresis for comparison of affinity and non-affinity based downstream processing of recombinant monoclonal antibody.

Authors: Grzeskowiak, Julita K; Tscheliessnig, Anne; Toh, Poh Choo; Chusainow, Janet; Lee, Yih Yean; Wong, Niki; Jungbauer, Alois

Year: 2009

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2009.04.014

Paper The distinctive separation attributes of mixed-mode resins and their application in monoclonal antibody downstream purification process.

Chen, Jie; Tetrault, Jen; Zhang, Yanyu et al. · 2010 · Journal of chromatography. A · DOI

Full title: The distinctive separation attributes of mixed-mode resins and their application in monoclonal antibody downstream purification process.

Authors: Chen, Jie; Tetrault, Jen; Zhang, Yanyu; Wasserman, Andy; Conley, Greg; Dileo, Mike; Haimes, Elliot; Nixon, Andrew E; Ley, Arthur

Year: 2010

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2009.09.047

Paper Automated high-throughput protein purification using an ÄKTApurifier and a CETAC autosampler.

Yoo, Daniel; Provchy, Justin; Park, Cynthia et al. · 2014 · Journal of chromatography. A · DOI

Full title: Automated high-throughput protein purification using an ÄKTApurifier and a CETAC autosampler.

Authors: Yoo, Daniel; Provchy, Justin; Park, Cynthia; Schulz, Craig; Walker, Kenneth

Year: 2014

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2014.04.014

Paper Computational fluid dynamic simulation of axial and radial flow membrane chromatography: mechanisms of non-ideality and validation of the zonal rate model.

Ghosh, Pranay; Vahedipour, Kaveh; Lin, Min et al. · 2013 · Journal of chromatography. A · DOI

Full title: Computational fluid dynamic simulation of axial and radial flow membrane chromatography: mechanisms of non-ideality and validation of the zonal rate model.

Authors: Ghosh, Pranay; Vahedipour, Kaveh; Lin, Min; Vogel, Jens H; Haynes, Charles; von Lieres, Eric

Year: 2013

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2013.07.004

Paper Determination of adsorption isotherm parameters for minor whey proteins by gradient elution preparative liquid chromatography.

Faraji, Naeimeh; Zhang, Yan; Ray, Ajay K · 2015 · Journal of chromatography. A · DOI

Full title: Determination of adsorption isotherm parameters for minor whey proteins by gradient elution preparative liquid chromatography.

Authors: Faraji, Naeimeh; Zhang, Yan; Ray, Ajay K

Year: 2015

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2015.08.004

Paper Target protein separation and preparation by free-flow electrophoresis coupled with charge-to-mass ratio analysis.

Shen, Qiao-Yi; Guo, Chen-Gang; Yan, Jian et al. · 2015 · Journal of chromatography. A · DOI

Full title: Target protein separation and preparation by free-flow electrophoresis coupled with charge-to-mass ratio analysis.

Authors: Shen, Qiao-Yi; Guo, Chen-Gang; Yan, Jian; Zhang, Qiang; Xie, Hai-Yang; Jahan, Sharmin; Fan, Liu-Yin; Xiao, Hua; Cao, Cheng-Xi

Year: 2015

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2015.04.012

Paper Identification and tracking of problematic host cell proteins removed by a synthetic, highly functionalized nonwoven media in downstream bioprocessing of monoclonal antibodies.

Gilgunn, S; El-Sabbahy, H; Albrecht, S et al. · 2019 · Journal of chromatography. A · DOI

Full title: Identification and tracking of problematic host cell proteins removed by a synthetic, highly functionalized nonwoven media in downstream bioprocessing of monoclonal antibodies.

Authors: Gilgunn, S; El-Sabbahy, H; Albrecht, S; Gaikwad, M; Corrigan, K; Deakin, L; Jellum, G; Bones, J

Year: 2019

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2019.02.056

Paper Non-protein A purification platform for continuous processing of monoclonal antibody therapeutics.

Kateja, Nikhil; Kumar, Devashish; Sethi, Suruchi et al. · 2018 · Journal of chromatography. A · DOI

Full title: Non-protein A purification platform for continuous processing of monoclonal antibody therapeutics.

Authors: Kateja, Nikhil; Kumar, Devashish; Sethi, Suruchi; Rathore, Anurag S

Year: 2018

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2018.10.031

Paper Definition and dynamic control of a continuous chromatography process independent of cell culture titer and impurities.

Chmielowski, Rebecca A; Mathiasson, Linda; Blom, Hans et al. · 2017 · Journal of chromatography. A · DOI

Full title: Definition and dynamic control of a continuous chromatography process independent of cell culture titer and impurities.

Authors: Chmielowski, Rebecca A; Mathiasson, Linda; Blom, Hans; Go, Daniel; Ehring, Hanno; Khan, Heera; Li, Hong; Cutler, Collette; Lacki, Karol; Tugcu, Nihal; Roush, David

Year: 2017

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2017.10.030

Paper Optimization study on periodic counter-current chromatography integrated in a monoclonal antibody downstream process.

Gomis-Fons, Joaquín; Andersson, Niklas; Nilsson, Bernt · 2020 · Journal of chromatography. A · DOI

Full title: Optimization study on periodic counter-current chromatography integrated in a monoclonal antibody downstream process.

Authors: Gomis-Fons, Joaquín; Andersson, Niklas; Nilsson, Bernt

Year: 2020

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2020.461055

Paper Recent advances to accelerate purification process development: A review with a focus on vaccines.

Keulen, Daphne; Geldhof, Geoffroy; Bussy, Olivier Le et al. · 2022 · Journal of chromatography. A · DOI

Full title: Recent advances to accelerate purification process development: A review with a focus on vaccines.

Authors: Keulen, Daphne; Geldhof, Geoffroy; Bussy, Olivier Le; Pabst, Martin; Ottens, Marcel

Year: 2022

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2022.463195

Paper Rational design of affinity ligands for bioseparation.

Matos, Manuel J B; Pina, Ana S; Roque, A C A · 2020 · Journal of chromatography. A · DOI

Full title: Rational design of affinity ligands for bioseparation.

Authors: Matos, Manuel J B; Pina, Ana S; Roque, A C A

Year: 2020

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2020.460871

Paper Design of an integrated continuous downstream process for acid-sensitive monoclonal antibodies based on a calcium-dependent Protein A ligand.

Scheffel, Julia; Isaksson, Madelène; Gomis-Fons, Joaquín et al. · 2022 · Journal of chromatography. A · DOI

Full title: Design of an integrated continuous downstream process for acid-sensitive monoclonal antibodies based on a calcium-dependent Protein A ligand.

Authors: Scheffel, Julia; Isaksson, Madelène; Gomis-Fons, Joaquín; Schwarz, Hubert; Andersson, Niklas; Norén, Björn; Solbrand, Anita; Chotteau, Veronique; Hober, Sophia; Nilsson, Bernt

Year: 2022

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2022.462806

Paper Comparative evaluation of integrated purification pathways for bacterial modular polyomavirus major capsid protein VP1 to produce virus-like particles using high throughput process technologies.

Gerstweiler, Lukas; Billakanti, Jagan; Bi, Jingxiu et al. · 2021 · Journal of chromatography. A · DOI

Full title: Comparative evaluation of integrated purification pathways for bacterial modular polyomavirus major capsid protein VP1 to produce virus-like particles using high throughput process technologies.

Authors: Gerstweiler, Lukas; Billakanti, Jagan; Bi, Jingxiu; Middelberg, Anton

Year: 2021

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2021.461924

Paper Application of mechanistic modelling in membrane and fiber chromatography for purification of biotherapeutics - A review.

Qu, Yiran; Baker, Irene; Black, Jamie et al. · 2024 · Journal of chromatography. A · DOI

Full title: Application of mechanistic modelling in membrane and fiber chromatography for purification of biotherapeutics - A review.

Authors: Qu, Yiran; Baker, Irene; Black, Jamie; Fabri, Louis; Gras, Sally L; Lenhoff, Abraham M; Kentish, Sandra E

Year: 2024

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2023.464588

Paper An automated buffer management system for small-scale continuous downstream bioprocessing.

Isaksson, Madelène; Gomis-Fons, Joaquín; Andersson, Niklas et al. · 2023 · Journal of chromatography. A · DOI

Full title: An automated buffer management system for small-scale continuous downstream bioprocessing.

Authors: Isaksson, Madelène; Gomis-Fons, Joaquín; Andersson, Niklas; Nilsson, Bernt

Year: 2023

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2023.463942

Paper Microfluidic platform for rapid screening of bacterial cell lysis.

Fradique, Ricardo; Azevedo, Ana M; Chu, Virginia et al. · 2020 · Journal of chromatography. A · DOI

Full title: Microfluidic platform for rapid screening of bacterial cell lysis.

Authors: Fradique, Ricardo; Azevedo, Ana M; Chu, Virginia; Conde, João P; Aires-Barros, M Raquel

Year: 2020

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2019.460539

Paper The impact of endotoxin masking on the removal of endotoxin during manufacturing of a biopharmaceutical drug product.

Wespel, Martina; Geiss, Melanie; Nägele, Matthias et al. · 2022 · Journal of chromatography. A · DOI

Full title: The impact of endotoxin masking on the removal of endotoxin during manufacturing of a biopharmaceutical drug product.

Authors: Wespel, Martina; Geiss, Melanie; Nägele, Matthias; Combé, Stephanie; Reich, Johannes; Studts, Joey; Stolzenberger, Jessica

Year: 2022

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2022.462995

Paper Structural study of a light chain mispaired bispecific predicts mechanism of downstream separation.

Cha, Minjeong; Xu, Ankai; Williams, Ambrose J · 2024 · Journal of chromatography. A · DOI

Full title: Structural study of a light chain mispaired bispecific predicts mechanism of downstream separation.

Authors: Cha, Minjeong; Xu, Ankai; Williams, Ambrose J

Year: 2024

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2024.465117

Paper Autonomous operation and quality monitoring of a continuous antibody downstream process.

Isaksson, Madelène; Espinoza, Daniel; Lorek, Julius Klemens et al. · 2025 · Journal of chromatography. A · DOI

Full title: Autonomous operation and quality monitoring of a continuous antibody downstream process.

Authors: Isaksson, Madelène; Espinoza, Daniel; Lorek, Julius Klemens; Sondell, Maja; Nilsson, Bernt; Andersson, Niklas

Year: 2025

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2025.466157

Paper Development of continuous processing platform utilizing aqueous two-phase extraction for purification of monoclonal antibodies.

Anupa, Anupa; Metya, Subhankar; Mihooliya, Kanti N et al. · 2024 · Journal of chromatography. A · DOI

Full title: Development of continuous processing platform utilizing aqueous two-phase extraction for purification of monoclonal antibodies.

Authors: Anupa, Anupa; Metya, Subhankar; Mihooliya, Kanti N; Rathore, Anurag S

Year: 2024

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2023.464605

Paper Integration of QSAR models with high throughput screening to accelerate the development of polishing chromatography unit operations.

Hartmann, Michael; Rauscher, Michael; Robinson, Julie et al. · 2025 · Journal of chromatography. A · DOI

Full title: Integration of QSAR models with high throughput screening to accelerate the development of polishing chromatography unit operations.

Authors: Hartmann, Michael; Rauscher, Michael; Robinson, Julie; Welsh, John; Roush, David

Year: 2025

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2025.465818

Paper Improving the sustainability of biopharmaceutical downstream processing through buffer recycling.

Isaksson, Madelène; Andersson, Niklas; Nilsson, Bernt · 2025 · Journal of chromatography. A · DOI

Full title: Improving the sustainability of biopharmaceutical downstream processing through buffer recycling.

Authors: Isaksson, Madelène; Andersson, Niklas; Nilsson, Bernt

Year: 2025

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2024.465545

Paper Ionic liquids for biomacromolecule purification: from molecular interactions to practical applications.

Yan, Zi-Ang; Su, Zhiguo; Zhao, Jingyang et al. · 2026 · Journal of chromatography. A · DOI

Full title: Ionic liquids for biomacromolecule purification: from molecular interactions to practical applications.

Authors: Yan, Zi-Ang; Su, Zhiguo; Zhao, Jingyang; Zhang, Songping

Year: 2026

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2026.466797

Paper Aqueous biphasic systems based on deep eutectic solvents for extraction of biopharmaceuticals in downstream processing.

Cunha, Diana R; Hsieh, Shu-An; Quinaz, M Beatriz et al. · 2026 · Journal of chromatography. A · DOI

Full title: Aqueous biphasic systems based on deep eutectic solvents for extraction of biopharmaceuticals in downstream processing.

Authors: Cunha, Diana R; Hsieh, Shu-An; Quinaz, M Beatriz; Segundo, Marcela A; Anderson, Jared L

Year: 2026

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2025.466514

Paper Improved clearance of host cell protein impurities at the polishing purification step using multimodal chromatography.

Hutchinson, Jack; Lu, Yali; Grew, Lara et al. · 2024 · Journal of chromatography. A · DOI

Full title: Improved clearance of host cell protein impurities at the polishing purification step using multimodal chromatography.

Authors: Hutchinson, Jack; Lu, Yali; Grew, Lara; Cui, Tingting

Year: 2024

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2024.465229

Paper Implementation of multimodal anion exchange chromatography to address product quality challenges and downstream platform limitations: A case study.

Robinson, Julie; Vats, Mayank; Hartmann, Michael · 2025 · Journal of chromatography. A · DOI

Full title: Implementation of multimodal anion exchange chromatography to address product quality challenges and downstream platform limitations: A case study.

Authors: Robinson, Julie; Vats, Mayank; Hartmann, Michael

Year: 2025

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2025.465784

Paper Solubilization of proteins in aqueous two-phase extraction through combinations of phase-formers and displacement agents.

Kress, Christian; Sadowski, Gabriele; Brandenbusch, Christoph · 2017 · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · DOI

Full title: Solubilization of proteins in aqueous two-phase extraction through combinations of phase-formers and displacement agents.

Authors: Kress, Christian; Sadowski, Gabriele; Brandenbusch, Christoph

Year: 2017

Venue: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

DOI: https://doi.org/10.1016/j.ejpb.2016.11.016

Paper DOE-based process optimization for development of efficient methods for purification of recombinant hepatitis B surface antigen from Pichia pastoris feedstock using Capto adhere resin.

Moazami Goodarzi, Maryam; Jalalirad, Reza; Doroud, Delaram et al. · 2024 · Heliyon · DOI

Full title: DOE-based process optimization for development of efficient methods for purification of recombinant hepatitis B surface antigen from Pichia pastoris feedstock using Capto adhere resin.

Authors: Moazami Goodarzi, Maryam; Jalalirad, Reza; Doroud, Delaram; Hozouri, Hamidreza; Aghasadeghi, Mohammad Reza

Year: 2024

Venue: Heliyon

DOI: https://doi.org/10.1016/j.heliyon.2024.e35124

Paper Downstream processing of monoclonal antibodies--application of platform approaches.

Shukla, Abhinav A; Hubbard, Brian; Tressel, Tim et al. · 2007 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · DOI

Full title: Downstream processing of monoclonal antibodies--application of platform approaches.

Authors: Shukla, Abhinav A; Hubbard, Brian; Tressel, Tim; Guhan, Sam; Low, Duncan

Year: 2007

Venue: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

DOI: https://doi.org/10.1016/j.jchromb.2006.09.026

Paper Fractionation of proteins with two-sided electro-ultrafiltration.

Käppler, Tobias; Posten, Clemens · 2007 · Journal of biotechnology · DOI

Full title: Fractionation of proteins with two-sided electro-ultrafiltration.

Authors: Käppler, Tobias; Posten, Clemens

Year: 2007

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2007.01.002

Paper Large-scale monoclonal antibody purification by continuous chromatography, from process design to scale-up.

Girard, Valérie; Hilbold, Nicolas-Julian; Ng, Candy K S et al. · 2015 · Journal of biotechnology · DOI

Full title: Large-scale monoclonal antibody purification by continuous chromatography, from process design to scale-up.

Authors: Girard, Valérie; Hilbold, Nicolas-Julian; Ng, Candy K S; Pegon, Laurence; Chahim, Wael; Rousset, Fabien; Monchois, Vincent

Year: 2015

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2015.04.026

Paper Protein partition coefficients can be estimated efficiently by hybrid shortcut calculations.

Kress, Christian; Sadowski, Gabriele; Brandenbusch, Christoph · 2016 · Journal of biotechnology · DOI

Full title: Protein partition coefficients can be estimated efficiently by hybrid shortcut calculations.

Authors: Kress, Christian; Sadowski, Gabriele; Brandenbusch, Christoph

Year: 2016

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2016.06.032

Paper Integration of a complete downstream process for the automated lab-scale production of a recombinant protein.

Gomis-Fons, Joaquín; Löfgren, Anton; Andersson, Niklas et al. · 2019 · Journal of biotechnology · DOI

Full title: Integration of a complete downstream process for the automated lab-scale production of a recombinant protein.

Authors: Gomis-Fons, Joaquín; Löfgren, Anton; Andersson, Niklas; Nilsson, Bernt; Berghard, Lotta; Wood, Susanne

Year: 2019

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2019.05.013

Paper Comparison of Tobacco Host Cell Protein Removal Methods by Blanching Intact Plants or by Heat Treatment of Extracts.

Buyel, Johannes F; Hubbuch, Jürgen; Fischer, Rainer · 2016 · Journal of visualized experiments : JoVE · DOI

Full title: Comparison of Tobacco Host Cell Protein Removal Methods by Blanching Intact Plants or by Heat Treatment of Extracts.

Authors: Buyel, Johannes F; Hubbuch, Jürgen; Fischer, Rainer

Year: 2016

Venue: Journal of visualized experiments : JoVE

DOI: https://doi.org/10.3791/54343

Paper Advantages of MabSelect VH3, a novel VH3-specific Protein A resin, over its two conventional counterparts in purifying a VHH-based trispecific antibody.

Fang, Dongdong; Qi, Wenjing; Li, Yifeng · 2025 · Journal of biological methods · DOI

Full title: Advantages of MabSelect VH3, a novel VH3-specific Protein A resin, over its two conventional counterparts in purifying a VHH-based trispecific antibody.

Authors: Fang, Dongdong; Qi, Wenjing; Li, Yifeng

Year: 2025

Venue: Journal of biological methods

DOI: https://doi.org/10.14440/jbm.0138

Paper The applications of reactive dyes in enzyme and protein downstream processing.

Clonis, Y D · 1988 · Critical reviews in biotechnology · DOI

Full title: The applications of reactive dyes in enzyme and protein downstream processing.

Authors: Clonis, Y D

Year: 1988

Venue: Critical reviews in biotechnology

DOI: https://doi.org/10.3109/07388558809150534

Paper Downstream processing of biopharmaceutical proteins produced in plants: the pros and cons of flocculants.

Buyel, Johannes Felix; Fischer, Rainer · 2014 · Bioengineered · DOI

Full title: Downstream processing of biopharmaceutical proteins produced in plants: the pros and cons of flocculants.

Authors: Buyel, Johannes Felix; Fischer, Rainer

Year: 2014

Venue: Bioengineered

DOI: https://doi.org/10.4161/bioe.28061

Paper Optimization and revision of the production process of the Necator americanus glutathione S-transferase 1 (Na-GST-1), the lead hookworm vaccine recombinant protein candidate.

Curti, Elena; Seid, Christopher A; Hudspeth, Elissa et al. · 2014 · Human vaccines & immunotherapeutics · DOI

Full title: Optimization and revision of the production process of the Necator americanus glutathione S-transferase 1 (Na-GST-1), the lead hookworm vaccine recombinant protein candidate.

Authors: Curti, Elena; Seid, Christopher A; Hudspeth, Elissa; Center, Lori; Rezende, Wanderson; Pollet, Jeroen; Kwityn, Cliff; Hammond, Molly; Matsunami, Rise K; Engler, David A; Hotez, Peter J; Elena Bottazzi, Maria

Year: 2014

Venue: Human vaccines & immunotherapeutics

DOI: https://doi.org/10.4161/hv.28872

Paper Expanded bed chromatography and radial flow column chromatography: the approaches for adsorption chromatography of biomolecules on industrial scale.

Ambedkar, S S; Deshpande, B S · 1994 · Hindustan antibiotics bulletin

Full title: Expanded bed chromatography and radial flow column chromatography: the approaches for adsorption chromatography of biomolecules on industrial scale.

Authors: Ambedkar, S S; Deshpande, B S

Year: 1994

Venue: Hindustan antibiotics bulletin

Paper Direct coupling of expanded bed adsorption with a downstream purification step.

Beck, J T; Williamson, B; Tipton, B · 1999 · Bioseparation

Full title: Direct coupling of expanded bed adsorption with a downstream purification step.

Authors: Beck, J T; Williamson, B; Tipton, B

Year: 1999

Venue: Bioseparation

Paper The effect of cell disruption techniques and chaotropic agents on the downstream purification process of mecasermin produced as inclusion body in E. coli.

Haddad, Leila; Babaeipour, Valiollah; Mofid, Mohammad Reza · 2015 · Research in pharmaceutical sciences

Full title: The effect of cell disruption techniques and chaotropic agents on the downstream purification process of mecasermin produced as inclusion body in E. coli.

Authors: Haddad, Leila; Babaeipour, Valiollah; Mofid, Mohammad Reza

Year: 2015

Venue: Research in pharmaceutical sciences

Paper Separation processes in biotechnology. Precipitation.

Glatz, C E · 1990 · Bioprocess technology

Full title: Separation processes in biotechnology. Precipitation.

Authors: Glatz, C E

Year: 1990

Venue: Bioprocess technology

Paper The Amicon Pro system--a centrifugal device capable of performing all steps in the protein purification workflow.

Cappione, Amedeo; Mabuchi, Masaharu; Suhrawardy, Saosan et al. · 2013 · Postepy biochemii

Full title: The Amicon Pro system--a centrifugal device capable of performing all steps in the protein purification workflow.

Authors: Cappione, Amedeo; Mabuchi, Masaharu; Suhrawardy, Saosan; Briggs, David; Nadler, Timothy

Year: 2013

Venue: Postepy biochemii

Paper Feasibility of using continuous chromatography in downstream processing: Comparison of costs and product quality for a hybrid process vs. a conventional batch process.

Ötes, Ozan; Flato, Hendrik; Winderl, Johannes et al. · 2017 · Journal of biotechnology · DOI

Full title: Feasibility of using continuous chromatography in downstream processing: Comparison of costs and product quality for a hybrid process vs. a conventional batch process.

Authors: Ötes, Ozan; Flato, Hendrik; Winderl, Johannes; Hubbuch, Jürgen; Capito, Florian

Year: 2017

Venue: Journal of biotechnology

DOI: https://doi.org/10.1016/j.jbiotec.2017.07.001

Paper Automated optimization of resin selection, wash parameters, and elution parameters for protein A-based purifications.

Anderson, Gracie K; Hicks, Mark; Hamlyn, Penny et al. · 2026 · New biotechnology · DOI

Full title: Automated optimization of resin selection, wash parameters, and elution parameters for protein A-based purifications.

Authors: Anderson, Gracie K; Hicks, Mark; Hamlyn, Penny; Lee, L Andrew; Kates, Patrick A

Year: 2026

Venue: New biotechnology

DOI: https://doi.org/10.1016/j.nbt.2025.11.004

Paper A novel application of ion exchange chromatography in recombinant hepatitis B vaccine downstream processing: Improving recombinant HBsAg homogeneity by removing associated aggregates.

Kimia, Zeinab; Hosseini, Seyed Nezamedin; Ashraf Talesh, Seyed Siamak et al. · 2019 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · DOI

Full title: A novel application of ion exchange chromatography in recombinant hepatitis B vaccine downstream processing: Improving recombinant HBsAg homogeneity by removing associated aggregates.

Authors: Kimia, Zeinab; Hosseini, Seyed Nezamedin; Ashraf Talesh, Seyed Siamak; Khatami, Maryam; Kavianpour, Alireza; Javidanbardan, Amin

Year: 2019

Venue: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

DOI: https://doi.org/10.1016/j.jchromb.2019.03.009

Paper One-step integrated clarification and purification of a monoclonal antibody using Protein A Mag Sepharose beads and a cGMP-compliant high-gradient magnetic separator.

Ebeler, Moritz; Lind, Ola; Norrman, Nils et al. · 2018 · New biotechnology · DOI

Full title: One-step integrated clarification and purification of a monoclonal antibody using Protein A Mag Sepharose beads and a cGMP-compliant high-gradient magnetic separator.

Authors: Ebeler, Moritz; Lind, Ola; Norrman, Nils; Palmgren, Ronnie; Franzreb, Matthias

Year: 2018

Venue: New biotechnology

DOI: https://doi.org/10.1016/j.nbt.2018.02.007

Paper Improved Production and Characterization of Recombinant Human Granulocyte Colony Stimulating Factor from E. coli under Optimized Downstream Processes.

Vemula, Sandeep; Thunuguntla, Rahul; Dedaniya, Akshay et al. · 2015 · Protein expression and purification · DOI

Full title: Improved Production and Characterization of Recombinant Human Granulocyte Colony Stimulating Factor from E. coli under Optimized Downstream Processes.

Authors: Vemula, Sandeep; Thunuguntla, Rahul; Dedaniya, Akshay; Kokkiligadda, Sujana; Palle, Chaitanya; Ronda, Srinivasa Reddy

Year: 2015

Venue: Protein expression and purification

DOI: https://doi.org/10.1016/j.pep.2015.01.010

Paper Mini review for niche downstream processes.

Arakawa, Tsutomu; Ejima, Daisuke; Tomioka, Yui et al. · 2025 · Protein expression and purification · DOI

Full title: Mini review for niche downstream processes.

Authors: Arakawa, Tsutomu; Ejima, Daisuke; Tomioka, Yui; Sakuma, Chiaki; Akuta, Teruo

Year: 2025

Venue: Protein expression and purification

DOI: https://doi.org/10.1016/j.pep.2025.106690

Paper Evaluating the efficacy of immobilized metal affinity chromatography (IMAC) for host cell protein (HCP) removal from anti-HER2 scFv expressed in Escherichia coli.

Soltaninasab, Saba; Ahmadzadeh, Maryam; Shahhosseini, Soraya et al. · 2022 · Protein expression and purification · DOI

Full title: Evaluating the efficacy of immobilized metal affinity chromatography (IMAC) for host cell protein (HCP) removal from anti-HER2 scFv expressed in Escherichia coli.

Authors: Soltaninasab, Saba; Ahmadzadeh, Maryam; Shahhosseini, Soraya; Mohit, Elham

Year: 2022

Venue: Protein expression and purification

DOI: https://doi.org/10.1016/j.pep.2021.106004

Paper A highly efficient integrated chromatographic procedure for the purification of recombinant hepatitis B surface antigen from Hansenula polymorpha.

Huang, Yongdong; Bi, Jingxiu; Zhang, Yan et al. · 2007 · Protein expression and purification · DOI

Full title: A highly efficient integrated chromatographic procedure for the purification of recombinant hepatitis B surface antigen from Hansenula polymorpha.

Authors: Huang, Yongdong; Bi, Jingxiu; Zhang, Yan; Zhou, Weibin; Li, Yan; Zhao, Lan; Su, Zhiguo

Year: 2007

Venue: Protein expression and purification

DOI: https://doi.org/10.1016/j.pep.2007.08.009

Paper Recovery of value-added products from wastewater using Aqueous Two-Phase Systems - A review.

Varadavenkatesan, Thivaharan; Pai, Shraddha; Vinayagam, Ramesh et al. · 2021 · The Science of the total environment · DOI

Full title: Recovery of value-added products from wastewater using Aqueous Two-Phase Systems - A review.

Authors: Varadavenkatesan, Thivaharan; Pai, Shraddha; Vinayagam, Ramesh; Pugazhendhi, Arivalagan; Selvaraj, Raja

Year: 2021

Venue: The Science of the total environment

DOI: https://doi.org/10.1016/j.scitotenv.2021.146293

Paper Effective strategies for host cell protein clearance in downstream processing of monoclonal antibodies and Fc-fusion proteins.

Li, Yifeng · 2017 · Protein expression and purification · DOI

Full title: Effective strategies for host cell protein clearance in downstream processing of monoclonal antibodies and Fc-fusion proteins.

Authors: Li, Yifeng

Year: 2017

Venue: Protein expression and purification

DOI: https://doi.org/10.1016/j.pep.2017.04.006

Paper Downstream processing of a plant-derived malaria transmission-blocking vaccine candidate.

Menzel, Stephan; Holland, Tanja; Boes, Alexander et al. · 2018 · Protein expression and purification · DOI

Full title: Downstream processing of a plant-derived malaria transmission-blocking vaccine candidate.

Authors: Menzel, Stephan; Holland, Tanja; Boes, Alexander; Spiegel, Holger; Fischer, Rainer; Buyel, Johannes Felix

Year: 2018

Venue: Protein expression and purification

DOI: https://doi.org/10.1016/j.pep.2018.07.012

Paper Chromatography-free recovery of biopharmaceuticals through aqueous two-phase processing.

Azevedo, Ana M; Rosa, Paula A J; Ferreira, I Filipa et al. · 2009 · Trends in biotechnology · DOI

Full title: Chromatography-free recovery of biopharmaceuticals through aqueous two-phase processing.

Authors: Azevedo, Ana M; Rosa, Paula A J; Ferreira, I Filipa; Aires-Barros, M Raquel

Year: 2009

Venue: Trends in biotechnology

DOI: https://doi.org/10.1016/j.tibtech.2009.01.004

Paper Continuous downstream processing of biopharmaceuticals.

Jungbauer, Alois · 2013 · Trends in biotechnology · DOI

Full title: Continuous downstream processing of biopharmaceuticals.

Authors: Jungbauer, Alois

Year: 2013

Venue: Trends in biotechnology

DOI: https://doi.org/10.1016/j.tibtech.2013.05.011

Paper Purification of cell culture-derived influenza A virus via continuous anion exchange chromatography on monoliths.

Fischer, Laura M; Wolff, Michael W; Reichl, Udo · 2018 · Vaccine · DOI

Full title: Purification of cell culture-derived influenza A virus via continuous anion exchange chromatography on monoliths.

Authors: Fischer, Laura M; Wolff, Michael W; Reichl, Udo

Year: 2018

Venue: Vaccine

DOI: https://doi.org/10.1016/j.vaccine.2017.06.086

Paper Purification and functional characterization of gag-spike virus-like particles: Process optimization for efficient vaccine production.

Gashti, Anahita Bakhshizadeh; Patel, Mehul; Chahal, Parminder Singh et al. · 2025 · Vaccine · DOI

Full title: Purification and functional characterization of gag-spike virus-like particles: Process optimization for efficient vaccine production.

Authors: Gashti, Anahita Bakhshizadeh; Patel, Mehul; Chahal, Parminder Singh; Hrapovic, Sabahudin; Gilbert, Rénald; Morasse, Audrey; Nassoury, Nasha; Tiwari, Krishnaraj

Year: 2025

Venue: Vaccine

DOI: https://doi.org/10.1016/j.vaccine.2025.127500

Paper Modeling of purification operations in biotechnology: enabling process development, optimization, and scale-up.

Velayudhan, Ajoy; Menon, Manoj K · 2007 · Biotechnology progress · DOI

Full title: Modeling of purification operations in biotechnology: enabling process development, optimization, and scale-up.

Authors: Velayudhan, Ajoy; Menon, Manoj K

Year: 2007

Venue: Biotechnology progress

DOI: https://doi.org/10.1021/bp060378m

Paper Host Cell Protein Profiling by Targeted and Untargeted Analysis of Data Independent Acquisition Mass Spectrometry Data with Parallel Reaction Monitoring Verification.

Kreimer, Simion; Gao, Yuanwei; Ray, Somak et al. · 2017 · Analytical chemistry · DOI

Full title: Host Cell Protein Profiling by Targeted and Untargeted Analysis of Data Independent Acquisition Mass Spectrometry Data with Parallel Reaction Monitoring Verification.

Authors: Kreimer, Simion; Gao, Yuanwei; Ray, Somak; Jin, Mi; Tan, Zhijun; Mussa, Nesredin A; Tao, Li; Li, Zhengjian; Ivanov, Alexander R; Karger, Barry L

Year: 2017

Venue: Analytical chemistry

DOI: https://doi.org/10.1021/acs.analchem.6b04892

Paper Label-Free Potentiometric Ion Flux Immunosensor for Determination of Recombinant Human Myelin Basic Protein: Application to Downstream Purification from Transgenic Milk.

Al-Ghobashy, Medhat A; Nadim, Ahmed H; El-Sayed, Ghada M et al. · 2019 · ACS sensors · DOI

Full title: Label-Free Potentiometric Ion Flux Immunosensor for Determination of Recombinant Human Myelin Basic Protein: Application to Downstream Purification from Transgenic Milk.

Authors: Al-Ghobashy, Medhat A; Nadim, Ahmed H; El-Sayed, Ghada M; Nebsen, Marianne

Year: 2019

Venue: ACS sensors

DOI: https://doi.org/10.1021/acssensors.8b01315

Paper Magnetic One-Step Purification of His-Tagged Protein by Bare Iron Oxide Nanoparticles.

Schwaminger, Sebastian P; Fraga-García, Paula; Blank-Shim, Silvia A et al. · 2019 · ACS omega · DOI

Full title: Magnetic One-Step Purification of His-Tagged Protein by Bare Iron Oxide Nanoparticles.

Authors: Schwaminger, Sebastian P; Fraga-García, Paula; Blank-Shim, Silvia A; Straub, Tamara; Haslbeck, Martin; Muraca, Francesco; Dawson, Kenneth A; Berensmeier, Sonja

Year: 2019

Venue: ACS omega

DOI: https://doi.org/10.1021/acsomega.8b03348

Paper Purification of recombinant baculoviruses for gene therapy using membrane processes.

Vicente, T; Peixoto, C; Carrondo, M J T et al. · 2009 · Gene therapy · DOI

Full title: Purification of recombinant baculoviruses for gene therapy using membrane processes.

Authors: Vicente, T; Peixoto, C; Carrondo, M J T; Alves, P M

Year: 2009

Venue: Gene therapy

DOI: https://doi.org/10.1038/gt.2009.33

Paper Process characterization for metal-affinity chromatography of an Fc fusion protein: a design-of-experiments approach.

Shukla, A A; Sorge, L; Boldman, J et al. · 2001 · Biotechnology and applied biochemistry · DOI

Full title: Process characterization for metal-affinity chromatography of an Fc fusion protein: a design-of-experiments approach.

Authors: Shukla, A A; Sorge, L; Boldman, J; Waugh, S

Year: 2001

Venue: Biotechnology and applied biochemistry

DOI: https://doi.org/10.1042/ba20010019

Paper Design of a filter train for precipitate removal in monoclonal antibody downstream processing.

Kandula, Sunitha; Babu, Sudha; Jin, Mi et al. · 2009 · Biotechnology and applied biochemistry · DOI

Full title: Design of a filter train for precipitate removal in monoclonal antibody downstream processing.

Authors: Kandula, Sunitha; Babu, Sudha; Jin, Mi; Shukla, Abhinav A

Year: 2009

Venue: Biotechnology and applied biochemistry

DOI: https://doi.org/10.1042/BA20090181

Paper Downstream processing of lactoperoxidase from milk whey by involving liquid emulsion membrane.

Priyanka, B S; Rastogi, Navin K · 2018 · Preparative biochemistry & biotechnology · DOI

Full title: Downstream processing of lactoperoxidase from milk whey by involving liquid emulsion membrane.

Authors: Priyanka, B S; Rastogi, Navin K

Year: 2018

Venue: Preparative biochemistry & biotechnology

DOI: https://doi.org/10.1080/10826068.2018.1425713

Paper Downstream protein separation by surfactant precipitation: a review.

Wong, Fadzlie Wong Faizal; Ariff, Arbakariya B; Stuckey, David C · 2018 · Critical reviews in biotechnology · DOI

Full title: Downstream protein separation by surfactant precipitation: a review.

Authors: Wong, Fadzlie Wong Faizal; Ariff, Arbakariya B; Stuckey, David C

Year: 2018

Venue: Critical reviews in biotechnology

DOI: https://doi.org/10.1080/07388551.2017.1312266

Paper An overview of cell disruption methods for intracellular biomolecules recovery.

Gomes, Tatiane Aparecida; Zanette, Cristina Maria; Spier, Michele Rigon · 2020 · Preparative biochemistry & biotechnology · DOI

Full title: An overview of cell disruption methods for intracellular biomolecules recovery.

Authors: Gomes, Tatiane Aparecida; Zanette, Cristina Maria; Spier, Michele Rigon

Year: 2020

Venue: Preparative biochemistry & biotechnology

DOI: https://doi.org/10.1080/10826068.2020.1728696

Paper Polyethylene glycol precipitation: fundamentals and recent advances.

Pons Royo, Maria Del Carme; Jungbauer, Alois · 2025 · Preparative biochemistry & biotechnology · DOI

Full title: Polyethylene glycol precipitation: fundamentals and recent advances.

Authors: Pons Royo, Maria Del Carme; Jungbauer, Alois

Year: 2025

Venue: Preparative biochemistry & biotechnology

DOI: https://doi.org/10.1080/10826068.2025.2470220

Paper Current trends and challenges in the downstream purification of bispecific antibodies.

Chen, Serene W; Zhang, Wei · 2021 · Antibody therapeutics · DOI

Full title: Current trends and challenges in the downstream purification of bispecific antibodies.

Authors: Chen, Serene W; Zhang, Wei

Year: 2021

Venue: Antibody therapeutics

DOI: https://doi.org/10.1093/abt/tbab007

Paper Flocculation increases the efficacy of depth filtration during the downstream processing of recombinant pharmaceutical proteins produced in tobacco.

Buyel, Johannes F; Fischer, Rainer · 2014 · Plant biotechnology journal · DOI

Full title: Flocculation increases the efficacy of depth filtration during the downstream processing of recombinant pharmaceutical proteins produced in tobacco.

Authors: Buyel, Johannes F; Fischer, Rainer

Year: 2014

Venue: Plant biotechnology journal

DOI: https://doi.org/10.1111/pbi.12132

Paper Cationic polymer precipitation for enhanced impurity removal in downstream processing.

Li, Zhao; Chen, Justin; Martinez-Fonts, Kirby et al. · 2023 · Biotechnology and bioengineering · DOI

Full title: Cationic polymer precipitation for enhanced impurity removal in downstream processing.

Authors: Li, Zhao; Chen, Justin; Martinez-Fonts, Kirby; Rauscher, Michael; Rivera, Shannon; Welsh, John; Kandula, Sunitha

Year: 2023

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28416

Paper High-performance countercurrent membrane purification for host cell protein removal from monoclonal antibody products.

Mohammadzadehmarandi, Aylin; Determan, Amy; Krumm, Christian et al. · 2023 · Biotechnology and bioengineering · DOI

Full title: High-performance countercurrent membrane purification for host cell protein removal from monoclonal antibody products.

Authors: Mohammadzadehmarandi, Aylin; Determan, Amy; Krumm, Christian; McIntosh, Lucas D; Zydney, Andrew L

Year: 2023

Venue: Biotechnology and bioengineering

DOI: https://doi.org/10.1002/bit.28531

Paper Advective hydrogel membrane chromatography for monoclonal antibody purification in bioprocessing.

Hou, Ying; Brower, Mark; Pollard, David et al. · 2015 · Biotechnology progress · DOI

Full title: Advective hydrogel membrane chromatography for monoclonal antibody purification in bioprocessing.

Authors: Hou, Ying; Brower, Mark; Pollard, David; Kanani, Dharmesh; Jacquemart, Renaud; Kachuik, Bradley; Stout, James

Year: 2015

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2113

Paper Accounting for host cell protein behavior in anion-exchange chromatography.

Swanson, Ryan K; Xu, Ruo; Nettleton, Daniel S et al. · 2016 · Biotechnology progress · DOI

Full title: Accounting for host cell protein behavior in anion-exchange chromatography.

Authors: Swanson, Ryan K; Xu, Ruo; Nettleton, Daniel S; Glatz, Charles E

Year: 2016

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2342

Paper High-throughput process development of purification alternatives for the protein avidin.

Diederich, Patrick; Hoffmann, Marc; Hubbuch, Jürgen · 2015 · Biotechnology progress · DOI

Full title: High-throughput process development of purification alternatives for the protein avidin.

Authors: Diederich, Patrick; Hoffmann, Marc; Hubbuch, Jürgen

Year: 2015

Venue: Biotechnology progress

DOI: https://doi.org/10.1002/btpr.2104

Paper Integrated downstream processing of lactoperoxidase from milk whey involving aqueous two-phase extraction and ultrasound-assisted ultrafiltration.

Nandini, K E; Rastogi, Navin K · 2011 · Applied biochemistry and biotechnology · DOI

Full title: Integrated downstream processing of lactoperoxidase from milk whey involving aqueous two-phase extraction and ultrasound-assisted ultrafiltration.

Authors: Nandini, K E; Rastogi, Navin K

Year: 2011

Venue: Applied biochemistry and biotechnology

DOI: https://doi.org/10.1007/s12010-010-9026-9

Paper In silico mediated workflow for rapid development of downstream processing: Orthogonal product-related impurity removal for a Fc-containing therapeutic.

Jang, Dongyoun; Altern, Scott H; Cramer, Steven M · 2024 · Journal of chromatography. A · DOI

Full title: In silico mediated workflow for rapid development of downstream processing: Orthogonal product-related impurity removal for a Fc-containing therapeutic.

Authors: Jang, Dongyoun; Altern, Scott H; Cramer, Steven M

Year: 2024

Venue: Journal of chromatography. A

DOI: https://doi.org/10.1016/j.chroma.2024.465281

Paper Application of semi-industrial monolithic columns for downstream processing of clotting factor IX.

Branović, K; Buchacher, A; Barut, M et al. · 2003 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · DOI

Full title: Application of semi-industrial monolithic columns for downstream processing of clotting factor IX.

Authors: Branović, K; Buchacher, A; Barut, M; Strancar, A; Josic, Djuro

Year: 2003

Venue: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

DOI: https://doi.org/10.1016/s1570-0232(03)00095-3

Paper Peptide binding to metal oxide nanoparticles.

Schwaminger, S P; Blank-Shim, S A; Scheifele, I et al. · 2017 · Faraday discussions · DOI

Full title: Peptide binding to metal oxide nanoparticles.

Authors: Schwaminger, S P; Blank-Shim, S A; Scheifele, I; Fraga-García, P; Berensmeier, S

Year: 2017

Venue: Faraday discussions

DOI: https://doi.org/10.1039/c7fd00105c

Paper [Optimization and application of caprylic acid precipitation in the purification of monoclonal antibody].

Yang, Zhonghua; Zhou, Jianqin · 2023 · Sheng wu gong cheng xue bao = Chinese journal of biotechnology · DOI

Full title: [Optimization and application of caprylic acid precipitation in the purification of monoclonal antibody].

Authors: Yang, Zhonghua; Zhou, Jianqin

Year: 2023

Venue: Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI: https://doi.org/10.13345/j.cjb.220882

Paper One-step purification of twin-strep-tagged proteins and their complexes on strep-tactin resin cross-linked with bis(sulfosuccinimidyl) suberate (BS3).

Ivanov, Konstantin I; Bašić, Marta; Varjosalo, Markku et al. · 2014 · Journal of visualized experiments : JoVE · DOI

Full title: One-step purification of twin-strep-tagged proteins and their complexes on strep-tactin resin cross-linked with bis(sulfosuccinimidyl) suberate (BS3).

Authors: Ivanov, Konstantin I; Bašić, Marta; Varjosalo, Markku; Mäkinen, Kristiina

Year: 2014

Venue: Journal of visualized experiments : JoVE

DOI: https://doi.org/10.3791/51536

Thesis The Transition from Resin Chromatography to Membrane Adsorbers for Protein Separations at Industrial Scale

Qu, Y; Bekard, I; Hunt, B et al. · 2023 · University of Melbourne · DOI

Full title: The Transition from Resin Chromatography to Membrane Adsorbers for Protein Separations at Industrial Scale

Authors: Qu, Y; Bekard, I; Hunt, B; Black, J; Fabri, L; Gras, SL; Kentish, SE

Year: 2023

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/338280

Thesis Single-objective robust optimisation in bioprocessing with conformalised quantile regression as interval-based surrogate models

Pham, TD; Bassett, R; Aickelin, U · 2025 · University of Melbourne · DOI

Full title: Single-objective robust optimisation in bioprocessing with conformalised quantile regression as interval-based surrogate models

Authors: Pham, TD; Bassett, R; Aickelin, U

Year: 2025

Venue: University of Melbourne

DOI: https://hdl.handle.net/11343/361033

Thesis Protein isolation using affinity chromatography

Besselink, T. · 2012 · Wageningen University & Research · DOI

Full title: Protein isolation using affinity chromatography

Authors: Besselink, T.

Year: 2012

Venue: Wageningen University & Research

DOI: https://research.wur.nl/en/publications/protein-isolation-using-affinity-chromatography

Thesis A multi-column plate adapter provides an economical and versatile high-throughput protein purification system

Dominguez, Matthew J; Lantz, Benjamin J; Rhode, Rebecca J et al. · 2018 · University of Liverpool · DOI

Full title: A multi-column plate adapter provides an economical and versatile high-throughput protein purification system

Authors: Dominguez, Matthew J; Lantz, Benjamin J; Rhode, Rebecca J; Sharp, Zoey L; Finney, Krysten C; Martinez, Valeria Jaramillo; Stollar, Elliott J

Year: 2018

Venue: University of Liverpool

DOI: https://livrepository.liverpool.ac.uk/3048195/1/E%20Stollar%20-%20A%20multi-column%20plate%20adapter%20provides%20an%20economical%20and%20versatile%20high-throughput%20protein%20purification%20system%20-%20AAM.docx

Thesis Modeling & Simulation of Affinity Chromatography & Investigation of CaptureSMB

Bogren, Dennis · 2018 · Lund University Student Papers · DOI

Full title: Modeling & Simulation of Affinity Chromatography & Investigation of CaptureSMB

Authors: Bogren, Dennis

Year: 2018

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/8951165

Thesis Modelling and simulation of antibody purification

Perez Serrano, Ferran · 2014 · Lund University Student Papers · DOI

Full title: Modelling and simulation of antibody purification

Authors: Perez Serrano, Ferran

Year: 2014

Venue: Lund University Student Papers

DOI: http://lup.lub.lu.se/student-papers/record/4865142

Thesis High-gradient magnetic separation for technical scale protein recovery using low cost magnetic nanoparticles

P. Fraga García; M. Brammen; M. Wolf et al. · 2015 · Technical University of Munich (TUM) · DOI

Full title: High-gradient magnetic separation for technical scale protein recovery using low cost magnetic nanoparticles

Authors: P. Fraga García; M. Brammen; M. Wolf; S. Reinlein; M. Freiherr von Roman; S. Berensmeier

Year: 2015

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1272987

Thesis Protein A Affinity Precipitation of Human Immunoglobulin G

L. Janoschek; M. Freiherr von Roman; S. Berensmeier · 2014 · Technical University of Munich (TUM) · DOI

Full title: Protein A Affinity Precipitation of Human Immunoglobulin G

Authors: L. Janoschek; M. Freiherr von Roman; S. Berensmeier

Year: 2014

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1224553

Thesis Design of affinity tags for bare magnetic nanoparticles

Blank-Shim, Silvia Angela · 2018 · Technical University of Munich (TUM) · DOI

Full title: Design of affinity tags for bare magnetic nanoparticles

Authors: Blank-Shim, Silvia Angela

Year: 2018

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1402568

Thesis Peptide binding to metal oxide nanoparticles

Schwaminger SP, Blank-Shim SA, Scheifele I, Fraga-García P, Berensmeier S: · 2017 · Technical University of Munich (TUM) · DOI

Full title: Peptide binding to metal oxide nanoparticles

Authors: Schwaminger SP, Blank-Shim SA, Scheifele I, Fraga-García P, Berensmeier S:

Year: 2017

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1401251

Thesis Bioseparation, Magnetic Particle Adsorbents

Urs Alexander Peuker; Owen Thomas; Timothy John Hobley et al. · 2010 · Technical University of Munich (TUM) · DOI

Full title: Bioseparation, Magnetic Particle Adsorbents

Authors: Urs Alexander Peuker; Owen Thomas; Timothy John Hobley; Matthias Franzreb; Sonja Berensmeier; Maria Schäfer; Birgit Hickstein

Year: 2010

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1232872

Thesis Non-chromatographic preparative purification of enhanced green fluorescent protei

Hekmat, Dariusch; Maslak, Dominik; Freiherr von Roman, Matthias et al. · 2015 · Technical University of Munich (TUM) · DOI

Full title: Non-chromatographic preparative purification of enhanced green fluorescent protei

Authors: Hekmat, Dariusch; Maslak, Dominik; Freiherr von Roman, Matthias; Breitschwerdt, Peter; Ströhle, Christoph; Vogt, Alexander; Berensmeier, Sonja; Weuster-Botz, Dirk

Year: 2015

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1247196

Thesis An optimized purification process for porcine gastric mucin with preservation of its native functional properties

Schömig VJ, Käsdorf BT, Scholz C, Bidmon K, Lieleg O, Berensmeier S: · 2016 · Technical University of Munich (TUM) · DOI

Full title: An optimized purification process for porcine gastric mucin with preservation of its native functional properties

Authors: Schömig VJ, Käsdorf BT, Scholz C, Bidmon K, Lieleg O, Berensmeier S:

Year: 2016

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1306290

Thesis Isolation of biofunctional bovine immunoglobulin G from milk- and colostral whey with mixed-mode chromatography at lab and pilot scale

Heidebrecht, H.-J.; Kainz, B.; Schopf, R. et al. · 2018 · Technical University of Munich (TUM) · DOI

Full title: Isolation of biofunctional bovine immunoglobulin G from milk- and colostral whey with mixed-mode chromatography at lab and pilot scale

Authors: Heidebrecht, H.-J.;Kainz, B.;Schopf, R.;Godl, K.;Karcier, Z.;Kulozik, U.;Förster, B.

Year: 2018

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1462726

Thesis Fractionation of α-lactalbumin and β-lactoglobulin from whey protein isolate using selective thermal aggregation, an optimized membrane separation procedure and resolubilization techniques at pilot plant scale

Toro-Sierra, J.; Tolkach, A.; Kulozik, U. · 2013 · Technical University of Munich (TUM) · DOI

Full title: Fractionation of α-lactalbumin and β-lactoglobulin from whey protein isolate using selective thermal aggregation, an optimized membrane separation procedure and resolubilization techniques at pilot plant scale

Authors: Toro-Sierra, J.;Tolkach, A.;Kulozik, U.

Year: 2013

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1469943

Thesis Impact of the iron saturation of bovine lactoferrin on adsorption to a strong cation exchanger membrane

Voswinkel, L.; Vogel, T.; Kulozik, U. · 2016 · Technical University of Munich (TUM) · DOI

Full title: Impact of the iron saturation of bovine lactoferrin on adsorption to a strong cation exchanger membrane

Authors: Voswinkel, L.;Vogel, T.;Kulozik, U.

Year: 2016

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1469869

Thesis Impact of the substrate viscosity, potentially interfering proteins and further sample characteristics on the ion exchange efficiency of tangential flow membrane adsorbers

Brand, J.; Kulozik, U.; Brand, Janina et al. · 2017 · Technical University of Munich (TUM) · DOI

Full title: Impact of the substrate viscosity, potentially interfering proteins and further sample characteristics on the ion exchange efficiency of tangential flow membrane adsorbers

Authors: Brand, J.;Kulozik, U.;Brand, Janina;Kulozik, Ulrich

Year: 2017

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1467575

Thesis Selective release of overexpressed recombinant proteins from E. coli cells facilitates one-step chromatographic purification of peptide-tagged green fluorescent protein variants

Kaveh-Baghbaderani Y, Blank-Shim SA, Koch T, Berensmeier S: · 2018 · Technical University of Munich (TUM) · DOI

Full title: Selective release of overexpressed recombinant proteins from E. coli cells facilitates one-step chromatographic purification of peptide-tagged green fluorescent protein variants

Authors: Kaveh-Baghbaderani Y, Blank-Shim SA, Koch T, Berensmeier S:

Year: 2018

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1468923

Thesis An optimized purification process for porcine gastric mucin with preservation of its native functional properties

Schömig, Veronika J.; Käsdorf, Benjamin T.; Scholz, Christoph et al. · 2016 · Technical University of Munich (TUM) · DOI

Full title: An optimized purification process for porcine gastric mucin with preservation of its native functional properties

Authors: Schömig, Veronika J.;Käsdorf, Benjamin T.;Scholz, Christoph;Bidmon, Konstantinia;Lieleg, Oliver;Berensmeier, Sonja

Year: 2016

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1308339

Thesis A novel approach for lysozyme and ovotransferrin fractionation from egg white by radial flow membrane adsorption chromatography: Impact of product and process variables

Brand, J.; Dachmann, E.; Pichler, M. et al. · 2016 · Technical University of Munich (TUM) · DOI

Full title: A novel approach for lysozyme and ovotransferrin fractionation from egg white by radial flow membrane adsorption chromatography: Impact of product and process variables

Authors: Brand, J.;Dachmann, E.;Pichler, M.;Lotz, S.;Kulozik, U.

Year: 2016

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1469892

Thesis Separation of glycossylated caseinomacropeptide at pilot scale using membrane adsorption in direct-capture mode

Kreuß, M.; Kulozik, U. · 2009 · Technical University of Munich (TUM) · DOI

Full title: Separation of glycossylated caseinomacropeptide at pilot scale using membrane adsorption in direct-capture mode

Authors: Kreuß, M.;Kulozik, U.

Year: 2009

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1475420

Thesis Magnetic one-step purification of his-tagged protein by bare iron oxide nanoparticles

Schwaminger SP, Fraga-García P, Blank-Shim SA, Straub T, Haslbeck M, Muraca F, Dawson KA, Berensmeier S: · 2019 · Technical University of Munich (TUM) · DOI

Full title: Magnetic one-step purification of his-tagged protein by bare iron oxide nanoparticles

Authors: Schwaminger SP, Fraga-García P, Blank-Shim SA, Straub T, Haslbeck M, Muraca F, Dawson KA, Berensmeier S:

Year: 2019

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1507194

Thesis Purification of a peptide tagged protein via an affinity chromatographic process with underivatized silica

Rauwolf S, Steegmüller T, Schwaminger SP, Berensmeier S: · 2021 · Technical University of Munich (TUM) · DOI

Full title: Purification of a peptide tagged protein via an affinity chromatographic process with underivatized silica

Authors: Rauwolf S, Steegmüller T, Schwaminger SP, Berensmeier S:

Year: 2021

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1615008

Thesis Design of interactions between nanomaterials and proteins: A highly affine peptide tag to bare iron oxide nanoparticles for magnetic protein separation

Schwaminger SP, Blank-Shim SA, Scheifele I, Pipich V, Fraga-García P, Berensmeier S: · 2019 · Technical University of Munich (TUM) · DOI

Full title: Design of interactions between nanomaterials and proteins: A highly affine peptide tag to bare iron oxide nanoparticles for magnetic protein separation

Authors: Schwaminger SP, Blank-Shim SA, Scheifele I, Pipich V, Fraga-García P, Berensmeier S:

Year: 2019

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1507200

Thesis Magnetic Separation in Bioprocessing Beyond the Analytical Scale: From Biotechnology to the Food Industry

Schwaminger SP, Fraga-García P, Eigenfeld M, Becker T, Berensmeier S: · 2019 · Technical University of Munich (TUM) · DOI

Full title: Magnetic Separation in Bioprocessing Beyond the Analytical Scale: From Biotechnology to the Food Industry

Authors: Schwaminger SP, Fraga-García P, Eigenfeld M, Becker T, Berensmeier S:

Year: 2019

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1538077

Thesis Seeking Innovative Affinity Approaches: A Performance Comparison between Magnetic Nanoparticle Agglomerates and Chromatography Resins for Antibody Recovery

Padwal P, Finger C, Fraga-García P, Kaveh-Baghbaderani Y, Schwaminger S, Berensmeier S: · 2020 · Technical University of Munich (TUM) · DOI

Full title: Seeking Innovative Affinity Approaches: A Performance Comparison between Magnetic Nanoparticle Agglomerates and Chromatography Resins for Antibody Recovery

Authors: Padwal P, Finger C, Fraga-García P, Kaveh-Baghbaderani Y, Schwaminger S, Berensmeier S:

Year: 2020

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1574653

Thesis Separation of aggregated β-lactoglobulin with optimised yield in a decanter centrifuge

Haller, Nicole; Greßlinger, Andreas Stefan; Kulozik, Ulrich · 2021 · Technical University of Munich (TUM) · DOI

Full title: Separation of aggregated β-lactoglobulin with optimised yield in a decanter centrifuge

Authors: Haller, Nicole;Greßlinger, Andreas Stefan;Kulozik, Ulrich

Year: 2021

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1615528

Thesis Single Pass Tangential Flow Filtration: Critical Operational Variables, Fouling, and Main Current Applications

Madsen, Emil; Kaiser, Johann; id_orcid 0000-0002-1383-6531 et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Single Pass Tangential Flow Filtration: Critical Operational Variables, Fouling, and Main Current Applications

Authors: Madsen, Emil; Kaiser, Johann; id_orcid 0000-0002-1383-6531; Krühne, Ulrich; id_orcid 0000-0001-7774-7442; Pinelo, Manuel; id_orcid 0000-0002-3944-6144

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/06747a88-6658-4d17-a11c-da11b8dd880c

Thesis P. pastoris (K. phaffi) perfusion processes: evaluation of cell retention techniques and integrated purification strategies

Linova, M.; id_orcid 0000-0001-7716-1257; Kodiripaka, S. et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: P. pastoris (K. phaffi) perfusion processes: evaluation of cell retention techniques and integrated purification strategies

Authors: Linova, M.; id_orcid 0000-0001-7716-1257; Kodiripaka, S.; Martins, E.; Pham, D.; id_orcid 0000-0002-7804-3882; Sripada, S.; Menegatti, S.; Carbonell, R.; Woodley, J.; id_orcid 0000-0002-7976-2483

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2d3b56e0-24f0-449e-bda9-fd8ea452eaaf

Thesis Purification of a monoclonal antibody using a novel high-capacity multimodal cation exchange nonwoven membrane

Fan, Jinxin; Sripada, Sobhana A.; Pham, Dan N. et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Purification of a monoclonal antibody using a novel high-capacity multimodal cation exchange nonwoven membrane

Authors: Fan, Jinxin; Sripada, Sobhana A.; Pham, Dan N.; id_orcid 0000-0002-7804-3882; Linova, Marina Y.; id_orcid 0000-0001-7716-1257; Woodley, John M.; id_orcid 0000-0002-7976-2483; Menegatti, Stefano; Boi, Cristiana; Carbonell, Ruben G.

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1a0d8bf1-9610-4ba3-9bbf-5ca351b1630c

Thesis Industrial ion-exchange chromatography development using discontinuous Galerkin methods coupled with forward sensitivity analysis

Meyer, Kristian; Søes Ibsen, Mikkel; Vetter-Joss, Lisa et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Industrial ion-exchange chromatography development using discontinuous Galerkin methods coupled with forward sensitivity analysis

Authors: Meyer, Kristian; Søes Ibsen, Mikkel; Vetter-Joss, Lisa; Broberg Hansen, Ernst; Abildskov, Jens; id_orcid 0000-0003-1187-8778

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1c9dec8d-f3aa-413b-9302-8256d46c6061

Thesis Recombinant Production of Human Aquaporin-1 to an Exceptional High Membrane Density in Saccharomyces cerevisiae .

Bomholt, Julie; Helix Nielsen, Claus; id_orcid 0000-0002-9392-7133 et al. · 2013 · Technical University of Denmark (DTU) · DOI

Full title: Recombinant Production of Human Aquaporin-1 to an Exceptional High Membrane Density in Saccharomyces cerevisiae .

Authors: Bomholt, Julie; Helix Nielsen, Claus; id_orcid 0000-0002-9392-7133; Scharff-Poulsen, Peter; Pedersen, Per Amstrup

Year: 2013

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/413ce303-b435-4e23-8270-b7f162f990e1

Thesis Dynamics of batch protein precipitation

Ehtesham, Amirkiarash; Sivaram, Abhishek; Siegel, Sara Danielle et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Dynamics of batch protein precipitation

Authors: Ehtesham, Amirkiarash; Sivaram, Abhishek; Siegel, Sara Danielle; Zanten, John van; Mansouri, Seyed Soheil; id_orcid 0000-0002-0924-4947

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/56926f26-9ec2-40d5-ac91-1efcabb0e012

Thesis Saccharomyces cerevisiae–Based Platform for Rapid Production and Evaluation of Eukaryotic Nutrient Transporters and Transceptors for Biochemical Studies and Crystallography

Scharff-Poulsen, Peter; Pedersen, Per Amstrup · 2013 · Technical University of Denmark (DTU) · DOI

Full title: Saccharomyces cerevisiae–Based Platform for Rapid Production and Evaluation of Eukaryotic Nutrient Transporters and Transceptors for Biochemical Studies and Crystallography

Authors: Scharff-Poulsen, Peter; Pedersen, Per Amstrup

Year: 2013

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/58d46e0d-9a20-4edc-8bad-e7c18e77a7a8

Thesis Pseudo-affinity capture of K. phaffii host cell proteins in flow-through mode: purification of protein therapeutics and proteomic study

Sripada, Sobhana A.; Elhanafi, Driss; Collins, Leonard B. et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Pseudo-affinity capture of K. phaffii host cell proteins in flow-through mode: purification of protein therapeutics and proteomic study

Authors: Sripada, Sobhana A.; Elhanafi, Driss; Collins, Leonard B.; Williams, Taufika I.; Linova, Marina Y.; id_orcid 0000-0001-7716-1257; Woodley, John M.; id_orcid 0000-0002-7976-2483; Boi, Cristiana; Menegatti, Stefano

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7581505e-4aa5-44f4-8a87-2f0ddf89bb09

Thesis Magnetic hydrophobic-charge induction adsorbents for the recovery of immunoglobulins from antiserum feedstocks by high-gradient magnetic fishing

Gomes, Cláudia Sofia Goncalves; Fashina, Adedayo; Fernández-Castané, Alfred et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Magnetic hydrophobic-charge induction adsorbents for the recovery of immunoglobulins from antiserum feedstocks by high-gradient magnetic fishing

Authors: Gomes, Cláudia Sofia Goncalves; Fashina, Adedayo; Fernández-Castané, Alfred; Overton, Timothy W; Hobley, Timothy John; id_orcid 0000-0002-1355-6214; Theodosiou, Eirini; Thomas, Owen R. T.

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bad1b658-578c-42d6-8964-1a38940109ba

Thesis Integrated Optimization of Hemoprotein Biomanufacturing in Yeast:From Upstream Engineering of Heme Synthesis to Downstream Purification of Human Hemoglobin

Frost, August Thinggaard · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Integrated Optimization of Hemoprotein Biomanufacturing in Yeast:From Upstream Engineering of Heme Synthesis to Downstream Purification of Human Hemoglobin

Authors: Frost, August Thinggaard

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/90f4acfb-2598-42d8-800d-78b35883fce1

Thesis Early-Stage In Silico Flowsheet Analysis for a Monoclonal Antibody Platform

Kaiser, Johann; id_orcid 0000-0002-1383-6531; Babi, Deenesh K. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Early-Stage In Silico Flowsheet Analysis for a Monoclonal Antibody Platform

Authors: Kaiser, Johann; id_orcid 0000-0002-1383-6531; Babi, Deenesh K.; Pinelo, Manuel; id_orcid 0000-0002-3944-6144; Krühne, Ulrich; id_orcid 0000-0001-7774-7442

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c3fbbf6b-2d0e-43ac-9387-8537778ebc8f

Thesis Optimizing protein-cell separation in submerged membrane bioreactor for clarification

Karki, Rebat; Skiadas, Ioannis V.; id_orcid 0000-0001-6183-4592 et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Optimizing protein-cell separation in submerged membrane bioreactor for clarification

Authors: Karki, Rebat; Skiadas, Ioannis V.; id_orcid 0000-0001-6183-4592; Woodley, John M.; id_orcid 0000-0002-7976-2483; Pinelo, Manuel; id_orcid 0000-0002-3944-6144

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d3e758c5-68ff-4a85-a40a-d984ecbacd53

Thesis Advanced purification strategy for CueR, a cysteine containing copper(I) and DNA binding protein

Balogh, Ria K.; Gyurcsik, Béla; Hunyadi-Gulyás, Éva et al. · 2016 · Technical University of Denmark (DTU) · DOI

Full title: Advanced purification strategy for CueR, a cysteine containing copper(I) and DNA binding protein

Authors: Balogh, Ria K.; Gyurcsik, Béla; Hunyadi-Gulyás, Éva; Christensen, Hans Erik Mølager; Jancsó, Attila

Year: 2016

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/baa71bce-9dba-4458-b232-8d3c1d08591f

Thesis Recombinant Production of Human Aquaporin-1 to an Exceptional High Membrane Density in Saccharomyces cerevisiae

Bomholt, Julie; Hélix-Nielsen, Claus; Scharff-Poulsen, Peter et al. · 2013 · University of Copenhagen · DOI

Full title: Recombinant Production of Human Aquaporin-1 to an Exceptional High Membrane Density in Saccharomyces cerevisiae

Authors: Bomholt, Julie; Hélix-Nielsen, Claus; Scharff-Poulsen, Peter; Pedersen, Per Amstrup

Year: 2013

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/00c801a5-ac4f-45e1-a154-aab3c3fb248d

Thesis Novel multimodal cation-exchange membrane for the purification of a single-chain variable fragment from Pichia pastoris supernatant

Pham, Dan N.; id_orcid 0000-0002-7804-3882; Linova, Marina Y. et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Novel multimodal cation-exchange membrane for the purification of a single-chain variable fragment from Pichia pastoris supernatant

Authors: Pham, Dan N.; id_orcid 0000-0002-7804-3882; Linova, Marina Y.; id_orcid 0000-0001-7716-1257; Smith, William K.; Brown, Hunter; Elhanafi, Driss; Fan, Jinxin; Lavoie, Joseph; Woodley, John M.; id_orcid 0000-0002-7976-2483; Carbonell, Ruben G.

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d389f2ef-aa9b-44aa-ab2a-6cc339b6945f

Thesis Lactococcus lactis provides an efficient platform for production of disulfide-rich recombinant proteins from Plasmodium falciparum

Singh, Susheel K; Tiendrebeogo, Régis Wendpayangde; Chourasia, Bishwanath Kumar et al. · 2018 · University of Copenhagen · DOI

Full title: Lactococcus lactis provides an efficient platform for production of disulfide-rich recombinant proteins from Plasmodium falciparum

Authors: Singh, Susheel K; Tiendrebeogo, Régis Wendpayangde; Chourasia, Bishwanath Kumar; Kana, Ikhlaq Hussain; Singh, Subhash; Theisen, Michael

Year: 2018

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/02eabcc6-e3fd-4b5c-bee8-dbbd5d5fe562

Thesis Evaluation of SinglePass Tangential Flow Filtration

Kaiser, Johann; id_orcid 0000-0002-1383-6531 · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Evaluation of SinglePass Tangential Flow Filtration

Authors: Kaiser, Johann; id_orcid 0000-0002-1383-6531

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e8b94114-f8d0-4eb6-91d0-605bba74497b

Thesis Industrial ion-exchange chromatography development using discontinuous Galerkin methods coupled with forward sensitivity analysis

Meyer, Kristian; Søes Ibsen, Mikkel; Vetter-Joss, Lisa et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Industrial ion-exchange chromatography development using discontinuous Galerkin methods coupled with forward sensitivity analysis

Authors: Meyer, Kristian; Søes Ibsen, Mikkel; Vetter-Joss, Lisa; Broberg Hansen, Ernst; Abildskov, Jens; id_orcid 0000-0003-1187-8778

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1c9dec8d-f3aa-413b-9302-8256d46c6061

Thesis Purification of a monoclonal antibody using a novel high-capacity multimodal cation exchange nonwoven membrane

Fan, Jinxin; Sripada, Sobhana A.; Pham, Dan N. et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Purification of a monoclonal antibody using a novel high-capacity multimodal cation exchange nonwoven membrane

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/1a0d8bf1-9610-4ba3-9bbf-5ca351b1630c

Thesis Single Pass Tangential Flow Filtration: Critical Operational Variables, Fouling, and Main Current Applications

Madsen, Emil; Kaiser, Johann; id_orcid 0000-0002-1383-6531 et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Single Pass Tangential Flow Filtration: Critical Operational Variables, Fouling, and Main Current Applications

Authors: Madsen, Emil; Kaiser, Johann; id_orcid 0000-0002-1383-6531; Krühne, Ulrich; id_orcid 0000-0001-7774-7442; Pinelo, Manuel; id_orcid 0000-0002-3944-6144

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/06747a88-6658-4d17-a11c-da11b8dd880c

Thesis Use of high-gradient magnetic fishing for reducing proteolysis during fermentation.

Maury, Trine Lütken; Ottow, Kim Ekelund; Brask, Jesper et al. · 2012 · Technical University of Denmark (DTU) · DOI

Full title: Use of high-gradient magnetic fishing for reducing proteolysis during fermentation.

Authors: Maury, Trine Lütken; Ottow, Kim Ekelund; Brask, Jesper; Villadsen, John; id_orcid 0000-0002-6523-8445; Hobley, Timothy John; id_orcid 0000-0002-1355-6214

Year: 2012

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/27058d31-3b4d-456c-b72f-6d3b9de85eb7

Thesis Saccharomyces cerevisiae -based platform for rapid production and evaluation of Eukaryotic Nutrient transporters and transceptors for biochemical studies and crystallography

Scharff-Poulsen, Peter; Pedersen, Per Amstrup · 2013 · University of Copenhagen · DOI

Full title: Saccharomyces cerevisiae -based platform for rapid production and evaluation of Eukaryotic Nutrient transporters and transceptors for biochemical studies and crystallography

Authors: Scharff-Poulsen, Peter; Pedersen, Per Amstrup

Year: 2013

Venue: University of Copenhagen

DOI: https://researchprofiles.ku.dk/da/publications/0c19fb8b-257f-44bf-95fc-4ecddafc549e

Thesis P. pastoris (K. phaffi) perfusion processes: evaluation of cell retention techniques and integrated purification strategies

Linova, M.; id_orcid 0000-0001-7716-1257; Kodiripaka, S. et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: P. pastoris (K. phaffi) perfusion processes: evaluation of cell retention techniques and integrated purification strategies

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/2d3b56e0-24f0-449e-bda9-fd8ea452eaaf

Thesis Demonstration of a strategy for product purification by high-gradient magnetic fishing: Recovery of superoxide dismutase from unconditioned whey

Meyer, A.; Hansen, D.B.; Goncalves Gomes, Claudia Sofia et al. · 2005 · Technical University of Denmark (DTU) · DOI

Full title: Demonstration of a strategy for product purification by high-gradient magnetic fishing: Recovery of superoxide dismutase from unconditioned whey

Authors: Meyer, A.; Hansen, D.B.; Goncalves Gomes, Claudia Sofia; Hobley, Timothy John; id_orcid 0000-0002-1355-6214; Thomas, Owen R. T.; Franzreb, M.

Year: 2005

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/52e17744-e1b0-44a3-956f-46bb906a12ff

Thesis Development, modelling, optimisation and scale-up of chromatographic purification of a therapeutic protein

Mollerup, Jørgen; Hansen, Thomas Budde; Kidal, Steffen et al. · 2007 · Technical University of Denmark (DTU) · DOI

Full title: Development, modelling, optimisation and scale-up of chromatographic purification of a therapeutic protein

Authors: Mollerup, Jørgen; Hansen, Thomas Budde; Kidal, Steffen; Sejergaard, Lars; Staby, Arne

Year: 2007

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4322cb55-ff05-44bb-a71a-65a9e5436acf

Thesis Recombinant Production of Human Aquaporin-1 to an Exceptional High Membrane Density in Saccharomyces cerevisiae .

Bomholt, Julie; Helix Nielsen, Claus; id_orcid 0000-0002-9392-7133 et al. · 2013 · Technical University of Denmark (DTU) · DOI

Full title: Recombinant Production of Human Aquaporin-1 to an Exceptional High Membrane Density in Saccharomyces cerevisiae .

Authors: Bomholt, Julie; Helix Nielsen, Claus; id_orcid 0000-0002-9392-7133; Scharff-Poulsen, Peter; Pedersen, Per Amstrup

Year: 2013

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/413ce303-b435-4e23-8270-b7f162f990e1

Thesis Dynamics of batch protein precipitation

Ehtesham, Amirkiarash; Sivaram, Abhishek; Siegel, Sara Danielle et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Dynamics of batch protein precipitation

Authors: Ehtesham, Amirkiarash; Sivaram, Abhishek; Siegel, Sara Danielle; Zanten, John van; Mansouri, Seyed Soheil; id_orcid 0000-0002-0924-4947

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/56926f26-9ec2-40d5-ac91-1efcabb0e012

Thesis High gradient magnetic separation versus expanded bed adsorption: a first principle comparison

Hubbuch, Jürgen; Matthiesen, D.B.; Hobley, Timothy John et al. · 2001 · Technical University of Denmark (DTU) · DOI

Full title: High gradient magnetic separation versus expanded bed adsorption: a first principle comparison

Authors: Hubbuch, Jürgen; Matthiesen, D.B.; Hobley, Timothy John; id_orcid 0000-0002-1355-6214; Thomas, Owen R. T.

Year: 2001

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/4462de0d-9040-49e0-bafb-fd214d5337ef

Thesis High-gradient magnetic affinity separation of trypsin from porcine pancreatin

Hubbuch, Jürgen; Thomas, Owen R. T. · 2002 · Technical University of Denmark (DTU) · DOI

Full title: High-gradient magnetic affinity separation of trypsin from porcine pancreatin

Authors: Hubbuch, Jürgen; Thomas, Owen R. T.

Year: 2002

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/724d5154-87ce-4266-ae09-766dfa140843

Thesis Use of Continuous Magnetic Extraction for removal of feedstock contaminants in flow-through mode

Paulus, Anja; Fischer, Ingo; Hobley, Timothy John et al. · 2014 · Technical University of Denmark (DTU) · DOI

Full title: Use of Continuous Magnetic Extraction for removal of feedstock contaminants in flow-through mode

Authors: Paulus, Anja; Fischer, Ingo; Hobley, Timothy John; id_orcid 0000-0002-1355-6214; Franzreb, Matthias

Year: 2014

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7c2b7274-40ad-40a0-9bb0-61dea52269eb

Thesis Engineering of the production of mannose-6-phosphate-modified lysosomal enzymes by the yeast Pichia pastoris

De Visscher, Charlotte · 2015 · Ghent University (Universiteit Gent) · DOI

Full title: Engineering of the production of mannose-6-phosphate-modified lysosomal enzymes by the yeast Pichia pastoris

Authors: De Visscher, Charlotte

Year: 2015

Venue: Ghent University (Universiteit Gent)

DOI: https://biblio.ugent.be/publication/5987332

Thesis Applications of cellulose-binding module fusion proteins: from bioactive filters to antibody purification

Hussack, Gregory John · 2020 · University of Guelph · DOI

Full title: Applications of cellulose-binding module fusion proteins: from bioactive filters to antibody purification

Authors: Hussack, Gregory John

Year: 2020

Venue: University of Guelph

DOI: https://hdl.handle.net/10214/22071

Thesis High-Temperature Short-Time Preserves Human Milk's Bioactive Proteins and Their Function Better Than Pasteurization Techniques With Long Processing Times

Kontopodi, Eva; Boeren, Sjef; Stahl, Bernd et al. · 2022 · Utrecht University · DOI

Full title: High-Temperature Short-Time Preserves Human Milk's Bioactive Proteins and Their Function Better Than Pasteurization Techniques With Long Processing Times

Authors: Kontopodi, Eva; Boeren, Sjef; Stahl, Bernd; van Goudoever, Johannes B; van Elburg, Ruurd M; Hettinga, Kasper

Year: 2022

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/418173

Thesis Experimental and theoretical study of matrix-assisted refolding

Zhang, Chun Yan · 2010 · Nanyang Technological University (NTU) · DOI

Full title: Experimental and theoretical study of matrix-assisted refolding

Authors: Zhang, Chun Yan

Year: 2010

Venue: Nanyang Technological University (NTU)

DOI: https://hdl.handle.net/10356/39800

Thesis High-Temperature Short-Time Preserves Human Milk's Bioactive Proteins and Their Function Better Than Pasteurization Techniques With Long Processing Times

Kontopodi, Eva; Boeren, Sjef; Stahl, Bernd et al. · 2022 · Utrecht University · DOI

Full title: High-Temperature Short-Time Preserves Human Milk's Bioactive Proteins and Their Function Better Than Pasteurization Techniques With Long Processing Times

Authors: Kontopodi, Eva; Boeren, Sjef; Stahl, Bernd; van Goudoever, Johannes B; van Elburg, Ruurd M; Hettinga, Kasper

Year: 2022

Venue: Utrecht University

DOI: https://dspace.library.uu.nl/handle/1874/419498

Thesis Development of a platform process for the production and purification of single‐domain antibodies

Crowell, Laura E; Goodwine, Chaz; Holt, Carla S et al. · 2021 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Development of a platform process for the production and purification of single‐domain antibodies

Authors: Crowell, Laura E; Goodwine, Chaz; Holt, Carla S; Rocha, Lucia; Vega, Celina; Rodriguez, Sergio A; Dalvie, Neil C; Tracey, Mary K; Puntel, Mariana; Wigdorovitz, Andrés; Parreño, Viviana; Love, Kerry R; Cramer, Steven M; Love, J Christopher

Year: 2021

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/135524

Thesis Steric accessibility of the N-terminus improves the titer and quality of recombinant proteins secreted from Komagataella phaffii

Dalvie, Neil C.; Naranjo, Christopher A.; Rodriguez-Aponte, Sergio A. et al. · 2022 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Steric accessibility of the N-terminus improves the titer and quality of recombinant proteins secreted from Komagataella phaffii

Authors: Dalvie, Neil C.; Naranjo, Christopher A.; Rodriguez-Aponte, Sergio A.; Johnston, Ryan S.; Christopher Love, J.

Year: 2022

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/145353

Thesis Minimal purification method enables developability assessment of recombinant proteins

Rodriguez‐Aponte, Sergio A; Naranjo, Christopher A; Johnston, Ryan S et al. · 2025 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Minimal purification method enables developability assessment of recombinant proteins

Authors: Rodriguez‐Aponte, Sergio A; Naranjo, Christopher A; Johnston, Ryan S; Dalvie, Neil C; Crowell, Laura E; Bajoria, Sakshi; Kumru, Ozan S; Joshi, Sangeeta B; Volkin, David B; Love, J Christopher

Year: 2025

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/163511

Thesis 3D printed platform stationary phases for downstream processing: development of porous platform inks, characterization of 3D printed chromatography columns and testing for industrial bioprocessing

Conti, Mariachiara · 2024 · The University of Edinburgh · DOI

Full title: 3D printed platform stationary phases for downstream processing: development of porous platform inks, characterization of 3D printed chromatography columns and testing for industrial bioprocessing

Authors: Conti, Mariachiara

Year: 2024

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/42110

Thesis Development of an efficient protein recovery system using liquid biphasic flotation

Sankaran, Revathy · 2018 · University of Nottingham · DOI

Full title: Development of an efficient protein recovery system using liquid biphasic flotation

Authors: Sankaran, Revathy

Year: 2018

Venue: University of Nottingham

DOI: https://eprints.nottingham.ac.uk/52235/1/Finalised%20thesis.pdf

Thesis 3D print your own chromatography column: material development and characterisation of ion exchange monoliths for protein purification

Simon, Ursula · 2021 · The University of Edinburgh · DOI

Full title: 3D print your own chromatography column: material development and characterisation of ion exchange monoliths for protein purification

Authors: Simon, Ursula

Year: 2021

Venue: The University of Edinburgh

DOI: https://hdl.handle.net/1842/37921

Thesis Extraction of haemoglobin from human blood by affinity precipitation using a haptoglobin-based stimuli-responsive affinity macroligand

Stocker-Majd, Gisela; Hilbrig, Frank; Freitag, Ruth · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Extraction of haemoglobin from human blood by affinity precipitation using a haptoglobin-based stimuli-responsive affinity macroligand

Authors: Stocker-Majd, Gisela; Hilbrig, Frank; Freitag, Ruth

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/61299

Thesis Influence of specific growth rate on specific productivity and glycosylation of a recombinant avidin produced by a Pichia pastoris Mut(+) strain

Schenk, Jonas; Balazs, Krisztina; Jungo, Carmen et al. · 2010 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Influence of specific growth rate on specific productivity and glycosylation of a recombinant avidin produced by a Pichia pastoris Mut(+) strain

Authors: Schenk, Jonas; Balazs, Krisztina; Jungo, Carmen; Urfer, Julien; Wegmann, Carole; Zocchi, Andrea; Marison, Ian W.; von Stockar, Urs

Year: 2010

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/58381

Thesis Experimental and numerical modelling comparative study of ion-exchange chromatography

Jozwik, Magdalena · 2005 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Experimental and numerical modelling comparative study of ion-exchange chromatography

Authors: Jozwik, Magdalena

Year: 2005

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/212196

Thesis Development of a downstream process for the isolation and separation of monoclonal immunoglobulin A monomers, dimers and polymers from cell culture supernatant

Luellau, Elke; von Stockar, Urs; Vogt, Sabine et al. · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Development of a downstream process for the isolation and separation of monoclonal immunoglobulin A monomers, dimers and polymers from cell culture supernatant

Authors: Luellau, Elke; von Stockar, Urs; Vogt, Sabine; Freitag, Ruth

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226026

Thesis Investigation of particle-based and monolithic columns for cation exchange protein displacement chromatography using poly(diallyl-dimethylammonium chloride) as displacer

Schmidt, Beata; Wandrey, Christine; Freitag, Ruth · 2006 · École polytechnique fédérale de Lausanne (EPFL) · DOI

Full title: Investigation of particle-based and monolithic columns for cation exchange protein displacement chromatography using poly(diallyl-dimethylammonium chloride) as displacer

Authors: Schmidt, Beata; Wandrey, Christine; Freitag, Ruth

Year: 2006

Venue: École polytechnique fédérale de Lausanne (EPFL)

DOI: https://infoscience.epfl.ch/handle/20.500.14299/226579

Thesis Isolation of lactoferrin and immunoglobulins from dairy whey by an electrodialysis with filtration membrane process

Wang, Q; Chen, GQ; Kentish, SE · 2019 · University of Melbourne · DOI

Full title: Isolation of lactoferrin and immunoglobulins from dairy whey by an electrodialysis with filtration membrane process

Authors: Wang, Q; Chen, GQ; Kentish, SE

Year: 2019

Venue: University of Melbourne

DOI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000490044400025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c

Thesis Efficient inclusion body processing using chemical extraction and high gradient magnetic fishing

Heebøll-Nielsen, Anders; Choe, W.S.; Middelberg, A.P.J. et al. · 2003 · Technical University of Denmark (DTU) · DOI

Full title: Efficient inclusion body processing using chemical extraction and high gradient magnetic fishing

Authors: Heebøll-Nielsen, Anders; Choe, W.S.; Middelberg, A.P.J.; Thomas, Owen R. T.

Year: 2003

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/8649e382-b740-45e2-920a-196e513618dc

Thesis Integrated Optimization of Hemoprotein Biomanufacturing in Yeast:From Upstream Engineering of Heme Synthesis to Downstream Purification of Human Hemoglobin

Frost, August Thinggaard · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Integrated Optimization of Hemoprotein Biomanufacturing in Yeast:From Upstream Engineering of Heme Synthesis to Downstream Purification of Human Hemoglobin

Authors: Frost, August Thinggaard

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/90f4acfb-2598-42d8-800d-78b35883fce1

Thesis Protein purification using magnetic adsorbent particles

Franzreb, M; Siemann-Herzberg, M.; Hobley, Timothy John et al. · 2006 · Technical University of Denmark (DTU) · DOI

Full title: Protein purification using magnetic adsorbent particles

Authors: Franzreb, M; Siemann-Herzberg, M.; Hobley, Timothy John; id_orcid 0000-0002-1355-6214; Thomas, O.R.T.

Year: 2006

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/9745b6e9-9fb8-4599-8cd1-a63238a46bc9

Thesis High-yield production of hydrophobins RodA and RodB from Aspergillus fumigatus in Pichia pastoris

Pedersen, Mona Højgaard; Borodina, Irina; Moresco, Jacob Lange et al. · 2011 · Technical University of Denmark (DTU) · DOI

Full title: High-yield production of hydrophobins RodA and RodB from Aspergillus fumigatus in Pichia pastoris

Authors: Pedersen, Mona Højgaard; Borodina, Irina; Moresco, Jacob Lange; Svendsen, Winnie Edith; id_orcid 0000-0002-9197-6505; Frisvad, Jens Christian; id_orcid 0000-0002-0573-4340; Søndergaard, Ib

Year: 2011

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a1ccacd9-c34f-4da7-8544-b884e71f635e

Thesis Selective flocculation and precipitation for the improvement of virus-like particle recovery from yeast homogenate

Tsoka, S.; Ciniawskyj, O. C.; Thomas, Owen R. T. et al. · 2000 · Technical University of Denmark (DTU) · DOI

Full title: Selective flocculation and precipitation for the improvement of virus-like particle recovery from yeast homogenate

Authors: Tsoka, S.; Ciniawskyj, O. C.; Thomas, Owen R. T.; Titchener-Hooker, N. J.; Hoare, M.

Year: 2000

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a358df35-e32d-4b36-9857-b51db0aceb9e

Thesis Design of smart liquid-liquid extraction columns for downstream separations of biopharmaceuticals using deep Q-learning algorithm

Hwangbo, Soonho; Öner, Merve; Sin, Gürkan et al. · 2019 · Technical University of Denmark (DTU) · DOI

Full title: Design of smart liquid-liquid extraction columns for downstream separations of biopharmaceuticals using deep Q-learning algorithm

Authors: Hwangbo, Soonho; Öner, Merve; Sin, Gürkan; id_orcid 0000-0003-0513-4502

Year: 2019

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/b5e8394c-399e-42d1-81bb-ee187c63061d

Thesis Superparamagnetic adsorbents for high-gradient magnetic fishing of lectins out of legume extracts

Heebøll-Nielsen, Anders; Dalkiær, M.; Hubbuch, Jürgen et al. · 2004 · Technical University of Denmark (DTU) · DOI

Full title: Superparamagnetic adsorbents for high-gradient magnetic fishing of lectins out of legume extracts

Authors: Heebøll-Nielsen, Anders; Dalkiær, M.; Hubbuch, Jürgen; Thomas, Owen R. T.

Year: 2004

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a0c4c724-8c93-4794-a65c-45c8d8dade1e

Thesis Advances in high-gradient magnetic fishing for bioprocessing

Goncalves Gomes, Claudia Sofia · 2006 · Technical University of Denmark (DTU) · DOI

Full title: Advances in high-gradient magnetic fishing for bioprocessing

Authors: Goncalves Gomes, Claudia Sofia

Year: 2006

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/972439b5-7d70-4b0b-803b-dc60b1ba9600

Thesis Characterization of recombinant high pI Barley α-Glucosidase

Næsted, Henrik; Svensson, Birte; id_orcid 0000-0002-2993-8196 · 2004 · Technical University of Denmark (DTU) · DOI

Full title: Characterization of recombinant high pI Barley α-Glucosidase

Authors: Næsted, Henrik; Svensson, Birte; id_orcid 0000-0002-2993-8196

Year: 2004

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/a66c147c-a1dd-4769-b052-21514e8a9d10

Thesis Superparamagnetic cation-exchange adsorbents for bioproduct recovery from crude process liquors by high-gradient magnetic fishing

Heebøll-Nielsen, Anders; Justesen, S.F.L; Hobley, Timothy John et al. · 2004 · Technical University of Denmark (DTU) · DOI

Full title: Superparamagnetic cation-exchange adsorbents for bioproduct recovery from crude process liquors by high-gradient magnetic fishing

Authors: Heebøll-Nielsen, Anders; Justesen, S.F.L; Hobley, Timothy John; id_orcid 0000-0002-1355-6214; Thomas, Owen R. T.

Year: 2004

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/aed9085e-a18f-4aed-83d6-3ff0bfecd787

Thesis Magnetic hydrophobic-charge induction adsorbents for the recovery of immunoglobulins from antiserum feedstocks by high-gradient magnetic fishing

Gomes, Cláudia Sofia Goncalves; Fashina, Adedayo; Fernández-Castané, Alfred et al. · 2018 · Technical University of Denmark (DTU) · DOI

Full title: Magnetic hydrophobic-charge induction adsorbents for the recovery of immunoglobulins from antiserum feedstocks by high-gradient magnetic fishing

Authors: Gomes, Cláudia Sofia Goncalves; Fashina, Adedayo; Fernández-Castané, Alfred; Overton, Timothy W; Hobley, Timothy John; id_orcid 0000-0002-1355-6214; Theodosiou, Eirini; Thomas, Owen R. T.

Year: 2018

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/bad1b658-578c-42d6-8964-1a38940109ba

Thesis A novel system for continuous protein refolding and on-line capture by expanded bed adsorption

Ferré, Henrik; Ruffet, E; Nielsen, L.L.B et al. · 2005 · Technical University of Denmark (DTU) · DOI

Full title: A novel system for continuous protein refolding and on-line capture by expanded bed adsorption

Authors: Ferré, Henrik; Ruffet, E; Nielsen, L.L.B; NIssen, M.H; Hobley, Timothy John; id_orcid 0000-0002-1355-6214; Thomas, O.R.T; Buus, Søren

Year: 2005

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c5894a70-b382-4a62-99f6-8b19b6dcdfc6

Thesis Early-Stage In Silico Flowsheet Analysis for a Monoclonal Antibody Platform

Kaiser, Johann; id_orcid 0000-0002-1383-6531; Babi, Deenesh K. et al. · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Early-Stage In Silico Flowsheet Analysis for a Monoclonal Antibody Platform

Authors: Kaiser, Johann; id_orcid 0000-0002-1383-6531; Babi, Deenesh K.; Pinelo, Manuel; id_orcid 0000-0002-3944-6144; Krühne, Ulrich; id_orcid 0000-0001-7774-7442

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/c3fbbf6b-2d0e-43ac-9387-8537778ebc8f

Thesis Secretory expression of functional barley limit dextrinase by Pichia pastoris using high cell-density fermentation

Vester-Christensen, Malene Bech; Abou Hachem, Maher; id_orcid 0000-0001-8250-1842 et al. · 2010 · Technical University of Denmark (DTU) · DOI

Full title: Secretory expression of functional barley limit dextrinase by Pichia pastoris using high cell-density fermentation

Authors: Vester-Christensen, Malene Bech; Abou Hachem, Maher; id_orcid 0000-0001-8250-1842; Næsted, Henrik; Svensson, Birte; id_orcid 0000-0002-2993-8196

Year: 2010

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ccbd5625-604f-4278-a789-7db7760eeec8

Thesis Novel multimodal cation-exchange membrane for the purification of a single-chain variable fragment from Pichia pastoris supernatant

Pham, Dan N.; id_orcid 0000-0002-7804-3882; Linova, Marina Y. et al. · 2024 · Technical University of Denmark (DTU) · DOI

Full title: Novel multimodal cation-exchange membrane for the purification of a single-chain variable fragment from Pichia pastoris supernatant

Year: 2024

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d389f2ef-aa9b-44aa-ab2a-6cc339b6945f

Thesis Optimizing protein-cell separation in submerged membrane bioreactor for clarification

Karki, Rebat; Skiadas, Ioannis V.; id_orcid 0000-0001-6183-4592 et al. · 2025 · Technical University of Denmark (DTU) · DOI

Full title: Optimizing protein-cell separation in submerged membrane bioreactor for clarification

Authors: Karki, Rebat; Skiadas, Ioannis V.; id_orcid 0000-0001-6183-4592; Woodley, John M.; id_orcid 0000-0002-7976-2483; Pinelo, Manuel; id_orcid 0000-0002-3944-6144

Year: 2025

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/d3e758c5-68ff-4a85-a40a-d984ecbacd53

Thesis High-level expression, secretion, and purification of the thermostable aqualysin I from Thermus aquaticus YT-1 in Pichia pastoris

Oledzka, G.; Dabrowski, Slawomir; Kur, J. · 2003 · Technical University of Denmark (DTU) · DOI

Full title: High-level expression, secretion, and purification of the thermostable aqualysin I from Thermus aquaticus YT-1 in Pichia pastoris

Authors: Oledzka, G.; Dabrowski, Slawomir; Kur, J.

Year: 2003

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e1399fb4-8a41-4cd2-95bf-a4e6d83777a4

Thesis Evaluation of SinglePass Tangential Flow Filtration

Kaiser, Johann; id_orcid 0000-0002-1383-6531 · 2022 · Technical University of Denmark (DTU) · DOI

Full title: Evaluation of SinglePass Tangential Flow Filtration

Authors: Kaiser, Johann; id_orcid 0000-0002-1383-6531

Year: 2022

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/e8b94114-f8d0-4eb6-91d0-605bba74497b

Thesis In Situ Magnetic Separation for Extracellular Protein Production

Kappler, T.; Cerff, Martin; Ottow, Kim Ekelund et al. · 2009 · Technical University of Denmark (DTU) · DOI

Full title: In Situ Magnetic Separation for Extracellular Protein Production

Authors: Kappler, T.; Cerff, Martin; Ottow, Kim Ekelund; Hobley, Timothy John; id_orcid 0000-0002-1355-6214; Posten, C.

Year: 2009

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/faecf11d-7fb0-4ebb-ad22-ebb03af958a3

Thesis BIOMOLECULES EXTRACTED BY ATPS: PRACTICAL EXAMPLES

Dutra-Molino, J. V.; Feitosa, V. Araujo; Lencastre-Novaes, L. C. de et al. · 2015 · Universidade Estadual Paulista (UNESP) · DOI

Full title: BIOMOLECULES EXTRACTED BY ATPS: PRACTICAL EXAMPLES

Authors: Dutra-Molino, J. V.; Feitosa, V. Araujo; Lencastre-Novaes, L. C. de; Santos-Ebinuma, V. de Carvalho [UNESP]; Lopes, A. Moreni; Jozala, A. Faustino; Viana Marques, D. de Araujo; Malpiedi, L. Pellegrini; Pessoa Junior, A.

Year: 2015

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://redalyc.org/articulo.oa?id=62031508001

Thesis Liquid–liquid extraction of biopharmaceuticals from fermented broth: trends and future prospects

dos Santos, Nathalia Vieira [UNESP]; de Carvalho Santos-Ebinuma, Valéria [UNESP]; Pessoa Junior, Adalberto et al. · 2018 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Liquid–liquid extraction of biopharmaceuticals from fermented broth: trends and future prospects

Authors: dos Santos, Nathalia Vieira [UNESP]; de Carvalho Santos-Ebinuma, Valéria [UNESP]; Pessoa Junior, Adalberto; Pereira, Jorge Fernando Brandão [UNESP]

Year: 2018

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1002/jctb.5476

Thesis Biomoléculas extraídas por sbas: Ejemplos prácticos

Dutra-Molino, J. V.; Araujo Feitosa, V.; de Lencastre-Novaes, L. C. et al. · 2018 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Biomoléculas extraídas por sbas: Ejemplos prácticos

Authors: Dutra-Molino, J. V.; Araujo Feitosa, V.; de Lencastre-Novaes, L. C.; de Carvalho Santos-Ebinuma, V. [UNESP]; Moreni Lopes, A.; Faustino Jozala, A.; de Aráujo Viana Marques, D.; Pellegrini Malpiedi, L.; Pessoa, A.

Year: 2018

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://hdl.handle.net/11449/167637

Thesis Fractionation of whey proteins with high-capacity superparamagnetic ion-exchangers

Heebøll-Nielsen, Anders; Justesen, S.F.L.; Thomas, Owen R. T. · 2004 · Technical University of Denmark (DTU) · DOI

Full title: Fractionation of whey proteins with high-capacity superparamagnetic ion-exchangers

Authors: Heebøll-Nielsen, Anders; Justesen, S.F.L.; Thomas, Owen R. T.

Year: 2004

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ee23a7a2-cb83-49bf-bb25-7f515188c3d3

Thesis Purification of rabies virus glycoprotein produced in Drosophila melanogaster S2 cells: An efficient immunoaffinity method

Pilatti, Livia; Mancini Astray, Renato; Rocca, Mayra Pereira [UNESP] et al. · 2020 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Purification of rabies virus glycoprotein produced in Drosophila melanogaster S2 cells: An efficient immunoaffinity method

Authors: Pilatti, Livia; Mancini Astray, Renato; Rocca, Mayra Pereira [UNESP]; Barbosa, Flavia Ferreira; Jorge, Soraia Attie Calil; Butler, Michael; de Fátima Pires Augusto, Elisabeth

Year: 2020

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1002/btpr.3046

Thesis Aqueous Biphasic Systems Composed of Cholinium Chloride and Polymers as Effective Platforms for the Purification of Recombinant Green Fluorescent Protein

Dos Santos, Nathalia V. [UNESP]; Martins, Margarida; Santos-Ebinuma, Valéria C. [UNESP] et al. · 2018 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Aqueous Biphasic Systems Composed of Cholinium Chloride and Polymers as Effective Platforms for the Purification of Recombinant Green Fluorescent Protein

Authors: Dos Santos, Nathalia V. [UNESP]; Martins, Margarida; Santos-Ebinuma, Valéria C. [UNESP]; Ventura, Sónia P. M.; Coutinho, Joaìo A. P.; Valentini, Sandro R. [UNESP]; Pereira, Jorge F. B. [UNESP]

Year: 2018

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1021/acssuschemeng.8b01730

Thesis Effect of electrolytes as adjuvants in GFP and LPS partitioning on aqueous two-phase systems: 2. Nonionic micellar systems

Teixeira-Pinto, Renata Garcia Rodrigues; Molino, João Vitor Dutra; Santos-Ebinuma, Valéria Carvalho [UNESP] et al. · 2019 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Effect of electrolytes as adjuvants in GFP and LPS partitioning on aqueous two-phase systems: 2. Nonionic micellar systems

Authors: Teixeira-Pinto, Renata Garcia Rodrigues; Molino, João Vitor Dutra; Santos-Ebinuma, Valéria Carvalho [UNESP]; Pessoa, Adalberto; Valentini, Sandro Roberto; Pereira, Jorge Fernando Brandão [UNESP]; Lopes, André Moreni [UNESP]

Year: 2019

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1016/j.seppur.2018.07.078

Thesis Biomolecules extracted by ATPs: practical examples

Molino, João Vitor Dutra; Feitosa, Valker A.; Novaes, Leticia Celia de Lencastre et al. · 2016 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Biomolecules extracted by ATPs: practical examples

Authors: Molino, João Vitor Dutra; Feitosa, Valker A.; Novaes, Leticia Celia de Lencastre; Ebinuma, Valéria de Carvalho Santos [UNESP]; Lopes, André Moreni; Jozala, Angela Faustino; Marques, Daniela de Araujo Viana; Malpiedi, L. Pellegrine; Pessoa Júnior, Adalberto

Year: 2016

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://www.redalyc.org/articulo.oa?id=62031508001

Thesis Purification of green fluorescent protein using fast centrifugal partition chromatography

Soares, Bruna P.; Santos, João H.P.M.; Martins, Margarida et al. · 2021 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Purification of green fluorescent protein using fast centrifugal partition chromatography

Authors: Soares, Bruna P.; Santos, João H.P.M.; Martins, Margarida; Almeida, Mafalda R.; Santos, Nathalia V. [UNESP]; Freire, Mara G.; Santos-Ebinuma, Valéria C. [UNESP]; Coutinho, João A.P.; Pereira, Jorge F.B. [UNESP]; Ventura, Sónia P.M.

Year: 2021

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1016/j.seppur.2020.117648

Thesis Aqueous two-phase systems: Towards novel and more disruptive applications

Pereira, Jorge F.B. [UNESP]; Freire, Mara G.; Coutinho, João A.P. · 2020 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Aqueous two-phase systems: Towards novel and more disruptive applications

Authors: Pereira, Jorge F.B. [UNESP]; Freire, Mara G.; Coutinho, João A.P.

Year: 2020

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1016/j.fluid.2019.112341

Thesis Recombinant laccase biosynthesis for efficient polydopamine coating

Magalhães, Flávia F.; Neves, Márcia C.; Pedro, Augusto Q. et al. · 2025 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Recombinant laccase biosynthesis for efficient polydopamine coating

Authors: Magalhães, Flávia F.; Neves, Márcia C.; Pedro, Augusto Q.; Freire, Mara G.; Santos-Ebinuma, Valéria C. [UNESP]; Tavares, Ana P.M.

Year: 2025

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1016/j.bej.2024.109483

Thesis Advances in separation by ionic strength: Association of chromatography and ionic liquids or deep eutectic solvents for the purification of microalgae-based products

Veríssimo, Nathalia Vieira Porphirio [UNESP]; Mussagy, Cassamo Usemane; de Lima, Júlio Gabriel Oliveira [UNESP] et al. · 2025 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Advances in separation by ionic strength: Association of chromatography and ionic liquids or deep eutectic solvents for the purification of microalgae-based products

Authors: Veríssimo, Nathalia Vieira Porphirio [UNESP]; Mussagy, Cassamo Usemane; de Lima, Júlio Gabriel Oliveira [UNESP]; Santos-Ebinuma, Valéria de Carvalho [UNESP]

Year: 2025

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1016/B978-0-443-14059-4.00027-1

Thesis Recombinant laccase biosynthesis for efficient polydopamine coating

Magalhães, Flávia F.; Neves, Márcia C.; Pedro, Augusto Q. et al. · 2025 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Recombinant laccase biosynthesis for efficient polydopamine coating

Authors: Magalhães, Flávia F.; Neves, Márcia C.; Pedro, Augusto Q.; Freire, Mara G.; Santos-Ebinuma, Valéria C. [UNESP]; Tavares, Ana P.M.

Year: 2025

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1016/j.bej.2024.109483

Thesis Conditions affecting production of functional muscle recombinant alpha-tropomyosin in Saccharomyces cerevisiae

Alegria, M. C.; Lavarda, SCS; Lataro, R. C. et al. · 2014 · Universidade Estadual Paulista (UNESP) · DOI

Full title: Conditions affecting production of functional muscle recombinant alpha-tropomyosin in Saccharomyces cerevisiae

Authors: Alegria, M. C.; Lavarda, SCS; Lataro, R. C.; Hilario, E.; Ferro, J. A.; Bertolini, Maria Celia [UNESP]

Year: 2014

Venue: Universidade Estadual Paulista (UNESP)

DOI: http://dx.doi.org/10.1016/S1046-5928(03)00094-9

Thesis Preparation of Highly Purified Hemoglobin by Affinity Elution

Xue, Hong; Zheng, Hui; Wu, Xiangfu · 1998 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Preparation of Highly Purified Hemoglobin by Affinity Elution

Authors: Xue, Hong; Zheng, Hui; Wu, Xiangfu

Year: 1998

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-24996

Thesis Affinity-tagged green fluorescent protein (GFP) extraction from a clarified E-coli cell lysate using a two-phase aqueous micellar system

Mazzola, PG; Lam, Henry H N; Kavoosi, M. et al. · 2006 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Affinity-tagged green fluorescent protein (GFP) extraction from a clarified E-coli cell lysate using a two-phase aqueous micellar system

Authors: Mazzola, PG; Lam, Henry H N; Kavoosi, M.; Haynes, CA; Pessoa, A.; Penna, TCV; Wang, DIC; Blankschtein, D.

Year: 2006

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-50612

Thesis An Airlift Crystallizer for Protein Crystallization

Mathew Thomas, Kiran CBME; Lakerveld, Richard · 2019 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: An Airlift Crystallizer for Protein Crystallization

Authors: Mathew Thomas, Kiran CBME; Lakerveld, Richard

Year: 2019

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-100712

Thesis In vivo and in vitro cleavages of inteins through modifications of terminal regions and revisions of environmental factors

Wang, Hao · 2019 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: In vivo and in vitro cleavages of inteins through modifications of terminal regions and revisions of environmental factors

Authors: Wang, Hao

Year: 2019

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-100066

Thesis Purification of Authentic Human Basic Fibroblast Growth Factor Expressed in Both the Cytoplasm and Culture Medium of Escherichia coli

Thiyagarajan, Sivakumar; Lai, Cheuk Yin; Lam, chui-chi et al. · 2018 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Purification of Authentic Human Basic Fibroblast Growth Factor Expressed in Both the Cytoplasm and Culture Medium of Escherichia coli

Authors: Thiyagarajan, Sivakumar; Lai, Cheuk Yin; Lam, chui-chi; Hu, Xiuhua; Wang, Hao; Ng, Ka Lun; Wong, Wan Keung

Year: 2018

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-90036

Thesis Human epidermal growth factor excreted by recombinant Escherichia coli K-12 has the correct N-terminus and is fully bioactive

Huang, RC; Lam, E.; Chen, YH et al. · 1999 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Human epidermal growth factor excreted by recombinant Escherichia coli K-12 has the correct N-terminus and is fully bioactive

Authors: Huang, RC; Lam, E.; Chen, YH; Hackett, J.; Lam, TL; Liu, D.; Ma, MC; Siu, KL; Sivakesava, S.; Xu, ZN; Wong, Raymond S C; Wong, Wan Keung

Year: 1999

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-2147

Thesis An efficient intein approach to improve recombinant production of basic fibroblast growth factor in escherichia coli

Thiyagarajan, Sivakumar · 2018 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: An efficient intein approach to improve recombinant production of basic fibroblast growth factor in escherichia coli

Authors: Thiyagarajan, Sivakumar

Year: 2018

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-96197

Thesis Affinity-enhanced protein partitioning in decyl beta-D-glucopyranoside two-phase aqueous micellar systems

Lam, Henry H N; Kavoosi, M.; Haynes, CA et al. · 2005 · Hong Kong University of Science and Technology (HKUST) · DOI

Full title: Affinity-enhanced protein partitioning in decyl beta-D-glucopyranoside two-phase aqueous micellar systems

Authors: Lam, Henry H N; Kavoosi, M.; Haynes, CA; Wang, DIC; Blankschtein, D.

Year: 2005

Venue: Hong Kong University of Science and Technology (HKUST)

DOI: http://repository.hkust.edu.hk/ir/Record/1783.1-52238

Thesis Hybrid Particle-Nonwoven Membrane Materials for Bioseparations

Herigstad, Matthew Omon · 2010 · North Carolina State University · DOI

Full title: Hybrid Particle-Nonwoven Membrane Materials for Bioseparations

Authors: Herigstad, Matthew Omon

Year: 2010

Venue: North Carolina State University

DOI: http://www.lib.ncsu.edu/resolver/1840.16/5412

Thesis Application of Raman spectroscopy to dynamic binding capacity analysis

Beattie, James W; Rowland-Jones, Ruth C; Farys, Monika et al. · 2024 · Imperial College London · DOI

Full title: Application of Raman spectroscopy to dynamic binding capacity analysis

Authors: Beattie, James W; Rowland-Jones, Ruth C; Farys, Monika; Bettany, Hamish; Hilton, David; Kazarian, Sergei G; Byrne, Bernadette

Year: 2024

Venue: Imperial College London

DOI: https://www.ncbi.nlm.nih.gov/pubmed/37908083

Thesis Cascaded de novo biosynthesis of lacto-proteins from CO2 by engineered Pichia pastoris

Lv, Xueqin; Cui, Shixiu; Chen, Jie et al. · 2024 · Imperial College London · DOI

Full title: Cascaded de novo biosynthesis of lacto-proteins from CO2 by engineered Pichia pastoris

Authors: Lv, Xueqin; Cui, Shixiu; Chen, Jie; Wang, Lingrui; Liu, Yanfeng; Li, Jianghua; Du, Guocheng; Liu, Xiaohao; Chen, Jian; Ledesma-Amaro, Rodrigo; Liu, Long

Year: 2024

Venue: Imperial College London

DOI: https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:001020551500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb

Thesis Monitoring of biotherapeutic purification by vibrational spectroscopy

Beattie, James · 2025 · Imperial College London · DOI

Full title: Monitoring of biotherapeutic purification by vibrational spectroscopy

Authors: Beattie, James

Year: 2025

Venue: Imperial College London

DOI: https://hdl.handle.net/10044/1/123044

Thesis A model-based approach towards accelerated process development: a case study on chromatography

Sachio, Steven; Kontoravdi, Cleo; Papathanasiou, Maria M · 2024 · Imperial College London · DOI

Full title: A model-based approach towards accelerated process development: a case study on chromatography

Authors: Sachio, Steven; Kontoravdi, Cleo; Papathanasiou, Maria M

Year: 2024

Venue: Imperial College London

DOI: https://www.sciencedirect.com/science/article/pii/S0263876223005166

Thesis The second virial coefficient as a predictor of protein aggregation propensity: a self-interaction chromatography study

Williams, DR; Quigley, A · 2015 · Imperial College London · DOI

Full title: The second virial coefficient as a predictor of protein aggregation propensity: a self-interaction chromatography study

Authors: Williams, DR; Quigley, A

Year: 2015

Venue: Imperial College London

DOI: https://www.sciencedirect.com/science/article/pii/S0939641115003288

Thesis Cleaning-in-place for immunoaffinity resin monitored by in situ ATR-FTIR spectroscopy

Byrne, B; Kazarian, SG; Boulet-Audet, M · 2015 · Imperial College London · DOI

Full title: Cleaning-in-place for immunoaffinity resin monitored by in situ ATR-FTIR spectroscopy

Authors: Byrne, B; Kazarian, SG; Boulet-Audet, M

Year: 2015

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/24035

Thesis Liquid PTVA: A faster and cheaper alternative for generating multi-copy clones in Pichia pastoris

Aw, R; Polizzi, KM · 2016 · Imperial College London · DOI

Full title: Liquid PTVA: A faster and cheaper alternative for generating multi-copy clones in Pichia pastoris

Authors: Aw, R; Polizzi, KM

Year: 2016

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/29028

Thesis In-column ATR-FTIR spectroscopy to monitor affinity chromatography purification of monoclonal antibodies

Boulet-Audet, M; Kazarian, SG; Byrne, B · 2016 · Imperial College London · DOI

Full title: In-column ATR-FTIR spectroscopy to monitor affinity chromatography purification of monoclonal antibodies

Authors: Boulet-Audet, M; Kazarian, SG; Byrne, B

Year: 2016

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/34378

Thesis Mild hypothermic culture conditions impact residual host cell protein composition post-protein a chromatography

Goey, CH; Bell, David; Kontoravdi, K · 2018 · Imperial College London · DOI

Full title: Mild hypothermic culture conditions impact residual host cell protein composition post-protein a chromatography

Authors: Goey, CH; Bell, David; Kontoravdi, K

Year: 2018

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/63191

Thesis Protein separation using surfactant precipitation

Cheng, Shu Ian; Cheng, Shu Ian · 2012 · Imperial College London · DOI

Full title: Protein separation using surfactant precipitation

Authors: Cheng, Shu Ian; Cheng, Shu Ian

Year: 2012

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/9282

Thesis Selective crystallisation facilitated by nanonucleants for downstream bioseparation of a protein mixture

Li, Xiaoyu · 2022 · Imperial College London · DOI

Full title: Selective crystallisation facilitated by nanonucleants for downstream bioseparation of a protein mixture

Authors: Li, Xiaoyu

Year: 2022

Venue: Imperial College London

DOI: http://hdl.handle.net/10044/1/99009

Thesis High‐Throughput Optimization of Recombinant Protein Production in Microfluidic Gel Beads

Napiorkowska, Marta; Pestalozzi, Luzius; Panke, Sven et al. · 2021 · ETH Zurich (Swiss Federal Institute of Technology in Zurich) · DOI

Full title: High‐Throughput Optimization of Recombinant Protein Production in Microfluidic Gel Beads

Authors: Napiorkowska, Marta; Pestalozzi, Luzius; Panke, Sven; id_orcid0000-0002-9368-539X; Held, Martin; Schmitt, Steven

Year: 2021

Venue: ETH Zurich (Swiss Federal Institute of Technology in Zurich)

DOI: http://hdl.handle.net/20.500.11850/458699

Thesis Producció recombinant de la gonadotrofina coriònica equina amb el llevat Pichia pastoris

Ubach Font, Anna · 2011 · Universitat Autònoma de Barcelona (TDX) · DOI

Full title: Producció recombinant de la gonadotrofina coriònica equina amb el llevat Pichia pastoris

Authors: Ubach Font, Anna

Year: 2011

Venue: Universitat Autònoma de Barcelona (TDX)

DOI: http://www.tdx.cat/TDX-0414110-153424

Thesis Large-Scale Purification and Characterization of Recombinant Receptor-Binding Domain (RBD) of SARS-CoV-2 Spike Protein Expressed in Yeast

Nagar, Gaurav; Jain, Siddharth; Rajurkar, Meghraj et al. · 2023 · Massachusetts Institute of Technology (MIT) · DOI

Full title: Large-Scale Purification and Characterization of Recombinant Receptor-Binding Domain (RBD) of SARS-CoV-2 Spike Protein Expressed in Yeast

Authors: Nagar, Gaurav; Jain, Siddharth; Rajurkar, Meghraj; Lothe, Rakesh; Rao, Harish; Majumdar, Sourav; Gautam, Manish; Rodriguez-Aponte, Sergio A.; Crowell, Laura E.; Love, J. Christopher; Dandekar, Prajakta; Puranik, Amita; Gairola, Sunil; Shaligram, Umesh; Jain, Ratnesh

Year: 2023

Venue: Massachusetts Institute of Technology (MIT)

DOI: https://hdl.handle.net/1721.1/152537

Thesis Impact of Nanoparticle Aggregation on Protein Recovery through a Pentadentate Chelate Ligand on Magnetic Carriers

Fraga García, P.; Freiherr von Roman, M.; Reinlein, S. et al. · 2014 · Technical University of Munich (TUM) · DOI

Full title: Impact of Nanoparticle Aggregation on Protein Recovery through a Pentadentate Chelate Ligand on Magnetic Carriers

Authors: Fraga García, P.; Freiherr von Roman, M.; Reinlein, S.; Wolf, M.; Berensmeier, S.

Year: 2014

Venue: Technical University of Munich (TUM)

DOI: https://mediatum.ub.tum.de/1230644

Thesis Pseudo-affinity capture of K. phaffii host cell proteins in flow-through mode: purification of protein therapeutics and proteomic study

Sripada, Sobhana A.; Elhanafi, Driss; Collins, Leonard B. et al. · 2023 · Technical University of Denmark (DTU) · DOI

Full title: Pseudo-affinity capture of K. phaffii host cell proteins in flow-through mode: purification of protein therapeutics and proteomic study

Year: 2023

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/7581505e-4aa5-44f4-8a87-2f0ddf89bb09

Thesis Lactoferrin: similarity to diamine oxidase and purification by aminohexyl affinity chromatography

Houen, G.; Høgdall, Estrid; Barkholt, Helle Vibeke et al. · 1996 · Technical University of Denmark (DTU) · DOI

Full title: Lactoferrin: similarity to diamine oxidase and purification by aminohexyl affinity chromatography

Authors: Houen, G.; Høgdall, Estrid; Barkholt, Helle Vibeke; Nørskov, L.

Year: 1996

Venue: Technical University of Denmark (DTU)

DOI: https://orbit.dtu.dk/en/publications/ba1d4fcc-ec3f-4c72-9223-99c3eb294302

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2. Data Extraction

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Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells.

Plouët, Jean; Ling, Xuefeng B.; Gospodarowicz, Denis · 1989

Full title: Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells.

Authors: Plouët, Jean; Ling, Xuefeng B.; Gospodarowicz, Denis

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Novel method for production and purification of untagged pneumococcal surface protein A from clade 1.

da Costa Rodrigues, Tasson; Zorzete, Patricia; Miyaji, Eliane Namie et al. · 2024

Full title: Novel method for production and purification of untagged pneumococcal surface protein A from clade 1.

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Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain-based vaccine candidate, RBD219-N1C1.

Lee, Jungsoon; Liu, Zhuyun; Chen, Wen-Hsiang et al. · 2021

Full title: Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain-based vaccine candidate, RBD219-N1C1.

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Foam fractionation Tags (F-Tags) enabling surfactant-free, activity-preserving recovery of enzymes.

Krause, Thomas; Keshavarzi, Behnam; Heitkam, Sascha et al. · 2024

Full title: Foam fractionation Tags (F-Tags) enabling surfactant-free, activity-preserving recovery of enzymes.

Authors: Krause, Thomas; Keshavarzi, Behnam; Heitkam, Sascha; Ansorge-Schumacher, Marion B

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Comparison of downstream processing methods in purification of highly active laccase.

Antecka, Anna; Blatkiewicz, Michał; Boruta, Tomasz et al. · 2019

Full title: Comparison of downstream processing methods in purification of highly active laccase.

Authors: Antecka, Anna; Blatkiewicz, Michał; Boruta, Tomasz; Górak, Andrzej; Ledakowicz, Stanisław

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Screening and identification of genetic loci involved in producing more/denser inclusion bodies in Escherichia coli.

Pandey, Neeraj; Sachan, Annapurna; Chen, Qi et al. · 2013

Full title: Screening and identification of genetic loci involved in producing more/denser inclusion bodies in Escherichia coli.

Authors: Pandey, Neeraj; Sachan, Annapurna; Chen, Qi; Ruebling-Jass, Kristin; Bhalla, Ritu; Panguluri, Kiran Kumar; Rouviere, Pierre E; Cheng, Qiong

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Recombinant expression of Barnase in Escherichia coli and its application in plasmid purification.

Shankar, Ram; Schäffer, Nina; Schmeer, Marco et al. · 2021

Full title: Recombinant expression of Barnase in Escherichia coli and its application in plasmid purification.

Authors: Shankar, Ram; Schäffer, Nina; Schmeer, Marco; Risse, Joe Max; Friehs, Karl; Schleef, Martin

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Streamlined purification of ADDomer nanoparticles for scalable biomanufacturing.

Arinto-Garcia, Raquel; Paiva, Cláudia S; Dilla, Emerson Bryan et al. · 2025

Full title: Streamlined purification of ADDomer nanoparticles for scalable biomanufacturing.

DOI: https://doi.org/10.1186/s13036-025-00558-0

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Economic purification of recombinant uricase by artificial oil bodies.

Saadat, Fatemeh; Macheroux, Peter; Alizadeh, Houshang et al. · 2022

Full title: Economic purification of recombinant uricase by artificial oil bodies.

Authors: Saadat, Fatemeh; Macheroux, Peter; Alizadeh, Houshang; Razavi, Seyed Hadi

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Cost-effective downstream processing of recombinantly produced pexiganan peptide and its antimicrobial activity.

Sun, Baode; Wibowo, David; Middelberg, Anton P J et al. · 2018

Full title: Cost-effective downstream processing of recombinantly produced pexiganan peptide and its antimicrobial activity.

Authors: Sun, Baode; Wibowo, David; Middelberg, Anton P J; Zhao, Chun-Xia

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Evaluation of novel large cut-off ultrafiltration membranes for adenovirus serotype 5 (Ad5) concentration.

Nestola, Piergiuseppe; Martins, Duarte L; Peixoto, Cristina et al. · 2014

Full title: Evaluation of novel large cut-off ultrafiltration membranes for adenovirus serotype 5 (Ad5) concentration.

Authors: Nestola, Piergiuseppe; Martins, Duarte L; Peixoto, Cristina; Roederstein, Susanne; Schleuss, Tobias; Alves, Paula M; Mota, José P B; Carrondo, Manuel J T

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Towards protein crystallization as a process step in downstream processing of therapeutic antibodies: screening and optimization at microbatch scale.

Zang, Yuguo; Kammerer, Bernd; Eisenkolb, Maike et al. · 2011

Full title: Towards protein crystallization as a process step in downstream processing of therapeutic antibodies: screening and optimization at microbatch scale.

Authors: Zang, Yuguo; Kammerer, Bernd; Eisenkolb, Maike; Lohr, Katrin; Kiefer, Hans

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Integrated Process for Capture and Purification of Virus-Like Particles: Enhancing Process Performance by Cross-Flow Filtration.

Hillebrandt, Nils; Vormittag, Philipp; Bluthardt, Nicolai et al. · 2020

Full title: Integrated Process for Capture and Purification of Virus-Like Particles: Enhancing Process Performance by Cross-Flow Filtration.

Authors: Hillebrandt, Nils; Vormittag, Philipp; Bluthardt, Nicolai; Dietrich, Annabelle; Hubbuch, Jürgen

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A Generic Procedure for the Isolation of pH- and Magnesium-Responsive Chicken scFvs for Downstream Purification of Human Antibodies.

Hinz, Steffen C; Elter, Adrian; Rammo, Oliver et al. · 2020

Full title: A Generic Procedure for the Isolation of pH- and Magnesium-Responsive Chicken scFvs for Downstream Purification of Human Antibodies.

Authors: Hinz, Steffen C; Elter, Adrian; Rammo, Oliver; Schwämmle, Achim; Ali, Ataurehman; Zielonka, Stefan; Herget, Thomas; Kolmar, Harald

DOI: https://doi.org/10.3389/fbioe.2020.00688

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Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcγ Receptors: Implications for Measuring Fc Dependent Antibody Functions.

Lopez, Ester; Scott, Nichollas E; Wines, Bruce D et al. · 2019

Full title: Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcγ Receptors: Implications for Measuring Fc Dependent Antibody Functions.

Authors: Lopez, Ester; Scott, Nichollas E; Wines, Bruce D; Hogarth, P Mark; Wheatley, Adam K; Kent, Stephen J; Chung, Amy W

DOI: https://doi.org/10.3389/fimmu.2019.02415

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Magnetic Separation in Bioprocessing Beyond the Analytical Scale: From Biotechnology to the Food Industry.

Schwaminger, Sebastian P; Fraga-García, Paula; Eigenfeld, Marco et al. · 2019

Full title: Magnetic Separation in Bioprocessing Beyond the Analytical Scale: From Biotechnology to the Food Industry.

Authors: Schwaminger, Sebastian P; Fraga-García, Paula; Eigenfeld, Marco; Becker, Thomas M; Berensmeier, Sonja

DOI: https://doi.org/10.3389/fbioe.2019.00233

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Optimized Blanching Reduces the Host Cell Protein Content and Substantially Enhances the Recovery and Stability of Two Plant-Derived Malaria Vaccine Candidates.

Menzel, Stephan; Holland, Tanja; Boes, Alexander et al. · 2016

Full title: Optimized Blanching Reduces the Host Cell Protein Content and Substantially Enhances the Recovery and Stability of Two Plant-Derived Malaria Vaccine Candidates.

Authors: Menzel, Stephan; Holland, Tanja; Boes, Alexander; Spiegel, Holger; Bolzenius, Johanna; Fischer, Rainer; Buyel, Johannes F

DOI: https://doi.org/10.3389/fpls.2016.00159

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Extraction and purification of phycobiliproteins from algae and their applications.

Kovaleski, Gabriela; Kholany, Mariam; Dias, Lília M S et al. · 2022

Full title: Extraction and purification of phycobiliproteins from algae and their applications.

Authors: Kovaleski, Gabriela; Kholany, Mariam; Dias, Lília M S; Correia, Sandra F H; Ferreira, Rute A S; Coutinho, João A P; Ventura, Sónia P M

DOI: https://doi.org/10.3389/fchem.2022.1065355

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Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation.

Almeida, Catarina; Pedro, Augusto Q; Tavares, Ana P M et al. · 2023

Full title: Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation.

Authors: Almeida, Catarina; Pedro, Augusto Q; Tavares, Ana P M; Neves, Márcia C; Freire, Mara G

DOI: https://doi.org/10.3389/fbioe.2023.1037436

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Integrated Clarification and Purification of Monoclonal Antibodies by Membrane Based Separation of Aqueous Two-Phase Systems.

Kruse, Thomas; Schmidt, Axel; Kampmann, Markus et al. · 2019

Full title: Integrated Clarification and Purification of Monoclonal Antibodies by Membrane Based Separation of Aqueous Two-Phase Systems.

Authors: Kruse, Thomas; Schmidt, Axel; Kampmann, Markus; Strube, Jochen

DOI: https://doi.org/10.3390/antib8030040

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Affinity Membranes and Monoliths for Protein Purification.

Lalli, Eleonora; Silva, Jouciane S; Boi, Cristiana et al. · 2019

Full title: Affinity Membranes and Monoliths for Protein Purification.

Authors: Lalli, Eleonora; Silva, Jouciane S; Boi, Cristiana; Sarti, Giulio C

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In-Line Monitoring of Downstream Purification Processes for VSV Based SARS-CoV-2 Vaccine Using a Novel Technique.

Makovitzki, Arik; Jayson, Avital; Oren, Ziv et al. · 2021

Full title: In-Line Monitoring of Downstream Purification Processes for VSV Based SARS-CoV-2 Vaccine Using a Novel Technique.

DOI: https://doi.org/10.3390/biotech10040025

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Grünberg, Mario; Kuchemüller, Kim B; Töppner, Katrin et al. · 2022

Full title: Scalable, Robust and Highly Productive Novel Convecdiff Membrane Platform for mAb Capture.

Authors: Grünberg, Mario; Kuchemüller, Kim B; Töppner, Katrin; Busse, Ricarda A

DOI: https://doi.org/10.3390/membranes12070677

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Full title: Applying UHPLC-HRAM MS/MS Method to Assess Host Cell Protein Clearance during the Purification Process Development of Therapeutic mAbs.

Authors: Kiyonami, Reiko; Melani, Rafael; Chen, Ying; Leon, A I De; Du, Min

DOI: https://doi.org/10.3390/ijms25179687

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Optimization of Tangential Flow Filtration for High-Yield, Scalable Downstream Processing of Adeno-Associated Virus.

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Full title: Optimization of Tangential Flow Filtration for High-Yield, Scalable Downstream Processing of Adeno-Associated Virus.

Authors: Cardoso, Sara; Bollmann, Franziska; Tappe, Alexander

DOI: https://doi.org/10.3390/membranes16020073

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Full title: Absolute Quantification of Hepatitis B Core Antigen (HBcAg) Virus-like Particles and Bound Nucleic Acids.

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DOI: https://doi.org/10.3390/v16010013

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Full title: Removal of Aggregates During Bispecific Antibody Purification Using Hydrophobic Interaction Chromatography.

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DOI: https://doi.org/10.3390/membranes15100299

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Purification Process of a Recombinant Human Follicle Stimulating Hormone Biosimilar (Primapur®) to Yield a Pharmaceutical Product with High Batch-to-Batch Consistency.

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Full title: Purification Process of a Recombinant Human Follicle Stimulating Hormone Biosimilar (Primapur®) to Yield a Pharmaceutical Product with High Batch-to-Batch Consistency.

Authors: Sinegubova, Maria; Vorobiev, Ivan; Klishin, Anatoly; Eremin, Dmitry; Orlova, Nadezhda; Orlova, Natalya; Polzikov, Mikhail

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Full title: Evaluation of the Robustness Verification of Downstream Production Process for Inactivated SARS-CoV-2 Vaccine and Different Chromatography Medium Purification Effects.

Authors: Pang, Jia-Hui; Guo, Chang-Fu; Hao, Peng-Liang; Meng, Sheng-Li; Guo, Jing; Zhang, Dou; Ji, Ya-Qi; Ming, Ping-Gang

DOI: https://doi.org/10.3390/vaccines12010056

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Membrane Chromatography-Based Downstream Processing for Cell-Culture Produced Influenza Vaccines.

Yang, Zeyu; Xu, Xingge; Silva, Cristina A T et al. · 2022

Full title: Membrane Chromatography-Based Downstream Processing for Cell-Culture Produced Influenza Vaccines.

DOI: https://doi.org/10.3390/vaccines10081310

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Exploitation of Ultrasound Technique for Enhancement of Microbial Metabolites Production.

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Full title: Exploitation of Ultrasound Technique for Enhancement of Microbial Metabolites Production.

Authors: Behzadnia, Asma; Moosavi-Nasab, Marzieh; Ojha, Shikha; Tiwari, Brijesh K

DOI: https://doi.org/10.3390/molecules25225473

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Satisfying QTPP of Erythropoietin Biosimilar by QbD through DoE-Derived Downstream Process Engineering.

Nag, Kakon; Sarker, Enamul Haq; Kumar, Samir et al. · 2023

Full title: Satisfying QTPP of Erythropoietin Biosimilar by QbD through DoE-Derived Downstream Process Engineering.

DOI: https://doi.org/10.3390/pharmaceutics15082087

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Determining buffer conditions for downstream processing of VLP-based recombinant hepatitis B surface antigen using multimodal resins in bind-elute and flow-through purification modes.

Goodarzi, Maryam Moazami; Jalalirad, Reza; Doroud, Delaram et al. · 2023

Full title: Determining buffer conditions for downstream processing of VLP-based recombinant hepatitis B surface antigen using multimodal resins in bind-elute and flow-through purification modes.

Authors: Goodarzi, Maryam Moazami; Jalalirad, Reza; Doroud, Delaram; Hozouri, Hamidreza; Aghasadeghi, Mohammadreza; Paryan, Mahdi

DOI: https://doi.org/10.1038/s41598-023-37614-y

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Toward microfluidic continuous-flow and intelligent downstream processing of biopharmaceuticals.

Sharma, Vikas; Mottafegh, Amirreza; Joo, Jeong-Un et al. · 2024

Full title: Toward microfluidic continuous-flow and intelligent downstream processing of biopharmaceuticals.

Authors: Sharma, Vikas; Mottafegh, Amirreza; Joo, Jeong-Un; Kang, Ji-Ho; Wang, Lei; Kim, Dong-Pyo

DOI: https://doi.org/10.1039/d3lc01097j

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Quality assessment and optimization of purified protein samples: why and how?

Raynal, Bertrand; Lenormand, Pascal; Baron, Bruno et al. · 2014

Full title: Quality assessment and optimization of purified protein samples: why and how?

Authors: Raynal, Bertrand; Lenormand, Pascal; Baron, Bruno; Hoos, Sylviane; England, Patrick

DOI: https://doi.org/10.1186/s12934-014-0180-6

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The lyophilized chloroplasts store synthetic DARPin G3 as bioactive encapsulated organelles.

Ehsasatvatan, Maryam; Kohnehrouz, Bahram Baghban · 2023

Full title: The lyophilized chloroplasts store synthetic DARPin G3 as bioactive encapsulated organelles.

Authors: Ehsasatvatan, Maryam; Kohnehrouz, Bahram Baghban

DOI: https://doi.org/10.1186/s13036-023-00383-3

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Protein purification strategies must consider downstream applications and individual biological characteristics.

Remans, Kim; Lebendiker, Mario; Abreu, Celeste et al. · 2022

Full title: Protein purification strategies must consider downstream applications and individual biological characteristics.

Authors: Remans, Kim; Lebendiker, Mario; Abreu, Celeste; Maffei, Mariano; Sellathurai, Shaila; May, Marina M; Vaněk, Ondřej; de Marco, Ario

DOI: https://doi.org/10.1186/s12934-022-01778-5

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Downstream processing of recombinant human insulin and its analogues production from E. coli inclusion bodies.

Siew, Yin Yin; Zhang, Wei · 2021

Full title: Downstream processing of recombinant human insulin and its analogues production from E. coli inclusion bodies.

Authors: Siew, Yin Yin; Zhang, Wei

DOI: https://doi.org/10.1186/s40643-021-00419-w

Thesis

Resin Lifetime and Aging Behavior in Protein A Chromatography

Gooley, Sarah · 2024

Full title: Resin Lifetime and Aging Behavior in Protein A Chromatography

Authors: Gooley, Sarah

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/69585

Thesis

Eukaryotic expression, purification and structure/function analysis of native, recombinant CRISP3 from human and mouse

Volpert, M; Mangum, JE; Jamsai, D et al. · 2021

Full title: Eukaryotic expression, purification and structure/function analysis of native, recombinant CRISP3 from human and mouse

Authors: Volpert, M; Mangum, JE; Jamsai, D; D'Sylva, R; O'Bryan, MK; McIntyre, P

DOI: https://hdl.handle.net/11343/265721

Thesis

HIGH EFFICIENCY AFFINITY CAPTURE AND PURIFICATION OF IMMUNOGLOBULIN G USING MAGNETIC PARTICLES WITH BIOINSPIRIED PEPTIDE LIGANDS

Ou, Shih-Hao · 2019

Full title: HIGH EFFICIENCY AFFINITY CAPTURE AND PURIFICATION OF IMMUNOGLOBULIN G USING MAGNETIC PARTICLES WITH BIOINSPIRIED PEPTIDE LIGANDS

Authors: Ou, Shih-Hao

DOI: http://jhir.library.jhu.edu/handle/1774.2/61606

Thesis

Application of mechanistic modelling in membrane and fiber chromatography for purification of biotherapeutics — A review

Qu, Y; Baker, I; Black, J et al. · 2024

Full title: Application of mechanistic modelling in membrane and fiber chromatography for purification of biotherapeutics — A review

Authors: Qu, Y; Baker, I; Black, J; Fabri, L; Gras, SL; Lenhoff, AM; Kentish, SE

DOI: https://hdl.handle.net/11343/340258

Thesis

Establishment of a yeast-based VLP platform for antigen presentation

Wetzel, D; Rolf, T; Suckow, M et al. · 2020

Full title: Establishment of a yeast-based VLP platform for antigen presentation

Authors: Wetzel, D; Rolf, T; Suckow, M; Kranz, A; Barbian, A; Chan, JA; Leitsch, J; Weniger, M; Jenzelewski, V; Kouskousis, B; Palmer, C; Beeson, JG; Schembecker, G; Merz, J; Piontek, M

DOI: https://hdl.handle.net/11343/255894

Thesis

Eplt4 Proteinaceous Elicitor Produced in Pichia pastoris Has a Protective Effect Against Cercosporidium sofinum Infections of Soybean Leaves

Wang, Y; Song, J; Wu, Y et al. · 2021

Full title: Eplt4 Proteinaceous Elicitor Produced in Pichia pastoris Has a Protective Effect Against Cercosporidium sofinum Infections of Soybean Leaves

Authors: Wang, Y; Song, J; Wu, Y; Odeph, M; Liu, Z; Howlett, BJ; Wang, S; Yang, P; Yao, L; Zhao, L; Yang, Q

DOI: https://hdl.handle.net/11343/283084

Thesis

Digitalization in biopharmaceutical downstream processes

Espinoza, Daniel · 2024

Full title: Digitalization in biopharmaceutical downstream processes

Authors: Espinoza, Daniel

DOI: https://lup.lub.lu.se/record/f936d3e3-244e-4f3b-812a-6866d82a1eee

Thesis

Modeling and Optimization of an Integrated Column Sequence with In-Line Dilution for Continuous Chromatography of Proteins

Fridlund, Christian · 2016

Full title: Modeling and Optimization of an Integrated Column Sequence with In-Line Dilution for Continuous Chromatography of Proteins

Authors: Fridlund, Christian

DOI: http://lup.lub.lu.se/student-papers/record/8882081

Thesis

A Model-based Approach to Evaluating Chromatography Capture Steps

Ulmestig, Jakob · 2017

Full title: A Model-based Approach to Evaluating Chromatography Capture Steps

Authors: Ulmestig, Jakob

DOI: http://lup.lub.lu.se/student-papers/record/8928249

Thesis

Cloning, expression and production of Vicia faba Leghemoglobin B

Lindéus, Gustav · 2016

Full title: Cloning, expression and production of Vicia faba Leghemoglobin B

Authors: Lindéus, Gustav

DOI: http://lup.lub.lu.se/student-papers/record/8880323

Thesis

Performance analysis of a PEGylation process -Process comparison of a tubular reactor with recirculation to a conventional batch reactor

Torbica, Boris · 2015

Full title: Performance analysis of a PEGylation process -Process comparison of a tubular reactor with recirculation to a conventional batch reactor

Authors: Torbica, Boris

DOI: http://lup.lub.lu.se/student-papers/record/8052030

Thesis

Overexpression and Purification of Mouse Divalent Metal Transporter 1 (mDMT1) from Saccharomyces cerevisiae

Arbab, Olivia · 2016

Full title: Overexpression and Purification of Mouse Divalent Metal Transporter 1 (mDMT1) from Saccharomyces cerevisiae

Authors: Arbab, Olivia

DOI: http://lup.lub.lu.se/student-papers/record/8892046

Thesis

Small Scale Monoclonal Antibody Purification Platform

Nielsen, Eric · 2022

Full title: Small Scale Monoclonal Antibody Purification Platform

Authors: Nielsen, Eric

DOI: http://lup.lub.lu.se/student-papers/record/9075211

Thesis

Double-layer vs single-layer cryogels as a dye affinity chromatography column, comparison study

Trinh, Thi Hoai Thu · 2022

Full title: Double-layer vs single-layer cryogels as a dye affinity chromatography column, comparison study

Authors: Trinh, Thi Hoai Thu

DOI: http://lup.lub.lu.se/student-papers/record/9079984

Thesis

Optimization of Recombinant Phytoglobin Production

Rollén, Emelie; Bergström Gombrii, Hanna · 2025

Full title: Optimization of Recombinant Phytoglobin Production

Authors: Rollén, Emelie; Bergström Gombrii, Hanna

DOI: http://lup.lub.lu.se/student-papers/record/9198619

Thesis

Designing a Multifunctional Chromatography Stationary Phase for (Bio)Product Purification via Green Chemistry

Lei, Xiaolin · 2024

Full title: Designing a Multifunctional Chromatography Stationary Phase for (Bio)Product Purification via Green Chemistry

Authors: Lei, Xiaolin

DOI: http://lup.lub.lu.se/student-papers/record/9167848

Thesis

Model Calibration and Optimization of a Protein Purification Process

Al-Kaisy, Sadiq · 2015

Full title: Model Calibration and Optimization of a Protein Purification Process

Authors: Al-Kaisy, Sadiq

DOI: http://lup.lub.lu.se/student-papers/record/5470040

Thesis

Iterative Learning Control for Preparative Chromatography

Espinoza, Daniel · 2020

Full title: Iterative Learning Control for Preparative Chromatography

Authors: Espinoza, Daniel

DOI: http://lup.lub.lu.se/student-papers/record/9007394

Thesis

Elution Trajectory Optimization for Chromatographic Separation

Wacker, Philipp · 2025

Full title: Elution Trajectory Optimization for Chromatographic Separation

Authors: Wacker, Philipp

DOI: http://lup.lub.lu.se/student-papers/record/9193662

Thesis

Expression and purification of pyruvate transporting human mitochondrial pyruvate carrier (MPC) protein complex for structural studies

Wendler, Markus · 2022

Full title: Expression and purification of pyruvate transporting human mitochondrial pyruvate carrier (MPC) protein complex for structural studies

Authors: Wendler, Markus

DOI: http://lup.lub.lu.se/student-papers/record/9082213

Thesis

Protein Recovery from Alkaline Extracts: A Comparative Analysis of Isoelectric Precipitation and Ultrafiltration

Sharma, Anjay · 2023

Full title: Protein Recovery from Alkaline Extracts: A Comparative Analysis of Isoelectric Precipitation and Ultrafiltration

Authors: Sharma, Anjay

DOI: http://lup.lub.lu.se/student-papers/record/9140482

Thesis

Simulation of periodic counter-current chromatography purification of monoclonal antibodies with column degradation

Friberg, Erik · 2022

Full title: Simulation of periodic counter-current chromatography purification of monoclonal antibodies with column degradation

Authors: Friberg, Erik

DOI: http://lup.lub.lu.se/student-papers/record/9102373

Thesis

Optimizing Expression and Purification of HaTRPA1

Hansson Wennersten, Wilhelm · 2024

Full title: Optimizing Expression and Purification of HaTRPA1

Authors: Hansson Wennersten, Wilhelm

DOI: http://lup.lub.lu.se/student-papers/record/9159056

Thesis

A mutational analysis of the hinge region of the N-lobe of lactoferrin : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University

Shewry, Steven Christopher · 2018

Authors: Shewry, Steven Christopher

DOI: http://hdl.handle.net/10179/12822

Thesis

Expression, purification and mutagenesis of recombinant class 1 Aldehyde dehydrogenase : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Molecular Biology at Massey University /

Wyatt, Jane Margaret · 2018

Authors: Wyatt, Jane Margaret

DOI: http://hdl.handle.net/10179/12530

Thesis

Production of phospholipase A2 from recombinant yarrowia lipolytica biopharmaceutical application

Mokhtar, Nur'Ainun · 2013

Full title: Production of phospholipase A2 from recombinant yarrowia lipolytica biopharmaceutical application

Authors: Mokhtar, Nur'Ainun

DOI: http://psasir.upm.edu.my/id/eprint/38650/1/FPSK%28m%29%202013%2031%20IR.pdf

Thesis

Recovery of α-lactalbumin from whey protein isolate and osteopontin from milk by anion exchangers : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Chemistry at Massey University, New Zealand

Chen, Yishan · 2021

Authors: Chen, Yishan

DOI: http://hdl.handle.net/10179/15959

Thesis

Cloning, Expression and Characterization of Hepatitis B Large Surface Antigen In Yeast System

Mohamad Sinang, Fazia · 2010

Full title: Cloning, Expression and Characterization of Hepatitis B Large Surface Antigen In Yeast System

Authors: Mohamad Sinang, Fazia

DOI: http://psasir.upm.edu.my/id/eprint/21265/1/FBSB_2010_3_R.pdf

Thesis

Development of dye affinity adsorbents for recovery of polyclonal anti-hepatitis B core antigen immunoglobulin G

Wongchuphan, Rattana · 2010

Full title: Development of dye affinity adsorbents for recovery of polyclonal anti-hepatitis B core antigen immunoglobulin G

Authors: Wongchuphan, Rattana

DOI: http://psasir.upm.edu.my/id/eprint/41141/1/FK%202010%2076R.pdf

Thesis

Biomanufacturing of an organic solvent tolerant and thermostable lipase by recombinant E. coli

Nelofer, Rubina · 2012

Full title: Biomanufacturing of an organic solvent tolerant and thermostable lipase by recombinant E. coli

Authors: Nelofer, Rubina

DOI: http://psasir.upm.edu.my/id/eprint/33307/1/FBSB%202012%2019R.pdf

Thesis

Production and electrophoresis-based purification of recombinant green fluorescent protein from Escherichia coli

Chew, Few Ne · 2011

Full title: Production and electrophoresis-based purification of recombinant green fluorescent protein from Escherichia coli

Authors: Chew, Few Ne

DOI: http://psasir.upm.edu.my/id/eprint/42335/1/FK%202011%20103R.pdf

Thesis

Recovery and purification of epidermal growth factor from fermentation broth using expanded bed chromatography

Rosti, Ira Amira · 2013

Full title: Recovery and purification of epidermal growth factor from fermentation broth using expanded bed chromatography

Authors: Rosti, Ira Amira

DOI: http://psasir.upm.edu.my/id/eprint/40046/1/IB%202013%2019%20ir.pdf

Thesis

Purification of Human Interferon Alpha-2b from Eschericha Coli Using Aqueous Two-Phase Systems

Lin, Yu Kiat · 2011

Full title: Purification of Human Interferon Alpha-2b from Eschericha Coli Using Aqueous Two-Phase Systems

Authors: Lin, Yu Kiat

DOI: http://psasir.upm.edu.my/id/eprint/20038/1/IB_2011_10_ir.pdf

Thesis

Simple surface plasmon resonance bio-sensor for the quantification of recombinant human epidermal growth factor (rhEGF) in expanded bed recovery

Faizal Wong, Fadzlie Wong · 2010

Full title: Simple surface plasmon resonance bio-sensor for the quantification of recombinant human epidermal growth factor (rhEGF) in expanded bed recovery

Authors: Faizal Wong, Fadzlie Wong

DOI: http://psasir.upm.edu.my/id/eprint/41137/1/FK%202010%2073R.pdf

Thesis

Expanded bed anion exchange adsorption for the purification of bacteriophage M13

Shamsu Zaman, Mayamarni · 2009

Full title: Expanded bed anion exchange adsorption for the purification of bacteriophage M13

Authors: Shamsu Zaman, Mayamarni

DOI: http://psasir.upm.edu.my/id/eprint/51065/1/FK%202008%2097RR.pdf

Thesis

Direct Recovery of Recombinant Hepatitis B Core Antigen from Unclarified Escherichia Coli Feedstock Using Expanded Bed Adsorption Chromatography

Ng, Michelle Yeen Tan · 2008

Full title: Direct Recovery of Recombinant Hepatitis B Core Antigen from Unclarified Escherichia Coli Feedstock Using Expanded Bed Adsorption Chromatography

Authors: Ng, Michelle Yeen Tan

DOI: http://psasir.upm.edu.my/id/eprint/5392/1/IB_2008_5.pdf

Thesis

High throughput optimization of protein-A affinity chromatography for capture of humanized monoclonal antibody

Pakiman, Norazrina · 2012

Full title: High throughput optimization of protein-A affinity chromatography for capture of humanized monoclonal antibody

Authors: Pakiman, Norazrina

DOI: http://psasir.upm.edu.my/id/eprint/48480/1/FK%202012%20123R.pdf

Thesis

Development Of An Integrated Recovery Process For Recombinant Hepatitis B Core Antigen

Ho, Chin Woi · 2007

Full title: Development Of An Integrated Recovery Process For Recombinant Hepatitis B Core Antigen

Authors: Ho, Chin Woi

DOI: http://psasir.upm.edu.my/id/eprint/5210/1/FK_2007_27.pdf

Thesis

Establishment of optimise strategies in production of recombinant Hepatitis B surface antigen for chip-based antibody detection approach

Tam, Yew Joon · 2015

Full title: Establishment of optimise strategies in production of recombinant Hepatitis B surface antigen for chip-based antibody detection approach

Authors: Tam, Yew Joon

DOI: http://psasir.upm.edu.my/id/eprint/64029/1/IB%202015%2011.pdf

Thesis

Production and purification of nipah virus glycoprotein in Spodoptera frugiperda 9 (J.E. Smith) insect cell

Sunhare, Raksha · 2013

Full title: Production and purification of nipah virus glycoprotein in Spodoptera frugiperda 9 (J.E. Smith) insect cell

Authors: Sunhare, Raksha

DOI: http://psasir.upm.edu.my/id/eprint/40015/1/IB%202013%209.pdf

Thesis

The Influence Of M13 Bacteriophage On Protein Adsorption Using Anion Exchange Expanded Bed Chromatography

Mohamed @ Mahmood, Masniza · 2006

Full title: The Influence Of M13 Bacteriophage On Protein Adsorption Using Anion Exchange Expanded Bed Chromatography

Authors: Mohamed @ Mahmood, Masniza

DOI: http://psasir.upm.edu.my/id/eprint/5162/1/FK_2006_108a.pdf

Thesis

Expression And Characterization Of Recombinant Thermostable L2 Lipase In Pichia Pastoris

Sabri, Suriana · 2007

Full title: Expression And Characterization Of Recombinant Thermostable L2 Lipase In Pichia Pastoris

Authors: Sabri, Suriana

DOI: http://psasir.upm.edu.my/id/eprint/4857/1/FBSB_2007_1.pdf

Thesis

Expression of recombinant geobacillus SP a-amylase in pichia pastoris GS 115

Gandhi, Sivasangkary · 2014

Full title: Expression of recombinant geobacillus SP a-amylase in pichia pastoris GS 115

Authors: Gandhi, Sivasangkary

DOI: http://psasir.upm.edu.my/id/eprint/56821/1/IB%202014%2018.pdf

Thesis

Purification and characterization of polyclonal anti-hepatitis B core antigen immunoglobulin G from rabbit serum

Sayed Hitam, Sharifah Mariam · 2016

Full title: Purification and characterization of polyclonal anti-hepatitis B core antigen immunoglobulin G from rabbit serum

Authors: Sayed Hitam, Sharifah Mariam

DOI: http://psasir.upm.edu.my/id/eprint/69717/1/IB%202016%207%20IR.pdf

Thesis

Nucleocapsid and matrix proteins of nipah virus produced in Pichia pastoris and their interaction

Narcisse Mary, Sither Joseph Vesudian · 2016

Full title: Nucleocapsid and matrix proteins of nipah virus produced in Pichia pastoris and their interaction

Authors: Narcisse Mary, Sither Joseph Vesudian

DOI: http://psasir.upm.edu.my/id/eprint/68994/7/FBSB%202016%2012%20IR%20edit.pdf

Thesis

Facilitative recovery of cyclodextrin glucanotransferase using chromatographic strategies

Sivapragasam, Magaret · 2014

Full title: Facilitative recovery of cyclodextrin glucanotransferase using chromatographic strategies

Authors: Sivapragasam, Magaret

DOI: http://psasir.upm.edu.my/id/eprint/66665/1/IB%202014%2022%20IR.pdf

Thesis

Purification on a Recombinant Nucleocapsid Protein of Newcastle Disease Virus Using Expanded Bed Adsorption Chromatography

Tan, Yan Peng · 2005

Full title: Purification on a Recombinant Nucleocapsid Protein of Newcastle Disease Virus Using Expanded Bed Adsorption Chromatography

Authors: Tan, Yan Peng

DOI: http://psasir.upm.edu.my/id/eprint/6038/1/FK_2005_28.pdf

Thesis

Expression of recombinant thermostable W200R protease in Pichia pastoris

Mohamad Sultan, Muhamad Zarir · 2011

Full title: Expression of recombinant thermostable W200R protease in Pichia pastoris

Authors: Mohamad Sultan, Muhamad Zarir

DOI: http://psasir.upm.edu.my/id/eprint/67162/1/IB%202012%2028%20IR.pdf

Thesis

A Simplified and Selective Technique for The Direct Recovery of Glucose-6-Phosphate Dehydrogenase From Unclarified Yeast Feedstock

Chow, Yen Mei · 2005

Full title: A Simplified and Selective Technique for The Direct Recovery of Glucose-6-Phosphate Dehydrogenase From Unclarified Yeast Feedstock

Authors: Chow, Yen Mei

DOI: http://psasir.upm.edu.my/id/eprint/6036/1/FK_2005_27.pdf

Thesis

Periplasmic Expression, Recovery and Quantification of Recombinant Human Interferon-A2b in Fermentation by Escherichia Coli

Ramanan, R. Nagasundara · 2009

Full title: Periplasmic Expression, Recovery and Quantification of Recombinant Human Interferon-A2b in Fermentation by Escherichia Coli

Authors: Ramanan, R. Nagasundara

DOI: http://psasir.upm.edu.my/id/eprint/7552/1/ABS_---__IB_2009_13.pdf

Thesis

Purification of long helical capsid of newcastle disease virus from Escherichia coli

Yap, Chee Fai · 2013

Full title: Purification of long helical capsid of newcastle disease virus from Escherichia coli

Authors: Yap, Chee Fai

DOI: http://psasir.upm.edu.my/id/eprint/38658/1/IB%202013%205R.pdf

Thesis

Chromatographic Purification of Recombinant Nucleocapsid Protein of Nipah Virus from Escherichia Coli Homogenate

Chong, Fui Chin · 2010

Full title: Chromatographic Purification of Recombinant Nucleocapsid Protein of Nipah Virus from Escherichia Coli Homogenate

Authors: Chong, Fui Chin

DOI: http://psasir.upm.edu.my/id/eprint/7849/1/ABS_%3D%3D%3D%3D__FK_2010_3.pdf

Thesis

Development of molecular tools for Komagataella phaffii and exploring its use for orally administered biopharmaceuticals

Vanluchene, Robin · 2020

Full title: Development of molecular tools for Komagataella phaffii and exploring its use for orally administered biopharmaceuticals

Authors: Vanluchene, Robin

DOI: https://biblio.ugent.be/publication/8684279

Thesis

Mechanistic modeling and scale-up investigation of a preparative two-column purification step for a biopharmaceutical polypeptide

Koch, Jonas Martin Maria · 2024

Full title: Mechanistic modeling and scale-up investigation of a preparative two-column purification step for a biopharmaceutical polypeptide

Authors: Koch, Jonas Martin Maria

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/34272/1/Dissertation_Koch_Jonas.pdf

Thesis

Production of biosimilar trastuzumab in plants: Expression, purification, and analysis of function

Grohs, Brittany Marie · 2020

Full title: Production of biosimilar trastuzumab in plants: Expression, purification, and analysis of function

Authors: Grohs, Brittany Marie

DOI: https://hdl.handle.net/10214/21780

Thesis

Characterization of excipients for their application during purification of monoclonal antibodies and other therapeutic proteins

Stange, Carolin · 2023

Full title: Characterization of excipients for their application during purification of monoclonal antibodies and other therapeutic proteins

Authors: Stange, Carolin

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/33181/1/Dissertation_Carolin%20Stange.pdf

Thesis

Separation and characterization of antibody-based protein variants in column chromatography for the production of biopharmaceuticals

Sanchez Reyes, Gabriela · 2022

Full title: Separation and characterization of antibody-based protein variants in column chromatography for the production of biopharmaceuticals

Authors: Sanchez Reyes, Gabriela

DOI: https://archiv.ub.uni-heidelberg.de/volltextserver/30762/1/Dissertation_Sanchez%20Reyes%20Gabriela_FINAL.pdf

Thesis

Biosynthetic isotopic labelling strategies for the production of membrane proteins for solid-state Nuclear Magnetic Resonance spectroscopy

Munro, Rachel · 2021

Full title: Biosynthetic isotopic labelling strategies for the production of membrane proteins for solid-state Nuclear Magnetic Resonance spectroscopy

Authors: Munro, Rachel

DOI: https://hdl.handle.net/10214/23722

Thesis

Recombinant Production of Growth Factors and Antimicrobial Peptides Using Microorganisms to Modulate Tissue Damage Healing

Huynh, Evanna · 2016

Full title: Recombinant Production of Growth Factors and Antimicrobial Peptides Using Microorganisms to Modulate Tissue Damage Healing

Authors: Huynh, Evanna

DOI: http://hdl.handle.net/10214/9445

Thesis

Solid Binding Peptides: Applications in Affinity Protein Purification and Bioprotonic Devices

Soto-Rodriguez, Jessica · 2019

Full title: Solid Binding Peptides: Applications in Affinity Protein Purification and Bioprotonic Devices

Authors: Soto-Rodriguez, Jessica

DOI: http://hdl.handle.net/1773/43321

Thesis

Tools for the development of intensified perfusion processes for mammalian cell culture

Schwarz, Hubert · 2022

Full title: Tools for the development of intensified perfusion processes for mammalian cell culture

Authors: Schwarz, Hubert

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-312457

Thesis

Interaction engineered three-helix bundle domains for protein recovery and detection

Alm, Tove · 2010

Full title: Interaction engineered three-helix bundle domains for protein recovery and detection

Authors: Alm, Tove

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-12823

Thesis

Characterization of Antigenic Properties and High Throughput Protein Purification

Steen, Johanna · 2010

Full title: Characterization of Antigenic Properties and High Throughput Protein Purification

Authors: Steen, Johanna

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-25841

Thesis

Calcium-dependent Affinity Domains for the Purification of Antibodies and Antibody Fragments

Scheffel, Julia · 2022

Full title: Calcium-dependent Affinity Domains for the Purification of Antibodies and Antibody Fragments

Authors: Scheffel, Julia

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-309572

Thesis

Engineering Proteinaceous Ligands for Improved Performance in Affinity Chromatography Applications

Gülich, Susanne · 2002

Full title: Engineering Proteinaceous Ligands for Improved Performance in Affinity Chromatography Applications

Authors: Gülich, Susanne

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3327

Thesis

Magnetic bead-based isolation of biological therapeutic modalities

Brechmann, Nils A. · 2022

Full title: Magnetic bead-based isolation of biological therapeutic modalities

Authors: Brechmann, Nils A.

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-321336

Thesis

Strategies for facilitated protein recovery after recombinant production in Escherichia coli

Hedhammar, My · 2005

Full title: Strategies for facilitated protein recovery after recombinant production in Escherichia coli

Authors: Hedhammar, My

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-471

Thesis

Protein engineering to explore and improve affinity ligands

Linhult, Martin · 2003

Full title: Protein engineering to explore and improve affinity ligands

Authors: Linhult, Martin

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3632

Thesis

Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Hong, Moo Sun · 2022

Full title: Model-based Design and Control of Biopharmaceutical Manufacturing Processes

Authors: Hong, Moo Sun

DOI: https://hdl.handle.net/1721.1/138943

Thesis

Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Maloney, Andrew John · 2025

Full title: Case studies in the modeling and control of continuous pharmaceutical manufacturing processes

Authors: Maloney, Andrew John

DOI: https://hdl.handle.net/1721.1/158315

Thesis

Characterization and application of vortex flow adsorption for simplification of biochemical product downstream processing

Ma, Junfen, 1972- · 2005

Full title: Characterization and application of vortex flow adsorption for simplification of biochemical product downstream processing

Authors: Ma, Junfen, 1972-

DOI: http://hdl.handle.net/1721.1/17010

Thesis

Purification of recombinant proteins with magnetic nanoclusters

Ditsch, Andre (Andre Paul) · 2006

Full title: Purification of recombinant proteins with magnetic nanoclusters

Authors: Ditsch, Andre (Andre Paul)

DOI: http://hdl.handle.net/1721.1/34160

Thesis

Creating an Efficient Biopharmaceutical Factory: Protein Expression and Purification Using a Self-Cleaving Split Intein

Cooper, Merideth A. · 2018

Full title: Creating an Efficient Biopharmaceutical Factory: Protein Expression and Purification Using a Self-Cleaving Split Intein

Authors: Cooper, Merideth A.

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu152226172238882

Thesis

Developing Molecular Tools for Applications in Metabolic Engineering and ProteinPurification

lahiry, ashwin · 2017

Full title: Developing Molecular Tools for Applications in Metabolic Engineering and ProteinPurification

Authors: lahiry, ashwin

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1502109789024711

Thesis

Utilizing Commercially Scalable Methods for Isolating and Generating Bioactive Compounds from Bovine Dairy Byproducts

Tam, Andrea Jiabao Chao · 2023

Full title: Utilizing Commercially Scalable Methods for Isolating and Generating Bioactive Compounds from Bovine Dairy Byproducts

Authors: Tam, Andrea Jiabao Chao

DOI: https://escholarship.org/uc/item/1h52p8pz

Thesis

Solid Substrate for High Throughput Protein Chromatography

Alvarez, Adrian · 2018

Full title: Solid Substrate for High Throughput Protein Chromatography

Authors: Alvarez, Adrian

DOI: https://escholarship.org/uc/item/7hd470qf

Thesis

Plant Molecular Pharming Techno-Economic and Virus-Based Nanomaterial Approaches to Limited Resource Recombinant Protein Manufacturing

McNulty, Matthew · 2022

Full title: Plant Molecular Pharming Techno-Economic and Virus-Based Nanomaterial Approaches to Limited Resource Recombinant Protein Manufacturing

Authors: McNulty, Matthew

DOI: https://escholarship.org/uc/item/66w9s6ht

Thesis

Scalable Purification of Ultra-Pure Lumbricus terrestris Mega-Hemoglobin and Surface Modification using Bio-compatible Polymers for use as an Oxygen Therapeutic

Savla, Chintan · 2023

Full title: Scalable Purification of Ultra-Pure Lumbricus terrestris Mega-Hemoglobin and Surface Modification using Bio-compatible Polymers for use as an Oxygen Therapeutic

Authors: Savla, Chintan

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1681905710885225

Thesis

Split Intein Applications for Downstream Purification and Protein Conjugation

Galiardi, Jackelyn · 2021

Full title: Split Intein Applications for Downstream Purification and Protein Conjugation

Authors: Galiardi, Jackelyn

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1618931990774251

Thesis

Split Inteins As Versatile Tools in Applications of Downstream Purification and Bioconjugation

Fan, Yamin · 2019

Full title: Split Inteins As Versatile Tools in Applications of Downstream Purification and Bioconjugation

Authors: Fan, Yamin

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu155508523693651

Thesis

Control of Intein-Mediated Self-Cleaving Tag for Recombinant Protein Purification

Han, Tzu-Chiang · 2016

Full title: Control of Intein-Mediated Self-Cleaving Tag for Recombinant Protein Purification

Authors: Han, Tzu-Chiang

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1453206997

Thesis

Recent Advances in Developing Molecular Biotechnology Tools for Metabolic Engineering and Recombinant Protein Purification

Stimple, Samuel Douglas · 2018

Full title: Recent Advances in Developing Molecular Biotechnology Tools for Metabolic Engineering and Recombinant Protein Purification

Authors: Stimple, Samuel Douglas

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1514494485801145

Thesis

Advances in affinity-based methods for downstream process development of monoclonal antibody and recombinant protein therapeutics

Prabhala, Sai Vivek · 2023

Full title: Advances in affinity-based methods for downstream process development of monoclonal antibody and recombinant protein therapeutics

Authors: Prabhala, Sai Vivek

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu1700243307178593

Thesis

Development of a Novel Intein-Mediated Affinity Capture Platform for Production of Recombinant Proteins and Biopharmaceuticals

Taris, Joseph Edward · 2021

Full title: Development of a Novel Intein-Mediated Affinity Capture Platform for Production of Recombinant Proteins and Biopharmaceuticals

Authors: Taris, Joseph Edward

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu163853540249581

Thesis

Multi-stage Aqueous Two-Phase Extraction

Chandler, Emma · 2021

Full title: Multi-stage Aqueous Two-Phase Extraction

Authors: Chandler, Emma

DOI: https://etheses.whiterose.ac.uk/id/eprint/29388/1/Multi-stage%20Aqueous%20Two-Phase%20Extraction.pdf

Thesis

The affinity precipitation for the isolation of biomolecules

Stocker Majd, Gisela · 2007

Full title: The affinity precipitation for the isolation of biomolecules

Authors: Stocker Majd, Gisela

DOI: https://infoscience.epfl.ch/handle/20.500.14299/7866

Thesis

Evaluating Improvements and Challenges in Affinity Chromatography for AAV Purification

Dachenko, Alexandra · 2023

Full title: Evaluating Improvements and Challenges in Affinity Chromatography for AAV Purification

Authors: Dachenko, Alexandra

DOI: https://jscholarship.library.jhu.edu/handle/1774.2/69011

Thesis

Bioprocess development: extraction and purification of human serum albumin from transgenic rice

Sheshukova, Kseniya Alekseyevna · 2019

Full title: Bioprocess development: extraction and purification of human serum albumin from transgenic rice

Authors: Sheshukova, Kseniya Alekseyevna

DOI: http://hdl.handle.net/2097/39681

Thesis

Design and Control of Integrated Continuous Processes for the Purification of Biopharmaceuticals

Gomis Fons, Joaquin · 2022

Full title: Design and Control of Integrated Continuous Processes for the Purification of Biopharmaceuticals

Authors: Gomis Fons, Joaquin

DOI: https://lup.lub.lu.se/record/7de201f7-6a1b-4772-b3d1-e5d221e9515c

Thesis

Antibody-Fragments: Protein Engineering, Process Development, and their Application as Affinity Ligands

Sakhnini, Laila · 2019

Full title: Antibody-Fragments: Protein Engineering, Process Development, and their Application as Affinity Ligands

Authors: Sakhnini, Laila

DOI: https://lup.lub.lu.se/record/3156874d-3d8d-41ad-bd7a-6be6ffb8e037

Thesis

Developing integrated downstream processes for next-generation biologics

Löfgren, Anton · 2020

Full title: Developing integrated downstream processes for next-generation biologics

Authors: Löfgren, Anton

DOI: https://lup.lub.lu.se/record/31772706-1f08-4ef5-b61e-db17291cd22b

Thesis

CUSTOMIZED QUANTIFICATION OF HOST CELL PROTEIN WITH BIO-LAYER INTERFEROMETRY

Sjöblom, Eva · 2020

Full title: CUSTOMIZED QUANTIFICATION OF HOST CELL PROTEIN WITH BIO-LAYER INTERFEROMETRY

Authors: Sjöblom, Eva

DOI: http://lup.lub.lu.se/student-papers/record/9032572

Thesis

Composite Cryogels: Stationary Phase for Separation of Complex Media

Hajizadeh, Solmaz · 2012

Full title: Composite Cryogels: Stationary Phase for Separation of Complex Media

Authors: Hajizadeh, Solmaz

DOI: https://lup.lub.lu.se/record/3165833

Thesis

Cryogels as Solid Supports in Bioprocessing

Jespersen, Gry · 2014

Full title: Cryogels as Solid Supports in Bioprocessing

Authors: Jespersen, Gry

DOI: https://lup.lub.lu.se/record/4318450

Thesis

Orbit-simulator for downstream processes

Malmström, Andreas · 2022

Full title: Orbit-simulator for downstream processes

Authors: Malmström, Andreas

DOI: http://lup.lub.lu.se/student-papers/record/9077663

Thesis

Matrix-assisted protein refolding

Dashivets, Tetyana · 2015

Full title: Matrix-assisted protein refolding

Authors: Dashivets, Tetyana

DOI: https://mediatum.ub.tum.de/1087053

Thesis

Integrated Continuous Downstream Processing of Biopharmaceuticals

Isaksson, Madelène · 2025

Full title: Integrated Continuous Downstream Processing of Biopharmaceuticals

Authors: Isaksson, Madelène

DOI: https://lup.lub.lu.se/record/30d11714-b846-42b4-8361-67da8137b563

Thesis

Protein Crystallization in Stirred-Tank Reactors

Hebel, Dirk Peter · 2013

Full title: Protein Crystallization in Stirred-Tank Reactors

Authors: Hebel, Dirk Peter

DOI: https://mediatum.ub.tum.de/1115472

Thesis

Enrichment Behavior of Immunoglobulin by Foam Fractionation Using Response Surface Methodology

Chen, Yen-Chih · 2018

Full title: Enrichment Behavior of Immunoglobulin by Foam Fractionation Using Response Surface Methodology

Authors: Chen, Yen-Chih

DOI: https://mediatum.ub.tum.de/1083287

Thesis

Fractionation of major and minor Whey Proteins using Membrane-based Ion-exchange Chromatography

Voswinkel, Linda Elisabeth · 2017

Full title: Fractionation of major and minor Whey Proteins using Membrane-based Ion-exchange Chromatography

Authors: Voswinkel, Linda Elisabeth

DOI: https://mediatum.ub.tum.de/1292689

Thesis

Membrane adsorbers and novel affinity peptides for recombinant protein purification

Weaver, Justin, author; Wickramasinghe, S. Ranil, advisor; Qian, Xianghong, committee member et al. · 2015

Full title: Membrane adsorbers and novel affinity peptides for recombinant protein purification

Authors: Weaver, Justin, author; Wickramasinghe, S. Ranil, advisor; Qian, Xianghong, committee member; Carlson, Jon O., committee member; Bailey, Travis S., committee member

DOI: http://hdl.handle.net/10217/166862

Thesis

Production of a SARS-CoV-2 Spike Protein Vaccine Using the Baculovirus Expression Vector System

Adler, Rachel; Kelsey, Nathan; Maik, Michelle et al. · 2023

Full title: Production of a SARS-CoV-2 Spike Protein Vaccine Using the Baculovirus Expression Vector System

Authors: Adler, Rachel; Kelsey, Nathan; Maik, Michelle; Song, Jun Ho

DOI: https://repository.upenn.edu/handle/20.500.14332/5955

Thesis

Optimization of Oleosin 30G Production for Echocardiography

Krysiewicz, Annette; Parsons, Andrew; Rodriguez-Labra, Sergio · 2023

Full title: Optimization of Oleosin 30G Production for Echocardiography

Authors: Krysiewicz, Annette; Parsons, Andrew; Rodriguez-Labra, Sergio

DOI: https://repository.upenn.edu/handle/20.500.14332/6054

Thesis

Design of bacterial polyester beads for recombinant protein production, biomolecule separation and detection : a thesis presented in partial fulfilment of the requirements of the degree of Doctor of Philosophy in Microbiology at Massey University, Palmerston North, New Zealand

Du, Jinping · 2020

Authors: Du, Jinping

DOI: http://hdl.handle.net/10179/15326

Thesis

Heterologous expression of rat ST6Gal-I in Pichia pastoris for structural and functional studies

Tejwani, Narendra Gurnamal · 2024

Full title: Heterologous expression of rat ST6Gal-I in Pichia pastoris for structural and functional studies

Authors: Tejwani, Narendra Gurnamal

DOI: https://openscholar.uga.edu/record/13452/files/tejwani_narendra_g_200812_phd.pdf

Thesis

Expression, purification and characterisation of antimicrobial peptides of human and bovine lactoferrins : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, Palmerston North, New Zealand

Rallabhandi, Venkata Siva Prasad Sarma · 2012

Authors: Rallabhandi, Venkata Siva Prasad Sarma

DOI: http://hdl.handle.net/10179/3608

Thesis

Efficiency of two cation exchange methods for isolating lactoperoxidase and lactoferrin from Gouda and Cheddar cheese whey

· 2013

Full title: Efficiency of two cation exchange methods for isolating lactoperoxidase and lactoferrin from Gouda and Cheddar cheese whey

DOI: http://hdl.handle.net/2263/29897

Thesis

Protein Recovery from Potato Processing Effluent Stream Using Ultrafiltration Membrane

Dabestani, Shirin Sadat · 2017

Full title: Protein Recovery from Potato Processing Effluent Stream Using Ultrafiltration Membrane

Authors: Dabestani, Shirin Sadat

DOI: http://hdl.handle.net/1959.4/58525

Thesis

Purification of an acidic recombinant protein from transgenic tobacco

Holler, Christopher J. · 2014

Full title: Purification of an acidic recombinant protein from transgenic tobacco

Authors: Holler, Christopher J.

DOI: http://hdl.handle.net/10919/32379

Thesis

Downstream processing of recombinant and endogenous proteins from livestock milk

Degener, Arthur W. Jr. · 2014

Full title: Downstream processing of recombinant and endogenous proteins from livestock milk

Authors: Degener, Arthur W. Jr.

DOI: http://hdl.handle.net/10919/27183

Thesis

Optimization of the production of recombinant macrophage inhibitory cytokine 1 (MIC-1) from Pichia pastoris

Pratanaphon, Ronachai · 2006

Full title: Optimization of the production of recombinant macrophage inhibitory cytokine 1 (MIC-1) from Pichia pastoris

Authors: Pratanaphon, Ronachai

DOI: http://hdl.handle.net/1959.4/68401

Thesis

Purification of the major envelope protein GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) from native virions

Matanin, Brad Matthew · 2014

Full title: Purification of the major envelope protein GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) from native virions

Authors: Matanin, Brad Matthew

DOI: http://hdl.handle.net/10919/33194

Thesis

Design of anion exchange cellulose hydrogel for large proteins

Kumar, Guneet · 2014

Full title: Design of anion exchange cellulose hydrogel for large proteins

Authors: Kumar, Guneet

DOI: http://hdl.handle.net/10919/38250

Thesis

Technology development for the over-expression, purification and crystallisation of human membrane proteins

Young, Gillian · 2011

Full title: Technology development for the over-expression, purification and crystallisation of human membrane proteins

Authors: Young, Gillian

DOI: https://theses.gla.ac.uk/2539/1/2010YoungPhD.pdf

Thesis

Antibody Purification from Tobacco by Protein A Affinity Chromatography

Hey, Carolyn McKenzie · 2014

Full title: Antibody Purification from Tobacco by Protein A Affinity Chromatography

Authors: Hey, Carolyn McKenzie

DOI: http://hdl.handle.net/10919/42645

Thesis

Production of native flagellin from Salmonella Typhimurium in a bioreactor and purification by tangential ultrafiltration

Takagi, M. · 2011

Full title: Production of native flagellin from Salmonella Typhimurium in a bioreactor and purification by tangential ultrafiltration

Authors: Takagi, M.

DOI: https://doi.org/10.1590/s0104-66322011000400003

Thesis

Applications of recombinant Pichia pastoris in the healthcare industry

Farías, Jorge G · 2013

Full title: Applications of recombinant Pichia pastoris in the healthcare industry

Authors: Farías, Jorge G

DOI: http://www.scielo.br/pdf/bjm/v44n4/04.pdf

Thesis

Evaluation of Phenomena that Determine the Performance of Immunoaffinity, Peptide-Based and Ion Exchange Affinity Sorbents

Sines, Brian James · 2014

Full title: Evaluation of Phenomena that Determine the Performance of Immunoaffinity, Peptide-Based and Ion Exchange Affinity Sorbents

Authors: Sines, Brian James

DOI: http://hdl.handle.net/10919/29841

Thesis

Identification of the factors impacting immunosorbent performance

Subramanian, Anuradha · 2014

Full title: Identification of the factors impacting immunosorbent performance

Authors: Subramanian, Anuradha

DOI: http://hdl.handle.net/10919/38450

Thesis

Microcapillary membranes for purification of biomolecules

Mandal, Ipshita · 2016

Full title: Microcapillary membranes for purification of biomolecules

Authors: Mandal, Ipshita

DOI: https://www.repository.cam.ac.uk/handle/1810/255867

Thesis

Separation of Recombinant β-Glucuronidase from Transgenic Tobacco by Aqueous Two-Phase Extraction

Ross, Kristin Coby · 2014

Full title: Separation of Recombinant β-Glucuronidase from Transgenic Tobacco by Aqueous Two-Phase Extraction

Authors: Ross, Kristin Coby

DOI: http://hdl.handle.net/10919/43471

Thesis

A step forward in recombinant protein production regulated by the constitutive GAP promoter in Pichia pastoris through bioprocess engineering approaches

Garcia Ortega, Xavier · 2016

Full title: A step forward in recombinant protein production regulated by the constitutive GAP promoter in Pichia pastoris through bioprocess engineering approaches

Authors: Garcia Ortega, Xavier

DOI: http://hdl.handle.net/10803/384531

Thesis

L-Asparaginase from Penicillium sizovae produced by a recombinant Komagataella phaffii strain

Pérola O. Magalhães · 2022

Full title: L-Asparaginase from Penicillium sizovae produced by a recombinant Komagataella phaffii strain

Authors: Pérola O. Magalhães

DOI: https://doi.org/10.3390/ph15060746

Thesis

Expression and Mutagenesis studies of Candida antactica lipase B

Rotticci-Mulder, Johanna C. · 2003

Full title: Expression and Mutagenesis studies of Candida antactica lipase B

Authors: Rotticci-Mulder, Johanna C.

DOI: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3493

Thesis

Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties

Nordin, Joel Z.; Lee, Yi; Vader, Pieter et al. · 2015

Full title: Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties

DOI: https://dspace.library.uu.nl/handle/1874/332511

Thesis

Going native: Complete removal of protein purification affinity tags by simple modification of existing tags and proteases

Goh, Hui Chin; Sobota, Radoslaw M.; Ghadessy, Farid J. et al. · 2017

Full title: Going native: Complete removal of protein purification affinity tags by simple modification of existing tags and proteases

Authors: Goh, Hui Chin; Sobota, Radoslaw M.; Ghadessy, Farid J.; Nirantar, Saurabh

DOI: https://hdl.handle.net/10356/83191

Thesis

Optimized protocol for expression and purification of membrane-bound PglB, a bacterial oligosaccharyl transferase

Jaffee, Marcie Beth; Imperiali, Barbara · 2017

Full title: Optimized protocol for expression and purification of membrane-bound PglB, a bacterial oligosaccharyl transferase

Authors: Jaffee, Marcie Beth; Imperiali, Barbara

DOI: http://hdl.handle.net/1721.1/110397

Thesis

Rapid Developability Assessments to Formulate Recombinant Protein Antigens as Stable, Low-Cost, Multi-Dose Vaccine Candidates: Case-Study With Non-Replicating Rotavirus (NRRV) Vaccine Antigens

Sawant, Nishant; Kaur, Kawaljit; Holland, David A et al. · 2021

DOI: https://hdl.handle.net/1721.1/134368

Thesis

Data concerning the chromatographic isolation of bovine IgG from milk- and colostral whey

Heidebrecht, Hans-Jürgen; Kainz, Bernadette; Schopf, Roland et al. · 2018

Full title: Data concerning the chromatographic isolation of bovine IgG from milk- and colostral whey

Authors: Heidebrecht, Hans-Jürgen; Kainz, Bernadette; Schopf, Roland; Godl, Klaus; Karcier, Züleyha; Kulozik, Ulrich; Förster, Beatrix

DOI: https://dspace.library.uu.nl/handle/1874/384260

Thesis

Isolation of biofunctional bovine immunoglobulin G from milk- and colostral whey with mixed-mode chromatography at lab and pilot scale

Heidebrecht, Hans-Jürgen; Kainz, Bernadette; Schopf, Roland et al. · 2018

Full title: Isolation of biofunctional bovine immunoglobulin G from milk- and colostral whey with mixed-mode chromatography at lab and pilot scale

Authors: Heidebrecht, Hans-Jürgen; Kainz, Bernadette; Schopf, Roland; Godl, Klaus; Karcier, Züleyha; Kulozik, Ulrich; Förster, Beatrix

DOI: https://dspace.library.uu.nl/handle/1874/384261

Thesis

On-demand manufacturing of clinical-quality biopharmaceuticals

Crowell, Laura E; Lu, Amos E; Love, Kerry R et al. · 2021

Full title: On-demand manufacturing of clinical-quality biopharmaceuticals

DOI: https://hdl.handle.net/1721.1/134719

Thesis

Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care

Cleto, Sara; Lee, Kevin; Perez-Pinera, Pablo et al. · 2017

Full title: Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care

Authors: Cleto, Sara; Lee, Kevin; Perez-Pinera, Pablo; Han, Ningren; Cao, Jicong; Purcell, Oliver; Shah, Kartik A; Ram, Rajeev J; Lu, Timothy K

DOI: http://hdl.handle.net/1721.1/109076

Thesis

Versatile and on-demand biologics co-production in yeast

Cao, Jicong; Perez-Pinera, Pablo; Lowenhaupt, Ky et al. · 2018

Full title: Versatile and on-demand biologics co-production in yeast

Authors: Cao, Jicong; Perez-Pinera, Pablo; Lowenhaupt, Ky; Wu, Ming-Ru; Purcell, Oliver; de la Fuente-Nunez, Cesar; Lu, Timothy K.; de la Fuente Nunez, Cesar; Lu, Timothy K

DOI: http://hdl.handle.net/1721.1/115215

Thesis

Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus

Dalvie, Neil C; Brady, Joseph R; Crowell, Laura E et al. · 2021

Full title: Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus

DOI: https://hdl.handle.net/1721.1/136780

Thesis

Rapid optimization of processes for the integrated purification of biopharmaceuticals

Crowell, Laura E; Rodriguez, Sergio A; Love, Kerry R et al. · 2021

Full title: Rapid optimization of processes for the integrated purification of biopharmaceuticals

Authors: Crowell, Laura E; Rodriguez, Sergio A; Love, Kerry R; Cramer, Steven M; Love, J Christopher

DOI: https://hdl.handle.net/1721.1/135519

Thesis

Understanding electrostatic interaction on strong cation-exchanger via co-ion valency effects

Essert, GM; de Souza, JP; Schwaminger, SP et al. · 2024

Full title: Understanding electrostatic interaction on strong cation-exchanger via co-ion valency effects

Authors: Essert, GM; de Souza, JP; Schwaminger, SP; Bazant, MZ; Berensmeier, S

DOI: https://hdl.handle.net/1721.1/157408

Thesis

Purification of recombinant proteins

Rutt, George Clifford · 2008

Full title: Purification of recombinant proteins

Authors: Rutt, George Clifford

DOI: http://hdl.handle.net/1721.1/42614

Thesis

DESIGN OF RECOMBINANT TENEBRIO MOLITOR ANTIFREEZE PROTEIN FOR PURIFICATION USING ELASTIN-LIKE POLYPEPTIDE TAG

OH, JOONGSEOK · 2014

Full title: DESIGN OF RECOMBINANT TENEBRIO MOLITOR ANTIFREEZE PROTEIN FOR PURIFICATION USING ELASTIN-LIKE POLYPEPTIDE TAG

Authors: OH, JOONGSEOK

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=csu1409230499

Thesis

Scale-up of affinity chromatography for protein purifications

Hsu, Kuang-Hsin · 2000

Full title: Scale-up of affinity chromatography for protein purifications

Authors: Hsu, Kuang-Hsin

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1172002240

Thesis

Column-free Purification Method for Recombinant Proteins Using a Self-Cleaving Aggregating tag

Miozzi, Jackelyn · 2018

Full title: Column-free Purification Method for Recombinant Proteins Using a Self-Cleaving Aggregating tag

Authors: Miozzi, Jackelyn

DOI: http://rave.ohiolink.edu/etdc/view?acc_num=osu15229401048581

Thesis

Purifikace rekombinantních proteinů pomocí afinitní chromatografie

Zemek, Ondřej · 2017

Full title: Purifikace rekombinantních proteinů pomocí afinitní chromatografie

Authors: Zemek, Ondřej

DOI: http://hdl.handle.net/20.500.11956/39620

Thesis

Human granulocyte colony stimulating factor (hG-CSF): cloning, overexpression, purification and characterization

Vanz, Ana L. S.; Renard, Gaby; Palma, Mario Sergio [UNESP] et al. · 2014

Full title: Human granulocyte colony stimulating factor (hG-CSF): cloning, overexpression, purification and characterization

Authors: Vanz, Ana L. S.; Renard, Gaby; Palma, Mario Sergio [UNESP]; Chies, Jocelei M.; Dalmora, Sergio L.; Basso, Luiz A.; Santos, Diogenes S.

DOI: http://dx.doi.org/10.1186/1475-2859-7-13

Thesis

Synthesis of human bone morphogenetic protein-2 (Hbmp-2) in e. coli periplasmic space: its characterization and preclinical testing

Oliveira, João E.; Suzuki, Miriam F.; Damiani, Renata et al. · 2022

Full title: Synthesis of human bone morphogenetic protein-2 (Hbmp-2) in e. coli periplasmic space: its characterization and preclinical testing

DOI: http://dx.doi.org/10.3390/cells10123525

Thesis

Avaliação teórica da separação de xilanase produzida por Escherichia coli a partir dos processos de filtração e centrifugação com uso de floculante

Fuzaro, Maria Claudia Correia [UNESP] · 2025

Full title: Avaliação teórica da separação de xilanase produzida por Escherichia coli a partir dos processos de filtração e centrifugação com uso de floculante

Authors: Fuzaro, Maria Claudia Correia [UNESP]

DOI: https://hdl.handle.net/11449/311794

Thesis

HPLC for at-line reaction monitoring and purification improves yield and purity of tRNA

Megušar, Polona; Calder, Ewen; Vodopivec Seravalli, Tina et al. · 2024

Full title: HPLC for at-line reaction monitoring and purification improves yield and purity of tRNA

Authors: Megušar, Polona; Calder, Ewen; Vodopivec Seravalli, Tina; Lebar, Sergeja; Walport, Louise; Sekirnik, Rok

DOI: https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2024.1443917/abstract

Thesis

Insight into purification of monoclonal antibodies in industrial columns via studies of Protein A binding capacity by in situ ATR-FTIR spectroscopy

Beattie, james; Rowland-Jones, Ruth; Farys, Monika et al. · 2021

Full title: Insight into purification of monoclonal antibodies in industrial columns via studies of Protein A binding capacity by in situ ATR-FTIR spectroscopy

Authors: Beattie, james; Rowland-Jones, Ruth; Farys, Monika; Kucia-Tran, Richard; Kazarian, Sergei; Byrne, Bernadette

DOI: https://pubs.rsc.org/en/content/articlelanding/2021/AN/D1AN00985K

Thesis

Lysozyme Separation from Tobacco Extract by Aqueous Two-Phase Extraction

Balasubramaniam, Deepa · 2014

Full title: Lysozyme Separation from Tobacco Extract by Aqueous Two-Phase Extraction

Authors: Balasubramaniam, Deepa

DOI: http://hdl.handle.net/10919/31272

Thesis

Monoclonal Antibody Expression and Novel Purification in Nicotiana benthamiana

Fulton, Andrew Dale · 2014

Full title: Monoclonal Antibody Expression and Novel Purification in Nicotiana benthamiana

Authors: Fulton, Andrew Dale

DOI: http://hdl.handle.net/10919/43361

Thesis

Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris.

Whyteside, Graham; Alcocer, Marcos JC; Kumita, Janet R et al. · 2020

Full title: Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris.

Authors: Whyteside, Graham; Alcocer, Marcos JC; Kumita, Janet R; Dobson, Christopher M; Lazarou, Maria; Pleass, Richard J; Archer, David B

DOI: https://www.repository.cam.ac.uk/handle/1810/309386

Thesis

Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel et al. · 2025

Full title: Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Authors: Narayanan, Harini; Hinckley, Joshua A; Barry, Rachel; Dang, Brendan; Wolffe, Lenna A; Atari, Adel; Tseng, Yuen-Yi; Love, J Christopher

DOI: https://hdl.handle.net/1721.1/163220

Thesis

Enhancing Protein Crystal Nucleation Using In Situ Templating on Bioconjugate-Functionalized Nanoparticles and Machine Learning

McCue, Caroline; Girard, Henri-Louis; Varanasi, Kripa K. · 2024

Full title: Enhancing Protein Crystal Nucleation Using In Situ Templating on Bioconjugate-Functionalized Nanoparticles and Machine Learning

Authors: McCue, Caroline; Girard, Henri-Louis; Varanasi, Kripa K.

DOI: https://hdl.handle.net/1721.1/154924

Thesis

Development of an integrated platform for the production of recombinant biopharmaceuticals

Segarra, Camille · 2013

Full title: Development of an integrated platform for the production of recombinant biopharmaceuticals

Authors: Segarra, Camille

DOI: https://etheses.whiterose.ac.uk/id/eprint/4147/1/Segarra_Thesis_PostCorrections.pdf

Thesis

Purification and biodistribution of extracellular vesicles

Joel Nordin (18664774) · 2017

Full title: Purification and biodistribution of extracellular vesicles

Authors: Joel Nordin (18664774)

DOI: oai:figshare.com:article/26912188

Thesis

Primary Recovery of Biologically Active Compounds Using Macroporous Monolithic Hydrogels

Hanora, Amro · 2005

Full title: Primary Recovery of Biologically Active Compounds Using Macroporous Monolithic Hydrogels

Authors: Hanora, Amro

DOI: https://lup.lub.lu.se/record/545390

Thesis

Downstream purification and analysis of the recombinant human myelin basic protein produced in the milk of transgenic cows : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Chemistry, Massey University (Palmerston North) New Zealand.

Al-Ghobashy, Medhat Ahmed Abdel-Hamid · 2010

Authors: Al-Ghobashy, Medhat Ahmed Abdel-Hamid

DOI: http://hdl.handle.net/10179/1186

Thesis

Partitioning behaviours and selective recovery of therapeutic protein in aqueous two-phase system

Chow, Yin Hui · 2016

Full title: Partitioning behaviours and selective recovery of therapeutic protein in aqueous two-phase system

Authors: Chow, Yin Hui

DOI: http://psasir.upm.edu.my/id/eprint/70219/1/FK%202016%2021%20T%20IR.pdf

Thesis

An improved process for the production of highly purified recombinant thaumatin tagged-variants

Healey, RD; Lebhar, H; https://orcid.org/0000-0002-9023-2467 et al. · 2017

Full title: An improved process for the production of highly purified recombinant thaumatin tagged-variants

Authors: Healey, RD; Lebhar, H ; https://orcid.org/0000-0002-9023-2467; Hornung, S; Thordarson, P ; https://orcid.org/0000-0002-1200-8814; Marquis, CP ; https://orcid.org/0000-0003-1656-7215

DOI: http://hdl.handle.net/1959.4/unsworks_73890

Thesis

Delipidation Treatments for Large-Scale Protein Purification Processing

Gardner, Tara Conti · 2014

Full title: Delipidation Treatments for Large-Scale Protein Purification Processing

Authors: Gardner, Tara Conti

DOI: http://hdl.handle.net/10919/36512

Thesis

Purification of recombinant biopharmaceuticals by preparative electrophoresis

Catzel, Dallia · 2006

Full title: Purification of recombinant biopharmaceuticals by preparative electrophoresis

Authors: Catzel, Dallia

DOI: http://hdl.handle.net/1959.4/68595

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